ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells CHUK PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors SUMO2 RARA PGR PPARG PPARA PIAS4 HDAC4 PIAS3 THRB UBE2I VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) RAD1 ATM RAD9B ATR RAD9A UBA52 UBB UBC RPS27A SEM1 MUS81 MRE11 BRCA1 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE POLH GEN1 RFC5 RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RTEL1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 XRCC2 XRCC3 RPA1 RPA2 PALB2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells HGS CTNNB1 EPS15 CBLL1 MET STAM2 SH3GL2 SH3GL1 UBA52 UBB SH3GL3 SH3KBP1 SRC UBC CTNND1 STAM RPS27A CBL CDH1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK RALA SHC2 RALB SHC3 SHC1 YWHAB CRKL NRAS RAP1A MAPK1 HRAS RALGDS MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling PPARA ATF2 CRTC2 SLC46A1 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 LY96 HBB BACH1 NPAS2 HELZ2 RAI1 XPO1 PGRMC2 TGS1 NRIP1 HMOX1 EP300 TBL1X APOB CLEC1B MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 APOA1 HBA2 NR1D1 SIRT1 NCOR1 TBL1XR1 RORA CARM1 MAFK TLR4 BMAL1 CLOCK NFE2L2 RXRA DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) CHUK NFATC3 PRKCB NFATC2 FBXW11 NFATC1 PSMA5 FKBP1A PSMA6 CALM1 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB NRAS HRAS PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PPP3CA PSMD3 PPP3CB PSMD1 IKBKG PPIA BTRC RASGRP1 MAP3K7 RASGRP3 SKP1 PPP3R1 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models CAST YWHAE APP JUN FASLG SOD2 CDC25C FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC44A2 SLC44A5 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer NOTCH1 RBX1 CUL1 SKP1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) GLP1R UCN VIPR1 VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP ADGRE2 SHH GNGT2 ADGRE5 UCN3 UCN2 ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP ADCYAP1 SMO CRH IAPP ADCYAP1R1 RAMP2 CALCA RAMP3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 PTHLH CRHR1 GHRHR WNT6 GNG10 GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 WNT2 CD55 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 FZD4 WNT3A PTCH1 FZD7 GCGR WNT7B FZD6 PTCH2 FZD9 SCTR FZD8 WNT7A GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH GNB1 GNAS GNB4 GNB3 GNB5 VIP RAMP1 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs SPRED3 SPRED2 SPRED1 SYNGAP1 PSMA5 PSMA6 RASA3 PSMA3 RASA4 PSMA4 RASA1 PSMA1 RASA2 PSMA2 CUL3 UBA52 RASAL1 RASAL2 PSMD12 RASAL3 PSMD11 DAB2IP PSMD14 NF1 PSMD13 KBTBD7 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NRAS HRAS PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis GAD2 GAD1 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG5 IDS CSPG4 GUSB ARSB IDUA HEXB NCAN HEXA BGN DCN GLB1L3 GLB1L2 BCAN VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants FLT3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion PLK1 CCNB1 CDK1 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 XPO1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 FIRRM DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells PRL DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) MSH6 MSH2 MSH3 PMS2 MLH1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors OXTR AVPR1B AVPR2 OXT AVP AVPR1A SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS PTDSS2 PTDSS1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins CASP3 CTNNB1 DSG1 PKP1 DSG2 DSG3 TJP2 DSP TJP1 OCLN CDH1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin FDX1 FDXR FDX2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family HLA-DRB3 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 ASH2L CD3G MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 TEAD3 H3-3B HLA-DPA1 TEAD4 H3C8 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 YAP1 DERL3 DERL1 DERL2 TRBV12-3 CTNNB1 H3C15 PAK1 TRBV7-9 OS9 SPOP RICTOR PAK3 PAK2 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 TRAV8-4 HLA-DPB1 FOSB CD86 TUSC3 CD80 TRAC H2AB1 GRAP2 NEK2 MAP3K8 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 BTLA THEM4 TNFRSF14 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 MAP3K14 PRR5 GSK3B PIK3CD DPY30 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EP300 EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA CREBBP DAD1 LCK IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN CSK NFE2L2 RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 TNRC6A TNRC6B JUN RBX1 CUL3 CCND1 CDK4 PPP2R1B PPP2R1A PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 TRBC1 AKT1 ICOSLG PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B TRIB3 ATF3 RPN2 EPAS1 MAPKAP1 RPN1 PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 PIK3R5 TRAV29DV5 HLA-DQA2 LYN WWTR1 HLA-DRB5 YES1 H4C9 HLA-DRB4 JUND ERLIN1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 CD28 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane GJA1 GJB2 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding STAT3 CCNE2 CCNE1 HDAC3 GNGT1 GBA1 GNGT2 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B TUBA4A FBXW2 XRN2 GAPDHS FKBP9 TP53 ARL2 TBCD TBCC TBCB TBCA CCT6A GNAQ GNG10 TBCE PDCL GNG3 FBXL3 FBXL5 GNG2 TUBA8 WRAP53 GNG5 TUBA1C GNG4 TUBA1B GNG7 TUBA1A GNG8 KIF13A CCT3 CCT2 CSNK2A1 VBP1 CSNK2A2 SPHK1 TUBB2B CSNK2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 GNA15 TUBA3D TUBA3C GNA11 CCT8 GNG12 CCT7 GNG11 CCT5 GNG13 CCT4 NOP56 GNB2 ARFGEF2 TUBB4B GNB1 TUBB4A RGS11 GNB4 GNB3 GNB5 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins POM121C NUP42 NUP62 NUP43 TPR BANF1 NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 SLC25A5 SLC25A4 SLC25A6 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MAD2L1 BUB1B ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 CCNB1 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions GJA10 GJC1 PANX1 GJD2 PANX2 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection POM121C NUP42 NUP62 TPR NUP88 RAE1 KPNA1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 RPL35 KPNA4 RPL38 KPNA5 NUP107 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 NUP160 KPNB1 RPS4Y2 RPS4Y1 RPL39L NUP85 CPSF4 RPL41 TGFB1 MLKL EIF2AK2 ISG15 RPL3L XPO1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 SEC13 RPS24 RPS23 NUP133 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 NUP43 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RANBP2 RPL23A UBA52 RPL22L1 FAU RAN RPL26L1 HSPA1A RPS27A NUP37 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 NUP205 POM121 NUP188 AAAS DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling BLK ELF1 ELF2 CBFB PAX5 RUNX1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 NUP37 NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 THOC6 SRRM1 DDX39A NUP107 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 NUP160 CHTOP ALYREF UPF3B MAGOHB NXF2B NUP85 RNPS1 SEC13 NUP133 NUP205 POM121 NUP188 AAAS FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate ZNF521 WNT3A SOX2 ZEB2 FGF8 SOX1 GBX2 OTX2 TBX6 POU3F1 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX PRKRA DICER1 TARBP2 TSN AGO3 AGO4 AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 MCOLN3 TRPC5 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN LAMA5 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 AP1G1 PACS1 AP1S2 AP1B1 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD9 PSMB2 PSMD4 PSMB3 PSMD5 PAAF1 PSMB1 PSME3 PSME4 ADRM1 PSME1 PSME2 SEM1 PSMD10 PSMB11 PSMC5 POMP PSMC6 PSMB10 PSMC3 PSMA8 PSMC4 PSMF1 PSMC1 PSMB8 PSMC2 PSMB9 PSMG3 PSMG4 PSMG1 PSMG2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation UBE2D1 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 PDPK1 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 PSMD8 V1-3 IKBKB IGKV3D-20 PSMD6 V5-6 PSMD7 TRAF6 PSMD2 IGHE PSMD3 IGLV3-19 PSMD1 IGKV2-30 IKBKG IGHV2-70 BTRC RASGRP1 IGHV2-5 MAP3K7 IGLV3-1 SKP1 IGHV3-48 CHUK IGLV3-25 IGLV3-27 FBXW11 IGKC PSMA5 IGLV3-21 PSMA6 IGKV1-39 PSMA3 IGKV1-33 PSMA4 V4-6 PSMA1 IGHV3-53 PSMA2 V4-2 UBA52 IGLC7 CARD11 V4-1 PSMD12 IGKV5-2 PSMD11 IGKV1-5 PSMD14 IGLC6 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LYN TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity YWHAE CSF1 MC4R HINT1 EDNRB QARS1 ZIC1 RPS6KA1 TNFSF11 SOX9 YWHAH FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB CDH1 PAX3 MITF POU3F2 CTNNB1 YWHAZ SOX10 DARS1 MC3R LARS1 KIT TFEC EEF1E1 HDAC1 KARS1 ALX3 YWHAB IARS1 MARK3 TBX3 POMC MAPK1 UBE2I AIMP1 AIMP2 MC1R MAPK3 EPRS1 ID1 MC5R SNAI2 SUMO1 GSK3B SOX2 AKT3 XPO1 YWHAG EP300 WNT3A CREBBP SIRT1 LEF1 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 CAV1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME VAV3 ABCC4 GSTM1 TPMT ABCC5 NME2 GMPS NME1 RAC1 VAV2 IMPDH1 GUK1 GSTA2 IMPDH2 GSTA1 HPRT1 SLC28A2 SLC29A1 NUDT15 VAV1 XDH SLC29A2 SLC28A3 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CUL3 CCT6A HSP90AB1 ROCK1 ROCK2 CCT2 GPS1 TWF1 MSI2 RHOBTB1 ACTG1 RHOBTB2 TRA2B MYO6 STK38 RBBP6 RNF20 SPEN CPSF7 TMOD3 ACTN1 TXNL1 COPS4 COPS2 HSP90AA1 CDC37 PHIP PDE5A CCT7 VIM HNRNPC RBMX DBN1 SRRM1 DDX39B UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM6 MCM2 GINS1 GINS2 CDC45 MCM8 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing FURIN PCSK6 PCSK5 NGF LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1 TGFBR2 TGFB1 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling FKBP1A TNRC6A PRKAG1 TNRC6B PRKAG2 CAB39L RPTOR STK11 EEF2K PRKAG3 STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD AKT1S1 CAB39 EIF4EBP1 PGK1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 EIF4G1 LAMTOR5 YWHAB RPS6 AKT2 AKT3 AKT1 PRKAB2 MLST8 PRKAB1 PRKAA1 PRKAA2 MOV10 AGO3 AGO4 AGO1 MTOR AGO2 TNRC6C DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy ACY1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 SV2C SYT1 SV2B SV2A VAMP1 VAMP2 STX1A APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated APC TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters SLC34A1 SLC34A3 SLC34A2 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CHUK IKBKB IKBKG REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) RAN FASN TM7SF2 GGPS1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK INSIG2 SAR1B RXRA INSIG1 ACACB ACACA PMVK SCAP SC5D PPARA FDFT1 FDPS MBTPS1 SEC24B SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SEC24D KPNB1 SEC24C SMARCD3 MBTPS2 CHD9 HELZ2 TGS1 TBL1X NCOA1 MED1 NCOA2 CREBBP NCOA6 TBL1XR1 CARM1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor CALM1 DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell HGS EPS15 MET STAM2 SH3GL2 SH3GL1 UBA52 UBB SH3GL3 SH3KBP1 UBC STAM RPS27A CBL MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBB UBA52 UBC RPS27A REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis GSDMD TNFRSF10B GZMB TNFRSF10A ITCH CHMP2B CHMP2A FAS CYCS FASLG UBA52 BAX STUB1 OGT GSDME UBB UBC RPS27A CASP3 TP53 MLKL TRADD HMGB1 UBE2L3 CASP8 CASP5 CASP4 FLOT1 TNFSF10 CASP1 FLOT2 TP63 PDCD6IP RIPK3 IL18 TRAF2 IL1A IRF1 IL1B IRF2 HSP90AA1 CDC37 PELI1 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 FADD BAK1 ELANE DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway VLDLR FYN SH3KBP1 RELN DAB1 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation ATP5MC2 ATP5MC3 MICOS13 MICOS10 ATP5MC1 MT-ATP6 APOO ATP5F1A CHCHD3 SAMM50 ATP5F1B CHCHD6 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME DMAC2L HSPA9 ATP5PF ATP5PD MTX1 APOOL MTX2 ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D MT-ATP8 ATP5F1E TMEM11 ATP5PO RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex UBA52 POLE RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 RPS27A RBX1 PCNA POLD3 POLD4 POLD1 POLD2 WDR48 USP1 UBE2B CUL4A RPA1 DDB1 RPA2 DTL RAD18 POLE4 CUL4B RPA3 POLE2 POLE3 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis CALM1 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 RYR3 SLC8A2 SLN NOS1 CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 TRDN ASPH STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ATP1A3 ITPR2 ATP1A2 ITPR3 ATP1A1 SRI PLN TNNI3 CAMK2G KCNJ11 DMPK ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 FXYD4 FXYD3 FXYD2 FXYD1 FKBP1B FXYD7 FXYD6 TRPC1 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC15 RB1 ANAPC16 ANAPC7 UBE2C UBE2E1 FZR1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S SKP2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence CBX6 PHC2 ATM ACD EZH2 PHC1 H2AX CBX4 ANAPC15 CBX2 ANAPC16 HMGA2 ANAPC7 H1-1 UBE2C PHC3 H1-0 UBE2E1 H1-3 UBE2D1 H1-2 ANAPC10 HMGA1 H1-5 ANAPC11 H1-4 IL6 CDC23 MDM2 UBE2S MDM4 CDC26 CXCL8 CDC27 BMI1 H3-3B CDC16 CABIN1 VENTX ANAPC4 KDM6B H3C8 ANAPC5 RING1 FOS ANAPC1 MINK1 ANAPC2 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP CEBPB RNF2 HIRA MAPK9 MAPK8 H3C15 MAPK7 UBN1 MAP4K4 RB1 CDKN2D CDKN1A CDKN2B CDKN1B CDKN2C CDKN2A FZR1 IFNB1 SUZ12 MAPK10 H2BC9 H3-4 E2F1 H2BC8 E2F2 H2BC5 E2F3 H2BC3 MAPK1 STAT3 CDK6 H2BC1 TFDP1 MAPK3 CCNE2 TFDP2 CDK4 CCNE1 CDK2 H2AB1 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 MAPKAPK3 MAPKAPK2 SP1 H2BC26 H2BC21 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 IL1A H2BC11 RBBP4 RBBP7 H2AZ2 TNRC6C TNRC6A TNRC6B JUN UBA52 LMNB1 RELA RPS6KA1 UBB UBC RPS27A NFKB1 ID1 MRE11 KAT5 TP53 NBN H2AC19 H2AC14 H2BC12L EHMT2 EHMT1 ETS1 ETS2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 MAP2K4 H4C9 TINF2 ERF MAPKAPK5 TNIK ASF1A MOV10 TXN AGO3 RAD50 EP400 AGO4 IGFBP7 H2AC20 MAP2K7 AGO1 MAP2K6 CBX8 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1C RB1 CDKN1A CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) SOS1 PIK3R1 PIK3CA NTRK2 RAC1 DOCK3 BDNF NRAS GAB1 FRS3 GRIN2B HRAS NTF4 CDK5 TIAM1 NTF3 PLCG1 FRS2 CDK5R1 SRC PTPN11 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes SP1 NOTCH1 EP300 MAFK EGF BCL2 PDGFA NFE2L2 AREG CREBBP BCL2L1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 EEF1B2 RPL37 RPS11 EEF1G EEF1A1 EEF1D RPL39 EEF1A2 RPS10 EEF1A1P5 RPS13 EEF2 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) AKT2 AKT3 AKT1 TSC2 TSC1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer NOTCH1 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 ADAM17 NEURL1 MIB2 UBB UBC RPS27A CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling THEM4 MAP3K14 PRR5 AKT2 PIK3CD AKT3 PIK3CB AKT1 PIK3CG MLST8 TRIB3 PDPK1 MAPKAP1 RICTOR PIK3R3 PIK3R2 PIK3R1 PIK3CA PIK3R6 LCK PIK3R5 CD86 FYN CD80 MAP3K8 MTOR CD28 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 NUP37 NUP107 GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 NUP160 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE NUP85 GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 TGS1 SNUPN SEC13 NUP133 NUP205 POM121 NUP188 AAAS BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives ALOX5 PTGS2 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 ABCC8 ABCC9 KCNJ11 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 C3 C4A C5 C4B_2 CFB C2 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion PNLIPRP3 GUCY2C PNLIPRP1 PNLIPRP2 CHIA MGAM AMY2A AMY2B AMY1A TREH AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF CLPS SI PIR ALPI LCT PNLIP RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 ZNF385A PSMD12 PSMD11 COP1 PSMD14 PCBP4 PSMD13 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN1B CDKN2A CCNE2 CCNE1 CDK2 TP53 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity SKP2 RBX1 MAFK UBB UBA52 BACH1 UBC RPS27A FBXL17 CUL1 SKP1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC1A5 SLC7A11 SLC1A6 SLC6A20 SLC7A10 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC36A4 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC6A6 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein MGAT1 MGAT2 GOLGA7 ST3GAL1 TMEM258 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MAGT1 MOGS ZDHHC11 MGAT4C ZDHHC9 MGAT4A OST4 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 OSTC STT3A STT3B RPN2 DDOST RPN1 DAD1 ST6GALNAC2 PRKCSH ZDHHC20 CANX ZDHHC5 TUSC3 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission CALM1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B PPM1E PPM1F GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 CAMK4 NEFL CAMK1 CAMK2G CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response RHBDF2 MYH9 FURIN ADAM17 MAPK14 IL10 IL6 CD163 PLK2 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site CALR CANX ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway TIFA TAB3 TAB2 ALPK1 TAB1 UBB TRAF6 UBA52 UBC RPS27A MAP3K7 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MAD2L1 BUB1B GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway EZH2 H2AX PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 H3-3B TEAD4 H3C8 FOS H2AJ YAP1 H3C15 RICTOR SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 PRR5 GSK3B DPY30 H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PRKAA1 PRKAA2 LEF1 RBBP4 RBBP5 RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C TNRC6A TNRC6B CCNK CCNT2 ELL CCNT1 TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP CTDP1 TAF9 SUPT4H1 TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TP53 TGFB1 PARP1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 SOX2 ZNF521 TRPC3 PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYA NFYB NFYC GPAM SP1 CASP1 TP63 TNFRSF10B TNFRSF10A ITCH FAS CYCS BAX STUB1 PRKACA CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM2 MDM4 BMI1 VENTX RING1 CCNA2 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PRMT5 PHF20 CHEK2 ZNF385A PCBP4 GRIN2A CAMK4 PLK2 MDC1 SPI1 MT-CO1 RBPJ NOC2L ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 SCO2 ZNF705EP DDIT3 DDIT4 TXNIP MT-CO2 MT-CO3 MYL9 ZNF28 ZNF274 ZNF273 MEAF6 ZNF20 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 ZNF26 SFN ZNF268 PPARGC1B ZNF267 PRELID3A ZNF266 ZNF264 ZNF263 ABCA6 NR2F1 ZNF34 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 BBC3 MED12 MED14 MED13 HEY1 CASP10 MED10 ZNF41 HEY2 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 CNOT6L ACTL6B ZNF480 ACTL6A MED27 MED26 SIRT3 DDB2 MED23 MED25 MED24 MMP13 MED20 ZNF479 ZNF235 ZNF234 ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT EGFR BGLAP PLAGL1 SPP1 ZNF227 ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 USP9X ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 UBE2D3 PSMD8 RORC RORB PSMD6 YY1 PSMD7 SESN3 PSMD2 ZNF208 PSMD3 SESN2 PSMD1 ZNF205 ZNF689 KMT5A ZNF688 ZNF446 SKP1 ZNF445 PITX2 PRKCB ZNF202 PSMA5 ZNF443 PSMA6 ZNF200 PSMA3 ZNF684 PSMA4 ZNF442 PSMA1 ZNF441 PSMA2 BNIP3L ZNF682 UBA52 ZNF440 ZNF681 PSMD12 ZNF680 PSMD11 ZFP69B PSMD14 FOXP3 PSMD13 NPAS4 CUL1 MAF PSMA7 ZNF439 ZNF679 RELA ZNF678 PSMB6 ZNF436 PSMB7 ZNF677 PSMB4 ZNF676 PSMB5 ZNF433 ZNF675 UBB PSMB2 ZNF432 PSMB3 PVALB ZNF431 UBC PSMB1 ZNF430 RPS27A GRIA2 KMT2D ADRM1 ZNF671 NFKB1 ZNF670 SEM1 CPAP PSMC5 MAX PSMC6 DLX5 PSMC3 DLX6 PSMC4 KMT2B PSMC1 FOXO6 PSMC2 FOXO4 FOXO1 ZNF840P ATXN3 SOCS3 MED30 MOBP ZKSCAN7 HDAC4 ZNF429 MED31 THRB ZKSCAN8 UBE2I ZKSCAN3 VDR SMYD2 NR1H2 RORA ZNF669 ZNF668 NR3C1 ZNF426 NR2C1 ZNF667 ESR1 ZKSCAN5 ZNF425 ZKSCAN4 NR5A1 ZNF665 NR4A2 AR ZNF664 ZKSCAN1 RXRA SOCS4 SUMO1 BCL2L14 ZNF662 ZNF420 RARA ZNF660 PGR PPARG BRPF1 PPARA BRPF3 TNFRSF10C FBXO32 MRE11 G6PC1 BRCA1 TNFRSF10D RGCC ZNF419 KAT5 ZNF418 EXO1 ZNF417 ZNF658 ZNF416 CHEK1 ZNF415 NBN PIN1 TOPBP1 ZNF655 SP7 PPP1R13B COX4I1 COX4I2 RFC5 PTEN RFC3 RMI2 ITGAL PPP1R13L RFC4 ZNF649 DGCR8 YAF2 RFC2 RMI1 NKX3-2 ZNF641 TOP3A TRIM63 HUS1 APAF1 ITGA4 TNFRSF18 RAD51D ARNT RABGGTB DNA2 RABGGTA RHNO1 BLM RRM2B HAND2 ZNF875 PCNA ITGA5 SRF PPM1D WRN ZNF627 ZNF626 BRIP1 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 RBBP8 ATRIP E2F5 ZNF620 BARD1 E2F6 E2F7 E2F8 RPA1 ZNF860 RPA2 PTPN1 MGA TBX5 RAD50 PINK1 RAD51 ZNF619 RPA3 SST IL2RA ZNF616 RAD17 SYT10 RAD1 ZNF615 ATM ZNF614 RAD9B ZNF613 ATR ZNF611 RAD9A PTPN4 ANAPC15 ZNF610 ANAPC16 ANAPC7 TRIM33 SMARCB1 UBE2C CCNC UBE2E1 UXT UBE2D1 LGALS3 ZNF729 ANAPC10 TRIM28 ANAPC11 ZNF727 CCNB1 CDC23 ZNF726 ZNF724 UBE2S CDC26 EPC1 CDC27 CCN2 ZNF721 CDC16 SMARCC1 CDK1 ANAPC4 SMARCC2 ANAPC5 ZFP1 ANAPC1 ZFP2 ANAPC2 ZNF718 ZNF717 ZNF716 SRC ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 ZNF324B CTNNB1 L3MBTL2 FOXG1 MET TGFA ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 YWHAB APOE PCK1 CRADD IQSEC3 MAPK1 SMARCA2 SMARCA4 SNW1 MAPK3 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C MAPK14 CTSL CTSK HNF4A COX8A MAPK11 SREBF1 COX8C PBRM1 SATB2 COX5B COX5A RXRB ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 COX6C GCK ATF2 VEGFA TTC5 CCNG2 CCNG1 HDAC3 MAMLD1 ZFP28 SMARCD3 PRDM7 PRDM1 COX6A1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 XPO1 COX6B2 GEM COX6B1 ZNF92 EP300 GPRIN1 NDRG1 TBL1X HIGD1C IRAK1 TFAP2A PPARGC1A TFAP2B ZFHX3 TFAP2C MED1 TFAP2D CREBBP AUTS2 MEF2C TFAP2E CNOT10 IL2 IL3 BMP2 NR1D1 SIRT1 CNOT11 TCF3 NCOR1 DYRK2 TBL1XR1 LDB1 CARM1 CHD4 CHD3 TRIAP1 BMAL1 PIDD1 YWHAQ MYBL2 TGIF1 ZNF75CP RBM14 TGIF2 CAT TMEM219 RETN NFATC2 AURKA INS CALM1 MTA2 RRM2 YWHAE ZNF804B REST JUN KRAS FASLG ZNF175 SOD2 MAML2 CDC25C MAML1 FOXO3 SERPINE1 GLS NAMPT ZSCAN32 MYB PIP4K2A PRDX2 BCL2L11 PIP4K2B JUNB CDK5 ZNF169 RNF111 GAMT PRDX1 ZNF705G ZNF705D ZNF160 CDK5R1 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 NOTCH1 RBX1 ZNF155 ZNF154 ZNF394 NEDD4L NKX2-5 NR2C2AP NFE2 IHH PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 SETD1B SETD1A CDC7 NR1D2 ZNF37A ZNF702P ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET GPI BTG2 RARG BTG1 SETD9 CRH CHM GLI3 GLI2 ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 RSPO3 ZNF124 ZIK1 BRD2 BRD1 TCF12 NCOR2 KAT2B KAT2A TAL1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 GPS2 ZNF589 ZNF347 BRD7 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 WWOX ZNF582 PCGF6 TIGAR PCGF5 PCGF2 WWP1 HIPK1 POU4F1 POU4F2 ZNF33B HIPK2 ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 ITGA2B YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 MEN1 ZNF563 IGFBP1 ZNF562 GAD1 ZNF320 GAD2 ZNF561 USP7 ZNF560 IGFBP3 USP2 NRBP1 KAT6A ZNF559 ZNF317 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 NOTCH2 ZNF793 ZNF551 CSF1R RB1 ZNF792 CDKN1A NOTCH3 CDKN1B ZNF550 CCND3 ZNF791 ZNF790 FZR1 CCND2 NOTCH4 CCND1 ZNF767P E2F1 ZNF549 ZNF548 ABL1 ZNF547 SKP2 DAXX ZNF546 ZNF304 ZNF544 CDK6 ZNF786 TFDP1 CCNE2 ZNF302 ZNF785 TFDP2 ZNF543 CDK4 CCNE1 SKIL ZNF300 CDK2 PLXNA4 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC PPP2R1B CNOT4 PPP2R1A CDK8 ZFP69 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 ZNF774 CNOT9 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 SIN3A ZNF528 ZNF764 LBR ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 HDAC2 SMARCD2 PPP2R5C RNF34 GLS2 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 BIRC5 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 AURKB KCNIP3 KLF4 PML ZNF738 PPP2CA ZNF737 PPP2CB ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 TP53AIP1 ZNF607 ZNF606 ZNF605 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 CITED1 CITED2 CITED4 PRMT6 KRABD5 KRABD4 PRMT1 MSH2 KRABD3 GP1BA PMS2 SGK1 ZNF2 MLH1 ZNF3 NPY ARNT2 ZNF354A ZNF354C ZNF354B STEAP3 LMO1 LMO2 TJP1 KCTD1 OCLN ATP1B4 LIFR KCTD6 FANCD2 COXFA4 NOP2 COX7A2 CCNH COX7A1 PMAIP1 POLR2A SMAD2 POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E CBX5 POLR2F SMURF2 POLR2G CBX3 POLR2H SMURF1 POLR2I SMAD6 POLR2J ESR2 POLR2K SMAD7 POLR2L NR4A1 TP53I3 GTF2H1 NR4A3 GTF2H2 JMY SUPT5H KDM5B GTF2H3 THRA GTF2F1 CGB8 GTF2F2 SLC2A3 GTF2H4 NR2E1 GTF2H5 YBX1 CDK7 CASP6 ERCC3 CASP2 ERCC2 AXIN1 MNAT1 OPRM1 ARID1A ARID1B RBL2 H2AC19 RBL1 H2AC14 IFNG H2BC12L ZNF197 AKT2 ZNF195 MYC NR2C2 AKT3 THBS1 HSPD1 AKT1 ERBB2 HES1 PRKAB2 ZNF189 CSNK2A1 ZNF286A CSNK2A2 ZNF184 PRKAB1 ZNF180 CSNK2B OPRK1 ARID3A DEK MAPKAP1 WWTR1 YES1 H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins ALOX5 HPGD LTA4H XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics CYP2C19 CYP3A4 ARNT CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 ARNT2 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP2E1 CYP2F1 CYP2J2 CYP3A43 AHR IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport UBA52 CUL1 STEAP4 TFRC HFE SLC40A1 TCIRG1 HEPH UBB SLC22A17 FTH1 ATP6V1E1 UBC ATP6V1E2 ATP6V0B RPS27A ATP6V1G1 ATP6V0E1 ATP6V1G2 GLRX3 ATP6AP1 SLC11A2 TFR2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 FTL ABCG2 STEAP3 ATP6V1B1 ATP6V1A IREB2 NEDD8 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 CYBRD1 CP TF LCN2 ACO1 SLC46A1 FBXL5 HMOX1 MCOLN1 SKP1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 CCNE2 CCNE1 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN ZBP1 TBK1 IRF3 NLRP4 DTX4 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPO CA9 ARNT EP300 HIGD1A EPAS1 CREBBP CITED2 HIF1A VEGFA BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA DBT BCKDHB DLD COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization COL9A2 COL6A5 COL1A1 COL1A2 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL3A1 COL2A1 COL4A2 COL5A1 COL4A1 COL7A1 COL6A2 COL5A3 COL4A4 COL5A2 COL6A1 COL4A3 COL4A6 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism HDLBP FURIN PCSK9 PCSK6 AP2A1 PCSK5 LIPA AP2A2 LIPC CREB3L3 PRKACG UBA52 LIPG LDLRAP1 PRKACB AP2M1 MYLIP CUBN VLDLR AMN APOA2 APOA4 LSR APOA5 NPC1 SOAT1 SOAT2 NPC2 UBB ANGPTL8 ANGPTL3 ANGPTL4 UBC LPA CES3 RPS27A ABCG1 CETP MTTP LCAT LPL LMF2 LMF1 AP2S1 APOF A2M LDLR GPIHBP1 FGF21 ABCA1 APOC4 NR1H3 APOE APOBR APOC3 AP2B1 NCEH1 APOC2 NR1H2 APOC1 ALB P4HB ZDHHC8 SAR1B PRKACA MBTPS1 MBTPS2 APOB CLTC CLTA APOA1 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) GUSB NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration ACO1 IDH1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism B3GNT3 PCK1 CTSL GCK SLC9A1 G6PD CALM1 PRKACG PRKACB SLC35B3 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 GPI ENO1 ENO2 HS6ST1 ST3GAL4 ENO3 ENO4 HS6ST2 HS6ST3 ST3GAL1 NDST2 ST3GAL2 NDST1 ST3GAL3 NDST4 NDST3 XYLB GAPDHS GLCE OMD ABCC5 TALDO1 PHKA1 PHKA2 HSPG2 PPP1R3C NHLRC1 HS3ST3A1 SDC4 SDC2 SDC3 SLC35D2 GNS ABO CHST11 CHST12 CHST15 CHST13 ST3GAL6 CHST14 B4GALNT2 PCK2 DERA EXT1 EXT2 B4GAT1 SDC1 PYGB GBE1 STAB2 AKR1B1 PYGM PYGL KHK GYS2 GYS1 HYAL2 B3GALT2 B3GALT1 MANBA CHST6 CHST7 TPI1 GAA PGAM1 PGAM2 AKR1A1 PGM2L1 B3GNT7 NUP205 B3GNT4 POM121 FAM20B CHST1 NUP188 B3GNT2 AAAS ALDOC POM121C ALDOB ALDOA NUP42 TKT NUP62 CHST5 TPR CD44 NUP88 SPAM1 CHST2 RAE1 CHST3 NUP214 PAPSS2 NDC1 RHD NUP210 PAPSS1 EXTL2 NUP155 GPC1 HAS1 NUP153 NUP93 HAS3 GPC3 NUP50 SLC17A5 NUP35 IDUA GPC2 NUP54 HEXB HAS2 NCAN GPC5 HEXA GPC4 BGN EXTL3 GPC6 DCN AGL GLB1L3 PGK1 GLYCTK GLB1L2 BCAN LYVE1 FMOD VCAN GLB1L AGRN CHPF GLB1 HYAL1 NAGLU HYAL3 CHP1 HYAL4 SLC26A11 GYG2 CSPG5 IDS GYG1 CSGALNACT1 CSPG4 EPM2A GUSB ARSB CSGALNACT2 AKR1E2 KERA PGD SHPK RHCE PFKFB2 PFKFB1 SLC26A2 PFKFB4 CEMIP PFKFB3 SLC26A1 HMMR FUT2 FUT1 FUT4 FUT3 FUT6 FUT5 TKFC FUT7 FUT9 DSEL NUP107 PGK2 GCKR SLC37A1 B3GALT4 PHKB B3GALT6 PPP2R1B B3GALT5 PPP2R1A G6PC2 G6PC3 MAN2B2 UST OGN CRYL1 MAN2B1 HPSE GALK1 B4GALT2 B4GALT3 B4GALT1 ADPGK SLC2A1 HK2 NUP160 SGSH HS2ST1 HK1 HK3 DSE NUP85 PGM2 PGLS MAN2C1 SLC37A4 PGM1 HS3ST3B1 CHPF2 DCXR SORD BPGM HKDC1 ALDH1A1 PXYLP1 LALBA B4GALT6 SEC13 GAPDH B4GALT7 NUP133 FBP1 FBP2 RBKS PPP2R5D B4GALT4 B4GALT5 ST6GALNAC6 PRPS2 PRPS1 GALT RPEL1 RPE PRELP ACAN UGP2 CHSY1 PHKG1 PHKG2 CHSY3 PRPS1L1 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 PPP2CA HS3ST6 PPP2CB HS3ST4 NUP43 HS3ST1 HS3ST2 GALNS RPIA PFKL GALE RANBP2 GNPDA1 UBA52 PC GNPDA2 GALM PFKM PFKP UBB UBC RPS27A NUP37 PRKACA G6PC1 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 SRGAP3 SRGAP2 SRGAP1 CDC42 ROBO1 RAC1 ARHGAP39 SLIT2 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTF3 NTRK2 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TBK1 UBA52 TICAM2 TICAM1 TANK TLR4 LY96 TRAF3 UBB CD14 IKBKE OPTN UBC RPS27A ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation ADH1B ADH1A ALDH1A1 ADH7 ACSS1 ADH5 ADH6 ADH4 ACSS2 ALDH2 ALDH1B1 ADH1C FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants FLT3LG UBB UBA52 FLT3 UBC RPS27A CBL DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 PPARG MTA2 PPARA PPARGC1B MBD3 GATAD2B GATAD2A UCP1 PPARGC1A HNRNPU NCOA1 MTA1 HDAC1 PRDM16 HDAC2 ZNF423 MTA3 ELOVL3 CIDEA EBF2 BMP7 CHD4 RBBP4 CHD3 COX7A1 RBBP7 SMAD1 SMAD4 RXRA SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins NFKBIA UBE2I TOPORS RELA IKBKE EIF2AK2 IKBKG PIAS4 SUMO1 PIAS3 SUMO3 NFKB2 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK HPRT1 AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP ADA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins GSK3A MGAT1 PARP6 PARP4 ST3GAL1 GALNT1 ST3GAL2 PARP16 ST3GAL3 PARP9 ST6GAL1 PARP14 PARP8 MOGS PARP10 UBA52 ST6GALNAC3 ST6GALNAC4 GSK3B UBB UBC RPS27A UBE2I ST6GALNAC2 PRKCSH CANX GANAB SUMO1 ST3GAL4 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway NFATC1 TNRC6A CALM1 TNRC6B CTNNB1 GNGT1 GNGT2 WNT5A GNAT2 TCF7 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 PLCB2 NLK PDE6B CAMK2A GNG10 PDE6A GNG3 PDE6G ITPR1 GNAO1 GNG2 ITPR2 WNT11 GNG5 ITPR3 GNG4 GNG7 GNG8 FZD3 FZD2 FZD5 FZD4 FZD6 LEF1 GNG12 GNG11 GNG13 GNB2 MOV10 GNB1 PPP3CA TCF7L2 AGO3 PPP3CB AGO4 GNB4 TCF7L1 GNB3 AGO1 GNB5 MAP3K7 AGO2 PPP3R1 TNRC6C TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors YEATS4 PITX2 CGA KDM5B CGB8 NPM1 EGFR VEGFA MYC CITED1 HSPD1 CITED2 ERBB2 CITED4 ATAD2 KCTD15 EP300 DEK TGFA TFAP2A CDKN1A TFAP2B KIT WWOX TFAP2C TFAP2D CREBBP TFAP2E APOE KCTD1 UBE2I NOP2 YY1 ESR1 MYBL2 SUMO1 DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS MAOA ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs ALK EML4 FN1 PPM1B HIP1 PRKAR1A CLTC BCL11A NPM1 EIF2AK3 STRN BIRC6 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism PRODH PRODH2 ALDH4A1 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication POM121C NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 NUP107 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 NUP160 RPS4Y2 RPS4Y1 RPL39L NUP85 RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 GRSF1 RPS21 SEC13 RPS24 RPS23 NUP133 RPLP1 RPLP0 RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 NUP43 RPS2 RPL18 RPL17 RPL19 RPL35A RANBP2 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A NUP37 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 NUP205 POM121 NUP188 AAAS ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP2B CHMP2A UBA52 UBB UBC RPS27A STAM HGS STAM2 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C CHMP4C VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A SNF8 CHMP6 UBAP1 CHMP7 VPS25 VPS28 CHMP5 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known CBX6 PHC2 PBRM1 PHC1 CBX4 CBX2 SMARCB1 PHC3 ARID1A BMI1 ARID1B CBFB SMARCD3 SMARCC1 SMARCC2 RUNX1 RING1 ARID2 YAF2 CSNK2A1 RNF2 CSNK2A2 CSNK2B EP300 SMARCD1 AUTS2 SMARCD2 PCGF5 SMARCA2 SMARCA4 HIPK2 RYBP ACTL6B ACTL6A SMARCE1 CBX8 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 TUFM MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints ATM FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 ZNF385A PSMD12 PSMD11 COP1 CDC25A PSMD14 PCBP4 PSMD13 CUL1 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN1B PLK3 CDKN2A CCNE2 CCNE1 CDK2 MAPK14 MAPK11 TP53 CHEK1 CSNK1E CSNK1A1 NEK11 GSK3B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) FKBP1A TGFBR1 TGFBR2 UBA52 ARHGEF18 CGN F11R PRKCZ UBB TGFB1 RHOA PARD6A PARD3 UBC RPS27A SMURF1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis POM121C POLR2I NUP42 POLR2J NUP62 NUP43 POLR2K TPR POLR2L NUP88 RAE1 NUP214 RANBP2 NDC1 GTF2F1 NUP210 GTF2F2 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 POLR2A POLR2B POLR2C NUP205 POLR2D POM121 NUP107 POLR2E NUP188 POLR2F POLR2G AAAS POLR2H CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling RPS6KA5 CD209 EP300 PAK1 PRKACA PAK3 PRKACG PAK2 CREBBP PRKACB NRAS LYN RELA HRAS FYN RAF1 ICAM2 ICAM3 NFKB1 RELB ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 RAB7A EPHA2 VAMP3 ARHGEF26 GARRE1 SHMT2 PLD1 IQGAP2 KALRN ARHGAP39 ARHGAP21 LMAN1 STX5 YKT6 PAK4 NDUFA5 TFRC MCF2 MCAM ERBIN HSPE1 VAV1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 VAPB ESYT1 PAK2 DOCK3 DSG2 CAV1 VAV3 VAV2 LBR PGRMC2 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO PIK3R1 ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 CDC42 MCF2L ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 RHOG MAP3K11 VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism PPP1CC PRKACA PRKACG PRKACB GPAM MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 CAV1 PLIN3 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 MGLL LPIN3 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors YEATS4 EP300 TFAP2A TFAP2B WWOX TFAP2C TFAP2D CITED1 CREBBP CITED2 TFAP2E CITED4 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose GMPPB PMM1 GMPPA PMM2 MPI HK1 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PPP2CA CHUK PPP2R1B PPP2R1A PPP2R2A PIEZO1 ITGAV ANXA2 PTK2 GNAQ RELA CAPNS1 CAPNS2 CAPN2 IKBKE YAP1 NFKB1 NFKBIA ITGB1 ITGB3 ITGA5 ABL1 STAT1 GNA11 IKBKB PTPN1 VCL IKBKG DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 ABCA3 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBA52 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF UBB UBC RPS27A CBL SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors RAC1 SRC PAK1 PAK3 PAK2 SOS1 RHOA CDC42 LDB1 PPP3CB COL4A5 PRKACG PRKACB ELOB ELOC PAK4 NCBP1 NCBP2 RBX1 DAG1 HOXA2 ISL1 PFN1 PFN2 GSPT2 GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH PABPC1 CXCR4 AKAP5 ZSWIM8 PAK6 PAK5 CAP2 MYO9B MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 GPC1 EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 ABL1 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 CLASP1 PSMA4 RPL19 PSMA1 CLASP2 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 PSMD14 ARHGAP39 PSMD13 SLIT2 SRGAP3 PSMA7 SRGAP2 SRGAP1 ROBO1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4A3 CASC3 MAGOH PRKACA RBM8A PRKCA UPF3B MAGOHB RNPS1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SLC35C1 ALG5 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS SLC17A5 AMDHD2 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA NUS1 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 GLB1 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ST6GALNAC2 MVD ST3GAL4 GMPPB PMM1 GMPPA ST3GAL1 PMM2 MPI ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 ST6GALNAC4 HK1 ST3GAL6 ST6GALNAC6 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry FURIN TMPRSS2 SDC1 VCP ACE2 HAVCR1 GPC1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 NRP1 AGRN CTSL ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling TGFA ELK1 CDKN1B EREG SRF PTK2 UHMK1 BTC EPGN FOXO3 CCND1 HBEGF EGFR MAPK1 MAPK3 FOS EGF AKT2 BCL2 AKT3 AREG AKT1 XPO1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival NFKBIA IRAK1 UBA52 NGFR SQSTM1 RELA IKBKB UBB TRAF6 UBC NGF RPS27A NFKB1 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis DDC TH DBH PNMT CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis CSPG5 CSGALNACT1 CSPG4 CSGALNACT2 UST CHST3 CHST7 NCAN BGN DCN CHSY1 CHST11 BCAN CHST12 CHSY3 VCAN CHST15 CHST13 CHPF CHPF2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 CHMP2A APP AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 GNS HGS SH3GL2 ARRB1 CLTC VAMP2 CLTA ARF1 CTSZ AP4E1 CLTB AP4M1 AP1G2 BLOC1S1 CLVS2 AP4S1 CLVS1 TXNDC5 HSPA8 M6PR METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation HEMK2 NNMT MTRR AHCY TPMT GSTO1 MTR MAT1A MAT2B COMT CYP1A2 TRMT112 AS3MT MAT2A INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins CDK9 CCNT1 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling SOS1 THEM4 KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS ABCC2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 ITGB1 LAMA4 LAMA3 ITGAV LAMC2 LAMB1 LAMC1 ITGB4 ITGA3 HSPG2 ITGA2 ITGA1 NID1 NID2 ITGA7 ITGA6 COL18A1 LAMA5 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis H2AX GATA2 MYB H3-3B CBFB H3C8 RUNX1 H2AJ CEBPB H3C15 CDKN1A H2BC9 E2F1 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 TFDP1 TFDP2 CDK4 CDK2 H2AB1 RXRA H2AC8 H2AC6 H2AC7 RARA KMT2A TAL1 H2AC19 H2AC14 H2BC12L MYC H2BC26 H2BC21 EP300 DEK H2BC17 SPI1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 LEF1 H4C9 CSF3R GFI1 IL6R CEBPA CEBPE FLI1 H2AZ2 KLF5 H2AC20 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation UBE2O TPP2 BLMH UBA1 UBE2K UBE2M TRIM71 ANAPC7 RNF14 UBE2C KBTBD13 UFL1 UBE2E1 UBE2Q1 UBE2D1 UBE2Q2 ANAPC10 TRIM69 ANAPC11 UNKL DTX3L CDC23 PJA2 UBE2S PJA1 CDC26 TRAF7 CDC27 UBE2R2 CDC16 THOP1 TRIM50 ANAPC4 MGRN1 ANAPC5 ASB13 ANAPC1 ASB14 ANAPC2 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 VHL TRIM41 UBE2D2 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 MIB2 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 CDC34 ASB3 ASB1 UBE2V1 UBE2N ELOB ELOC MYLIP RNF111 RBX1 NEDD4L FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 FBXL3 FBXL5 CUL2 RBBP6 WWP1 CUL3 KBTBD7 FZR1 SKP2 CDC20 UBE2L3 RNF34 UBE2D3 PSMD8 PSMD6 PSMD7 PSMD2 PRKN PSMD3 PSMD1 LRR1 CCNF BTRC KEAP1 CBLB SKP1 UBE2L6 HERC5 DCAF1 FBXW11 HERC4 PSMA5 HERC3 PSMA6 ITCH RNF115 PSMA3 HERC2 PSMA4 RNF114 PSMA1 HERC1 PSMA2 TRIM21 UBA52 FBXO7 STUB1 HERC6 PSMD12 FBXO9 PSMD11 WSB1 PSMD14 FBXO2 PSMD13 RNF123 CUL1 RNF126 HECW2 PSMA7 RBCK1 CBLL2 TRIM11 PSMB6 ANAPC13 PSMB7 UBE2J2 PSMB4 UBE2J1 PSMB5 RNF213 UBB RNF217 PSMB2 ATG7 PSMB3 HACE1 UBC SIAH2 PSMB1 SIAH1 RPS27A LNPEP ADRM1 MEX3C UBAC1 SEM1 FBXL8 FBXL4 PSMC5 DZIP3 PSMC6 FBXL7 PSMC3 RNF220 PSMC4 DET1 PSMC1 LRSAM1 PSMC2 SH3RF1 TRIM9 TRIM4 ARIH2 SOCS3 LRRC41 RNF144B GAN RNF138 RNF130 HUWE1 KCTD6 KLHL2 UBE2G1 KLHL3 UBE2B UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 SMURF2 KBTBD8 SPSB4 SMURF1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A FBXO32 UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 TRIM63 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 RNF182 UBA3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 XRN2 GAPDHS FKBP9 TP53 CCT6A HDAC3 FBXL3 FBXL5 WRAP53 KIF13A CCT3 CCT2 SPHK1 SKIC2 TCP1 USP11 AP3M1 STAT3 GBA1 CCT8 CCT7 DCAF7 CCT5 CCT6B CCT4 CCNE2 NOP56 ARFGEF2 CCNE1 FBXO4 LONP2 FBXO6 FBXW4 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 FBXL21P PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CRY2 CRY1 PER2 PER1 PER3 FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 MET ITGB1 LAMA4 LAMA3 LAMC2 LAMB1 PTK2 LAMC1 ITGA3 ITGA2 HGF SRC LAMA5 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PATJ PALS1 CRB3 TJP1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 FGFBP1 FGF1 FGFBP2 FGF2 FGF3 FGFBP3 FGF4 FGF6 FGF7 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency GSS SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle CDC42EP1 IL32 GIT2 ARHGAP26 BAIAP2 TAOK3 RAB7A ABI2 EPHA2 NOXA1 VAMP3 ABI1 NOX3 GARRE1 NOX1 FERMT2 ARHGAP39 ARHGAP21 LMAN1 SRGAP2 YKT6 PAK4 TFRC MCF2 MCAM ERBIN SLC1A5 MPP7 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 ESYT1 PAK1 PAK2 DSG2 TIAM1 CAV1 RAPGEF1 JAG1 VAV2 LBR PGRMC2 NCKAP1 NCF1 NCF2 NCF4 SNAP23 ITGB1 BRK1 ABL2 CYFIP1 ARHGAP6 DOCK10 SYDE1 ARHGAP42 PIK3R2 TRIO BAIAP2L1 PIK3R1 RAC3 ARHGAP1 GIT1 SWAP70 ARHGAP5 ARAP2 ARHGAP35 CYBB PREX1 ARAP3 OPHN1 OCRL CYBA STBD1 BCR CDC42 AMIGO2 ARHGDIB NOXO1 EMD ARHGAP17 TMPO ARHGAP15 ABR RACGAP1 SLITRK3 VRK2 NHS LEMD3 SLITRK5 NCKAP1L DEPDC1B WASF1 WASF2 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 SPP1 CBFB ITGAL RUNX3 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death EZH2 H2AX CAST YWHAE APP JUN FASLG SOD2 C1QBP CDC25C DNMT3B FOXO3 GSDME DNMT3A CDC25A CDC25B PRIM2 LMNB1 DNMT1 GOLGA2 PRIM1 PRDX2 POLA1 H3-3B BCL2L11 POLA2 CDK5 CAPNS1 CAPNS2 H3C8 PRDX1 CAPN2 CAPN1 H2AJ CDK5R1 H3C15 CDKN2A SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 TP53 H2AC19 H2AC14 H2BC12L MLKL H2BC26 TRADD H2BC21 CASP8 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 RIPK3 TRAF2 H2BC11 H4C9 RBBP4 RBBP7 H2AZ2 RIPK1 H2AC20 FADD IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption PNLIPRP3 RSC1A1 SLC2A2 SLC5A1 SLC2A5 GUCY2C PNLIPRP1 PNLIPRP2 CHIA MGAM AMY2A AMY2B AMY1A TREH AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF CLPS SI PIR ALPI LCT PNLIP RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling PLCG1 EGF ERBB2 EGFR NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases CAST YWHAE APP JUN FASLG SOD2 CDC25C FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis PPIA THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis CD4 DOCK2 AP2A1 AP2A2 AP1G1 RAC1 AP2M1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 HCK CD8B ELMO1 AP2S1 PAK2 LCK AP2B1 ATP6V1H ARF1 FYN CD28 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis SREBF1 PMVK SC5D FDFT1 FDPS CYP51A1 SQLE DHCR7 LBR IDI2 MSMO1 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 PLPP6 TM7SF2 GGPS1 HMGCS1 LSS SREBF2 MVD IDI1 MVK DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation UPK1A EPCAM TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 RAD1 ATM RAD9B ATR PRKAG1 RAD9A PRKAG2 PRKAG3 CCNB1 MDM2 MDM4 CDK1 FOS CCNA2 CCNA1 L3MBTL1 RICTOR CDKN2A YWHAB CRADD TP73 COX7B COX7C MAPK14 COX8A MAPK11 COX8C COX5B COX5A PERP NPM1 COX6C ATF2 TTC5 PRMT5 CCNG1 PRDM1 COX6A1 PRR5 COX6A2 G6PD COX6B2 MLST8 COX6B1 YWHAG EP300 NDRG1 PDPK1 HIGD1C CREBBP CNOT10 PRKAA1 PRKAA2 CNOT11 DYRK2 CARM1 CHD4 RBBP4 CHD3 TRIAP1 PIDD1 YWHAQ RBBP7 MTOR TNRC6C TMEM219 AURKA TNRC6A MTA2 TNRC6B CCNK CCNT2 YWHAE ELL JUN CCNT1 PHF20 CHEK2 TAF7L ELOA CDC25C ZNF385A ELOB GLS PCBP4 NELFB ELOC NELFCD NELFA PIP4K2A PRDX2 NELFE PIP4K2B SUPT16H CDK5 TBP PRDX1 YWHAH CTDP1 CDK5R1 TAF9 SUPT4H1 TAF1L TAF15 TAF12 TAF13 TAF10 YWHAZ TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 PLK3 TAF4B PRELID1 HDAC1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CDK12 CDK13 GPI BTG2 SETD9 CHM ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 TP53 BRD1 BRD7 PLK2 MDC1 MT-CO1 NOC2L TIGAR HIPK1 POU4F1 POU4F2 HIPK2 SCO2 DDIT4 MT-CO2 MT-CO3 MEAF6 RPTOR SFN STK11 PRELID3A TSC2 TSC1 RRAGA RRAGC USP7 RRAGB RRAGD IGFBP3 USP2 KAT6A SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CDKN1A CDKN1B BBC3 CASP10 E2F1 DAXX TFDP1 CCNE2 CNOT6L TFDP2 CCNE1 CDK2 FANCI DDB2 PPP2R1B FANCC PPP2R1A CNOT4 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 CNOT8 PLAGL1 CNOT9 BID MBD3 GPX2 GATAD2B GATAD2A CASP1 TP63 HDAC2 PPP2R5C RNF34 GLS2 NLRC4 BIRC5 SESN3 RFFL SESN2 TXNRD1 KMT5A AURKB PML PPP2CA PPP2CB TNFRSF10B TNFRSF10A TP53RK FAS BNIP3L CYCS TP53AIP1 UBA52 BAX COX7A2L NUAK1 TP53BP2 BANP GADD45A UBB TPX2 UBC RPS27A PRMT1 MSH2 CPAP SGK1 PMS2 MLH1 STEAP3 FANCD2 COXFA4 SMYD2 COX7A2 CCNH COX7A1 PMAIP1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G BCL2L14 POLR2H POLR2I ZNF420 POLR2J POLR2K BRPF1 POLR2L BRPF3 TP53I3 GTF2H1 TNFRSF10C GTF2H2 MRE11 JMY BRCA1 SUPT5H GTF2H3 TNFRSF10D GTF2F1 RGCC KAT5 GTF2F2 GTF2H4 EXO1 GTF2H5 CDK7 CASP6 CHEK1 CASP2 ERCC3 NBN ERCC2 PIN1 MNAT1 TOPBP1 PPP1R13B RBL2 COX4I1 RBL1 COX4I2 RFC5 PTEN RFC3 AKT2 RMI2 PPP1R13L RFC4 AKT3 AKT1 RFC2 RMI1 PRKAB2 TOP3A CSNK2A1 HUS1 CSNK2A2 APAF1 PRKAB1 CSNK2B RAD51D ARID3A DNA2 RABGGTB RHNO1 RABGGTA BLM RRM2B MAPKAP1 PCNA WRN EHMT2 BRIP1 EHMT1 TP53INP1 E2F4 RBBP8 ATRIP BARD1 E2F7 RPA1 E2F8 RPA2 MAPKAPK5 MOV10 TXN AGO3 RAD50 AGO4 RPA3 AGO1 AGO2 MAP2K6 RAD17 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB APEX1 XRCC1 LIG3 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity MEAF6 RAD1 ATM RAD9B ATR RAD9A PRKAG1 PRKAG2 STK11 PRKAG3 MDM2 MDM4 USP7 USP2 CDK1 KAT6A CCNA2 CCNA1 L3MBTL1 RICTOR CDKN2A DAXX TP73 CDK2 MAPK14 MAPK11 PPP2R1B PPP2R1A TTC5 PRMT5 CCNG1 PRDM1 PRR5 MBD3 MLST8 EP300 GATAD2B PDPK1 GATAD2A TP63 HDAC2 PPP2R5C RNF34 PRKAA1 PRKAA2 DYRK2 CHD4 RBBP4 CHD3 RBBP7 RFFL KMT5A AURKB MTOR PML PPP2CA PPP2CB AURKA MTA2 TP53RK UBA52 PHF20 CHEK2 TAF7L ZNF385A PIP4K2A PIP4K2B SUPT16H CDK5 TBP NUAK1 TP53BP2 BANP UBB TPX2 TAF9 CDK5R1 UBC TAF1L RPS27A TAF15 TAF12 TAF13 TAF10 TAF11 SGK1 SSRP1 TAF8 TAF7 PLK3 TAF4B HDAC1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SMYD2 SETD9 BRPF1 BRPF3 ING5 ING2 MRE11 JMY PIP4P1 BRCA1 KAT5 TP53 EXO1 BRD1 CHEK1 NBN PIN1 TOPBP1 PPP1R13B RFC5 RFC3 AKT2 RMI2 PPP1R13L RFC4 AKT3 AKT1 RFC2 RMI1 PRKAB2 TOP3A CSNK2A1 HUS1 BRD7 CSNK2A2 PRKAB1 CSNK2B DNA2 RHNO1 BLM MAPKAP1 NOC2L WRN EHMT2 BRIP1 EHMT1 TP53INP1 HIPK1 POU4F1 RBBP8 POU4F2 ATRIP BARD1 HIPK2 RPA1 MAPKAPK5 RPA2 RAD50 RPA3 MAP2K6 RAD17 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection CD3G RAC1 IL6 VAV1 MAPK8 IGHV3-23 IGLV IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 ADAM17 IGHV4-59 IGHV1-69 IGLV2-11 NFKB2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 HMOX1 C3 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 CYBA V1-7 V5-1 CDC42 V1-5 NOXO1 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 IGLV3-27 ELMO2 IGKC IGLV3-21 DOCK1 BAIAP2 CALM1 IGKV1-39 ABI2 IGKV1-33 V4-6 NOXA1 ABI1 IGHV3-53 JUN V4-2 PRKACG NOX1 IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK ELMO1 GNGT1 GNGT2 ACTB CYFIP2 WIPF1 WNT5A WIPF2 WIPF3 GNAT3 C3AR1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK MEFV PRKAR2B PLCG2 MYO5A ARPC1B ARPC1A VAV3 WASL CTSG PTK2 SYK GNAI3 ADCY4 WAS ADCY3 VAV2 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 NT5E GNG5 PYCARD GNG4 IGHG3 GNG7 IGHG4 GNG8 IGHG1 HSP90AB1 CYSLTR1 IL10 IGHG2 CYSLTR2 CD163 PLK2 GGT1 DPEP2 RHBDF2 DPEP1 MYH9 MYO9B ACTG1 GNAZ NCKIPSD DVL1 DVL2 DVL3 NLRP3 GGT5 FZD7 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 NCK1 FCGR3A ACTR3 ACTR2 FGR MYH2 GNG12 ADORA2B GNG11 FCGR1A GNG13 WASF3 MYO10 GNB2 P2RX7 P2RX4 TXNIP GNB1 FCGR2A GNAS MYO1C GNB4 SUGT1 GNB3 GNB5 FURIN ABL1 CASP1 IL18 IL1A IL1B GSDMD RELA NFKB1 AHCYL1 PRKACA ITPR1 ITPR2 ITPR3 PRKAR1A LYN YES1 TXN INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity TNKS2 WWP2 RNF146 PSMA5 FRK PSMA6 OTUD3 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEDD4 PTEN AKT2 AKT3 AKT1 CSNK2A1 CSNK2A2 CSNK2B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 PREX2 TRIM27 MKRN1 USP13 TNKS ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells CHRNA9 KCNMB1 KCNMA1 CHRNA10 KCNN2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) MSH6 MSH2 PMS2 MLH1 PCNA LIG1 POLD3 POLD4 EXO1 POLD1 POLD2 RPA1 RPA2 RPA3 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC5 GNE NPL NEU2 NEU3 NEU4 ST6GALNAC3 SLC17A5 ST6GALNAC4 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA SLC35A1 ST8SIA1 ST8SIA2 ST3GAL6 GLB1 ST8SIA3 ST6GALNAC6 ST6GALNAC2 ST6GALNAC1 CMAS NANP NANS ST3GAL4 ST6GAL2 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling STAT3 HDAC3 EP300 CD274 PRDM1 HDAC1 SIN3A IL2RG HDAC2 HIF1A DNMT1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol PLCG2 CALM1 INPPL1 PLD4 INPP5B PLCB3 PLCZ1 PLCB1 INPP5D PLCB2 INPP5J PLCE1 ITPK1 ITPKB ITPKC PLCB4 PTEN SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 OCRL PLCG1 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism PM20D1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT PLK1 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 NEK9 SPC25 NEK6 NEK7 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 EML4 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 HVCN1 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ADAM2 ACR KCNU1 CATSPERB CATSPERD CATSPERG CD9 ZP1 ZP3 ZP2 ZP4 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission PRKAG1 PRKAG2 PRKAG3 RAC1 MDM2 SRC NRAS MAPK1 GRIN2B HRAS MAPK3 GRIP1 RPS6KA6 NSF PRKCG CASK KPNA2 GABRG3 GABRG2 GRIP2 GRIA1 LIN7A LIN7C LIN7B EPB41L1 TSPAN7 GRIA3 CHRNA1 GRIA4 CHRNB2 GRIN3B CHRNB4 GNAL CHRNA3 GRIN3A CHRNB3 NBEA CHRNA2 GABRB3 CHRNA5 GABRB2 CHRNA4 GABRB1 CHRNA7 RASGRF2 CHRNA6 RASGRF1 CHRNA9 KIF17 NRGN CHRND GABRR3 CHRNG DLG1 GABRR2 CHRNE DLG3 GABRR1 DLG4 NPTN GRIK5 HTR3E GRIK3 HTR3C GRIK4 HTR3D GRIK1 HTR3A GRIK2 NRG1 HTR3B NCALD ARHGEF9 PICK1 CAMKK1 CAMKK2 GLRA1 PDPK1 GLRA2 CACNG8 GLRA3 CACNG2 CACNG3 KCNJ2 CACNG4 KCNJ3 GABRA2 GIT1 GABRQ KCNJ4 GABRA1 PRKAA1 GABBR2 PRKAA2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GABRA6 GABRA5 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GLRB APBA1 PRKCB CALM1 AP2A1 PRKACG PRKACB RPS6KA1 GRIA2 GNGT1 GNGT2 GNAT3 ADCY9 PRKAR1B PRKAR2B PRKACA GNAI3 ADCY4 PRKCA PLCB3 ADCY3 PLCB1 PRKX PLCB2 ADCY2 CAMK2B ADCY1 ACTN2 CAMK2D ADCY8 GNG10 GRIN2C CAMK2A ADCY7 PRKAR2A PPM1E ADCY6 GNG3 GNAI1 PPM1F GRIN2D ADCY5 GNG2 GNAI2 GRIN1 GRIN2A GNG5 DLG2 GNG4 LRRC7 GNG7 PRKAR1A GNG8 CAMK4 NEFL CAMK1 PRKAB2 AKAP5 CAMK2G PRKAB1 MYO6 RPS6KA3 RPS6KA2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development NEUROD1 NKX6-1 IAPP NKX2-2 INS PDX1 PAX4 PAX6 HNF1B HNF1A MAFA RFX6 MAML2 INSM1 MAML1 PTF1A FOXA3 NEUROG3 GCK FOXA2 KAT2B KAT2A MAMLD1 SLC2A2 AKT2 AKT3 AKT1 HES1 NOTCH1 EP300 RBPJ FOXO1 CREBBP FGF10 SNW1 HNF4G ONECUT3 ONECUT1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes IRAK1 UBA52 NGFR SQSTM1 PRKCI RIPK2 MYD88 IKBKB UBB TRAF6 UBC NGF RPS27A ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade PDE6B SLC24A1 PDE6A PDE6G RHO SAG CNGA1 GNAT1 CNGB1 GNB1 GNGT1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 FOS ATF1 UBB ECSIT NKIRAS1 NKIRAS2 UBC IKBIP MEF2A RPS27A DUSP4 DUSP3 NFKB1 IRAK4 VRK3 MAPK9 NFKBIA DUSP6 MAPK8 DUSP7 MAPK7 TLR10 TLR5 LRRC14 ELK1 USP14 NLRX1 PELI3 PELI2 NFKBIB NLRC5 MAPK10 NOD1 NOD2 AGER USP18 IRAK2 MAPK1 S100A12 N4BP1 MAP3K1 MAPK3 S100B TNIP2 MAP2K1 SAA1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 TP53 ATF2 NFKB2 HMGB1 RPS6KA5 CASP8 UBE2N TIFA TAB3 ALPK1 TAB2 TAB1 IRAK1 PPP2R5D MEF2C TRAF2 RPS6KA3 PELI1 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SREBF1 NRIP1 EP300 TBL1X PPARA PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 NR1D1 HDAC3 NCOR1 TBL1XR1 SMARCD3 RORA CARM1 RORC CHD9 CPT1A HELZ2 RXRA TGS1 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT KIT DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2AC6 H2AC7 EZH2 H2AX DNMT3B GSDME DNMT3A PRIM2 DNMT1 PRIM1 POLA1 H3-3B POLA2 H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 RBBP4 RBBP7 H2AB1 H2AZ2 H2AC20 H2AC8 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions ITGA2B CALM1 FN1 PAPSS1 BCL2L11 ATG7 SRC YWHAB MARK3 NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 TENT4A KIAA1549 MPRIP BRAF TRIM24 AGTRAP AP3B1 SND1 ESRP1 AKAP9 KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 LMNA AGK QKI CLCN6 FAM131B AGGF1 CAMK2B CAMK2D CAMK2A CAMK2G ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 CSK VCL ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium CEP83 DYNLRB2 DYNLRB1 IFT25 CEP89 CEP57 ARF4 C2CD3 CETN2 PLK1 CEP164 PKD2 PKD1 IFT52 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CNGA2 CDK1 BBS9 CNGA4 BBS7 TNPO1 IFT57 CEP290 NINL IFT56 BBS5 CC2D2A BBS4 RAB8A OFD1 DYNLT5 IQCB1 MKKS EXOC8 DYNLT2 IFT140 EXOC7 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 RP2 BBS12 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 EXOC5 NEK2 IFT46 SFI1 EXOC2 SDCCAG8 EXOC1 IFT70B PPP2R1A IFT70A DCTN2 SSNA1 DCTN3 DYNLT2B ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 CEP152 WDR19 GBF1 CSNK1E KIF17 SCLT1 RAB11A ATAT1 NEDD1 TTC8 ALMS1 TRIP11 CEP162 B9D1 CEP41 CEP43 CLUAP1 YWHAG ARL13B INPP5E PDE6D DYNLL1 HSP90AA1 CKAP5 DYNLL2 HDAC6 MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 YWHAE DYNC1H1 NDE1 RHO B9D2 CNGB1 CPAP SMO AKAP9 PRKAR2B TUBA4A PRKACA DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CCP110 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CEP131 CSNK1D IFT80 CYS1 TUBA1A RPGRIP1L LZTFL1 CCT3 IFT88 CCT2 IFT81 UNC119B ARL6 ARL3 FBF1 MCHR1 TCP1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B CEP70 NPHP1 CEP72 NPHP3 CEP192 NPHP4 KIF3C MARK4 CEP76 RAB11FIP3 CCT8 CEP78 PLK4 CCT5 BBS2 CCT4 BBS1 ODF2 RAB3IP TUBB4B IFT122 TUBB4A BBIP1 IFT20 AHI1 IFT22 MKS1 IFT27 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR2K POLR2L TBP GTF3C1 GTF3C2 GTF3C3 CRCP GTF3C4 GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation CBFB GLI2 IHH HDAC4 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network COG7 COG6 COG5 COG4 COG3 COG2 COG1 NAA35 VAMP3 NAA38 VAMP4 NAPA NAPB TMF1 STX16 RHOBTB3 ARL1 NAPG STX10 TGOLN2 ARFRP1 VPS51 VPS53 VPS52 VTI1A STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B PLIN3 NSF M6PR USP6NL SCOC SYS1 GCC2 GCC1 RABEPK RAB43 GOLGA4 GOLGA1 ARFIP2 NAA30 COG8 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins NUDT16 ADPRM NUDT5 NUDT15 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol ADAT2 TRMT9B QTRT1 GON7 DUS2 CTU2 TP53RK QTRT2 CTU1 TRMT5 TRMT6 TRMT13 TRMT11 TRMT61A TRMT112 QNG1 URM1 WDR4 THADA LAGE3 OSGEP THG1L ALKBH8 TYW1 LCMT2 TRMT44 TRDMT1 PUS3 TRMT10A TYW5 METTL1 NSUN2 EPRS1 TYW3 TYW2 TPRKB ADAT1 TRMT1 CDKAL1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling GP5 VWF GP1BA YWHAZ RAF1 PIK3R1 GP9 GP1BB FLNA MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease DDX6 LSM1 LSM5 LSM4 LSM3 PATL1 EDC3 LSM2 EDC4 LSM7 LSM6 XRN1 DCP1A DCP2 DCP1B CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARF4 PKD2 PKD1 CNGA2 RHO BBS9 CNGA4 BBS7 CNGB1 BBS5 BBS4 RAB8A MKKS EXOC8 EXOC7 SSTR3 BBS10 RP2 BBS12 EXOC4 EXOC3 EXOC6 EXOC5 SMO EXOC2 EXOC1 ASAP1 GBF1 RAB11A ATAT1 TTC8 CYS1 CCT3 LZTFL1 CCT2 UNC119B ARL6 ARL3 ARL13B TCP1 MCHR1 INPP5E PDE6D NPHP3 HDAC6 CCT8 RAB11FIP3 CCT5 CCT4 BBS2 BBS1 RAB3IP BBIP1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 CDC20 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 FBXO5 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B PIM1 NOX4 GAB2 GRB2 CDKN1A FLT3 BCL2L1 PTPN11 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C19 CYP2C9 CYP2U1 CYP4F2 CYP4A11 CYP2C8 CYP1B1 CYP1A2 CYP1A1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression GATA3 H2AX H3-3B H3C8 FOS H2AJ H3C15 TGFA CCND1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 FOSB BCL2 H2AB1 KPNA2 SMC3 H2AC8 H2AC6 H2AC7 GPAM ATF2 SP1 RAD21 STAG1 H2BC26 H2BC21 STAG2 NRIP1 EP300 H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 CREBBP SMC1A H2BC11 HSP90AA1 CARM1 YY1 H2AZ2 TNRC6C TNRC6A TNRC6B CCNT1 JUN MYB CBFB TBP RUNX1 GTF2A1 GTF2A2 CITED1 PRMT1 CDK9 HDAC1 KCTD6 ESR1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J PGR POLR2K POLR2L GTF2F1 KAT5 GTF2F2 AXIN1 KAT2B H2AC19 H2AC14 H2BC12L MYC HSP90AB1 CXCL12 FOXA1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD NCOA3 H4C9 NR5A2 TFF3 JUND TFF1 KANK1 CXXC5 MOV10 KDM4B AGO3 PTGES3 AGO4 USF2 H2AC20 USF1 AGO1 ZNF217 AGO2 EBAG9 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions ITGA2B ALCAM SCN11A DPYSL2 LAMA1 SCN9A NRCAM EPHB2 SCN1B SCN1A ANK2 ANK3 LAMB1 ANK1 LAMC1 SHTN1 SCN10A SCN8A RAC1 KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 SPTA1 NCAN SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN L1CAM KIF4B KIF4A ITGA10 CNTN1 CNTN2 CD24 SCN2A SCN2B PAK1 NRP2 CNTNAP1 SH3GL2 CHL1 SCN5A SPTAN1 LYPLA2 SPTB DNM1 DNM3 GAP43 DCX NUMB SCN4A SCN4B MAPK1 ITGA9 SCN7A NCAM1 MAPK3 RANBP9 MAP2K1 NFASC MAP2K2 RPS6KA6 HSPA8 DNM2 EGFR DLG1 DLG3 DLG4 RPS6KA5 ITGB1 CLTC CLTA ITGA2 ITGA1 SDCBP AP2A1 AP2A2 AP2M1 RPS6KA1 AP2S1 AP2B1 ITGAV VAV2 NRP1 CSNK2A1 CSNK2A2 CSNK2B ITGB3 ITGA5 RPS6KA3 RPS6KA2 RPS6KA4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SNRPD3 NCBP1 SNRPG NCBP2 LSM10 SNRPE SLBP ZNF473 LSM11 SNRPF SNRPB PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation H2AX TNRC6A TNRC6B JUN MAML2 MAML1 PRKCI H3-3B H3C8 RUNX1 H2AJ NOTCH1 NOTCH2 H3C15 NOTCH3 NOTCH4 CCND1 H2BC9 E2F1 H2BC8 H2BC5 E2F3 H2BC3 H2BC1 TFDP1 SNW1 TFDP2 SIRT6 H2AB1 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB H2AC8 H2AC6 H2AC7 TP53 KAT2B KAT2A MAMLD1 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 EP300 H2BC17 H2BC12 RBPJ H2BC13 H2BC14 H2BC15 CREBBP H2BC11 H4C9 MOV10 AGO3 H2AZ2 AGO4 H2AC20 AGO1 AGO2 ELANE TNRC6C DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 FGF9 FLRT1 FGF20 FGF23 FGF22 SOS1 PIK3R1 PIK3CA FGF10 NRAS GAB1 FRS3 FLRT3 HRAS PLCG1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FLRT2 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants FLT3 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB HADHA ACADL REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation MEAF6 BRPF1 ING5 MTA2 BRPF3 ING2 PIP4P1 TP53 BRD1 PIN1 PIP4K2A PIP4K2B KAT6A AKT2 AKT3 MBD3 AKT1 BRD7 EP300 GATAD2B GATAD2A HDAC1 HDAC2 CHD4 RBBP4 CHD3 RBBP7 MAP2K6 PML SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM POLR2I POLR2J POLR2K POLR2L FGFR2 GTF2F1 GTF2F2 NCBP1 NCBP2 POLR2A POLR2B FGF1 POLR2C FGF2 POLR2D POLR2E POLR2F POLR2G POLR2H TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses PRKAG1 PRKAG2 PRKAG3 RAC1 MDM2 SRC NRAS MAPK1 GRIN2B HRAS MAPK3 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE PDPK1 GIT1 PRKAA1 PRKAA2 CALM1 AP2A1 PRKACG PRKACB GLS SLC1A1 SLC1A2 RPS6KA1 SLC1A3 SLC6A3 SLC1A6 SLC5A7 SLC1A7 SLC38A2 SLC38A1 SLC6A12 GNGT1 GNGT2 GNAT3 ADCY9 PRKAR1B PRKAR2B GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ACTN2 ADCY8 GNG10 GRIN2C ADCY7 PRKAR2A ADCY6 PPM1E GNG3 GNAI1 PPM1F GRIN2D ADCY5 GNG2 GNAI2 GRIN1 GRIN2A GNG5 DLG2 GNG4 LRRC7 GNG7 CAMK4 GNG8 NEFL CAMK1 AKAP5 MYO6 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GAD1 GAD2 SNAP25 SYT1 VAMP2 STX1A GRIP1 RPS6KA6 NSF PRKCG CASK GABRG3 KPNA2 HSPA8 GABRG2 GRIP2 GRIA1 LIN7A LIN7C LIN7B ABAT EPB41L1 ARL6IP5 TSPAN7 GLUL GRIA3 UNC13B GRIA4 CACNA2D1 GRIN3B SLC6A13 GNAL CACNA2D3 GRIN3A CACNA2D2 NBEA SLC6A11 GABRB3 SLC22A2 GABRB2 COMT SLC22A1 GABRB1 ACHE RASGRF2 SLC6A1 RASGRF1 KIF17 SLC6A4 SLC18A2 NRGN GABRR3 SLC18A3 GABRR2 SLC32A1 DLG1 GABRR1 SYN3 DLG3 SYN2 DLG4 NPTN GRIK5 SYN1 HTR3E GRIK3 ALDH5A1 HTR3C GRIK4 SLC17A7 HTR3D GRIK1 BCHE HTR3A GRIK2 RAB3A NRG1 RIMS1 HTR3B NCALD ARHGEF9 PPFIA1 PICK1 PPFIA4 CAMKK1 PPFIA3 CAMKK2 PPFIA2 GLRA1 CACNB1 GLRA2 CACNB2 CACNB3 CACNG8 GLRA3 CACNB4 NAAA CACNG2 TOMT CACNG3 CHAT KCNJ2 CACNA1B CACNG4 CACNA1A KCNJ3 GABRA2 CACNA1E GABRQ CPLX1 DNAJC5 KCNJ4 GABRA1 GLS2 TSPOAP1 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GABRA6 GABRA5 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GLRB APBA1 PRKCB GRIA2 ALDH2 PRKACA PRKCA PLCB3 PLCB1 PLCB2 CAMK2B CAMK2D CAMK2A MAOA PRKAR1A PRKAB2 CAMK2G PRKAB1 RPS6KA3 RPS6KA2 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) TFPT MCRS1 INO80 COPS3 COPS6 ERCC4 ERCC1 ERCC5 CETN2 COPS8 LIG1 UBA52 RNF111 UBB UBC RPS27A RBX1 PIAS3 UBE2I ACTB XRCC1 LIG3 CUL4A CCNH DDB1 ACTL6A PIAS1 CUL4B DDB2 SUMO1 SUMO3 SUMO2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 COPS5 MNAT1 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 UBE2V2 GPS1 UBE2N PCNA POLD3 POLD4 COPS4 RUVBL1 POLD1 COPS2 NFRKB POLD2 PARP1 PARP2 ACTR5 USP45 RAD23A CHD1L ACTR8 RPA1 YY1 RAD23B RPA2 INO80C INO80B POLE4 INO80E INO80D XPA RPA3 COPS7B POLE2 COPS7A POLE3 XPC BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism HMGCS2 HMGCLL1 AACS ACAT1 HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis OCA2 SLC45A2 DCT TYRP1 TYR DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication MCM6 MCM2 H2AX ANAPC15 ANAPC16 KPNA1 ANAPC7 UBE2C LIG1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 H3-3B CDC16 ANAPC4 ORC5 H3C8 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 H2AJ ORC3 CCNA2 ORC2 CCNA1 H3C15 FZR1 H2BC9 H2BC8 H2BC5 SKP2 H2BC3 H2BC1 CCNE2 CCNE1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 CDC6 KPNB1 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 KPNA6 PSMB3 POLRMT UBC POLG2 PSMB1 RNASEH1 RPS27A CDT1 ADRM1 FEN1 SEM1 MCM10 POLG RBX1 TWNK PSMC5 DBF4 PSMC6 MGME1 PSMC3 EXOG PSMC4 PSMC1 RPA4 PSMC2 SSBP1 CDC7 POLE H2AC19 H2AC14 RFC5 H2BC12L RFC3 RFC4 RFC1 RFC2 TOP3A DNA2 PCNA POLD3 POLD4 POLD1 POLD2 H4C9 RPA1 GINS1 RPA2 GINS2 CDC45 POLE4 MCM7 GINS3 H2AC20 GINS4 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS2 EIF2S3 EIF2S2 EIF2S1 FAU EIF4EBP1 EIF4E EIF4B RPS27A EIF4G1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 PABPC1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 GYG2 GYS2 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling FGF9 FGF20 FGF23 FGF22 SOS1 FGF10 NRAS FRS3 HRAS FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) RAD1 ATM RAD9B ATR H2AX RAD9A LIG1 CCNA2 CCNA1 RNF4 H2BC9 H3-4 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CDK2 SIRT6 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ERCC4 HERC2 ERCC1 UBA52 UBB UBC RPS27A SEM1 PIAS4 UBE2I PPP4R2 TIPIN TIMELESS BRCC3 PPP4C CLSPN TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 MUS81 RNF8 MRE11 NSD2 BRCA1 RAD52 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE POLH GEN1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 UBE2V2 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 MDC1 RHNO1 BLM RTEL1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 H4C9 XRCC2 XRCC3 RPA1 RPA2 PALB2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 PPARA ATF2 CRTC2 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 NPAS2 HELZ2 RAI1 TGS1 NRIP1 EP300 TBL1X MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 NR1D1 SIRT1 NCOR1 TBL1XR1 RORA CARM1 RORC RORB BMAL1 CLOCK RXRA PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PLA2G4A PLCB3 PRKX PLCB1 ADCY2 PLCB2 CAMK2B ADCY1 CAMK2D ADCY8 GNAQ CAMK2A ADCY7 ADCY6 PRKAR2A ITPR1 ADCY5 PLCB4 ITPR2 ITPR3 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 GNA14 GNA15 GNA11 MAPK1 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AC6 H2AC7 RPS2 PBRM1 H2AX SMARCB1 DNMT3A H2AC17 H2AC12 PRMT7 PRMT5 PRMT3 ARID1A H2AC1 ARID1B WDR77 COPRS SMARCD3 H2AC19 SMARCC1 H2AC25 H2AC14 H3C8 SMARCC2 H2AC21 H2AJ ARID2 PRMT6 WDR5 PRMT1 H3C15 SMARCD1 SMARCD2 CCND1 JAK2 SMARCA2 SMARCA4 H4C9 CARM1 ACTL6B CDK4 RBBP7 ACTL6A H2AB1 SMARCE1 H2AZ2 H2AC20 H2AC8 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib HSP90AA1 CDC37 ERBIN ERBB2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD4 SMAD3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR UNC93B1 TLR8 TLR9 TLR7 TLR3 CTSV CTSS LGMN CTSL CTSB CTSK HSP90B1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 C3 C4A IGKV3-20 IGHV4-34 C4B_2 IGHV1-2 CFB IGHV1-46 C2 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHG3 IGHG4 IGHG1 IGHG2 FCN1 FCN2 FCN3 MASP1 CFD MBL2 CRP C1QB C1QA COLEC11 COLEC10 C1S C1R GZMM C1QC INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade INS SOS1 THEM4 KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 SHC1 GRB10 INSR NRAS GAB1 MAPK1 HRAS MAPK3 FRS2 FLT3 PTPN11 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib HSP90AA1 CDC37 ERBIN ERBB2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA CHUK TRIM21 UBA52 MYD88 RELA TICAM1 UBB NKIRAS1 NKIRAS2 UBC RPS27A NFKB1 NFKBIA CTNNB1 NFKBIB POLR2E POLR2F POLR2H TRIM32 ZBP1 POLR2K TBK1 POLR2L IRF3 NLRP4 MRE11 DTX4 NFKB2 TLR3 CRCP EP300 POLR3GL POLR3A POLR3B RIPK3 POLR3C CREBBP POLR3D POLR1C POLR3E POLR3F CGAS POLR1D DDX41 POLR3G LRRFIP1 POLR3H AIM2 IRF7 POLR3K TRIM56 PRKDC IKBKB DHX9 NLRC3 IFI16 DHX36 STAT6 XRCC6 IKBKG RIPK1 XRCC5 TREX1 STING1 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification PDCD1 PSMA5 PRKAG1 PSMA6 PRKAG2 PSMA3 PSMA4 PSMA1 MAGT1 PSMA2 CUL3 UBA52 PRKAG3 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 JAK1 PSMA7 PSMB6 PSMB7 PSMB4 PDCD1LG2 PSMB5 UBB PSMB2 B3GNT3 PSMB3 UBC PSMB1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 RBX1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 SPOP PSMC1 PSMC2 CCND1 MIB2 CDK4 TUSC3 NEK2 TMEM258 CD274 VCP SEL1L OST4 COPS5 OSTC STT3A STT3B RNF185 GSK3B PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 YWHAG CSNK2B RPN2 DDOST RPN1 DAD1 PRKAA1 PRKAA2 RNF5 ERLEC1 PSMD8 PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 BTRC SKP1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport SERPINA1 PPP6C TFG PPP6R1 PPP6R3 TMED2 CTSC TRAPPC2L LMAN1L F5 F8 NAPA TRAPPC6A NAPB TBC1D20 TRAPPC6B GORASP1 PREB LMAN1 GOLGA2 SEC22B NAPG STX5 SEC22A YKT6 SEC22C RAB1A TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 CNIH3 FOLR1 BET1 CTSZ AREG SEC23A NSF SAR1B GRIA1 SEC24B SEC24A SEC24D SEC24C CSNK1D SEC13 COL7A1 MCFD2 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants FLT3 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors H2AX MTA2 H3-3B H3C8 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 CHD5 H2BC3 IKZF1 IKZF2 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 ZNF532 H2AC8 H2AC6 H2AC7 G6PC1 H2AC19 H2AC14 H2BC12L NR2C2 MBD3 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 FBP1 H2BC15 HDAC2 H2BC11 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS CYP19A1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis DGKE DAGLA DGKD DGKB DGKA ABHD6 PRKCQ ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB PRKCD DGKK RASGRP2 DGKI DGKH ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 RASGRP1 MGLL DGKG LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CALM1 PRKACA CAMK4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling SPRED2 SPRED1 FGF23 FGF22 FGF18 FGF2 FGF10 FGF3 FGF4 FGFRL1 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle ARHGAP26 ARHGEF5 VAMP3 ARHGAP39 ARHGAP21 TFRC MCF2 MCAM ERBIN VANGL1 ARHGAP32 DIAPH3 TJP2 CAV1 VAV2 RTKN SOWAHC ARHGEF10L STK10 AKAP13 ROCK1 SLK ROCK2 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 STARD8 MYO9B RHOB SNAP23 FLOT1 CIT DAAM1 ARHGEF3 FLOT2 ARHGEF1 ARHGEF2 PKN3 PIK3R2 ARHGEF25 PIK3R1 ARHGEF28 ARHGAP1 IQGAP3 ARHGDIG STOM ARHGAP5 RHPN2 ARHGAP35 ECT2 PREX1 STARD13 OPHN1 JUP CAVIN1 BCR PCDH7 MCF2L MYO9A NET1 ANLN DIAPH1 ABR ACTC1 RACGAP1 DLC1 PKN2 PKN1 DEPDC1B ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 PAK5 PAK1 SOS1 PAK3 PAK2 NCK2 RAC1 NCK1 SLIT2 SOS2 PAK4 ROBO1 PAK6 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 RHOC ARHGEF5 TIAM2 OBSCN ARHGEF4 ARHGEF7 ARHGEF26 NGEF ARHGEF6 FGD1 FGD2 KALRN GNA13 FGD3 FGD4 TBXA2R GNA12 ARHGEF33 ARHGEF35 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 PLXNB1 VAV1 GNGT1 GNGT2 TIAM1 BTK SOS1 VAV3 VAV2 RASGRF2 GNG10 GNG3 ARHGEF18 GNG2 GNG5 GNG4 RHOA GNG7 ARHGEF10L GNG8 AKAP13 ROCK1 ROCK2 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 RHOB ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 ECT2 PREX1 SOS2 GNG12 MCF2L GNG11 GNG13 NET1 GNB2 ABR ARHGEF16 GNB1 GNB4 ADRA1D GNB3 ADRA1B GNB5 ADRA1A ARHGEF40 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids ACOT8 EHHADH HSD17B4 ACAA1 DECR2 ABCD1 SLC27A2 ACOT4 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease ETV6 FIP1L1 BIN2 KDR SOS1 PIK3R2 PIK3R1 PIK3CA STAT1 NRAS STAT3 WDR48 HRAS PDGFRA KANK1 PIK3CB GOLGA4 STRN S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase MCM6 MCM2 ANAPC15 ANAPC16 ANAPC7 UBE2C LIG1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ORC5 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 RB1 CDKN1A CDKN1B FZR1 CCND1 E2F1 SKP2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 SMC3 CDC6 CDCA5 PDS5B PDS5A RAD21 GSK3B WAPL STAG1 STAG2 SMC1A PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 CDC25B PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 FEN1 SEM1 RBX1 MAX PSMC5 PSMC6 ESCO1 PSMC3 ESCO2 PSMC4 PTK6 PSMC1 LIN54 PSMC2 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 CCNH CDK7 MNAT1 POLE RBL2 RFC5 RFC3 AKT2 MYC RFC4 AKT3 RFC1 AKT1 RFC2 DNA2 PCNA POLD3 POLD4 POLD1 POLD2 E2F4 E2F5 RPA1 GINS1 RPA2 GINS2 CDC45 POLE4 MCM7 GINS3 GINS4 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRA2C ADRB3 ADRA2B ADRA2A CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P HRH1 HTR6 ADRA1D HTR7 ADRA1B HRH3 ADRA1A HRH2 HRH4 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair RAD1 ATM RAD9B ATR H2AX RAD9A LIG1 CCNA2 CCNA1 RNF4 MAPK8 H2BC9 H3-4 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CDK2 SIRT6 KPNA2 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PARP1 PARP2 ERCC4 HERC2 ERCC1 UBA52 CHEK2 UBB UBC RPS27A FEN1 SEM1 PIAS4 UBE2I XRCC1 LIG3 PPP4R2 TIPIN TIMELESS BRCC3 PPP4C CLSPN SUMO1 TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 MUS81 RNF8 MRE11 NSD2 BRCA1 RAD52 BRCA2 EME1 KAT5 TP53 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE DCLRE1C POLH RIF1 GEN1 LIG4 RFC5 H2BC12L PAXIP1 RFC3 NHEJ1 RMI2 XRCC4 RFC4 SMARCA5 RFC1 SLX1B PPP5C TDP2 RFC2 TDP1 RMI1 UBE2V2 BAP1 TOP3A HUS1 UBXN1 POLL SPIDR BAZ1B RAD51B RAD51D APBB1 RAD51C KDM4A DNA2 POLQ MDC1 RHNO1 EYA1 BLM EYA2 RTEL1 POLM PCNA EYA3 RAD51AP1 EYA4 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 H4C9 XRCC2 PRKDC XRCC3 RPA1 RPA2 PALB2 KDM4B POLE4 RAD50 XRCC6 RAD51 XRCC5 RPA3 POLE2 POLE3 RAD17 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function TNRC6A TNRC6B SP1 ZEB2 ANGPTL4 CTNND1 HEYL CTNNB1 PRDM8 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 JUP ADAM19 ILF3 CDH11 SNAI1 MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis NEU1 CTSA GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 MAML2 MAML1 NEURL1 YBX1 EGFR KAT2B KAT2A MAMLD1 UBB PSENEN PSEN2 PSEN1 UBC APH1A HES1 NCSTN RPS27A APH1B HES5 HEYL NOTCH1 EP300 NOTCH3 RBPJ CREBBP HEY1 STAT1 HEY2 MIB2 SNW1 PLXND1 WWC1 FABP7 DLGAP5 EGF PTCRA PBX1 TACC3 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS SAP30 BRMS1 IFNAR1 FURIN PHF21A CD79B CD79A SUDS3 RCOR1 CUL3 IGHM BLNK HMG20B JAK3 IFNGR1 IFNGR2 SIGMAR1 TYK2 JAK1 IGHD SAP30L S1PR1 SAP18 CRBN STAT2 VAV1 SH3KBP1 ACE2 TUBB BRD4 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 ZBP1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 SOS1 IGKV2D-30 IGHV4-59 IGHV1-69 COMT IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 MBD3 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 GATAD2B GATAD2A IGKV3-20 ITGB1 IGHV4-34 IGHV1-2 IGHV1-46 TLR9 IGHV4-39 IGHV IGKV2-29 HDAC2 IGKV2-28 IGLC3 IGLC1 IGLC2 HSP90AA1 CHD4 RBBP4 CHD3 IGKV3D-20 IL6R NFE2L2 RBBP7 IGLV3-19 IGKV2-30 RIPK1 IGHV2-70 IGHV2-5 KEAP1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PDCD1 IGLV3-21 FKBP1A AP2A1 IGKV1-39 MTA2 IGKV1-33 AP2A2 IGHV3-53 REST IGLC7 IGKV5-2 IGKV1-5 AP2M1 IGLC6 RBX1 AP2S1 MTA1 HDAC1 MTA3 AP2B1 NR3C1 BTK PLCG2 ATP1B3 ATP1B2 SYK ATP1B1 IMPDH1 IMPDH2 ATP1A4 ATP1A3 ATP1A2 TLR7 ATP1A1 HSP90AB1 CYSLTR1 ROCK1 ROCK2 ITGA4 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 KDM1A FXYD6 JAK2 FKBP4 NCK1 PTGES3 ARID4A ARID4B FNTA FNTB IL1R1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs CSTF1 FIP1L1 PAPOLA SYMPK CPSF7 NCBP1 NCBP2 CPSF1 CPSF4 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PABPN1 PCF11 CLP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea KCNMB1 KCNMA1 CHRNA10 KCNN2 EZR SPTBN1 RDX MSN CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 SPTAN1 PLS1 TPRN TMC1 MYO7A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 USH1C ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 CASK GRXCR2 GSN WHRN LHFPL5 OTOGL TMIE USH1G STRC EPB41L1 MYO15A SLC26A5 CHRNA9 TWF1 MYH9 MYO1C DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS SFTPC IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR TGFA EGF EREG BTC AREG EPGN HBEGF EGFR POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription SP1 ARID1A TFAP2A RB1 KLF9 ZEB2 FOXJ2 STRAP FOXP2 KLF4 FOXA2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF9 FGF20 FGF23 FGF1 FGF2 FGFR1 FGF4 FGF6 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A5 SLC12A1 SLC12A6 SLC12A7 SLC12A2 SLC12A3 SLC12A4 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) PRELP ACAN KERA OGN OMD FMOD LUM B4GALT1 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 HSPA1A PSMD13 PSMA7 HSPB1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PABPC1 PSMB1 RPS27A ADRM1 SEM1 EIF4G1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 HSPA8 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors MASP1 CALR APOB COLEC11 FTL COL3A1 COL4A2 APOA1 COL4A1 APOE COLEC12 MSR1 COL1A1 SCARA5 COL1A2 MARCO SCGB3A2 FTH1 HSP90B1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol GSK3A CHUK CDKN1A CDKN1B TSC2 MDM2 AKT1S1 AKT2 GSK3B AKT3 BAD CASP9 AKT1 MKRN1 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids ACSM5 ACSM4 GLYAT ACSM1 GLYATL3 ACSM2B GLYATL2 GLYATL1 ACSM2A RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle CDC42EP1 GIT2 WWP2 ARHGAP26 RAB7A VAMP3 ARHGEF7 ARHGAP21 PAK4 TFRC SLC1A5 MPP7 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 PAK1 PAK3 PAK2 STEAP3 GJA1 WIPF2 CAV1 WASL WAS ARL13B CPNE8 DOCK8 SNAP23 FNBP1L FNBP1 SCRIB SYDE1 NIPSNAP2 RHOJ PIK3R2 TRIO PIK3R1 CDC42BPB CDC42BPA ARHGAP1 GIT1 IQGAP3 SLC4A7 STOM FMNL3 ARHGAP5 ARHGAP35 PREX1 OPHN1 OCRL JUP CDC42 TMPO DEPDC1B SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 HPN SPINT2 MST1R SPINT1 MST1 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions JUP CTNNB1 CDH11 CDH8 CTNND1 CTNNA1 CDH24 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism GOT2 FMO1 SUOX BHMT MTAP TST ADI1 CTH MTRR ETHE1 AHCY SLC25A10 CDO1 MTR MAT1A GADL1 APIP MRI1 CSAD ADO TXN2 CBS ENOPH1 MPST GOT1 TSTD1 BHMT2 SQOR PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU PELO ABCE1 RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins UBA52 UBE2E1 UBE2D1 CDC73 RNF152 SHPRH HLA-B RRAGA BCL10 PEX2 HLA-A RNF40 RNF144A SKIC8 SELENOS WAC UBE2J2 CTR9 RTF1 UBB TMEM129 HLTF UBC LEO1 PEX10 RPS27A PEX12 PEX13 DERL1 PEX14 PAF1 RNF181 H2BC9 UBE2D2 H2BC8 H2BC5 H2BC3 H2BC1 UBE2B RAD18 VCP UBE2V2 UBE2L3 UBE2N H2BC17 H2BC12 H2BC13 PCNA H2BC14 RNF20 H2BC15 H2BC11 UBE2D3 PRKDC UBE2A TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 PIK3R4 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PIK3C3 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA EEA1 DUSP6 TASL DUSP7 RBSN IRF5 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 SLC15A4 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry FURIN UBA1 AP2A1 AP2A2 GPC1 RPSA AP2M1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 CD14 ATG7 AGRN UBA7 UBA6 CD209 UBA5 SDC1 AP2S1 RNASEK HAVCR1 PROS1 CLDN1 MRC1 PIK3R1 EMC4 CD33 HSPA5 CD300A TIMD4 MERTK AP2B1 AXL TYRO3 MAPRE3 GAS6 LY6E UBA3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) ALOX5 DPEP2 DPEP1 MAPKAPK2 CYP4F2 GGT5 CYP4A11 LTC4S ABCC1 ALOX15 CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 LTA4H PTGR1 ALOX5AP GGT1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery POLR2I POLR2J POLR2K POLR2L ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation PMEL BCL7A MLANA BCL7C DPF1 MYO5A BCL7B DPF2 DPF3 SMARCB1 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 ARID1A GPR143 ARID1B SMARCD3 SMARCC1 SMARCC2 DCT TYRP1 AKT2 TYR CTNNB1 SOX10 TFAP2A SMARCD1 SMARCD2 LEF1 SMARCA2 ACTB SMARCA4 ACTL6A SMARCE1 MAPK14 USF1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 SGK2 STOML3 ATP10D ATP10B ATP10A ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TCIRG1 TPCN2 TPCN1 CLCN7 CLCN5 ATP6V1E1 CLCN4 ATP6V1E2 OSTM1 ATP6V0B ATP13A4 ATP6V1G1 ATP13A5 ATP6V0E1 ATP13A2 ATP6V1G2 UNC79 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 STOM CALM1 UBA52 UBB UBC RPS27A PDZD11 SGK1 NEDD4L RYR1 RYR2 ATP2A3 ATP2A2 ATP2A1 RYR3 SLN CLIC2 ATP1B3 ATP1B2 CLCN6 ATP1B1 TRDN ASPH ATP8A2 ATP8A1 CAMK2B ATP12A CAMK2D BEST2 CAMK2A SLC9C1 ATP1A4 BEST3 SLC9C2 ATP1A3 BEST1 BEST4 ATP1A2 ATP11C ATP11B ATP1A1 ATP11A SRI SLC9B1 PLN SLC9B2 SCNN1G CAMK2G SCNN1D SCNN1B SCNN1A ATP2B4 TTYH3 ATP2B3 TTYH2 ATP2B2 CLCNKB ATP2B1 WNK4 CLCNKA FXYD4 NALCN TRPM1 FXYD3 TRPM2 ASIC4 FXYD2 ASIC5 TRPM7 FXYD1 CLCA2 TRPM8 FKBP1B CLCA1 TRPM5 FXYD7 ASIC2 TRPM6 FXYD6 ASIC3 TRPM3 CLCA4 TRPM4 ASIC1 TRPC7 WWP1 ATP8B4 MCOLN3 ATP8B3 TRPC5 ATP8B2 TRPC6 ATP8B1 TRPC3 ATP4B TRPA1 ATP4A TRPC4 WNK1 TRPC1 TRPV2 WNK2 RAF1 TRPV3 WNK3 TRPV1 CUTC UNC80 MCOLN1 ATP7B MCOLN2 TRPC4AP ATP7A TRPV6 TSC22D3 TRPV4 ANO8 TRPV5 ANO9 ANO6 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors MITF SUMO2 FOXL2 HIC1 SP3 TFAP2B TFAP2C CDKN2A MTA1 TP53 PIAS4 PIAS3 MDM2 UBE2I PIAS1 SUMO1 SUMO3 TP53BP1 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 TFAP2A MYBL2 HSPD1 NPM1 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 APEH RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 HEMK2 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 TRMT112 RPL27 RPL26 GSPT2 RPL29 GSPT1 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 ETF1 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat POLR2I POLR2J POLR2K POLR2L CCNK GTF2H1 CCNT2 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions SHH HHIP BOC GAS1 PTCH1 CDON IHH DHH LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis PCNA POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RFC5 RFC3 RFC4 RFC1 RFC2 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA PLA2G4B PLA2G2A DDHD2 DDHD1 GNPAT LPCAT4 PLA2G10 GPD1 GPD1L PLA2R1 PLD1 PLA2G4A GPAM AGPAT5 PLA2G1B GPAT2 LPCAT1 PLA2G5 PLD6 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PLD2 LIPI GPAT4 ACP6 LIPH GPD2 GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 ALPI PLA2G4D MIGA1 ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion FURIN UBA52 TSG101 NMT2 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 UBB VPS28 UBC PPIA RPS27A ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility EREG BTC MEMO1 NRG2 HBEGF NRG3 EGFR NRG4 EGF DIAPH1 RHOA ERBB2 NRG1 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) SV2C SV2B SV2A VAMP1 VAMP2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity PRKAA2 ADIPOQ ADIPOR1 ADIPOR2 PRKAG2 STK11 PRKAB2 MLXIPL MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression MCM2 SMARCB1 LIG1 PLK1 CCNB1 SMARCC1 SMARCC2 ATP6V1E1 ATP6V0B ATP6V1G1 CDH1 ATP6V0E1 CTNNB1 MET ATP6V1B2 ATP6V0D1 CDKN1A ATP6V0C CDKN2A CCND1 ATP6V1A ATP6V1H SMARCA2 SMARCA4 ATP6V1C1 BCL2 CDK2 ACTL6A MAPK14 TCF7 GXYLT2 CDH2 STT3B SMARCD3 PXN TERT EDIL3 CEACAM1 ZEB1 SIN3A PXDN BIRC7 ASAH1 BCL2A1 TBX2 TFAP2A PPARGC1A SMARCD1 SMARCD2 ITGA2 SIRT1 LEF1 DIAPH1 TCF7L2 SMARCE1 TCF7L1 TNRC6C TNRC6A TNRC6B SERPINE1 CDC25B HINT1 DCT TYRP1 TYR POU3F2 SOX10 HDAC1 ACTB GMPR PMEL BCL7A MLANA BCL7C DPF1 MYO5A BCL7B DPF2 DPF3 BRCA1 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 ARID1A GPR143 ARID1B AKT2 SOX2 DICER1 TRPM1 MOV10 AGO3 AGO4 USF1 AGO1 AGO2 MCM5 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE TICAM1 TRAF3 TLR3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2I POLR2J POLR2K POLR2L PIWIL2 TDRKH PIWIL1 PIWIL4 DDX4 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 PLD6 FKBP6 HSP90AA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling HRAS SOS1 IRS1 IRS2 NRAS INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells CTNNB1 CBLL1 UBB UBA52 SRC UBC CTNND1 RPS27A CDH1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy ARL13B UBA52 PCNT CETN1 HSP90AA1 PARK7 RNASE1 HDAC6 GFAP LAMP2 PLIN2 CFTR HBB UBB PLIN3 HSP90AB1 UBC IFT88 RPS27A HSPA8 EEF1A1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals MT1E MT2A MT1A MT1M MT1F MT1G MT1X MT1H MT4 MT1B MT3 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair OGG1 NTHL1 NEIL3 NEIL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters LEF1 CTNNB1 AXIN2 MYC TCF7 TCF7L2 TCF7L1 RUNX3 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle POM121C NUP42 NUP62 FURIN TPR BANF1 NUP88 RAE1 KPNA1 NUP214 LIG1 NDC1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP107 NMT2 NUP160 NUP85 XPO1 SEC13 NUP133 PDCD6IP RANGAP1 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PPIA CD4 RCC1 NUP43 NMT1 CCR5 CCNK CHMP2B RANBP1 CCNT2 CHMP2A ELL CCNT1 RANBP2 GTF2B UBA52 TAF7L ELOA RAN ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 UBB CTDP1 TAF9 SUPT4H1 UBC TAF1L GTF2E1 GTF2E2 RPS27A NUP37 TAF15 FEN1 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 NEDD4L CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 LIG4 XRCC4 CXCR4 TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 CHMP5 NUP205 XRCC6 POM121 XRCC5 NUP188 PSIP1 AAAS DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 AKT1 DCP2 MAPK11 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC CASP3 UNC5A DAPK1 MAGED1 UNC5B DAPK2 DAPK3 APPL1 CASP9 DCC LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome WDR5 RBBP5 ASH2L DPY30 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2CA PPP2CB ATM PPP2R1B PPP2R1A PHF20 UBA52 CHEK2 TP53 MDM2 MDM4 USP7 CCNG1 USP2 CDK1 PRR5 AKT2 UBB AKT3 CCNA2 UBC AKT1 CCNA1 RPS27A MLST8 PDPK1 SGK1 MAPKAP1 RICTOR CDKN2A PPP2R5C RNF34 DAXX RFFL CDK2 MTOR INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TKT TALDO1 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS EXT1 EXT2 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 AGRN MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase CEP57 CETN2 PLK1 CEP164 ACTR1A CCNB1 PCM1 CNTRL CDK1 CEP290 NINL NEK9 NEK6 NEK7 OFD1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 ERCC6L CEP63 NUP107 ZWILCH NEK2 BUB1B SFI1 SMC3 CDC20 SDCCAG8 PPP1CC PPP2R1B PPP2R1A KNTC1 DCTN2 KNL1 SSNA1 SGO1 DCTN3 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 HAUS8 ZW10 HAUS7 MAD1L1 CDCA5 PCNT CDCA8 PDS5B CEP152 PDS5A PMF1 CSNK1E NUP160 SKA1 SKA2 CCNB2 NEDD1 DSN1 NUP85 ALMS1 RAD21 RCC2 NDC80 WAPL CEP41 ZWINT CEP43 STAG1 XPO1 KIF18A STAG2 RPS27 AHCTF1 YWHAG PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 HSP90AA1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 YWHAE DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP SMC4 CENPQ SMC2 SPC24 TUBGCP2 MAD2L1 NCAPG CENPS NCAPH NUP37 TUBGCP5 SPC25 TUBGCP6 TUBGCP3 CPAP TUBGCP4 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 NCAPD2 AKAP9 PRKAR2B TUBA4A PRKACA FIRRM CCP110 CEP250 CDK5RAP2 CEP135 CEP131 EML4 CSNK1D TUBA1A CSNK2A1 CSNK2A2 CSNK2B CEP70 CEP72 CEP192 CEP76 CEP78 PLK4 ODF2 TUBB4B TUBB4A RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCB NCF2 NCF4 NOXA1 NOX3 RAC2 PIK3C3 NOX1 S100A9 S100A8 PRKCD PRKCA RAC1 CYBB PIN1 MAPK1 CYBA MAPK3 NOXO1 PIK3R4 PRKCZ MAPK14 MAPK11 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 TREX1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACADS ECHS1 ACSM3 ACSM6 HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) H2AC6 H2AC7 H2AX KDM5B H3-3B H2AC19 H2AC14 KDM6B H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 KDM5A UHRF1 KDM6A H2BC1 H4C9 STPG4 AICDA METTL23 DPPA3 TET3 H2AB1 H2AZ2 H2AC20 H2AC8 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia PROS1 PROC F5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR2K POLR2L POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation IFNA8 IFIH1 RNF135 TBK1 TRIM25 IFNA21 IRF3 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI TANK IKBKE EP300 TRIM4 IFNB1 CREBBP TRAF2 IRF7 TRAF6 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events ANO7 ANO4 ANO5 FURIN ANO2 ANO3 ANO1 MAGT1 UBA52 ANO10 UBB UBC RPS27A PRMT1 TMPRSS2 ACE2 UBE2I ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 TUSC3 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 SUMO1 MGAT5 ST3GAL4 GSK3A MGAT1 PARP6 MGAT2 GOLGA7 PARP4 TMEM258 ST3GAL1 GALNT1 ST3GAL2 PARP16 PARP9 ST3GAL3 ST6GAL1 PARP14 PARP8 EDEM2 MOGS PARP10 ZDHHC11 MGAT4C ZDHHC9 SRPK2 MGAT4A OST4 SRPK1 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 OSTC STT3A CSNK1A1 STT3B GSK3B RPN2 DDOST RPN1 DAD1 CANX ANO8 ANO9 ANO6 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u DPM1 DPM2 DPM3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 CHUK UBE2N UBE2V1 UBA52 RIPK3 UBE2D1 UBE2D2 TICAM2 UBE2D3 TICAM1 IKBKB TLR4 LY96 BIRC2 UBB TRAF6 CD14 BIRC3 UBC RIPK1 IKBKG RPS27A RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry FURIN SDC1 GPC1 CX3CR1 HSPG2 EGFR RAB5B GPC3 RAB5C IGF1R GPC2 SDC4 NCL SDC2 GPC5 RAB5A SDC3 GPC4 TLR4 GPC6 LY96 CD14 AGRN RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 H2BC17 H2BC12 H2BC13 NEIL3 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes CYB5R2 CYB5R1 CA1 CYB5R4 CA2 HBB CA4 SLC4A1 CYB5RL RHAG AQP1 HBA2 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNMB1 KCNA10 KCNMA1 HCN4 HCN3 KCNN2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNQ2 KCNA7 KCNQ3 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK6 KCNK2 KCNK7 HCN2 KCNK1 KCNK3 HCN1 KCNK4 KCNQ4 KCNJ8 ABCC8 KCNJ2 KCNJ3 KCNJ4 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 KCNJ12 KCNJ9 KCNJ15 KCNJ16 GNGT1 GNGT2 ABCC9 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNG1 KCNJ11 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 KCNN1 KCNN3 GNB2 KCNN4 KCNF1 GNB1 KCNC1 GNB4 KCNK9 GNB3 KCNC2 GNB5 KCNC3 KCNC4 KCND1 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction CALM1 ANXA2 PXN TRIM72 GUCY1B2 GUCY1B1 ALDH2 ITGB5 DYSF LMOD1 MYL6B CACNA1H MYL12A PAK1 MYLK MYL12B CACNA1G CACNA1I CALD1 ANXA6 PAK2 MYL10 MYH11 GUCY1A2 GUCY1A1 ANXA1 CAV3 TPM4 ITGA1 TPM3 MYL11 PDE5A TPM2 TPM1 SORBS1 SORBS3 MYL5 MYL6 TLN1 MYL7 VCL MYL9 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 HSP90AA1 CDC37 HRAS SOS1 ERBIN PTPN12 ERBB2 SHC1 NRAS RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) CR1 TNFRSF18 NFATC2 CBFB IFNG RUNX1 CTLA4 IL2RA FOXP3 IL2 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b MOGS DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG GALE MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation CHUK FBXW11 UBA52 CUL1 MAP2K4 TNIP2 MAP2K1 IKBKB UBB UBC IKBKG BTRC RPS27A MAP3K8 NFKB1 SKP1 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction HCK DOCK2 ELMO1 FYN PAK2 LCK RAC1 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins NOTCH1 NOTCH2 NOTCH3 NOTCH4 POMT2 SEMA5A GALNT12 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTS4 ADAMTSL1 LFNG ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 DAG1 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 MUC13 THSD7A MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 POMGNT1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 B4GAT1 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 MUC16 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling BTK ARHGEF6 PLCB3 PLCB1 PLCB2 GNG10 GNG3 GNG2 GNG5 AKT2 GNG4 GNG7 AKT3 RHOA GNG8 AKT1 PIK3CG PAK1 PDPK1 PIK3R6 PIK3R5 GNGT1 GNGT2 CDC42 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification MGST1 DPEP2 MGST2 CYP3A4 DPEP1 ACY1 AKR7L CYP3A5 AKR7A2 AKR7A3 GGT3P GGT5 CYP2A13 CYP1A2 ACY3 GGT7 GGT6 MGST3 GGT1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events MAPK7 NRAS MAPK1 HRAS MAPK3 DGKG DGKE DAGLA DGKD DGKB DGKA PRKCQ ABHD6 SOS1 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI RASGRP2 DGKH TRIO ARHGEF25 PIK3CA ADRA1D RASGRP1 ADRA1B ADRA1A APP KALRN TBXA2R EDNRB RPS6KA1 EDN1 EDN3 GNGT1 CHRM3 CHRM1 GNGT2 CHRM5 HTR2B HTR2C HTR2A HRH1 MGLL BTK GPR143 GNAQ GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CYSLTR1 CYSLTR2 GCGR GNA14 GNA15 GNA11 GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 PLCB4 HBEGF ANXA1 EGFR NPFFR2 NPFFR1 RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 NTSR2 GPR17 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 OXTR QRFP MLN AVPR1B BRS3 GPRC6A OXT GPR132 AVP CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 SAA1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 GRK2 PRKCD PRKCA RGS5 PLCB3 RGS2 PLCB1 RGS3 PLCB2 RGS1 GHSR CASR F2R LTB4R2 UTS2 ITPR1 NTS ITPR2 KNG1 MCHR2 ITPR3 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 GRM5 MCHR1 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 PIK3R3 XCL2 PIK3R2 XCL1 PIK3R1 RGS18 RGS17 RGS19 RGS13 TRPC7 RGS16 P2RY6 RPS6KA3 P2RY2 RPS6KA2 TRPC6 P2RY1 TRPC3 RGS21 CCK HCRTR2 HCRTR1 KISS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules CD4 HLA-DRB3 HLA-DRB1 PLCG2 CD3G CD3E CD3D WAS TRAV19 HLA-DPA1 HLA-DRA VASP TRBC1 ENAH HLA-DQB2 HLA-DQB1 TRBV12-3 PAK1 TRBV7-9 PAK3 PAK2 LCK NCK1 TRAV29DV5 HLA-DQA2 EVL HLA-DRB5 TRAV8-4 HLA-DRB4 HLA-DPB1 PLCG1 ITK FYB1 ZAP70 TRAC LCP2 LAT GRAP2 CD101 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin VWF F2 F8 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs CDH11 TNRC6A TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 PDPK1 GAB2 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 SYK PIK3R2 PIK3R1 LYN LAT2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDK6 CDK4 CDKN2A SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis DLD OGDH DLST KGD4 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 MCCC1 PPM1K AUH IVD HIBCH ECHS1 ACAT1 BCKDK BCKDHA DBT BCKDHB DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants ITGA2B CALM1 FN1 CAMK2B CAMK2D CAMK2A SRC CAMK2G ITGB3 ARAF ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling NOTCH1 RBX1 CUL1 SKP1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching PCNA POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RFC5 RFC3 RFC4 RFC1 RFC2 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ITGA2B H2AX TNRC6A TNRC6B ASH2L GATA1 ZFPM1 H3-3B CBFB H3C8 RUNX1 H2AJ PRMT6 KMT2D PRMT1 GP1BA H3C15 KMT2B NFE2 HDAC1 H2BC9 H2BC8 H2BC5 SETD1B H2BC3 SETD1A H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 PRKCQ NR4A3 KMT2A KMT2C KAT2B H2AC19 H2AC14 H2BC12L SIN3B THBS1 DPY30 SIN3A H2BC26 H2BC21 WDR5 EP300 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H4C9 RBBP5 MOV10 AGO3 PF4 H2AZ2 AGO4 MYL9 H2AC20 AGO1 TNRC6C SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression PRDM1 TP53 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function ADAM33 ADAM19 JUP CTNNB1 CDH11 ANGPTL4 CDH8 CTNND1 CTNNA1 CDH24 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex TAB3 TAB2 TAB1 TICAM1 UBB TRAF6 UBA52 TLR3 UBC RPS27A MAP3K7 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis DNA2 PCNA LIG1 POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RFC5 RFC3 RPA1 RPA2 RFC4 RFC1 RFC2 RPA3 FEN1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL HCK RAPGEF1 CRK PIK3R3 SYK PIK3R2 BLNK PIK3R1 PIK3CA CRKL LYN YES1 FYN VAV1 PIK3CD PIK3CB CBL GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN KDM8 STS OGFOD1 EIF5A F8 ARSA JMJD4 DHPS FN3KRP JMJD7 SUMF2 SUMF1 JMJD6 TPST2 F7 TPST1 F9 RCCD1 EIF5A2 PROZ DNAJC24 ARSL DPH1 ARSJ DPH2 ARSK DPH3 ARSH ARSI DPH5 ARSF ARSB DPH6 ARSG PROS1 DPH7 ARSD ZC3H15 RPL8 RWDD1 FN3K ICMT F10 DOHH RIOX1 GGCX RIOX2 DRG1 GAS6 DRG2 F2 PROC EEF2 RPS6 ASPH BGLAP U2AF2 RPL27A RPS23 ETF1 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGF NGFR HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA SET ANP32A TNFSF13 NUP214 ELAVL1 PRKCD PRKCA XPO1 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation EIF5A2 EIF5A DHPS DOHH MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E UBB UBA52 UBC RPS27A REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade VTN CD59 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 CD81 V3-3 C4BPA V2-17 C4BPB V3-2 CLU IGHV3-33 V2-15 SERPING1 IGKV1D-39 CPB2 V2-19 CFH IGKV1D-33 C5AR2 C5AR1 IGKV2D-28 CFI IGKV4-1 C6 IGHV7-81 C7 C9 CD19 V1-11 C8B IGKV2D-30 C8A V1-16 C8G V1-13 CR2 IGHV4-59 CD46 IGHV1-69 CPN2 CPN1 CFHR2 IGLV2-11 CFHR1 IGLV1-40 CFHR4 IGLV1-47 CFHR3 IGLV6-57 CFHR5 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CR1 C3 C4A IGKV3-20 C5 IGHV4-34 C4B_2 IGHV1-2 CFB IGHV1-46 C2 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 ELANE IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PROS1 F2 C3AR1 IGHG3 IGHG4 IGHG1 IGHG2 CD55 C1QB C1QA C1S C1R C1QC CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis CD3G CD3D TFRC SYNJ1 SH3GL3 SH3KBP1 STAM CBL HGS EPS15 TGFA STAM2 SYT2 SH3GL2 SH3GL1 SYT1 EREG BTC DNM1 VAMP2 EPGN DNM3 HBEGF NEDD8 CLTB EGF AREG HSPA8 TF M6PR DNM2 VAMP8 VAMP7 DNAJC6 EGFR COPS5 SCARB2 ITSN2 SLC18A3 AGFG1 GAPVD1 BIN1 AMPH GRK3 CLTCL1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A SYNJ2 TOR1B APOB SYT9 FNBP1L SYT8 FNBP1 SNAP91 DAB2 AAK1 IL7R PICALM CLTC ITSN1 STON1 CLTA STON2 PIK3C2A SLC2A8 SGIP1 EPS15L1 OCRL ARFGAP1 EPN1 EPN2 GAK CFTR CTTN ARF6 LRP2 FCHO1 FCHO2 REPS2 UBQLN1 UBQLN2 COPS7B HIP1R COPS7A SNX18 NECAP2 CD4 NECAP1 SYT11 TRIP10 COPS3 COPS6 AP2A1 AP2A2 VAMP3 COPS8 UBA52 VAMP4 LDLRAP1 AP2M1 AGTR1 TGOLN2 UBB UBC IGF2R RPS27A AP2S1 AVPR2 LDLR AVP CHRM2 AP2B1 TACR1 ADRB2 WNT5A ARPC1A WASL GRK2 RAB5B RAB5C RAB5A HIP1 GPS1 DVL2 FZD4 ARRB1 ARPC4 ARPC5 ARRB2 ARPC2 ARPC3 COPS4 COPS2 ACTR3 ACTR2 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate SUOX TST ETHE1 SLC25A10 TSTD1 SQOR HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones SAP30 BRMS1 H2BC18 PHF21A MTA2 SUDS3 HDAC10 REST RCOR1 HMG20B SAP30L SAP18 H3C8 H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC8 H2AC6 H2AC7 H2AC17 H2AC12 NCOR2 H2AC1 HDAC3 H2AC19 H2AC25 H2AC14 H2AC21 MBD3 GPS2 H2BC26 H2BC21 GATAD2B TBL1X GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 KDM1A HDAC2 H2BC11 HDAC8 NCOR1 TBL1XR1 H4C9 CHD4 RBBP4 CHD3 RBBP7 ARID4A ARID4B H2AC20 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle GOT2 SLC25A18 MDH1 MDH2 SLC25A12 SLC25A11 SLC25A22 SLC25A13 GOT1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine GLYAT ACSM1 GLYATL3 ACSM2B GLYATL2 GLYATL1 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription RETN INS FASLG STK11 SFN SOD2 FOXO3 IGFBP1 PCBP4 ABCA6 BCL2L11 GADD45A CITED2 YWHAZ FOXG1 FOXO6 NPY CDKN1A FOXO4 CDKN1B BBC3 FOXO1 HDAC1 ATXN3 YWHAB PCK1 POMC NR3C1 MSTN SMAD2 CAV1 PLXNA4 SMAD4 SMAD3 SIRT3 BTG1 SREBF1 FBXO32 G6PC1 BCL6 NFYA NFYB NFYC GCK KAT2B CCNG2 RBL2 AKT2 AKT3 SIN3A AKT1 TRIM63 YWHAG EP300 PPARGC1A AGRP HDAC2 CREBBP SIRT1 DDIT3 YWHAQ TXNIP TXN PINK1 KLF4 CAT THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PLK1 UBA52 TP53 PSMD12 GTSE1 PSMD11 FKBPL PSMD14 PSMD13 CCNB1 PSMA7 PSMB6 CDK1 PSMB7 CCNB2 PSMB4 PSMB5 UBB PSMB2 PSMB3 HSP90AB1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 HSP90AA1 PSMD8 PSMD6 MAPRE1 PSMD7 PSMD2 PSMD3 PSMD1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP2B CHMP2A PIK3C3 BECN1 UVRAG MAP1LC3B ISCU CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PIK3R4 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly H2AX CENPT CENPU CENPH CENPI HJURP CENPK RSF1 CENPL MIS18BP1 CENPM OIP5 CENPN CENPW CENPX CENPO MIS18A CENPP H2AJ CENPQ CENPS H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KNL1 NPM1 H2AC19 H2AC14 H2BC12L SMARCA5 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RUVBL1 H4C9 RBBP4 ITGB3BP RBBP7 H2AZ2 CENPA H2AC20 CENPC VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release CALR CANX ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2AC6 H2AC7 H2AX H3-3B H2AC19 H2AC14 H3C8 H2BC12L KLK3 H2AJ KLK2 KDM4C H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 NCOA2 KDM1A H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 H2AB1 H2AZ2 PKN1 AR H2AC20 H2AC8 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation POLR2I POLR2J POLR2K POLR2L FGFR2 GTF2F1 GTF2F2 NCBP1 NCBP2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import UBA52 HMGCL UBE2D1 PEX2 ACOT8 UBB EHHADH HSD17B4 ACAA1 UBC PECR DECR2 PEX10 ZFAND6 RPS27A PEX12 IDE SLC27A2 PEX13 CROT ACOT4 PEX14 PEX26 SCP2 NUDT19 MPV17 GSTK1 PHYH ECH1 PIPOX PEX1 BAAT PEX7 ACOX2 ACOX1 UBE2D2 PEX6 AGPS ACOT2 ACOX3 AGXT PAOX DDO HACL1 HAO1 HAO2 IDH1 NOS2 EPHX2 TYSND1 LONP2 DHRS4 NUDT7 AMACR DAO CRAT GNPAT USP9X UBE2D3 CAT GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling CSH1 STAT5A PRLR PTPN6 STAT5B GHR GH2 SOCS2 GH1 ADAM17 SOCS3 SOCS1 JAK2 STAT1 LYN STAT3 MAPK1 MAPK3 IRS1 PTPN1 IRS2 CISH PRL TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses GJA10 GJC1 PANX1 GJD2 PANX2 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease EZH2 CD3G MAGT1 RAC1 JAK1 H3C8 VAV1 H3C15 RICTOR PAK2 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 ATP6V1H H2BC1 TUSC3 NEK2 H2AC8 H2AC6 H2AC7 ZBP1 TBK1 TMEM258 IRF3 VCP OST4 NFKB2 OSTC STT3A STT3B PRR5 GSK3B H2BC26 H2BC21 MLST8 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 LCK H2BC11 CDC42 RBBP4 FYN RBBP7 PTPN11 MTOR CD4 PTPN6 PDCD1 HDLBP AP2A1 CCNK CCNT2 AP2A2 ELL CCNT1 PRKACG GTF2B TAF7L ELOA PRKACB ELOB NELFB AP2M1 ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 ELOA2 SSRP1 AP2S1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 AP2B1 GJA1 ACTB P4HB ENO1 HSPG2 SDC4 SDC2 SDC3 LIG4 XRCC4 SDC1 NUP205 ARID4A POM121 ARID4B FNTA NUP188 FNTB PSIP1 AAAS IL1R1 SAP30 POM121C BRMS1 NUP42 NUP62 IFNAR1 PHF21A TPR BANF1 CD79B NUP88 CD79A RAE1 SUDS3 KPNA1 RCOR1 IGHM NUP214 NDC1 BLNK HMG20B NUP210 JAK3 NUP155 GPC1 HMGA1 IFNGR1 NUP153 IFNGR2 SIGMAR1 NUP93 GPC3 NUP50 TYK2 IGHD NUP35 GPC2 NUP54 SAP30L SLC25A5 S1PR1 SLC25A4 SAP18 GPC5 CRBN SLC25A6 GPC4 STAT2 GPC6 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 AGRN CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 RPL4 PAPOLA SYMPK RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 TKFC RPL35 KPNA4 RPL38 KPNA5 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPS4Y2 RPS4Y1 RPL39L CPSF4 RPL41 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 CDC73 HSPA1A HLA-B SKIC8 RUNX1 CTR9 TRAF3 RTF1 CD14 IKBKE LEO1 PAF1 FASN RNASEK PROS1 CLDN1 HNRNPU MTA1 MRC1 EMC4 CD33 MTA3 HSPA5 CD300A TIMD4 MERTK EIF4A3 AXL TYRO3 MAPRE3 GAS6 LY6E CDC40 SRRM1 SRSF2 SRSF3 GSK3A SRSF4 PARP6 SRSF5 PARP4 SRSF6 GALNT1 SRSF7 PARP16 PARP9 SRSF9 PARP14 PARP8 PARP10 PRKG2 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 PRKAR1A TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 CHMP5 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 ANO10 HLA-A B2M AP1M2 AP1M1 TUFM UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 V1-11 IGKV2D-30 V1-16 NMT2 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 CSNK1A1 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CD209 UBE2N TAB3 TAB2 TAB1 ITGB1 IGKV3-20 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 ELMO2 RCC1 IGKC DOCK2 NMT1 IGLV3-21 DOCK1 CCR5 IGKV1-39 IGKV1-33 RAB7A RANBP1 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YWHAH YWHAZ PPP1CB HDAC1 PPP1CA CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 VAV3 IFNA17 SIKE1 PTK2 MAVS IFNA10 RIGI SRPK2 SRPK1 CX3CR1 VAV2 RAB5B IMPDH1 RAB5C IGF1R NCL IMPDH2 PRKAR2A RAB5A NRP1 HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 MYO9B ACTG1 CPSF7 NCK1 VIM HNRNPC RBMX FURIN DPM1 DPM2 DPM3 RPTOR PGK1 EIF4E EIF4G1 STX1B SNAP25 TMPRSS2 ACE2 SYT2 SV2C HAVCR1 SYT1 ELK1 SV2B SV2A VAMP1 VAMP2 STX1A HBEGF ARF1 SEC23A SAR1B HSPA8 SCAP SEC24B SEC24A COMT SP1 SEC24D SEC24C PIK3R4 CASP4 CASP1 TLR9 PIK3C3 PDCD6IP RIPK3 IL18 IL1A IL1B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 IL6R RIPK1 KEAP1 UBE2L6 GSDMD HERC5 ITCH CHMP2B CHMP2A RNF213 ATG7 TRIM4 F2 AHCYL1 PRKACA ATP1B3 ATP1B2 ATP1B1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ATP1A3 ITPR2 ATP1A2 ITPR3 ATP1A1 CAMK2G CUL5 UBA7 UBA6 UBA5 UBR4 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 MAP2K4 TXN MAP2K7 UBA3 UBA1 IL6 MAPK8 IFNB1 VHL PLCG1 ELAVL1 C4BPA C4BPB BCL2L1 CLU EEF1A1 EEF2 ADAM17 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 NCKAP1 C3 C4A BRK1 C4B_2 GUCY2C CYBA NOXO1 NCKAP1L WASF1 WASF2 BAIAP2 H2BC18 ABI2 NOXA1 ABI1 NOX1 BECN1 UVRAG MAP1LC3B ISCU HCK CD8B ELMO1 ACOT2 UPK1A EPCAM ST6GALNAC2 PRKCSH CYFIP2 ZDHHC20 ZDHHC5 WIPF1 NOS2 ZDHHC8 WIPF2 ZDHHC2 WIPF3 ZDHHC3 GNAT3 C3AR1 FUT8 GANAB ENTPD1 ENTPD5 MAN2A1 MGAT5 ADCY9 PRKAR1B ST3GAL4 BTK MGAT1 MGAT2 MEFV PRKAR2B GOLGA7 PLCG2 ST3GAL1 MYO5A ST3GAL2 ST3GAL3 ARPC1B GBP6 ST6GAL1 ARPC1A LARP1 EDEM2 WASL GRPEL1 MOGS CTSG HYOU1 SYK ZDHHC11 MED19 GNAI3 MGAT4C MED18 ZDHHC9 ADCY4 PQBP1 MGAT4A WAS MED11 ADCY3 MGAT4B MED29 PRKX MAN1B1 MED28 ST6GALNAC3 ADCY2 MED22 ST6GALNAC4 ADCY1 MED21 ADCY8 ATL2 ADCY7 SRRT ADCY6 VPS33A GNAI1 VPS33B ADCY5 ZCRB1 GNAI2 SNRNP200 NT5E CORO1A PYCARD G3BP1 IGHG3 G3BP2 IGHG4 FUS IGHG1 NACA CYSLTR1 ISY1 IL10 IGHG2 BCAS2 CYSLTR2 CD163 CTNNBL1 GGT1 PLK2 PRCC DPEP2 RHBDF2 HNRNPA1 DPEP1 MYH9 HNRNPA0 GNAZ HNRNPA3 NCKIPSD GPKOW DVL1 CNBP DVL2 CDC5L DVL3 KDELR1 NLRP3 CCAR1 GGT5 ARPC4 CD2BP2 ARPC5 PCBP1 ARPC2 PCBP2 ARPC3 RBM10 MED13L PSTPIP1 FCGR3A BST2 ACTR3 CALM3 ACTR2 RETREG1 CALM2 FGR SUGP1 MYH2 ADORA2B DHX15 FCGR1A DHX16 UFD1 WASF3 MYO10 ARIH1 SFTPD P2RX7 BCAP31 P2RX4 TXNIP FCGR2A PEX19 MYO1C NLRP12 HNRNPA2B1 SUGT1 IL17F TRIM27 IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG PPIB RTN3 DDX3X DDX46 DDX42 SFN RBM17 LIG1 SUN2 DYNLT1 BUD31 MMP9 SFPQ RBM22 DDX23 RRBP1 SMNDC1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM HNRNPK NPLOC4 HNRNPF HNRNPD CLINT1 MED16 SF3B4 MED15 SF3B5 MED17 SF3B2 SF3B3 MED12 SF3B6 MED14 SF3B1 MED13 SF3A3 SF3A1 SF3A2 MED10 XAB2 PHF5A HSPA1B CLEC4M AUP1 IPO7 CD9 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 MED27 P4HA2 MED26 P4HA3 RCAN3 EIF4G3 MED23 EIF4G2 MED25 EIF4E3 MED24 DUSP16 PTBP1 MED20 PLRG1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 VPS41 EGFR NPIPB3 VPS45 PPIL3 PPIL4 PPIL6 SRRM2 AQR HLA-H HLA-C HLA-F CRNKL1 HLA-G MBD3 HLA-E NMI PRPF19 CHMP1A TOMM70 IL17RC IL17RA TLR1 GATAD2B HNRNPH1 GATAD2A HNRNPH2 TLR6 TLR2 SPCS3 SPCS2 SPCS1 CWC25 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 PSMD8 OAS2 IKBKB LTF PSMD6 GBP2 PSMD7 GBP4 PSMD2 NHERF4 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RIPK2 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NFKBIB MED30 NOD1 NOD2 MED31 IRAK2 UBE2I NR3C1 SUMO1 ITGA4 CCNC TRIM28 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 HGS CTNNB1 EPS15 CBLL1 MET STAM2 SH3GL2 SH3GL1 TUBB YWHAB MAPK1 SNW1 MAPK3 MAP2K1 MAP2K2 MAPK14 CTSL EXOC1 SOS1 CRK NPM1 GBF1 HDAC3 LY96 HBB XPO1 HMOX1 EP300 TBL1X IRAK1 MED1 CREBBP APOA1 HBA2 NCOR1 TBL1XR1 CHD4 CHD3 TLR4 NFE2L2 YWHAQ PPIA FKBP1A CALM1 MTA2 YWHAE COG1 REST JUN MED8 MED4 MED6 MED7 RBX1 NEDD4L GNGT1 GNGT2 WNT5A NCOR2 TAL1 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GPS2 XRN1 FZD7 KDM1A FKBP4 DDX5 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 CUL3 NRBP1 RB1 ABL1 DAXX NUP107 PPP1CC CDK8 DYNC1LI1 DYNC1LI2 NUP160 NUP85 RPS27 SEC13 NUP133 HDAC2 DYNLL1 RANGAP1 DYNLL2 DYNC1I2 TXNRD1 PML NUP43 DYNC1I1 RANBP2 DYNC1H1 TAOK1 NUP37 FEN1 PRMT1 EIF4A2 EIF4A1 TJP1 CCNH RNMT POLR2A POLR2B POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 YBX1 CDK7 ERCC3 H2AC17 ERCC2 H2AC12 MNAT1 H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 AKT2 TLR8 TLR7 AKT3 TLR3 AKT1 CSNK2A1 CSNK2A2 CSNK2B MASP1 MBL2 RPN2 MAPKAP1 C1QA RPN1 C1S PIK3R1 JAK2 CGAS LYN YES1 IRF7 H4C9 DHX9 XRCC6 XRCC5 H2AC20 STING1 CD28 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 EXT1 EXT2 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 AGRN RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR ELF1 CBFB RUNX1 IL3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX5 ALOX12 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis DICER1 ELAC2 ANG CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A3 SULT1A2 SULT2A1 SULT1C4 TPST2 TPST1 PODXL2 ABHD14B SULT1A1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNK CCNT2 ELL CCNT1 ELOA AFF4 ELOB CDC73 NELFB MLLT1 ELOC MLLT3 NELFCD SUPT6H NELFA IWS1 NELFE EAF1 SUPT16H EAF2 NCBP1 SKIC8 NCBP2 CTR9 CTDP1 RTF1 SUPT4H1 LEO1 PAF1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes KCNU1 CATSPER1 CATSPERB CATSPER3 CATSPERD CATSPER2 CATSPERG CATSPER4 HVCN1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle RHOT2 RAP1GDS1 TRAK1 MFN1 MFN2 MYO19 TRAK2 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 RAPGEF1 LAMA4 LAMA3 CRK LAMC2 LAMB1 PTK2 LAMC1 RAC1 HGF DOCK7 TNS4 SRC TNS3 MET ITGB1 RAP1B CRKL ITGA3 ITGA2 RAP1A GAB1 LAMA5 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation POM121C PHC2 NUP42 NUP62 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 PHC3 CETN2 NDC1 NUP210 NUP155 TRIM28 NUP153 NUP93 MDM2 NUP50 NUP35 NUP54 BMI1 RING1 RNF2 HNRNPK FOXL2 HIC1 L3MBTL2 SP3 CDKN2A VHL SUZ12 DAXX NUP107 SMC3 SATB2 NPM1 CDCA8 NFKB2 NUP160 NUP85 RAD21 SIN3A EIF2AK2 STAG1 CTBP1 STAG2 NRIP1 EP300 SEC13 PPARGC1A TFAP2B NCOA1 NUP133 TFAP2C NCOA2 CREBBP HDAC2 SMC1A RANGAP1 PARK7 PARP1 INCENP HDAC7 BIRC5 CHD3 IKBKG AURKB XPC PML AURKA NUP43 HERC2 RANBP2 DNMT3B DNMT3A DNMT1 RELA IKBKE SMC5 SMC6 NUP37 DDX17 NSMCE3 NSMCE2 MITF NSMCE1 NFKBIA MRTFA EID3 ZBED1 UBA2 SAE1 TOP2A TOP2B ZNF131 MTA1 SENP5 HDAC1 SENP2 SAFB PIAS4 SENP1 NSMCE4A HDAC4 PIAS3 TOP1 THRB SP100 UBE2I TOPORS UHRF2 VDR SATB1 CASP8AP2 NR1H2 RORA NOP58 NR3C1 RWDD3 NR2C1 MBD1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR CBX5 RXRA SUMO1 TP53BP1 SUMO3 SUMO2 RARA PGR RNF168 PPARG PPARA ING2 BRCA1 RAD52 TP53 NCOR2 XRCC4 ZNF350 MDC1 TDG BLM PCNA WRN PCGF2 DDX5 HIPK2 H4C9 HNRNPC RPA1 NUP205 POM121 NUP188 TRIM27 AAAS CBX8 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 FGF9 FGF20 FGF23 FGF16 SOS1 FGF18 PIK3R1 PIK3CA NRAS GAB1 FRS3 HRAS PLCG1 FRS2 FGF1 FGF2 PTPN11 FGF4 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling PTPN7 PTPN6 PTPN5 IL18R1 TBK1 PTPN2 PTPN4 CASP1 STAT3 PTPN18 IL37 PTPN20 PTPN12 PTPN23 SMAD3 PTPN13 PTPN14 PTPN11 IL18BP SIGIRR PTPN9 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK2B CAMKK1 CAMKK2 CALM1 CAMK4 CAMK2G KPNA2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease SKIC2 DIS3 HBS1L EXOSC7 NT5C3B EXOSC6 EXOSC5 SKIC3 EXOSC4 DCPS EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines EZH2 KMT2A ASH2L NSD2 KMT2C SUV39H2 SETD2 SETD3 PRDM9 NFKB2 SETD6 SUV39H1 DOT1L RELA SETD7 NSD3 MECOM H3C8 NSD1 KMT5B SMYD3 ATF7IP DPY30 SETDB1 KMT5C SETDB2 ASH1L KMT2D AEBP2 NFKB1 WDR5 H3C15 EED KMT2B PRDM16 SUZ12 EHMT2 EHMT1 SETD1B SETD1A SMYD2 H4C9 RBBP4 RBBP5 RBBP7 KMT5A DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine GOT2 FMO1 SUOX TST CTH ETHE1 SLC25A10 CDO1 GADL1 CSAD ADO TXN2 MPST TSTD1 SQOR METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway MTAP APIP MRI1 ADI1 ENOPH1 GOT1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress TXNRD2 SOD3 ATOX1 SOD1 CCS AMER1 CDKN2A ABCG2 STAT3 COX7B EGF HMOX2 BCL2 PDGFA AREG COX7C BCL2L1 COX8A COX8C COX5B COX5A VCP COX6C HDAC3 SMARCD3 CHD9 COX6A1 HBB COX6A2 GSK3B BACH1 HELZ2 G6PD COX6B2 TGS1 COX6B1 HMOX1 NCF1 NCF2 EP300 TBL1X NCF4 HIGD1C NCOA1 MED1 NCOA2 CREBBP NCOA6 HBA2 CYBB PRKAA2 NCOR1 CYBA TBL1XR1 CARM1 MAFK NFE2L2 CAT SOD2 MAP1LC3B FBXL17 PRDX2 PRDX1 SLC7A11 NOTCH1 RBX1 PTK6 FABP1 ALB P4HB IDH1 TALDO1 NCOR2 GSTA1 NOX4 MT-CO1 NLRP3 UFD1 TXNIP MT-CO2 MT-CO3 TKT CUL3 NPLOC4 CDKN1A PGD SQSTM1 SKP2 SP1 SIN3A GPX2 PSMD8 PSMD6 PSMD7 TXN2 PSMD2 PSMD3 SESN2 PSMD1 TXNRD1 BTRC KEAP1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CYCS TRIM21 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRKCI COX7A2L CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 COXFA4 COX7A2 ABCC1 COX7A1 RXRA PPARA BRCA1 PRKCD COX4I1 COX4I2 AKT2 MYC AKT3 AKT1 EIF2AK3 CSNK2A1 AQP8 CSNK2A2 NUDT2 CSNK2B ATF4 PRDX3 PRDX6 NOX5 UBXN7 GSTP1 NQO1 GSTA3 ERO1A SESN1 MUL1 DPP3 STAP2 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 GPX1 GPX3 GPX6 PALB2 GPX5 GPX8 TXN GPX7 ATP7A BLVRB BLVRA HM13 CCL2 ABCF2 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein MGAT1 PRKCSH CANX MOGS GANAB PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 PIK3R1 PIK3CA FGF10 GAB1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FGF7 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN RIT1 RIT2 NTRK1 BRAF NGF MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis NTN3 CDH4 BNIP2 CTNNA2 NEO1 SPAG9 MYOG MEF2B MYOD1 TCF12 MYF6 TCF4 CDH15 MYF5 CDH2 MEF2A CTNNB1 MEF2D CDON CTNNA1 MEF2C ABL1 TCF3 CDC42 MAPK14 MAPK12 MAP2K6 MAPK11 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation RPS6KA3 RPS6KA5 RPS6KA2 MAPKAPK2 RPS6KA1 ATF1 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 TGFA LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN FGF10 EGF AREG FGF2 FGF4 LAMA5 PRL FGF7 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 ITGA2B CBX6 PHC2 GATA3 PHC1 H2AX CBX4 GATA2 CBX2 GATA1 ASH2L SMARCB1 PHC3 LGALS3 CTLA4 BMI1 H3-3B SMARCC1 SMARCC2 H3C8 RING1 H2AJ SRC YAP1 RNF2 H3C15 CCND3 CCND2 CCND1 H2BC9 H2BC8 H2BC5 ABL1 H2BC3 SMARCA2 SMARCA4 CDK6 H2BC1 TP73 ACTL6B ACTL6A CTSV H2AB1 CTSL CTSK H2AC8 H2AC6 H2AC7 PBRM1 PRKCQ KMT2A KMT2C SERPINB13 GPAM SMARCD3 SIN3B ARID2 DPY30 SIN3A H2BC26 H2BC21 WDR5 CR1 EP300 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SMARCD1 CREBBP AUTS2 SMARCD2 IL2 H2BC11 IL3 TCF3 LDB1 PSMD8 RBBP5 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMARCE1 H2AZ2 PTPN11 PML TNRC6C PRKCB NFATC2 PSMA5 TNRC6A PSMA6 ITCH TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXP3 PSMD13 MYB BLK ZFPM1 ELF1 PSMA7 ELF2 CBFB PAX5 PSMB6 RUNX1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 PRMT6 RPS27A KMT2D ADRM1 SEM1 PRMT1 GP1BA PSMC5 PSMC6 PSMC3 KMT2B PSMC4 PSMC1 PSMC2 NFE2 HDAC1 SOCS3 LMO1 LMO2 TJP1 SETD1B OCLN LIFR SETD1A KCTD6 CCNH ESR1 SOCS4 NR4A3 RSPO3 CDK7 TCF12 AXIN1 MNAT1 KAT2B ARID1A ARID1B TAL1 H2AC19 H2AC14 IFNG H2BC12L THBS1 YAF2 CSNK2A1 CSNK2A2 CSNK2B TNFRSF18 SPI1 PCGF5 HIPK2 CLDN5 H4C9 RYBP MOV10 AGO3 PF4 AGO4 MYL9 H2AC20 AGO1 CSF2 AGO2 IL2RA CBX8 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization EZH2 H2AX CDH4 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B CLDN2 H3C8 MTBP ZC3H12A CSNK2A3 CLDN6 H2AJ CLDN4 CLDN3 SRC CLDN9 CTNND1 CLDN8 CLDN7 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 CLDN22 CLDN20 ZMYM2 CLDN23 RACK1 CLDN11 CLDN10 CLDN15 CLDN14 SUZ12 CLDN12 H2BC9 CLDN19 H2BC8 CLDN18 H2BC5 CLDN17 CLDN16 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST SDK1 H2AC8 SDK2 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 PARD6G PARD6B MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 PATJ F11R PALS1 ZEB1 CRB3 PARD6A PARD3 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 RBBP7 H2AZ2 TGIF2 TNRC6C DOCK1 TNRC6A TNRC6B ARHGEF4 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 VAV2 PRDM8 BHLHE22 KDM1A CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 CLDN5 SNAI1 ZNF217 FURIN PCSK6 ANK3 TYK2 RB1 POMT2 DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PRKCI PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CLDN1 RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 JAK2 H4C9 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex TAB3 TAB2 TAB1 UBA52 IRAK2 TICAM2 TICAM1 TLR4 LY96 UBB TRAF6 CD14 UBC RPS27A MAP3K7 INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling HLA-DRB3 HLA-DRB1 UBE2E1 JAK1 HLA-A B2M HLA-DPA1 CDK1 HLA-DQB2 HLA-DQB1 PSMB8 IFNB1 STAT1 STAT3 MAPK1 MAPK3 HLA-DPB1 PLCG1 IRF3 NPM1 IFITM3 IFITM1 IFITM2 IFIT5 IFI35 IFIT1 HLA-DRA IFI30 IFIT3 IFIT2 ICAM1 TRIM29 TRIM26 TRIM22 FAAP100 GBP5 GBP7 RSAD2 IFI27 TRIM17 PDE12 UBE2N TRIM14 ATF6 TRIM10 EGR1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 RNASEL IFI6 FAAP24 IRF1 FAAP20 PGGT1B FLNB HSPA1L IFI44L ILF2 MID1 IP6K2 MT2A VCAM1 FANCM FANCL FANCA HSPA2 FANCB FANCE FANCG PTPN11 FANCF ISG20 XAF1 FCGR1BP PTPN6 CIITA ADAR EIF2S3 OASL TRIM68 TRIM62 EIF2S2 OAS1 EIF2S1 OAS3 IRF8 IRF6 EIF4E2 IRF9 BECN1 SAMHD1 TRIM46 TRIM48 GBP3 SNCA TRIM45 MX2 MX1 TRIM35 TRIM38 CENPX TRIM31 TRIM34 ACTB IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 TRIM25 DUS2 IFNA21 IFNA14 GBP6 IFNA16 IFNA17 MAVS TP53 IFNA10 RIGI FLNA SPHK1 ACTG1 PIM1 NCK1 BST2 ILF3 FCGR1A ARIH1 NUP205 POM121 NUP188 FNTA FNTB AAAS POM121C NUP42 IFNAR1 NUP62 FURIN TPR CD44 NUP88 RAE1 KPNA1 NUP214 SFN NDC1 NUP210 NUP155 IFNGR1 IFNGR2 NUP153 NUP93 TYK2 NUP50 NUP35 NUP54 STAT2 EIF4E EIF4G1 FKBP5 HSPA1B NCAM1 KPNA7 KPNA4 KPNA5 NUP107 EIF4G3 KPNA2 HSPA8 EIF4G2 KPNA3 EIF4E3 PPP2R1B FANCC PPP2R1A NUP160 KPNB1 HLA-H HLA-C HLA-F NUP85 HLA-G HLA-E EIF2AK2 ISG15 SEC13 CASP1 NUP133 PPP2R5A IRF2 DNAJC3 OAS2 IKBKB GBP2 GBP4 IKBKG PML UBE2L6 PPP2CA CHUK HERC5 PPP2CB NUP43 GBP1 RANBP2 TRIM21 UBA52 ABCE1 HSPA1A HLA-B UBB UBC CENPS RPS27A NUP37 IRF5 EIF4A2 EIF4A1 SOCS3 HSPA5 EIF4A3 USP18 SP100 UBE2I PIAS1 PTAFR NEDD4 SUMO1 SMAD7 PTPN2 PRKCD YBX1 IRF4 PIN1 CAMK2B CAMK2D CAMK2A IFNG PPM1B EIF2AK3 CAMK2G UBA7 PRKRA TARBP2 SOCS1 JAK2 HLA-DQA2 HLA-DRB5 IRF7 HLA-DRB4 DHX9 RAF1 PTPN1 MAP2K6 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 TNPO1 ANAPC2 XPO1 ANKLE2 PTTG1 EMD LEMD3 RCC1 LMNB1 SPAST CC2D1B SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 TUBB6 TUBB3 TUBB1 TUBA4B PPP2R2A TUBA4A TUBA8 TUBA1C TUBA1B TUBA1A FBXO5 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 NUP62 BANF1 NDC1 NUP155 NUP93 NUP35 NUP54 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 KPNB1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 LBR KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 CHMP4A BIRC5 PSMD8 KIF2C CHMP6 KIF2B CHMP7 PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CHMP2B CLASP1 PSMA4 DYNC1I1 CHMP2A PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 RAN NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2I SUMO1 VPS4A TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs RAB7A TBC1D20 TSC2 TSC1 RAB5B MAP1LC3B RAB5C RAB11A RAB5A RAB6A OPTN RAB6B RAB8A RABGAP1 GABARAP GGA2 RABGEF1 GGA1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B ARF6 TBC1D2 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC PLA2G3 PLA2G4B PLA2G6 PLA2G2A PLB1 PLA2G4F TMEM86B PLA2G4E LPCAT4 PNPLA8 PLA2G10 PLA2G4C MBOAT2 PLAAT3 PLA2R1 LPCAT3 LPCAT2 PLBD1 PLA2G4A PLA2G1B LPCAT1 PLA2G5 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism PGK1 ENO1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity UACA MAPK1 APIP MAPK3 CYCS XIAP CASP9 AVEN DIABLO APAF1 CARD8 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling CASP8 FAS FASLG CASP10 FADD RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 GTF3C2 GTF3C3 CRCP GTF3C4 GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade SOS1 THEM4 IGF1R KLB IRS1 PDE3B AKT2 PIK3R4 IRS4 IRS2 IGF2 FGF1 IGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) LEUTX TPRXL DPPA4 EP300 TPRX2 DPPA2 ZSCAN4 DUXA DUXB TP53 CREBBP TEAD4 TUT7 KDM4E YAP1 TUT4 TPRX1 DUX4 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors HRH1 HRH3 HRH2 HRH4 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 FGFR3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 SEL1L PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 SYVN1 SHH ERLEC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA CNOT4 CNOT6 PARN CNOT7 TNKS1BP1 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B TUT7 PABPC1 TUT4 EIF4G1 EIF4A2 EIF4A1 PAIP1 PAN2 PAN3 CNOT10 EIF4A3 CNOT11 CNOT6L SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors APOB CD36 PRDX1 SAA1 S100A9 CD5L APOA1 SSC5D HMGB1 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition MCM6 MCM2 CCNB1 CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 CDKN1C RB1 CDKN2D CDKN1A CDKN2B CDKN1B CDKN2C CCND3 CDKN2A CCND2 CCND1 E2F1 E2F2 ABL1 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 CDC6 PPP2R1B PPP2R1A PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 MYBL2 PSMD1 SKP1 PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 RRM2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 MCM10 MAX PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PTK6 PSMC1 RPA4 TOP2A LIN54 PSMC2 CKS1B LIN52 LIN37 HDAC1 LIN9 CABLES1 WEE1 CDC7 CCNH PPP2R2A CDK7 MNAT1 POLE RBL2 RBL1 AKT2 MYC AKT3 AKT1 FBXO5 PCNA JAK2 DYRK1A LYN DHFR E2F4 TK1 TYMS E2F5 PPP2R3B E2F6 RPA1 RPA2 CDC45 POLE4 MCM7 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux TNRC6A TNRC6B RXRB NCOR2 HDAC3 GPS2 ABCG1 CETP EP300 KDM4A TBL1X NCOA1 KDM1A ABCA1 APOC4 NR1H3 APOE NCOR1 APOC2 NR1H2 TBL1XR1 APOC1 KDM3A KDM1B APOD ARL4C EEPD1 MOV10 AGO3 AGO4 RXRA AGO1 ABCG8 AGO2 ABCG5 TNRC6C GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding CXCL8 C5AR2 C5AR1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 C3 C5 ADRA1D ADRA1B ADRA1A TBXA2R OPN1MW CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P HRH1 HTR6 C3AR1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRB3 CYSLTR1 CYSLTR2 ADORA2B S1PR1 GABBR2 GABBR1 RHO SAA1 MCHR1 SST CCL2 SSTR3 OPN1SW CCR5 APP MC4R EDNRB EDN1 EDN3 GLP1R UCN VIPR1 MC3R VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP ADGRE2 POMC SHH GNGT2 MC1R ADGRE5 UCN3 UCN2 MC5R ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP ADCYAP1 SMO CRH IAPP ADCYAP1R1 CGA RAMP2 CALCA TSHB RAMP3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 CX3CR1 PTHLH CRHR1 GHRHR WNT6 GNG10 GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 CXCR4 WNT2 CD55 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 FZD4 CXCL12 WNT3A PTCH1 FZD7 GCGR WNT7B FZD6 PTCH2 FZD9 SCTR FZD8 WNT7A GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH MRGPRD GNB1 CMKLR1 PF4 GNAS PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 VIP GALR3 RAMP1 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 CCL19 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 ECE1 ECE2 ANXA1 PRLHR ADORA2A CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN TAS2R20 RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 KEL TAS2R40 TAS2R41 TAS2R42 TAS2R43 LHB TAS2R45 TAS2R46 NLN MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP ADRA2C TAS2R38 ADRA2B TAS2R39 ADRA2A TAS2R60 PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 TAS2R9 CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 GRM3 GRPR GRM2 EDNRA GRM4 PROK2 GRM7 PROK1 GRM6 UTS2R GPER1 NPFF GRM8 TRHR TAS2R1 UTS2B TAS2R3 AGTR1 TAS2R5 PTGFR TAS2R4 LPAR1 PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR TAS1R2 LPAR5 S1PR3 LPAR6 TAS1R1 NMS S1PR2 NMU S1PR5 GNRH2 TAS1R3 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY ACKR4 AVPR2 BRS3 ACKR3 GPRC6A OXT ACKR2 GPR132 AVP ACKR1 CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR OPRM1 CASR F2R LTB4R2 UTS2 NTS KNG1 MCHR2 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 OPRK1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 P2RY6 P2RY2 P2RY1 CCK HCRTR2 HCRTR1 KISS1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus MAPK8 UBA52 NGFR SQSTM1 UBB TRAF6 ITGB3BP PSENEN PSEN2 PSEN1 UBC NGF APH1A NCSTN RPS27A APH1B REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins EZH2 FURIN H2AX PCSK6 ANK3 MDM2 H3-3B H3C8 MTBP CSNK2A3 H2AJ SRC CTNND1 CDH1 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RB1 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 MAPK3 FOXQ1 H2AB1 TLE1 ZBTB33 POMT2 CTSL H2AC8 H2AC6 PKM H2AC7 DNM2 MYCN TMEM258 POMT1 SEC11A KLF9 MCRIP1 SEC11C FOXJ2 STRAP FOXP2 OST4 SP1 OSTC STT3A ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 SPCS3 H2BC13 SPCS2 H2BC14 SPCS1 H2BC15 DAD1 HDAC2 H2BC11 JUP SIRT1 TCF3 PSMD8 RBBP4 CANX PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 PSMD1 H2AZ2 KMT5A TGIF2 KLF4 TNRC6C PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 PSMA7 TWIST2 TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC ARHGAP32 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 KDM1A CTNNA1 H4C9 SNAI1 VCL MOV10 AGO3 AGO4 H2AC20 AGO1 ZNF217 AGO2 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane PDCD1 TMEM258 CD274 RPN2 DDOST RPN1 MAGT1 DAD1 OST4 JAK1 OSTC MIB2 STT3A STT3B PDCD1LG2 TUSC3 B3GNT3 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation GNA14 GNGT1 GNA15 OPRM1 POMC GNA11 GNAQ GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 PDYN GNB4 GNB3 GNB5 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation GUSB CD44 SPAM1 STAB2 CEMIP HYAL2 SLC9A1 SLC17A5 HMMR HEXB HEXA LYVE1 HYAL1 HYAL3 CHP1 HYAL4 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants FLT3 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis HS3ST6 HS3ST4 HS6ST2 HS3ST1 HS6ST3 HS3ST2 NDST2 NDST1 NDST4 NDST3 GLCE EXTL2 GPC1 HSPG2 GPC3 HS3ST3A1 GPC2 SDC4 SDC2 HS2ST1 GPC5 SDC3 GPC4 SLC35D2 EXTL3 GPC6 AGRN HS3ST3B1 EXT1 EXT2 SDC1 HS6ST1 HS3ST5 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms MAPK8 CYBA DVL1 DVL2 NOXO1 NOXA1 DVL3 WNT5A JUN FZD7 NOX1 RAC1 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 FGF9 FGF20 FGF23 FGF22 SOS1 FGF10 NRAS HRAS FGF1 FGF2 FGF3 FGF4 FGF6 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation SEC22B HLA-A B2M ITGB5 PSME1 PSME2 PSMB10 PSMB8 PSMB9 CTSV CTSL VAMP8 HLA-H HLA-C HLA-F LY96 HLA-G HLA-E HMGB1 NCF1 TLR1 NCF2 NCF4 CALR SNAP23 TLR6 TLR2 PDIA3 CYBB CYBA PSMD8 IKBKB TLR4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG CHUK FCGR1BP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 VAMP3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 HLA-B MYD88 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB CD14 PSMB2 PSMB3 UBC PSMB1 RPS27A LNPEP ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MRC1 TAP2 S100A9 TAP1 S100A8 CD207 SEC61A2 MRC2 SEC61A1 SEC61G SEC61B TAPBP STX4 BTK S100A1 CD36 ITGAV TIRAP CTSS FGB FGA FGG FCGR1A DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound KCNMB1 KCNMA1 CHRNA10 KCNN2 EZR SPTBN1 RDX MSN CLIC5 RIPOR2 SNAP25 CIB2 PJVK ESPN EPS8 SPTAN1 PLS1 TPRN TMC1 VAMP2 MYO7A STX1A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 PCLO USH1C CAPZB ESPNL BSN EPB41L3 SYP OTOG CABP2 CDH23 CACNA1D XIRP2 CABP1 EPS8L2 LRRC52 MPP1 OTOF GRXCR1 CASK SLC17A8 GRXCR2 GSN CAPZA1 WHRN CAPZA2 LHFPL5 OTOGL TMIE USH1G STRC EPB41L1 MYO15A SLC26A5 CACNA2D2 CHRNA9 SYN1 RAB3A TWF1 MYH9 CACNB2 ATP2B1 DNAJC5 MYO1C SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 TIMP2 TIMP1 RARA HELLS MYCN TGFB2 TNRC6A INHBA TNRC6B TGFBR1 KLF16 ACVR2A TGFBR2 TGFBR3 MMP14 MMP16 GIPC1 MYOG INHA MYOD1 TCF12 MYF6 TCF4 SP1 MYF5 PSENEN TGFB1 PSEN2 PSEN1 FGF2 APH1A NCSTN APH1B EP300 ARRB1 ARRB2 TCF3 MOV10 SMAD4 AGO3 SMAD3 AGO4 RXRA AGO1 AGO2 TNRC6C PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism KYAT1 ASRGL1 QDPR IL4I1 PAH PCBD1 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs PPP1CC FURIN SMAD7 TGFB2 FKBP1A TGFBR1 UBE2M TGFBR2 ITGAV TGFBR3 UBA52 STRAP STUB1 PPP1R15A USP15 LTBP4 LTBP2 LTBP3 MTMR4 LTBP1 UBB ITGB8 TGFB1 PMEPA1 UBC ITGB6 TGFB3 XPO1 RPS27A UCHL5 ITGB5 CBL BAMBI ITGA8 ITGB1 ITGB3 NEDD4L PPP1CB NEDD8 PPP1CA SMAD2 SMAD4 SMAD3 SMURF2 SMURF1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling USP8 AKT2 UBB AKT3 UBA52 ERBB2 UBC AKT1 RNF41 NRG1 NRG2 RPS27A CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly MTTP APOA2 APOC2 APOA4 APOB P4HB SAR1B APOA1 APOE APOC3 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression SAP30 H2AX SUDS3 DNMT3B DNMT1 SAP30L H3-3B TBP SAP18 H3C8 H2AJ H3C15 HDAC1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CCNH MBD2 H2AB1 POLR2E POLR2F H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AC19 H2AC14 H2BC12L SIN3B SMARCA5 SIN3A H2BC26 H2BC21 TTF1 SAP130 UBTF SAP30BP H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 BAZ2A POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 H2AZ2 ARID4B H2AC20 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation BMP1 LAMB3 TLL2 TLL1 LAMA3 LAMC2 COL7A1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants ALK DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant VWF ADAMTS13 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC4 GALNT1 ST3GAL1 ST6GALNAC2 ST3GAL2 ST3GAL3 ST6GAL1 ST3GAL4 ST6GALNAC3 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes CDKN1A TP53 ZNF385A PCBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress BAG5 POM121C HSPH1 NUP42 ATM NUP62 DNAJB6 NUP43 BAG3 TPR ATR HSF1 BAG1 NUP88 YWHAE RAE1 HSPA4 ST13 RPTOR NUP214 RANBP2 HSPA7 NDC1 HSPA6 NUP210 HSPA12A NUP155 HSPA12B NUP153 HSPA1A NUP93 NUP50 NUP35 NUP54 AKT1S1 NUP37 HSPA9 HSPA5 HSPA1B MAPK1 MAPK3 BAG2 NUP107 EEF1A1 HSPA8 MAPKAPK2 VCP CAMK2B CAMK2D CAMK2A NUP160 NUP85 GSK3B HSP90AB1 CAMK2G MLST8 EP300 SEC13 NUP133 CREBBP FKBP4 HSP90AA1 SIRT1 HSPA1L HDAC6 HSPB8 HIKESHI CCAR2 HSBP1 RPA1 DNAJC2 RPA2 DNAJC7 CRYAB RPS19BP1 PTGES3 HSPA2 NUP205 HSPA4L POM121 HSPA14 RPA3 NUP188 HSPA13 DNAJB1 MTOR AAAS BAG4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER SUMO2 GTF2H1 ERCC4 GTF2H2 ERCC1 ERCC5 CETN2 GTF2H3 UBA52 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RNF111 UBB UBC RPS27A UBE2V2 UBE2N RBX1 PIAS3 UBE2I PARP1 PARP2 USP45 RAD23A CHD1L CUL4A CCNH RPA1 DDB1 RPA2 RAD23B PIAS1 CUL4B XPA RPA3 DDB2 SUMO1 XPC SUMO3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death CASP8 TICAM2 TICAM1 TLR4 LY96 CD14 RIPK3 RIPK1 FADD PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors PRKACA PRKACG PFKFB1 PRKACB MLXIPL DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism UBE2L6 POM121C HERC5 NUP42 NUP62 NUP43 TPR NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 UBA52 NUP210 UBE2E1 EIF4E2 NUP155 BECN1 NUP153 NUP93 NUP50 JAK1 NUP35 NUP54 MX2 MX1 UBB EIF4E UBC RPS27A NUP37 EIF4G1 EIF4A2 EIF4A1 EIF4A3 USP18 STAT1 MAPK3 PLCG1 KPNA7 KPNA4 KPNA5 NEDD4 NUP107 EIF4G3 KPNA2 EIF4G2 EIF4E3 KPNA3 TRIM25 IRF3 RIGI PIN1 NUP160 IFIT1 KPNB1 NUP85 PPM1B EIF2AK2 ISG15 UBA7 UBE2N SEC13 NUP133 FLNB ARIH1 NUP205 POM121 NUP188 AAAS P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events MAPKAPK3 HRAS MAPKAPK2 RALGDS RALA RALB MAPK14 MAPK12 MAPK13 MAPK11 NRAS TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F2 F12 SERPING1 KLKB1 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation MGST1 MGST2 GGT3P GSTM1 GSTO1 GSTT2 GSTT1 OPLAH CNDP2 GSTA2 HPGDS ESD GSTA1 CHAC2 CHAC1 GSTT2B GSTM4 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT GSS GSTA5 GSTA4 GGT1 GSTM5 GSTK1 GSTP1 GGT5 GSTA3 GCLC GCLM AKR1A1 GGT7 GGT6 MGST3 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria ASL RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription H2AX MTA2 H3-3B TBP H3C8 H2AJ RRN3 ERCC6 H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 MAPK3 CCNH MBD2 H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 KAT2B MNAT1 KAT2A H2AC19 H2AC14 H2BC12L MBD3 H2BC26 H2BC21 TTF1 GATAD2B UBTF GATAD2A H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 EHMT2 POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A CAVIN1 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly ABCB7 CIAO3 NUBP1 NUBP2 RTEL1 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B BRIP1 POLD1 ERCC2 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions ERLIN2 FGFR1 BAG4 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGF9 FGF20 FGF23 FGF16 FGF18 FGFR3 FGF1 FGF2 FGF4 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNAI3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 GNAT3 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 ADCY9 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 IMP4 SNU13 RRP7A PDCD11 ERI1 GAR1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 CSNK1E RRP36 UTP6 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL MTREX RPP38 DIMT1 FTSJ3 EBNA1BP2 DKC1 NHP2 RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 NOP10 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 SENP3 UTP18 C1D DDX21 BMS1 RPP14 DCAF13 KRR1 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 XRN2 NCL NOP56 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 TRMT112 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A NOP2 NOP58 CSNK1D GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade PTPN6 PDPN PLCG2 MPIG6B FCER1G GP6 VAV3 SYK RAC1 VAV2 PRKCZ VAV1 RHOA PIK3CB PIK3CG PDPK1 RHOB CLEC1B PIK3R3 PIK3R2 RAC2 PIK3R1 PIK3CA PIK3R6 LCK PIK3R5 LYN CDC42 FYN RHOG LCP2 LAT PTPN11 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling TIMP1 CXCL1 CCR5 CXCL2 CSF3 IL1RN TNF IL12B IL12A IL10RB IL1R2 IL10RA CSF1 CCR1 LIF IL6 TYK2 TNFRSF1B JAK1 TNFRSF1A CXCL8 FCER2 CCL19 ICAM1 CCL22 CCL20 IL10 CCR2 PTGS2 CXCL10 IL18 IL1A IL1B STAT3 CCL5 CCL4 CCL3 CD86 CCL3L3 CD80 PTAFR FPR1 CSF2 CCL2 IL1R1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis LTF GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 NFE2L2 PSMD3 PSMD1 BTRC SKP1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation SERPINA1 SOD1 FN1 F5 F8 RAC1 VAV1 SRC SHC1 RAP1A MAPK1 MAPK3 EGF MAPK14 CLU SERPING1 TF DGKG DGKE DAGLA DGKD DGKB DGKA PRKCQ ABHD6 SOS1 ABHD12 CRK PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI RASGRP2 DGKH VEGFA HGF PRKCZ RHOA PIK3CB PIK3CG RHOB PDPK1 CLEC1B PIK3CA LCK APOA1 LAMP2 CDC42 PCDH7 FYN CSK RHOG PPIA RASGRP1 PTPN11 PTPN6 PDPN MPIG6B CALM1 FCER1G GP6 APP SERPINE1 GNA13 TBXA2R GNA12 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 CD109 TAGLN2 NHLRC2 STXBP3 TEX264 STXBP2 PDGFB ENDOD1 A1BG YWHAZ APOH VTI1B RAB27B MANF A2M CALU MAGED2 HRG RAC2 FERMT3 SERPINA3 ORM1 ECM1 GNGT1 OLA1 CTSW ORM2 SERPINA4 GNGT2 TMSB4X TIMP3 QSOX1 ALB AHSG ANXA5 RAPGEF3 RAPGEF4 TOR4A GNAT3 CD63 SPP2 LEFTY2 LY6G6F MGLL VEGFB VEGFC VEGFD LHFPL2 PCYOX1L PLCG2 MPL F13A1 POTEKP TUBA4A VAV3 CFL1 FAM3C ABCC4 APLP2 PTK2 SYK TMX3 GNAI3 SELENOP SCG3 THPO GP9 RARRES2 PFN1 GP1BB VAV2 CYRIB FLNA SELP GP5 SCCPDH ACTN2 GNAQ LGALS3BP GNG10 WDR1 PLEK GNG3 GNAI1 PHACTR2 CYB5R1 SRGN GNG2 GNAI2 MMRN1 PECAM1 GNG5 CAP1 ITIH4 GNG4 IGF2 ITIH3 GNG7 IGF1 PLG GNG8 TTN CLEC3B CDC37L1 AAMP BCAR1 ACTN1 GNA14 GNA15 GNA11 GNG12 GNG11 GNG13 GNB2 GNB1 PF4 GNB4 GNB3 GNB5 ITGA2B ALDOA P2RY12 PSAP CD9 PRKCG PPBP ADRA2C ADRA2B ADRA2A TGFB1 PRKCB GP1BA APOOL PROS1 HSPA5 GAS6 STX4 F2 TIMP1 TGFB2 BRPF3 CD36 F2RL2 F2RL3 PRKCD PRKCA PLA2G4A F2R ITPR1 ITPR2 KNG1 ITPR3 THBS1 AKT1 TGFB3 CFD ITGB3 PIK3R3 ARRB1 PIK3R2 PIK3R1 ARRB2 RAP1B PIK3R6 PIK3R5 FGB TRPC7 FGA LYN TRPC6 VWF P2RY1 TRPC3 FGG APBB1IP RAF1 TLN1 PTPN1 VCL LCP2 LAT GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis B3GALT6 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN GPC6 DCN BCAN VCAN AGRN CSPG5 CSPG4 PXYLP1 SDC1 B4GALT7 UXS1 XYLT2 B3GAT3 XYLT1 FAM20B B3GAT2 B3GAT1 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases TFPT MCRS1 INO80 PSMA5 PSMA6 TGFBR1 PSMA3 TGFBR2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 OGT PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEDD8 ACTB ACTL6A H2AC8 H2AC6 H2AC7 SMAD7 H2AC17 H2AC12 H2AC1 USP15 H2AC19 H2AC25 H2AC14 H2AC21 TGFB1 UCHL5 BAP1 UCHL1 SENP8 UCHL3 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 RUVBL1 NFRKB ACTR5 BARD1 KDM1B PSMD8 ACTR8 YY1 PSMD6 PSMD7 INO80C PSMD2 INO80B PSMD3 INO80E PSMD1 INO80D H2AC20 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors GRIK1 GRIK2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions PAOX MAOA MAOB SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants SOS1 EREG PIK3R1 BTC PIK3CA SHC1 NRG2 HBEGF NRG3 EGFR NRG4 NRAS HSP90AA1 GAB1 CDC37 HRAS ERBIN PLCG1 EGF ERBB2 NRG1 CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA PTPN6 BTLA TNFRSF14 PTPN11 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly H2AC6 H2AC7 H2AX H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ADNP2 H2BC9 ADNP H2BC8 H2BC5 H2BC11 H2BC3 CBX1 H2BC1 H4C9 CHD4 H2AB1 H2AZ2 H2AC20 CBX3 H2AC8 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle CPD PKP4 PLEKHG5 EPHA2 RASAL2 MUC13 TFRC VANGL1 FLOT2 PIK3R2 PIK3R1 GRB7 DSP TXNL1 STMN2 ARHGAP5 KIF14 ARHGAP35 RND1 STIP1 FRS3 EPSTI1 WDR6 PLXNA1 FAM83B RBMX ANKRD26 DST KIDINS220 CAV1 RRAS2 FRS2 ALDH3A2 TMEM59 PTPN13 CCDC88A LEMD3 FAM135A VANGL2 DEPDC1B UBXN11 DLG5 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling CAP2 ROBO1 ABL2 CLASP1 CLASP2 CAP1 ABL1 SLIT2 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants PDGFRA TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding NECAP1 CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 CHMP2A APP SNX2 BLOC1S3 SNX5 NAPA TBC1D8B SNAPIN AP1G1 SORT1 DTNBP1 AP1S2 PUM1 AP1B1 TPD52L1 AP1S1 GOLGB1 AP1S3 YIPF6 TGOLN2 ACBD3 TFRC AP1M2 AP1M1 FTH1 IGF2R HGS CLINT1 SH3GL2 FTL VAMP2 ARF1 STX4 CTSZ AP4E1 CLTB AP4M1 AP1G2 BLOC1S1 CLVS2 AP4S1 CLVS1 AP3B1 TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 RAB5C GBF1 GNS SNX9 SNAP23 ARRB1 CLTC PICALM CLTA PIK3C2A OCRL GAK HIP1R CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins CASP3 CASP8 CASP7 VIM DBNL GAS2 MAPT ADD1 SPTAN1 PLEC CASP6 GSN LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis NRIP1 RXRB RXRA NR1H3 PCK1 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) DNAJB11 EIF2S3 DIS3 PARN EIF2S2 CREB3L3 EXOSC7 SULT1A3 EIF2S1 EXOSC6 EXOSC5 EXTL2 EXOSC4 EXOSC9 KHSRP IGFBP1 EXOSC8 PREB EXOSC3 EXOSC2 CXCL8 EXOSC1 EXTL3 GOSR2 ADD1 FKBP14 HERPUD1 MYDGF TATDN2 SERP1 CEBPB SEC31A CREB3L4 GFPT1 CREB3L1 CREB3L2 TSPYL2 DDX11 WIPI1 PDIA6 PDIA5 ATP6V0D1 ERN1 CREB3 DCSTAMP CTDSP2 KDELR3 ATF6B SHC1 HSPA5 DCTN1 CEBPG CXXC1 EXTL1 SSR1 DNAJB9 ZBTB17 KLHDC3 WFS1 EDEM1 ASNS YIF1A CREBRF SRPRA ACADVL SRPRB TPP1 HDGF GSK3A PLA2G4B LMNA MBTPS1 NFYA HYOU1 NFYB NFYC MBTPS2 EIF2AK3 HSP90B1 DCP2 CUL7 ATF4 ATF6 ATF3 CALR PPP2R5B SYVN1 ARFGAP1 DNAJC3 DDIT3 TLN1 CCL2 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production DPEP2 DPEP1 GGT5 CYSLTR1 CYSLTR2 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 CDC25B PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 MAX PSMC5 PSMC6 PSMC3 PSMC4 RB1 PTK6 PSMC1 LIN54 CDKN1A PSMC2 CDKN1B CKS1B LIN52 LIN37 FZR1 LIN9 CCND1 CABLES1 E2F1 WEE1 SKP2 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 CDK7 MNAT1 RBL2 AKT2 MYC AKT3 AKT1 E2F4 E2F5 PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters SLC35C1 POM121C NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 SLC17A5 NUP35 NUP54 SLC40A1 HEPH SLC35A1 DERL3 DERL1 DERL2 SLC11A2 OS9 SLC26A2 SLC34A3 SLC34A2 SLC34A1 NUP107 GCKR CP ABCA12 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 ABCB6 VCP ABCB4 SLC5A2 SLCO1B1 SEL1L SLCO1B3 SLC33A1 SLC6A5 SLC9A6 SLC26A4 SLC26A3 ABCD4 SLC9A9 SLC6A2 SLC12A3 GCK SLC22A12 SLC2A1 SLC2A10 ABCC6 SLC12A1 SLC12A6 NUP160 LMBRD1 SLC29A3 HK1 SLC24A4 RNF185 SLC20A2 ABCB11 NUP85 SLC35A2 SLC16A1 SLC24A5 ABCC8 SEC13 NUP133 ABCC2 APOA1 RNF5 ERLEC1 PSMD8 CFTR PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 NUP43 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 RANBP2 UBA52 PSMD12 PSMD11 SLC22A5 PSMD14 PSMD13 SLC35A3 SLC1A1 SLC2A9 PSMA7 SLC24A1 SLC3A1 PSMB6 SLC1A3 SLC2A2 PSMB7 SLC5A1 PSMB4 SLC3A2 PSMB5 UBB SLC6A3 PSMB2 PSMB3 SLC5A7 SLC6A20 UBC PSMB1 ABCD1 RPS27A NUP37 ADRM1 SEM1 SLC67A1 PSMC5 PSMC6 PSMC3 PSMC4 AVPR1B PSMC1 SLC6A19 AVPR2 PSMC2 SLC36A2 AVP AVPR1A SLC6A14 ABCA1 SLC7A7 SLC7A9 SLC5A5 SLC17A8 ABCG8 ABCG5 ABCC9 ABCA3 SLC4A1 RHAG KCNJ11 ERLIN1 ERLIN2 NUP205 POM121 NUP188 AAAS U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing DDX42 DDX23 NCBP1 NCBP2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 TXNL4A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G SRSF2 POLR2H POLR2I POLR2J POLR2K SRSF6 POLR2L SRSF7 GTF2F1 GTF2F2 SRSF1 SNRNP40 YBX1 SNRPD2 SNRPD1 SNRPD3 SNRPG ZCRB1 SNRPE SNRNP200 PDCD7 SNRPF SNRNP35 SNRNP25 SNRPB RNPC3 ZMAT5 ZRSR2 SNRNP48 EFTUD2 PRPF6 PRPF8 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins DEFB108C DEFB130A DEFB130B DEFB4B CCR6 CCR2 DEFB103B TLR1 DEFB105B DEFB129 DEFB128 DEFB131A TLR2 DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis DOLK PMM2 DHDDS MPI DPM1 DPM2 DPM3 GALE GNE GALM GALK1 GALT NUS1 PGM1 SRD5A3 GFPT1 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 HSP90AA1 CDC37 ERBIN ERBB2 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage ALKBH2 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs FLT3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle PPFIA3 PPFIA2 SNAP25 SYT1 UNC13B VAMP2 CPLX1 STX1A SLC22A2 TSPOAP1 SLC22A1 SLC18A2 MAOA RAB3A RIMS1 PPFIA1 PPFIA4 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG5 B3GALT6 CSPG4 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN DCN GPC6 BCAN VCAN AGRN HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM7A PHF2 KDM5C KDM5B KDM3B KDM5D PHF8 UTY KDM2A KDM2B KDM4D ARID5B JMJD6 KDM6B H3C8 KDM4C H3C15 KDM4A KDM1A KDM5A RIOX2 KDM6A KDM3A H4C9 KDM1B KDM4B ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions LYN GBF1 NCL FURIN CLINT1 KDELR1 TSG101 YBX1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling ARHGEF12 MYH9 RHOB RHOC MET MYL12B MYH11 RAC1 SEMA4D ARHGAP35 LIMK2 RND1 LIMK1 RRAS MYH14 MYH10 PLXNB1 MYL6 RHOA ERBB2 ROCK1 MYL9 ROCK2 ARHGEF11 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e DPM1 DPM2 DPM3 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates RRM2 NME2 NME1 GUK1 DTYMK AK1 AK2 AK4 GLRX AK5 AK6 AK7 AK8 AK9 NUDT13 RRM1 NME3 CTPS2 NME4 CTPS1 DCTD RRM2B NME6 CMPK1 DCTPP1 TYMS TXN TXNRD1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs RAD23A VCP RAD23B UBB PRKN ATXN3L UBA52 ATXN3 JOSD2 UBC JOSD1 RPS27A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis MOGAT3 MOGAT2 MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 GPAM LPIN1 LPIN2 LPIN3 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III TUBA4B TUBA4A CHMP2B CHMP2A TUBA8 TUBA1C TUBA1B SPAST TUBA1A CC2D1B TUBB8 IST1 LEMD2 TUBB8B TUBB2B TUBB2A TUBAL3 TUBA3E VPS4A TUBA3D TUBA3C CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 TUBB6 CHMP7 TUBB3 TUBB1 TUBB4B TUBB4A SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 TASL DUSP7 IRF5 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 SLC15A4 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR8 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MKKS MCHR1 TCP1 SSTR3 CCT8 BBS10 BBS9 CCT5 BBS2 CCT4 BBS1 TTC8 BBS12 BBS7 RAB3IP BBIP1 CCT3 LZTFL1 BBS5 CCT2 BBS4 SMO PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation NTRK1 IRS1 PIK3R2 IRS2 RHOA PIK3CA PIK3R1 PIK3CB NGF SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 ITCH HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 CNTN1 HEYL NOTCH1 RBX1 HDAC1 HEY1 DNER TLE4 TLE2 HDAC4 NUMB DTX1 HEY2 DTX2 DLK1 MIB2 SNW1 TLE1 JAG2 JAG1 CDK8 ADAM10 DTX4 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NBEA NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ ARRB1 HDAC5 ARRB2 HDAC2 HIF1A CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway CHUK TNF TNFRSF1A RBCK1 USP2 OPTN TRADD TAB3 TAB2 TAB1 RACK1 TRAF2 RNF31 TNFAIP3 SPATA2 OTUD7B IKBKB SHARPIN USP21 BIRC2 USP4 BIRC3 TRAF1 XIAP CYLD OTUD1 RIPK1 IKBKG MAP3K7 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion CHMP2B CHMP2A UBA52 UBB UBC RPS27A NEDD4L PDCD6IP TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C CHMP4C VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A CHMP6 UBAP1 CHMP7 VPS28 CHMP5 PPIA NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer PTPN6 GZMB RPS6 NPM1 IL10RA CCNB1 IRF4 DNMT1 CUL1 TWIST1 JUNB BCL2A1 CEBPB STAT5A RBX1 RB1 HDAC1 MAPK1 STAT3 MAPK3 MOV10 ZAP70 AGO3 AGO4 PRF1 FOXM1 AGO1 ICOS AGO2 SKP1 ZC3HC1 TNRC6C PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5C AGXT2 NT5C1A DPYS DPYD NT5M UPP2 NT5E UPP1 UPB1 TYMP THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor GNA14 GNGT1 GNA13 GNA15 TBXA2R GNA11 GNAQ GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 AAMP PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression EIF2S3 DIS3 PARN EIF2S2 EXOSC7 EIF2S1 EXOSC6 NFYA EXOSC5 NFYB EXOSC4 NFYC EXOSC9 KHSRP IGFBP1 EXOSC8 EXOSC3 EXOSC2 CXCL8 EXOSC1 HERPUD1 EIF2AK3 CEBPB DCP2 ATF4 ATF6 ATF3 HSPA5 CEBPG ASNS DDIT3 CCL2 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway ADH1A ALDH1A1 CRABP1 AKR1C3 DHRS3 ALDH1A3 CYP26A1 SDR16C5 CYP26B1 CYP26C1 DHRS9 RDH11 ALDH1A2 RDH10 RDH16 RDH5 RDH14 RDH13 DHRS4 ALDH8A1 ADH4 ADH1C SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling HRAS SOS1 EREG BTC SHC1 NRG1 NRG2 HBEGF NRG3 NRG4 NRAS ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport ABCG2 SLC22A3 ABCB1 SLC22A2 SLC22A1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest ARID3A CDKN1A CDKN1B TP53 ZNF385A PCBP4 E2F1 CCNE2 E2F7 E2F8 CCNE1 CDK2 CCNA2 CCNA1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes CACNA1H CACNB1 CACNB2 CACNB3 ITGB1 ITGB3 PIEZO1 ITGAV ITGA5 CACNA2D1 HSPG2 GJA1 SPP1 P2RX7 AKT1 PANX1 CACNG7 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis CD3G PLD4 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 PLD2 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 PRKCE IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 PLD1 IGKV5-2 IGKV1-5 IGLC6 AHCYL1 PLA2G6 PLCG2 SYK PRKCD ITPR1 ITPR2 ITPR3 IGHG3 IGHG4 IGHG1 IGHG2 PLPP5 PLPP4 PLD3 PIK3R2 PIK3R1 FCGR3A FCGR1A FCGR2A LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex IRAK2 TAB3 TAB2 TAB1 UBB TRAF6 UBA52 UBC RPS27A MAP3K7 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R1A BANF1 PPP2R2A ANKLE2 CCNB1 LMNB1 KPNB1 CDK1 CCNB2 EMD SIRT2 LEMD3 LBR VRK1 LEMD2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins YWHAE SFN TP53 BCL2L11 PPP1R13B TP53BP2 BID AKT2 YWHAH AKT3 BAD AKT1 YWHAG MAPK8 PPP3CC YWHAZ BMF BBC3 TP63 YWHAB E2F1 DYNLL1 DYNLL2 TFDP1 TFDP2 TP73 PMAIP1 BCL2 YWHAQ PPP3R1 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants FLT3 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN GRIN2B SRC NTRK2 RAC1 DOCK3 BDNF G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma GNG10 GNG3 GNG2 GNG5 AKT2 GNG4 GNG7 AKT3 RHOA GNG8 AKT1 PIK3CG PDPK1 PIK3R6 PIK3R5 GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling SOD1 MTAP IL12B IL12A SOD2 LMNB1 TYK2 JAK1 MSN PSME2 HNRNPF HSPA9 RALA PAK2 STAT1 STAT3 ARF1 P4HB IL6ST CAPZA1 VAMP7 SNRPA1 CFL1 ANXA2 GSTO1 TALDO1 GSTA2 IFNG CA1 IL10 TCP1 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF RPLP0 LCP1 RAP1B JAK2 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 CDC42 PDCD4 CRLF1 CANX HNRNPA2B1 PPIA DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 GALK1 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy UBE2N ARL13B HSF1 VCP UBE2V1 DYNC1I1 DYNC1LI1 DYNC1LI2 UBA52 DYNC1H1 DYNLL1 PCNT CETN1 HSP90AA1 PARK7 DYNLL2 HDAC6 CFTR UBB PRKN DYNC1I2 UBC IFT88 RPS27A FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation FGF22 TGFBR3 GIPC1 FGF1 FGF2 FGF10 FGF3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling PTPN6 SOS1 IL2RG INPPL1 JAK3 INPP5D JAK1 PIK3CD PIK3CB GAB2 PIK3R3 PIK3R2 PIK3R1 PIK3CA SHC1 JAK2 IL2 IL3 IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CSF2 IL2RA VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism SLC2A1 GSTO2 GSTO1 SLC2A3 SLC23A2 CYB5A CYB5R3 SLC23A1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT GALNTL5 B3GNT3 GALNTL6 ST6GALNAC2 GALNT12 ST3GAL4 ST3GAL1 GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 C1GALT1C1 ST6GALNAC3 MUC12 ST6GALNAC4 MUC13 MUC15 MUCL1 MUC3A MUC5AC MUC3B B4GALT6 MUC1 B4GALT5 MUC2 MUC7 MUC4 MUC6 GALNT3 MUC16 MUC17 C1GALT1 MUC19 MUC5B B3GNT7 MUC20 B3GNT4 MUC21 B3GNT2 GALNT11 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport SLC8B1 PARL AKAP1 AFG3L2 PHB1 SLC8A3 SMDT1 VDAC3 VDAC2 YME1L1 PMPCB PMPCA MICU3 VDAC1 MICU2 MICU1 MCU LETM1 STOML2 MCUB SPG7 PHB2 MAIP1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane MTMR2 SACM1L PI4KA SBF1 PI4K2B ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein BID BAK1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors HSP90AA1 HSPH1 CALR APOB SCARF1 HYOU1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC4 GALNT1 ST3GAL1 ST6GALNAC2 ST3GAL2 ST3GAL3 ST6GAL1 ST3GAL4 ST6GALNAC3 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins FURIN EEF2 CALM1 HSP90AB1 STX1B SNAP25 SYT2 SV2C SYT1 SV2B SV2A PDCD6IP GUCY2C VAMP1 VAMP2 STX1A HBEGF HSP90AA1 MAP2K4 CD9 MAP2K1 MAP2K2 NHERF4 TXNRD1 MAP2K7 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels STIM1 TRPC7 ORAI2 ORAI1 TRPC6 TRPC3 ITPR1 P2RX6 ITPR2 P2RX5 P2RX7 P2RX3 ITPR3 P2RX4 P2RX2 P2RX1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB NDRG1 RABGGTA TP53I3 BCL6 PERP TP63 TP53 PPP1R13B BIRC5 TP53BP2 TP73 BCL2L14 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling ALOX5 IL18R1 IL37 IL4 IL18RAP IL18 IL13 IL18BP CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily H2AX MTA2 H3-3B H3C8 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 CHD5 H2BC3 IKZF1 UBE2I IKZF2 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 SUMO1 CBX3 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 G6PC1 H2AC19 H2AC14 H2BC12L NR2C2 MBD3 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 FBP1 H2BC15 ADNP2 HDAC2 ADNP H2BC11 CBX1 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2AX MTA2 ZNF610 ZNF324 ZNF680 TRIM28 ZNF320 ZNF264 H3-3B H3C8 ZNF317 ZNF30 H2AJ ZNF257 H3C15 ZNF708 ZNF354A MTA1 HDAC1 MTA3 H2BC9 ZNF141 H2BC8 H2BC5 ZNF382 ZNF547 H2BC3 UBE2I H2BC1 ZNF669 ZNF136 ZNF425 H2AB1 CBX5 H2AC8 SUMO2 H2AC6 ZNF765 H2AC7 ZNF93 ZNF816 ZNF534 ZNF418 ZNF778 H2AC19 H2AC14 H2BC12L ZNF224 ZNF649 ATF7IP MBD3 SETDB1 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 ZNF519 H2BC12 H2BC13 H2BC14 H2BC15 HDAC2 H2BC11 ZNF454 H4C9 ZNF33A CHD4 RBBP4 CHD3 RBBP7 H2AZ2 ZNF331 H2AC20 ZNF28 ZNF273 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling SOCS2 RAG2 RAG1 TSLP IL7 BRWD1 IL2RG CRLF2 JAK3 JAK1 H3C8 IRS1 HGF IRS2 STAT5A H3C15 STAT5B PIK3R3 PIK3R2 IL7R PIK3R1 SOCS1 STAT3 SMARCA4 CISH KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development GATA3 JAG1 DLL1 LFNG HNF1B FOXC2 FOXC1 SIX1 PCDH19 HOXD11 SLIT2 HOXC11 WFDC2 HOXA11 PLAC8 SALL1 MECOM SIX2 ROBO2 WNT11 HOXA6 IRX1 IRX2 EMX2 OSR1 FGF2 GFRA1 NPNT POU3F3 PAX2 WNT4 BMP4 ITGA8 GREM1 GDNF CTNNB1 PAX8 LHX1 EYA1 ID4 ITGB1 HOXB4 WT1 WNT9B RET HNF4A Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4G1 DIS3L2 EIF4A2 EIF4A1 EIF4E EIF4B PAIP1 TUT7 PABPC1 PABPN1 TUT4 EIF4A3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 PHYH SLC25A17 PECR SLC27A2 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency OTC DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling PRKAR2B CALM1 PRKACA PDE1C PRKCE PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ITPR1 ADCY5 ITPR2 ITPR3 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 PLCG1 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR FDX1 FDXR FDX2 CYP11A1 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation PTK6 PTPN1 SRMS GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism CHST5 CD44 SPAM1 CHST2 CHST3 PAPSS2 PAPSS1 EXTL2 GPC1 HAS1 HAS3 GPC3 SLC17A5 IDUA GPC2 HEXB HAS2 NCAN GPC5 HEXA GPC4 BGN EXTL3 DCN GPC6 GLB1L3 GLB1L2 BCAN LYVE1 VCAN B3GNT3 FMOD GLB1L AGRN CHPF GLB1 NAGLU HYAL1 CHP1 HYAL3 SLC26A11 HYAL4 CSPG5 IDS CSGALNACT1 CSPG4 GUSB CSGALNACT2 ARSB KERA SLC26A2 CEMIP SLC26A1 HMMR DSEL CTSL B3GALT6 UST OGN HPSE B4GALT2 B4GALT3 B4GALT1 SLC9A1 SGSH HS2ST1 DSE HS3ST3B1 CHPF2 PXYLP1 B4GALT6 B4GALT7 B4GALT4 B4GALT5 PRELP ACAN CHSY1 CHSY3 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 GALNS SLC35B3 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 HS6ST1 ST3GAL4 HS6ST2 HS6ST3 ST3GAL1 NDST2 ST3GAL2 NDST1 ST3GAL3 NDST4 NDST3 GLCE OMD ABCC5 HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 SLC35D2 GNS CHST11 CHST12 CHST15 CHST13 ST3GAL6 CHST14 EXT1 EXT2 B4GAT1 SDC1 STAB2 HYAL2 CHST6 CHST7 B3GNT7 B3GNT4 FAM20B CHST1 B3GNT2 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders HDAC3 NCOR1 TBL1XR1 TBL1X CALM1 PRKACA HDAC1 SIN3A CAMK4 GPS2 NCOR2 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol DCAF13 KRR1 RPS2 FCF1 THUMPD1 PWP2 RPS14 RRP9 IMP3 WDR75 IMP4 NOP2 SNU13 NOP58 RRP7A PDCD11 GAR1 DHX37 PNO1 TBL3 MPHOSPH10 NOL11 NAT10 WDR46 WDR43 RPS9 UTP14A UTP14C RPS7 WDR36 RPS6 TSR3 HEATR1 NOC4L TRMT112 NOL6 RRP36 UTP6 UTP4 UTP3 FBL DIMT1 DKC1 NHP2 UTP25 EMG1 UTP20 NOP14 RCL1 NOP10 DDX49 DDX47 WDR3 BUD23 NOP56 UTP15 UTP11 DDX52 UTP18 BMS1 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane PRKAG1 CALM1 PRKAG2 YWHAE SFN PRKAG3 RAC1 YWHAH STXBP3 LNPEP RAB8A YWHAZ EXOC8 EXOC7 RALA VAMP2 YWHAB RAB4A STX4 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 MYO5A KIFAP3 RAB11A AKT2 AKT1 PRKAB2 PRKAB1 YWHAG MYH9 SNAP23 KIF3B KIF3A C2CD5 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 PRKAA2 ASPSCR1 RAB10 RAB14 RAB13 YWHAQ MYO1C TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression RARA HELLS MYCN TNRC6A TNRC6B KLF16 TGFBR3 MYOG MYOD1 TCF12 MYF6 TCF4 SP1 MYF5 EP300 TCF3 MOV10 SMAD4 AGO3 SMAD3 AGO4 RXRA AGO1 AGO2 TNRC6C GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism GALT GALE AKR1B1 GALM PGM1 GALK1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG MTRR MTR PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport BSG SLC16A7 SLC16A8 EMB SLC16A3 SLC16A1 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL NODAL DAND5 ACVR2A LEFTY1 ACVR1C CRIPTO3 CRIPTO ACVR1B LEFTY2 ACVR2B CFC1 CER1 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes PITPNB LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy PRKAA2 PRKAB1 PRKAG1 PLIN2 PRKAG2 PLIN3 PRKAG3 PRKAB2 HSPA8 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation HGS RAB7A KPNA1 UBA52 ATP6V1H RAB5A KPNB1 VPS33B NOS2 CORO1A UBB UBC RPS27A POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation STAT3 DPPA4 ZIC3 SALL1 SALL4 NANOG EPHA1 POU5F1 SOX2 FOXD3 CRIPTO FGF2 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation CD4 AP2B1 ATP6V1H ARF1 AP2A1 AP2S1 AP2A2 LCK AP2M1 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) H2AX ANAPC15 ANAPC16 ANAPC7 JUN UBE2C UBA52 UBE2E1 UBE2D1 ANAPC10 ANAPC11 IL6 CDC23 UBE2S CXCL8 CDC26 CDC27 H3-3B RELA CDC16 RPS6KA1 VENTX H3C8 ANAPC4 FOS ANAPC5 ANAPC1 ANAPC2 UBB H2AJ CCNA2 CCNA1 UBC RPS27A CEBPB NFKB1 H3C15 MAPK7 CDKN2D CDKN1A CDKN2B CDKN1B CDKN2C CDKN2A FZR1 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 STAT3 H2BC1 CDK6 MAPK3 CDK4 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 EHMT2 EHMT1 IL1A H2BC11 RPS6KA3 RPS6KA2 H4C9 H2AZ2 IGFBP7 H2AC20 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations POMT1 MGAT5B DAG1 POMGNT1 POMT2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle PPFIA3 PPFIA2 SNAP25 SYT1 UNC13B VAMP2 CPLX1 STX1A TSPOAP1 SLC18A2 SYN3 SYN2 SYN1 RAB3A RIMS1 PPFIA1 PPFIA4 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER TFPT MCRS1 INO80 COPS3 COPS6 CETN2 COPS8 UBA52 COPS5 UBB UBC RPS27A GPS1 RBX1 COPS4 RUVBL1 COPS2 NFRKB PARP1 PARP2 ACTR5 ACTB RAD23A CUL4A ACTR8 DDB1 YY1 RAD23B INO80C INO80B ACTL6A CUL4B INO80E INO80D COPS7B DDB2 COPS7A XPC RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs H2AX RHOC YWHAE PPP1R12A SFN PPP1R12B CDC25C PPP1R14A RAC1 H3-3B MYH14 MYH10 H3C8 YWHAH H2AJ KLK3 KLK2 KDM4C YWHAZ H3C15 PAK1 MYL12B PPP1CB MYH11 H2BC9 YWHAB H2BC8 H2BC5 H2BC3 H2BC1 MYL6 H2AB1 AR H2AC8 H2AC6 H2AC7 H2AC19 H2AC14 H2BC12L RHOA H2BC26 H2BC21 YWHAG MYH9 PDPK1 RHOB H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 PKN3 NCOA2 KDM1A H2BC11 H4C9 YWHAQ PKN2 H2AZ2 PKN1 MYL9 H2AC20 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA DBT BCKDHB DLD REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response BAG5 POM121C HSPH1 NUP42 ATM NUP62 DNAJB6 NUP43 BAG3 TPR ATR HSF1 BAG1 NUP88 YWHAE RAE1 HSPA4 ST13 NUP214 RANBP2 HSPA7 NDC1 HSPA6 NUP210 HSPA12A NUP155 HSPA12B NUP153 HSPA1A NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA5 HSPA1B MAPK1 MAPK3 BAG2 NUP107 HSPA8 MAPKAPK2 NUP160 NUP85 GSK3B SEC13 NUP133 SIRT1 HSPA1L HIKESHI CCAR2 RPA1 DNAJC2 RPA2 DNAJC7 RPS19BP1 HSPA2 NUP205 HSPA4L POM121 HSPA14 RPA3 NUP188 HSPA13 DNAJB1 AAAS BAG4 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling IL32 CD4 SNAP25 SDC1 CSF1R CSF3 IL10RB VAMP2 IL34 STX1A IL16 CSF1 IFNLR1 TYK2 IFNL1 TXLNA CASP3 JAK1 PTPRZ1 PRTN3 STX4 STX3 CSF3R STXBP2 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events POM121C NUP42 NUP62 NUP43 H2BC18 TPR NUP88 CHMP2B RAE1 CHMP2A NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 H3C8 NUP37 HNRNPK H3C15 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 NUP107 H2AC8 H2AC6 H2AC7 CEBPD H2AC17 H2AC12 H2AC1 NUP160 H2AC19 H2AC25 H2AC14 H2AC21 NUP85 H2BC26 CHMP1A H2BC21 H2BC17 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 TSG101 VPS4A MVB12B H2BC11 MVB12A VPS36 VPS37C CHMP4C VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A H4C9 CHMP6 SNF8 CHMP7 UBAP1 VPS25 VPS28 NUP205 POM121 H2AC20 NUP188 AAAS HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism HAL AOC1 CARNMT1 UROC1 AMDHD1 HDC CARNS1 HNMT FTCD EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids CYP8B1 CYP4F2 CYP4F3 CYP4A11 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 PTGIS TBXAS1 CYP4F12 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER LIG1 UBA52 POLK POLE RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 RPS27A PCNA POLD3 POLD4 POLD1 POLD2 XRCC1 LIG3 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis STARD3 FDX1 STARD4 FDXR STAR FDX2 STARD6 STARD3NL TSPO CYP11A1 AKR1B1 TSPOAP1 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport PSMA5 PSMA6 EIF2S3 PSMA3 PSMA4 PSMA1 EIF2S2 PSMA2 EIF2S1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCA6 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ABCD1 RPS27A ABCG1 DERL3 ADRM1 DERL1 DERL2 SEM1 ABCB7 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 ABCD2 PSMC2 ABCD3 ABCC10 ABCC11 ABCA10 PEX3 ABCG4 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ABCA5 ABCA4 ABCC1 ABCA9 ABCA7 ABCA8 ABCB10 ABCA12 ABCG8 ABCG5 ABCB6 VCP ABCB4 ABCC4 ABCC9 SEL1L ABCC5 ABCA3 ABCC6 RNF185 ABCB1 KCNJ11 ABCC2 APOA1 RNF5 ABCC3 ERLEC1 PSMD8 CFTR PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PEX19 PSMD3 PSMD1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors CALM1 DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 RB1 CCNE1 CDK2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions ITGA2B COL9A2 CD44 FN1 VTN AGRN ITGB5 ITGA10 CDH1 KDR ITGA9 ITGAM ITGB2 TNC ICAM4 ICAM5 ITGAE COMP IBSP BSG ITGAX ITGB7 ITGAD CD47 JAM2 JAM3 ITGAV ITGA11 FBN1 HSPG2 SPP1 ITGAL F11R ICAM1 PECAM1 COL18A1 ITGB8 THBS1 COL16A1 ITGB6 COL13A1 ICAM2 ICAM3 ITGA8 ITGA4 ITGB1 ITGB3 ITGA5 COL23A1 COL4A2 FGB ITGA3 COL4A1 FGA ITGA2 ITGA1 FGG COL4A4 ITGA7 ITGA6 COL4A3 VCAM1 COL9A1 LUM COL9A3 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis CCNC PPARGC1B MED9 CDK19 CEBPB MED16 MED15 MED17 CCND3 MED12 MED14 MED13 MED10 PCK1 SREBF2 CDK4 NR2F2 MED27 MED26 MED23 MED25 MED24 MED20 CDK8 CEBPD ADIPOQ HDAC3 SMARCD3 CHD9 TGFB1 MBD3 HELZ2 TGS1 EP300 GATAD2B TBL1X GATAD2A PPARGC1A NCOA1 MED1 NCOA2 CREBBP SLC2A4 HDAC2 NCOA6 NCOR1 TBL1XR1 CARM1 CHD4 RBBP4 CHD3 CEBPA RBBP7 KLF5 KLF4 MTA2 TNF RELA MED8 ANGPTL4 MED4 MED6 MED7 NFKB1 LPL UCP1 HNRNPU MTA1 PRDM16 HDAC1 ZNF423 MED30 MTA3 ELOVL3 CIDEA EBF2 MED31 BMP7 FABP4 COX7A1 SMAD1 SMAD4 PLIN1 RXRA PPARG PPARA CD36 EBF1 EGR2 MED19 ADIRF MED18 THRAP3 MED11 ZNF638 MED29 FAM120B MED28 NCOR2 ZNF467 MED22 LEP MED21 WNT1 WNT10B MED13L NCOA3 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands TMEM219 TNFRSF10B PPP1R13B IGFBP3 TNFRSF10A TNFRSF10C TP53BP2 TP73 FAS TP63 TNFRSF10D TP53 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation DHDDS DPM1 DPM2 DPM3 CHST3 GNE PAPSS2 GPC1 GPC3 GPC2 NEU1 HEXB NCAN GPC5 HEXA GPC4 BGN DCN GPC6 CTSA NUS1 ALG11 BCAN VCAN FMOD AGRN GLB1 SRD5A3 GFPT1 DOLK CSPG5 NOTCH2 CSPG4 KERA NOTCH3 NOTCH4 SLC26A2 POMT2 SEMA5A GALNT12 SPON2 SEMA5B SPON1 B3GALT6 THSD7B POMT1 ADAMTS4 ADAMTSL1 LFNG OGN ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 GALK1 ADAMTSL5 ADAMTSL4 ADAMTS1 B4GALT1 ADAMTSL3 ADAMTSL2 MUC12 MUC13 THSD7A MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 PGM1 POMGNT1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 B4GALT7 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 GALT MUC7 MUC4 MUC6 PRELP GALNT3 MUC16 ACAN MUC17 CHSY1 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 B3GAT3 LUM GALE GALM ALG14 ALG13 NOTCH1 MGAT2 PMM2 MPI ST3GAL3 MOGS OMD DAG1 HSPG2 MAN1B1 DPAGT1 ALG8 SDC4 ALG9 SDC2 ALG6 SDC3 ALG2 ALG3 ALG12 ALG1 MPDU1 THBS1 RFT1 CHST14 EXT1 EXT2 B4GAT1 SDC1 CHST6 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias ABCC8 KCNJ11 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm MIXL1 CTNNB1 GATA4 FOXA2 SMAD2 TCF7L2 SMAD4 EOMES SMAD3 GATA6 CXCR4 TBXT SOX17 CDH1 GSC SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections MAGT1 JAK1 VAV1 BRD4 IFNB1 VHL STAT1 TUSC3 BCL2L1 EEF1A1 ZBP1 TBK1 TMEM258 IRF3 VCP GEMIN2 OST4 SNRPD2 SNRPD1 SNRPD3 OSTC STT3A SNRPG STT3B GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 GSK3B CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 YWHAG PDPK1 DDOST DAD1 RBBP4 RBBP7 PTPN11 PTPN6 PDCD1 AP2A1 AP2A2 AP2M1 BECN1 UVRAG MAP1LC3B ISCU AP2S1 GJA1 AP2B1 ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 BTK MGAT1 MGAT2 GOLGA7 PLCG2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 LARP1 EDEM2 MOGS SYK ZDHHC11 MGAT4C ZDHHC9 MGAT4A MGAT4B HSPG2 MAN1B1 ST6GALNAC3 ST6GALNAC4 SDC4 SDC2 VPS33A SDC3 VPS33B ZCRB1 PYCARD G3BP1 G3BP2 CYSLTR1 HNRNPA1 SDC1 CNBP NLRP3 PCBP2 BST2 SFTPD NLRP12 NUP205 ARID4A POM121 IL17F ARID4B FNTA IL17A NUP188 FNTB AAAS IL1R1 POM121C SAP30 BRMS1 NUP42 IFNAR1 PPIH NUP62 PHF21A TPR PPIG CD79B PPIB NUP88 CD79A RAE1 SUDS3 RCOR1 NUP214 IGHM SFN NDC1 BLNK NUP210 HMG20B JAK3 NUP155 IFNGR1 GPC1 IFNGR2 NUP153 NUP93 SIGMAR1 TYK2 GPC3 NUP50 IGHD NUP35 GPC2 NUP54 SAP30L S1PR1 SAP18 GPC5 CRBN GPC4 VPS39 STAT2 VPS18 GPC6 ATG14 VPS11 VPS16 AGRN RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC RCAN3 RPS11 KPNA2 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA VPS41 NPIPB3 VPS45 KPNB1 RPS4Y2 RPS4Y1 HLA-H HLA-C HLA-F HLA-G MBD3 HLA-E NMI ISG15 RPS26 TOMM70 RPS25 IL17RC RPS28 IL17RA RPS29 TLR1 GATAD2B GATAD2A RPS20 TLR2 RPS21 RPS24 RPS23 RPS4X HSP90AA1 RPS3A IKBKB CANX RPS27L IKBKG RPS15A MAP3K7 RPS3 CHUK RPS2 UBA52 FAU RIPK2 HLA-B RELA RUNX1 TRAF3 UBB IKBKE UBC RPS27A NFKB1 NFKBIA PSMC6 MTA1 NOD1 MTA3 NOD2 IRAK2 UBE2I NR3C1 SUMO1 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 ITGA4 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ANO10 HLA-A B2M SH3KBP1 TUBB TUFM YWHAB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 CTSL IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 UBE2V1 IGKV2D-30 IGHV4-59 IGHV1-69 NPM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 CSNK1A1 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N EP300 TAB3 TAB2 TAB1 ITGB1 IRAK1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV CREBBP IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 CHD4 IGKV3D-20 CHD3 TRAF6 NFE2L2 YWHAQ IGLV3-19 IGKV2-30 IGHV2-70 PPIA IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 FKBP1A IGKV1-39 MTA2 IGKV1-33 YWHAE IGHV3-53 REST IGLC7 IGKV5-2 IGKV1-5 IGLC6 YWHAH RBX1 YWHAZ HDAC1 CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI SRPK2 SRPK1 IMPDH1 IMPDH2 NRP1 HSP90AB1 ROCK1 ROCK2 KDM1A FKBP4 NCK1 DDX5 PTGES3 FURIN CUL3 TMPRSS2 ACE2 RB1 HAVCR1 SEC23A NUP107 SAR1B SEC24B SEC24A COMT SP1 SEC24D NUP160 SEC24C NUP85 PIK3R4 RPS27 SEC13 CASP1 TLR9 NUP133 PIK3C3 RIPK3 HDAC2 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 IL6R RIPK1 KEAP1 NUP43 ITCH CHMP2B CHMP2A RANBP2 NUP37 PRMT1 TRIM4 TJP1 SMAD4 SMAD3 ATP1B3 ATP1B2 ATP1B1 ATP1A4 ATP1A3 AKT2 TLR8 ATP1A2 TLR7 AKT3 ATP1A1 AKT1 MASP1 MBL2 RPN2 FXYD4 FXYD3 RPN1 FXYD2 FXYD1 FXYD7 FXYD6 JAK2 IRF7 STING1 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis HSD3B2 CYP11B2 CYP21A2 CGA HSD3B1 LHB LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake NR1H2 RXRB RXRA NR1H3 MYLIP ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions PPIH RPS2 PPIG FKBP1A PPIB ITCH YWHAE UBA52 SFN FAU RELA RUNX1 YWHAH TRAF3 UBB IKBKE UBC RPS27A NFKB1 NFKBIA YWHAZ PSMC6 YWHAB RPS15 RPS14 RPS17 IRAK2 RPS16 UBE2I RPS19 RPS18 TKFC CAV1 SMAD4 SMAD3 BCL2L1 RCAN3 RPS11 KPNA2 EEF1A1 IFIH1 RPS10 RPS13 TBK1 TRIM25 RPS12 RPS9 IRF3 RPS7 RPS8 SIKE1 RPS5 MAVS RPS6 RIGI RPSA NPM1 NPIPB3 SP1 KPNB1 RPS4Y2 RPS4Y1 PYCARD TLR7 PALS1 NMI TOMM70 RPS26 RPS25 RPS28 RPS27 YWHAG HNRNPA1 RPS29 EP300 PDPK1 RPS20 CASP1 RPS21 NLRP3 RPS24 RPS23 RIPK3 PCBP2 RPS4X BST2 RPS3A SFTPD TRAF6 YWHAQ RPS27L PPIA RPS15A STING1 RPS3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 GNAI3 GNGT1 GNG10 GNGT2 GNG12 GNG3 GNG11 GNAI1 GNG13 GNG2 GNAI2 P2RY12 GNG5 GNB2 GNG4 GNG7 GNB1 GNAT3 GNG8 GNB4 GNB3 GNB5 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 IMP4 SNU13 RRP7A PDCD11 ERI1 GAR1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 CSNK1E RRP36 UTP6 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL MTREX RPP38 DIMT1 FTSJ3 EBNA1BP2 DKC1 NHP2 RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 NOP10 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 SENP3 UTP18 C1D DDX21 BMS1 RPP14 DCAF13 KRR1 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 XRN2 NCL MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN MRM1 HSD17B10 MRM2 MRM3 NOP56 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 TRMT112 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L ELAC2 RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A NOP2 NOP58 CSNK1D GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV GYG2 GBE1 GYS2 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells UPK1A EPCAM REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation TNRC6A CD274 TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants KIT PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) ITGA2B MPL SOS1 CRK FN1 SYK PTK2 THPO RASGRP2 GP9 GP1BB GP5 ADRA2C ADRA2B ADRA2A SRC AKT1 BCAR1 GP1BA PDPK1 ITGB3 RAP1B SHC1 FGB FGA RAP1A VWF FGG APBB1IP F2 RAPGEF3 CSK PTPN1 TLN1 RAPGEF4 RASGRP1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R IGF1R HRAS SOS1 IGF2 IGF1 NRAS EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling EPHA10 EFNA5 EFNA4 EFNB2 AP2A1 EFNB1 EPHB2 EFNB3 AP2A2 RASA1 EPHA1 EPHA2 EFNA1 EFNA3 ARHGEF7 EFNA2 NGEF RAC1 AP2M1 MMP9 KALRN LIMK2 LIMK1 MYH14 MYH10 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B MYL12A PAK1 MYL12B AP2S1 PAK3 PAK2 DNM1 MYH11 AP2B1 HRAS GRIN2B ACTB TIAM1 CLTB MYL6 ARPC1B ADAM10 ARPC1A CFL1 VAV3 WASL PTK2 VAV2 SDC2 GRIN1 RHOA CLTCL1 ROCK1 ROCK2 MYH9 ACTG1 ARPC4 CLTC ARPC5 ITSN1 ARHGEF28 ARPC2 CLTA NCK2 GIT1 ARPC3 ACTR3 ACTR2 LYN CDC42 YES1 EPHB6 EPHB1 EPHB4 FYN EPHB3 EPHA5 EPHA4 EPHA7 SDCBP EPHA6 MYL9 EPHA8 MMP2 EPHA3 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2AX MTA2 SMARCB1 DNMT3L SPOCD1 C19orf84 DNMT3A H3-3B SMARCC1 H3C8 SMARCC2 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 SMARCA2 ACTB H2BC1 SMARCA4 ACTL6A H2AB1 H2AC8 H2AC6 BCL7A H2AC7 BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SS18L1 ARID1A ARID1B H2AC19 SMARCD3 H2AC14 H2BC12L MBD3 H2BC26 H2BC21 PIWIL4 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SMARCD1 HDAC2 SMARCD2 H2BC11 H4C9 CHD4 RBBP4 CHD3 RBBP7 SMARCE1 H2AZ2 H2AC20 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH H2AX TMED2 CCNC H3-3B H3C8 H2AJ H3C15 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 MIB2 H2BC1 SNW1 EGF H2AB1 TLE1 H2AC8 H2AC6 H2AC7 JAG2 JAG1 ADAM10 DTX4 DLL1 MIB1 SEL1L DLL4 NEURL1B ADAM17 NEURL1 HDAC3 MAMLD1 H2BC26 H2BC21 EP300 TBL1X H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP H2BC11 NCOR1 TBL1XR1 H2AZ2 TNRC6C TNRC6A TNRC6B JUN MAML2 MAML1 FCER2 PSENEN PSEN2 RAB6A PSEN1 APH1A NCSTN APH1B HES5 HEYL NOTCH1 RBX1 YWHAZ HDAC1 FABP7 ST3GAL4 ST3GAL3 TP53 NCOR2 KAT2B KAT2A ST3GAL6 RBPJ PLXND1 WWC1 DLGAP5 PTCRA PBX1 TACC3 WWP2 FURIN RFNG POGLUT1 POFUT1 MFNG FLT4 MDK ACTA2 CNTN1 NOTCH2 NOTCH3 NOTCH4 HEY1 CCND1 E2F1 NUMB E2F3 HEY2 TFDP1 TFDP2 SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB CDK8 LFNG NBEA EGFR B4GALT1 HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 ELANE GZMB PSMA5 PSMA6 ITCH PSMA3 PSMA4 HDAC10 PSMA1 HDAC11 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRKCI CUL1 PSMA7 PSMB6 RUNX1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DNER TLE4 TLE2 HDAC4 DTX1 DTX2 DLK1 SMAD3 ATP2A3 ATP2A2 ATP2A1 YBX1 H2AC19 H2AC14 H2BC12L MYC AKT1 HES1 ARRB1 ARRB2 HIF1A H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA LINGO1 MAG MCF2 OMG RTN4 RHOA NGF NGFR DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH GGT1 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria KHK BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA ACADS HADHB HADHA ECHS1 HADH DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) FOS NAB1 NAB2 SH3GL3 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 MAPK7 LYL1 F3 SH3GL2 VGF ELK1 ASCL1 RALA CDK5R2 SHC2 RALB SHC3 DNM1 SHC1 DNM3 YWHAB NTRK2 CRKL ADORA2A NRAS RAP1A MAPK1 STAT3 HRAS RALGDS MAPK3 NTRK1 MAP2K1 PLCG1 FOSB MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 DNM2 RIT2 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 RAPGEF1 SOS1 CRK ATF2 IRS1 IRS2 RHOA PIK3CB RPS6KA5 EP300 ID4 EGR1 MEF2D CLTC PIK3CA PPP2R5D MEF2C CLTA CHD4 PPP2CA PPP2CB AP2A1 AP2A2 REST AP2M1 JUNB CDK5 RPS6KA1 ATF1 CDK5R1 MEF2A DUSP4 DUSP3 VRK3 DUSP6 DUSP7 SGK1 AP2S1 AP2B1 ID1 ADCYAP1 ADCYAP1R1 EGR2 TCF12 PIK3R2 SRF PIK3R1 RPS6KA3 RPS6KA2 JUND NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation UBE2M AMER1 KBTBD13 UBE2D1 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 VHL UBE2D2 NEDD8 FBXL19 CAND1 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 VCP COPS5 WDR5 RBBP5 NFE2L2 RBBP7 DCAF13 ELOB COP1 ELOC RBX1 DCAF7 FBXO4 FBXO6 FBXW4 CISH FBXW5 FBXW10 FBXW7 FBXW9 SOCS2 FBXW2 FBXL3 FBXL5 GPS1 SENP8 UCHL3 CUL2 COPS4 COPS2 UFD1 CUL3 KBTBD7 NPLOC4 CDKN1A DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 SQSTM1 DCUN1D5 SKP2 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 COMMD9 PUM2 HIF3A DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 DDB2 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CUL9 UBD NAE1 SOCS6 WDTC1 SOCS5 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B NEURL2 ERCC8 UBE2D3 BIRC5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 LRR1 CCNF BTRC COPS7B KEAP1 COPS7A SKP1 FBXW11 PSMA5 COPS3 PSMA6 COPS6 PSMA3 PSMA4 PSMA1 PSMA2 COPS8 UBA52 FBXO7 PSMD12 FBXO9 PSMD11 WSB1 PSMD14 FBXO2 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 FBXL8 FBXL4 PSMC5 PSMC6 FBXL7 PSMC3 PSMC4 PSMC1 PSMC2 SOCS3 LRRC41 GAN KCTD6 KLHL2 KLHL3 CUL4A DDB1 KLHL9 SPSB2 DTL SPSB1 KBTBD6 CUL4B KLHL5 KBTBD8 SPSB4 FBXO27 FBXO32 BRCA1 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 CUL7 CUL5 KLHL11 EPAS1 UBXN7 KLHL13 FBXO44 FBXO41 FBXO40 HIF1A MUL1 DPP3 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 PALB2 FBXO31 KLHL20 UBA3 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair PARP1 PARP2 POLB APEX1 PARG ADPRS LIG1 FEN1 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation SCN11A SCN9A CALM1 SCN1B SCN1A CACNA2D2 SCN10A SCN8A CAMK2B CAMK2D CAMK2A SCN3B SCN3A CACNA1C CACNG6 FGF14 RANGRF FGF13 FGF12 CACNG7 CAMK2G FGF11 CACNB1 SCN2A CACNB2 SCN2B CACNG8 SCN5A CACNG4 SCN4A SCN4B SCN7A SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins POM121C SUMO2 NUP42 PHC2 NUP62 NUP43 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 RANBP2 PHC3 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 BMI1 NUP160 RING1 NUP85 NUP37 RNF2 HNRNPK SEC13 NUP133 PCGF2 UBE2I NOP58 HNRNPC NUP205 POM121 NUP107 NUP188 SUMO1 AAAS CBX8 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling CSH1 STAT5A PRLR STAT5B RBX1 GHR GH2 GH1 JAK2 CUL1 PTPN11 BTRC PRL SKP1 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes EP300 TKT PGD NFE2L2 CREBBP G6PD TALDO1 MAFG REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells NKX6-1 PDX1 HNF1B PTF1A FGF10 ONECUT3 ONECUT1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA MCM6 MCM2 ANAPC15 ANAPC16 ANAPC7 UBE2C LIG1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ORC5 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 FZR1 SKP2 CCNE2 CCNE1 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 FEN1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 POLE RFC5 RFC3 RFC4 RFC1 RFC2 DNA2 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 GINS1 RPA2 GINS2 CDC45 POLE4 MCM7 GINS3 GINS4 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 MUC12 ST6GALNAC4 MUC13 MUC15 MUCL1 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 ST6GALNAC2 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 ST3GAL4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination NFIA CRCP NFIB NFIC POLR2K POLR2L POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H POLR3K POLR2E POLR2F SSB NFIX POLR2H APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation DFFB DFFA HMGB2 H1-1 KPNA1 H1-0 H1-3 H1-2 H1-5 H1-4 CASP3 KPNB1 HMGB1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) RAD1 ATM RAD9B ATR RAD9A ERCC4 MRE11 ERCC1 BRCA1 RAD52 LIG1 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 DNA2 RHNO1 BLM WRN BRIP1 ABL1 RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration RND1 RRAS MET PLXNB1 RHOA RAC1 SEMA4D ARHGAP35 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling PPP2CA PPP2CB PPP2R1A UBA52 KLB UBB FGF1 FGF2 UBC FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF16 MKNK1 FGF19 FGF18 SPRY2 FGFR4 MAPK1 MAPK3 FRS2 BRAF PTPN11 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1C RB1 CDKN1A CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription CDC6 RRM2 POLA1 RBL2 RBL1 CDK1 ORC1 CCNA1 CDT1 FBXO5 LIN54 PCNA LIN52 LIN37 HDAC1 LIN9 E2F1 E2F4 DHFR TK1 TYMS E2F5 E2F6 TFDP1 RBBP4 TFDP2 CCNE1 CDC45 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation HPN SPINT2 MET HGF HGFAC SPINT1 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate ZNF521 NANOG PAX6 POU5F1 SOX2 ZEB2 ZIC2 SOX1 GBX2 OTX2 POU3F1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair ACD H2AX MPG LIG1 TERF1 TERF2 H2AJ POT1 TERF2IP FEN1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 POLB H2BC1 APEX1 XRCC1 LIG3 H2AB1 H2AC8 H2AC6 H2AC7 POLE H2AC19 H2AC14 RFC5 PARG H2BC12L RFC3 ADPRS RFC4 RFC1 RFC2 H2BC26 H2BC21 OGG1 NTHL1 H2BC17 TDG MBD4 H2BC12 SMUG1 H2BC13 NEIL3 PCNA H2BC14 NEIL2 H2BC15 NEIL1 POLD3 PNKP POLD4 H2BC11 POLD1 POLD2 PARP1 PARP2 H4C9 TINF2 RPA1 RPA2 POLE4 H2AZ2 RPA3 H2AC20 POLE2 POLE3 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 PRELP ACAN ST3GAL3 KERA OGN OMD FMOD LUM RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates ATM MUS81 MRE11 BRCA1 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM NBN GEN1 RMI2 SLX1B RMI1 TOP3A SPIDR SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 SLX4 FIGNL1 RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids ADH7 CYP2A7 CYP4F2 CYP4A11 CYP2B6 CYP2A13 CYP2D6 CYP2F1 CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 CYP2J2 CYP4F12 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNQ2 KCNQ3 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency CPS1 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes EP300 ABCC3 ABCC1 MAFK NFE2L2 ABCG2 CREBBP ABCF2 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly HSP90AA1 IPO5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins ITGA2B ITGB3 SOS1 FN1 PTK2 RAP1B FGB FGA RAP1A VWF FGG APBB1IP TLN1 SRC INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling JAK1 STAT5A STAT3 STAT5B IL2RG IL9 JAK3 IL9R STAT1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 H2BC17 H2BC12 H2BC13 NEIL3 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 NEK7 CDK1 CCNB2 PLK1 NEK9 CCNB1 NEK6 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex CDC6 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease SOS1 FGFR1 FGF1 FGF2 CEP43 FGF4 FGF6 FGF9 FGF20 STAT5A FGF23 STAT5B GAB2 ZMYM2 PIK3R1 PIK3CA NRAS STAT1 GAB1 LRRFIP1 STAT3 HRAS BCR CUX1 FGFR1OP2 PLCG1 MYO18A CPSF6 ERLIN2 FRS2 TRIM24 BAG4 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME ALB SLCO1A2 SLC22A8 ABCG2 SLC22A1 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation ACSM5 ACSM4 GLYAT ACSM1 GLYATL3 ACSM2B GLYATL2 GLYATL1 ACSM2A SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions SDK1 SDK2 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism RMND5B LDHB LDHA MAEA PDPR RMND5A MPC1 MPC2 PDK4 PDK3 PC UBA52 MPC1L NEK1 ME3 DLAT ME2 PDK2 PDK1 PDHX PDHA2 FAHD1 PDHA1 SIRT4 ARMC8 PDP1 DLD UBB MKLN1 GID4 PDP2 UBC GSTZ1 GID8 LDHAL6A RPS27A LDHAL6B VDAC1 ME1 RANBP9 WDR26 GLO1 GPT PDHB LDHC BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding KLB FGF19 FGFR4 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation TBK1 TICAM1 TANK TRAF3 UBB UBA52 IKBKE TLR3 OPTN UBC RPS27A STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses TBK1 IRF3 NLRP4 MRE11 DTX4 TRIM21 CGAS DDX41 PRKDC NLRC3 IFI16 STAT6 XRCC6 XRCC5 TREX1 STING1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium EXOC1 EXOC8 ARF4 EXOC7 ASAP1 PKD2 PKD1 GBF1 RAB11FIP3 RAB11A RHO CNGA2 CNGA4 CNGB1 RAB3IP EXOC4 EXOC3 EXOC6 EXOC5 RAB8A EXOC2 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer RAC1 PDGFRA VAV1 SRC PDGFRB TRAT1 PDGFB NTRK3 PIK3AP1 MET TGFA FLT3LG KIT EREG RAC2 BTC EPGN HBEGF NTRK2 BDNF GAB1 NTF4 NTF3 CD86 EGF ESR1 CD80 FRS2 FLT3 AREG ESR2 CD19 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF PIK3CD IRS2 FGF1 PIK3CB FGF2 ERBB2 PIK3CG FGF3 NRG1 FGF4 STRN FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 PIK3R3 PIK3R2 PIK3CA PIK3R1 FGFR4 FGF10 LCK PIK3R6 PIK3R5 FYN RHOG PTPN11 CD28 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PTPN6 SOS1 SOCS6 PRKCA RAC1 MMP9 CHEK1 VAV1 CBL STAT5A PTPRU STAT5B SH2B3 SH2B2 GAB2 CMA1 FER TEC KIT PIK3R3 FES PIK3R2 GRAP PIK3R1 PIK3CA SOCS1 JAK2 LCK GRB7 GRB10 NRAS STAT1 LYN STAT3 HRAS YES1 FYN GRAP2 PTPN11 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints RAD1 ATM RAD9B ATR H2AX RAD9A ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 MDM2 UBE2S MDM4 CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CCNA2 CCNA1 CDKN2A H2BC9 H3-4 H2BC8 YWHAB H2BC5 H2BC3 H2BC1 MAPK14 MAPK11 CDC6 CSNK1E CSNK1A1 NEK11 GSK3B XPO1 H2BC26 H2BC21 UBE2N YWHAG H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 YWHAQ YWHAE PHF20 CHEK2 GTSE1 CDC25C ZNF385A COP1 PCBP4 CDC25A YWHAH RBX1 YWHAZ PLK3 WEE1 CDC7 TP53 MDC1 CDC45 MCM7 MCM3 MCM4 MCM5 MCM6 MCM2 SFN ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 CDKN1A CDKN1B CCNE2 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 PSMD8 KIF2C KIF2B PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA BTRC AURKB NSL1 SKP1 CENPC PPP2CA PPP2CB FBXW11 NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CLASP1 HERC2 PSMA4 DYNC1I1 PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CUL1 CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 MCM10 PSMC5 PSMC6 DBF4 PSMC3 PSMC4 PSMC1 PSMC2 PKMYT1 PIAS4 BRCC3 CLSPN TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 NSD2 MRE11 BRCA1 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A UBE2V2 HUS1 DNA2 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 RAD50 RPA3 RAD17 INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade SDC1 F3 PROS1 F5 F8 SERPINC1 GPC1 F10 HSPG2 GPC3 VWF GPC2 SDC4 SDC2 GPC5 SDC3 F7 GPC4 F2 F9 GPC6 AGRN MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 CD274 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 COPS5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 NEK2 BTRC SKP1 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation GJA1 DNM2 MYO6 CLTB DAB2 CLTCL1 CLTC DNM1 CLTA AP2M1 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation UBE2L6 FURIN H2AX INS APP UBA52 SNCA H3-3B APOA4 B2M H3C8 UBB PSENEN UBC APH1A SIAH2 NCSTN RPS27A SIAH1 APH1B PRL H3C15 GGA2 GGA1 GGA3 CALB1 H2BC9 NAT8B H2BC8 BACE1 APOE H2BC5 MFGE8 APCS H2BC3 TSPAN33 CST3 TTR H2BC1 TSPAN5 H2AZ1 ODAM SAA1 LYZ SNCAIP SORL1 TSPAN15 H2AB1 TSPAN14 NAT8 SEMG1 GSN TGFBI H2AC8 ITM2B H2AC6 H2AC7 IAPP CALCA ADAM10 HSPG2 H2AC19 H2AC14 H2BC12L NPPA H2BC26 H2BC21 USP9X H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 APOA1 H2BC11 FGA H4C9 LTF PRKN H2AC20 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling RANBP10 HRAS MET RANBP9 SOS1 HGF MUC20 NRAS TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest PRMT1 AURKA EP300 PCNA BAX SFN TP53 CDC25C ZNF385A CCNB1 E2F4 RBL2 RBL1 TFDP1 CARM1 CDK1 TFDP2 GADD45A HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) PARP1 PARP2 RBBP8 POLQ XRCC1 LIG3 MRE11 RAD52 BRCA2 RAD50 FEN1 NBN MMR%REACTOME%R-HSA-5358508.3 MMR MSH6 MSH2 MSH3 PMS2 MLH1 PCNA LIG1 POLD3 POLD4 EXO1 POLD1 POLD2 RPA1 RPA2 RPA3 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors STAB1 SPARC APOB STAB2 DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins DEFB108C CD4 DEFB130A ART1 DEFB130B DEFA1B DEFB4B PRSS3 PRSS2 DEFA6 DEFA4 DEFA5 DEFA3 CCR6 CCR2 DEFB103B TLR1 DEFB105B DEFB129 DEFB128 DEFB131A TLR2 DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation NANOG POU5F1 SOX2 OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins RHO OPN1LW RRH OPN4 OPN3 RGR OPN1SW OPN5 OPN1MW DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism GATA4 INS PAX6 CTNNB1 UCN EXOC8 ACE2 CMA1 EXOC7 VAMP2 FFAR4 STX1A FFAR1 POMC CTSZ P4HB EXOC4 EXOC3 GRP GNAT3 EXOC6 EXOC5 GIP CPB2 EXOC2 EXOC1 CGA AGT TSHB MYO5A INHBA GH1 LHB CTSG SEC11A CGB8 SEC11C PCSK2 RAB27A PCSK1 MYRIP INHA ERO1B KIF5C ISL1 ANPEP KIF5B ACHE KIF5A LEP CPA3 SLC30A8 MME SLC30A5 ATP6AP2 CES1 ENPEP CPB1 GPR119 PLA2G7 IGF1 CRHR2 BCHE DPP4 CLTRN ACE CDX2 FSHB INHBB MBOAT4 INHBC INHBE GZMH CPE SPCS3 REN SPCS2 SPCS1 CTSD GCG GNG13 GNB1 TCF7L2 GNB3 KLF4 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA POM121C NUP42 NUP62 RCC1 NUP43 TPR NUP88 RANBP1 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 XPO1 NUP37 SEC13 NUP133 RANGAP1 NUP205 POM121 NUP107 NUP188 AAAS SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin MBOAT4 INS UCN GH1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 ACHE LEP GCG IGF1 PLA2G7 BCHE CRHR2 KLF4 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib SLC37A4 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD GCLM GCLC TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades PTPN4 UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 DNM1 MAPK10 DNM3 UBE2D2 MAPK1 MAPK3 MAP2K1 CTSV MAPK14 CTSL CTSK MAP3K8 MAPK11 DNM2 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 PIK3R4 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 APOB TAB1 TLR6 IRAK1 TLR2 TLR9 PIK3C3 RIPK3 PPP2R5D MEF2C TRAF2 PELI1 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 GSDMD CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 GSDME CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 ECSIT IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA EEA1 DUSP6 TASL DUSP7 RBSN TLR10 IRF5 TLR5 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 SLC15A4 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 ITGAM ITGB2 SIGIRR BTK PLCG2 S100A1 CD36 IRAK3 TIRAP TP53 UNC93B1 TLR8 TLR7 TLR3 CTSS LGMN CTSB HSP90B1 TIFA ALPK1 CD180 LY86 LBP BPI SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis CD3G CD3D TFRC SH3GL3 SH3KBP1 STAM CBL HGS EPS15 TGFA STAM2 SYT2 SH3GL2 SH3GL1 SYT1 EREG BTC VAMP2 EPGN HBEGF NEDD8 CLTB EGF AREG TF M6PR VAMP8 VAMP7 EGFR COPS5 SCARB2 ITSN2 SLC18A3 AGFG1 GRK3 CLTCL1 KIAA0319 TOR1A TOR1B APOB SYT9 SYT8 SNAP91 DAB2 AAK1 IL7R PICALM CLTC ITSN1 STON1 CLTA STON2 SLC2A8 SGIP1 EPS15L1 EPN1 EPN2 CFTR LRP2 FCHO1 FCHO2 REPS2 UBQLN1 UBQLN2 COPS7B COPS7A NECAP2 CD4 NECAP1 SYT11 COPS3 COPS6 AP2A1 AP2A2 VAMP3 COPS8 UBA52 VAMP4 LDLRAP1 AP2M1 AGTR1 TGOLN2 UBB UBC IGF2R RPS27A AP2S1 AVPR2 LDLR AVP CHRM2 AP2B1 TACR1 ADRB2 WNT5A GRK2 GPS1 DVL2 FZD4 ARRB1 ARRB2 COPS4 COPS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells HRAS RASGRP1 RASGRP3 NRAS PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling HLA-DRB3 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 ASH2L CD3G CUL3 MAGT1 CD3E CD3D PRKAG3 TEAD1 TEAD2 JAK1 TEAD3 H3-3B HLA-DPA1 TEAD4 H3C8 FOS PDCD1LG2 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 YAP1 DERL3 DERL1 DERL2 TRBV12-3 CTNNB1 H3C15 TRBV7-9 OS9 SPOP BRD4 SUZ12 CCND1 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 TRAV8-4 HLA-DPB1 FOSB CDK4 TUSC3 TRAC H2AB1 NEK2 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 GSK3B DPY30 H2BC26 H2BC21 WDR5 YWHAG EP300 EED H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 CREBBP DAD1 LCK IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 ERLEC1 PSMD8 RBBP4 RBBP5 PSMD6 PSMD7 CSK PSMD2 NFE2L2 RBBP7 PSMD3 TCF7L2 PSMD1 H2AZ2 TCF7L1 BTRC PTPN11 SKP1 TNRC6C CD4 PTPN6 PDCD1 PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 JUN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L MYC TRBC1 PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B ATF3 RPN2 EPAS1 RPN1 HIF1A TRAV29DV5 HLA-DQA2 WWTR1 HLA-DRB5 H4C9 HLA-DRB4 JUND ERLIN1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation TFAM POLRMT TFB2M ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis EZH2 H2AX PAX6 ASH2L JUN H3-3B H3C8 H2AJ KMT2D H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 KDM6A H2BC1 POLR2A POLR2B POLR2C H2AB1 POLR2D POLR2E RXRA POLR2F RARG POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 RARA POLR2J POLR2K POLR2L CNOT6 KMT2C EGR2 HOXA2 HDAC3 CNOT9 RARB H2AC19 H2AC14 H2BC12L PAXIP1 DPY30 H2BC26 H2BC21 WDR5 EP300 EED H2BC17 HOXB4 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP CTCF NCOA6 PCGF2 PAGR1 H2BC11 HOXA3 HOXA1 PKNOX1 HOXA4 NCOR1 NCOA3 PIAS2 HOXB3 H4C9 HOXB2 RBBP4 HOXB1 RBBP5 YY1 AJUBA HOXD1 HOXC4 RBBP7 PBX1 MEIS1 H2AZ2 MAFB H2AC20 HOXD4 HOXD3 ZNF335 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein POM121C NUP42 NUP62 RCC1 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NPM1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ14 KCNJ12 KCNJ2 KCNJ4 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism MTMR10 TNFAIP8 MTMR12 PITPNB MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 INPPL1 SBF2 TPTE2 RUFY1 INPP4A INPP4B INPP5D PI4K2A INPP5J PIP4K2A VAC14 PIP4K2B MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 SYNJ1 GDPD3 TPTE GDPD5 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 FIG4 PIKFYVE PI4KB PNPLA6 PI4K2B MTMR2 SACM1L RAB4A PI4KA ARF1 SBF1 PTPN13 PIP4P1 RAB5A PTEN MTMR4 PIK3R4 PIK3CD PIK3CB PIK3CG PIP5K1C SYNJ2 INPP5E PIK3R3 PIK3C3 PIK3R2 PIK3CA PIK3R1 PIK3R6 PIK3C2A PIK3R5 OCRL RAB14 ARF3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 LYN EPO STAT5A STAT5B IRS2 JAK2 EPOR SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 ITPK1 PPIP5K2 IP6K1 NUDT3 IP6K3 NUDT4 IPPK NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes ATF4 EP300 MAFK NFE2L2 CREBBP SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP GDF2 SMAD6 SMAD9 SMAD5 SMAD7 GREM2 INHBA ZFYVE16 BMPR1B ACVR2A BMPR1A TGFBR3 UBE2D1 INHA SKI BMP2 UBE2D3 ACVRL1 BMP10 SMAD1 BMPR2 SMAD4 AMHR2 FSTL1 CHRDL1 SMURF2 ACVR2B AMH CER1 SMURF1 NOG GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling GGT3P GGT5 GCLC OPLAH GCLM CNDP2 CHAC2 CHAC1 GGCT GGT7 GSS GGT6 GGT1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System SYT10 PRKAG1 PRKAG2 PRKAG3 RAC1 MDM2 KCNK6 KCNK7 KCNK1 SRC NRAS MAPK1 GRIN2B HRAS MAPK3 HOMER3 EPB41 CHRNA1 STXBP1 CHRNB2 EPB41L5 CHRNB4 EPB41L2 CHRNA3 HOMER1 CHRNB3 HOMER2 CHRNA2 PPFIBP1 CHRNA5 PPFIBP2 CHRNA4 PTPRS CHRNA7 PTPRF CHRNA6 SIPA1L1 CHRNA9 DLGAP1 CHRND DLGAP3 CHRNG DLGAP2 CHRNE DLGAP4 BEGAIN APBA3 APBA2 LRRC4B SYT7 PTPRD LRFN3 LRFN2 LRFN4 LRFN1 LRRTM3 LRRTM4 KCNJ8 LRRTM1 ABCC8 PDPK1 SYT9 LRRTM2 IL1RAPL2 IL1RAPL1 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 GIT1 NLGN2 NRXN1 NRXN3 PRKAA1 NRXN2 PRKAA2 SLITRK2 SLITRK1 SLITRK4 SLITRK6 PDLIM5 NLGN4Y NLGN4X SYT12 SLITRK3 SLITRK5 CALM1 AP2A1 PRKACG PRKACB GLS SLC1A1 SLC1A2 RPS6KA1 SLC1A3 SLC6A3 SLC1A6 SLC5A7 SLC1A7 SLC38A2 SLC38A1 SLC6A12 GNGT1 GNGT2 GNAT3 ADCY9 PRKAR1B PRKAR2B GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ACTN2 ADCY8 GNG10 GRIN2C ADCY7 PRKAR2A ADCY6 PPM1E GNG3 GNAI1 PPM1F GRIN2D ADCY5 GNG2 GNAI2 GRIN1 GRIN2A GNG5 DLG2 GNG4 LRRC7 GNG7 CAMK4 GNG8 NEFL CAMK1 AKAP5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 MYO6 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 KCNN1 KCNN3 GNB2 KCNN4 KCNF1 GNB1 KCNC1 GNB4 KCNK9 KCNC2 GNB3 KCNC3 GNB5 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNMB1 RTN3 KCNA10 KCNMA1 HCN4 HCN3 KCNN2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNQ2 KCNA7 KCNQ3 GAD1 KCNJ1 KCNB1 GAD2 KCNB2 KCNJ14 KCNS1 DBNL KCNS2 KCNS3 KCNK2 HCN2 KCNK3 HCN1 KCNK4 GJC1 PANX1 GJD2 PANX2 GJA10 SNAP25 SYT2 SYT1 VAMP2 STX1A KCNQ4 EPB41L3 GRIP1 RPS6KA6 NSF PRKCG CASK GABRG3 KPNA2 HSPA8 GABRG2 GRIP2 GRIA1 LIN7A LIN7C LIN7B ABAT EPB41L1 ARL6IP5 TSPAN7 GLUL GRIA3 UNC13B GRIA4 CACNA2D1 GRIN3B SLC6A13 GNAL CACNA2D3 GRIN3A CACNA2D2 NBEA SLC6A11 GABRB3 SLC22A2 GABRB2 COMT SLC22A1 GABRB1 ACHE RASGRF2 SLC6A1 RASGRF1 KIF17 SLC6A4 SLC18A2 NRGN GABRR3 SLC18A3 GABRR2 SLC32A1 DLG1 GABRR1 SYN3 DLG3 SYN2 DLG4 NPTN GRIK5 SYN1 HTR3E GRIK3 ALDH5A1 HTR3C GRIK4 SLC17A7 HTR3D GRIK1 BCHE HTR3A GRIK2 RAB3A NRG1 RIMS1 HTR3B NCALD ARHGEF9 PPFIA1 PICK1 PPFIA4 CAMKK1 PPFIA3 CAMKK2 PPFIA2 GLRA1 CACNB1 GLRA2 CACNB2 CACNB3 FLOT1 CACNG8 GLRA3 CACNB4 NAAA CACNG2 TOMT FLOT2 CACNG3 CHAT KCNJ2 CACNA1B CACNG4 CACNA1A KCNJ3 GABRA2 CACNA1E GABRQ CPLX1 DNAJC5 KCNJ4 GABRA1 GLS2 TSPOAP1 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GABRA6 GABRA5 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GLRB APBA1 PRKCB GRIA2 ALDH2 NTRK3 SHARPIN PRKACA ABCC9 PRKCA PLCB3 PLCB1 PLCB2 CAMK2B CAMK2D CAMK2A MAOA PRKAR1A PRKAB2 CAMK2G KCNJ11 PRKAB1 GRM1 GRM5 RPS6KA3 RPS6KA2 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 RXRB PLIN1 RXRA NR1H3 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives GPX1 ALOX15 GPX4 ALOX12B ALOX12 ALOXE3 GPX2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape H2AX H3-3B TBP H3C8 H2AJ RRN3 H3C15 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CCNH H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 UBTF H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 H2AZ2 H2AC20 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle NISCH CPD KCTD13 PKP4 PLEKHG5 EPHA2 RASAL2 ARHGAP21 MUC13 KTN1 VANGL1 ROCK1 DDX4 FLOT2 SCRIB PIK3R2 PIK3R1 PICALM TMOD3 DSP TXNL1 ARHGAP5 ARHGAP35 DSG1 WDR6 FAM83B RBMX ANKRD26 DST CAV1 TNFAIP1 PTPN13 CCDC88A RND3 LEMD3 CKB VANGL2 SEMA4F DEPDC1B UBXN11 CKAP4 DLG5 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib HSP90AA1 CDC37 ERBIN ERBB2 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins FURIN PCSK6 PCSK5 NGF FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 SAA1 FPR2 HEBP1 APP FPR1 ANXA1 FPR3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAA2 PRKAB1 PRKAG1 PRKAG2 PPARGC1A MAPK14 PRKAG3 PRKAB2 MAPK12 MAPK11 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ATM H2AX HERC2 UBA52 CHEK2 UBB UBC RPS27A MAPK8 H2BC9 H3-4 PIAS4 H2BC8 H2BC5 ABL1 H2BC3 UBE2I H2BC1 BRCC3 SUMO1 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 NBN H2BC12L SMARCA5 PPP5C H2BC26 UBE2V2 BAP1 UBXN1 H2BC21 BAZ1B APBB1 UBE2N KDM4A MDC1 H2BC17 EYA1 EYA2 H2BC12 H2BC13 EYA3 H2BC14 EYA4 H2BC15 H2BC11 BARD1 H4C9 KDM4B RAD50 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA DBT BCKDHB LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome WDR5 RBBP5 ASH2L DPY30 KMT2D STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation STAT5A STAT5B GAB2 FLT3LG FLT3 PTPN11 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle CDC14A AURKA PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 RB1 PSMC1 PSMC2 FZR1 SKP2 CDK2 NEK2 BUB1B CDC20 FBXO5 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC AURKB SKP1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 CPSF1 NUP85 CPSF4 CPSF3 EIF4E CPSF2 WDR33 NUP37 FIP1L1 SYMPK SEC13 NUP133 SLBP NUP205 POM121 NUP107 NUP188 AAAS SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins IL6 JAK1 CXCL8 H3C8 FOS VAV1 MAPK9 H3C15 MAPK8 MAPK7 PAK2 MAPK10 STAT1 STAT3 CD86 BCL2 CD80 BCL2L1 MAP3K8 LCN2 TBK1 NFKB2 HGF PIK3CD PIK3CB ALOX5 PTGS2 IL1RAPL1 IL7R PIK3CA LCK CDC42 FYN PTPN11 IL32 CD4 PTPN6 CNTFR CNTF IL20RA IL20RB CSF3 IL22RA2 IL1RN IL31RA TNF IL22RA1 IL12B TOLLIP IL12A HAVCR2 IL10RB CTF1 IL1R2 IL10RA CLCF1 IL13RA2 LIF IL13RA1 TNFRSF1B FSCN1 TNFRSF1A FCER2 NDN MCL1 IL21R IL36A IL36B LGALS9 IL15RA IL36G IL1F10 IL21 IL22 IL20 IL25 IL26 STXBP2 IL24 IL11 IL15 IL19 HCK IL17RE OSMR IL17RB RHOU IL33 MAP3K3 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IFNL2 IL1RL2 PTK2B P4HB IFNL3 NOS2 CISH F13A1 SOCS2 CFL1 CTSG SYK TP53 TALDO1 IGHG4 IGHG1 IL10 TIFA TCP1 ALPK1 SDC1 HNRNPA2B1 IL17F IL17A IL1R1 GATA3 BLNK IL2RG JAK3 INPPL1 MMP9 INPP5D TYK2 S1PR1 STAT2 COL1A2 HNRNPF SNRPA1 CEBPD TGFB1 IL17RC IL17RA RPLP0 HSP90AA1 PSMD8 RORC IKBKB CANX PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 MTAP PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 PSMA7 MYD88 RELA PSMB6 PSMB7 PSMB4 PSMB5 ATF1 UBB PSMB2 PSMB3 NKIRAS1 NKIRAS2 UBC IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 SEM1 IRAK4 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 LRRC14 PSMC1 PSMC2 USP14 NLRX1 FOXO1 PELI3 PELI2 NFKBIB SOCS3 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 RORA S100B TNIP2 SAA1 ALOX15 PTPN18 IL37 PTPN20 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 CD36 IRAK3 IRF4 MAOA SOX2 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CCL2 IL2RA LAMA5 SOD1 PTPN4 FN1 CBL PSME2 RALA SHC1 CRKL MAPK1 SMARCA4 MAPK3 MAP2K1 IL4 IL18RAP MAPK14 IL13 IL6ST MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 RAG2 CRK RAG1 UBE2V1 TSLP IL7 BRWD1 CRLF2 ATF2 VEGFA ICAM1 ZEB1 RPS6KA5 HMOX1 UBE2N TAB3 TAB2 TAB1 ITGB1 IRAK1 MEF2C IL2 IL3 VCAM1 TRAF6 IGHE PPIA CCR5 NANOG APP JUN FASLG SOD2 FOXO3 IL34 IL16 CSF1 IFNLR1 LMNB1 IFNL1 TXLNA PTPRZ1 PRTN3 JUNB STX3 RPS6KA1 RBX1 YWHAZ POMC ITGAM ITGB2 ITGAX ANXA2 GSTA2 CA1 STAT5A STAT5B PIM1 GRB2 POU2F1 SOS2 VIM FPR1 CSF2 MMP2 CCL11 CCL19 CCL22 MSN CCL20 SNAP25 CSF1R ELK1 CDKN1A CXCL10 VAMP2 STX1A CCND1 ANXA1 SQSTM1 CCL5 ARF1 CCL4 CCL3 PTPN12 HSPA8 PPP2R1B VAMP7 PPP2R1A SOCS5 BCL6 GSTO1 CCR1 IRS1 IRS2 FGF2 CCR2 HMGB1 CASP8 GAB2 OPRD1 CASP1 MUC1 IL18 IL9 PPP2R5D TRAF2 IL9R IL1A IL1B PELI1 BIRC5 CSF3R IL6R CCL3L3 GSDMD PPP2CA PPP2CB CXCL1 CXCL2 TWIST1 HSPA9 TEC LIFR CASP3 STX4 PTAFR SMAD3 CAPZA1 TIMP1 PRKACA OPRM1 IFNG MYC AKT1 HSP90B1 MMP3 PIK3R3 LBP PIK3R2 PIK3R1 HIF1A RAP1B SOCS1 JAK2 LYN RPS6KA3 RPS6KA2 MAP2K3 YES1 MAP2K4 STAT6 MAP2K7 MAP2K6 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CUL3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 DVL1 PSMC3 DVL2 PSMC4 DVL3 PSMC1 PSMC2 PSMD8 KLHL12 PSMD6 HECW1 PSMD7 PSMD2 PSMD3 PSMD1 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins POM121C NUP42 NUP62 RCC1 NUP43 TPR NUP88 RANBP1 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NPM1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 XPO1 NUP37 SEC13 NUP133 RANGAP1 NUP205 POM121 NUP107 NUP188 AAAS LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CTNNB1 LRRFIP1 EP300 IRF3 CREBBP RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle RAC1 MTMR1 TFRC VAV1 SCFD1 ATP6AP1 PAK1 PAK3 PAK2 DOCK3 FRS3 TIAM1 HMOX2 JAG1 VCP ITSN2 DBT RTKN SOWAHC ARHGEF10L STK10 AKAP13 SLK ARHGEF11 ARHGEF10 NCKAP1 ARHGEF12 NCF1 ARHGEF17 STARD8 NCF2 NCF4 RHOB CIT SNAP23 DAAM1 BRK1 ARHGAP6 ARHGEF3 ARHGEF1 DOCK10 ARHGEF2 SYDE1 PKN3 ARHGAP42 PIK3CA BAIAP2L1 ARHGEF25 PICALM RAC3 ARHGEF28 IQGAP3 LCK GIT1 SWAP70 STOM RHPN2 ARAP2 CYBB ECT2 STARD13 ARAP3 JUP OCRL CAVIN1 CYBA BCR CDC42 PCDH7 AMIGO2 MYO9A NET1 NOXO1 ANLN ARHGAP17 ARHGAP15 DIAPH1 ABR CSK ACTC1 RACGAP1 DLC1 PKN2 SLITRK3 PKN1 NHS TNFAIP1 SLITRK5 RND3 NCKAP1L CKB WASF1 SEMA4F WASF2 ARHGEF40 CKAP4 NISCH PLEKHG2 IL32 KCTD13 GIT2 ARHGEF15 PLEKHG5 TRIP10 ARHGAP26 BAIAP2 ARHGEF19 TAOK3 RHOC ABI2 TIAM2 OBSCN NOXA1 ABI1 ARHGEF4 NOX3 ARHGEF7 NGEF NOX1 FERMT2 ARHGEF6 FGD1 C1QBP FGD2 GNA13 FGD3 FGD4 ARHGEF39 PLXNB1 SLC1A5 RHOU GJA1 ACTB PTK2B CYFIP2 WIPF1 WIPF2 WDR91 WIPF3 ANKFY1 WDR81 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 FGD5 CHN2 WASL CHN1 FARP1 DEF6 WDR11 VMA22 WAS SHKBP1 GOPC FILIP1 FAM13B CCT6A FAM13A POTEE GOLGA8R RALGAPA1 FAM91A1 TEX2 ARMCX3 DDRGK1 TUBA1B NSFL1C ARHGAP11A ZNF512B ARHGAP11B TAGAP CCT2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 BLTP3B SH3BP1 WHAMM GOLGA3 BAIAP2L2 SPATA13 TMEM87A FAF2 AKAP12 HINT2 GRB7 SH3PXD2A STMN2 RHOH KIF14 RHOF RHOD RND1 STIP1 RHOV EPSTI1 PLEKHG4B WDR6 EMC3 CCT7 PLXNA1 PRAG1 PLXND1 WASF3 SYDE2 FAM83B ANKRD26 ARHGAP44 DST DOCK11 RRAS2 BCAP31 ARHGAP40 BASP1 ALDH3A2 TMEM59 RALBP1 CCDC88A KCTD3 PREX2 FAM135A ARHGAP45 VANGL2 ARHGAP19 ARHGAP18 UBXN11 AAAS TOR1AIP1 DLG5 CPD ARHGAP12 WWP2 PKP4 ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 RASGRF2 USP9X ARHGEF9 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 FMNL3 HSP90AA1 ARHGAP39 SRGAP3 SRGAP2 SRGAP1 DOCK7 SENP1 SRRM1 PTPN13 DDX39B CCP110 CEP97 ARHGAP10 SRC STAM HGS STAM2 FARP2 PLD2 KIDINS220 FRS2 RAPGEF1 SOS1 PARD6B ARHGEF18 RHOA PARD6A PGRMC2 ARL13B DDX4 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L CFTR ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 RAB7A EPHA2 VAMP3 ARHGEF26 GARRE1 SHMT2 PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 LMNB1 STX5 YKT6 PAK4 NDUFA5 MCF2 MCAM ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 ABCD3 RAC2 CAV1 VAV3 VAV2 UACA HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 PAK6 MSI2 PAK5 RHOBTB1 MYO9B ACTG1 RHOBTB2 TRA2B MYO6 ABL2 STK38 RBBP6 RNF20 SPEN CPSF7 TMOD3 NCK2 ACTN1 NCK1 TXNL1 COPS4 COPS2 CDC37 PHIP SOS2 PDE5A VIM HNRNPC RBMX DBN1 CUL3 RASAL2 SPTBN1 LAMTOR1 SPTAN1 TPM4 TPM3 MTR MUC13 LBR FLOT1 NUDC FLOT2 SAMM50 MTX1 SH3RF1 STEAP3 DSP DSG1 DSG2 CAPZB TJP2 PIK3R3 IQGAP1 PIK3R2 PIK3R1 ZAP70 MAP3K11 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance ALDOB MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A SGSH REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane FURIN POMT1 PCSK6 TMEM258 SEC11A MOGS SEC11C ANK3 OST4 OSTC STT3A CSNK2A3 ARHGAP32 PIP5K1C CSNK2A1 CDH1 CSNK2A2 CSNK2B CTNNB1 PCSK7 RPN2 DDOST SPCS3 RPN1 SPCS2 SPCS1 DAD1 JUP PRKCSH CANX POMT2 GANAB NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors P2RY10 LPAR6 P2RY11 ADORA3 ADORA1 P2RY6 ADORA2A P2RY2 P2RY4 P2RY1 ADORA2B P2RY12 LPAR4 P2RY13 GPR17 P2RY14 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes SYT10 ARNT INS ARNT2 CREBBP NAMPT RBFOX3 BDNF NPAS4 MDM2 IQSEC3 MAPK1 CDK5 MAPK3 FOS BMAL1 CDK5R1 RET XPO1 PLK2 GEM DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A1 MAN1A2 MAN1C1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ECI1 HADHA ACADM ACADL DECR1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HIF1A HBEGF EGFR PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs RAB7A YWHAE TRAPPC2L SBF2 TRAPPC6A TRAPPC6B RAB1A ALS2 RAB1B RAB6A RAB6B RIC1 RGP1 RAB8A RAB9A TRAPPC2 RAB9B TRAPPC3 TRAPPC1 RABGEF1 TRAPPC10 RAB27B DENND1C TRAPPC4 DENND1B TRAPPC5 GDI1 TRAPPC9 DENND5B DENND1A GDI2 RINL TRAPPC12 TRAPPC11 RAB8B DENND5A TRAPPC13 DENND2D DENND2C SBF1 DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 RAB35 DENND6A RIN1 RIN2 ULK1 DENND3 RAB7B RAB21 ALS2CL CHM CHML ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB27A RAB39B TRAPPC8 RAB12 RAB18 RAB5B RAB3GAP2 RAB5C RAB3GAP1 MON1A MON1B RAB5A GAPVD1 AKT2 AKT3 AKT1 RAB3A RAB10 RAB14 RAB13 RAB3IP GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNGT1 GNGT2 GNAT3 GABRG3 ADCY9 GABRG2 GNAI3 GNAL ADCY4 GABRB3 ADCY3 GABRB2 GABRB1 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 GABRR3 GNAI1 GABRR2 ADCY5 GNG2 GABRR1 GNAI2 NPTN GNG5 GNG4 GNG7 GNG8 ARHGEF9 KCNJ2 KCNJ3 GABRA2 GABRQ KCNJ4 GABRA1 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GNG12 GABRA6 GNG11 GABRA5 GNG13 KCNJ12 KCNJ9 GNB2 GABRA4 GABRA3 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation CHUK PPP2CA PPP2CB FBXW11 JUN UBA52 CUL1 RIPK2 RPS6KA1 FOS ATF1 UBB UBC MEF2A RPS27A DUSP4 DUSP3 NFKB1 VRK3 MAPK9 DUSP6 MAPK8 DUSP7 MAPK7 ELK1 MAPK10 NOD1 NOD2 IRAK2 MAPK1 MAPK3 TNIP2 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 RPS6KA5 UBE2N TAB3 TAB2 TAB1 IRAK1 PPP2R5D MEF2C RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion HSD17B10 TRNT1 ELAC2 TRMT10C PRORP ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSME2 PSMA5 PSMB10 PSMA6 PSMA3 PSMA4 PSMB8 PSMA1 PSMB9 PSMA2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction RAPGEF1 SOS1 RASA1 CRK PDGFRA SRC PIK3CB PDGFRB BCAR1 PDGFB STAT5A STAT5B PIK3R2 PIK3R1 PIK3CA NCK2 GRB7 NCK1 CRKL NRAS STAT1 STAT3 HRAS PLCG1 STAT6 PTPN11 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS MAPKAPK3 MAPKAPK2 SOS1 RALA SHC2 RALB SHC3 SHC1 NRAS HRAS RALGDS NTRK1 MAPK14 NGF MAPK12 MAPK13 MAPK11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRB3 ADRA2C ADRA2B ADRA2A ADRB1 ADRB2 ADRA1D ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes EP300 MAFK NFE2L2 CREBBP CCL2 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes H2AX ASH2L CCNC MEN1 PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 CXXC1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2A KMT2C GPAM SCD ADIPOQ HDAC3 KAT8 PHLDA1 ACSL1 HCFC2 WDR82 PEX11A BOD1L1 DPY30 MBIP TASP1 KAT14 H2BC26 DR1 H2BC21 BOD1 CIDEC WDR5 TADA2A EP300 ZZZ3 YEATS2 TBL1X TADA3 H2BC17 AKAP8L SGF29 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 PHF20L1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 KANSL1 CREBBP KANSL2 KANSL3 NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 MCRS1 PDK4 PHF20 OGT ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL KMT2B LIPE DGAT2 MED30 SETD1B MED31 SETD1A KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 KAT2B KAT2A H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 HCFC1 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 PSIP1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol CYP8B1 NCOA1 NCOA2 AKR1C3 HSD3B7 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP7A1 CYP27A1 RXRA ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) LYN EPO PLCG2 PLCG1 IRS2 JAK2 EPOR REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death TNFRSF10B TNFRSF10A ITCH FAS FASLG UBA52 STUB1 OGT UBB MLKL UBC RPS27A TRADD UBE2L3 CASP8 FLOT1 TNFSF10 FLOT2 PDCD6IP RIPK3 TRAF2 HSP90AA1 CDC37 PELI1 BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 FADD TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade PTPN4 UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 DNM1 MAPK10 DNM3 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 DNM2 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 RIPK3 PPP2R5D MEF2C TRAF2 PELI1 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 ECSIT IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 ITGAM ITGB2 SIGIRR BTK PLCG2 S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 CD180 LY86 LBP BPI SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PPIA ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation CFD C3 CFB GZMM DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency TCN2 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway DUSP16 PPP2CA PTPN7 PTPN3 PPP2CB PPP2R1B PPP2R1A UBA52 UBB PPP5C UBC RPS27A DUSP4 PPP2R5E DUSP6 DUSP7 ARAF PEBP1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C YWHAB BRAP MARK3 NRAS KSR1 MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 RAF1 DUSP10 DUSP5 BRAF DUSP2 DUSP1 PAQR3 MAPK12 DUSP8 DUSP9 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) MYD88 TLR5 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis ALAS2 ALAS1 FECH COX15 UROS CPOX PPOX ALAD UROD HMBS ABCG2 COX10 ALB DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses IFIH1 EXOC1 TRIM25 DDX3X MAVS VTN CDC73 SKIC8 STAT2 CTR9 RTF1 IKBKE HSP90AB1 LEO1 PAF1 UBR4 MBL2 C4A C1QA C4B_2 C1S RBM10 APOA1 CGAS HSP90AA1 CLEC5A C4BPA C4BPB CLU STING1 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance PCSK9 AP2A1 APOB LIPA AP2S1 AP2A2 LDLR CLTC LDLRAP1 CLTA AP2M1 AP2B1 NCEH1 LSR NPC1 SOAT1 SOAT2 NPC2 CES3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PRICKLE1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 WNT5A SMURF2 SMURF1 PARD6A FZD1 FZD3 FZD2 DVL2 FZD5 FZD4 SCRIB FZD7 FZD8 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VANGL2 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins PHC2 PHC1 CBX4 CBX2 PHC3 DNMT3B PCGF2 DNMT3A DNMT1 UBE2I BMI1 RING1 SUMO1 CBX8 RNF2 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 GALNT1 DCTN2 DCTN3 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNC1H1 ACTR1A PLA2G4A RAB18 DCTN6 RAB3GAP2 DCTN5 RAB3GAP1 DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 GALNT2 PAFAH1B2 RAB6A RAB6B DCTN1 DYNLL1 AGPAT3 DYNLL2 CAPZB PAFAH1B1 DYNC1I2 CAPZA1 CAPZA2 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development RAC1 TEAD1 YAP1 PAK1 MAPK7 PAK3 PAK2 GAB1 GRIN2B TIAM1 PLCG1 ADAM10 GSK3B PIK3CD CLTCL1 PIK3CB PIP5K1C ARHGEF11 ARHGEF12 RHOB SHANK3 PIK3CA ARHGEF28 GIT1 COL4A2 COL4A1 COL6A2 COL4A4 CDC42 COL6A1 COL4A3 FYN COL9A1 COL6A3 PTPN11 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 AP2A1 RHOC AP2A2 ARHGEF7 PRKACG NGEF PRKACB ELOB AP2M1 ELOC NCBP1 NCBP2 PLXNB1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B AP2S1 AP2B1 ACTB ARPC1B ARPC1A CFL1 WASL SDC2 GRIN1 MYH9 ARPC4 ARPC5 ARPC2 ARPC3 GRB7 ACTR3 ACTR2 RND1 PLXNA1 PLXND1 MYO10 MYL9 GPC1 MMP9 AGRN RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPS6KA6 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 EGFR RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 PSMD14 ARHGAP39 PSMD13 SEMA4D SLIT2 SRGAP3 LIMK2 PSMA7 SRGAP2 LIMK1 SRGAP1 RRAS ROBO1 MYH14 PSMB6 MYH10 PSMB7 PSMB4 PSMB5 DPYSL4 UBB DPYSL5 PSMB2 DPYSL3 PSMB3 UNC5C UBC UNC5D PSMB1 AGAP2 RPS27A DSCAML1 ADRM1 PLXNC1 SEMA6A SEM1 SEMA6D PSMC5 UTRN PSMC6 SEMA7A PSMC3 RAP1GAP PSMC4 PLXNA2 PSMC1 MBP PSMC2 PLXNA3 PTPRC PTPRA PLXNB3 TREM2 ADGRV1 SEMA3A NTN4 SEMA3E EIF4A3 CASC3 ABLIM1 ABLIM2 ABLIM3 MAGOH SEMA4A ARTN PRX GFRA3 RGMB GFRA2 RGMA GFRA4 DRP2 CD72 SCD5 MPZ NRTN DSCAM DOK1 DOK2 TYROBP DOK4 DOK5 DOK6 ADGRG6 CACNA1S RBM8A PRNP PSPN HJV PRKCA CRMP1 HMGCR PDLIM7 PMP22 UPF3B MAGOHB RNPS1 POU3F1 PITPNA ITGA5 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 LAMA2 LAMA1 NEO1 LAMB1 LAMC1 SH3KBP1 SRC MET SH3GL2 SHC3 SHC1 NRAS FARP2 MAPK1 HRAS SMARCA4 MAPK3 MAP2K1 MAP2K2 FRS2 PRKCQ SOS1 RHOA GFRA1 RPS6KA5 GDNF ITGB1 TRIO ITSN1 ARHGAP35 LDB1 PPP3CB DOCK1 EPHA1 EPHA2 KALRN UNC5A PAK4 CDK5 RPS6KA1 UNC5B CDK5R1 POU3F2 RBX1 SOX10 RET VAV3 ITGAV PTK2 EGR2 DAG1 HOXA2 ISL1 PFN1 VAV2 PFN2 GSPT2 GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 AKAP5 ZSWIM8 PAK6 PAK5 CAP2 MYO9B ACTG1 MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 EPHB6 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 RPS6KA4 EPHA3 ALCAM ITGA2B EPHA10 SCN11A EFNA5 DPYSL2 EFNA4 SCN9A EFNB2 NRCAM EFNB1 EPHB2 EFNB3 SCN1B EFNA1 RASA1 SCN1A EFNA3 ANK2 EFNA2 ANK3 ANK1 SHTN1 SCN10A SCN8A KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 NCAN ST8SIA4 SPTA1 MAG SCN3B SCN3A SPTBN1 NAB1 SPTBN2 NAB2 CNTN6 RDX MSN L1CAM ST8SIA2 KIF4B KIF4A ITGA10 CNTN1 EIF4G1 CNTN2 CD24 SCN2A CACNA1H MYL12A SCN2B NRP2 CNTNAP1 MYL12B CHL1 CACNA1G CACNA1I SCN5A SPTAN1 LYPLA2 SPTB MYH11 DNM1 DNM3 GAP43 DCX ABL1 NUMB SCN4A SCN4B ITGA9 SCN7A NCAM1 RANBP9 CLTB NFASC SREBF2 MYL6 PLXNA4 SEMA5A HSPA8 DNM2 CYP51A1 DLG1 DLG3 CACNA1C DLG4 IRS2 RPS27 CACNB1 CACNB2 CACNB3 GAB2 CACNB4 HDAC2 ITGA2 ITGA1 SDCBP CLASP1 CLASP2 RELN DAB1 VLDLR SIAH2 SIAH1 FES CACNA1D PRKACA ERBB2 CSNK2A1 CSNK2A2 CSNK2B ITGB3 PIK3R3 PIK3R2 PIK3R1 GRB10 LYN RPS6KA3 RPS6KA2 WWTR1 YES1 TLN1 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance PPP6C ACD H2AX PPP6R3 LIG1 H3-3B TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP ANKRD28 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 DAXX ATRX H2BC1 GAR1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 KNL1 NPM1 TERT H2BC26 H2BC21 DKC1 H2BC17 NHP2 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RUVBL1 NOP10 RBBP4 ITGB3BP RBBP7 H2AZ2 CENPA CENPC CENPT CENPU PRIM2 CENPH PRIM1 CENPI POLA1 HJURP POLA2 CENPK RSF1 CENPL MIS18BP1 CENPM OIP5 CENPN CENPW CENPX CENPO MIS18A CENPP CENPQ CENPS FEN1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L DSCC1 RUVBL2 SHQ1 PIF1 H2AC19 CHTF8 H2AC14 CTC1 RFC5 H2BC12L CHTF18 RFC3 WRAP53 STN1 RFC4 TEN1 SMARCA5 RFC1 RFC2 DNA2 BLM RTEL1 PCNA POLD3 POLD4 WRN POLD1 POLD2 H4C9 TINF2 RPA1 RPA2 H2AC20 RPA3 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways CD3G RAC1 IL6 VAV1 MAPK8 IGHV3-23 IGLV IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 ADAM17 IGHV4-59 IGHV1-69 IGLV2-11 NFKB2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 HMOX1 C3 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 CYBA V1-7 V5-1 CDC42 V1-5 NOXO1 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 IGLV3-27 ELMO2 IGKC IGLV3-21 DOCK1 BAIAP2 CALM1 IGKV1-39 ABI2 IGKV1-33 V4-6 NOXA1 ABI1 IGHV3-53 JUN V4-2 PRKACG NOX1 IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK ELMO1 GNGT1 GNGT2 ACTB CYFIP2 WIPF1 WNT5A WIPF2 WIPF3 GNAT3 C3AR1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK MEFV PRKAR2B PLCG2 MYO5A ARPC1B ARPC1A VAV3 WASL CTSG PTK2 SYK GNAI3 ADCY4 WAS ADCY3 VAV2 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 NT5E GNG5 PYCARD GNG4 IGHG3 GNG7 IGHG4 GNG8 IGHG1 HSP90AB1 CYSLTR1 IL10 IGHG2 CYSLTR2 CD163 PLK2 GGT1 DPEP2 RHBDF2 DPEP1 MYH9 MYO9B ACTG1 GNAZ NCKIPSD DVL1 DVL2 DVL3 NLRP3 GGT5 FZD7 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 NCK1 FCGR3A ACTR3 ACTR2 FGR MYH2 GNG12 ADORA2B GNG11 FCGR1A GNG13 WASF3 MYO10 GNB2 P2RX7 P2RX4 TXNIP GNB1 FCGR2A GNAS MYO1C GNB4 SUGT1 GNB3 GNB5 FURIN ABL1 CASP1 IL18 IL1A IL1B GSDMD RELA NFKB1 AHCYL1 PRKACA ITPR1 ITPR2 ITPR3 PRKAR1A LYN YES1 TXN IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TBK1 IRF3 NLRP4 MRE11 DTX4 DDX41 PRKDC NLRC3 IFI16 XRCC6 XRCC5 TREX1 STING1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis F12 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors HCRTR2 QRFPR QRFP HCRTR1 NPFFR2 NPFFR1 HCRT NPFF NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly PPP2CA NUP62 RCC1 NUP43 BANF1 CHMP2B CHMP2A NDC1 NUP155 RAN NUP93 CCNB1 LMNB1 NUP35 NUP54 CDK1 TNPO1 SPAST CC2D1B SIRT2 TUBB8 IST1 NUP37 VRK1 LEMD2 TUBB8B UBE2I TUBB6 TUBB3 TUBB1 NUP107 SUMO1 PPP2R1A TUBA4B PPP2R2A TUBA4A NUP160 KPNB1 CCNB2 TUBA8 NUP85 TUBA1C TUBA1B TUBA1A LBR TUBB2B AHCTF1 TUBB2A SEC13 ANKLE2 NUP133 TUBAL3 TUBA3E VPS4A RANGAP1 TUBA3D TUBA3C CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 EMD CHMP7 TUBB4B TUBB4A NUP205 LEMD3 POM121 NUP188 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC3H APOBEC4 A1CF ADAR APOBEC3A APOBEC3B ADARB1 APOBEC1 APOBEC3C APOBEC2 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD ABCA1 APOA1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) MSH2 MSH3 PMS2 MLH1 PCNA LIG1 POLD3 POLD4 EXO1 POLD1 POLD2 RPA1 RPA2 RPA3 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception CHRNA9 LRP2 CLPS PNLIP APOA2 APOA4 LPL LDLR GPIHBP1 OPN1MW APOC3 APOC2 GNAT3 ADCY3 HSPG2 SDC4 SDC2 SDC3 MYH9 SDC1 MYO1C FNTA FNTB KCNMB1 KCNMA1 CHRNA10 KCNN2 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 USH1C ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 CASK GSN WHRN LHFPL5 OTOGL TMIE USH1G STRC EPB41L1 MYO15A SLC26A5 GNAL KCNJ2 AKR1C1 AKR1C4 SLC24A1 RHO SAG CNGA1 GNAT1 CNGB1 AKR1C3 PRKCA DHRS3 PLCB2 PDE6B DHRS9 PDE6A RDH11 PDE6G RDH10 RDH16 RDH5 OR11H2 OR11H1 OR2M7 OR11H4 SCNN1G OR2M5 SCNN1D OR2M4 SCNN1B OR2M3 SCNN1A OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 LRAT OR11H7 TRPM5 OR2L8 OR2L5 OR11G2 TRPM4 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 RBP4 RBP2 OR4K15 RBP3 OR4K14 OR4K13 RBP1 RETSAT OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 ANO2 OR5M10 RDH12 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 CNGA2 OR10J3 OR10J5 CNGA4 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 APOE OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 GUCA1B GUCA1A GUCA1C OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 PRKCQ OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 NMT2 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 PPEF1 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OPN1SW OR1Q1 OR51S1 OR4A47 STRA6 OR5B21 OR1P1 REEP1 OR13A1 APOB OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 RLBP1 OR56B1 OR2Y1 OR8D4 OR8D2 APOA1 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 LDB1 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 NMT1 OR10A5 LRP1 CALM1 OR6C65 LRP8 OR8B8 OR2W3 AWAT2 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 BCO2 OR12D2 BCO1 OR5AU1 RCVRN OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 METAP1 METAP2 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 GNGT1 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 OR52M1 ABCA4 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 PLB1 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 EBF1 OR52L1 APOM OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 RPE65 AKR1B10 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 TWF1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 LHX2 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 GNG13 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 GNB1 OR4A16 OR3A1 OR8K5 GNB3 OR8K3 GUCY2D OR8K1 HSD17B6 GUCY2F HSD17B1 OR4C45 SCN9A OR5AN1 OR4B1 SCN1B OR4C46 OPN1LW OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 EZR OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 SCN3A OR5K2 SPTBN1 OR51D1 OR5K1 OR6M1 RDX SDR9C7 OR2T12 MSN OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 SCN2A OR2D2 SCN2B OR52E4 SNAP25 OR5J2 OR52E2 OR52E1 OR2W5P SPTAN1 CAMKMT OR5AC2 RGS9BP VAMP2 OR5AC1 STX1A OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 SCN4B OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 TAS2R20 OR5I1 OR52D1 OR9Q2 OR9Q1 TAS2R10 GRK1 TAS2R13 CALHM1 TAS2R14 OR2AK2 TAS2R16 GRK7 OR51B6 OR51B5 OR51B4 TAS2R40 OR2B6 TAS2R41 OR4F6 OR5H6 TAS2R43 OR4F5 OR2B3 OR4F4 TAS2R46 OR2B2 OR10K2 OR10K1 OR4F3 CACNA2D2 OR5H2 OR5H1 OR6J1 TAS2R30 CALHM3 TAS2R31 OR2AJ1 OR51A4 TAS2R38 OR2A7 TAS2R39 OR51A2 LRP10 OR2A5 OR2A4 LRP12 SYN1 OR51A7 OR2A2 OR52J3 RTP2 RAB3A OR51H1 RTP1 OR8U9 TAS2R50 OR8U8 OR1G1 OR2I1 OR4M2 CACNB2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 CYP4V2 OR51G2 OR51G1 OR52I2 DNAJC5 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 TAS2R7 OR2G3 OR1E2 OR2G2 OR1E1 TAS2R8 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 GRM4 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 TAS2R1 OR1D5 TAS2R3 OR1D4 TAS2R5 OR1D2 TAS2R4 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 TAS1R2 TAS1R1 TAS1R3 TTR PCLO CAPZB BSN SYP CABP2 CACNA1D CABP1 LRRC52 OTOF SLC17A8 CAPZA1 CAPZA2 ITPR3 GRM1 ATP2B1 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation PPARG MTA2 PPARA PPARGC1B MBD3 GATAD2B GATAD2A UCP1 PPARGC1A HNRNPU NCOA1 MTA1 HDAC1 PRDM16 HDAC2 ZNF423 MTA3 ELOVL3 CIDEA EBF2 BMP7 CHD4 RBBP4 CHD3 COX7A1 RBBP7 SMAD1 SMAD4 RXRA NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway ESRRB ESRRG ESR2 RARA PGR NR4A1 PPARG PPARA RXRB PPARD THRA RXRG NR2E1 NCOR2 NR2F1 RARB NR0B2 NRBP1 NR2F6 NR2C2 NR2C2AP MED1 THRB NR1D1 VDR NR1D2 NCOR1 NR1H2 RORA RORC RORB NR2C1 ESR1 HNF4G NR5A1 NR4A2 ESRRA AR RXRA RARG HNF4A ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) TBK1 IRF3 UBA52 IRF7 TICAM2 TICAM1 TANK TLR4 LY96 TRAF3 UBB CD14 IKBKE OPTN UBC PTPN11 RPS27A VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis ACACA SCD ACSL1 HACD1 TECR HSD17B3 SLC27A2 HSD17B12 HACD3 HACD2 HSD17B8 HACD4 HTD2 FASN MORC2 CBR4 ELOVL1 ELOVL5 OLAH ELOVL4 ELOVL2 ACSL6 ACSL5 ELOVL3 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY PPT1 ELOVL6 ACSBG1 PPT2 SLC27A3 ACSBG2 SCD5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 RAD51B RAD51D ATM RAD51C DNA2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 KAT5 WRN EXO1 BRIP1 NBN RBBP8 BARD1 XRCC2 RMI2 PALB2 RAD50 RAD51 RMI1 TOP3A ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI PLA2G2A PLA2G4F PLA2G4E PLA2G10 PLA2G4C PLAAT3 PLA2R1 PLA2G1B PLA2G5 PLBD1 PLA2G4A MBOAT7 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 UBE2D1 PSMD12 ELOB PSMD11 PSMD14 ELOC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CITED2 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 VHL UBE2D2 HIF3A LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP VEGFA EPO CA9 HIGD1A EP300 ARNT CUL2 EPAS1 HIF1A CREBBP UBE2D3 PSMD8 PSMD6 AJUBA PSMD7 PSMD2 PSMD3 PSMD1 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling CHUK FBXW11 PSMA5 PSMA6 PSMA3 UBE2M PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 NFKB2 PSMA7 PSMB6 PSMB7 PSMB4 MAP3K14 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RELB SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 UBA3 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited CASP8 TNFRSF10B TNFRSF10A TNFSF10 FAS FASLG TRAF2 RIPK1 FADD TRADD RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP24 ARHGAP23 ARHGAP31 ARHGAP30 TFRC ARAP1 VAV1 SCFD1 ATP6AP1 TIAM1 HMOX2 RASGRF2 ARHGEF18 RTKN SOWAHC RHOA ARHGEF10L STK10 AKAP13 SLK LBR ARHGEF11 PGRMC2 ARHGEF10 ARHGEF12 ARHGEF17 STARD8 SNAP23 FLOT1 CIT DAAM1 ARHGAP6 ARHGEF3 FLOT2 ARHGEF1 ARHGEF2 ARHGAP42 PKN3 TRIO ARHGEF25 ARHGEF28 IQGAP3 ARHGAP1 STOM FMNL3 RHPN2 ARHGAP5 ARAP2 ARHGAP35 ECT2 PREX1 STARD13 ARAP3 OPHN1 JUP ARHGDIA CAVIN1 BCR STBD1 PCDH7 MCF2L MYO9A ARHGDIB NET1 ANLN TMPO DIAPH1 ABR PLEKHG3 ACTC1 RACGAP1 DLC1 PKN2 PKN1 DEPDC1B ARHGEF40 ARHGEF15 ARHGAP26 PLEKHG5 DOCK2 ARHGEF19 ARHGEF5 OBSCN ARHGEF4 VAMP3 ARHGEF7 NGEF PLD1 C1QBP KALRN ARHGAP39 ARHGAP21 LMAN1 STX5 YKT6 SRGAP1 MCF2 MCAM ERBIN KTN1 VANGL1 ARHGAP32 DIAPH3 VAPB ABCD3 TJP2 CAV1 ARHGAP9 ARHGAP8 ARHGAP4 GMIP VAV3 FARP1 DEF6 VMA22 VAV2 FAM13A TEX2 DDRGK1 ARHGAP11A ARHGAP11B ROCK1 TAGAP ROCK2 PLEKHG4 PLEKHG6 ARHGAP10 MYO9B TMEM87A PIK3R2 IQGAP1 PIK3R1 FAF2 EMC3 ARHGAP44 ARHGAP40 BCAP31 PREX2 ARHGAP45 ARHGAP19 ARHGAP18 AAAS SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants SOS1 EREG BTC SHC1 NRG2 HBEGF NRG3 EGFR NRG4 NRAS HSP90AA1 CDC37 HRAS ERBIN PLCG1 EGF ERBB2 NRG1 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels OPRK1 FKBP5 GPRIN1 MET PTPN4 HDAC1 SLC2A3 HDAC2 OPRM1 TRPC3 GRIN2B GRIN2A PTPN1 SIN3A GRIA2 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB TRIB3 PDPK1 AKT2 THEM4 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs PDGFRA SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol ISYNA1 INPP1 INPP5A IMPA1 IMPA2 INPP5B INPP4A INPP4B INPP5J OCRL MTMR9 SYNJ1 MTMR7 MIOX REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP SERPINA1 LAMB2 FN1 F5 LAMB1 LAMC1 MEN1 IGFBP1 IL6 GPC3 IGFBP3 VCAN PDIA6 VGF APOE WFS1 FSTL1 CP CHRDL1 TF ADAM10 MBTPS1 PENK SPP1 CDH2 BMP4 FGF23 C3 APOB C4A APOA1 PNPLA2 DNAJC3 CKAP4 PCSK9 APP CSF1 APOA2 TGOLN2 APOA5 KLK3 KTN1 KLK2 CALU SERPINC1 MFGE8 MMP1 CST3 GAS6 ALB QSOX1 PRKCSH AHSG P4HB F2 PROC TNC SPP2 TIMP1 DMP1 LGALS1 EVA1A CCN1 APLP2 FBN1 CTSG CHGB IGFBP5 IGFBP4 SCG3 IGFBP2 MGAT4A SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 SDC2 STC2 IGFBP6 KNG1 AMELX AMBN LTBP1 TMEM132A FUCA2 IGF2 IGF1 BPIFB2 PLG HRC MELTF HSP90B1 SERPINA10 MIA3 MSLN PRSS23 BMP15 MEPE RCN1 ENAM GZMH AMTN FAM20C VWA1 FAM20A MATN3 PAPPA2 ITIH2 AFP FSTL3 APOL1 FGA SERPIND1 GOLM1 KLK13 FGG NUCB1 NOTUM IGFBP7 ANO8 MMP2 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex PPIE COPS3 COPS6 COPS8 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 COPS5 MNAT1 AQR ERCC8 PRPF19 ISY1 GPS1 COPS4 COPS2 ZNF830 UVSSA XPA COPS7B COPS7A ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication H2AC6 H2AC7 H2AX KPNA1 H3-3B KPNB1 H2AC19 ORC5 H2AC14 H3C8 ORC4 H2BC12L ORC6 ORC1 H2AJ ORC3 KPNA6 ORC2 H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 H2AB1 H2AZ2 H2AC20 H2AC8 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB PPP2R1B PPP2R1A RB1 E2F1 PRIM2 PRIM1 POLA1 POLA2 PPP2R3B TFDP1 TFDP2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT DKK1 TNKS2 DKK2 DKK4 RNF146 PYGO1 H2AX PYGO2 SFRP1 SFRP2 ASH2L AMER1 CSNK1G2 CUL3 BCL9L BCL9 CCDC88C MEN1 CHD8 USP34 CBY1 RSPO2 SOST RSPO1 RSPO4 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 CXXC4 LRP6 ZNRF3 WIF1 H2AJ SRY RYK LGR6 LGR5 LGR4 PIP5K1B CTNNB1 H3C15 H2BC9 H3-4 H2BC8 APC H2BC5 H2BC3 SMARCA4 H2BC1 H2AB1 TLE1 H2AC8 H2AC6 H2AC7 PPP2R1B PPP2R1A TCF7 CSNK1E CSNK1A1 TERT GSK3B DPY30 XPO1 H2BC26 H2BC21 CTBP1 WDR5 EP300 PPP2R5E H2BC17 H2BC12 H2BC13 H2BC14 PPP2R5B H2BC15 PPP2R5A CREBBP PPP2R5D PPP2R5C H2BC11 RUVBL1 LEF1 PSMD8 RBBP5 PSMD6 PSMD7 PSMD2 PSMD3 XIAP TCF7L2 PSMD1 H2AZ2 TCF7L1 BTRC PPP2CA AXIN2 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 CDC73 RUNX3 PSMD13 PSMA7 PSMB6 PSMB7 SOX9 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC LEO1 PSMB1 RPS27A ADRM1 SEM1 RBX1 YWHAZ PSMC5 PSMC6 PSMC3 KMT2B PSMC4 PSMC1 PSMC2 HDAC1 TLE4 TLE2 KLHL12 WNT5A HECW1 CAV1 WNT9A SMURF2 RSPO3 KAT5 WNT8A WNT8B AXIN1 H2AC19 H2AC14 H2BC12L AKT2 SOX2 MYC AKT1 WNT1 SOX17 CSNK2A1 WNT3 CSNK2A2 WNT4 USP8 FZD1 CSNK2B DVL1 FZD2 DVL2 FZD5 DVL3 FZD4 WNT3A TLE3 FZD6 FZD8 H4C9 TRRAP SOX3 FRAT1 FRAT2 SOX6 SOX7 SOX4 H2AC20 RNF43 CTNNBIP1 SOX13 TNKS SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells PLCG2 SOS1 KRAS UBA52 INPPL1 IL34 CSF1 INPP5D UBB PIK3CD SRC PIK3CB UBC RPS27A CBL GAB3 HCK GAB2 CSF1R PIK3R1 PIK3CA SHC1 STAT1 LYN STAT3 YES1 THOC5 FYN GRAP2 PTPN11 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling SIPA1 YWHAZ RAP1GAP PRKACA PRKACG RAP1B PRKACB YWHAB RASGRP2 RAP1A RAF1 RAPGEF3 RAPGEF4 RASGRP1 RAP1GAP2 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DPH3 EEF2 DPH5 DPH6 DPH7 DNAJC24 DPH1 DPH2 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching SLIT1 ROBO1 ROBO2 NCK2 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway PRKCB ELMO2 DOCK1 BAIAP2 CALM1 ABI2 RASA1 ABI1 PRKACG PRKACB RAC1 VAV1 CTNND1 SHB CTNNB1 SH2D2A KDR PAK1 NOS3 ELMO1 RICTOR PAK3 SHC2 PAK2 NRAS AXL HRAS PTK2B CYFIP2 PLCG1 CAV1 CDH5 MAPK14 AHCYL1 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 PRKACA VAV3 CRK ITGAV PTK2 THEM4 PRKCD PRKCA VAV2 HSPB1 ITPR1 PXN ITPR2 PRR5 AKT2 ITPR3 PRKCZ AKT3 RHOA PIK3CB AKT1 ROCK1 ROCK2 MLST8 SPHK1 BCAR1 NCKAP1 NCF1 NCF2 TRIB3 NCF4 PDPK1 ITGB3 BRK1 CYFIP1 MAPKAP1 PIK3R2 PIK3CA PIK3R1 NCK2 CTNNA1 NCK1 CYBB HSP90AA1 JUP CYBA CDC42 WASF3 FYN NCKAP1L WASF1 MTOR WASF2 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex BCL7A BCL7C BICRAL BICRA BCL7B BRD9 SS18 SS18L1 SMARCD1 SMARCD2 SMARCA2 ACTB SMARCA4 SMARCC1 SMARCD3 SMARCC2 ACTL6A MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK BACH1 NFE2L2 HM13 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism ALDOB ALDH1A1 TKFC GLYCTK KHK MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation HLA-DRB3 HLA-DRB1 CTSC AP1G1 ACTR1A AP1S2 AP1B1 AP1S1 AP1S3 HLA-DPA1 AP1M2 AP1M1 SPTBN2 CTSA HLA-DQB2 KIF4B HLA-DQB1 KIF4A SEC31A SH3GL2 HLA-DOA HLA-DOB LAG3 KIF20A KLC1 DNM1 KLC4 DNM3 KLC3 DCTN1 KLC2 OSBPL1A KIF11 KIF15 CTSO ARF1 ACTR1B CTSH CTSF HLA-DPB1 CTSE KIF23 KIF22 HLA-DMA CTSV SEC23A HLA-DMB RILP CTSL CD74 SAR1B CTSK KIF26A DNM2 DCTN2 DCTN3 SEC24B DYNC1LI1 SEC24A DYNC1LI2 SEC24D HLA-DRA SEC24C IFI30 KIF18A SEC13 CLTC CLTA DYNLL1 DYNLL2 KIF2A KIF2C CANX KIF2B RACGAP1 DYNC1I2 AP2A1 RAB7A AP2A2 DYNC1I1 DYNC1H1 AP2M1 CENPE DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 AP2S1 AP2B1 CAPZB CAPZA1 CAPZA2 KIF5C KIF5B KIF5A KIFAP3 CTSS LGMN CTSB KIF3B KIF3A KIF3C HLA-DQA2 HLA-DRB5 CTSD HLA-DRB4 REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes LEF1 TCF7 TCF7L2 HDAC1 TLE1 TLE3 TCF7L1 TLE4 TLE2 CTBP2 TLE5 CTBP1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism FADS1 SCP2 ACSL1 ELOVL1 ELOVL5 ACOT8 ELOVL2 HSD17B4 ACAA1 ELOVL3 ABCD1 FADS2 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 KPNA1 NUP214 NDC1 NUP210 NUP155 HMGA1 AP1G1 NUP153 RAC1 PACS1 AP1S2 NUP93 AP1B1 NUP50 AP1S1 NUP35 AP1S3 NUP54 HLA-A SLC25A5 B2M SLC25A4 AP1M2 SLC25A6 AP1M1 PAK2 ATP6V1H ARF1 NUP107 NPM1 NUP160 KPNB1 NUP85 XPO1 SEC13 NUP133 LCK RANGAP1 PSMD8 PSMD6 FYN PSMD7 PSMD2 PSMD3 PSMD1 PPIA BTRC SKP1 CD4 RCC1 DOCK2 NUP43 PSMA5 AP2A1 PSMA6 PSMA3 RANBP1 AP2A2 PSMA4 PSMA1 CCNT1 PSMA2 RANBP2 UBA52 PSMD12 RAN PSMD11 ELOB AP2M1 PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NUP37 ADRM1 SEM1 RBX1 HCK PSMC5 CD8B PSMC6 ELMO1 PSMC3 CDK9 AP2S1 PSMC4 PSMC1 PSMC2 AP2B1 CUL5 NUP205 POM121 NUP188 PSIP1 AAAS CD28 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins ALOX5 ALOX15 HPGD LTA4H RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants SPRED3 SPRED2 SPRED1 HRAS NF1 NRAS EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF4EBP1 EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 EIF5 RPS13 EIF5B RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 EIF2B5 RPL15 EIF2B4 RPS2 EIF2B3 RPL18 EIF2S3 RPL17 EIF2B2 EIF2B1 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 HSPA1A NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 XPO1 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors GRIP2 GRIA1 PRKCB AP2A1 EPB41L1 TSPAN7 GRIA3 GRIA4 PRKCA MDM2 CAMK2B CAMK2D CAMK2A DLG1 DLG4 GRIA2 AKAP5 CAMK2G PICK1 CACNG8 MYO6 CACNG2 CACNG3 CACNG4 GRIP1 NSF PRKCG DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor VWF F8 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease RPIA TALDO1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state MCM6 MCM2 PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 ORC5 PSMB7 ANAPC5 ORC4 PSMB4 ANAPC1 ORC6 PSMB5 ANAPC2 ORC1 UBB MCM8 GMNN PSMB2 CCNA2 PSMB3 ORC3 CCNA1 ORC2 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 SKP2 CCNE2 CCNE1 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 MCM7 PSMD3 PSMD1 MCM3 MCM4 SKP1 MCM5 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM2 SEL1L AMFR RNF103 UBA52 TRIM13 MAN1B1 RNF185 UBB UBC RPS27A DERL2 CALR OS9 SYVN1 PDIA3 RNF5 PRKCSH EDEM1 CANX GANAB DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA EGF AREG MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2I POLR2J PRKRA POLR2K DICER1 POLR2L TARBP2 BCDIN3D RAN XPO5 DROSHA POLR2A POLR2B AGO3 POLR2C DGCR8 AGO4 POLR2D POLR2E AGO1 POLR2F AGO2 POLR2G POLR2H NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 NTRK2 RAC1 DOCK3 BDNF ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry TMPRSS2 ACE2 VCP CTSL DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema F12 SERPING1 KLKB1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription EZH2 H2AX PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 H3-3B TEAD4 H3C8 FOS H2AJ YAP1 H3C15 RICTOR SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 PRR5 INTS12 GSK3B INTS13 INTS14 DPY30 INTS10 ICE1 ICE2 H2BC26 SSU72 H2BC21 NABP2 MLST8 NABP1 WDR5 YWHAG ELL2 EED ELL3 PDPK1 ZC3H8 H2BC17 RPRD2 RPAP2 H2BC12 RPRD1B H2BC13 RPRD1A H2BC14 POU2F2 H2BC15 H2BC11 PRKAA1 PRKAA2 LEF1 RBBP4 RBBP5 RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C TNRC6A TNRC6B CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TP53 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 PAPOLA SYMPK CPSF4 TGFB1 PARP1 PABPN1 CDC73 BLK ELF1 ELF2 CBFB PAX5 SKIC8 RUNX1 CTR9 RTF1 LEO1 PAF1 SOX2 ZNF521 TRPC3 PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA CPSF7 FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYA NFYB NFYC GPAM SP1 CASP1 TP63 TNFRSF10B TNFRSF10A ITCH FAS CYCS BAX STUB1 PRKACA CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM2 MDM4 BMI1 VENTX RING1 CCNA2 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PHAX SNRPD3 PRMT5 SNRPG SNRPE SNRPF SNRPB PHF20 CHEK2 ZNF385A PCBP4 SRRT GRIN2A CAMK4 PLK2 MDC1 SPI1 MT-CO1 RBPJ NOC2L ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 SCO2 ZNF705EP DDIT3 DDIT4 TXNIP MT-CO2 MT-CO3 MYL9 ZNF28 ZNF274 ZNF273 MEAF6 ZNF20 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 ZNF26 SFN ZNF268 PPARGC1B ZNF267 PRELID3A ZNF266 ZNF264 ZNF263 ABCA6 NR2F1 ZNF34 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 BBC3 MED12 MED14 MED13 HEY1 CASP10 MED10 ZNF41 HEY2 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 CNOT6L ACTL6B ZNF480 ACTL6A MED27 MED26 SIRT3 DDB2 MED23 MED25 MED24 MMP13 MED20 ZNF479 ZNF235 ZNF234 ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT EGFR BGLAP PLAGL1 SPP1 ZNF227 ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 USP9X ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 UBE2D3 PSMD8 RORC RORB PSMD6 YY1 PSMD7 SESN3 PSMD2 ZNF208 PSMD3 SESN2 PSMD1 ZNF205 ZNF689 KMT5A ZNF688 ZNF446 SKP1 ZNF445 PITX2 PRKCB ZNF202 PSMA5 ZNF443 PSMA6 ZNF200 PSMA3 ZNF684 PSMA4 ZNF442 PSMA1 ZNF441 PSMA2 BNIP3L ZNF682 UBA52 ZNF440 ZNF681 PSMD12 ZNF680 PSMD11 AFF4 ZFP69B MLLT1 PSMD14 FOXP3 MLLT3 PSMD13 NPAS4 SUPT6H CUL1 MAF IWS1 PSMA7 ZNF439 EAF1 ZNF679 EAF2 RELA ZNF678 PSMB6 ZNF436 PSMB7 ZNF677 PSMB4 ZNF676 PSMB5 ZNF433 ZNF675 UBB PSMB2 ZNF432 PSMB3 PVALB ZNF431 UBC PSMB1 ZNF430 RPS27A GRIA2 KMT2D ADRM1 ZNF671 NFKB1 ZNF670 SEM1 CPAP PSMC5 MAX PSMC6 DLX5 PSMC3 DLX6 PSMC4 KMT2B PSMC1 FOXO6 PSMC2 FOXO4 FOXO1 ZNF840P ATXN3 SOCS3 MED30 MOBP ZKSCAN7 HDAC4 ZNF429 MED31 THRB ZKSCAN8 UBE2I ZKSCAN3 VDR SMYD2 NR1H2 RORA ZNF669 ZNF668 NR3C1 ZNF426 NR2C1 ZNF667 ESR1 ZKSCAN5 ZNF425 ZKSCAN4 NR5A1 ZNF665 NR4A2 AR ZNF664 ZKSCAN1 RXRA SOCS4 SUMO1 BCL2L14 ZNF662 ZNF420 RARA ZNF660 PGR PPARG BRPF1 PPARA BRPF3 TNFRSF10C FBXO32 MRE11 G6PC1 BRCA1 TNFRSF10D RGCC ZNF419 KAT5 ZNF418 EXO1 ZNF417 ZNF658 ZNF416 CHEK1 ZNF415 NBN PIN1 TOPBP1 ZNF655 SP7 PPP1R13B COX4I1 COX4I2 RFC5 PTEN RFC3 RMI2 ITGAL PPP1R13L RFC4 ZNF649 DGCR8 YAF2 RFC2 RMI1 NKX3-2 ZNF641 TOP3A TRIM63 HUS1 APAF1 ITGA4 TNFRSF18 RAD51D ARNT RABGGTB DNA2 RABGGTA RHNO1 BLM RRM2B HAND2 ZNF875 PCNA ITGA5 SRF PPM1D WRN ZNF627 ZNF626 BRIP1 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 RBBP8 ATRIP E2F5 ZNF620 BARD1 E2F6 E2F7 E2F8 RPA1 ZNF860 RPA2 PTPN1 MGA TBX5 RAD50 PINK1 RAD51 ZNF619 RPA3 SST IL2RA ZNF616 RAD17 SYT10 RAD1 ZNF615 ATM ZNF614 RAD9B ZNF613 ATR ZNF611 RAD9A PTPN4 ANAPC15 ZNF610 ANAPC16 ANAPC7 TRIM33 SMARCB1 UBE2C CCNC UBE2E1 UXT UBE2D1 LGALS3 ZNF729 ANAPC10 TRIM28 ANAPC11 ZNF727 CCNB1 CDC23 ZNF726 ZNF724 UBE2S CDC26 EPC1 CDC27 CCN2 ZNF721 CDC16 SMARCC1 CDK1 ANAPC4 SMARCC2 ANAPC5 ZFP1 ANAPC1 ZFP2 ANAPC2 ZNF718 ZNF717 ZNF716 SRC ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 ZNF324B CTNNB1 L3MBTL2 FOXG1 MET TGFA ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 YWHAB APOE PCK1 CRADD IQSEC3 MAPK1 SMARCA2 SMARCA4 SNW1 MAPK3 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C MAPK14 CTSL CTSK HNF4A COX8A MAPK11 SREBF1 COX8C PBRM1 SATB2 COX5B COX5A RXRB ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 COX6C GCK ATF2 VEGFA TTC5 CCNG2 CCNG1 HDAC3 MAMLD1 ZFP28 SMARCD3 PRDM7 PRDM1 COX6A1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 XPO1 COX6B2 GEM COX6B1 ZNF92 EP300 GPRIN1 NDRG1 TBL1X HIGD1C IRAK1 TFAP2A PPARGC1A TFAP2B ZFHX3 TFAP2C MED1 TFAP2D CREBBP AUTS2 MEF2C TFAP2E CNOT10 IL2 IL3 BMP2 NR1D1 SIRT1 CNOT11 TCF3 NCOR1 DYRK2 TBL1XR1 LDB1 CARM1 CHD4 CHD3 TRIAP1 BMAL1 PIDD1 YWHAQ MYBL2 TGIF1 ZNF75CP RBM14 TGIF2 CAT TMEM219 RETN NFATC2 AURKA INS CALM1 MTA2 RRM2 YWHAE ZNF804B REST JUN KRAS FASLG ZNF175 SOD2 MAML2 CDC25C MAML1 FOXO3 SERPINE1 GLS NAMPT ZSCAN32 MYB PIP4K2A PRDX2 BCL2L11 PIP4K2B JUNB CDK5 ZNF169 RNF111 GAMT PRDX1 ZNF705G ZNF705D ZNF160 CDK5R1 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 NOTCH1 RBX1 ZNF155 ZNF154 ZNF394 NEDD4L NKX2-5 NR2C2AP NFE2 IHH PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 SETD1B SETD1A CDC7 NR1D2 ZNF37A ZNF702P ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET GPI BTG2 RARG BTG1 SETD9 CRH CHM GLI3 GLI2 ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 RSPO3 ZNF124 ZIK1 BRD2 BRD1 TCF12 NCOR2 KAT2B KAT2A SNAPC5 TAL1 SNAPC1 RARB SNAPC2 ZNF599 SNAPC3 ZNF114 SNAPC4 ZNF143 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 GPS2 ZNF589 ZNF347 BRD7 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 WWOX ZNF582 PCGF6 TIGAR PCGF5 PCGF2 WWP1 HIPK1 POU2F1 POU4F1 POU4F2 ZNF33B HIPK2 ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 ITGA2B YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 MEN1 ZNF563 IGFBP1 ZNF562 GAD1 ZNF320 GAD2 ZNF561 USP7 ZNF560 IGFBP3 USP2 NRBP1 KAT6A ZNF559 ZNF317 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 NOTCH2 ZNF793 ZNF551 CSF1R RB1 ZNF792 CDKN1A NOTCH3 CDKN1B ZNF550 CCND3 ZNF791 ZNF790 FZR1 CCND2 NOTCH4 CCND1 ZNF767P E2F1 ZNF549 ZNF548 ABL1 ZNF547 SKP2 DAXX ZNF546 ZNF304 ZNF544 CDK6 ZNF786 TFDP1 CCNE2 ZNF302 ZNF785 TFDP2 LSM10 ZNF543 CDK4 SLBP CCNE1 SKIL LSM11 ZNF300 CDK2 PLXNA4 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC PPP2R1B CNOT4 PPP2R1A CDK8 ZFP69 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 ZNF774 CNOT9 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 SIN3A ZNF528 ZNF764 LBR ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 HDAC2 SMARCD2 PPP2R5C RNF34 GLS2 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 BIRC5 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 AURKB KCNIP3 KLF4 PML ZNF738 PPP2CA ZNF737 PPP2CB ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 TP53AIP1 ZNF607 ZNF606 ZNF605 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 CITED1 CITED2 CITED4 PRMT6 KRABD5 KRABD4 PRMT1 MSH2 KRABD3 GP1BA PMS2 SGK1 ZNF2 MLH1 ZNF3 NPY ARNT2 ZNF354A ZNF354C ZNF354B STEAP3 LMO1 LMO2 TJP1 KCTD1 OCLN ATP1B4 LIFR KCTD6 FANCD2 COXFA4 NOP2 COX7A2 CCNH COX7A1 RNMT PMAIP1 POLR2A SMAD2 POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E CBX5 POLR2F SMURF2 POLR2G CBX3 POLR2H SMURF1 POLR2I SMAD6 POLR2J ESR2 POLR2K SMAD7 POLR2L NR4A1 RNGTT TP53I3 GTF2H1 NR4A3 GTF2H2 JMY SUPT5H KDM5B GTF2H3 THRA GTF2F1 CGB8 GTF2F2 SLC2A3 GTF2H4 NR2E1 GTF2H5 YBX1 CDK7 CASP6 ERCC3 CASP2 ERCC2 AXIN1 MNAT1 OPRM1 ARID1A ARID1B RBL2 H2AC19 RBL1 H2AC14 IFNG H2BC12L ZNF197 AKT2 ZNF195 MYC NR2C2 AKT3 THBS1 HSPD1 AKT1 ERBB2 HES1 PRKAB2 ZNF189 CSNK2A1 ZNF286A CSNK2A2 ZNF184 PRKAB1 ZNF180 CSNK2B OPRK1 ARID3A DEK MAPKAP1 WWTR1 YES1 H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly HSPA9 UQCRB UQCC3 UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH LYRM4 UQCRQ LYRM7 UQCRC1 LETM1 UQCRFS1 UQCRC2 CYC1 MT-CYB FXN VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation PRKCB PDPK1 KDR CALM1 RASA1 PRKCD PRKCA NRAS HRAS ITPR1 ITPR2 PLCG1 ITPR3 PRKCZ AHCYL1 SPHK1 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR CXCL8 VAV1 PAK1 MAPK7 TIAM1 DGKG DGKE C5AR2 DAGLA C5AR1 DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI DGKH RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 GRK3 ARHGEF10L PIK3CG AKAP13 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 RHOB PDPK1 C3 C5 ARHGEF3 ARHGEF1 ARHGEF2 PIK3CA ARHGEF25 ECT2 CDC42 NET1 ABR ADRA1D ADRA1B ADRA1A GPR176 ARHGEF40 GPR15 PLEKHG2 GPR27 ARHGEF15 GPR25 PLEKHG5 GPR20 ARHGEF19 GPR32 RHOC GPR45 TIAM2 GPR150 OBSCN GPR83 ARHGEF4 GPR84 ARHGEF7 PRKACG NGEF PDE2A PPP1R1B ARHGEF6 FGD1 PDE3A PRKACB FGD2 CCL4L2 RGS8 GNA13 FGD3 PDE8B FGD4 PDE8A TBXA2R PCP2 GRK6 GNA12 ARHGEF33 GPSM1 ARHGEF35 GPSM2 ARHGEF37 PDE4A ARHGEF39 GPSM3 ARHGEF38 PDE4D PLXNB1 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 PDE7B PDE7A OPN1MW CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P GNAT3 HRH1 HTR6 C3AR1 HTR7 RGS9 RGS6 HRH3 ADCY9 RGS7 HRH2 PRKAR1B HRH4 DRD1 BTK DRD2 PRKAR2B DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D GNAI3 ADCY4 HTR1A TAAR5 ADCY3 HTR1B TAAR2 PRKX ADCY2 HTR5A TAAR1 ADCY1 ADCY8 GPR143 GNAQ ADCY7 ADRB3 ADCY6 GNAI1 ADCY5 GNAI2 CAMK4 CYSLTR1 CYSLTR2 GNAZ GNA14 GNA15 GNA11 ADORA2B RGS11 S1PR1 PLCB4 PRKCG KPNA2 GNAL NBEA EGFR RASGRF2 ARHGEF9 CAMKK1 CAMKK2 GABBR2 GABBR1 PRKCB RHO GNAT1 SAA1 GNAT2 PRKCA PLCB3 PLCB1 PLCB2 PRKAR1A PPP3CC MCHR1 ITGA5 TRPC7 TRPC6 TRPC3 SST CCL2 SRC NRAS SSTR3 MAPK1 HRAS MAPK3 PRKCQ SOS1 RASGRP2 ARHGEF18 RHOA OPN1SW ITGB1 TRIO ITSN1 PREX1 MCF2L ARHGEF16 PPP3CA PPP3CB RASGRP1 PPP3R1 CALM1 CCR5 ARHGEF5 APP ARHGEF26 KALRN MC4R EDNRB CDK5 MCF2 RPS6KA1 EDN1 EDN3 GLP1R UCN VIPR1 MC3R VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP PPP1CA ADGRE2 POMC SHH GNGT2 MC1R ADGRE5 UCN3 UCN2 MC5R ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP MGLL ADCYAP1 SMO CRH IAPP ADCYAP1R1 CGA RAMP2 CALCA TSHB RAMP3 VAV3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 CX3CR1 VAV2 PTHLH CRHR1 GHRHR WNT6 GNG10 PRKAR2A GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 ROCK1 CXCR4 WNT2 ROCK2 CD55 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 FZD4 CXCL12 WNT3A PTCH1 FZD7 GCGR WNT7B FZD6 PTCH2 FZD9 SCTR FZD8 WNT7A SOS2 GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH MRGPRD GNB1 CMKLR1 PF4 GNAS PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 VIP GALR3 RAMP1 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 CCL19 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 HBEGF ECE1 ECE2 ANXA1 PRLHR ADORA2A CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN TAS2R20 RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 KEL PPP2R1B TAS2R40 PPP2R1A TAS2R41 TAS2R42 TAS2R43 LHB TAS2R45 TAS2R46 NLN MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP ADRA2C TAS2R38 ADRA2B TAS2R39 ADRA2A TAS2R60 PTGDR2 CX3CL1 CCR9 PDE3B CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 PPP2R5D NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 PPP2CA TAS2R9 PPP2CB CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 RGSL1 GRM3 GRPR GRM2 EDNRA GRM4 PROK2 GRM7 PROK1 GRM6 UTS2R GPER1 NPFF GRM8 TRHR TAS2R1 UTS2B TAS2R3 AGTR1 TAS2R5 PTGFR TAS2R4 LPAR1 PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR TAS1R2 LPAR5 S1PR3 LPAR6 TAS1R1 NMS S1PR2 NMU S1PR5 GNRH2 TAS1R3 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY ACKR4 AVPR2 BRS3 ACKR3 GPRC6A OXT ACKR2 GPR132 AVP ACKR1 CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR AHCYL1 NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 PRKACA F2RL2 F2RL3 GPR68 PDE1C GPR65 PDE1B PDE1A PMCH RGS4 GRK2 PRKCD RGS5 RGS2 PLA2G4A RGS3 RGS1 GHSR OPRM1 CAMK2B CASR CAMK2D F2R CAMK2A LTB4R2 UTS2 ITPR1 NTS ITPR2 KNG1 AKT2 MCHR2 ITPR3 GRK5 AKT3 TAC3 TAC1 AKT1 CRHR2 OPN4 NMUR2 NMUR1 CAMK2G MLNR TRH LTB4R GRM1 OPRK1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 ARRB1 XCL2 PIK3R3 XCL1 PIK3R2 ARRB2 PIK3R1 RGS18 RGS17 PIK3R6 RGS19 PIK3R5 RGS13 RGS16 P2RY6 P2RY2 RPS6KA3 P2RY1 RPS6KA2 RGS21 CCK HCRTR2 HCRTR1 KISS1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD POMC MC2R ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) ACACA PMVK SC5D FDFT1 PPARA FDPS NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SMARCD3 CHD9 HELZ2 TGS1 TBL1X FASN NCOA1 MED1 NCOA2 CREBBP NCOA6 TM7SF2 GGPS1 HMGCS1 TBL1XR1 ELOVL6 CARM1 LSS SREBF2 MTF1 MVD IDI1 MVK RXRA ACACB NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects PNP NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 CHUK IFIH1 CASP8 RNF135 TRIM25 MAVS TRIM4 RIGI CASP10 IKBKB RIPK1 IKBKG FADD MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis H2AX ASH2L CCNC PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2C GPAM SCD ADIPOQ HDAC3 PHLDA1 ACSL1 PEX11A DPY30 H2BC26 H2BC21 CIDEC WDR5 EP300 TBL1X H2BC17 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 CREBBP NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 PDK4 ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL LIPE DGAT2 MED30 MED31 KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism PAPSS2 PAPSS1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 NNMT RPL23 RPS5 AHCY RPL22 RPS6 RPSA MAT1A RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 CBS RPL36A RPS27L RPS15A TXNRD1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A CTH RPL23A UBA52 RPL22L1 FAU RPL26L1 QARS1 RARS1 HNMT MARS1 RPS27A SEPHS2 SECISBP2 EEFSEC SEPSECS DARS1 PSTK LARS1 INMT SARS1 GNMT EEF1E1 SCLY KARS1 IARS1 AIMP1 AIMP2 EPRS1 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX5 ALOX15 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway DERA TKT RPIA PGD SHPK RBKS TALDO1 PRPS2 PRPS1 RPEL1 RPE PGM2 PGLS PRPS1L1 G6PD CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 SEL1L PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 RNF185 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 RNF5 ERLEC1 PSMD8 CFTR PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts SLCO1B1 NCOA1 SLCO1B3 BAAT NCOA2 STARD5 SLC10A1 SLC10A2 SLC51A SLC51B SLC27A5 NR1H4 ABCC3 ALB FABP6 ABCB11 SLCO1A2 RXRA SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability CALM1 VAV3 THEM4 RAC1 VAV2 PRR5 AKT2 VAV1 AKT3 AKT1 CTNND1 MLST8 CTNNB1 TRIB3 PAK1 PDPK1 NOS3 MAPKAP1 RICTOR PAK3 PAK2 CTNNA1 HSP90AA1 JUP CAV1 CDH5 MTOR DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling CHUK FBXW11 PSMA5 PSMA6 PSMA3 UBE2M PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 NFKB2 PSMA7 RELA PSMB6 PSMB7 PSMB4 MAP3K14 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RELB SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 UBA3 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle ARHGAP12 ARHGAP22 ARHGAP20 ARHGAP29 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 RAC1 ARHGAP31 ARHGAP30 DOCK6 DOCK9 TFRC ARAP1 ALS2 VAV1 FMNL1 LAMTOR1 PAK1 PAK3 PAK2 DOCK3 FARP2 PLD2 TIAM1 JAG1 SOS1 RASGRF2 ARHGEF18 PARD6A LBR ARHGEF11 ARHGEF10 NCKAP1 NCF1 NCF2 NCF4 DOCK8 SNAP23 CIT ITGB1 BRK1 CYFIP1 DOCK10 DOCK5 ARHGAP42 DOCK4 TRIO BAIAP2L1 ARHGEF25 PIK3CA CDC42BPA IQGAP3 ARHGAP1 GIT1 SWAP70 ARHGAP5 ARAP2 ARHGAP35 CYBB ECT2 PREX1 ARAP3 OPHN1 ARHGDIA CYBA BCR CDC42 MCF2L AMIGO2 ARHGDIB NOXO1 ARHGAP17 EMD TMPO ARHGAP15 ABR PLEKHG3 RACGAP1 DLC1 PKN2 VRK2 NHS PKN1 LEMD3 NCKAP1L DEPDC1B WASF1 WASF2 NISCH PLEKHG2 CDC42EP1 ARHGEF15 GIT2 ARHGAP26 DOCK2 ARHGEF19 DOCK1 BAIAP2 ARHGEF5 TAOK3 TIAM2 RAB7A ABI2 EPHA2 NOXA1 ARHGEF4 VAMP3 ABI1 NOX3 ARHGEF7 NGEF GARRE1 NOX1 FERMT2 ARHGEF6 PLD1 IQGAP2 KALRN GNA13 ARHGAP39 ARHGAP21 SRGAP3 SRGAP2 YKT6 SRGAP1 PAK4 MCF2 MCAM ARHGEF39 ERBIN SLC1A5 MPP7 DOCK7 KTN1 VANGL1 ARHGAP32 DIAPH3 ESYT1 CYFIP2 WIPF1 WIPF2 CAV1 WIPF3 ARHGAP9 ARHGAP4 GMIP CDC42EP4 VAV3 FGD5 WASL CHN2 CHN1 FARP1 DEF6 WAS VAV2 FAM13B FAM13A TAGAP PLEKHG4 PAK6 PLEKHG1 PAK5 PLEKHG6 ARHGAP10 MYO9B SH3BP1 ABL2 SPATA13 PIK3R3 PIK3R2 IQGAP1 PIK3R1 SOS2 SYDE2 WASF3 ARHGAP44 DOCK11 RALBP1 PREX2 ARHGAP45 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition CEP57 CETN2 PLK1 CEP164 ACTR1A CCNB1 PCM1 CNTRL CDK1 CEP290 NINL CCNA2 CCNA1 RAB8A OFD1 CDKN1A TUBB HAUS4 HAUS3 FZR1 HAUS6 HAUS5 TUBG1 FBXL18 HMMR HAUS2 HAUS1 CDK2 CEP63 NEK2 SFI1 SDCCAG8 PPP2R1B PPP2R1A DCTN2 SSNA1 SGO1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E PHLDA1 CCNB2 NEDD1 ALMS1 CEP41 CEP43 XPO1 YWHAG EP300 DYNLL1 HSP90AA1 CKAP5 PSMD8 RBBP4 PSMD6 MAPRE1 PSMD7 PSMD2 PAFAH1B1 PSMD3 MYBL2 DYNC1I2 PSMD1 BTRC SKP1 PPP2CA PPP2CB FBXW11 AURKA PSMA5 PSMA6 PSMA3 CLASP1 YWHAE PSMA4 PSMA1 PSMA2 UBA52 PPP1R12A DYNC1H1 GTSE1 CDC25C PSMD12 FKBPL PSMD11 NDE1 CDC25A PSMD14 CDC25B PSMD13 CENPF CUL1 PSMA7 HJURP MIS18BP1 PSMB6 PSMB7 PSMB4 PSMB5 UBB TPX2 PSMB2 OPTN PSMB3 TUBGCP2 UBC PSMB1 RPS27A TUBGCP5 ADRM1 TUBGCP6 SEM1 TUBGCP3 CPAP TUBGCP4 RBX1 PSMC5 TUBG2 PSMC6 FBXL7 MZT2B PSMC3 MZT2A PSMC4 NME7 PSMC1 PPP1CB LIN54 MZT1 PSMC2 LIN52 PKMYT1 LIN37 LIN9 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B CCNH TICRR FOXM1 AKAP9 PRKAR2B PPP2R2A TUBA4A PRKACA TP53 CDK7 CCP110 MNAT1 CEP250 CDK5RAP2 CEP135 CEP131 CSNK1D TUBA1A HSP90AB1 CEP70 CEP72 CEP192 CEP76 CEP78 PPP2R3B PLK4 AJUBA ODF2 TUBB4B TUBB4A SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs SNRPD3 NCBP1 SNRPG NCBP2 LSM10 SNRPE ZNF473 LSM11 SNRPF SNRPB RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins PLK1 RAC1 FMNL1 FMNL2 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 RHOA NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 RHOB SPDL1 DAAM1 ITGB1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 FMNL3 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP CDC42 BIRC5 KIF2C KIF2B DIAPH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 RHOC BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI SRGAP2 TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS DIAPH3 NUP37 SPC25 MRTFA ACTB SCAI PFN1 PFN2 ACTG1 DVL1 DVL2 DVL3 SRF RHOD EVL APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B CDC20 ANAPC15 ANAPC16 ANAPC7 UBE2C UBA52 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 UBB ANAPC2 UBC RPS27A METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors COQ6 ACO1 COQ5 GCHFR COQ4 HPDL CALM1 COQ3 COQ2 COQ8B COQ8A PRKG2 AKT1 NOS3 HSP90AA1 DHFR IDH1 PTS SPR PDSS2 PDSS1 GCH1 STARD7 COQ9 COQ7 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis GSK3A DUSP16 RAB7A KPNA1 CTSG UBA52 SFPQ B2M RAB5A KPNB1 VPS33B PGK1 CORO1A RNF213 UBB UBC RPS27A HGS TLR2 MRC1 MAPK1 ATP6V1H MAPK3 LTF NOS2 ENO1 TRIM27 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation AKAP9 KCNH2 KCNE1 KCNE2 KCNE3 KCNE4 KCNA5 KCNE5 KCNQ1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion PAK1 PLXNA2 CFL1 PLXNA3 FES PAK3 PAK2 SEMA3A RAC1 HSP90AA1 LIMK1 PLXNA1 NRP1 FYN PLXNA4 HSP90AB1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation FGF9 FGF20 FGF23 GALNT3 FGF16 FGF18 FGF1 FGF2 FGF4 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors H2AX PLK1 RAC1 H3-3B H3C8 H2AJ CDH1 CTNNB1 H3C15 PAK1 PAK3 PAK2 KLC1 H2BC9 KLC4 H2BC8 KLC3 YWHAB H2BC5 KLC2 H2BC3 MAPK1 H2BC1 MAPK3 H2AB1 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 PRKCZ RTKN RHOA XPO1 H2BC26 H2BC21 NCKAP1 NCF1 YWHAG NCF2 RHOB NCF4 PDPK1 CIT H2BC17 DAAM1 ITGB1 BRK1 CYFIP1 H2BC12 H2BC13 H2BC14 PKN3 H2BC15 NCOA2 IQGAP3 RHPN2 H2BC11 CYBB CYBA CDC42 CFTR CTTN NOXO1 DIAPH1 YWHAQ RHOG PKN2 PKN1 H2AZ2 NCKAP1L WASF1 WASF2 BAIAP2 CALM1 RHOC ABI2 NOXA1 YWHAE ABI1 NOX3 NOX1 PPP1R12A PPP1R12B CDC25C PPP1R14A IQGAP2 YWHAH KLK3 KTN1 KLK2 KDM4C DIAPH3 YWHAZ PPP1CB RAC2 S100A9 S100A8 ACTB CYFIP2 WIPF1 SCAI WIPF2 WIPF3 BTK ARPC1B ARPC1A CFL1 WASL PTK2 WAS PFN1 ROPN1 GOPC PFN2 TAX1BP3 FLNA NF2 PRC1 ROCK1 ROCK2 MYH9 ACTG1 NCKIPSD DVL1 DVL2 DVL3 ARPC4 ARPC5 KDM1A ARPC2 CTNNA1 ARPC3 NCK1 KIF14 ACTR3 RHOD ACTR2 EVL WASF3 MYL9 RHPN1 SFN MEN1 FMNL1 FMNL2 MYLK MYL12B CDKN1B MYH11 ABL1 MYL6 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 LIN7B KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 DLG4 PIK3R4 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PIK3C3 PPP2R5A PPP2R5D PPP2R5C DYNLL1 FMNL3 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PRKCB PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI LIMK2 TAOK1 SRGAP2 LIMK1 CENPK CENPL MYH14 CENPM MYH10 CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 MRTFA AR PRKCD PRKCA KIF5B KIF5A PIN1 H2AC19 H2AC14 H2BC12L IQGAP1 SRF H4C9 H2AC20 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism FADS1 SCP2 ACSL1 ELOVL1 ELOVL5 ACOT8 ELOVL2 HSD17B4 ACAA1 ELOVL3 ABCD1 FADS2 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation TIMP2 TIMP1 TGFBR3 MMP14 PSENEN MMP16 PSEN2 PSEN1 APH1A NCSTN APH1B TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism PPP1CC ABHD5 FABP12 PRKACA PPP1CB LIPE PRKACG PRKACB FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 CAV1 PLIN3 PNPLA4 PNPLA5 PLIN1 MGLL CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 CYBA NCF4 CD36 ITGAV ITGB5 CYBB RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling DNM2 DNAL4 AP2A1 AP2S1 AP2A2 SH3GL2 CLTC DNM1 CLTA DNM3 AP2M1 AP2B1 NTRK1 NGF NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors UBE2I TFAP2A TFAP2B WWOX TFAP2C TFAP2D TFAP2E SUMO1 KCTD1 KCTD15 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors H2AX H3-3B H3C8 FOS H2AJ SRC H3C15 NOS3 TGFA H2BC9 H2BC8 APOE H2BC5 PCK1 NRAS H2BC3 MAPK1 HRAS H2BC1 MAPK3 FOSB EGF BCL2 AREG H2AB1 H2AC8 H2AC6 H2AC7 RXRB RXRG ATF2 HDAC3 DLD PRKCZ XPO1 H2BC26 H2BC21 NRIP1 EP300 TBL1X PDPK1 H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 PIK3CA CREBBP H2BC11 NCOR1 TBL1XR1 CARM1 H2AZ2 TNRC6C TNRC6A CALM1 TNRC6B JUN CCNT1 FOXO3 MYLIP MYB TBP GTF2A1 GTF2A2 ANGPTL3 ABCG1 CETP CDK9 HDAC1 ABCA1 APOC4 GNGT1 NR1H3 GNGT2 APOC2 APOC1 FABP5 FABP6 CAV1 GNAT3 DHRS4 PLIN1 RARG PTK2 GNAI3 NCOR2 KAT2B IGF1R ZDHHC7 GNG10 CRABP2 RARB GNG3 ZDHHC21 GNAI1 PPID GNG2 GNAI2 CAV2 MMP7 GNG5 GNG4 UGT1A3 GNG7 PPP5C GNG8 GPS2 HSP90AB1 SPHK1 KDM4A CXCL12 FOXA1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD GNG12 NCOA3 GNG11 NR5A2 KDM3A GNG13 TFF3 KDM1B APOD TFF1 KANK1 GNB2 ARL4C CXXC5 EEPD1 GNB1 KDM4B PTGES3 GNB4 USF2 GNB3 USF1 ZNF217 GNB5 EBAG9 MMP2 GATA3 MMP9 FKBP5 ELK1 EREG CDKN1B UHMK1 BTC EPGN HBEGF CCND1 KPNA2 SMC3 PPARD EGFR GPAM SCD SP1 RAD21 STAG1 STAG2 ALDH1A1 SMC1A HSP90AA1 YY1 PDHB PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 CBFB PDHA1 RUNX1 CITED1 ADH4 ADH1C S1PR3 PRMT1 ADH1A FASN KCTD6 NR1H2 ESR1 POLR2A POLR2B POLR2C POLR2D POLR2E RXRA POLR2F ABCG8 POLR2G ABCG5 POLR2H POLR2I RARA ESR2 POLR2J PGR POLR2K POLR2L GTF2F1 KAT5 CRABP1 GTF2F2 AKR1C3 DHRS3 ALDH1A3 CYP26A1 SDR16C5 AXIN1 CYP26B1 CYP26C1 DHRS9 RDH11 H2AC19 ALDH1A2 H2AC14 RDH10 H2BC12L RDH16 AKT2 RDH5 MYC RDH14 AKT3 RDH13 ALDH8A1 AKT1 STRN MMP3 PIK3R3 PIK3R2 SRF PIK3R1 H4C9 JUND MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation FGFR1 FGF1 FGF2 CEP43 FGF4 FGF6 FGF9 FGF20 STAT5A FGF23 STAT5B GAB2 ZMYM2 PIK3R1 PIK3CA STAT1 LRRFIP1 STAT3 BCR CUX1 FGFR1OP2 MYO18A CPSF6 ERLIN2 TRIM24 BAG4 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RTEL1 RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL9A2 COL6A5 PPIB COL1A1 COL1A2 P4HB P4HA1 P4HA2 P4HA3 ADAMTS2 ADAMTS3 COL17A1 COL18A1 COLGALT2 PLOD3 COL15A1 COL16A1 PLOD2 PLOD1 COL13A1 COL14A1 COLGALT1 P3H2 COL11A1 P3H1 COL11A2 COL12A1 PCOLCE P3H3 COL19A1 COL10A1 PCOLCE2 SERPINH1 COL28A1 CRTAP COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 ADAMTS14 COL3A1 COL2A1 COL4A2 COL5A1 COL4A1 COL7A1 COL6A2 BMP1 COL5A3 TLL2 COL4A4 TLL1 COL5A2 COL6A1 COL4A3 COL4A6 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection AP1G1 RAC1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 PAK2 ATP6V1H NMT2 NPM1 XPO1 LCK FYN PPIA CD4 RCC1 DOCK2 NMT1 AP2A1 CCR5 CCNK RANBP1 AP2A2 CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB AP2M1 ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 HCK RBX1 TAF11 CD8B ELOA2 ELMO1 SSRP1 NEDD4L AP2S1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 AP2B1 LIG4 XRCC4 CXCR4 NUP205 POM121 NUP188 PSIP1 AAAS POM121C NUP42 NUP62 FURIN TPR BANF1 NUP88 RAE1 KPNA1 NUP214 NDC1 LIG1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 ARF1 NUP107 NUP160 KPNB1 NUP85 SEC13 NUP133 PDCD6IP RANGAP1 CHMP4C CHMP4B CHMP3 CHMP4A PSMD8 CHMP6 CHMP7 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 NUP43 PSMA5 PSMA6 PSMA3 CHMP2B PSMA4 CHMP2A PSMA1 PSMA2 RANBP2 UBA52 PSMD12 RAN PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NUP37 ADRM1 FEN1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CUL5 TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 CHMP5 XRCC6 XRCC5 CD28 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants ALK IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID CHUK IKBKB IKBKG NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation ADCYAP1R1 NTRK1 NTRK2 ADCYAP1 ADORA2A FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF9 FGF20 FGF23 FGF16 SOS1 FGF19 FGF18 FGFR4 NRAS FRS3 HRAS KLB FRS2 FGF1 FGF2 PTPN11 FGF4 FGF6 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism ACAT1 BDH1 OXCT1 OXCT2 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism ITPA RRM2 SAMHD1 DTYMK AK1 AK2 AK4 GLRX AK5 AK6 AK7 AK8 AK9 NUDT13 RRM1 NUDT16 NME3 CTPS2 ADPRM NUDT5 NME4 CTPS1 DCTD NME6 CMPK1 DCTPP1 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP ENTPD1 ENTPD5 ADA NT5C AGXT2 NT5C1A DPYS DPYD NT5M UPP2 UPP1 UPB1 TYMP NME2 GMPS NME1 IMPDH1 GUK1 IMPDH2 HPRT1 NUDT15 NT5E XDH CDA RRM2B GDA PFAS DNPH1 ATIC PPAT TK2 ADSL ENTPD2 ENTPD3 ENTPD4 ENTPD6 TK1 CAD ENTPD7 TYMS ENTPD8 UMPS GART NT5C2 PAICS DHODH UCKL1 TXN UCK2 UCK1 TXNRD1 PUDP NT5C1B ADSS1 ADSS2 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SZT2 SAMTOR SEH1L NPRL2 NPRL3 GCN1 WDR59 EIF2AK4 RPTOR FLCN MIOS ITFG2 IMPACT KPTN DEPDC5 WDR24 RRAGA SH3BP4 RRAGC FNIP1 RRAGB FNIP2 RRAGD KICS2 CASTOR1 CASTOR2 TCIRG1 SLC38A9 ATP6V1E1 RHEB ATP6V1E2 LAMTOR2 ATP6V0B LAMTOR1 ATP6V1G1 CEBPB LAMTOR4 ATP6V0E1 LAMTOR3 ATP6V1G2 RPL4 LAMTOR5 RPL5 RPL30 RPL3 RPL32 ATP6V1B2 RPL31 ATP6V0D1 RPL34 ATP6V0C RPL10L ATP6V0D2 RPL10A RPL8 RPL6 ATP6V1B1 RPL7 ATP6V1A RPS15 CEBPG RPS14 RPS17 RPS16 RPL18A ATP6V1H RPS19 RPS18 ATP6V0E2 RPL36AL ATP6V1G3 RPL36 ATP6V1D ATP6V1C1 ASNS RPL35 ATP6V1F RPL38 ATP6V1C2 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 ATF2 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 MLST8 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 SEC13 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 SESN2 RPL36A RPS27L RPS15A RPL14 MTOR RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A ATF4 TRIB3 ATF3 SESN1 DDIT3 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation TNFRSF10B CASP8 TNFRSF10A TNFSF10 FAS FASLG TRAF2 TICAM2 TICAM1 TLR4 LY96 CD14 RIPK1 FADD TRADD RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling NOTCH1 EP300 JAG1 RBPJ MAML2 CREBBP MAML1 RUNX3 KAT2B KAT2A MAMLD1 SNW1 HES1 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly PRKACA A2M ZDHHC8 PRKACG ABCA1 PRKACB APOA1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism ST3GAL1 CHST5 ST3GAL2 GALNS ST3GAL3 CHST2 OGN CHST3 OMD B4GALT2 B4GALT3 B4GALT1 HEXB HEXA SLC35D2 GNS GLB1L3 GLB1L2 B3GNT3 FMOD GLB1L ST3GAL6 GLB1 B4GAT1 B4GALT6 KERA B4GALT4 B4GALT5 CHST6 PRELP ACAN B3GNT7 B3GNT4 LUM CHST1 B3GNT2 ST3GAL4 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification NGRN MTERF3 FASTKD2 SLIRP RPUSD4 MTPAP RPUSD3 TRMT61B TRUB2 LRPPRC RCC1L BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds GSTT2 CYP1A2 GSTT1 OPLAH CNDP2 HPGDS TPST2 ESD CHAC2 CHAC1 TPST1 GSTT2B GSTM4 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT UGT1A10 GSTA5 ABHD10 GSTA4 UGT2B10 GSTM5 UGT2B11 UGT2B15 UGT2B17 SLC35D1 UGT3A2 UGT3A1 NAT1 NAT2 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGDH UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGT1A6 HEMK2 NNMT MTRR AHCY GSTO1 MTR MAT1A MAT2B COMT TRMT112 AS3MT MAT2A GLYATL3 GLYATL2 GSS GLYATL1 ACSM2A ACSM5 ACSM4 GLYAT UGP2 GGT7 PODXL2 GGT6 ABHD14B MGST3 SULT1A1 MGST1 SULT1C2 MGST2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 GGT3P SULT1A4 SULT4A1 SULT1A3 SULT1A2 SULT2A1 SULT1C4 GSTK1 ACSM1 ACSM2B UXS1 GSTM1 TPMT GSTA2 GSTA1 SLC35D2 UGT1A3 GGT1 GSTP1 GGT5 GSTA3 GCLC GCLM AKR1A1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR1 TGFBR2 TGFB1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation FGF9 WT1 GATA4 DMRT1 SOX9 ZFPM2 PTGDS SRY NR5A1 DHH AMH TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template UBE2L6 SPRTN TRIM25 VCP UBA52 POLK POLE POLH RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 ISG15 RPS27A RCHY1 UBA7 NPLOC4 PCNA POLD3 POLD4 POLD1 POLD2 UFD1 RPA1 RPA2 USP10 POLE4 REV3L PCLAF POLI RPA3 USP43 POLE2 REV1 POLE3 MAD2L2 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin HSP90AA1 EEF2 CD9 HSP90AB1 TXNRD1 HBEGF LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants FLT3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi MGAT1 MAN1A1 MANEA MAN1A2 MAN1C1 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway IL1RL2 IL36A IL36B IL36G IL1F10 IL36RN PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria PAH SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC ABHD3 PCTP CEPT1 MFSD2A PCYT1B CHKB PCYT1A CHKA STARD10 PHOSPHO1 PEMT CHPT1 ACHE SLC44A5 BCHE SLC44A3 SLC44A4 CSNK2A1 SLC44A1 CSNK2A2 SLC44A2 CSNK2B CHAT LPCAT1 LPIN1 STARD7 LPIN2 LPIN3 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation FGF22 FGFBP1 FGF1 FGFBP2 FGF2 FGF10 FGFBP3 FGF3 FGF7 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PSMA5 PRKAG1 PSMA6 PRKAG2 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PRKAG3 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 CD274 VCP SEL1L RNF185 PRKAB2 PRKAB1 PRKAA1 PRKAA2 RNF5 ERLEC1 PSMD8 PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion PPIA BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 PRKCB AP2A1 DVL2 AP2S1 FZD4 AP2A2 CLTC ARRB2 CLTA PRKCA AP2M1 AP2B1 CLTB WNT5A PRKCG REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PPARGC1B PSMD11 PSMD14 PSMD13 CUL1 PSMA7 CBFB TWIST1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 DLX5 PSMC6 DLX6 PSMC3 PSMC4 PSMC1 PSMC2 HIVEP3 STAT1 SKP2 NR3C1 ESR1 ESRRA SMURF1 GSK3B NKX3-2 MSX2 PPARGC1A WWP1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion HGS RAB5A VPS33B RAB7A UBB CORO1A UBA52 UBC RPS27A NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR KDR NRP2 NRP1 FLT1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation NOS3 NMT1 CALM1 NMT2 CYB5B HSP90AA1 LYPLA1 CYGB DDAH1 ZDHHC21 CAV1 SPR AKT1 TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling CHUK TNF UBA52 STUB1 UBE2D1 TNFRSF1A RBCK1 USP2 UBB IKBKE OPTN UBC RPS27A RACK1 UBE2D2 RNF31 MIB2 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 ULK1 TBK1 MAPKAPK2 ADAM17 SPPL2B SPPL2A SMPD3 SMPD2 CLIP3 TAX1BP1 NSMAF OTULIN TRADD UBE2L3 CASP8 TAB3 TAB2 TAB1 TRAF2 UBE2D3 IKBKB BIRC2 BIRC3 XIAP IKBKG RIPK1 FADD MAP3K7 BAG4 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing RCE1 GOLGA7 PDE6D CALM1 PRKCQ KRAS PRKG2 ARL2 ZDHHC9 ICMT NRAS LYPLA1 HRAS BCL2L1 ABHD17C USP17L2 FNTA ABHD17B FNTB ABHD17A DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) CBX6 PHC2 NFATC2 GATA3 PHC1 MTA2 CBX4 CBX2 ASH2L HDAC10 HDAC11 JUN PHC3 MAML2 MAML1 MEN1 MAF BMI1 RING1 FOS RNF2 NOTCH1 NOTCH2 MTA1 HDAC1 BATF MTA3 IL4R HDAC4 SATB1 SMARCA4 SNW1 IL4 IL13 KMT2A IRF4 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 DPY30 MBD3 WDR5 KLF13 STAT5A EP300 STAT5B GATAD2B TBL1X GATAD2A RBPJ POU2F2 HDAC5 HDAC2 CREBBP ETS1 POU2F1 HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 CHD4 RBBP4 CHD3 RBBP5 YY1 IL5 RBBP7 STAT6 CBX8 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation FGF23 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed SUMO2 SENP5 SENP2 SENP1 SUMO1 SUMO3 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport TTPA FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes FOXG1 CDKN1A FOXO4 CDKN1B FOXO1 FOXO3 PCBP4 CCNG2 RBL2 GADD45A SMAD2 MSTN CAV1 SMAD4 SMAD3 KLF4 BTG1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation RARS2 AARS2 MARS2 PARS2 DARS2 HARS2 YARS2 FARS2 KARS1 WARS2 GARS1 LARS2 SARS2 PPA2 NARS2 TARS2 QARS1 IARS2 VARS2 CARS2 EARS2 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency ATF4 TRIB3 ATF3 EIF2S3 EIF2S2 EIF2S1 GRB10 CEBPG PPP1R15A CHAC1 EIF2AK1 ASNS DDIT3 ATF5 CEBPB NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay TENT4B PAPOLG ZC3H18 RBM7 ZFC3H1 DXO DIS3 XRN2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC10 EXOSC2 EXOSC1 SRRT NCBP1 NCBP2 WDR82 MPHOSPH6 MTREX RBM27 TENT4A ZCCHC8 ZCCHC7 RBM26 YTHDC1 C1D ZC3H4 PABPN1 ZC3H3 YTHDC2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization FLT4 VEGFD KDR PGF VEGFB FLT1 VEGFC VEGFA PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL PPP2CA PPP2CB PTPN6 PPP2R1B PPP2R5E PPP2R1A APOB LRP8 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PLA2G4A FGR PECAM1 MAPK14 PTPN11 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2AC6 H2AC7 H2AX RBM7 TASOR PPHLN1 H3-3B H2AC19 H2AC14 H3C8 H2BC12L ATF7IP H2AJ SETDB1 H2BC26 H2BC21 MTREX H3C15 H2BC17 MORC2 H2BC12 H2BC13 H2BC14 H2BC15 EHMT2 H2BC9 EHMT1 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 MPHOSPH8 H4C9 ZCCHC8 H2AB1 H2AZ2 H2AC20 H2AC8 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins ITGA2B ITGB3 CRK FN1 PTK2 RAP1B FGB FGA RAP1A VWF FGG APBB1IP TLN1 SRC BCAR1 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination ATM H2AX SPO11 TEX15 MSH4 DMC1 MSH5 PSMC3IP MND1 MLH3 H3-3B H3C8 H2AJ H3C15 MLH1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 H2BC1 CDK4 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 MRE11 BRCA1 BRCA2 FIRRM PRDM9 NBN H2AC19 H2AC14 H2BC12L H2BC26 TOP3A H2BC21 RAD51C H2BC17 BLM H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 FIGNL1 RBBP8 H4C9 RPA1 RPA2 RAD50 H2AZ2 RAD51 RPA3 H2AC20 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CLOCK CSNK2A1 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin INHBB INHBA ACVR2A TGFBR3 INHA FSTL3 FST MAPK1 FOXH1 DRAP1 MAPK3 SMAD2 ACVR1C SMAD4 SMAD3 ACVR1B ACVR2B INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing EXOC1 INS MYO5A PCSK2 RAB27A PCSK1 MYRIP ERO1B KIF5C KIF5B KIF5A SLC30A8 SLC30A5 CLTRN EXOC8 CPE EXOC7 VAMP2 STX1A P4HB EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 HTR1D HTR6 HTR1A HTR7 HTR1B HTR5A DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System TGFA EGF AREG FGF10 PRL ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans ITGA2B COL9A2 LAMA2 LAMA1 LAMB2 LAMA4 LAMA3 LAMB1 LAMC1 VTN SERPINE1 SPARC NCAN HAPLN1 TNN BGN TNR DCN MUSK ASPN BCAN MATN1 VCAN MATN4 FMOD TNXB AGRN LRP4 DSPP ITGB5 ITGA9 NCAM1 TNC COMP IBSP ITGAX TGFB2 DMP1 ITGAV DAG1 HSPG2 PTPRS TGFB1 ITGB6 TGFB3 ITGA8 ITGB1 ITGB3 MATN3 ITGA2 ITGA7 ACAN COL9A1 LUM COL9A3 LAMA5 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC17A6 SLC25A18 SLC6A19 SLC25A22 SLC6A15 SLC6A13 SLC6A5 SLC6A14 SLC6A11 SLC22A2 SLC6A2 SLC22A1 SLC6A1 SLC6A4 SLC32A1 SLC6A3 SLC17A7 SLC6A20 SLC17A8 SLC6A7 SLC6A9 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation ADAM19 ADAM15 ADAM12 SH3PXD2A SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 FGF9 FGF20 FGF23 FGF16 SOS1 FGF19 FGF18 FGFR4 NRAS HRAS KLB FGF1 FGF2 FGF4 FGF6 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones DNAJB11 SULT1A3 EXTL2 PREB EXTL3 GOSR2 ADD1 FKBP14 MYDGF TATDN2 SERP1 SEC31A GFPT1 TSPYL2 DDX11 WIPI1 PDIA6 PDIA5 ATP6V0D1 ERN1 CTDSP2 KDELR3 SHC1 HSPA5 DCTN1 CXXC1 EXTL1 SSR1 DNAJB9 ZBTB17 KLHDC3 WFS1 EDEM1 YIF1A SRPRA ACADVL SRPRB TPP1 HDGF GSK3A PLA2G4B LMNA HYOU1 CUL7 PPP2R5B SYVN1 ARFGAP1 DNAJC3 TLN1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI PCNA UBA52 RFC5 RFC3 RPA1 RPA2 RFC4 UBB RFC1 REV3L RFC2 UBC RPA3 POLI RPS27A REV1 MAD2L2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening H2AC6 H2AC7 H2AX H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 UBTF H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 MAPK3 H4C9 MBD2 H2AB1 H2AZ2 H2AC20 H2AC8 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers CBX6 PHC2 EZH2 PHC1 CBX4 CBX2 PHC3 RAC1 MDM2 BMI1 RING1 VAV1 SRC PIP5K1A RNF2 PIP5K1B TGFA MET RICTOR SUZ12 NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 PLCG1 CD86 EGF FRS2 CD80 AREG CD19 PRKCE THEM4 NRG2 NRG3 NRG4 ATF2 HDAC3 HGF PRR5 GSK3B PIK3CD PIK3CB PIK3CG PIP5K1C MLST8 EED PDPK1 EGR1 IRAK1 PIK3CA LCK CHD4 RBBP4 CHD3 FYN TRAF6 RBBP7 RHOG PTPN11 MTOR TNRC6C INS TNRC6A CALM1 SALL4 MTA2 TNRC6B REST JUN PRKACG PRKACB FOXO3 PIP4K2A PIP4K2B PDGFRA PDGFB KIT IL33 RAC2 HDAC1 IL1RL1 SNAI2 ADCY9 PRKAR1B PRKAR2B TP53 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 PRKAR2A ADCY6 ADCY5 CAMK4 KDM1A SNAI1 PREX2 TRIM27 USP13 TNKS TNKS2 WWP2 RNF146 FRK OTUD3 RCOR1 RPTOR TSC2 RRAGA RRAGC USP7 RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CDKN1A EREG CDKN1B BTC EPGN HBEGF FLT3 PRKCG KPNA2 PPP2R1B PPP2R1A NBEA EGFR KLB IRS1 IRS2 MBD3 FGF1 BAD FGF2 CASP9 FGF3 NRG1 FGF4 FGF6 FGF7 CAMKK1 FGF9 CAMKK2 FGF20 GATAD2B FGF23 PPP2R5E GATAD2A FGF22 GAB2 FGF16 FGF19 FGF18 PPP2R5B HDAC5 FGFR4 PPP2R5A FGF10 PPP2R5D HDAC2 PPP2R5C HDAC7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 PML PPP2CA CHUK PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYD88 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PDGFRB ADRM1 TRAT1 SEM1 IRAK4 NTRK3 PIK3AP1 PSMC5 IER3 SGK1 PSMC6 PHLPP2 PSMC3 PHLPP1 PSMC4 FLT3LG PSMC1 ATN1 FOXO6 PSMC2 MAF1 FOXO4 FOXO1 RPS6KB2 MTA1 MTA3 ESR1 NEDD4 AHCYL1 GSK3A ESR2 PPARG NR4A1 PRKACA PDE1C PDE1B PDE1A GRK2 NR2E1 PRKCD PRKCA CAMK2B CAMK2D CAMK2A ITPR1 MECOM ITPR2 PTEN AKT2 ITPR3 AKT3 PRKAR1A AKT1 ERBB2 STRN CAMK2G CSNK2A1 CSNK2A2 CSNK2B TRIB3 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR MOV10 AGO3 AGO4 AGO1 MKRN1 AGO2 CD28 CBX8 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism PHKB CALM1 UBA52 PHKA1 PHKA2 PPP1R3C NHLRC1 AGL UBB UBC PGM1 RPS27A GYG2 GYG1 EPM2A PYGB AKR1E2 GBE1 PYGM PYGL GYS2 GYS1 UGP2 GAA PHKG1 PHKG2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants PDGFRA REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2CA PPP2CB ATM PPP2R1B PPP2R1A PHF20 UBA52 CHEK2 TP53 MDM2 MDM4 USP7 CCNG1 USP2 CDK1 PRDM1 PRR5 AKT2 UBB AKT3 CCNA2 UBC AKT1 CCNA1 RPS27A MLST8 PDPK1 SGK1 MAPKAP1 RICTOR CDKN2A PPP2R5C RNF34 DAXX RFFL CDK2 MTOR DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells EGF FGF2 FGF10 FGF4 FGF7 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis ENO3 ALDOB ENO4 ALDOA G6PC2 G6PC3 G6PC1 GAPDHS PC PGK1 SLC37A4 PCK2 GAPDH FBP1 FBP2 PCK1 TPI1 PGAM1 PGAM2 GPI PGK2 ENO1 ENO2 SLC37A1 ALDOC MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades FN1 RAC1 IL6 JAK1 CDK1 SRC PAK1 TGFA MET PAK3 PAK2 SHC2 SHC3 ICMT SHC1 YWHAB NRAS RAP1A FRS3 MAPK1 GRIN2B HRAS RALGDS MAPK3 MAP2K1 MAP2K2 EGF FRS2 BRAF AREG BCL2L1 MAPK12 PRKCQ RAG2 SOS1 RAG1 NRG2 NRG3 RASGRP4 NRG4 HGF GFRA1 PIK3CB XPO1 GDNF PDE6D PIK3CA IL2 IL3 CDC42 FYN CSK RASGRP1 PTPN11 RASGRP3 TNRC6C CDC14A TNRC6A CALM1 TNRC6B JUN KRAS PRKACG PRKACB FOXO3 KALRN PDGFRA PDGFB RBX1 KIT PPP1CB MARK3 RET GOLGA7 CDC42EP5 CDC42EP3 CDC42EP2 PTK2 ZDHHC9 ARL2 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 PPP5C NEFL NCOA3 FNTA CSF2 FNTB ITGA2B SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 IL2RG JAK3 RASAL3 DAB2IP NF1 KBTBD7 TYK2 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 LAMTOR2 LAMTOR3 EREG SPTAN1 CCND3 BTC SPTB EPGN HBEGF NCAM1 RANBP9 FLT3 DUSP16 PPP1CC PPP2R1B PPP2R1A EGFR RASGRF2 LYPLA1 RASGRF1 HSPB1 KLB DLG1 IRS1 DLG3 DLG4 IRS2 FGF1 FGF2 FGF3 NRG1 ABHD17C USP17L2 FGF4 FGF6 ABHD17B FGF7 ABHD17A RCE1 FGF9 FGF20 FGF23 PPP2R5E FGF22 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A FGF10 PPP2R5D PPP2R5C PSMD8 PSMD6 IL6R PSMD7 PSMD2 DUSP10 PSMD3 DUSP5 PSMD1 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PPP2CA PTPN3 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DUSP4 PDGFRB ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 FLT3LG PSMC1 PSMC2 FOXO1 WDR83 PTPRA RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 SHOC2 SEPTIN7 CDC14B ARTN RASGEF1A ETV4 GFRA3 IGF2BP1 MAPK6 GFRA2 MAPK4 ANGPT1 GFRA4 TEK NRTN PTPN7 PRKACA PSPN PRKG2 CAMK2B CAMK2D CAMK2A MYC ERBB2 CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 PIK3R2 IQGAP1 PIK3R1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 IL5RA CNKSR1 CSF2RB MAPKAPK5 RAF1 CSF2RA TLN1 IL5 MOV10 VCL IL2RB AGO3 MAP3K11 IL3RA AGO4 AGO1 AGO2 DNAJB1 IL2RA COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway ITGA2B ANO5 APP F5 F8 SERPINE1 GPC1 F12 KLKB1 GPC3 GPC2 PRTN3 GPC5 F7 GPC4 F9 GPC6 PROZ AGRN GP1BA F3 PROS1 SERPINC1 F10 F2 PROC SERPINE2 SERPINA5 THBD SERPING1 SMPD1 PF4V1 CD177 PROCR F11 F13B F13A1 GP9 GP1BB HSPG2 GP5 F2R SDC4 SDC2 SDC3 KNG1 SERPINA10 SDC1 ITGB3 ADAMTS13 FGB FGA SERPIND1 VWF FGG PF4 ANO6 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs PRKAA2 PRKAB1 CAMKK2 PRKAG1 CALM1 PRKAG2 PRKAG3 PRKAB2 PRKAA1 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A PPP2R5B PPP2R5A PPP2R5D PPP2R5C LCK CTLA4 LYN YES1 CD86 AKT2 FYN CD80 AKT3 AKT1 PTPN11 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures ATM MUS81 MRE11 BRCA1 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM NBN GEN1 RMI2 SLX1B RMI1 TOP3A SPIDR SEM1 RAD51B RAD51D RAD51C DNA2 BLM RTEL1 RAD51AP1 WRN BRIP1 SLX4 FIGNL1 RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus BANF1 LIG4 KPNA1 XRCC4 XRCC6 XRCC5 HMGA1 PPIA PSIP1 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS SFTPB FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation FGF9 FGF20 FGF23 TGFBR3 GIPC1 ANOS1 FGF1 FGF2 FGF4 FGF6 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels ABCC9 KCNJ1 GNG10 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ11 KCNJ8 ABCC8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression EPAS1 NR3C1 PTK6 PELP1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition RPS2 EIF2S3 EIF2S2 EIF2S1 FAU EIF4E EIF4B RPS27A EIF4G1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 EIF5 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 PPP2CA PPP2CB PPP2R1A SOS1 UBA52 UBB FGF1 FGF2 UBC FGF4 RPS27A CBL FGF9 FGF20 FGF23 FGF16 MKNK1 FGF18 SPRY2 PIK3R1 PIK3CA NRAS GAB1 MAPK1 FRS3 HRAS GALNT3 MAPK3 PLCG1 FRS2 BRAF PTPN11 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX3 ACOT8 HSD17B4 ACOXL ACOX2 AMACR CRAT CROT DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding OGG1 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism B3GALT6 ST3GAL3 OGN CHST3 PAPSS2 OMD GPC1 B4GALT1 HSPG2 GPC3 GPC2 SDC4 HEXB NCAN SDC2 GPC5 HEXA SDC3 GPC4 BGN GPC6 DCN BCAN VCAN FMOD AGRN CHST14 CSPG5 EXT1 EXT2 CSPG4 SDC1 KERA B4GALT7 SLC26A2 CHST6 PRELP ACAN CHSY1 B3GAT3 LUM RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade FN1 JAK1 SRC TGFA MET SHC2 SHC3 ICMT SHC1 YWHAB NRAS RAP1A FRS3 MAPK1 GRIN2B HRAS RALGDS MAPK3 MAP2K1 MAP2K2 EGF FRS2 BRAF AREG BCL2L1 MAPK12 PRKCQ SOS1 NRG2 NRG3 RASGRP4 NRG4 HGF GFRA1 PIK3CB GDNF PDE6D PIK3CA IL2 IL3 FYN CSK RASGRP1 RASGRP3 CALM1 KRAS PDGFRA PDGFB RBX1 KIT PPP1CB MARK3 RET GOLGA7 PTK2 ZDHHC9 ARL2 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 PPP5C NEFL FNTA CSF2 FNTB ITGA2B SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 IL2RG JAK3 RASAL3 DAB2IP NF1 KBTBD7 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 LAMTOR2 LAMTOR3 EREG SPTAN1 BTC SPTB EPGN HBEGF NCAM1 RANBP9 FLT3 DUSP16 PPP1CC PPP2R1B PPP2R1A EGFR RASGRF2 LYPLA1 RASGRF1 KLB DLG1 IRS1 DLG3 DLG4 IRS2 FGF1 FGF2 FGF3 NRG1 ABHD17C USP17L2 FGF4 FGF6 ABHD17B FGF7 ABHD17A RCE1 FGF9 FGF20 FGF23 PPP2R5E FGF22 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A FGF10 PPP2R5D PPP2R5C PSMD8 PSMD6 PSMD7 PSMD2 DUSP10 PSMD3 DUSP5 PSMD1 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PPP2CA PTPN3 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DUSP4 PDGFRB ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 FLT3LG PSMC1 PSMC2 WDR83 PTPRA RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 SHOC2 ARTN RASGEF1A GFRA3 GFRA2 ANGPT1 GFRA4 TEK NRTN PTPN7 PSPN PRKG2 CAMK2B CAMK2D CAMK2A ERBB2 CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 PIK3R2 IQGAP1 PIK3R1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 IL5RA CNKSR1 CSF2RB RAF1 CSF2RA TLN1 IL5 VCL IL2RB MAP3K11 IL3RA IL2RA RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN MRM1 HSD17B10 MRM2 MRM3 ELAC2 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 CDH1 CTNNB1 MAPK8 BMX PAK2 CDKN2A YWHAB STAT3 MAPK1 MAPK3 TP73 BCL2 BCL2L1 PRKCQ LY96 YWHAG IRF1 TLR4 YWHAQ PPP3R1 NMT1 YWHAE FASLG C1QBP LMNB1 UNC5A BCL2L11 DAPK1 MAGED1 UNC5B DAPK2 DAPK3 YWHAH APPL1 YWHAZ PTK2 TP53 AVEN DIABLO CARD8 UACA ROCK1 DCC CDC37 VIM BCAP31 FNTA KPNA1 SFN CASP7 DBNL GAS2 MAPT ADD1 PLEC BBC3 SPTAN1 E2F1 APC TFDP1 TFDP2 GSN KPNB1 BID MLKL BAD CASP9 TRADD HMGB1 UBE2L3 CASP8 CASP5 DFFB CASP4 DFFA FLOT1 TNFSF10 HMGB2 CASP1 FLOT2 TP63 PDCD6IP RIPK3 IL18 TRAF2 DYNLL1 IL1A IL1B IRF2 PELI1 HSP90AA1 DYNLL2 CHMP4C CHMP4B CHMP3 CHMP4A APIP PSMD8 CHMP6 CHMP7 PSMD6 BIRC2 PSMD7 BIRC3 PSMD2 PRKN PSMD3 XIAP PSMD1 SDCBP RIPK1 FADD BAK1 ELANE GSDMD TNFRSF10B GZMB PSMA5 TNFRSF10A PSMA6 ITCH PSMA3 CHMP2B PSMA4 CHMP2A PSMA1 FAS PSMA2 CYCS UBA52 BAX STUB1 PSMD12 OGT GSDME PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 TICAM2 TP53BP2 PSMB7 TICAM1 PSMB4 PSMB5 CD14 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DSP TJP1 OCLN CASP3 DSG1 SATB1 PKP1 DSG2 DSG3 TJP2 PMAIP1 CLSPN PRKCD OMA1 STK24 CASP6 STK26 OPA1 DNM1L ACIN1 PPP1R13B AKT2 AKT3 AKT1 APAF1 ARHGAP10 PPP3CC BMF PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling UBE2L6 CHUK PPP2CA HERC5 PPP2CB ADAR EIF2S3 EIF2S2 EIF2S1 HSPA1A SNCA CDK1 CENPX CENPS STAT1 HSPA1B UBE2I STAT3 SUMO1 HSPA8 PPP2R1B FANCC PPP2R1A TRIM25 PTPN2 DUS2 MAVS TP53 NPM1 FAAP100 EIF2AK2 ISG15 SPHK1 PRKRA TARBP2 PPP2R5A NCK1 FAAP24 FAAP20 HSPA1L ILF3 ILF2 DNAJC3 IKBKB ARIH1 DHX9 FANCM FANCL FANCA HSPA2 FANCB IKBKG FANCE FANCG MAP2K6 FANCF TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling DOK2 SOS1 PIK3R2 PIK3R1 PIK3CA SHC1 GRB7 NRAS ANGPT4 HRAS ANGPT2 GRB14 ANGPT1 TEK PIK3CB PTPN11 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina CASP6 LMNB1 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate AMY2B AMY1A TREH AMY1B AMY1C CHIT1 SI CHIA MGAM LCT AMY2A C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) UBE2M UBE2D1 PAK1 PAK3 PAK2 UBE2D2 NRAS HRAS CDC34 UBE2V1 NFKB2 MUC12 MUC13 MUC15 MAP3K14 MUCL1 MUC3A ICAM2 MUC5AC ICAM3 MUC3B RELB RPS6KA5 CD209 UBE2N CASP8 EP300 TAB3 TAB2 PDPK1 TAB1 MUC1 CREBBP MUC2 IL1B MUC7 MUC4 MUC6 MUC16 PSMD8 MUC17 IKBKB PSMD6 MUC19 FYN PSMD7 TRAF6 PSMD2 MUC5B PSMD3 MUC20 PPP3CA PSMD1 MUC21 PPP3CB IKBKG BTRC MAP3K7 SKP1 PPP3R1 NFATC3 CHUK NFATC2 FBXW11 NFATC1 PSMA5 CALM1 FCER1G PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRKACG UBA52 CARD11 PSMD12 PRKACB PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 AHCYL1 PLCG2 PRKACA SYK PRKCD ITPR1 CLEC10A CLEC4A ITPR2 CLEC4C PYCARD CLEC4D ITPR3 CLEC4E CLEC7A CLEC6A CARD9 LYN RAF1 UBA3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 EIF5 RPS13 EIF5B RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi NOTCH1 NOTCH2 FURIN TMED2 ST3GAL3 LFNG NOTCH3 SEL1L NOTCH4 RFNG B4GALT1 MFNG RAB6A ST3GAL6 ATP2A3 ATP2A2 ATP2A1 ST3GAL4 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB HADHA ACADM ECHS1 MECR HADH GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors GGCX GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants HSP90AA1 CDC37 ERBIN ERBB2 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome MEFV HMOX1 CASP1 APP NLRP3 PSTPIP1 NFKB2 RELA P2RX7 PYCARD TXNIP TXN HSP90AB1 SUGT1 PANX1 NFKB1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PLXNA2 PLXNA3 FES SEMA3A RAC1 RND1 FARP2 RRAS PLXNA1 NRP1 FYN TLN1 PLXNA4 PIP5K1C DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) SLC6A19 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT4 CNOT6 CNOT7 TNKS1BP1 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B PABPC1 BTG4 ZFP36L2 PABPN1L EIF4G1 DICER1 EIF4A2 EIF4A1 PAIP1 CNOT10 EIF4A3 CNOT11 CNOT6L AGO2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB CAMK2B CAMKK1 CAMK2D CAMKK2 CAMK2A CALM1 CAMK4 CAMK2G KPNA2 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A LDB1 PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A COL4A5 RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 ELOB RPL26L1 PSMD14 PSMD13 ELOC SLIT2 PSMA7 ROBO1 NCBP1 PSMB6 NCBP2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4A3 CASC3 MAGOH RBM8A DAG1 HOXA2 ISL1 GSPT2 GSPT1 UPF3B UPF3A MAGOHB ROBO2 RNPS1 UPF2 PABPC1 ZSWIM8 MSI1 CUL2 LHX3 LHX2 LHX4 LHX9 USP33 ETF1 SLIT1 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling IL1RL1 IL33 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins TACR2 TACR3 TACR1 TAC3 TAC1 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism GPT RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription KCTD6 CBFB RUNX1 ESR1 GPAM AXIN1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation CTNNB1 GATA4 PAX6 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 FFAR4 ISL1 LEP FFAR1 GCG GNG13 GRP GPR119 GNB1 TCF7L2 GNAT3 DPP4 GNB3 GIP CDX2 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 EEF1A1 RPL39 RPS10 RPS13 EEF2 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription RB1 ZCRB1 VHL DDX5 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate SLC35D1 UGP2 SLC35D2 UXS1 UGDH MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands CRH DLL1 HDAC1 SIN3A SST BDNF CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants PPP1CC SHOC2 ARAF PPP1CB RAF1 BRAF YWHAB MRAS THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) F2RL2 F2RL3 GNA13 GNA12 GNAQ GNG10 F2R GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ARRB1 ARRB2 GNA14 GNGT1 GNA15 GNA11 MAPK1 GNGT2 GNG12 MAPK3 GNG11 GNG13 F2 GNB2 GNB1 GNB4 GNB3 GNB5 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 MAGT1 JAK1 HLA-A ANO10 B2M TUFM IFNB1 VHL YWHAB STAT1 TUSC3 CTSL TBK1 TMEM258 IRF3 VCP UBE2V1 GEMIN2 OST4 SNRPD2 SNRPD1 SNRPD3 OSTC STT3A CSNK1A1 SNRPG STT3B GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 GSK3B CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 UBE2N YWHAG TAB3 TAB2 PDPK1 TAB1 IRAK1 DDOST CREBBP DAD1 TRAF6 YWHAQ PTPN11 PTPN6 YWHAE BECN1 UVRAG MAP1LC3B ISCU YWHAH YWHAZ GJA1 ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 ZDHHC8 CAV1 ZDHHC2 ZDHHC3 IFNA5 IFNA4 FUT8 IFNA7 GANAB IFNA6 MAN2A1 IFNA1 MGAT5 ST3GAL4 IFNA2 IFNA8 MGAT1 IFIH1 MGAT2 GOLGA7 RNF135 TRIM25 ST3GAL1 ST3GAL2 IFNA21 ST3GAL3 IFNA14 ST6GAL1 IFNA16 LARP1 EDEM2 IFNA17 MOGS SIKE1 ZDHHC11 MAVS IFNA10 MGAT4C ZDHHC9 RIGI SRPK2 MGAT4A SRPK1 MGAT4B HSPG2 MAN1B1 ST6GALNAC3 ST6GALNAC4 SDC4 SDC2 SDC3 VPS33A VPS33B ZCRB1 NRP1 G3BP1 G3BP2 HSP90AB1 SDC1 CNBP NLRP3 DDX5 SFTPD NLRP12 NUP205 POM121 IL17F IL17A NUP188 AAAS POM121C NUP42 IFNAR1 NUP62 FURIN TPR NUP88 RAE1 NUP214 SFN NDC1 NUP210 NUP155 GPC1 NUP153 NUP93 TYK2 GPC3 NUP50 NUP35 GPC2 NUP54 GPC5 GPC4 VPS39 STAT2 VPS18 GPC6 ATG14 VPS11 VPS16 AGRN TMPRSS2 ACE2 RB1 HAVCR1 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC SEC23A NUP107 RPS11 SAR1B KPNA2 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 SEC24B SEC24A RPS5 RPS6 RPSA VPS41 VPS45 NUP160 SEC24D SEC24C RPS4Y2 HLA-H RPS4Y1 HLA-C HLA-F NUP85 PIK3R4 HLA-G HLA-E ISG15 RPS26 TOMM70 RPS25 IL17RC RPS28 RPS27 IL17RA RPS29 TLR1 RPS20 TLR2 RPS21 SEC13 RPS24 RPS23 NUP133 PIK3C3 RPS4X HSP90AA1 CHMP4C CHMP4B RPS3A CHMP3 CHMP4A CHMP6 IKBKB CANX CHMP7 RPS27L IKBKG RPS15A MAP3K7 RPS3 CHUK RPS2 NUP43 CHMP2B CHMP2A RANBP2 UBA52 FAU HLA-B RIPK2 TRAF3 UBB IKBKE UBC RPS27A NUP37 PRMT1 TRIM4 NOD1 NOD2 TJP1 IRAK2 UBE2I SUMO1 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 AKT2 TLR8 TLR7 AKT3 AKT1 MASP1 MBL2 RPN2 RPN1 IRF7 ANO8 ANO9 STING1 ANO6 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription HEYL SP1 ILF3 SNAI1 PRDM8 ZEB2 BHLHE22 HOXC8 FOXF1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling UBA52 STUB1 NRG2 NRG3 EGFR NRG4 ERBIN AKT2 UBB AKT3 ERBB2 UBC AKT1 RNF41 NRG1 RPS27A CUL5 USP8 MATK EREG BTC HBEGF HSP90AA1 CDC37 PTPN18 EGF PTPN12 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases GYG2 GYG1 EPM2A G6PC3 GBE1 G6PC1 UBA52 GYS2 GYS1 PPP1R3C NHLRC1 GAA UBB SLC37A4 UBC RPS27A MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling SLC25A27 UCP3 SLC25A4 UCP2 SLC25A14 UCP1 PM20D1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling RAC1 RYK CTNNB1 CLTB PRKCG TCF7 RHOA PARD6A DAAM1 SCRIB CLTC RAC3 CLTA LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PPP3CA TCF7L2 PSMD1 PPP3CB TCF7L1 MAP3K7 PPP3R1 TNRC6C PRKCB NFATC1 PSMA5 TNRC6A CALM1 AP2A1 PSMA6 TNRC6B PSMA3 AP2A2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PRICKLE1 AP2M1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 AP2S1 PSMC4 PSMC1 PSMC2 RAC2 GNGT1 AP2B1 GNGT2 WNT5A SMURF2 SMURF1 GNAT2 PRKG2 PRKG1 PRKCA PLCB3 PFN1 PLCB1 PLCB2 NLK PDE6B GNG10 CAMK2A PDE6A GNG3 PDE6G ITPR1 GNAO1 GNG2 ITPR2 WNT11 GNG5 ITPR3 GNG4 GNG7 GNG8 WNT1 WNT4 FZD1 FZD3 DVL1 FZD2 DVL2 FZD5 WNT5B DVL3 FZD4 ROR1 ROR2 FZD7 ARRB2 FZD6 FZD8 GNG12 GNG11 GNG13 GNB2 MOV10 GNB1 AGO3 AGO4 GNB4 GNB3 VANGL2 AGO1 GNB5 AGO2 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome GLI3 PSMA5 PSMA6 PSMA3 PRKACA PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PSMD11 PRKACB PSMD14 PSMD13 CUL1 PSMA7 CSNK1A1 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SUFU PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling FGF9 FGF20 FGF23 FGF22 FGF16 SOS1 FGF18 FGF10 NRAS FRS3 HRAS FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FGF7 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin TTLL13 TTLL11 TTLL12 TTLL9 TTLL8 TUBA1C TUBA1B TUBA1A TUBB8 TUBB8B TUBB2B TUBB2A TTLL10 TPGS1 TUBA3E TTL TPGS2 SVBP TUBA3D AGTPBP1 TUBA3C LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 TUBB6 AGBL4 TUBB3 TTLL6 TUBB1 TUBB4B TTLL5 TUBB4A TTLL4 AGBL1 TTLL3 TTLL2 AGBL3 TTLL1 AGBL2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane MTMR10 MTMR12 PIK3C3 FIG4 PIKFYVE PIK3C2A INPP4A PI4K2B INPP4B MTMR2 PI4K2A VAC14 MTMR4 PIK3R4 MTM1 INPP5F DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 B4GAT1 LARGE1 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 SGCE LAMA3 SNTG2 SGCD LAMC2 SGCA SGCB LAMB1 LAMC1 DMD DAG1 SGCG SNTA1 DTNA DTNB HSPG2 SGCZ SSPN SNTB1 SNTB2 AGRN UTRN DRP2 LAMA5 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic H2AX GORASP1 H3-3B RAB1A H3C8 RAB1B USO1 H2AJ CCNA2 CCNA1 H3C15 CDKN2D CDKN2B CDKN2C CDKN2A KIF20A H2BC9 H3-4 H2BC8 H2BC5 FBXL18 H2BC3 H2BC1 SET KIF23 H2AB1 NEK2 H2AC8 H2AC6 CDC6 H2AC7 GSK3B H2BC26 H2BC21 YWHAG H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RBBP4 H2AZ2 CDC14A GTSE1 FKBPL PRIM2 PRIM1 POLA1 HJURP POLA2 MIS18BP1 ESCO1 ESCO2 PTK6 LIN54 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B TUBB6 TICRR TUBB3 TUBB1 PRKAR2B TUBA4B TUBA4A TP53 TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 NUP214 NDC1 LIG1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 NEK9 NEK6 NEK7 HMMR KPNB1 PHLDA1 HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 KMT5A BTRC SKP1 PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 RAN PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 OPTN PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 CPAP PSMC5 MAX PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TOP2A UBE2I FOXM1 SUMO1 AKAP9 PRKCA FIRRM CCP110 CEP250 POLE CDK5RAP2 RFC5 CEP135 RFC3 EML4 CEP131 RFC4 CSNK1D RFC1 RFC2 DNA2 PCNA CEP70 POLD3 POLD4 CEP72 VPS4A CEP192 POLD1 E2F4 POLD2 CEP76 E2F5 CEP78 PLK4 E2F6 RPA1 ODF2 RPA2 POLE4 RPA3 POLE2 POLE3 ANAPC15 CEP57 ANAPC16 ANAPC7 CETN2 UBE2C PLK1 CEP164 UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A PCM1 CCNB1 CDC23 UBE2S CDC26 CNTRL CDC27 ARPP19 CDC16 NCAPH2 CDK1 NCAPG2 ANAPC4 NIPBL ANAPC5 ENSA ANAPC1 TNPO1 NCAPD3 ANAPC2 RAB2A CEP290 NINL CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL RAB8A GORASP2 OFD1 MCPH1 PPP2R2D TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 MAPK1 HAUS1 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E NEDD1 ALMS1 CEP41 CEP43 XPO1 EP300 ANKLE2 PTTG1 EMD MYBL2 LEMD3 RCC1 AURKA RRM2 YWHAE PPP1R12A CDC25C CDC25A CDC25B LMNB1 GOLGA2 SMC4 SPAST SMC2 CC2D1B SIRT2 TUBGCP2 NCAPG TUBB8 NCAPH IST1 VRK1 TUBGCP5 LEMD2 TUBGCP6 TUBB8B TUBGCP3 TUBGCP4 ESPL1 RBX1 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 PPP1CB NCAPD2 HDAC1 CDC7 LPIN1 LPIN2 LPIN3 PPP2R2A HSP90AB1 FBXO5 DYRK1A DHFR TK1 TYMS PPP2R3B GINS1 GINS2 CDC45 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 ABL1 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT LBR STAG1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 BIRC5 CHMP4A KIF2C CHMP6 KIF2B CHMP7 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CHMP2B CLASP1 DYNC1I1 CHMP2A CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ GMNN TPX2 SPC24 MAD2L1 CENPS NUP37 CDT1 SPC25 FEN1 MCM10 DBF4 FBXL7 RPA4 PKMYT1 CCNH PRKACA CDK7 MNAT1 RBL2 H2AC19 RBL1 H2AC14 H2BC12L AKT2 MYC AKT3 AKT1 CSNK2A1 CSNK2A2 CSNK2B JAK2 LYN H4C9 AJUBA H2AC20 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope PKP4 FURIN PCSK6 CAPNS1 CAPN1 TCHH TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ LIPN LIPM PRSS8 LIPK TGM5 DSP RPTN CELA2A SPINK6 SPINK5 DSG1 KAZN PKP1 LCE1E DSG2 LCE1F DSG3 LCE1C LCE1D LCE2B LCE2C LCE2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 FLG SPRR2E SPRR2F SPRR3 SPRR2G PERP CSTA KLK5 EVPL PPL KLK8 LCE2D LCE3C LCE3D LCE3A LCE3B LELP1 PI3 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B JUP KLK13 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function EZH2 FURIN H2AX PCSK6 ANK3 MDM2 H3-3B H3C8 MTBP CSNK2A3 H2AJ SRC CTNND1 CDH1 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RB1 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 MAPK3 FOXQ1 H2AB1 TLE1 ZBTB33 POMT2 CTSL H2AC8 H2AC6 PKM H2AC7 DNM2 MYCN TMEM258 POMT1 SEC11A KLF9 MCRIP1 SEC11C FOXJ2 STRAP FOXP2 OST4 SP1 OSTC STT3A ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 SPCS3 H2BC13 SPCS2 H2BC14 SPCS1 H2BC15 DAD1 HDAC2 H2BC11 JUP SIRT1 TCF3 PSMD8 RBBP4 CANX PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 PSMD1 H2AZ2 KMT5A TGIF2 KLF4 TNRC6C PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 PSMA7 TWIST2 TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC ARHGAP32 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 KDM1A CTNNA1 H4C9 SNAI1 VCL MOV10 AGO3 AGO4 H2AC20 AGO1 ZNF217 AGO2 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation EZH2 H2AX PAX6 ASH2L JUN H3-3B H3C8 H2AJ KMT2D H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 KDM6A H2BC1 POLR2A POLR2B POLR2C H2AB1 POLR2D POLR2E RXRA POLR2F RARG POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 RARA POLR2J POLR2K POLR2L CNOT6 KMT2C EGR2 HOXA2 HDAC3 CNOT9 RARB H2AC19 H2AC14 H2BC12L PAXIP1 DPY30 H2BC26 H2BC21 WDR5 EP300 EED H2BC17 HOXB4 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP CTCF NCOA6 PCGF2 PAGR1 H2BC11 HOXA3 HOXA1 PKNOX1 HOXA4 NCOR1 NCOA3 PIAS2 HOXB3 H4C9 HOXB2 RBBP4 HOXB1 RBBP5 YY1 AJUBA HOXD1 HOXC4 RBBP7 PBX1 MEIS1 H2AZ2 MAFB H2AC20 HOXD4 HOXD3 ZNF335 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization ACBD5 UBE2D1 SLC25A4 SLC25A6 SERP1 PMPCB PMPCA VDAC1 VAMP2 STX1A UBE2D2 GNPAT OTC TOMM70 USP9X TOMM20 TOMM22 HMOX1 CHCHD4 CHCHD5 CHCHD2 CHCHD7 CMC4 CMC2 SLC25A17 PAM16 COX19 COX17 PEX11B TIMM50 BAG6 PITRM1 LDHD GRPEL2 DNAJC19 HSCB BCS1L COA4 FIS1 UBE2D3 CHCHD10 TIMM44 CS EMD TIMM10B PXMP2 PXMP4 ACO2 TIMM17A CYC1 TIMM17B GET1 GET3 FXN COA6 CAT GET4 CAMLG TIMM23 TIMM22 TIMM21 NDUFB8 TOMM40 APP SLC25A12 TAFAZZIN TIMM9 UBA52 TIMM13 SLC25A13 TIMM10 HMGCL ATAD1 PEX16 UBL4A TIMM8B TIMM8A STX5 IDH3G PEX2 SGTA GDAP1 GFER VAPA ATP5MC1 TOMM7 TOMM5 TOMM6 ACOT8 UBB ATP5F1A CHCHD3 EHHADH HSD17B4 SAMM50 ACAA1 UBC ATP5F1B PECR DECR2 PEX10 ZFAND6 ABCD1 RPS27A PEX12 SLC27A2 IDE PEX13 ACOT4 CROT PEX14 PEX26 SCP2 NUDT19 MPV17 HSPA9 GSTK1 PHYH ECH1 MTX1 PIPOX ABCD2 ABCD3 PEX1 MTX2 BAAT PEX7 ACOX2 PEX3 ACOX1 PEX6 AGPS ACOT2 SEC61G ACOX3 SEC61B AGXT PAOX DDO HACL1 HAO1 HAO2 IDH1 NOS2 EPHX2 TYSND1 LONP2 DHRS4 NUDT7 OTOF AMACR DAO CRAT COQ2 GRPEL1 PRNP HSPD1 PEX19 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP83 CEP89 CEP57 CLASP1 YWHAE C2CD3 CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CDK1 B9D2 CEP290 NINL CC2D2A RAB8A OFD1 CPAP IQCB1 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 TMEM216 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 CEP152 CCP110 CEP250 CSNK1E SCLT1 CEP97 RAB11A CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D CEP162 TUBA1A B9D1 RPGRIP1L CEP41 CEP43 YWHAG FBF1 TTBK2 CEP70 NPHP1 CEP72 DYNLL1 CEP192 NPHP4 HSP90AA1 CKAP5 MARK4 CEP76 CEP78 PLK4 MAPRE1 ODF2 RAB3IP TUBB4B PAFAH1B1 TUBB4A DYNC1I2 AHI1 MKS1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 CYP2U1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity SMAD7 TRIM33 UBA52 UBE2D1 NCOR2 PPM1A RNF111 UBB UBC RPS27A USP9X SKI NEDD4L HDAC1 ATP1B4 MAPK1 WWTR1 PARP1 NCOR1 UBE2D3 MAPK3 SNW1 SKIL SMAD2 SMAD4 TGIF1 SMAD3 SMURF2 TGIF2 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition FBXO5 PLK1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes GSK3A PLA2G4B DNAJB11 LMNA SULT1A3 HYOU1 EXTL2 PREB EXTL3 GOSR2 ADD1 FKBP14 MYDGF TATDN2 CUL7 SERP1 SEC31A GFPT1 TSPYL2 DDX11 WIPI1 PDIA6 PDIA5 ATP6V0D1 SYVN1 PPP2R5B CTDSP2 KDELR3 SHC1 DCTN1 CXXC1 EXTL1 SSR1 ARFGAP1 DNAJB9 ZBTB17 KLHDC3 DNAJC3 WFS1 EDEM1 YIF1A TLN1 SRPRA ACADVL SRPRB TPP1 HDGF MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal MGMT LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation FCN3 MASP1 MBL2 COLEC11 COLEC10 FCN1 FCN2 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation JAK1 MAPK1 MAP2K2 IL6R JAK2 PTPN11 IL6 TYK2 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGF NGFR DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE MTRR MTR SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SLC24A4 CALM1 SLC24A2 SLC24A5 SLC24A3 SRI BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism MCCC2 SLC25A44 MCCC1 BCAT2 GLYAT PPM1K AUH IVD HIBCH ECHS1 HSD17B10 ACAT1 BCKDK BCKDHA DBT BCKDHB DLD ACAD8 HIBADH ACADSB ALDH6A1 CRAT BCAT1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 GNA14 PLA2G4A GNGT1 GNA15 GNA11 GNAQ P2RY1 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 MAPK14 GNB4 GNB3 GNB5 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis ST3GAL1 CHST5 ST3GAL2 ST3GAL3 CHST2 OGN CHST3 OMD B4GALT2 B4GALT3 B4GALT1 SLC35D2 B3GNT3 FMOD ST3GAL6 B4GAT1 B4GALT6 KERA B4GALT4 B4GALT5 CHST6 PRELP ACAN B3GNT7 B3GNT4 LUM CHST1 B3GNT2 ST3GAL4 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin MAOA ALDH2 SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy ATM PRKAG1 HSF1 PRKAG2 TOMM40 DYNC1I1 UBA52 DYNC1H1 PRKAG3 MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN UBC RPS27A MAP1LC3A FUNDC1 USP30 ATG9A VDAC3 ATG12 VDAC2 PEX5 ATG5 NBR1 VDAC1 UBE2D2 SQSTM1 PLIN3 ULK1 HSPA8 TBK1 VCP UBE2V1 DYNC1LI1 DYNC1LI2 PCNT PRKAB2 IFT88 TOMM70 CSNK2A1 CSNK2A2 TOMM20 UBE2L3 PRKAB1 TOMM22 CSNK2B UBE2N ARL13B EPAS1 MTERF3 DYNLL1 CETN1 PARK7 HSP90AA1 PRKAA2 DYNLL2 HDAC6 UBE2D3 PLIN2 CFTR PRKN DYNC1I2 PINK1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification SERPINA1 PPP6C TFG PPP6R1 PPP6R3 TMED2 CTSC TRAPPC2L LMAN1L MAGT1 F5 F8 TRAPPC6A TBC1D20 USP34 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 B3GNT3 LMAN2 CD59 SEC31B SEC31A DERL1 ANKRD28 DERL2 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 SEC16A TRAPPC10 OS9 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 SUZ12 H2BC9 CNIH3 H2BC8 FOLR1 NEDD8 H2BC5 BET1 CAND1 H2BC3 H2BC1 TUSC3 CP TF H2AC8 H2AC6 H2AC7 TMEM258 RNF139 UGGT2 VCP UGGT1 MARCHF6 EDEM3 SEL1L AMFR RNF103 TRIM13 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 DBT H2BC26 H2BC21 WDR5 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 COL7A1 RNF5 RBBP5 RBBP7 DCAF13 PCSK9 ELOB ELOC APOA2 APOA5 CD109 TAF10 RAB27B CALU GPIHBP1 ACTB QSOX1 DCAF7 ALB P4HB AHSG TUBB6 ADRB2 TUBB3 TUBB1 FBXO4 SPP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 APLP2 TP53 SCG3 SDC2 FBXL3 FBXL5 MMRN1 TUBA1C XRCC4 TUBA1B TUBA1A ST3GAL6 BAP1 B4GALNT2 UBXN1 TUBB2B UCHL1 TUBB2A SENP8 UCHL3 B4GAT1 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A B3GNT7 NUP205 B3GNT4 POM121 NUP188 B3GNT2 AAAS POM121C NUP42 NUP62 TPR NUP88 RAE1 SUDS3 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 GPC3 NUP50 NUP35 SLC17A5 GOLGB1 NUP54 ALG11 PDIA6 RPL8 KDELR3 DCTN1 FUT3 WFS1 EDEM1 USP10 MANEA RPS6 B4GALT2 B4GALT3 B4GALT1 HK1 TGFB1 EIF2AK2 OTULIN USP17L2 RCE1 RPL27A CALR B4GALT6 RPS23 B4GALT4 B4GALT5 ST6GALNAC6 PARP1 DNAJC3 CANX RPS2 CDC73 RNF152 ALG14 SHPRH ALG13 HLA-B PEX2 RNF40 RNF144A SKIC8 SELENOS WAC CTR9 TRAF3 RTF1 IKBKE TMEM129 HLTF LEO1 PEX10 PEX12 PEX13 PEX14 VNN1 PAF1 RNF181 VNN2 PROS1 ATXN3L MTA1 JOSD2 JOSD1 TOPORS TNFAIP3 GAS6 LY6E OTUD7B USP21 USP4 CYLD MGAT3 GALNT1 RAB27A U2AF2 TDG TTLL10 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 ANO8 AGBL3 TTLL1 AGBL2 GALNT11 TTLL13 GALNT14 TTLL11 GALNT13 TTLL12 GALNT16 TTLL9 GALNT15 TTLL8 LAMB2 GALNT18 GALNT17 GALNT10 FN1 GALNT9 GALNT8 LAMB1 B3GNT9 LAMC1 QTGAL B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 HLA-A GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT PSMD9 GALNTL5 RAB2A PSMD4 GALNTL6 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 FOXL2 PSMD10 PSMB11 HIC1 SP3 POMP PSMB10 PSMA8 VDAC3 PSMF1 VDAC2 PSMB8 PSMB9 PSMG3 PSMG4 PSMG1 VDAC1 PSMG2 UBE2D2 CDC34 CDH2 RHOA BMP4 TOMM20 UBE2N TAB1 PARK7 RAB10 RAB14 RAB13 CFTR TRAF6 ARFGAP3 AXIN2 RAB7A MGAT5B CSF1 LMAN1 STX5 YKT6 KTN1 MITF USP30 PGAP1 HDAC1 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 RHOT1 B3GALNT2 FUCA1 LYPD6B PIGS PIGU PIGT PIGO PROC PIGN PIGP TNC PIGZ PIGW PIGV PIGY PIGX GMPPB PMM1 CHST8 IFIH1 CRPPA RNF135 GMPPA PMM2 PIGC TRIM25 CGA PIGB MPI PIGA PTRH2 PIGK PIGM FBN1 PIGL MAVS PIGG PIGF RIGI DAG1 ARF5 PIGH ARCN1 ETFBKMT RAB5B LY6K RAB5C POFUT4 DPAGT1 POFUT2 ALG8 POFUT3 ALG9 RAB5A LY6D ALG6 LY6H ALG2 ATXN7 ALG3 SPRN ALG12 ETFB ALG1 FCGR3B MPDU1 SPACA4 RFT1 MDGA2 RECK MDGA1 KDELR2 GPS1 NRN1 ART3 ART4 SNX3 NTNG1 NTNG2 CUL2 BST1 GPAA1 OTUD7A MIA2 RNF20 RAB22A CD52 KIN USP33 STAMBPL1 NDUFAB1 ENGASE COPS4 ETF1 OTUD5 COPS2 RXYLT1 PRND EMID1 VCPIP1 CNTN5 HNRNPC UBE2T ST6GALNAC1 ALPL CNTN3 CMAS NANP CNTN4 ALPG FPGT PGM3 NGLY1 MYSM1 GNPNAT1 NANS VCPKMT MMRN2 GFUS NUDT14 OTUB1 ST6GAL2 OTUB2 TEX101 SLC35C1 ALG5 GOSR1 FURIN RAB40A RENBP DHDDS RAB40B RAB40C DPM1 TNIP1 DPM2 TGFBR1 TNIP3 DPM3 TGFBR2 ST6GALNAC5 GCSH USP17L4 GNE UAP1 USP17L5 USP17L8 NPL FUOM RNF128 NEU2 ALG10B NEU3 GPLD1 NEU4 LIPT2 LIPT1 DHRSX CHST10 RRAGA GMDS AMDHD2 GP2 NEU1 TADA2B ST8SIA4 ASGR1 ST8SIA5 PRSS21 ST3GAL5 ASGR2 ST8SIA6 COPZ2 CTSA COPZ1 WDR20 NUS1 METTL21A SLC35A1 ST8SIA1 USP17L3 ST8SIA2 USP17L1 GFPT2 PRSS41 ST8SIA3 EEF1AKMT2 SRD5A3 EEF1AKMT1 GFPT1 RAB3B DOLK RAB3C NAGK RAB3D RAB44 FCSK RAB41 DOLPP1 RAB42 LARGE2 VGF TECTA TECTB RAB2B DCAF8 USP5 DCAF5 USP3 DCAF4 RAB30 DCAF6 RAB36 WSB2 RAB37 APC SQSTM1 RAB34 OBSL1 FKBP8 DCUN1D5 STAMBP DCUN1D3 RAB4B DCUN1D4 PLET1 DCUN1D1 ARF1 CPM DCUN1D2 COMMD8 CTSZ PSCA COMMD9 RTN4RL2 BET1L PUM2 HIF3A PTP4A2 DDA1 MVD METTL22 RTN4RL1 ANKRD9 SEC23A COMMD2 RAB20 COMMD3 RAB25 POMT2 COMMD1 RAB26 SAR1B COMMD6 SEMA5A RAB23 COMMD7 RAB24 GALNT12 HSPA8 SPON2 COMMD4 RAB29 COMMD5 SEMA5B EEF2KMT SPSB3 SPON1 FKTN CCDC8 THSD7B SLC35A4 POMT1 CUL9 FKRP ADAMTS4 RAB15 UBD NAE1 ADAMTSL1 RAB19 SOCS6 MBTPS1 RAB17 SEC24B WDTC1 ADAMTS5 FOLR2 SOCS5 SEC24A C1GALT1C1 NFU1 CCDC22 ADAMTS2 USP17L30 COMMD10 ADAMTS3 YOD1 ADAMTSL5 TULP4 UMOD ADAMTSL4 DCAF16 LIAS MAT2B ADAMTS1 DCAF17 OTOA FEM1C ADAMTSL3 MLEC ADAMTSL2 DCAF10 ZRANB1 MUC12 DCAF11 RAET1G FEM1A MUC13 RAET1L FEM1B SEC24D THSD7A TMED3 SEC24C MUC15 TMED7 NEURL2 ERCC8 ADAMTS8 TMED9 LARGE1 IZUMO1R ADAMTS9 CEACAM7 ADAMTS6 NRN1L ADAMTS7 CEACAM5 SBSPON USP17L21 MUCL1 USP17L20 USP17L22 POMGNT1 MUC3A LY6G6C MUC5AC LY6G6D MUC3B USP17L15 ADAMTS20 USP17L18 B3GLCT UBE2L3 USP17L17 CFP USP17L19 FGF23 LSAMP THBS2 ADAMTS12 USP17L10 THSD1 USP17L12 THSD4 USP17L11 ADAMTS10 USP17L13 ADAMTS16 COPG2 ADAMTS15 COPG1 ALG10 MUC1 ADAMTS14 COPB2 ADAMTS13 COPA TRAF2 NTM MUC2 ADAMTS19 COPB1 ADAMTS18 MAN2A2 ADAMTS17 TMEM115 ULBP2 MUC7 COPE MUC4 USP37 MUC6 GALNT3 USP47 MUC16 USP48 MUC17 USP49 C1GALT1 USP42 BIRC2 MUC19 USP44 BIRC3 SSPOP PLAUR PRKN MUC5B POMGNT2 MUC20 USP16 MUC21 USP12 LRR1 RIPK1 ABRAXAS2 CCNF USP19 KEAP1 OPCML USP24 USP25 USP26 NEGR1 USP20 USP22 USP28 HERC2 XPNPEP2 POMK FBXO7 OGT FBXO9 WSB1 DLAT FBXO2 RNF123 UBE2J2 SIAH2 FBXL8 FBXL4 FBXL7 TRIM4 SERPINC1 LRRC41 GAN MFGE8 KLHL2 WDR48 CST3 UBE2G1 KLHL3 UBE2B UBE2G2 CUL4A F2 DDB1 KLHL9 SPSB2 DTL SPSB1 RAD18 CUL4B KBTBD6 KLHL5 KBTBD8 SPSB4 FBXO27 FBXO21 UBE2Z FBXO22 ASPH FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 KNG1 FBXO11 KLHL41 KCTD7 KLHL42 UBE2V2 CUL7 CUL5 UBA6 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W IGFBP7 ARF3 DLST UBA3 CBX8 PHC2 UBA1 PHC1 UBE2K CBX4 UBE2M CBX2 AMER1 KDM8 STS PHC3 KBTBD13 OGFOD1 EIF5A ARSA UBE2Q2 JMJD4 DHPS IL6 FN3KRP MDM2 JMJD7 SUMF2 MDM4 SUMF1 BMI1 UBE2R2 JMJD6 TPST2 F7 TPST1 RING1 F9 ASB13 ASB14 RCCD1 ASB11 EIF5A2 PROZ CCNA2 ASB12 DNAJC24 ARSL CCNA1 RNF7 DPH1 ARSJ ASB17 DPH2 ARSK ASB18 RNF2 FBXL22 DPH3 ARSH ASB15 ARSI FBXL21P ASB16 DPH5 ARSF FBXL20 DPH6 ARSG DPH7 ARSD CDKN2A ZC3H15 ASB10 RWDD1 VHL FN3K ICMT F10 DOHH FBXL19 RIOX1 FBXL18 GGCX FBXL15 RIOX2 FBXL16 FBXL13 DRG1 FBXL14 DRG2 FBXL12 ASB8 ASB9 ASB6 AREG ASB7 FSTL1 CHRDL1 ASB4 EEF1A1 ASB5 ASB2 ASB3 EEF2 ASB1 ADAM10 CTBP1 C3 C4A ARFGAP1 ALPI CKAP4 H2BC18 DNMT3B COP1 BECN1 DNMT3A DNMT1 IDE IL33 POLB ST6GALNAC2 PRKCSH FUT8 GANAB MAN2A1 MGAT5 CISH ST3GAL4 MGAT1 MGAT2 ST3GAL1 SOCS2 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C MGAT4A MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 ARFGAP2 MDC1 KDELR1 NLRP3 UFD1 TRIM27 USP13 TNKS TNKS2 RNF146 GATA3 OTUD3 MAN1A2 MAN1C1 MAN1A1 HNRNPK NPLOC4 RAB32 RAB31 RAB38 ACTL6A NSF DDB2 RAB21 GRIA1 CHML RAB39A RAB39B RAB12 RAB18 BGLAP SPP1 USP9X TOMM70 TADA3 PDIA3 PNPLA2 UBE2D3 PSMD8 PSMD6 YY1 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 RIPK2 DCTN5 BCL10 PSMA7 DCTN4 RELA PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SMC5 RPS27A SMC6 DDX17 ADRM1 NSMCE3 NSMCE2 SEM1 NSMCE1 NFKBIA MRTFA PSMC5 EID3 PSMC6 PSMC3 ZBED1 PSMC4 UBA2 PSMC1 SAE1 PSMC2 FOXO4 TOP2A USP14 TOP2B ZNF131 ATXN3 SENP5 SOCS3 SENP2 NOD1 SAFB PIAS4 NOD2 SENP1 NSMCE4A HDAC4 PIAS3 TOP1 USP18 SP100 THRB UHRF2 UBE2I SATB1 VDR CASP8AP2 NR1H2 RORA NOP58 NR3C1 TNIP2 RWDD3 MBD1 NR2C1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA FBXO32 BRCA1 CCP110 PTEN CSNK1D RABGGTB RABGGTA BLM UBXN7 PCNA WRN MUL1 DPP3 BARD1 RPA1 PALB2 ARF4 CETN2 UBE2C UBE2E1 UBE2D1 TRIM28 ACTR1A UBE2S CDK1 STAM RAB8A HGS L3MBTL2 TGFA STAM2 APOE SATB2 DCTN2 DCTN3 NPM1 GBF1 RAB11A NRIP1 EP300 APOB PPARGC1A TFAP2B NCOA1 TFAP2C NCOA2 CREBBP APOA1 CHD3 NFE2L2 RAB43 COG8 COG7 COG6 AURKA COG5 INS COG4 CALM1 COG3 COG2 COG1 APP NAPA NAPB CDC25A NAPG GOLGA2 TGOLN2 RAB6A RAB6B TUBB8 RAB9A TUBB8B RAB9B RBX1 RAB8B RAB4A RAB33A RAB33B RAB11B RAB35 RAB7B CHM ING2 NCOR2 KAT2B KAT2A ZNF350 CD55 SYVN1 PCGF2 DDX5 HIPK2 KDM1B ANK2 CUL3 ANK3 ANK1 MEN1 IGFBP1 KBTBD7 USP7 SPTBN4 SPTBN5 SPTA1 IGFBP3 USP2 SPTBN1 SPTBN2 VCAN GLB1 ARSB CDKN1A SPTAN1 CAMKMT SPTB SKP2 DAXX NUP107 SMC3 CDC20 LHB DYNC1LI1 DYNC1LI2 PENK CDCA8 NUP160 NUP85 RAD21 SIN3A RAB3A STAG1 STAG2 SEC13 NUP133 HDAC2 DYNLL1 SMC1A RUVBL1 RANGAP1 NFRKB DYNLL2 ACTR5 INCENP HDAC7 RAD23A BIRC5 ACTR8 RAD23B INO80C INO80B INO80E DYNC1I2 INO80D COPS7B AURKB COPS7A XPC PML TFPT MCRS1 NUP43 INO80 COPS3 COPS6 DYNC1I1 COPS8 RANBP2 DYNC1H1 NUP37 KCTD6 CAPZB SMAD2 SMAD1 SMAD4 SMAD3 BRCC3 CBX5 SMURF2 CAPZA1 CLSPN TP53BP1 CAPZA2 BABAM1 BABAM2 TIMP1 UIMC1 SMAD7 RNF168 ABRAXAS1 DMP1 LGALS1 EVA1A RAD52 CCN1 CHGB IGFBP5 IGFBP4 SHISA5 H2AC17 MXRA8 H2AC12 AXIN1 SPARCL1 FDX1 PRMT3 H2AC1 SCG2 USP15 H2AC19 H2AC25 STC2 H2AC14 H2AC21 AMELX AMBN MYC TMEM132A LTBP1 FUCA2 THBS1 BPIFB2 HRC MELTF HSP90B1 SERPINA10 UCHL5 MIA3 MSLN PRSS23 USP8 BMP15 MEPE RCN1 ENAM RPN2 EPAS1 AMTN FAM20C RPN1 VWA1 ARRB1 FAM20A MATN3 ARRB2 ITIH2 HIF1A AFP FSTL3 APOL1 SERPIND1 FGA GOLM1 NUCB1 FGG NOTUM H4C9 PRKDC TRRAP H2AC20 MCFD2 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MT-CYB MT-ND6 MT-ND4L MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 MTRF1 GFM2 MRRF MTRF1L MT-ATP6 MT-ATP8 MT-CO1 MT-CO2 MRPS17 MT-CO3 MRPS15 MRPS16 MRPS14 MRPS11 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA8 IFIH1 IFNAR1 TRIM25 IFNA21 IRF3 IFNA14 IFNA16 IFNA17 MAVS UBA52 IFNA10 RIGI ELOB ELOC TYK2 JAK1 STAT2 UBB UBC EIF2AK2 RPS27A CUL5 EP300 RBX1 IFNB1 CREBBP IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis PLD4 AGPAT5 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 PLA2G4B HADHB PLA2G2A ABHD3 HADHA DDHD2 PCTP DDHD1 GNPAT CEPT1 MFSD2A LPCAT4 PLA2G10 PCYT1B GPD1 CHKB PCYT1A GPD1L PLA2R1 CHKA STARD10 PHOSPHO1 PEMT CHPT1 GPAM ACHE BCHE CHAT PNPLA2 ALPI PITPNB TAFAZZIN AWAT2 PLD1 LPGAT1 CPNE7 CPNE6 CPNE1 CPNE3 PCYT2 PISD PLA2G15 SLC44A5 PGP PLA1A ABHD4 SLC44A3 PGS1 SLC44A4 PTPMT1 SLC44A1 OSBPL8 SLC44A2 OSBPL5 DGAT2L6 CRLS1 CDS2 OSBPL10 PLAAT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 GPAT2 DGAT2 PTDSS2 SELENOI PTDSS1 MBOAT1 DGAT1 ETNPPL ETNK2 ETNK1 PNPLA3 GPD2 MBOAT7 LPIN1 STARD7 LPIN2 MGLL LPIN3 PLA2G3 PLA2G6 PLB1 PLA2G4F CDS1 TMEM86B PLA2G4E PITPNM1 PITPNM3 PNPLA8 PLA2G4C PITPNM2 AGK CDIPT MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 PLA2G4A CSNK2A1 CSNK2A2 PLD3 CSNK2B PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK10 KCNJ2 KCNK13 KCNK16 KCNJ4 KCNK17 KCNK18 KCNK5 KCNK12 KCNJ14 KCNK15 KCNK6 KCNJ12 KCNK2 KCNK7 KCNK1 KCNK3 KCNK4 KCNK9 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks ATM MRE11 RAD50 KAT5 KPNA2 NBN INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic COG7 GOSR1 COG6 COG5 COG4 COG3 COG2 COG1 RAB39A NAPA NAPB STX16 VPS45 NAPG STX5 YKT6 GOSR2 VTI1A STX6 TRIP11 RIC1 MAN1A2 RGP1 MAN1C1 MAN1A1 RAB41 RAB30 RAB36 MAN2A2 ARF1 GOLIM4 CYTH3 CUX1 RAB33B CYTH2 BET1L GOLGA5 CYTH4 SNAP29 CYTH1 NSF ALPP MAN2A1 COG8 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases ASCC2 ASCC3 ALKBH2 ALKBH3 FTO ALKBH5 ASCC1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling EREG BTC PIK3CA PIK3R1 NRG1 NRG2 HBEGF NRG3 NRG4 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR PDHX PDHA2 PDHA1 DLD DLAT PDHB SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism SFTA3 DMBT1 LMCD1 NAPSA CCDC59 SFTPC ADA2 PGA3 SFTPB PGA5 ABCA3 PGA4 ADGRF5 SFTPA1 SFTPA2 ADRA2C ADRA2A GATA6 TTF1 SLC34A2 ADORA2A P2RY2 SLC34A1 ADORA2B CTSH CSF2RB CSF2RA SFTPD ZDHHC2 CKAP4 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins ISCU CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import PEX26 ACBD5 ABCD2 SLC25A17 ABCD3 ATAD1 PEX11B PEX16 PEX3 PEX2 GDAP1 FIS1 PXMP2 PEX19 PXMP4 PEX12 ABCD1 PEX13 PEX14 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling PPP1CC SHOC2 ARAF PPP1CB RAF1 BRAF YWHAB MRAS DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis CSPG5 CSPG4 NCAN BGN UST DSE DCN BCAN VCAN CHST15 DSEL CHST14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 HBB IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 APOA1 IGLC2 HBA2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 LRP1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 ALB HP HPR HPX IGHA1 IGHA2 AMBP JCHAIN CD163 APOL1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis GSDMD GZMB NMT1 YWHAE CYCS SFN BAX C1QBP GSDME BCL2L11 CASP7 TP53BP2 YWHAH YWHAZ MAPK8 BBC3 CDKN2A YWHAB E2F1 CASP3 MAPK1 STAT3 TFDP1 MAPK3 TFDP2 TP73 PMAIP1 BCL2 BCL2L1 TP53 AVEN DIABLO CARD8 UACA PPP1R13B BID AKT2 AKT3 BAD CASP9 AKT1 APAF1 CASP8 YWHAG PPP3CC BMF TP63 DYNLL1 DYNLL2 APIP YWHAQ XIAP BAK1 PPP3R1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF4EBP1 EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 EIF5 RPS13 EIF5B RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 EIF2B5 RPL15 EIF2B4 RPS2 EIF2B3 RPL18 EIF2S3 RPL17 EIF2B2 EIF2B1 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis NFKBIA MAPKAP1 RICTOR RPTOR PIK3C3 NFKBIB BECN1 RETREG1 DAXX TAOK1 PRR5 PIK3R4 ATG14 RIPK1 MTOR MLST8 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic TMED2 ARF4 NAPA NAPB CENPE SEC22B NAPG RAB1A TMED10 COPZ2 COPZ1 RAB1B KIF4B KIF4A KIF20A KDELR3 KLC1 KLC4 KLC3 KLC2 KIF11 KIF15 ARF1 KIF23 KIF22 NSF KIF26A ZW10 ARF5 KIF5C ARCN1 KIF5B KIF5A GBF1 TMED3 KIFAP3 TMED7 KIF28P TMED9 KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KDELR2 KIF18A KIF6 KIF27 RINT1 ARFGAP2 KIF9 KIFC2 KIF16B KIFC1 KIF20B KIF3B KDELR1 NBAS KIF3A COPG2 STX18 COPG1 BNIP1 COPB2 SURF4 COPA KIF18B KIF26B COPB1 KIF3C ARFGAP1 COPE KIF2A KIF2C KIF2B RACGAP1 ARFGAP3 ARF3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins SCN11A SCN9A NRCAM SCN1B SCN1A ANK2 ANK3 ANK1 SCN10A SCN8A KCNQ2 KCNQ3 SPTBN4 SPTBN5 SPTA1 SCN3B SCN3A SPTBN1 SPTBN2 L1CAM SCN2A SCN2B SCN5A SPTAN1 SPTB SCN4A SCN4B SCN7A NFASC MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL TUBGCP2 TUBGCP5 TUBGCP6 OFD1 TUBGCP3 CPAP TUBGCP4 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK6 KCNK2 KCNK7 KCNK10 KCNK1 KCNK3 KCNK4 KCNK9 KCNK13 KCNK16 KCNK17 KCNK18 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair RAD1 ATM RAD9B ATR H2AX RAD9A LIG1 CCNA2 CCNA1 RNF4 H2BC9 H3-4 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CDK2 SIRT6 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PARP1 PARP2 ERCC4 HERC2 ERCC1 UBA52 UBB UBC RPS27A FEN1 SEM1 PIAS4 UBE2I XRCC1 LIG3 PPP4R2 TIPIN TIMELESS BRCC3 PPP4C CLSPN TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 MUS81 RNF8 MRE11 NSD2 BRCA1 RAD52 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE POLH GEN1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 UBE2V2 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 POLQ MDC1 RHNO1 BLM RTEL1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 H4C9 XRCC2 XRCC3 RPA1 RPA2 PALB2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism PCCB MMUT MCEE PCCA MMAA DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation MET HGF MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins PPP1CC CSNK2B FURIN SPCS3 PPP1CB SPCS2 SPCS1 SEC11A SEC11C PPP1CA KPNB1 XPO1 CSNK2A1 CSNK2A2 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 CDC20 FBXO5 CDK1 PLK1 FZR1 CCNB1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery POLR2I POLR2J POLR2K POLR2L CCNK CCNT2 ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production TNFRSF1A SMPD3 SMPD2 RACK1 TNF NSMAF ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism GOT2 FOLH1 FOLH1B GADL1 ASPG NAALAD2 NAT8L ASNS SLC25A12 ASPA SLC25A13 GOT1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription FURIN SMAD7 CDK8 CCNK CCNT2 CCNT1 CCNC UBA52 MEN1 SERPINE1 YBX1 SP1 JUNB RBL1 RNF111 COL1A2 UBB MYC UBC RPS27A EP300 CDK9 CDKN2B HDAC1 E2F4 MAPK1 WWTR1 E2F5 MAPK3 TFDP1 TFDP2 SMAD2 SMAD4 TGIF1 SMAD3 TGIF2 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation JAK1 CDK1 MAPK3 MAP2K1 IL6R JAK2 PTPN11 IL6 TYK2 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor CALM1 NRAS CAMK2B RASGRF2 CAMK2D ACTN2 RASGRF1 CAMK2A GRIN2B HRAS GRIN2D DLG1 GRIN1 DLG3 DLG4 DLG2 LRRC7 NEFL CAMK2G EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere ACD DNA2 BLM PCNA LIG1 POLD3 POLD4 WRN POLD1 POLD2 TINF2 RPA1 RPA2 TERF1 TERF2 RPA3 POT1 TERF2IP FEN1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation PCSK9 AP2A1 AP2S1 AP2A2 UBA52 CLTC CLTA NR1H3 AP2M1 MYLIP AP2B1 VLDLR NR1H2 UBB UBC RPS27A LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis CD3G RAC1 VAV1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 IGHG3 IGHG4 IGHG1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 WASF3 MYO10 MYO1C RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab HSP90AA1 CDC37 ERBIN ERBB2 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs ALOX5 PTGS2 CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP1A2 LTC4S CYP1A1 CYP2E1 ALOX15 GSTM4 EPHX2 ALOX12 HPGD LTA4H EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination LAMA2 ADGRG6 LAMB1 LAMC1 EGR2 DAG1 CYP51A1 HMGCR TEAD1 PMP22 MAG NAB1 NAB2 YAP1 POU3F1 POU3F2 UTRN SOX10 MBP HDAC2 ADGRV1 WWTR1 SMARCA4 PRX SREBF2 DRP2 SCD5 MPZ SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK PTPN6 MYCN CD274 IL2RG JAK3 DNMT1 PTPRZ1 MDK HDAC3 ALK IRS1 PRDM1 MYC SIN3A PIK3CB EP300 PIK3R2 HDAC1 PIK3R1 PIK3CA HDAC2 HIF1A STAT3 PLCG1 PTN ALKAL2 FRS2 ALKAL1 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 HMGA1 PSIP1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance H2AX MTA2 H3-3B TBP H3C8 H2AJ RRN3 ERCC6 H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 MAPK3 CCNH MBD2 H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 KAT2B MNAT1 KAT2A H2AC19 H2AC14 H2BC12L MBD3 H2BC26 H2BC21 TTF1 GATAD2B UBTF GATAD2A H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 EHMT2 POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling CHUK NFATC3 NFATC2 FBXW11 NFATC1 PSMA5 PSMA6 CALM1 PSMA3 UBE2M PSMA4 PSMA1 PSMA2 UBA52 CARD11 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2D2 AHCYL1 CDC34 PLCG2 UBE2V1 SYK PRKCD NFKB2 ITPR1 ITPR2 MAP3K14 PYCARD ITPR3 CLEC7A CARD9 RELB CASP8 UBE2N TAB3 PDPK1 TAB2 TAB1 IL1B PSMD8 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PPP3CA PSMD3 PPP3CB PSMD1 IKBKG BTRC MAP3K7 SKP1 PPP3R1 UBA3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR HSP90AA1 GCHFR NOS3 CALM1 PTS SPR PRKG2 AKT1 GCH1 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity TNRC6A CALM1 TNRC6B PRKACA HTT NCOR2 CAMK2B CAMK2D HDAC3 CAMK2A SIN3A CAMK4 GPS2 CAMK2G LBR FOXG1 TBL1X HDAC1 HDAC2 NCOR1 HIPK2 TBL1XR1 MOV10 AGO3 AGO4 AURKB AGO1 AGO2 TNRC6C NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway CHUK ITCH UBE2V1 CASP2 RIPK2 CASP9 CARD9 AAMP CASP8 UBE2N TAB3 CASP4 TAB2 TAB1 IRAK1 CASP1 NOD1 NOD2 IRAK2 TNFAIP3 IKBKB BIRC2 TRAF6 BIRC3 CYLD MAPK14 IKBKG MAPK12 MAP3K7 MAP2K6 MAPK13 MAPK11 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling STAT4 JAK1 STAT5A STAT3 STAT5B IL21R IL21 IL2RG JAK3 STAT1 COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism MMUT MTRR MMAB MTR MMACHC MMADHC MMAA SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses POM121C NUP42 IFNAR1 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 TYK2 NUP50 JAK1 NUP35 NUP54 HLA-A B2M STAT2 ATG14 IFNB1 STAT1 TKFC SEC23A NUP107 SAR1B KPNA2 TBK1 IRF3 UBE2V1 SEC24B SEC24A NUP160 SEC24D SEC24C HLA-H HLA-C HLA-F NUP85 PIK3R4 HLA-G HLA-E ISG15 TOMM70 IL17RC IL17RA UBE2N TLR1 TAB3 TAB2 TAB1 IRAK1 TLR2 SEC13 NUP133 PIK3C3 CREBBP HSP90AA1 IKBKB TRAF6 IKBKG PTPN11 MAP3K7 CHUK PTPN6 NUP43 RANBP2 BECN1 HLA-B RIPK2 TRAF3 IKBKE NUP37 TRIM4 NOD1 NOD2 IRAK2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 LARP1 SIKE1 MAVS IFNA10 RIGI TLR8 TLR7 G3BP1 G3BP2 HSP90AB1 MASP1 MBL2 CNBP NLRP3 IRF7 SFTPD NLRP12 NUP205 POM121 IL17F NUP188 IL17A STING1 AAAS SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DOLK DOLPP1 DHDDS NUS1 MVD SRD5A3 DHRSX CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation NFATC3 NFATC2 NFATC1 ITPR1 CALM1 ITPR2 ITPR3 PPP3CA PPP3CB AHCYL1 PPP3R1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation MCM6 MCM2 H2AX ANAPC15 ANAPC16 KPNA1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 H3-3B CDC16 ANAPC4 ORC5 H3C8 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 H2AJ ORC3 ORC2 H3C15 FZR1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 CDC6 KPNB1 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 KPNA6 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 MCM10 PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PSMC1 RPA4 PSMC2 CDC7 POLE H2AC19 H2AC14 H2BC12L H4C9 RPA1 RPA2 CDC45 POLE4 MCM7 H2AC20 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGF9 FGF20 FGF23 FGF16 FGF18 FGFR3 FGF1 FGF2 FGF4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 CXXC4 DVL3 CCDC88C CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli BAG5 HSPH1 EZH2 DNAJB6 BAG3 H2AX HSF1 BAG1 HSPA4 ST13 HSPA7 HSPA6 HSPA12A HSPA12B PREB H3-3B H3C8 CHAC1 FOS GOSR2 TCIRG1 H2AJ ATP6V1E1 ATP6V1E2 YAP1 ATP6V0B ATP6V1G1 SEC31A ATP6V0E1 ATP6V1G2 H3C15 NOS3 ATP6V1B2 ATP6V0D1 RICTOR ATP6V0C ATP6V0D2 ABCG2 ATP6V1B1 SUZ12 H2BC9 ATP6V1A H2BC8 H2BC5 STAT1 H2BC3 STAT3 ATP6V1H H2BC1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 H2AB1 H2AC8 H2AC6 H2AC7 VCP EPO CA9 HIGD1A PRR5 GSK3B PIK3CD PIK3CB H2BC26 H2BC21 MLST8 EED PDPK1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA H2BC11 PRKAA2 RBBP4 FYN RBBP7 PKN2 H2AZ2 MTOR TNRC6C TNRC6A TNRC6B CREB3L3 PRKACG PRKACB ELOB ELOC KDR PTK6 GJA1 ALB P4HB IDH1 TP53 TALDO1 HSPG2 GNAQ PECAM1 STIP1 GNA11 NUP205 POM121 NUP188 AAAS POM121C NUP42 SZT2 SAMTOR NUP62 TKT SEH1L TPR NPRL2 NPRL3 NUP88 RAE1 GCN1 WDR59 EIF2AK4 NUP214 NDC1 FLCN NUP210 MIOS EXTL2 NUP155 ITFG2 IMPACT HMGA1 NUP153 KPTN DEPDC5 NUP93 NUP50 WDR24 SH3BP4 NUP35 NUP54 FNIP1 FNIP2 KICS2 CASTOR1 EXTL3 CASTOR2 ADD1 FKBP14 HERPUD1 MYDGF PANX1 TATDN2 SERP1 CREB3L4 CREB3L1 RPL4 CREB3L2 RPL5 TSPYL2 RPL30 DDX11 RPL3 WIPI1 RPL32 PDIA6 RPL31 PDIA5 ERN1 RPL34 PGD CREB3 RPL10L RPL10A DCSTAMP RPL8 CTDSP2 KDELR3 RPL6 RPL7 ATF6B DCTN1 CEBPG RPS15 CXXC1 RPS14 EXTL1 RPS17 SSR1 RPS16 DNAJB9 RPL18A ZBTB17 RPS19 RPS18 KLHDC3 WFS1 RPL36AL EDEM1 RPL36 ASNS YIF1A RPL35 CREBRF RPL38 SRPRA SRPRB RPL37 TPP1 HDGF RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A DNAJC3 RPL37A EIF2AK1 ATF5 RPL10 TXN2 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 HSPA1A IKBKE HSPA5 ABCC1 GSK3A OMA1 PRKAR1A EIF2AK3 CACNG7 ATP7A TRPV4 STOML2 PHB2 YME1L1 UBE2D2 PLA2G4B ITGB1 MT2A MT1A MT1M MT1F MT1G MT1X MT1H MT4 MT1B MT3 MT1E DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS6KA1 HSPE1 FABP1 ID1 PPP2R2A PIEZO1 ITGAV ANXA2 PTK2 PRKAR2A GSTA1 HSP90AB1 CUL2 RPTOR FLT4 RRAGA RRAGC RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 GFPT1 LAMTOR3 LAMTOR5 CACNA1H SQSTM1 HIF3A MTF1 ACADVL HSPA8 MBTPS1 NFYA NFYB NFYC SP1 MBTPS2 IL1A KEAP1 CYCS TRIM21 HSPA9 PRKACA DEFA5 CAMK2B CAMK2D CAMK2A CAMK2G CUL7 EHMT2 EHMT1 ETS1 ETS2 P2RY2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 MAP2K4 TINF2 ERF MAPKAPK5 AJUBA TNIK ASF1A TXN EP400 IGFBP7 MAP2K7 NRF1 MAP2K6 DELE1 CBX8 HTRA2 CBX6 PHC2 DNAJA1 ACD DNAJA4 PHC1 LONP1 CBX4 CBX2 HMGA2 AMER1 H1-1 PHC3 H1-0 H1-3 H1-2 H1-5 H1-4 IL6 MDM2 MDM4 CXCL8 BMI1 CABIN1 VENTX KDM6B RING1 MINK1 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP CEBPB RNF2 HIRA MAPK9 MAPK8 MAPK7 UBN1 MAP4K4 CDKN2D CDKN2B CDKN2C CDKN2A IFNB1 VHL MAPK10 H3-4 EGF BCL2 PDGFA AREG BCL2L1 EEF1A1 NCF1 NCF2 NCF4 CYBB ARFGAP1 CYBA EIF2S3 EIF2S2 EIF2S1 MAP1LC3B FBXL17 SLC7A11 ADCY9 PRKAR1B PRKAR2B HYOU1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MT-CO1 NLRP3 UFD1 DDIT3 P2RX7 TXNIP MT-CO2 MT-CO3 DNAJB11 NPLOC4 HSPA1B BAG2 SIRT3 DNAJA2 SPP1 UBE2D3 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 SESN2 PSMD1 IKBKG BTRC SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SULT1A3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 CSRP1 PSMD13 SNCB DCTN6 PRKCI CUL1 DCTN5 PSMA7 DCTN4 RELA PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RORA NR3C1 ESR1 NR3C2 AR RXRA PGR PPARA MRE11 LMNA BRCA1 KAT5 NBN COX4I1 COX4I2 AQP8 NUDT2 ATF4 ARNT PRDX3 PRDX6 NOX5 UBXN7 GSTP1 NQO1 ITGA5 GSTA3 ERO1A SESN1 MUL1 DPP3 STAP2 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 GPX1 RPA1 GPX3 RPA2 GPX6 PTPN1 PALB2 GPX5 GPX8 GPX7 RAD50 BLVRB RPA3 BLVRA HM13 CCL2 ABCF2 TXNRD2 SOD3 ATM ATOX1 SOD1 ATR CCS ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ACTR1A ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CTNNB1 SHC1 MAPK1 MAPK3 COX7B CDH5 COX7C MAPK14 COX8A MAPK11 COX8C MAPKAPK3 MAPKAPK2 COX5B DCTN2 COX5A DCTN3 COX6C ATF2 VEGFA CRTC2 SLC46A1 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 LY96 COX6A1 COX6A2 HBB BACH1 NPAS2 G6PD HELZ2 RAI1 XPO1 PGRMC2 COX6B2 TGS1 COX6B1 NRIP1 HMOX1 EP300 ATF6 TBL1X APOB HIGD1C CLEC1B MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 APOA1 HBA2 NR1D1 SIRT1 HSPA1L NCOR1 TBL1XR1 CARM1 MAFK TLR4 BMAL1 CLOCK NFE2L2 HSPA2 CAT CALM1 YWHAE JUN SOD2 FOXO3 LMNB1 PRDX2 CAPNS1 CAPNS2 PRDX1 CAPN2 NOTCH1 RBX1 ADM GNGT1 GNGT2 RAMP2 CALCRL NCOR2 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 DCP2 NOX4 SYVN1 FKBP4 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 CUL3 IGFBP1 FKBP5 RB1 CDKN1A CDKN1B FZR1 E2F1 E2F2 E2F3 ABL1 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 NUP107 PPP2R1B PPP2R1A DYNC1LI1 CACNA2D1 DYNC1LI2 NUP160 NUP85 SIN3A GPX2 RPS27 CACNB1 CACNB2 CACNB3 SEC13 NUP133 PPP2R5B DYNLL1 DYNLL2 HDAC6 DYNC1I2 TXNRD1 PPP2CA NUP43 DYNC1I1 RANBP2 DYNC1H1 COX7A2L CITED2 NUP37 COXFA4 CAPZB COX7A2 COX7A1 LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP CAPZA1 CAPZA2 MMP14 PRKCD PPP1R15A H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 HSPD1 AKT1 HSP90B1 CSNK2A1 CSNK2A2 CSNK2B TRIB3 ATF3 ITGB3 EPAS1 MAPKAP1 PIK3R2 HIF1A GRB10 HSPB8 HIKESHI H4C9 CCAR2 HSBP1 DNAJC2 DNAJC7 TLN1 MOV10 CRYAB VCL AGO3 RPS19BP1 AGO4 HSPA4L H2AC20 HSPA14 AGO1 HSPA13 DNAJB1 BAG4 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency OTC VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 ELOB PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CUL5 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) SREBF1 TM7SF2 MSMO1 SREBF2 HSD17B7 NSDHL CYP51A1 DHCR24 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression GATA4 NKX2-5 TEAD1 HIPK1 TEAD2 KAT2B WWTR1 TEAD3 CCN2 HIPK2 TEAD4 NPPA TBX5 YAP1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKA PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 RB1 PSMC1 PSMC2 FZR1 SKP2 CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 AURKB PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis IMPDH2 GART PAICS PFAS ATIC PPAT ADSL GMPS ADSS1 IMPDH1 ADSS2 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions CD209 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 XDH BTN1A1 BTN3A3 BTN3A2 BTNL2 PPL HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state PSMA5 PSMA6 ITCH PSMA3 PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 IFT52 PRKACB PSMD11 GLI1 PSMD14 KIF7 PSMD13 GPR161 CUL1 INTU TULP3 PSMA7 FUZ ADCY10 PSMB6 PSMB7 PSMB4 PSMB5 IFT57 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 OFD1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 IFT140 PSMC1 PSMC2 NUMB WDR35 ADCY9 PRKAR1B SMO GLI3 PRKAR2B GLI2 PRKACA ADCY4 ADCY3 IFT172 ADCY2 ADCY1 WDR19 ADCY8 ADCY7 ADCY6 PRKAR2A CSNK1A1 DYNC2H1 ADCY5 GSK3B PRKAR1A RPGRIP1L IFT88 KIF3A TTC21B PTCH1 SUFU PSMD8 PSMD6 PSMD7 PSMD2 IFT122 PSMD3 GNAS PSMD1 BTRC MKS1 SKP1 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways POM121C NUP42 NUP62 NUP43 TPR NUP88 GBP1 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 CPSF4 MLKL EIF2AK2 ISG15 NUP37 SEC13 NUP133 KPNA7 KPNA4 NUP205 KPNA5 POM121 NUP107 NUP188 PABPN1 KPNA2 AAAS KPNA3 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases NHERF4 GUCY2C TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CALM1 PRKACG PRKACB FLT4 CAPNS1 CAPNS2 CAPN2 PANX1 CTNNB1 KDR NOS3 RICTOR ADM GNGT1 GNGT2 CDH5 ADCY9 PRKAR1B PRKAR2B RAMP2 PIEZO1 PRKACA CALCRL MMP14 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GNAQ ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ADCY5 GNG2 PRR5 PECAM1 GNG5 GNG4 PIK3CD GNG7 PRKAR1A GNG8 PIK3CB AKT1 MLST8 PDPK1 MAPKAP1 PIK3R2 PIK3CA P2RY2 GNA11 GNG12 GNG11 GNG13 FYN GNB2 TLN1 VCL GNB1 GNAS PKN2 GNB4 GNB3 TRPV4 GNB5 MTOR RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHCG RHBG RHAG B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2AX H3-3B TBP H3C8 MYBBP1A H2AJ ERCC6 H3C15 SF3B1 H2BC9 H2BC8 H2BC5 H2BC3 ACTB H2BC1 H2AB1 POLR2E POLR2F H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L KAT2B KAT2A H2AC19 H2AC14 H2BC12L GSK3B SMARCA5 H2BC26 H2BC21 BAZ1B EP300 DEK H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 H2AZ2 H2AC20 DDX21 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells DPPA4 ZIC3 SALL4 EPAS1 NANOG EPHA1 POU5F1 STAT3 SALL1 HIF3A SMAD2 FOXD3 PRDM14 SOX2 PBX1 LIN28A SMAD4 NR5A1 ZSCAN10 CRIPTO FGF2 KLF4 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression NOTCH1 EP300 RELA MAFK MYC NFE2L2 CREBBP NFKB1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants NOTCH1 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 ADAM17 NEURL1 MIB2 UBB UBC RPS27A DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors MCCC2 MCCC1 GSTO2 DHFR2 PRSS1 NADSYN1 FLAD1 CTRB2 CTRB1 SLC5A8 BTD MTHFD1 NOS3 MTHFD2 MTHFD2L SHMT1 HLCS SLC19A3 PNPO SLC19A1 SLC19A2 CBLIF MTHFR APOE MTHFS TCN1 CD320 MOCS2 MOCS3 QPRT THTPA SLC22A13 NMRK2 RFK NMRK1 CD38 VKORC1 MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 ACO1 NMNAT1 VKORC1L1 ALDH1L1 ALDH1L2 NUDT12 SLC25A51 UBIAD1 NADK SLC52A2 SLC52A3 SLC52A1 GPHN NADK2 NAPRT ACP5 AOX1 SLC46A1 SLC25A19 PDXK NAXE SLC25A32 NAXD APOB APOA1 LRP2 CLPS PNLIP CALM1 LRP1 LRP8 SHMT2 LDLRAP1 NAMPT CUBN AMN APOA2 BCO2 APOA4 BCO1 LPL LDLR GPIHBP1 APOC3 APOC2 IDH1 PTS SPR PDSS2 PDSS1 GCH1 STARD7 COQ9 COQ7 COQ6 COQ5 GCHFR PLB1 COQ4 HPDL COQ3 COQ2 COQ8B COQ8A APOM HSPG2 SDC4 SDC2 SDC3 AKR1B10 NT5E SDC1 BST1 DHFR GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN ACACB ACACA NNMT FOLR2 MTRR GSTO1 MTR ABCD4 SLC2A1 LMBRD1 LRP10 LRP12 TTPA AKR1C1 HSP90AA1 AKR1C4 TCN2 PC PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT TTR ABCC1 PARP6 PARP4 PRSS3 PARP16 PARP9 PARP14 PARP8 PARP10 SLC2A3 PRKG2 AKR1C3 RDH11 AKT1 LRAT PCCA MMAA PCCB MMUT RBP4 RBP2 SLC23A2 MMAB RBP1 CYB5A MMACHC MMADHC RETSAT CYB5R3 SLC23A1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants FLT3 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function LRAT RBP1 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis PPA1 LHPP PPA2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism MCCC2 ACACA MCCC1 BTD HLCS MTRR PC MTR CBLIF ABCD4 PCCA CUBN MMAA AMN PCCB CD320 MMUT LMBRD1 TCN2 MMAB MMACHC MMADHC INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria CASP4 CALM1 GBP1 GBP6 UBA52 UBE2D2 HBA2 CALM3 UPK1A EPCAM CALM2 GBP2 HBB UBB GBP4 UBC RPS27A LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions STX1B CACNG8 CACNG2 CACNG3 CACNG4 STX1A DLG4 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle RHOT1 RHOT2 RAP1GDS1 TRAK1 MFN1 MFN2 MYO19 TRAK2 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling CASP8 TNFRSF10B TNFRSF10A TNFSF10 TNFRSF10D CASP10 FADD CFLAR BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression PPARA SERPINE1 NAMPT SMARCD3 F7 CHD9 NPAS2 HELZ2 TGS1 BHLHE41 NOCT KLF15 TBL1X BHLHE40 BMAL2 NCOA1 MED1 AVP NCOA2 CREBBP NCOA6 TBL1XR1 CARM1 BMAL1 CLOCK RXRA CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation IGLV3-25 IGLV3-27 PTPN6 IGKC IGLV3-21 CD79B IGKV1-39 CD79A IGKV1-33 IGHV3-53 IGHM IGLC7 IGKV5-2 IGKV1-5 IGLC6 IGHD IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CD22 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 LYN IGKV3D-20 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors YWHAG YWHAZ FOXO6 AKT2 FOXO4 FOXO1 YWHAQ AKT3 SFN AKT1 FOXO3 YWHAB PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors GATA4 NPR1 NKX2-5 NPR2 NPPC CORIN HIPK1 KAT2B WWTR1 MME HIPK2 CES1 NPPA TBX5 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function JUP CTNNB1 SOX10 CDH19 ZC3H12A CTNND1 CTNNA1 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot SERPINB2 ANXA2 HRG PLAT SERPINB8 SERPINE1 SERPINB6 PLAU S100A10 SERPINF2 PLAUR PLG SERPINE2 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly CASP5 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 CASP3 PAK2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs CHUK NFKBIA ZBP1 TBK1 IRF3 NLRP4 DTX4 RIPK3 NFKBIB NFKB2 MYD88 RELA TICAM1 DHX9 IKBKB TLR3 NKIRAS1 NKIRAS2 RIPK1 IKBKG NFKB1 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification ATP6V1H RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking TRAPPC2L SBF2 TRAPPC6A TBC1D20 TSC2 TRAPPC6B TSC1 RAB1A ALS2 RAB1B RAB8A TRAPPC2 TRAPPC3 TRAPPC1 TRAPPC10 TRAPPC4 DENND1C TRAPPC5 DENND1B TRAPPC9 GDI1 DENND5B DENND1A GDI2 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C SBF1 DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 DENND6A RIN1 RIN2 DENND3 RAB21 ALS2CL CHML ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB39B TRAPPC8 RAB12 RAB18 RAB3GAP2 RAB3GAP1 MON1A MON1B RAB11A GAPVD1 RAB3A RAB10 RAB14 RAB13 ARF6 RAB7A YWHAE MAP1LC3B OPTN RAB6A RAB6B RIC1 RGP1 RAB9A RAB9B RABGAP1 GABARAP GGA2 RABGEF1 RAB27B GGA1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B TBC1D2 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B CHM RAB27A RAB5B RAB5C RAB5A AKT2 AKT3 AKT1 RAB3IP DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I VWF CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding GNGT1 STAT3 GBA1 GNGT2 ACTB DCAF7 CCT6B CCNE2 TUBB6 TUBB3 TUBB1 CCNE1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B TUBA4A FBXW2 XRN2 GAPDHS FKBP9 TP53 CCT6A GNAQ HDAC3 GNG10 GNG3 PDCL FBXL3 GNG2 FBXL5 TUBA8 GNG5 WRAP53 TUBA1C GNG4 TUBA1B GNG7 TUBA1A GNG8 KIF13A CCT3 CCT2 CSNK2A1 VBP1 SPHK1 CSNK2A2 TUBB2B TUBB2A CSNK2B SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 GNA15 TUBA3D TUBA3C GNA11 CCT8 CCT7 GNG12 CCT5 GNG11 CCT4 GNG13 NOP56 ARFGEF2 GNB2 TUBB4B TUBB4A GNB1 RGS11 GNB4 GNB3 GNB5 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B CYP2R1 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions BSG ATP1B3 ATP1B2 ATP1B1 MAG SLC3A2 SLC16A1 SLC7A11 L1CAM SLC7A10 ITGB1 ITGA3 SLC7A5 SPN MMP1 SLC7A6 PPIL2 SLC7A7 SLC7A8 SLC7A9 ITGA6 SLC16A8 SLC16A3 CAV1 PPIA FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) HIRA UBN1 RB1 HMGA2 H1-1 H1-0 H1-3 TP53 H1-2 HMGA1 H1-5 H1-4 LMNB1 CABIN1 ASF1A EP400 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling FGF9 FGF20 FGF23 FGF16 SOS1 FGF18 NRAS FRS3 HRAS FRS2 FGF1 FGF2 PTPN11 FGF4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PPIE LIG1 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 XRCC1 LIG3 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 POLK POLE AQR ERCC8 RFC5 RFC3 RFC4 RFC1 RFC2 PRPF19 ISY1 PCNA POLD3 POLD4 POLD1 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases NTRK3 PPFIA3 PPFIA2 IL1RAPL2 IL1RAPL1 PPFIBP1 PPFIBP2 PTPRS SLITRK2 PTPRF SLITRK1 SLITRK4 SLITRK6 SLITRK3 LRRC4B PTPRD SLITRK5 PPFIA1 PPFIA4 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT PLK1 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG DAGLA ABHD6 ABHD12 DAGLB MGLL COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding TUBA4B TUBA4A CCT6A TUBA8 TUBA1C TUBA1B TUBA1A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 TUBA3E TUBA3D TUBA3C CCT8 ACTB CCT7 CCT5 CCT6B CCT4 TUBB6 TUBB3 TUBB1 TUBB4B TUBB4A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere POLR2I H2AC6 POLR2J H2AC7 POLR2K ACD H2AX POLR2L H3-3B H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 DAXX ATRX H2BC1 H4C9 TINF2 POLR2A POLR2B POLR2C H2AB1 POLR2D H2AZ2 POLR2E H2AC20 POLR2F POLR2G POLR2H H2AC8 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression H2AC6 H2AC7 H2AX SUV39H1 H3-3B TBP H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAF1D H2BC9 TAF1B H2BC8 TAF1C H2BC5 H2BC11 TAF1A H2BC3 SIRT1 RRP8 H2BC1 H4C9 H2AB1 H2AZ2 H2AC20 H2AC8 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 PNMT DDC TH DBH TPH2 ASMT AANAT CAV1 DIO1 DIO2 TPH1 TXNDC11 DIO3 SLC5A5 DUOX1 TPO SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5A STAT5B SOS1 KIT PIK3R3 PIK3R2 PIK3R1 PIK3CA LCK JAK2 STAT1 NRAS LYN STAT3 HRAS YES1 FYN UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CALM1 GRIA3 GRIA4 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 NEFL GRIA2 CAMK2G SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane INPP5E PIK3C2G PIK3C3 FIG4 PIKFYVE TPTE2 PI4KB PIK3C2A PI4K2B PI4K2A VAC14 SACM1L OCRL PI4KA ARF1 PIK3R4 TPTE ARF3 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F2 F12 KLKB1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) TAS2R9 TAS2R19 TAS2R40 TAS2R8 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM3 GRM2 GRM4 GRM7 GRM6 GRM8 TAS2R1 TAS2R30 TAS2R3 TAS2R31 TAS2R5 CASR TAS2R4 TAS2R38 TAS2R39 TAS2R60 TAS1R2 TAS2R50 TAS1R1 GRM1 GRM5 TAS1R3 GPRC6A GABBR2 GABBR1 TAS2R20 TAS2R10 TAS2R13 TAS2R14 TAS2R7 TAS2R16 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection FURIN CD3G IL6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 ADAM17 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 PRKACG IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK GNGT1 GNGT2 GNAT3 AHCYL1 ADCY9 PRKAR1B PRKAR2B PLCG2 PRKACA SYK GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 IGHG3 GNG7 IGHG4 PRKAR1A GNG8 IGHG1 CYSLTR1 IGHG2 IL10 CYSLTR2 CD163 GGT1 PLK2 DPEP2 RHBDF2 DPEP1 MYH9 GNAZ GGT5 FCGR3A LYN FGR YES1 GNG12 ADORA2B GNG11 FCGR1A GNG13 GNB2 GNB1 FCGR2A GNAS GNB4 GNB3 GNB5 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression AP2M1 CD28 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling PTPN6 RAPGEF1 SOS1 PRKACA CRK BLNK SYK IL2RG INPPL1 JAK3 INPP5D JAK1 VAV1 PIK3CD PIK3CB CBL STAT5A STAT5B YWHAZ HCK GAB2 TEC PIK3R3 PIK3R2 PIK3R1 PIK3CA SHC1 JAK2 CRKL IL2 IL3 LYN YES1 IL5RA CSF2RB CSF2RA FYN IL5 IL2RB IL3RA PTPN11 CSF2 IL2RA INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption RSC1A1 SLC2A2 SLC5A1 SLC2A5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization VAV1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 GRAP2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 TXK IGKV3D-20 V5-6 IGHE PPP3CA IGLV3-19 PPP3CB IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 PPP3R1 IGHV3-48 NFATC3 IGLV3-25 NFATC2 IGLV3-27 NFATC1 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 TEC AHCYL1 BTK PLCG2 VAV3 SYK VAV2 ITPR1 ITPR2 ITPR3 LYN ITK LCP2 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) SLC6A19 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD2 ENTPD5 ENTPD3 ENTPD4 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping MAPK8 CYBA DVL1 DVL2 NOXO1 NOXA1 DVL3 WNT5A JUN FZD7 NOX1 RAC1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling CBFB RUNX1 ESR1 RSPO3 FOXP3 AXIN1 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 SETD9 ATM EP300 JMY UBA52 CHEK2 TP53 EHMT2 EHMT1 MDM2 TTC5 MDM4 PRMT5 SMYD2 UBB UBC KMT5A RPS27A BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion CD4 CCR5 CXCR4 PPIA ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO BOC KIF3A GAS1 PTCH1 ARRB1 CDON IHH DHH ARRB2 GRK2 SHH CSNK1A1 EVC2 IQCE EFCAB7 EVC DRC4 SMO TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production PRKAR2B PRKACA PRKACG GNAI3 ADCY4 PRKACB ADCY3 PRKX IL6 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 PRKAR1A GNAZ GNGT1 GNGT2 GNG12 ADORA2B GNG11 GNG13 GNB2 GNB1 GNAT3 GNAS GNB4 GNB3 GNB5 ADCY9 PRKAR1B CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 JAG2 JAG1 ADAM10 DLL1 DLL4 ADAM17 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling JAK1 STAT5A STAT5B PTK2B SYK IL2RB IL2RG JAK3 SHC1 LCK IL2RA IL2 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis CASP8 RIPK3 MLKL RIPK1 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle CDC42EP1 GIT2 DOCK2 ARHGAP26 DOCK1 TAOK3 RAB7A ABI2 EPHA2 VAMP3 ABI1 GARRE1 ARHGAP39 ARHGAP21 LMAN1 PAK4 TFRC MCF2 MCAM ERBIN VAV1 MPP7 SAMM50 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 VAPB ESYT1 PAK1 MTX1 RAC2 PAK2 DOCK3 DSG2 PLD2 TIAM1 CAV1 CDC42EP4 VAV3 DEF6 VAV2 ARMCX3 LBR PGRMC2 NCKAP1 NCF1 NCF2 NCF4 ITGB1 BRK1 CYFIP1 DOCK10 ANKLE2 SYDE1 PIK3R3 DOCK4 ARHGAP42 PIK3R2 IQGAP1 TRIO BAIAP2L1 PIK3CA PIK3R1 ARHGAP1 GIT1 SWAP70 ARHGAP35 CYBB PREX1 OPHN1 ARHGDIA CYBA STBD1 BCR CDC42 EMD ARHGAP17 TMPO ABR RACGAP1 VRK2 NHS LEMD3 SLITRK5 NCKAP1L DEPDC1B WASF2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL PIP5K1B CSNK2B CSNK1E DVL1 DVL2 DVL3 CSNK2A1 CSNK2A2 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A AKT2 FOXO1 AKT3 AKT1 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions VTN H3C8 CTNNB1 H3C15 RICTOR H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 SNW1 ELAVL1 C4BPA C4BPB CLU NEK2 H2AC8 H2AC6 EXOC1 H2AC7 SNRPD2 SNRPD1 SNRPD3 GBF1 SNRPG SNRPE LY96 PRR5 SNRPF SNRPB H2BC26 H2BC21 MLST8 H2BC17 C4A H2BC12 C4B_2 H2BC13 H2BC14 H2BC15 APOA1 H2BC11 TLR4 MTOR H2BC18 COG1 BECN1 NCBP1 NCBP2 FIP1L1 IFIH1 TRIM25 GRPEL1 MAVS PQBP1 HSPG2 SDC4 TAL1 SDC2 SRRT SDC3 SNRNP200 FUS HSP90AB1 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA0 HNRNPA3 SDC1 GPKOW CDC5L CCAR1 CD2BP2 PCBP1 CPSF7 PCBP2 RBM10 DDX5 RETREG1 SUGP1 DHX15 VIM HNRNPC DHX16 RBMX PEX19 HNRNPA2B1 WBP11 HNRNPUL1 PPIE DDX3X DDX46 RPTOR DDX42 RBM17 DYNLT1 GPC1 BUD31 MMP9 GPC3 RBM22 DDX23 GPC2 SMNDC1 GPC5 U2SURP HNRNPR GPC4 STAT2 NRBP1 GPC6 CPSF1 CSTF3 ATG14 CPSF3 CSTF2 CPSF2 AGRN CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 XAB2 PHF5A DAXX AUP1 CLEC5A TXNL4A SNRPN CHERP HSPA8 PTBP1 PLRG1 SNRPA1 DNAJC8 PUF60 SNRPB2 PPIL1 SNRNP40 PPIL3 PPIL4 PPIL6 SRRM2 AQR CPSF4 CRNKL1 PIK3R4 PRPF19 HNRNPH1 HNRNPH2 CWC25 PDCD6IP PIK3C3 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 HSP90AA1 CWC15 ELAVL2 RBM5 RIPK1 PABPN1 RPL18 CDC73 TAOK1 SKIC8 CTR9 RTF1 IKBKE LEO1 PAF1 NFKBIA FASN HNRNPU NFKBIB TJP1 EIF4A3 UBE2I F2 CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SRSF9 GTF2F1 GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 H2AC17 H2AC12 U2AF2 DHX38 CAMK2B SRSF11 CAMK2D H2AC1 CAMK2A ALYREF H2AC19 H2AC25 H2AC14 H2AC21 RNPS1 CAMK2G UBR4 MBL2 MAPKAP1 C1QA C1S CGAS H4C9 DHX9 H2AC20 STING1 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription WWTR1 TEAD3 CCN2 TEAD4 YAP1 TEAD1 RUNX3 TEAD2 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling DOCK1 WASL PTK2 TRIO RAC1 NCK1 DCC ABLIM1 ABLIM2 NTN1 ABLIM3 CDC42 SRC DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors LTB4R PTGER4 PTGER2 PTGER3 TBXA2R PTGFR PTGIR LTB4R2 PTGDR2 OXER1 PTGER1 PTGDR GPR17 CYSLTR1 CYSLTR2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) GSDMD MEFV CTSG NFKB2 RELA NT5E PYCARD HSP90AB1 NFKB1 HMOX1 C3 CASP1 NLRP3 IL18 PSTPIP1 IL1A IL1B P2RX7 P2RX4 TXNIP TXN C3AR1 SUGT1 ENTPD1 ENTPD5 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction MYBPC3 TMOD1 MYBPC1 MYBPC2 ACTN3 TMOD4 TNNC1 TMOD2 TNNC2 NEB DMD MYL4 MYH3 DES MYL1 TNNT1 MYL2 TNNT2 ACTN2 MYL3 TNNT3 MYH8 TCAP MYH6 TTN TNNI3 TMOD3 TPM4 TPM3 TPM2 VIM TPM1 TNNI1 TNNI2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) MPG LIG1 POLE PARG RFC5 RFC3 ADPRS RFC4 RFC1 RFC2 FEN1 OGG1 NTHL1 TDG MBD4 SMUG1 PCNA NEIL2 POLD3 NEIL1 PNKP POLD4 POLD1 POLD2 PARP1 PARP2 POLB APEX1 XRCC1 LIG3 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins POM121C SUMO2 NUP42 AURKA NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 CDCA8 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 TOP2A PCNA TOP2B NUP133 PIAS4 PIAS3 RANGAP1 TOP1 UBE2I INCENP BIRC5 NUP205 POM121 NUP107 NUP188 AURKB SUMO1 AAAS SUMO3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 DNM2 DPYSL2 AP2A1 AP2A2 SHTN1 AP2M1 EZR RPS6KA1 RDX MSN L1CAM KIF4B KIF4A RPS6KA5 AP2S1 SH3GL2 CLTC DNM1 CLTA DNM3 NUMB RPS6KA3 AP2B1 RPS6KA2 MAPK1 RPS6KA6 RPS6KA4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA AFF4 ELOB CDC73 NELFB MLLT1 ELOC MLLT3 NELFCD SUPT6H NELFA IWS1 NELFE EAF1 SUPT16H EAF2 TBP NCBP1 SKIC8 NCBP2 GTF2A1 GTF2A2 CTR9 CTDP1 RTF1 TAF9 SUPT4H1 TAF1L LEO1 GTF2E1 GTF2E2 TAF15 TAF12 TAF13 PAF1 TAF10 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora NHLRC1 GYG1 EPM2A UBB UBA52 UBC GYS1 RPS27A PPP1R3C NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 XPO1 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription NOTCH1 NOTCH2 EP300 RBPJ MAML2 CREBBP MAML1 NOTCH4 HEY1 FLT4 KAT2B HEY2 KAT2A ACTA2 MAMLD1 SNW1 SMAD3 HES1 HES5 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 STAT3 PTK6 SOCS3 STAP2 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants FZD8 LRP5 FZD5 FZD4 LRP6 WNT3A FZD6 RNF43 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies SI LCT CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 H2BC17 H2BC12 H2BC13 NEIL3 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils BMP1 PCOLCE TLL2 TLL1 LOX LOXL3 LOXL4 LOXL1 PXDN LOXL2 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins DNAJB11 NMT1 DPM1 DPM2 DPM3 KPNA1 MAGT1 UBA52 UBB UBC RPS27A HSPA5 ACOT2 UBE2I IPO7 P4HB KPNA7 TUSC3 KPNA4 P4HA1 P4HA2 KPNA5 P4HA3 SUMO1 KPNA2 KPNA3 SCAP TMEM258 SEC11A SEC11C HYOU1 PRKG2 OST4 OSTC STT3A KPNB1 STT3B XPO1 RPN2 CALR DDOST SPCS3 RPN1 SPCS2 SPCS1 DAD1 PDIA3 APOA1 DNAJC10 DNAJC3 CANX DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling CHUK CD4 HLA-DRB3 HLA-DRB1 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 CD3G PSMA1 PSMA2 CD3E UBA52 CD3D CARD11 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 INPP5D RIPK2 BCL10 PSMA7 RELA HLA-DPA1 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 HLA-DQB2 UBC HLA-DQB1 PSMB1 RPS27A ADRM1 TRAT1 NFKB1 SEM1 TRBV12-3 NFKBIA PSMC5 PSMC6 TRBV7-9 PSMC3 PSMC4 PSMC1 PSMC2 UBE2D2 TRAV8-4 HLA-DPB1 TRAC CDC34 PRKCQ UBE2V1 TRAV19 HLA-DRA PTEN TRBC1 PIK3CB UBE2N PDPK1 TAB2 PIK3R2 PIK3CA PIK3R1 LCK TRAV29DV5 HLA-DQA2 HLA-DRB5 PSMD8 HLA-DRB4 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters CD4 CD8B AP2A1 AP2S1 AP2A2 LCK AP1G1 PACS1 AP2M1 AP1S2 AP1B1 AP2B1 AP1S1 AP1S3 HLA-A ATP6V1H ARF1 B2M AP1M2 AP1M1 CD28 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription CBX6 PHC2 EZH2 PHC1 SALL4 MTA2 CBX4 CBX2 REST RCOR1 RPTOR JUN PHC3 RRAGA RRAGC BMI1 RRAGB RRAGD RING1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 RNF2 LAMTOR3 LAMTOR5 ATN1 MAF1 MTA1 HDAC1 SUZ12 MTA3 MAPK1 MAPK3 SNAI2 PPARG TP53 NR2E1 ATF2 HDAC3 MECOM MBD3 MLST8 EED GATAD2B GATAD2A EGR1 HDAC5 KDM1A HDAC2 HDAC7 SNAI1 CHD4 RBBP4 CHD3 RBBP7 MTOR CBX8 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic GOSR1 TMED2 ARF4 ACTR1A SEC22B RAB1A TMED10 COPZ2 COPZ1 GOSR2 GALNT2 RAB1B KIF4B KIF4A MAN1A2 MAN1C1 MAN1A1 RAB41 KIF20A RAB30 KDELR3 KLC1 RAB36 KLC4 KLC3 DCTN1 KLC2 KIF11 KIF15 AGPAT3 ARF1 BET1L KIF23 KIF22 NSF KIF26A M6PR DCTN2 DCTN3 DYNC1LI1 RAB39A DYNC1LI2 ZW10 RAB18 RAB3GAP2 VPS45 RAB3GAP1 GBF1 TMED3 TMED7 TMED9 TRIP11 KIF18A COPG2 COPG1 COPB2 COPA COPB1 DYNLL1 MAN2A2 COPE DYNLL2 ARFGAP1 KIF2A USP6NL SCOC KIF2C CUX1 SYS1 KIF2B GCC2 GCC1 RACGAP1 RABEPK PAFAH1B1 RAB43 DYNC1I2 GOLGA4 GOLGA1 ARFIP2 ARFGAP3 NAA30 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 DYNC1I1 NAA35 VAMP3 NAA38 VAMP4 NAPA DYNC1H1 NAPB TMF1 STX16 CENPE RHOBTB3 ARL1 DCTN6 DCTN5 NAPG STX5 DCTN4 STX10 YKT6 TGOLN2 BICD1 BICD2 ARFRP1 VPS51 CAPZA3 VPS53 ACTR10 PAFAH1B3 VPS52 VTI1A PAFAH1B2 STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B GOLIM4 CAPZB RAB33B CYTH3 CYTH2 GOLGA5 PLIN3 CYTH4 SNAP29 CYTH1 ALPP MAN2A1 CAPZA1 CAPZA2 PLA2G6 GALNT1 ARF5 KIF5C PLA2G4A ARCN1 KIF5B KIF5A KIFAP3 KIF28P KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KDELR2 KIF25 KIF6 KIF27 RINT1 ARFGAP2 KIF9 KIFC2 KIF16B KIFC1 KIF20B KIF3B KDELR1 KIF3A NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF3C ARF3 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME CYP2C19 BSG CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP2E1 CES1 UGT1A3 SLC16A1 BCHE CES2 GLYATL3 GLYATL2 GLYATL1 ACSM2A UGT2B10 ACSM5 UGT2B11 ACSM4 UGT2B15 GLYAT UGT2B17 UGT3A2 UGT3A1 UGT2A3 UGT2A2 UGT2A1 UGT1A1 ACSM2B ABCC2 UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 ABCC3 ALB UGT1A6 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events EP300 LIN54 PLK1 LIN52 LIN37 PKMYT1 LIN9 CDC25C CDC25A WEE1 CENPF CCNB1 CCNB2 RBBP4 MYBL2 FOXM1 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants FLT3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA TRIM32 ZBP1 TBK1 IRF3 NLRP4 DTX4 TRIM21 UBA52 DDX41 TRIM56 UBB UBC TREX1 RPS27A STING1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX CYP27A1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 NUP85 EIF4E NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS1L1 PRPS2 PRPS1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells NEUROD1 IAPP NKX6-1 NKX2-2 PDX1 INS PAX6 HNF1A MAFA FOXO1 RFX6 FOXA3 GCK FOXA2 SLC2A2 AKT2 HNF4G AKT3 AKT1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PPP2R1B PPP2R1A PRKACA PRKACG PFKFB2 PFKFB1 PPP2R5D PRKACB PFKFB4 PFKFB3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 SGCE LAMA4 SNTG2 LAMA3 FN1 SGCD LAMC2 SGCA SGCB LAMB1 DMD LAMC1 VTN SGCG SNTA1 DTNA KLKB1 DTNB SGCZ SSPN SNTB1 SNTB2 PRSS1 CTRB2 CDH1 CTRB1 TRAPPC4 PDGFA BMP10 CTSV CTSL CTSK ADAM10 ADAM17 PTPRS F11R ICAM1 CEACAM1 COL17A1 COL18A1 PXDN COL15A1 COL16A1 COL13A1 ICAM2 COL14A1 ICAM3 COL11A1 COL11A2 BMP4 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 ITGB1 COL24A1 COL25A1 COL22A1 COL23A1 COL3A1 COL2A1 COL4A2 COL5A1 NRXN1 COL4A1 COL7A1 BMP2 COL6A2 COL5A3 COL4A4 COL5A2 COL6A1 COL4A3 COL4A6 VCAM1 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CAST SERPINE1 SPARC CAPNS1 CAPNS2 LOX LOXL3 CAPN2 LOXL4 CAPN1 LOXL1 KLK2 LOXL2 PSEN1 CAPN15 PHYKPL NCSTN OPTC KLK7 PDGFB GDF5 DDR1 ELN KDR MMP20 MMP25 MMP24 TPSAB1 A2M MMP10 MMP12 MMP11 CEACAM6 MMP15 MMP17 MMP19 CEACAM8 DDR2 TMPRSS6 MMP1 EFEMP2 CAPN8 EFEMP1 CAPN9 CAPN6 P4HB CAPN7 CAPN5 CAPN3 ADAM9 ITGAM ADAM8 ITGB2 TNC FBN2 ICAM4 FBN3 ICAM5 CD151 HTRA1 ITGAE COMP FBLN1 IBSP FBLN2 FBLN5 ITGAX SCUBE3 ITGB7 SCUBE1 ITGAD CD47 MMP8 JAM2 SPOCK3 JAM3 MFAP5 ITGA11 ITGAV CAPN13 CTSG FBN1 MFAP4 CAPN14 CAPN11 DAG1 CAPN12 CAPN10 MFAP3 HSPG2 MFAP2 SDC4 SDC2 SDC3 MMP7 PECAM1 COLGALT2 PLOD3 PLG PLOD2 PLOD1 COLGALT1 P3H2 P3H1 PCOLCE P3H3 PCOLCE2 SERPINH1 SDC1 CRTAP ACTN1 SH3PXD2A ADAM19 CTSD MMP2 ITGA2B FURIN CD44 PPIB MMP9 NCAN BGN COL1A1 DCN COL1A2 PLEC BCAN FMOD VCAN AGRN ITGA10 ITGB5 ITGA9 NCAM1 P4HA1 P4HA2 P4HA3 CASK BSG MMP13 ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTS1 SPP1 ADAMTS8 ADAMTS9 TGFB1 FGF2 ADAMTS16 ADAMTS14 ITGB4 ADAMTS18 ITGA3 ITGA2 ITGA1 NID1 NID2 ITGA7 ITGA6 ACAN LUM ELANE HAPLN1 TNN TNR MUSK ASPN MATN1 MATN4 TNXB LRP4 DSPP ADAM15 ADAM12 UTRN CMA1 NTN4 BMP7 CASP3 TTR DRP2 TIMP2 TIMP1 TGFB2 DMP1 PRSS2 MMP14 MMP16 PRKCA LTBP4 LTBP2 LTBP3 ITGAL LTBP1 ITGB8 THBS1 CTSS ITGB6 CTSB TGFB3 ITGA8 ITGA4 ITGB3 MMP3 ITGA5 MATN3 FGB FGA BMP1 TLL2 FGG TLL1 LAMA5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events AKT2 PDE3B DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis GYG2 GYG1 EPM2A GBE1 UBA52 GYS2 GYS1 PPP1R3C NHLRC1 UGP2 UBB UBC PGM1 RPS27A SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste SCNN1A CALHM1 SCNN1G SCNN1D SCNN1B CALHM3 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions COL9A2 COL6A5 CACNA1S PRNP PSPN NCAN ST8SIA4 CACNA1C ST8SIA2 GFRA1 AGRN CNTN2 GDNF CACNA1H CACNB1 CACNB2 CACNB3 CACNB4 CACNA1G CACNA1I COL4A2 COL4A1 COL6A2 COL4A4 NCAM1 ARTN COL6A1 COL4A3 COL9A1 GFRA2 CACNA1D GFRA4 COL6A3 COL4A5 COL9A3 NRTN COL6A6 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall FN1 SHC1 IGHV3-23 NRAS IGLV IGLV2-8 IGKV1-16 IGKV1-17 HRAS IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 CD74 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 F11R V2-8 V1-20 CEACAM1 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 APOB IGKV3-20 ITGB1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 LCK IGLC3 IGLC1 IGLC2 SPN V1-9 V5-4 PPIL2 V1-7 V5-1 V1-5 SLC16A8 V1-3 IGKV3D-20 V5-6 SLC16A3 FYN IGLV3-19 IGKV2-30 PPIA IGHV2-70 IGHV2-5 PTPN11 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 PTPN6 IGKC IGLV3-21 FCER1G IGKV1-39 GP6 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 SLC3A2 SLC7A11 SLC7A10 CEACAM6 CEACAM8 SLC7A5 SLC7A6 MMP1 SLC7A7 EPCAM SLC7A8 SLC7A9 CAV1 PROC ITGAM ITGB2 ITGAX CD47 JAM2 JAM3 ITGAV VPREB3 SELP VPREB1 CXADR PSG1 SDC4 PSG3 SDC2 PSG2 SDC3 PSG9 FCAMR PSG8 PECAM1 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 OLR1 CEACAM3 CD48 SDC1 SELPLG CD58 IGLL1 CD84 SIRPG SIRPA JAML PSG11 CD99 GRB7 SELE SELL ESAM TREM1 CD2 CD244 PF4 CD44 IGHM GPC1 INPP5D MAG L1CAM BSG TSPAN7 CEACAM5 SLC16A1 TGFB1 PICK1 ITGA3 ITGA6 TNFRSF10B TNFRSF10A PROS1 MERTK GAS6 F2 ANGPT1 TEK THBD PF4V1 CD177 PROCR DOK2 ATP1B3 TNFRSF10D ATP1B2 ATP1B1 IGHA1 IGHA2 ANGPT4 JCHAIN ANGPT2 GRB14 ITGAL ITGA4 ITGB3 ITGA5 PIK3R2 MIF PIK3R1 LYN YES1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation ACD PRIM2 PRIM1 POLA1 POLA2 CTC1 TINF2 STN1 TERF1 TEN1 TERF2 POT1 TERF2IP GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants FLT3 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE CEPT1 CHKB CHKA SELENOI PHOSPHO1 ETNPPL ETNK2 ETNK1 PCYT2 PISD LPIN1 LPIN2 LPIN3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors GRIP2 GRIA1 PRKCB AP2A1 TSPAN7 GRIA3 GRIA4 PRKCA GRIP1 NSF PRKCG GRIA2 PICK1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand ACD DNA2 PCNA POLD3 POLD4 WRN POLD1 POLD2 TINF2 RPA1 RPA2 TERF1 TERF2 RPA3 POT1 TERF2IP FEN1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 MDM2 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 VHL PIAS4 UBE2I PIAS1 NUP205 POM121 NUP107 NUP188 TRIM27 SUMO1 AAAS PML PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 PIK3R1 PIK3CA FGFR4 GAB1 KLB FRS2 FGF1 FGF2 PTPN11 FGF4 FGF6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism MANBA MAN2B2 MAN2B1 MAN2C1 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC67A1 SLC22A5 SLC22A2 SLC22A1 SLC47A2 SLC22A4 RSC1A1 SLC14A1 RUNX1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC22A3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism UST CHST3 IDUA HEXB NCAN HEXA BGN DSE DCN GLB1L3 GLB1L2 CHST11 CHST12 BCAN CHST15 VCAN CHST13 GLB1L CHPF GLB1 HYAL1 CHST14 CHPF2 HYAL3 HYAL4 CSPG5 IDS CSGALNACT1 CSPG4 GUSB ARSB CSGALNACT2 CHST7 CHSY1 CHSY3 DSEL THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model SLC25A27 UCP3 UCP2 SLC25A14 UCP1 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation SNAI1 EOMES FGFR1 TBXT AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation ARHGDIA RHOA NGF NGFR CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication LAMB3 EZH2 H2AX CDH4 LAMA3 LAMC2 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B CLDN2 H3C8 MTBP ZC3H12A CSNK2A3 CLDN6 H2AJ CLDN4 CLDN3 SRC CLDN9 CTNND1 CLDN8 CLDN7 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 CLDN22 CLDN20 ZMYM2 CLDN23 RACK1 CLDN11 CLDN10 CLDN15 CLDN14 SUZ12 CLDN12 H2BC9 CLDN19 H2BC8 CLDN18 H2BC5 CLDN17 CLDN16 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST SDK1 H2AC8 SDK2 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 PARD6G PARD6B MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 PXN PATJ F11R COL17A1 PALS1 ZEB1 CRB3 PARD6A PARD3 PIK3CB H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 ITGB1 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 FYN RBBP7 H2AZ2 PTPN11 TGIF2 TNRC6C PTPN6 DOCK1 TNRC6A ACTN3 TNRC6B ARHGEF4 FERMT2 ARHGEF6 ACTN4 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PTK2B PRKCSH SNAI2 GANAB CD151 CD47 WASL MOGS PTK2 TCF12 VAV2 FLNA ACTN2 VASP SIRPG PRDM8 SIRPA BHLHE22 KDM1A CDH8 ACTN1 CTNNA1 NCK2 CDH24 NCK1 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 CLDN5 SNAI1 DST TESK1 CD2AP SKAP2 ZNF217 RSU1 PARVA PARVB FLNC LIMS2 FURIN PCSK6 LIMS1 KIRREL3 KIRREL1 KIRREL2 MAGI2 FBLIM1 ANK3 ILK SIRPB1 NPHS1 TYK2 SPTBN1 PLEC RB1 SPTAN1 POMT2 CASK DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 ITGB4 ITGA6 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PRKCI PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CLDN1 TYROBP RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 PIK3R2 IQGAP1 PIK3R1 JAK2 H4C9 FYB1 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres PPP6C ACD PPP6R3 LIG1 PRIM2 PRIM1 POLA1 POLA2 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP FEN1 ANKRD28 GAR1 CDK2 DSCC1 RUVBL2 SHQ1 PIF1 CHTF8 RFC5 CTC1 CHTF18 RFC3 TERT STN1 WRAP53 RFC4 TEN1 RFC1 RFC2 DNA2 DKC1 NHP2 BLM RTEL1 PCNA POLD3 POLD4 WRN RUVBL1 POLD1 NOP10 POLD2 TINF2 RPA1 RPA2 RPA3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification SERPINA1 PPP6C GOSR1 TFG PPP6R1 PPP6R3 TMED2 ARF4 CTSC TRAPPC2L LMAN1L ANK2 ANK3 F5 ANK1 F8 TRAPPC6A TBC1D20 ACTR1A TRAPPC6B GORASP1 PREB CHST10 GOLGB1 SEC22B SPTBN4 SEC22A SPTBN5 SEC22C SPTA1 RAB1A TMED10 LMAN2L ST8SIA6 SPTBN1 COPZ2 STX17 SPTBN2 COPZ1 GOSR2 RAB1B USO1 SCFD1 ST8SIA2 LMAN2 CD59 SEC31B ST8SIA3 SEC31A MAN1A2 ANKRD28 MAN1C1 TRAPPC2 MAN1A1 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SPTAN1 SEC23IP CNIH1 SPTB KDELR3 CNIH2 CNIH3 DCTN1 FOLR1 BET1 ARF1 CTSZ FUT3 BET1L AREG SEC23A NSF SAR1B MANEA GRIA1 DCTN2 LHB DCTN3 SEC24B DYNC1LI1 SEC24A DYNC1LI2 B4GALT2 B4GALT3 B4GALT1 GBF1 TMED3 SEC24D TMED7 SEC24C TMED9 B4GALT6 SEC13 COPG2 COPG1 COPB2 COPA B4GALT4 B4GALT5 COPB1 DYNLL1 MAN2A2 TMEM115 COL7A1 COPE DYNLL2 ARFGAP1 DYNC1I2 ARFGAP3 COG8 COG7 COG6 COG5 COG4 INS COG3 COG2 COG1 DYNC1I1 NAPA DYNC1H1 NAPB DCTN6 LMAN1 GOLGA2 DCTN5 NAPG STX5 DCTN4 YKT6 CAPZA3 ACTR10 FUCA1 CAPZB FUT8 MAN2A1 MGAT5 CAPZA1 ST3GAL4 MGAT3 CAPZA2 MGAT1 CHST8 MGAT2 CGA ST6GAL1 MGAT4C ARF5 MGAT4A MGAT4B ARCN1 CSNK1D CD55 KDELR2 MIA3 ARFGAP2 KDELR1 MIA2 ARF3 MCFD2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation CTNNB1 MET CDKN1A CDKN2A TCF7 PLK1 HDAC1 CCND1 CDC25B CCNB1 HINT1 LEF1 CDK2 TCF7L2 SIN3A TCF7L1 TBX2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD3G CD3E CD3D HLA-A B2M CDH1 TRBV12-3 TRBV7-9 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 TRAV8-4 IGHV3-9 PVR V2-11 IGHV3-30 V3-4 CD81 V3-3 V2-17 TRAC V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CD19 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 NECTIN2 TRAV19 IFITM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 ICAM1 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ICAM2 IGLV7-43 ICAM3 IGKV1D-12 IGLV1-51 IGLV2-23 C3 CD22 IGKV3-20 ITGB1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 VCAM1 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD8B ITGB2 ICAM4 ICAM5 ITGB7 CXADR JAML CD99 SELL FCGR3A TREM1 FCGR1A CD226 CD1D CD1C CD1B cd21 CD1A KLRK1 SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 KIR2DS2 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 SIGLEC9 NCR1 NCR2 CD200R1 NCR3 HCST LILRA6 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA LAIR1 MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 LILRB2 KIR3DL2 LILRB3 LILRB4 LILRB5 CD40LG SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 SIGLEC5 CD96 OSCAR CD8A KLRF1 CD300E CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG CD160 HLA-H CRTAM COLEC12 HLA-C KLRD1 HLA-F ULBP1 ULBP3 HLA-G PIANP HLA-E KLRG1 CLEC2B FCGR2B CLEC2D HLA-B CD33 TREM2 CD300A TYROBP ITGAL TRBC1 ITGA4 TRAV29DV5 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling EIF4G1 LAMTOR5 FKBP1A RPTOR EEF2K RPS6 RRAGA RRAGC RRAGB RRAGD AKT1S1 EIF4EBP1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 MTOR LAMTOR4 MLST8 LAMTOR3 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes H2AX ASH2L CCNC PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2C GPAM SCD ADIPOQ HDAC3 PHLDA1 ACSL1 PEX11A DPY30 H2BC26 H2BC21 CIDEC WDR5 EP300 TBL1X H2BC17 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 CREBBP NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 PDK4 ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL LIPE DGAT2 MED30 MED31 KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling CDC14A PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 JUN PRKACG UBA52 PSMD12 PRKACB PSMD11 FOXO3 RAC1 PSMD14 KALRN PSMD13 PSMA7 PSMB6 CDK1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FOXO1 PAK3 CCND3 PAK2 SEPTIN7 CDC14B ETV4 IGF2BP1 MAPK6 MAPK4 CDC42EP5 CDC42EP3 RAG2 CDC42EP2 PRKACA RAG1 HSPB1 MYC XPO1 NCOA3 CDC42 PSMD8 PSMD6 MAPKAPK5 PSMD7 PSMD2 MOV10 PSMD3 AGO3 PSMD1 AGO4 AGO1 DNAJB1 AGO2 TNRC6C DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 GPC5 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 IHH SHH P4HB VCP SEL1L ADAM17 DHH HHAT DISP2 SCUBE2 SYVN1 NOTUM ERLEC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 KIF5A CDC42 RHOA KTN1 RHOG KLC1 KLC4 KLC3 RAC1 KLC2 KIF5B CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII SOS1 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF CBL DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown POM121C NUP42 PRKCB NUP62 NUP43 TPR BANF1 NUP88 RAE1 NUP214 RANBP2 NDC1 PLK1 NUP210 NUP155 PRKCA NUP153 CCNB1 NUP93 LMNB1 NUP50 NUP35 NUP54 NUP160 CDK1 CCNB2 NUP85 CTDNEP1 CNEP1R1 NUP37 NEK9 VRK1 NEK6 LEMD2 NEK7 SEC13 NUP133 EMD NUP205 POM121 NUP107 LEMD3 LPIN1 NUP188 LPIN2 AAAS LPIN3 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 NOTCH1 NOTCH2 LFNG NOTCH3 NOTCH4 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones FSHB INHBB INHBC CGA INHBE INHBA TSHB LHB CGB8 INHA PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer TSC2 RAC1 MDM2 AKT1S1 VAV1 SRC TGFA MET CDKN1A RICTOR EREG CDKN1B BTC EPGN HBEGF NTRK2 BDNF GAB1 NTF4 NTF3 CD86 EGF CD80 FRS2 FLT3 AREG CD19 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF PRR5 GSK3B IRS2 PIK3CD FGF1 BAD FGF2 PIK3CB CASP9 FGF3 PIK3CG NRG1 FGF4 FGF6 FGF7 MLST8 FGF9 FGF20 FGF23 FGF22 PDPK1 GAB2 FGF16 FGF19 FGF18 FGFR4 PIK3CA FGF10 LCK FYN RHOG PTPN11 MTOR CHUK FOXO3 PDGFRA PDGFRB TRAT1 PDGFB NTRK3 PIK3AP1 FLT3LG FOXO6 FOXO4 KIT FOXO1 RPS6KB2 RAC2 ESR1 GSK3A ESR2 NR4A1 PTEN AKT2 AKT3 AKT1 ERBB2 STRN MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 CD28 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation COL9A2 MMP13 FURIN MMP8 PRSS2 ADAM10 MMP14 ADAM17 MMP9 MMP7 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 CTSB COL14A1 PHYKPL COL12A1 COL19A1 MMP20 COL26A1 COL25A1 MMP3 MMP10 MMP12 COL23A1 MMP11 MMP15 MMP19 TMPRSS6 MMP1 CTSD COL9A1 ADAM9 CTSL CTSK MMP2 COL9A3 ELANE FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex AXIN2 H2AX PYGO1 PYGO2 ASH2L BCL9L BCL9 MEN1 CDC73 RUNX3 H3-3B H3C8 H2AJ LEO1 CTNNB1 H3C15 KMT2B HDAC1 H2BC9 H3-4 TLE4 H2BC8 TLE2 H2BC5 H2BC3 H2BC1 SMARCA4 H2AB1 TLE1 H2AC8 H2AC6 H2AC7 TCF7 KAT5 H2AC19 H2AC14 H2BC12L TERT MYC DPY30 H2BC26 H2BC21 WDR5 EP300 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP TLE3 H2BC11 RUVBL1 LEF1 H4C9 TRRAP RBBP5 TCF7L2 H2AZ2 TCF7L1 H2AC20 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members FURIN UBE2M TGFBR1 TGFBR2 TRIM33 CCNC UBE2D1 MEN1 MYOG MYOD1 MYF6 TCF4 PPM1A MYF5 COL1A2 ITGB5 CBL CDKN2B NEDD8 MAPK1 SNW1 TFDP1 MAPK3 TFDP2 SKIL ACVRL1 BMP10 BMPR2 AMHR2 FSTL1 CHRDL1 AMH NOG GDF2 PPP1CC SMAD9 MYCN SMAD5 GREM2 ZFYVE16 CDK8 BMPR1B BMPR1A STRAP SP1 ARHGEF18 CGN F11R PRKCZ TGFB1 RHOA PARD6A FGF2 PARD3 XPO1 USP9X EP300 SKI ITGB1 BMP2 PARP1 TCF3 NCOR1 UBE2D3 ACVR1C TGIF1 ACVR1B ACVR2B TGIF2 CER1 TNRC6C FKBP1A TNRC6A TNRC6B CCNK CCNT2 CCNT1 UBA52 STUB1 SERPINE1 FST FOXH1 JUNB DRAP1 RNF111 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B NEDD4L CDK9 PPP1CB HDAC1 ATP1B4 PPP1CA SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 RXRA SMURF1 SMAD6 TIMP2 TIMP1 RARA SMAD7 HELLS TGFB2 INHBA KLF16 ACVR2A ITGAV TGFBR3 MMP14 MMP16 GIPC1 INHA YBX1 TCF12 NCOR2 PPP1R15A USP15 LTBP4 RBL1 LTBP2 LTBP3 MTMR4 MYC LTBP1 ITGB8 PMEPA1 ITGB6 TGFB3 UCHL5 BAMBI ITGA8 INHBB ITGB3 ARRB1 ARRB2 FSTL3 E2F4 WWTR1 E2F5 MOV10 AGO3 AGO4 AGO1 AGO2 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR PTPN3 ARHGEF7 UBA52 UBB SH3GL3 SH3KBP1 SRC UBC RPS27A STAM CBL HGS ADAM12 EPS15 TGFA STAM2 SH3GL2 SH3GL1 EREG BTC EPGN HBEGF SHC1 NRAS GAB1 HRAS PLCG1 EGF AREG PTPN12 ADAM10 SOS1 ADAM17 EGFR PXN AAMP PTPRK LRIG1 FAM83D PAG1 FAM83A SPRY1 SPRY2 PIK3CA PIK3R1 EPS15L1 EPN1 CDC42 FAM83B CSK PTPN11 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB PPP2R1A MKNK1 SPRY2 UBA52 MAPK1 MAPK3 UBB BRAF UBC PTPN11 RPS27A CBL E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication PPP2CA PPP2CB PPP2R1B PPP2R1A RB1 E2F1 PRIM2 CCNB1 PRIM1 POLA1 POLA2 PPP2R3B TFDP1 CDK1 ORC5 ORC4 TFDP2 ORC6 ORC1 MCM8 ORC3 ORC2 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME ITPA SLC29A3 ADK SLC28A2 SLC29A1 NT5C2 SLC28A3 NME2 PNP ADA NME1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP1A2 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement PSMA5 DOCK1 PSMA6 PSMA3 PSMA4 PSMA1 ARHGEF4 PSMA2 UBA52 PSMD12 PSMD11 RAC1 PSMD14 PSMD13 IL6 TYK2 JAK1 TRAF7 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SRC UBC HACE1 CTNND1 PSMB1 RPS27A ADRM1 CDH1 NFKB1 SEM1 CTNNB1 PSMC5 CBLL1 PSMC6 ELMO1 PSMC3 PSMC4 PSMC1 PSMC2 FARP2 STAT3 TIAM1 CTSL IL6ST RNF19B VAV2 CTSS CTSB JAK2 CTNNA1 JUP CDH11 CDC42 PSMD8 PSMD6 IL6R BIRC2 PSMD7 PSMD2 VCL PSMD3 XIAP PSMD1 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs BTK BAIAP2 ARPC1B ABI2 ARPC1A WASL ABI1 PTK2 WAS RAC1 NCKAP1 ACTG1 NCKIPSD BRK1 CYFIP1 ARPC4 ARPC5 ARPC2 ARPC3 NCK1 ABL1 ACTR3 ACTR2 MAPK1 ACTB CDC42 MAPK3 WASF3 CYFIP2 WIPF1 WIPF2 WIPF3 NCKAP1L WASF1 WASF2 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine ACSM5 ACSM4 GLYAT GLYATL3 ACSM2B GLYATL2 GLYATL1 ACSM2A CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily H2AC6 H2AC7 AXIN2 DKK2 H2AX CHD8 H3-3B H2AC19 H2AC14 H3C8 CHD9 H2BC12L IGF2 H2AJ H2BC26 H2BC21 WDR5 CTNNB1 H3C15 EP300 H2BC17 H2BC12 CHD7 NQO1 H2BC13 NKD2 H2BC14 FAM124B H2BC15 CREBBP H2BC9 CTCF H2BC8 H2BC5 H2BC11 H2BC3 CHD6 H2BC1 H4C9 MAFK NFE2L2 H2AB1 H2AZ2 H2AC20 H2AC8 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion FFAR1 GNA11 GNAQ CD36 GNA14 PLCB3 ACSL4 GNA15 PLCB1 ACSL3 PLCB2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 UBE2N MYD88 IRF7 IRAK1 UBE2V1 TRAF6 TLR9 TLR7 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) EZH2 H2AX PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 H3-3B TEAD4 H3C8 FOS H2AJ YAP1 RRN3 ERCC6 H3C15 RICTOR SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 H2BC1 MBD2 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 BCDIN3D XPO5 DROSHA INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 PRR5 INTS12 GSK3B INTS13 INTS14 DPY30 INTS10 ICE1 ICE2 H2BC26 SSU72 H2BC21 MTREX NABP2 MLST8 NABP1 WDR5 YWHAG ELL2 EED ELL3 PDPK1 ZC3H8 H2BC17 RPRD2 RPAP2 H2BC12 RPRD1B H2BC13 RPRD1A H2BC14 POU2F2 H2BC15 H2BC11 PRKAA1 PRKAA2 LEF1 CAVIN1 RBBP4 RBBP5 RBBP7 TCF7L2 H2AZ2 TCF7L1 DDX21 PTPN11 MTOR TNRC6C TNRC6A TNRC6B CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L ANGPTL4 GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 LPL ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ACTB TP53 PAXIP1 SMARCA5 BAZ1B HCFC1 ARID4B PSIP1 SAP30 SUDS3 SAP30L SAP18 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 PAPOLA SYMPK CXXC1 CPSF4 TGFB1 HSP90AA1 PARP1 ZCCHC8 PABPN1 RBM7 TASOR PPHLN1 RAN CDC73 BLK ELF1 ELF2 CBFB PAX5 SKIC8 RUNX1 CTR9 RTF1 LEO1 PAF1 MTA1 MTA3 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SS18L1 SOX2 ZNF521 TSNAX PRKRA DICER1 TARBP2 TDG TSN TRPC3 PLD6 AGPAT2 ZNF765 ZNF93 ZNF816 ZNF534 PRKCQ ADIPOQ PIWIL2 TDRKH PIWIL1 PIWIL4 DDX4 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 PLIN2 SOX9 YWHAH YWHAZ KIT LIPE HDAC1 DGAT2 POMC UHRF1 FABP4 KDM6A CAV1 TET3 PLIN1 LPIN1 MGLL CGA CPSF7 FURIN RPTOR STK11 DNMT3L SPOCD1 C19orf84 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYA NFYB NFYC GPAM SCD SP1 SSB NFIX NFIA NFIB NFIC CASP1 TP63 CEBPA TNFRSF10B TNFRSF10A ITCH FAS CYCS PDK4 BAX STUB1 OGT PRKACA CAMK2B CAMK2D CAMK2A CAMK2G TFAM EHMT2 TFB2M EHMT1 PAGR1 MAPKAPK5 AJUBA TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM2 MDM4 BMI1 VENTX RING1 MYBBP1A CCNA2 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PHAX SNRPD3 PRMT5 SNRPG SNRPE SNRPF SNRPB RRP8 PHF20 CHEK2 ZNF385A DNMT3B PCBP4 DNMT3A DNMT1 SRRT GRIN2A CAMK4 PLK2 MDC1 SPI1 MT-CO1 RBPJ NOC2L ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 SCO2 ZNF705EP DDIT3 DDIT4 TXNIP MT-CO2 MT-CO3 MYL9 ZNF28 ZNF274 ZNF273 MEAF6 ZNF20 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 ZNF26 SFN ZNF268 PPARGC1B ZNF267 PRELID3A ZNF266 ZNF264 ZNF263 ABCA6 NR2F1 ZNF34 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 BBC3 MED12 MED14 SF3B1 MED13 HEY1 CASP10 MED10 ZNF41 HEY2 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 CNOT6L ACTL6B ZNF480 ACTL6A MED27 MED26 SIRT3 DDB2 MED23 MED25 MED24 MMP13 MED20 ZNF479 ZNF235 ZNF234 ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT EGFR BGLAP PLAGL1 SPP1 ZNF227 ZNF468 ZNF226 KAT8 BID PHLDA1 ZNF225 ACSL1 ZNF224 HCFC2 ZNF223 WDR82 ZNF222 PEX11A MBD3 BOD1L1 ZNF221 MBIP ZNF461 TASP1 ZNF460 KAT14 USP9X DR1 ATAD2 BOD1 ZNF77 CIDEC ZNF79 TADA2A GATAD2B ZZZ3 GATAD2A YEATS2 SKI TADA3 ZNF70 AKAP8L ZNF71 SGF29 ELOVL5 ZNF74 PHF20L1 AGRP ZNF699 PLIN4 MTERF1 ZNF215 KANSL1 EZH1 ZNF214 KANSL2 ZNF213 PHF19 KANSL3 ZNF697 EPOP THRSP ZNF696 PNPLA2 PHF1 ZNF212 JARID2 ZNF454 TET2 ZNF211 TET1 ZNF692 MTF2 ZNF691 IPO8 UBE2D3 EZHIP PSMD8 RORC RORB PSMD6 YY1 PSMD7 SESN3 PSMD2 ZNF208 PSMD3 SESN2 PSMD1 ZNF205 ELAC2 ZNF689 ANG KMT5A ZNF688 ZNF446 SKP1 ZNF445 PITX2 PRKCB ZNF202 PSMA5 ZNF443 PSMA6 ZNF200 PSMA3 ZNF684 PSMA4 ZNF442 PSMA1 ZNF441 PSMA2 BNIP3L ZNF682 UBA52 ZNF440 ZNF681 PSMD12 ZNF680 PSMD11 AFF4 ZFP69B MLLT1 PSMD14 FOXP3 MLLT3 PSMD13 NPAS4 SUPT6H CUL1 MAF IWS1 PSMA7 ZNF439 EAF1 ZNF679 EAF2 RELA ZNF678 PSMB6 ZNF436 PSMB7 ZNF677 PSMB4 ZNF676 PSMB5 ZNF433 ZNF675 UBB PSMB2 ZNF432 PSMB3 PVALB ZNF431 UBC PSMB1 ZNF430 RPS27A GRIA2 KMT2D ADRM1 ZNF671 NFKB1 ZNF670 SEM1 CPAP PSMC5 MAX PSMC6 DLX5 PSMC3 DLX6 PSMC4 KMT2B PSMC1 FOXO6 PSMC2 FOXO4 FOXO1 ZNF840P ATXN3 SOCS3 MED30 MOBP ZKSCAN7 HDAC4 ZNF429 MED31 THRB ZKSCAN8 UBE2I ZKSCAN3 VDR SMYD2 NR1H2 RORA ZNF669 ZNF668 NR3C1 ZNF426 NR2C1 ZNF667 ESR1 ZKSCAN5 ZNF425 ZKSCAN4 NR5A1 ZNF665 NR4A2 AR ZNF664 ZKSCAN1 RXRA SOCS4 SUMO1 BCL2L14 ZNF662 SUMO2 ZNF420 RARA ZNF660 PGR PPARG BRPF1 PPARA BRPF3 TNFRSF10C CD36 FBXO32 MRE11 G6PC1 BRCA1 TNFRSF10D RGCC ZNF419 KAT5 ZNF418 EXO1 ZNF417 ZNF658 ZNF416 CHEK1 ZNF415 NBN PIN1 TOPBP1 ZNF655 SUV39H1 SP7 PPP1R13B COX4I1 COX4I2 RFC5 PTEN RFC3 RMI2 ITGAL PPP1R13L RFC4 ZNF649 ATF7IP DGCR8 SETDB1 YAF2 RFC2 RMI1 NKX3-2 ZNF641 TOP3A TRIM63 HUS1 AEBP2 APAF1 ITGA4 TNFRSF18 RAD51D ARNT RABGGTB DNA2 RABGGTA RHNO1 BLM RRM2B HAND2 ZNF875 PCNA ITGA5 SRF PPM1D WRN ZNF627 ZNF626 BRIP1 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 RBBP8 ATRIP E2F5 ZNF620 BARD1 E2F6 E2F7 E2F8 RPA1 ZNF860 RPA2 PTPN1 MGA TBX5 RAD50 PINK1 RAD51 ZNF619 RPA3 SST IL2RA ZNF616 RAD17 SYT10 RAD1 ZNF615 ATM ZNF614 RAD9B ZNF613 ATR ZNF611 RAD9A PTPN4 ANAPC15 ZNF610 ANAPC16 ANAPC7 TRIM33 SMARCB1 UBE2C CCNC UBE2E1 UXT UBE2D1 LGALS3 ZNF729 ANAPC10 TRIM28 ANAPC11 ZNF727 CCNB1 CDC23 ZNF726 ZNF724 UBE2S CDC26 EPC1 CDC27 CCN2 ZNF721 CDC16 SMARCC1 CDK1 ANAPC4 SMARCC2 ANAPC5 ZFP1 ANAPC1 ZFP2 ANAPC2 ZNF718 ZNF717 ZNF716 SRC ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 ZNF324B CTNNB1 L3MBTL2 FOXG1 MET TGFA ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 YWHAB APOE PCK1 CRADD IQSEC3 MAPK1 SMARCA2 SMARCA4 MPHOSPH8 SNW1 MAPK3 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C MAPK14 CTSL CTSK HNF4A COX8A MAPK11 SREBF1 COX8C PBRM1 SATB2 COX5B COX5A RXRB ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 COX6C GCK ATF2 VEGFA TTC5 CCNG2 CCNG1 HDAC3 MAMLD1 ZFP28 SMARCD3 PRDM7 PRDM1 COX6A1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 XPO1 GTF3C1 COX6B2 GTF3C2 GEM GTF3C3 COX6B1 CRCP ZNF92 GTF3C4 EP300 GPRIN1 GTF3C5 NDRG1 TBL1X GTF3C6 HIGD1C IRAK1 BRF1 TFAP2A POLR3GL PPARGC1A TFAP2B GTF3A NCOA1 ZFHX3 POLR3A TFAP2C MED1 POLR3B NCOA2 TFAP2D POLR3C CREBBP AUTS2 POLR3D MEF2C TFAP2E POLR1C NCOA6 CNOT10 POLR3E IL2 POLR3F IL3 POLR1D BMP2 NR1D1 POLR3G SIRT1 CNOT11 POLR3H BDP1 TCF3 NCOR1 DYRK2 POLR3K TBL1XR1 LDB1 CARM1 CHD4 CHD3 TRIAP1 BMAL1 PIDD1 YWHAQ MYBL2 TGIF1 ZNF75CP RBM14 TGIF2 CAT TMEM219 RETN NFATC2 AURKA INS CALM1 MTA2 RRM2 YWHAE ZNF804B REST JUN KRAS FASLG ZNF175 SOD2 MAML2 CDC25C MAML1 FOXO3 SERPINE1 GLS NAMPT ZSCAN32 MYB PIP4K2A PRDX2 BCL2L11 PIP4K2B JUNB CDK5 ZNF169 RNF111 GAMT PRDX1 ZNF705G ZNF705D ZNF160 CDK5R1 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 NOTCH1 RBX1 ZNF155 ZNF154 ZNF394 NEDD4L NKX2-5 NR2C2AP NFE2 IHH PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 SETD1B SETD1A CDC7 NR1D2 ZNF37A ZNF702P ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET GPI BTG2 RARG BTG1 SETD9 CRH CHM GLI3 GLI2 ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 RSPO3 ZNF124 ZIK1 BRD2 BRD1 TCF12 NCOR2 KAT2B KAT2A SNAPC5 TAL1 SNAPC1 RARB SNAPC2 ZNF599 SNAPC3 ZNF114 SNAPC4 ZNF143 ZNF597 ZNF596 BRF2 ZNF112 ZNF595 ZNF350 GPS2 ZNF589 ZNF347 BRD7 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 WWOX ZNF582 PCGF6 TIGAR PCGF5 PCGF2 WWP1 HIPK1 POU2F1 POU4F1 POU4F2 ZNF33B NCOA3 HIPK2 NR5A2 ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 ITGA2B YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 MEN1 ZNF563 IGFBP1 ZNF562 GAD1 ZNF320 GAD2 ZNF561 USP7 ZNF560 IGFBP3 USP2 NRBP1 KAT6A ZNF559 ZNF317 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 NOTCH2 ZNF793 ZNF551 CSF1R RB1 ZNF792 CDKN1A NOTCH3 CDKN1B ZNF550 CCND3 ZNF791 ZNF790 FZR1 CCND2 NOTCH4 CCND1 ZNF767P E2F1 ZNF549 ZNF548 ABL1 ZNF547 SKP2 DAXX ZNF546 ZNF304 ZNF544 CDK6 ZNF786 TFDP1 CCNE2 ZNF302 ZNF785 TFDP2 LSM10 ZNF543 CDK4 SLBP CCNE1 SKIL LSM11 ZNF300 CDK2 PLXNA4 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC PPP2R1B CNOT4 PPP2R1A CDK8 ZFP69 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 ZNF774 CNOT9 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 SIN3A ZNF528 ZNF764 LBR ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 HDAC2 SMARCD2 PPP2R5C RNF34 GLS2 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 BIRC5 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 AURKB KCNIP3 KLF4 PML ZNF738 PPP2CA MCRS1 ZNF737 PPP2CB ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 TP53AIP1 ZNF607 ACSS3 ZNF606 ZNF605 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 CITED1 POLRMT CITED2 CITED4 PRMT6 KRABD5 KRABD4 PRMT1 MSH2 KRABD3 GP1BA PMS2 SGK1 ZNF2 MLH1 MORC2 ZNF3 NPY ARNT2 ZNF354A ZNF354C ZNF354B STEAP3 LMO1 LMO2 TJP1 KCTD1 OCLN ATP1B4 LIFR KCTD6 FANCD2 COXFA4 NOP2 COX7A2 CCNH COX7A1 RNMT PMAIP1 POLR2A SMAD2 POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E CBX5 POLR2F SMURF2 POLR2G CBX3 POLR2H SMURF1 POLR2I SMAD6 POLR2J ESR2 POLR2K SMAD7 POLR2L NR4A1 RNGTT TP53I3 GTF2H1 NR4A3 GTF2H2 JMY SUPT5H KDM5B GTF2H3 THRA GTF2F1 CGB8 GTF2F2 SLC2A3 GTF2H4 NR2E1 GTF2H5 YBX1 CDK7 CASP6 ERCC3 CASP2 ERCC2 AXIN1 MNAT1 OPRM1 ARID1A ARID1B RBL2 H2AC19 RBL1 H2AC14 IFNG H2BC12L ZNF197 AKT2 ZNF195 MYC NR2C2 AKT3 THBS1 HSPD1 AKT1 ERBB2 HES1 PRKAB2 ZNF189 CSNK2A1 ZNF286A CSNK2A2 ZNF184 PRKAB1 ZNF180 CSNK2B TTF1 OPRK1 SAP130 ARID3A UBTF DEK SAP30BP POLR1A MAPKAP1 POLR1B POLR1E POLR1F POLR1G POLR1H BAZ2A TAF1D TAF1B TAF1C TAF1A WWTR1 YES1 H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 CDKN1A TP53 ZNF385A PCBP4 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease NCBP1 NCBP2 ZMYM2 NRAS STAT1 GAB1 STAT3 HRAS PLCG1 POLR2A FRS2 POLR2B POLR2C TRIM24 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L FGFR2 SOS1 GTF2F1 GTF2F2 FGFR1 FGF1 FGF2 FGF3 CEP43 FGF4 FGF6 FGF7 FGF9 FGF20 STAT5A FGF23 STAT5B FGF22 GAB2 FGF16 FGF18 FGFR3 PIK3CA PIK3R1 FGFR4 FGF10 LRRFIP1 BCR CUX1 FGFR1OP2 MYO18A CPSF6 ERLIN2 BAG4 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade F11 GP1BA PROS1 F5 F8 F10 GP9 FGB GP1BB FGA GP5 GGCX VWF FGG TPST2 TPST1 F2 F9 PROC ANO6 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy ATM USP30 EPAS1 PEX5 UBB NBR1 UBA52 UBC RPS27A SQSTM1 MAP1LC3B SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer MAPK1 MAPK3 PIK3R2 CLIP1 PIK3CA PIK3R1 PIK3CB NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals UNC5A NTN1 UNC5B SRC UNC5C UNC5D PTPN11 DCC MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 RIPK3 PPP2R5D MEF2C TRAF2 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 TP53 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC TUBA4A CCT6A TUBA1C TUBA1A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBA3D TUBA3C CCT8 ACTB CCT7 CCT5 CCT6B CCT4 TUBB6 TUBB3 TUBB1 TUBB4B TUBB4A AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport ADHFE1 D2HGDH L2HGDH GSTZ1 VDAC1 OXA1L COX7B COX7C COX8A COX8C COX5B COX5A COX6C KGD4 HIGD1A DLD COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C COX19 UQCRB COX17 UQCC3 UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH CS LYRM4 UQCRQ LYRM7 UQCRC1 ACO2 UQCRFS1 UQCRC2 CYC1 MT-CYB FXN NDUFS3 TIMM21 SLC25A18 MDH1 NDUFB8 MDH2 SLC25A12 SLC25A11 SLC25A22 SLC25A13 IDH3G NDUFA5 LETM1 ETFB MT-CO1 NDUFAB1 SCO2 MT-CO2 MT-CO3 SLC25A4 PM20D1 RANBP9 SIRT3 ISCA2 ISCA1 CMC1 PYURF SCO1 TMEM126A SUCLG2 WDR26 SUCLG1 GLO1 GOT1 TMEM126B GPT TRAP1 PDHB LDHC SURF1 NDUFAF8 GOT2 RMND5B LDHB NDUFAF6 LDHA NDUFAF7 NDUFAF4 MAEA NDUFAF5 PDPR COX15 NDUFAF2 RMND5A SFXN4 MPC1 NDUFAF3 MPC2 MT-ND6 PDK4 NDUFAF1 CYCS PDK3 UBA52 HCCS PC MT-ND4 TMEM186 MPC1L MT-ND5 NNT NEK1 MT-ND2 RAB5IF ME3 MT-ND3 DLAT ACAD9 MT-ND1 COQ10B ME2 PDK2 COX7A2L COQ10A PDK1 TMEM177 PDHX SDHAF2 ATP5MC2 SDHAF3 ATP5MC3 PDHA2 SDHAF1 ACAT1 FAHD1 SDHAF4 PDHA1 SIRT4 FH ATP5MC1 ARMC8 MT-ATP6 DMAC1 DMAC2 PDP1 PET117 ATP5F1A MKLN1 UBB ECSIT TIMMDC1 GID4 PET100 PDP2 ATP5F1B NUBPL GID8 UBC LDHAL6A LYRM2 LDHAL6B RPS27A NDUFA13 ATP5MK NDUFA11 ATP5MJ NDUFA12 ATP5MG TACO1 ATP5MF NDUFA10 ATP5ME DMAC2L CSKMT SDHC HSPA9 ATP5PF SDHD ATP5PD SDHA SDHB UCP1 NDUFB10 COX16 ATP5PB NDUFB11 COX18 COX11 ATP5F1C COX14 ATP5F1D NDUFV3 MT-ATP8 NDUFV2 ATP5F1E NDUFV1 COA3 ATP5PO COA1 IDH2 COXFA4 HIGD2A COX20 COX7A2 ETFA COX7A1 TMEM223 IDH3B IDH3A COA5 NDUFC2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 COX4I1 SUCLA2 COX4I2 SLC25A27 UCP3 UCP2 SLC25A14 ME1 OGDH DLST REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PARVB LIMS1 PXN ARHGEF6 TESK1 ACTN1 RSU1 PARVA TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 EREG BTC NRG2 HBEGF NRG3 EGFR NRG4 NRAS HRAS EGF ERBB2 NRG1 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 SSR1 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 SRPRA SRPRB RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 SEC11A RPS5 SEC11C RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 DDOST RPS21 SPCS3 RPS24 SPCS2 RPS23 SPCS1 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A SEC61A2 SEC61A1 SEC61G SEC61B SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RPN2 RPN1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) PPP2CA PPP2CB REST JUNB CDK5 RPS6KA1 FOS NAB1 ATF1 NAB2 SH3GL3 ARC CDK5R1 TRIB1 TPH1 RRAD MEF2A DUSP4 EGR3 DUSP3 EGR4 FOSL1 VRK3 ID2 DUSP6 ID3 DUSP7 SGK1 MAPK7 LYL1 F3 VGF ELK1 ASCL1 CDK5R2 MAPK1 MAPK3 ID1 FOSB MAPK14 MAPK11 DNM2 PPP2R1B PPP2R1A MAPKAPK2 EGR2 TCF12 ATF2 RPS6KA5 EP300 ID4 EGR1 MEF2D SRF PPP2R5D MEF2C RPS6KA3 RPS6KA2 CHD4 JUND RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT MYH9 RHOB RHOC CIT MYL12B PPP1CB CDKN1B PPP1R12A PPP1R12B MYH11 RAC1 KIF14 PRC1 MYH14 MYH10 DLG4 MYL6 RHOA MYL9 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP2E1 CYP2F1 CYP24A1 PTGIS TBXAS1 CYP4F12 CYP8B1 ADH7 ARNT2 POMC CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 RXRA CYP19A1 CYP51A1 CYP26A1 CYP26B1 CYP26C1 FDX1 FDXR FDX2 ARNT CYP11B2 CYP46A1 CYP21A2 CYP39A1 POR CYP2U1 CYP27B1 CYP4F2 CYP11B1 NCOA1 CYP4A11 CYP11A1 CYP4V2 CYP1B1 NCOA2 CYP2R1 NR1H4 CYP7B1 CYP7A1 CYP27A1 CYP2J2 CYP3A43 AHR FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism ALDOB ALDH1A1 TKFC GLYCTK AKR1B1 KHK SORD DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production MYD88 RELA IRF7 DHX9 DHX36 NFKB1 NFKB2 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction KCND2 SCN11A KCND3 GATA4 SCN9A SCN1B SCN1A SCN10A KCNA5 SCN8A KCNJ14 SCN3B SCN3A KCNK6 KCNK2 KCNK7 KCNK1 KCNK3 KCNK4 SCN2A SCN2B SCN5A SCN4A SCN4B SCN7A CACNA2D2 CACNA1C CACNG6 NPPA FGF14 RANGRF FGF13 FGF12 FGF11 CACNB1 CACNB2 CACNG8 NPR1 NPR2 NPPC KCNJ2 CACNG4 CORIN KCNJ4 KCNJ12 KCNIP3 CALM1 NKX2-5 KCNK5 KCNK12 KCNK15 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 AKAP9 RYR3 SLC8A2 SLN NOS1 CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 KCNE1 ATP1B1 KCNE2 KCNE3 TRDN KCNE4 ASPH STIM1 KCNE5 ORAI2 ORAI1 KAT2B CAMK2B CAMK2D CAMK2A MME ATP1A4 ITPR1 ATP1A3 CES1 ITPR2 ATP1A2 ITPR3 ATP1A1 SRI PLN TNNI3 CACNG7 CAMK2G KCNJ11 DMPK ATP2B4 ATP2B3 ATP2B2 KCNH2 ATP2B1 SLC8A3 FXYD4 FXYD3 FXYD2 KCNK10 FXYD1 KCNIP1 KCNIP2 FKBP1B FXYD7 KCNIP4 KCNK13 FXYD6 KCNK16 KCNK17 KCNK18 KCNQ1 HIPK1 WWTR1 HIPK2 TRPC1 TBX5 KCNK9 KCND1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors FFAR1 GPR31 FFAR4 FFAR3 FFAR2 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 NTF4 PLCG1 NTRK2 BDNF POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events PRKAG1 CALM1 PRKAG2 PRKACG PRKAG3 PRKACB RAC1 RPS6KA1 SRC GRIA2 NRAS MAPK1 HRAS GRIN2B MAPK3 RPS6KA6 KPNA2 PRKAR1B GRIA1 PRKAR2B PRKACA PRKX RASGRF2 CAMK2B ADCY1 RASGRF1 ACTN2 CAMK2D ADCY8 CAMK2A GRIN2C NRGN PRKAR2A GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 PRKAR1A CAMK4 NEFL NRG1 CAMK1 PRKAB2 CAMK2G PRKAB1 CAMKK1 CAMKK2 PDPK1 GIT1 PRKAA1 RPS6KA3 PRKAA2 RPS6KA2 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants HSP90AA1 CDC37 ERBIN ERBB2 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins UBA52 TSG101 NMT2 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 UBB VPS28 UBC RPS27A ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors ADCYAP1R1 NTRK1 NGF NTRK2 ADCYAP1 ADORA2A NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development WT1 LHX1 JAG1 LFNG HNF1B DLL1 IRX1 IRX2 WNT9B POU3F3 HNF4A WNT4 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 NOTCH3 PSENEN PSEN2 PSEN1 APH1A YBX1 NCSTN APH1B ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAG1 PRKAG2 CAB39L RPTOR STK11 PRKAG3 STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD CAB39 SLC38A9 RHEB LAMTOR2 PRKAB2 LAMTOR1 LAMTOR4 MLST8 LAMTOR3 PRKAB1 LAMTOR5 PRKAA1 PRKAA2 MTOR NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway HDAC10 HDAC11 MAML2 MAML1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 NOTCH1 NOTCH2 TBL1X NOTCH3 RBPJ HDAC5 HDAC1 HDAC2 NOTCH4 CREBBP HDAC4 HDAC8 HDAC9 HDAC6 NCOR1 HDAC7 TBL1XR1 SNW1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 SSB GTF3C2 NFIX GTF3C3 NFIA CRCP NFIB GTF3C4 NFIC GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules MAGT1 STEAP4 TFRC RHCG RHBG HFE SLC40A1 TCIRG1 HEPH SLC22A17 FTH1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 DERL3 ATP6V0E1 DERL1 ATP6V1G2 DERL2 SLC5A8 GLRX3 ABCB7 ATP6AP1 SLC11A2 TFR2 OS9 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 FTL PLEKHA8 ABCG2 ATP6V1B1 ATP6V1A IREB2 NEDD8 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 TUSC3 ATP6V1F ATP6V1C2 ATP6V0A1 CYBRD1 CP TF LCN2 ACO1 VCP SLC9A2 SLC9A3 SEL1L SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 RNF185 STOM SLC2A8 RNF5 ERLEC1 AQP9 AQP7 HDLBP PCSK9 SLC25A18 AP2A1 EIF2S3 LIPA AP2A2 LIPC EIF2S2 CREB3L3 SLC25A11 EIF2S1 PRKACG SLC25A22 LIPG LDLRAP1 PRKACB AP2M1 MYLIP SLC35A3 CUBN AMN SLC43A2 APOA2 SLC1A1 SLC2A9 APOA4 SLC43A1 SLC1A2 LSR APOA5 RSC1A1 SLC3A1 NPC1 SLC1A3 SLC2A2 SLC5A1 SOAT1 SLC1A4 SOAT2 SLC3A2 SLC6A3 NPC2 SLC1A5 ANGPTL8 SLC7A11 ANGPTL3 SLC1A6 ANGPTL4 SLC6A20 SLC7A10 LPA CES3 SLC1A7 ABCD1 SLC7A1 ABCG1 SLC7A3 CETP SLC25A29 MTTP SLC38A3 SLC67A1 LCAT SLC36A4 LPL SLC38A2 LMF2 SLC38A5 LMF1 AP2S1 SLC38A4 SLC36A1 APOF SLC6A19 A2M LDLR SLC38A1 GPIHBP1 SLC36A2 SLC6A15 FGF21 ABCA1 SLC6A14 APOC4 SLC6A12 SLC16A10 NR1H3 SLC6A6 APOBR SLC7A5 APOC3 SLC7A6 AP2B1 SLC7A7 NCEH1 SLC7A8 APOC2 SLC7A9 APOC1 ALB P4HB SLC35B3 SLC35B2 ZDHHC8 ADCY9 PRKAR1B PRKAR2B ADCY4 ARL2 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SLC35D2 FBXL5 SLC47A2 SLC22A4 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 PEX19 SLC22A16 SLC17A5 ABCA6 SLC25A5 SLC25A4 SLC25A6 SLC2A13 SLC5A11 ADD1 SLC5A3 ADD3 SLC26A11 SLC35D1 SLC26A2 SLC26A1 ABCA12 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 ABCB6 ABCB4 SLC5A2 SLCO1B1 SLCO1B3 SLC33A1 SLC6A5 SLC26A4 SLC26A3 SLC12A2 SLC6A2 SLC12A3 SLC12A4 SLC22A12 SLC2A10 SLC12A5 SLC2A1 SLC12A1 ABCC6 SLC12A6 CYGB SLC29A3 SLC12A7 SLC24A4 SLC20A2 SLC35A2 SLC16A1 SLC24A5 CLTC CLTA SLC4A7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SLC25A10 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 SLC24A1 PSMB6 PSMB7 RUNX1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SLC5A6 SLC6A7 ADRM1 SLC6A9 SLC17A6 SEM1 PSMC5 PDZD11 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SLC15A1 CTNS SLC15A3 SLC15A4 NR1H2 ABCC1 ABCG8 ABCG5 CLCN6 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 ATP11C ATP11B PRKAR1A ATP11A SLC9B1 SLC22A3 ABCB1 SLC9B2 SCNN1G SCNN1D AQP8 SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA TRPM1 NALCN TRPM2 ASIC4 TRPM7 ASIC5 CLCA2 TRPM8 CLCA1 TRPM5 SLC4A2 TRPM6 ASIC2 SLC4A3 TRPM3 ASIC3 SLC4A5 CLCA4 TRPM4 SLC5A9 TRPC7 ASIC1 SLC60A2 ATP8B4 MCOLN3 SLC30A10 ATP8B3 TRPC5 SLC5A4 ATP8B2 TRPC6 ARL2BP ATP8B1 TRPC3 SLC2A14 TRPA1 ATP4B SLC2A11 TRPC4 ATP4A ABCC3 SLC2A12 TRPC1 WNK1 NIPA1 WNK2 TRPV2 SLC39A10 WNK3 TRPV3 NIPA2 CUTC TRPV1 SLC39A14 UNC80 MCOLN1 SLCO4A1 ATP7B MCOLN2 SLC29A4 ATP7A TRPC4AP SLC17A1 TSC22D3 TRPV6 DMTN ANO8 TRPV4 SLCO4C1 ANO9 TRPV5 SLC28A1 ANO6 SLC27A1 ANO7 SLCO2B1 ANO4 SLC39A6 ANO5 SLC39A5 ANO2 SLC39A8 ANO3 SLC39A7 ANO1 SLC16A2 SGK3 SLC39A2 SGK2 SLC39A1 STOML3 SLC39A3 ATP10D SLC27A6 ATP10B LCN9 ATP10A SLC4A10 ATP2C2 PIP CLCN3 LCN1 ATP2C1 SLC26A7 CLCN2 SLC26A9 CLCN1 SLC26A6 BSND ANO10 SLC25A1 MB ATP9B SLC17A3 SLC13A1 SLC13A2 ATP9A SLC13A3 ATP13A1 SLC13A4 TPCN2 NGB TPCN1 SLCO1C1 CLCN7 SLC5A12 CLCN5 SLC5A10 STOML2 CLCN4 OSTM1 LRRC8C MCUB LRRC8D SPG7 ATP13A4 PHB2 LRRC8A ATP13A5 MAIP1 LRRC8B ATP13A2 SLC8B1 SLC13A5 UNC79 LRRC8E PARL GLTP AKAP1 AHCYL2 AFG3L2 SMDT1 SLC35B4 AQP6 VDAC3 AQP4 VDAC2 YME1L1 AQP5 PMPCB AQP2 PMPCA AQP3 NIPAL4 MICU3 NIPAL1 VDAC1 NIPAL2 MICU2 NIPAL3 MICU1 MCU SLC11A1 APOE AZGP1 MIP SLC22A6 SLC45A3 ANKH LCN15 LCN12 RAB11FIP2 MYO5B MRS2 SLC22A11 SLC20A1 SLC66A1 SLC31A1 ESYT3 ESYT2 SLC30A3 SLC30A2 MMGT1 SLC30A1 SLC41A2 SLC41A1 AQP10 SLC2A6 SLC2A7 AQP12A CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 AQP11 SLC46A1 RAB11A HBB HMOX1 APOB SLC2A4 APOA1 HBA2 SLC16A7 SLC16A8 CFTR EMB SLC16A3 CALM1 SLC24A2 LETM1 SLC24A3 SLC44A5 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 ESYT1 SLC44A2 NEDD4L ABCD2 ABCD3 ABCC10 ABCC11 ABCA10 PEX3 GNGT1 ABCG4 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 GNGT2 ABCA5 ABCA4 ABCA9 ABCA7 ABCA8 ABCB10 SLC5A5 ABCC4 ABCA3 ABCC5 GNG10 PRKAR2A GNG3 CYB5R2 CYB5R1 SLC28A2 GNG2 SLC29A1 CA1 CYB5R4 GNG5 CA2 GNG4 SLC29A2 CA4 GNG7 SLC4A1 SLC28A3 GNG8 CYB5RL RHAG AQP1 WWP1 GNG12 GNG11 GNG13 APOD GNB2 GNB1 GNAS GNB4 GNB3 GNB5 SLC35C1 FURIN PCSK6 PCSK5 SLC35A1 SLC34A3 SLC34A2 SLC34A1 ARF1 SAR1B MBTPS1 SLC6A13 SLC6A11 SLC22A2 SLC22A1 SLC6A1 SLC6A4 MBTPS2 SLC32A1 SLC17A7 ABCC2 SLCO1A2 SLC22A8 SLC22A5 VLDLR SGK1 AVPR2 AVP STEAP3 RYR1 RYR2 SLC17A8 ATP2A3 ATP2A2 ATP2A1 SLC8A1 RYR3 SLC8A2 SLN CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 SLC2A3 TRDN ASPH CAMK2B CAMK2D SLC30A8 CAMK2A ATP1A4 SLC30A5 ATP1A3 ATP1A2 ATP1A1 SRI PLN CAMK2G KCNJ11 ATP2B4 ATP2B3 ATP2B2 ATP2B1 PHB1 SLC8A3 FXYD4 FXYD3 FXYD2 FXYD1 FKBP1B FXYD7 FXYD6 ERLIN1 RAF1 ERLIN2 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases H2AX RAC1 MTMR1 H3-3B TFRC H3C8 VAV1 H2AJ SCFD1 H3C15 ATP6AP1 PAK1 PAK3 PAK2 KLC1 KLC4 H2BC9 KLC3 H2BC8 KLC2 H2BC5 DOCK3 H2BC3 FRS3 H2BC1 TIAM1 HMOX2 H2AB1 H2AC8 H2AC6 H2AC7 JAG1 VCP ITSN2 DBT RTKN SOWAHC ARHGEF10L STK10 AKAP13 SLK H2BC26 H2BC21 ARHGEF11 ARHGEF10 NCKAP1 ARHGEF12 NCF1 YWHAG ARHGEF17 STARD8 NCF2 NCF4 RHOB PDPK1 CIT SNAP23 H2BC17 DAAM1 BRK1 ARHGAP6 ARHGEF3 H2BC12 ARHGEF1 DOCK10 H2BC13 ARHGEF2 SYDE1 H2BC14 PKN3 ARHGAP42 H2BC15 PIK3CA BAIAP2L1 ARHGEF25 PICALM RAC3 ARHGEF28 IQGAP3 LCK GIT1 SWAP70 STOM RHPN2 ARAP2 H2BC11 CYBB ECT2 STARD13 ARAP3 JUP OCRL CAVIN1 CYBA BCR CDC42 PCDH7 AMIGO2 MYO9A NET1 CTTN NOXO1 ANLN ARHGAP17 ARHGAP15 DIAPH1 ABR CSK ACTC1 RACGAP1 DLC1 PKN2 SLITRK3 PKN1 NHS H2AZ2 TNFAIP1 SLITRK5 RND3 NCKAP1L CKB WASF1 SEMA4F WASF2 ARHGEF40 CKAP4 NISCH PLEKHG2 IL32 KCTD13 GIT2 ARHGEF15 PLEKHG5 TRIP10 ARHGAP26 BAIAP2 ARHGEF19 TAOK3 RHOC ABI2 TIAM2 OBSCN NOXA1 ABI1 ARHGEF4 NOX3 ARHGEF7 NGEF NOX1 FERMT2 ARHGEF6 FGD1 C1QBP FGD2 GNA13 FGD3 FGD4 ARHGEF39 PLXNB1 SLC1A5 KLK3 KLK2 KDM4C RHOU GJA1 ACTB PTK2B CYFIP2 WIPF1 SCAI WIPF2 WDR91 WIPF3 ANKFY1 WDR81 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 BTK GMIP CDC42EP5 CDC42EP4 CDC42EP3 ARPC1B CDC42EP2 ARPC1A FGD5 CFL1 CHN2 WASL CHN1 FARP1 DEF6 WDR11 VMA22 WAS SHKBP1 GOPC ROPN1 FILIP1 TAX1BP3 FAM13B NF2 CCT6A FAM13A PRC1 POTEE GOLGA8R RALGAPA1 FAM91A1 TEX2 ARMCX3 DDRGK1 TUBA1B NSFL1C ARHGAP11A ZNF512B ARHGAP11B TAGAP CCT2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 MYH9 ARFGAP2 BLTP3B NCKIPSD DVL1 SH3BP1 DVL2 WHAMM DVL3 GOLGA3 BAIAP2L2 SPATA13 ARPC4 TMEM87A ARPC5 FAF2 ARPC2 AKAP12 ARPC3 HINT2 CTNNA1 GRB7 SH3PXD2A STMN2 RHOH ACTR3 KIF14 RHOF ACTR2 RHOD RND1 STIP1 RHOV EPSTI1 PLEKHG4B WDR6 EMC3 CCT7 PLXNA1 PRAG1 PLXND1 WASF3 SYDE2 FAM83B ANKRD26 ARHGAP44 DST DOCK11 RRAS2 BCAP31 ARHGAP40 BASP1 ALDH3A2 TMEM59 RALBP1 CCDC88A KCTD3 PREX2 MYL9 FAM135A ARHGAP45 VANGL2 ARHGAP19 ARHGAP18 UBXN11 AAAS TOR1AIP1 DLG5 CPD ARHGAP12 WWP2 PKP4 ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 SFN ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 LIN7B RASGRF2 USP9X ARHGEF9 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 FMNL3 HSP90AA1 PRKCB ARHGAP39 SRGAP3 LIMK2 SRGAP2 LIMK1 SRGAP1 MYH14 MYH10 DOCK7 MRTFA SENP1 SRRM1 PTPN13 AR DDX39B PRKCA PIN1 CCP110 CEP97 ARHGAP10 SRF PLK1 SRC STAM CDH1 HGS CTNNB1 STAM2 YWHAB FARP2 MAPK1 PLD2 MAPK3 KIDINS220 FRS2 MAPK14 MAPK11 RAPGEF1 SOS1 PARD6B ARHGEF18 PRKCZ RHOA PARD6A XPO1 PGRMC2 ARL13B DDX4 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO NCOA2 ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L CFTR ARHGDIB EMD TMPO PLEKHG3 YWHAQ ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 CALM1 ARHGEF5 RAB7A EPHA2 YWHAE VAMP3 ARHGEF26 PPP1R12A GARRE1 SHMT2 PPP1R12B CDC25C PPP1R14A PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 LMNB1 STX5 YKT6 PAK4 NDUFA5 MCF2 MCAM ERBIN YWHAH HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 YWHAZ PPP1CB ABCD3 RAC2 S100A9 S100A8 CAV1 VAV3 PTK2 PFN1 VAV2 FLNA PFN2 UACA HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 PAK6 MSI2 PAK5 RHOBTB1 MYO9B ACTG1 RHOBTB2 TRA2B MYO6 ABL2 STK38 RBBP6 RNF20 SPEN CPSF7 KDM1A TMOD3 NCK2 ACTN1 NCK1 TXNL1 COPS4 COPS2 EVL CDC37 PHIP SOS2 PDE5A VIM HNRNPC RBMX DBN1 CUL3 RASAL2 MEN1 SPTBN1 LAMTOR1 MYLK MYL12B CDKN1B SPTAN1 MYH11 ABL1 TPM4 TPM3 MYL6 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MTR MAD1L1 CDCA8 MUC13 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 DLG4 PIK3R4 RCC2 NDC80 ZWINT LBR KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 FLOT1 NDEL1 SEC13 NUDC FLOT2 NUP133 PIK3C3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SAMM50 SPC24 MAD2L1 CENPS NUP37 SPC25 MTX1 SH3RF1 STEAP3 DSP DSG1 DSG2 CAPZB TJP2 PRKCD KIF5B KIF5A H2AC19 H2AC14 H2BC12L PIK3R3 IQGAP1 PIK3R2 PIK3R1 H4C9 ZAP70 MAP3K11 H2AC20 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling NTRK3 NTF3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis NRIP1 NR1H2 FASN RXRB ANGPTL3 RXRA NR1H3 SCD SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 VAMP3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 HLA-B SEC22B PSMA7 MYD88 HLA-A B2M PSMB6 PSMB7 PSMB4 PSMB5 UBB CD14 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSME1 PSME2 SEM1 PSMC5 PSMC6 PSMB10 PSMC3 PSMC4 PSMC1 PSMB8 PSMC2 PSMB9 TAP2 S100A9 TAP1 S100A8 SEC61A2 SEC61A1 SEC61G SEC61B TAPBP STX4 BTK VAMP8 S100A1 CD36 TIRAP HLA-H HLA-C HLA-F LY96 HLA-G HLA-E HMGB1 TLR1 SNAP23 TLR6 CALR TLR2 PDIA3 FGB FGA FGG PSMD8 IKBKB TLR4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) NTRK3 SOS1 BAX PIK3R1 PIK3CA NELFB NRAS PTPRS PTPRO HRAS NTF3 IRS1 PLCG1 SRC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins PRKAR2B PRKACA PRKACG ADCY4 PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A RAB11A ADCY5 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1A AQP1 AQP4 AVPR2 AQP2 AQP3 AVP GNGT1 GNGT2 GNG12 GNG11 GNG13 RAB11FIP2 GNB2 MYO5B GNB1 GNAS GNB4 GNB3 GNB5 ADCY9 PRKAR1B CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes ATF4 ATF6 CALR DDIT3 NFYA NFYB NFYC HSPA5 HSP90B1 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints MCM6 RAD1 ATM MCM2 RAD9B ATR H2AX RAD9A SFN CCNB1 CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 H2BC9 H3-4 YWHAB H2BC8 H2BC5 H2BC3 H2BC1 CDK2 CDC6 CCNB2 H2BC26 H2BC21 UBE2N YWHAG H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 YWHAQ PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 HERC2 YWHAE PSMA4 PSMA1 PSMA2 UBA52 CHEK2 GTSE1 CDC25C PSMD12 PSMD11 CDC25A PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 YWHAH PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 MCM10 YWHAZ PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PKMYT1 PIAS4 WEE1 CDC7 BRCC3 CLSPN TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 UBE2V2 TOP3A HUS1 DNA2 MDC1 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 CDC45 MCM7 RAD50 RPA3 MCM3 MCM4 RAD17 MCM5 MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy TBK1 TOMM40 UBE2V1 UBA52 MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN UBC RPS27A TOMM70 CSNK2A1 CSNK2A2 TOMM20 UBE2L3 TOMM22 CSNK2B UBE2N MAP1LC3A FUNDC1 MTERF3 ATG9A VDAC3 ATG12 VDAC2 ATG5 VDAC1 UBE2D2 SQSTM1 UBE2D3 PRKN PINK1 ULK1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling UBE2D1 RAC1 FOS VAV1 MAPK9 MAPK8 PAK1 PAK2 MAPK10 UBE2D2 IGHV3-23 NRAS IGLV IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 HRAS IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 GRAP2 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ SOS1 UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 FCER1A IGLV1-47 IGLV6-57 MS4A2 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 PDPK1 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 TXK IGKV3D-20 V5-6 FYN TRAF6 IGHE PPP3CA IGLV3-19 PPP3CB IGKV2-30 IGHV2-70 RASGRP1 IGHV2-5 IGLV3-1 PPP3R1 IGHV3-48 NFATC3 IGLV3-25 NFATC2 IGLV3-27 NFATC1 IGKC IGLV3-21 CALM1 FCER1G IGKV1-39 IGKV1-33 V4-6 IGHV3-53 JUN V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 BTK PLCG2 VAV3 SYK VAV2 GAB2 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TEC MAP3K1 AHCYL1 ITPR1 ITPR2 ITPR3 PIK3R2 PIK3R1 LYN MAP2K4 ITK LCP2 LAT2 MAP2K7 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint CDK1 CCNB2 CCNA2 PKMYT1 CCNA1 WEE1 CCNB1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 TP53 PSMD12 PSMD11 COP1 PSMD14 PSMD13 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins VKORC1L1 PLB1 LRP1 LRP8 UBIAD1 APOM AKR1C3 GPC1 HSPG2 GPC3 GPC2 BCO2 APOA2 SDC4 APOA4 SDC2 RDH11 GPC5 BCO1 SDC3 GPC4 LRP10 GPC6 AKR1B10 LRP12 AGRN LPL TTPA APOB SDC1 LDLR LRAT GPIHBP1 APOE APOA1 APOC3 AKR1C1 APOC2 TTR AKR1C4 RBP4 LRP2 RBP2 VKORC1 CLPS RBP1 RETSAT PNLIP SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 SOS1 PRKCE UBA52 STUB1 MEMO1 PRKCD PRKCA NRG2 NRG3 EGFR NRG4 ERBIN AKT2 UBB AKT3 RHOA SRC UBC ERBB2 AKT1 RNF41 NRG1 RPS27A CUL5 USP8 MATK PTK6 EREG PIK3R1 BTC PIK3CA SHC1 HBEGF GRB7 NRAS HSP90AA1 GAB1 CDC37 HRAS YES1 PLCG1 FYN PTPN18 EGF DIAPH1 PTPN12 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation DDX46 DDX42 RBM17 SMNDC1 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 PHF5A SNRPN CHERP PTBP1 SNRPA1 DNAJC8 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 TCERG1 SRRM2 SNRPG SNRPC SRSF8 SNRPA SNRPE HTATSF1 CPSF4 RBM25 PPP1R10 SNRPF SNRNP70 PRPF40A SNRPB TUT1 PPP1R8 SRSF10 SRSF12 RBM39 HNRNPH1 HNRNPH2 RBM5 PABPN1 PAPOLG UBA52 NCBP1 NCBP2 UBB UBC RPS27A FIP1L1 PPP1CB HNRNPU PPP1CA CDC40 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SRSF9 XRN2 GTF2F1 GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 SRSF11 SRRT FUS HNRNPA1 HNRNPA3 TRA2B RBBP6 CCAR1 PCBP1 CPSF7 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC RBMX DHX9 HNRNPA2B1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense PIM1 GBP1 CASP1 SFN INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation EEF2KMT EEF2 RPS2 CALM1 VCP CAMKMT KIN ETFBKMT PRMT3 ETFB METTL22 METTL21A VCPKMT EEF1AKMT2 HSPA8 EEF1A1 EEF1AKMT1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAL ADCY4 ADCY3 ADCY9 ADCY2 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis DHRS7B GNPAT AGPS MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors PPARG MEF2C RBFOX1 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling AKT2 PDE3B THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome NLRP1 BCL2 BCL2L1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin MCM6 MCM2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 ORC5 PSMB7 ORC4 PSMB4 ORC6 PSMB5 ORC1 UBB MCM8 PSMB2 CCNA2 PSMB3 ORC3 CCNA1 ORC2 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SKP2 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 MCM7 PSMD3 PSMD1 MCM3 MCM4 SKP1 MCM5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance CEP83 DYNLRB2 DYNLRB1 IFT25 CEP89 PRKAG1 CEP57 PRKAG2 ARF4 C2CD3 CETN2 PLK1 CEP164 PKD2 PRKAG3 PKD1 IFT52 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CNGA2 BBS9 CDK1 CNGA4 BBS7 TNPO1 IFT57 CEP290 NINL IFT56 BBS5 CC2D2A BBS4 RAB8A OFD1 DYNLT5 IQCB1 MKKS EXOC8 DYNLT2 IFT140 EXOC7 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 RP2 BBS12 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 MAPK14 EXOC5 NEK2 IFT46 MAPK12 SFI1 EXOC2 MAPK11 SDCCAG8 EXOC1 IFT70B IFT70A DCTN2 SSNA1 DCTN3 DYNLT2B ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 ATF2 CEP152 WDR19 CRTC2 GBF1 CSNK1E HDAC3 SCLT1 RAB11A CRTC3 ATAT1 SMARCD3 NEDD1 CRTC1 TTC8 CHD9 ALMS1 TRIP11 CEP162 B9D1 HELZ2 CEP41 CEP43 CLUAP1 TGS1 YWHAG ARL13B INPP5E GLUD1 TBL1X GLUD2 PDE6D GABPA SIRT5 MEF2D PPARGC1A PPRC1 NCOA1 PERM1 MED1 NCOA2 CREBBP MEF2C NCOA6 NR1D1 PRKAA2 NCOR1 TBL1XR1 CARM1 CALM1 YWHAE SOD2 SMO PRKAR2B TUBA4A TUBA1A CAMK4 CCT3 CCT2 HCFC1 TCP1 TFB1M CCT8 CCT5 CCT4 TUBB4B TUBB4A PPARGC1B SIRT3 ESRRA PPP2R1A KIF17 MTERF1 DYNLL1 HSP90AA1 CKAP5 DYNLL2 HDAC6 MAPRE1 PAFAH1B1 DYNC1I2 ALAS1 CLASP1 CYCS DYNC1H1 NDE1 ATP5MC2 ATP5MC3 MICOS13 RHO MICOS10 SIRT4 ATP5MC1 MT-ATP6 B9D2 APOO CNGB1 ATP5F1A CHCHD3 SAMM50 ATP5F1B POLRMT CHCHD6 POLG2 ACSS2 ATP5MK ATP5MJ ATP5MG ATP5MF CPAP ATP5ME DMAC2L TWNK HSPA9 ATP5PF ATP5PD MTX1 APOOL SSBP1 MTX2 ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D MT-ATP8 ATP5F1E TMEM11 ATP5PO IDH2 RXRA AKAP9 PPARA PRKACA DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CCP110 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CEP131 CSNK1D IFT80 CYS1 RPGRIP1L LZTFL1 PRKAB2 IFT88 IFT81 UNC119B PRKAB1 ARL6 ARL3 FBF1 MCHR1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B CEP70 NPHP1 TFAM CEP72 TFB2M NPHP3 CEP192 NPHP4 KIF3C MARK4 CEP76 RAB11FIP3 CEP78 PLK4 BBS2 BBS1 ODF2 RAB3IP IFT122 BBIP1 IFT20 AHI1 IFT22 MKS1 NRF1 IFT27 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization LAMB3 EZH2 H2AX CDH4 LAMA3 LAMC2 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B CLDN2 H3C8 MTBP ZC3H12A CSNK2A3 CLDN6 H2AJ CLDN4 CLDN3 SRC CLDN9 CTNND1 CLDN8 CLDN7 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 CLDN22 CLDN20 ZMYM2 CLDN23 RACK1 CLDN11 CLDN10 CLDN15 CLDN14 SUZ12 CLDN12 H2BC9 CLDN19 H2BC8 CLDN18 H2BC5 CLDN17 CLDN16 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST SDK1 H2AC8 SDK2 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 PARD6G PARD6B MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 PXN PATJ F11R COL17A1 PALS1 ZEB1 CRB3 PARD6A PARD3 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 ITGB1 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 RBBP7 H2AZ2 TGIF2 TNRC6C DOCK1 TNRC6A TNRC6B ARHGEF4 FERMT2 ARHGEF6 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PRKCSH SNAI2 GANAB CD151 MOGS TCF12 VAV2 FLNA VASP PRDM8 BHLHE22 KDM1A CDH8 ACTN1 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 CLDN5 SNAI1 DST TESK1 ZNF217 RSU1 PARVA PARVB FLNC LIMS2 FURIN PCSK6 LIMS1 FBLIM1 ANK3 ILK TYK2 PLEC RB1 POMT2 DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 ITGB4 ITGA6 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PRKCI PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CLDN1 RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 JAK2 H4C9 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism SUMO2 UBE2I VDR CYP27B1 CYP24A1 LRP2 GC LDLRAP1 LGMN PIAS4 CUBN CYP2R1 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs NEIL3 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions PTPN6 TYROBP PTK2B CD47 FYB1 SIRPG SIRPA PTK2 SIRPB1 PTPN11 SKAP2 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations B3GALNT2 POMT1 POMK POMGNT2 DAG1 POMT2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 EIF4E EIF4B EIF4G1 EIF4A2 EIF4A1 EIF4A3 CNOT6L CNOT4 CNOT6 CNOT7 HBS1L TNKS1BP1 NT5C3B CNOT1 SKIC3 CNOT2 DCPS CNOT3 CNOT8 DDX6 LSM1 CNOT9 LSM5 LSM4 LSM3 PATL1 EDC3 LSM2 EDC4 LSM7 TUT7 PABPC1 LSM6 XRN1 TUT4 DCP1A DCP2 DCP1B SKIC2 PAIP1 PAN2 PAN3 CNOT10 CNOT11 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors ADCYAP1R1 GIPR GHRHR GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GLP1R VIPR1 VIPR2 SCT GCGR GNGT1 SCTR GNGT2 GCG GNG12 GNG11 GNG13 GNB2 GLP2R GHRH GNB1 GNAS GNB4 GNB3 GIP GNB5 ADCYAP1 VIP DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage APRT DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 GFPT1 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID CHUK NFKBIA RELA IKBKB IKBKG NFKB1 NFKB2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 DNA2 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR EIF2AK2 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription EZH2 H2AX H3-3B TWIST2 TWIST1 H3C8 H2AJ H3C15 ZMYM2 HDAC1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 H2BC1 SMARCA4 MPHOSPH8 MAPK3 FOXQ1 SNAI2 H2AB1 TLE1 ZBTB33 H2AC8 H2AC6 PKM H2AC7 MCRIP1 TCF12 H2AC19 H2AC14 H2BC12L ZEB2 ZEB1 H2BC26 H2BC21 CTBP2 CTBP1 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 KDM1A HDAC2 H2BC11 SIRT1 TCF3 H4C9 SNAI1 RBBP4 RBBP7 H2AZ2 H2AC20 KMT5A ZNF217 TGIF2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PPP2R1B PPP2R1A PFKFB1 PPP2R5D MLXIPL RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib HSP90AA1 CDC37 ERBIN ERBB2 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2AX MTA2 H3-3B TBP H3C8 MYBBP1A H2AJ ERCC6 H3C15 MTA1 HDAC1 SF3B1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 ACTB H2BC1 H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L KAT2B KAT2A H2AC19 H2AC14 H2BC12L GSK3B SMARCA5 MBD3 H2BC26 H2BC21 BAZ1B TTF1 EP300 GATAD2B DEK GATAD2A H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 EHMT2 POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 DDX21 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing NTHL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ELMO2 DOCK1 ELMO1 PTK6 RASA1 CRK RAC1 ARHGAP35 NRAS HRAS PXN RHOA BCAR1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors P2RY10 LPAR6 P2RY2 P2RY11 P2RY4 P2RY1 P2RY12 LPAR4 P2RY13 GPR17 P2RY14 P2RY6 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis AKR1B1 SORD SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport SLC27A1 SLCO2B1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC16A2 SLC39A2 SLC39A1 SLC39A3 SLC27A6 LCN9 SLC4A10 LCN1 SLC26A7 SLC26A9 SLC26A6 SLC25A1 SLC13A1 SLC13A2 SLC40A1 SLC13A3 SLC13A4 HEPH SLCO1C1 SLC5A12 SLC5A10 SLC8B1 SLC13A5 SLC5A8 AHCYL2 SLC11A2 SLC35B4 SLC11A1 SLC22A6 SLC45A3 LCN15 LCN12 SLC22A11 SLC20A1 SLC31A1 CP SLC30A3 SLC30A2 SLC30A1 SLC41A2 SLC41A1 SLC2A6 SLC9A2 SLC2A7 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC50A1 SLC9A8 SLC4A8 SLC9A9 SLC4A9 SLC9A1 SLC2A4 SLC2A8 SLC16A7 SLC16A8 EMB SLC16A3 CALM1 SLC25A18 SLC25A11 SLC25A22 SLC35A3 SLC43A2 SLC1A1 SLC2A9 SLC43A1 SLC1A2 RSC1A1 SLC3A1 SLC1A3 SLC2A2 SLC5A1 SLC1A4 SLC3A2 SLC6A3 SLC1A5 SLC7A11 SLC24A2 SLC44A5 SLC1A6 SLC24A3 SLC5A7 SLC6A20 SLC10A6 SLC7A10 SLC44A3 SLC1A7 SLC44A4 SLC7A1 SLC44A1 SLC7A3 SLC44A2 SLC25A29 SLC67A1 SLC38A3 SLC36A4 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 FGF21 SLC6A14 SLC6A12 SLC16A10 SLC6A6 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC35B3 SLC35B2 SLC5A5 ARL2 SLC35D2 SLC28A2 SLC29A1 SLC29A2 SLC4A1 SLC28A3 SLC47A2 SLC22A4 SLC14A1 APOD SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC35C1 SLC17A5 SLC25A5 SLC25A4 SLC25A6 SLC2A13 SLC5A11 SLC5A3 SLC35A1 SLC26A11 SLC35D1 SLC26A2 SLC34A3 SLC34A2 SLC34A1 SLC26A1 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 SLC5A2 SLCO1B1 SLCO1B3 SLC33A1 SLC6A13 SLC6A5 SLC26A4 SLC26A3 SLC6A11 SLC12A2 SLC22A2 SLC6A2 SLC12A3 SLC22A1 SLC22A12 SLC12A4 SLC2A10 SLC2A1 SLC12A5 SLC6A1 SLC12A1 SLC12A6 SLC6A4 SLC12A7 SLC29A3 SLC24A4 SLC32A1 SLC20A2 SLC35A2 SLC16A1 SLC24A5 SLC17A7 SLC4A7 SLCO1A2 SLC22A8 SLC25A10 SLC22A5 SLC24A1 RUNX1 SLC5A6 SLC6A7 SLC6A9 SLC17A6 PDZD11 AVP SLC15A1 CTNS SLC15A3 SLC15A4 SLC17A8 SLC8A1 SLC8A2 SLC2A3 SLC30A8 SLC30A5 SRI SLC22A3 SLC8A3 SLC4A2 SLC4A3 SLC4A5 SLC5A9 SLC60A2 SLC30A10 SLC5A4 ARL2BP SLC2A14 SLC2A11 SLC2A12 SLC39A10 SLC39A14 SLCO4A1 SLC29A4 SLC17A1 SLCO4C1 SLC28A1 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence TNRC6A TNRC6B UBA52 TP53 MDM2 SP1 MDM4 UBB UBC RPS27A RB1 CDKN2D CDKN2B CDKN2C CDKN2A E2F1 ETS1 E2F2 ETS2 E2F3 MAPK1 CDK6 MAPK3 TFDP1 ID1 TFDP2 ERF CDK4 MOV10 AGO3 AGO4 AGO1 TNRC6C REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus HIRA H2AX H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 PRM2 PRM1 H2BC9 NPM2 H2BC8 SRPK1 H1-8 H2BC5 H2BC11 H2BC3 H3-3B H2BC1 H4C9 METTL23 H2BC12L H2BC26 H2BC21 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation CALM1 PDE1C PDE1B PDE1A NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription DNM2 REST EGR2 TCF12 ATF2 JUNB CDK5 FOS NAB1 ATF1 NAB2 SH3GL3 ARC CDK5R1 TRIB1 TPH1 RRAD EGR3 EGR4 FOSL1 ID2 EP300 ID3 SGK1 LYL1 ID4 EGR1 F3 MEF2D VGF ASCL1 ELK1 CDK5R2 SRF CHD4 ID1 JUND FOSB C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT1 DAG1 POMT2 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways FURIN CALM1 RAB7A GBP1 KPNA1 UBA52 SFPQ B2M PGK1 RNF213 UBB SH3GL3 SH3KBP1 SRC UBC CTNND1 RPS27A STAM CBL CDH1 HGS CTNNB1 EPS15 STX1B CBLL1 SNAP25 MET STAM2 SYT2 SH3GL2 SV2C SH3GL1 SYT1 SV2B MRC1 SV2A VAMP1 VAMP2 STX1A HBEGF UBE2D2 UPK1A EPCAM MAPK1 ATP6V1H MAPK3 CD9 MAP2K1 MAP2K2 NOS2 ENO1 GSK3A DUSP16 EEF2 GBP6 CTSG KPNB1 RAB5A VPS33B HBB CORO1A HSP90AB1 CASP4 TLR2 PDCD6IP GUCY2C HBA2 CALM3 HSP90AA1 CALM2 MAP2K4 LTF GBP2 GBP4 NHERF4 TXNRD1 TRIM27 MAP2K7 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes CBFB RUNX1 CTSV SOCS3 SERPINB13 CTSL CTSK SOCS4 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations FKTN SLC35A4 CRPPA FKRP POMT1 B4GAT1 LARGE2 POMK MGAT5B DAG1 CHST10 RXYLT1 B3GALNT2 LARGE1 SLC35A1 POMGNT2 POMGNT1 POMT2 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome HDAC3 NCOR1 TBL1XR1 TBL1X CALM1 PRKACA HDAC1 SIN3A CAMK4 GPS2 NCOR2 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG PLA2G4B PLA2G3 PLA2G2A PLA2G4F CRLS1 LPCAT4 PLA2G10 PLA2R1 PLA2G1B LPCAT1 PLA2G5 PLA2G4A LPGAT1 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance PPP6C ACD H2AX PPP6R3 LIG1 PRIM2 PRIM1 POLA1 H3-3B POLA2 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP FEN1 ANKRD28 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 DAXX ATRX H2BC1 POLR2A GAR1 POLR2B CDK2 POLR2C H2AB1 POLR2D POLR2E POLR2F POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 POLR2J POLR2K POLR2L DSCC1 RUVBL2 SHQ1 PIF1 H2AC19 CHTF8 H2AC14 RFC5 CTC1 CHTF18 H2BC12L RFC3 TERT STN1 WRAP53 RFC4 TEN1 RFC1 RFC2 H2BC26 H2BC21 DNA2 H2BC17 DKC1 NHP2 BLM H2BC12 RTEL1 H2BC13 PCNA H2BC14 H2BC15 POLD3 POLD4 WRN H2BC11 RUVBL1 POLD1 NOP10 POLD2 H4C9 TINF2 RPA1 RPA2 H2AZ2 RPA3 H2AC20 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus NR4A1 FOXO6 AKT2 FOXO4 RPS6KB2 FOXO1 AKT3 AKT1 FOXO3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones ATF4 ATF6 CALR MBTPS2 MBTPS1 DDIT3 NFYA NFYB NFYC HSPA5 HSP90B1 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control UBE2D1 RCHY1 RPL4 NPLOC4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 UBE2D2 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 VCP RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X ANKZF1 RPL7A KLHDC10 RPLP2 TCF25 NEMF RPL13A ZNF598 RPS3A UBE2D3 PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PELO PSMD12 PSMD11 ELOB ABCE1 RPL26L1 PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ASCC2 ASCC3 LTN1 CUL2 UFD1 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense FURIN ACTG1 PIM1 GBP1 CASP1 SFN PGGT1B GBP3 ACTB GBP2 GBP4 GBP5 FNTA FNTB INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling GATA3 FN1 IL2RG JAK3 MMP9 CCL11 IL6 TYK2 JAK1 CXCL8 S1PR1 FOS COL1A2 CCL22 CDKN1A CCND1 ANXA1 STAT1 STAT3 BCL2 IL4 BCL2L1 IL13 HSPA8 LCN2 CEBPD SOCS5 BCL6 VEGFA HGF ICAM1 TGFB1 ZEB1 FGF2 ALOX5 HMOX1 PTGS2 ITGB1 OPRD1 MUC1 IL18 IL1A IL1B HSP90AA1 BIRC5 RORC VCAM1 IL6R IGHE NANOG TNF IL12B FASLG IL12A FOXO3 IL13RA2 LIF IL13RA1 TNFRSF1B FSCN1 NDN FCER2 MCL1 JUNB TWIST1 RHOU FOXO1 OSM SOCS3 BATF IL4R MMP1 POMC RORA ALOX15 SAA1 NOS2 ITGAM ITGB2 ITGAX TIMP1 F13A1 CD36 TP53 IRF4 OPRM1 MAOA SOX2 MYC IGHG4 IGHG1 AKT1 HSP90B1 IL10 PIM1 IL23R MMP3 LBP PIK3R1 HIF1A SOCS1 JAK2 POU2F1 VIM STAT6 IL17F IL17A MMP2 CCL2 LAMA5 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway ADCY3 GNAL OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 ANO2 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 CNGA2 OR10J3 OR10J5 CNGA4 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 LDB1 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 EBF1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 LHX2 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 GNG13 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 GNB1 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog CUL3 IFT52 GLI1 KIF7 GPR161 INTU TULP3 FUZ ADCY10 GPC5 IFT57 OFD1 DERL2 HHIP OS9 BOC IFT140 SPOP GAS1 CDON NUMB WDR35 VCP SEL1L ADAM17 WDR19 CSNK1A1 GSK3B HHAT DISP2 SCUBE2 ULK3 ERLEC1 PSMD8 DZIP1 SPOPL PSMD6 EVC2 PSMD7 IQCE PSMD2 EFCAB7 PSMD3 EVC PSMD1 DRC4 BTRC SKP1 PSMA5 PSMA6 ITCH PSMA3 PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PRKACB PSMD11 PSMD14 CDC73 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 IHH SHH P4HB SMURF2 ADCY9 SMO PRKAR1B SMURF1 PRKAR2B GLI3 GLI2 PRKACA DHH GRK2 ADCY4 ADCY3 IFT172 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR2A ADCY6 DYNC2H1 ADCY5 PRKAR1A RPGRIP1L IFT88 KIF3A TTC21B PTCH1 ARRB1 SUFU SYVN1 ARRB2 NOTUM IFT122 GNAS MKS1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection GSDMD MEFV CTSG NFKB2 RELA NT5E PYCARD HSP90AB1 NFKB1 HMOX1 C3 CASP1 NLRP3 IL18 PSTPIP1 IL1A IL1B P2RX7 P2RX4 TXNIP TXN C3AR1 SUGT1 ENTPD1 ENTPD5 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC PLA2G4B PLA2G4F PLA2G4E PLA2G4C GPCPD1 PLA2G15 PLBD1 PLA2G4A PLA2G4D PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL8 SSTR3 C5AR2 C5AR1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 C3 C5 CCR5 APP MC4R EDNRB EDN1 EDN3 MC3R POMC MC1R MC5R C3AR1 CX3CR1 CXCR4 CXCL12 MRGPRD PF4 PDYN AGTR2 FPR1 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 PNOC GPR37 CCL13 CCL11 CCL19 CCL17 CCL16 CCL25 CCL22 CCL21 CCL20 CCL28 CCL27 CXCL13 CXCL16 PSAP CXCL10 CXCL11 ECE1 ECE2 ANXA1 PRLHR CCL7 CCL5 CCL4 CCL3 CCL1 APLN GPR37L1 KEL NLN MC2R PENK PPY CCR10 CCR1 PPBP CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 GAL OPRD1 NPB CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR CCL3L3 PYY CXCL6 CXCL9 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 GRPR EDNRA PROK2 PROK1 UTS2R GPER1 NPFF TRHR UTS2B AGTR1 NPY5R SSTR1 FPR2 SSTR2 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R OPRL1 NMB XCR1 NMBR NMS NMU OXTR QRFP MLN AVPR1B NPY ACKR4 BRS3 AVPR2 ACKR3 OXT ACKR2 AVP ACKR1 CCKAR AVPR1A EDN2 TACR2 TACR3 TACR1 F2 SAA1 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R AGT MT-RNR2 F2RL1 F2RL2 F2RL3 PMCH GHSR OPRM1 F2R UTS2 NTS KNG1 MCHR2 TAC3 TAC1 NMUR2 NMUR1 MLNR TRH OPRK1 MCHR1 BDKRB2 BDKRB1 QRFPR XCL2 XCL1 CCK HCRTR2 HCRTR1 KISS1 SST CCL2 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions ITGA1 ITGB1 CHL1 NRP1 CNTN6 ANK1 HSPA8 ITGA10 ITGA2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases CEP57 CETN2 PLK1 CEP164 ACTR1A CCNB1 PCM1 CNTRL CDK1 CEP290 NINL CCNA2 CCNA1 RAB8A OFD1 CDKN1A TUBB HAUS4 HAUS3 FZR1 HAUS6 HAUS5 E2F1 TUBG1 E2F3 FBXL18 HMMR HAUS2 HAUS1 CDK2 CEP63 NEK2 SFI1 SDCCAG8 PPP2R1B PPP2R1A DCTN2 SSNA1 SGO1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E PHLDA1 CCNB2 NEDD1 ALMS1 CEP41 CEP43 XPO1 YWHAG EP300 DYNLL1 HSP90AA1 CKAP5 PSMD8 RBBP4 PSMD6 MAPRE1 PSMD7 PSMD2 PAFAH1B1 PSMD3 MYBL2 DYNC1I2 PSMD1 BTRC SKP1 PPP2CA PPP2CB FBXW11 AURKA PSMA5 PSMA6 PSMA3 CLASP1 YWHAE PSMA4 PSMA1 PSMA2 UBA52 PPP1R12A DYNC1H1 GTSE1 CDC25C PSMD12 FKBPL PSMD11 NDE1 CDC25A PSMD14 CDC25B PSMD13 CENPF CUL1 PSMA7 HJURP MIS18BP1 PSMB6 PSMB7 PSMB4 PSMB5 UBB TPX2 PSMB2 OPTN PSMB3 TUBGCP2 UBC PSMB1 RPS27A TUBGCP5 ADRM1 TUBGCP6 SEM1 TUBGCP3 CPAP TUBGCP4 RBX1 PSMC5 TUBG2 PSMC6 FBXL7 MZT2B PSMC3 MZT2A PSMC4 NME7 PSMC1 PPP1CB LIN54 MZT1 PSMC2 LIN52 PKMYT1 LIN37 LIN9 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B CCNH TICRR FOXM1 AKAP9 PRKAR2B PPP2R2A TUBA4A PRKACA TP53 CDK7 CCP110 MNAT1 CEP250 CDK5RAP2 CEP135 CEP131 CSNK1D TUBA1A HSP90AB1 CEP70 CEP72 CEP192 CEP76 CEP78 PPP2R3B PLK4 AJUBA ODF2 TUBB4B TUBB4A CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects KCNMB1 KCNMA1 PDE1B PDE2A PDE1A PRKG2 PDE5A KCNMB2 ITPR1 KCNMB3 KCNMB4 IRAG1 PDE9A PDE11A PDE10A DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations POMT1 DAG1 POMGNT1 POMT2 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases TNKS2 RNF146 GATA3 TGFBR1 SUDS3 USP17L4 USP17L5 USP17L8 RNF128 USP34 MDM2 MDM4 USP7 TADA2B USP2 WDR20 CCNA2 USP17L3 CCNA1 USP17L1 HGS VDAC3 STAM2 VDAC2 USP5 USP3 VDAC1 H2BC9 H2BC8 H2BC5 FKBP8 SKP2 H2BC3 H2BC1 USP10 DDB2 H2AC8 CDC20 H2AC6 H2AC7 USP17L30 MAT2B USP17L21 USP17L20 USP17L22 H2BC26 USP17L2 H2BC21 TOMM70 USP17L15 USP9X USP17L18 TOMM20 RCE1 USP17L17 USP17L19 USP17L10 TADA3 TAB1 H2BC17 USP17L12 USP17L11 H2BC12 USP17L13 H2BC13 H2BC14 H2BC15 TRAF2 H2BC11 RUVBL1 USP37 USP47 USP48 PSMD8 CFTR USP49 USP42 PSMD6 USP44 BIRC2 PSMD7 TRAF6 BIRC3 PSMD2 PSMD3 USP16 PSMD1 USP12 RIPK1 IKBKG USP19 KEAP1 MAP3K7 USP24 USP25 AXIN2 USP26 H2BC18 PSMA5 USP20 PSMA6 USP22 PSMA3 USP28 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 BECN1 PSMD13 RNF123 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC SIAH2 PSMB1 RPS27A IDE ADRM1 SEM1 NFKBIA TAF10 PSMC5 PSMC6 USP30 PSMC3 PSMC4 PSMC1 FOXO4 USP14 IL33 PSMC2 USP18 RHOT1 WDR48 POLB ADRB2 USP21 USP4 SMAD2 SMAD1 SMAD4 CYLD SMAD3 AR SMURF2 CLSPN IFIH1 SMAD7 PTRH2 TP53 RIGI H2AC17 H2AC12 AXIN1 CCP110 KAT2A H2AC1 USP15 H2AC19 H2AC25 H2AC14 H2AC21 ATXN7 PTEN MYC USP8 SNX3 ARRB1 ARRB2 USP11 MUL1 HIF1A USP33 UFD1 TRRAP H2AC20 OTUB1 USP13 TNKS ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCD2 ABCD3 ABCA3 ABCA10 PEX3 ABCG4 APOA1 ABCA6 ABCA2 ABCA5 ABCA9 ABCA7 PEX19 ABCD1 ABCG8 ABCA12 ABCG1 ABCG5 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes CCNK CCNT2 ELL CCNT1 GTF2B TBP NCBP1 NCBP2 GTF2A1 GTF2A2 TAF9 SUPT4H1 GTF2E1 GTF2E2 PCF11 TAF13 TAF11 CDK9 TAF8 TAF6 TAF5 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 PHAX CDK7 INTS1 INTS3 INTS2 SP1 SNAPC5 INTS5 SNAPC1 INTS4 SNAPC2 SRRT INTS7 SNAPC3 INTS6 SNAPC4 INTS9 ZNF143 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 NABP1 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 POU2F1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR RELA TRAF6 PSENEN ADAM17 PSEN2 PSEN1 APH1A NGFR NCSTN APH1B NFKB1 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response CASP3 CASP7 CYCS XIAP CASP9 DIABLO APAF1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LPL FURIN PCSK6 LMF2 PCSK5 LMF1 MBTPS1 LIPC CREB3L3 GPIHBP1 FGF21 APOA4 APOC2 APOA5 MBTPS2 ANGPTL8 ANGPTL3 ANGPTL4 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling CALM1 FOXO3 MMP9 FOS SRC S1PR3 PRMT1 NOS3 TGFA ELK1 CDKN1B EREG UHMK1 BTC EPGN CCND1 HBEGF GNGT1 NRAS MAPK1 GNGT2 HRAS MAPK3 EGF ESR1 CAV1 BCL2 AREG GNAT3 ESR2 PTK2 GNAI3 EGFR IGF1R ZDHHC7 GNG10 GNG3 ZDHHC21 GNAI1 GNG2 GNAI2 CAV2 AKT2 MMP7 GNG5 PRKCZ GNG4 AKT3 GNG7 GNG8 AKT1 XPO1 STRN SPHK1 PDPK1 MMP3 PIK3R3 SRF PIK3R2 PIK3CA PIK3R1 HSP90AA1 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 MMP2 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 TBK1 IRF3 UBA52 IRF7 TICAM1 TANK TRAF3 UBB IKBKE TLR3 OPTN UBC RPS27A MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing DDX46 DDX42 RBM17 SMNDC1 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 PHF5A SNRPN CHERP PTBP1 SNRPA1 DNAJC8 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 TCERG1 SRRM2 SNRPG SNRPC SRSF8 SNRPA SNRPE HTATSF1 CPSF4 RBM25 PPP1R10 SNRPF SNRNP70 PRPF40A SNRPB TUT1 PPP1R8 SRSF10 SRSF12 RBM39 HNRNPH1 HNRNPH2 RBM5 PABPN1 PAPOLG UBA52 NCBP1 NCBP2 UBB UBC RPS27A FIP1L1 PPP1CB HNRNPU EIF4A3 PPP1CA CASC3 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 POLR2A THOC6 POLR2B SRRM1 POLR2C DDX39A POLR2D DDX39B POLR2E SARNP POLR2F ZC3H11A POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 XRN2 FYTTD1 LUZP4 GTF2F1 RBM8A GTF2F2 POLDIP3 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP ALYREF SRRT UPF3B MAGOHB RNPS1 FUS HNRNPA1 HNRNPA3 TRA2B RBBP6 CCAR1 PCBP1 CPSF7 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC RBMX DHX9 HNRNPA2B1 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS NTRK3 HRAS NTF3 SOS1 NRAS INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production KPNB1 NOS2 KPNA1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines CXCL9 CXCL1 CXCL3 CCR5 CXCL2 CXCL5 CCL13 CCL11 CXCL8 CCL19 CCL17 CCL16 CCL25 CCL22 CCL21 CCL20 XCR1 CCL28 CCL27 CXCL13 CXCL16 ACKR4 ACKR3 ACKR2 CXCL10 CXCL11 CCL7 CCL5 CCL4 CCL3 CCL1 CCR10 CX3CR1 CCR1 PPBP CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CXCR4 CCR2 CXCL12 XCL2 XCL1 CXCR5 CXCR6 CXCR1 CXCR3 CXCR2 CCRL2 CCL3L3 PF4 CCL2 CXCL6 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis POMC HSD3B2 CGA HSD3B1 LHB SRD5A2 SRD5A1 CYP17A1 SRD5A3 HSD17B3 HSD17B12 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT1 DAG1 POMT2 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 VWF GP1BA ADAMTS13 GP9 GP1BB VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate AOX1 PDXK PNPO AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA DBT BCKDHB DLD REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase PPP6C ACD DKC1 PPP6R3 NHP2 RTEL1 RUVBL1 NOP10 RUVBL2 SHQ1 PIF1 TINF2 TERT WRAP53 TERF1 GAR1 TERF2 CDK2 CCNA2 CCNA1 POT1 TERF2IP ANKRD28 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) ATM H2AX HERC2 H2BC9 H3-4 PIAS4 H2BC8 H2BC5 H2BC3 H2BC1 BRCC3 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 NBN DCLRE1C RIF1 LIG4 H2BC12L PAXIP1 NHEJ1 XRCC4 TDP2 TDP1 H2BC26 UBE2V2 H2BC21 POLL UBE2N MDC1 H2BC17 H2BC12 POLM H2BC13 H2BC14 H2BC15 H2BC11 BARD1 H4C9 PRKDC RAD50 XRCC6 XRCC5 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy DUSP16 RAB7A GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation GATA4 TRIM33 TEAD2 TEAD4 YAP1 CDH1 CTNNB1 SNW1 NOG LFNG DLL1 TCF7 FOXC2 FGFR1 FOXC1 MAMLD1 OSR1 FGF2 FGF4 PAX2 BMP4 EP300 PAX8 LHX1 TFAP2A TFAP2B TFAP2C ZIC2 CREBBP LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TCF7L2 PSMD1 HES7 TCF7L1 TBPL2 MESP2 MSGN1 RIPPLY2 PAX7 DLL3 PSMA5 NOTO PSMA6 MSX1 NANOG PAX6 PSMA3 PSMA4 POU5F1 PSMA1 PSMA2 MAML2 MAML1 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 MYB PSMA7 FOXH1 ZIC1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 PAX3 SEM1 NOTCH1 PSMC5 DLX5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 IHH SHH SMAD2 SMAD4 SMAD3 KAT2B KAT2A SOX2 ZEB2 FGF8 SOX1 EOMES GATA6 CXCR4 GBX2 OTX2 TBXT SOX17 TBX6 POU3F1 GSC ZNF521 MIXL1 RBPJ WNT3A FOXA1 FOXF1 SNAI1 EPHA4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements H2AX ZNF610 ZNF324 SMARCB1 DNMT3L SPOCD1 C19orf84 TRIM28 ZNF320 ZNF264 H3-3B SMARCC1 SMARCC2 H3C8 ZNF317 ZNF30 ZNF257 H2AJ H3C15 ZNF708 H2BC9 H2BC8 H2BC5 ZNF547 H2BC3 SMARCA2 SMARCA4 H2BC1 MPHOSPH8 ACTL6A H2AB1 H2AC8 H2AC6 H2AC7 ZNF765 ZNF93 ZNF816 ZNF534 ZNF778 SMARCD3 ZNF224 MBD3 H2BC26 H2BC21 MTREX PIWIL4 GATAD2B GATAD2A H2BC17 ZNF519 H2BC12 H2BC13 H2BC14 H2BC15 SMARCD1 HDAC2 SMARCD2 H2BC11 ZNF454 CHD4 RBBP4 CHD3 ZCCHC8 RBBP7 SMARCE1 H2AZ2 RBM7 MTA2 TASOR PPHLN1 ZNF680 DNMT3A MORC2 ZNF354A MTA1 HDAC1 ZNF141 MTA3 ZNF382 UBE2I ACTB ZNF669 ZNF136 ZNF425 CBX5 SUMO2 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SS18L1 ZNF418 ARID1A ARID1B H2AC19 H2AC14 H2BC12L ZNF649 ATF7IP SETDB1 EHMT2 EHMT1 H4C9 ZNF33A ZNF331 H2AC20 ZNF28 ZNF273 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins ETV6 STAT5A STAT5B PIM1 GAB2 NOX4 ZMYM2 SOS1 CDKN1A PIK3R1 PIK3CA NRAS GOLGB1 HRAS SPTBN1 MYO18A TRIP11 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction DMD KCNK6 KCNK7 KCNK1 PAK1 PAK2 PXN NPPA NPR1 NPR2 NPPC CORIN TNNI1 TNNI2 MYBPC3 TMOD1 MYBPC1 MYBPC2 ACTN3 CALM1 TMOD4 TNNC1 TMOD2 TNNC2 NEB MYL4 MYH3 DES MYL1 TNNT1 MYL2 TNNT2 MYL3 TNNT3 MYH8 TCAP MYH6 NKX2-5 ANXA2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 KAT2B ACTN2 TTN KCNH2 KCNK10 KCNK13 TMOD3 KCNK16 KCNK17 KCNK18 KCNQ1 HIPK1 PDE5A HIPK2 VIM KCNK9 MYL9 KCND1 KCND2 SCN11A KCND3 GATA4 SCN9A SCN1B SCN1A SCN10A KCNA5 SCN8A KCNJ14 SCN3B SCN3A KCNK2 KCNK3 KCNK4 TRIM72 GUCY1B2 GUCY1B1 ITGB5 DYSF LMOD1 MYL6B SCN2A CACNA1H MYL12A SCN2B MYLK MYL12B CACNA1G CACNA1I SCN5A CALD1 ANXA6 MYL10 MYH11 GUCY1A2 GUCY1A1 ANXA1 CAV3 TPM4 SCN4A TPM3 SCN4B MYL11 TPM2 SCN7A TPM1 SORBS1 SORBS3 MYL5 MYL6 MYL7 CACNA2D2 CACNA1C CACNG6 FGF14 RANGRF FGF13 FGF12 FGF11 CACNB1 CACNB2 CACNG8 KCNJ2 CACNG4 KCNJ4 ITGA1 KCNJ12 KCNIP3 ALDH2 KCNK5 KCNK12 KCNK15 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 AKAP9 SLC8A1 RYR3 SLC8A2 SLN NOS1 CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 TRDN ASPH STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A MME ATP1A4 ITPR1 ATP1A3 CES1 ITPR2 ATP1A2 ITPR3 ATP1A1 SRI PLN TNNI3 CACNG7 CAMK2G KCNJ11 DMPK ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 FXYD4 FXYD3 FXYD2 FXYD1 KCNIP1 FKBP1B KCNIP2 FXYD7 KCNIP4 FXYD6 WWTR1 TRPC1 TLN1 VCL TBX5 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 BCKDHA DBT BCKDHB DLD COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6A TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle ARHGAP12 RAB7A VAMP3 FARP1 DIAPH2 ARHGAP39 ARHGAP21 LMNB1 SRGAP2 MTMR1 POTEE MCAM SOWAHC FAM169A ADD3 VANGL1 ARHGAP32 DIAPH3 ESYT1 MYO9B SNAP23 BAIAP2L2 SYDE1 PIK3R2 PIK3R1 BAIAP2L1 STEAP3 AKAP12 ARHGAP1 ACTN1 SLC4A7 SENP1 ARHGAP5 RHOF ACTB CAPZB TMPO DIAPH1 CAV1 BASP1 DEPDC1B TOR1AIP1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis CAST YWHAE APP JUN CDKN2A FASLG SOD2 TP53 CDC25C C1QBP FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists DKK1 DKK2 DKK4 SFRP1 SFRP2 WNT3A SOST KREMEN1 KREMEN2 LRP5 LRP6 WNT5A WIF1 WNT9A WNT4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import TIMM23 TIMM22 TIMM21 NDUFB8 TOMM40 SLC25A12 TAFAZZIN TIMM9 TIMM13 SLC25A13 TIMM10 TIMM8B TIMM8A IDH3G SLC25A4 GFER SLC25A6 ATP5MC1 TOMM7 TOMM5 TOMM6 ATP5F1A CHCHD3 SAMM50 ATP5F1B HSPA9 MTX1 PMPCB MTX2 PMPCA VDAC1 COQ2 GRPEL1 OTC HSPD1 TOMM70 TOMM20 TOMM22 CHCHD4 CHCHD5 CHCHD2 CHCHD7 CMC4 CMC2 PAM16 COX19 COX17 TIMM50 PITRM1 LDHD GRPEL2 HSCB DNAJC19 BCS1L COA4 CHCHD10 TIMM44 CS TIMM10B ACO2 TIMM17A TIMM17B CYC1 FXN COA6 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport SERPINA1 HSPH1 PPP6C TFG PPP6R1 PRKAG1 PPP6R3 PRKAG2 TMED2 CTSC CD3G TRAPPC2L LMAN1L F5 F8 CD3D PRKAG3 SBF2 TRAPPC6A TBC1D20 RAC1 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TFRC TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 FTH1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 FTL SEC23IP CNIH1 KIF20A KLC1 CNIH2 KLC4 CNIH3 KLC3 FOLR1 KLC2 BET1 NEDD8 KIF11 KIF15 KIF23 EGF KIF22 AREG KIF26A TF COPS5 SCARB2 ITSN2 AGFG1 GAPVD1 BIN1 AMPH GRK3 CLTCL1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A YWHAG SYNJ2 TOR1B SNAP23 SYT9 SYT8 SNAP91 DAB2 AAK1 IL7R COL3A1 PICALM STON1 STON2 COL4A2 PIK3C2A COL4A1 SLC2A8 SGIP1 COL7A1 EPS15L1 PRKAA2 ARFGAP1 OCRL EPN1 EPN2 GAK CTTN ARF6 LRP2 FCHO1 FCHO2 RACGAP1 REPS2 UBQLN1 UBQLN2 HIP1R SNX18 NECAP2 NECAP1 CD4 SYT11 TRIP10 AP2A1 AP2A2 LDLRAP1 AP2M1 MAP1LC3B SPARC STXBP3 AP2S1 RAB27B LDLR CHRM2 GJA1 AP2B1 GJB2 ALB ADRB2 MAN2A1 MYO5A ARPC1A WASL HYOU1 GNS CD163 MYH9 ARFGAP2 DVL2 KDELR1 STAB2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 MYO1C CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SFN SNX5 TBC1D8B SNAPIN SORT1 DTNBP1 PUM1 TPD52L1 GOLGB1 YIPF6 ACBD3 COL1A1 SYNJ1 ALS2 COL1A2 GJC1 GJD2 MAN1A2 MAN1C1 GJA10 MAN1A1 CLINT1 DENND1C DENND1B GDI1 DENND5B DENND1A KDELR3 GDI2 RINL TRAPPC12 DCTN1 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 NSF DENND6A RIN1 RIN2 DENND3 RAB21 ALS2CL CHML GRIA1 ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB39B TRAPPC8 RAB12 EGFR RAB18 VPS45 RAB3GAP2 RAB3GAP1 MON1A MON1B COLEC12 MSR1 SCARA5 MARCO SCGB3A2 CALR FNBP1L FNBP1 CLTC CLTA HSP90AA1 UBA52 DCTN6 DCTN5 DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 UBB OPTN UBC RPS27A SAA1 AP3B1 GALNT1 CD36 RAB27A KIFAP3 CSNK1D HIP1 KIF3B KIF3A TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 KIF3C VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 RAB3IP CHMP5 ARF4 AP1G1 ACTR1A AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 GALNT2 SH3GL3 SH3KBP1 STAM CBL RAB8A HGS EPS15 EXOC8 TGFA STAM2 SH3GL2 EXOC7 SH3GL1 RALA YWHAB IGHV3-23 APOE IGLV IGLV2-8 IGKV1-16 AGPAT3 IGKV1-17 IGKV1-12 SBF1 IGHV3-7 SCARF1 IGHV3-9 V2-11 IGHV3-30 EXOC4 V3-4 EXOC3 V3-3 EXOC6 V2-17 V3-2 IGHV3-33 EXOC5 V2-15 IGKV1D-39 EXOC2 V2-19 IGKV1D-33 EXOC1 IGKV2D-28 IGKV4-1 IGHV7-81 DCTN2 DCTN3 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 GBF1 IGLV6-57 IGLV2-14 RAB11A IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 HBB TRIP11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 APOB IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 C2CD5 IGHV ITSN1 SLC2A4 IGKV2-29 RALGAPA2 IGKV2-28 IGLC3 TBC1D1 RALGAPB APOA1 IGLC1 HBA2 IGLC2 TBC1D4 V1-9 ASPSCR1 V5-4 RAB10 V1-7 RAB14 GJB1 V5-1 RAB13 USP6NL V1-5 SCOC V1-3 CFTR IGKV3D-20 SYS1 V5-6 GCC2 GCC1 RABEPK YWHAQ IGLV3-19 RAB43 GOLGA4 IGKV2-30 IGHV2-70 GOLGA1 ARFGAP3 IGHV2-5 ARFIP2 NAA30 IGLV3-1 IGHV3-48 COG8 IGLV3-25 COG7 IGLV3-27 COG6 COG5 IGKC IGLV3-21 COG4 INS LRP1 COG3 CALM1 IGKV1-39 GJA3 COG2 RAB7A IGKV1-33 GJA5 V4-6 COG1 YWHAE GJA4 VAMP3 IGHV3-53 APP NAA35 GJA9 V4-2 NAA38 GJA8 VAMP4 IGLC7 GJC2 V4-1 NAPA GJB4 NAPB IGKV5-2 GJB3 TMF1 IGKV1-5 GJB6 STX16 IGLC6 GJB5 RHOBTB3 GJB7 LMAN1 ARL1 GJD4 STX5 GOLGA2 NAPG GJD3 YKT6 STX10 TGOLN2 ARFRP1 VPS51 VPS53 PRDX1 VPS52 VTI1A YWHAH STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B RABGAP1 YWHAZ GABARAP GGA2 RABGEF1 GGA1 GGA3 TBC1D13 TBC1D10C S100A9 TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B WNT5A TBC1D2 PLIN3 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B PLA2G6 CHM ARF5 ARCN1 RAB5B RAB5C RAB5A CD55 GPS1 KDELR2 MYO6 FZD4 MIA2 CD5L COPS4 SSC5D COPS2 GOSR1 ANK2 ANK3 ANK1 TSC2 TSC1 SPTBN4 SPTBN5 SPTA1 COPZ2 SPTBN1 COPZ1 SPTBN2 KIF4B KIF4A RAB41 SYT2 SYT1 EREG SPTAN1 SPTB BTC VAMP2 RAB30 EPGN DNM1 HBEGF RAB36 DNM3 ARF1 CTSZ AP4E1 CLTB BET1L AP4M1 AP1G2 BLOC1S1 SEC23A CLVS2 AP4S1 CLVS1 SAR1B TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 SEC24B DYNC1LI1 SEC24A DYNC1LI2 ZW10 SEC24D TMED3 SEC24C TMED7 SLC18A3 TMED9 RAB3A KIF18A HMGB1 SEC13 COPG2 COPG1 COPB2 COPA DYNLL1 COPB1 MAN2A2 TMEM115 DYNLL2 CHMP4C COPE KIF2A CHMP4B CHMP3 CHMP4A KIF2C CUX1 CHMP6 KIF2B CHMP7 PAFAH1B1 DYNC1I2 COPS7B COPS7A COPS3 COPS6 CHMP2B DYNC1I1 CHMP2A COPS8 DYNC1H1 CENPE AGTR1 LNPEP AVPR2 AVP TJP1 STX4 GOLIM4 TACR1 CAPZB CYTH3 CYTH2 GOLGA5 CYTH4 SNAP29 CYTH1 ALPP CAPZA1 CAPZA2 STAB1 GRK2 HP KIF5C PLA2G4A HPR HPX KIF5B IGHA1 KIF5A IGHA2 AMBP JCHAIN KIF28P KIF12 USE1 AKT2 KIF19 KIF13B AKT3 KIF1C KIF21A AKT1 KIF1B KIF21B PRKAB2 HSP90B1 KIF1A MIA3 KIF25 KIF6 PRKAB1 KIF27 RINT1 MASP1 KIF9 KIFC2 KIF16B KIFC1 KIF20B NBAS COLEC11 ARRB1 STX18 BNIP1 ARRB2 SURF4 KIF18B KIF26B APOL1 ARF3 MCFD2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex MCM6 CDC6 MCM2 PRIM2 PRIM1 POLA1 POLE POLA2 ORC5 ORC4 ORC6 ORC1 MCM8 GMNN ORC3 ORC2 CDT1 MCM10 DBF4 RPA4 CDC7 RPA1 RPA2 CDC45 POLE4 CDK2 MCM7 RPA3 POLE2 MCM3 POLE3 MCM4 MCM5 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine CTH CBS DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 GCK NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 GCKR AAAS SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LRP5 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade VTN CD59 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 CD81 V3-3 C4BPA V2-17 C4BPB V3-2 CLU IGHV3-33 V2-15 SERPING1 IGKV1D-39 CPB2 V2-19 CFH IGKV1D-33 C5AR2 C5AR1 IGKV2D-28 CFI IGKV4-1 C6 IGHV7-81 C7 C9 CD19 V1-11 C8B IGKV2D-30 C8A V1-16 C8G V1-13 CR2 IGHV4-59 CD46 IGHV1-69 CPN2 CPN1 CFHR2 IGLV2-11 CFHR1 IGLV1-40 CFHR4 IGLV1-47 CFHR3 IGLV6-57 CFHR5 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CR1 C3 C4A IGKV3-20 C5 IGHV4-34 C4B_2 IGHV1-2 CFB IGHV1-46 C2 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 ELANE IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PROS1 F2 C3AR1 IGHG3 IGHG4 IGHG1 IGHG2 CD55 FCN1 FCN2 FCN3 MASP1 CFD MBL2 CRP C1QB C1QA COLEC11 COLEC10 C1S C1R GZMM C1QC DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation MCM6 MCM2 LIG1 PRIM2 PRIM1 POLA1 POLA2 RFC5 RFC3 RFC4 MCM8 RFC1 RFC2 FEN1 DNA2 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 GINS1 RPA2 GINS2 CDC45 MCM7 GINS3 GINS4 RPA3 MCM3 MCM4 MCM5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway IFIH1 RNF135 EP300 TBK1 TRIM25 IRF3 SIKE1 MAVS IFNB1 TRIM4 CREBBP RIGI IRF7 TRAF3 IKBKE DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases PPP2CA PPP2CB PPP2R1B PPP2R1A MAPKAPK2 JUN ATF2 RPS6KA1 FOS ATF1 MEF2A DUSP4 DUSP3 RPS6KA5 MAPK9 VRK3 MAPK8 DUSP6 MAPK7 DUSP7 ELK1 PPP2R5D MAPK10 MEF2C RPS6KA3 RPS6KA2 MAPK1 MAPK3 MAPK14 MAPK11 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body CD320 LMBRD1 ABCC1 LRP2 TCN2 LDLRAP1 ABCD4 TCN1 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses IDUA IDS HGSNAT SGSH GUSB GALNS ARSB GNS GLB1 NAGLU HYAL1 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol CYP8B1 NCOA1 BAAT NCOA2 AKR1C3 ACOX2 HSD3B7 SLC27A5 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 ABCB11 CYP7A1 CYP27A1 ACOT8 HSD17B4 AMACR RXRA SLC27A2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction STRA6 RDH12 OPN1LW LRAT RLBP1 OPN1MW TTR NAPEPLD ABCA4 RBP4 RDH5 OPN1SW RBP1 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer SOS1 EREG PIK3R1 BTC PIK3CA SHC1 NRG2 HBEGF NRG3 EGFR NRG4 NRAS HSP90AA1 GAB1 CDC37 HRAS ERBIN PLCG1 EGF PTPN12 ERBB2 NRG1 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism RIDA SDS SDSL TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex CDC6 MAX TOP2A LIN54 PCNA LIN52 LIN37 HDAC1 LIN9 CDC25A E2F1 E2F4 E2F5 RBL2 RBL1 TFDP1 RBBP4 TFDP2 MYC ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway GNAI3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNAT3 ADCY9 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 UBE2D1 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 RCHY1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 APEH MRPS6 MRPS5 MRPL43 MRPL44 TUFM MRPS18C MRPL52 OXA1L MRPL53 UBE2D2 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 EEF1B2 MRPS30 EEF1G MRPL15 EEF1A1 MRPL12 EEF1D MRPL57 EEF1A2 MRPL13 EIF5 EEF1A1P5 MRPL54 EEF2 EIF5B MRPL10 MRPL11 MRPL55 VCP MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 PPA1 DDOST ANKZF1 KLHDC10 TCF25 NEMF ZNF598 MT-CYB EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 ELOB ELOC QARS1 TARS1 AARS1 HARS1 FARSA RARS1 FARSB MALSU1 MIEF1 MARS1 MTFMT YARS1 NARS1 CARS1 RBX1 VARS1 MTIF2 DARS1 MTIF3 WARS1 LARS1 MTRFR SARS1 MTRES1 EEF1E1 KARS1 IARS1 AIMP1 AIMP2 EPRS1 GSPT2 GSPT1 PABPC1 CUL2 MT-CO1 NDUFAB1 ETF1 UFD1 MT-CO2 MT-CO3 EIF4EBP1 EIF4E EIF4B EIF4G1 RPL4 NPLOC4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 SSR1 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 SRPRA SRPRB RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 HEMK2 RPS7 RPS8 RPL23 SEC11A RPS5 SEC11C RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 TRMT112 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RARS2 AARS2 MARS2 PARS2 RPS21 SPCS3 RPS24 SPCS2 DARS2 HARS2 RPS23 SPCS1 RPLP1 YARS2 FARS2 RPLP0 WARS2 GARS1 LARS2 RPS4X RPL7A SARS2 PPA2 RPLP2 NARS2 TARS2 RPL13A IARS2 VARS2 RPS3A UBE2D3 CARS2 PSMD8 EARS2 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A MT-ND6 PSMA2 RPL23A MT-ND4L UBA52 RPL22L1 MT-ND4 FAU MT-ND5 PELO PSMD12 MT-ND2 PSMD11 ABCE1 RPL26L1 MT-ND3 PSMD14 MT-ND1 PSMD13 MTRF1 GFM2 MRRF PSMA7 MTRF1L PSMB6 PSMB7 MT-ATP6 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M SEC61A2 EIF3K MT-ATP8 EIF3L SEC61A1 EIF3I SEC61G EIF3J SEC61B EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B ASCC2 ASCC3 LTN1 SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RPN2 RPN1 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress RAD1 MCM6 CDC6 MCM2 RAD9B ATR RAD9A CDC25C CDC25A CHEK1 ORC5 RFC5 ORC4 RFC3 ORC6 ORC1 RFC4 MCM8 ORC3 ORC2 RFC2 HUS1 MCM10 DBF4 CDC7 ATRIP RPA1 RPA2 CDC45 CDK2 MCM7 RPA3 MCM3 CLSPN MCM4 RAD17 MCM5 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex PPP1CC CSNK2B CRY2 CRY1 PER2 PER1 PPP1CB PER3 PPP1CA CSNK1E CDK5 CSNK1D CSNK2A1 CSNK2A2 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF RASA1 RAC1 FLT4 VAV1 CTNND1 SHB CTNNB1 SH2D2A PAK1 NOS3 NRP2 RICTOR PAK3 SHC2 PAK2 NRAS HRAS PLCG1 CDH5 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 CRK THEM4 FLT1 VEGFA HSPB1 PXN PRR5 PRKCZ RHOA PIK3CB MLST8 NCKAP1 NCF1 NCF2 NCF4 PDPK1 BRK1 CYFIP1 PIK3CA CYBB HSP90AA1 JUP CYBA CDC42 FYN NCKAP1L WASF1 MTOR WASF2 PRKCB ELMO2 DOCK1 BAIAP2 CALM1 ABI2 PGF ABI1 PRKACG PRKACB KDR ELMO1 AXL PTK2B CYFIP2 CAV1 AHCYL1 VEGFB VEGFC VEGFD PRKACA VAV3 ITGAV PTK2 PRKCD PRKCA VAV2 ITPR1 ITPR2 AKT2 NRP1 ITPR3 AKT3 AKT1 ROCK1 ROCK2 AAMP SPHK1 BCAR1 TRIB3 ITGB3 MAPKAP1 PIK3R2 PIK3R1 NCK2 CTNNA1 NCK1 WASF3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation SNAP25 ABAT SYT1 SLC6A13 VAMP2 SLC6A12 CPLX1 STX1A SLC6A11 DNAJC5 GAD1 GAD2 SLC6A1 SLC32A1 ALDH5A1 RAB3A RIMS1 HSPA8 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants FLT3 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex HDAC3 NCOR1 TBL1XR1 TBL1X GPS2 NCOR2 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters AHCYL2 SLC4A1 SLC4A2 SLC4A7 SLC4A10 SLC4A3 SLC4A8 SLC4A5 SLC4A9 SLC4A4 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta UBE2L6 CHUK HERC5 ITCH UBE2K APP UBA52 UBE2D1 RELA TANK TRAF3 UBB IKBKE NKIRAS1 NKIRAS2 UBC RPS27A NFKB1 NFKBIA ATG12 DHX58 NLRX1 ATG5 RNF125 TRIM4 RNF216 IFNB1 NFKBIB NLRC5 UBE2D2 CASP10 AGER S100A12 TNFAIP3 MAP3K1 S100B SAA1 TKFC IFNA5 CYLD IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TBK1 TRIM25 IRF3 IFNA21 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI NFKB2 PIN1 TAX1BP1 HSP90AB1 ISG15 TOMM70 HMGB1 UBA7 CASP8 EP300 PCBP2 CREBBP TRAF2 OTUD5 HSP90AA1 IRF7 UBE2D3 IKBKB TRAF6 IKBKG RIPK1 FADD FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation RAC1 FOS VAV1 MAPK9 MAPK8 PAK1 PAK2 MAPK10 IGHV3-23 IGLV NRAS IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 HRAS IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 GRAP2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 JUN V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAP3K1 PLCG2 VAV3 SYK VAV2 LYN MAP2K4 LCP2 MAP2K7 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins POM121C SUMO2 NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 PIAS4 UBE2I TOPORS NUP205 POM121 NUP107 NUP188 SUMO1 AAAS ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress DIS3 PARN EXOSC7 EXOSC6 NFYA EXOSC5 NFYB EXOSC4 NFYC EXOSC9 KHSRP IGFBP1 EXOSC8 EXOSC3 EXOSC2 CXCL8 EXOSC1 HERPUD1 CEBPB DCP2 ATF4 ATF6 ATF3 CEBPG ASNS DDIT3 CCL2 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) H2AX H3-3B TEAD4 KDM6B H3C8 H2AJ EIF4E EIF4B YAP1 HIRA EIF4G1 H3C15 EIF4A2 EIF4A1 H2BC9 H2BC8 H2BC5 EIF4A3 H2BC3 KDM5A UHRF1 KDM6A H2BC1 STPG4 AICDA CNOT6L METTL23 DPPA3 TET3 H2AB1 H2AC8 H2AC6 H2AC7 CNOT4 CNOT6 KDM5B CNOT7 TNKS1BP1 CNOT1 TP53 CNOT2 CNOT3 SRPK1 CNOT8 CNOT9 H2AC19 H2AC14 H2BC12L TUT7 PABPC1 KDM4E TUT4 H2BC26 BTG4 H2BC21 TPRX1 DUX4 ZFP36L2 PABPN1L LEUTX TPRXL EP300 DPPA4 DICER1 TPRX2 H2BC17 DPPA2 ZSCAN4 DUXA DIS3L2 H2BC12 DUXB H2BC13 H2BC14 H2BC15 PRM2 PAIP1 PRM1 CREBBP NPM2 CNOT10 H1-8 H2BC11 CNOT11 H4C9 H2AZ2 H2AC20 PABPN1 AGO2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling UBE2L6 IFIH1 HERC5 RNF135 TBK1 TRIM25 ITCH IRF3 UBE2K MAVS UBA52 UBE2D1 RIGI PIN1 TRAF3 UBB IKBKE TAX1BP1 UBC ISG15 RPS27A UBA7 ATG12 NLRX1 ATG5 RNF125 RNF216 TRIM4 NLRC5 PCBP2 UBE2D2 OTUD5 TNFAIP3 UBE2D3 CYLD TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases CRADD ATM CASP1 TP73 PIDD1 TP63 TP53 CASP6 CASP10 CASP2 APAF1 NLRC4 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT6A CCT8 TCP1 CCT7 ACTB CCT5 CCT4 CCT6B CCT3 CCT2 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 NUP37 NUP107 GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 NUP160 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE NUP85 GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 TGS1 SNUPN SEC13 NUP133 NUP205 POM121 NUP188 AAAS RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions UBE2L6 HERC5 IFNAR1 CCNC UBA52 ELOB GPC1 BECN1 ELOC TYK2 GPC3 JAK1 GPC2 GPC5 GPC4 STAT2 GPC6 MED9 UBB CD14 MAP1B MED8 UBC AGRN MED4 MED6 RPS27A CDK19 MED7 RBX1 MED16 MED15 MED17 MED12 MED14 IFNB1 MED13 MED30 MED10 MED31 CLEC4M IFNA5 MED27 IFNA4 MED26 IFNA7 IFNA6 IFNA1 MED23 IFNA2 MED25 IFNA8 MED24 IFIH1 MED20 TRIM25 IRF3 IFNA21 CDK8 IFNA14 IFNA16 IFNA17 MAVS MED19 IFNA10 MED18 RIGI MED11 HSPG2 MED29 CX3CR1 MED28 MED22 MED21 SDC4 SDC2 SDC3 LY96 TLR7 TLR3 EIF2AK2 ISG15 CUL5 CD209 EP300 TLR6 SDC1 TLR2 MED1 H2BC15 CREBBP MED13L OAS2 ARIH1 TLR4 BCAP31 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2I PTBP1 POLR2J POLR2K POLR2L GTF2F1 GTF2F2 NCBP1 NCBP2 HNRNPM HNRNPA1 HNRNPH1 HNRNPF TIAL1 TIA1 RBFOX2 ESRP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ESRP1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex BCL7A BCL7C BCL7B DPF2 SS18 SMARCB1 SMARCD1 SMARCD2 BCL11B PHF10 ARID1A ACTB SMARCA4 SMARCC1 SMARCD3 SMARCC2 ACTL6A SMARCE1 BCL11A FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SMARCB1 SS18L1 SMARCD1 ARID1A SMARCA2 ARID1B ACTB SMARCA4 SMARCC1 ACTL6A SMARCE1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP TTF1 UBTF POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H TAF1D POLR1C TAF1B TAF1C TAF1A POLR1D CAVIN1 CCNH POLR2E POLR2F POLR2H SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 CHST10 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT GALNTL5 SLC35A1 GALNTL6 B3GNT3 LARGE2 POMT2 SEMA5A GALNT12 SPON2 SEMA5B SPON1 FKTN THSD7B SLC35A4 POMT1 FKRP ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 MUC13 THSD7A MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 POMGNT1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 B4GALT6 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 B4GALT5 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 MUC16 MUC17 C1GALT1 MUC19 SSPOP POMGNT2 MUC5B MUC20 MUC21 POMK MGAT5B B3GALNT2 ST6GALNAC2 ST3GAL4 CRPPA ST3GAL1 GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 DAG1 ST6GALNAC3 ST6GALNAC4 POFUT4 POFUT2 POFUT3 MMRN1 THBS1 B4GAT1 RXYLT1 EMID1 B3GNT7 B3GNT4 MMRN2 B3GNT2 GALNT11 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS HRAS NTF4 SOS1 NTRK2 NRAS BDNF CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation NARS1 CARS1 VARS1 DARS1 WARS1 LARS1 SARS1 EEF1E1 KARS1 GARS1 IARS1 AIMP1 AIMP2 QARS1 EPRS1 PPA1 TARS1 AARS1 HARS1 RARS1 FARSA FARSB MARS1 YARS1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation SERPINA1 CTSC MAGT1 HSPA6 ARSA RAC1 TCIRG1 FTH1 CD59 TRAPPC1 ATP6V0C FTL TCN1 CAND1 ACTR1B CTSH ATP6V1D HMOX2 ATP6V0A1 EEF1A1 LCN2 C5AR1 EEF2 ADAM10 VCP CHRNB4 NAPRT PDXK STK10 ALOX5 C3 SNAP23 DDOST SERPINB6 PLAU STOM MGAM CYBB JUP CYBA DIAPH1 CHIT1 NCKAP1L CKAP4 PTPN6 FCER1G AP2A2 GPR84 TOLLIP TNFRSF1B SLC2A5 NPC2 ACAA1 PSEN1 NCSTN SLC27A2 BIN2 A1BG MMP25 CEACAM6 SERPINA3 ORM1 CEACAM8 ORM2 QSOX1 AHSG IDH1 ADAM8 CD63 C3AR1 ARHGAP9 GOLGA7 MMP8 CTSG GNS PECAM1 PYCARD LRRC7 CCT2 DERA OLR1 CEACAM3 CDA PYGB CD58 SIRPA PYGL ARPC5 FAF2 BST2 SELL RHOF ACTR2 MANBA FGR CCT8 GAA PGAM1 TUBB4B FCGR2A ARHGAP45 ALDOC ALDOA PPIE FRK CD44 DDX3X SIRPB1 DYNLT1 MMP9 DBNL AGL MOSPD2 GYG1 SIGLEC9 HVCN1 GDI2 LILRA3 HSPA1B LAIR1 CLEC5A RAB31 LILRB2 LILRB3 GSN SIGLEC5 OSCAR MAN2B1 HPSE RAB18 B4GALT1 KPNB1 HLA-H HK3 HLA-C PGM2 PGM1 TLR2 HSP90AA1 DNAJC3 LTF PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 GALNS PFKL PSMA2 ALAD PSMD12 PSMD11 HSPA1A PSMD14 PSMD13 HLA-B TICAM2 PSMB7 ACTR10 PAFAH1B2 CD14 PSMB1 NFKB1 VNN1 PSMC3 PSMC2 PTPRC CD33 SLC15A4 CD300A S100A12 AMPD3 NDUFC2 APRT PNP CD177 TYROBP CD36 RAB27A ATP8A1 CLEC4C ITGAL CLEC4D ATP11B ATP11A SRP14 APAF1 PRDX6 GSTP1 TRPM2 MIF CNN2 ATP8B4 CYB5R3 SLCO4C1 ANO6 LGALS3 B2M AP1M1 CEP290 APEH TUBB LPCAT1 SLC11A1 NRAS AGPAT2 RAP1A MAPK1 P2RX1 MAPK14 DSC1 PKM ARG1 PLAC8 HBB CEACAM1 RHOA ASAH1 CYFIP1 RAB10 RAB14 LAMP2 ILF2 STBD1 RHOG PPIA CAT RETN DOCK2 RAB7A PLD1 IQGAP2 PRTN3 HGSNAT VAPA AOC1 CAPN1 RAB6A IST1 IGF2R SLC44A2 RAB9B TBC1D10C S100A9 S100A8 DGAT1 FRMPD3 GMFG ABCA13 ADGRE5 PGLYRP1 FUCA1 FABP5 NHLRC3 MCEMP1 ADGRE3 RNASE3 CDK13 SCAMP1 RNASE2 ITGAM UNC13D ITGB2 FLG2 PADI2 GPI CRACR2A PRDX4 S100A11 AZU1 PA2G4 ITGAX HRNR PIGR SERPINB3 CD47 SERPINB1 NFAM1 TMT1A ITGAV ANXA2 TMC6 PLEKHO2 SERPINB10 GRN NME2 SERPINB12 AGA ERP44 LRG1 RAB5B IMPDH1 YPEL5 RAB5C GHDC TMEM179B IMPDH2 EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A CAP1 S100A7 FCGR3B BRI3 PTPRB HSP90AB1 NIT2 ROCK1 FCAR CD55 GM2A ACP3 RNASET2 TMBIM1 CANT1 FGL2 PRCP CPPED1 BST1 MNDA FOLR3 VPS35L CALML5 C6orf120 KRT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 VAT1 PTPRN2 CTSD SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 CYSTM1 PTPRJ GLIPR1 CAMP CD53 FPR1 RAP2C RAP2B DNASE1L1 CSTB PGRMC1 CREG1 KCNAB2 ORMDL3 GCA PTGES2 SVIP QPCT CD68 MPO COTL1 ENPP4 OSTF1 CD93 IRAG2 ATAD3B DOK3 ADGRG3 HEXB NEU1 DPP7 ALDH3B1 GGH CAB39 DNAJC13 TARM1 CTSA DEGS1 MS4A3 TNFAIP6 CRISP3 HEBP2 LAMTOR2 CHI3L1 GLB1 LAMTOR1 CLEC12A MVP LAMTOR3 TMEM30A CMTM6 RAB3D PDAP1 RAB44 S100P GUSB PTX3 SNAP25 ARSB GLA SPTAN1 PSAP RAB37 RAB4B CTSZ COMMD9 NFASC COMMD3 TXNDC5 RAB24 HSPA8 VAMP8 DYNC1LI1 MLEC PPBP DSN1 RAB3A HMGB1 CR1 CFP CXCR1 DYNLL1 DNAJC5 COPB1 CXCR2 PLAUR SDCBP ELANE GSDMD MGST1 CXCL1 DYNC1H1 ARMC8 FPR2 CPNE1 CPNE3 ATG7 DSP DSG1 HUWE1 ACLY PKP1 CST3 TTR LYZ SNAP29 PTAFR TSPAN14 TIMP2 DEFA1B PRSS3 PRSS2 DEFA4 ADA2 SLC2A3 PRKCD HP ANPEP MME ATP6AP2 FUCA2 CTSS CTSB FCN1 CSNK2B CFD UBR4 IQGAP1 BPI SURF4 RAP1B VCL XRCC6 LTA4H XRCC5 STING1 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n RFT1 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLRB2 IFT70B DYNLRB1 IFT70A IFT25 DYNLT2B IFT74 DYNC2I2 IFT52 DYNC2I1 TRAF3IP1 IFT172 WDR19 KIF17 KIFAP3 DYNC2H1 TNPO1 IFT57 TRIP11 IFT80 IFT56 IFT88 CLUAP1 IFT81 DYNLT5 DYNC2LI1 DYNLT2 KIF3B IFT140 KIF3A TTC21B DYNLL1 KIF3C WDR35 DYNLL2 IFT43 IFT122 IFT20 IFT22 IFT46 IFT27 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME SULT1E1 GGT3P SULT1A4 ABCC4 SULT1A3 GSTM1 SULT2A1 ABCC5 SULT1C4 GSTT1 CNDP2 CYP2E1 UGT1A10 GGT1 UGT2B15 ACY1 GSTP1 NAT1 NAT2 GGT5 ABCG2 UGT1A1 ABCC2 UGT1A9 ABCC3 UGT1A6 ABCC1 GGT7 GGT6 SULT1A1 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) DHCR7 SC5D EBP DHCR24 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MTFMT MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MTIF2 MRPL46 MTIF3 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins SCP2 PHYH TYSND1 HSD17B4 ACAA1 ACOX1 AGPS LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis SLC2A1 LALBA B4GALT1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 EP300 HNF1B RBPJ MAML2 CREBBP MAML1 NEUROG3 KAT2B KAT2A MAMLD1 SNW1 HES1 ONECUT3 ONECUT1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB PRKAR2B CALM1 PRKACA PRKACG ADCY4 NBEA PRKACB ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A ADCY9 PRKAR1B BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants ALK GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis NECAP1 CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SNX5 NAPA TBC1D8B SNAPIN AP1G1 SORT1 DTNBP1 AP1S2 PUM1 AP1B1 TPD52L1 AP1S1 GOLGB1 AP1S3 YIPF6 TGOLN2 ACBD3 TFRC AP1M2 AP1M1 FTH1 IGF2R CLINT1 SH3GL2 FTL VAMP2 ARF1 AP4E1 BLOC1S1 AP3B1 TXNDC5 HSPA8 AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 RAB5C SNX9 ARRB1 PICALM PIK3C2A OCRL GAK HIP1R INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption RSC1A1 SLC2A2 SLC5A1 SLC2A5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC1A5 SLC7A11 SLC6A20 SLC7A10 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC36A4 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC6A6 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GGCX GP5 F11 GP1BA F9 F8 GP9 F10 GP1BB DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere H2AX CENPT CENPU CENPH CENPI HJURP CENPK RSF1 CENPL MIS18BP1 CENPM OIP5 CENPN CENPW CENPX CENPO MIS18A CENPP H2AJ CENPQ CENPS H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KNL1 NPM1 H2AC19 H2AC14 H2BC12L SMARCA5 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RUVBL1 H4C9 RBBP4 ITGB3BP RBBP7 H2AZ2 CENPA H2AC20 CENPC DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus RB1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P RPIA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TAB3 TAB2 TAB1 UBA52 IRAK2 TICAM2 TICAM1 TLR4 LY96 UBB TRAF6 CD14 UBC RPS27A MAP3K7 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis TNFRSF10B TNFRSF10A ITCH FAS FASLG UBA52 STUB1 OGT UBB MLKL UBC RPS27A TRADD UBE2L3 CASP8 FLOT1 TNFSF10 FLOT2 PDCD6IP RIPK3 TRAF2 HSP90AA1 CDC37 PELI1 BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 FADD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing SNU13 SNW1 SNRPD2 SNRPD1 SNRPD3 TCERG1 SNRPG SNRPC SRSF8 SNRPA HTATSF1 SNRPE RBM25 SNRPF SNRNP70 PRPF40A SNRPB PPP1R8 SRSF10 SRSF12 MTREX RBM39 PPIL2 NCBP1 NCBP2 PQBP1 SRRT LSM5 LSM4 LSM3 SNRNP200 LSM2 LSM7 FUS LSM6 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA3 TRA2B GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC DHX16 RBMX HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 SAP18 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD STEEP1 SF3B4 GPATCH1 SF3B5 PNN SF3B2 SF1 SF3B3 DHX8 SF3B6 PRKRIP1 SF3B1 CWF19L2 SF3A3 WDR70 SF3A1 DHX35 SF3A2 PRPF38A XAB2 SMU1 PHF5A NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A TXNL4A CACTIN SNRPN PRPF31 RBMX2 CHERP SNIP1 IK PRP4K LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 PTBP1 YJU2 PLRG1 LSM8 SNRPA1 PPWD1 DNAJC8 USP39 SART1 PUF60 TFIP11 SNRPB2 SYF2 C9orf78 LUC7L3 PPIL1 NSRP1 SNRNP40 WBP4 RNF113A MFAP1 RBM42 BUD13 PPIL3 PPIL4 FAM50A SRRM2 AQR CRNKL1 PRPF19 HNRNPH1 HNRNPH2 CWC25 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 RBM7 HNRNPU EIF4A3 CASC3 MAGOH CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D DDX39B POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 GTF2F1 RBM8A GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ACIN1 ALYREF UPF3B MAGOHB RNPS1 DDX41 ZNF830 DHX9 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins TEX101 NEGR1 DPM1 DPM2 DPM3 XPNPEP2 GPLD1 GP2 PRSS21 CD109 PRSS41 VNN1 VNN2 TECTA TECTB GPIHBP1 PGAP1 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 PLET1 CPM PSCA LY6E RTN4RL2 LYPD6B PIGS PIGU PIGT PIGO RTN4RL1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGK FOLR2 PIGM PIGL PIGG PIGF PIGH OTOA LY6K RAET1G RAET1L LY6D IZUMO1R LY6H CEACAM7 NRN1L SPRN CEACAM5 FCGR3B SPACA4 MDGA2 LY6G6C MELTF RECK LY6G6D MDGA1 MSLN NRN1 ART3 ART4 LSAMP NTNG1 NTNG2 BST1 GPAA1 CD52 NTM ULBP2 PRND CNTN5 ALPL CNTN3 PLAUR CNTN4 ALPG ALPI OPCML SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function PPP1CC SHOC2 ARAF PPP1CB RAF1 BRAF YWHAB MRAS NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 NEURL1 YBX1 EGFR UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B NOTCH3 MIB2 EGF TACC3 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism NUDT19 ACBD5 PHYH SLC25A17 ACOXL ACOX2 ACOX3 ACBD4 HACL1 HAO2 ACOT8 EHHADH HSD17B4 NUDT7 ACAA1 PECR AMACR DECR2 ABCD1 SLC27A2 CRAT CROT ACOT4 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME AKR1C1 CYP3A4 UGT2B17 HSD11B1 HSD11B2 ALB SERPINA6 UGT1A3 ABCB1 UGT2B7 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle ARHGAP12 GIT2 EPHA2 WASL PARD6B ARHGEF7 CCP110 PAK4 CEP97 SPTBN1 PEAK1 PARD6A ZNF512B VANGL1 USP9X PAK6 PAK1 SH3RF1 SPTAN1 IQGAP1 PAK2 CLTC PIK3R1 NCK2 GIT1 NCK1 TXNL1 TPM4 TPM3 RHOV CDC42 WDR6 MYO9A DST MAP3K11 DEPDC1B DLG5 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs POLR2I H2AC6 POLR2J H2AC7 POLR2K H2AX POLR2L TNRC6A RAN H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 IPO8 H2BC1 H4C9 POLR2A POLR2B POLR2C H2AB1 POLR2D H2AZ2 POLR2E H2AC20 POLR2F AGO1 POLR2G AGO2 POLR2H H2AC8 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants ALK NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions KIRREL3 ACTN3 KIRREL1 KIRREL2 MAGI2 WASL SPTAN1 PIK3R2 IQGAP1 PIK3R1 PIK3CA NPHS1 ACTN1 NCK2 NCK1 ACTN2 SPTBN1 ACTN4 FYN PIK3CB CD2AP CASK CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism SLC44A2 BHMT SLC22A4 DMGDH CHDH SARDH ALDH7A1 SLC44A1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell SCUBE2 SHH GPC5 NOTUM IHH ADAM17 DHH DISP2 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway POLB OGG1 XRCC1 LIG3 NEIL2 NEIL1 PNKP ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 DGAT2L6 AWAT2 DGAT2 DGAT1 MGLL PNPLA2 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles FMO1 FMO2 FMO3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex CHUK PELI1 UBE2N IRAK1 IKBKB UBE2V1 TRAF6 PELI3 PELI2 IKBKG DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling ITCH UBB UBA52 SRC NEDD4 UBC RPS27A WWP1 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants STAT5A STAT5B PIM1 GAB2 NOX4 GRB2 SOS1 CDKN1A PIK3R1 PIK3CA NRAS HRAS FLT3 BCL2L1 PTPN11 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism ORMDL3 CSNK1G2 ST6GALNAC5 STS ARSA NEU2 NEU3 B3GNT5 SUMF2 SUMF1 NEU1 HEXB ALDH3B1 ST8SIA5 HEXA ST3GAL5 GLB1L3 CTSA DEGS1 GLB1L2 ARSL GLB1L GLB1 ARSJ ARSK ARSH ARSI ARSF ARSB GLA ARSG ARSD PSAP ABCG2 FUT2 FUT1 B3GALT4 M6PR CYB5B SMPD3 SMPD2 CERK ASAH1 GBA3 GBA2 OSBP MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 B4GALT6 PLPP3 PLPP2 PLPP1 UGCG UGT8 ALDH3B2 SGPL1 B4GALT5 B4GALNT1 ST6GALNAC6 KDSR B3GALNT1 ACER2 FA2H ACER1 ACER3 DEGS2 GAL3ST1 SPTLC1 SMPD4 SPTLC2 SPTLC3 A4GALT CERS3 CERS4 CERS5 CERS6 SPHK2 CERS1 CERS2 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB SPTSSA ORMDL1 SGPP2 SGPP1 GALC VAPA VAPB GBA1 ABCC1 SMPD1 ST3GAL2 ST3GAL3 GM2A SPHK1 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC MUC1 MUC2 MUC12 MUC7 MUC13 MUC4 MUC6 GALNT3 MUC15 MUC16 MUC17 MUC19 MUC5B MUCL1 MUC20 MUC21 MUC3A MUC5AC MUC3B METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids HSD17B1 STS CYP24A1 SRD5A3 OSBPL1A TM7SF2 GGPS1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK INSIG2 SAR1B INSIG1 CYP19A1 ACACB ACACA SREBF1 PMVK SCAP SC5D FDFT1 FDPS LHB MBTPS1 SLCO1B1 SEC24B SLCO1B3 SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SEC24D KPNB1 HSD11B1 SEC24C HSD11B2 SMARCD3 MBTPS2 SERPINA6 CHD9 ABCB11 HELZ2 LBR OSBP TGS1 TBL1X CYP11A1 NCOA1 MED1 GC NCOA2 CREBBP NCOA6 TSPOAP1 CYP2R1 HSD3B7 AKR1C1 AKR1D1 NR1H4 TBL1XR1 AKR1C2 AKR1C4 CARM1 CYP7B1 CYP7A1 CYP27A1 LRP2 SRD5A2 SLCO1A2 SRD5A1 CYP17A1 LDLRAP1 RAN CH25H CUBN OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 AKR1B15 HSD17B14 HSD17B11 HSD17B2 ACOT8 HSD17B4 SLC27A2 HSD17B3 HSD17B12 CYP8B1 STARD3 STARD4 STAR STARD6 FASN IDI2 STARD3NL MSMO1 TSPO HSD17B7 ACAT2 NSDHL BAAT STARD5 ARV1 EBP SLC10A1 ACOX2 SLC10A2 DHCR24 PIAS4 SLC51A PLPP6 SLC51B SLC27A5 POMC UBE2I VDR ALB FABP6 AMACR RXRA SUMO2 CGA PPARA AKR1C3 FDX1 FDXR FDX2 LGMN HSD3B2 CYP11B2 CYP46A1 CYP21A2 CYP39A1 HSD3B1 CYP27B1 CYP11B1 AKR1B1 ABCC3 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling PTPN4 MAPK8 SQSTM1 STAT3 MAP2K1 IL4 PTPN12 IL18RAP IL13 MAP3K8 TBK1 UBE2V1 NFKB2 HMGB1 ALOX5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 CASP1 IL1RAPL1 IL18 TRAF2 IL1A IL1B PELI1 PSMD8 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PSMD3 PSMD1 IKBKG BTRC PTPN11 MAP3K7 SKP1 GSDMD CHUK PTPN6 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 APP IL1RN PSMA1 PSMA2 UBA52 TOLLIP PSMD12 IL1R2 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 MYD88 PSMA7 RELA IL36A PSMB6 IL36B PSMB7 PSMB4 PSMB5 UBB IL36G IL1F10 PSMB2 NKIRAS1 PSMB3 UBC NKIRAS2 IKBIP PSMB1 RPS27A ADRM1 NFKB1 SEM1 IRAK4 NFKBIA RBX1 PSMC5 PSMC6 PSMC3 PSMC4 LRRC14 PSMC1 USP14 IL33 PSMC2 NLRX1 MAP3K3 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER IL36RN USP18 IRAK2 S100A12 IL1RL1 N4BP1 IL1RL2 S100B TNIP2 SAA1 PTPN18 IL37 PTPN20 PTPN23 SMAD3 PTPN13 PTPN14 IL18BP SIGIRR PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 IRAK3 CTSG TP53 TIFA ALPK1 MAP2K4 MAP2K6 IL1R1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 PRKCZ NRAS REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity GJA1 TJP1 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud GREM1 GDNF EYA1 ITGB1 FOXC2 FOXC1 SIX1 HOXD11 SLIT2 HOXC11 HOXA11 SALL1 SIX2 ROBO2 WNT11 RET GFRA1 NPNT PAX2 BMP4 ITGA8 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity KNG1 A2M PLAUR HRG C1QBP KRT1 F12 SERPING1 KLKB1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors TP63 PHF20 TP53 ZNF385A POU4F1 POU4F2 PPP1R13B TP53BP2 BANP TP73 AKT2 PPP1R13L AKT3 AKT1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation DNM2 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 GJB3 AP2M1 GJB6 GJB5 GJB7 GJD4 GJD3 CLTCL1 GJC1 GJD2 GJA10 MYO6 DAB2 CLTC DNM1 CLTA TJP1 GJA1 GJB2 GJB1 CLTB NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF5 TIAM2 OBSCN ARHGEF4 ARHGEF7 ARHGEF26 NGEF ARHGEF6 FGD1 FGD2 RAC1 KALRN GNA13 FGD3 FGD4 BCL2L11 ARHGEF33 ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 AATF VAV1 MAPK8 NGFR TIAM1 NGF SOS1 VAV3 VAV2 RASGRF2 ARHGEF18 ARHGEF10L BAD AKAP13 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 ECT2 PREX1 SOS2 MCF2L NET1 ABR ARHGEF16 ARHGEF40 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC MMACHC GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking DNM2 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 GJB3 AP2M1 GJB6 GJB5 GJB7 GJD4 GJD3 CLTCL1 GJC1 GJD2 GJA10 MYO6 DAB2 CLTC DNM1 CLTA GJA1 GJB2 GJB1 CLTB NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 NCBP1 NCBP2 UPF1 RPS27A EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 GSPT2 RPL29 GSPT1 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 PABPC1 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 ETF1 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases GSDMD CASP3 CALM2 CASP5 CASP4 CALM1 SERPINB1 IL18 IL1B CALM3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR PPP2CA SPRED2 PPP2CB SPRED1 UBA52 NCBP1 NCBP2 UBB UBC RPS27A CBL HNRNPM HNRNPF TIAL1 TIA1 RBFOX2 ESRP2 NRAS GAB1 FRS3 MAPK1 HRAS MAPK3 PLCG1 POLR2A FRS2 POLR2B POLR2C BRAF POLR2D POLR2E POLR2F POLR2G ESRP1 FLRT2 POLR2H FLRT1 POLR2I PTBP1 POLR2J POLR2K PPP2R1A POLR2L SOS1 TGFBR3 GTF2F1 GTF2F2 ANOS1 GIPC1 FGFRL1 FLRT3 KLB FGF1 FGFBP1 FGF2 FGFBP2 FGF3 FGFBP3 FGF4 FGF6 FGF7 FGF9 FGF20 HNRNPA1 HNRNPH1 FGF23 FGF22 FGF16 MKNK1 FGF19 FGF18 SPRY2 PIK3CA PIK3R1 FGFR4 FGF10 GALNT3 PTPN11 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 PROS1 PROC F5 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation AP2B1 ATP6V1H CD8B AP2A1 AP2S1 AP2A2 AP2M1 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 DLD PDP2 GSTZ1 PDHB CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 PRKCG KPNA2 ADCY9 PRKAR1B SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants HRAS KRAS NRAS SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) CTNNB1 PAX6 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 FFAR4 LEP FFAR1 GCG GNG13 GRP GPR119 GNB1 TCF7L2 GNAT3 DPP4 GNB3 CDX2 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease STAT5A STAT5B SOS1 KIT PIK3R3 PIK3R2 PIK3R1 PIK3CA LCK JAK2 STAT1 NRAS LYN STAT3 HRAS YES1 FYN SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 H2AX RAC1 MTMR1 H3-3B TFRC H3C8 VAV1 H2AJ SCFD1 H3C15 ATP6AP1 PAK1 PAK3 PAK2 KLC1 VHL KLC4 H2BC9 KLC3 H2BC8 KLC2 H2BC5 DOCK3 H2BC3 FRS3 H2BC1 TIAM1 HMOX2 H2AB1 H2AC8 H2AC6 H2AC7 JAG1 VCP ITSN2 DBT RTKN SOWAHC ARHGEF10L STK10 AKAP13 SLK H2BC26 H2BC21 ARHGEF11 ARHGEF10 NCKAP1 ARHGEF12 NCF1 YWHAG ARHGEF17 STARD8 NCF2 NCF4 RHOB PDPK1 CIT SNAP23 H2BC17 DAAM1 BRK1 ARHGAP6 ARHGEF3 H2BC12 ARHGEF1 DOCK10 H2BC13 ARHGEF2 SYDE1 H2BC14 PKN3 ARHGAP42 H2BC15 PIK3CA BAIAP2L1 ARHGEF25 PICALM RAC3 ARHGEF28 IQGAP3 LCK GIT1 SWAP70 STOM RHPN2 ARAP2 H2BC11 CYBB ECT2 STARD13 ARAP3 JUP OCRL CAVIN1 CYBA BCR CDC42 PCDH7 AMIGO2 MYO9A NET1 CTTN NOXO1 ANLN ARHGAP17 ARHGAP15 DIAPH1 ABR CSK ACTC1 RACGAP1 DLC1 PKN2 SLITRK3 PKN1 NHS H2AZ2 TNFAIP1 SLITRK5 RND3 NCKAP1L CKB WASF1 SEMA4F WASF2 ARHGEF40 CKAP4 NISCH PLEKHG2 IL32 KCTD13 GIT2 ARHGEF15 PLEKHG5 TRIP10 ARHGAP26 BAIAP2 ARHGEF19 TAOK3 RHOC ABI2 TIAM2 OBSCN NOXA1 ABI1 ARHGEF4 NOX3 ARHGEF7 NGEF NOX1 FERMT2 ARHGEF6 FGD1 C1QBP FGD2 GNA13 FGD3 FGD4 ARHGEF39 PLXNB1 SLC1A5 KLK3 KLK2 KDM4C RHOU GJA1 ACTB PTK2B CYFIP2 WIPF1 SCAI WIPF2 WDR91 WIPF3 ANKFY1 WDR81 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 BTK GMIP CDC42EP5 CDC42EP4 CDC42EP3 ARPC1B CDC42EP2 ARPC1A FGD5 CFL1 CHN2 WASL CHN1 FARP1 DEF6 WDR11 VMA22 WAS SHKBP1 GOPC ROPN1 FILIP1 TAX1BP3 FAM13B NF2 CCT6A FAM13A PRC1 POTEE GOLGA8R RALGAPA1 FAM91A1 TEX2 ARMCX3 DDRGK1 TUBA1B NSFL1C ARHGAP11A ZNF512B ARHGAP11B TAGAP CCT2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 MYH9 ARFGAP2 BLTP3B NCKIPSD DVL1 SH3BP1 DVL2 WHAMM DVL3 GOLGA3 BAIAP2L2 SPATA13 ARPC4 TMEM87A ARPC5 FAF2 ARPC2 AKAP12 ARPC3 HINT2 CTNNA1 GRB7 SH3PXD2A STMN2 RHOH ACTR3 KIF14 RHOF ACTR2 RHOD RND1 STIP1 RHOV EPSTI1 PLEKHG4B WDR6 EMC3 CCT7 PLXNA1 PRAG1 PLXND1 WASF3 SYDE2 FAM83B ANKRD26 ARHGAP44 DST DOCK11 RRAS2 BCAP31 ARHGAP40 BASP1 ALDH3A2 TMEM59 RALBP1 CCDC88A KCTD3 PREX2 MYL9 FAM135A ARHGAP45 VANGL2 ARHGAP19 ARHGAP18 UBXN11 AAAS TOR1AIP1 DLG5 CPD ARHGAP12 WWP2 PKP4 ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 SFN ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 LIN7B RASGRF2 USP9X ARHGEF9 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 FMNL3 HSP90AA1 PRKCB ARHGAP39 SRGAP3 LIMK2 SRGAP2 LIMK1 SRGAP1 RHOT2 MYH14 MYH10 RAP1GDS1 MFN1 MFN2 MYO19 TRAK2 DOCK7 MRTFA SENP1 SRRM1 PTPN13 AR DDX39B TRAK1 PRKCA PIN1 CCP110 CEP97 ARHGAP10 SRF PLK1 SRC STAM CDH1 HGS CTNNB1 STAM2 YWHAB FARP2 MAPK1 PLD2 MAPK3 KIDINS220 FRS2 MAPK14 MAPK11 RAPGEF1 SOS1 PARD6B ARHGEF18 PRKCZ RHOA PARD6A XPO1 PGRMC2 ARL13B DDX4 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO NCOA2 ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L CFTR ARHGDIB EMD TMPO PLEKHG3 YWHAQ ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 CALM1 ARHGEF5 RAB7A EPHA2 YWHAE VAMP3 ARHGEF26 PPP1R12A GARRE1 SHMT2 PPP1R12B CDC25C PPP1R14A PLD1 IQGAP2 KALRN RHOBTB3 ARHGAP21 LMAN1 LMNB1 STX5 YKT6 PAK4 NDUFA5 MCF2 MCAM ERBIN YWHAH HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB RAB9A ESYT1 RAB9B YWHAZ PPP1CB ABCD3 RAC2 S100A9 S100A8 RHOT1 PLIN3 CAV1 VAV3 PTK2 PFN1 VAV2 FLNA PFN2 UACA HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 PAK6 MSI2 PAK5 RHOBTB1 MYO9B ACTG1 RHOBTB2 TRA2B MYO6 ABL2 STK38 RBBP6 RNF20 SPEN CPSF7 KDM1A TMOD3 NCK2 ACTN1 NCK1 TXNL1 COPS4 COPS2 EVL CDC37 PHIP SOS2 PDE5A VIM HNRNPC RBMX DBN1 CUL3 RASAL2 MEN1 SPTBN1 LAMTOR1 MYLK MYL12B CDKN1B SPTAN1 MYH11 ABL1 TPM4 TPM3 MYL6 CCNE1 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MTR MAD1L1 CDCA8 MUC13 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 DLG4 PIK3R4 RCC2 NDC80 ZWINT LBR KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 FLOT1 NDEL1 SEC13 NUDC FLOT2 NUP133 PIK3C3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SAMM50 SPC24 MAD2L1 CENPS NUP37 SPC25 MTX1 SH3RF1 STEAP3 LRRC41 DSP DSG1 DSG2 CAPZB TJP2 PRKCD KIF5B KIF5A H2AC19 H2AC14 H2BC12L PIK3R3 IQGAP1 PIK3R2 PIK3R1 H4C9 ZAP70 MAP3K11 H2AC20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis HSD17B1 AKR1B15 HSD17B14 HSD17B11 HSD17B2 CYP19A1 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers DKK2 H2AX DDX46 DDX42 RBM17 CHD8 MYOG MYOD1 TCF4 H3-3B SMNDC1 U2SURP H3C8 H2AJ CTNNB1 H3C15 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 H2BC9 SF3A1 H2BC8 SF3A2 H2BC5 ZMYND8 PCK1 PHF5A CHD5 H2BC3 IKZF1 IKZF2 PHF6 H2BC1 IKZF3 ZNF687 SNRPN TCF19 ZNF592 ZNF827 CHERP MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 SNRPA1 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 SNRPG CHD9 SNRPE SNRPF MBD3 SNRPB H2BC26 H2BC21 WDR5 EP300 GATAD2B GATAD2A H2BC17 H2BC12 CHD7 H2BC13 H2BC14 FBP1 NKD2 FAM124B H2BC15 CREBBP HDAC2 H2BC11 CBX1 TCF3 MAFK CHD4 RBBP4 CHD3 NFE2L2 RBBP7 H2AZ2 AXIN2 MTA2 CDC73 SUPT16H SKIC8 CTR9 RTF1 CHD2 LEO1 PAF1 SSRP1 MTA1 HDAC1 MTA3 UBE2I CBX3 SUMO1 G6PC1 TCF12 H2AC19 H2AC14 H2BC12L NR2C2 IGF2 NQO1 ADNP2 ADNP CTCF CHD1 CHD6 DHX15 H4C9 H2AC20 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL OFD1 CPAP TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion GNA11 GNAQ MARCKS GNA14 PRKCA PLCB3 GNA15 PLCB1 CHRM3 PLCB2 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus YWHAZ JAG1 ADAM10 DLL4 PSENEN PSEN2 NOTCH4 PSEN1 APH1A NCSTN APH1B DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type CSPG5 CSPG4 NCAN BGN DCN BCAN VCAN CHST14 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle MSI2 ACTG1 RHOBTB2 TRA2B MYO6 STK38 CUL3 TMOD3 ACTN1 TXNL1 HSP90AA1 CCT6A CDC37 PHIP CCT7 HNRNPC RBMX DBN1 SRRM1 HSP90AB1 DDX39B CCT2 TWF1 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MDM2 PSMA7 PSMB6 PSMB7 MTBP PSMB4 BANP PSMB5 UBB PSMB2 PSMB3 SRC UBC CTNND1 PSMB1 RPS27A ADRM1 CDH1 SEM1 CTNNB1 EPS15 PSMC5 CBLL1 PSMC6 PSMC3 PSMC4 PSMC1 RACK1 PSMC2 CTSL DNM2 CTSS CTSB CTNNA1 JUP PSMD8 PSMD6 PSMD7 PSMD2 VCL PSMD3 PSMD1 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage CDA UPP2 UPP1 TYMP TK2 TK1 MAPDA GMPR2 ADK HPRT1 AMPD1 GMPR AMPD2 AMPD3 DCK UCKL1 APRT UCK2 DGUOK UCK1 PNP PUDP ADA SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport GLTP ARF1 CPTP PLEKHA8 CLN3 ESYT3 ESYT2 ESYT1 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria DCXR INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism POM121C NUP42 NUP62 NUP43 TPR CALM1 NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 INPPL1 NUP155 PLD4 INPP5B NUP153 PLCZ1 INPP4A NUP93 INPP4B NUP50 INPP5D INPP5J NUP35 PLCE1 NUP54 ITPK1 ITPKB ITPKC PLCB4 MTMR9 SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 MTMR7 PLCD4 IPMK PLCD1 MINPP1 NUP37 IPPK NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K1 NUDT3 PLCG1 IP6K3 NUDT4 NUP107 MIOX ISYNA1 INPP1 INPP5A IMPA1 PLCG2 IMPA2 PLCB3 PLCB1 PLCB2 NUP160 PTEN NUP85 SEC13 NUP133 OCRL IP6K2 NUP205 POM121 NUP188 AAAS SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC35C1 POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 SLC22A5 NUP153 NUP93 SLC35A3 NUP50 SLC17A5 NUP35 NUP54 SLC1A1 SLC2A9 SLC24A1 SLC3A1 SLC2A2 SLC1A3 SLC40A1 SLC5A1 SLC3A2 SLC6A3 HEPH SLC35A1 SLC5A7 SLC6A20 NUP37 SLC67A1 SLC11A2 AVPR1B SLC6A19 AVPR2 SLC36A2 AVP AVPR1A SLC6A14 SLC26A2 SLC34A3 SLC34A2 SLC34A1 SLC7A7 SLC7A9 NUP107 SLC5A5 SLC17A8 GCKR CP SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 SLC5A2 SLCO1B1 SLCO1B3 SLC33A1 SLC6A5 SLC9A6 SLC26A4 SLC26A3 SLC6A2 SLC9A9 SLC12A3 GCK SLC22A12 SLC2A1 SLC2A10 SLC12A1 SLC12A6 NUP160 SLC29A3 HK1 SLC24A4 SLC20A2 NUP85 SLC35A2 SLC16A1 SLC24A5 SLC4A1 RHAG SEC13 NUP133 NUP205 POM121 NUP188 AAAS TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE TICAM1 TLR3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation EP300 HSF1 RPTOR CREBBP FKBP4 HSPA1A CAMK2B HSP90AA1 HSPA1B CAMK2D HSPA1L CAMK2A HSPB8 AKT1S1 HSBP1 CRYAB PTGES3 HSPA2 HSP90AB1 CAMK2G HSPA8 MTOR DNAJB1 MLST8 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 HDAC3 HDAC1 HDAC2 NGF NGFR PRDM4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism ALAS2 ALAS1 FECH COX15 UROS CPOX PPOX SLCO1B1 ALAD SLCO1B3 UROD HMBS COX10 GSTA1 HMOX1 ABCG2 UGT1A1 ABCC2 FABP1 UGT1A4 ALB ABCC1 HMOX2 BLVRB BLVRA INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism TKT PRKAG2 STK11 KCNB1 KCNS3 SNAP25 PFKFB1 VAMP2 STX1A AGPAT1 RAP1A ACACB ACACA PPP2R1B PPP2R1A STXBP1 CACNA2D2 MLXIPL ADIPOQ SLC2A1 ADIPOR1 ADIPOR2 ADRA2C ADRA2A CACNA1C CACNB2 ABCC8 CACNB3 CACNA1A CACNA1E PPP2R5D PRKAA2 PPP2CA PPP2CB INS PRKACG PRKACB SLC2A2 MARCKS SYT5 MLX GLP1R FASN ACSL4 GNGT1 CHRM3 ACSL3 FFAR1 ACLY GNGT2 RAPGEF3 RAPGEF4 CACNA1D AHCYL1 ADCY9 PRKAR1B PRKAR2B CD36 PRKACA TALDO1 ADCY4 PRKCA PLCB3 ADCY3 PLCB1 PLCB2 ADCY2 ADCY1 GNAQ ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 GNG7 PRKAR1A GNG8 PRKAB2 AKAP5 KCNJ11 KCNG2 IQGAP1 GCGR GNA14 GNA15 GNA11 GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 KCNC2 GNB5 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 LDB1 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 EBF1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 LHX2 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling PPP2CA FGF9 PPP2CB FGF20 FGF23 PPP2R1A FGF16 MKNK1 FGF18 SPRY2 UBA52 MAPK1 MAPK3 UBB FRS2 BRAF FGF1 FGF2 UBC PTPN11 FGF4 RPS27A CBL DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 OGG1 NTHL1 APEX1 TDG MBD4 SMUG1 MPG DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair RAD1 ATM RAD9B ATR RAD9A MSH6 SEM1 MSH2 MSH3 PMS2 MLH1 MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 RAD51B RAD51D OGG1 RAD51C DNA2 NTHL1 RHNO1 BLM NEIL3 RAD51AP1 NEIL1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A11 SLC22A8 SLC22A12 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling XAF1 PTPN6 IFNAR1 ADAR OASL KPNA1 OAS1 OAS3 IRF8 UBA52 IRF6 IRF9 ABCE1 SAMHD1 TYK2 JAK1 HLA-B HLA-A MX2 MX1 STAT2 UBB UBC RPS27A IRF5 PSMB8 IFNB1 SOCS3 USP18 STAT1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IRF3 IFNA21 IFNA14 IFNA16 IFNA17 IFNA10 IFITM3 IRF4 IFITM1 IFITM2 IFIT5 IFI35 IFIT1 KPNB1 IFIT3 HLA-H IFIT2 HLA-C HLA-F HLA-G HLA-E EIF2AK2 ISG15 RSAD2 IFI27 EGR1 RNASEL SOCS1 IFI6 IRF1 BST2 IRF2 IRF7 OAS2 IP6K2 GBP2 PTPN1 PTPN11 ISG20 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 NEIL1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium ARL3 RP2 CYS1 NPHP3 UNC119B UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes AMN CTRB1 LMBRD1 PRSS3 PRSS1 CBLIF ABCD4 CUBN TCN1 CTRB2 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 NUP93 NUP50 NUP35 NUP54 CPSF1 CSTF2 NUP37 CLP1 POP5 POP7 TSEN15 POP1 POP4 RTCB ZBTB8OS TSEN2 TSEN54 TSEN34 DDX1 C2orf49 RTRAF XPOT FAM98B NUP107 NUP160 TRNT1 NUP85 CPSF4 RPP30 RPP38 SEC13 RPP21 RPP25 NUP133 RPP40 ELAC2 NUP205 POM121 NUP188 AAAS RPP14 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation CHUK PELI1 UBE2N IRAK1 IKBKB UBE2V1 TRAF6 PELI3 PELI2 IKBKG DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 FGFR4 KLB PLCG1 FGF1 FGF2 FGF4 FGF6 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC7A7 SLC3A2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation UBE2N MAPKAPK3 TAB3 MAPKAPK2 TAB2 TAB1 IRAK1 UBE2V1 NOD1 NOD2 RIPK2 IRAK2 MAP2K3 TRAF6 MAPK14 IKBKG MAP3K7 MAP2K6 MAPK11 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling HLA-DRB3 HLA-DRB1 CD3G CD3E CD3D UBE2D1 INPP5D HLA-DPA1 HLA-DQB2 HLA-DQB1 TRBV12-3 PAK1 TRBV7-9 PAK3 PAK2 UBE2D2 TRAV8-4 HLA-DPB1 PLCG1 TRAC GRAP2 CDC34 PRKCQ UBE2V1 TRAV19 HLA-DRA PIK3CB UBE2N TAB2 PDPK1 PAG1 PIK3CA LCK PSMD8 IKBKB PSMD6 PSMD7 TRAF6 CSK PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK CD4 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RIPK2 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 TRAT1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTPRC PTPN22 PLCG2 WAS VASP PTEN TRBC1 ENAH PIK3R2 PIK3R1 NCK1 TRAV29DV5 HLA-DQA2 EVL HLA-DRB5 HLA-DRB4 ITK FYB1 PTPRJ ZAP70 LCP2 LAT CD101 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency MCCC2 PCCB ACACA MCCC1 HLCS PC PCCA APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEK2 BUB1B CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism ASAH2 ST6GALNAC5 STS ARSA NEU2 B3GNT5 NEU3 GALC SUMF2 SUMF1 HEXB NEU1 HEXA ST8SIA5 ST3GAL5 GLB1L3 CTSA GLB1L2 ARSL GLB1L GLB1 ARSJ ARSK ARSH ARSI ARSF ARSB GLA ARSG ARSD PSAP GBA1 FUT2 FUT1 SMPD1 M6PR B3GALT4 ST3GAL2 ST3GAL3 SMPD3 SMPD2 CERK ASAH1 GBA3 GBA2 GM2A ENPP7 B4GALT6 UGCG UGT8 B4GALT5 ST6GALNAC6 B4GALNT1 B3GALNT1 GAL3ST1 SMPD4 A4GALT SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells CBX6 PHC2 NFATC2 NFATC1 GATA3 PHC1 MTA2 CBX4 CBX2 ASH2L HDAC10 HDAC11 TNF JUN PHC3 MAML2 MAML1 MEN1 RUNX3 MAF BMI1 TPST2 RUNX1 RING1 FOS RNF2 NOTCH1 NOTCH2 MTA1 HDAC1 BATF MTA3 IL4R HDAC4 TBX21 SATB1 SMARCA4 CCL3 SNW1 IL4 IL13 KMT2A IRF4 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 IFNG DPY30 MBD3 WDR5 KLF13 STAT5A EP300 STAT5B GATAD2B TBL1X GATAD2A RBPJ POU2F2 HDAC5 HDAC2 CREBBP ETS1 POU2F1 HDAC8 STAT4 HDAC9 NCOR1 HDAC6 IL12RB2 TBL1XR1 HDAC7 CHD4 RBBP4 CHD3 RBBP5 YY1 IL5 RBBP7 STAT6 CBX8 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage TK1 CDA UPP2 UPP1 DCK UCKL1 TYMP UCK2 UCK1 TK2 PUDP PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation POLR2I POLR2J POLR2K POLR2L CCNK CCNT2 ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX BID BAX DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V GP5 VWF GP1BA GP9 GP1BB EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin HRAS SOS1 MMP3 PRKCA HBEGF EGFR NRAS COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport COG7 COG6 GOSR1 COG5 COG4 INS COG3 TMED2 COG2 ARF4 COG1 DYNC1I1 ANK2 ANK3 ANK1 NAPA DYNC1H1 NAPB ACTR1A GORASP1 DCTN6 GOLGA2 DCTN5 NAPG STX5 GOLGB1 SPTBN4 DCTN4 YKT6 SPTBN5 RAB1A SPTA1 TMED10 CAPZA3 ACTR10 COPZ2 SPTBN1 COPZ1 GOSR2 SPTBN2 RAB1B USO1 CD59 SPTAN1 SPTB KDELR3 DCTN1 FOLR1 BET1 ARF1 CAPZB BET1L NSF CAPZA1 CAPZA2 DCTN2 DCTN3 DYNC1LI1 DYNC1LI2 ARF5 ARCN1 GBF1 TMED3 TMED7 TMED9 CD55 KDELR2 ARFGAP2 KDELR1 COPG2 COPG1 COPB2 COPA DYNLL1 COPB1 TMEM115 DYNLL2 ARFGAP1 COPE DYNC1I2 ARFGAP3 ARF3 COG8 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway PRKCB PSMA5 AP2A1 PSMA6 PSMA3 AP2A2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PRICKLE1 RAC1 AP2M1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RYK UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 AP2S1 PSMC4 PSMC1 PSMC2 RAC2 AP2B1 CLTB WNT5A PRKCG SMURF2 SMURF1 PRKCA PFN1 WNT11 RHOA PARD6A WNT1 WNT4 FZD1 FZD3 DVL1 FZD2 DAAM1 DVL2 FZD5 WNT5B DVL3 FZD4 SCRIB ROR1 ROR2 FZD7 CLTC ARRB2 RAC3 CLTA FZD6 FZD8 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VANGL2 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase AKAP9 CACNB1 CACNB2 CACNG8 KCNE1 CACNG4 KCNE2 KCNE3 KCNE4 CACNA2D2 KCNE5 KCNQ1 CACNA1C CACNG6 CACNG7 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors MAPK9 MAPK1 MAPK8 MAPK3 FOS JUN MAPK10 MAPK14 MAPK11 ATF2 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) OPN1LW RBP3 AWAT2 RLBP1 OPN1SW DHRS3 OPN1MW DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs CAMKK1 CAMKK2 CALM1 CAMK1 GIT1 RAC1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) FCGR1BP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 PSME1 SEM1 PSME2 PSMC5 PSMC6 PSMB10 PSMC3 PSMC4 PSMC1 PSMB8 PSMC2 PSMB9 MRC1 CD207 MRC2 FCGR1A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion PDS5A ESCO1 ESCO2 RAD21 WAPL STAG1 CDCA5 SMC1A STAG2 PDS5B SMC3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation PRKAR2B PRKACA PRKACG ADCY4 PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ADCY5 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1A GCGR GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 ADCY9 PRKAR1B ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters SLC30A2 SLC39A4 SLC30A1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A5 SLC39A10 SLC39A14 SLC30A3 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2I POLR2J POLR2K POLR2L ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease SOS1 UBA52 GOLGB1 SPTBN1 UBB TRIP11 UBC RPS27A CBL ETV6 STAT5A STAT5B PIM1 GAB2 NOX4 ZMYM2 GRB2 FLT3LG CDKN1A PIK3R1 PIK3CA NRAS HRAS MYO18A FLT3 BCL2L1 PTPN11 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway CDC42 PAK1 CD86 FYN PAK3 VAV1 CD80 PAK2 LCK RAC1 CD28 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events GPHA2 SRC GPHB5 LHCGR ADORA2A PTGDR LHB MC2R RLN2 RLN3 INSL3 RXFP1 RXFP2 PDE3B GRK3 FSHB GPBAR1 FSHR PTGER4 ITGB1 PTGER2 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 GPR84 PRKACG PDE2A PDE3A PRKACB GPER1 PDE8B PDE8A MC4R GRK6 PTGIR PDE4A PDE4D PDE4C PDE11A PDE10A PDE7B PDE7A GLP1R VIPR1 MC3R TSHR VIPR2 AVPR2 SCT AVP ADM PTH1R GNGT1 POMC GPR39 GNGT2 MC1R ADRB1 ADRB2 MC5R HTR4 GLP2R NPSR1 TAAR3P GNAT3 PTH2R HTR6 HTR7 NPS GIP ADCYAP1 ADCY9 HRH2 PRKAR1B DRD1 CRH IAPP P2RY11 ADCYAP1R1 PRKAR2B CGA RAMP2 CALCA DRD5 TSHB RAMP3 PRKACA TAAR8 CALCB TAAR9 CALCRL PTH TAAR6 PDE1B GIPR PDE1A GNAI3 GRK2 ADCY4 TAAR5 ADCY3 PTH2 TAAR2 PTHLH CRHR1 ADCY2 TAAR1 GHRHR ADCY1 ADCY8 GNG10 ADRB3 ADCY7 PRKAR2A ADCY6 GNG3 CALCR GNAI1 ADCY5 GNG2 GNAI2 GNG5 GRK5 GNG4 GNG7 PRKAR1A GNG8 CRHR2 CYSLTR2 GNAZ ARRB1 ITGA5 ARRB2 GCGR SCTR GCG GNG12 ADORA2B GNG11 GNG13 ADM2 GNB2 GHRH GNB1 GNAS GNB4 GNB3 GNB5 VIP RAMP1 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends RAD1 ATM RAD9B H2AX ATR RAD9A HERC2 UBA52 UBB CCNA2 CCNA1 UBC RNF4 RPS27A H2BC9 H3-4 PIAS4 H2BC8 H2BC5 H2BC3 UBE2I H2BC1 PPP4R2 CDK2 TIPIN SIRT6 TIMELESS BRCC3 PPP4C CLSPN TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 H2BC26 TOP3A UBE2V2 H2BC21 HUS1 UBE2N DNA2 MDC1 H2BC17 RHNO1 BLM H2BC12 H2BC13 H2BC14 H2BC15 WRN BRIP1 H2BC11 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 RAD50 RPA3 RAD17 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades CHUK BTK S100A1 CD36 TIRAP NFKB2 MYD88 RELA TICAM1 UNC93B1 LY96 TRAF3 CD14 TLR7 TLR3 HMGB1 NFKB1 IRAK4 NFKBIA TLR1 TLR10 TLR6 TLR5 TLR2 S100A9 S100A8 FGB FGA FGG IKBKB TLR4 IKBKG AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism MCCC2 MCCC1 PPM1K AUH IVD HIBCH GSTZ1 SHMT1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC KGD4 BCKDK BCKDHA DBT BCKDHB DLD GLUD1 GLUD2 SIRT5 TPH2 ASMT AANAT PXMP2 CKB SLC25A12 SLC25A13 GLS QARS1 HAL RIDA SDS AOC1 GAMT SDSL CARNMT1 SLC3A2 UROC1 AMDHD1 HDC CARNS1 RARS1 ACAD8 HNMT HIBADH FTCD PHYKPL ACADSB MARS1 ALDH6A1 SLC44A1 BCAT1 SLC44A2 SLC25A44 SEPHS2 BCAT2 SECISBP2 SLC36A4 EEFSEC SEPSECS DARS1 PSTK LARS1 INMT PIPOX SARS1 GNMT EEF1E1 SCLY KARS1 SLC6A12 ECHS1 IARS1 SLC7A5 AIMP1 AGXT AIMP2 PAOX DDO EPRS1 HAO1 CAV1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DAO DUOX1 CRAT TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 TP53 HSD17B10 SLC22A4 GCSH PAPSS2 PAPSS1 TPH1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 PNMT RPS14 RPS17 DDC RPS16 TH RPL18A DBH RPS19 RPS18 RPL36AL RPL36 ASNS RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 GLUL RPS8 NNMT MTRR RPL23 AHCY RPS5 RPL22 RPS6 MTR RPSA MAT1A SLC6A11 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 DMGDH RPL39L CHDH RPL41 SARDH ALDH7A1 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A GLYAT RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A GLS2 RPLP2 RPL13A GADL1 RPS3A APIP PSMD8 MRI1 RPL37A CSAD PSMD6 ADO RPL10 PSMD7 RPL12 TXN2 PSMD2 RPL11 CBS PSMD3 ENOPH1 RPL36A PSMD1 RPS27L MPST RPS15A GOT1 TXNRD1 TSTD1 GPT BHMT2 RPL14 RPS3 SQOR RPL13 GOT2 RPL15 FMO1 RPS2 SUOX BHMT PSMA5 RPL18 MTAP PSMA6 RPL17 PSMA3 TST ADI1 PSMA4 RPL19 PSMA1 RPL35A CTH ETHE1 PSMA2 RPL23A UBA52 RPL22L1 SLC25A10 FAU CDO1 PSMD12 PSMD11 RPL26L1 PSMD14 PSMD13 PSMA7 ACAT1 OCA2 PSMB6 SLC45A2 PSMB7 PSMB4 DCT PSMB5 TYRP1 TYR PSMB2 PSMB3 PSMB1 RPS27A SLC6A7 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GLDC HYKK TDO2 CKMT1B HOGA1 IDO2 IDO1 GCDH OAZ1 OAZ2 ACMSD OAZ3 AFMID RIMKLA RIMKLB PYCR1 AGXT2 PYCR2 PYCR3 SLC6A8 KYAT3 PHGDH AASS ARG2 OAT HAAO ODC1 CKM QDPR IL4I1 AADAT PAH BBOX1 AGMAT PCBD1 KYAT1 GATM ASRGL1 SAT1 PSPH KMO SMS HGD AZIN2 AZIN1 TAT FAH GRHPR HPD SERINC1 SERINC3 SERINC2 SERINC5 SERINC4 SLC25A2 AMD1 ALDH4A1 DHTKD1 PRODH KYNU AMT PRODH2 ALDH9A1 SRM CKMT2 SRR SLC25A21 NQO1 CRYM TMLHE PSAT1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA OGDH DLST RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription BCL2L11 SMAD4 SMAD3 FOXO3 RUNX3 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer PPP2CA TNKS2 DKK1 PPP2CB DKK2 PPP2R1B DKK4 PPP2R1A AMER1 AXIN1 KREMEN1 CSNK1A1 KREMEN2 LRP5 LRP6 GSK3B CTBP2 CTBP1 CTNNB1 PPP2R5E FZD5 FZD4 WNT3A PPP2R5B PORCN PPP2R5A PPP2R5D FZD6 PPP2R5C APC FZD8 TCF7L2 RNF43 TNKS SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection POM121C NUP42 EZH2 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 TRIM28 NUP153 NUP93 NUP50 NUP35 NUP54 H3C8 HNRNPK H3C15 ELK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 DAXX H2BC1 NUP107 H2AC8 H2AC6 H2AC7 CEBPD DYNC1LI1 DYNC1LI2 EGFR NUP160 HDAC3 NUP85 H2BC26 CHMP1A H2BC21 EED TBL1X H2BC17 ITGB1 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 DYNLL1 H2BC11 CBX1 CHMP4C DYNLL2 CHMP4B NCOR1 TBL1XR1 CHMP3 CHMP4A CHMP6 RBBP4 CHMP7 RBBP7 DYNC1I2 PML NUP43 H2BC18 CHMP2B CHMP2A DYNC1I1 RANBP2 DYNC1H1 NUP37 NFKB1 H2AC17 H2AC12 NCOR2 H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 GPS2 TSG101 VPS4A MVB12B MVB12A VPS36 VPS37C VPS37D VPS37A H4C9 VPS37B SNF8 UBAP1 VPS25 VPS28 NUP205 POM121 H2AC20 NUP188 AAAS SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane MTMR14 PIK3C2G PIK3C2B INPPL1 SBF2 RUFY1 INPP4A INPP4B INPP5D PI4K2A INPP5J PIP4K2A PIP4K2B MTMR1 MTMR3 MTMR8 MTMR9 SYNJ1 MTMR6 MTM1 INPP5K PIP5K1A PIP5K1B PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PI4K2B MTMR2 RAB4A ARF1 PTPN13 RAB5A PTEN PIK3CD PIK3CB PIK3CG PIP5K1C SYNJ2 PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3R6 PIK3C2A PIK3R5 OCRL RAB14 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation RAD1 ATM AURKA RAD9B ATR PRKAG1 RAD9A PRKAG2 TP53RK STK11 UBA52 TAF7L CHEK2 PRKAG3 MDM2 MDM4 SUPT16H TBP CDK5 NUAK1 UBB TAF9 TPX2 CDK5R1 CCNA2 CCNA1 TAF1L UBC RPS27A TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 PLK3 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CDK2 MAPK14 MAPK11 MRE11 BRCA1 KAT5 TP53 EXO1 CHEK1 NBN TOPBP1 PIN1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 PRKAB2 TOP3A CSNK2A1 HUS1 CSNK2A2 PRKAB1 CSNK2B DNA2 RHNO1 BLM NOC2L WRN BRIP1 TP53INP1 PRKAA1 HIPK1 PRKAA2 RBBP8 ATRIP DYRK2 BARD1 HIPK2 RPA1 MAPKAPK5 RPA2 RAD50 RPA3 AURKB RAD17 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 TFRC HFE TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 STEAP3 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F MCOLN1 ATP6V1C2 ATP6V0A1 TF ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols CYP51A1 AHRR FDX1 FDXR FDX2 CYP8B1 ARNT CYP11B2 CYP46A1 CYP21A2 CYP39A1 ARNT2 CYP11B1 CYP11A1 NCOA1 CYP4V2 CYP1B1 NCOA2 POMC NR1H4 CYP7B1 CYP7A1 CYP27A1 RXRA CYP19A1 AHR G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 CDC6 CDC25A RBL2 RBL1 CDK1 MYC CCNA2 CCNA1 MAX TOP2A LIN54 PCNA LIN52 LIN37 HDAC1 LIN9 E2F1 DYRK1A E2F4 E2F5 TFDP1 RBBP4 CCNE2 TFDP2 CCNE1 CDK2 MYBL2 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases ELMO2 DOCK1 RASA1 UBA52 RAC1 SFPQ ARAP1 UBB UBC RPS27A CBL ELMO1 GPNMB LRRK2 PTK6 CDKN1B EREG BTC SOCS3 CCND1 HBEGF NRAS STAT3 HRAS NR3C1 EGF CDK4 CCNE1 CDK2 DOK1 CRK NRG2 NRG3 NRG4 EGFR PXN RHOA AKT1 ERBB2 NRG1 BCAR1 EPAS1 SRMS KHDRBS1 HIF1A KHDRBS2 KHDRBS3 STAP2 ARHGAP35 PELP1 PTPN1 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB ETV6 BIN2 KDR KANK1 GOLGA4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) DERL2 RNF139 UGGT2 OS9 UGGT1 MARCHF6 EDEM3 EDEM2 AMFR SEL1L SYVN1 RNF103 UBA52 TRIM13 MAN1B1 RNF5 RNF185 EDEM1 UBB UBC RPS27A DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers DKK1 DKK2 TFG DKK4 AMER1 RAC1 MDM2 KREMEN1 KREMEN2 LRP5 LRP6 VAV1 CEBPB SEC31A DERL2 MAPK9 MAPK8 OS9 RICTOR KLC1 NTRK2 STAT1 BDNF GAB1 FRS3 STAT3 MIB2 NTF4 NTF3 PLCG1 CD86 EGF CD80 AREG BCL2L1 EEF1G JAG2 JAG1 ADAM10 VCP CD19 DLL1 MIB1 SEL1L DLL4 NEURL1B ADAM17 NEURL1 PPFIBP1 HGF PRR5 GSK3B PIK3CD PIK3CB PIK3CG CTBP2 CTBP1 MLST8 PDPK1 PIK3CA LCK BCR ERLEC1 FYN CSK TCF7L2 PTPN11 MTOR TNRC6C PTPN6 IL10RA DNMT1 MCL1 PDGFRA NCBP1 NCBP2 PSENEN PSEN2 IL22 PSEN1 APH1A NCSTN APH1B HES5 PDGFB HEYL ETV6 FIP1L1 BIN2 KDR TP53 IL10 MYH9 RBPJ ATIC TNKS TNKS2 TPR PAPSS1 TYK2 GOLGB1 RRBP1 HEY1 DCTN1 HEY2 DUSP16 RPS6 FGFR1 EGFR TGFB1 BAD CASP9 NRG1 HHAT CLTC HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 DUSP10 PSMD3 PSMD1 DUSP8 DUSP9 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 PSMC1 FOXO6 FLT3LG PSMC2 FOXO4 FOXO1 RPS6KB2 HDAC4 MRAS SHOC2 ESR1 TENT4A KIAA1549 MPRIP TRIM24 PRF1 AGTRAP FOXM1 AP3B1 SND1 ICOS ZC3HC1 ESRP1 AKAP9 GSK3A KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 LMNA AGK QKI CLCN6 FAM131B AGGF1 IRF4 ALK PTEN EML4 PPM1B HIP1 PRKAR1A BCL11A EIF2AK3 STRN BIRC6 FN1 CCNC CCNB1 SRC CBL CTNNB1 MET TGFA ZMYM2 SHC1 YWHAB NRAS RAP1A MAPK1 HRAS SNW1 MAPK3 MAP2K1 MAP2K2 FRS2 BRAF SOS1 NRG2 NPM1 NRG3 NRG4 HDAC3 CSNK1A1 MAMLD1 TRIP11 CEP43 BCL2A1 EP300 TBL1X CREBBP NCOR1 TBL1XR1 GCC2 RHOG GOLGA4 FKBP1A CALM1 JUN KRAS MAML2 MAML1 FOXO3 BCL2L11 JUNB ERBIN NOTCH1 CARS1 RBX1 PPP1CB KIT RAC2 IHH HDAC1 MARK3 SHH DHH NCOR2 KAT2B KAT2A STAT5A STAT5B PIM1 NOX4 FZD5 GRB2 FZD4 WNT3A FGFR3 SYVN1 FZD6 FZD8 CDC37 KANK1 ITGA2B SPRED3 SPRED2 SPRED1 TGFBR1 TGFBR2 NF1 TSC2 AKT1S1 SPTBN1 MSN RB1 CDKN1A CDKN1B EREG BTC EPGN HBEGF APC SQSTM1 TPM4 TPM3 FLT3 PTPN12 PPP1CC PPP2R1B PPP2R1A CDK8 FGFR2 CLIP1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 PPP2R5E FGF22 GAB2 FGF16 FGF19 FGF18 HDAC5 PPP2R5B FGFR4 PPP2R5A HDAC2 FGF10 PPP2R5D PPP2R5C HDAC8 HDAC9 HDAC6 HDAC7 CUX1 FGFR1OP2 MYO18A CPSF6 PPP2CA PPP2CB GZMB HDAC10 HDAC11 RANBP2 TWIST1 RNF213 ATG7 PDGFRB TRAT1 NTRK3 PIK3AP1 WDR48 POLR2A SMAD2 POLR2B POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J ESR2 POLR2K POLR2L NR4A1 GTF2F1 GTF2F2 KIF5B AXIN1 CAMK2B CAMK2D CAMK2A LMO7 AKT2 MYC AKT3 AKT1 ERBB2 HES1 CAMK2G PHB1 ITGB3 ARAF MAPKAP1 PEBP1 ARRB1 PIK3R3 IQGAP1 PIK3R2 PORCN ARRB2 PIK3R1 RAP1B JAK2 PIK3R6 BRAP PIK3R5 FGB WDCP FGA LYN KSR1 VWF LRRFIP1 FGG KSR2 YES1 APBB1IP CNKSR2 CNKSR1 RAF1 ERLIN2 TLN1 MOV10 VCL ZAP70 AGO3 MAP3K11 AGO4 AGO1 RNF43 AGO2 BAG4 CD28 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP2 IGF2BP1 IGF2BP3 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors FSHB GPHB5 FSHR GNRH2 CGA GNRH1 TSHB TSHR LHCGR GNRHR2 LHB GNRHR GPHA2 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants KIT GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism PNPLA7 GDE1 GDPD1 GDPD3 GDPD5 ENPP6 PNPLA6 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription FCER2 NOTCH2 GZMB EP300 MAMLD1 RBPJ MAML2 MAML1 HES1 HES5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events RAPGEF1 CRK YWHAB CRKL RAP1A MAPK1 MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 BRAF NGF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle ARHGAP26 RHOC ARHGEF5 ACBD5 MACO1 VAMP3 C1QBP ARHGAP39 ARHGAP21 LMAN1 STX5 TFRC MCF2 MCAM ERBIN CCDC187 VANGL1 ARHGAP32 FMNL2 DIAPH3 VAPB ABCD3 TJP2 CAV1 VAV2 RTKN RHOA ARHGEF10L STK10 AKAP13 ROCK1 SLK LBR ROCK2 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 MYO9B FLOT1 CIT DAAM1 FLOT2 ARHGEF1 PKN3 IQGAP1 ARHGEF25 PIK3R1 ARHGEF28 ARHGAP1 IQGAP3 STOM FMNL3 ARHGAP5 ARHGAP35 PREX1 STARD13 OPHN1 JUP ARHGDIA CAVIN1 BCR MCF2L ANLN TMPO DIAPH1 ABR RACGAP1 DLC1 PKN2 PKN1 DEPDC1B ARHGAP18 ARHGEF40 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation ITGA2B FN1 SRC LAMTOR2 LAMTOR3 ITGB3 ARAF PEBP1 ARRB1 WDR83 IQGAP1 ARRB2 RAP1B YWHAB MARK3 FGB IL17RD NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A GALNS AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade F11 GP1BA PROS1 F5 F8 SERPINC1 F10 GP9 GP1BB SERPIND1 GP5 VWF F2 F9 PROC SERPINE2 SERPINA5 ANO6 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase CDC20 CDC14A ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 FZR1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A8 SLC30A1 SLC30A5 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6A TNRC6B PTEN MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation MAPK1 INS MAPK3 SOS1 IRS1 IRS2 SHC1 GRB10 INSR DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i ALG2 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle NISCH KCTD13 PKP4 EPHA2 MUC13 RND2 TFRC KTN1 VANGL1 BLTP3B GOLGA3 FNBP1 NUDC SCRIB PIK3R2 PIK3R1 ARHGAP1 TXNL1 ARHGAP5 KIF14 ARHGAP35 FRS3 DSG1 WDR6 PRAG1 PLXND1 FAM83B RBMX ANKRD26 DST KIDINS220 CAV1 FRS2 ALDH3A2 TNFAIP1 PTPN13 LEMD3 VANGL2 DEPDC1B UBXN11 LRRC1 CKAP4 DLG5 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin LEP STAT5A STAT3 STAT5B IRS1 IRS2 SOCS3 JAK2 PTPN11 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions EZH2 H2AX CDH4 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B H3C8 MTBP ZC3H12A CSNK2A3 H2AJ SRC CTNND1 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST H2AC8 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 RBBP7 H2AZ2 TGIF2 TNRC6C DOCK1 TNRC6A TNRC6B ARHGEF4 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 VAV2 PRDM8 BHLHE22 KDM1A CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 SNAI1 ZNF217 FURIN PCSK6 ANK3 TYK2 RB1 POMT2 DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 JAK2 H4C9 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAG YWHAZ YWHAE SFN CHEK2 CDC25C YWHAB WEE1 CCNB1 CHEK1 CDK1 YWHAH YWHAQ CCNA2 CCNA1 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle PTK6 CDK4 CDKN1B CCNE1 CDK2 CCND1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines TBK1 STAT6 STING1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking SERPINA1 PPP6C TFG PPP6R1 PRKAG1 PPP6R3 PRKAG2 TMED2 CTSC CD3G TRAPPC2L LMAN1L F5 F8 CD3D PRKAG3 SBF2 TRAPPC6A TBC1D20 RAC1 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TFRC TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 FTH1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 FTL SEC23IP CNIH1 KIF20A KLC1 CNIH2 KLC4 CNIH3 KLC3 FOLR1 KLC2 BET1 NEDD8 KIF11 KIF15 KIF23 EGF KIF22 AREG KIF26A TF COPS5 SCARB2 ITSN2 AGFG1 GAPVD1 BIN1 AMPH GRK3 CLTCL1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A YWHAG SYNJ2 TOR1B SNAP23 SYT9 SYT8 SNAP91 DAB2 AAK1 IL7R PICALM STON1 STON2 PIK3C2A SLC2A8 SGIP1 COL7A1 EPS15L1 PRKAA2 ARFGAP1 OCRL EPN1 EPN2 GAK CTTN ARF6 LRP2 FCHO1 FCHO2 RACGAP1 REPS2 UBQLN1 UBQLN2 HIP1R SNX18 NECAP2 NECAP1 CD4 SYT11 TRIP10 AP2A1 AP2A2 LDLRAP1 AP2M1 MAP1LC3B STXBP3 AP2S1 RAB27B LDLR CHRM2 GJA1 AP2B1 GJB2 ADRB2 MAN2A1 MYO5A ARPC1A WASL GNS MYH9 ARFGAP2 DVL2 KDELR1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 MYO1C CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SFN SNX5 TBC1D8B SNAPIN SORT1 DTNBP1 PUM1 TPD52L1 GOLGB1 YIPF6 ACBD3 SYNJ1 ALS2 GJC1 GJD2 MAN1A2 MAN1C1 GJA10 MAN1A1 CLINT1 DENND1C DENND1B GDI1 DENND5B DENND1A KDELR3 GDI2 RINL TRAPPC12 DCTN1 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 NSF DENND6A RIN1 RIN2 DENND3 RAB21 ALS2CL CHML GRIA1 ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB39B TRAPPC8 RAB12 EGFR RAB18 VPS45 RAB3GAP2 RAB3GAP1 MON1A MON1B FNBP1L FNBP1 CLTC CLTA UBA52 DCTN6 DCTN5 DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 UBB OPTN UBC RPS27A AP3B1 GALNT1 RAB27A KIFAP3 CSNK1D HIP1 KIF3B KIF3A TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 KIF3C VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 RAB3IP CHMP5 ARF4 AP1G1 ACTR1A AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 GALNT2 SH3GL3 SH3KBP1 STAM CBL RAB8A HGS EPS15 EXOC8 TGFA STAM2 SH3GL2 EXOC7 SH3GL1 RALA YWHAB AGPAT3 SBF1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 DCTN2 DCTN3 GBF1 RAB11A TRIP11 APOB C2CD5 ITSN1 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 ASPSCR1 RAB10 RAB14 GJB1 RAB13 USP6NL SCOC CFTR SYS1 GCC2 GCC1 RABEPK YWHAQ RAB43 GOLGA4 GOLGA1 ARFGAP3 ARFIP2 NAA30 COG8 COG7 COG6 COG5 COG4 INS COG3 CALM1 GJA3 COG2 RAB7A GJA5 COG1 YWHAE GJA4 VAMP3 APP NAA35 GJA9 NAA38 GJA8 VAMP4 GJC2 NAPA GJB4 NAPB GJB3 TMF1 GJB6 STX16 GJB5 RHOBTB3 GJB7 LMAN1 ARL1 GJD4 STX5 GOLGA2 NAPG GJD3 YKT6 STX10 TGOLN2 ARFRP1 VPS51 VPS53 VPS52 VTI1A YWHAH STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B RABGAP1 YWHAZ GABARAP GGA2 RABGEF1 GGA1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B WNT5A TBC1D2 PLIN3 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B PLA2G6 CHM ARF5 ARCN1 RAB5B RAB5C RAB5A CD55 GPS1 KDELR2 MYO6 FZD4 MIA2 COPS4 COPS2 GOSR1 ANK2 ANK3 ANK1 TSC2 TSC1 SPTBN4 SPTBN5 SPTA1 COPZ2 SPTBN1 COPZ1 SPTBN2 KIF4B KIF4A RAB41 SYT2 SYT1 EREG SPTAN1 SPTB BTC VAMP2 RAB30 EPGN DNM1 HBEGF RAB36 DNM3 ARF1 CTSZ AP4E1 CLTB BET1L AP4M1 AP1G2 BLOC1S1 SEC23A CLVS2 AP4S1 CLVS1 SAR1B TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 SEC24B DYNC1LI1 SEC24A DYNC1LI2 ZW10 SEC24D TMED3 SEC24C TMED7 SLC18A3 TMED9 RAB3A KIF18A SEC13 COPG2 COPG1 COPB2 COPA DYNLL1 COPB1 MAN2A2 TMEM115 DYNLL2 CHMP4C COPE KIF2A CHMP4B CHMP3 CHMP4A KIF2C CUX1 CHMP6 KIF2B CHMP7 PAFAH1B1 DYNC1I2 COPS7B COPS7A COPS3 COPS6 CHMP2B DYNC1I1 CHMP2A COPS8 DYNC1H1 CENPE AGTR1 LNPEP AVPR2 AVP TJP1 STX4 GOLIM4 TACR1 CAPZB CYTH3 CYTH2 GOLGA5 CYTH4 SNAP29 CYTH1 ALPP CAPZA1 CAPZA2 GRK2 KIF5C PLA2G4A KIF5B KIF5A KIF28P KIF12 USE1 AKT2 KIF19 KIF13B AKT3 KIF1C KIF21A AKT1 KIF1B KIF21B PRKAB2 KIF1A MIA3 KIF25 KIF6 PRKAB1 KIF27 RINT1 KIF9 KIFC2 KIF16B KIFC1 KIF20B NBAS ARRB1 STX18 BNIP1 ARRB2 SURF4 KIF18B KIF26B ARF3 MCFD2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 PPP2CA FLRT1 SPRED2 PPP2CB SPRED1 PPP2R1A SOS1 TGFBR3 UBA52 GIPC1 ANOS1 FGFRL1 FLRT3 UBB FGF1 FGF2 UBC FGF3 FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF22 MKNK1 FGF18 SPRY2 PIK3R1 PIK3CA FGF10 NRAS GAB1 MAPK1 FRS3 HRAS MAPK3 PLCG1 FRS2 BRAF PTPN11 FLRT2 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAG YWHAZ EP300 PDPK1 PSMC6 YWHAE SFN YWHAB SP1 UBE2I YWHAH CAV1 YWHAQ SMAD4 SMAD3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 VAC14 MTMR9 MTMR4 PIK3R4 PIK3C3 FIG4 PIKFYVE MTMR7 MTM1 PIK3C2A RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle ARHGAP12 ARHGAP26 RAB7A VAMP3 ARHGAP39 ARHGAP21 LMNB1 LMAN1 MCAM PLXNB1 MOSPD2 ADD3 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 STEAP3 CAPZB CAV1 ANKFY1 FILIP1 GOLGA8R LBR EFHD2 PGRMC2 PAK6 PAK5 CPNE8 WHAMM PIK3R2 PIK3R1 AKAP12 ARHGAP1 HINT2 ACTN1 SLC4A7 ARHGAP5 ARHGAP35 RHOD STBD1 PLXNA1 EMD DBN1 ARHGAP17 TMPO DIAPH1 RACGAP1 VRK2 LEMD3 DEPDC1B TOR1AIP1 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME ADH1A MAPDA NT5C2 ABCG2 SLC22A3 ABCB1 SLC22A2 SLC22A1 PCK1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK MAPK7 SOS1 MMP3 PRKCA HBEGF EGFR NRAS GAST RPS6KA3 RPS6KA2 MAPK1 HRAS RPS6KA1 MAPK3 CCKBR PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription CBFB RUNX3 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer TGFA EGF EREG BTC AREG EPGN HBEGF EGFR FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm SHH GATA4 IHH BMP4 FOXF1 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy VPS33A VPS33B VPS39 VPS18 TUFM VPS11 VPS16 VPS41 UVRAG MAP1LC3B VPS45 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling LCAT APOC2 ALB LIPG APOA1 APOE ABCG1 CETP APOC3 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 SZT2 SAMTOR SEH1L NPRL2 NPRL3 WDR59 RPTOR FLCN MIOS ITFG2 KPTN DEPDC5 WDR24 RRAGA SH3BP4 RRAGC FNIP1 RRAGB FNIP2 RRAGD KICS2 CASTOR1 CASTOR2 TCIRG1 SLC38A9 ATP6V1E1 RHEB ATP6V1E2 LAMTOR2 ATP6V0B LAMTOR1 ATP6V1G1 LAMTOR4 ATP6V0E1 LAMTOR3 ATP6V1G2 LAMTOR5 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MLST8 SEC13 SESN1 SESN2 MTOR OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions SEMA6A SEMA6D SEMA7A TYROBP ITGB1 PLXNA2 PTPRC PLXNB3 TREM2 SEMA4D SEMA3E ITGA1 SEMA4A PLXNA1 PLXND1 PLXNA4 CD72 SEMA5A PLXNC1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency ACAT1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System HLA-DRB3 SERPINA1 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 ASH2L CTSC CD3G MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 SEC22B TEAD3 H3-3B HLA-DPA1 TEAD4 H3C8 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 CD59 YAP1 GAB3 SEC31A DERL3 DERL1 RAP1GAP2 SIPA1 DERL2 TRBV12-3 H3C15 TRAPPC1 NOS3 PAK1 TRBV7-9 OS9 SPOP RICTOR HLA-DOA HLA-DOB PAK3 LAG3 PAK2 KIF20A BRD4 KLC1 SUZ12 H2BC9 KLC4 H2BC8 KLC3 H2BC5 KLC2 OSBPL1A STAT1 H2BC3 KIF11 STAT3 KIF15 CTSO MIB2 ACTR1B H2BC1 TRAV8-4 CTSH HLA-DPB1 CTSF FOSB CTSE KIF23 CD86 KIF22 TUSC3 HLA-DMA CD80 HLA-DMB TRAC RILP H2AB1 CD74 GRAP2 NEK2 KIF26A MAP3K8 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C PRKCE SEL1L TCF7 BTLA THEM4 TNFRSF14 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 MAP3K14 PRR5 GSK3B PIK3CD DPY30 STK10 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 LCK IRF1 STOM H2BC11 PRKAA1 PRKAA2 JUP LEF1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN DIAPH1 CSK RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 TNRC6A TNRC6B GPR84 ELOB ELOC ACAA1 SLC27A2 BIN2 ACTB FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 TP53 NF2 FBXL3 FBXL5 CCT2 SPHK1 TCP1 CDA ILF3 CCT8 TUBB4B NUP205 POM121 FNTA NUP188 FNTB IL1R1 AAAS POM121C NUP42 IFNAR1 NUP62 TPR CD79B NUP88 CD79A RAE1 KPNA1 IGHM NUP214 BLNK NDC1 NUP210 JAK3 NUP155 IFNGR1 NUP153 IFNGR2 NUP93 TYK2 NUP50 IGHD NUP35 NUP54 S1PR1 STAT2 PANX1 KPNA7 KPNA4 KPNA5 GSN KPNA2 KPNA3 KPNB1 COLEC12 TAX1BP1 TGFB1 EIF2AK2 CASP9 ISG15 CALR CLTC RPLP0 CLTA HSP90AA1 DNAJC3 CANX MTAP GBP1 ABCE1 HSPA1A BLK HLA-B VNN1 PDZD11 EEA1 TASL RBSN IRF5 PROS1 MRC1 CD33 HSPA5 SLC15A4 CD300A EIF4A3 THOC5 ALOX15 CD177 RAB27A IRF4 ATP8A1 CLEC10A CLEC4A CLEC4C CLEC4D SOX2 ATP11B CLEC4E ATP11A CLEC7A CLEC6A CARD9 PRKRA TARBP2 TRPM2 ATP8B4 TRPC1 ATP7A ANO6 LAMA5 FN1 VTN AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 PSME1 PSME2 APEH PSMB10 PSMB8 PSMB9 LPCAT1 UBE2D2 IGHV3-23 IGLV AGPAT2 IGLV2-8 IGKV1-16 IGKV1-17 PLD2 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DSC1 CDC34 PLA2G2A IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 PPL IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PI3 IGKV3-15 IGKV3-11 V2-8 V1-20 CEACAM1 ZEB1 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ASAH1 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 LAMP2 V1-5 V1-3 MT2A IGKV3D-20 V5-6 TRAF6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 CCR5 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CSF1 VAPA RPS6KA1 TNFSF11 YWHAZ ATG12 ATG5 RAC2 S100A9 S100A8 POMC FUCA1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 VAV3 IFNA17 SIKE1 MAVS IFNA10 RIGI NME2 VAV2 RAB5B IMPDH1 RAB5C GSTA2 IMPDH2 CA1 XDH FCGR3B HSP90AB1 ROCK1 ACTG1 BST1 RBBP6 OTUD5 VIM FURIN KCNAB2 CAB39 EIF4E LAMTOR2 LAMTOR1 ITGB5 LAMTOR3 EIF4G1 RAB3D RAB44 SNAP25 VAMP2 STX1A RAB37 ANXA1 RAB4B SEC23A PTPN12 SAR1B RAB24 SEC24B SEC24A MLEC MUC12 MUC13 SEC24D MUC15 SEC24C MUCL1 MUC3A MUC5AC MUC3B HMGB1 UBE2L3 CFP CASP8 CASP5 CASP4 CASP1 MUC1 RIPK3 IL18 MUC2 TRAF2 IL1A COPB1 IL1B IRF2 MUC7 PELI1 MUC4 MUC6 MUC16 MUC17 MUC19 BIRC2 PLAUR BIRC3 MUC5B PRKN MUC20 MUC21 SDCBP RIPK1 FADD ELANE GSDMD MGST1 ITCH STUB1 GSDME CPNE1 FPR2 CPNE3 HSPA9 UBE2B F2 SNAP29 PTAFR AHCYL1 NOS1 PRKACA ADA2 HP STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ITPR1 KNG1 ITPR2 ITPR3 CAMK2G MMP3 SURF4 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ITK FYB1 ZAP70 LCP2 TXN LAT CD101 MAP2K7 LAT2 MAP2K6 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 ARSA BTN3A2 BTNL2 IL6 CXCL8 MAPK9 MAPK8 MAPK7 IFNB1 MAPK10 TCN1 PLCG1 TNFSF13 BCL2 CD81 C4BPA BCL2L1 C4BPB CLU SERPING1 EEF1A1 CPB2 CFH C5AR2 C5AR1 CFI EEF2 C6 C7 ADAM10 C9 CD19 C8B C8A C8G ADAM17 CR2 CD46 CPN2 CPN1 CFHR2 NAPRT CFHR1 CFHR4 CFHR3 CFHR5 PDXK ALOX5 PTGS2 C3 C4A CD22 C5 C4B_2 CFB IL7R C2 SERPINB6 PLAU MGAM TXK CHIT1 EIF2S3 EIF2S2 EIF2S1 BECN1 CENPX MMP25 CEACAM6 CEACAM8 PRKCSH NOS2 ADAM8 CISH CSH1 PRLR GHR GOLGA7 GH2 SOCS2 MMP8 GH1 GBP6 CXADR LRRC7 IL10 OLR1 MYH9 TIFA CEACAM3 ALPK1 CD58 SIRPA JAML PCBP2 CD99 BST2 SELL CALM3 TREM1 CALM2 ARIH1 TXNIP HNRNPA2B1 IL17F IL17A PPIE GATA3 DDX3X SFN SIRPB1 DYNLT1 CD226 CD1D MMP9 CD1C CD1B cd21 CD1A KLRK1 SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 COL1A2 KIR2DS2 ATG14 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 HNRNPF SIGLEC9 NCR1 NCR2 CD200R1 NCR3 HCST LILRA6 LILRA1 LILRA2 LILRA3 CASP10 LILRA4 LILRA5 NCR3LG1 LAIR2 HSPA1B MICA LAIR1 MICB NPDC1 CLEC5A GLYCAM1 LILRB1 KIR3DL1 LILRB2 KIR3DL2 LILRB3 LILRB4 LILRB5 CD40LG EIF4G3 SIGLEC1 EIF4G2 SIGLEC8 EIF4E3 SIGLEC7 SIGLEC6 SIGLEC5 CD96 SNRPA1 OSCAR CEBPD CD8A KLRF1 CD300E CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM HLA-H HLA-C KLRD1 HLA-F ULBP1 ULBP3 PIANP HLA-G HLA-E KLRG1 CLEC2B FCGR2B CLEC2D TOMM70 IL17RC IL17RA TLR1 TLR6 PAG1 TLR2 PDIA3 UBE2D3 OAS2 RORC LTF GBP2 GBP4 FOXO1 SOCS3 SP100 PTPN18 IL37 PTPN20 NDUFC2 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 S100A1 CD36 FBXO32 IRAK3 TIRAP PIN1 PTEN ITGAL SRP14 TRIM63 APAF1 ITGA4 TNFRSF18 PRDX6 GSTP1 PTPN1 IL2RA CCL2 SLCO4C1 ATOX1 SOD1 PTPN4 LGALS3 SLC11A1 SMARCA4 PVR CTSV CTSL IL6ST CTSK PKM NECTIN2 NPM1 IFITM3 VEGFA IFITM1 IFITM2 FCER1A IFIT5 MS4A2 IFI35 IFIT1 IFI30 IFIT3 IFIT2 ICAM1 TRIM29 TRIM26 TRIM22 FAAP100 GBP5 GBP7 RSAD2 IFI27 TRIM17 PDE12 TRIM14 NLRP1 ATF6 TRIM10 EGR1 IRAK1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 RNASEL IFI6 FAAP24 FAAP20 IL2 PGGT1B IL3 FLNB HSPA1L IFI44L ILF2 MID1 IP6K2 VCAM1 FANCM FANCL FANCA HSPA2 FANCB FANCE FANCG FANCF CAT ISG20 XAF1 RETN FCGR1BP CIITA ADAR OASL TRIM68 TRIM62 OAS1 KRAS OAS3 IRF8 IRF6 EIF4E2 IRF9 SAMHD1 TRIM46 TRIM48 GBP3 SNCA TRIM45 HGSNAT MX2 JUNB MX1 TRIM35 RNF111 TRIM38 TRIM31 TRIM34 IST1 NEDD4L DHX58 TBC1D10C RNF125 RNF216 FRMPD3 GMFG ABCA13 PGLYRP1 NHLRC3 MCEMP1 RNASE3 CDK13 SCAMP1 RNASE2 UNC13D FLG2 GPI PADI2 CRACR2A PRDX4 S100A11 AZU1 PLA2G6 PA2G4 HRNR PIGR SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 PLEKHO2 SERPINB10 GRN SERPINB12 AGA ERP44 LRG1 YPEL5 GHDC TMEM179B EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A S100A7 BRI3 PTPRB NIT2 FCAR GM2A ACP3 RNASET2 TMBIM1 CANT1 FGL2 PRCP CPPED1 MNDA FOLR3 VPS35L CALML5 C6orf120 KRT1 SLPI CRISPLD2 TMEM63A WWP1 MMTAG2 SYNGR1 VAT1 PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 CYSTM1 PTPRJ GLIPR1 CAMP CD53 RAP2C FPR1 RAP2B CSF2 DNASE1L1 CSTB PGRMC1 CREG1 ORMDL3 GCA PTGES2 SVIP QPCT CD68 MPO COTL1 ENPP4 OSTF1 CD93 CCL11 IRAG2 ATAD3B DOK3 ADGRG3 DPP7 CCL19 ALDH3B1 GGH DNAJC13 TARM1 DEGS1 MS4A3 TNFAIP6 CCL22 CRISP3 HEBP2 CHI3L1 CCL20 CLEC12A MVP TMEM30A CMTM6 FKBP5 PDAP1 S100P PTX3 GLA CSF1R PSAP CXCL10 ABL1 CCL5 CCL4 CCL3 FANCC BCL6 CCR1 PPBP CCR6 CCR2 CR1 OPRD1 CXCR1 RNF34 CXCR2 NLRC4 CCL3L3 PML CXCL1 CXCL2 TWIST1 TAP2 TAP1 CD207 SEC61A2 MRC2 SEC61A1 SEC61G LIFR PTPN22 SEC61B KCTD6 TAPBP STX4 CAPZB SMAD3 SMURF2 CAPZA1 CAPZA2 SMURF1 TIMP2 TIMP1 SMAD7 SLC2A3 YBX1 CASP2 OPRM1 IFNG IQGAP1 RAP1B JAK2 FGB FGA PGLYRP4 PGLYRP3 FGG PGLYRP2 SLA2 SLA TNFRSF8 TNFRSF4 RAF1 REG3A REG3G VCL TNFRSF17 TNFRSF9 LTA4H KIR3DS1 LEAP2 TNFSF13B TNFRSF25 TNFRSF6B TNFSF18 TNFSF14 TNFSF15 TNFSF12 DAPP1 GNLY EDARADD EDAR LPO HSPA6 DCD LTA LTB F12 KLKB1 RNASE6 RNASE8 RNASE7 TNFRSF11B TNFRSF11A ERAP2 ERAP1 BPIFA1 BPIFA2 BPIFB1 TCIRG1 BPIFB4 BPIFB6 CD27 FTH1 TNFRSF13B ATP6V1E1 TNFRSF13C ATP6V1E2 EDA2R TNFRSF12A ATP6V0B ATP6V1G1 CD70 ATP6V0E1 EPPIN ATP6V1G2 EDA CHGA KIR2DS4 KIR2DS5 TNFSF6 ATP6V1B2 TNFSF4 ATP6V0D1 TNFSF9 TNFSF8 ATP6V0C ATP6V0D2 S100A7A FTL ITLN1 SIGLEC16 ATP6V1B1 SIGLEC15 ATP6V1A KLRC2 HTN1 HTN3 CAND1 LTBR ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 LCN2 ZBP1 TBK1 IRF3 NLRP4 DTX4 FCER1G AP2A1 CSF3 AP2A2 IL1RN TNF PRKACG IL12B IL12A IL10RB PRKACB IL1R2 IL10RA AP2M1 LIF MYLIP TNFRSF1B TNFRSF1A FCER2 NPC2 STXBP2 A1BG AP2S1 A2M HRG SERPINA3 ORM1 ORM2 AP2B1 QSOX1 AHSG P4HB IDH1 RAPGEF3 RAPGEF4 CD63 F13A1 CFL1 TALDO1 GNS PECAM1 AAMP DERA SDC1 PYGB PYGL MANBA GAA PGAM1 ALDOC ALDOA CD44 DBNL AGL GYG1 DCTN1 TKFC MAN2B1 HPSE B4GALT1 HK3 PGM2 PGM1 DEFB103B DEFB105B DEFB129 DEFB128 DEFB131A DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B DEFB108C DEFB130A DEFB130B DEFB4B GALNS PFKL LIMK1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE OPTN FLT3LG TNFAIP3 AMPD3 APRT CYLD PNP MAOA PPM1B EIF2AK3 PLPP5 PLPP4 PLD3 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CYB5R3 P2RX1 IL4 IL18RAP IL13 RAG2 RAG1 TSLP IL7 BRWD1 CRLF2 PLAC8 RHOA ICAM2 ICAM3 RELB RPS6KA5 CD209 ITGB1 CYFIP1 RAB10 RAB14 STBD1 RHOG ELMO2 DOCK2 DOCK1 NANOG RAB7A VAMP3 PLD1 IL34 IQGAP2 IL16 IFNLR1 IFNL1 TXLNA PTPRZ1 PRTN3 STX3 AOC1 DGAT1 FABP5 ITGAM ITGB2 ICAM4 ICAM5 ITGAX ITGB7 CD47 ITGAV ANXA2 PTK2 VASP CAP1 ENAH MYO9B CUL2 ABL2 NCK1 EVL SOS2 MMP2 NEU1 CTSA ELK1 SQSTM1 ARF1 CTSZ COMMD9 COMMD3 TXNDC5 HSPA8 DNM2 VAMP8 VAMP7 SOCS6 SOCS5 GSTO1 IRS1 PIK3R4 IRS2 FGF2 GAB2 TLR9 PIK3C3 IL9 IL9R CSF3R IL6R LRR1 CCNF KEAP1 CBLB UBE2L6 HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 TRIM21 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 ARMC8 UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 SIAH2 SIAH1 LNPEP MEX3C TRAT1 UBAC1 PIK3AP1 FBXL8 FBXL4 DZIP3 SH2B3 FBXL7 RNF220 DET1 TEC LRSAM1 SH3RF1 TRIM9 TRIM4 ARIH2 LRRC41 RNF144B GAN RNF138 RNF130 HUWE1 KLHL2 CST3 TTR UBE2G1 KLHL3 H2AZ1 UBE2G2 KLHL9 LYZ SPSB2 SPSB1 KBTBD6 KLHL5 TSPAN14 NEDD4 RLIM SEMG1 TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D ART1 FBXO27 DEFA1B LTN1 PRSS3 PRSS2 RNF19B UBE3A DEFA6 UBE3B DEFA4 FBXO21 DEFA5 UBE2Z DEFA3 FBXO22 NPEPPS RNF19A FBXW12 KIF5C ANPEP AREL1 FBXW8 KIF5B UBE2E3 KIF5A FBXO17 UBE4A FBXO15 MME UBE2E2 ATP6AP2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 CD180 FBXO44 LY86 FBXO41 LBP FBXO40 BPI SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 RNF182 UBA3 UBE2O TPP2 BLMH UBA1 UBE2K UBE2M TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 VHL TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 ASB3 ASB1 CHRNB4 HGF NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 IL1RAPL1 CYBB CYBA RACGAP1 NCKAP1L WASF1 WASF2 CKAP4 IL32 BAIAP2 CNTFR CNTF IL20RA ABI2 IL20RB IL22RA2 ABI1 IL31RA IL22RA1 TOLLIP C1QBP HAVCR2 CTF1 CLCF1 IL13RA2 IL13RA1 FSCN1 NDN MCL1 IL21R IL36A IL36B LGALS9 IL15RA SLC2A5 IL36G IL1F10 IL21 IL22 PSEN1 IL20 IL25 NCSTN IL26 IL24 IL11 IL15 IL19 HCK CD8B IL17RE OSMR ELMO1 IL17RB RHOU IL33 MAP3K3 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IFNL2 IL1RL2 PTK2B IFNL3 CYFIP2 WIPF1 WIPF2 WIPF3 C3AR1 ARHGAP9 BTK MEFV PLCG2 MYO5A ARPC1B ARPC1A WASL CTSG SYK WAS PYCARD IGHG3 IGHG4 IGHG1 IGHG2 NCKIPSD NLRP3 ARPC4 ARPC5 FAF2 ARPC2 ARPC3 PSTPIP1 FCGR3A ACTR3 RHOF ACTR2 FGR MYH2 FCGR1A WASF3 MYO10 P2RX7 FCGR2A MYO1C SUGT1 ARHGAP45 FRK IL2RG INPPL1 PLD4 INPP5D MOSPD2 HVCN1 GDI2 RAB31 RAB18 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ALAD PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 BCL10 RIPK2 DCTN5 PSMA7 MYD88 DCTN4 RELA MALT1 CAPZA3 PSMB6 ACTR10 PSMB7 PSMB4 PAFAH1B2 PSMB5 ATF1 UBB ECSIT PSMB2 PSMB3 NKIRAS1 UBC NKIRAS2 IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 IRAK4 SEM1 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 TLR10 PSMC3 RAP1GAP TLR5 PSMC4 LRRC14 PSMC1 PSMC2 USP14 NLRX1 PTPRC REL PELI3 NFKBIE PELI2 NFKBIB NLRC5 TREM2 NOD1 NOD2 AGER USP18 IRAK2 UBE2I S100A12 N4BP1 MAP3K1 RORA S100B TNIP2 SAA1 PIAS1 SUMO1 TYROBP MRE11 KIFAP3 KIF3B KIF3A KIF3C ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ACTR1A ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CEP290 SH3KBP1 SRC CBL CDH1 CTNNB1 SH3GL2 RALA TUBB SHC1 YWHAB CRKL NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 DCTN2 SOS1 CRK DCTN3 ARG1 ATF2 LY96 HBB CRCP HMOX1 EP300 APOB POLR3GL POLR3A POLR3B POLR3C CREBBP POLR3D POLR1C MEF2C POLR3E POLR3F POLR1D POLR3G POLR3H POLR3K TLR4 NFE2L2 PPP3CA PPP3CB PPIA RASGRP1 RASGRP3 PPP3R1 NFATC3 NFATC2 NFATC1 FKBP1A CALM1 APP JUN FASLG SOD2 FOXO3 LMNB1 BCL2L11 CAPN1 RAB6A IGF2R SLC44A2 RAB9B RBX1 ADGRE5 ADGRE3 DUS2 FLNA CD55 STAT5A STAT5B PIM1 GRB2 POU2F1 CTSD CUL3 KBTBD7 HEXB SPTBN2 MSN KIF4B GLB1 KIF4A GUSB ARSB CDKN1A SPTAN1 CDKN1B FZR1 DNM1 DNM3 CCND1 SKP2 NCAM1 NFASC CDK4 FLT3 NUP107 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 NUP160 DSN1 NUP85 RAB3A KIF18A PPP2R5E SEC13 NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DNAJC5 DYNLL1 DYNLL2 KIF2A BIRC5 KIF2C KIF2B DYNC1I2 PPP2CA PPP2CB NUP43 DYNC1I1 RANBP2 DYNC1H1 CENPE CENPS NUP37 PRL EIF4A2 EIF4A1 DSP CASP3 DSG1 ACLY PKP1 POLR2E POLR2F POLR2H POLR2K POLR2L PRKCD H2AC19 H2AC14 H2BC12L UNC93B1 AKT2 TLR8 TLR7 MYC AKT3 FUCA2 TLR3 TRBC1 BPIFB2 CTSS AKT1 LGMN ICOSLG CTSB PRKAB2 HSP90B1 FCN1 CSNK2A1 FCN2 CSNK2A2 PRKAB1 FCN3 CSNK2B MASP1 TRIB3 CFD ATF3 MBL2 CRP RPN2 EPAS1 C1QB C1QA MAPKAP1 COLEC11 RPN1 COLEC10 PIK3R3 C1S PIK3R2 C1R PIK3R1 GZMM HIF1A C1QC PIK3R6 PIK3R5 GRB10 TRAV29DV5 HLA-DQA2 CGAS LYN DDX41 WWTR1 LRRFIP1 HLA-DRB5 AIM2 YES1 IRF7 TRIM56 H4C9 HLA-DRB4 PRKDC DHX9 JUND NLRC3 ERLIN1 ERLIN2 IFI16 MOV10 DHX36 AGO3 STAT6 AGO4 XRCC6 XRCC5 H2AC20 AGO1 TREX1 AGO2 STING1 CD28 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 SSB GTF3C2 NFIX GTF3C3 NFIA CRCP NFIB GTF3C4 NFIC GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells PRKCB CBFB RUNX1 LGALS3 CREBBP CSF2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system HLA-DRB3 TNFRSF6B HLA-DRB1 TNFSF18 TNFSF14 TNFSF15 TNFSF12 UBE2M EDARADD EDAR LTA LTB IL6 JAK1 TNFRSF11B TNFRSF11A CXCL8 HLA-DPA1 H3C8 FOS VAV1 CD27 TNFRSF13B HLA-DQB2 TNFRSF13C RNF7 HLA-DQB1 EDA2R TNFRSF12A GAB3 CD70 EDA MAPK9 H3C15 MAPK8 MAPK7 TNFSF6 TNFSF4 TNFSF9 TNFSF8 PAK2 IFNB1 MAPK10 STAT1 LTBR STAT3 HLA-DPB1 PLCG1 TNFSF13 CD86 BCL2 CD80 BCL2L1 GRAP2 MAP3K8 LCN2 TBK1 IRF3 ADAM17 TNFRSF14 NFKB2 HLA-DRA MAP3K14 HGF PIK3CD PIK3CB ALOX5 PTGS2 IL1RAPL1 IL7R PIK3CA LCK IRF1 CDC42 FYN CSK PTPN11 IL32 CD4 PTPN6 CNTFR CNTF EIF2S3 IL20RA IL20RB CSF3 IL22RA2 IL1RN EIF2S2 IL31RA TNF EIF2S1 IL22RA1 IL12B TOLLIP IL12A HAVCR2 IL10RB ELOB CTF1 IL1R2 IL10RA CLCF1 BECN1 ELOC IL13RA2 LIF IL13RA1 TNFRSF1B FSCN1 TNFRSF1A FCER2 NDN MCL1 IL21R IL36A IL36B LGALS9 CENPX IL15RA IL36G IL1F10 IL21 IL22 IL20 IL25 IL26 STXBP2 IL24 IL11 IL15 IL19 HCK IL17RE OSMR IL17RB RHOU IL33 MAP3K3 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IFNL2 ACTB IL1RL2 PTK2B P4HB IFNL3 NOS2 CISH CSH1 PRLR GHR PLCG2 GH2 F13A1 SOCS2 GH1 GBP6 CFL1 CTSG SYK TP53 TALDO1 IGHG4 IGHG1 IL10 SPHK1 TIFA TCP1 ALPK1 SDC1 BST2 ILF3 FCGR1A ARIH1 NUP205 HNRNPA2B1 POM121 IL17F FNTA IL17A NUP188 FNTB AAAS IL1R1 POM121C NUP42 IFNAR1 NUP62 GATA3 TPR CD44 NUP88 RAE1 KPNA1 NUP214 SFN NDC1 BLNK NUP210 IL2RG JAK3 INPPL1 NUP155 IFNGR1 IFNGR2 NUP153 MMP9 NUP93 INPP5D TYK2 NUP50 NUP35 NUP54 S1PR1 STAT2 COL1A2 HNRNPF HSPA1B KPNA7 KPNA4 KPNA5 EIF4G3 CD40LG KPNA2 EIF4G2 KPNA3 EIF4E3 SNRPA1 CEBPD KPNB1 HLA-H HLA-C HLA-F HLA-G TGFB1 HLA-E EIF2AK2 ISG15 IL17RC IL17RA RPLP0 HSP90AA1 UBE2D3 DNAJC3 PSMD8 RORC OAS2 IKBKB CANX PSMD6 GBP2 PSMD7 GBP4 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 MTAP PSMA6 PSMA3 GBP1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 ABCE1 HSPA1A PSMD14 PSMD13 CUL1 RIPK2 HLA-B PSMA7 MYD88 RELA PSMB6 PSMB7 PSMB4 PSMB5 TRAF3 ATF1 UBB PSMB2 PSMB3 NKIRAS1 NKIRAS2 UBC IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 SEM1 IRAK4 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 IRF5 LRRC14 PSMC1 FLT3LG PSMC2 USP14 NLRX1 FOXO1 PELI3 PELI2 NFKBIB SOCS3 NLRC5 NOD1 HSPA5 NOD2 AGER EIF4A3 USP18 SP100 IRAK2 S100A12 UBE2I N4BP1 RORA S100B TNIP2 THOC5 SAA1 ALOX15 PTPN18 IL37 PIAS1 PTPN20 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR SUMO1 PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 CD36 IRAK3 IRF4 PIN1 MAOA PPM1B SOX2 EIF2AK3 TNFRSF18 PRKRA TARBP2 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB CSF2RA PTPN1 IL5 IL2RB IL3RA CCL2 IL2RA LAMA5 SOD1 PTPN4 FN1 UBE2E1 UBE2D1 HLA-A B2M CDK1 SRC CBL PSME2 PSMB8 RALA SHC1 UBE2D2 CRKL NRAS MAPK1 HRAS SMARCA4 MAPK3 MAP2K1 IL4 IL18RAP MAPK14 IL13 IL6ST MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 RAG2 CRK RAG1 UBE2V1 TSLP IL7 BRWD1 CRLF2 NPM1 IFITM3 ATF2 IFITM1 VEGFA IFITM2 IFIT5 IFI35 IFIT1 IFI30 IFIT3 IFIT2 ICAM1 TRIM29 ZEB1 TRIM26 TRIM22 FAAP100 GBP5 GBP7 RSAD2 IFI27 RELB RPS6KA5 TRIM17 HMOX1 PDE12 UBE2N TRIM14 TAB3 ATF6 TAB2 TRIM10 TAB1 ITGB1 EGR1 IRAK1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 RNASEL MEF2C IFI6 FAAP24 FAAP20 IL2 PGGT1B IL3 FLNB HSPA1L IFI44L ILF2 MID1 IP6K2 MT2A VCAM1 FANCM FANCL TRAF6 FANCA IGHE HSPA2 FANCB FANCE PPIA FANCG FANCF ISG20 XAF1 FCGR1BP CIITA ADAR CCR5 OASL NANOG TRIM68 TRIM62 APP OAS1 JUN OAS3 KRAS FASLG IRF8 IRF6 SOD2 EIF4E2 FOXO3 IL34 IRF9 IL16 SAMHD1 CSF1 TRIM46 IFNLR1 TRIM48 LMNB1 IFNL1 TXLNA GBP3 PTPRZ1 SNCA BCL2L11 TRIM45 PRTN3 JUNB STX3 MX2 RPS6KA1 MX1 TRIM35 TNFSF11 TRIM38 TRIM31 TRIM34 RBX1 YWHAZ POMC ITGAM ITGB2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 ITGAX TRIM25 IFNA21 DUS2 IFNA14 IFNA16 IFNA17 ANXA2 MAVS IFNA10 RIGI FLNA GSTA2 CA1 STAT5A STAT5B ACTG1 PIM1 ABL2 GRB2 NCK1 POU2F1 SOS2 VIM PTPRJ FPR1 CSF2 MMP2 FURIN CCL11 CCL19 EIF4E CCL22 MSN CCL20 EIF4G1 FKBP5 SNAP25 CSF1R ELK1 CDKN1A CDKN1B CXCL10 VAMP2 STX1A CCND1 ANXA1 SQSTM1 CCL5 ARF1 CCL4 CCL3 NCAM1 FLT3 PTPN12 NUP107 HSPA8 FANCC PPP2R1B VAMP7 PPP2R1A SOCS6 SOCS5 BCL6 GSTO1 CCR1 NUP160 IRS1 NUP85 IRS2 FGF2 CCR2 HMGB1 CASP8 GAB2 OPRD1 SEC13 CASP1 NUP133 MUC1 PPP2R5A IL18 IL9 PPP2R5D TRAF2 IL9R IL1A IL1B IRF2 PELI1 BIRC5 CSF3R BIRC2 IL6R CCL3L3 BIRC3 PML GSDMD UBE2L6 PPP2CA HERC5 PPP2CB NUP43 CXCL1 CXCL2 RANBP2 TRIM21 TWIST1 CENPS NUP37 PRL SH2B3 HSPA9 TEC EIF4A2 EIF4A1 LIFR CASP3 STX4 PTAFR NEDD4 SMAD3 CAPZA1 TIMP1 SMAD7 PRKACA PRKCD YBX1 OPRM1 CAMK2B CAMK2D CAMK2A IFNG AKT2 MYC AKT3 AKT1 HSP90B1 CAMK2G CUL5 UBA7 MMP3 PIK3R3 LBP PIK3R2 PIK3R1 HIF1A RAP1B SOCS1 JAK2 GRB10 HLA-DQA2 LYN RPS6KA3 RPS6KA2 HLA-DRB5 MAP2K3 YES1 IRF7 SLA2 MAP2K4 HLA-DRB4 SLA TNFRSF8 DHX9 TNFRSF4 RAF1 STAT6 TNFRSF17 TNFRSF9 MAP2K7 MAP2K6 TNFSF13B TNFRSF25 UBA3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling HRAS TGFA SOS1 EGF EREG BTC AREG EPGN SHC1 HBEGF EGFR NRAS PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 TPTE2 RUFY1 INPP4A INPP4B PI4K2A VAC14 MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 GDPD3 TPTE GDPD5 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 AGPAT5 FIG4 PLA2G1B LPCAT1 PIKFYVE PLA2G5 PI4KB PNPLA6 PLD6 AGPAT1 PI4K2B AGPAT2 MTMR2 LCLAT1 SACM1L AGPAT3 PI4KA AGPAT4 SBF1 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 PLA2G4B PLA2G2A DDHD2 DDHD1 GNPAT LPCAT4 PLA2G10 GPD1 GPD1L PLA2R1 PIK3CD PIK3CB PIK3CG PIP5K1C SYNJ2 INPP5E PIK3CA PIK3C2A OCRL RAB14 ALPI PITPNB TAFAZZIN AWAT2 PLD1 PIP4K2A PIP4K2B SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPAT2 DGAT2 DGAT1 RAB4A GPD2 LPIN1 STARD7 LPIN2 MGLL LPIN3 PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PIP4P1 PNPLA8 PLA2G4C MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 RAB5A INPPL1 PLD4 INPP5D INPP5J SYNJ1 ARF1 HADHB HADHA ABHD3 PCTP CEPT1 MFSD2A PCYT1B CHKB PCYT1A CHKA STARD10 PHOSPHO1 PEMT CHPT1 GPAM ACHE PIK3R4 BCHE CHAT PIK3C3 PNPLA2 LPGAT1 CPNE7 CPNE6 CPNE1 CPNE3 PCYT2 PISD PLA2G15 PGP PLA1A ABHD4 PGS1 PTPMT1 OSBPL8 OSBPL5 DGAT2L6 CRLS1 CDS2 OSBPL10 PLAAT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 PTDSS2 SELENOI PTDSS1 MBOAT1 ETNPPL ETNK2 ETNK1 PNPLA3 MBOAT7 PTPN13 CDS1 PITPNM1 PITPNM3 PITPNM2 AGK CDIPT PLA2G4A PTEN MTMR4 CSNK2A1 CSNK2A2 PLD3 CSNK2B PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 ARF3 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins MGAT2 MOGS B4GALT1 ALG14 MAN1B1 ALG13 DPAGT1 ALG8 NEU1 ALG9 ALG6 ALG2 ALG3 CTSA ALG12 ALG1 ALG11 MPDU1 RFT1 GLB1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane ARL2BP SLC25A5 SLC25A4 SLC29A3 SLC25A6 SLC28A2 SLC29A1 SLC29A2 SLC28A3 ARL2 SLC29A4 SLC28A1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth COL9A2 COL6A5 SPTBN4 SPTBN5 NCAN SPTA1 ST8SIA4 SPTBN1 SPTBN2 ST8SIA2 AGRN CNTN2 CACNA1H CACNA1G CACNA1I SPTAN1 PTPRA SPTB NRAS MAPK1 HRAS NCAM1 MAPK3 ARTN GFRA2 CACNA1D GFRA4 NRTN SOS1 CACNA1S PRNP PTK2 PSPN CACNA1C GFRA1 RPS6KA5 GDNF CACNB1 CACNB2 CACNB3 CACNB4 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 FYN COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle CDC42EP1 GIT2 WWP2 ARHGAP26 TRIP10 RAB7A OBSCN VAMP3 ARHGEF7 ARHGAP33 ARHGAP21 SRGAP2 PAK4 TFRC GFOD1 SLC1A5 MPP7 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 PAK1 PAK2 STEAP3 GJA1 CAV1 CDC42EP4 CDC42EP3 CDC42EP2 WASL GOPC ARHGEF9 ARL13B CPNE8 SNAP23 FNBP1 SCRIB SYDE1 IQGAP1 CDC42BPB ITSN1 CDC42BPA ARHGAP1 GIT1 IQGAP3 SLC4A7 STOM ARHGAP5 ARHGAP35 PREX1 OPHN1 JUP CDC42 CFTR ARHGAP17 PLEKHG3 DLC1 DEPDC1B THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP2B CHMP2A PIK3C3 BECN1 UVRAG MAP1LC3B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PIK3R4 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CASP3 CASP7 CYCS XIAP CASP9 DIABLO APAF1 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins POM121C NUP42 PHC2 NUP62 NUP43 TPR PHC1 CBX4 NUP88 CBX2 HERC2 RAE1 CETN2 NUP214 RANBP2 PHC3 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 BMI1 RING1 SMC5 SMC6 NUP37 NSMCE3 RNF2 NSMCE2 NSMCE1 EID3 CDKN2A PIAS4 NSMCE4A SP100 UBE2I PIAS1 NUP107 SUMO1 SMC3 SUMO3 SUMO2 RNF168 BRCA1 RAD52 NUP160 NUP85 RAD21 XRCC4 STAG1 STAG2 MDC1 TDG BLM SEC13 NUP133 WRN PCGF2 SMC1A PARP1 HDAC7 RPA1 NUP205 POM121 NUP188 XPC AAAS CBX8 PML SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells NANOS3 TET2 CBFA2T2 PDPN NANOG PRDM1 POU5F1 TFAP2C EOMES CXCR4 SOX17 BMP4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor INS TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B IDE ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 FLT3LG ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 NRAS GAB1 ATP6V0A2 MAPK1 HRAS ATP6V1H ATP6V0A4 ATP6V0E2 MAPK3 ATP6V1G3 ATP6V1D ATP6V1C1 FRS2 ATP6V1F FLT3 ATP6V1C2 ATP6V0A1 SOS1 THEM4 PTPRF KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 TRIB3 FGF23 PDPK1 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 PIK3R2 PIK3CA PIK3R1 FGFR4 FGF10 GRB10 INSR CTSD PTPN1 PTPN11 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants FLT3 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids MTMR10 CYP2C19 CYP3A4 TNFAIP8 MTMR12 MTMR14 GDE1 PRKAG2 PIK3C2G CYP2C9 PIK3C2B CSNK1G2 TNFAIP8L1 STS TNFAIP8L3 CYP2C8 TNFAIP8L2 ENPP6 ARSA SBF2 CYP2D6 TPTE2 RUFY1 CYP1A2 INPP4A CYP1A1 INPP4B PI4K2A SUMF2 AHRR CYP2E1 SUMF1 VAC14 MTMR1 HPGDS MTMR3 MTMR8 GDPD1 MTMR9 GSTM4 GDPD3 CYP24A1 TPTE GDPD5 MTMR6 MTMR7 ARSL MTM1 INPP5F ARSJ INPP5K PIP5K1A ARSK PIP5K1B ARSH PLEKHA1 ARSI PNPLA7 PLEKHA2 ARSF PLEKHA5 PLEKHA6 ARSG PLEKHA3 PLEKHA4 BMX ARSD PLEKHA8 FIG4 ABCG2 PIKFYVE PI4KB PNPLA6 OSBPL1A ACOT9 ACOT7 ACOT1 FAR1 FAR2 MCAT PRXL2B ACOT7L PTGR2 PTGS1 G0S2 THEM5 CYP19A1 FHL2 FADS2 FAAH2 FADS1 TNFRSF21 HSD17B13 AWAT1 SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 CPT1B PTGES ALOX15B THEM4 HILPDA ANKRD1 CBR1 FITM1 FITM2 GRHL1 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 ACSF2 DBI PIK3CD CPT2 PON3 PIK3CB PON2 PIK3CG PON1 PIP5K1C ALOX5 PTGS2 SYNJ2 PIK3CA PIK3C2A CYP2R1 PRKAA2 OCRL LRP2 GPX4 ALOX12B ALOXE3 ALPI TIAM2 PRKACG LDLRAP1 PRKACB CUBN APOA2 APOA5 ACOT8 EHHADH HSD17B4 ANGPTL4 ACAA1 PECR DECR2 ABCD1 SLC27A2 ACOT4 CROT SCP2 NUDT19 PHYH IDI2 MSMO1 HSD17B7 ACAT2 NSDHL BAAT STARD5 ARV1 ABCA1 SLC10A1 EBP ACOX2 DHCR24 SLC10A2 NR1H3 SLC51A PLPP6 AGPS SLC51B ACOT2 SLC27A5 LTC4S ACOX3 GBA1 HACL1 ALB HAO2 EPHX2 NUDT7 AMACR STARD7 CRAT ST3GAL2 ST3GAL3 MED19 MED18 MED11 MED29 MED28 MED22 MED21 SPHK1 GGT1 DPEP2 DPEP1 AKR1B1 GGT5 MED13L ACBD5 PPARGC1B INPPL1 PLD4 INPP5D INPP5J SYNJ1 MED9 CDK19 ECI1 ACADM DECR1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 UGT1A9 FUT2 FUT1 PTGDS MED27 MED26 MED23 MED25 B3GALT4 MED24 MED20 ABHD3 PCTP CEPT1 ABCB4 MFSD2A PCYT1B CHKB PPARD SLCO1B1 SLCO1B3 PCYT1A CHKA STARD10 PHOSPHO1 PEMT CHPT1 CYB5B KPNB1 SMPD3 ABCB11 ACSL1 SMPD2 PEX11A CIDEC B4GALT6 ELOVL5 B4GALT5 ST6GALNAC6 THRSP PNPLA2 HSD3B7 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP7A1 CYP27A1 ALOX12 ALAS1 SULT2A1 RAN FASN RGL1 MED30 ELOVL3 PIAS4 CIDEA MED31 UBE2I VDR NR1H2 RORA ABCC1 ALOX15 CYP4F3 CPT1A CYP4A22 CYP4B1 CYP4F22 CYP4F11 PTPN13 CYP4F8 PTGR1 RXRA SCD5 SMPD1 ALOX5AP SUMO2 PPARG PPARA CDS1 CD36 PITPNM1 PITPNM3 AGK PITPNM2 CDIPT AKR1C3 ACOXL PTEN MECR PLD3 ARNT CYP46A1 CYP39A1 CYP27B1 CYP11B1 ME1 ABCC3 GPX1 SLC27A1 CCNC B3GNT5 AGPAT5 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 PI4K2B AGPAT2 MTMR2 LCLAT1 SACM1L AGPAT3 PI4KA AGPAT4 SBF1 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 SREBF1 PLA2G4B PLA2G2A DDHD2 MAPKAPK2 DDHD1 GNPAT LPCAT4 RXRB PLA2G10 GPD1 GPD1L PLA2R1 HDAC3 SMARCD3 CHD9 NPAS2 HELZ2 ASAH1 TGS1 DHRS7B EP300 INPP5E TBL1X PPARGC1A SLC25A17 NCOA1 CYP11A1 MED1 GC NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 RAB14 TBL1XR1 PLIN2 CARM1 BMAL1 CLOCK SRD5A2 SRD5A1 CYP17A1 PITPNB TAFAZZIN AWAT2 PLD1 PIP4K2A PIP4K2B VAPA MED8 SLC44A5 MED4 MED6 SLC44A3 PTGIS MED7 TBXAS1 VAPB SLC44A4 SLC44A1 MOGAT3 SLC44A2 CYP8B1 STARD3 MOGAT2 STARD4 MOGAT1 ABHD5 STAR STARD6 FABP12 STARD3NL GK3 TSPO GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 ECHS1 GK DGAT1 ACSM3 FABP9 ACSM6 PPP1CA HADH FABP1 ACADS POMC FABP2 FABP3 RAB4A FABP4 FABP5 FABP6 FABP7 GPD2 PLIN3 CAV1 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 MGLL LPIN3 PLA2G3 PLA2G6 PLB1 CGA PLA2G4F TMEM86B PLA2G4E PIP4P1 PNPLA8 PLA2G4C MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 THRAP3 FAM120B NCOR2 RAB5A GPS2 GM2A HSD3B2 CYP11B2 CYP21A2 HSD3B1 CYP2U1 CYP4F2 CYP4A11 CYP1B1 NDUFAB1 NCOA3 GLIPR1 PTGES3 HSD17B1 ORMDL3 PTGES2 ST6GALNAC5 NEU2 NEU3 HEXB NEU1 ALDH3B1 HEXA ST8SIA5 ST3GAL5 GLB1L3 CTSA DEGS1 GLB1L2 GLB1L GLB1 SRD5A3 ARSB GLA PSAP TM7SF2 GGPS1 ARF1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A ACADVL MVK INSIG2 ESRRA SAR1B INSIG1 M6PR ACACB ACACA HADHB PPP1CC PMVK HADHA SCAP SC5D ACADL FDFT1 CDK8 FDPS LHB MBTPS1 SEC24B SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD ACHE SP1 DHCR7 SEC24D ACBD4 HSD11B1 SEC24C HSD11B2 MBTPS2 SERPINA6 PIK3R4 SIN3A BCHE CERK LBR GBA3 GBA2 OSBP GPX2 MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 CHAT PIK3C3 UGCG UGT8 ALDH3B2 SGPL1 B4GALNT1 KDSR TSPOAP1 B3GALNT1 ACER2 FA2H ACER1 ACER3 DEGS2 GAL3ST1 SPTLC1 SMPD4 SPTLC2 SLCO1A2 SPTLC3 A4GALT CERS3 CERS4 TXNRD1 CERS5 CERS6 SPHK2 CERS1 CERS2 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB SPTSSA ORMDL1 HMGCL ACSS3 SGPP2 BDH2 SGPP1 BDH1 SLC22A5 GALC CH25H OXCT1 OSBPL9 OXCT2 OSBPL7 HMGCS2 OSBPL6 HMGCLL1 AACS OSBPL3 ACAT1 OSBPL2 LPGAT1 CPNE7 AKR1B15 HSD17B14 CPNE6 HSD17B11 CPNE1 CPNE3 HSD17B2 PCYT2 PISD PLA2G15 PGP HACD1 PLA1A ABHD4 TECR PGS1 HSD17B3 PTPMT1 HSD17B12 HACD3 OSBPL8 HACD2 OSBPL5 HSD17B8 DGAT2L6 HACD4 CRLS1 HTD2 CDS2 OSBPL10 MORC2 PLAAT1 CBR4 ELOVL1 PLAAT2 ARNT2 OLAH GPCPD1 ELOVL4 PLAAT5 ELOVL2 PLAAT4 ACSL6 PTDSS2 SELENOI MBOAT1 ACSL5 PTDSS1 ACSL4 ETNPPL ELOVL7 ETNK2 ETNK1 ACSL3 TECRL PNPLA3 ACSF3 ACLY PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 MBOAT7 AGT PRKACA PLA2G4A FDX1 FDXR FDX2 MTMR4 LGMN PRKAB2 CSNK2A1 CSNK2A2 CSNK2B TRIB3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 MCEE PIK3R5 PCCA MMAA PCCB MMUT HPGD LTA4H CYP2J2 NRF1 ARF3 AHR SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants HRAS KRAS NRAS SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions BSG SLCO2B1 SLCO2A1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A10 SLC22A12 SLC17A5 SLC25A1 SLC13A2 SLC13A3 SLC16A1 SLCO1C1 SLC44A5 SLC5A12 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC13A5 SLC5A8 AVP SLC22A6 SLC16A7 SLC16A8 EMB SLC16A3 SLC22A11 SLCO1A2 SLCO4A1 SLC22A8 SLCO4C1 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 CYP17A1 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation LTF DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o DPM1 DPM2 DPM3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes MCRS1 KMT2A ASH2L KMT2C PHF20 MEN1 OGT KAT2B KAT2A KAT8 PAXIP1 HCFC2 WDR82 BOD1L1 DPY30 MBIP TASP1 KAT14 KMT2D DR1 BOD1 WDR5 TADA2A ZZZ3 HCFC1 YEATS2 TADA3 KMT2B AKAP8L SGF29 PHF20L1 KANSL1 KANSL2 KANSL3 NCOA6 PAGR1 CXXC1 SETD1B SETD1A KDM6A RBBP5 PSIP1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism NT5C ITPA NUDT16 NT5C1A ADPRM NUDT5 GDA DNPH1 NT5C2 NT5E NUDT15 XDH PNP NT5C1B REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NEUROD1 NKX2-2 PAX4 INSM1 NEUROG3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 FOS ATF1 UBB ECSIT NKIRAS1 NKIRAS2 UBC IKBIP MEF2A RPS27A DUSP4 DUSP3 NFKB1 IRAK4 VRK3 MAPK9 NFKBIA DUSP6 MAPK8 DUSP7 MAPK7 TLR10 TLR5 LRRC14 ELK1 USP14 NLRX1 PELI3 PELI2 NFKBIB NLRC5 MAPK10 NOD1 NOD2 AGER USP18 IRAK2 MAPK1 S100A12 N4BP1 MAP3K1 MAPK3 S100B TNIP2 MAP2K1 SAA1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 TP53 ATF2 NFKB2 HMGB1 RPS6KA5 CASP8 UBE2N TIFA TAB3 ALPK1 TAB2 TAB1 IRAK1 PPP2R5D MEF2C TRAF2 RPS6KA3 PELI1 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k ALG1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle CSKMT SDHC SDHD SDHA SDHB SDHAF2 IDH2 SDHAF3 ACAT1 SDHAF1 SDHAF4 ISCA2 ISCA1 CS LYRM4 ACO2 SIRT3 FXN DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication DNAJB11 HDLBP NMT1 DPM1 DPM2 RTN3 DPM3 KPNA1 MAGT1 UBA52 SUN2 HSPA1A MAP1LC3B RRBP1 UBB EIF4E UBC BTF3 RPS27A EIF4G1 NPLOC4 FASN EIF4A2 EIF4A1 HSPA5 EIF4A3 ACOT2 HSPA1B UBE2I IPO7 P4HB KPNA7 BAG2 TUSC3 KPNA4 P4HA1 P4HA2 KPNA5 P4HA3 EIF4G3 SUMO1 KPNA2 HSPA8 EIF4G2 EIF4E3 KPNA3 SCAP TMEM258 VCP SEC11A SEC11C HYOU1 PRKG2 YBX1 DNAJA2 OST4 OSTC ATL2 STT3A KPNB1 STT3B PABPC1 XRN1 NACA XPO1 RPN2 CALR DDOST SPCS3 RPN1 SPCS2 SPCS1 DAD1 PDIA3 APOA1 DNAJC10 VIM DNAJC3 UFD1 CANX METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs BABAM1 H2AC6 BABAM2 H2AC7 UIMC1 ABRAXAS1 BRCA1 UBA52 PSMD14 H2AC17 H2AC12 KAT2B H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 UBB UBC RPS27A STAM EP300 NLRP3 STAMBPL1 STAMBP BARD1 MYSM1 ABRAXAS2 BRCC3 H2AC20 H2AC8 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development MCM2 SMARCB1 LIG1 PLK1 CCNB1 SMARCC1 SMARCC2 ATP6V1E1 ATP6V0B ATP6V1G1 CDH1 ATP6V0E1 CTNNB1 MET ATP6V1B2 ATP6V0D1 CDKN1A ATP6V0C CDKN2A CCND1 ATP6V1A YWHAB MAPK1 ATP6V1H SMARCA2 SMARCA4 MAPK3 ATP6V1C1 BCL2 CDK2 ACTL6A MAPK14 TCF7 GXYLT2 CDH2 STT3B SMARCD3 PXN TERT EDIL3 GSK3B CEACAM1 ZEB1 SIN3A PXDN BIRC7 ASAH1 XPO1 BCL2A1 TBX2 YWHAG EP300 TFAP2A PPARGC1A SMARCD1 CREBBP SMARCD2 ITGA2 SIRT1 LEF1 DIAPH1 TCF7L2 SMARCE1 TCF7L1 TNRC6C TNRC6A TNRC6B YWHAE SERPINE1 CSF1 CDC25B MC4R HINT1 EDNRB QARS1 ZIC1 RPS6KA1 TNFSF11 SOX9 DCT YWHAH TYRP1 TYR FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB PAX3 MITF POU3F2 YWHAZ SOX10 DARS1 MC3R LARS1 KIT TFEC EEF1E1 HDAC1 KARS1 ALX3 IARS1 MARK3 TBX3 POMC UBE2I AIMP1 AIMP2 ACTB MC1R EPRS1 ID1 GMPR MC5R SNAI2 SUMO1 PMEL BCL7A MLANA BCL7C DPF1 MYO5A BCL7B DPF2 DPF3 BRCA1 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 ARID1A GPR143 ARID1B AKT2 SOX2 AKT3 DICER1 TRPM1 WNT3A MOV10 AGO3 AGO4 USF1 AGO1 AGO2 MCM5 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis PPCS PANK2 PANK3 PANK1 DCAKD COASY PPCDC DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 AMER1 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 CTNNB1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 TLE4 APC TLE2 TLE1 TLE5 PPP2R1B PPP2R1A TCF7 AXIN1 ZRANB1 CSNK1A1 GSK3B CTBP2 CTBP1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D TLE3 PPP2R5C LEF1 PSMD8 PSMD6 FRAT1 PSMD7 FRAT2 PSMD2 PSMD3 TCF7L2 PSMD1 TCF7L1 BTRC SKP1 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy CSNK2B MAP1LC3A FUNDC1 ATG12 ATG5 CSNK2A1 ULK1 MAP1LC3B CSNK2A2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events PRKCB PRKCQ PRKCH RGSL1 PRKCE GNAI3 ADCY4 RGS4 PRKCD PRKCA ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADRA2C ADCY6 GNG3 ADRA2B GNAI1 ADRA2A ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 RGS20 GNAZ RGS17 RGS19 GNGT1 RGS16 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNAT3 GNAS GNB4 PRKCG GNB3 GNB5 ADCY9 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 MAN1B1 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria DYNLL2 MAPK8 BMF SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo LATS1 MOB1B MOB1A LATS2 AMOTL2 DVL2 AMOTL1 YWHAE YWHAB TJP1 NPHP4 CASP3 WWTR1 TJP2 WWC1 YAP1 STK4 SAV1 STK3 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity USP8 HGS LRIG1 EPS15 PTPN2 MET STAM2 SH3GL2 SH3GL1 UBA52 HGF PTPN1 UBB SH3GL3 PTPRJ SH3KBP1 UBC STAM RPS27A CBL SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease FGF9 FGF20 FGF23 FGF16 SOS1 FGF18 FGFR3 PIK3R1 PIK3CA NRAS GAB1 HRAS PLCG1 FRS2 FGF1 FGF2 FGF4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO2 UBE2I RWDD3 UBA2 SAE1 SUMO1 SUMO3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) MDH2 NNT KGD4 IDH3G SDHAF2 SDHAF3 ACAT1 SDHAF1 SUCLA2 SDHAF4 FH DLD CSKMT SDHC SDHD SDHA SDHB IDH2 ISCA2 ISCA1 CS LYRM4 IDH3B IDH3A ACO2 SUCLG2 SIRT3 SUCLG1 TRAP1 OGDH FXN DLST SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK GRB2 SOS1 LTK IRS1 TNK2 PIK3R2 ALKAL2 PIK3CA PIK3R1 ALKAL1 PIK3CB ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins CD4 ART1 DEFA1B PRSS3 PRSS2 DEFA6 DEFA4 DEFA5 DEFA3 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation CHUK TASL IRF5 IKBKB IKBKG SLC15A4 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin STAT5A STAT5B PLCG2 RAPGEF1 SOS1 PIK3R1 PIK3CA SHC1 JAK2 PIK3R5 EPOR CRKL NRAS LYN EPO GAB1 HRAS PLCG1 VAV1 PIK3CD IRS2 PIK3CB PIK3CG CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock UBE2D1 F7 FBXL21P SREBF1 PPP1CC CRY2 CRY1 PER2 KMT2A PER1 PER3 ATF2 CRTC2 CSNK1E HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 NPAS2 HELZ2 RAI1 TGS1 BHLHE41 NRIP1 NOCT EP300 KLF15 BHLHE40 TBL1X BMAL2 MEF2D PPARGC1A SIK1 NCOA1 MED1 RBM4 DBP NCOA2 CREBBP CIPC MEF2C NCOA6 NR1D1 SIRT1 NCOR1 TBL1XR1 CARM1 RORC PSMD8 RORB PSMD6 BMAL1 PSMD7 CLOCK PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 SERPINE1 PSMD11 PSMD14 NAMPT PSMD13 CUL1 PSMA7 CDK5 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A TFEB ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PPP1CB PSMC2 AVP PPP1CA RORA CPT1A RXRA PPARA FBXL3 CSNK1D CSNK2A1 CSNK2A2 CSNK2B TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation CHUK IFIH1 RNF135 TRIM25 APP MAVS RIGI NFKB2 RELA NKIRAS1 NKIRAS2 HMGB1 NFKB1 NFKBIA TRIM4 NFKBIB TRAF2 AGER S100A12 MAP3K1 S100B IKBKB SAA1 TRAF6 IKBKG SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) GATA4 PAX6 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 ISL1 FFAR1 GPR119 DPP4 GIP DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PHKB GYG2 GYG1 CALM1 PYGB AKR1E2 PYGM PYGL PHKA1 PHKA2 GAA AGL PHKG1 PHKG2 PGM1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins AGT GZMH CMA1 ACE2 REN CTSG ANPEP CPA3 CTSD MME CTSZ ATP6AP2 CES1 ENPEP CPB1 CPB2 ACE REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6A TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C NPAS4 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events PRKAG1 CALM1 PRKAG2 PRKACG PRKAG3 PRKACB RAC1 RPS6KA1 SRC GRIA2 NRAS MAPK1 HRAS GRIN2B MAPK3 RPS6KA6 CASK KPNA2 PRKAR1B GRIA1 LIN7A PRKAR2B LIN7C LIN7B PRKACA GRIA3 GRIA4 GRIN3B GRIN3A NBEA PRKX RASGRF2 CAMK2B ADCY1 RASGRF1 ACTN2 CAMK2D ADCY8 KIF17 CAMK2A GRIN2C NRGN PPM1E PRKAR2A PPM1F GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 PRKAR1A CAMK4 NEFL NRG1 CAMK1 PRKAB2 CAMK2G PRKAB1 CAMKK1 CAMKK2 PDPK1 GIT1 PRKAA1 RPS6KA3 PRKAA2 RPS6KA2 APBA1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development SMAD6 GLI3 SATB2 GLI2 BGLAP MAF HDAC3 SP7 CBFB COL1A1 SRC HES1 YAP1 ZNF521 UCMA RB1 IHH HEY1 HDAC4 ABL1 HEY2 MAPK1 WWTR1 HDAC6 YES1 MAPK3 SMAD1 SMAD4 AR RBM14 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism GOT2 RIMKLB PYCR1 PYCR2 PYCR3 GLUD1 GLUD2 GLUL OAT GLS GLS2 KYAT1 RIMKLA GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis ALDOB PPP2CA POM121C ALDOA PPP2CB NUP42 NUP62 NUP43 TPR NUP88 RAE1 PFKL NUP214 RANBP2 GNPDA1 PRKACG NDC1 NUP210 GNPDA2 NUP155 PRKACB PFKM NUP153 PFKP NUP93 NUP50 NUP35 NUP54 PGK1 NUP37 PFKFB2 PFKFB1 PFKFB4 PFKFB3 GPI NUP107 PGK2 ENO1 GCKR ENO2 ENO3 ENO4 PPP2R1B PPP2R1A PRKACA GAPDHS GCK ADPGK HK2 NUP160 HK1 HK3 NUP85 BPGM HKDC1 SEC13 GAPDH NUP133 PPP2R5D TPI1 PGAM1 PGAM2 PGM2L1 NUP205 POM121 NUP188 ALDOC AAAS RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation PPP1CC CSNK2B FURIN SPCS3 PPP1CB SPCS2 SPCS1 SEC11A SEC11C PPP1CA HSP90AA1 KPNB1 HSP90AB1 XPO1 HSPA8 CSNK2A1 CSNK2A2 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism SIRT1 PPARGC1A ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling TRPC5 TRPC6 TRPC3 NTN1 TRPC4 TRPC1 PITPNA PLCG1 TRPC7 DCC TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA MAPKAPK2 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 ZFP36 EXOSC9 YWHAB EXOSC8 EXOSC3 EXOSC2 EXOSC1 TNPO1 XRN1 DCP1A DCP2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production GATA4 GATA3 PHF21A GATA2 GATA1 RCOR1 HMG20B RAC1 DOCK6 DOCK9 H3-3B ITPK1 H3C8 KIF4B KIF4A AKAP1 H3C15 KIF20A IFNB1 KLC1 KLC4 KLC3 KLC2 DOCK3 ABL1 KIF11 KIF15 ZFPM2 KIF23 KIF22 CDK2 KIF26A VPS45 HBB SIN3A KIF18A DOCK8 DOCK10 DOCK5 DOCK4 HDAC2 JMJD1C IRF1 HBE1 GATA5 IRF2 AK3 MICAL1 CARMIL1 KIF2A HBG2 CDC42 HBG1 EHD1 MAFK KIF2C EHD2 KIF2B EHD3 MAFF RACGAP1 HBD AKAP10 SH2B1 CABLES2 DOCK2 DOCK1 PRKACG PRKACB CENPE MYB ZFPM1 CDK5 MFN1 MFN2 DOCK7 SH2B3 RBSN SH2B2 NFE2 HDAC1 CABLES1 WEE1 CAPZB IFNA5 IFNA4 CBX5 IFNA7 IFNA6 IFNA1 CAPZA1 PRKAR1B IFNA2 CAPZA2 IFNA8 PRKAR2B IFNA21 IFNA14 PRKACA IFNA16 IFNA17 TP53 IFNA10 KIF5C KIF5B KIF5A KIFAP3 PRKAR2A RAB5A KIF28P KIF12 KIF19 KIF13B KIF1C KIF21A PRKAR1A KIF1B KIF21B GATA6 KIF1A KIF25 KIF6 KIF27 RAD51B KIF9 RAD51C KIFC2 KIF16B KIFC1 KIF20B KIF3B KIF3A KDM1A KIF18B JAK2 KIF26B KIF3C MAFG DOCK11 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis ALAS1 CALM1 CYCS SOD2 PPARGC1B SIRT4 POLRMT ATP5F1B POLG2 ACSS2 TWNK SSBP1 IDH2 SIRT3 ESRRA RXRA PPARA ATF2 CRTC2 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 CAMK4 HELZ2 TGS1 HCFC1 TBL1X GLUD1 GLUD2 GABPA SIRT5 MEF2D PPRC1 PPARGC1A TFB1M NCOA1 PERM1 MED1 MTERF1 NCOA2 TFAM CREBBP MEF2C TFB2M NCOA6 NR1D1 NCOR1 TBL1XR1 CARM1 NRF1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs ALOX5 PTGS2 ALOX15 HPGD LTA4H DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU FMO3 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization TCHH TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ LIPN LIPM PRSS8 LIPK TGM5 RPTN CELA2A SPINK6 SPINK5 KAZN LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 FLG SPRR2E SPRR2F SPRR3 SPRR2G PERP CSTA KLK5 EVPL PPL KLK8 LCE2D LCE3C LCE3D LCE3A LCE3B LELP1 PI3 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B JUP KRT4 KRT3 KRT2 KRTAP17-1 KRT8 KRT7 KRT5 KRT9 KRTAP4-11 KRTAP20-1 KRTAP20-2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KRT33B KRTAP5-10 KRT33A KRTAP5-11 KRTAP16-1 KRTAP8-1 KRTAP26-1 KRT24 CAPNS1 KRT23 KRT20 KRT28 KRT27 KRT26 CAPN1 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 KRTAP25-1 KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 KRT14 KRTAP24-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRT1 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 PKP4 KRTAP10-2 FURIN KRTAP10-5 PCSK6 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 DSP DSG1 PKP1 DSG2 DSG3 KLK13 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER SERPINA1 GRIA1 TMED2 CTSC SEC24B SEC24A LMAN1L F5 F8 LMAN1 PREB STX5 SEC22B SEC24D SEC24C TMED10 LMAN2L GOSR2 LMAN2 CD59 MIA3 TGFA MIA2 CNIH1 CNIH2 CNIH3 FOLR1 COL7A1 CTSZ SEC23A AREG SAR1B MCFD2 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 TUFM MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MT-CYB MT-ND6 MT-ND4L MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 MTRF1 GFM2 MRRF MTRF1L MT-ATP6 MALSU1 MIEF1 MTFMT MTIF2 MTIF3 MTRFR MTRES1 MT-ATP8 MT-CO1 NDUFAB1 MT-CO2 MRPS17 MT-CO3 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated PPP2CA VRK3 PPP2CB DUSP6 PPP2R1B DUSP7 MAPK7 PPP2R1A PPP2R5D MAPK1 MAPK3 DUSP4 DUSP3 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling STAT4 STAT3 IL12RB1 IL23R P4HB IL12B JAK2 TYK2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 CHUK NFKBIA ZBP1 RIPK3 NFKBIB NFKB2 MYD88 RELA TICAM1 DHX9 IKBKB TLR3 NKIRAS1 NKIRAS2 RIPK1 IKBKG NFKB1 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs DNAJA1 DNAJA4 PGR DCTN2 DCTN3 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNC1H1 DNAJA2 ACTR1A HSPA1A DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 HSP90AB1 FKBP5 DCTN1 DYNLL1 FKBP4 HSP90AA1 HSPA1B STIP1 HSPA1L DYNLL2 NR3C1 CAPZB NR3C2 DYNC1I2 PTGES3 HSPA2 AR DNAJB1 HSPA8 CAPZA1 CAPZA2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins CDC14A AURKA PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 RB1 PSMC1 PSMC2 FZR1 SKP2 CDK2 NEK2 BUB1B CDC20 FBXO5 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC AURKB SKP1 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD2 FASTKD5 TBRG4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 PNRC2 EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 PPP2R1A RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 PPP2CA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 NCBP1 NCBP2 UPF1 RPS27A EIF4A3 CASC3 MAGOH PPP2R2A RBM8A GSPT2 GSPT1 UPF3B UPF3A MAGOHB RNPS1 UPF2 PABPC1 DCP1A ETF1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 PAK1 ARHGEF6 GNGT1 GNG10 GNGT2 GNG12 CDC42 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants KIT SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors SUMO2 PHC2 PHC1 CBX4 ING2 CBX2 PHC3 NPM1 TRIM28 NCOR2 BMI1 RING1 ZNF350 SIN3A DDX17 CTBP1 RNF2 NRIP1 EP300 MRTFA PPARGC1A NCOA1 ZNF131 NCOA2 CREBBP SAFB PIAS4 PCGF2 DDX5 PIAS3 PARK7 UHRF2 DAXX UBE2I TOPORS CASP8AP2 HIPK2 MBD1 PIAS1 SUMO1 SUMO3 CBX8 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix LAMB3 FURIN CD44 LAMA3 LAMC2 LAMB1 LAMC1 MMP9 KLKB1 DCN BCAN PRSS1 CDH1 CTRB2 CTRB1 CTSV CTSL CTSK BSG MMP13 ADAMTS4 ADAM10 ADAMTS5 ADAM17 ADAMTS1 SPP1 ADAMTS8 ADAMTS9 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 ADAMTS16 COL25A1 COL23A1 ADAMTS18 NID1 ACAN COL9A1 COL9A3 ELANE COL9A2 CAST CAPNS1 CAPNS2 CAPN2 CAPN1 KLK2 PSEN1 CAPN15 PHYKPL NCSTN OPTC KLK7 ADAM15 MMP20 MMP25 MMP24 CMA1 TPSAB1 A2M MMP10 MMP12 MMP11 MMP15 MMP17 MMP19 CASP3 MMP1 TMPRSS6 CAPN8 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM9 ADAM8 HTRA1 TIMP2 TIMP1 SCUBE3 SCUBE1 MMP8 PRSS2 SPOCK3 CAPN13 CTSG MMP14 MMP16 CAPN14 CAPN11 CAPN12 CAPN10 HSPG2 MMP7 CTSS PLG CTSB MMP3 BMP1 TLL2 CTSD TLL1 MMP2 LAMA5 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism HPRT1 APRT PNP ADA G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC26A1 SLC35B3 SLC35B2 PAPSS2 PAPSS1 SLC26A2 SLC26A11 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C19 CYP2C9 EPHX2 CYP2C8 CYP1B1 CYP2J2 CYP1A2 CYP1A1 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2C19 CYP2E1 CYP2F1 CYP2A7 CYP2C9 CYP2A6 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling ARPC1B ARPC1A CFL1 RASA1 WASL PTK2 KALRN RAC1 LIMK2 LIMK1 SDC2 GRIN1 RHOA ROCK1 ROCK2 ACTG1 PAK1 ARPC4 ARPC5 ARHGEF28 ITSN1 ARPC2 ARPC3 ACTR3 LYN ACTR2 HRAS GRIN2B ACTB CDC42 YES1 TIAM1 FYN TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PPIE COPS3 COPS6 ERCC4 ERCC1 ELL ERCC5 COPS8 LIG1 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 XRCC1 LIG3 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 COPS5 MNAT1 POLK POLE AQR ERCC8 RFC5 RFC3 RFC4 RFC1 RFC2 PRPF19 ISY1 GPS1 PCNA POLD3 POLD4 COPS4 POLD1 COPS2 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 XPA RPA3 COPS7B POLE2 COPS7A POLE3 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport PLB1 LRP1 LRP8 APOM AKR1C3 GPC1 HSPG2 GPC3 GPC2 BCO2 APOA2 SDC4 APOA4 SDC2 RDH11 GPC5 BCO1 SDC3 GPC4 LRP10 GPC6 AKR1B10 LRP12 AGRN LPL APOB SDC1 LDLR LRAT GPIHBP1 APOE APOA1 APOC3 AKR1C1 APOC2 TTR AKR1C4 RBP4 LRP2 RBP2 CLPS RBP1 RETSAT PNLIP TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 MAP2K7 MAP2K6 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ ITGA2B SERPINA1 ALDOA SOD1 FN1 F5 F8 PSAP CD9 EGF CLU PRKCG SERPING1 TF VEGFA PPBP HGF TGFB1 APOA1 LAMP2 PCDH7 PPIA PRKCB CALM1 APP SERPINE1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 CD109 TAGLN2 NHLRC2 STXBP3 TEX264 STXBP2 PDGFB ENDOD1 A1BG APOH VTI1B RAB27B MANF PROS1 A2M APOOL CALU MAGED2 HRG FERMT3 SERPINA3 HSPA5 ORM1 ECM1 OLA1 CTSW ORM2 SERPINA4 TMSB4X TIMP3 GAS6 STX4 ALB QSOX1 AHSG ANXA5 TOR4A CD63 SPP2 LEFTY2 LY6G6F VEGFB VEGFC VEGFD TIMP1 LHFPL2 PCYOX1L TGFB2 F13A1 BRPF3 POTEKP TUBA4A CD36 CFL1 FAM3C ABCC4 APLP2 TMX3 SELENOP SCG3 PRKCA RARRES2 PFN1 CYRIB SELP FLNA SCCPDH ACTN2 LGALS3BP WDR1 PLEK PHACTR2 CYB5R1 SRGN KNG1 MMRN1 PECAM1 CAP1 ITIH4 IGF2 ITIH3 THBS1 IGF1 PLG TTN TGFB3 CLEC3B CDC37L1 CFD ITGB3 ACTN1 FGB FGA VWF FGG TLN1 VCL PF4 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland TGFA EGF AREG FGF10 PRL ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 PRKAR2A ROBO2 PRKACA PRKACG PPP3CB PRKCA PRKACB AKAP5 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE TLR3 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes EP300 FOXO4 FOXO1 BBC3 BCL6 NFYA FASLG STK11 NFYB CREBBP NFYC FOXO3 BCL2L11 DDIT3 CITED2 PINK1 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A1 SLC26A9 SLC26A6 SLC26A4 SLC26A2 SLC26A3 SLC26A7 SLC26A11 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors TNFRSF6B TNFSF18 TNFSF14 TNFSF15 EDARADD EDAR LTA TNFRSF14 TNFRSF1B TNFRSF11B TNFRSF1A TNFSF11 CD27 TNFRSF13B EDA2R CD70 EDA TNFRSF18 TNFSF6 TNFSF4 TNFSF9 TNFSF8 TNFRSF8 TNFRSF4 TNFSF13 TNFRSF17 TNFRSF9 TNFSF13B TNFRSF25 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 RIPK3 PPP2R5D MEF2C TRAF2 UBE2D3 IKBKB BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 RELA RPS6KA1 TICAM1 TANK TRAF3 ATF1 UBB IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 TP53 TLR3 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 CD274 PSMA6 PSMA3 PSMA4 PSMA1 CUL3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CSNK2A1 ADRM1 CSNK2A2 SEM1 YWHAG CSNK2B RBX1 PSMC5 PSMC6 PSMC3 PSMC4 SPOP PSMC1 PSMC2 CCND1 PSMD8 PSMD6 CDK4 PSMD7 PSMD2 PSMD3 PSMD1 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants DUSP16 MAPK1 DUSP6 DUSP7 DUSP10 DUSP8 DUSP9 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases HCK FLT3LG FYN SYK FLT3 LCK DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors ADORA2B ADORA3 ADORA1 ADORA2A MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling GAB1 MET HGF PIK3CA PIK3R1 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism NT5C ITPA AGXT2 NT5C1A DPYS DPYD NT5M UPP2 UPP1 UPB1 TYMP SAMHD1 NT5E NUDT15 XDH NUDT16 ADPRM NUDT5 GDA DNPH1 ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C2 PNP ENTPD1 ENTPD5 NT5C1B NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase NOS3 NOS1 KCNMB1 KCNMA1 PDE1B PDE2A PDE1A PRKG2 GUCY1A2 GUCY1A1 PDE5A KCNMB2 ITPR1 KCNMB3 KCNMB4 NOS2 IRAG1 PDE9A PDE11A GUCY1B2 PDE10A GUCY1B1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition GXYLT2 CDH2 STT3B PXN EDIL3 SOX2 ZEB1 PXDN SERPINE1 CDH1 ITGA2 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes CHUK UBA7 UBE2L6 IFIH1 HERC5 FKBP5 TRIM25 ATF6 RIGI HSPA5 IFI6 IFI44L IKBKB ARIH1 EIF2AK3 ISG15 IKBKG IFI27 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome GLI2 PSMA5 PSMA6 PSMA3 PRKACA PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PSMD11 PRKACB PSMD14 PSMD13 CUL1 PSMA7 CSNK1A1 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SUFU PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 FGF9 FGF20 FGF23 FGF16 SOS1 FGF19 FGF18 PIK3R1 PIK3CA FGFR4 NRAS GAB1 FRS3 HRAS KLB PLCG1 FRS2 FGF1 FGF2 PTPN11 FGF4 FGF6 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division PLK1 KIF20A SMC1A PDS5B PDS5A NIPBL KIF23 RAD21 WAPL MAU2 STAG1 SMC3 STAG2 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation BANF1 LIG4 XRCC4 XRCC6 XRCC5 HMGA1 PSIP1 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT GALT RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNK CCNT2 ELL CCNT1 ELOA AFF4 ELOB CDC73 NELFB MLLT1 ELOC MLLT3 NELFCD SUPT6H NELFA IWS1 NELFE EAF1 SUPT16H EAF2 NCBP1 SKIC8 NCBP2 CTR9 CTDP1 RTF1 SUPT4H1 LEO1 PAF1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGLV3-25 IGLV3-27 PTPN6 IGKC IGLV3-21 CD79B IGKV1-39 CALM1 DAPP1 CD79A IGKV1-33 IGHV3-53 IGHM BLNK IGLC7 IGKV5-2 IGKV1-5 IGLC6 IGHD BLK VAV1 SH3KBP1 PIK3AP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 AHCYL1 IGHV3-33 IGKV1D-39 IGKV1D-33 BTK IGKV2D-28 IGKV4-1 PLCG2 IGHV7-81 SOS1 CD19 IGKV2D-30 SYK IGHV4-59 IGHV1-69 STIM1 ORAI2 ORAI1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 ITPR1 IGLV1-44 IGKV3-15 ITPR2 IGKV3-11 ITPR3 PIK3CD IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CD22 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3R1 IGKV2-29 IGKV2-28 IGLC3 NCK1 IGLC1 IGLC2 LYN TRPC1 IGKV3D-20 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis ATM ACD H2AX ATR SPO11 SUN2 TEX15 MSH4 DMC1 MSH5 PSMC3IP LMNB1 MND1 MLH3 H3-3B SYCP2 SYCP1 SYNE2 H3C8 SYNE1 SUN1 TEX12 TERF1 TERF2 SMC1B H2AJ SYCE3 SYCE2 POT1 SYCE1 TERF2IP REC8 STAG3 SYCP3 H3C15 MLH1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 UBE2I H2BC1 CDK4 CDK2 H2AB1 SMC3 H2AC8 H2AC6 H2AC7 MRE11 BRCA1 BRCA2 FIRRM PRDM9 NBN H2AC19 H2AC14 H2BC12L RAD21 H2BC26 TOP3A STAG1 H2BC21 STAG2 RAD51C H2BC17 BLM H2BC12 H2BC13 H2BC14 H2BC15 FKBP6 SMC1A H2BC11 FIGNL1 RBBP8 H4C9 TINF2 RPA1 RPA2 HSPA2 RAD50 H2AZ2 RAD51 RPA3 H2AC20 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation RPL27A KDM8 RPS23 OGFOD1 ZC3H15 RWDD1 RPL8 RPS6 JMJD4 ASPH JMJD7 RIOX1 U2AF2 ETF1 RIOX2 JMJD6 DRG1 DRG2 F9 RCCD1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface PDZD11 ATOX1 ATP7A SLC11A1 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation PRKAR2B CALM1 PRKACA PRKACG ADCY4 NBEA PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A ADCY9 PRKAR1B DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 CYP21A2 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 KHDRBS1 KHDRBS2 KHDRBS3 SFPQ INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport CYGB MB NGB REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 OMA1 PSMD14 PSMD13 OPA1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 ARHGAP10 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins MAGT1 UBA52 UBB UBC RPS27A PRMT1 UBE2I ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 TUSC3 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 SUMO1 MGAT5 ST3GAL4 GSK3A MGAT1 PARP6 MGAT2 GOLGA7 PARP4 TMEM258 ST3GAL1 GALNT1 ST3GAL2 PARP16 PARP9 ST3GAL3 ST6GAL1 PARP14 PARP8 EDEM2 MOGS PARP10 ZDHHC11 MGAT4C ZDHHC9 SRPK2 MGAT4A OST4 SRPK1 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 OSTC STT3A CSNK1A1 STT3B GSK3B RPN2 DDOST RPN1 DAD1 CANX VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A DNAJC3 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors HSPH1 COL1A1 COL1A2 FTH1 FTL IGHV3-23 APOE IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 SCARF1 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 COLEC12 IGKV3-11 MSR1 SCARA5 V2-8 V1-20 MARCO HBB IGKV2D-40 SCGB3A2 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 HMGB1 IGLV2-23 APOB CALR IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV COL3A1 IGKV2-29 COL4A2 IGKV2-28 IGLC3 COL4A1 IGLC1 APOA1 IGLC2 HBA2 V1-9 HSP90AA1 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 LRP1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 SPARC PRDX1 S100A9 ALB SAA1 STAB1 CD36 HYOU1 HP HPR HPX IGHA1 IGHA2 AMBP JCHAIN HSP90B1 CD163 MASP1 STAB2 COLEC11 CD5L SSC5D APOL1 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism SFTA3 CSF2RB SFTPC SFTPD CSF2RA SFTPB ABCA3 SFTPA1 SFTPA2 SLC34A2 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling PPP2CA PPP2CB PPP2R1A UBA52 ANOS1 UBB FGF1 FGF2 UBC FGF3 FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF22 MKNK1 SPRY2 FGF10 MAPK1 MAPK3 FRS2 BRAF PTPN11 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PTK6 PSMC1 CDKN1A PSMC2 CDKN1B CKS1B CCND1 SKP2 CCNE2 CDK4 CCNE1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling CXCL8 VAV1 PAK1 MAPK7 TIAM1 DGKG DGKE DAGLA C5AR1 DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI DGKH RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 GRK3 ARHGEF10L PIK3CG AKAP13 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 RHOB PDPK1 C3 C5 ARHGEF3 ARHGEF1 ARHGEF2 PIK3CA ARHGEF25 ECT2 CDC42 NET1 ABR ADRA1D ADRA1B ADRA1A GPR176 ARHGEF40 GPR15 PLEKHG2 GPR27 ARHGEF15 GPR25 PLEKHG5 GPR20 ARHGEF19 GPR32 RHOC GPR45 TIAM2 GPR150 OBSCN GPR83 ARHGEF4 GPR84 ARHGEF7 PRKACG NGEF PDE2A PPP1R1B ARHGEF6 FGD1 PDE3A PRKACB FGD2 CCL4L2 RGS8 GNA13 FGD3 PDE8B FGD4 PDE8A TBXA2R PCP2 GRK6 GNA12 ARHGEF33 GPSM1 ARHGEF35 GPSM2 ARHGEF37 PDE4A ARHGEF39 GPSM3 ARHGEF38 PDE4D PLXNB1 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 PDE7B PDE7A OPN1MW CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P GNAT3 HRH1 HTR6 C3AR1 HTR7 RGS9 RGS6 ADCY9 RGS7 HRH2 PRKAR1B HRH4 DRD1 BTK PRKAR2B DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D GNAI3 ADCY4 TAAR5 ADCY3 HTR1B TAAR2 PRKX ADCY2 HTR5A TAAR1 ADCY1 ADCY8 GPR143 GNAQ ADCY7 ADRB3 ADCY6 GNAI1 ADCY5 GNAI2 CAMK4 CYSLTR1 CYSLTR2 GNAZ GNA14 GNA15 GNA11 ADORA2B RGS11 PLCB4 PRKCG KPNA2 GNAL NBEA EGFR RASGRF2 ARHGEF9 CAMKK1 CAMKK2 GABBR2 GABBR1 PRKCB RHO GNAT1 SAA1 GNAT2 PRKCA PLCB3 PLCB1 PLCB2 PRKAR1A PPP3CC MCHR1 ITGA5 TRPC7 TRPC6 TRPC3 SST SRC NRAS SSTR3 MAPK1 HRAS MAPK3 PRKCQ SOS1 RASGRP2 ARHGEF18 RHOA OPN1SW ITGB1 TRIO ITSN1 PREX1 MCF2L ARHGEF16 PPP3CA PPP3CB RASGRP1 PPP3R1 CALM1 CCR5 ARHGEF5 APP ARHGEF26 KALRN MC4R EDNRB CDK5 MCF2 RPS6KA1 EDN1 EDN3 GLP1R VIPR1 MC3R VIPR2 SCT ADM PTH1R GNGT1 PPP1CA POMC GNGT2 MC1R MC5R GLP2R PTH2R GIP MGLL ADCYAP1 CRH IAPP ADCYAP1R1 CGA RAMP2 CALCA TSHB RAMP3 VAV3 CALCB CALCRL PTH GIPR PTH2 CX3CR1 VAV2 PTHLH CRHR1 GHRHR GNG10 PRKAR2A GNG3 CALCR GNG2 GNG5 GNG4 GNG7 GNG8 ROCK1 CXCR4 ROCK2 CXCL12 GCGR SCTR SOS2 GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH GNB1 PF4 GNAS PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 VIP GALR3 RAMP1 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR31 RGR CCL13 CCL19 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 HBEGF ANXA1 ADORA2A P2RY4 CCL5 CCL4 CCL1 APLN TAS2R20 RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 PPP2R1B TAS2R40 PPP2R1A TAS2R41 TAS2R42 TAS2R43 LHB TAS2R45 TAS2R46 MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP ADRA2C TAS2R38 ADRA2B TAS2R39 ADRA2A TAS2R60 PTGDR2 CX3CL1 CCR9 PDE3B CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 PPP2R5D NPW CXCR3 CXCR2 NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 PPP2CA TAS2R9 PPP2CB CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 RGSL1 GRM3 GRPR GRM2 EDNRA GRM4 PROK2 GRM7 PROK1 GRM6 UTS2R GPER1 NPFF GRM8 TRHR TAS2R1 UTS2B TAS2R3 AGTR1 TAS2R5 PTGFR TAS2R4 LPAR1 PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR TAS1R2 LPAR5 S1PR3 LPAR6 TAS1R1 NMS S1PR2 NMU S1PR5 GNRH2 TAS1R3 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY AVPR2 BRS3 ACKR3 GPRC6A OXT GPR132 AVP CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR AHCYL1 NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 PRKACA F2RL2 F2RL3 GPR68 PDE1C GPR65 PDE1B PDE1A PMCH RGS4 GRK2 PRKCD RGS5 RGS2 PLA2G4A RGS3 RGS1 GHSR OPRM1 CAMK2B CASR CAMK2D F2R CAMK2A LTB4R2 UTS2 ITPR1 NTS ITPR2 KNG1 AKT2 MCHR2 ITPR3 GRK5 AKT3 TAC3 TAC1 AKT1 CRHR2 OPN4 NMUR2 NMUR1 CAMK2G MLNR TRH LTB4R GRM1 OPRK1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 ARRB1 XCL2 PIK3R3 XCL1 PIK3R2 ARRB2 PIK3R1 RGS18 RGS17 PIK3R6 RGS19 PIK3R5 RGS13 RGS16 P2RY6 P2RY2 RPS6KA3 P2RY1 RPS6KA2 RGS21 CCK HCRTR2 HCRTR1 KISS1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine NAGK AMDHD2 RENBP UAP1 PGM3 GNPNAT1 GFPT2 GFPT1 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis UBE2L6 TRIM25 UBA52 POLK POLE POLH RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 ISG15 RPS27A UBA7 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 USP10 POLE4 PCLAF POLI RPA3 USP43 POLE2 REV1 POLE3 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation CBX6 TNKS2 PHC2 WWP2 EZH2 RNF146 PHC1 FRK CBX4 OTUD3 CBX2 RCOR1 PHC3 RPTOR RRAGA USP7 RRAGC RRAGB BMI1 RRAGD RING1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 RNF2 LAMTOR3 LAMTOR5 SUZ12 MAPK1 MAPK3 ATF2 HDAC3 MBD3 MLST8 EED GATAD2B GATAD2A EGR1 HDAC5 HDAC2 HDAC7 PSMD8 CHD4 RBBP4 CHD3 PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 XIAP PSMD1 MTOR PML TNRC6C PSMA5 TNRC6A SALL4 PSMA6 MTA2 TNRC6B PSMA3 PSMA4 PSMA1 REST JUN PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 ATN1 PSMC1 MAF1 PSMC2 MTA1 HDAC1 MTA3 SNAI2 NEDD4 PPARG TP53 NR2E1 MECOM PTEN AKT2 AKT3 AKT1 CSNK2A1 CSNK2A2 CSNK2B KDM1A SNAI1 MOV10 AGO3 AGO4 PREX2 TRIM27 AGO1 MKRN1 AGO2 USP13 TNKS CBX8 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN DNM2 NOS3 WASL CAV1 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones MEAF6 YEATS4 EPC1 TADA2B H3C8 KAT6A JADE1 JADE3 H3C15 JADE2 KAT7 SUPT20H ATXN7L3 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 ENY2 H2BC9 TAF5L H2BC8 DMAP1 H2BC5 MRGBP TADA1 H2BC3 ING4 ING3 VPS72 H2BC1 MSL2 MSL3 SUPT3H MSL1 TAF6L ACTL6A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 H2AC8 ELP6 H2AC6 H2AC7 ATF2 KAT8 MBIP KAT14 H2BC26 DR1 H2BC21 WDR5 TADA2A EP300 ZZZ3 YEATS2 TADA3 H2BC17 SGF29 H2BC12 H2BC13 NCOA1 H2BC14 H2BC15 NCOA2 KANSL1 CREBBP KANSL2 KANSL3 H2BC11 RUVBL1 CLOCK RBBP7 MCRS1 H2BC18 USP22 PHF20 OGT TAF9 PAX3 TAF12 TAF10 ACTB BRPF1 BRPF3 ING5 KAT5 BRD1 H2AC17 H2AC12 KAT2B RUVBL2 KAT2A H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 ATXN7 SAP130 HCFC1 H4C9 TRRAP EP400 H2AC20 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A EP300 PIP4K2B ING2 PIP4P1 TP53 MAP2K6 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM SLC34A2 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions PTGS1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 TGFBR2 TGFB1 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation HSP90AA1 HDAC6 HSF1 VCP YWHAE HSBP1 RPA1 RPA2 PTGES3 HSP90AB1 RPA3 EEF1A1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism PRKAG2 CSNK1G2 B3GNT3 NOS3 OSBPL1A CYP19A1 FADS2 FADS1 THEM4 PIK3CD PIK3CB PIK3CG UQCRB UQCC3 PIK3CA UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 PRKAA2 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH LYRM4 UQCRQ LYRM7 UQCRC1 UQCRFS1 UQCRC2 CYC1 MT-CYB FXN TIAM2 ACOT8 EHHADH HSD17B4 ACAA1 DECR2 ABCD1 SLC27A2 ACOT4 SEPHS2 SECISBP2 EEFSEC SEPSECS PSTK INMT SARS1 GNMT SCLY STARD5 SLC10A1 SLC10A2 SLC51A SLC51B SLC27A5 CHRM3 GBA1 PTS SPR PDSS2 PDSS1 GCH1 STARD7 COQ9 COQ7 COQ6 COQ5 GCHFR COQ4 HPDL COQ3 COQ2 COQ8B COQ8A GAPDHS TP53 GNAQ ZDHHC21 UGT1A3 SPHK1 CDA GDA PFAS DNPH1 ATIC PPAT TK2 ADSL GNA14 ENTPD2 GNA15 ENTPD3 ENTPD4 ENTPD6 CAD GNA11 ENTPD7 ENTPD8 UMPS GART NT5C2 PAICS DHODH UCKL1 UCK2 NUP205 UCK1 PUDP POM121 NUP188 NT5C1B ADSS1 ADSS2 AAAS POM121C ITPA NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 UGT1A10 ABHD10 UGT2B10 UGT2B11 UGT2B15 RPL4 UGT2B17 RPL5 SLC35D1 RPL30 RPL3 UGT3A2 RPL32 UGT3A1 NAT1 RPL31 NAT2 RPL34 UGT2A3 RPL10L UGT2A2 RPL10A UGT2A1 RPL8 UGT1A1 RPL6 UGDH RPL7 UGT2B4 UGT2B7 RPS15 UGT2B28 RPS14 UGT1A5 RPS17 UGT1A4 RPS16 UGT1A9 RPL18A UGT1A8 RPS19 UGT1A7 RPS18 UGT1A6 RPL36AL RPL36 RPL35 PTGDS RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 ABHD3 PCTP RPS12 CEPT1 RPS9 MFSD2A RPL21 PCYT1B RPS7 CHKB RPS8 PCYT1A RPL23 CHKA RPS5 STARD10 RPL22 RPS6 PHOSPHO1 PEMT RPSA RPL9P9 CHPT1 RPL24 RPL27 CYB5B RPL26 LYPLA1 RPL29 CYGB RPL28 DDAH1 KPNB1 RPS4Y2 RPS4Y1 SMPD3 RPL39L SMPD2 RPL41 GLYATL3 GLYATL2 RPL3L RPS26 GLYATL1 RPS25 ACSM2A RPS28 ACSM5 RPS29 ACSM4 GLYAT TTPA RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A PPA2 RPLP2 HSP90AA1 RPL13A RPS3A GADL1 APIP MRI1 RPL37A CSAD ADO RPL10 TXN2 RPL12 CBS RPL11 ENOPH1 RPL36A MPST RPS27L RPS15A GOT1 TSTD1 BHMT2 RPL14 SQOR RPS3 GOT2 RPL13 RPL15 FMO1 SUOX RPS2 BHMT RPL18 MTAP RPL17 TST ADI1 RPL19 CTH RPL35A ETHE1 RPL23A RPL22L1 SLC25A10 CDO1 FAU RAN RPL26L1 PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 SLC6A7 VNN1 NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT RGL1 ABCC1 ALOX15 CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 PTGR1 SMPD1 ALOX5AP CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ACOXL MECR SLC25A27 UCP3 UCP2 SLC25A14 AGPAT5 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 PLA2G4B PLA2G2A DDHD2 DDHD1 GNPAT LPCAT4 PLA2G10 GPD1 GPD1L PLA2R1 NMT2 MLXIPL ADIPOQ ADIPOR1 ADIPOR2 ASAH1 COX19 COX17 PLIN2 CS PXMP2 ACO2 NMT1 TIMM21 NDUFB8 TAFAZZIN IDH3G QARS1 VAPA RARS1 ACAD8 HIBADH ACADSB MARS1 ALDH6A1 BCAT1 SLC25A44 BCAT2 DARS1 LARS1 EEF1E1 KARS1 ECHS1 IARS1 ACSM3 ACSM6 HADH ACADS POMC AIMP1 AIMP2 EPRS1 CAV1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 GSTM1 TPMT ABCC5 NME2 GMPS NME1 IMPDH1 GUK1 GSTA2 IMPDH2 RAB5A GSTA1 HPRT1 CA1 NUDT15 ETFB XDH CA2 CA4 HSP90AB1 KCNG2 BST1 NDUFAB1 KCNC2 GCSH STK11 KCNB1 KCNS3 PGK1 ACY1 SNAP25 VAMP2 STX1A TM7SF2 GGPS1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK ACADVL INSIG2 SAR1B INSIG1 ACACB ACACA PMVK SCAP SC5D FDFT1 FDPS MBTPS1 SEC24B FOLR2 SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SEC24D SEC24C MBTPS2 ACY3 GGT7 GGT6 MGST3 MGST1 MGST2 AKR7L AKR7A2 AKR7A3 GGT3P MT-ND6 CYCS MT-ND4 MT-ND5 MT-ND2 SLC22A5 MT-ND3 MT-ND1 ATP5MC2 ATP5MC3 LPGAT1 CPNE7 CPNE6 ATP5MC1 CPNE1 MT-ATP6 CPNE3 PCYT2 ATP5F1A PISD PLA2G15 PGP ATP5F1B PLA1A ATP5MK ABHD4 PGS1 ATP5MJ ATP5MG PTPMT1 OSBPL8 ATP5MF OSBPL5 ATP5ME DMAC2L DGAT2L6 CRLS1 HSPA9 ATP5PF CDS2 OSBPL10 ATP5PD PLAAT1 PLAAT2 GPCPD1 ATP5PB PLAAT5 PLAAT4 SELENOI MBOAT1 ATP5F1C ATP5F1D ETNPPL ETNK2 MT-ATP8 ETNK1 ATP5F1E PNPLA3 FFAR1 ATP5PO AHCYL1 AGT PRKACA ITPR1 ITPR2 ITPR3 KCNJ11 MCEE PCCA MMAA PCCB MMUT FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA TXN MMAB MMACHC MMADHC NRF1 OGDH DLST MCCC2 MCCC1 PPM1K AUH IVD HIBCH STS ARSA SUMF2 SUMF1 TPST2 TPST1 CYP24A1 DHFR2 ARSL PRSS1 ARSJ NADSYN1 FLAD1 CTRB2 ARSK CTRB1 SLC5A8 ARSH BTD ARSI MTHFD1 MTHFD2 ARSF MTHFD2L SHMT1 ARSG HLCS ARSD SLC19A3 PNPO SLC19A1 SLC19A2 CBLIF MTHFR MTHFS TCN1 CD320 MOCS2 MOCS3 QPRT THTPA SLC22A13 NMRK2 PLCG1 RFK NMRK1 CD38 VKORC1 MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 NMNAT1 VKORC1L1 ALDH1L1 ALDH1L2 NUDT12 SLC25A51 UBIAD1 NADK SLC52A2 SLC52A3 SLC52A1 GPHN NADK2 NAPRT ACP5 AOX1 SLC25A19 PDXK NAXE SLC25A32 NAXD PPA1 LHPP PIP5K1C ALOX5 PTGS2 SYNJ2 ABCC8 PIK3C2A CYP2R1 TPH2 ASMT AANAT LRP2 CLPS ALPI PNLIP SLC25A18 MDH1 MDH2 SLC25A12 SLC25A11 SLC25A22 SLC25A13 SLC3A2 CES2 PECR PHYKPL CROT SCP2 NUDT19 SLC36A4 GSTK1 PHYH PIPOX BAAT ACOX2 SLC6A12 AGPS SLC7A5 ACOT2 ACOX3 AGXT PAOX DDO HACL1 HAO1 HAO2 EPHX2 NUDT7 AMACR DAO CRAT ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 MED19 MED18 MED11 MED29 MED28 MED22 MED21 MT-CO1 MED13L SLC22A4 SCO2 MT-CO2 MT-CO3 PPARGC1B MED9 CDK19 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 SIRT3 MED23 MED25 MED24 MED20 PPARD ISCA2 ISCA1 CMC1 PYURF SCO1 TMEM126A ALOX12 SUCLG2 SUCLG1 TMEM126B PODXL2 ABHD14B TRAP1 SULT1A1 SURF1 SULT1C2 NDUFAF8 SULT1B1 NDUFAF6 SULT1E1 NDUFAF7 NDUFAF4 BPNT2 NDUFAF5 BPNT1 NDUFAF2 SULT6B1 SULT1A4 SFXN4 NDUFAF3 SULT4A1 SULT1A3 NDUFAF1 SULT1A2 HCCS SULT2A1 TMEM186 SULT1C4 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH DMAC1 DMAC2 PET117 TIMMDC1 PET100 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT SDHC SDHD SDHA SDHB NDUFB10 COX16 NDUFB11 COX18 COX11 MED30 COX14 NDUFV3 NDUFV2 NDUFV1 MED31 COA3 COA1 IDH2 HIGD2A COX20 ETFA TMEM223 IDH3B IDH3A COA5 NDUFC2 NDUFC1 PTPN13 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 CD36 NDUFB5 G6PC1 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 SUCLA2 COX4I1 HGD COX4I2 PTEN TAT FAH HPD ARNT CYP46A1 CYP39A1 RRM2B POR GSTP1 CYP27B1 CYP11B1 NQO1 GSTA3 GCLC GCLM ME1 ABCC3 GPX1 BLVRB BLVRA SLC27A1 CCNC ADHFE1 D2HGDH L2HGDH APOE PCK1 COX7B COX7C CTSL COX8A SREBF1 COX8C COX5B COX5A RXRB COX6C GCK COX6A1 COX6A2 G6PD COX6B2 COX6B1 DHRS7B GLUD1 HIGD1C GLUD2 SIRT5 GC IP6K2 SRD5A2 SRD5A1 CYP17A1 INS RRM2 GLS SAMHD1 NAMPT PIP4K2A PIP4K2B RIDA SDS GAMT SDSL MED8 MED4 MED6 MED7 RAB4A GPI PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PNPLA8 PIP4P1 PLA2G4C MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 NCOR2 GPS2 GM2A DHFR TK1 TYMS GLIPR1 ORMDL3 PTGES2 ALDH3B1 DEGS1 GLA PSAP ESRRA CDK8 LHB ACBD4 HSD11B1 HSD11B2 SERPINA6 DMGDH CHDH SARDH ALDH7A1 FMO2 SIN3A FMO3 CERK LBR GBA3 GBA2 OSBP GPX2 MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 UGCG UGT8 ALDH3B2 SGPL1 B4GALNT1 KDSR GLS2 B3GALNT1 ACER2 FA2H ACER1 ACER3 DEGS2 GAL3ST1 SPTLC1 SMPD4 SPTLC2 SPTLC3 A4GALT CERS3 CERS4 TXNRD1 CERS5 CERS6 SPHK2 CERS1 CERS2 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB SPTSSA ORMDL1 SGPP2 SGPP1 GALC CH25H OSBPL9 COX7A2L OSBPL7 OSBPL6 OSBPL3 OSBPL2 AKR1B15 HSD17B14 HSD17B11 HSD17B2 MARCKS IPMK MINPP1 SYT5 MLX ARNT2 GLDC HYKK COXFA4 TDO2 CKMT1B COX7A2 HOGA1 COX7A1 IDO2 IDO1 CACNA1D GCDH OAZ1 OAZ2 ACMSD OAZ3 AFMID RIMKLA RIMKLB PYCR1 PYCR2 PYCR3 SLC6A8 KYAT3 PHGDH AASS ARG2 OAT HAAO SLC2A3 ODC1 CKM QDPR IL4I1 AADAT BBOX1 PAH AGMAT PCBD1 KYAT1 GATM SAT1 ASRGL1 PSPH KMO SMS AZIN2 AZIN1 GRHPR MTMR4 SERINC1 SERINC3 SERINC2 SERINC5 SERINC4 SLC25A2 AMD1 DHTKD1 KYNU AMT ALDH9A1 SRM CKMT2 SRR SLC25A21 CRYM TMLHE PSAT1 IQGAP1 HPGD LTA4H CYP2J2 CYP3A43 AHR CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 GSTT2 CYP1A2 GSTT1 CYP1A1 AHRR OPLAH CNDP2 CYP2E1 CYP2F1 HPGDS ESD CHAC2 CHAC1 GSTT2B GSTM4 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT GSTA5 GSTA4 GSTM5 ABCB7 CIAO3 NUBP1 NUBP2 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B ABCG2 ACOT9 ACOT7 ACOT1 FAR1 FAR2 MCAT PRXL2B HMOX2 ACOT7L PTGR2 PTGS1 G0S2 THEM5 FHL2 FAAH2 ACO1 TNFRSF21 HSD17B13 AWAT1 SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 CPT1B PTGES ALOX15B HILPDA ANKRD1 CBR1 FITM1 FITM2 SLC9A1 GRHL1 CA9 ACAA2 ACOT11 HIGD1A ACOT12 BCKDK ACOT13 BCKDHA DBT ACBD7 BCKDHB ACBD6 DLD ACSF2 DBI CPT2 PON3 PON2 PON1 PRKACG LDLRAP1 PRKACB CUBN AMN APOA2 APOA4 APOA5 ANGPTL4 CES3 LPL LDLR GPIHBP1 ABCA1 NR1H3 APOC3 APOC2 ALB IDH1 RAPGEF3 SLC35B3 RAPGEF4 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 ENO1 ENO2 HS6ST1 ENO3 ENO4 HS6ST2 HS6ST3 NDST2 NDST1 NDST4 NDST3 XYLB GLCE OMD TALDO1 PHKA1 PHKA2 HSPG2 PPP1R3C NHLRC1 HS3ST3A1 SDC4 SDC2 SDC3 SLC35D2 GNS ABO CHST11 CHST12 CHST15 CHST13 ST3GAL6 CHST14 B4GALNT2 PCK2 DERA EXT1 EXT2 B4GAT1 SDC1 PYGB GBE1 STAB2 AKR1B1 PYGM PYGL MAOB KHK GYS2 GYS1 HYAL2 B3GALT2 B3GALT1 MANBA CHST6 CHST7 TPI1 GAA PGAM1 PGAM2 AKR1A1 PGM2L1 B3GNT7 B3GNT4 FAM20B CHST1 B3GNT2 ALDOC ALDOB ALDOA TKT CHST5 CD44 SPAM1 CHST2 CHST3 PAPSS2 RHD PAPSS1 EXTL2 GPC1 HAS1 HAS3 GPC3 SLC17A5 GPC2 HAS2 GPC5 GPC4 EXTL3 GPC6 AGL GLYCTK LYVE1 FMOD AGRN CHPF NAGLU CHP1 SLC26A11 NOSTRIN GYG2 GYG1 CSGALNACT1 EPM2A CSGALNACT2 AKR1E2 KERA PGD SHPK RHCE PFKFB2 PFKFB1 SLC26A2 PFKFB4 CEMIP PFKFB3 SLC26A1 HMMR FUT2 FUT1 FUT4 FUT3 FUT6 FUT5 ASNS TKFC FUT7 FUT9 DSEL PGK2 GCKR SLC37A1 B3GALT4 CA3 PHKB CA7 B3GALT6 CA6 B3GALT5 G6PC2 BPHL G6PC3 CBR3 NOSIP ABCB4 MAN2B2 AADAC UST OGN SLCO1B1 SLC25A28 CRYL1 SLCO1B3 SLC25A37 GLRX5 MAN2B1 HPSE AOC3 GALK1 AOC2 CMBL B4GALT2 MTARC2 ABCD4 B4GALT3 MTARC1 B4GALT1 ADPGK CA12 NQO2 SLC2A1 HK2 CA14 LMBRD1 CA13 SGSH HS2ST1 ALDH3A1 HK1 EPHX1 HK3 CA5B ABCB11 DSE CA5A PGM2 PGLS MAN2C1 SLC37A4 PGM1 HS3ST3B1 CHPF2 DCXR SORD BPGM HKDC1 ALDH1A1 PXYLP1 LALBA B4GALT6 GAPDH B4GALT7 FBP1 FBP2 RBKS B4GALT4 B4GALT5 ST6GALNAC6 PRPS2 PRPS1 GALT RPEL1 RPE PRELP ACAN UGP2 CHSY1 PHKG1 PHKG2 CHSY3 PRPS1L1 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 GALNS RPIA PFKL GALE GNPDA1 PC GNPDA2 GALM PFKM PFKP DTYMK AK1 AK2 AK4 GLRX AK5 ADH4 AK6 AK7 ACSS2 AK8 ALDH2 ALDH1B1 AK9 NUDT13 ADH1C RRM1 ADH1B ADH1A NME3 ADH7 CTPS2 ACSS1 NME4 ADH5 CTPS1 ADH6 DCTD NME6 UCP1 CMPK1 DCTPP1 ELOVL3 CIDEA MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP ADA NT5C AGXT2 PARP6 PARP4 NT5C1A DPYS DPYD PARP16 PARP9 NT5M UPP2 PARP14 PARP8 UPP1 UPB1 PARP10 TYMP PRKG2 AKR1C3 PRKCA PLCB3 CYP26A1 PLCB1 PLCB2 CYP26B1 CYP26C1 RDH11 MAOA PRKAR1A ALDH4A1 PLD3 PRODH PRODH2 AIP SLC23A2 CYB5A CYB5R3 SLC23A1 B3GNT5 VDAC1 OXA1L PI4K2B MTMR2 SACM1L PI4KA SBF1 KGD4 INPP5E SLC25A17 CYP11A1 RAB14 NDUFS3 PITPNB SHMT2 PLD1 NDUFA5 HAL AOC1 CARNMT1 UROC1 AMDHD1 HDC CARNS1 LETM1 HNMT FTCD PTGIS TBXAS1 VAPB CYP4F12 CYP8B1 MOGAT3 STARD3 MOGAT2 STARD4 MOGAT1 ABHD5 STAR STARD6 FABP12 GK3 STARD3NL TSPO GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 PLIN3 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 MGLL LPIN3 THRAP3 FAM120B PRKAR2A AKAP5 HSD3B2 CYP11B2 CYP21A2 HSD3B1 HSD17B10 ST6GALNAC5 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CTSA TPH1 SRD5A3 PNMT DDC TH DBH ARF1 M6PR DNM2 HEMK2 NNMT MTRR AHCY GSTO1 MTR MAT1A MAT2B COMT TRMT112 AS3MT MAT2A ADRA2C ADRA2A CACNA1C PIK3R4 PIK3C3 ABCC2 SLCO1A2 WDR26 GLO1 GPT PDHB LDHC RMND5B LDHB LDHA MAEA PDPR RMND5A MPC1 MPC2 PDK4 PDK3 MPC1L NEK1 ME3 DLAT ME2 PDK2 PDK1 PDHX PDHA2 FAHD1 PDHA1 SIRT4 ARMC8 PDP1 MKLN1 GID4 PDP2 GID8 LDHAL6A LDHAL6B TTR PRSS3 CES1 ARF3 MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 TPTE2 RUFY1 INPP4A INPP4B PI4K2A VAC14 MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 GDPD3 TPTE GDPD5 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 FIG4 PIKFYVE PI4KB PNPLA6 IPPK NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K1 NUDT3 IP6K3 NUDT4 STXBP1 GSS OCRL GPX4 ALOX12B ALOXE3 CKB SLC2A2 IDI2 MSMO1 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 PLPP6 LTC4S ENTPD1 ENTPD5 ADCY9 PRKAR1B PRKAR2B PLCG2 WASL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 NT5E GGT1 DPEP2 DPEP1 GGT5 ACBD5 INPPL1 PLD4 INPP5B PLCZ1 INPP5D INPP5J PLCE1 ITPK1 ITPKB ITPKC PLCB4 SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PM20D1 ECI1 ACADM DECR1 ACSL1 PEX11A CIDEC ELOVL5 THRSP PNPLA2 HSD3B7 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 PSMD8 CYP7A1 PSMD6 CYP27A1 TCN2 PSMD7 PSMD2 PSMD3 PSMD1 ALAS2 ALAS1 PSMA5 FECH COX15 PSMA6 UROS PSMA3 PSMA4 CPOX PPOX PSMA1 ALAD PSMA2 UROD UBA52 HMBS COX10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB ECSIT PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ACSM1 ACSM2B PIAS4 UBE2I VDR NR1H2 RORA CPT1A RXRA SCD5 SUMO2 PPARG PPARA AGK RTEL1 LRAT BRIP1 POLD1 RBP4 RBP2 RBP1 RETSAT RAP1A MAPKAPK2 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC46A1 HDAC3 SMARCD3 CHD9 NPAS2 HELZ2 TGS1 HMOX1 EP300 TBL1X APOB PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 TBL1XR1 CARM1 BMAL1 CLOCK LRP1 CALM1 LRP8 AWAT2 BCO2 BCO1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 NUDT16 ADPRM NUDT5 GLP1R GNGT1 GNGT2 APOM GNG10 GNG3 GNG2 GNG5 AKR1B10 GNG4 GNG7 GNG8 CYP2U1 CYP4F2 CYP4A11 CYP1B1 GCGR GCG NCOA3 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 HSD17B1 IDUA HEXB NCAN HEXA BGN DCN GLB1L3 GLB1L2 BCAN VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 CSPG5 IDS CSPG4 GUSB ARSB RANBP9 NUP107 HADHB PPP1CC HADHA PPP2R1B PPP2R1A ACADL GLUL CACNA2D2 SLC6A11 ACHE NUP160 LRP10 NUP85 LRP12 BCHE RPS27 CACNB2 CACNB3 SEC13 NUP133 CHAT CYP4V2 CACNA1A CACNA1E PPP2R5D TSPOAP1 PPP2CA PPP2CB NUP43 RANBP2 HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 OCA2 SLC45A2 DCT TYRP1 TYR HACD1 TECR NUP37 HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 PTDSS2 ACSL5 PTDSS1 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 MBOAT7 MIOX ISYNA1 INPP1 INPP5A IMPA1 IMPA2 PLA2G4A ERCC2 FDX1 FDXR FDX2 AKT1 LGMN PRKAB2 CSNK2A1 CSNK2A2 CSNK2B TRIB3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion EZH2 FURIN H2AX PCSK6 ANK3 MDM2 H3-3B H3C8 MTBP ZC3H12A CSNK2A3 H2AJ SRC CTNND1 CDH1 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RB1 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 MAPK3 FOXQ1 H2AB1 TLE1 ZBTB33 POMT2 CTSL H2AC8 H2AC6 PKM H2AC7 DNM2 MYCN TMEM258 POMT1 CDH19 SEC11A KLF9 MCRIP1 SEC11C FOXJ2 STRAP FOXP2 OST4 SP1 OSTC STT3A ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 SPCS3 H2BC13 SPCS2 H2BC14 SPCS1 H2BC15 DAD1 HDAC2 H2BC11 JUP SIRT1 TCF3 PSMD8 RBBP4 CANX PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 PSMD1 H2AZ2 KMT5A TGIF2 KLF4 TNRC6C PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 PSMA7 TWIST2 TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC ANGPTL4 ARHGAP32 PSMB1 RPS27A ADRM1 SEM1 HEYL PSMC5 SOX10 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 PRDM8 BHLHE22 KDM1A CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 H4C9 SNAI1 VCL MOV10 AGO3 AGO4 H2AC20 AGO1 ZNF217 AGO2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACADS HADHB HADHA ACADM ACADL ACADVL ECHS1 MECR ACSM3 ACSM6 HADH SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis DDC TPH2 ASMT AANAT TPH1 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c ALG6 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD CSPG5 CSPG4 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN DCN GPC6 BCAN VCAN B3GAT3 AGRN PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 DOK1 ARAP1 PTK6 UBB UBA52 UBC AKT1 RPS27A CBL ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 CTDP1 POLR2A POLR2B SUPT4H1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass UBE2L6 SPRTN TRIM25 VCP UBA52 POLK POLE POLH RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 ISG15 RPS27A RCHY1 UBA7 NPLOC4 RBX1 PCNA POLD3 POLD4 POLD1 POLD2 WDR48 USP1 UBE2B UFD1 CUL4A RPA1 DDB1 RPA2 DTL RAD18 USP10 POLE4 CUL4B REV3L PCLAF POLI RPA3 USP43 POLE2 REV1 POLE3 MAD2L2 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) STAT4 TBX21 NFATC1 IL12RB2 TPST2 CCL3 IFNG RUNX1 TNF RUNX3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 XRCC3 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 LTV1 RPL6 RRP1 RPL7 FCF1 RPS15 PWP2 RPS14 RRP9 RPS17 RPS16 IMP3 RPL18A WDR75 RPS19 IMP4 RPS18 SNU13 RPL36AL RRP7A RPL36 PDCD11 ERI1 RPL35 DHX37 RPL38 PNO1 TBL3 RPL37 LAS1L RPS11 MPHOSPH10 NOL11 NOL12 RPL39 RPS10 WDR46 RPS13 WDR43 RPS12 RIOK2 RPS9 RIOK1 RPL21 UTP14A RPS7 UTP14C RPS8 WDR36 RPL23 TEX10 RPS5 GNL3 RPL22 NIP7 RPS6 RPSA HEATR1 RPL9P9 NOL9 RPL24 NOC4L RPL27 NOL6 RPL26 EXOSC10 RPL29 PES1 CSNK1E RPL28 RRP36 UTP6 RPS4Y2 UTP4 RPS4Y1 RIOK3 RPL39L UTP3 WDR18 RPL41 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 RPL3L FBL RPS26 MTREX RPS25 RPP38 RPS28 RPS27 RPS29 FTSJ3 RPL27A EBNA1BP2 RPS20 RPP21 RPS21 RPP25 RPS24 UTP25 RPS23 ISG20L2 RPLP1 EMG1 UTP20 RPLP0 NOP14 RPP40 RPS4X RCL1 RPL7A RPLP2 RBM28 DDX49 DDX47 RPL13A WDR3 RPS3A NOB1 BUD23 RPL37A PELP1 UTP15 RPL10 UTP11 RPL12 DDX52 RPL11 SENP3 RPL36A UTP18 RPS27L C1D RPS15A DDX21 BMS1 RPL14 RPS3 RPP14 RPL13 DCAF13 RPL15 KRR1 RPS2 RPL18 RPL17 DIS3 RPL19 RPL35A EXOSC7 RPL23A UBA52 EXOSC6 RPL22L1 EXOSC5 FAU EXOSC4 EXOSC9 RPL26L1 EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS27A NOP58 XRN2 NCL CSNK1D NOP56 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions JAK1 HLA-A B2M TUFM IFNB1 YWHAB STAT1 TBK1 IRF3 UBE2V1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 UBE2N YWHAG TAB3 TAB2 PDPK1 TAB1 IRAK1 CREBBP TRAF6 YWHAQ PTPN11 PTPN6 YWHAE BECN1 UVRAG MAP1LC3B YWHAH YWHAZ GJA1 CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 LARP1 IFNA17 SIKE1 MAVS IFNA10 RIGI VPS33A VPS33B G3BP1 G3BP2 HSP90AB1 CNBP NLRP3 SFTPD NLRP12 NUP205 POM121 IL17F IL17A NUP188 AAAS POM121C NUP42 IFNAR1 NUP62 TPR NUP88 RAE1 NUP214 SFN NDC1 NUP210 NUP155 NUP153 NUP93 TYK2 NUP50 NUP35 NUP54 VPS39 STAT2 VPS18 ATG14 VPS11 VPS16 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC SEC23A NUP107 RPS11 SAR1B KPNA2 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 SEC24B SEC24A RPS5 RPS6 RPSA VPS41 VPS45 NUP160 SEC24D SEC24C RPS4Y2 HLA-H RPS4Y1 HLA-C HLA-F NUP85 PIK3R4 HLA-G HLA-E ISG15 RPS26 TOMM70 RPS25 IL17RC RPS28 RPS27 IL17RA RPS29 TLR1 RPS20 TLR2 RPS21 SEC13 RPS24 RPS23 NUP133 PIK3C3 RPS4X HSP90AA1 RPS3A IKBKB RPS27L IKBKG RPS15A MAP3K7 RPS3 CHUK RPS2 NUP43 RANBP2 FAU HLA-B RIPK2 TRAF3 IKBKE RPS27A NUP37 TRIM4 NOD1 NOD2 TJP1 IRAK2 AKT2 TLR8 TLR7 AKT3 AKT1 MASP1 MBL2 IRF7 STING1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT PLK1 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport PRKACG PRKACB AQP6 AQP4 AQP5 AVPR2 AQP2 AQP3 AVP GNGT1 MIP GNGT2 RAB11FIP2 MYO5B ADCY9 PRKAR1B PRKAR2B AQP10 PRKACA AQP12A ADCY4 ADCY3 ADCY2 AQP11 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A RAB11A ADCY5 GNG2 GNG5 GNG4 GNG7 PRKAR1A GNG8 AQP1 AQP8 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 AQP9 GNB3 AQP7 GNB5 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 POFUT2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli FLT4 PANX1 YAP1 CTNNB1 CACNA1H NOS3 RICTOR ABL1 STAT1 CDH5 PPP2R1B PPP2R1A CACNA2D1 SPP1 PRR5 PIK3CD PIK3CB MLST8 CACNB1 CACNB2 PDPK1 CACNB3 ITGB1 PIK3CA IKBKB FYN PKN2 IKBKG MTOR CHUK PPP2CA CALM1 PRKACG PRKACB RELA CAPNS1 CAPNS2 CAPN2 IKBKE NFKB1 NFKBIA KDR ADM GNGT1 GJA1 GNGT2 ADCY9 PRKAR1B PRKAR2B RAMP2 PPP2R2A PIEZO1 PRKACA CALCRL ITGAV ANXA2 MMP14 PTK2 ADCY4 ADCY3 HSPG2 ADCY2 ADCY1 GNAQ ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ADCY5 GNG2 PECAM1 GNG5 GNG4 GNG7 PRKAR1A GNG8 AKT1 CACNG7 ITGB3 MAPKAP1 ITGA5 PIK3R2 P2RY2 GNA11 GNG12 GNG11 GNG13 GNB2 P2RX7 TLN1 PTPN1 VCL GNB1 GNAS GNB4 GNB3 TRPV4 GNB5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency BTD INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes MEFV HMOX1 NLRP1 CASP1 APP NLRP3 PSTPIP1 NLRC4 NFKB2 RELA AIM2 P2RX7 PYCARD BCL2 TXNIP TXN HSP90AB1 SUGT1 BCL2L1 PANX1 NFKB1 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription HEYL NOTCH1 EP300 NOTCH3 RBPJ MAML2 CREBBP MAML1 HEY1 STAT1 KAT2B HEY2 KAT2A MAMLD1 SNW1 PLXND1 WWC1 FABP7 DLGAP5 PTCRA PBX1 HES1 HES5 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 RHOB RHOC LIN7B RTKN RHOA RHPN2 ROPN1 TAX1BP3 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes SREBF1 RETN INS FBXO32 G6PC1 SOD2 FOXO3 IGFBP1 GCK ABCA6 SIN3A TRIM63 FOXO6 NPY FOXO4 PPARGC1A FOXO1 AGRP HDAC1 ATXN3 HDAC2 PCK1 POMC NR3C1 SMAD2 PLXNA4 SMAD4 SMAD3 SIRT3 CAT RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs H2AX PSMA5 GATA3 PSMA6 ITCH PSMA3 GATA2 PSMA4 GATA1 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MYB PSMA7 H3-3B CBFB PSMB6 H3C8 RUNX1 PSMB7 PSMB4 PSMB5 UBB H2AJ PSMB2 PSMB3 UBC PSMB1 YAP1 RPS27A ADRM1 SEM1 H3C15 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LMO1 H2BC9 LMO2 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CCNH TP73 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A CDK7 TCF12 MNAT1 TAL1 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 H2BC17 SPI1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 TCF3 LDB1 H4C9 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 H2AC20 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBA52 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 UBB ANAPC2 UBC MAD2L1 RPS27A NEK2 BUB1B RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid RARA RXRB PPARD PDK4 PDK3 CRABP1 RXRG AKR1C3 DHRS3 DLAT ALDH1A3 CYP26A1 SDR16C5 PDK2 CYP26B1 PDK1 PDHX CYP26C1 PDHA2 DHRS9 CRABP2 RDH11 RARB PDHA1 ALDH1A2 RDH10 RDH16 RDH5 DLD RDH14 RDH13 ALDH8A1 ADH4 ADH1C ADH1A ALDH1A1 FABP5 DHRS4 RXRA RARG PDHB WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis DHRS7B AWAT1 GNPAT FAR1 FAR2 AWAT2 AGPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling PPP1CC SMAD7 TGFBR1 TGFBR2 UBA52 STRAP STUB1 PPP1R15A USP15 MTMR4 UBB TGFB1 PMEPA1 UBC XPO1 RPS27A UCHL5 BAMBI NEDD4L PPP1CB PPP1CA SMAD2 SMAD3 SMURF2 SMURF1 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers DKK2 H2AX DDX46 SMARCB1 DDX42 RBM17 CHD8 MYOG MYOD1 TCF4 H3-3B SMNDC1 U2SURP SMARCC1 SMARCC2 H3C8 H2AJ CTNNB1 H3C15 BICRAL SF3B4 BICRA SF3B5 BRD9 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 H2BC9 SF3A1 H2BC8 SF3A2 H2BC5 ZMYND8 PCK1 PHF5A CHD5 H2BC3 IKZF1 IKZF2 SMARCA2 SMARCA4 PHF6 H2BC1 IKZF3 ZNF687 SNRPN TCF19 ACTL6B ZNF592 ZNF827 CHERP ACTL6A MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 PBRM1 SNRPA1 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 SNRPG SMARCD3 CHD9 SNRPE ARID2 SNRPF MBD3 SNRPB H2BC26 H2BC21 WDR5 EP300 GATAD2B GATAD2A H2BC17 H2BC12 CHD7 H2BC13 H2BC14 FBP1 NKD2 FAM124B H2BC15 SMARCD1 CREBBP HDAC2 SMARCD2 H2BC11 CBX1 TCF3 MAFK CHD4 RBBP4 CHD3 NFE2L2 RBBP7 SMARCE1 H2AZ2 AXIN2 MTA2 CDC73 SUPT16H SKIC8 CTR9 RTF1 CHD2 LEO1 PAF1 SSRP1 MTA1 HDAC1 MTA3 BCL11B PHF10 UBE2I ACTB CBX3 SUMO1 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 G6PC1 SS18 SS18L1 TCF12 ARID1A ARID1B H2AC19 H2AC14 H2BC12L NR2C2 IGF2 BCL11A BRD7 NQO1 ADNP2 ADNP CTCF CHD1 CHD6 DHX15 H4C9 H2AC20 ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation NAT1 NAT2 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants ALK PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling EREG PIK3R1 BTC PIK3CA NRG2 HBEGF NRG3 EGFR NRG4 GAB1 EGF ERBB2 NRG1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R2 CYB5R1 CA1 CYB5R4 CA2 HBB CA4 SLC4A1 CYB5RL RHAG AQP1 HBA2 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis FUT2 FUT1 ABO DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 HMGA1 PSIP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination USP8 FZD5 FZD4 WNT3A RSPO3 UBA52 FZD6 RSPO2 FZD8 RSPO1 RSPO4 LRP5 LRP6 ZNRF3 UBB UBC LGR6 LGR5 RNF43 RPS27A LGR4 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 TNRC6A CALM1 TNRC6B PTPN4 GAD1 GAD2 GAMT PVALB GRIA2 FKBP5 SGK1 FOXG1 MET HDAC1 MOBP BDNF GRIN2B CRH PPARG PRKACA DLL1 SLC2A3 HTT NCOR2 OPRM1 CAMK2B CAMK2D HDAC3 CAMK2A PTEN GRIN2A SOX2 SIN3A DGCR8 CAMK4 GPS2 LBR CAMK2G OPRK1 GPRIN1 TBL1X IRAK1 HDAC2 MEF2C RBFOX1 TRPC3 NCOR1 TBL1XR1 HIPK2 PTPN1 MOV10 AGO3 AGO4 AURKB SST AGO1 AGO2 TNRC6C TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) SYT1 VAMP1 VAMP2 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins CYP26B1 CYP26C1 CYP27B1 CYP24A1 CYP26A1 CYP2R1 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines SAT1 PAOX DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MDM2 PSMA7 PSMB6 PSMB7 MTBP PSMB4 BANP PSMB5 UBB PSMB2 PSMB3 SRC UBC CTNND1 PSMB1 RPS27A ADRM1 CDH1 SEM1 CTNNB1 EPS15 PSMC5 CBLL1 PSMC6 PSMC3 PSMC4 PSMC1 RACK1 PSMC2 CTSL DNM2 CTSS CTSB CTNNA1 JUP PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle SIRT5 SLC25A15 ARG2 CPS1 ARG1 ASL TP53 NAGS ASS1 SLC25A2 NMRAL1 OTC ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus JAG2 JAG1 ITCH ADAM10 DTX4 DLL1 MIB1 DLL4 NEURL1B UBA52 ADAM17 NEURL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B CNTN1 NOTCH1 ARRB1 ARRB2 DNER DTX1 NUMB DTX2 DLK1 MIB2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes H2AC6 H2AC7 H2AX PLK1 CCNB1 H3-3B H2AC19 NCAPH2 CDK1 NCAPG2 H2AC14 H3C8 H2BC12L NCAPD3 SMC4 H2AJ SMC2 H2BC26 H2BC21 MCPH1 H3C15 H2BC17 RB1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 SET H2AB1 H2AZ2 H2AC20 KMT5A H2AC8 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration MMP13 CBFB ITGBL1 AKT2 ITGA5 AKT3 AKT1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies HMGCS2 HMGCLL1 AACS ACAT1 HMGCL ACSS3 BDH2 BDH1 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs POM121C NUP42 NUP62 NUP43 TPR BANF1 NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA ZNF473 SNRPD3 NCBP1 SNRPG NCBP2 CPSF1 CSTF3 CPSF4 SNRPE CPSF3 CSTF2 CPSF2 SNRPF CSTF2T WDR33 SNRPB NUDT21 PCF11 CLP1 CSTF1 FIP1L1 PAPOLA SYMPK CPSF7 LSM10 SLBP LSM11 PABPN1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2AC6 H2AC7 H2AX MTA2 H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ MBD3 H2BC26 H2BC21 TTF1 ERCC6 H3C15 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 MTA1 H2BC15 HDAC1 HDAC2 EHMT2 MTA3 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AB1 H2AZ2 H2AC20 CBX3 H2AC8 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase ADCY1 ADCY8 PRKAR2B PRKAR2A CALM1 PRKACA PRKACG PRKAR1A PRKACB PRKX PRKAR1B CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT NFATC3 NFATC2 NFATC1 FKBP1A CALM1 PPP3CA PPP3CB PPIA PPP3R1 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) HTRA2 DNAJA1 HSPA9 LONP1 HSF1 DEFA5 SOD2 FOXO3 HSPA1A HSPA1B HSPE1 ESR1 ATF5 HSPD1 AKT1 SIRT3 NRF1 CAT DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 CASP8 TNFRSF10B TNFRSF10A TNFSF10 FAS FASLG TRAF2 RIPK1 FADD TRADD ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling PTK6 EGF EREG BTC ERBB2 NRG1 NRG2 HBEGF NRG3 NRG4 EGFR INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling HLA-DRB3 FCGR1BP PTPN6 HLA-DRB1 CIITA OASL CD44 TRIM68 GBP1 TRIM62 OAS1 OAS3 TRIM21 IRF8 IRF6 IFNGR1 IRF9 IFNGR2 TRIM46 TRIM48 JAK1 HLA-B GBP3 HLA-A TRIM45 B2M HLA-DPA1 TRIM35 TRIM38 TRIM31 TRIM34 HLA-DQB2 HLA-DQB1 IRF5 SOCS3 SP100 MAPK1 NCAM1 MAPK3 HLA-DPB1 PIAS1 PTAFR SUMO1 SMAD7 TRIM25 IRF3 GBP6 YBX1 PRKCD IRF4 CAMK2B CAMK2D CAMK2A HLA-DRA IFI30 HLA-H IFNG HLA-C ICAM1 HLA-F TRIM29 TRIM26 HLA-G TRIM22 HLA-E GBP5 GBP7 CAMK2G TRIM17 TRIM14 TRIM10 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 SOCS1 JAK2 IRF1 IRF2 HLA-DQA2 HLA-DRB5 IRF7 MID1 FCGR1A OAS2 HLA-DRB4 MT2A VCAM1 RAF1 GBP2 GBP4 PTPN1 PTPN11 PML GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport TMED2 ARF4 ACTR1A SEC22B RAB1A TMED10 COPZ2 COPZ1 GALNT2 RAB1B KIF4B KIF4A KIF20A KDELR3 KLC1 KLC4 KLC3 DCTN1 KLC2 KIF11 KIF15 AGPAT3 ARF1 KIF23 KIF22 NSF KIF26A DCTN2 DCTN3 DYNC1LI1 DYNC1LI2 ZW10 RAB18 RAB3GAP2 RAB3GAP1 GBF1 TMED3 TMED7 TMED9 KIF18A COPG2 COPG1 COPB2 COPA COPB1 DYNLL1 COPE DYNLL2 ARFGAP1 KIF2A KIF2C KIF2B RACGAP1 PAFAH1B1 DYNC1I2 ARFGAP3 DYNC1I1 NAPA DYNC1H1 NAPB CENPE DCTN6 DCTN5 NAPG DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 RAB6A RAB6B CAPZB CAPZA1 CAPZA2 PLA2G6 GALNT1 ARF5 KIF5C PLA2G4A ARCN1 KIF5B KIF5A KIFAP3 KIF28P KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KDELR2 KIF25 KIF6 KIF27 RINT1 ARFGAP2 KIF9 KIFC2 KIF16B KIFC1 KIF20B KIF3B KDELR1 KIF3A NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF3C ARF3 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation AHCTF1 NUP62 RCC1 NUP43 SEC13 NUP133 NDC1 NUP155 RAN NUP93 RANGAP1 NUP35 UBE2I NUP54 NUP160 KPNB1 NUP85 TNPO1 NUP205 POM121 NUP107 NUP188 NUP37 SUMO1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis GSK3A MAPK1 MAPK3 RNF213 CTSG TRIM27 SFPQ BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism MCCC2 PCCB ACACA MCCC1 BTD PDZD11 HLCS PC SLC5A6 PCCA ACACB MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB7 ABCB6 ABCB10 ABCB8 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN TNKS2 TNKS SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste TAS2R40 TAS2R8 TAS2R41 SCN9A TAS2R43 SCN1B TAS2R46 GRM4 OTOP1 TAS2R1 TAS2R30 CALHM3 PLCB2 TAS2R3 TAS2R31 TAS2R5 TAS2R4 TAS2R38 TAS2R39 SCN3A ITPR3 SCNN1G TAS1R2 SCNN1D TAS2R50 SCNN1B TAS1R1 SCNN1A GRM1 SCN2A TAS1R3 SCN2B KCNJ2 TRPM5 TRPM4 SCN4B GNG13 TAS2R20 GNB1 GNAT3 TAS2R10 CALHM1 TAS2R13 GNB3 TAS2R14 TAS2R7 TAS2R16 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery RPS10 RPS2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 FAU RPS6 RPSA RPS4Y2 RPS4Y1 RPS27A RPS26 RPS25 RPS28 RPS27 HNRNPA1 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS15 RPS14 RPS17 RPS16 RPS19 RPS3A RPS18 RPS27L RPS15A RPS11 EEF1A1 RPS3 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly COX8C SMIM20 COX15 COX5B TIMM21 COX5A RAB5IF COX6C COQ10B COQ10A COX7A2L TMEM177 HIGD1A COX4I1 COX4I2 COX6A1 COX6A2 PET117 PET100 COX6B2 TACO1 COX6B1 MT-CO1 COX16 COX19 COX18 COX17 COX11 COX14 COA3 COA1 HIGD2A COXFA4 COX20 COX7A2 SCO2 COX7A1 TMEM223 COX7B CMC1 COA5 SCO1 MT-CO2 COX7C MT-CO3 COX8A SURF1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function CDKN2A C1QBP PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CRY2 BHLHE40 CRY1 PER2 KMT2A PER1 PER3 SIK1 RBM4 DBP CREBBP CIPC NR1D1 RORA CRTC1 RORC BMAL1 CLOCK NPAS2 TFEB CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHG3 IGHG4 IGHG1 IGHG2 FCN1 FCN2 FCN3 MASP1 MBL2 CRP C1QB C1QA COLEC11 COLEC10 C1S C1R C1QC BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis B3GALT5 ST3GAL3 RHD RHCE ST6GALNAC6 B3GALT2 B3GALT1 FUT2 FUT1 FUT4 FUT3 FUT6 ABO FUT5 FUT7 FUT9 ST3GAL6 B4GALNT2 B3GALT4 ST3GAL4 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence MCM2 TERT BRCA1 LIG1 MCM5 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions IL11 CNTFR CNTF OSMR IL31RA IL31 OSM CTF1 JAK2 CLCF1 IL11RA LIF TYK2 LIFR JAK1 CRLF1 IL6ST SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways DKK1 DKK2 EZH2 DKK4 PYGO1 H2AX PRKAG1 PYGO2 PRKAG2 TMED2 SFRP1 ASH2L SFRP2 CSNK1G2 BCL9L BCL9 CCDC88C PRKAG3 CHD8 USP34 RAC1 CBY1 RSPO2 SOST JAK1 RSPO1 RSPO4 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 CXXC4 FOS LRP6 ZNRF3 VAV1 WIF1 SRY H2AJ SCFD1 RYK LGR6 LGR5 LGR4 YAP1 DERL2 SHB SH2D2A H3C15 NOS3 PAK1 OS9 SPOP RICTOR PAK3 PAK2 KLC1 SUZ12 H2BC9 KLC4 H2BC8 KLC3 H2BC5 KLC2 STAT1 H2BC3 STAT3 MIB2 H2BC1 FOSB CD86 CD80 H2AB1 GRAP2 TLE5 H2AC8 DGKG H2AC6 DGKE H2AC7 DAGLA MYCN DGKD DGKB CD274 DGKA VCP ABHD6 ABHD12 PRKCH PRKCE SEL1L TCF7 DGKZ DGKQ THEM4 DAGLB DGKK DGKI DGKH FGFRL1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 PRR5 RXFP3 RTKN GSK3B SOWAHC PIK3CD DPY30 ARHGEF10L STK10 PIK3CB AKAP13 PIK3CG SLK H2BC26 H2BC21 ARHGEF11 MLST8 ARHGEF10 WDR5 ARHGEF12 YWHAG ARHGEF17 STARD8 EED PDPK1 RHOB CIT H2BC17 DAAM1 ARHGEF3 H2BC12 ARHGEF1 H2BC13 ARHGEF2 H2BC14 PKN3 H2BC15 PIK3CA ARHGEF25 ARHGEF28 LCK IQGAP3 STOM RHPN2 H2BC11 PRKAA1 ECT2 PRKAA2 STARD13 JUP LEF1 CAVIN1 CDC42 PCDH7 MYO9A ERLEC1 NET1 RBBP4 ANLN RBBP5 FYN DIAPH1 ACTC1 CSK RBBP7 DLC1 PKN2 TCF7L2 PKN1 H2AZ2 TCF7L1 ADRA1D ADRA1B PTPN11 MTOR ADRA1A TNRC6C ARHGEF40 GPR176 PLEKHG2 GPR15 GPR27 PTPN6 ARHGEF15 PLEKHG5 GPR25 TNRC6A GPR20 ARHGEF19 TNRC6B GPR32 RHOC TIAM2 GPR45 CCNK OBSCN CCNT2 GPR150 ARHGEF4 GPR83 ARHGEF7 CCNT1 GPR84 NGEF PDE2A ARHGEF6 PPP1R1B FGD1 PDE3A FGD2 CCL4L2 GNA13 NELFB RGS8 FGD3 PDE8B FGD4 PDE8A PCP2 TBXA2R GRK6 GNA12 GPSM1 ARHGEF33 TBP GPSM2 ARHGEF35 ARHGEF37 NCBP1 PDE4A GPSM3 ARHGEF39 NCBP2 ARHGEF38 GTF2A1 PDE4D PLXNB1 GTF2A2 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 PDE7B PDE7A KDR CDK9 PTK6 CHRM2 CHRM3 GJA1 CHRM1 CHRM4 CHRM5 HTR2B ACTB HTR2C ADRB1 ADRB2 HTR2A SCAI HTR4 TAAR3P HRH1 HTR6 HTR7 RGS9 HRH3 RGS6 HRH2 RGS7 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D TP53 HTR1A ARL2 TAAR5 HTR1B ROPN1 TAAR2 HTR5A TAX1BP3 TAAR1 NF2 CCT6A GNAQ PRC1 GPR143 ZDHHC7 ADRB3 CRABP2 ZDHHC21 PPID CAV2 MMP7 UGT1A3 TUBA1B PPP5C CCT2 SPHK1 KDM4A GNA14 CTNNA1 GNA15 GNA11 CCT7 SNAI1 PLXND1 WWC1 DLGAP5 PTCRA PBX1 TACC3 RGS11 FNTA FNTB AAAS RCOR1 JAK3 TYK2 S1PR1 KPNA2 STRAP RPS6 FLT1 LYPLA1 SPPL2B HSPB1 SPPL2A SMPD3 SMPD2 CLIP3 TAX1BP1 TGFB1 NSMAF BAD OTULIN CASP9 ABHD17C USP17L2 ABHD17B ABHD17A RCE1 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 CLTA FMNL3 SPINT1 MST1 HPN HSP90AA1 SPINT2 PARP1 MST1R PGF CDC73 FST FOXH1 DRAP1 CBFB RUNX1 LEO1 ADAM12 IER3 FASN PHLPP2 PHLPP1 ATN1 MAF1 RPS6KB2 WDR83 RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 AXL SHOC2 SEPTIN7 CDC14B RASGEF1A ETV4 IGF2BP1 MAPK6 MAPK4 ANGPT1 TEK SRRM1 DDX39B ANOS1 SOX2 MATK WNT5B ROR1 ROR2 SUFU TRPC7 TRPC6 TRPC3 LAMA5 LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 HHIP BOC GAS1 CDON UBE2D2 PLD2 PRKCQ MEMO1 NRG2 NRG3 RASGRP2 NRG4 RASGRP4 PXN TERT TAB3 DDX4 TAB2 TAB1 GFAP CFTR TRAF6 AXIN2 CCR5 MC4R EDNRB RPS6KA1 MAGED1 SOX9 YWHAH EDN1 EDN3 YWHAZ MC3R KIT RAC2 HDAC1 S100A9 S100A8 MARK3 POMC RHOT1 MC1R ID1 MC5R SNAI2 CAV1 CGA TSHB VAV3 VAV2 CX3CR1 IGF1R HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 MSI2 RHOBTB1 ACTG1 SNX3 RHOBTB2 TRA2B MYO6 STK38 RBBP6 RNF20 SPEN CPSF7 TMOD3 ACTN1 TXNL1 COPS4 COPS2 CDC37 PHIP PDE5A VIM HNRNPC RBMX DBN1 FURIN PCSK6 PCSK5 TGFBR1 TGFBR2 CAB39L RPTOR STK11 EEF2K STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD AKT1S1 CAB39 EIF4EBP1 PGK1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 ITGB5 LAMTOR4 LAMTOR3 EIF4G1 LAMTOR5 MYLK MYL12B MYH11 APC ANXA1 TPM4 TPM3 RAB4B MYL6 PTPN12 LFNG GPAM ZRANB1 SCD SP1 MUC13 DLG1 DLG3 DLG4 TRADD UBE2L3 CASP8 THBS2 FLOT1 TNFSF10 FLOT2 TRAF2 GALNT3 BIRC2 BIRC3 MUC20 XIAP RIPK1 FADD ELANE TNFRSF10B GZMB TNFRSF10A ITCH NPFFR2 NPFFR1 FAS RGSL1 GRPR BAX STUB1 EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 SAMM50 NTSR2 GPR17 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 QRFP MTX1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR AHCYL1 NPS PROKR1 ATP2A3 PROKR2 ATP2A2 KISS1R ATP2A1 P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 PRKACA F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CAMK2B CASR CAMK2D F2R CAMK2A LTB4R2 UTS2 ITPR1 NTS KNG1 ITPR2 MCHR2 GRK5 ITPR3 TAC3 TAC1 OPN4 NMUR2 NMUR1 CAMK2G MLNR TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 RPS6KA3 P2RY1 RPS6KA2 RGS21 CCK HCRTR2 HCRTR1 KISS1 MAPKAPK5 PTN ZAP70 ALKAL2 ALKAL1 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 AMER1 PHC3 GLI1 KIF7 IL6 MDM2 GPR161 INTU TULP3 CXCL8 FUZ BMI1 ADCY10 RING1 RNF2 MAPK8 MAPK7 CDKN2B ICMT H3-4 NTRK2 DOCK3 BDNF GAB1 FRS3 GRIN2B NTF4 TIAM1 SORCS3 NTF3 PLCG1 EGF BCL2 AREG BCL2L1 C5AR2 C5AR1 JAG2 JAG1 ADAM10 CD19 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 ITSN2 GRK3 PIP5K1C CFLAR C3 C5 PLAT PICALM EPS15L1 EPN1 CTTN ARF6 EVC2 IQCE EFCAB7 EVC DRC4 TRIP10 SLC1A5 KLK3 KLK2 KDM4C IDE DHRS4 ST3GAL4 GOLGA7 ST3GAL3 ZDHHC9 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 CAMK4 NEFL HNRNPA1 MYH9 RBPJ BCAP31 MYL9 GATA3 SFN MMP9 SFPQ COL1A2 HNRNPM HNRNPF HEY1 CASP10 HEY2 DUSP16 PTBP1 PPARD EGFR SPP1 MBD3 HHAT USP9X DISP2 SCUBE2 PTPRK HNRNPH1 GATAD2B LRIG1 FAM83D GATAD2A SKI PAG1 FAM83A SPRY1 UBE2D3 YY1 RHOT2 RAP1GDS1 MFN1 MFN2 MYO19 TRAK2 DOCK7 TNS4 TNS3 MRTFA KMT2B FOXO6 FOXO4 FOXO1 SOCS3 SENP1 PTPN18 PTPN13 PTPN7 PTPN2 TNFRSF10D PIN1 MECOM PTEN ITGA5 SRF STAP2 E2F4 E2F5 PTPN1 SST IL2RA CCL2 TRIM33 CCNC MYOG MYOD1 MYF6 TCF4 MYF5 TGFA RACK1 APOE PCK1 FARP2 SMARCA4 SNW1 CDH5 TLE1 RXRB PARD6B RXRG VEGFA PTPRO MAMLD1 PRDM1 EGR1 IRAK1 IL2 IL3 BMP2 TCF3 ULK3 DZIP1 CHD4 CHD3 SPOPL YWHAQ TGIF1 TGIF2 INS MTA2 REST KRAS MAML2 MAML1 SERPINE1 MYB PIP4K2A PIP4K2B JUNB RNF111 NEDD4L GGA3 TIAL1 TIA1 RBFOX2 ESRP2 RAB4A RET RARG ULK1 GLI3 GLI2 RSPO3 TCF12 NCOR2 KAT2B UACA KAT2A RARB IRS4 IGF2 IGF1 GPS2 WWOX SYVN1 WWP1 KDM3A KDM1B APOD ARL4C EEPD1 MRGPRD PTPRJ CMKLR1 PF4 PDYN AGTR2 FPR1 CSF2 FPR3 GALR3 GALR2 ITGA2B GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR MEN1 CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 USP7 PLPPR4 PLPPR5 CCL19 USP2 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 FKBP5 GPHB5 CXCL13 NOTCH2 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A NOTCH3 MTNR1B PSAP CXCL10 CXCL11 NOTCH4 ECE1 ECE2 PRLHR ADORA2A ABL1 CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN TAS2R20 SKIL RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 KEL TAS2R40 TAS2R41 TAS2R42 CDK8 TAS2R43 LHB TAS2R45 TAS2R46 NLN MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP TAS2R38 TAS2R39 TAS2R60 PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 SIN3A CCR4 CCR3 OXGR1 LBR CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 HDAC5 CXCR5 CXCR6 HDAC2 CXCR1 NPW CXCR3 CXCR2 PRLH HDAC8 MAS1 HDAC9 XK HDAC6 NPY2R HDAC7 CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 PML CXCL6 TAS2R9 CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 CXCL5 HDAC10 HEBP1 GRM3 HDAC11 GRM2 GRM4 GRM7 GRM6 GPER1 GRM8 RUNX3 TAS2R1 TAS2R3 TAS2R5 TAS2R4 PTGIR NPY5R SSTR1 SSTR2 SSTR4 AATF SSTR5 CORT CITED1 NPY4R OPRL1 CNR2 CNR1 PRDM4 TAS1R2 S1PR3 TAS1R1 PRMT1 S1PR2 S1PR5 TAS1R3 SGK1 S1PR4 TSHR ACKR4 NPY ACKR3 ACKR2 ACKR1 STEAP3 ATP1B4 KCTD6 CAPZB SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMURF1 TIMP2 SMAD6 TIMP1 ESR2 HELLS SMAD7 TGFB2 NR4A1 INHBA KLF16 ACVR2A TGFBR3 MMP14 MMP16 GIPC1 NR2E1 INHA YBX1 CASP2 AXIN1 OPRM1 PPP1R15A USP15 RBL1 LTBP4 LTBP2 LTBP3 MTMR4 LTBP1 ITGB8 THBS1 PMEPA1 ITGB6 ERBB2 HES1 TGFB3 UCHL5 BAMBI ITGA8 USP8 OPRK1 PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 PORCN ARRB2 KHDRBS1 RAP1B JAK2 KHDRBS2 KHDRBS3 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 VCL MAP3K11 DNAJB1 BAG4 TFRC TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A NEDD8 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 TBK1 DTX4 EPO DBT DLD STK4 SAV1 STK3 LATS1 MOB1B MOB1A LATS2 AMOTL2 AMOTL1 LTK TNK2 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 PELP1 COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 AP2A1 AP2A2 TNF PRKACG PRKACB AP2M1 MYLIP TNFRSF1A FCER2 SPARC ANGPTL3 ABCG1 CETP PDGFB AP2S1 ABCA1 APOC4 NR1H3 AP2B1 APOC2 APOC1 P4HB RAPGEF3 RAPGEF4 VEGFB VEGFC VEGFD CFL1 PLG ST3GAL6 AAMP BCAR1 GRB7 STMN2 KIF14 RND1 STIP1 EPSTI1 WDR6 PLXNA1 FAM83B ANKRD26 DST RRAS2 ALDH3A2 TMEM59 CCDC88A FAM135A VANGL2 UBXN11 DLG5 CPD PKP4 GPC5 B4GALT1 WLS PDGFD CILP MXD4 VPS29 VPS35 CSN2 TMED5 THBS4 THBS3 STMN1 ALDH1A1 VPS26A ADAP1 BEX3 ARHGAP39 SRGAP3 LIMK2 SRGAP2 LIMK1 SRGAP1 MYH14 MYH10 IKBKE OPTN ADH4 ADH1C ADH1A FLT3LG MTA1 MTA3 DNER TLE4 TLE2 DTX1 DTX2 DLK1 RNF31 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 ABCG8 ABCG5 GSK3A GNAT2 CRABP1 PRKG2 PRKG1 AKR1C3 PRKCA DHRS3 ALDH1A3 PLCB3 CYP26A1 PLCB1 PLCB2 SDR16C5 CYP26B1 NLK CYP26C1 PDE6B DHRS9 PDE6A RDH11 PDE6G GNAO1 ALDH1A2 RDH10 RDH16 ALK RDH5 RDH14 RDH13 PRKAR1A ALDH8A1 STRN ARHGAP10 PPP3CC IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA RAG2 RAG1 CSNK1E CSNK1A1 ARHGEF18 CGN F11R PRKCZ RHOA PARD6A PARD3 GFRA1 OPN1SW RPS6KA5 GDNF ARL13B ID4 PDE6D ITGB1 CYFIP1 DOCK5 ANKLE2 SRMS DOCK4 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 ACVR1C RHOG VRK2 LEMD3 ACVR1B ARFGAP3 ACVR2B DEPDC1B CER1 NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 SALL4 RAB7A EPHA2 VAMP3 ARHGEF26 GARRE1 PPP1R12A SHMT2 PPP1R12B PLD1 PPP1R14A IQGAP2 KALRN ARHGAP21 LMAN1 STX5 YKT6 PTPRZ1 PAK4 NDUFA5 MCF2 MCAM ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 PPP1CB ABCD3 PPP1CA FABP5 FABP6 FABP7 PLIN3 PLIN1 MGLL ITGAV PTK2 EGR2 PFN1 PFN2 LEP FLRT3 PRKAR2A NRP1 CXCR4 SOX17 PAK6 PAK5 MYO9B ABL2 CXCL12 NCK2 NCK1 EVL SOS2 MMP2 RFNG POGLUT1 POFUT1 MFNG FLT4 MDK ACTA2 LINGO1 MAG OMG RTN4 NAB1 NAB2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 LYL1 F3 VGF ELK1 ASCL1 EREG CDK5R2 UHMK1 BTC EPGN HBEGF NGFR SQSTM1 CLTB DNM2 SOCS6 MTR ADRA2C ADRA2B ADRA2A KLB IRS1 PDE3B PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 MKNK1 FGF18 SPRY2 HGFAC TLR9 PIK3C3 FGFR4 FGF10 ITGA3 ITGA2 IL6R PDHB PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 RBCK1 PDHA1 PDGFRB TRAT1 NTRK3 PIK3AP1 PTPRU SH2B3 SH2B2 CMA1 FER TEC SH3RF1 FES GRAP LRRC41 NEDD4 RANBP10 KIF5B KIF5A CRHR2 RNF41 CUL5 INHBB SOCS1 MKRN1 UBE2M MTMR1 PIP5K1A PIP5K1B VHL EPOR ACVRL1 BMP10 BMPR2 AMHR2 FSTL1 CHRDL1 AMH NOG GDF2 SMAD9 SMAD5 GREM2 ZFYVE16 BMPR1B BMPR1A PTPRS PTPRF HGF FGFBP1 FGFBP2 FGFBP3 CTBP2 CTBP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 ARHGAP6 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 CYBB ARAP3 OCRL CYBA BCR AMIGO2 NOXO1 ARHGAP17 ARHGAP15 ABR RACGAP1 SLITRK3 TNFAIP1 NHS RND3 SLITRK5 NCKAP1L CKB WASF1 SEMA4F WASF2 CKAP4 IL32 NISCH KCTD13 GIT2 CDC14A ARHGAP26 BAIAP2 TAOK3 ABI2 NOXA1 ABI1 NOX3 NOX1 FERMT2 C1QBP DNMT1 PDGFRA PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL ELMO1 RHOU IL33 OPN1MW IL1RL1 PTK2B KLHL12 CYFIP2 WIPF1 HECW1 WIPF2 WDR91 ANKFY1 WIPF3 WDR81 GNAT3 C3AR1 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 ADCY9 PRKAR1B LRRC1 ARHGAP4 BTK GMIP PRKAR2B CDC42EP5 CDC42EP4 PLCG2 CDC42EP3 ARPC1B CDC42EP2 ARPC1A FGD5 WASL CHN2 CHN1 SYK FARP1 GNAI3 DEF6 ADCY4 WDR11 VMA22 WAS SHKBP1 ADCY3 GOPC PRKX ADCY2 FILIP1 ADCY1 FAM13B ADCY8 FAM13A POTEE ADCY7 ADCY6 GOLGA8R GNAI1 RALGAPA1 ADCY5 FAM91A1 GNAI2 TEX2 ARMCX3 DDRGK1 NSFL1C ARHGAP11A ZNF512B CYSLTR1 ARHGAP11B TAGAP CYSLTR2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 GNAZ BLTP3B NCKIPSD DVL1 SH3BP1 WHAMM DVL2 DVL3 GOLGA3 BAIAP2L2 SPATA13 ARPC4 TMEM87A ARPC5 FAF2 ARPC2 AKAP12 ARPC3 HINT2 SH3PXD2A RHOH ACTR3 RHOF ACTR2 RHOD RHOV PLEKHG4B ADORA2B EMC3 PRAG1 WASF3 SYDE2 ARHGAP44 DOCK11 ARHGAP40 BASP1 RALBP1 KCTD3 PREX2 ARHGAP45 TRIM27 ARHGAP19 ARHGAP18 USP13 TOR1AIP1 TNKS TNKS2 ARHGAP12 WWP2 ARHGAP22 RNF146 ARHGAP20 FRK RHPN1 OTUD3 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 IL2RG ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 PLCB4 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 GPNMB LRRK2 PRKCG GABRG3 GABRG2 LIN7B GNAL NBEA GABRB3 GABRB2 GABRB1 RASGRF2 RASGRF1 NRG1 ARHGEF9 CAMKK1 CAMKK2 GABRQ GABRA1 GABBR2 GABBR1 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 DUSP10 DUSP5 PSMD3 DUSP2 PSMD1 DUSP1 IKBKG BTRC PAQR3 DUSP8 MAP3K7 DUSP9 SKP1 PTPN3 CHUK PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PRICKLE1 PSMD11 PSMD14 PSMD13 PRKCI CUL1 RIPK2 PSMA7 MYD88 RELA RHO PSMB6 PSMB7 PSMB4 GNAT1 PSMB5 ATF1 UBB PSMB2 PSMB3 UBC PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 IRAK4 SEM1 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTPRA HDAC4 NR1H2 ARTN S100B NR3C1 GFRA3 SAA1 ESR1 GFRA2 GFRA4 AR RXRA NRTN ESRP1 RARA DOK1 PGR PPARG TRAK1 KAT5 PSPN CHEK1 IFT172 CCP110 CEP97 DYNC2H1 RPGRIP1L IFT88 MCHR1 KIF3A TTC21B NPHP4 IFT122 MKS1 PLK1 UBE2D1 IFT52 CDK1 IFT57 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 HGS OFD1 CTNNB1 EPS15 MET STAM2 IFT140 SH3GL2 SH3GL1 RALA SHC2 RALB SHC3 SHC1 YWHAB CRKL NRAS SSTR3 RAP1A WDR35 MAPK1 HRAS RALGDS MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK ATF2 WDR19 HDAC3 XPO1 PGRMC2 NRIP1 EP300 TBL1X MEF2D NCOA1 MED1 NCOA2 CREBBP MEF2C NCOR1 TBL1XR1 CARM1 PPP3CA PPP3CB RASGRP1 RASGRP3 PPP3R1 NFATC1 FKBP1A CALM1 YWHAE APP JUN FASLG CDC25C FOXO3 RHOBTB3 LMNB1 BCL2L11 CDK5 CDK5R1 RAB6A RAB9A RAB9B NOTCH1 RBX1 GLP1R UCN VIPR1 VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP ADGRE2 SHH GNGT2 ADGRE5 UCN3 UCN2 ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP ADCYAP1 SMO CRH IAPP ADCYAP1R1 RAMP2 CALCA RAMP3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 PTHLH CRHR1 FLNA GHRHR WNT6 GNG10 GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 WNT2 CD55 WNT3 WNT4 FZD1 STAT5A WNT10B STAT5B FZD3 WNT10A FZD2 GRB2 FZD5 FZD4 WNT3A PTCH1 FZD7 GCGR FOXA1 WNT7B KDM1A TLE3 FZD6 FKBP4 PTCH2 DDX5 FZD9 SCTR POU2F1 GREB1 FZD8 WNT7A CHD1 GCG CTSD NCOA3 GNG12 NR5A2 GNG11 GNG13 TFF3 ADM2 TFF1 GNB2 KANK1 CXXC5 GHRH GNB1 KDM4B GNAS PTGES3 GNB4 USF2 GNB3 USF1 GNB5 ZNF217 EBAG9 VIP RAMP1 SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 DAB2IP NF1 KBTBD7 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 CNTN1 NRP2 CDKN1A SPTAN1 CDKN1B CCND3 SPTB DNM1 DNM3 CCND1 E2F1 E2F3 NUMB TFDP1 NCAM1 RANBP9 TFDP2 CDK4 CCNE1 CDK2 SIRT6 FLT3 ELF3 ERCC6L NUP107 NOTCH2NLA ZWILCH NOTCH2NLC BUB1B NOTCH2NLB SMC3 FLRT2 CDC20 FLRT1 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RAD21 RCC2 NDC80 ZWINT STAG1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RUVBL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 OXTR AVPR1B AVPR2 OXT AVP AVPR1A DSP TJP1 CASP3 DSG1 DSG2 TJP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PDE1C GTF2F1 PDE1B GTF2F2 PDE1A GRK2 PRKCD PLA2G4A H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B TRIB3 EPAS1 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 FSTL3 PIK3R5 GRB10 INSR LYN WWTR1 YES1 NOTUM H4C9 TRRAP JUND SOX3 FRAT1 MOV10 FRAT2 AGO3 STAT6 SOX6 AGO4 SOX7 H2AC20 SOX4 AGO1 RNF43 AGO2 CTNNBIP1 CD28 SOX13 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures LAMB3 COL9A2 COL6A5 LAMA3 LAMC2 MMP9 LOX COL1A1 LOXL3 COL1A2 LOXL4 PLEC LOXL1 LOXL2 MMP20 CTSV CTSL CD151 MMP13 MMP7 COL18A1 CTSS PXDN COL15A1 CTSB COL11A1 COL11A2 PCOLCE COL10A1 COL27A1 COL24A1 MMP3 COL3A1 COL2A1 COL4A2 ITGB4 COL5A1 COL4A1 COL7A1 COL6A2 BMP1 COL5A3 TLL2 COL4A4 TLL1 COL5A2 COL6A1 ITGA6 COL4A3 COL9A1 COL8A2 COL6A3 COL8A1 COL4A5 COL9A3 COL6A6 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN TNKS2 AXIN2 RNF146 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 AXIN1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMURF2 TNKS POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ10 KCNJ16 KCNJ1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases IFIH1 RNF135 TRIM25 OTUD3 VCP TNIP1 TNIP3 MAVS UBA52 YOD1 TP53 UBE2D1 RNF128 RIGI ZRANB1 RIPK2 CDK1 PTEN TRAF3 UBB RHOA UBC RPS27A OTUD7A TRIM4 NOD1 NOD2 APC OTUD5 TNFAIP3 VCPIP1 OTUD7B TNIP2 ESR1 TRAF6 RIPK1 IKBKG OTUB1 OTUB2 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation ITGA2B SERPINA1 ALDOA SOD1 FN1 F5 F8 PSAP CD9 EGF CLU SERPING1 TF VEGFA PPBP HGF TGFB1 APOA1 LAMP2 PCDH7 PPIA CALM1 APP SERPINE1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 CD109 TAGLN2 NHLRC2 TEX264 STXBP2 PDGFB ENDOD1 A1BG APOH VTI1B RAB27B MANF PROS1 A2M APOOL CALU MAGED2 HRG FERMT3 SERPINA3 HSPA5 ORM1 ECM1 OLA1 CTSW ORM2 SERPINA4 TMSB4X TIMP3 GAS6 ALB QSOX1 AHSG ANXA5 TOR4A CD63 SPP2 LEFTY2 LY6G6F VEGFB VEGFC VEGFD TIMP1 LHFPL2 PCYOX1L TGFB2 F13A1 BRPF3 POTEKP TUBA4A CD36 CFL1 FAM3C ABCC4 APLP2 TMX3 SELENOP SCG3 RARRES2 PFN1 CYRIB SELP FLNA SCCPDH ACTN2 LGALS3BP WDR1 PLEK PHACTR2 CYB5R1 SRGN KNG1 MMRN1 PECAM1 CAP1 ITIH4 IGF2 ITIH3 THBS1 IGF1 PLG TTN TGFB3 CLEC3B CDC37L1 CFD ITGB3 ACTN1 FGB FGA VWF FGG TLN1 VCL PF4 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency OTC OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling PPP2CA PPP2CB CALM1 PRKACG PPP1R1B PRKACB CDK5 PDE4A PLCB4 PDE4D PDE4C GNGT1 PPP1CA POMC MAPK1 GNGT2 GNAT3 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B PPP2R1B PRKAR2B PPP2R1A PRKACA PDE1C PDE1B PDE1A GNAI3 GNAL ADCY4 GRK2 PRKCD PRKCA NBEA PLA2G4A PLCB3 ADCY3 PLCB1 PRKX PLCB2 ADCY2 OPRM1 CAMK2B ADCY1 CAMK2D ADCY8 GNAQ CAMK2A ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 GNG7 PRKAR1A GNG8 CAMK4 CAMK2G CAMKK1 CAMKK2 PPP3CC PPP2R5D GNA14 GNA15 GNA11 GNG12 GNG11 GNG13 GNB2 GNB1 PPP3CA PPP3CB PDYN GNB4 GNB3 GNB5 PPP3R1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification GNAI3 GNA13 PLA2G4A TBXA2R GNAQ GNG10 GNG3 GNAI1 GNG2 GNAI2 GNG5 P2RY12 GNG4 GNG7 GNG8 AAMP GNA14 GNGT1 GNA15 GNA11 P2RY1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNAT3 MAPK14 GNB4 GNB3 GNB5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation UBE2O TPP2 BLMH UBA1 UBE2K UBE2M TRIM71 ANAPC7 RNF14 UBE2C KBTBD13 UFL1 UBE2E1 UBE2Q1 UBE2D1 UBE2Q2 ANAPC10 TRIM69 ANAPC11 UNKL DTX3L CDC23 PJA2 UBE2S PJA1 SEC22B CDC26 TRAF7 CDC27 HLA-A UBE2R2 ERAP2 B2M CDC16 THOP1 ERAP1 TRIM50 ANAPC4 MGRN1 ANAPC5 ASB13 ANAPC1 ASB14 ANAPC2 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 SEC31A RCHY1 PSME1 ASB18 PSME2 FBXL22 ASB15 FBXL21P ASB16 PSMB10 FBXL20 ZNRF1 ZNRF2 PSMB8 HECTD1 PSMB9 HECTD2 HECTD3 ASB10 VHL TRIM41 UBE2D2 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 MIB2 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 CTSV ASB7 TRIM36 CTSL TRIM37 ASB4 ASB5 ASB2 TRIM32 CDC34 ASB3 ASB1 UBE2V1 LY96 NCF1 UBE2N NCF2 NCF4 SNAP23 CYBB CYBA TLR4 FCGR1BP VAMP3 ELOB BECN1 ELOC MYLIP RNF111 RBX1 NEDD4L S100A9 S100A8 FBXO4 FBXO6 FBXW4 BTK FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 ITGAV FBXL3 FBXL5 CUL2 RBBP6 WWP1 FCGR1A CUL3 KBTBD7 ATG14 ITGB5 FZR1 SKP2 SEC23A SAR1B CDC20 VAMP8 SEC24B SEC24A SEC24D SEC24C HLA-H HLA-C HLA-F PIK3R4 HLA-G HLA-E HMGB1 UBE2L3 TLR1 CALR TLR6 TLR2 SEC13 PIK3C3 PDIA3 RNF34 UBE2D3 PSMD8 IKBKB CANX PSMD6 PSMD7 PSMD2 PRKN PSMD3 PSMD1 LRR1 IKBKG CCNF BTRC KEAP1 CBLB SKP1 UBE2L6 CHUK HERC5 DCAF1 FBXW11 HERC4 PSMA5 HERC3 PSMA6 ITCH RNF115 PSMA3 HERC2 PSMA4 RNF114 PSMA1 HERC1 PSMA2 TRIM21 UBA52 FBXO7 STUB1 HERC6 PSMD12 FBXO9 PSMD11 WSB1 PSMD14 FBXO2 PSMD13 RNF123 CUL1 HLA-B RNF126 HECW2 PSMA7 MYD88 RBCK1 CBLL2 TRIM11 PSMB6 ANAPC13 PSMB7 UBE2J2 PSMB4 UBE2J1 PSMB5 RNF213 CD14 UBB RNF217 PSMB2 ATG7 PSMB3 HACE1 UBC SIAH2 PSMB1 SIAH1 RPS27A LNPEP ADRM1 MEX3C UBAC1 SEM1 FBXL8 FBXL4 PSMC5 DZIP3 PSMC6 FBXL7 PSMC3 RNF220 PSMC4 DET1 PSMC1 LRSAM1 PSMC2 SH3RF1 TRIM9 MRC1 TRIM4 TAP2 ARIH2 TAP1 SOCS3 CD207 LRRC41 HSPA5 RNF144B SEC61A2 MRC2 GAN RNF138 SEC61A1 SEC61G RNF130 SEC61B HUWE1 KCTD6 KLHL2 TAPBP STX4 UBE2G1 KLHL3 UBE2B UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 SMURF2 KBTBD8 SPSB4 SMURF1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 S100A1 CD36 RNF19B UBE3A FBXO32 UBE3B TIRAP FBXO21 UBE2Z FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 CTSS TRAIP RNF41 KLHL42 UBE2V2 CUL7 TRIM63 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F FGB UBE2H FGA KLHL25 ZBTB16 GLMN FGG KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 RNF182 UBA3 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen FGG FGB FGA ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors GRIA1 GRIA3 GRIA4 GRIA2 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation PPP2CA PPP2CB PPP2R1B PPP2R1A THEM4 CTLA4 RAC1 MAP3K14 PRR5 AKT2 VAV1 PIK3CD AKT3 PIK3CB AKT1 PIK3CG MLST8 PPP2R5E TRIB3 PAK1 PDPK1 MAPKAP1 RICTOR PIK3R3 PAK3 PIK3R2 PAK2 PPP2R5B PIK3R1 PPP2R5A PIK3CA PPP2R5D PIK3R6 PPP2R5C LCK PIK3R5 LYN CDC42 YES1 CD86 FYN CD80 GRAP2 MAP3K8 MTOR CD28 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation RPS2 EIF2S3 EIF2S2 EIF2S1 FAU EIF4E EIF4B RPS27A EIF4G1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 PABPC1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes CSNK2B CDK1 CCNB2 NCAPD2 SMC4 SMC2 NCAPG NCAPH CCNB1 CSNK2A1 CSNK2A2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking NOS3 NOSIP ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNAI3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 GNAT3 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 ADCY9 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes H2AX ASH2L CCNC PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2C GPAM SCD ADIPOQ HDAC3 PHLDA1 ACSL1 PEX11A DPY30 H2BC26 H2BC21 CIDEC WDR5 EP300 TBL1X H2BC17 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 CREBBP NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 PDK4 ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL LIPE DGAT2 MED30 MED31 KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 ELMO2 DOCK1 RASA1 UBA52 RAC1 SFPQ ARAP1 UBB UBC RPS27A CBL ELMO1 GPNMB LRRK2 PTK6 CDKN1B EREG BTC SOCS3 CCND1 HBEGF NRAS STAT3 HRAS NR3C1 EGF CDK4 CCNE1 CDK2 DOK1 CRK NRG2 NRG3 NRG4 EGFR PXN RHOA AKT1 ERBB2 NRG1 BCAR1 EPAS1 SRMS KHDRBS1 HIF1A KHDRBS2 KHDRBS3 STAP2 ARHGAP35 PELP1 PTPN1 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase KPNA1 H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 LMNB1 CASP7 DBNL GAS2 MAPT ADD1 PLEC CDH1 CTNNB1 SPTAN1 BMX PAK2 DSP APC TJP1 OCLN CASP3 DSG1 PKP1 SATB1 DSG2 DSG3 TJP2 CLSPN GSN PRKCQ PTK2 PRKCD CASP6 STK24 STK26 DNM1L ACIN1 KPNB1 ROCK1 HMGB1 CASP8 DFFB DFFA HMGB2 VIM BIRC2 BCAP31 FNTA FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGB1 FN1 CEACAM1 ITGA5 CEACAM6 CEACAM8 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CHEK2 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK3 MAPK14 MAPK11 CHEK1 CSNK1E CSNK1A1 NEK11 GSK3B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System SERPINA1 H2AX CTSC GNLY CD3G MAGT1 LPO HSPA6 DCD F12 RNASE6 RAC1 KLKB1 RNASE8 RNASE7 H3-3B BPIFA1 BPIFA2 H3C8 FOS BPIFB1 BPIFB4 TCIRG1 BPIFB6 VAV1 FTH1 ATP6V1E1 ATP6V1E2 CD59 ATP6V0B ATP6V1G1 EPPIN ATP6V0E1 ATP6V1G2 CHGA H3C15 KIR2DS4 PAK1 KIR2DS5 TRAPPC1 NOS3 ATP6V1B2 ATP6V0D1 ATP6V0C PAK3 S100A7A ATP6V0D2 FTL PAK2 ITLN1 SIGLEC16 ATP6V1B1 SIGLEC15 H2BC9 ATP6V1A KLRC2 H2BC8 HTN1 H2BC5 HTN3 CAND1 H2BC3 ATP6V0A2 ATP6V1H ACTR1B H2BC1 ATP6V0A4 CTSH ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 H2AB1 GRAP2 MAP3K8 LCN2 H2AC8 H2AC6 H2AC7 ZBP1 TBK1 IRF3 VCP NLRP4 DTX4 PRKCE NFKB2 MAP3K14 STK10 PIK3CB H2BC26 H2BC21 PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA LCK STOM H2BC11 JUP CDC42 FYN DIAPH1 PTPN11 CD4 PTPN6 FCER1G AP2A2 GPR84 PRKACG PRKACB TNFRSF1B NPC2 ACAA1 SLC27A2 BIN2 A1BG A2M HRG SERPINA3 ORM1 ORM2 ACTB QSOX1 AHSG IDH1 CD63 CFL1 TP53 NF2 GNS PECAM1 CCT2 AAMP DERA CDA PYGB PYGL MANBA CCT8 GAA PGAM1 TUBB4B ALDOC ALDOA CD44 DBNL AGL PANX1 GYG1 TKFC GSN MAN2B1 HPSE B4GALT1 KPNB1 HK3 PGM2 TAX1BP1 PGM1 CASP9 ISG15 DEFB103B DEFB105B DEFB129 DEFB128 DEFB131A DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B HSP90AA1 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DNAJC3 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B DEFB108C DEFB130A DEFB130B DEFB4B GALNS PFKL HSPA1A HLA-B LIMK1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE OPTN VNN1 EEA1 PDZD11 TASL RBSN IRF5 PROS1 CD33 SLC15A4 CD300A TNFAIP3 AMPD3 APRT CYLD PNP CD177 RAB27A ATP8A1 CLEC10A CLEC4A CLEC4C CLEC4D ATP11B CLEC4E ATP11A CLEC7A CLEC6A CARD9 PLPP5 PLPP4 PLD3 TRPM2 MIF CNN2 ATP8B4 ATP7A CYB5R3 ANO6 VTN B2M AP1M1 APEH LPCAT1 UBE2D2 IGHV3-23 IGLV AGPAT2 IGLV2-8 IGKV1-16 IGKV1-17 PLD2 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 P2RX1 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DSC1 CDC34 PLA2G2A IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 PLAC8 IGLV1-44 PI3 IGKV3-15 IGKV3-11 V2-8 V1-20 CEACAM1 IGKV2D-40 RHOA IGHV3-11 IGHV3-13 IGKV1D-16 ASAH1 ICAM2 IGLV7-43 IGKV1D-12 ICAM3 RELB IGLV1-51 IGLV2-23 RPS6KA5 CD209 UBE2N TAB3 TAB2 TAB1 IGKV3-20 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 RAB10 V1-7 RAB14 STBD1 V5-1 LAMP2 V1-5 V1-3 IGKV3D-20 V5-6 TRAF6 IGHE IGLV3-19 RHOG IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 ELMO2 IGKC DOCK2 IGLV3-21 DOCK1 IGKV1-39 IGKV1-33 RAB7A V4-6 IGHV3-53 V4-2 IGLC7 V4-1 PLD1 IGKV5-2 IQGAP2 IGKV1-5 IGLC6 PRTN3 VAPA RPS6KA1 AOC1 ATG12 ATG5 RAC2 S100A9 S100A8 DGAT1 FUCA1 FABP5 ITGAM ITGB2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 ITGAX IFIH1 RNF135 TRIM25 IFNA21 CD47 IFNA14 IFNA16 VAV3 IFNA17 ITGAV ANXA2 SIKE1 PTK2 MAVS IFNA10 RIGI NME2 VAV2 RAB5B IMPDH1 RAB5C IMPDH2 CAP1 FCGR3B HSP90AB1 ROCK1 MYO9B ACTG1 BST1 NCK1 OTUD5 KCNAB2 NEU1 CAB39 CTSA LAMTOR2 LAMTOR1 LAMTOR3 RAB3D RAB44 SNAP25 ELK1 RAB37 RAB4B CTSZ COMMD9 COMMD3 TXNDC5 RAB24 HSPA8 DNM2 VAMP8 MLEC MUC12 MUC13 MUC15 PIK3R4 MUCL1 MUC3A MUC5AC MUC3B HMGB1 CFP CASP8 CASP5 CASP4 GAB2 CASP1 TLR9 PIK3C3 MUC1 RIPK3 IL18 TRAF2 MUC2 COPB1 IL1B PELI1 MUC7 MUC4 MUC6 MUC16 MUC17 BIRC2 MUC19 BIRC3 PLAUR MUC5B MUC20 MUC21 SDCBP RIPK1 FADD ELANE UBE2L6 GSDMD MGST1 HERC5 ITCH TRIM21 GSDME FPR2 CPNE1 ARMC8 CPNE3 ATG7 TEC TRIM4 HUWE1 CST3 TTR H2AZ1 F2 LYZ SNAP29 PTAFR TSPAN14 AHCYL1 SEMG1 ART1 DEFA1B PRSS3 NOS1 PRSS2 PRKACA DEFA6 DEFA4 ADA2 DEFA5 DEFA3 HP ANPEP MME ITPR1 ATP6AP2 ITPR2 KNG1 ITPR3 UBA7 UBR4 CD180 LY86 LBP BPI SURF4 SOCS1 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ITK LCP2 TXN LAT2 MAP2K7 MAP2K6 UBA3 UBE2K UBE2M ARSA MAPK9 MAPK8 MAPK7 IFNB1 MAPK10 TCN1 PLCG1 BCL2 CD81 C4BPA C4BPB BCL2L1 CLU SERPING1 CPB2 EEF1A1 CFH TRIM32 C5AR2 C5AR1 EEF2 CFI C6 C7 C9 ADAM10 CD19 C8B C8A C8G CR2 CHRNB4 CD46 CPN2 CPN1 CFHR2 NAPRT CFHR1 CFHR4 CFHR3 CFHR5 PDXK NCKAP1 ALOX5 NCF1 NCF2 NCF4 C3 SNAP23 C4A BRK1 C5 C4B_2 CFB C2 SERPINB6 PLAU MGAM CYBB CYBA TXK CHIT1 NCKAP1L WASF1 WASF2 CKAP4 BAIAP2 ABI2 ABI1 TOLLIP C1QBP SLC2A5 PSEN1 NCSTN HCK MMP25 ELMO1 CEACAM6 CEACAM8 PRKCSH CYFIP2 WIPF1 NOS2 WIPF2 WIPF3 ADAM8 C3AR1 ARHGAP9 BTK MEFV GOLGA7 PLCG2 MYO5A MMP8 ARPC1B ARPC1A WASL CTSG SYK WAS PYCARD LRRC7 IGHG3 IGHG4 IGHG1 IGHG2 OLR1 MYH9 TIFA CEACAM3 ALPK1 NCKIPSD CD58 NLRP3 ARPC4 SIRPA ARPC5 FAF2 ARPC2 PCBP2 ARPC3 PSTPIP1 FCGR3A BST2 SELL ACTR3 CALM3 RHOF ACTR2 TREM1 CALM2 FGR MYH2 FCGR1A WASF3 MYO10 P2RX7 TXNIP FCGR2A MYO1C SUGT1 ARHGAP45 PPIE FRK DDX3X SIRPB1 DYNLT1 PLD4 MMP9 KLRK1 KIR2DS2 MOSPD2 SIGLEC9 NCR2 HVCN1 GDI2 LILRA3 CASP10 HSPA1B LAIR1 CLEC5A RAB31 LILRB2 LILRB3 SIGLEC5 OSCAR CD300E RAB18 CD300LB HLA-H HLA-C KLRD1 HLA-E TOMM70 TLR1 TLR6 TLR2 UBE2D3 PSMD8 IKBKB LTF PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ALAD UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 BCL10 PSMA7 MYD88 RELA MALT1 PSMB6 PSMB7 ACTR10 PSMB4 PAFAH1B2 PSMB5 ATF1 UBB ECSIT PSMB2 PSMB3 NKIRAS1 NKIRAS2 UBC IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 IRAK4 SEM1 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 TLR10 PSMC3 PSMC4 TLR5 LRRC14 PSMC1 PSMC2 USP14 NLRX1 PTPRC PELI3 PELI2 NFKBIB TREM2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 NDUFC2 SIGIRR TYROBP S100A1 CD36 IRAK3 MRE11 TIRAP PIN1 ITGAL SRP14 APAF1 PRDX6 GSTP1 SLCO4C1 ATOX1 PTPN4 UBE2D1 LGALS3 CEP290 CTNNB1 TUBB SLC11A1 NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 CTSV MAPK14 CTSL CTSK MAPK12 MAPK13 MAPK11 PKM MAPKAPK3 MAPKAPK2 SOS1 CRK ARG1 ATF2 FCER1A MS4A2 LY96 HBB CRCP HMOX1 EP300 NLRP1 APOB IRAK1 POLR3GL POLR3A POLR3B POLR3C CREBBP POLR3D MEF2C POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H ILF2 POLR3K TLR4 PPP3CA PPP3CB PPIA RASGRP1 CAT PPP3R1 NFATC3 RETN NFATC2 NFATC1 CALM1 APP JUN HGSNAT CAPN1 RAB6A IST1 IGF2R SLC44A2 RAB9B DHX58 RNF125 TBC1D10C RNF216 FRMPD3 GMFG ADGRE5 ABCA13 PGLYRP1 NHLRC3 MCEMP1 ADGRE3 RNASE3 CDK13 SCAMP1 RNASE2 UNC13D FLG2 PADI2 GPI CRACR2A PRDX4 S100A11 AZU1 PLA2G6 PA2G4 HRNR PIGR SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 PLEKHO2 SERPINB10 GRN SERPINB12 AGA ERP44 LRG1 YPEL5 GHDC TMEM179B EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A S100A7 BRI3 PTPRB NIT2 CD55 FCAR GM2A ACP3 RNASET2 TMBIM1 CANT1 FGL2 PRCP CPPED1 MNDA FOLR3 VPS35L CALML5 C6orf120 KRT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 VAT1 CTSD PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 CYSTM1 PTPRJ GLIPR1 CAMP CD53 FPR1 RAP2C RAP2B DNASE1L1 CSTB PGRMC1 CREG1 ORMDL3 GCA PTGES2 SVIP QPCT CD68 MPO COTL1 ENPP4 OSTF1 CD93 IRAG2 ATAD3B DOK3 ADGRG3 HEXB DPP7 ALDH3B1 GGH DNAJC13 TARM1 DEGS1 MS4A3 TNFAIP6 CRISP3 HEBP2 CHI3L1 GLB1 CLEC12A MVP TMEM30A CMTM6 PDAP1 S100P PTX3 GUSB ARSB GLA SPTAN1 PSAP DNM1 DNM3 ABL1 NFASC PPP2R1B PPP2R1A DYNC1LI1 PPBP DSN1 CCR6 RAB3A CCR2 CR1 CXCR1 PPP2R5D DYNLL1 DNAJC5 CXCR2 NLRC4 PPP2CA PPP2CB CXCL1 DYNC1H1 DSP CASP3 DSG1 ACLY PKP1 POLR2E POLR2F CAPZA1 POLR2H CAPZA2 TIMP2 POLR2K POLR2L SLC2A3 PRKCD CASP2 H2AC19 H2AC14 H2BC12L UNC93B1 TLR8 TLR7 FUCA2 TLR3 BPIFB2 CTSS LGMN CTSB HSP90B1 FCN1 FCN2 FCN3 CSNK2B MASP1 CFD MBL2 CRP C1QB C1QA COLEC11 COLEC10 IQGAP1 C1S PIK3R2 C1R PIK3R1 RAP1B GZMM C1QC FGB CGAS FGA LYN DDX41 PGLYRP4 LRRFIP1 PGLYRP3 FGG AIM2 PGLYRP2 YES1 IRF7 TRIM56 H4C9 PRKDC DHX9 RAF1 NLRC3 REG3A IFI16 REG3G DHX36 VCL STAT6 XRCC6 LTA4H KIR3DS1 XRCC5 H2AC20 LEAP2 TREX1 STING1 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair PCNA LIG1 POLD3 POLD4 POLD1 POLD2 POLB POLE APEX1 RFC5 RFC3 RPA1 RPA2 RFC4 RFC1 POLE4 RFC2 RPA3 POLE2 POLE3 FEN1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition FBXW11 AURKA CEP57 CLASP1 YWHAE CETN2 CEP164 PPP1R12A UBA52 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CCNB1 CUL1 CNTRL CDK1 UBB CEP290 NINL OPTN UBC RPS27A RAB8A OFD1 CPAP PPP1CB TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 BORA HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 CCNB2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 AJUBA ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 BTRC SKP1 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors GP5 F11 GP1BA F9 KNG1 F12 GP9 KLKB1 GP1BB DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation PRIM1 POLA1 POLA2 POLE POLE4 POLE2 PRIM2 POLE3 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism ALDOB GALNS G6PC3 RPIA G6PC1 UBA52 TALDO1 PPP1R3C NHLRC1 IDUA SGSH HGSNAT GNS UBB SLC37A4 UBC GLB1 NAGLU HYAL1 RPS27A DCXR GYG2 IDS GYG1 GUSB EPM2A ARSB GBE1 KHK GYS2 GYS1 GAA SI LCT FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions GJA1 DNM2 CLTB DAB2 CLTCL1 CLTC DNM1 CLTA AP2M1 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT4 VEGFD KDR PGF VEGFB FLT1 VEGFC VEGFA ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase EP300 HSF1 CREBBP FKBP4 HSPA1A HSP90AA1 HSPA1B HSPA1L HSBP1 PTGES3 HSPA2 HSP90AB1 HSPA8 DNAJB1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase POM121C NUP42 NUP62 TPR H2AX BANF1 NUP88 RAE1 NUP214 PLK1 NDC1 NUP210 NUP155 NUP153 NUP93 CCNB1 GORASP1 NUP50 NUP35 NUP54 H3-3B ARPP19 RAB1A NCAPH2 CDK1 NCAPG2 H3C8 ENSA RAB1B NCAPD3 RAB2A H2AJ USO1 CTDNEP1 BLZF1 CNEP1R1 NEK9 MASTL NEK6 GORASP2 NEK7 MCPH1 PPP2R2D H3C15 RB1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 MAPK1 H2BC1 SET H2AB1 NUP107 H2AC8 H2AC6 H2AC7 PPP2R1B PPP2R1A NUP160 CCNB2 NUP85 H2BC26 H2BC21 H2BC17 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 H2BC11 EMD H2AZ2 LEMD3 KMT5A PPP2CA PRKCB PPP2CB NUP43 RANBP2 LMNB1 GOLGA2 SMC4 SMC2 NUP37 VRK1 LEMD2 NUMA1 LPIN1 LPIN2 LPIN3 PRKCA H2AC19 H2AC14 H2BC12L H4C9 NUP205 POM121 H2AC20 NUP188 AAAS SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 XPO1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 PTTG1 SMC1A RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 PSMD8 KIF2C KIF2B PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CLASP1 PSMA4 DYNC1I1 PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 PSMD12 CENPU PSMD11 NDE1 PSMD14 CENPE PSMD13 CENPF CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO UBB CENPP PSMB2 CENPQ PSMB3 SPC24 UBC MAD2L1 PSMB1 CENPS RPS27A NUP37 ADRM1 SPC25 SEM1 ESPL1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions SDC1 ITGB1 ITGB3 TRAPPC4 ITGAV VTN ACTN1 PRKCA ITGB4 ITGA2 SDC4 SDC2 SDC3 ITGA6 TGFB1 THBS1 TNC FGF2 CASK ITGB5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 CYP11B1 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFB2 TGFBR1 TGFBR2 TGFBR3 ARRB1 TGFB1 GIPC1 ARRB2 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis F11 GP1BA PROS1 F5 F8 ADAMTS13 F10 GP9 FGB GP1BB FGA GP5 GGCX VWF FGG TPST2 TPST1 F2 F9 PROC ANO6 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA DBT BCKDHB DLD SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 THEM4 IGF1R KLB IRS1 PDE3B AKT2 PIK3R4 IRS4 IRS2 IGF2 CILP FGF1 IGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins FURIN GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 SOS1 FGF18 FGF10 NRAS HRAS FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol CYP8B1 CYP46A1 CYP39A1 AKR1C3 HSD3B7 SLC27A5 AKR1C1 AKR1D1 AKR1C2 AKR1C4 CYP27A1 AMACR SLC27A2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle PPFIA3 PPFIA2 SNAP25 SYT1 UNC13B CHAT VAMP2 CPLX1 STX1A TSPOAP1 SLC18A3 SLC5A7 RAB3A RIMS1 PPFIA1 PPFIA4 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins AQP10 AQP6 AQP4 AQP5 AQP12A AQP2 AQP3 AQP11 MIP AQP9 AQP7 AQP1 AQP8 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex FURIN FKBP1A CCNK TGFBR1 UBE2M CCNT2 TGFBR2 TRIM33 CCNT1 CCNC UBA52 STUB1 UBE2D1 MEN1 SERPINE1 PPM1A JUNB RNF111 COL1A2 UBB UBC RPS27A ITGB5 CBL NEDD4L CDK9 PPP1CB CDKN2B HDAC1 NEDD8 ATP1B4 PPP1CA MAPK1 TFDP1 MAPK3 SNW1 TFDP2 SKIL SMAD2 SMAD4 SMAD3 SMURF2 SMURF1 PPP1CC SMAD7 TGFB2 CDK8 ITGAV TGFBR3 STRAP YBX1 NCOR2 SP1 PPP1R15A USP15 RBL1 LTBP4 ARHGEF18 LTBP2 LTBP3 CGN F11R MTMR4 MYC PRKCZ LTBP1 ITGB8 RHOA TGFB1 PMEPA1 PARD6A ITGB6 PARD3 TGFB3 XPO1 UCHL5 USP9X BAMBI ITGA8 EP300 SKI ITGB1 ITGB3 E2F4 PARP1 WWTR1 NCOR1 E2F5 UBE2D3 TGIF1 TGIF2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) BTK TLR1 S100A1 TLR6 CD36 TLR2 TIRAP S100A9 S100A8 FGB FGA MYD88 FGG TLR4 LY96 CD14 HMGB1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 JAG2 JAG1 ADAM10 DLL1 DLL4 ADAM17 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism GUSB CD44 SPAM1 STAB2 ABCC5 HAS1 CEMIP HYAL2 HAS3 SLC9A1 SLC17A5 HMMR HEXB HAS2 HEXA LYVE1 HYAL1 HYAL3 CHP1 HYAL4 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1L1 UBIAD1 VKORC1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K GAB1 NTF4 PIK3CA PIK3R1 NTRK2 BDNF GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 CCNB1 GORASP1 GOLGA2 MAPK1 RAB1A CDK1 CCNB2 RAB1B RAB2A USO1 BLZF1 GORASP2 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CDK6 CDK4 CCND3 CCND2 CCND1 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA2D2 GNG10 ADRA2C ADCY6 GNG3 GNAI1 ADRA2A ADCY5 GNG2 GNAI2 CACNA1C GNG5 GNG4 GNG7 GNG8 CACNB2 CACNB3 GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 CACNA1D GNB1 GNB4 GNB3 GNB5 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNA6 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis GSK3A DUSP16 HGS RAB7A KPNA1 CTSG UBA52 SFPQ MAPK1 ATP6V1H RAB5A KPNB1 MAPK3 VPS33B NOS2 PGK1 CORO1A RNF213 UBB UBC ENO1 TRIM27 RPS27A VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V1H ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1E1 ATP6V1A ASAH1 ATP6V0B ATP6V1G1 ATP6V0E1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse ARHGEF12 MYH9 RHOB RHOC MYL12B MYH11 SEMA4D LIMK2 RND1 LIMK1 MYH14 MYH10 PLXNB1 MYL6 RHOA ERBB2 ROCK1 MYL9 ROCK2 ARHGEF11 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants STAT5A STAT5B GAB2 ZMYM2 PIK3R1 PIK3CA STAT1 STAT3 LRRFIP1 BCR CUX1 FGFR1OP2 MYO18A CPSF6 TRIM24 CEP43 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs JAK1 MAPK1 MAPK3 IFNG RAF1 IFNGR1 JAK2 IFNGR2 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis RIPPLY2 DLL3 PSMA5 PSMA6 PSMA3 DLL1 LFNG PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 TBX6 SEM1 NOTCH1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RBPJ PSMC2 LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 EPHA4 PSMD1 HES7 MESP2 MSGN1 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK PCNA UBA52 POLK RFC5 RFC3 RPA1 RPA2 RFC4 UBB RFC1 REV3L RFC2 UBC RPA3 RPS27A REV1 MAD2L2 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events STRA6 RDH12 OPN1LW LRAT RLBP1 OPN1MW TTR NAPEPLD ABCA4 RBP4 RDH5 OPN1SW RBP1 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets PPP2CA RPS6KA5 VRK3 PPP2CB DUSP6 PPP2R1B DUSP7 MAPK7 PPP2R1A ELK1 PPP2R5D MEF2C RPS6KA3 RPS6KA2 MAPK1 RPS6KA1 MAPK3 MAPK14 MEF2A DUSP4 DUSP3 MAPK11 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation CD3G RAC1 VAV1 PAK1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 HSP90AA1 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 LIMK1 ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B CFL1 ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 NF2 IGHG3 IGHG4 IGHG1 HSP90AB1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 ACTR2 MYH2 FCGR1A WASF3 MYO10 FCGR2A MYO1C METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors MCCC2 MCCC1 GSTO2 DHFR2 PRSS1 NADSYN1 FLAD1 CTRB2 CTRB1 SLC5A8 BTD MTHFD1 MTHFD2 MTHFD2L SHMT1 HLCS SLC19A3 PNPO SLC19A1 SLC19A2 CBLIF MTHFR MTHFS TCN1 CD320 MOCS2 MOCS3 QPRT THTPA SLC22A13 NMRK2 RFK NMRK1 CD38 MTHFD1L RNLS TPK1 MOCOS ACACB NMNAT3 ACACA NMNAT2 NMNAT1 ALDH1L1 ALDH1L2 NUDT12 SLC25A51 NNMT FOLR2 MTRR NADK SLC52A2 SLC52A3 GSTO1 SLC52A1 MTR GPHN ABCD4 NADK2 NAPRT ACP5 SLC2A1 AOX1 SLC46A1 SLC25A19 LMBRD1 PDXK NAXE SLC25A32 NAXD LRP2 TCN2 PC SHMT2 LDLRAP1 NAMPT CUBN AMN PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT ABCC1 PARP6 PARP4 PRSS3 PARP16 PARP9 PARP14 PARP8 PARP10 SLC2A3 NT5E BST1 PCCA MMAA DHFR PCCB MMUT SLC23A2 MMAB CYB5A MMACHC MMADHC CYB5R3 SLC23A1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 NUP85 EIF4E NUP37 SEC13 NUP133 SLBP NUP205 POM121 NUP107 NUP188 AAAS TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 TNKS1BP1 PLK3 RGCC CNOT1 CNOT2 TP53 CDC25C CNOT3 NPM1 CNOT10 CNOT8 PLAGL1 CNOT11 CNOT9 CNOT6L BTG2 PLK2 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) SV2C SV2B SV2A VAMP1 VAMP2 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer PTPN6 TFG GZMB TPR FN1 RANBP2 JUN UBA52 IL10RA CCNB1 TYK2 DNMT1 CUL1 MDM2 RRBP1 MCL1 JUNB TWIST1 RNF213 UBB MSN IL22 UBC RPS27A CEBPB SEC31A CARS1 MAPK9 RBX1 MAPK8 RB1 CDKN1A HDAC1 KLC1 DCTN1 SQSTM1 STAT1 TPM4 TPM3 FRS3 MAPK1 STAT3 MAPK3 PLCG1 FRS2 PRF1 FOXM1 EEF1G ICOS ZC3HC1 TP53 RPS6 NPM1 IRF4 PPFIBP1 KIF5B LMO7 ALK IRS1 EML4 PPM1B HIP1 PRKAR1A PIK3CB BCL11A EIF2AK3 IL10 BCL2A1 STRN BIRC6 MYH9 STAT5A GRB2 ATIC PIK3R2 CLTC PIK3CA PIK3R1 WDCP GCC2 ZAP70 VCL MOV10 AGO3 AGO4 AGO1 AGO2 SKP1 TNRC6C MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 STAT3 MET HGF NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects HPRT1 APRT ADA ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System HLA-DRB3 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 DAPP1 CTSC ASH2L CD3G MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 SEC22B TEAD3 ERAP2 H3-3B HLA-DPA1 ERAP1 TEAD4 H3C8 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 YAP1 SEC31A DERL3 DERL1 RAP1GAP2 DERL2 SIPA1 TRBV12-3 H3C15 PAK1 TRBV7-9 OS9 SPOP RICTOR HLA-DOA HLA-DOB PAK3 LAG3 PAK2 KIF20A BRD4 KLC1 SUZ12 H2BC9 KLC4 H2BC8 KLC3 H2BC5 KLC2 STAT1 OSBPL1A KIF11 H2BC3 STAT3 KIF15 CTSO MIB2 ACTR1B H2BC1 TRAV8-4 CTSH HLA-DPB1 CTSF CTSE FOSB KIF23 CD86 KIF22 TUSC3 HLA-DMA CD80 HLA-DMB TRAC RILP H2AB1 CD74 GRAP2 NEK2 KIF26A MAP3K8 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 BTLA THEM4 TNFRSF14 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 MAP3K14 PRR5 GSK3B PIK3CD DPY30 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 LCK IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN CSK RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 TNRC6A AP2A1 TNRC6B AP2A2 PRKACG PRKACB ELOB AP2M1 MYLIP ELOC AP2S1 AP2B1 RAPGEF3 RAPGEF4 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 FBXL3 FBXL5 CD79B CD79A IGHM BLNK IGHD DCTN1 COLEC12 CALR CLTC CLTA CANX BLK HLA-B CD14 MRC1 CD33 HSPA5 CD300A TRPC1 AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 PSME1 PSME2 PSMB10 PSMB8 PSMB9 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 PPL RASGRP2 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ICAM2 IGLV7-43 IGKV1D-12 ICAM3 IGLV1-51 IGLV2-23 CD209 UBE2N TAB2 ITGB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 RAB7A V4-6 VAMP3 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YWHAZ S100A9 S100A8 ITGB2 ICAM4 ICAM5 ITGB7 ITGAV VASP XDH ENAH CUL2 RBBP6 NCK1 EVL CTSA ITGB5 ARF1 SEC23A SAR1B DNM2 VAMP8 SEC24B SEC24A SEC24D SEC24C PIK3R4 HMGB1 UBE2L3 PIK3C3 PRKN LRR1 CCNF KEAP1 CBLB UBE2L6 HERC5 DCAF1 HERC4 HERC3 ITCH RNF115 HERC2 RNF114 HERC1 TRIM21 STUB1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 SIAH2 SIAH1 LNPEP MEX3C TRAT1 UBAC1 PIK3AP1 FBXL8 FBXL4 DZIP3 FBXL7 RNF220 DET1 LRSAM1 SH3RF1 TRIM9 TRIM4 ARIH2 LRRC41 RNF144B GAN RNF138 RNF130 HUWE1 KLHL2 UBE2G1 KLHL3 UBE2B UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 AHCYL1 RLIM TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B PRKACA UBE3A UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A KIF5C FBXW12 STIM1 ORAI2 AREL1 ORAI1 FBXW8 KIF5B UBE2E3 KIF5A FBXO17 UBE4A FBXO15 UBE2E2 ITPR1 LMO7 FBXO10 ITPR2 FBXO11 KLHL41 ITPR3 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 ITK FYB1 FBXO31 KLHL20 ZAP70 LCP2 UBE2W UBOX5 LAT UBE2U CD101 MKRN1 RNF182 UBA3 UBE2O TPP2 BLMH UBA1 UBE2K BTNL9 UBE2M BTNL8 TRIM71 BTN2A2 RNF14 BTN3A1 BTN2A1 KBTBD13 BTN1A1 UFL1 UBE2Q1 BTN3A3 UBE2Q2 BTN3A2 TRIM69 BTNL2 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 VHL TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 PLCG1 ASB9 LNX1 CD81 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 ASB3 ASB1 CD19 NCF1 NCF2 NCF4 C3 SNAP23 CD22 CYBB CYBA RACGAP1 BECN1 CD8B BTK PLCG2 SYK WAS CXADR JAML CD99 FCGR3A SELL TREM1 FCGR1A CD226 CD1D CD1C CD1B INPP5D cd21 CD1A KLRK1 SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 KIR2DS2 ATG14 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 SIGLEC9 NCR1 NCR2 CD200R1 NCR3 HCST LILRA6 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA LAIR1 MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 LILRB2 KIR3DL2 LILRB3 LILRB4 LILRB5 CD40LG SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 SIGLEC5 CD96 OSCAR CD8A KLRF1 CD300E CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM HLA-H HLA-C KLRD1 HLA-F ULBP1 ULBP3 PIANP HLA-G HLA-E KLRG1 CLEC2B FCGR2B CLEC2D TLR1 PAG1 TLR6 TLR2 PDIA3 UBE2D3 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 RIPK2 DCTN5 BCL10 PSMA7 MYD88 DCTN4 RELA MALT1 PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 RAP1GAP PSMC4 PSMC1 PSMC2 PTPRC REL NFKBIE NFKBIB SOCS3 TREM2 TYROBP S100A1 CD36 FBXO32 TIRAP KIFAP3 PTEN ITGAL TRIM63 ITGA4 KIF3B KIF3A KIF3C ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ACTR1A ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SH3KBP1 CDH1 CTNNB1 SH3GL2 YWHAB NRAS RAP1A HRAS PVR CTSV CTSL CTSK DCTN2 SOS1 DCTN3 NECTIN2 IFITM1 IFI30 LY96 ICAM1 EP300 CREBBP VCAM1 TLR4 NFE2L2 PPP3CA PPP3CB PPIA RASGRP1 RASGRP3 PPP3R1 NFATC3 NFATC2 FCGR1BP NFATC1 FKBP1A CALM1 JUN RNF111 RBX1 NEDD4L WWP1 CTSD PTPRJ CUL3 KBTBD7 SPTBN2 KIF4B KIF4A FZR1 DNM1 CCND1 DNM3 SKP2 CDK4 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A PPP2R5E SEC13 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RNF34 DYNLL2 KIF2A KIF2C KIF2B DYNC1I2 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE TAP2 TAP1 CD207 SEC61A2 MRC2 SEC61A1 PTPN22 SEC61G SEC61B KCTD6 TAPBP STX4 CAPZB SMURF2 CAPZA1 CAPZA2 SMURF1 H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 TRBC1 CTSS AKT1 LGMN CTSB ICOSLG PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B TRIB3 ATF3 RPN2 EPAS1 MAPKAP1 RPN1 PIK3R3 PIK3R2 PIK3R1 RAP1B HIF1A PIK3R6 PIK3R5 TRAV29DV5 FGB HLA-DQA2 FGA LYN WWTR1 HLA-DRB5 FGG YES1 H4C9 HLA-DRB4 JUND ERLIN1 RAF1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 CD28 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs ALOX5 PTGS2 ALOX15 ALOX12 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 HEXA SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) CXCL8 SSTR3 C5AR2 C5AR1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 OPN1SW C3 C5 ADRA1D ADRA1B ADRA1A CCR5 APP MC4R TBXA2R EDNRB EDN1 EDN3 MC3R OPN1MW CHRM2 CHRM3 CHRM1 POMC CHRM4 CHRM5 MC1R HTR2B HTR2C ADRB1 MC5R ADRB2 HTR2A HTR4 TAAR3P HRH1 HTR6 C3AR1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 CGA DRD4 DRD5 TSHB HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 CX3CR1 HTR5A TAAR1 GPR143 ADRB3 CXCR4 CYSLTR1 CYSLTR2 CXCL12 ADORA2B MRGPRD CMKLR1 PF4 PDYN AGTR2 FPR1 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 S1PR1 CCL19 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 ECE1 ECE2 ANXA1 PRLHR ADORA2A CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN RRH OXER1 PTGDR GPR37L1 KEL LHB NLN MC2R PENK PPY CCR10 CCR1 PPBP ADRA2C ADRA2B ADRA2A PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY CXCL6 CXCL9 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 GRPR EDNRA PROK2 PROK1 UTS2R GPER1 NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 RHO PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR LPAR5 S1PR3 LPAR6 NMS S1PR2 NMU S1PR5 GNRH2 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY ACKR4 BRS3 AVPR2 ACKR3 OXT ACKR2 GPR132 AVP ACKR1 CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 SAA1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR OPRM1 F2R LTB4R2 UTS2 NTS KNG1 MCHR2 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R OPRK1 MCHR1 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 P2RY6 P2RY2 P2RY1 CCK HCRTR2 HCRTR1 KISS1 SST CCL2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NOS1 LPO MPO TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 NCF1 NCF2 NCF4 NOS3 HVCN1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 RAC2 ATP6V1B1 ATP6V1A SLC11A1 CYBB ATP6V0A2 ATP6V1H CYBA ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 NOS2 ATP6V1F ATP6V1C2 ATP6V0A1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery RPS2 FAU RPS27A RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 GEMIN2 RPSA SNRPD2 SNRPD1 SNRPD3 SNRPG RPS4Y2 GEMIN4 RPS4Y1 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters KMT2A BMAL1 CLOCK CREBBP EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling MYL12A EFNB2 PAK1 EFNB1 EFNB3 EPHB2 ARHGEF7 PAK3 PAK2 NCK2 GIT1 RAC1 EPHB6 EPHB1 FYN EPHB4 EPHB3 SDCBP KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS KERA OGN OMD HEXB PRELP HEXA ACAN GNS GLB1L3 GLB1L2 FMOD GLB1L LUM GLB1 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD2 GAD1 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 AMN CBLIF CUBN TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 KRAS UBA52 MAML2 MAML1 PSMD12 PSMD11 FOXO3 PSMD14 TEAD1 RUNX3 PSMD13 TEAD2 MDM2 TEAD3 PSMA7 CCN2 BCL2L11 CBFB TEAD4 PSMB6 RUNX1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SRC UBC PSMB1 YAP1 RPS27A ADRM1 SEM1 NOTCH1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN2A CCND1 HDAC4 SNW1 SMAD4 SMAD3 SMURF2 SMURF1 JAG1 TCF7 TP53 BRD2 KAT2B KAT2A SPP1 MAMLD1 ITGAL MYC TGFB1 HES1 ITGA4 EP300 RBPJ ZFHX3 CREBBP LEF1 WWTR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TCF7L2 PSMD1 TCF7L1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation FGF9 FGF20 FGF23 GALNT3 FGF16 FGF18 FGF1 FGF2 FGF4 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism SLC27A1 CYP2C19 PTGES2 CYP2C9 CYP2C8 CYP1A2 CYP1A1 HPGDS PTGIS TBXAS1 CYP8B1 LTC4S ABCC1 ALOX15 CYP4F3 CYP4A22 PTGDS EPHX2 PRXL2B CYP4B1 PTGR2 CYP4F22 PTGS1 CYP4F11 CYP4F8 PTGR1 ALOX5AP FAAH2 AWAT1 MAPKAPK2 FAAH PTGES ALOX15B AKR1C3 CBR1 PLA2G4A PON3 PON2 PON1 GGT1 GPX2 DPEP2 ALOX5 DPEP1 PTGS2 CYP2U1 CYP4F2 CYP4A11 GGT5 CYP1B1 GPX1 GPX4 ALOX12B ALOX12 ALOXE3 PTGES3 HPGD LTA4H CYP2J2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling SOS1 PRKCE EREG BTC SHC1 PRKCD PRKCA NRG2 HBEGF NRG3 EGFR NRG4 NRAS HRAS EGF PTPN12 ERBB2 NRG1 MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease PPM1K BCKDHA DBT BCKDHB DLD PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines PAOX DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer SOS1 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF CBL MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters SLC8A1 SLC30A2 SLC39A4 SLC8A2 SLC39A6 SLC30A1 SLC41A2 SLC39A5 SLC41A1 SLC39A8 CALM1 SLC39A7 SLC39A2 SLC9A2 SLC39A1 SLC9A3 SLC39A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC24A1 SLC30A8 SLC24A4 SLC30A5 SLC40A1 HEPH SLC24A2 SLC24A5 SLC24A3 SRI SLC8B1 SLC11A2 SLC8A3 SLC11A1 SLC30A10 SLC39A10 SLC39A14 SLC31A1 CP SLC30A3 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions LYN PTPN6 YES1 ITGB3 PLCG1 PECAM1 ITGAV FYN LCK PTPN11 INPP5D RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR2K POLR2L TBP GTF3C1 GTF3C2 GTF3C3 CRCP GTF3C4 GTF3C5 GTF3C6 BRF1 POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK BTK GNGT1 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling SOD1 VAMP7 SNRPA1 MTAP CFL1 ANXA2 IL12B IL12A GSTO1 SOD2 TALDO1 LMNB1 TYK2 JAK1 GSTA2 IFNG CA1 MSN IL10 PSME2 HNRNPF HSPA9 TCP1 PITPNA RALA SERPINB2 PAK2 AIP MIF RPLP0 RAP1B LCP1 JAK2 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 ARF1 CDC42 PDCD4 P4HB HNRNPA2B1 PPIA CAPZA1 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation HTRA2 MRPS10 LONP1 MRPL32 SLC25A5 SLC25A6 SPG7 MRPS2 ECI1 AFG3L2 SMDT1 YME1L1 PMPCA MICU2 MRPL12 COX5B COX5A NADK2 DBT DLD GLUD1 CHCHD2 OXSM CLPX CLPP ALDH18A1 LDHD IARS2 CS UQCRQ TRIAP1 ACO2 SUCLG2 UQCRC2 TIMM17A PDHB NDUFS3 ALAS1 FECH TIMM22 MDH2 MT-ND6 TIMM9 SHMT2 TIMM10 MT-ND5 MT-ND2 BDH1 MT-ND1 ME2 OXCT1 PDK1 HMGCS2 ACAT1 PDHA1 FH MT-ATP6 ATP5F1A ACAD8 ATP5F1B NDUFA13 ACADSB ALDH2 ALDH1B1 ATP5MG TWNK HSPA9 STAR ATP5PF ATP5PD ECH1 SSBP1 PRELID1 ATP5F1C NDUFV3 HADH ACOT2 NDUFV1 ATP5PO IDH2 IDH3A STARD7 NDUFS1 NDUFB6 PRKACA ARG2 OMA1 OPA1 NDUFA2 COX4I1 HSPD1 MT-CO1 TFAM PCCB HSD17B10 MT-CO2 OGDH SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 MAPK7 MAP2K5 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle PPP6C ACD H2AX PPP6R3 GORASP1 MDM2 MDM4 H3-3B RAB1A H3C8 TERF1 RAB1B TERF2 USO1 H2AJ CCNA2 CCNA1 POT1 TERF2IP ANKRD28 H3C15 CDKN2D CDKN2B CDKN2C CDKN2A KIF20A H2BC9 H3-4 H2BC8 H2BC5 FBXL18 H2BC3 H2BC1 SET KIF23 GAR1 H2AB1 NEK2 H2AC8 H2AC6 CDC6 H2AC7 GSK3B H2BC26 H2BC21 YWHAG DKC1 H2BC17 NHP2 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 NOP10 RBBP4 RBBP7 H2AZ2 CDC14A PHF20 CHEK2 GTSE1 ZNF385A FKBPL COP1 PCBP4 PRIM2 PRIM1 POLA1 HJURP POLA2 RSF1 MIS18BP1 OIP5 CENPW CENPX MIS18A ESCO1 ESCO2 PTK6 LIN54 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B TUBB6 TICRR TUBB3 TUBB1 PRKAR2B TUBA4B TUBA4A TP53 TUBA8 WRAP53 TUBA1C TUBA1B SMARCA5 TUBA1A TUBB2B TUBB2A MDC1 TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 NUP214 SFN NDC1 LIG1 NUP210 SUN2 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SYCP2 SYCP1 ORC5 SYNE2 ORC4 SYNE1 ORC6 SUN1 TEX12 ORC1 MCM8 SMC1B ORC3 SYCE3 ORC2 SYCE2 SYCE1 REC8 NEK9 STAG3 NEK6 SYCP3 NEK7 HMMR KPNB1 PHLDA1 HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 KMT5A BTRC SKP1 PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPO11 TEX15 MSH4 PSMD12 RAN DMC1 PSMD11 MSH5 PSMD14 PSMC3IP PSMD13 CUL1 MND1 MLH3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 OPTN PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 CPAP PSMC5 MAX PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TOP2A PIAS4 UBE2I FOXM1 SUMO1 AKAP9 MRE11 BRCA1 BRCA2 KAT5 EXO1 PRKCA FIRRM CHEK1 NBN PRDM9 CCP110 DSCC1 TOPBP1 RUVBL2 CEP250 SHQ1 POLE PIF1 CDK5RAP2 CHTF8 CTC1 RFC5 CEP135 RFC3 CHTF18 EML4 RMI2 CEP131 STN1 RFC4 CSNK1D TEN1 RFC1 RFC2 RMI1 TOP3A HUS1 RAD51C DNA2 RHNO1 BLM RTEL1 PCNA CEP70 POLD3 POLD4 CEP72 WRN VPS4A BRIP1 CEP192 FIGNL1 POLD1 E2F4 POLD2 CEP76 RBBP8 ATRIP E2F5 CEP78 BARD1 PLK4 E2F6 RPA1 ODF2 RPA2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 RAD1 ATM RAD9B ATR RAD9A ANAPC15 CEP57 ANAPC16 ANAPC7 CETN2 UBE2C PLK1 CEP164 UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A PCM1 CCNB1 CDC23 UBE2S CDC26 CNTRL CDC27 ARPP19 CDC16 NCAPH2 CDK1 NCAPG2 ANAPC4 NIPBL ANAPC5 ENSA ANAPC1 TNPO1 NCAPD3 ANAPC2 RAB2A CEP290 NINL CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL RAB8A GORASP2 OFD1 MCPH1 PPP2R2D TUBB HAUS4 HAUS3 HAUS6 HAUS5 YWHAB TUBG1 HAUS2 MAPK1 HAUS1 CEP63 MAPK14 SFI1 MAPK11 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 NPM1 PCNT CEP152 CSNK1E CSNK1A1 NEK11 NEDD1 TERT ALMS1 CEP41 CEP43 XPO1 UBE2N EP300 ANKLE2 FKBP6 PTTG1 EMD YWHAQ HSPA2 MYBL2 LEMD3 RCC1 AURKA RRM2 YWHAE PPP1R12A CDC25C CDC25A CDC25B LMNB1 GOLGA2 YWHAH SMC4 SPAST SMC2 CC2D1B SIRT2 TUBGCP2 NCAPG TUBB8 NCAPH IST1 VRK1 TUBGCP5 LEMD2 TUBGCP6 TUBB8B TUBGCP3 TUBGCP4 ESPL1 RBX1 NUMA1 YWHAZ TUBG2 MZT2B MZT2A NME7 MZT1 PPP1CB NCAPD2 PLK3 HDAC1 CDC7 LPIN1 LPIN2 LPIN3 PPP2R2A HSP90AB1 FBXO5 DYRK1A DHFR TK1 TYMS PPP2R3B GINS1 GINS2 CDC45 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 ABL1 E2F3 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT LBR STAG1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RUVBL1 RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 BIRC5 CHMP4A KIF2C CHMP6 KIF2B CHMP7 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CHMP2B CLASP1 HERC2 DYNC1I1 CHMP2A CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ GMNN TPX2 SPC24 MAD2L1 CENPS NUP37 CDT1 SPC25 FEN1 MCM10 DBF4 FBXL7 MLH1 RPA4 PKMYT1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E BRCC3 POLR2F POLR2G CLSPN POLR2H TP53BP1 POLR2I BABAM1 POLR2J BABAM2 POLR2K UIMC1 RNF168 POLR2L ABRAXAS1 RNF8 PRKACA NSD2 CDK7 MNAT1 RBL2 H2AC19 RBL1 H2AC14 H2BC12L AKT2 MYC AKT3 AKT1 UBE2V2 CSNK2A1 CSNK2A2 CSNK2B JAK2 LYN H4C9 TINF2 AJUBA H2AC20 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle POM121C NUP42 NUP62 FURIN TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP107 NMT2 NUP160 NUP85 XPO1 SEC13 NUP133 PDCD6IP RANGAP1 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PPIA RCC1 NUP43 NMT1 CCNK CHMP2B RANBP1 CCNT2 CHMP2A ELL CCNT1 RANBP2 GTF2B UBA52 TAF7L ELOA RAN ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 UBB CTDP1 TAF9 SUPT4H1 UBC TAF1L GTF2E1 GTF2E2 RPS27A NUP37 TAF15 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 NEDD4L CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 CHMP5 NUP205 POM121 NUP188 AAAS IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DLD DLST DHTKD1 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition PPP2CA PPP2CB PPP2R1B PPP2R1A PPP2R2A SGO1 PLK1 CDC25C CDC25A CDK7 CCNB1 CDC25B MNAT1 HJURP MIS18BP1 CDK1 CCNB2 CCNA2 CCNA1 XPO1 PKMYT1 FZR1 WEE1 PPME1 BORA OBI1 LCMT1 PPP2R3B CCNH TICRR CDK2 FOXM1 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle RHOT1 RAP1GDS1 TRAK1 MYO19 TRAK2 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation SERPINA1 LAMB2 FN1 F5 LAMB1 LAMC1 MEN1 IGFBP1 IL6 GPC3 IGFBP3 VCAN PDIA6 VGF APOE WFS1 FSTL1 CP CHRDL1 TF ADAM10 MBTPS1 PENK SPP1 CDH2 BMP4 FGF23 C3 APOB C4A APOA1 PNPLA2 DNAJC3 CKAP4 PCSK9 APP CSF1 APOA2 TGOLN2 APOA5 KTN1 CALU SERPINC1 MFGE8 CST3 GAS6 ALB QSOX1 PRKCSH AHSG P4HB PROC TNC SPP2 TIMP1 DMP1 LGALS1 EVA1A CCN1 APLP2 FBN1 CHGB IGFBP5 IGFBP4 SCG3 MGAT4A SHISA5 MXRA8 SPARCL1 SCG2 SDC2 STC2 KNG1 AMELX AMBN LTBP1 TMEM132A FUCA2 BPIFB2 HRC MELTF HSP90B1 SERPINA10 MIA3 MSLN PRSS23 BMP15 MEPE RCN1 ENAM AMTN FAM20C VWA1 FAM20A MATN3 ITIH2 AFP FSTL3 APOL1 FGA SERPIND1 GOLM1 FGG NUCB1 NOTUM IGFBP7 ANO8 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC27A1 CYP2C19 ACBD5 PRKAG2 PTGES2 CYP2C9 CYP2C8 CYP1A2 CYP1A1 HPGDS ECI1 ACADM DECR1 ACOT9 ACOT7 ACOT1 ELOVL6 MCAT PTGDS PRXL2B ACOT7L PTGR2 ACADVL PTGS1 THEM5 FADS2 FAAH2 FADS1 ACACA HADHB HADHA AWAT1 MAPKAPK2 PCTP ACADL SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 PPARD CPT1B PTGES ALOX15B THEM4 CBR1 SCD ACAA2 ACOT11 ACBD4 ACOT12 ACOT13 ACBD7 ACSL1 ACBD6 ACSF2 DBI CPT2 PON3 PON2 PON1 GPX2 ALOX5 PTGS2 ELOVL5 SLC25A17 THRSP PRKAA2 GPX4 ALOX12B ALOX12 ALOXE3 SLC22A5 ACOT8 EHHADH HSD17B4 ACAA1 PECR HACD1 DECR2 TECR ABCD1 PTGIS SLC27A2 TBXAS1 HSD17B3 ACOT4 CROT HSD17B12 HACD3 CYP8B1 SCP2 HACD2 NUDT19 HSD17B8 HACD4 HTD2 FASN PHYH MORC2 CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 ACOX2 ACSL5 ECHS1 ACSM3 ACSL4 ELOVL3 ACSM6 ELOVL7 HADH ACSL3 ACOT2 LTC4S TECRL ACADS ACOX3 ACSF3 ACLY PPT1 HACL1 ACSBG1 PPT2 ABCC1 SLC27A3 ALOX15 HAO2 CPT1A CYP4F3 ACSBG2 EPHX2 CYP4A22 CYP4B1 CYP4F22 CYP4F11 NUDT7 CYP4F8 AMACR PTGR1 RXRA SCD5 ALOX5AP CRAT ACOXL AKR1C3 PLA2G4A PRKAB2 MECR GGT1 DPEP2 DPEP1 CYP2U1 CYP4F2 GGT5 CYP4A11 CYP1B1 MCEE NDUFAB1 PCCA MMAA PCCB MMUT GPX1 PTGES3 HPGD LTA4H CYP2J2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type CSPG5 CSPG4 SDC1 B4GALT7 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN DCN GPC6 BCAN VCAN AGRN REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 CDK2 BUB1B CDC20 FBXO5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation CHUK UBE2V1 APP UBA52 TP53 NFKB2 RIPK2 RELA UBB NKIRAS1 NKIRAS2 UBC IKBIP RPS27A HMGB1 NFKB1 CASP8 NFKBIA UBE2N TIFA TAB3 TAB2 ALPK1 TAB1 IRAK1 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 TRAF2 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B IKBKB SAA1 TRAF6 IKBKG MAP3K7 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization CIDEC HSD17B13 HILPDA CIDEA FITM1 FITM2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity GRIP2 GRIA1 PRKCB AP2A1 EPB41L1 TSPAN7 GRIA3 GRIA4 PRKCA MDM2 CAMK2B CAMK2D CAMK2A DLG1 DLG4 GRIA2 AKAP5 CAMK2G PICK1 CACNG8 MYO6 CACNG2 CACNG3 CACNG4 GRIP1 NSF PRKCG REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6A TNRC6B REST SRF NPAS4 NR3C1 MOV10 AGO3 AGO4 KCNIP3 AGO1 AGO2 TNRC6C PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair PCMT1 MSRA TXN MSRB2 MSRB3 MSRB1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint RAD1 ATM RAD9B H2AX ATR RAD9A YWHAE HERC2 SFN CHEK2 CDC25C CCNB1 CDK1 YWHAH CCNA2 CCNA1 YWHAZ H2BC9 H3-4 YWHAB PIAS4 H2BC8 WEE1 H2BC5 H2BC3 H2BC1 BRCC3 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 H2BC26 TOP3A UBE2V2 H2BC21 HUS1 YWHAG UBE2N DNA2 MDC1 H2BC17 RHNO1 BLM H2BC12 H2BC13 H2BC14 H2BC15 WRN BRIP1 H2BC11 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 YWHAQ RAD50 RPA3 RAD17 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD CBLIF REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate DNA2 PCNA POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RPA1 RPA2 RPA3 FEN1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis NCOR1 NR1H2 FABP6 RXRB NCOA1 UGT1A3 RXRA NR1H3 NCOR2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL OFD1 CPAP TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA TGFA TFAP2A TFAP2B KIT TFAP2C CGB8 EGFR VEGFA ESR1 YY1 ERBB2 ATAD2 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein GSK3A PRMT1 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 PARP10 SRPK2 SRPK1 UBE2I CSNK1A1 GSK3B SUMO1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35C1 SLC35D1 SLC35B4 SLC35D2 SLC35A2 SLC35B3 SLC35B2 SLC35A1 SLC35A3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3L1 CREB3L2 MBTPS2 MBTPS1 CREB3 CREB3L3 DCSTAMP CREBRF CREB3L4 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 PARL AFG3L2 PHB1 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU STOML2 MCUB SPG7 PHB2 MAIP1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma TGFA PLCG1 EGF EREG BTC AREG EPGN HBEGF EGFR PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis GSDMD GZMB CHMP2B CHMP2A CYCS BAX TP53 GSDME HMGB1 CASP5 CASP4 CASP1 TP63 IL18 IL1A IRF1 IL1B IRF2 CASP3 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 BAK1 ELANE BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 GSTT2 CYP1A1 GSTT1 AHRR OPLAH CYP2E1 CNDP2 CYP2F1 HPGDS TPST2 ESD CHAC2 CHAC1 TPST1 GSTT2B GSTM4 CYP24A1 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT GSTA5 GSTA4 GSTM5 PTGS1 CYP19A1 GSS NCOA1 CYP11A1 NCOA2 CYP2R1 AOC1 CES2 CES3 PTGIS TBXAS1 CYP4F12 CYP8B1 GSTK1 POMC PAOX UXS1 GSTM1 TPMT GSTA2 GSTA1 SLC35D2 UGT1A3 HSP90AB1 GGT1 DPEP2 DPEP1 CYP11B2 CYP21A2 CYP2U1 CYP4F2 GGT5 CYP4A11 CYP1B1 MAOB AKR1A1 PTGES3 UGT1A10 ABHD10 UGT2B10 UGT2B11 UGT2B15 ACY1 UGT2B17 SLC35D1 UGT3A2 UGT3A1 NAT1 NAT2 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGDH UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGT1A6 BPHL CBR3 HEMK2 AADAC NNMT MTRR AHCY GSTO1 AOC3 AOC2 MTR CMBL MAT1A CYP51A1 MTARC2 MAT2B MTARC1 COMT TRMT112 AS3MT NQO2 CYB5B MAT2A ALDH3A1 EPHX1 FMO2 FMO3 GLYATL3 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 GLYAT ALDH1A1 CYP4V2 NR1H4 CYP7B1 UGP2 CYP7A1 CYP27A1 ACY3 GGT7 PODXL2 GGT6 ABHD14B MGST3 SULT1A1 MGST1 SULT1C2 MGST2 SULT1B1 FMO1 SULT1E1 AKR7L AKR7A2 BPNT2 AKR7A3 BPNT1 GGT3P SULT6B1 SULT1A4 SULT4A1 SULT1A3 SULT1A2 SULT2A1 SULT1C4 ADH4 ACSS2 ALDH2 ALDH1B1 ADH1C ADH1B ADH1A ADH7 ACSS1 ADH5 ADH6 ARNT2 ACSM1 ACSM2B CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 RXRA CYP26A1 CYP26B1 FDX1 CYP26C1 FDXR FDX2 MAOA CES1 ARNT CYP46A1 CYP39A1 POR CYP27B1 GSTP1 CYP11B1 GSTA3 AIP GCLC GCLM CYB5R3 CYP2J2 CYP3A43 AHR METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins LTF S100A7A S100A7 S100A9 S100A8 LCN2 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels HCN4 HCN3 HCN2 HCN1 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants HRAS KRAS NRAS PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis SLC8A1 SLC8A2 CALM1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 TRPC7 TRPC6 TRPC3 P2RX6 P2RX5 P2RX7 P2RX3 P2RX4 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) CSF3 KRAS SYK UBA52 UBE2D1 ELOB ELOC TYK2 JAK1 UBB RNF7 UBC RPS27A CUL5 STAT5A STAT5B HCK GAB2 GRB2 SOCS3 SOCS1 SHC1 JAK2 UBE2D2 STAT1 LYN STAT3 UBE2D3 CSF3R PTPN11 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases RAC1 FOS TCIRG1 VAV1 ATP6V1E1 ATP6V1E2 ATP6V0B YAP1 ATP6V1G1 ATP6V0E1 ATP6V1G2 SHB SH2D2A ATP6AP1 PAK1 MAPK7 NOS3 ATP6V1B2 ATP6V0D1 RICTOR ATP6V0C ATP6V0D2 PAK3 PAK2 ATP6V1B1 ATP6V1A NTRK2 DOCK3 STAT1 BDNF GAB1 FRS3 STAT3 ATP6V0A2 GRIN2B ATP6V1H NTF4 ATP6V0A4 TIAM1 ATP6V0E2 NTF3 ATP6V1G3 PLCG1 FOSB ATP6V1D ATP6V1C1 EGF ATP6V1F AREG ATP6V1C2 ATP6V0A1 GRAP2 MYCN CD274 ADAM10 PRKCE ADAM17 THEM4 FGFRL1 PTPRS PTPRF HGF PRR5 FGFBP1 FGFBP2 PIK3CB FGFBP3 MLST8 NCKAP1 NCF1 NCF2 NCF4 PDPK1 BRK1 LTK TNK2 PIK3CA PLAT LCK COL4A2 COL4A1 CYBB EPS15L1 COL6A2 JUP CYBA COL4A4 EPN1 CDC42 COL6A1 COL4A3 ARF6 FYN COL9A1 DIAPH1 CSK COL6A3 NCKAP1L PTPN11 COL4A5 WASF1 MTOR COL9A3 WASF2 COL6A6 COL9A2 PTPN6 COL6A5 BAIAP2 AP2A1 ABI2 AP2A2 ABI1 ARHGEF7 PRKACG PRKACB NELFB AP2M1 DNMT1 SPARC PDGFRA NCBP1 NCBP2 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B IDE PDGFB KDR ELMO1 AP2S1 PTK6 AP2B1 PTK2B CYFIP2 VEGFB VEGFC VEGFD PLG AAMP SPHK1 BCAR1 HNRNPA1 CTNNA1 GRB7 WASF3 FAM83B IL2RG JAK3 MMP9 HNRNPM HNRNPF GABRG3 GABRG2 PTBP1 GABRB3 GABRB2 EGFR GABRB1 FLT1 SPP1 HSPB1 PDGFD CILP MXD4 NRG1 CSN2 THBS4 THBS3 STMN1 PTPRK HNRNPH1 LRIG1 ADAP1 FAM83D PAG1 FAM83A SPRY1 CLTC CLTA GABRQ SPINT1 GABRA1 MST1 HPN HSP90AA1 SPINT2 MST1R PTPN3 PRKCB PGF UBA52 ATF1 UBB DOCK7 TNS4 TNS3 UBC MEF2A RPS27A DUSP4 DUSP3 VRK3 DUSP6 ADAM12 DUSP7 FLT3LG AXL S100B PTPN18 ESR1 ESRP1 PGR PTPN2 ANOS1 PRKCA CHEK1 ALK MATK SRF PTPN1 LAMA5 LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 LAMC2 LAMB1 LAMC1 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL HGS CTNNB1 EPS15 MET TGFA STAM2 SH3GL2 SH3GL1 RALA SHC2 RALB SHC3 SHC1 YWHAB CRKL APOE NRAS RAP1A MAPK1 HRAS RALGDS MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 CDH5 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK MEMO1 NRG2 NRG3 NRG4 ATF2 VEGFA PTPRO HDAC3 PXN PRDM1 PRKCZ RHOA RPS6KA5 EP300 TAB2 ID4 ITGB1 EGR1 CYFIP1 MEF2D MEF2C NCOR1 GFAP CHD4 ELMO2 DOCK1 INS CALM1 REST PTPRZ1 JUNB CDK5 RPS6KA1 ERBIN CDK5R1 GGA3 KIT HDAC1 TIAL1 TIA1 RBFOX2 ESRP2 RAB4A ID1 CAV1 ADCYAP1 ADCYAP1R1 VAV3 ITGAV PTK2 EGR2 TCF12 VAV2 IGF1R FLRT3 NRP1 IRS4 IGF2 IGF1 ROCK1 ROCK2 STAT5A STAT5B GRB2 CXCL12 WWOX NCK2 NCK1 WWP1 CDC37 CTSD PTPRJ SPRED2 FURIN SPRED1 PCSK6 PCSK5 RASA1 FLT4 MDK NAB1 NAB2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 NRP2 LYL1 F3 VGF ELK1 ASCL1 EREG CDK5R2 BTC EPGN DNM1 HBEGF DNM3 ADORA2A RAB4B RANBP9 FLT3 PTPN12 FLRT2 FLRT1 DNM2 PPP2R1B PPP2R1A SOCS6 KLB IRS1 DLG4 PDE3B PIK3R4 IRS2 FGF1 SIN3A FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 THBS2 FGF22 GAB2 FGF16 FGF19 MKNK1 FGF18 SPRY2 HGFAC TLR9 PIK3C3 FGFR4 HDAC2 FGF10 PPP2R5D ITGA3 ITGA2 GALNT3 MUC20 PPP2CA PPP2CB ITCH BAX STUB1 PDGFRB NTRK3 PTPRU SH2B3 SGK1 SH2B2 CMA1 FER TEC FES GRAP POLR2A POLR2B POLR2C POLR2D NEDD4 POLR2E AHCYL1 POLR2F POLR2G POLR2H POLR2I RANBP10 POLR2J POLR2K POLR2L PRKACA TGFBR3 GTF2F1 GIPC1 GTF2F2 PRKCD ITPR1 ITPR2 AKT2 MYC ITPR3 AKT3 THBS1 AKT1 RNF41 ERBB2 CUL5 USP8 TRIB3 ITGB3 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 HIF1A RAP1B SOCS1 JAK2 GRB10 INSR LYN RPS6KA3 RPS6KA2 YES1 JUND PTN ALKAL2 STAT6 ALKAL1 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 LAMC2 UBA52 LAMB1 LAMC1 RAC1 UBB SH3GL3 DOCK7 SH3KBP1 TNS4 TNS3 SRC UBC RPS27A STAM CBL HGS EPS15 MET STAM2 SH3GL2 SH3GL1 GGA3 CRKL NRAS GAB1 RAP1A RAB4B STAT3 HRAS RAB4A RANBP9 RANBP10 PTPN2 RAPGEF1 SOS1 CRK PTK2 HGF USP8 LRIG1 ITGB1 HGFAC PIK3CA PIK3R1 RAP1B ITGA3 SPINT1 ITGA2 HPN SPINT2 ARF6 PTPN1 PTPRJ MUC20 PTPN11 LAMA5 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 FRS3 HRAS NTF4 SOS1 FRS2 NTRK2 PTPN11 NRAS BDNF INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane GET4 CAMLG HMOX1 APP PRNP VAMP2 STX1A UBL4A BAG6 SEC61G STX5 SGTA SEC61B VAPA EMD OTOF GET1 SERP1 GET3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere ACD PRIM2 DSCC1 PRIM1 POLA1 POLA2 CHTF8 RFC5 CTC1 CHTF18 RFC3 STN1 RFC4 TERF1 TEN1 RFC1 TERF2 RFC2 POT1 TERF2IP PCNA POLD3 POLD4 POLD1 POLD2 TINF2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCND1 PSMD8 PSMD6 CDK4 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia IVD RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription HSPA8 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA3 CA7 CA9 CA14 CA6 CA13 CA5B CA1 CA5A CA2 CA4 CA12 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion INMT BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME CYP2C19 ITPA CYP3A4 CYP2C9 CYP2C8 CYP2D6 RAC1 GSTT1 CNDP2 CYP2E1 VAV1 UGT1A10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 ACY1 UGT3A2 UGT3A1 NAT1 NAT2 UGT2A3 UGT2A2 ABCG2 UGT2A1 UGT1A1 UGT2B4 UGT2B7 PCK1 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGT1A6 BSG SLCO1B1 SLCO1B3 SLC22A2 SLC22A1 HSD11B1 SLC29A3 HSD11B2 SERPINA6 SLC16A1 PON3 BCHE GLYATL3 PON1 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 GLYAT ABCC2 AKR1C1 SLCO1A2 SLC22A8 GGT7 GGT6 SULT1A1 SULT1E1 GGT3P SULT1A4 SULT1A3 SULT2A1 SULT1C4 CES2 ADH1A ACSM2B MAPDA ALB ADK ABCC1 PNP ADA VAV3 ABCC4 GSTM1 TPMT ABCC5 NME2 GMPS NME1 VAV2 IMPDH1 GUK1 GSTA2 IMPDH2 GSTA1 HPRT1 SLC28A2 CES1 SLC29A1 NUDT15 UGT1A3 XDH SLC29A2 SLC28A3 SLC22A3 ABCB1 GGT1 GSTP1 GGT5 ABCC3 NT5C2 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling LEF1 CTNNB1 MYC TCF7 TCF7L2 TCF7L1 CCND1 RUNX3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD4 SMAD3 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 IRS1 PIK3CA PIK3R1 SRC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly LAMB3 ITGA6 LAMA3 DST COL17A1 LAMC2 PLEC CD151 ITGB4 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin SLC6A4 MAOA ALDH2 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle PRKAA2 SLC25A20 MID1IP1 PRKAG2 CPT1A PPARD CPT1B CPT2 PRKAB2 SLC22A5 RXRA THRSP NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis PFAS ATIC PPAT ADSL GMPS IMPDH1 CAD IMPDH2 UMPS GART PAICS DHODH ADSS1 ADSS2 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM1 MRM2 MRM3 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 PPP2CA PPP2CB UBA52 NCBP1 NCBP2 UBB UBC RPS27A CBL HNRNPM HNRNPF TIAL1 TIA1 RBFOX2 ESRP2 NRAS GAB1 FRS3 MAPK1 HRAS MAPK3 PLCG1 POLR2A FRS2 POLR2B POLR2C BRAF POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I PTBP1 POLR2J POLR2K PPP2R1A POLR2L SOS1 GTF2F1 GTF2F2 FGF1 FGFBP1 FGF2 FGFBP2 FGF3 FGFBP3 FGF4 FGF6 FGF7 FGF9 FGF20 HNRNPA1 HNRNPH1 FGF23 FGF22 FGF16 MKNK1 FGF18 SPRY2 PIK3CA PIK3R1 FGF10 PTPN11 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors S1PR2 S1PR5 S1PR4 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 S1PR1 LPAR1 LPAR2 LPAR3 LPAR5 S1PR3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR PIGS GPAA1 PIGU PIGK PIGT PLAUR PGAP1 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 SEL1L PSMA2 UBA52 DHH PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HHAT ADRM1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 IHH SYVN1 SHH ERLEC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 RIPK3 PPP2R5D MEF2C TRAF2 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 TP53 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling ATP5MF ATP5ME DMAC2L ATP5PF ATP5PD ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5MC2 ATP5PO ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP5MK ATP5MJ ATP5MG SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 CDK5 TIAM1 CDK5R1 NTRK2 RAC1 BDNF ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation RAP1A NTRK1 CRK KIDINS220 BRAF NGF YWHAB MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis MOCS2 MOCS3 GPHN MOCOS INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing CPSF4 PABPN1 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD MAT1A CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 BUB1B CDC20 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response PDE12 OASL OAS2 OAS1 OAS3 RNASEL RIGI ABCE1 FLNA VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways EZH2 MAGT1 RAC1 JAK1 H3C8 VAV1 H3C15 RICTOR PAK2 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 ATP6V1H H2BC1 TUSC3 NEK2 H2AC8 H2AC6 H2AC7 ZBP1 TBK1 TMEM258 IRF3 VCP OST4 OSTC STT3A STT3B PRR5 GSK3B H2BC26 H2BC21 MLST8 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 LCK H2BC11 RBBP4 FYN RBBP7 PTPN11 MTOR CD4 PTPN6 PDCD1 HDLBP AP2A1 CCNK CCNT2 AP2A2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB AP2M1 ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 ELOA2 SSRP1 AP2S1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 AP2B1 GJA1 P4HB HSPG2 SDC4 SDC2 SDC3 LIG4 XRCC4 SDC1 NUP205 ARID4A POM121 ARID4B FNTA NUP188 FNTB PSIP1 AAAS IL1R1 SAP30 POM121C BRMS1 NUP42 NUP62 IFNAR1 PHF21A TPR BANF1 CD79B NUP88 CD79A RAE1 SUDS3 KPNA1 RCOR1 IGHM NUP214 NDC1 BLNK HMG20B NUP210 JAK3 NUP155 GPC1 HMGA1 IFNGR1 NUP153 IFNGR2 SIGMAR1 NUP93 GPC3 NUP50 TYK2 IGHD NUP35 GPC2 NUP54 SAP30L SLC25A5 S1PR1 SLC25A4 SAP18 GPC5 CRBN SLC25A6 GPC4 STAT2 GPC6 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 AGRN CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 RPL4 PAPOLA SYMPK RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 TKFC RPL35 KPNA4 RPL38 KPNA5 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPS4Y2 RPS4Y1 RPL39L CPSF4 RPL41 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 CDC73 HSPA1A HLA-B SKIC8 RUNX1 CTR9 TRAF3 RTF1 CD14 IKBKE LEO1 PAF1 FASN RNASEK PROS1 CLDN1 HNRNPU MTA1 MRC1 EMC4 CD33 MTA3 HSPA5 CD300A TIMD4 MERTK EIF4A3 AXL TYRO3 MAPRE3 GAS6 LY6E CDC40 SRRM1 SRSF2 SRSF3 GSK3A SRSF4 PARP6 SRSF5 PARP4 SRSF6 GALNT1 SRSF7 PARP16 PARP9 SRSF9 PARP14 PARP8 PARP10 PRKG2 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 CHMP5 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 ANO10 HLA-A B2M AP1M2 AP1M1 TUFM IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 IGKV2D-30 NMT2 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 CSNK1A1 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CD209 UBE2N TAB3 TAB2 TAB1 ITGB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 RCC1 IGKC DOCK2 NMT1 IGLV3-21 CCR5 IGKV1-39 IGKV1-33 RANBP1 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 IGLC6 YWHAH YWHAZ PPP1CB HDAC1 PPP1CA CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI SRPK2 SRPK1 CX3CR1 RAB5B IMPDH1 RAB5C IGF1R NCL IMPDH2 RAB5A NRP1 HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 CPSF7 NCK1 VIM HNRNPC RBMX FURIN DPM1 DPM2 DPM3 RPTOR EIF4E EIF4G1 TMPRSS2 ACE2 HAVCR1 ELK1 ARF1 SEC23A SAR1B HSPA8 SCAP SEC24B SEC24A COMT SP1 SEC24D SEC24C PIK3R4 CASP1 TLR9 PIK3C3 PDCD6IP RIPK3 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 IL6R RIPK1 KEAP1 UBE2L6 HERC5 ITCH CHMP2B CHMP2A ATG7 TRIM4 F2 ATP1B3 ATP1B2 ATP1B1 CAMK2B CAMK2D CAMK2A ATP1A4 ATP1A3 ATP1A2 ATP1A1 CAMK2G CUL5 UBA7 UBA6 UBA5 UBR4 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 UBA3 UBA1 IFNB1 VHL ELAVL1 C4BPA C4BPB BCL2L1 CLU EEF1A1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 C4A C4B_2 H2BC18 BECN1 UVRAG MAP1LC3B ISCU HCK CD8B ELMO1 ACOT2 ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 BTK MGAT1 MGAT2 GOLGA7 PLCG2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 LARP1 EDEM2 GRPEL1 MOGS HYOU1 SYK ZDHHC11 MED19 MGAT4C MED18 ZDHHC9 PQBP1 MGAT4A MED11 MGAT4B MED29 MAN1B1 MED28 ST6GALNAC3 MED22 ST6GALNAC4 MED21 ATL2 SRRT VPS33A VPS33B ZCRB1 SNRNP200 PYCARD G3BP1 G3BP2 FUS NACA CYSLTR1 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA0 HNRNPA3 GPKOW CNBP CDC5L KDELR1 NLRP3 CCAR1 CD2BP2 PCBP1 PCBP2 RBM10 MED13L BST2 RETREG1 SUGP1 DHX15 DHX16 UFD1 ARIH1 SFTPD BCAP31 PEX19 NLRP12 HNRNPA2B1 IL17F IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG PPIB RTN3 DDX3X DDX46 DDX42 SFN RBM17 LIG1 SUN2 DYNLT1 BUD31 MMP9 RBM22 DDX23 RRBP1 SMNDC1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM HNRNPK NPLOC4 HNRNPF HNRNPD CLINT1 MED16 SF3B4 MED15 SF3B5 MED17 SF3B2 SF3B3 MED12 SF3B6 MED14 SF3B1 MED13 SF3A3 SF3A1 SF3A2 MED10 XAB2 PHF5A HSPA1B CLEC4M AUP1 IPO7 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 MED27 P4HA2 MED26 P4HA3 RCAN3 EIF4G3 MED23 EIF4G2 MED25 EIF4E3 MED24 PTBP1 MED20 PLRG1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 VPS41 EGFR NPIPB3 VPS45 PPIL3 PPIL4 PPIL6 SRRM2 AQR HLA-H HLA-C HLA-F CRNKL1 HLA-G MBD3 HLA-E NMI PRPF19 CHMP1A TOMM70 IL17RC IL17RA TLR1 GATAD2B HNRNPH1 GATAD2A HNRNPH2 TLR6 TLR2 SPCS3 SPCS2 SPCS1 CWC25 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 PSMD8 OAS2 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RIPK2 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NFKBIB MED30 NOD1 NOD2 MED31 IRAK2 UBE2I NR3C1 SUMO1 ITGA4 CCNC TRIM28 SH3KBP1 CTNNB1 TUBB YWHAB SNW1 CTSL EXOC1 SOS1 NPM1 GBF1 HDAC3 LY96 XPO1 EP300 TBL1X IRAK1 MED1 CREBBP APOA1 NCOR1 TBL1XR1 CHD4 CHD3 TLR4 NFE2L2 YWHAQ PPIA FKBP1A MTA2 YWHAE COG1 REST MED8 MED4 MED6 MED7 RBX1 NEDD4L NCOR2 TAL1 GPS2 XRN1 KDM1A FKBP4 DDX5 PTGES3 CUL3 NRBP1 RB1 DAXX NUP107 PPP1CC CDK8 DYNC1LI1 DYNC1LI2 NUP160 NUP85 RPS27 SEC13 NUP133 HDAC2 DYNLL1 RANGAP1 DYNLL2 DYNC1I2 PML NUP43 DYNC1I1 RANBP2 DYNC1H1 TAOK1 NUP37 FEN1 PRMT1 EIF4A2 EIF4A1 TJP1 CCNH RNMT POLR2A POLR2B POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 YBX1 CDK7 ERCC3 H2AC17 ERCC2 H2AC12 MNAT1 H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 AKT2 TLR8 TLR7 AKT3 TLR3 AKT1 CSNK2A1 CSNK2A2 CSNK2B MASP1 MBL2 RPN2 MAPKAP1 C1QA RPN1 C1S PIK3R1 JAK2 CGAS LYN IRF7 H4C9 DHX9 XRCC6 XRCC5 H2AC20 STING1 CD28 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases CALM1 ATP10D ATP10B ATP10A ATP2C2 ATP2C1 ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 PDZD11 ATP2A3 ATP2A2 ATP2A1 SLN ATP1B3 ATP1B2 ATP1B1 ATP8A2 ATP8A1 CAMK2B ATP12A CAMK2D CAMK2A ATP1A4 ATP1A3 ATP1A2 ATP11C ATP11B ATP1A1 ATP11A SRI PLN CAMK2G ATP2B4 ATP2B3 ATP2B2 ATP2B1 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B ATP4A CUTC ATP7B ATP7A PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins PRKCQ PTK2 PRKCD CASP6 STK24 STK26 LMNB1 ACIN1 CASP7 DBNL GAS2 MAPT ADD1 PLEC ROCK1 CDH1 CASP8 CTNNB1 SPTAN1 BMX DSP APC TJP1 OCLN CASP3 DSG1 SATB1 PKP1 DSG2 VIM DSG3 TJP2 BIRC2 BCAP31 FNTA CLSPN GSN DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism MCCC2 MCCC1 PPM1K AUH IVD HIBCH OPLAH CYP24A1 BTD HLCS CBLIF CD320 CYP19A1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC BCKDK BCKDHA DBT BCKDHB DLD GSS CYP11A1 CYP2R1 SI CYP17A1 LCT CUBN AMN HGSNAT TBXAS1 NOTCH1 ECHS1 POMC IDH1 MGAT2 PMM2 MPI ST3GAL3 MOGS TPMT OMD ABCA3 DAG1 TALDO1 HSPG2 MAN1B1 PPP1R3C NHLRC1 DPAGT1 ALG8 SDC4 ALG9 SDC2 ALG6 HPRT1 SDC3 ALG2 ALG3 GNS ALG12 ALG1 MPDU1 RFT1 CHST14 GGT1 EXT1 EXT2 CYP11B2 B4GAT1 CYP21A2 SDC1 CYP2U1 GBE1 CYP1B1 KHK GYS2 GYS1 CHST6 GAA SFTPD ALDOB DHDDS DPM1 DPM2 DPM3 CHST3 GNE PAPSS2 GPC1 GPC3 IDUA GPC2 NEU1 HEXB NCAN GPC5 HEXA GPC4 BGN GPC6 DCN CTSA NUS1 BCAN ALG11 FMOD VCAN AGRN GLB1 HYAL1 NAGLU SRD5A3 GFPT1 GYG2 DOLK CSPG5 IDS GYG1 ACY1 NOTCH2 CSPG4 SLC35D1 EPM2A GUSB ARSB KERA NOTCH3 NOTCH4 UGT1A1 SLC26A2 SLC34A2 UGT1A4 POMT2 SEMA5A GALNT12 SPON2 SEMA5B ACACA SPON1 B3GALT6 THSD7B POMT1 G6PC3 ADAMTS4 ADAMTSL1 LFNG SFTPC OGN ADAMTS5 MTRR C1GALT1C1 AHCY ADAMTS2 MC2R ADAMTS3 ADAMTSL5 GALK1 MTR ADAMTSL4 MAT1A ABCD4 ADAMTS1 ADAMTSL3 B4GALT1 SFTPA2 ADAMTSL2 MUC12 MUC13 THSD7A SGSH LMBRD1 MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 SLC37A4 FMO3 PGM1 POMGNT1 MUC3A MUC5AC MUC3B DCXR ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 B4GALT7 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 GALT MUC7 MUC4 MUC6 PRELP GALNT3 MUC16 ACAN CYP7B1 MUC17 C1GALT1 CHSY1 CYP27A1 MUC19 TCN2 SSPOP MUC5B MUC20 MUC21 B3GAT3 LUM GALNS RPIA GALE UBA52 PC GALM ALG14 ALG13 ACAT1 UBB UBC RPS27A APRT CYP4F22 PNP ADA SFTA3 G6PC1 SFTPB SFTPA1 PAH CYP26B1 FDX1 CYP26C1 FDXR FDX2 MAOA THBS1 CYP27B1 CYP11B1 GCLC PCCA MMAA GCLM PCCB MMUT CSF2RB CSF2RA MMAB MMACHC MMADHC INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling IL11 CNTFR CNTF OSMR IL31RA IL31 OSM SOCS3 CTF1 JAK2 CLCF1 IL11RA LIF IL6 STAT1 TYK2 LIFR JAK1 STAT3 CRLF1 IL6R PTPN11 IL6ST CBL NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 SH2B3 SOCS2 ABL2 FLT3LG SOCS6 UBA52 SLA2 SLA UBB CSK PTPRJ FLT3 UBC RPS27A CBL DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN FGF10 EGF FGF2 FGF4 LAMA5 FGF7 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) CYP8B1 PTGS2 PTGES2 PTGES AKR1C3 CBR1 HPGDS PRXL2B PTGDS PTGES3 PTGR2 HPGD PTGS1 PTGIS TBXAS1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1C1 MUC1 MUC2 MUC12 MUC7 MUC13 MUC4 MUC6 MUC15 MUC16 MUC17 C1GALT1 MUC19 MUC5B MUCL1 MUC20 MUC21 MUC3A MUC5AC MUC3B RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria GSDMD CYCS BAX GSDME DIABLO BAK1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism FADS1 ACSL1 ELOVL1 ELOVL5 ELOVL2 ELOVL3 ABCD1 FADS2 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM MMUT MMAA REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion INS PRKACG PRKACB KCNB1 SLC2A2 KCNS3 MARCKS SYT5 GLP1R SNAP25 VAMP2 STX1A GNGT1 ACSL4 CHRM3 ACSL3 FFAR1 RAP1A GNGT2 RAPGEF3 RAPGEF4 CACNA1D AHCYL1 PRKAR1B PRKAR2B CD36 PRKACA STXBP1 CACNA2D2 PRKCA PLCB3 PLCB1 PLCB2 SLC2A1 ADCY8 GNAQ ADRA2C GNG10 ADCY6 GNG3 PRKAR2A ADRA2A ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 CACNA1C GNG5 ITPR3 GNG4 GNG7 PRKAR1A GNG8 AKAP5 KCNJ11 KCNG2 ABCC8 CACNB2 CACNB3 IQGAP1 CACNA1A CACNA1E GNA14 GNA15 GNA11 GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 KCNC2 GNB3 GNB5 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis COQ6 COQ5 COQ4 HPDL COQ3 COQ2 COQ8B COQ8A PDSS2 PDSS1 STARD7 COQ9 COQ7 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism CTRB1 PRSS3 MTRR MTR LDLRAP1 CBLIF ABCD4 CUBN MMAA TCN1 AMN CD320 MMUT LMBRD1 ABCC1 LRP2 TCN2 MMAB PRSS1 MMACHC MMADHC CTRB2 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome ABCC9 KCNJ11 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG PLD3 PLD2 CDS2 PLD1 PLD4 PLD6 PGS1 PTPMT1 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 PRKCG KPNA2 ADCY9 PRKAR1B CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer GSK3A CHUK NR4A1 FOXO3 TSC2 MDM2 AKT1S1 PRR5 AKT2 GSK3B AKT3 BAD CASP9 AKT1 MLST8 PDPK1 MAPKAP1 FOXO6 CDKN1A FOXO4 RICTOR CDKN1B FOXO1 RPS6KB2 MTOR NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly H2AX MTA2 H3-3B H3C8 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 CHD5 H2BC3 IKZF1 UBE2I IKZF2 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 SUMO1 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 G6PC1 H2AC19 H2AC14 H2BC12L NR2C2 MBD3 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 FBP1 H2BC15 HDAC2 H2BC11 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance RAC1 PAK1 MAPK7 PAK3 PAK2 GAB1 GRIN2B TIAM1 PLCG1 ADAM10 GSK3B PIK3CD CLTCL1 PIK3CB PIP5K1C ARHGEF11 ARHGEF12 RHOB SHANK3 PIK3CA ARHGEF28 GIT1 COL4A2 COL4A1 COL6A2 COL4A4 CDC42 COL6A1 COL4A3 FYN COL9A1 COL6A3 PTPN11 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 AP2A1 RHOC AP2A2 ARHGEF7 PRKACG NGEF PRKACB ELOB AP2M1 ELOC NCBP1 NCBP2 PLXNB1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B AP2S1 AP2B1 ACTB ARPC1B ARPC1A CFL1 WASL SDC2 GRIN1 MYH9 ARPC4 ARPC5 ARPC2 ARPC3 GRB7 ACTR3 ACTR2 RND1 PLXNA1 PLXND1 MYO10 MYL9 GPC1 MMP9 AGRN RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPS6KA6 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 EGFR RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 PSMD14 ARHGAP39 PSMD13 SEMA4D SLIT2 SRGAP3 LIMK2 PSMA7 SRGAP2 LIMK1 SRGAP1 RRAS ROBO1 MYH14 PSMB6 MYH10 PSMB7 PSMB4 PSMB5 DPYSL4 UBB DPYSL5 PSMB2 DPYSL3 PSMB3 UNC5C UBC UNC5D PSMB1 AGAP2 RPS27A DSCAML1 ADRM1 PLXNC1 SEMA6A SEM1 SEMA6D PSMC5 PSMC6 SEMA7A PSMC3 RAP1GAP PSMC4 PLXNA2 PSMC1 PSMC2 PLXNA3 PTPRC PTPRA PLXNB3 TREM2 SEMA3A NTN4 SEMA3E EIF4A3 CASC3 ABLIM1 ABLIM2 ABLIM3 MAGOH SEMA4A ARTN GFRA3 RGMB GFRA2 RGMA GFRA4 CD72 NRTN DSCAM DOK1 DOK2 TYROBP DOK4 DOK5 DOK6 CACNA1S RBM8A PRNP PSPN HJV PRKCA CRMP1 PDLIM7 UPF3B MAGOHB RNPS1 PITPNA ITGA5 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 LAMA1 NEO1 LAMB1 LAMC1 SH3KBP1 SRC MET SH3GL2 SHC3 SHC1 NRAS FARP2 MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 FRS2 PRKCQ SOS1 RHOA GFRA1 RPS6KA5 GDNF ITGB1 TRIO ITSN1 ARHGAP35 LDB1 PPP3CB DOCK1 EPHA1 EPHA2 KALRN UNC5A PAK4 CDK5 RPS6KA1 UNC5B CDK5R1 RBX1 RET VAV3 ITGAV PTK2 DAG1 HOXA2 ISL1 PFN1 VAV2 PFN2 GSPT2 GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 AKAP5 ZSWIM8 PAK6 PAK5 CAP2 MYO9B ACTG1 MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 EPHB6 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 RPS6KA4 EPHA3 ALCAM ITGA2B EPHA10 SCN11A EFNA5 DPYSL2 EFNA4 SCN9A EFNB2 NRCAM EFNB1 EPHB2 EFNB3 SCN1B EFNA1 RASA1 SCN1A EFNA3 ANK2 EFNA2 ANK3 ANK1 SHTN1 SCN10A SCN8A KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 NCAN ST8SIA4 SPTA1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN L1CAM ST8SIA2 KIF4B KIF4A ITGA10 CNTN1 EIF4G1 CNTN2 CD24 SCN2A CACNA1H MYL12A SCN2B NRP2 CNTNAP1 MYL12B CHL1 CACNA1G CACNA1I SCN5A SPTAN1 LYPLA2 SPTB MYH11 DNM1 DNM3 GAP43 DCX ABL1 NUMB SCN4A SCN4B ITGA9 SCN7A NCAM1 RANBP9 CLTB NFASC MYL6 PLXNA4 SEMA5A HSPA8 DNM2 DLG1 DLG3 CACNA1C DLG4 IRS2 RPS27 CACNB1 CACNB2 CACNB3 GAB2 CACNB4 ITGA2 ITGA1 SDCBP CLASP1 CLASP2 RELN DAB1 VLDLR SIAH2 SIAH1 FES CACNA1D PRKACA ERBB2 CSNK2A1 CSNK2A2 CSNK2B ITGB3 PIK3R3 PIK3R2 PIK3R1 GRB10 LYN RPS6KA3 RPS6KA2 YES1 TLN1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNGT1 PLCB3 PLCB1 PLCB2 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GRIK3 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSH ARSI ARSF ARSB ARSG STS ARSD ARSA SUMF2 SUMF1 ARSL ARSJ ARSK DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A VWF TPST2 TPST1 F9 F2 F8 F10 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism KYNU SLC36A4 KYAT3 HAAO AADAT SLC7A5 KYAT1 KMO TDO2 SLC3A2 IDO2 IDO1 ACMSD AFMID REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation KAT2B SIRT1 EP300 FOXO4 FOXO1 TXNIP TXN CREBBP FOXO3 SIRT3 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling TGFBR3 GIPC1 FGF2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD3 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC34A1 SLC20A2 SLC20A1 SLC17A1 SLC34A3 SLC34A2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 VWF GP1BA GP9 GP1BB DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS CSPG5 CSPG4 NCAN BGN CHSY1 DCN BCAN VCAN DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER GTF2H1 ERCC4 GTF2H2 ERCC1 ERCC5 GTF2H3 UBA52 GTF2H4 GTF2H5 ERCC3 ERCC2 POLK POLE RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 RPS27A RBX1 PCNA POLD3 POLD4 POLD1 POLD2 PARP1 PARP2 CHD1L CUL4A RPA1 DDB1 RPA2 POLE4 CUL4B XPA RPA3 DDB2 POLE2 POLE3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling INS PTPRF TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B IDE ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INSR ATP6V0A2 ATP6V1H CTSD ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 PTPN1 ATP6V1F ATP6V1C2 ATP6V0A1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency GCN1 EIF2AK4 IMPACT CEBPB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 CEBPG RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 ASNS RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 ATF2 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A ATF4 TRIB3 ATF3 DDIT3 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling SQSTM1 MAP2K1 MAP3K8 UBE2V1 NFKB2 HMGB1 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TRAF2 IL1A IL1B PELI1 PSMD8 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 APP IL1RN PSMA1 PSMA2 UBA52 TOLLIP PSMD12 IL1R2 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 MYD88 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 NKIRAS1 PSMB3 UBC NKIRAS2 IKBIP PSMB1 RPS27A ADRM1 NFKB1 SEM1 IRAK4 NFKBIA RBX1 PSMC5 PSMC6 PSMC3 PSMC4 LRRC14 PSMC1 USP14 PSMC2 NLRX1 MAP3K3 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 IRAK3 TP53 TIFA ALPK1 MAP2K4 MAP2K6 IL1R1 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 GAB1 MET HGF PTPN11 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death CASP8 TICAM1 TLR3 RIPK3 RIPK1 FADD LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se NNMT CTH GNMT AHCY CBS SCLY HNMT MAT1A DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation PRKCB STX4 PRKCG PRKCA STXBP3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction HSD17B6 GUCY2F HSD17B1 NMT1 LRP1 CALM1 RDH12 LRP8 OPN1LW AWAT2 GPC1 GPC3 APOA2 GPC2 BCO2 APOA4 SLC24A1 RHO GPC5 BCO1 SAG GPC4 CNGA1 RCVRN GNAT1 GPC6 CNGB1 SDR9C7 AGRN METAP1 METAP2 LPL CAMKMT LDLR GPIHBP1 RGS9BP MYO7A GNGT1 OPN1MW APOE APOC3 APOC2 TTR ABCA4 GRK1 GUCA1B GUCA1A GUCA1C GRK7 PLB1 PRKCQ APOM NMT2 AKR1C3 PRKCA DHRS3 HSPG2 PDE6B SDC4 PDE6A DHRS9 SDC2 RDH11 PDE6G SDC3 LRP10 RDH10 RDH16 RPE65 RDH5 PPEF1 AKR1B10 LRP12 OPN1SW STRA6 APOB SDC1 RDH8 CYP4V2 LRAT RLBP1 APOA1 AKR1C1 AKR1C4 RBP4 RBP2 LRP2 RBP3 GNB1 CLPS RBP1 FNTA RETSAT FNTB GUCY2D PNLIP AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS TGFA SOS1 EGF EREG BTC AREG EPGN HBEGF EGFR NRAS BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SLC35C1 ALG5 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL FUOM ALG10B NEU2 NEU3 ALG14 NEU4 ALG13 DHRSX GMDS SLC17A5 AMDHD2 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA NUS1 ALG11 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 GLB1 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ST6GALNAC2 MVD ST3GAL4 GMPPB PMM1 GMPPA ST3GAL1 PMM2 MPI ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 ST6GALNAC4 DPAGT1 ALG8 ALG9 HK1 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 ST3GAL6 ALG10 ST6GALNAC6 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU UBE2D1 RPL26L1 UBB UBC RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 UBE2D2 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 ASCC2 RPS10 ASCC3 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A ZNF598 RPS3A UBE2D3 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha SLC27A1 CCNC PPARGC1B CYP1A1 AHRR MED9 CDK19 ACADM MED16 MED15 MED17 MED12 MED14 MED13 MED10 UGT1A9 HMGCS1 SREBF2 MTF1 MED27 MED26 ESRRA G0S2 FHL2 MED23 MED25 FADS1 MED24 TNFRSF21 MED20 FDFT1 CDK8 ABCB4 RXRB NFYA NFYB NFYC ANKRD1 SP1 GRHL1 HDAC3 SMARCD3 ACSL1 CHD9 PEX11A CPT2 NPAS2 SIN3A HELZ2 TGS1 EP300 TBL1X PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 NR1H4 TBL1XR1 PLIN2 CARM1 CYP7A1 BMAL1 CLOCK TXNRD1 ALAS1 TIAM2 SULT2A1 HMGCS2 APOA2 APOA5 MED8 ANGPTL4 MED4 MED6 MED7 ARNT2 ABCA1 RGL1 MED30 NR1H3 MED31 FABP1 NR1H2 RORA CPT1A RXRA PPARG AGT PPARA CD36 MED19 MED18 THRAP3 MED11 MED29 FAM120B MED28 NCOR2 MED22 MED21 GPS2 TRIB3 ARNT CYP4A11 MED13L ME1 NCOA3 GLIPR1 NRF1 AHR FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 FBXL7 PSMC4 PSMC1 PSMC2 FBXL18 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex BCL7A PBRM1 BCL7C BCL7B SMARCB1 SMARCD1 SMARCD2 PHF10 SMARCA2 ACTB SMARCA4 SMARCC1 SMARCD3 SMARCC2 ACTL6A ARID2 SMARCE1 BRD7 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia F9 F8 F10 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEK2 BUB1B CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC CD320 TCN2 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense CASP4 CALM1 GBP1 GBP6 UBA52 UBE2D2 CALM3 CALM2 GBP2 UBB GBP4 UBC RPS27A DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response ATM H2AX HERC2 UBA52 CHEK2 UBB UBC RPS27A MAPK8 H2BC9 H3-4 PIAS4 H2BC8 H2BC5 ABL1 H2BC3 UBE2I H2BC1 BRCC3 SUMO1 KPNA2 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 NBN H2BC12L SMARCA5 PPP5C H2BC26 UBE2V2 BAP1 UBXN1 H2BC21 BAZ1B APBB1 UBE2N KDM4A MDC1 H2BC17 EYA1 EYA2 H2BC12 H2BC13 EYA3 H2BC14 EYA4 H2BC15 H2BC11 BARD1 H4C9 KDM4B RAD50 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis ACD H2AX ATR SUN2 LMNB1 SYCP2 SYCP1 SYNE2 SYNE1 SUN1 TEX12 TERF1 TERF2 SMC1B H2AJ SYCE3 SYCE2 POT1 SYCE1 TERF2IP REC8 STAG3 SYCP3 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 UBE2I H2BC1 H2AB1 SMC3 H2AC8 H2AC6 H2AC7 BRCA1 H2AC19 H2AC14 H2BC12L RAD21 H2BC26 STAG1 H2BC21 STAG2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 FKBP6 SMC1A H2BC11 H4C9 TINF2 HSPA2 H2AZ2 H2AC20 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization CADM1 PVR NECTIN4 NECTIN3 NECTIN2 NECTIN1 CADM3 CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis GATA4 KAT5 ISL1 KAT2A EOMES GATA6 TBXT WDR5 CTNNB1 NKX2-5 HAND2 FOXO4 SRF HEY1 MEF2C MESP1 TBX20 HEY2 SMYD1 LEF1 TBX1 MYOCD HAND1 LDB1 SMAD1 SMAD4 TBX5 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition MCM6 MCM2 CCNB1 CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 RB1 CDKN1A CDKN1B CCND1 E2F1 SKP2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 CDC6 PPP2R1B PPP2R1A PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 RRM2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 MCM10 MAX PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PTK6 PSMC1 RPA4 LIN54 PSMC2 CKS1B LIN52 LIN37 HDAC1 LIN9 CABLES1 WEE1 CDC7 CCNH CDK7 MNAT1 POLE RBL2 RBL1 AKT2 MYC AKT3 AKT1 FBXO5 PCNA DHFR E2F4 TK1 TYMS E2F5 PPP2R3B E2F6 RPA1 RPA2 CDC45 POLE4 MCM7 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance AMN HDLBP APOA1 CUBN TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes AURKA SFN BAX ZNF385A CDC25C PCBP4 CCNB1 CDK1 GADD45A CCNA2 CCNA1 PRMT1 CPAP CDKN1A CDKN1B PLK3 E2F1 TFDP1 CCNE2 CNOT6L TFDP2 CCNE1 CDK2 BTG2 CNOT4 CNOT6 CNOT7 TNKS1BP1 RGCC CNOT1 TP53 CNOT2 CNOT3 NPM1 CNOT8 PLAGL1 CNOT9 RBL2 RBL1 PLK2 EP300 ARID3A PCNA CNOT10 E2F4 CNOT11 CARM1 E2F7 E2F8 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling TBK1 TNF TNFRSF1A RBCK1 USP2 IKBKE OPTN TRADD CASP8 TRAF2 RNF31 MIB2 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 BIRC2 USP4 BIRC3 XIAP CYLD OTUD1 RIPK1 FADD RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions MT1E CSRP1 SNCB MT2A MT1A MTF1 MT1M MT1F MT1G MT1X MT1H MT4 MT1B MT3 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TNFSF12 LTA TRAF2 LTB LTBR TNFRSF11A TNFSF11 MAP3K14 TRAF3 BIRC2 BIRC3 TNFRSF13C TNFRSF12A CD40LG TNFSF13B ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin INHBB FST INHBA FSTL3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion PRKAR2B PRKACA PRKACG PRKACB KCNB1 ADCY8 GNG10 ADCY6 GNG3 PRKAR2A ITPR1 ADCY5 GNG2 KCNS3 ITPR2 GNG5 ITPR3 GNG4 GNG7 GNG8 PRKAR1A AKAP5 KCNG2 GLP1R IQGAP1 GNGT1 RAP1A GNGT2 GCG GNG12 GNG11 GNG13 GNB2 RAPGEF3 RAPGEF4 GNB1 GNAS GNB4 KCNC2 GNB3 GNB5 PRKAR1B PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination UBA1 UBE2K UBE2C UBA52 UBE2E1 UBE2D1 UBE2Q2 CDC73 RNF152 SHPRH HLA-B RRAGA BCL10 UBE2S USP7 PEX2 HLA-A RNF40 UBE2R2 RNF144A SKIC8 SELENOS WAC UBE2J2 CTR9 RTF1 UBB TMEM129 HLTF UBC LEO1 PEX10 RPS27A PEX12 PEX13 DERL1 PEX14 PAF1 RNF181 USP5 H2BC9 UBE2D2 H2BC8 H2BC5 H2BC3 H2BC1 UBE2G1 UBE2B UBE2G2 RAD18 CDC34 VCP UBE2Z UBE2E3 OTULIN UBE2V2 USP9X UBE2L3 UBA6 UBE2N UCHL3 H2BC17 H2BC12 H2BC13 PCNA H2BC14 RNF20 H2BC15 H2BC11 UBE2H UBE2D3 PRKDC UBE2A UBE2T UBE2W SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea KCNMB1 KCNMA1 EZR SPTBN1 RDX MSN CLIC5 RIPOR2 SNAP25 CIB2 PJVK ESPN EPS8 SPTAN1 PLS1 TPRN TMC1 VAMP2 MYO7A STX1A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 PCLO USH1C CAPZB ESPNL BSN EPB41L3 SYP CABP2 CDH23 CACNA1D XIRP2 CABP1 EPS8L2 LRRC52 OTOF GRXCR1 CASK SLC17A8 GRXCR2 CAPZA1 WHRN CAPZA2 LHFPL5 TMIE USH1G STRC EPB41L1 MYO15A CACNA2D2 SYN1 RAB3A TWF1 MYH9 CACNB2 ATP2B1 DNAJC5 MYO1C ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation FBLN2 FBLN5 FURIN TGFB2 MFAP5 ITGAV MFAP4 FBN1 VTN MFAP3 MFAP2 LTBP4 LTBP2 LTBP3 LOX LOXL3 LOXL4 LTBP1 LOXL1 ITGB8 TGFB1 LOXL2 ITGB6 TGFB3 ITGB5 BMP4 ITGA8 GDF5 ELN ITGB1 ITGB3 ITGA5 BMP7 BMP2 EFEMP2 EFEMP1 BMP10 FBN2 FBN3 FBLN1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling CHUK PPP2CA PPP2CB FBXW11 JUN UBA52 CUL1 RIPK2 RPS6KA1 FOS ATF1 UBB UBC IL25 MEF2A RPS27A DUSP4 DUSP3 NFKB1 VRK3 MAPK9 DUSP6 MAPK8 IL17RE DUSP7 MAPK7 IL17RB ELK1 MAPK10 NOD1 IL17C NOD2 IRAK2 MAPK1 MAPK3 TNIP2 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 IL17RC RPS6KA5 IL17RA UBE2N TAB3 TAB2 TAB1 IRAK1 PPP2R5D MEF2C RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG IL17F BTRC MAP2K7 IL17A MAP3K7 MAP2K6 SKP1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence ATM ACD H2AX HMGA2 H1-1 H1-0 H1-3 H1-2 HMGA1 H1-5 H1-4 LMNB1 CABIN1 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP HIRA UBN1 RB1 CDKN1A CDKN1B H2BC9 H3-4 H2BC8 H2BC5 H2BC3 H2BC1 CCNE2 CCNE1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 MRE11 KAT5 TP53 NBN H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H4C9 TINF2 ASF1A RAD50 EP400 H2AZ2 H2AC20 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking WNT8A WNT8B WNT6 WNT11 WLS VPS29 WNT1 VPS35 WNT2 WNT3 TMED5 WNT4 WNT10B VPS26A SNX3 WNT10A WNT5B WNT2B WNT3A PORCN WNT7B WNT7A WNT5A WNT9B WNT9A WNT16 RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling DOK1 DOK2 DOK4 DOK5 SOS1 PRKACA DOK6 PRKACG PSPN PRKACB PRKCA PDLIM7 PIK3CD IRS2 PIK3CB GFRA1 GDNF MAPK7 RAP1GAP GAB2 SHANK3 PIK3R3 PIK3R2 PIK3R1 PIK3CA SHC3 SHC1 GRB7 GRB10 GAB1 ARTN PLCG1 GFRA3 GFRA2 FRS2 GFRA4 RET PTPN11 NRTN BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) ALOX5 ALOX12 HPGD PTGR1 ALOX5AP LTC4S PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling RAC1 VAV1 SRC PIP5K1A PIP5K1B TGFA MET EREG BTC EPGN HBEGF NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 CD86 EGF CD80 FRS2 FLT3 AREG PPP2R1B PPP2R1A CD19 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF IRS2 PIK3CD FGF1 FGF2 PIK3CB FGF3 PIK3CG NRG1 FGF4 FGF6 PIP5K1C FGF7 FGF9 FGF20 FGF23 PPP2R5E FGF22 GAB2 IRAK1 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A PIK3CA FGF10 PPP2R5D PPP2R5C LCK FYN TRAF6 RHOG PTPN11 PPP2CA PPP2CB INS PIP4K2A MYD88 PIP4K2B PDGFRA PDGFRB TRAT1 PDGFB IRAK4 NTRK3 PIK3AP1 IER3 FLT3LG KIT IL33 RAC2 IL1RL1 ESR1 ESR2 AKT1 ERBB2 STRN PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR CD28 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes TMEM219 CHM ZNF420 TNFRSF10B ATM TNFRSF10A TP53I3 TNFRSF10C AIFM2 FAS PERP BNIP3L TNFRSF10D BCL6 TP53AIP1 BAX TP53 CASP6 PRELID3A CASP2 PPP1R13B IGFBP3 TP53BP2 BID APAF1 NDRG1 RABGGTB RABGGTA CASP1 BBC3 TP63 PRELID1 STEAP3 CREBBP CASP10 TP53INP1 NLRC4 CRADD BIRC5 TP73 TRIAP1 PMAIP1 PIDD1 BCL2L14 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF9 FGF20 FGF23 FGF22 PIK3R1 PIK3CA FGF10 GAB1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 DISEASE%REACTOME%R-HSA-1643685.19 Disease DKK1 DKK2 TFG EZH2 DKK4 H2AX ASH2L CD3G MAGT1 F5 F8 RAC1 JAK1 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 LRP6 VAV1 H2AJ SEC31A DERL3 DERL1 DERL2 H3C15 OS9 RICTOR PAK2 BRD4 KLC1 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 CD86 TUSC3 CD80 H2AB1 NEK2 CYP19A1 H2AC8 H2AC6 H2AC7 TMEM258 VCP SEL1L OST4 NFKB2 OSTC STT3A STT3B RNF185 PRR5 GSK3B PIK3CD DPY30 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 LCK H2BC11 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN CSK RBBP7 TCF7L2 H2AZ2 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 ABCD1 TAF15 TAF12 ETV6 TAF13 FIP1L1 TAF10 TAF11 BIN2 ELOA2 KDR SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GJA1 ACTB TP53 LIG4 XRCC4 ATIC NUP205 ARID4A POM121 ARID4B FNTA NUP188 FNTB PSIP1 IL1R1 AAAS POM121C SAP30 BRMS1 NUP42 IFNAR1 NUP62 TPR PHF21A CD79B BANF1 NUP88 CD79A RAE1 SUDS3 KPNA1 RCOR1 IGHM NUP214 BLNK NDC1 NUP210 HMG20B JAK3 NUP155 HMGA1 IFNGR1 NUP153 IFNGR2 NUP93 SIGMAR1 TYK2 NUP50 IGHD NUP35 SAP30L NUP54 SLC25A5 S1PR1 SLC25A4 SAP18 CRBN SLC25A6 STAT2 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 PAPOLA RPL4 SYMPK RPL5 SLC35D1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 UGT1A1 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 UGT1A4 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 RPL35 KPNA4 RPL38 KPNA5 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 SFTPC RPS8 RPL23 RPS5 RPL22 RPS6 FGFR1 RPSA RPL9P9 SLC12A3 RPL24 SFTPA2 RPL27 RPL26 SLC12A1 RPL29 SLC12A6 RPL28 KPNB1 RPS4Y2 RPS4Y1 RPL39L CPSF4 RPL41 TGFB1 MLKL BAD EIF2AK2 CASP9 ISG15 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 CDC73 HSPA1A ALG14 ALG13 HLA-B SKIC8 RUNX1 CTR9 RTF1 LEO1 PAF1 FASN RNASEK PROS1 RPS6KB2 CLDN1 MRC1 EMC4 CD33 HSPA5 CD300A TIMD4 MERTK EIF4A3 MRAS AXL TYRO3 SHOC2 MAPRE3 GAS6 LY6E CDC40 SRRM1 CYP4F22 SRSF2 SRSF3 SRSF4 SRSF5 F11 SRSF6 SRSF7 SRSF9 SFTPB SRSF1 U2AF1 U2AF1L4 IRF4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 FN1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A ANO10 B2M AP1M2 AP1M1 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 V1-11 IGKV2D-30 V1-16 NMT2 V1-13 IGHV4-59 NRG2 IGHV1-69 NRG3 NRG4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 BCL2A1 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 CFTR IGKV3D-20 V5-6 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC RCC1 NMT1 IGLV3-21 IGKV1-39 CCR5 IGKV1-33 RANBP1 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YWHAH YWHAZ KIT RAC2 HDAC1 S100A9 S100A8 ECHS1 MARK3 POMC CAV1 PROC IFNA5 IFNA4 IFNA7 IFNA6 SLC5A5 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 VAV3 IFNA17 SIKE1 TPMT MAVS IFNA10 RIGI SRPK2 SRPK1 VAV2 CX3CR1 RAB5B IMPDH1 RAB5C IGF1R NCL IMPDH2 RAB5A HPRT1 SLC4A1 HSP90AB1 ROCK1 RHAG ROCK2 ACTG1 CPSF7 CDC37 VIM HNRNPC RBMX FURIN TGFBR1 TGFBR2 RPTOR TSC2 AKT1S1 PGK1 EIF4E EIF4G1 ACY1 STX1B SNAP25 SYT2 SV2C SYT1 SV2B SV2A VAMP1 VAMP2 STX1A APC SLC34A3 SLC34A2 TPM4 SLC34A1 TPM3 SEC23A PTPN12 POMT2 SAR1B SEMA5A GALNT12 SPON2 ACACA SEMA5B SPON1 THSD7B SCAP POMT1 ADAMTS4 ADAMTSL1 LFNG ADAMTS5 SEC24B C1GALT1C1 SEC24A ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 SP1 MUC12 MUC13 THSD7A SEC24D MUC15 SEC24C ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 POMGNT1 MUC3A MUC5AC MUC3B TRADD ADAMTS20 HMGB1 B3GLCT CFP CASP8 THBS2 ADAMTS12 CASP4 THSD1 THSD4 ADAMTS10 CASP1 ADAMTS16 ADAMTS15 MUC1 PDCD6IP ADAMTS14 RIPK3 ADAMTS13 IL18 MUC2 TRAF2 ADAMTS19 IL1A ADAMTS18 IL1B ADAMTS17 MUC7 CHMP4C MUC4 CHMP4B MUC6 GALNT3 CHMP3 MUC16 CHMP4A MUC17 CHMP6 C1GALT1 CHMP7 MUC19 SSPOP MUC5B MUC20 MUC21 RIPK1 FADD GSDMD GZMB ITCH CHMP2B CHMP2A GSDME SLC22A5 WDR48 F2 AHCYL1 SFTA3 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 SFTPA1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ATP1A3 ITPR2 ATP1A2 ITPR3 ATP1A1 CAMK2G KCNJ11 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 PCCA MMAA PCCB MMUT MAP2K4 ZAP70 TXN MMAB MMACHC MAP2K7 MMADHC MCCC2 MCCC1 PPM1K AUH IVD HIBCH AMER1 IL6 MDM2 TPST2 TPST1 F9 CYP24A1 CEBPB MAPK9 BTD MAPK8 HLCS CDKN2A IFNB1 CBLIF NTRK2 F10 BDNF GAB1 CD320 GGCX FRS3 NTF4 NTF3 PLCG1 EGF ELAVL1 C4BPA AREG BCL2L1 C4BPB CLU EEF1G SERPING1 EEF1A1 EEF2 JAG2 JAG1 ADAM10 CD19 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 ABCC8 C3 C4A C4B_2 GUCY2C CYP2R1 SI LCT H2BC18 BECN1 UVRAG SLC35A3 MAP1LC3B ISCU SLC1A1 SLC2A9 SLC3A1 SLC1A3 SLC3A2 SLC6A20 SLC6A19 SLC36A2 SLC6A14 ACOT2 SLC7A7 SLC7A9 ST6GALNAC2 PRKCSH ZDHHC20 NOS2 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 GOLGA7 ST3GAL1 ST3GAL2 ST3GAL3 GBP6 ST6GAL1 LARP1 EDEM2 MOGS GRPEL1 HYOU1 ZDHHC11 MED19 MGAT4C MED18 ZDHHC9 PQBP1 MGAT4A MED11 MGAT4B MED29 MAN1B1 MED28 ST6GALNAC3 MED22 ST6GALNAC4 MED21 ATL2 SRRT VPS33A VPS33B ZCRB1 SNRNP200 CORO1A G3BP1 G3BP2 CAMK4 FUS NACA ISY1 IL10 BCAS2 CD163 PLK2 CTNNBL1 RHBDF2 PRCC HNRNPA1 MYH9 HNRNPA0 HNRNPA3 GPKOW CNBP CDC5L RBPJ KDELR1 CCAR1 CD2BP2 PCBP1 PCBP2 RBM10 MED13L BST2 CALM3 RETREG1 CALM2 SUGP1 DHX15 DHX16 UFD1 ARIH1 SFTPD BCAP31 TXNIP PEX19 NLRP12 HNRNPA2B1 IL17F IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG PPIB RTN3 DDX3X DDX46 DDX42 SFN RBM17 SUN2 DYNLT1 BUD31 MMP9 SFPQ RBM22 DDX23 RRBP1 SMNDC1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM HNRNPK NPLOC4 HNRNPF HNRNPD CLINT1 MED16 SF3B4 MED15 SF3B5 MED17 SF3B2 SF3B3 MED12 SF3B6 MED14 SF3B1 MED13 SF3A3 HEY1 SF3A1 SF3A2 MED10 XAB2 PHF5A HEY2 HSPA1B CLEC4M AUP1 IPO7 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 MED27 P4HA2 MED26 P4HA3 RCAN3 EIF4G3 MED23 EIF4G2 MED25 EIF4E3 MED24 DUSP16 PTBP1 MED20 PLRG1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 VPS41 EGFR NPIPB3 VPS45 PPIL3 PPIL4 PPIL6 SRRM2 AQR HLA-H HLA-C HLA-F CRNKL1 HLA-G MBD3 HLA-E NMI PRPF19 CHMP1A HHAT TOMM70 IL17RC IL17RA TLR1 HNRNPH1 GATAD2B HNRNPH2 GATAD2A TLR6 TLR2 SPCS3 SPCS2 SPCS1 CWC25 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 OAS2 LTF GBP2 GBP4 NHERF4 KMT2D FOXO6 FOXO4 FOXO1 MED30 MED31 S100A1 CD36 G6PC1 TIRAP PTEN ITGA4 CYP27B1 CYP11B1 GCLC GCLM CCNC TRIM28 TGFA ZMYM2 SNW1 CTSL NPM1 GCK MAMLD1 IRAK1 CHD4 CHD3 YWHAQ CYP17A1 MTA2 REST KRAS MAML2 MAML1 HGSNAT NAPEPLD JUNB MED8 MED4 MED6 MED7 CARS1 NEDD4L NCOR2 KAT2B KAT2A TAL1 GPS2 FGFR3 SYVN1 ITGA2B OPN1LW NRBP1 NOTCH2 NOTCH3 NOTCH4 ABL1 CDK8 MC2R SIN3A FMO3 HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC7 TXNRD1 PML HDAC10 HDAC11 TWIST1 PRMT1 GP1BA SMAD2 SMAD4 SMAD3 SLC17A8 ESR2 NR4A1 YBX1 PAH AXIN1 THBS1 ERBB2 HES1 PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 PORCN ARRB2 RAP1B JAK2 BRAP WDCP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 VCL MAP3K11 BAG4 F12 KLKB1 OPLAH SLC40A1 HEPH SLC11A2 ATP6V1H CP ZBP1 TBK1 IRF3 SLC9A6 SLC9A9 BCKDK BCKDHA DBT BCKDHB DLD HDLBP AP2A1 AP2A2 PRKACG PRKACB IL10RA AP2M1 CUBN AMN PDGFB AP2S1 ABCA1 AP2B1 P4HB IDH1 ENO1 OMD TALDO1 HSPG2 PPP1R3C NHLRC1 SDC4 SDC2 SDC3 GNS CHST14 EXT1 EXT2 B4GAT1 SDC1 GBE1 KHK GYS2 GYS1 CHST6 GAA ALDOB CHST3 PAPSS2 PAPSS1 GPC1 GPC3 SLC17A5 GOLGB1 GPC2 GPC5 GPC4 GPC6 ALG11 FMOD AGRN NAGLU GYG2 GYG1 EPM2A KERA SLC26A2 DCTN1 TKFC GCKR ABCA12 SLC4A4 BSG SLC39A4 B3GALT6 SLCO2A1 SLC27A4 G6PC3 ABCB6 ABCB4 SLC5A2 OGN SLCO1B1 SLCO1B3 SLC33A1 SLC6A5 GALK1 SLC26A4 SLC26A3 ABCD4 SLC6A2 B4GALT1 SLC22A12 SLC2A10 SLC2A1 ABCC6 LMBRD1 SGSH SLC29A3 HK1 SLC24A4 SLC20A2 ABCB11 SLC35A2 SLC16A1 SLC24A5 SLC37A4 PGM1 DCXR B4GALT7 GALT PRELP ACAN CHSY1 B3GAT3 LUM GALNS RPIA GALE PC GALM TICAM1 TRAF3 CD14 IKBKE FLT3LG HNRNPU MTA1 MTA3 APRT PNP PRF1 FOXM1 ADA ICOS ABCG8 ZC3HC1 ABCG5 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 PRKG2 CYP26B1 CYP26C1 MAOA ALK EML4 RDH5 PPM1B HIP1 PRKAR1A BCL11A EIF2AK3 STRN BIRC6 OGG1 NTHL1 NEIL3 NEIL1 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 CSF2RB VPS25 CSF2RA VPS28 CHMP5 TUFM CSNK1A1 OPN1SW CD209 ITGB1 CYFIP1 CYP11A1 RHOG ELMO2 DOCK2 DOCK1 RAB7A ERBIN TBXAS1 PPP1CB PPP1CA ABCA4 PMM2 MPI PTK2 ABCA3 DAG1 DPAGT1 ALG8 ALG9 PRKAR2A ALG6 ALG2 ALG3 NRP1 ALG12 ALG1 MPDU1 RFT1 PABPC1 CXCR4 MYO9B CYP11B2 CYP21A2 NCK1 SLC35C1 DHDDS DPM1 DPM2 DPM3 GNE NEU1 CTSA NUS1 SLC35A1 SRD5A3 GFPT1 DOLK TMPRSS2 ACE2 HAVCR1 ELK1 EREG BTC EPGN HBEGF SQSTM1 ARF1 HSPA8 MTRR AHCY MTR MAT1A COMT KLB IRS1 PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 ABCC2 CUX1 FGFR1OP2 IL6R MYO18A CPSF6 KEAP1 UBE2L6 HERC5 RNF213 ATG7 PDGFRB TRAT1 NTRK3 PIK3AP1 TRIM4 TTR KIF5B LMO7 CUL5 UBA7 UBA6 UBA5 UBR4 UBA3 UBA1 VHL PPFIBP1 HGF PATJ PALS1 CRB3 GSS CTBP2 CTBP1 NCKAP1 BRK1 CYBA BCR NOXO1 NCKAP1L WASF1 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX1 C1QBP DNMT3B DNMT3A PRIM2 DNMT1 PRIM1 POLA1 POLA2 MCL1 PDGFRA SLC2A2 SLC5A1 SLC6A3 PSENEN PSEN2 IL22 PSEN1 APH1A NCSTN APH1B HES5 HEYL SLC67A1 HCK CD8B ELMO1 OPN1MW UPK1A EPCAM CYFIP2 WIPF1 WIPF2 WIPF3 GNAT3 C3AR1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK MEFV PRKAR2B PLCG2 MYO5A ARPC1B ARPC1A WASL CTSG SYK GNAI3 ADCY4 WAS ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 NT5E PYCARD IGHG3 IGHG4 IGHG1 CYSLTR1 IGHG2 CYSLTR2 GGT1 DPEP2 DPEP1 GNAZ NCKIPSD DVL1 DVL2 DVL3 NLRP3 GGT5 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 FCGR3A ACTR3 ACTR2 FGR MYH2 ADORA2B FCGR1A WASF3 MYO10 P2RX7 P2RX4 FCGR2A MYO1C SUGT1 TRIM27 TNKS TNKS2 LIG1 CD9 NRG1 CYP7B1 PSMD8 IKBKB PSMD6 CYP27A1 TCN2 PSMD7 PSMD2 DUSP10 PSMD3 PSMD1 IKBKG BTRC DUSP8 MAP3K7 DUSP9 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 PSMA7 MYD88 RELA SLC24A1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 IRAK4 SEM1 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 TLR10 PSMC3 TLR5 PSMC4 PSMC1 PSMC2 NFKBIB NOD1 NOD2 HDAC4 IRAK2 UBE2I NR3C1 ESR1 TENT4A KIAA1549 MPRIP TRIM24 AGTRAP AP3B1 SND1 SUMO1 ESRP1 AKAP9 KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 MRE11 LMNA BRCA1 AGK QKI BRCA2 CLCN6 KAT5 FAM131B EXO1 AGGF1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 LRAT WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RBP4 RPA1 RPA2 PALB2 RAD50 RAD51 RBP1 RPA3 RAD17 RAD1 ATM RAD9B ATR RAD9A RDH12 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 HGS CTNNB1 EPS15 CBLL1 MET STAM2 SH3GL2 SH3GL1 TUBB SHC1 YWHAB NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 FRS2 BRAF MAPK14 EXOC1 SOS1 CRK SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC GBF1 HDAC3 LY96 HBB TRIP11 CEP43 XPO1 STRA6 HMOX1 EP300 TBL1X MED1 RLBP1 CREBBP APOA1 HBA2 NCOR1 TBL1XR1 TLR4 GCC2 NFE2L2 GOLGA4 PPIA FKBP1A CALM1 CAST COG1 YWHAE APP JUN FASLG SOD2 CDC25C FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 SLC5A7 NOTCH1 RBX1 IHH GNGT1 SHH GNGT2 WNT5A DHH GP9 GP1BB GP5 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 XRN1 STAT5A STAT5B PIM1 NOX4 GRB2 FZD5 CYP2U1 FZD4 WNT3A CYP1B1 FZD7 KDM1A FZD6 FKBP4 DDX5 FZD8 GNG12 GNG11 GNG13 GNB2 KANK1 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 SPRED3 SPRED2 SPRED1 CUL3 NF1 IDUA HEXB NCAN HEXA BGN SPTBN1 DCN BCAN MSN VCAN GLB1 HYAL1 CSPG5 IDS CSPG4 GUSB ARSB CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 FLT3 NUP107 PPP1CC PPP2R1B PPP2R1A FGFR2 DYNC1LI1 DYNC1LI2 CLIP1 NUP160 NUP85 RPS27 PPP2R5E SEC13 NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 DYNLL2 DYNC1I2 PPP2CA PPP2CB NUP43 DYNC1I1 RANBP2 DYNC1H1 TAOK1 ACAT1 NUP37 FEN1 MSH6 MSH2 MSH3 PMS2 MLH1 AVPR1B AVPR2 EIF4A2 EIF4A1 AVP AVPR1A TJP1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 H2AC17 ERCC2 H2AC12 MNAT1 FDX1 H2AC1 FDXR FDX2 H2AC19 H2AC25 H2AC14 H2AC21 H2BC12L UNC93B1 AKT2 TLR8 TLR7 MYC AKT3 TLR3 AKT1 CSNK2A1 CSNK2A2 CSNK2B MASP1 MBL2 RPN2 C1QA MAPKAP1 RPN1 PIK3R3 C1S PIK3R2 PIK3R1 PIK3R6 PIK3R5 CGAS LYN LRRFIP1 YES1 IRF7 H4C9 DHX9 ERLIN1 ERLIN2 MOV10 AGO3 AGO4 XRCC6 XRCC5 H2AC20 AGO1 RNF43 AGO2 STING1 CD28 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage GSDMD CASP3 CASP4 IL18 IL1B TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX TNRC6A TNRC6B ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 TP53 UBE2D1 ANAPC10 ANAPC11 IL6 CDC23 UBE2S CDC26 RELA CDC27 CDC16 VENTX ANAPC4 ANAPC5 ANAPC1 ANAPC2 CEBPB NFKB1 CTNNB1 CSF1R CDKN2A FZR1 EHMT2 CCND1 EHMT1 LEF1 MOV10 TCF7L2 AGO3 AGO4 AGO1 TNRC6C CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) DHCR7 TM7SF2 SC5D MSMO1 HSD17B7 NSDHL EBP CYP51A1 DHCR24 LBR LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism HYKK SLC25A21 PIPOX CRYM DLD AASS GCDH ALDH7A1 AADAT PHYKPL DLST DHTKD1 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade ANO5 APP F5 F8 SERPINE1 GPC1 F12 KLKB1 GPC3 GPC2 PRTN3 GPC5 F7 GPC4 F9 GPC6 PROZ AGRN GP1BA F3 PROS1 SERPINC1 F10 F2 PROC SERPINE2 SERPINA5 THBD SERPING1 SMPD1 PF4V1 CD177 PROCR F11 GP9 GP1BB HSPG2 GP5 F2R SDC4 SDC2 SDC3 KNG1 SERPINA10 SDC1 ADAMTS13 SERPIND1 VWF PF4 ANO6 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing OGG1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 SYT10 INS TNRC6A TNRC6B REST NAMPT NPAS4 MDM2 CDK5 FOS CDK5R1 XPO1 PLK2 GEM ARNT ARNT2 SRF CREBBP RBFOX3 BDNF MAPK1 IQSEC3 MAPK3 NR3C1 BMAL1 MOV10 AGO3 RET AGO4 KCNIP3 AGO1 AGO2 TNRC6C STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLG TWNK MGME1 EXOG SSBP1 POLRMT POLG2 RNASEH1 TOP3A COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation LAMB3 COL9A2 COL6A5 PPIB LAMA3 LAMC2 MMP9 LOX COL1A1 LOXL3 COL1A2 LOXL4 PLEC LOXL1 LOXL2 MMP20 P4HB P4HA1 CTSV P4HA2 P4HA3 CTSL CD151 MMP13 ADAMTS2 ADAMTS3 MMP7 COL17A1 COL18A1 COLGALT2 PLOD3 CTSS PXDN COL15A1 COL16A1 PLOD2 PLOD1 CTSB COL13A1 COL14A1 COLGALT1 P3H2 COL11A1 P3H1 COL11A2 COL12A1 PCOLCE P3H3 COL19A1 COL10A1 PCOLCE2 SERPINH1 COL28A1 CRTAP COL26A1 COL27A1 COL24A1 COL25A1 MMP3 COL22A1 COL23A1 ADAMTS14 COL3A1 COL2A1 COL4A2 ITGB4 COL5A1 COL4A1 COL7A1 COL6A2 BMP1 COL5A3 TLL2 COL4A4 TLL1 COL5A2 COL6A1 ITGA6 COL4A3 COL4A6 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRND CHRNG CHRNE CHRNB2 CHRNB4 CHRNA3 CHRNA4 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 RAP1A GAB1 RAPGEF1 MET HGF CRK DOCK7 RAP1B RAC1 CRKL FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate AKR1A1 CRYL1 XYLB DCXR SORD RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions CBFB CLDN5 RUNX1 TJP1 OCLN TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 LGALS3 PPARGC1B CCNB1 CDK1 COL1A1 SRC YAP1 UCMA RB1 CDKN1A CCND1 HIVEP3 HEY1 ABL1 STAT1 SKP2 HEY2 MAPK1 MAPK3 ITGBL1 CDK4 ESRRA MMP13 SATB2 BGLAP HDAC3 GSK3B MSX2 PPARGC1A BMP2 HDAC6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RBM14 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BAX STUB1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 MAF PSMA7 TWIST2 CBFB TWIST1 PSMB6 RUNX1 PSMB7 SOX9 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 DLX5 PSMC6 DLX6 PSMC3 PSMC4 PSMC1 PSMC2 IHH HDAC4 NR3C1 ESR1 SMAD1 SMAD4 AR SMURF1 SMAD6 GLI3 GLI2 SP7 AKT2 AKT3 AKT1 NKX3-2 HES1 ZNF521 HAND2 ITGA5 PPM1D WWP1 WWTR1 YES1 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation INS IRS1 IRS2 GRB10 INSR REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling CHUK CASP8 LRRC14 USP14 NLRX1 UBA52 TP53 NLRC5 TRAF2 USP18 N4BP1 IKBKB UBB TRAF6 UBC IKBIP IKBKG RPS27A CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions PARVB FLNC LIMS2 LIMS1 ITGB1 FBLIM1 ILK FERMT2 ARHGEF6 ACTN1 FLNA VASP PXN TESK1 RSU1 PARVA ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC TUBA4B TUBA4A CCT6A TUBA8 TUBA1C TUBA1B TUBA1A CCT3 CCT2 TUBB2B TUBB2A TCP1 TUBAL3 TUBA3E TUBA3D TUBA3C CCT8 CCT7 CCT5 CCT6B CCT4 TUBB6 TUBB3 TUBB1 TUBB4B TUBB4A REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP CASP8 TNFRSF10B TNFRSF10A TNFSF10 FAS FASLG TRAF2 RIPK1 FADD TRADD FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation FGF9 FGF20 FGF18 FGF1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling CSF3 SYK UBA52 UBE2D1 ELOB ELOC TYK2 JAK1 UBB RNF7 UBC RPS27A CUL5 STAT5A STAT5B HCK SOCS3 SOCS1 JAK2 UBE2D2 STAT1 LYN STAT3 UBE2D3 CSF3R ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway HLA-B HLA-A B2M HLA-H HLA-C HLA-F HLA-G CTSV CTSS HLA-E CTSL LNPEP PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis CAD UMPS DHODH ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones MBTPS2 MBTPS1 ATF6B HSPA5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen GP1BA FCER1G ITGB1 GP6 ADAMTS13 GP9 GP1BB ITGA2 LYN ITGA1 GP5 VWF FYN ITGA10 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism RMND5B LDHA MAEA PDPR RMND5A PDK4 PDK3 UBA52 NEK1 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 ARMC8 PDP1 DLD UBB MKLN1 GID4 PDP2 UBC GSTZ1 GID8 RPS27A ME1 RANBP9 WDR26 PDHB INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing GSDMD RELA CASP1 CTSG IL18 IL1A IL1B NFKB1 NFKB2 KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins KIF5C CENPE KIF5B KIF5A KIFAP3 KIF28P KIF12 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF4B KIF1A KIF4A KIF25 KIF18A KIF6 KIF27 KIF9 KIFC2 KIF16B KIFC1 KIF3B KIF20B KIF3A KIF20A KLC1 KIF18B KLC4 KIF26B KLC3 KLC2 KIF3C KIF11 KIF15 KIF2A KIF2C KIF2B KIF23 KIF22 RACGAP1 KIF26A VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus HSPA1A METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 ODC1 PSMD11 PSMD14 PSMD13 AGMAT SAT1 PSMA7 PSMB6 SMS PSMB7 AZIN2 PSMB4 AZIN1 PSMB5 PSMB2 PSMB3 PSMB1 AMD1 ADRM1 SEM1 PSMC5 SRM PSMC6 PSMC3 PSMC4 PSMC1 NQO1 PSMC2 PAOX PSMD8 PSMD6 PSMD7 PSMD2 OAZ1 PSMD3 OAZ2 PSMD1 OAZ3 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation SERPINA1 PPP6C TFG PPP6R1 PPP6R3 TMED2 ARF4 CTSC TRAPPC2L LMAN1L MAGT1 F5 F8 TRAPPC6A TBC1D20 ACTR1A TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A DERL1 ANKRD28 DERL2 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A OS9 TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 CNIH3 FOLR1 BET1 TUSC3 AREG RNF139 TMEM258 DCTN2 UGGT2 VCP UGGT1 MARCHF6 DCTN3 EDEM3 SEL1L AMFR RNF103 TRIM13 OST4 GBF1 OSTC STT3A STT3B RNF185 DDOST DAD1 COL7A1 ARFGAP1 RNF5 ARFGAP3 COG8 COG7 COG6 COG5 COG4 INS COG3 COG2 COG1 NAPA NAPB LMAN1 GOLGA2 NAPG STX5 YKT6 FUCA1 ST6GALNAC2 PRKCSH FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 MGAT1 GMPPB PMM1 CHST8 MGAT2 GMPPA CGA ST3GAL1 PMM2 ST3GAL2 MPI ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C ARF5 MGAT4A MGAT4B ARCN1 MAN1B1 ST6GALNAC3 ST6GALNAC4 DPAGT1 ALG8 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 ST3GAL6 CD55 KDELR2 B4GALNT2 UBXN1 ARFGAP2 KDELR1 MIA2 SYVN1 ENGASE ST6GALNAC1 CMAS NANP FPGT NGLY1 PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 SLC35C1 ALG5 GOSR1 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 ANK2 GNE ANK3 UAP1 ANK1 NPL FUOM ALG10B NEU2 NEU3 NEU4 DHRSX CHST10 GOLGB1 SLC17A5 GMDS SPTBN4 AMDHD2 SPTBN5 NEU1 ST8SIA4 ASGR1 SPTA1 ST8SIA5 ST3GAL5 ASGR2 ST8SIA6 SPTBN1 COPZ2 SPTBN2 CTSA COPZ1 NUS1 ALG11 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 GLB1 ST8SIA3 SRD5A3 MAN1A2 GFPT1 MAN1C1 DOLK MAN1A1 NAGK FCSK DOLPP1 SPTAN1 SPTB KDELR3 DCTN1 ARF1 CTSZ FUT3 EDEM1 BET1L MVD SEC23A NSF SAR1B MANEA GRIA1 LHB SEC24B DYNC1LI1 SEC24A DYNC1LI2 UMOD B4GALT2 B4GALT3 MLEC B4GALT1 TMED3 SEC24D TMED7 SEC24C TMED9 HK1 CALR B4GALT6 SEC13 COPG2 COPG1 ALG10 COPB2 COPA B4GALT4 B4GALT5 DYNLL1 PDIA3 COPB1 ST6GALNAC6 MAN2A2 TMEM115 DYNLL2 COPE CANX RAD23B DYNC1I2 DYNC1I1 UBA52 DYNC1H1 ALG14 ALG13 DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 UBB UBC RPS27A PSMC1 CAPZB CAPZA1 MGAT3 CAPZA2 CSNK1D MIA3 RPN2 RPN1 ARF3 MCFD2 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling JAK1 STAT3 IL6R SOCS3 JAK2 PTPN11 IL6ST IL6 CBL STAT1 TYK2 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL NODAL DAND5 FURIN PCSK6 ACVR2A FOXO3 MAPK1 FOXH1 DRAP1 GDF1 MAPK3 SMAD2 LEFTY1 ACVR1C SMAD4 CRIPTO3 SMAD3 CRIPTO ACVR1B LEFTY2 ACVR2B CFC1 CER1 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation H2AC6 H2AC7 H2AX DNMT3L DNMT3B DNMT3A DNMT1 H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 UHRF1 H2BC1 H4C9 H2AB1 H2AZ2 H2AC20 H2AC8 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response CYCS AVEN DIABLO CARD8 UACA CASP3 MAPK1 CASP7 APIP MAPK3 XIAP CASP9 APAF1 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling JAK1 PTPN6 IFNG PTPN1 PIAS1 SOCS3 SOCS1 IFNGR1 JAK2 IFNGR2 PTPN11 SUMO1 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 PLCG1 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily H2AX DDX46 DDX42 RBM17 MYOG CDC73 MYOD1 TCF4 H3-3B SUPT16H SMNDC1 U2SURP SKIC8 H3C8 CTR9 RTF1 H2AJ CHD2 LEO1 PAF1 H3C15 SSRP1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 H2BC9 SF3A1 H2BC8 SF3A2 H2BC5 PHF5A H2BC3 H2BC1 SNRPN CHERP H2AB1 H2AC8 H2AC6 H2AC7 SNRPA1 PUF60 SNRPB2 SNRPD2 TCF12 SNRPD1 SNRPD3 H2AC19 SNRPG H2AC14 H2BC12L SNRPE SNRPF SNRPB H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CHD1 TCF3 DHX15 H4C9 H2AZ2 H2AC20 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling ERBB2 NRG1 NRG2 GRB7 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal ASCC2 ASCC3 ALKBH2 MGMT ALKBH3 FTO ALKBH5 ASCC1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway TUBB2B TUBB2A TUBA4B TUBA4A TUBAL3 ARL2 TUBA3E TBCD TBCC TBCB TBCA TUBA3D TUBA3C TBCE TUBB6 TUBA8 TUBB3 TUBB4B TUBA1C TUBB1 TUBB4A TUBA1B TUBA1A REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand GSDMD TLR1 S100A1 TLR6 APOB CD36 TLR2 LBP S100A9 S100A8 GSDME FGB FGA FGG TLR4 LY96 TLR7 CD14 HMGB1 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells LPO MPO ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases TIMP2 TIMP1 MMP13 FURIN MMP8 SPOCK3 PRSS2 CTSG MMP14 MMP16 MMP9 KLKB1 MMP7 COL18A1 PLG KLK2 PRSS1 CTRB2 CTRB1 MMP25 MMP24 CMA1 TPSAB1 MMP3 MMP10 MMP11 MMP15 MMP17 MMP1 CTSV CTSK MMP2 ELANE INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO7 ANO4 FURIN ANO5 ANO2 TMPRSS2 ANO3 ANO1 ACE2 ANO10 ANO8 ANO9 ANO6 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 FGF9 FGF20 FGF23 FGF16 FGF18 PIK3R1 PIK3CA GAB1 FRS2 FGF1 FGF2 PTPN11 FGF4 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 PCNA UBA52 RFC5 RFC3 RPA1 RPA2 RFC4 UBB RFC1 REV3L RFC2 UBC RPA3 RPS27A REV1 MAD2L2 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade GUCY2F NMT1 CALM1 PRKCQ NMT2 PRKCA PDE6B SLC24A1 PDE6A RHO PDE6G SAG CNGA1 RCVRN GNAT1 PPEF1 CNGB1 METAP1 METAP2 CAMKMT RGS9BP GNGT1 GNB1 GRK1 GUCA1B GUCA1A FNTA GUCY2D GUCA1C GRK7 FNTB APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 HMGA1 PPIA PSIP1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage CASP3 CASP7 CYCS XIAP CASP9 APAF1 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation PTPN3 ARHGEF7 UBA52 EGFR UBB SH3GL3 SH3KBP1 UBC RPS27A STAM CBL HGS PTPRK EPS15 TGFA STAM2 SH3GL2 SPRY1 SH3GL1 SPRY2 EREG BTC EPGN HBEGF EPS15L1 EPN1 CDC42 EGF AREG PTPN12 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B ROBO1 RHOA SLIT2 VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance VLDLR APOC1 LSR APOB APOC4 APOBR CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF5 TIAM2 YWHAE OBSCN ARHGEF4 ARHGEF7 ARHGEF26 UBA52 NGEF ARHGEF6 FGD1 FGD2 RAC1 KALRN GNA13 FGD3 FGD4 BCL2L11 ARHGEF33 ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 AATF VAV1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B MAPK8 NGFR SQSTM1 CASP3 TIAM1 NGF SOS1 VAV3 CASP2 VAV2 RASGRF2 ARHGEF18 ARHGEF10L BAD AKAP13 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 BEX3 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 ECT2 PREX1 SOS2 MCF2L NET1 TRAF6 ITGB3BP ABR ARHGEF16 ARHGEF40 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFB8 NDUFAF2 SFXN4 NDUFAF3 MT-ND6 NDUFAF1 MT-ND4 TMEM186 MT-ND5 MT-ND2 MT-ND3 ACAD9 MT-ND1 NDUFA5 DMAC1 DMAC2 ECSIT TIMMDC1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 NDUFA10 HSPA9 NDUFB10 NDUFB11 OXA1L NDUFV3 NDUFV2 NDUFV1 COA1 NDUFC2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 NDUFAB1 HSCB PYURF TMEM126A TMEM126B NDUFS3 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation HBB HBA2 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family PLCG2 FCER1G SYK MUC12 MUC13 MUC15 CLEC10A CLEC4A CLEC4C CLEC4D CLEC4E MUCL1 CLEC6A MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 LYN MUC4 MUC6 MUC16 MUC17 FYN MUC19 MUC5B MUC20 MUC21 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy TBK1 TOMM40 UBE2V1 UBA52 MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN UBC RPS27A TOMM70 TOMM20 UBE2L3 TOMM22 UBE2N MAP1LC3A MTERF3 ATG9A VDAC3 ATG12 VDAC2 ATG5 VDAC1 UBE2D2 SQSTM1 UBE2D3 PRKN PINK1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 KAT2B MNAT1 KAT2A TBP MBD3 RRN3 TTF1 ERCC6 GATAD2B UBTF GATAD2A POLR1A POLR1B POLR1E POLR1F MTA1 POLR1G HDAC1 POLR1H HDAC2 EHMT2 TAF1D MTA3 POLR1C TAF1B TAF1C TAF1A POLR1D CHD4 RBBP4 CCNH CHD3 RBBP7 POLR2E POLR2F POLR2H RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation ZNF521 UCMA GLI3 SATB2 RB1 HEY1 BGLAP ABL1 MAF HEY2 WWTR1 MAPK1 HDAC3 HDAC6 SP7 YES1 CBFB MAPK3 COL1A1 SRC AR HES1 YAP1 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation MIXL1 CTNNB1 NANOG POU5F1 TRIM33 TCF7 LEF1 FOXH1 SMAD2 SOX2 SMAD4 EOMES SMAD3 TBXT TBPL2 BMP4 GSC SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease GAB1 HRAS SOS1 PLCG1 FRS2 PIK3CA PIK3R1 FGFR4 NRAS NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins SYT10 DBNL SYT2 SYT1 STX1A GRIN2B SHARPIN EPB41L3 CASK LIN7A LIN7C LIN7B EPB41L1 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 GRIN2C DLGAP1 DLGAP3 DLGAP2 GRIN2D DLGAP4 GRIN1 DLG3 BEGAIN GRIN2A DLG4 DLG2 APBA3 APBA2 SYT7 GRM1 LRRTM3 GRM5 LRRTM4 LRRTM1 LRRTM2 SYT9 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 PDLIM5 NLGN4Y NLGN4X SYT12 APBA1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions PARD6G PARD6B PRKCI CLDN2 PATJ F11R PALS1 CLDN6 CRB3 PARD6A CLDN4 CLDN3 PARD3 CLDN9 CLDN8 CLDN7 CLDN22 CLDN20 CLDN23 CLDN1 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 CLDN5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements PSMA5 PSMA6 PSMA3 DIS3 PSMA4 PSMA1 PARN NUP214 PSMA2 EXOSC7 UBA52 EXOSC6 EXOSC5 PSMD12 EXOSC4 PSMD11 EXOSC9 KHSRP PSMD14 HSPA1A PSMD13 EXOSC8 EXOSC3 EXOSC2 PSMA7 EXOSC1 PSMB6 PSMB7 PSMB4 TNPO1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 EIF4G1 YWHAZ PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 YWHAB SET ANP32A TNFSF13 ELAVL1 MAPK14 HSPA8 MAPK11 MAPKAPK2 PRKCD PRKCA HSPB1 AKT1 PABPC1 XRN1 XPO1 DCP1A DCP2 ZFP36 PSMD8 ZFP36L1 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members STAT3 BCL2L11 BMF BID PMAIP1 BCL2 BBC3 BAD BCL2L1 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer TP53 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) LYN EPO GAB1 PIK3CD IRS2 PIK3CA PIK3R1 PIK3CB JAK2 PIK3CG PIK3R5 EPOR FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis CD3G RAC1 VAV1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 IGHG3 IGHG4 IGHG1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 WASF3 MYO10 MYO1C SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TYW2 TRMT5 TYW1 LCMT2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS LYN EPO HRAS RAPGEF1 SOS1 VAV1 IRS2 SHC1 JAK2 EPOR CRKL NRAS DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 AMN CBLIF CUBN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation PPP2CA PPP1CC PPP2CB PPP2R1B PPP2R1A CALM1 CAMK2B CAMK2D CAMK2A SRC CAMK2G PPP2R5E PHB1 ARAF PPP1CB PPP2R5B PPP2R5A PPP2R5D JAK2 PPP2R5C YWHAB BRAP MARK3 NRAS MRAS KSR1 SHOC2 HRAS MAP2K1 MAP2K2 RAF1 BRAF MAP3K11 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins TNRC6A TNRC6B CDH19 SP1 ZC3H12A ZEB2 ANGPTL4 CTNND1 HEYL CTNNB1 SOX10 PRDM8 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 JUP ADAM19 ILF3 CDH11 SNAI1 MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling HSP90AA1 CDC37 ERBIN ERBB2 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs CASP3 CASP7 CYCS XIAP CASP9 DIABLO APAF1 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling JAK1 STAT3 CRLF1 CANX IL27 IL27RA EBI3 JAK2 IL6ST STAT1 TYK2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 MUC1 MUC2 MUC12 MUC7 MUC13 MUC4 MUC6 MUC15 MUC16 MUC17 MUC19 MUC5B MUCL1 MUC20 MUC21 MUC3A MUC5AC GALNT12 MUC3B DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions BTK PLCG2 TYROBP SOS1 VAV3 CD300E SYK SIRPB1 RAC1 VAV2 CD300LB HLA-B KLRK1 B2M HLA-C KLRD1 KIR2DS2 HLA-E PIK3CB KIR2DS4 KIR2DS5 NCR2 PIK3R2 PIK3R1 SIGLEC16 PIK3CA TREM2 SIGLEC15 KLRC2 LCK NRAS TREM1 HRAS SIGLEC14 CLEC5A PLCG1 FYN LCP2 KIR3DS1 GRAP2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ACR SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly MTTP APOC1 APOB P4HB APOC4 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ABCD1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 ABCA1 ABCA12 ABCG8 ABCG5 ABCB6 VCP ABCB4 ABCC9 SEL1L ABCA3 ABCD4 ABCC6 LMBRD1 RNF185 ABCB11 KCNJ11 ABCC8 ABCC2 APOA1 RNF5 ERLEC1 PSMD8 CFTR PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation RAP1A MAPK1 RAPGEF1 MAPK3 MAP2K1 MAP2K2 FRS2 BRAF NGF YWHAB CRKL RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription CDKN1A ZFHX3 TGFB1 SMAD4 TP53 SMAD3 RUNX3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CHEK2 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK3 MAPK14 MAPK11 CHEK1 CSNK1E CSNK1A1 NEK11 GSK3B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle ARHGAP22 ARHGAP20 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 TFRC ARAP1 FMNL1 FMNL2 LAMTOR1 PAK1 PAK3 PAK2 TIAM1 RASGRF2 PARD6A LBR ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 STARD8 CPNE8 DOCK8 SNAP23 FNBP1L DAAM1 FNBP1 DOCK10 SCRIB SYDE1 ARHGAP42 TRIO ARHGEF25 CDC42BPB ITSN1 CDC42BPA IQGAP3 ARHGAP1 GIT1 ARHGDIG STOM FMNL3 ARHGAP5 ARAP2 ARHGAP35 ECT2 PREX1 STARD13 ARAP3 OPHN1 JUP ARHGDIA BCR CDC42 MCF2L ARHGDIB ARHGAP17 TMPO ABR PLEKHG3 RACGAP1 ARHGEF16 DLC1 ARFGAP3 DEPDC1B PLEKHG2 CDC42EP1 ARHGEF15 GIT2 ARHGAP26 ARHGEF19 BAIAP2 ARHGEF5 RAB7A ARHGEF4 VAMP3 ARHGEF26 ARHGEF7 NGEF ARHGEF6 PLD1 FGD1 IQGAP2 FGD2 GNA13 ARHGAP39 ARHGAP21 FGD3 FGD4 SRGAP3 SRGAP2 YKT6 SRGAP1 PAK4 MCF2 DOCK7 KTN1 VANGL1 ARHGAP32 DIAPH3 STEAP3 WIPF1 WIPF2 WDR91 CAV1 WIPF3 WDR81 CDC42SE2 ARHGAP9 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 VAV3 WASL CHN1 FARP1 DEF6 WAS SHKBP1 VAV2 FAM13B GOLGA8R ARHGAP11B TAGAP PLEKHG4 PAK6 PLEKHG1 PAK5 ARHGAP10 ARFGAP2 MYO9B SPATA13 PIK3R2 IQGAP1 PIK3R1 SH3PXD2A PLEKHG4B ARHGAP44 DOCK11 ARHGAP40 RALBP1 MAP3K11 KCTD3 PREX2 ARHGAP45 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer FURIN CCNK CCNT2 TRIM33 CCNT1 CCNC UBA52 UBE2D1 MEN1 SERPINE1 PPM1A JUNB RNF111 COL1A2 UBB UBC RPS27A NEDD4L CDK9 CDKN2B HDAC1 ATP1B4 MAPK1 TFDP1 MAPK3 SNW1 TFDP2 SKIL SMAD2 SMAD4 SMAD3 SMURF2 SMAD7 CDK8 YBX1 NCOR2 SP1 RBL1 MYC USP9X EP300 SKI E2F4 PARP1 WWTR1 NCOR1 E2F5 UBE2D3 TGIF1 TGIF2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis POMC HSD3B2 CYP11B2 HSD11B1 CYP21A2 HSD11B2 HSD3B1 SERPINA6 CYP11B1 CYP17A1 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 GCK NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 GCKR AAAS DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination UBE2D1 USP34 MDM2 MDM4 CDK1 CCNA2 CCNA1 STAM HGS VDAC3 STAM2 VDAC2 VDAC1 H2BC9 H2BC8 NEDD8 H2BC5 H2BC3 H2BC1 H2AC8 H2AC6 H2AC7 VCP RHOA H2BC26 H2BC21 TOMM20 EP300 TAB1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CFTR TRAF6 AXIN2 H2BC18 CDC25A BECN1 IDE TAF10 USP30 IL33 RHOT1 POLB ACTB ADRB2 IFIH1 RNF135 TRIM25 PTRH2 MAVS TP53 RIGI KAT2B KAT2A ATXN7 BAP1 UCHL1 SENP8 SNX3 UCHL3 HCFC1 FOXK2 FOXK1 MBD5 OTUD7A MBD6 NLRP3 ASXL1 ASXL2 USP11 USP33 STAMBPL1 OTUD5 VCPIP1 UFD1 KDM1B MYSM1 OTUB1 USP13 TNKS OTUB2 TNKS2 RNF146 GATA3 OTUD3 TGFBR1 TNIP1 SUDS3 TGFBR2 TNIP3 USP17L4 USP17L5 USP17L8 RNF128 USP7 TADA2B USP2 WDR20 USP17L3 USP17L1 USP5 USP3 APC FKBP8 SKP2 STAMBP ACTL6A USP10 DDB2 CDC20 USP17L30 YOD1 MAT2B ZRANB1 USP17L21 TGFB1 USP17L20 USP17L22 USP17L2 TOMM70 USP17L15 USP9X USP17L18 RCE1 USP17L17 USP17L19 USP17L10 USP17L12 TADA3 USP17L11 USP17L13 TRAF2 RUVBL1 NFRKB USP37 ACTR5 USP47 USP48 RAD23A PSMD8 USP49 USP42 ACTR8 PSMD6 YY1 USP44 RAD23B BIRC2 PSMD7 INO80C BIRC3 PSMD2 PRKN INO80B PSMD3 INO80E USP16 PSMD1 INO80D USP12 IKBKG RIPK1 ABRAXAS2 USP19 KEAP1 MAP3K7 USP24 TFPT USP25 MCRS1 USP26 INO80 PSMA5 USP20 PSMA6 USP22 PSMA3 USP28 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 OGT PSMD11 PSMD14 PSMD13 RNF123 RIPK2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 TRAF3 UBB PSMB2 PSMB3 UBC SIAH2 PSMB1 RPS27A ADRM1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FOXO4 USP14 ATXN3L TRIM4 JOSD2 ATXN3 JOSD1 NOD1 NOD2 USP18 WDR48 TNFAIP3 OTUD7B TNIP2 ESR1 USP21 USP4 SMAD2 SMAD1 CYLD SMAD4 SMAD3 AR BRCC3 SMURF2 CLSPN BABAM1 BABAM2 UIMC1 SMAD7 ABRAXAS1 BRCA1 H2AC17 H2AC12 AXIN1 CCP110 H2AC1 USP15 H2AC19 H2AC25 H2AC14 H2AC21 PTEN MYC UCHL5 USP8 ARRB1 ARRB2 HIF1A MUL1 BARD1 TRRAP H2AC20 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events CALM1 PRKACG PRKACB PLCB4 MAPK1 GNAT3 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B PRKAR2B PRKACA PDE1C PDE1B PDE1A GNAI3 GNAL ADCY4 GRK2 PRKCD PRKCA NBEA PLA2G4A PLCB3 ADCY3 PLCB1 PRKX PLCB2 ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 GNAQ CAMK2A ADCY7 ADCY6 PRKAR2A ITPR1 GNAI1 ADCY5 ITPR2 GNAI2 ITPR3 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 GNA14 GNA15 GNA11 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) IDS FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct CTNNB1 PAX8 GATA3 LHX1 ID4 HOXB4 PCDH19 WFDC2 PLAC8 MECOM HOXA6 EMX2 OSR1 RET FGF2 NPNT PAX2 BMP4 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins POM121C NUP42 PHC2 NUP62 NUP43 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 RANBP2 PHC3 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 BMI1 RING1 NUP37 RNF2 L3MBTL2 ZBED1 HDAC1 SUZ12 HDAC4 UBE2I SATB1 PIAS1 NUP107 CBX5 SUMO1 SUMO3 SUMO2 SATB2 NUP160 NUP85 SEC13 NUP133 HDAC2 PCGF2 H4C9 CHD3 NUP205 POM121 NUP188 AAAS CBX8 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events MMGT1 MAGT1 ADD2 PIP RHCG RHBG ADD1 ADD3 LRRC8C RHAG LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 CTNS NIPAL2 NIPAL3 AZGP1 ANKH NIPA1 MRS2 TUSC3 NIPA2 SLC66A1 DMTN AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy ATM MTMR14 PRKAG1 HSF1 PRKAG2 RPTOR PRKAG3 TSC2 TSC1 RRAGA RRAGC RRAGB RRAGD MTMR3 ATG14 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 WIPI1 VDAC3 VDAC2 VDAC1 UBE2D2 SQSTM1 EEF1A1 HSPA8 TBK1 VCP UBE2V1 DYNC1LI1 DYNC1LI2 PCNT PIK3R4 HBB TOMM70 MLST8 TOMM20 UBE2L3 TOMM22 UBE2N ARL13B PIK3C3 DYNLL1 CETN1 PRKAA1 PARK7 HSP90AA1 PRKAA2 RNASE1 CHMP4C DYNLL2 CHMP4B GFAP HDAC6 LAMP2 CHMP3 UBE2D3 CHMP4A PLIN2 CFTR CHMP6 GABARAPL3 CHMP7 ATG3 GABARAPL1 ATG9B PRKN ATG10 DYNC1I2 ATG13 ATG101 ATG16L2 ATG16L1 MTOR WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B CHMP2B ATG4A CHMP2A ATG4D TOMM40 DYNC1I1 WDR45B AMBRA1 UBA52 DYNC1H1 BECN1 UVRAG MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN ATG7 UBC RPS27A MAP1LC3A GABARAP FUNDC1 USP30 ATG9A ATG12 PEX5 ATG5 NBR1 GABARAPL2 PLIN3 ULK1 HSP90AB1 PRKAB2 IFT88 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B EPAS1 MTERF3 TSG101 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 PINK1 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 PPP2CA PPP2CB PPP2R1A SOS1 UBA52 KLB UBB FGF1 FGF2 UBC FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF16 MKNK1 FGF19 FGF18 SPRY2 PIK3R1 PIK3CA FGFR4 NRAS GAB1 MAPK1 FRS3 HRAS MAPK3 PLCG1 FRS2 BRAF PTPN11 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway TNFRSF10B TNFRSF10A FAS FASLG UNC5A DAPK1 MAGED1 TICAM2 UNC5B TICAM1 DAPK2 LY96 DAPK3 CD14 APPL1 CASP9 TRADD CASP8 TNFSF10 TRAF2 DCC CASP3 TLR4 RIPK1 FADD MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters SLC17A5 SLC5A8 SLC25A1 SLC25A11 SLC25A10 SLC5A12 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 SOD3 TKT PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PRDX1 PSMB5 UBB SLC7A11 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NOTCH1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PGD PSMC2 CDKN2A ABCG2 SQSTM1 ABCC1 IDH1 EGF BCL2 PDGFA AREG BCL2L1 TALDO1 SP1 GSTA1 GSK3B MYC BACH1 G6PD ATF4 HMOX1 EP300 NQO1 GSTA3 CREBBP GCLC MAFG PRKAA2 GCLM SRXN1 CHD6 ME1 ABCC3 PSMD8 MAFK PSMD6 PSMD7 PSMD2 NFE2L2 PSMD3 TXN PSMD1 TXNRD1 BTRC KEAP1 CCL2 SKP1 ABCF2 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling IFNA8 PTPN6 IFNAR1 IFNA21 IFNA14 IFNA16 IFNA17 IFNB1 IFNA10 SOCS3 SOCS1 TYK2 USP18 JAK1 STAT2 PTPN1 IFNA5 IFNA4 IFNA7 IFNA6 PTPN11 IFNA1 IFNA2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres FBLN2 FBLN5 TGFB2 MFAP5 ITGAV MFAP4 VTN MFAP3 MFAP2 LTBP4 LTBP2 LTBP3 LTBP1 ITGB8 TGFB1 ITGB6 TGFB3 ITGB5 BMP4 ITGA8 GDF5 ITGB1 ITGB3 BMP7 BMP2 EFEMP2 EFEMP1 BMP10 FBLN1 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis ALDH9A1 SHMT1 TMLHE BBOX1 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer PTEN INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling MAPK8 IL1RL2 IL1RAPL1 IL1F10 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway MAPK1 MAPK3 MAP2K1 MAP2K2 RAF1 BRAF RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination ZNF473 SNRPD3 NCBP1 SNRPG NCBP2 CPSF1 CSTF3 CPSF4 SNRPE CPSF3 CSTF2 CPSF2 SNRPF CSTF2T WDR33 SNRPB NUDT21 PCF11 CLP1 CSTF1 FIP1L1 PAPOLA SYMPK CPSF7 LSM10 SLBP LSM11 PABPN1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation FGF9 FGF20 FGF23 KLB FGF16 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET2 TET1 TDG TET3 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription EZH2 H2AX FOXA2 H3-3B TWIST2 TWIST1 H3C8 H2AJ H3C15 ZMYM2 RB1 HDAC1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 H2BC1 SMARCA4 MPHOSPH8 MAPK3 FOXQ1 SNAI2 H2AB1 TLE1 ZBTB33 H2AC8 H2AC6 PKM H2AC7 KLF9 MCRIP1 FOXJ2 STRAP FOXP2 TCF12 SP1 ARID1A H2AC19 H2AC14 H2BC12L ZEB2 ZEB1 H2BC26 H2BC21 CTBP2 CTBP1 EED H2BC17 H2BC12 TFAP2A H2BC13 H2BC14 H2BC15 KDM1A HDAC2 H2BC11 SIRT1 TCF3 H4C9 SNAI1 RBBP4 RBBP7 H2AZ2 H2AC20 KMT5A ZNF217 TGIF2 KLF4 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling TNRC6A TNRC6B RXRB MYLIP NCOR2 SCD HDAC3 UGT1A3 ANGPTL3 GPS2 ABCG1 CETP NRIP1 EP300 KDM4A TBL1X FASN NCOA1 KDM1A ABCA1 APOC4 NR1H3 APOE PCK1 NCOR1 APOC2 NR1H2 TBL1XR1 APOC1 KDM3A KDM1B FABP6 APOD ARL4C EEPD1 MOV10 AGO3 AGO4 PLIN1 RXRA AGO1 ABCG8 AGO2 ABCG5 TNRC6C REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 ODC1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 AZIN1 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NQO1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 OAZ1 PSMD3 OAZ2 PSMD1 OAZ3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA LINGO1 MAG MCF2 OMG RTN4 RHOA NGFR DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system STRA6 RDH12 OPN1LW LRAT RLBP1 OPN1MW TTR NAPEPLD ABCA4 RBP4 RDH5 OPN1SW RBP1 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism NMNAT2 PARP6 NMNAT1 PARP4 PARP16 NUDT12 PARP9 PARP14 SLC25A51 NNMT PARP8 NADK PARP10 NADK2 NAPRT NAMPT NAXE NAXD NT5E NADSYN1 SLC5A8 BST1 QPRT SLC22A13 NMRK2 NMRK1 CD38 RNLS NMNAT3 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain F8 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle GIT2 WWP2 EPHA2 ARHGEF7 ARHGEF6 ARHGAP31 ARHGAP30 SRGAP2 PAK4 ITSN2 SPTBN1 PEAK1 PARD6A SRC VANGL1 STAM USP9X HGS PAK1 MYO6 STAM2 RHOU PAK3 SPTAN1 PIK3R2 IQGAP1 PAK2 CLTC PIK3R1 NCK2 GIT1 NCK1 TXNL1 CDC42 WDR6 PTK2B DST DEPDC1B DLG5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation HADHB HADHA PCTP ACADL ACAD11 ACAD10 THEM4 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 ACSF2 DBI MECR ECI1 ACADM DECR1 ECHS1 ACSM3 MCEE NDUFAB1 ACSM6 PCCA HADH MMAA ACOT2 ACADS PCCB MMUT ACOT9 ACOT7 ACOT1 MCAT ACOT7L ACADVL THEM5 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling CASP3 BEX3 YWHAE NGF NGFR CASP2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair RAD1 ATM ACD RAD9B ATR H2AX RAD9A CETN2 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 RNF4 TERF2IP RCHY1 ERCC6 MAPK8 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 VCP COPS5 FAAP100 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 FAAP24 FAAP20 H2BC11 FANCM FANCL FANCA FANCB H2AZ2 FANCE FANCG FANCF ELL CHEK2 RNF111 CENPX MGMT RBX1 TCEA1 POLB ACTB APEX1 XRCC1 LIG3 TRIM25 TP53 DCLRE1C RIF1 LIG4 PAXIP1 NHEJ1 XRCC4 SMARCA5 PPP5C TDP2 TDP1 BAP1 ISY1 UBXN1 GPS1 POLL BAZ1B APBB1 KDM4A POLQ MDC1 EYA1 EYA2 POLM EYA3 EYA4 COPS4 COPS2 UFD1 UBE2T KDM4B PPIE LIG1 USP7 NPLOC4 XAB2 ABL1 ACTL6A CDK2 USP10 REV3L SIRT6 PCLAF FANCI POLI DDB2 USP43 REV1 KPNA2 MAD2L2 SPRTN FANCC AQR ERCC8 PARG ADPRS PRPF19 ISG15 PNKP RUVBL1 NFRKB PARP1 PARP2 ACTR5 USP45 RAD23A CHD1L ACTR8 YY1 RAD23B INO80C INO80B INO80E INO80D XPA COPS7B COPS7A XPC UBE2L6 TFPT MCRS1 INO80 COPS3 ALKBH2 COPS6 ERCC4 HERC2 ERCC1 ERCC5 COPS8 UBA52 DCLRE1B MPG DCLRE1A FAN1 POLN UBB UBC CENPS RPS27A FEN1 MSH6 SEM1 MSH2 MSH3 PMS2 MLH1 PIAS4 PIAS3 UBE2I WDR48 FANCD2 USP1 UBE2B CUL4A CCNH DDB1 DTL RAD18 POLR2A PPP4R2 PIAS1 POLR2B CUL4B TIPIN POLR2C TIMELESS POLR2D ALKBH3 BRCC3 POLR2E PPP4C FTO POLR2F ALKBH5 CLSPN SUMO1 POLR2G TP53BP1 SUMO3 POLR2H ASCC1 BABAM1 SUMO2 ASCC2 POLR2I BABAM2 ASCC3 POLR2J UIMC1 POLR2K RNF168 POLR2L ABRAXAS1 GTF2H1 MUS81 RNF8 NSD2 GTF2H2 MRE11 BRCA1 RAD52 BRCA2 GTF2H3 EME1 KAT5 GTF2H4 EXO1 GTF2H5 EME2 CDK7 FIRRM CHEK1 ERCC3 NBN ERCC2 MNAT1 TOPBP1 POLK POLE POLH H2AC19 GEN1 H2AC14 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 TOP3A UBE2V2 HUS1 SPIDR RAD51B UBA7 RAD51D OGG1 RAD51C DNA2 NTHL1 RHNO1 TDG MBD4 BLM RTEL1 SMUG1 NEIL3 PCNA NEIL2 RAD51AP1 NEIL1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 ZNF830 H4C9 XRCC2 TINF2 PRKDC XRCC3 UVSSA RPA1 RPA2 PALB2 POLE4 RAD50 XRCC6 RAD51 XRCC5 H2AC20 RPA3 POLE2 POLE3 RAD17 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD AHCY MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors CHRM1 CHRM4 CHRM5 CHRM2 CHRM3 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 ITCH UBA52 SPARC UBB PSENEN PSEN2 SRC PSEN1 UBC APH1A YAP1 NCSTN RPS27A APH1B EREG BTC HBEGF SHC1 APOE NRAS HRAS S100B EGF ESR1 NEDD4 GABRG3 GABRG2 PGR SOS1 ADAM17 NRG2 GABRB3 NRG3 GABRB2 NRG4 EGFR GABRB1 DLG4 MXD4 NRG1 CSN2 STMN1 STAT5A ADAP1 TAB2 CXCL12 WWOX PIK3CA PIK3R1 GABRQ GABRA1 WWP1 NCOR1 GFAP BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB HADHA ACADL ECHS1 HADH NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance ACHE SLC6A4 MAOA TOMT SLC6A3 BCHE ALDH2 SLC22A2 COMT SLC22A1 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes EZH2 H2AX ASH2L SMARCB1 EPC1 JMJD6 SMARCC1 SMARCC2 H3C8 KDM6B H2AJ H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 RIOX2 SMARCA2 SMARCA4 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 PBRM1 KMT2A KMT2C BRWD1 ATF2 NFKB2 PRMT5 WDR77 HDAC3 SMARCD3 ARID2 DPY30 H2BC26 H2BC21 WDR5 EP300 EED TBL1X H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 H2BC15 NCOA2 CREBBP H2BC11 NCOR1 TBL1XR1 CARM1 CHD4 RBBP4 CHD3 RBBP5 CLOCK RBBP7 H2AZ2 H2BC18 MTA2 REST PHF20 DNMT3A TAF9 KDM4C PAX3 TAF12 TAF10 HDAC1 SETD1B SETD1A KDM5A ACTB KDM6A PADI2 ING5 BRD1 NCOR2 KAT2B KAT2A ATXN7 GPS2 KDM4A HCFC1 KDM1A KDM3A KDM1B KDM4B ARID4A ARID4B MEAF6 SAP30 YEATS4 BRMS1 PHF21A SUDS3 RCOR1 HMG20B SAP30L TADA2B SAP18 KAT6A JADE1 JADE3 JADE2 KAT7 SUPT20H ATXN7L3 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 CCND1 ENY2 TAF5L DMAP1 MRGBP TADA1 ING4 ING3 VPS72 MSL2 MSL3 SUPT3H ACTL6B CDK4 MSL1 TAF6L ACTL6A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 KAT8 MBD3 MBIP KAT14 DR1 TADA2A ZZZ3 GATAD2B GATAD2A YEATS2 TADA3 SGF29 SMARCD1 KANSL1 HDAC2 KANSL2 SMARCD2 KANSL3 RUVBL1 HDAC8 SMARCE1 KMT5A MCRS1 RPS2 USP22 PHF2 KDM5C HDAC10 KDM3B KDM5D PHF8 UTY KDM2A OGT KDM2B PADI3 KDM4D PADI4 ARID5B PADI1 PADI6 RELA PRMT6 KMT2D NFKB1 PRMT1 KMT2B MTA1 PRDM16 MTA3 SMYD2 KDM7A BRPF1 BRPF3 NSD2 KDM5B KAT5 SUV39H2 SETD2 H2AC17 SETD3 H2AC12 PRDM9 SETD6 PRMT7 SUV39H1 PRMT3 RUVBL2 ARID1A DOT1L H2AC1 ARID1B SETD7 COPRS H2AC19 H2AC25 NSD3 H2AC14 H2AC21 MECOM NSD1 KMT5B SMYD3 ATF7IP SETDB1 KMT5C SETDB2 ASH1L AEBP2 SAP130 EHMT2 JAK2 EHMT1 H4C9 TRRAP EP400 H2AC20 SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste KCNJ2 OTOP1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins ALOX15 LTA4H CYP1A2 CYP1A1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling PTPN6 SH2B3 SH2B2 SOS1 SOCS6 KIT SOCS1 PRKCA LCK LYN YES1 FYN CBL VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway FANCC ATR MUS81 ERCC4 ERCC1 DCLRE1B EME1 UBA52 DCLRE1A FAN1 EME2 POLN CENPX UBB SLX1B UBC FAAP100 CENPS RPS27A FAAP24 SLX4 FAAP20 WDR48 ATRIP FANCD2 USP1 UBE2T RPA1 FANCM RPA2 FANCL FANCA FANCI FANCB FANCE RPA3 FANCG FANCF CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 MAX PSMC5 PSMC6 PSMC3 PSMC4 RB1 PTK6 PSMC1 LIN54 CDKN1A PSMC2 CDKN1B CKS1B LIN52 LIN37 LIN9 CCND1 CABLES1 E2F1 WEE1 SKP2 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 CDK7 MNAT1 RBL2 AKT2 MYC AKT3 AKT1 E2F4 E2F5 PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria AUH DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD OPLAH SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus IP6K1 IP6K2 IPMK IPPK DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid PNLIPRP3 CEL LIPF CLPS PNLIPRP1 PNLIPRP2 PNLIP SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids ALOX5 GPX1 GPX4 PON3 PON2 PON1 ALOX5AP GPX2 LTC4S CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGHG3 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGKV1D-16 IGHG2 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CRP C1QB IGKV3-20 IGHV4-34 C1QA IGHV1-2 IGHV1-46 IGHV4-39 C1S IGHV C1R IGKV2-29 IGKV2-28 C1QC IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species TXNRD2 SOD3 ATOX1 SOD1 CCS CYCS SOD2 PRDX2 PRDX1 AQP8 GPX2 NUDT2 NCF1 NCF2 PRDX3 NCF4 PRDX6 NOX4 NOX5 GSTP1 ERO1A CYBB CYBA GPX1 P4HB GPX3 GPX6 TXN2 GPX5 GPX8 TXN GPX7 ATP7A TXNRD1 CAT G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase PPP2CA PPP2CB PPP2R1B PPP2R1A PPP2R2A UBA52 CDK7 CUL1 MNAT1 RBL2 RBL1 UBB UBC RPS27A CDKN1C RB1 CDKN2D PTK6 CDKN1A CDKN2B CDKN1B CKS1B CDKN2C CCND3 CDKN2A CCND2 CCND1 JAK2 E2F1 E2F2 ABL1 E2F3 E2F4 SKP2 LYN E2F5 PPP2R3B CDK6 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 SKP1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network RAC1 VAV1 SRC PIP5K1A PIP5K1B TGFA MET EREG BTC EPGN HBEGF NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 CD86 EGF CD80 FRS2 FLT3 AREG PPP2R1B PPP2R1A CD19 THEM4 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF IRS2 PIK3CD FGF1 FGF2 PIK3CB FGF3 PIK3CG NRG1 FGF4 FGF6 PIP5K1C FGF7 FGF9 FGF20 FGF23 PPP2R5E FGF22 GAB2 IRAK1 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A PIK3CA FGF10 PPP2R5D PPP2R5C LCK FYN TRAF6 RHOG PTPN11 PPP2CA PPP2CB INS PIP4K2A MYD88 PIP4K2B PDGFRA PDGFRB TRAT1 PDGFB IRAK4 NTRK3 PIK3AP1 IER3 PHLPP2 PHLPP1 FLT3LG KIT IL33 RAC2 IL1RL1 ESR1 ESR2 PTEN AKT2 AKT3 AKT1 ERBB2 STRN TRIB3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR CD28 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains CD4 HLA-DRB3 HLA-DRB1 CD3G CD3E CD3D TRAV19 HLA-DPA1 HLA-DRA TRBC1 HLA-DQB2 HLA-DQB1 TRBV12-3 TRBV7-9 PAG1 PTPRC LCK TRAV29DV5 HLA-DQA2 PTPN22 HLA-DRB5 TRAV8-4 HLA-DRB4 HLA-DPB1 CSK PTPRJ TRAC SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants STAT3 HRAS PDGFRA SOS1 PIK3R2 PIK3CA PIK3R1 PIK3CB NRAS STAT1 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia ARG1 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation HMOX1 SLCO1B1 SLCO1B3 ABCG2 UGT1A1 ABCC2 FABP1 UGT1A4 GSTA1 ALB ABCC1 HMOX2 BLVRB BLVRA METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD17B1 CGA LHB STS FDX1 FDXR HSD11B1 FDX2 HSD11B2 AKR1B15 HSD17B14 SERPINA6 HSD17B11 HSD17B2 HSD17B3 SRD5A3 HSD17B12 STARD3 HSD3B2 STARD4 CYP11B2 STAR CYP21A2 STARD6 HSD3B1 STARD3NL TSPO CYP11B1 AKR1B1 CYP11A1 TSPOAP1 POMC SRD5A2 SRD5A1 CYP17A1 CYP19A1 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R40 TAS2R8 TAS2R41 SCN9A TAS2R43 SCN1B TAS2R46 GRM4 TAS2R1 TAS2R30 CALHM3 PLCB2 TAS2R3 TAS2R31 TAS2R5 TAS2R4 TAS2R38 TAS2R39 SCN3A ITPR3 TAS1R2 TAS2R50 TAS1R1 GRM1 SCN2A TAS1R3 SCN2B TRPM5 TRPM4 SCN4B GNG13 TAS2R20 GNB1 GNAT3 TAS2R10 CALHM1 TAS2R13 GNB3 TAS2R14 TAS2R7 TAS2R16 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PPIE ERCC4 ERCC1 ERCC5 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 POLK POLE AQR ERCC8 RFC5 RFC3 RFC4 RFC1 RFC2 PRPF19 ISY1 PCNA POLD3 POLD4 POLD1 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 XPA RPA3 POLE2 POLE3 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction ATM ACD ATR H2AX SPAM1 SUN2 H3-3B SYCP2 SYCP1 SYNE2 H3C8 SYNE1 SUN1 TEX12 TERF1 TERF2 SMC1B H2AJ SYCE3 SYCE2 SYCE1 POT1 TERF2IP REC8 STAG3 SYCP3 CATSPER1 CATSPER3 H3C15 CATSPER2 CATSPER4 HVCN1 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 H2BC9 H3-4 H2BC8 ADAM30 ADAM2 H2BC5 ACR NANOS3 KCNU1 H2BC3 CBFA2T2 CATSPERB CATSPERD CATSPERG H2BC1 CD9 ZP1 ZP3 CDK4 ZP2 ZP4 CDK2 H2AB1 SMC3 H2AC8 H2AC6 H2AC7 B4GALT1 PRDM1 RAD21 STAG1 H2BC26 H2BC21 BMP4 STAG2 H2BC17 H2BC12 H2BC13 H2BC14 TFAP2C H2BC15 FKBP6 SMC1A H2BC11 TET2 HSPA2 H2AZ2 PDPN NANOG POU5F1 SPO11 TEX15 MSH4 DMC1 MSH5 PSMC3IP LMNB1 MND1 MLH3 MLH1 UBE2I MRE11 BRCA1 BRCA2 FIRRM PRDM9 NBN H2AC19 H2AC14 H2BC12L EOMES CXCR4 TOP3A SOX17 RAD51C BLM FIGNL1 RBBP8 H4C9 TINF2 RPA1 RPA2 RAD50 RAD51 H2AC20 RPA3 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RUNX3 MDM2 PSMA7 CBFB PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TGFB1 PSMB3 SRC UBC PSMB1 RPS27A ADRM1 SEM1 EP300 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMURF2 SMURF1 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 STAT3 NTRK1 NGF SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 SEPHS2 RPL5 SECISBP2 RPL30 EEFSEC RPL3 SEPSECS RPL32 PSTK RPL31 RPL34 SARS1 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A4 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A10 SLC39A2 SLC39A1 SLC39A14 SLC39A3 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants ITGA2B FN1 SRC ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B YWHAB MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport SERPINA1 PPP6C GOSR1 TFG PPP6R1 PPP6R3 TMED2 ARF4 CTSC TRAPPC2L LMAN1L ANK2 ANK3 F5 ANK1 F8 TRAPPC6A TBC1D20 ACTR1A TRAPPC6B GORASP1 PREB GOLGB1 SEC22B SPTBN4 SEC22A SPTBN5 SEC22C SPTA1 RAB1A TMED10 LMAN2L SPTBN1 COPZ2 STX17 SPTBN2 COPZ1 GOSR2 RAB1B USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SPTAN1 SEC23IP CNIH1 SPTB KDELR3 CNIH2 CNIH3 DCTN1 FOLR1 BET1 ARF1 CTSZ BET1L AREG SEC23A NSF SAR1B GRIA1 DCTN2 DCTN3 SEC24B DYNC1LI1 SEC24A DYNC1LI2 GBF1 TMED3 SEC24D TMED7 SEC24C TMED9 SEC13 COPG2 COPG1 COPB2 COPA COPB1 DYNLL1 TMEM115 COL7A1 COPE DYNLL2 ARFGAP1 DYNC1I2 ARFGAP3 COG8 COG7 COG6 COG5 COG4 INS COG3 COG2 COG1 DYNC1I1 NAPA DYNC1H1 NAPB DCTN6 LMAN1 GOLGA2 DCTN5 NAPG STX5 DCTN4 YKT6 CAPZA3 ACTR10 CAPZB CAPZA1 CAPZA2 ARF5 ARCN1 CSNK1D CD55 KDELR2 MIA3 ARFGAP2 KDELR1 MIA2 ARF3 MCFD2 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors TBXA2R PTGFR PTGIR PTGER4 PTGDR2 PTGER2 PTGER3 PTGER1 PTGDR CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine MAOA TOMT SLC6A3 COMT ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex MCM6 MCM2 H2AX ANAPC15 ANAPC16 KPNA1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 H3-3B CDC16 ANAPC4 ORC5 H3C8 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 H2AJ ORC3 ORC2 H3C15 FZR1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 CDC6 KPNB1 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 KPNA6 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L H4C9 MCM7 H2AC20 MCM3 MCM4 MCM5 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP16 DUSP6 DUSP7 JAK2 PEA15 IL6 TYK2 JAK1 MAPK1 CDK1 MAPK3 MAP2K1 MAP2K2 IL6R DUSP10 DUSP5 DUSP2 DUSP1 PTPN11 DUSP4 DUSP8 DUSP9 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors HCAR2 HCAR3 HCAR1 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling PTPRZ1 MDK ALK PTN PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression SLC27A1 CCNC PPARGC1B CYP1A1 AHRR MED9 CDK19 ACADM MED16 MED15 MED17 MED12 MED14 MED13 MED10 UGT1A9 HMGCS1 SREBF2 MTF1 MED27 MED26 ESRRA G0S2 FHL2 MED23 MED25 FADS1 MED24 TNFRSF21 MED20 FDFT1 CDK8 ABCB4 RXRB NFYA NFYB NFYC ANKRD1 SP1 GRHL1 HDAC3 SMARCD3 ACSL1 CHD9 PEX11A CPT2 NPAS2 HELZ2 TGS1 EP300 TBL1X PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 NR1H4 TBL1XR1 PLIN2 CARM1 CYP7A1 BMAL1 CLOCK TXNRD1 ALAS1 TIAM2 SULT2A1 HMGCS2 APOA2 APOA5 MED8 ANGPTL4 MED4 MED6 MED7 ARNT2 ABCA1 RGL1 MED30 NR1H3 MED31 FABP1 NR1H2 RORA CPT1A RXRA PPARG AGT PPARA CD36 MED19 MED18 THRAP3 MED11 MED29 FAM120B MED28 NCOR2 MED22 MED21 GPS2 TRIB3 ARNT CYP4A11 MED13L ME1 NCOA3 GLIPR1 NRF1 AHR TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 CPSF1 CPSF3 EIF4E CPSF2 WDR33 NUP37 FIP1L1 SYMPK NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 SLBP THOC6 SRRM1 DDX39A NUP107 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 NUP160 CHTOP ALYREF UPF3B MAGOHB NXF2B NUP85 CPSF4 RNPS1 SEC13 NUP133 NUP205 POM121 NUP188 AAAS VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 THTPA SLC19A3 SLC19A2 TPK1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism ASAH2 STS ARSA NEU2 NEU3 GALC SUMF2 SUMF1 HEXB NEU1 HEXA SMPD3 GLB1L3 SMPD2 CTSA GLB1L2 ARSL GLB1L ASAH1 GLB1 GBA3 ARSJ GBA2 GM2A ARSK ARSH ENPP7 ARSI ARSF ARSB GLA ARSG ARSD PSAP GBA1 SMPD4 SMPD1 M6PR DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b MPI THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex CSNK1E CRY2 CRY1 PER2 PER1 KMT2A PER3 BMAL1 CSNK1D CLOCK NPAS2 CREBBP BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ACADM ECHS1 HADH REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway CHST10 CHST8 MGAT2 CGA FUCA1 FUT3 LHB FUT8 MAN2A1 MAN2A2 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants SOS1 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS ERBIN PLCG1 EGF ERBB2 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking CFTR GOPC DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a MGAT2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism ALDOB PPP2CA POM121C ALDOA PPP2CB NUP42 NUP62 NUP43 TPR NUP88 RAE1 PFKL NUP214 RANBP2 GNPDA1 PRKACG NDC1 PC NUP210 GNPDA2 NUP155 PRKACB PFKM NUP153 PFKP NUP93 NUP50 NUP35 NUP54 PGK1 NUP37 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK1 GPI NUP107 PGK2 ENO1 GCKR ENO2 SLC37A1 ENO3 ENO4 PPP2R1B PPP2R1A G6PC2 G6PC3 PRKACA G6PC1 GAPDHS GCK ADPGK HK2 NUP160 HK1 HK3 NUP85 SLC37A4 PCK2 BPGM HKDC1 SEC13 GAPDH NUP133 FBP1 FBP2 PPP2R5D TPI1 PGAM1 PGAM2 PGM2L1 NUP205 POM121 NUP188 ALDOC AAAS REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO NTN1 SLIT1 ROBO1 SLIT3 NELL2 ROBO2 SRC DCC SLIT2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants FLT3 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses IFIH1 PPIH TBK1 TRIM25 FKBP1A PPIG ITCH IRF3 PPIB SIKE1 MAVS UBA52 RIGI NPIPB3 RELA KPNB1 RUNX1 TRAF3 PYCARD UBB TLR7 IKBKE UBC NMI RPS27A TOMM70 NFKB1 NFKBIA CASP1 NLRP3 RIPK3 PCBP2 BST2 IRAK2 SFTPD TKFC TRAF6 RCAN3 PPIA KPNA2 STING1 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state PSMA5 PSMA6 ITCH PSMA3 PSMA4 PSMA1 PSMA2 CUL3 UBA52 PSMD12 PSMD11 GLI1 CDC73 PSMD14 KIF7 PSMD13 GPR161 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 HHIP PSMC4 BOC SPOP PSMC1 GAS1 PSMC2 CDON IHH NUMB SHH SMURF2 SMO SMURF1 GLI3 GLI2 DHH GRK2 CSNK1A1 KIF3A ARRB1 PTCH1 SUFU ARRB2 ULK3 PSMD8 DZIP1 SPOPL PSMD6 EVC2 PSMD7 IQCE EFCAB7 PSMD2 PSMD3 EVC PSMD1 DRC4 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis PPP2CA PPP2CB PTPN6 CALM1 KCNMB1 KCNMA1 LRP8 PDE2A PAFAH2 PTGIR PDE11A GUCY1B2 PDE10A GUCY1B1 NOS3 GUCY1A2 GNGT1 GUCY1A1 GNGT2 P2RX6 P2RX5 NOS2 P2RX3 P2RX2 P2RX1 MAPK14 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PPP2R1B PPP2R1A NOS1 PDE1B PRKG2 PDE1A PLA2G4A STIM1 ORAI2 ORAI1 GNG10 GNG3 ITPR1 GNG2 ITPR2 PECAM1 GNG5 ITPR3 GNG4 GNG7 SRI GNG8 ATP2B4 ATP2B3 PPP2R5E ATP2B2 ATP2B1 APOB SLC8A3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TRPC7 TRPC6 FGR TRPC3 PDE5A KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 IRAG1 P2RX7 GNB2 PDE9A P2RX4 GNB1 GNAS GNB4 GNB3 PTPN11 GNB5 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LIPC LDLR LDLRAP1 APOE TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation TNF CCNC RELA MED9 MED8 ANGPTL4 MED4 MED6 CDK19 MED7 CEBPB NFKB1 LPL MED16 MED15 MED17 MED12 CCND3 MED14 MED13 MED30 MED10 PCK1 MED31 FABP4 SREBF2 CDK4 MED27 NR2F2 MED26 PLIN1 RXRA MED23 MED25 MED24 MED20 PPARG PPARA CDK8 CD36 CEBPD EBF1 MED19 EGR2 ADIRF MED18 THRAP3 MED11 ZNF638 MED29 FAM120B MED28 NCOR2 ZNF467 ADIPOQ MED22 LEP MED21 HDAC3 SMARCD3 CHD9 TGFB1 HELZ2 WNT1 TGS1 WNT10B EP300 TBL1X PPARGC1A NCOA1 MED1 NCOA2 SLC2A4 CREBBP NCOA6 MED13L NCOR1 NCOA3 TBL1XR1 CARM1 CEBPA KLF5 KLF4 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor GNGT1 GNG10 GNGT2 PTGIR GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNAS GNG8 GNB4 GNB3 GNB5 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway LIG1 POLE PARG RFC5 RFC3 ADPRS RFC4 RFC1 RFC2 FEN1 PCNA POLD3 POLD4 POLD1 POLD2 PARP1 PARP2 POLB APEX1 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs MYCN TNRC6A TNRC6B MYC MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C CDH1 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization DKK2 EZH2 H2AX ASH2L SMARCB1 MYOG CHD8 MYOD1 TCF4 EPC1 JMJD6 H3-3B SMARCC1 SMARCC2 H3C8 KDM6B H2AJ CTNNB1 H3C15 BICRAL BICRA BRD9 SUZ12 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 H2BC3 CHD5 IKZF1 RIOX2 IKZF2 SMARCA2 SMARCA4 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 PBRM1 KMT2A KMT2C BRWD1 SNRPD2 ATF2 SNRPD1 NFKB2 SNRPD3 PRMT5 WDR77 HDAC3 SNRPG SMARCD3 CHD9 SNRPE ARID2 SNRPF DPY30 SNRPB H2BC26 H2BC21 WDR5 EP300 EED TBL1X H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 H2BC15 NCOA2 CREBBP H2BC11 NCOR1 TCF3 TBL1XR1 CARM1 MAFK CHD4 RBBP4 CHD3 RBBP5 CLOCK NFE2L2 RBBP7 H2AZ2 AXIN2 H2BC18 MTA2 REST PHF20 DNMT3A SUPT16H TAF9 KDM4C PAX3 TAF12 TAF10 SSRP1 HDAC1 BCL11B SETD1B SETD1A PHF10 KDM5A ACTB KDM6A PADI2 ING5 BRD1 TCF12 NCOR2 KAT2B KAT2A ATXN7 IGF2 GPS2 BRD7 KDM4A HCFC1 ADNP2 KDM1A ADNP CHD1 DHX15 KDM3A KDM1B KDM4B ARID4A ARID4B MEAF6 SAP30 YEATS4 BRMS1 PHF21A SUDS3 RCOR1 DDX46 DDX42 RBM17 HMG20B SAP30L TADA2B SMNDC1 SAP18 U2SURP KAT6A JADE1 JADE3 JADE2 KAT7 SUPT20H SF3B4 ATXN7L3 SF3B5 SF3B2 SUPT7L SF3B3 MORF4L1 SF3B6 KAT6B SF3B1 MORF4L2 SF3A3 HAT1 SF3A1 CCND1 ENY2 SF3A2 TAF5L DMAP1 PHF5A MRGBP TADA1 ING4 ING3 VPS72 MSL2 MSL3 SUPT3H SNRPN ACTL6B CDK4 MSL1 TAF6L CHERP ACTL6A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 SNRPA1 PUF60 SNRPB2 KAT8 MBD3 MBIP KAT14 DR1 TADA2A ZZZ3 GATAD2B GATAD2A YEATS2 TADA3 SGF29 CHD7 NKD2 FBP1 FAM124B SMARCD1 KANSL1 HDAC2 KANSL2 SMARCD2 KANSL3 RUVBL1 CBX1 HDAC8 SMARCE1 KMT5A MCRS1 RPS2 USP22 PHF2 KDM5C HDAC10 KDM3B KDM5D PHF8 UTY KDM2A OGT KDM2B PADI3 CDC73 KDM4D PADI4 ARID5B PADI1 PADI6 RELA SKIC8 CTR9 RTF1 CHD2 LEO1 PRMT6 KMT2D NFKB1 PAF1 PRMT1 KMT2B MTA1 PRDM16 MTA3 UBE2I SMYD2 CBX3 SUMO1 BCL7A KDM7A BRPF1 BCL7C DPF1 BRPF3 BCL7B DPF2 NSD2 DPF3 G6PC1 KDM5B SS18 SS18L1 KAT5 SUV39H2 SETD2 H2AC17 SETD3 H2AC12 PRDM9 SETD6 PRMT7 SUV39H1 PRMT3 RUVBL2 ARID1A DOT1L H2AC1 ARID1B SETD7 COPRS H2AC19 H2AC25 NSD3 H2AC14 H2AC21 MECOM H2BC12L NSD1 KMT5B SMYD3 NR2C2 ATF7IP SETDB1 BCL11A KMT5C SETDB2 ASH1L AEBP2 SAP130 NQO1 EHMT2 JAK2 EHMT1 CTCF CHD6 H4C9 TRRAP EP400 H2AC20 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse MYH9 MYL12B NGEF MYH11 LYN YES1 MYH14 MYH10 FYN MYL6 RHOA ROCK1 MYL9 ROCK2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide UBE2D1 RCHY1 RPL4 NPLOC4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 UBE2D2 RPL18A RPL36AL RPL36 RPL35 RPL38 RPL37 RPL39 RPL21 VCP RPL23 RPL22 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPL39L RPL41 RPL3L RPL27A RPLP1 RPLP0 ANKZF1 RPL7A KLHDC10 RPLP2 TCF25 NEMF RPL13A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPL14 RPL13 RPL15 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 PSMD12 PSMD11 ELOB RPL26L1 PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LTN1 CUL2 UFD1 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription NR3C1 REST SRF KCNIP3 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly CEP83 DYNLRB2 DYNLRB1 IFT25 CEP89 CEP57 ARF4 C2CD3 CETN2 PLK1 CEP164 PKD2 PKD1 IFT52 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CNGA2 CDK1 BBS9 CNGA4 BBS7 TNPO1 IFT57 CEP290 NINL IFT56 BBS5 CC2D2A BBS4 RAB8A OFD1 DYNLT5 IQCB1 MKKS EXOC8 DYNLT2 IFT140 EXOC7 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 RP2 BBS12 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 EXOC5 NEK2 IFT46 SFI1 EXOC2 SDCCAG8 EXOC1 IFT70B PPP2R1A IFT70A DCTN2 SSNA1 DCTN3 DYNLT2B ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 CEP152 WDR19 GBF1 CSNK1E KIF17 SCLT1 RAB11A ATAT1 NEDD1 TTC8 ALMS1 TRIP11 CEP162 B9D1 CEP41 CEP43 CLUAP1 YWHAG ARL13B INPP5E PDE6D DYNLL1 HSP90AA1 CKAP5 DYNLL2 HDAC6 MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 YWHAE DYNC1H1 NDE1 RHO B9D2 CNGB1 CPAP SMO AKAP9 PRKAR2B TUBA4A PRKACA DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CCP110 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CEP131 CSNK1D IFT80 CYS1 TUBA1A RPGRIP1L LZTFL1 CCT3 IFT88 CCT2 IFT81 UNC119B ARL6 ARL3 FBF1 MCHR1 TCP1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B CEP70 NPHP1 CEP72 NPHP3 CEP192 NPHP4 KIF3C MARK4 CEP76 RAB11FIP3 CCT8 CEP78 PLK4 CCT5 BBS2 CCT4 BBS1 ODF2 RAB3IP TUBB4B IFT122 TUBB4A BBIP1 IFT20 AHI1 IFT22 MKS1 IFT27 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MALSU1 MRPS18A MIEF1 MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MTRFR MRPL43 MTRES1 MRPL44 MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 PLCG1 NGF TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL2 RHOC RAC1 SEMA4D LIMK2 LIMK1 RRAS MYH14 CDK5 MYH10 PLXNB1 DPYSL4 DPYSL5 CDK5R1 DPYSL3 PLXNC1 SEMA6A SEMA6D SEMA7A PAK1 MET MYL12B PLXNA2 PLXNA3 PAK3 PTPRC FES PAK2 PLXNB3 TREM2 MYH11 SEMA3A SEMA3E FARP2 SEMA4A MYL6 PLXNA4 CD72 SEMA5A TYROBP CFL1 CRMP1 NRP1 GSK3B RHOA HSP90AB1 ERBB2 ROCK1 ROCK2 ARHGEF11 PIP5K1C ARHGEF12 MYH9 RHOB ITGB1 ARHGAP35 RND1 HSP90AA1 ITGA1 PLXNA1 PLXND1 FYN TLN1 MYL9 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 CYP4F22 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling APOA2 APOC2 LPL APOA4 APOB APOA5 GPIHBP1 APOA1 APOE APOC3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle GLS GAD1 GAD2 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC5A7 SLC1A7 SLC38A2 SNAP25 SYT1 VAMP2 SLC6A12 STX1A CASK HSPA8 LIN7A LIN7C LIN7B ABAT ARL6IP5 UNC13B SLC6A13 SLC6A11 SLC22A2 SLC22A1 SLC6A1 SLC18A2 SLC18A3 SLC32A1 MAOA SYN3 SYN2 SYN1 ALDH5A1 SLC17A7 RAB3A RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 NAAA CHAT CPLX1 DNAJC5 GLS2 TSPOAP1 APBA1 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation NOSTRIN DNM2 NOS3 NMT1 CALM1 NOSIP WASL NMT2 CYB5B HSP90AA1 LYPLA1 CYGB DDAH1 ZDHHC21 CAV1 SPR AKT1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion FFAR1 GNA11 GNAQ GNA14 PLCB3 GNA15 PLCB1 PLCB2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEK2 BUB1B CDC20 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 M PHASE%REACTOME%R-HSA-68886.5 M Phase H2AX ANAPC15 CEP57 ANAPC16 ANAPC7 CETN2 UBE2C PLK1 CEP164 UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A PCM1 CCNB1 GORASP1 CDC23 UBE2S CDC26 CNTRL CDC27 H3-3B ARPP19 CDC16 RAB1A NCAPH2 CDK1 NCAPG2 H3C8 ANAPC4 NIPBL ANAPC5 ENSA ANAPC1 TNPO1 NCAPD3 ANAPC2 RAB1B H2AJ USO1 RAB2A CEP290 NINL CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL GORASP2 OFD1 MCPH1 PPP2R2D H3C15 TUBB HAUS4 KIF20A HAUS3 H2BC9 HAUS6 H3-4 H2BC8 HAUS5 TUBG1 H2BC5 H2BC3 HAUS2 MAPK1 HAUS1 H2BC1 SET KIF23 CEP63 H2AB1 NEK2 SFI1 H2AC8 SDCCAG8 H2AC6 H2AC7 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E NEDD1 ALMS1 CEP41 CEP43 XPO1 H2BC26 H2BC21 YWHAG H2BC17 H2BC12 H2BC13 ANKLE2 H2BC14 H2BC15 PTTG1 H2BC11 EMD H2AZ2 LEMD3 RCC1 YWHAE LMNB1 GOLGA2 SMC4 SPAST SMC2 CC2D1B SIRT2 TUBGCP2 NCAPG TUBB8 NCAPH IST1 VRK1 TUBGCP5 LEMD2 TUBGCP6 TUBB8B TUBGCP3 TUBGCP4 ESPL1 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 NCAPD2 TUBB6 TUBB3 TUBB1 LPIN1 LPIN2 LPIN3 PRKAR2B TUBA4B PPP2R2A TUBA4A TUBA8 TUBA1C TUBA1B TUBA1A FBXO5 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NEK9 NEK6 NEK7 RB1 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 KPNB1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 LBR KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 HSP90AA1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 CHMP4A BIRC5 PSMD8 KIF2C CHMP6 KIF2B CHMP7 PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA KMT5A AURKB NSL1 CENPC PPP2CA PRKCB PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CHMP2B CLASP1 PSMA4 DYNC1I1 CHMP2A PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 RAN NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 CPAP PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2I SUMO1 AKAP9 PRKACA PRKCA FIRRM CCP110 CEP250 H2AC19 CDK5RAP2 H2AC14 H2BC12L CEP135 EML4 CEP131 CSNK1D CSNK2A1 CSNK2A2 CSNK2B CEP70 CEP72 VPS4A CEP192 CEP76 CEP78 PLK4 H4C9 ODF2 H2AC20 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 PNRC2 EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 PPP2R1A RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 PPP2CA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 NCBP1 NCBP2 UPF1 RPS27A EIF4A3 CASC3 MAGOH PPP2R2A RBM8A GSPT2 GSPT1 UPF3B UPF3A MAGOHB RNPS1 UPF2 PABPC1 DCP1A ETF1 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJA10 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GJD4 GJB2 GJD3 GJB1 GJC1 GJD2 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs TNRC6A TNRC6B AGO3 AGO4 AGO1 AGO2 TNRC6C NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 NEURL1 MDK UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B CNTN1 NOTCH2 MIB2 NOTCH2NLA NOTCH2NLC NOTCH2NLB BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B FRAT1 FRAT2 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G3 PLA2G4B PLA2G6 PLA2G2A PLA2G4F PLA2G4E LPCAT4 PNPLA8 PLA2G10 PLA2G4C MBOAT2 PLAAT3 PLA2R1 LPCAT3 PLBD1 PLA2G4A ABHD4 PLAAT1 PLAAT2 PLAAT5 PLA2G1B PLAAT4 PLA2G5 MBOAT1 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 OGG1 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism ENPP1 RFK SLC52A2 SLC52A3 SLC52A1 FLAD1 ACP5 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME CYP3A4 SLCO1B1 SLCO1B3 UGT1A3 PON3 ABCC2 ABCB1 PON1 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells FGF10 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF EP300 CBFB RUNX1 KRAS TGFB1 BRD2 CCND1 HDAC4 RUNX3 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance HDLBP PCSK9 AP2A1 LIPA AP2A2 LIPC UBA52 LDLRAP1 AP2M1 MYLIP CUBN VLDLR AMN LSR NPC1 SOAT1 SOAT2 UBB NPC2 UBC RPS27A CES3 APOB AP2S1 LDLR CLTC CLTA APOC4 NR1H3 APOE APOA1 APOBR AP2B1 NCEH1 NR1H2 APOC1 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system B2M TLR2 UBB MRC1 UBA52 UBC RPS27A WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis AWAT1 FAR1 FAR2 AWAT2 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System CHUK BTK S100A1 CD36 TIRAP F12 KLKB1 NFKB2 MYD88 RELA TICAM1 UNC93B1 LY96 TRAF3 CD14 TLR7 TLR3 HMGB1 NFKB1 IRAK4 NFKBIA TLR1 TLR10 TLR6 TLR5 TLR2 S100A9 S100A8 FGB FGA FGG IKBKB F2 TLR4 IKBKG SERPING1 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins FIP1L1 WDR48 STRN REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling CHUK TBK1 MAPKAPK2 TNF UBA52 STUB1 UBE2D1 TNFRSF1A RBCK1 SPPL2B USP2 SPPL2A UBB CLIP3 IKBKE TAX1BP1 OPTN UBC OTULIN RPS27A TRADD UBE2L3 CASP8 RACK1 TRAF2 UBE2D2 RNF31 MIB2 TNFAIP3 UBE2D3 SPATA2 OTUD7B IKBKB SHARPIN USP21 BIRC2 USP4 BIRC3 TRAF1 XIAP CYLD OTUD1 RIPK1 IKBKG FADD ULK1 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation AMT GLDC GCSH DLD OGDH DLST KGD4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 TP53 PSMD12 PSMD11 COP1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 IMP4 SNU13 SET RRP7A ANP32A PDCD11 ERI1 TNFSF13 GAR1 ELAVL1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 GEMIN2 PHAX NOL9 NOC4L SNRPD2 SNRPD1 NOL6 EXOSC10 SNRPD3 PRMT5 PES1 WDR77 RRP36 CLNS1A UTP6 UTP4 SNRPG RIOK3 GEMIN4 UTP3 GEMIN5 WDR18 SNRPE WDR12 GEMIN6 BYSL GEMIN7 SNRPF BOP1 TSR1 GEMIN8 SNRPB MPHOSPH6 RPP30 DDX20 SMN2 FBL SNUPN MTREX RPP38 DIMT1 FTSJ3 EBNA1BP2 DKC1 NHP2 RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 ZFP36 NOP14 RPP40 RCL1 NOP10 RBM28 PPIL2 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 SENP3 UTP18 C1D DDX21 BMS1 RPP14 DCAF13 KRR1 NCBP1 NCBP2 FIP1L1 XRN2 PQBP1 SRRT ZCRB1 SNRNP200 FUS ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 SKIC2 HNRNPA3 GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 DHX16 NOP56 NUP205 HNRNPA2B1 POM121 NUP188 WBP11 AAAS POM121C PPIE NUP42 PPIH NUP62 TPR PPIG NUP88 RAE1 DDX46 NUP214 DDX42 NDC1 RBM17 NUP210 FASTKD5 NUP155 TBRG4 SMG1 BUD31 SMG9 NUP153 NUP93 SMG7 SMG8 NUP50 RBM22 SMG5 DDX23 NUP35 SMG6 NUP54 PNRC2 SMNDC1 SAP18 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 SLIRP MTPAP CPSF2 TRMT61B CSTF2T WDR33 LRPPRC NUDT21 HNRNPL PCF11 CLP1 HNRNPM HNRNPK CSTF1 RPL4 PAPOLA RPL5 HNRNPF SYMPK RPL30 HNRNPD RPL3 RPL32 SF3B4 RPL31 SF3B5 RPL34 SF3B2 SF3B3 RPL10L SF3B6 RPL10A RPL8 SF3B1 RPL6 SF3A3 RPL7 SF3A1 SF3A2 XAB2 RPS15 PHF5A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 TXNL4A RPL36AL RPL36 CNOT6L SNRPN RPL35 CHERP RPL38 RPL37 RPS11 RPL39 PTBP1 RPS10 PLRG1 RPS13 SNRPA1 RPS12 RPS9 DNAJC8 RPL21 RPS7 PUF60 RPS8 SNRPB2 RPL23 ZNF473 RPS5 RPL22 PPIL1 RPS6 SNRNP40 RPSA RPL9P9 RPL24 RPL27 RPL26 PPIL3 RPL29 PPIL4 RPL28 SRRM2 TRNT1 RPS4Y2 AQR HSPB1 RPS4Y1 RPL39L CPSF4 WDR82 RPL41 CRNKL1 PDCD7 SNRNP35 SNRNP25 PRPF19 RNPC3 RPL3L RPS26 ZMAT5 ZRSR2 RPS25 SNRNP48 RPS28 RPS29 RPL27A HNRNPH1 RPS20 HNRNPH2 GRSF1 RPS21 RPS24 RPS23 RPLP1 CWC25 CWC27 RPLP0 EFTUD2 CWC22 RPS4X RPL7A PRPF6 RPLP2 PRPF8 CWC15 RPL13A RPS3A RBM5 PSMD8 RPL37A ZFP36L1 PSMD6 RPL10 PSMD7 RPL12 RBM27 PSMD2 RPL11 ZCCHC8 PSMD3 RPL36A ZCCHC7 PSMD1 RPS27L ELAC2 RBM26 RPS15A YTHDC1 ZC3H4 PABPN1 RPL14 ZC3H3 RPS3 YTHDC2 RPL13 TENT4B RPL15 PAPOLG RPS2 ZC3H18 PSMA5 RPL18 RBM7 PSMA6 RPL17 ZFC3H1 PSMA3 DXO PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 RAN PSMD11 RPL26L1 HSPA1A PSMD14 PSMD13 PSMA7 OSGEPL1 GTPBP3 TRMU PSMB6 SKIC8 PSMB7 YRDC PSMB4 MTO1 PSMB5 METTL14 REXO2 UBB PSMB2 METTL3 PSMB3 PNPT1 UBC SUPV3L1 PSMB1 WTAP RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HNRNPU NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 NOP58 THOC2 THOC5 IGF2BP1 THOC7 CDC40 TENT4A THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 HBS1L NT5C3B RBM8A SKIC3 POLDIP3 SRSF1 DCPS PRKCA U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 ACIN1 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 CSNK1D ADARB1 TNPO1 YWHAB SNW1 MAPK14 MAPK11 MAPKAPK2 CSNK1E TCERG1 SNRPC SRSF8 SNRPA HTATSF1 RBM25 PPP1R10 SNRNP70 PRPF40A TUT1 PPP1R8 XPO1 SRSF10 SRSF12 TGS1 RBM39 CNOT10 CNOT11 ADAR DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 YWHAZ QNG1 URM1 WDR4 PPP1CB THADA LAGE3 OSGEP THG1L ALKBH8 TYW1 LCMT2 TRMT44 PPP1CA TRDMT1 PUS3 TRMT10A TYW5 METTL1 NSUN2 EPRS1 TYW3 TYW2 TPRKB ADAT1 TRMT1 CDKAL1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 ADAT2 TRMT9B QTRT1 GON7 DUS2 PPP2R2A CTU2 QTRT2 CTU1 TNKS1BP1 TRMT5 TRMT6 TRMT13 TRMT11 TRMT61A GSPT2 GSPT1 DDX6 NCL LSM1 LSM5 LSM4 UPF3A LSM3 PATL1 EDC3 LSM2 UPF2 EDC4 LSM7 TUT7 LSM6 PABPC1 XRN1 TUT4 DCP1A DCP2 DCP1B TRA2B MTERF3 MTERF4 RBBP6 FASTKD2 TFB1M NSUN4 PAIP1 RPUSD4 CPSF7 RPUSD3 PAN2 TRUB2 PAN3 TRMT10C PRORP DDX5 RCC1L ETF1 NGRN MRM1 HSD17B10 MRM2 HNRNPC MRM3 RBMX EIF4E EIF4B EIF4G1 STEEP1 GPATCH1 PNN SF1 DHX8 PRKRIP1 CWF19L2 WDR70 DHX35 PRPF38A SMU1 NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A CACTIN LSM10 PRPF31 SLBP RBMX2 LSM11 SNIP1 IK PRP4K NUP107 LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 YJU2 CNOT4 LSM8 PPP2R1A PPWD1 USP39 CNOT6 SART1 CNOT7 TFIP11 SYF2 CNOT1 C9orf78 CNOT2 LUC7L3 CNOT3 NSRP1 WBP4 RNF113A MFAP1 TRMT112 CNOT8 RBM42 BUD13 FAM50A CNOT9 NUP160 NUP85 RPS27 SEC13 NUP133 APOBEC1 APOBEC3C APOBEC2 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B PPP2CA NUP43 TP53RK RANBP2 UPF1 NUP37 POP5 POP7 TSEN15 POP1 POP4 RTCB ZBTB8OS TSEN2 EIF4A2 TSEN54 EIF4A1 TSEN34 DDX1 C2orf49 RTRAF XPOT FAM98B NOP2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 PRKCD GTF2H5 YBX1 CDK7 ERCC3 ERCC2 MNAT1 AKT1 IGF2BP3 IGF2BP2 DDX41 ZNF830 DHX9 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway TNFRSF6B CHUK TNFSF18 FBXW11 TNFSF14 PSMA5 TNFSF15 PSMA6 TNFSF12 PSMA3 UBE2M PSMA4 EDARADD PSMA1 TNF EDAR PSMA2 UBA52 LTA PSMD12 LTB PSMD11 PSMD14 PSMD13 TNFRSF1B CUL1 TNFRSF1A TNFRSF11B TNFRSF11A PSMA7 PSMB6 TNFSF11 PSMB7 PSMB4 TRAF3 PSMB5 UBB PSMB2 CD27 TNFRSF13B PSMB3 TNFRSF13C UBC EDA2R PSMB1 TNFRSF12A RPS27A CD70 ADRM1 EDA SEM1 PSMC5 PSMC6 TNFSF6 PSMC3 PSMC4 TNFSF4 PSMC1 TNFSF9 PSMC2 TNFSF8 LTBR TNFSF13 CD40LG TNFRSF14 NFKB2 MAP3K14 RELB TNFRSF18 TRAF2 PSMD8 TNFRSF8 PSMD6 TNFRSF4 BIRC2 PSMD7 BIRC3 PSMD2 PSMD3 TNFRSF17 PSMD1 TNFRSF9 BTRC TNFSF13B SKP1 TNFRSF25 UBA3 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE ABCC6 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina PRKCB PRKCA CCNB1 LMNB1 CDK1 EMD CTDNEP1 LEMD3 CNEP1R1 LPIN1 LPIN2 LEMD2 LPIN3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion OSGEPL1 HSD17B10 GTPBP3 TRMU YRDC MTO1 TRMT61B TRMT10C PRORP TRIT1 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type MMAB SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants STAT3 HRAS PDGFRA SOS1 PIK3R2 PIK3CA PIK3R1 PIK3CB NRAS STAT1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX5 ALOX15 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling ITGA2B SPRED3 SPRED2 SPRED1 CALM1 FN1 KRAS PAPSS1 NF1 BCL2L11 ATG7 SRC DUSP6 DUSP7 PPP1CB YWHAB MARK3 MRAS NRAS RAP1A MAPK1 SHOC2 HRAS MAPK3 MAP2K1 MAP2K2 TENT4A KIAA1549 MPRIP BRAF TRIM24 AGTRAP AP3B1 SND1 ESRP1 DUSP16 AKAP9 PPP1CC KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 LMNA AGK QKI CLCN6 FAM131B AGGF1 CAMK2B CAMK2D CAMK2A CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 CSK DUSP10 VCL MAP3K11 DUSP8 DUSP9 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation IDS SDC1 HPSE GPC1 HSPG2 GPC3 IDUA GPC2 SDC4 SGSH SDC2 GPC5 SDC3 GPC4 GPC6 HPSE2 AGRN CTSL NAGLU DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant F9 F8 F10 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling PRKAR2B PRKACA PRKACG ADCY4 PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A GNAS ADCY9 PRKAR1B INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling STAT4 JAK1 STAT3 IL12RB2 CANX IL27RA IL12A EBI3 JAK2 IL6ST STAT1 TYK2 PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation FDX1 DBT GCSH NFU1 LIAS NDUFAB1 DLAT LIPT2 LIPT1 DLST TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD3 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism ADH1A MAPDA NT5C2 PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling DDOST APP LGALS3 AGER MAPK1 S100A12 S100B MAPK3 PRKCSH SAA1 CAPZA1 HMGB1 CAPZA2 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage GSDMD CASP3 CASP5 IL18 IL1B SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs HACD3 HACD2 HACD4 ELOVL1 ELOVL5 ELOVL4 ELOVL2 ACSL6 ACSL5 ELOVL3 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ELOVL6 ACSBG1 ACSL1 SLC27A3 ACSBG2 HACD1 TECR HSD17B3 HSD17B12 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes ME1 IDH1 NFE2L2 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PPIE CETN2 LIG1 USP7 ERCC6 XAB2 ACTL6A DDB2 COPS5 AQR ERCC8 PRPF19 UBE2N RUVBL1 NFRKB PARP1 PARP2 ACTR5 USP45 RAD23A CHD1L ACTR8 YY1 RAD23B INO80C INO80B INO80E INO80D XPA COPS7B COPS7A XPC TFPT MCRS1 INO80 COPS3 COPS6 ERCC4 ERCC1 ELL ERCC5 COPS8 UBA52 RNF111 UBB UBC RPS27A RBX1 TCEA1 PIAS3 UBE2I ACTB XRCC1 LIG3 CUL4A CCNH DDB1 POLR2A PIAS1 POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F SUMO1 POLR2G SUMO3 POLR2H SUMO2 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 UBE2V2 ISY1 GPS1 PCNA POLD3 POLD4 COPS4 COPS2 POLD1 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription EZH2 H2AX ASH2L JUN TEAD1 TEAD2 TEAD3 H3-3B RELA TEAD4 H3C8 FOS H2AJ YAP1 NFKB1 CTNNB1 H3C15 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 H2BC1 FOSB H2AB1 H2AC8 H2AC6 H2AC7 MYCN KMT2A KMT2C TCF7 NFKB2 H2AC19 H2AC14 H2BC12L MYC DPY30 H2BC26 H2BC21 WDR5 EP300 EED ATF3 H2BC17 EPAS1 H2BC12 H2BC13 H2BC14 H2BC15 HIF1A CREBBP IRF1 H2BC11 LEF1 WWTR1 H4C9 RBBP4 RBBP5 JUND RBBP7 NFE2L2 TCF7L2 H2AZ2 TCF7L1 H2AC20 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease POLR2I POLR2J POLR2K POLR2L FGFR2 SOS1 GTF2F1 GTF2F2 NCBP1 NCBP2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 PIK3R1 PIK3CA FGF10 NRAS GAB1 HRAS PLCG1 POLR2A POLR2B FRS2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GP5 F11 GP1BA F9 GP9 GP1BB GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling PRKAR2B PRKACA PRKACG GNAI3 ADCY4 PRKACB ADCY3 GPER1 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 PRKAR1A SRC GNAZ ITGB1 ITGA5 GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNAT3 GNAS GNB4 GNB3 GNB5 ADCY9 PRKAR1B SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGX PIGC PIGB DPM2 PIGA PIGM PIGL PIGG PIGF PIGH PIGO PIGN PIGP PIGZ PIGW PIGV PIGY SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 FGF9 FGF20 HRAS FGF23 FGF16 SOS1 FGF18 FGF1 FGF2 FGF4 NRAS NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 SGCE LAMA4 LAMA3 SNTG2 SGCD LAMC2 SGCA SGCB LAMB1 LAMC1 DMD SGCG VTN SNTA1 DTNA DTNB SGCZ SSPN SNTB1 SNTB2 AGRN ITGB5 PDGFB DDR1 UTRN TRAPPC4 NTN4 DDR2 TTR PDGFA TNC DRP2 CASK ITGAV DAG1 PRKCA HSPG2 SDC4 SDC2 SDC3 THBS1 TGFB1 FGF2 SDC1 ITGB1 ITGB3 ACTN1 ITGB4 NRXN1 ITGA2 ITGA6 LAMA5 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ATM ZNF420 AIFM2 BNIP3L BBC3 TP63 TP53AIP1 BAX PRELID1 TP53 STEAP3 CREBBP TP53INP1 PRELID3A PPP1R13B TP53BP2 BID TP73 TRIAP1 PMAIP1 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants FLT3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 PPP2CA PPP2CB PPP2R1B PPP2R1A PPP2R2A UBA52 CDK7 CUL1 MNAT1 RBL2 RBL1 UBB UBC RPS27A CDKN1C RB1 CDKN2D PTK6 CDKN1A CDKN2B CDKN1B CKS1B CDKN2C CCND3 CDKN2A CCND2 CCND1 JAK2 E2F1 E2F2 ABL1 E2F3 E2F4 SKP2 LYN E2F5 PPP2R3B CDK6 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 SKP1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA AURKA PHLDA1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome RB1 ZCRB1 VHL DDX5 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism ACER2 ACER1 ALDH3B1 ACER3 PLPP3 PLPP2 PLPP1 ALDH3B2 SGPP2 SGPL1 SGPP1 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm CTNNB1 NOTO TCF7 FOXA1 FOXA2 TEAD2 LEF1 SHH FOXH1 TEAD4 SMAD2 SMAD3 YAP1 TBXT ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria YWHAG YWHAZ PPP3CC YWHAE SFN YWHAB BID AKT2 YWHAH BCL2 YWHAQ AKT3 BAD AKT1 PPP3R1 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly MTTP APOB PRKACA A2M PRKACG ABCA1 APOC4 PRKACB APOA1 APOE APOC3 APOA2 APOA4 APOC2 APOC1 P4HB ZDHHC8 SAR1B SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 GZMB JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 MAML2 MAML1 NEURL1 MDK FCER2 MAMLD1 UBB PSENEN PSEN2 PSEN1 UBC APH1A HES1 NCSTN RPS27A APH1B HES5 CNTN1 NOTCH2 EP300 RBPJ MIB2 NOTCH2NLA NOTCH2NLC NOTCH2NLB SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBA52 TSG101 NMT2 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 UBB VPS28 UBC RPS27A REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome RB1 ZCRB1 VHL DDX5 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t PGM1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity TNRC6A TNRC6B CCND3 CCND2 CCND1 CBFB CDK6 RUNX1 MOV10 AGO3 SRC AGO4 PTPN11 AGO1 AGO2 PML TNRC6C PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 FGF9 FGF20 FGF23 FGF16 PLCG1 FGF18 FGF1 FGF2 FGF4 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis PMVK FDFT1 FDPS IDI2 ACAT2 PLPP6 SQLE GGPS1 HMGCS1 LSS MVD IDI1 MVK DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 PROS1 PROC F5 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 SLC27A4 LCN15 LCN12 APOD SLC27A6 LCN9 LCN1 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f MPDU1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g ALG12 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters MTERF1 TFAM POLRMT TFB2M CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress EIF2S3 EIF2AK1 YME1L1 EIF2S2 EIF2S1 STOML2 OMA1 PHB2 DELE1 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNAR1 FURIN CCNC GPC1 TYK2 GPC3 JAK1 GPC2 GPC5 GPC4 STAT2 GPC6 MED9 MAP1B AGRN CDK19 MED16 MED15 MED17 MED12 MED14 IFNB1 MED13 MED10 CLEC4M MED27 MED26 HSPA8 MED23 MED25 MED24 PPP1CC MED20 CDK8 IRF3 SEC11A SEC11C EGFR KPNB1 LY96 EIF2AK2 ISG15 XPO1 CD209 EP300 TLR6 TLR2 SPCS3 SPCS2 SPCS1 MED1 H2BC15 CREBBP HSP90AA1 OAS2 TLR4 UBE2L6 HERC5 UBA52 ELOB BECN1 ELOC UBB CD14 MED8 UBC MED4 MED6 RPS27A MED7 RBX1 PPP1CB MED30 PPP1CA MED31 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 MAVS IFNA10 MED19 RIGI MED18 MED11 HSPG2 MED29 CX3CR1 RAB5B MED28 RAB5C MED22 IGF1R MED21 NCL SDC4 SDC2 RAB5A SDC3 TLR7 TLR3 HSP90AB1 CSNK2A1 CSNK2A2 CUL5 CSNK2B SDC1 MED13L ARIH1 BCAP31 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide CA1 CA2 HBB CA4 SLC4A1 RHAG AQP1 HBA2 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage ASCC2 ASCC3 ALKBH3 ASCC1 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation MMUT MMAA NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression SAP30 H2AX SUDS3 DNMT3B DNMT1 SAP30L H3-3B TBP SAP18 H3C8 H2AJ H3C15 HDAC1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CCNH MBD2 H2AB1 POLR2E POLR2F H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 SUV39H1 H2AC19 H2AC14 H2BC12L SIN3B SMARCA5 SIN3A H2BC26 H2BC21 TTF1 SAP130 UBTF SAP30BP H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 BAZ2A POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A SIRT1 RRP8 H4C9 H2AZ2 ARID4B H2AC20 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules SLC27A1 SLC35C1 SLC27A4 SLC33A1 SLC27A6 LCN9 ARL2 SLC35A3 LCN1 SLC25A5 SLC25A4 SLC29A3 SLC25A6 SLC35D2 SLC28A2 SLC29A1 SLC35A2 SLC35A1 SLC29A2 SLC28A3 SLC5A6 PDZD11 SLC35D1 SLC35B4 ARL2BP LCN15 LCN12 APOD SLC35B3 SLC35B2 SLC29A4 SLC28A1 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 CHST10 RXYLT1 FKTN SLC35A4 CRPPA FKRP B4GAT1 LARGE1 LARGE2 SLC35A1 DAG1 POMGNT1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse CD4 HLA-DRB3 TRBV12-3 HLA-DRB1 TRBV7-9 CD3G CD3E CD3D LCK TRAV19 TRAV29DV5 HLA-DQA2 PTPN22 HLA-DRB5 HLA-DRA HLA-DPA1 TRAV8-4 HLA-DRB4 HLA-DPB1 ZAP70 TRAC TRBC1 HLA-DQB2 HLA-DQB1 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway CASP8 RELA MALT1 PYCARD IL1B NFKB1 G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase CDK2 CCNA2 CCNA1 E2F1 E2F3 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding CCT6A GNAQ GNG10 GNG3 PDCL GNG2 GNG5 GNG4 GNG7 GNG8 CCT3 CCT2 CSNK2A1 CSNK2A2 CSNK2B TCP1 GNA14 GNGT1 GNA15 GNA11 GNGT2 CCT8 CCT7 GNG12 CCT5 GNG11 CCT6B CCT4 GNG13 GNB2 GNB1 RGS11 GNB4 RGS9 GNB3 RGS6 GNB5 RGS7 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair HGS NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 PGR ADAM17 NRG2 NRG3 NRG4 SPARC PSENEN PSEN2 MXD4 SRC PSEN1 APH1A NRG1 YAP1 CSN2 NCSTN APH1B STMN1 STAT5A ADAP1 TAB2 CXCL12 WWOX EREG BTC HBEGF APOE GFAP NCOR1 S100B ESR1 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 CCNB1 NUP93 NUP50 NUP35 NUP54 NUP160 CDK1 CCNB2 NUP85 NUP37 NEK9 NEK6 NEK7 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement C6 C7 C9 C5 C8B C8A C8G CLU EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells EPHA10 EFNA5 EFNA4 EFNB2 AP2A1 EFNB1 EFNB3 EPHB2 ADAM10 AP2A2 VAV3 EFNA1 EPHA1 EPHA2 EFNA3 EFNA2 RAC1 AP2M1 MMP9 VAV2 PSENEN PSEN2 CLTCL1 PSEN1 APH1A NCSTN APH1B AP2S1 CLTC DNM1 CLTA LYN AP2B1 YES1 TIAM1 EPHB6 CLTB EPHB1 FYN EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 EPHA3 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events POM121C NUP42 NUP62 NUP43 EZH2 H2BC18 TPR NUP88 RAE1 DYNC1I1 NUP214 RANBP2 NDC1 NUP210 DYNC1H1 NUP155 TRIM28 NUP153 NUP93 NUP50 NUP35 NUP54 H3C8 NUP37 NFKB1 H3C15 ELK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 DAXX H2BC1 NUP107 H2AC8 H2AC6 H2AC7 DYNC1LI1 DYNC1LI2 H2AC17 EGFR H2AC12 NCOR2 H2AC1 HDAC3 NUP160 H2AC19 H2AC25 H2AC14 H2AC21 NUP85 GPS2 H2BC26 H2BC21 EED TBL1X H2BC17 ITGB1 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 DYNLL1 H2BC11 CBX1 DYNLL2 NCOR1 TBL1XR1 H4C9 RBBP4 RBBP7 DYNC1I2 NUP205 POM121 H2AC20 NUP188 AAAS PML GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation SLC35D2 UGT1A3 UGT1A10 ABHD10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 SLC35D1 UGT3A2 UGT3A1 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGDH UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGP2 UGT1A6 UXS1 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants KIT GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle PPFIA3 PPFIA2 SLC38A2 SNAP25 ARL6IP5 SYT1 UNC13B VAMP2 CPLX1 STX1A GLS GLS2 TSPOAP1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC17A7 RAB3A SLC1A7 RIMS1 PPFIA1 PPFIA4 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 GGCX F9 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH SPRTN NPLOC4 VCP PCNA UBA52 POLH RFC5 UFD1 RFC3 RPA1 RPA2 RFC4 UBB RFC1 RFC2 UBC RPA3 RPS27A RCHY1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FCSK FPGT FUOM GFUS FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation CD3G IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK SYK IGHG3 IGHG4 IGHG1 IGHG2 FCGR3A LYN FGR YES1 FCGR1A FCGR2A PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism KYAT1 ASRGL1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PAH PCBD1 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling GAB1 RAB4B RAB4A MET HGF CRK ARF6 GGA3 CRKL LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling MTTP APOB P4HB APOF LPA CETP MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation GRSF1 FASTKD2 REXO2 SLIRP PNPT1 FASTKD5 SUPV3L1 TBRG4 LRPPRC BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins ALOX5 CYP2E1 CYP3A4 CYP2C9 EPHX2 CYP2C8 CYP2D6 CYP1A2 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation QARS1 PPA1 TARS1 AARS1 HARS1 RARS1 FARSA FARSB MARS1 YARS1 NARS1 CARS1 VARS1 RARS2 AARS2 DARS1 MARS2 WARS1 PARS2 LARS1 DARS2 SARS1 HARS2 YARS2 EEF1E1 FARS2 KARS1 WARS2 GARS1 IARS1 LARS2 SARS2 PPA2 NARS2 AIMP1 TARS2 IARS2 AIMP2 VARS2 EPRS1 CARS2 EARS2 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation SOD1 SNRPA1 MTAP CFL1 ANXA2 GSTO1 SOD2 TALDO1 LMNB1 GSTA2 IFNG CA1 MSN IL10 PSME2 HNRNPF HSPA9 TCP1 PITPNA RALA SERPINB2 PAK2 AIP MIF RPLP0 RAP1B LCP1 BOLA2B CNN2 HNRNPDL STAT4 ARF1 CDC42 PDCD4 HNRNPA2B1 PPIA CAPZA1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors PITX2 TFAP2A TFAP2C CITED2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 AURKA CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 TPX2 NINL OFD1 CPAP TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HMMR HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression EZH2 H2AX PRKAG1 PRKAG2 ASH2L CUL3 MAGT1 PRKAG3 TEAD1 TEAD2 JAK1 TEAD3 H3-3B TEAD4 H3C8 FOS PDCD1LG2 H2AJ B3GNT3 YAP1 DERL3 DERL1 DERL2 CTNNB1 H3C15 OS9 SPOP BRD4 SUZ12 CCND1 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 FOSB CDK4 TUSC3 H2AB1 NEK2 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 GSK3B DPY30 H2BC26 H2BC21 WDR5 YWHAG EP300 EED H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 CREBBP DAD1 IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 ERLEC1 PSMD8 RBBP4 RBBP5 PSMD6 PSMD7 PSMD2 NFE2L2 RBBP7 PSMD3 TCF7L2 PSMD1 H2AZ2 TCF7L1 BTRC SKP1 TNRC6C PDCD1 PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 JUN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L MYC PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B ATF3 RPN2 EPAS1 RPN1 HIF1A WWTR1 H4C9 JUND ERLIN1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF COL9A2 COL6A5 FURIN RASA1 PDGFRA SRC PDGFRB PDGFB CRKL NRAS STAT1 STAT3 HRAS PLCG1 PTPN12 RAPGEF1 SOS1 CRK SPP1 PDGFD THBS1 PLG PIK3CB THBS4 BCAR1 THBS3 STAT5A THBS2 STAT5B PIK3R2 PLAT PIK3CA PIK3R1 NCK2 COL4A2 NCK1 GRB7 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 COL9A1 COL6A3 STAT6 COL4A5 PTPN11 COL9A3 COL6A6 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation FGFR4 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling PPP2CA PPP2CB PPP2R1A UBA52 UBB FGF1 FGF2 UBC FGF3 FGF4 RPS27A CBL FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 MKNK1 FGF18 SPRY2 FGF10 MAPK1 MAPK3 FRS2 BRAF PTPN11 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors IAPP RAMP2 CALCA CALCR RAMP3 CALCB ADM2 CALCRL ADM RAMP1 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling ITGA2B SOS1 CRK FN1 SYK PTK2 RASGRP2 SRC AKT1 BCAR1 PDPK1 ITGB3 RAP1B SHC1 FGB FGA RAP1A VWF FGG APBB1IP RAPGEF3 CSK PTPN1 TLN1 RAPGEF4 RASGRP1 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 NEIL3 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l ALG9 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis CD3G IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 PRKACG IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK AHCYL1 ADCY9 PRKAR1B PRKAR2B PLCG2 PRKACA SYK ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 PRKAR2A ADCY6 ITPR1 ADCY5 ITPR2 ITPR3 IGHG3 IGHG4 PRKAR1A IGHG1 IGHG2 IL10 FCGR3A LYN FGR YES1 FCGR1A FCGR2A PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO SUMO2 UBE2I RWDD3 UBA2 SAE1 SENP5 SENP2 SENP1 SUMO1 SUMO3 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins UBE2I SUMO1 RANGAP1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events FURIN VCP CHMP2B CHMP2A GPC1 BECN1 UVRAG HSPG2 MAP1LC3B GPC3 ISCU GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 ZCRB1 NRP1 PIK3R4 AGRN TMPRSS2 SDC1 ACE2 RB1 HAVCR1 PIK3C3 VHL DDX5 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 CTSL P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling RAC1 LINGO1 MAG OMG RTN4 VAV1 MAPK8 NGFR SQSTM1 TIAM1 SORCS3 NGF SOS1 ADAM17 RASGRF2 HDAC3 ARHGEF18 SMPD2 RHOA ARHGEF10L BAD AKAP13 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 BEX3 IRAK1 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 HDAC2 ECT2 PREX1 ARHGDIA MCF2L NET1 IKBKB ABR TRAF6 ITGB3BP ARHGEF16 ARHGEF40 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF5 TIAM2 OBSCN YWHAE ARHGEF4 ARHGEF26 ARHGEF7 UBA52 NGEF ARHGEF6 FGD1 FGD2 KALRN GNA13 FGD3 PRKCI FGD4 RIPK2 MYD88 BCL2L11 ARHGEF33 RELA ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 UBB AATF PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A PRDM4 APH1B NFKB1 NFKBIA HDAC1 CASP3 VAV3 CASP2 VAV2 SOS2 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling STAT5A IL15 STAT5B GAB2 GRB2 SOS1 IL2RG JAK3 SHC1 JAK1 STAT3 SOS2 IL15RA IL2RB TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes TNRC6A PRKAG1 TNRC6B PRKAG2 YWHAE RPTOR CYCS SFN PRKAG3 GLS TSC2 TSC1 COX7A2L RRAGA RRAGC PRDX2 RRAGB RRAGD PRDX1 YWHAH SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 YWHAZ YWHAB COXFA4 COX7A2 COX7A1 COX7B COX7C GPI COX8A COX8C COX5B COX5A TP53 COX6C COX4I1 COX4I2 PTEN COX6A1 AKT2 COX6A2 AKT3 AKT1 G6PD PRKAB2 COX6B2 MLST8 GPX2 PRKAB1 COX6B1 YWHAG HIGD1C RRM2B MT-CO1 TP63 TIGAR GLS2 PRKAA1 PRKAA2 SCO2 SESN3 DDIT4 YWHAQ MOV10 SESN2 MT-CO2 TXN AGO3 MT-CO3 AGO4 TXNRD1 AGO1 MTOR AGO2 TNRC6C CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL TUBGCP2 TUBGCP5 TUBGCP6 OFD1 TUBGCP3 CPAP TUBGCP4 TUBG2 MZT2B MZT2A NME7 MZT1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CDK11A CDK11B CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BCL7A PBRM1 BCL7C DPF1 BCL7B DPF2 DPF3 SMARCB1 SS18 SS18L1 ARID1A ARID1B SMARCD3 SMARCC1 SMARCC2 ARID2 BCL11A BRD7 BICRAL BICRA BRD9 SMARCD1 SMARCD2 BCL11B PHF10 SMARCA2 ACTB SMARCA4 ACTL6B ACTL6A SMARCE1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle PPFIA3 PPFIA2 LIN7A LIN7C SNAP25 LIN7B SYT1 UNC13B VAMP2 CPLX1 STX1A TSPOAP1 SLC18A2 SYN3 SYN2 SYN1 RAB3A CASK RIMS1 APBA1 PPFIA1 PPFIA4 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB2 KCNMB3 KCNMB1 KCNMB4 KCNMA1 KCNN1 KCNN3 KCNN2 KCNN4 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses SYT10 RTN3 DBNL NTRK3 SYT2 SYT1 STX1A GRIN2B SHARPIN EPB41L3 CASK GRIA1 LIN7A LIN7C LIN7B EPB41L1 HOMER3 GRIA3 EPB41 GRIA4 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 PTPRS PTPRF SIPA1L1 GRIN2C DLGAP1 DLGAP3 DLGAP2 GRIN2D DLG1 DLGAP4 GRIN1 DLG3 BEGAIN GRIN2A DLG4 DLG2 APBA3 APBA2 LRRC4B SYT7 PTPRD LRFN3 PPFIA1 LRFN2 PPFIA4 LRFN4 PPFIA3 LRFN1 GRM1 LRRTM3 PPFIA2 GRM5 LRRTM4 LRRTM1 LRRTM2 FLOT1 SYT9 IL1RAPL2 IL1RAPL1 FLOT2 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 SLITRK2 SLITRK1 SLITRK4 SLITRK6 PDLIM5 NLGN4Y NLGN4X SYT12 SLITRK3 SLITRK5 APBA1 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants ALK RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle RHOBTB1 TRA2B MYO6 STK38 RBBP6 RNF20 CUL3 SPEN CPSF7 TXNL1 COPS4 COPS2 PDE5A VIM CCT7 HNRNPC RBMX DBN1 SRRM1 ROCK1 CCT2 ROCK2 GPS1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis CD3G PLD4 RAC1 VAV1 PAK1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 PLD2 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 PRKCE IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 HSP90AA1 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 PLD1 IGKV5-2 IGKV1-5 IGLC6 LIMK1 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 AHCYL1 BTK PLA2G6 PLCG2 MYO5A ARPC1B CFL1 ARPC1A VAV3 WASL PTK2 SYK PRKCD WAS VAV2 NF2 ITPR1 ITPR2 ITPR3 IGHG3 IGHG4 IGHG1 HSP90AB1 IGHG2 PLPP5 PLPP4 PLD3 MYH9 ACTG1 MYO9B NCKIPSD PIK3R2 ARPC4 PIK3R1 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 FCGR1A WASF3 MYO10 FCGR2A MYO1C LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy CHMP2B CHMP2A UBA52 PCNT HBB UBB UBC RPS27A IFT88 ARL13B TSG101 MVB12B MVB12A CETN1 PARK7 VPS37C RNASE1 CHMP4C HDAC6 VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A PLIN2 CHMP6 CFTR UBAP1 CHMP7 PLIN3 VPS28 HSPA8 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions CNTN2 NRP2 NRCAM DLG1 DLG3 DLG4 ANK1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts AKR1C3 CH25H OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 ABCB11 ACOT8 HSD17B4 SLC27A2 OSBP CYP8B1 CYP46A1 CYP39A1 NCOA1 BAAT NCOA2 ACOX2 HSD3B7 OSBPL1A SLC27A5 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP7A1 CYP27A1 AMACR RXRA DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels KCND2 KCND3 KCNIP1 KCNIP2 KCNIP4 KCNIP3 KCND1 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis ST3GAL2 B4GALT6 ST3GAL3 ST6GALNAC5 UGCG UGT8 B4GALT5 B3GNT5 B4GALNT1 ST6GALNAC6 B3GALNT1 FUT2 FUT1 ST8SIA5 GAL3ST1 ST3GAL5 A4GALT CERK B3GALT4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA7 CHRNA6 CHRNA9 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis KPNA1 H1-1 SFN H1-0 H1-3 H1-2 H1-5 H1-4 CASP7 DBNL GAS2 MAPT ADD1 PLEC CDH1 CTNNB1 MAPK8 BMX BBC3 SPTAN1 PAK2 CDKN2A YWHAB E2F1 APC MAPK1 STAT3 TFDP1 MAPK3 TP73 TFDP2 BCL2 BCL2L1 GSN PRKCQ KPNB1 BID LY96 BAD CASP9 TRADD HMGB1 CASP8 YWHAG DFFB DFFA TNFSF10 HMGB2 TP63 TRAF2 DYNLL1 DYNLL2 APIP PSMD8 TLR4 PSMD6 BIRC2 PSMD7 PSMD2 YWHAQ PSMD3 XIAP PSMD1 RIPK1 FADD BAK1 PPP3R1 GSDMD TNFRSF10B GZMB TNFRSF10A NMT1 PSMA5 PSMA6 PSMA3 YWHAE PSMA4 PSMA1 FAS CYCS PSMA2 UBA52 FASLG BAX PSMD12 C1QBP PSMD11 GSDME PSMD14 PSMD13 LMNB1 PSMA7 UNC5A BCL2L11 DAPK1 TICAM2 MAGED1 PSMB6 UNC5B TICAM1 TP53BP2 PSMB7 DAPK2 PSMB4 DAPK3 YWHAH PSMB5 UBB CD14 APPL1 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 YWHAZ PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DSP TJP1 OCLN CASP3 DSG1 PKP1 SATB1 DSG2 DSG3 TJP2 PMAIP1 CLSPN PTK2 TP53 PRKCD OMA1 STK24 AVEN CASP6 DIABLO STK26 OPA1 CARD8 DNM1L UACA ACIN1 PPP1R13B AKT2 AKT3 AKT1 ROCK1 APAF1 ARHGAP10 PPP3CC BMF DCC VIM BCAP31 FNTA SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer TGFA SOS1 EREG UBA52 PIK3R1 BTC PIK3CA EPGN SHC1 HBEGF EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF UBB AREG UBC RPS27A CBL SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events PPP2CA PPP2CB PPP3CC PPP2R1B PRKAR2B PPP2R1A CALM1 PRKACA PRKACG PPP1R1B PPP2R5D PRKACB PPP1CA CDK5 PRKAR2A PDE4A PDE4D PDE4C PPP3CA PRKAR1A PPP3CB PPP3R1 PRKAR1B FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 MASP1 FCN1 FCN2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism MCCC2 PCCB ACACA MCCC1 BTD HLCS PC PCCA INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ZP1 SPAM1 ADAM21 ZP3 ADAM20 ZP2 OVGP1 ZP4 ADAM30 ADAM2 B4GALT1 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) CTNNB1 DOCK1 CBLL1 ELMO1 ARHGEF4 UBA52 CTNNA1 RAC1 VAV2 FARP2 JUP CDC42 CDH11 TIAM1 UBB CTSS SRC UBC CTNND1 CTSL CTSB RPS27A CDH1 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) ALOX5 PTGS2 CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP1A2 LTC4S CYP1A1 CYP2E1 ALOX15 GSTM4 EPHX2 ALOX12 HPGD LTA4H PTGR1 ALOX5AP LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis B3GALT5 ST3GAL3 ST6GALNAC6 B3GALT2 B3GALT1 FUT2 FUT4 FUT3 FUT6 FUT5 FUT7 FUT9 ST3GAL6 B4GALNT2 B3GALT4 ST3GAL4 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SMARCB1 SS18 SS18L1 ARID1A ARID1B SMARCD3 SMARCC1 SMARCC2 BCL11A SMARCD1 SMARCD2 BCL11B PHF10 SMARCA2 ACTB SMARCA4 ACTL6B ACTL6A SMARCE1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways CHUK ITCH APP RIPK2 RELA PANX1 NFKB1 NOD1 NOD2 IRAK2 TNFAIP3 BCL2 CYLD MAPK14 BCL2L1 MAPK12 MAPK13 MAPK11 MEFV UBE2V1 CASP2 NFKB2 PYCARD HSP90AB1 CASP9 CARD9 AAMP CASP8 HMOX1 UBE2N NLRP1 TAB3 CASP4 TAB2 TAB1 IRAK1 CASP1 NLRP3 PSTPIP1 NLRC4 AIM2 IKBKB BIRC2 P2RX7 TRAF6 BIRC3 TXNIP TXN SUGT1 IKBKG MAP3K7 MAP2K6 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 TNPO1 ANAPC2 XPO1 ANKLE2 PTTG1 EMD LEMD3 RCC1 LMNB1 SPAST CC2D1B SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 TUBB6 TUBB3 TUBB1 TUBA4B PPP2R2A TUBA4A TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 NUP62 BANF1 NDC1 NUP155 NUP93 NUP35 NUP54 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 KPNB1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 LBR KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 CHMP4A BIRC5 PSMD8 KIF2C CHMP6 KIF2B CHMP7 PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CHMP2B CLASP1 PSMA4 DYNC1I1 CHMP2A PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 RAN NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2I SUMO1 VPS4A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs MYH9 PAK1 MYLK CALM1 MYL12B PPP1CB PAK3 PPP1R12A PAK2 PPP1R12B MYH11 RAC1 FLNA NF2 LIMK1 CDC42 MYH14 MYH10 CTTN MYL6 MYL9 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle HGS RAB9B CCNE1 CUL3 PLIN3 VHL LRRC41 RHOBTB3 RAB9A PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF9 FGF20 FGF23 FGF22 PLCG1 FGF1 FGF2 FGF10 FGF3 FGF4 FGF6 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL LCLAT1 HADHB PLA2G6 HADHA TAFAZZIN PLA2G4A ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes POM121C NUP42 NUP62 FURIN TPR NUP88 RAE1 KPNA1 NUP214 SFN NDC1 NUP210 UBE2E1 NUP155 NUP153 NUP93 NUP50 JAK1 NUP35 NUP54 CDK1 EIF4E EIF4G1 STAT1 HSPA1B STAT3 MAPK3 PLCG1 KPNA7 KPNA4 KPNA5 NUP107 EIF4G3 KPNA2 HSPA8 EIF4G2 KPNA3 EIF4E3 PPP2R1B FANCC PPP2R1A IRF3 NPM1 NUP160 IFIT1 KPNB1 NUP85 FAAP100 EIF2AK2 GBP5 ISG15 PDE12 UBE2N CASP1 SEC13 NUP133 PPP2R5A RNASEL FAAP24 FAAP20 PGGT1B FLNB HSPA1L ILF2 DNAJC3 OAS2 IKBKB FANCM GBP2 FANCL GBP4 FANCA HSPA2 FANCB FANCE IKBKG FANCG FANCF UBE2L6 CHUK PPP2CA HERC5 PPP2CB NUP43 ADAR EIF2S3 OASL GBP1 EIF2S2 OAS1 EIF2S1 OAS3 RANBP2 UBA52 EIF4E2 ABCE1 BECN1 HSPA1A GBP3 SNCA MX2 MX1 CENPX UBB UBC CENPS RPS27A NUP37 EIF4A2 EIF4A1 EIF4A3 USP18 UBE2I ACTB NEDD4 SUMO1 TRIM25 PTPN2 DUS2 MAVS TP53 RIGI FLNA PIN1 PPM1B SPHK1 UBA7 ACTG1 PRKRA PIM1 TARBP2 NCK1 ILF3 DHX9 ARIH1 NUP205 POM121 NUP188 FNTA FNTB MAP2K6 AAAS CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism GATM CKMT2 SLC6A8 CKMT1B GAMT CKM SLC6A12 SLC6A11 CKB SLC6A7 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling GATA3 H2AX MMP9 H3-3B H3C8 FOS H2AJ SRC FKBP5 H3C15 NOS3 TGFA ELK1 EREG CDKN1B UHMK1 BTC EPGN CCND1 HBEGF H2BC9 H2BC8 H2BC5 NRAS H2BC3 MAPK1 HRAS H2BC1 MAPK3 FOSB EGF BCL2 AREG H2AB1 KPNA2 SMC3 H2AC8 H2AC6 H2AC7 EGFR GPAM ATF2 SP1 PRKCZ RAD21 STAG1 XPO1 H2BC26 H2BC21 STAG2 NRIP1 EP300 PDPK1 H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 PIK3CA CREBBP SMC1A H2BC11 HSP90AA1 CARM1 YY1 H2AZ2 TNRC6C TNRC6A CALM1 TNRC6B CCNT1 JUN FOXO3 MYB CBFB TBP RUNX1 GTF2A1 GTF2A2 CITED1 S1PR3 PRMT1 CDK9 HDAC1 GNGT1 KCTD6 GNGT2 ESR1 CAV1 POLR2A POLR2B GNAT3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I ESR2 POLR2J PGR POLR2K POLR2L GTF2F1 PTK2 KAT5 GTF2F2 GNAI3 AXIN1 KAT2B IGF1R ZDHHC7 GNG10 GNG3 H2AC19 ZDHHC21 GNAI1 H2AC14 PPID GNG2 H2BC12L CAV2 GNAI2 AKT2 MMP7 GNG5 MYC GNG4 AKT3 GNG7 PPP5C GNG8 AKT1 HSP90AB1 STRN SPHK1 CXCL12 MMP3 PIK3R3 PIK3R2 SRF FOXA1 PIK3R1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD GNG12 NCOA3 H4C9 GNG11 NR5A2 GNG13 TFF3 JUND TFF1 GNB2 KANK1 CXXC5 MOV10 GNB1 KDM4B AGO3 PTGES3 AGO4 GNB4 USF2 H2AC20 GNB3 USF1 AGO1 GNB5 ZNF217 AGO2 MMP2 EBAG9 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB NFKBIA IRAK1 UBA52 NGFR SQSTM1 PRKCI RIPK2 MYD88 RELA IKBKB UBB TRAF6 UBC NGF RPS27A NFKB1 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs CTNNB1 CDC42 CALM1 IQGAP1 CLIP1 MEN1 CTNNA1 IQGAP2 IQGAP3 RAC1 CDH1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB PPP2R2D PPP2R1B PPP2R1A ARPP19 CDK1 ENSA CCNB1 MASTL ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria TFDP1 TFDP2 PMAIP1 TP53 E2F1 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants KIT TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A KDM5B CDKN1A MYC TFAP2C PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors CHRNA6 CHRND CHRNG CHRNE CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly CALM2 CASP4 CALM1 SERPINB1 CALM3 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD MMACHC MMADHC HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism HS3ST6 HS3ST4 HS6ST2 HS3ST1 HS6ST3 HS3ST2 NDST2 NDST1 NDST4 NDST3 GLCE HPSE EXTL2 GPC1 HSPG2 GPC3 HS3ST3A1 IDUA GPC2 SDC4 SGSH SDC2 HS2ST1 GPC5 SDC3 GPC4 SLC35D2 EXTL3 GPC6 AGRN HS3ST3B1 NAGLU IDS EXT1 EXT2 SDC1 HPSE2 CTSL HS6ST1 HS3ST5 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 CYCS COX7A2L PTK6 FABP1 STAT3 COXFA4 ALB ABCC1 COX7A2 COX7A1 COX7B HMOX2 COX7C RXRA COX8A COX8C PPARA COX5B COX5A COX6C NCOR2 HDAC3 COX4I1 SMARCD3 COX4I2 CHD9 COX6A1 HBB COX6A2 BACH1 SIN3A HELZ2 COX6B2 TGS1 COX6B1 HMOX1 TBL1X HIGD1C MT-CO1 NLRP3 NCOA1 MED1 NCOA2 CREBBP NCOA6 STAP2 HBA2 NCOR1 TBL1XR1 CARM1 MAFK TXNIP NFE2L2 MT-CO2 BLVRB MT-CO3 BLVRA HM13 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis CASP8 RIPK3 MLKL TRAF2 RIPK1 FADD TRADD PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling CBX6 PHC2 EZH2 PHC1 CBX4 CBX2 PHC3 RAC1 MDM2 BMI1 RING1 VAV1 SRC PIP5K1A RNF2 PIP5K1B TGFA MET RICTOR SUZ12 NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 CD86 EGF FRS2 CD80 AREG CD19 THEM4 NRG2 NRG3 NRG4 ATF2 HDAC3 HGF PRR5 GSK3B PIK3CD PIK3CB PIK3CG PIP5K1C MLST8 EED PDPK1 EGR1 IRAK1 PIK3CA LCK CHD4 RBBP4 CHD3 FYN TRAF6 RBBP7 RHOG PTPN11 MTOR TNRC6C INS TNRC6A SALL4 MTA2 TNRC6B REST JUN FOXO3 PIP4K2A PIP4K2B PDGFRA PDGFB KIT IL33 RAC2 HDAC1 IL1RL1 SNAI2 TP53 KDM1A SNAI1 PREX2 TRIM27 USP13 TNKS TNKS2 WWP2 RNF146 FRK OTUD3 RCOR1 RPTOR TSC2 RRAGA RRAGC USP7 RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CDKN1A EREG CDKN1B BTC EPGN HBEGF FLT3 PPP2R1B PPP2R1A EGFR KLB IRS1 IRS2 MBD3 FGF1 BAD FGF2 CASP9 FGF3 NRG1 FGF4 FGF6 FGF7 FGF9 FGF20 GATAD2B FGF23 PPP2R5E GATAD2A FGF22 GAB2 FGF16 FGF19 FGF18 PPP2R5B HDAC5 FGFR4 PPP2R5A FGF10 PPP2R5D HDAC2 PPP2R5C HDAC7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 PML PPP2CA CHUK PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYD88 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PDGFRB ADRM1 TRAT1 SEM1 IRAK4 NTRK3 PIK3AP1 PSMC5 IER3 SGK1 PSMC6 PHLPP2 PSMC3 PHLPP1 PSMC4 FLT3LG PSMC1 ATN1 FOXO6 PSMC2 MAF1 FOXO4 FOXO1 RPS6KB2 MTA1 MTA3 ESR1 NEDD4 GSK3A ESR2 PPARG NR4A1 NR2E1 MECOM PTEN AKT2 AKT3 AKT1 ERBB2 STRN CSNK2A1 CSNK2A2 CSNK2B TRIB3 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR MOV10 AGO3 AGO4 AGO1 MKRN1 AGO2 CD28 CBX8 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation CD79B DAPP1 CD79A IGHM BLNK IGHD VAV1 SH3KBP1 IGHV3-23 IGLV NRAS IGLV2-8 IGKV1-16 IGKV1-17 HRAS IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 CD19 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 PIK3CD IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CD22 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 PSMD8 IKBKB IGKV3D-20 PSMD6 FYN PSMD7 PSMD2 PSMD3 PPP3CA IGLV3-19 PSMD1 PPP3CB IGKV2-30 PPIA IKBKG IGHV2-70 BTRC RASGRP1 IGHV2-5 MAP3K7 RASGRP3 IGLV3-1 SKP1 PPP3R1 IGHV3-48 NFATC3 CHUK IGLV3-25 PRKCB NFATC2 IGLV3-27 PTPN6 FBXW11 NFATC1 IGKC PSMA5 IGLV3-21 FKBP1A CALM1 PSMA6 IGKV1-39 PSMA3 IGKV1-33 PSMA4 PSMA1 IGHV3-53 PSMA2 UBA52 IGLC7 CARD11 PSMD12 IGKV5-2 PSMD11 IGKV1-5 PSMD14 IGLC6 PSMD13 CUL1 BLK BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PIK3AP1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB AHCYL1 BTK PLCG2 SYK STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 PIK3R1 NCK1 LYN TRPC1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2AX TNRC6A TNRC6B RAN H3-3B H3C8 H2AJ H3C15 H2BC9 PLD6 H2BC8 H2BC5 H2BC3 H2BC1 POLR2A POLR2B POLR2C H2AB1 POLR2D POLR2E POLR2F POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 POLR2J POLR2K POLR2L BCDIN3D XPO5 DROSHA H2AC19 H2AC14 H2BC12L DGCR8 H2BC26 H2BC21 PIWIL2 TDRKH PIWIL1 TSNAX PIWIL4 PRKRA DICER1 DDX4 HENMT1 H2BC17 TARBP2 TSN ASZ1 MAEL H2BC12 H2BC13 MOV10L1 MYBL1 H2BC14 H2BC15 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 H2BC11 HSP90AA1 IPO8 H4C9 AGO3 ELAC2 H2AZ2 AGO4 ANG H2AC20 AGO1 AGO2 TNRC6C SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBA52 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF UBB UBC RPS27A CBL FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation FGF9 FGF20 FGF23 FGF22 TGFBR3 GIPC1 ANOS1 FGF10 FGF1 FGF2 FGF3 FGF4 FGF6 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 ZNF385A PSMD12 PSMD11 COP1 PSMD14 PCBP4 PSMD13 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN1B CDKN2A CCNE2 CCNE1 CDK2 TP53 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis POU3F2 DICER1 TNRC6A TNRC6B TRPM1 HDAC1 HINT1 BCL2 MOV10 AGO3 SIN3A AGO4 BIRC7 BCL2A1 AGO1 AGO2 TNRC6C DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA ABAT ALDH5A1 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN5 CLCN4 OSTM1 UNC79 STOM CALM1 UBA52 UBB UBC RPS27A SGK1 NEDD4L RYR1 RYR2 RYR3 CLIC2 CLCN6 TRDN ASPH BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SRI SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN TRPM1 TRPM2 ASIC4 ASIC5 TRPM7 CLCA2 TRPM8 FKBP1B CLCA1 TRPM5 ASIC2 TRPM6 ASIC3 TRPM3 CLCA4 TRPM4 ASIC1 TRPC7 WWP1 MCOLN3 TRPC5 TRPC6 TRPC3 TRPA1 TRPC4 WNK1 TRPC1 TRPV2 WNK2 RAF1 TRPV3 WNK3 TRPV1 UNC80 MCOLN1 MCOLN2 TRPC4AP TRPV6 TSC22D3 TRPV4 ANO8 TRPV5 ANO9 ANO6 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 PCSK5 MBTPS1 LIPC CREB3L3 LIPG APOA2 APOA4 APOA5 MBTPS2 ANGPTL8 ANGPTL3 ANGPTL4 LPA ABCG1 CETP MTTP LCAT LPL LMF2 LMF1 APOB APOF GPIHBP1 FGF21 APOE APOA1 APOC3 APOC2 ALB P4HB ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides DEFB108C CD4 DEFB130A DEFB130B ATOX1 DEFB4B GNLY DCD RNASE6 RNASE8 RNASE7 PRTN3 BPIFA1 BPIFA2 BPIFB1 BPIFB4 BPIFB6 EPPIN CHGA PDZD11 S100A7A ITLN1 S100A9 S100A8 HTN1 HTN3 SLC11A1 PGLYRP1 RNASE3 LYZ CLU SEMG1 LCN2 PLA2G2A ART1 DEFA1B PRSS3 PRSS2 DEFA6 DEFA4 CTSG DEFA5 DEFA3 PI3 S100A7 CCR6 BPIFB2 CCR2 TLR1 DEFB103B DEFB105B DEFB129 DEFB128 TLR2 DEFB131A DEFB127 DEFB126 DEFB125 DEFB124 BPI DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B PGLYRP4 DEFB119 PGLYRP3 DEFB118 PGLYRP2 DEFB117 DEFB116 DEFB115 LTF DEFB136 DEFB114 DEFB113 REG3A REG3G DEFB135 DEFB112 ATP7A CAMP DEFB134 DEFB133 LEAP2 DEFB110 DEFB132 ELANE DEFB108B DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2CA PPP2CB PPP2R1B PPP2R1A AMER1 CSNK1G2 WNT8A WNT8B AXIN1 CSNK1A1 LRP5 LRP6 GSK3B WNT1 FZD1 CTNNB1 PPP2R5E DVL1 FZD2 DVL2 FZD5 DVL3 WNT3A PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC FRAT1 CAV1 FRAT2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response GSDMD CYCS CDKN2A BAX C1QBP GSDME AVEN DIABLO CARD8 UACA CASP3 MAPK1 CASP7 APIP MAPK3 XIAP CASP9 BAK1 APAF1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis ACD LIG1 PRIM2 DSCC1 PRIM1 POLA1 POLA2 CHTF8 RFC5 CTC1 CHTF18 RFC3 STN1 RFC4 TERF1 TEN1 RFC1 TERF2 RFC2 POT1 TERF2IP FEN1 DNA2 BLM PCNA POLD3 POLD4 WRN POLD1 POLD2 TINF2 RPA1 RPA2 RPA3 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection PPIH PPIG PPIB SFN TMPRSS2 ACE2 RB1 VHL YWHAB RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC BCL2L1 RCAN3 CTSL RPS11 KPNA2 EEF1A1 RPS10 RPS13 TBK1 RPS12 RPS9 IRF3 VCP RPS7 RPS8 RPS5 RPS6 RPSA NPM1 NPIPB3 SP1 KPNB1 RPS4Y2 RPS4Y1 PIK3R4 PALS1 GSK3B NMI RPS26 TOMM70 RPS25 RPS28 RPS27 RPS29 YWHAG EP300 RPS20 PDPK1 RPS21 CASP1 RPS24 RPS23 PIK3C3 RIPK3 RPS4X CHMP4C CHMP4B RPS3A CHMP3 CHMP4A CHMP6 CANX CHMP7 TRAF6 YWHAQ RPS27L PPIA RPS15A RPS3 RPS2 FKBP1A ITCH CHMP2B CHMP2A YWHAE UBA52 FAU BECN1 UVRAG MAP1LC3B RELA RUNX1 YWHAH TRAF3 UBB IKBKE UBC RPS27A NFKB1 NFKBIA YWHAZ PSMC6 IRAK2 UBE2I ST6GALNAC2 PRKCSH CAV1 SMAD4 SMAD3 GANAB SUMO1 ST3GAL4 GSK3A MGAT1 IFIH1 PARP6 PARP4 TRIM25 ST3GAL1 GALNT1 ST3GAL2 PARP16 ST3GAL3 PARP9 ST6GAL1 PARP14 PARP8 MOGS PARP10 SIKE1 MAVS RIGI ST6GALNAC3 ST6GALNAC4 ZCRB1 PYCARD TLR7 HNRNPA1 NLRP3 PCBP2 DDX5 BST2 SFTPD STING1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAG YWHAZ PDPK1 YWHAE AKT2 YWHAH CAV1 YWHAQ AKT3 SFN AKT1 YWHAB DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h ALG8 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA SNU13 SNW1 SNRPD2 SNRPD1 SNRPD3 TCERG1 SNRPG SNRPC SRSF8 SNRPA HTATSF1 SNRPE RBM25 PPP1R10 SNRPF SNRNP70 PRPF40A TUT1 SNRPB PPP1R8 SRSF10 SRSF12 MTREX RBM39 PPIL2 NCBP1 NCBP2 FIP1L1 PPP1CB PPP1CA XRN2 PQBP1 SRRT LSM5 LSM4 LSM3 ZCRB1 SNRNP200 LSM2 LSM7 FUS LSM6 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA3 TRA2B GPKOW CDC5L RBBP6 CCAR1 PCBP1 CPSF7 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC DHX16 RBMX NUP205 HNRNPA2B1 POM121 NUP188 WBP11 AAAS POM121C PPIE NUP42 PPIH NUP62 PPIG TPR NUP88 RAE1 DDX46 NUP214 DDX42 NDC1 RBM17 NUP210 NUP155 BUD31 NUP153 NUP93 NUP50 RBM22 DDX23 NUP35 NUP54 SMNDC1 SAP18 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 EIF4E CPSF2 CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD STEEP1 SF3B4 GPATCH1 SF3B5 PNN SF3B2 SF1 SF3B3 DHX8 SF3B6 PRKRIP1 SF3B1 CWF19L2 SF3A3 WDR70 SF3A1 DHX35 SF3A2 PRPF38A XAB2 SMU1 PHF5A NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A TXNL4A CACTIN SNRPN PRPF31 SLBP RBMX2 CHERP SNIP1 IK PRP4K NUP107 LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 PTBP1 YJU2 PLRG1 LSM8 SNRPA1 PPWD1 DNAJC8 USP39 SART1 PUF60 TFIP11 SNRPB2 SYF2 C9orf78 LUC7L3 PPIL1 NSRP1 SNRNP40 WBP4 RNF113A MFAP1 RBM42 BUD13 PPIL3 PPIL4 FAM50A NUP160 SRRM2 AQR NUP85 CPSF4 CRNKL1 PDCD7 SNRNP35 PRPF19 SNRNP25 RNPC3 ZMAT5 ZRSR2 SNRNP48 HNRNPH1 HNRNPH2 SEC13 NUP133 CWC25 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 PABPN1 PAPOLG NUP43 RBM7 RANBP2 UBA52 METTL14 UBB METTL3 UBC WTAP RPS27A NUP37 HNRNPU NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 POLR2A THOC6 POLR2B SRRM1 POLR2C DDX39A POLR2D DDX39B POLR2E SARNP POLR2F ZC3H11A POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 GTF2F1 RBM8A GTF2F2 POLDIP3 SRSF1 YBX1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 ACIN1 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 DDX41 ZNF830 DHX9 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation PIK3R3 PIK3CD PIK3R2 PIK3CA PIK3R1 PIK3CB ICOSLG PIK3R6 PIK3CG PIK3R5 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 FGF9 FGF20 FGF23 FGF22 FGFR2 FGF16 FGF18 FGF10 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib HSP90AA1 CDC37 ERBIN ERBB2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex PYGO1 PYGO2 ASH2L BCL9L TCF7 BCL9 UBA52 CHD8 MEN1 CBY1 SOX9 AKT2 SOX2 UBB SRY DPY30 UBC AKT1 XPO1 RPS27A SOX17 CTBP1 WDR5 CTNNB1 YWHAZ KMT2B HDAC1 TLE3 TLE4 APC TLE2 LEF1 RBBP5 SOX3 XIAP SOX6 TCF7L2 SOX7 TLE1 SOX4 TCF7L1 BTRC CTNNBIP1 SOX13 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 NELFB CDK7 ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE NCBP1 NCBP2 CTDP1 SUPT4H1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing POM121C NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 CPSF1 CSTF2 TRMT61B CLP1 NUP107 TRMT112 NUP160 TRNT1 NUP85 CPSF4 RPP30 RPP38 RPP21 SEC13 RPP25 NUP133 RPP40 ELAC2 RPP14 NUP43 TP53RK RANBP2 RAN OSGEPL1 GTPBP3 TRMU YRDC MTO1 NUP37 POP5 POP7 TSEN15 POP1 QNG1 POP4 URM1 RTCB WDR4 THADA ZBTB8OS TSEN2 LAGE3 TSEN54 OSGEP THG1L TSEN34 ALKBH8 DDX1 C2orf49 TYW1 LCMT2 RTRAF TRMT44 XPOT TRDMT1 FAM98B PUS3 TRMT10A TYW5 METTL1 EPRS1 NSUN2 TYW3 TYW2 TPRKB ADAT1 TRMT1 CDKAL1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 ADAT2 TRMT9B QTRT1 GON7 DUS2 CTU2 QTRT2 CTU1 TRMT5 TRMT6 TRMT13 TRMT11 TRMT61A TRMT10C PRORP HSD17B10 NUP205 POM121 NUP188 AAAS BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence CBX6 PHC2 EZH2 H2AX PHC1 TNRC6A CBX4 TNRC6B CBX2 JUN PHC3 UBA52 MDM2 MDM4 BMI1 H3-3B KDM6B H3C8 RING1 FOS MINK1 UBB H2AJ UBC RPS27A RNF2 MAPK9 MAPK8 H3C15 MAP4K4 CDKN2D CDKN2B CDKN2C CDKN2A IFNB1 SUZ12 MAPK10 H2BC9 E2F1 H2BC8 E2F2 H2BC5 E2F3 H2BC3 MAPK1 H2BC1 CDK6 TFDP1 MAPK3 TFDP2 CDK4 H2AB1 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 MAPKAPK3 MAPKAPK2 TP53 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 MAP3K5 MAP2K3 MAP2K4 H4C9 RBBP4 MAPKAPK5 TNIK RBBP7 MOV10 TXN AGO3 H2AZ2 AGO4 H2AC20 MAP2K7 AGO1 MAP2K6 CBX8 TNRC6C REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels ATP2B4 SLC8A1 ATP2B3 ATP2B2 SLC8A2 ATP2B1 SLC8A3 CALM1 SRI ATP2A3 ATP2A2 ATP2A1 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors LTB4R LTB4R2 GPR17 CYSLTR1 CYSLTR2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC24B SEC24A BECN1 HLA-B ERAP2 HLA-A SEC24D B2M ERAP1 SEC24C HLA-H HLA-C HLA-F PIK3R4 ATG14 HLA-G HLA-E SEC31A CALR SEC13 PIK3C3 TAP2 TAP1 HSPA5 PDIA3 TAPBP CANX SEC23A SAR1B DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ LMBRD1 ABCD4 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np SHH IHH DHH HHAT PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis POMC FSHB INHBB INHBC CGA INHBE INHBA TSHB LHB CGB8 PCSK1 INHA DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling BTK PLCG2 TYROBP SOS1 VAV3 SYK RAC1 VAV2 KLRK1 B2M KLRD1 HLA-E PIK3CB PIK3R2 PIK3R1 PIK3CA TREM2 KLRC2 LCK NRAS HRAS PLCG1 FYN LCP2 GRAP2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation FGF9 FGF20 FGF23 FGF16 FGF18 FGF1 FGF2 FGF4 FGF6 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism SLCO1B1 SLCO1B3 AKR1C3 CH25H OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 ABCB11 ACOT8 HSD17B4 SLC27A2 OSBP CYP8B1 CYP46A1 CYP39A1 NCOA1 BAAT NCOA2 STARD5 SLC10A1 ACOX2 SLC10A2 SLC51A SLC51B HSD3B7 OSBPL1A SLC27A5 AKR1C1 AKR1D1 NR1H4 AKR1C2 ABCC3 AKR1C4 ALB CYP7B1 FABP6 CYP7A1 CYP27A1 SLCO1A2 AMACR RXRA PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing FURIN H2AX TNRC6A TNRC6B TMED2 JUN MAML2 MAML1 RFNG POGLUT1 POFUT1 PRKCI MFNG H3-3B H3C8 RUNX1 H2AJ RAB6A NOTCH1 NOTCH2 H3C15 NOTCH3 NOTCH4 CCND1 H2BC9 E2F1 H2BC8 H2BC5 E2F3 H2BC3 H2BC1 TFDP1 SNW1 TFDP2 SIRT6 H2AB1 ELF3 NOTCH2NLA ATP2A3 NOTCH2NLC ATP2A2 NOTCH2NLB ATP2A1 H2AC8 ST3GAL4 H2AC6 H2AC7 ST3GAL3 LFNG SEL1L TP53 B4GALT1 KAT2B KAT2A MAMLD1 H2AC19 H2AC14 H2BC12L ST3GAL6 H2BC26 H2BC21 EP300 H2BC17 H2BC12 RBPJ H2BC13 H2BC14 H2BC15 CREBBP H2BC11 H4C9 MOV10 AGO3 H2AZ2 AGO4 H2AC20 AGO1 AGO2 ELANE TNRC6C INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade GUCY2F NMT1 CALM1 PRKCQ NMT2 PRKCA PDE6B PDE6A RHO PDE6G SAG CNGA1 RCVRN GNAT1 PPEF1 CNGB1 METAP1 METAP2 CAMKMT RGS9BP GNGT1 GNB1 GRK1 GUCA1B GUCA1A FNTA GUCY2D GUCA1C GRK7 FNTB EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle CD4 BANF1 CCR5 KPNA1 LIG1 HMGA1 LIG4 XRCC4 XRCC6 XRCC5 CXCR4 PPIA PSIP1 FEN1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA PPIA DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 CHST6 PRELP ACAN KERA OGN OMD FMOD LUM CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling CALM1 CAMK2B RASGRF2 CAMK2D RASGRF1 ACTN2 CAMK2A RPS6KA1 GRIN2D DLG1 GRIN1 DLG3 DLG4 DLG2 LRRC7 NEFL CAMK2G PDPK1 NRAS RPS6KA3 RPS6KA2 MAPK1 HRAS GRIN2B MAPK3 RPS6KA6 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis ALAS1 PRKAG1 CALM1 PRKAG2 CYCS SOD2 PRKAG3 PPARGC1B ATP5MC2 ATP5MC3 MICOS13 MICOS10 SIRT4 ATP5MC1 MT-ATP6 APOO ATP5F1A CHCHD3 SAMM50 POLRMT ATP5F1B CHCHD6 POLG2 ACSS2 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME TWNK DMAC2L HSPA9 ATP5PF ATP5PD MTX1 APOOL SSBP1 MTX2 ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D MT-ATP8 ATP5F1E TMEM11 ATP5PO IDH2 MAPK14 SIRT3 ESRRA RXRA MAPK12 MAPK11 PPARA ATF2 CRTC2 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 CAMK4 HELZ2 PRKAB2 TGS1 PRKAB1 HCFC1 TBL1X GLUD1 GLUD2 GABPA SIRT5 MEF2D PPRC1 PPARGC1A TFB1M NCOA1 PERM1 MED1 MTERF1 NCOA2 TFAM CREBBP MEF2C TFB2M NCOA6 PRKAA2 NR1D1 NCOR1 TBL1XR1 CARM1 NRF1 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade THEM4 KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 GAB1 FRS2 FLT3 PTPN11 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ITGB1 PXN ILK PARVA VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis PARP1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD TBXAS1 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling DSCAM DOCK1 PRKCQ WASL NEO1 PTK2 HJV RAC1 SLIT2 EZR UNC5A ROBO1 UNC5B SRC UNC5C SIAH2 UNC5D AGAP2 SIAH1 DSCAML1 PITPNA TRIO NCK1 NTN4 TRPC7 DCC ABLIM1 TRPC5 ABLIM2 TRPC6 NTN1 ABLIM3 TRPC3 CDC42 SLIT1 SLIT3 TRPC4 TRPC1 PLCG1 MYO10 RGMB RGMA PTPN11 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN54 LIN52 LIN37 HDAC1 LIN9 E2F1 E2F4 E2F5 RBL2 RBL1 TFDP1 CDK1 RBBP4 TFDP2 CCNA2 MYBL2 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin PDS5A NIPBL RAD21 WAPL MAU2 STAG1 SMC1A STAG2 PDS5B SMC3 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A4 SLC4A10 SLC26A3 SLC12A2 SLC4A8 SLC12A3 SLC4A9 SLC12A4 SLC26A7 SLC12A5 SLC26A9 SLC12A1 SLC26A6 SLC12A6 SLC12A7 SLC13A1 SLC20A2 SLC13A4 SLC4A1 SLC26A11 SLC5A8 AHCYL2 SLC4A2 SLC26A2 SLC4A3 SLC4A7 SLC4A5 SLC34A3 SLC34A2 SLC26A1 SLC34A1 SLC20A1 SLC17A1 SLC5A5 SLC4A4 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events CXCL8 SRC SSTR3 MAPK1 C5AR1 RXFP4 RLN3 INSL5 RXFP3 OPN1SW C3 C5 PPP3CA PPP3CB PPP3R1 CALM1 CCR5 APP PRKACG PPP1R1B PRKACB CCL4L2 RGS8 PCP2 GPSM1 CDK5 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 GNGT1 OPN1MW CHRM2 PPP1CA POMC CHRM4 GNGT2 GNAT3 C3AR1 RGS9 RGS6 ADCY9 RGS7 PRKAR1B HRH4 PRKAR2B DRD3 DRD4 HTR1E HTR1F GNAI3 HTR1D ADCY4 ADCY3 HTR1B PRKX CX3CR1 ADCY2 HTR5A ADCY1 ADCY8 GNAQ GNG10 ADCY7 PRKAR2A ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 CAMK4 GNG8 CXCR4 GNAZ CXCL12 GNA14 GNA15 GNA11 GNG12 GNG11 GNG13 GNB2 GNB1 PF4 GNAS RGS11 PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR31 RGR CCL13 CCL19 PLCB4 CCL16 P2RY12 CCL25 P2RY13 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 CXCL13 CXCL16 ADORA3 ADORA1 MTNR1A MTNR1B PSAP CXCL10 CXCL11 ANXA1 P2RY4 CCL5 CCL4 CCL1 APLN TAS2R20 RRH OXER1 TAS2R10 PRKCG TAS2R13 TAS2R14 TAS2R16 KPNA2 GPR37L1 TAS2R19 PPP2R1B TAS2R40 PPP2R1A TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GNAL PENK PPY NBEA CCR10 CCR1 TAS2R30 TAS2R31 PPBP TAS2R38 ADRA2C TAS2R39 ADRA2B TAS2R60 ADRA2A PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 CAMKK1 CAMKK2 GAL OPRD1 NPB PTGER3 CXCR5 CXCR6 CXCR1 PPP2R5D NPW CXCR3 CXCR2 GABBR2 GABBR1 NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 PPP2CA TAS2R9 PPP2CB CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 CXCL5 HEBP1 RGSL1 GRM3 GRM2 GRM4 GRM7 GRM6 GPER1 GRM8 TAS2R1 TAS2R3 TAS2R5 TAS2R4 LPAR1 RHO LPAR2 NPY5R LPAR3 SSTR1 GNAT1 FPR2 SSTR2 SSTR4 SSTR5 CORT NPY4R GPR17 OPRL1 CNR2 CNR1 TAS1R2 LPAR5 S1PR3 TAS1R1 NMS S1PR2 NMU S1PR5 TAS1R3 S1PR4 NPY ACKR3 SAA1 AHCYL1 AGT MT-RNR2 PRKACA PDE1C GNAT2 PDE1B PDE1A PMCH RGS4 GRK2 PRKCD PRKCA RGS5 PLCB3 PLA2G4A PLCB1 RGS3 PLCB2 RGS1 OPRM1 CAMK2B CASR CAMK2D CAMK2A ITPR1 ITPR2 KNG1 MCHR2 ITPR3 PRKAR1A NMUR2 NMUR1 CAMK2G OPRK1 PPP3CC MCHR1 BDKRB2 BDKRB1 RGS18 RGS17 RGS19 RGS13 RGS16 RGS21 SST SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription RB1 ZCRB1 VHL DDX5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism MTRR MTR CBLIF ABCD4 CUBN MMAA AMN CD320 MMUT LMBRD1 TCN2 MMAB MMACHC MMADHC ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling AHRR ARNT ARNT2 AIP PTGES3 HSP90AB1 AHR DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions DSCAM NTN1 DCC DSCAML1 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia ASS1 NMRAL1 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO2B1 SLCO2A1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO1A2 AVP SLCO4A1 SLCO4C1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 ITGA2B CSNK2B PAK1 ITGB1 ITGB3 ITGAV ITGA5 RAC1 EGFR VAV2 MAPK1 ITGA9 NCAM1 MAPK3 MAP2K1 NRP1 MAP2K2 L1CAM CSNK2A1 CSNK2A2 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation ITGA2B F13B F13A1 ITGB3 SERPINC1 FGB FGA SERPIND1 FGG F2 PROC SERPINE2 SERPINA5 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis SERPINA1 F5 F8 F12 KLKB1 RAC1 H3-3B F7 H3C8 F9 VAV1 PROZ H3C15 NOS3 KIF20A IFNB1 KLC1 KLC4 F10 KLC3 KLC2 DOCK3 KIF11 KIF15 PLCG1 KIF23 EGF KIF22 CLU CD74 SERPING1 KIF26A TF DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI DGKH HGF PIK3CB PIK3CG RHOB PDPK1 DOCK10 PIK3CA PLAT SERPINB8 SERPINB6 LCK JMJD1C PLAU IRF1 S100A10 HBE1 GATA5 AK3 SPN PPIL2 MICAL1 CARMIL1 CDC42 PCDH7 HBG2 HBG1 EHD1 EHD2 EHD3 FYN MAFF CSK RACGAP1 HBD AKAP10 SH2B1 CABLES2 PTPN11 PTPN6 PDPN MPIG6B FCER1G GP6 PRKACG PDE2A PRKACB GNA13 TBXA2R GNA12 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 SLC3A2 GTPBP2 SYTL4 SLC7A11 PDE11A CD109 TAGLN2 NHLRC2 SLC7A10 PDE10A STXBP3 TEX264 STXBP2 PDGFB ENDOD1 A1BG APOH VTI1B RAB27B MANF A2M CALU MAGED2 HRG FERMT3 CEACAM6 SERPINA3 CABLES1 ORM1 ECM1 WEE1 OLA1 CEACAM8 SLC7A5 CTSW SLC7A6 ORM2 MMP1 SERPINA4 SLC7A7 EPCAM TMSB4X SLC7A8 TIMP3 SLC7A9 ALB QSOX1 AHSG ANXA5 RAPGEF3 NOS2 RAPGEF4 TOR4A GNAT3 CD63 SPP2 LEFTY2 LY6G6F VEGFB PRKAR1B VEGFC VEGFD LHFPL2 PRKAR2B PCYOX1L PLCG2 MPL F13A1 TUBA4A POTEKP CFL1 FAM3C APLP2 SYK TMX3 TP53 GNAI3 SELENOP SCG3 THPO RARRES2 HSPG2 CYRIB VPREB3 SELP VPREB1 SCCPDH CXADR ACTN2 GNAQ LGALS3BP WDR1 PSG1 SDC4 PSG3 SDC2 PLEK PHACTR2 PSG2 SDC3 GNAI1 PSG9 SRGN FCAMR GNAI2 MMRN1 PECAM1 PSG8 ITIH4 PSG5 ITIH3 PSG4 PLG PSG7 TTN PSG6 CLEC3B GYPA CDC37L1 GYPC AAMP GYPB BCAR1 CD99L2 GLG1 OLR1 CEACAM3 CD48 SDC1 SELPLG CD58 IGLL1 CD84 SIRPG SIRPA JAML PSG11 CD99 GNA14 GRB7 SELE SELL GNA15 ESAM TREM1 FGR GNA11 CD2 CD244 P2RX7 DOCK11 P2RX4 ALDOA GATA4 GATA3 PHF21A CD44 GATA2 KCNMB1 GATA1 KCNMA1 RCOR1 IGHM HMG20B GPC1 INPP5D GPC3 GPC2 DOCK6 ITPK1 DOCK9 GPC5 GPC4 GPC6 AGRN CD9 ZFPM2 PRKCG BSG TSPAN7 VPS45 SLC16A1 TGFB1 PICK1 DOCK8 PRKCB PAFAH2 MFN1 MFN2 DOCK7 RBSN PROS1 HSPA5 MERTK GAS6 ANGPT1 TEK SERPINE2 SERPINA5 THBD SMPD1 PF4V1 CD177 PROCR F11 DOK2 F13B BRPF3 CD36 TNFRSF10D PRKG2 PRKCA ANGPT4 KIFAP3 ANGPT2 GRB14 ITGAL PRKAR1A ITGA4 RAD51B RAD51C KIF3B KIF3A SERPINB2 ITGA5 MIF TRPC7 MAFG KIF3C TRPC6 TRPC3 PTPN1 ANO6 ANO5 SOD1 FN1 SRC AKAP1 SHC1 IGHV3-23 NRAS IGLV RAP1A IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 HRAS IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 P2RX6 P2RX5 V2-11 IGHV3-30 P2RX3 V3-4 P2RX2 V3-3 P2RX1 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ SOS1 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 IGLV2-11 VEGFA IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 F11R V2-8 PRKCZ V1-20 HBB CEACAM1 IGKV2D-40 RHOA IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 APOB ITGB1 CLEC1B IGKV3-20 IGHV4-34 IGHV1-2 DOCK5 IGHV1-46 IGHV4-39 DOCK4 IGHV IGKV2-29 IGKV2-28 IGLC3 APOA1 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 LAMP2 V1-5 SLC16A8 MAFK V1-3 IGKV3D-20 V5-6 SLC16A3 IRAG1 PDE9A IGLV3-19 RHOG IGKV2-30 IGHV2-70 PPIA IGHV2-5 RASGRP1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC DOCK2 IGLV3-21 DOCK1 CALM1 IGKV1-39 IGKV1-33 V4-6 LRP8 IGHV3-53 APP V4-2 IGLC7 V4-1 IGKV5-2 SERPINE1 IGKV1-5 IGLC6 MYB PRTN3 CDK5 YWHAZ NFE2 RAC2 HDAC1 GNGT1 GNGT2 CAV1 ITGAM PROC ITGB2 IFNA5 IFNA4 IFNA7 IFNA6 MGLL IFNA1 IFNA2 IFNA8 ITGAX IFNA21 CD47 JAM2 IFNA14 JAM3 IFNA16 VAV3 IFNA17 ITGAV ABCC4 ANXA2 PTK2 IFNA10 GP9 PFN1 GP1BB VAV2 FLNA GP5 GNG10 PRKAR2A RAB5A GNG3 CYB5R1 GNG2 GNG5 CAP1 GNG4 IGF2 GNG7 IGF1 GNG8 GATA6 KDM1A ACTN1 PDE5A KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 GNB2 GNB1 PF4 GNAS GNB4 GNB3 GNB5 ITGA2B MAG P2RY12 L1CAM GUCY1B2 KIF4B GUCY1B1 KIF4A ITGA10 F3 PSAP GUCY1A2 GUCY1A1 ABL1 CDK2 PPP2R1B PPP2R1A PPBP ADRA2C ADRA2B ADRA2A CEACAM5 SIN3A KIF18A PPP2R5E PPP2R5B PPP2R5A ADAMTS13 HDAC2 PPP2R5D PPP2R5C ITGA3 ITGA2 IRF2 ITGA1 KIF2A ITGA6 KIF2C KIF2B PLAUR PPP2CA TNFRSF10B PPP2CB TNFRSF10A CENPE ZFPM1 PTGIR GP1BA SH2B3 SH2B2 APOOL SERPINC1 STX4 CAPZB F2 CBX5 ATP2A3 CAPZA1 ATP2A2 CAPZA2 ATP2A1 SLC8A1 TIMP1 SLC8A2 TGFB2 NOS1 PRKACA F2RL2 F2RL3 ATP1B3 PDE1B ATP1B2 PDE1A ATP1B1 PRKCD STIM1 KIF5C PLA2G4A ORAI2 ORAI1 KIF5B IGHA1 KIF5A IGHA2 F2R JCHAIN ITPR1 KIF28P KIF12 ITPR2 KNG1 KIF19 ITPR3 KIF13B KIF1C THBS1 SRI KIF21A AKT1 KIF1B KIF21B TGFB3 SERPINA10 KIF1A KIF25 KIF6 KIF27 ATP2B4 ATP2B3 CFD KIF9 ATP2B2 KIFC2 ATP2B1 SLC8A3 KIF16B KIFC1 ITGB3 KIF20B ARRB1 PIK3R3 PIK3R2 ARRB2 PIK3R1 RAP1B KIF18B JAK2 PIK3R6 KIF26B PIK3R5 FGB SERPIND1 FGA LYN VWF P2RY1 FGG YES1 APBB1IP RAF1 TLN1 VCL LCP2 LAT DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 GNE CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress BAG5 HTRA2 CBX6 HSPH1 PHC2 DNAJA1 ACD EZH2 DNAJB6 DNAJA4 PHC1 BAG3 LONP1 H2AX HSF1 CBX4 BAG1 CBX2 AMER1 HSPA4 HMGA2 ST13 H1-1 PHC3 HSPA7 H1-0 HSPA6 H1-3 HSPA12A H1-2 HSPA12B H1-5 H1-4 IL6 MDM2 PREB MDM4 CXCL8 BMI1 H3-3B CABIN1 VENTX CHAC1 H3C8 KDM6B RING1 FOS TCIRG1 MINK1 GOSR2 TERF1 TERF2 H2AJ CCNA2 ATP6V1E1 CCNA1 POT1 ATP6V1E2 ATP6V0B TERF2IP CEBPB ATP6V1G1 SEC31A ATP6V0E1 RNF2 ATP6V1G2 HIRA MAPK9 H3C15 MAPK8 MAPK7 UBN1 MAP4K4 ATP6V1B2 CDKN2D ATP6V0D1 CDKN2B ATP6V0C CDKN2C ATP6V0D2 CDKN2A IFNB1 ABCG2 SUZ12 ATP6V1B1 VHL MAPK10 H2BC9 ATP6V1A H3-4 H2BC8 H2BC5 H2BC3 STAT3 ATP6V1H H2BC1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 EGF HMOX2 BCL2 PDGFA ATP6V1F AREG ATP6V1C2 BCL2L1 H2AB1 EEF1A1 H2AC8 H2AC6 H2AC7 VCP EPO CA9 HIGD1A GSK3B H2BC26 H2BC21 MLST8 NCF1 NCF2 EED NCF4 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CYBB PRKAA2 ARFGAP1 CYBA RBBP4 RBBP7 H2AZ2 MTOR TNRC6C TNRC6A TNRC6B EIF2S3 EIF2S2 CREB3L3 EIF2S1 ELOB ELOC FBXL17 MAP1LC3B SLC7A11 PTK6 ALB P4HB IDH1 HYOU1 TP53 TALDO1 MT-CO1 NLRP3 STIP1 UFD1 DDIT3 TXNIP MT-CO2 MT-CO3 NUP205 POM121 NUP188 AAAS POM121C DNAJB11 SZT2 NUP42 SAMTOR TKT NUP62 SEH1L TPR NPRL2 NPRL3 NUP88 RAE1 GCN1 WDR59 NUP214 EIF2AK4 NDC1 FLCN NUP210 MIOS EXTL2 ITFG2 NUP155 IMPACT HMGA1 KPTN NUP153 NUP93 DEPDC5 WDR24 NUP50 SH3BP4 NUP35 FNIP1 NUP54 FNIP2 KICS2 CASTOR1 EXTL3 CASTOR2 ADD1 FKBP14 HERPUD1 MYDGF TATDN2 SERP1 CREB3L4 CREB3L1 RPL4 CREB3L2 NPLOC4 RPL5 TSPYL2 RPL30 DDX11 RPL3 WIPI1 RPL32 PDIA6 RPL31 PDIA5 RPL34 PGD ERN1 RPL10L CREB3 RPL10A DCSTAMP RPL8 CTDSP2 RPL6 KDELR3 RPL7 ATF6B DCTN1 CEBPG RPS15 CXXC1 RPS14 EXTL1 HSPA1B RPS17 SSR1 RPS16 DNAJB9 RPL18A ZBTB17 RPS19 RPS18 KLHDC3 WFS1 RPL36AL RPL36 EDEM1 BAG2 ASNS RPL35 YIF1A CREBRF RPL38 SRPRA SRPRB RPL37 SIRT3 TPP1 RPS11 HDGF RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA DNAJA2 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A UBE2D3 DNAJC3 PSMD8 RPL37A EIF2AK1 PSMD6 ATF5 RPL10 PSMD7 RPL12 TXN2 PSMD2 RPL11 PSMD3 SESN2 RPL36A PSMD1 RPS27L RPS15A BTRC RPL14 RPS3 SKP1 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A SULT1A3 PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 HSPA1A PSMD14 PSMD13 PRKCI CUL1 DCTN6 DCTN5 PSMA7 DCTN4 RELA PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA5 RORA NR3C1 ABCC1 ESR1 NR3C2 AR RXRA GSK3A PGR PPARA MRE11 LMNA BRCA1 KAT5 OMA1 NBN COX4I1 COX4I2 EIF2AK3 AQP8 NUDT2 ATF4 PRDX3 ARNT PRDX6 NOX5 UBXN7 GSTP1 NQO1 GSTA3 ERO1A SESN1 MUL1 DPP3 STAP2 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 GPX1 GPX3 RPA1 GPX6 RPA2 PALB2 GPX5 GPX8 GPX7 RAD50 ATP7A BLVRB RPA3 BLVRA HM13 CCL2 ABCF2 TXNRD2 ATM SOD3 ATOX1 ATR SOD1 CCS ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 STOML2 PHB2 YME1L1 SHC1 UBE2D2 MAPK1 MAPK3 COX7B COX7C MAPK14 COX8A MAPK11 PLA2G4B COX8C MAPKAPK3 MAPKAPK2 COX5B DCTN2 COX5A DCTN3 COX6C ATF2 VEGFA CRTC2 SLC46A1 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 LY96 COX6A1 HBB COX6A2 BACH1 NPAS2 HELZ2 G6PD RAI1 XPO1 PGRMC2 COX6B2 TGS1 COX6B1 NRIP1 HMOX1 EP300 ATF6 TBL1X APOB HIGD1C CLEC1B MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 APOA1 HBA2 NR1D1 SIRT1 HSPA1L NCOR1 TBL1XR1 CARM1 MAFK TLR4 BMAL1 CLOCK NFE2L2 HSPA2 CAT DIS3 YWHAE PARN JUN EXOSC7 EXOSC6 EXOSC5 SOD2 EXOSC4 FOXO3 EXOSC9 KHSRP EXOSC8 EXOSC3 LMNB1 EXOSC2 PRDX2 EXOSC1 RPS6KA1 PRDX1 HSPE1 NOTCH1 RBX1 FABP1 ID1 NCOR2 GSTA1 HSP90AB1 DCP2 NOX4 CUL2 SYVN1 FKBP4 PTGES3 CUL3 RPTOR IGFBP1 RRAGA RRAGC RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 GFPT1 LAMTOR5 FKBP5 RB1 CDKN1A CDKN1B FZR1 E2F1 SQSTM1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 HIF3A CDK4 CCNE1 CDK2 ACADVL NUP107 HSPA8 MBTPS1 DYNC1LI1 DYNC1LI2 NFYA NFYB NFYC SP1 NUP160 MBTPS2 NUP85 SIN3A GPX2 RPS27 SEC13 NUP133 PPP2R5B DYNLL1 IL1A DYNLL2 HDAC6 DYNC1I2 TXNRD1 KEAP1 NUP43 DYNC1I1 RANBP2 CYCS TRIM21 DYNC1H1 COX7A2L CITED2 NUP37 HSPA9 COXFA4 CAPZB COX7A2 COX7A1 LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP CAPZA1 CAPZA2 DEFA5 PRKCD CAMK2B CAMK2D PPP1R15A CAMK2A H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 HSPD1 AKT1 HSP90B1 CAMK2G CSNK2A1 CUL7 CSNK2A2 CSNK2B TRIB3 ATF3 EPAS1 HIF1A EHMT2 EHMT1 GRB10 ETS1 ETS2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 HSPB8 HIKESHI MAP2K4 H4C9 CCAR2 TINF2 HSBP1 ERF MAPKAPK5 AJUBA DNAJC2 TNIK DNAJC7 TLN1 ASF1A MOV10 CRYAB AGO3 TXN RPS19BP1 HSPA4L AGO4 EP400 H2AC20 HSPA14 IGFBP7 AGO1 HSPA13 MAP2K7 NRF1 MAP2K6 DNAJB1 BAG4 DELE1 CBX8 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type MMUT MMAA EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection UBA1 MAGT1 VTN H3C8 CTNNB1 H3C15 RICTOR H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 SNW1 TUSC3 ELAVL1 C4BPA C4BPB CLU NEK2 H2AC8 H2AC6 EXOC1 H2AC7 TMEM258 VCP OST4 SNRPD2 SNRPD1 SNRPD3 GBF1 OSTC STT3A SNRPG STT3B SNRPE LY96 PRR5 SNRPF SNRPB XPO1 H2BC26 H2BC21 MLST8 CD209 H2BC17 C4A DDOST H2BC12 C4B_2 H2BC13 H2BC14 H2BC15 DAD1 APOA1 H2BC11 TLR4 MTOR HDLBP NMT1 H2BC18 AP2A1 COG1 AP2A2 AP2M1 BECN1 MAP1LC3B NCBP1 NCBP2 FIP1L1 AP2S1 ACOT2 AP2B1 P4HB IFIH1 TRIM25 GRPEL1 HYOU1 MAVS PQBP1 HSPG2 SDC4 TAL1 ATL2 NCL SDC2 SRRT SDC3 SNRNP200 PABPC1 FUS HSP90AB1 XRN1 NACA ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA0 HNRNPA3 SDC1 GPKOW CDC5L KDELR1 CCAR1 CD2BP2 PCBP1 CPSF7 PCBP2 RBM10 DDX5 RETREG1 SUGP1 DHX15 VIM HNRNPC DHX16 UFD1 RBMX PEX19 HNRNPA2B1 WBP11 HNRNPUL1 DNAJB11 PPIE FURIN DPM1 DPM2 RTN3 DPM3 DDX3X KPNA1 DDX46 RPTOR DDX42 RBM17 SUN2 DYNLT1 GPC1 BUD31 MMP9 GPC3 RBM22 DDX23 GPC2 RRBP1 SMNDC1 GPC5 U2SURP HNRNPR GPC4 STAT2 NRBP1 GPC6 CPSF1 CSTF3 ATG14 CPSF3 CSTF2 EIF4E CPSF2 AGRN CSTF2T BTF3 WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK EIF4G1 NPLOC4 PAPOLA SYMPK HNRNPF HNRNPD CLINT1 SF3B4 HAVCR1 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HSPA1B DAXX AUP1 IPO7 CLEC5A TXNL4A SNRPN KPNA7 BAG2 CHERP KPNA4 P4HA1 P4HA2 KPNA5 P4HA3 EIF4G3 KPNA2 HSPA8 EIF4G2 KPNA3 EIF4E3 PTBP1 SCAP PLRG1 SNRPA1 DNAJC8 PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 RPSA DNAJA2 PPIL3 PPIL4 PPIL6 SRRM2 KPNB1 AQR CPSF4 CRNKL1 PIK3R4 PRPF19 HNRNPH1 HNRNPH2 CALR SPCS3 SPCS2 SPCS1 CWC25 PDCD6IP PIK3C3 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 HSP90AA1 CWC15 DNAJC10 ELAVL2 RBM5 DNAJC3 CANX RIPK1 PABPN1 RPL18 UBA52 HSPA1A CDC73 TAOK1 SKIC8 CTR9 RTF1 CD14 UBB IKBKE ATG7 LEO1 UBC RPS27A PAF1 NFKBIA FASN RNASEK PROS1 EIF4A2 HNRNPU CLDN1 EIF4A1 MRC1 EMC4 NFKBIB CD33 HSPA5 CD300A TIMD4 TJP1 EIF4A3 MERTK AXL TYRO3 UBE2I MAPRE3 GAS6 LY6E F2 CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D POLR2E POLR2F SUMO1 POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SRSF9 GTF2F1 GTF2F2 PRKG2 SRSF1 YBX1 U2AF1 U2AF1L4 H2AC17 H2AC12 U2AF2 DHX38 CAMK2B SRSF11 CAMK2D H2AC1 CAMK2A ALYREF H2AC19 H2AC25 H2AC14 H2AC21 RNPS1 CAMK2G UBA7 UBA6 UBA5 UBR4 MBL2 RPN2 MAPKAP1 C1QA RPN1 C1S PIK3R1 TSG101 CGAS LYN H4C9 DHX9 H2AC20 STING1 UBA3 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation GOT2 AGXT2 AMT PRODH2 GCSH GNMT KGD4 AGXT GLDC DDO HAO1 HOGA1 GRHPR DLD PXMP2 DAO OGDH DLST ALDH4A1 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border PAX7 CTNNB1 DLX5 MSX1 TFAP2A TFAP2B WNT3A POU5F1 TFAP2C MYB ZIC1 SOX2 TCF7L1 GBX2 FGF4 PAX3 BMP4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions NRCAM CNTNAP1 NFASC ANK1 SDCBP DCX CNTN1 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy ATM MTMR14 PRKAG1 HSF1 PRKAG2 RPTOR PRKAG3 TSC2 TSC1 RRAGA RRAGC RRAGB RRAGD MTMR3 ATG14 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 WIPI1 VDAC3 VDAC2 VDAC1 UBE2D2 SQSTM1 HSPA8 TBK1 VCP UBE2V1 DYNC1LI1 DYNC1LI2 PCNT PIK3R4 TOMM70 MLST8 TOMM20 UBE2L3 TOMM22 UBE2N ARL13B PIK3C3 DYNLL1 CETN1 PRKAA1 PARK7 HSP90AA1 PRKAA2 CHMP4C DYNLL2 CHMP4B HDAC6 CHMP3 UBE2D3 CHMP4A PLIN2 CFTR CHMP6 GABARAPL3 CHMP7 ATG3 GABARAPL1 ATG9B PRKN ATG10 DYNC1I2 ATG13 ATG101 ATG16L2 ATG16L1 MTOR WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B CHMP2B ATG4A CHMP2A ATG4D TOMM40 DYNC1I1 WDR45B AMBRA1 UBA52 DYNC1H1 BECN1 UVRAG MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN ATG7 UBC RPS27A MAP1LC3A GABARAP FUNDC1 USP30 ATG9A ATG12 PEX5 ATG5 NBR1 GABARAPL2 PLIN3 ULK1 PRKAB2 IFT88 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B EPAS1 MTERF3 PINK1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules LRFN1 GRIA1 FLOT1 RTN3 FLOT2 GRIA3 GRIA4 PTPRS PTPRF GRIN2C GRIN2B GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 PTPRD LRFN3 LRFN2 LRFN4 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism MMUT MMAA RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress CHUK PPP2CA CALM1 PRKACG PRKACB FLT4 RELA CAPNS1 CAPNS2 CAPN2 IKBKE PANX1 YAP1 NFKB1 NFKBIA CTNNB1 KDR NOS3 RICTOR ADM GNGT1 ABL1 STAT1 GNGT2 CDH5 ADCY9 PRKAR1B PPP2R1B PRKAR2B PPP2R1A RAMP2 PPP2R2A PIEZO1 PRKACA ITGAV CALCRL ANXA2 MMP14 PTK2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GNAQ ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ADCY5 GNG2 PRR5 PECAM1 GNG5 GNG4 PIK3CD GNG7 PRKAR1A GNG8 PIK3CB AKT1 MLST8 PDPK1 ITGB1 ITGB3 MAPKAP1 ITGA5 PIK3R2 PIK3CA P2RY2 GNA11 GNG12 GNG11 GNG13 IKBKB FYN GNB2 TLN1 PTPN1 VCL GNB1 GNAS PKN2 GNB4 IKBKG GNB3 TRPV4 GNB5 MTOR DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology WDR5 TBL1X CALM1 ASH2L PRKACA HDAC1 NCOR2 HDAC3 NCOR1 TBL1XR1 RBBP5 DPY30 SIN3A CAMK4 GPS2 KMT2D JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAPK9 UBE2N MAPK8 TAB3 TAB2 TAB1 IRAK1 UBE2V1 MAPK10 NOD1 NOD2 RIPK2 IRAK2 MAP2K4 TRAF6 IKBKG MAP2K7 MAP3K7 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines ALDH1L1 MTHFD1 ALDH1L2 MTHFD2 MTHFD2L SHMT1 FOLR2 SHMT2 SLC19A1 MTHFR MTHFS DHFR SLC46A1 SLC25A32 DHFR2 MTHFD1L DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling UBE2D1 RAC1 LINGO1 USP2 MAG OMG RTN4 VAV1 MAPK8 RACK1 UBE2D2 NGFR CASP10 SQSTM1 MIB2 TIAM1 SORCS3 NGF TBK1 MAPKAPK2 SOS1 ADAM17 RASGRF2 HDAC3 SPPL2B SPPL2A ARHGEF18 SMPD3 SMPD2 CLIP3 RHOA TAX1BP1 NSMAF ARHGEF10L BAD OTULIN AKAP13 TRADD ARHGEF11 ARHGEF9 ARHGEF10 CFLAR UBE2L3 ARHGEF12 CASP8 ARHGEF17 TAB3 TAB2 BEX3 TAB1 TNFSF10 IRAK1 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 HDAC2 TRAF2 ECT2 PREX1 ARHGDIA UBE2D3 MCF2L NET1 IKBKB BIRC2 ABR TRAF6 ITGB3BP BIRC3 ARHGEF16 XIAP RIPK1 IKBKG FADD MAP3K7 ARHGEF40 PLEKHG2 CHUK TNFRSF10B ARHGEF15 PLEKHG5 TNFRSF10A ARHGEF19 ARHGEF5 TIAM2 OBSCN YWHAE ARHGEF4 FAS TNF ARHGEF26 ARHGEF7 UBA52 NGEF FASLG ARHGEF6 STUB1 FGD1 FGD2 KALRN GNA13 FGD3 PRKCI FGD4 RIPK2 TNFRSF1A MYD88 RBCK1 BCL2L11 ARHGEF33 RELA ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 UBB AATF IKBKE PSENEN OPTN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A PRDM4 APH1B NFKB1 NFKBIA HDAC1 CASP3 RNF31 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 ULK1 VAV3 TNFRSF10D CASP2 VAV2 SOS2 BAG4 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F9 F8 F10 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA MAPKAPK2 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 YWHAB EXOSC8 EXOSC3 EXOSC2 EXOSC1 ZFP36L1 AKT1 XRN1 DCP1A DCP2 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization USP7 PTEN UBB UBA52 XIAP NEDD4 UBC RPS27A PML FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 NELFB CDK7 ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE NCBP1 NCBP2 CTDP1 SUPT4H1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) HSD17B6 STRA6 HSD17B1 RDH12 RDH8 CYP4V2 LRAT RLBP1 MYO7A DHRS9 TTR RDH11 RHO ABCA4 RDH10 RPE65 RBP4 RDH16 RDH5 SDR9C7 RBP3 RBP1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm PAX8 LHX1 OSR1 FOXC2 FGF2 FOXC1 PAX2 BMP4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL TUBGCP2 TUBGCP5 TUBGCP6 OFD1 TUBGCP3 CPAP TUBGCP4 TUBG2 MZT2B MZT2A NME7 MZT1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CDK11A CDK11B CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome UACA MAPK1 APIP MAPK3 CYCS XIAP CASP9 AVEN DIABLO APAF1 CARD8 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway FN1 IL6 JAK1 CDK1 SRC TGFA MET SHC2 SHC3 ICMT SHC1 YWHAB NRAS RAP1A FRS3 MAPK1 GRIN2B HRAS RALGDS MAPK3 MAP2K1 MAP2K2 EGF FRS2 BRAF AREG BCL2L1 MAPK12 PRKCQ SOS1 NRG2 NRG3 RASGRP4 NRG4 HGF GFRA1 PIK3CB GDNF PDE6D PIK3CA IL2 IL3 FYN CSK RASGRP1 PTPN11 RASGRP3 CALM1 KRAS PDGFRA PDGFB RBX1 KIT PPP1CB MARK3 RET GOLGA7 PTK2 ZDHHC9 ARL2 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 PPP5C NEFL FNTA CSF2 FNTB ITGA2B SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 IL2RG JAK3 RASAL3 DAB2IP NF1 KBTBD7 TYK2 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 LAMTOR2 LAMTOR3 EREG SPTAN1 BTC SPTB EPGN HBEGF NCAM1 RANBP9 FLT3 DUSP16 PPP1CC PPP2R1B PPP2R1A EGFR RASGRF2 LYPLA1 RASGRF1 KLB DLG1 IRS1 DLG3 DLG4 IRS2 FGF1 FGF2 FGF3 NRG1 ABHD17C USP17L2 FGF4 FGF6 ABHD17B FGF7 ABHD17A RCE1 FGF9 FGF20 FGF23 PPP2R5E FGF22 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A FGF10 PPP2R5D PPP2R5C PSMD8 PSMD6 IL6R PSMD7 PSMD2 DUSP10 PSMD3 DUSP5 PSMD1 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PPP2CA PTPN3 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DUSP4 PDGFRB ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 FLT3LG PSMC1 PSMC2 WDR83 PTPRA RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 SHOC2 ARTN RASGEF1A GFRA3 GFRA2 ANGPT1 GFRA4 TEK NRTN PTPN7 PSPN PRKG2 CAMK2B CAMK2D CAMK2A ERBB2 CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 PIK3R2 IQGAP1 PIK3R1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 IL5RA CNKSR1 CSF2RB RAF1 CSF2RA TLN1 IL5 VCL IL2RB MAP3K11 IL3RA IL2RA KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway SOD3 TKT AMER1 CUL3 NPLOC4 PGD CDKN1A CDKN2A ABCG2 SQSTM1 SKP2 EGF BCL2 PDGFA AREG BCL2L1 VCP SP1 GSK3B BACH1 G6PD HMOX1 EP300 CREBBP PRKAA2 PSMD8 MAFK PSMD6 PSMD7 PSMD2 NFE2L2 SESN2 PSMD3 PSMD1 TXNRD1 BTRC KEAP1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 TRIM21 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRKCI CUL1 MAP1LC3B FBXL17 PSMA7 RELA PSMB6 PSMB7 PRDX1 PSMB4 PSMB5 UBB SLC7A11 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NOTCH1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABCC1 IDH1 BRCA1 TALDO1 PRKCD GSTA1 AKT2 MYC AKT3 AKT1 EIF2AK3 CSNK2A1 CSNK2A2 CSNK2B ATF4 UBXN7 NQO1 GSTA3 SESN1 MUL1 DPP3 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 UFD1 PALB2 TXN CCL2 ABCF2 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA SLC6A1 SLC6A13 SLC6A12 SLC6A11 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD SLC35D1 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle VCP RAB7A VAMP3 MTR WDR11 UACA PAK4 TFRC RALGAPA1 DBT FAM91A1 SLC1A5 TUBA1B NSFL1C VANGL1 ROCK1 ROCK2 LAMTOR1 PAK6 PAK5 PAK1 NIPSNAP2 PAK2 SLC4A7 LCK ARHGDIG STOM RHOH JUP ARHGDIA ARHGDIB DBN1 CSK CAV1 ZAP70 TMEM59 OSBPL11 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling INHBA ACVR2A TGFBR3 INHA PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA H2AC6 H2AC7 EZH2 H2AX DNMT3B DNMT3A DNMT1 H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 AEBP2 H3C15 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SUZ12 EZH1 H2BC9 PHF19 H2BC8 EPOP PHF1 H2BC5 H2BC11 JARID2 H2BC3 MTF2 H2BC1 H4C9 EZHIP RBBP4 RBBP7 H2AB1 H2AZ2 H2AC20 H2AC8 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 ABCA3 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation RAB40A RAB40B RAB40C RAB7A RAB1A RAB1B RAB2A RAB6A RAB6B RAB3B RAB8A RAB9A RAB3C RAB9B RAB3D RAB44 RAB41 RAB42 RAB27B RAB2B RAB30 RAB36 RAB37 RAB8B RAB34 RAB4B RAB4A RAB33A RAB33B RAB32 RAB11B PTP4A2 RAB31 RAB38 RAB20 RAB35 RAB25 RAB26 RAB23 RAB24 RAB7B RAB21 RAB29 CHM CHML RAB15 RAB19 RAB17 RAB39A RAB27A RAB39B RAB12 RAB18 RAB5B RAB5C RAB11A RAB5A RAB3A RABGGTB RABGGTA RAB22A RAB10 RAB14 RAB13 RAB43 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells CBFB RUNX1 LGALS3 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CDC34 UBA1 UBE2K UBE2C UBE2Z UBA52 UBE2E1 UBE2D1 UBE2Q2 UBE2E3 UBE2S USP7 UBE2R2 UBB UBC OTULIN RPS27A USP9X UBE2L3 UBA6 UCHL3 USP5 UBE2D2 UBE2H UBE2G1 UBE2B UBE2A UBE2G2 UBE2T UBE2W WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 AP2A1 FZD5 AP2S1 AP2A2 ROR1 ROR2 CLTC CLTA AP2M1 AP2B1 CLTB WNT5A ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 VWF ADAMTS13 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport OXA1L COX7B COX7C COX8A COX8C COX5B COX5A COX6C HIGD1A COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C COX19 UQCRB COX17 UQCC3 UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH LYRM4 CMC1 UQCRQ PYURF LYRM7 SCO1 UQCRC1 TMEM126A UQCRFS1 UQCRC2 CYC1 GOT1 TMEM126B MT-CYB TRAP1 FXN SURF1 NDUFS3 GOT2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 COX15 NDUFAF5 TIMM21 SLC25A18 NDUFAF2 NDUFB8 MDH1 SFXN4 MDH2 NDUFAF3 SLC25A12 MT-ND6 CYCS NDUFAF1 SLC25A11 HCCS SLC25A22 MT-ND4 TMEM186 SLC25A13 MT-ND5 MT-ND2 RAB5IF MT-ND3 ACAD9 MT-ND1 COQ10B COX7A2L COQ10A TMEM177 NDUFA5 DMAC1 DMAC2 PET117 ECSIT TIMMDC1 PET100 LETM1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 SDHC HSPA9 SDHD SDHA SDHB NDUFB10 COX16 NDUFB11 COX18 COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 COXFA4 HIGD2A COX20 COX7A2 ETFA COX7A1 TMEM223 COA5 NDUFC2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 COX4I1 COX4I2 ETFB MT-CO1 NDUFAB1 SCO2 MT-CO2 MT-CO3 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 MAML2 MAML1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 FLT4 PSMA7 ACTA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSENEN PSMB2 PSEN2 PSMB3 PSEN1 UBC APH1A PSMB1 NCSTN RPS27A APH1B ADRM1 HES5 SEM1 NOTCH1 YWHAZ RBX1 NOTCH2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NOTCH4 HEY1 HEY2 SNW1 SMAD3 JAG1 ADAM10 DLL4 KAT2B KAT2A MAMLD1 AKT1 HES1 EP300 RBPJ CREBBP PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TACC3 PSMD1 SKP1 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host HBB HBA2 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP2E1 CYP2F1 CYP24A1 PTGS1 CYP19A1 BPHL CBR3 AADAC AOC3 AOC2 CMBL CYP51A1 MTARC2 MTARC1 CYB5B NQO2 ALDH3A1 EPHX1 FMO2 FMO3 ALDH1A1 CYP11A1 NCOA1 CYP4V2 NCOA2 CYP2R1 NR1H4 CYP7B1 CYP7A1 CYP27A1 FMO1 AOC1 CES2 ADH4 ACSS2 CES3 ALDH2 PTGIS TBXAS1 ALDH1B1 CYP4F12 ADH1C ADH1B CYP8B1 ADH1A ADH7 ACSS1 ADH5 ADH6 ARNT2 POMC PAOX CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 RXRA CYP26A1 CYP26B1 FDX1 CYP26C1 FDXR FDX2 MAOA CES1 HSP90AB1 CYP11B2 ARNT CYP46A1 CYP21A2 CYP39A1 POR CYP2U1 CYP27B1 CYP4F2 CYP11B1 CYP4A11 CYP1B1 AIP MAOB PTGES3 CYB5R3 CYP2J2 CYP3A43 AHR TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EZH2 PHC1 RRM2 BRCA1 PHC3 UXT CHEK1 EPC1 BMI1 RING1 YAF2 RNF2 APAF1 L3MBTL2 MAX EED PCGF6 SUZ12 EHMT2 EHMT1 E2F1 PCGF2 RBBP8 CDC7 E2F6 TFDP1 RBBP4 RYBP TFDP2 RBBP7 MGA RAD51 CBX5 CBX3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis FDX1 HSCB FDXR FDX2 ISCA2 ISCA1 LYRM4 SLC25A28 SLC25A37 GLRX5 FXN ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS OSBPL8 PLA2G4B OSBPL5 PLA2G2A PLA2G4F PLA2G4E OSBPL10 LPCAT4 PLA2G10 PLAAT3 PLA2R1 PLA2G1B LPCAT3 MBOAT1 PLA2G5 PLA2G4A PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA1A PLA2G4D SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis CERS1 CERS2 SAMD8 ORMDL3 SGMS1 PPM1L SGMS2 ORMDL2 CSNK1G2 SPTSSB SPTSSA ORMDL1 CYB5B VAPA DEGS1 VAPB OSBP SPHK1 MFSD2B SPNS2 PRKD3 PRKD2 PRKD1 ABCG2 KDSR FA2H DEGS2 ABCC1 SPTLC1 SPTLC2 SPTLC3 CERS3 CERS4 CERS5 CERS6 SPHK2 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development HDAC3 NCOR1 TBL1XR1 TBL1X CALM1 PRKACA HDAC1 SIN3A CAMK4 GPS2 NCOR2 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins SERPINA1 PPP6C TFG PPP6R1 H2AX PPP6R3 TMED2 CTSC TRAPPC2L MAGT1 LMAN1L F5 F8 TRAPPC6A TBC1D20 USP34 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C H3-3B RAB1A TMED10 H3C8 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 B3GNT3 LMAN2 CD59 SEC31B SEC31A DERL1 ANKRD28 TRAPPC2 DERL2 TRAPPC3 SEC16B H3C15 TRAPPC1 SEC16A TRAPPC10 OS9 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 SUZ12 H2BC9 CNIH3 H2BC8 FOLR1 H2BC5 BET1 H2BC3 STAT3 H2BC1 CTSH TUSC3 H2AB1 H2AC8 H2AC6 H2AC7 EIF5 EIF5B TMEM258 RNF139 UGGT2 VCP UGGT1 MARCHF6 EDEM3 AMFR SEL1L RNF103 TRIM13 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 H2BC26 H2BC21 WDR5 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 RNF5 RBBP5 UQCRQ RBBP7 TCF7L2 UQCRC2 MT-CYB ELOB ELOC TAF10 SARS1 GBA1 ACTB DCAF7 CCT6B TUBB6 ADRB2 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 STARD7 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B TUBA4A FBXW2 XRN2 GAPDHS FKBP9 TP53 ARL2 TBCD TBCC TBCB TBCA CCT6A GNAQ TBCE PDCL FBXL3 FBXL5 TUBA8 WRAP53 TUBA1C XRCC4 TUBA1B TUBA1A KIF13A CCT3 CCT2 BAP1 UBXN1 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 GNA15 TUBA3D TUBA3C GNA11 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR NUP88 RAE1 SUDS3 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 USP10 RPL38 RPL37 RPS11 GSN RPL39 RPS10 MANEA RPS13 RPS12 RPS9 RPL21 RPS7 SFTPC RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 SFTPA2 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 TGFB1 EIF2AK2 OTULIN RPL3L USP17L2 RPS26 RPS25 RPS28 RCE1 RPS29 RPL27A RARS2 RPS20 AARS2 CALR MARS2 PARS2 RPS21 RPS24 DARS2 HARS2 RPS23 YARS2 RPLP1 FARS2 WARS2 RPLP0 GARS1 LARS2 RPS4X RPL7A SARS2 PPA2 RPLP2 NARS2 TARS2 PARP1 RPL13A IARS2 RPS3A VARS2 CARS2 DNAJC3 EARS2 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU PELO RPL26L1 ABCE1 CDC73 ALG14 RNF152 SHPRH ALG13 HLA-B PEX2 RNF40 RNF144A SKIC8 SELENOS WAC CTR9 RTF1 TMEM129 HLTF LEO1 PEX10 PEX12 PEX13 PEX14 VNN1 PAF1 VNN2 RNF181 PROS1 GAS6 LY6E MGAT3 SFTPB RAB27A MYRIP OMA1 U2AF2 OPA1 TTLL10 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 ANO8 AGBL3 TTLL1 AGBL2 TTLL13 TTLL11 TTLL12 TTLL9 TTLL8 LAMB2 FN1 LAMB1 LAMC1 HLA-A B2M RAB2A PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 FOXL2 PSMD10 PSMB11 HIC1 SP3 POMP APEH PSMB10 PSMA8 PSMF1 PSMB8 PSMB9 PSMG3 PSMG4 PSMG1 PSMG2 UBE2D2 CDC34 CDH2 TOMM20 UBE2N TAB1 CHCHD2 LDHD PARK7 CFTR CS TRAF6 ACO2 TIMM17A AXIN2 TIMM22 TIMM9 TIMM10 CSF1 QARS1 RARS1 ACAD8 ACADSB MARS1 MITF DARS1 USP30 LARS1 EEF1E1 HDAC1 PGAP1 LYPD1 KARS1 LYPD2 LYPD3 IARS1 THY1 LYPD4 HADH LYPD5 POMC LYPD8 AIMP1 RHOT1 AIMP2 B3GALNT2 FUCA1 EPRS1 LYPD6B PIGS PIGU PIGT PIGO PROC PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CHST8 IFIH1 CRPPA RNF135 TRIM25 CGA PIGC PIGB TSHB PIGA PTRH2 PIGK PIGM PIGL MAVS PIGG RIGI PIGF ARF5 PIGH ARCN1 RAB5B ETFBKMT LY6K RAB5C POFUT4 POFUT2 POFUT3 RAB5A LY6D LY6H ATXN7 SPRN ETFB FCGR3B SPACA4 MDGA2 RECK MDGA1 KDELR2 GPS1 NRN1 ART3 ART4 SNX3 NTNG1 NTNG2 BST1 GPAA1 OTUD7A MIA2 RNF20 RAB22A CD52 KIN STAMBPL1 NDUFAB1 COPS4 ENGASE OTUD5 COPS2 RXYLT1 PRND EMID1 VCPIP1 CNTN5 HNRNPC UBE2T ALPL CNTN3 CNTN4 ALPG NGLY1 MYSM1 VCPKMT MMRN2 OTUB1 OTUB2 TEX101 GOSR1 FURIN RAB40A RAB40B RAB40C TNIP1 TGFBR1 TNIP3 TGFBR2 GCSH USP17L4 USP17L5 USP17L8 RNF128 ALG10B GPLD1 LIPT2 LIPT1 CHST10 RRAGA GP2 TADA2B ASGR1 PRSS21 ASGR2 EIF4EBP1 COPZ2 COPZ1 WDR20 EIF4E METTL21A EIF4B USP17L3 USP17L1 PRSS41 EEF1AKMT2 EEF1AKMT1 RAB3B RAB3C EIF4G1 RAB3D RAB44 RAB41 RAB42 LARGE2 TECTA TECTB RAB2B USP5 USP3 RAB30 VAMP2 RAB36 STX1A RAB37 APC RAB34 FKBP8 SLC34A2 STAMBP SLC34A1 RAB4B PLET1 CPM PSCA RTN4RL2 BET1L PTP4A2 MVD METTL22 RTN4RL1 RAB20 SEC23A RAB25 RAB26 POMT2 SAR1B RAB23 SEMA5A RAB24 GALNT12 RAB29 SPON2 SEMA5B EEF2KMT FKTN SPON1 THSD7B SLC35A4 FKRP POMT1 ADAMTS4 RAB15 ADAMTSL1 RAB19 RAB17 MBTPS1 ADAMTS5 SEC24B FOLR2 C1GALT1C1 NFU1 SEC24A ADAMTS2 USP17L30 ADAMTS3 YOD1 ADAMTSL5 UMOD ADAMTSL4 LIAS ADAMTS1 OTOA ADAMTSL3 MLEC ADAMTSL2 ZRANB1 MUC12 RAET1G MUC13 RAET1L THSD7A TMED3 SEC24D MUC15 TMED7 SEC24C ADAMTS8 TMED9 LARGE1 IZUMO1R ADAMTS9 CEACAM7 ADAMTS6 NRN1L ADAMTS7 CEACAM5 SBSPON USP17L21 MUCL1 USP17L20 POMGNT1 USP17L22 MUC3A LY6G6C MUC5AC LY6G6D MUC3B USP17L15 ADAMTS20 USP17L18 B3GLCT UBE2L3 USP17L17 CFP USP17L19 LSAMP THBS2 ADAMTS12 USP17L10 THSD1 USP17L12 THSD4 USP17L11 ADAMTS10 USP17L13 ADAMTS16 COPG2 ADAMTS15 COPG1 ALG10 MUC1 ADAMTS14 COPB2 ADAMTS13 COPA MUC2 TRAF2 NTM ADAMTS19 COPB1 ADAMTS18 MAN2A2 ADAMTS17 TMEM115 MUC7 ULBP2 COPE MUC4 MUC6 USP37 GALNT3 USP47 MUC16 USP48 MUC17 USP49 C1GALT1 USP42 MUC19 BIRC2 USP44 PLAUR BIRC3 SSPOP MUC5B POMGNT2 PRKN MUC20 USP16 MUC21 USP12 ABRAXAS2 RIPK1 USP19 OPCML USP24 USP25 USP26 NEGR1 USP20 USP22 USP28 XPNPEP2 POMK MT-ND6 MT-ND4L MT-ND4 OGT MT-ND5 MT-ND2 MT-ND3 MT-ND1 MTRF1 GFM2 MRRF MTRF1L MT-ATP6 ATP5F1A ATP5F1B ATP5MG HSPA9 ATP5PF ATP5PD FFAR4 ATP5F1C MT-ATP8 FFAR1 ATP5PO WDR48 UBE2B CUL4A DDB1 F2 DTL RAD18 GRP CUL4B ASCC2 ASCC3 SFTA3 DMBT1 AGT LMCD1 NAPSA PRKACA CCDC59 ADA2 PGA3 PGA5 PGA4 ADGRF5 ASPH SFTPA1 KNG1 PCCB P2RY2 TXN IGFBP7 OGDH DLST CBX8 HTRA2 PHC2 PHC1 LONP1 CBX4 CBX2 AMER1 KDM8 STS PHC3 OGFOD1 EIF5A ARSA JMJD4 DHPS IL6 FN3KRP MDM2 JMJD7 SUMF2 MDM4 SUMF1 BMI1 JMJD6 TPST2 F7 TPST1 RING1 F9 RCCD1 EIF5A2 PROZ CCNA2 DNAJC24 ARSL CCNA1 DPH1 ARSJ DPH2 RNF2 ARSK DPH3 ARSH ARSI DPH5 ARSF DPH6 ARSG DPH7 ARSD CDKN2A ZC3H15 RWDD1 FN3K ICMT F10 DOHH RIOX1 GGCX RIOX2 DRG1 DRG2 AREG EEF1B2 EEF1G EEF1A1 CPB2 EEF1D EEF1A2 EEF1A1P5 EEF2 ADAM10 NADK2 PPA1 C3 C4A ARFGAP1 ALPI EIF2B5 EIF2B4 EIF2B3 H2BC18 EIF2S3 EIF2B2 EIF2B1 MDH2 EIF2S2 EIF2S1 COP1 BECN1 KLK3 KLK2 IDE ECH1 ACOT2 ST6GALNAC2 PRKCSH ZDHHC2 FUT8 GANAB MAN2A1 MGAT5 CISH ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 SOCS2 GH1 ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C MGAT4A MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 MDC1 MT-CO1 KDELR1 UFD1 SFTPD MT-CO2 MT-CO3 GATA4 GATA3 HNRNPK NPLOC4 ACTL6A DDB2 SEC11A SEC11C BGLAP SPP1 USP9X TOMM70 SPCS3 SPCS2 SPCS1 PDIA3 UBE2D3 LTF YY1 SUCLG2 FH SMC5 SMC6 NDUFA13 DDX17 NSMCE3 NSMCE2 NSMCE1 MRTFA EID3 ZBED1 UBA2 SAE1 TOP2A FOXO4 TOP2B ZNF131 ATXN3 SENP5 SOCS3 SENP2 SAFB NDUFV3 SENP1 NSMCE4A TOP1 NDUFV1 SP100 UHRF2 IDH2 SATB1 CASP8AP2 NOP58 RWDD3 MBD1 IDH3A NDUFS1 NDUFB6 FBXO32 NDUFA2 COX4I1 PTEN SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RABGGTB RABGGTA UBXN7 MUL1 DPP3 TRIM28 L3MBTL2 TGFA APOE SATB2 COX5B COX5A NPM1 NPPA GLUD1 TFAP2B TFAP2C ANKZF1 KLHDC10 TCF25 NEMF ZNF598 CHD3 TRIAP1 AURKA INS SNCA TARS1 AARS1 HARS1 FARSA FARSB MALSU1 TUBB8 MIEF1 MTFMT YARS1 TUBB8B NARS1 CARS1 VARS1 MTIF2 GGA2 MTIF3 WARS1 GGA1 MTRFR GGA3 MTRES1 PRELID1 RAB8B RAB4A RAB33A RAB33B RAB11B RAB35 RAB7B CHM ING2 NCOR2 KAT2B KAT2A IGF2 IGF1 ZNF350 SYVN1 PCGF2 HIPK2 KDM1B MEN1 IGFBP1 USP7 IGFBP3 USP2 ADORA2A LHB PENK SIN3A FSHB HDAC2 HDAC7 KLF4 PML SEC61A2 SEC61A1 SEC61G SEC61B KCTD6 CAPZB SMAD2 SMAD1 SMAD4 SMAD3 CBX5 SMURF2 CAPZA1 CAPZA2 TIMP1 SMAD7 INHBA ARG2 CGB8 INHA AXIN1 USP15 LTBP1 THBS1 HSPD1 UCHL5 USP8 TTF1 ARRB1 ARRB2 FGA FGG NEDD8 CAND1 CP TF DBT DLD COL7A1 DCAF13 PCSK9 APOA2 APOA4 APOA5 CD109 RAB27B CALU GPIHBP1 QSOX1 ALB AHSG P4HB SPP2 APLP2 SCG3 HSPG2 SDC2 MMRN1 PLG ST3GAL6 B4GALNT2 UCHL1 SENP8 UCHL3 B4GAT1 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 B3GNT7 B3GNT4 B3GNT2 GPC3 SLC17A5 GOLGB1 ALG11 PDIA6 KDELR3 DCTN1 SSR1 FUT3 WFS1 EDEM1 SRPRA SRPRB B4GALT2 B4GALT3 B4GALT1 HK1 OXSM B4GALT6 CLPX CLPP ALDH18A1 PCMT1 MSRA MSRB2 B4GALT4 MSRB3 B4GALT5 ST6GALNAC6 MSRB1 TRAF3 IKBKE ALDH2 ALDH1B1 ATXN3L MTA1 JOSD2 JOSD1 TOPORS TNFAIP3 OTUD7B USP21 USP4 CYLD GALNT1 TDG CSF2RB CSF2RA MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 GALNT11 MRPS12 GALNT14 MRPL38 GALNT13 MRPS10 GALNT16 MRPL39 GALNT15 MRPL36 GALNT18 MRPL37 GALNT17 MRPL34 GALNT10 MRPL35 GALNT9 MRPL32 GALNT8 MRPL33 B3GNT9 QTGAL MRPL41 MRPL4 B3GNT8 MRPL42 B3GNT6 MRPL3 B3GNT5 CHST4 MRPL2 MRPL40 GCNT1 MRPL1 GCNT3 MRPL9 GCNT4 GCNT7 CHCHD1 MRPS28 GALNT7 GALNT6 TSFM MRPS26 GALNT5 MRPS27 GALNT4 MRPS24 GALNT2 MRPS25 A4GNT MRPS22 GALNTL5 MRPS23 GALNTL6 MRPL49 MRPS18B MRPS18A SPG7 MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 AFG3L2 MRPL46 SMDT1 MRPS6 VDAC3 MRPS5 VDAC2 MRPL43 YME1L1 MRPL44 TUFM PMPCA MRPS18C MRPL52 VDAC1 MICU2 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 RHOA BMP4 RAB10 RAB14 RAB13 ARFGAP3 NDUFS3 RAB7A MGAT5B SHMT2 LMAN1 STX5 YKT6 KTN1 STAR TNC GMPPB PMM1 GMPPA PMM2 MPI FBN1 ABCA3 DAG1 ISL1 GSPT2 LEP GSPT1 DPAGT1 ALG8 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 PABPC1 GATA6 CUL2 USP33 ETF1 HSD17B10 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 MMP2 ST6GAL2 SLC35C1 ALG5 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA NUS1 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ACE2 VGF DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 SQSTM1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 ARF1 COMMD8 CTSZ COMMD9 PUM2 HIF3A DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 COMMD7 HSPA8 COMMD4 COMMD5 SPSB3 CCDC8 CUL9 UBD NAE1 HEMK2 SOCS6 WDTC1 SOCS5 CCDC22 COMMD10 TULP4 DCAF16 MAT2B DCAF17 FEM1C TRMT112 DCAF10 DCAF11 FEM1A FEM1B ADRA2C NEURL2 ERCC8 ADRA2A FGF23 LRR1 CCNF PDHB KEAP1 UBE2L6 HERC2 FBXO7 FBXO9 WSB1 DLAT FBXO2 ME2 RNF123 PDK1 PDHA1 UBE2J2 SIAH2 SIAH1 FBXL8 FBXL4 FBXL7 CMA1 TRIM4 SERPINC1 LRRC41 CALB1 NAT8B GAN BACE1 MFGE8 APCS TSPAN33 KLHL2 CST3 TTR UBE2G1 KLHL3 TSPAN5 H2AZ1 UBE2G2 ODAM KLHL9 LYZ SPSB2 SNCAIP SPSB1 SORL1 KBTBD6 TSPAN15 KLHL5 TSPAN14 NAT8 SEMG1 KBTBD8 TGFBI SPSB4 ITM2B FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PCSK2 PCSK1 ERO1B FBXW12 KIF5C ANPEP FBXW8 KIF5B UBE2E3 KIF5A FBXO17 CPA3 SLC30A8 FBXO15 MME SLC30A5 ATP6AP2 LMO7 FBXO10 CES1 FBXO11 ENPEP CPB1 KLHL41 GPR119 KCTD7 PLA2G7 CRHR2 KLHL42 DPP4 UBE2V2 CLTRN ACE CUL7 CUL5 CDX2 INHBB UBA6 MBOAT4 INHBC INHBE GZMH KLHL11 CPE REN KLHL13 FBXO44 FBXO41 FBXO40 TFAM BTBD1 UBE2F UBE2H KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBA3 ARF3 UBA1 UBE2K UBE2M KBTBD13 UBE2Q2 UBE2R2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 VHL FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 FSTL1 CHRDL1 ASB4 ASB5 ASB2 ASB3 ASB1 CTBP1 CKAP4 DNMT3B DNMT3A DNMT1 PSENEN APH1A NCSTN APH1B IL33 MMP1 POLB GNAT3 MYO5A CTSG ARFGAP2 NLRP3 ADORA2B TRIM27 USP13 TNKS TNKS2 RNF146 OTUD3 MAN1A2 MAN1C1 MAN1A1 ECI1 RAB32 RAB31 RAB38 NSF RAB21 GRIA1 CHML RAB39A RAB39B RAB12 RAB18 TADA3 PNPLA2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 ALAS1 FBXW11 PSMA5 FECH PSMA6 PSMA3 PAX6 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 BCL10 RIPK2 DCTN5 PSMA7 DCTN4 RELA CAPZA3 PSMB6 ACTR10 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 USP14 NOD1 PIAS4 NOD2 HDAC4 PIAS3 USP18 THRB UBE2I VDR NR1H2 RORA NR3C1 TNIP2 SAA1 NR2C1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA BRCA1 CCP110 CSNK1D BLM PCNA WRN BARD1 RPA1 PALB2 ARF4 UBE2C CETN2 UBE2E1 UBE2D1 ACTR1A UBE2S CDK1 STAM RAB8A HGS CTNNB1 EXOC8 STAM2 EXOC7 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 DCTN2 DCTN3 GBF1 HDAC3 RAB11A NRIP1 EP300 APOB PPARGC1A NCOA1 NCOA2 CREBBP APOA1 NFE2L2 RAB43 COG8 COG7 COG6 COG5 COG4 COG3 CALM1 COG2 COG1 APP NAPA NAPB CDC25A NAPG GOLGA2 TGOLN2 RAB6A RAB6B RAB9A RAB9B RBX1 UCN GNGT1 GNGT2 GIP IAPP CALCA GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CD55 DDX5 GCG CTSD GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 ANK2 CUL3 ANK3 ANK1 KBTBD7 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 VCAN GLB1 ARSB CDKN1A SPTAN1 CAMKMT SPTB SKP2 DAXX CCNE2 CCNE1 NUP107 SMC3 CDC20 DYNC1LI1 DYNC1LI2 CDCA8 ACHE NUP160 NUP85 RAD21 BCHE RAB3A STAG1 STAG2 RPS27 SEC13 NUP133 DYNLL1 SMC1A RUVBL1 RANGAP1 NFRKB DYNLL2 ACTR5 INCENP RAD23A BIRC5 ACTR8 RAD23B INO80C INO80B INO80E DYNC1I2 INO80D COPS7B AURKB COPS7A XPC TFPT MCRS1 NUP43 INO80 COPS3 COPS6 DYNC1I1 COPS8 RANBP2 DYNC1H1 BDH1 OXCT1 HMGCS2 ACAT1 NUP37 PRL TWNK SSBP1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B BRCC3 CLSPN TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 DMP1 LGALS1 EVA1A RAD52 CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 H2AC17 PAPPA MXRA8 H2AC12 SPARCL1 IGFALS FDX1 PRMT3 H2AC1 SCG2 KLK1 H2AC19 H2AC25 STC2 H2AC14 H2AC21 IGFBP6 H2BC12L AMELX AMBN TMEM132A MYC FUCA2 BPIFB2 HRC MELTF HSP90B1 SERPINA10 CSNK2A1 MIA3 MSLN CSNK2A2 PRSS23 BMP15 CSNK2B MEPE RCN1 ENAM RPN2 EPAS1 AMTN FAM20C VWA1 RPN1 FAM20A MATN3 PAPPA2 ITIH2 HIF1A AFP FSTL3 APOL1 SERPIND1 GOLM1 KLK13 NUCB1 NOTUM H4C9 PRKDC TRRAP H2AC20 MCFD2 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNA2D1 CACNA1B CACNG4 CACNA1A CACNA2D3 CACNA1E CACNA2D2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives PTGS2 GPX1 ALOX15 GPX4 ALOX15B GPX2 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency NAGS UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins FURIN MAP2K4 CALM1 MAP2K1 MAP2K2 PDCD6IP MAP2K7 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins POM121C PHC2 NUP42 NUP62 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 PHC3 CETN2 NDC1 NUP210 NUP155 TRIM28 NUP153 NUP93 MDM2 NUP50 NUP35 NUP54 BMI1 RING1 RNF2 HNRNPK FOXL2 HIC1 L3MBTL2 SP3 CDKN2A VHL SUZ12 DAXX NUP107 SMC3 SATB2 NPM1 CDCA8 NFKB2 NUP160 NUP85 RAD21 SIN3A EIF2AK2 STAG1 CTBP1 STAG2 NRIP1 EP300 SEC13 PPARGC1A TFAP2B NCOA1 NUP133 TFAP2C NCOA2 CREBBP HDAC2 SMC1A RANGAP1 PARK7 PARP1 INCENP HDAC7 BIRC5 CHD3 IKBKG AURKB XPC PML AURKA NUP43 HERC2 RANBP2 DNMT3B DNMT3A DNMT1 RELA IKBKE SMC5 SMC6 NUP37 DDX17 NSMCE3 NSMCE2 MITF NSMCE1 NFKBIA MRTFA EID3 ZBED1 TOP2A TOP2B ZNF131 MTA1 HDAC1 SAFB PIAS4 NSMCE4A HDAC4 PIAS3 TOP1 THRB SP100 UBE2I TOPORS UHRF2 VDR SATB1 CASP8AP2 NR1H2 RORA NOP58 NR3C1 NR2C1 MBD1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR CBX5 RXRA SUMO1 TP53BP1 SUMO3 SUMO2 RARA PGR RNF168 PPARG PPARA ING2 BRCA1 RAD52 TP53 NCOR2 XRCC4 ZNF350 MDC1 TDG BLM PCNA WRN PCGF2 DDX5 HIPK2 H4C9 HNRNPC RPA1 NUP205 POM121 NUP188 TRIM27 AAAS CBX8 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria CASP8 GZMB NMT1 BID SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism PSPH SRR SDS PHGDH SDSL SERINC1 PSAT1 SERINC3 SERINC2 SERINC5 SERINC4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression MLX ACACA ACLY FASN AGPAT1 MLXIPL ACACB INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling IL20RA IL20RB IL22RA2 IL22RA1 JAK3 IL10RB IFNLR1 IFNL1 TYK2 JAK1 STAT2 IL22 IL20 IL26 IL24 STAT5A STAT5B IL19 JAK2 STAT1 STAT4 STAT3 IFNL2 IFNL3 PTPN11 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes SOD3 HMOX1 ATF4 EP300 NQO1 GSTA3 CREBBP GCLC GCLM SRXN1 CHD6 GSTA1 MAFK PRDX1 SLC7A11 BACH1 NFE2L2 TXN TXNRD1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH1 NOTCH2 NOTCH3 NOTCH4 POGLUT1 POFUT1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression EZH2 H2AX ASH2L ZNF610 SMARCB1 CCNC TRIM28 H3-3B SMARCC1 SMARCC2 H3C8 MYBBP1A H2AJ ERCC6 H3C15 ZNF708 SUZ12 H2BC9 H2BC8 H2BC5 AGPAT2 H2BC3 SMARCA2 SMARCA4 H2BC1 MPHOSPH8 MBD2 H2AB1 H2AC8 H2AC6 H2AC7 ZNF765 ZNF93 ZNF816 ZNF534 KMT2A KMT2C ADIPOQ HDAC3 SMARCD3 GSK3B DPY30 H2BC26 H2BC21 MTREX WDR5 EP300 PIWIL4 EED TBL1X H2BC17 H2BC12 PPARGC1A H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 CREBBP POLR1C NCOA6 H2BC11 POLR1D SIRT1 RRP8 NCOR1 TBL1XR1 PLIN2 CHD4 RBBP4 CHD3 RBBP5 RBBP7 H2AZ2 DDX21 MTA2 PHF20 DNMT3B DNMT3A DNMT1 CDK5 TBP ANGPTL4 MED4 MED6 MED7 LPL LIPE HDAC1 DGAT2 ZNF141 ZNF382 SETD1B SETD1A UHRF1 ACTB FABP4 KDM6A ZNF136 TET3 PLIN1 LPIN1 MGLL NCOR2 KAT2B KAT2A PAXIP1 SMARCA5 GPS2 BAZ1B HCFC1 NCOA3 NR5A2 ZNF33A ZNF331 ARID4B ZNF28 PSIP1 ZNF273 SAP30 SUDS3 ZNF324 DNMT3L SPOCD1 PPARGC1B MEN1 C19orf84 ZNF264 ZNF320 SAP30L SAP18 ZNF30 ZNF317 ZNF257 MED16 RB1 MED17 MED12 MED14 SF3B1 MED13 MED10 ABL1 CXXC1 ZNF547 ACTL6A MED27 MED23 MED24 MED20 CDK8 ZNF778 GPAM SCD KAT8 PHLDA1 ACSL1 HCFC2 ZNF224 WDR82 SIN3B PEX11A MBD3 BOD1L1 SIN3A MBIP TASP1 KAT14 DR1 BOD1 CIDEC TADA2A ZZZ3 GATAD2B GATAD2A YEATS2 TADA3 ZNF519 AKAP8L SGF29 ELOVL5 PHF20L1 PLIN4 SMARCD1 KANSL1 EZH1 HDAC2 KANSL2 PHF19 SMARCD2 KANSL3 EPOP THRSP PHF1 PNPLA2 JARID2 TET2 ZNF454 TET1 MTF2 EZHIP CEBPA ZCCHC8 SMARCE1 MCRS1 RBM7 TASOR PDK4 PPHLN1 OGT ACSS3 ZNF680 KMT2D KMT2B MORC2 ZNF354A MTA1 MED30 MTA3 MED31 UBE2I ZNF669 CCNH ZNF425 CBX5 POLR2E RXRA POLR2F CBX3 POLR2H SUMO2 BCL7A POLR2K BCL7C POLR2L DPF1 CD36 GTF2H1 BCL7B DPF2 GTF2H2 DPF3 SS18 GTF2H3 SS18L1 GTF2H4 ZNF418 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 SUV39H1 ARID1A ARID1B H2AC19 H2AC14 H2BC12L ZNF649 ATF7IP SETDB1 AEBP2 TTF1 SAP130 UBTF DEK SAP30BP TDG POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H BAZ2A EHMT2 TAF1D EHMT1 TAF1B PAGR1 TAF1C TAF1A H4C9 AJUBA H2AC20 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R SOS1 THEM4 IGF1R KLB IRS1 PDE3B AKT2 PIK3R4 IRS4 IRS2 IGF2 FGF1 IGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs FURIN PCSK6 PCSK5 RAC1 FOS NAB1 NAB2 SH3GL3 ARC TRIB1 TPH1 SRC RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 MAPK7 LYL1 F3 SH3GL2 VGF ELK1 ASCL1 RALA CDK5R2 SHC2 RALB SHC3 DNM1 SHC1 DNM3 YWHAB NTRK2 CRKL DOCK3 BDNF ADORA2A NRAS RAP1A GAB1 FRS3 MAPK1 STAT3 GRIN2B HRAS RALGDS NTF4 TIAM1 MAPK3 NTF3 NTRK1 MAP2K1 PLCG1 FOSB MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 DNM2 RIT2 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 RAPGEF1 SOS1 CRK ATF2 PTPRS PTPRO IRS1 IRS2 RHOA PIK3CB RPS6KA5 EP300 ID4 EGR1 MEF2D CLTC PIK3CA PPP2R5D MEF2C CLTA CHD4 PTPN11 PPP2CA PPP2CB AP2A1 AP2A2 REST BAX AP2M1 NELFB JUNB CDK5 RPS6KA1 ATF1 CDK5R1 MEF2A DUSP4 DUSP3 NTRK3 VRK3 DUSP6 DUSP7 SGK1 AP2S1 AP2B1 ID1 ADCYAP1 ADCYAP1R1 EGR2 TCF12 PIK3R2 SRF PIK3R1 RPS6KA3 RPS6KA2 JUND NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC AKT1 PSMB1 RPS27A ADRM1 SEM1 YWHAZ RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NOTCH4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TACC3 PSMD1 SKP1 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation RPS6KA3 RPS6KA2 MAPK1 PDPK1 RPS6KA1 MAPK3 RPS6KA6 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling PTPN6 SOS1 SYK IL2RG INPPL1 JAK3 HAVCR2 INPP5D JAK1 IL21R LGALS9 IL15RA PIK3CD IL21 PIK3CB STAT5A IL15 STAT5B GAB2 GRB2 PIK3R3 PIK3R2 PIK3R1 PIK3CA IL9 SHC1 JAK2 LCK IL9R IL2 STAT1 IL3 STAT4 STAT3 SOS2 PTK2B IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CSF2 IL2RA LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival FURIN CD3G IL6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 ADAM17 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 PRKACG IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK GNGT1 GNGT2 GNAT3 AHCYL1 ADCY9 PRKAR1B PRKAR2B PLCG2 PRKACA SYK GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 IGHG3 GNG7 IGHG4 PRKAR1A GNG8 IGHG1 CYSLTR1 IGHG2 IL10 CYSLTR2 CD163 GGT1 PLK2 DPEP2 RHBDF2 DPEP1 MYH9 GNAZ GGT5 FCGR3A LYN FGR YES1 GNG12 ADORA2B GNG11 FCGR1A GNG13 GNB2 GNB1 FCGR2A GNAS GNB4 GNB3 GNB5 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors LIN7A LIN7C LIN7B GRIN3B GRIN3A NBEA CAMK2B CAMK2D ACTN2 CAMK2A KIF17 GRIN2C GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 NEFL CAMK2G GRIN2B CASK APBA1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 SOS1 FGF18 PIK3R1 PIK3CA FGF10 NRAS GAB1 FRS3 HRAS PLCG1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FGF7 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein GSK3A PARP6 UBE2I PARP4 PARP16 PARP9 PARP14 PARP8 PARP10 GSK3B SUMO1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation B4GALT6 ST6GAL1 MGAT4C B4GALT4 B4GALT2 MGAT4A B4GALT5 B4GALT3 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 ST8SIA3 MGAT5 ST3GAL4 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology EZH2 H2AX ASH2L RAC1 TEAD1 TEAD2 H3-3B TEAD4 H3C8 FOS SRY H2AJ ATP6V1E1 YAP1 ATP6V0B ATP6V1G1 ATP6V0E1 H3C15 PAK1 ATP6V1B2 ATP6V0D1 ATP6V0C PAK3 PAK2 SUZ12 H2BC9 ATP6V1A H2BC8 H2BC5 H2BC3 STAT3 ATP6V1H H2BC1 ATP6V1C1 NR2F2 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 STT3B GSK3B PIK3CD DPY30 PIK3CB H2BC26 H2BC21 ARHGEF11 ARHGEF12 WDR5 YWHAG EED RHOB H2BC17 H2BC12 H2BC13 H2BC14 POU2F2 H2BC15 PIK3CA ARHGEF28 COL4A2 H2BC11 COL4A1 COL6A2 JUP LEF1 COL4A4 CDC42 COL6A1 RBBP4 COL4A3 RBBP5 FYN COL9A1 DIAPH1 RBBP7 COL6A3 TCF7L2 H2AZ2 TCF7L1 PTPN11 KRT4 COL4A5 COL9A3 KRT3 TNRC6C KRT2 COL6A6 COL9A2 KRTAP17-1 KRT8 COL6A5 KRT7 TNRC6A KRT5 AP2A1 TNRC6B KRT9 RHOC KRTAP4-11 AP2A2 KRTAP20-1 KRTAP20-2 ARHGEF7 TNF KRTAP10-10 PRKACG NGEF KRTAP10-11 KRTAP10-12 KRTAP27-1 PRKACB ELOB KRT33B KRTAP5-10 AP2M1 ELOC KRT33A KRTAP5-11 KRTAP16-1 KRTAP8-1 KRTAP26-1 KRT24 NCBP1 KRT23 NCBP2 KRT20 KRT28 PLXNB1 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 ANGPTL4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 LPL KRTAP9-2 KRTAP9-1 AP2S1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 KRTAP25-1 KRTAP2-4 AP2B1 KRTAP2-3 KRTAP2-2 KRTAP2-1 ACTB KRT13 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 LEFTY2 KRT14 KRTAP24-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 CFL1 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 TP53 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRTAP23-1 GPR143 KRT40 KRTAP4-4 SDC2 KRTAP4-3 KRTAP4-2 KRTAP4-1 PAXIP1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 EYA1 KRTAP11-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 CTNNA1 GRB7 KRTAP19-1 KRTAP19-4 FOXF1 KRTAP19-3 RND1 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 SNAI1 PLXNA1 KRT82 PLXND1 KRT81 KRTAP21-2 KRT80 KRTAP21-3 PBX1 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 PKP4 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 GPC1 AGRN RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 DMRT1 ZFPM2 RPL35 PTGDS RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA FGFR1 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 TGFB1 RPL3L RPS26 RPS25 RPS28 RPS29 KLF13 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X MESP1 RPL7A RPLP2 TBX20 SMYD1 HSP90AA1 TBX1 MYOCD RPL13A HAND1 RPS3A GDF1 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ARHGAP39 SLIT2 SEMA4D SRGAP3 LIMK2 SRGAP2 LIMK1 FOXH1 RRAS SRGAP1 DRAP1 CBFB ROBO1 MYH14 MYH10 RUNX1 UCP1 HNRNPU MTA1 PRDM16 ZNF423 MTA3 ELOVL3 CIDEA EIF4A3 EBF2 CASC3 BMP7 MAGOH GMPR PMEL BCL7A MLANA BCL7C DPF1 BCL7B DPF2 DPF3 SS18 RBM8A SS18L1 RAB27A MYRIP PRKCA SYTL2 MLPH IRF4 UPF3B MAGOHB RNPS1 SOX2 ZEB2 FGF8 SOX1 GBX2 OTX2 TBX6 BTG4 POU3F1 ZFP36L2 ZNF521 PABPN1L DICER1 PITPNA TRPM1 TRPC7 STAT4 TRPC5 TRPC6 IL12RB2 TRPC3 TRPC4 TRPC1 IL5 LAMA5 LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN TCHH TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ CDON LIPN LIPM PRSS8 LIPK TGM5 RPTN CELA2A SPINK6 SPINK5 KAZN LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A IL4 LCE6A PKP2 LORICRIN IL13 SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 FLG PRKCQ SPRR2E SPRR2F SPRR3 SPRR2G CSTA KLK5 EVPL FOXC2 FOXC1 PPL KLK8 SIX1 PCDH19 LCE2D HOXD11 LCE3C HOXC11 ADIPOQ LCE3D WFDC2 LCE3A LCE3B HOXA11 GXYLT2 LELP1 PLAC8 SALL1 CDH2 PI3 SPRR2A PXN SIX2 HOXA6 TERT SPRR2B EDIL3 IRX1 SPRR2D ST14 IRX2 CEACAM1 EMX2 ZEB1 CDSN RHOA PXDN KLK14 OSR1 BIRC7 LCE3E GFRA1 KLK12 NPNT ASAH1 POU3F3 BCL2A1 LCE4A TBX2 PAX2 SPRR1A BMP4 SPRR1B GREM1 RPS6KA5 GDNF PAX8 LHX1 ID4 ITGB1 HOXB4 DIS3L2 TRIO ITSN1 SLC2A4 ARHGAP35 LEFTY1 ACVR1C CRIPTO3 CRIPTO ACVR1B ACVR2B CFC1 CER1 NODAL DAND5 ZIC3 DOCK1 SALL4 NANOG EPHA1 EPHA2 POU5F1 KALRN CSF1 MC4R HINT1 EDNRB UNC5A PAK4 QARS1 ZIC1 RPS6KA1 UNC5B TNFSF11 SOX9 YWHAH FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB PAX3 MITF POU3F2 YWHAZ SOX10 DARS1 MC3R LARS1 KIT TFEC EEF1E1 HDAC1 KARS1 ALX3 IARS1 MARK3 TBX3 POMC AIMP1 KDM5A UHRF1 AIMP2 FABP4 MC1R KDM6A EPRS1 STPG4 AICDA ID1 MC5R METTL23 DPPA3 SNAI2 TET3 PLIN1 VAV3 ITGAV PTK2 EBF1 EGR2 DAG1 ADIRF HOXA2 THRAP3 ISL1 ZNF638 SRPK1 PFN1 VAV2 FAM120B ZNF467 PFN2 GSPT2 LEP GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH HSP90AB1 PABPC1 EOMES GATA6 ROCK1 CXCR4 ROCK2 TBXT AKAP5 ZSWIM8 SOX17 PAK6 GSC MIXL1 PAK5 CAP2 MYO9B ACTG1 MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 EPHB6 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 EPHA3 MCM5 EPHA10 MCM2 EFNA5 FURIN EFNA4 PCSK6 EFNB2 EFNB1 EFNB3 EFNA1 EFNA3 EFNA2 ST8SIA4 MAG NAB1 NAB2 EIF4E EIF4B ST8SIA2 EIF4G1 CACNA1H STX1B MYL12A MYL12B CACNA1G CACNA1I MYH11 STX1A SREBF2 CLTB HIF3A MYL6 SEMA5A HSPA8 DNM2 LFNG CYP51A1 DLG1 DLG3 CACNA1C DLG4 IRS2 FGF2 FGF4 FGF7 FGF9 GAB2 ZIC2 FGF10 ITGA2 ITGA1 CSF3R GFI1 IL6R CEBPA CEBPE FLI1 KLF5 SDCBP RELN DAB1 VLDLR SIAH2 SIAH1 FES PRKACA CTCF ETS1 PAGR1 HOXA3 HOXA1 RPS6KA3 PKNOX1 RPS6KA2 HOXA4 PIAS2 HOXB3 HOXB2 HOXB1 AJUBA HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 BMI1 TPST2 KDM6B RING1 PRDM14 LIN28A ZSCAN10 CEBPB RNF2 HIRA MAPK7 CDKN2A GAB1 GRIN2B TIAM1 PLCG1 EGF BCL2 AREG AMH NOG JAG1 ADAM10 DLL1 LGI1 LGI4 CLTCL1 LGI3 LGI2 ADAM22 ADAM11 PIP5K1C ADAM23 SHANK3 GIT1 SLC2A2 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B BATF IL4R MYO5A ARPC1B ARPC1A WASL MED19 MED18 MED11 MED29 MED28 MED22 MED21 GRIN1 MYH9 SPI1 RBPJ ARPC4 ARPC5 ARPC2 ARPC3 MED13L ACTR3 ACTR2 MYO10 MYL9 GATA4 GATA3 GATA2 LIG1 PPARGC1B MMP9 MED9 CDK19 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 CNOT6L ACTL6A MED27 RPS6KA6 MED26 MED23 MED25 MED24 MED20 CEBPD EGFR MBD3 GATAD2B GATAD2A CACNG8 CACNG2 CACNG3 CACNG4 PSMD8 PSMD6 YY1 PSMD7 PSMD2 PSMD3 PSMD1 ONECUT3 ONECUT1 NEUROD1 NKX6-1 NKX2-2 PSMA5 PDX1 PSMA6 PAX4 PSMA3 PAX6 PSMA4 HNF1B PSMA1 HNF1A PSMA2 MAFA RFX6 UBA52 INSM1 PTF1A PSMD12 FOXA3 PSMD11 PSMD14 NEUROG3 FOXA2 PSMD13 MAF PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 DPYSL4 UBB DPYSL5 PSMB2 DPYSL3 PSMB3 UNC5C UBC UNC5D PSMB1 MEF2A AGAP2 RPS27A DSCAML1 KMT2D ADRM1 NFKB1 PLXNC1 SEMA6A SEM1 SEMA6D PSMC5 UTRN PSMC6 DLX5 SEMA7A PSMC3 RAP1GAP PSMC4 PLXNA2 PSMC1 MBP PSMC2 FOXO4 PLXNA3 FOXO1 PTPRC PTPRA PLXNB3 TREM2 MED30 ADGRV1 SEMA3A NTN4 HDAC4 SEMA3E MED31 ABLIM1 UBE2I ABLIM2 SATB1 ABLIM3 SEMA4A ARTN PRX GFRA3 RGMB GFRA2 RGMA NR5A1 GFRA4 DRP2 CD72 RXRA SCD5 SUMO1 MPZ NRTN DSCAM DOK1 RARA DOK2 PPARG TYROBP PPARA DOK4 CD36 DOK5 DOK6 BRCA1 ADGRG6 CACNA1S PRNP KAT5 PSPN HJV CRMP1 HMGCR PDLIM7 PMP22 MECOM HAND2 ITGA5 SRF TBX5 NTN3 CDH4 TRIM33 BNIP2 SMARCB1 CTNNA2 NEO1 CCNC PLK1 SPAG9 MYOG MEF2B MYOD1 CCNB1 MYF6 TCF4 CDH15 MYF5 SMARCC1 SMARCC2 SH3KBP1 SRC CDH1 CTNNB1 MET TGFA SH3GL2 SHC3 SHC1 YWHAB NRAS PCK1 FARP2 MAPK1 WT1 SMARCA2 HRAS SMARCA4 SNW1 MAPK3 MAP2K1 MAP2K2 FRS2 HNF4G MAPK14 MAPK12 HNF4A MAPK11 SOS1 PERP GCK HDAC3 MAMLD1 SMARCD3 CHD9 HELZ2 XPO1 TGS1 EP300 TBL1X MEF2D TFAP2A PPARGC1A TFAP2B NCOA1 TFAP2C MED1 NCOA2 PRM2 CREBBP PRM1 MEF2C NPM2 H1-8 NCOA6 CNOT10 SIRT1 CNOT11 TCF3 NCOR1 TBL1XR1 LDB1 CARM1 CHD4 CHD3 PPP3CB HES7 TBPL2 MESP2 MSGN1 RIPPLY2 NFATC2 PAX7 NFATC1 DLL3 INS NOTO MSX1 MTA2 YWHAE JUN MAML2 MAML1 FOXO3 SERPINE1 CDC25B MYB CDK5 CAPNS1 CAPN1 CDK5R1 MED8 MED4 MED6 MED7 NOTCH1 RBX1 NKX2-5 IHH SHH WNT9B RET RARG IAPP TNKS1BP1 DHH TCF12 NCOR2 KAT2B KAT2A TAL1 RARB WNT11 TUT7 WNT1 KDM4E TUT4 TPRX1 DUX4 WNT4 LEUTX STAT5A WNT10B TPRXL STAT5B DPPA4 TPRX2 DPPA2 ZSCAN4 DUXA DUXB WNT3A FOXA1 PAIP1 KRT1 PCGF2 POU2F1 NCOA3 USF1 RPS6KA4 ALCAM ITGA2B SCN11A DPYSL2 SCN9A NRCAM EPHB2 SCN1B RASA1 SCN1A ANK2 ANK3 ANK1 SHTN1 MEN1 SCN10A SCN8A KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 NCAN SPTA1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN L1CAM KIF4B KIF4A ITGA10 CNTN1 CNTN2 CD24 SCN2A NOTCH2 SCN2B NRP2 CNTNAP1 CHL1 SCN5A CDKN1A SPTAN1 LYPLA2 CCND3 SPTB DNM1 CCND1 DNM3 E2F1 GAP43 DCX ABL1 NUMB SCN4A SCN4B ITGA9 SCN7A CCL3 TFDP1 NCAM1 RANBP9 TFDP2 NFASC CDK4 CDK2 PLXNA4 CNOT4 CDK8 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 SIN3A RPS27 CACNB1 CACNB2 CACNB3 CACNB4 HDAC5 SMARCD1 HDAC2 SMARCD2 HDAC8 HDAC9 HDAC6 HDAC7 SMARCE1 KLF4 CLASP1 HDAC10 CLASP2 HDAC11 RUNX3 DCT TYRP1 TYR PRL EIF4A2 EIF4A1 DSP DSG1 TBX21 PKP1 DSG2 DSG3 COX7A1 POLR2A SMAD2 CACNA1D POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L ACVR2A KDM5B ARID1A ARID1B H2AC19 H2AC14 IFNG H2BC12L AKT2 MYC AKT3 AKT1 ERBB2 HES1 CSNK2A1 CSNK2A2 ITGA8 CSNK2B DEK ITGB3 EPAS1 PIK3R3 PIK3R2 PIK3R1 GRB10 LYN WWTR1 KLK13 YES1 H4C9 TLN1 MOV10 AGO3 STAT6 AGO4 H2AC20 AGO1 AGO2 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs MYH9 RHOB PAK1 RHOC MYL12B CFL1 PPP1CB PPP1R12A PPP1R12B MYH11 LIMK2 LIMK1 MYH14 MYH10 MYL6 RHOA ROCK1 MYL9 ROCK2 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm RIPPLY2 DLL3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAML2 MAML1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 SEM1 NOTCH1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SNW1 NOG LFNG DLL1 FGFR1 KAT2B KAT2A MAMLD1 TBXT TBX6 BMP4 EP300 RBPJ WNT3A CREBBP LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 EPHA4 PSMD1 HES7 MESP2 MSGN1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription CDK8 HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 NBEA CUL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 UBB MYC UBC HES1 RPS27A HES5 HEYL NOTCH1 EP300 RBX1 TBL1X RBPJ HDAC5 HDAC1 HDAC2 HIF1A CREBBP HEY1 TLE4 HDAC4 TLE2 HDAC8 HEY2 HDAC9 HDAC6 NCOR1 HDAC7 TBL1XR1 SNW1 TLE1 SKP1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle RNF139 UGGT2 VCP UGGT1 MARCHF6 EDEM3 EDEM2 SEL1L AMFR MOGS RNF103 UBA52 TRIM13 MLEC MAN1B1 RNF185 UBB UBC RPS27A UBXN1 DERL1 DERL2 CALR OS9 PSMC1 SYVN1 PDIA3 ENGASE RNF5 PRKCSH EDEM1 CANX RAD23B NGLY1 GANAB HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes ATM ATR CCNK CCNT2 ELL CCNT1 JUN ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H FOS CTDP1 SUPT4H1 MSH2 PMS2 ELOA2 SSRP1 MLH1 CDK9 TCEA1 FANCD2 CCNH CDK12 CDK13 POLR2A POLR2B POLR2C POLR2D FANCI POLR2E DDB2 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K FANCC POLR2L GTF2H1 GTF2H2 BRCA1 SUPT5H GTF2H3 GTF2F1 GTF2F2 TP53 GTF2H4 GTF2H5 CDK7 CHEK1 ERCC3 ATF2 ERCC2 MNAT1 RAD51D MDC1 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport SLC5A2 SLC2A6 SLC2A7 SLC2A3 FGF21 SLC2A4 SLC50A1 SLC2A8 SLC5A9 SLC60A2 SLC2A10 SLC2A1 SLC5A4 SLC2A9 SLC45A3 SLC2A14 SLC2A11 SLC2A12 SLC2A2 SLC5A1 SLC5A10 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 SFTA3 CSF2RB SFTPC SFTPD CSF2RA SFTPB SFTPA1 SFTPA2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS2 EIF2S3 EIF2S2 EIF2S1 FAU RPS27A EIF1AX EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment CHUK UBE2N UBE2V1 UBA52 RIPK3 UBE2D1 UBE2D2 UBE2D3 TICAM1 IKBKB BIRC2 UBB TRAF6 BIRC3 TLR3 UBC RIPK1 IKBKG RPS27A OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 UBE2D1 PSMD12 ELOB PSMD11 PSMD14 ELOC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 VHL UBE2D2 HIF3A LIMD1 EGLN1 EGLN3 EGLN2 WTIP CUL2 EPAS1 HIF1A UBE2D3 PSMD8 PSMD6 AJUBA PSMD7 PSMD2 PSMD3 PSMD1 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria PPP1R13B TFDP1 TP53BP2 TFDP2 TP73 TP63 BBC3 TP53 E2F1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs ALOX5 PTGS2 ALOX15 ALOX12 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants KIT LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation GRIA1 CALM1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B NRGN GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 SRC NEFL NRG1 GRIA2 CAMK2G METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes AHCY TPMT MAT1A OPLAH CYP26B1 CYP26C1 FDX1 FDXR FDX2 MAOA CYP24A1 FMO3 GSS TBXAS1 GGT1 ACY1 CYP11B2 SLC35D1 CYP21A2 CYP27B1 CYP2U1 CYP11B1 CYP11A1 CYP1B1 UGT1A1 GCLC CYP2R1 GCLM UGT1A4 CYP7B1 CYP27A1 CYP4F22 CYP17A1 CYP19A1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP2U1 CYP4F2 CYP4F3 CYP2W1 CYP4A11 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP2D6 CYP2S1 CYP3A43 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants ALK SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins MET ITGB1 HGF TNS4 TNS3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding CALM1 PLCB3 PLCB1 PLCB2 GNG10 GNG3 GNG2 DLG1 DLG3 GNG5 DLG4 GRIK5 GNG4 GRIK3 GNG7 GRIK4 GNG8 GRIK1 GRIK2 NCALD GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling SOCS2 SOS1 SOCS6 SYK UBA52 FOXO3 BCL2L11 AKT2 UBB AKT3 UBC AKT1 RPS27A CBL STAT5A STAT5B HCK SH2B3 GAB2 ABL2 FLT3LG CDKN1B PIK3R1 PIK3CA LCK GRB10 NRAS HRAS SLA2 SLA FYN CSK PTPRJ FLT3 GRAP2 PTPN11 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PLA2G4A PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 MAPK1 PRKCG KPNA2 ADCY9 PRKAR1B IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand DNA2 PCNA LIG1 POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RPA1 RPA2 RPA3 FEN1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing SNU13 SNW1 SNRPD2 SNRPD1 SNRPD3 TCERG1 SNRPG SNRPC SRSF8 SNRPA HTATSF1 SNRPE RBM25 SNRPF SNRNP70 PRPF40A SNRPB PPP1R8 SRSF10 SRSF12 MTREX RBM39 PPIL2 NCBP1 NCBP2 PQBP1 SRRT LSM5 LSM4 LSM3 ZCRB1 SNRNP200 LSM2 LSM7 FUS LSM6 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA3 TRA2B GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC DHX16 RBMX HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 SAP18 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD STEEP1 SF3B4 GPATCH1 SF3B5 PNN SF3B2 SF1 SF3B3 DHX8 SF3B6 PRKRIP1 SF3B1 CWF19L2 SF3A3 WDR70 SF3A1 DHX35 SF3A2 PRPF38A XAB2 SMU1 PHF5A NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A TXNL4A CACTIN SNRPN PRPF31 RBMX2 CHERP SNIP1 IK PRP4K LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 PTBP1 YJU2 PLRG1 LSM8 SNRPA1 PPWD1 DNAJC8 USP39 SART1 PUF60 TFIP11 SNRPB2 SYF2 C9orf78 LUC7L3 PPIL1 NSRP1 SNRNP40 WBP4 RNF113A MFAP1 RBM42 BUD13 PPIL3 PPIL4 FAM50A SRRM2 AQR CRNKL1 PDCD7 SNRNP35 PRPF19 SNRNP25 RNPC3 ZMAT5 ZRSR2 SNRNP48 HNRNPH1 HNRNPH2 CWC25 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 RBM7 HNRNPU EIF4A3 CASC3 MAGOH CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D DDX39B POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 GTF2F1 RBM8A GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ACIN1 ALYREF UPF3B MAGOHB RNPS1 DDX41 ZNF830 DHX9 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome TGFA PAG1 EREG PIK3R1 BTC PIK3CA EPGN HBEGF EGFR GAB1 PXN EGF CSK AREG SRC PTPN11 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor NTRK3 BAX NELFB DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA EGF AREG G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNGT1 PLCB3 PLCB1 PLCB2 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system H2AC6 H2AC7 H2AX C1QBP F12 KLKB1 H3-3B H2AC19 H2AC14 H3C8 KNG1 H2BC12L H2BC26 H2BC21 H3C15 PRCP H2BC17 H2BC12 A2M H2BC13 H2BC14 H2BC15 HRG KRT1 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 H2AZ1 PLAUR H2AB1 H2AC20 SERPING1 H2AC8 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SUMO2 UBA2 SAE1 SUMO1 SUMO3 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) IRAK4 BTK TLR1 S100A1 TLR6 CD36 TLR2 TIRAP S100A9 S100A8 FGB FGA MYD88 FGG TLR4 LY96 CD14 HMGB1 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAPK3 MAP2K1 MAP2K2 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 SFTA3 CSF2RB SFTPC SFTPD CSF2RA SFTPB SFTPA1 SFTPA2 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection CD3G RAC1 VAV1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 IGHG3 IGHG4 IGHG1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 WASF3 MYO10 MYO1C CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling DPYSL2 PLXNA2 PLXNA3 FES CRMP1 SEMA3A CDK5 PLXNA1 NRP1 FYN GSK3B DPYSL4 DPYSL5 CDK5R1 DPYSL3 PLXNA4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins GGCX FURIN GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD CSPG5 CSPG4 NCAN BGN DCN CHST3 BCAN VCAN SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants PTPN6 TFG GZMB TPR FN1 RANBP2 JUN UBA52 IL10RA CCNB1 TYK2 DNMT1 CUL1 MDM2 RRBP1 MCL1 JUNB TWIST1 RNF213 UBB MSN IL22 UBC RPS27A CEBPB SEC31A CARS1 MAPK9 RBX1 MAPK8 RB1 CDKN1A HDAC1 KLC1 DCTN1 SQSTM1 STAT1 TPM4 TPM3 FRS3 MAPK1 STAT3 MAPK3 PLCG1 FRS2 PRF1 FOXM1 EEF1G ICOS ZC3HC1 TP53 RPS6 NPM1 IRF4 PPFIBP1 KIF5B LMO7 ALK IRS1 EML4 PPM1B HIP1 PRKAR1A PIK3CB BCL11A EIF2AK3 IL10 BCL2A1 STRN BIRC6 MYH9 STAT5A GRB2 ATIC PIK3R2 CLTC PIK3CA PIK3R1 WDCP GCC2 ZAP70 VCL MOV10 AGO3 AGO4 AGO1 AGO2 SKP1 TNRC6C RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib HSP90AA1 CDC37 ERBIN ERBB2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 FOS ATF1 UBB ECSIT NKIRAS1 NKIRAS2 UBC IKBIP MEF2A RPS27A DUSP4 DUSP3 NFKB1 IRAK4 VRK3 MAPK9 NFKBIA DUSP6 MAPK8 DUSP7 MAPK7 TLR10 TLR5 LRRC14 ELK1 USP14 NLRX1 PELI3 PELI2 NFKBIB NLRC5 MAPK10 NOD1 NOD2 AGER USP18 IRAK2 MAPK1 S100A12 N4BP1 MAP3K1 MAPK3 S100B TNIP2 MAP2K1 SAA1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 TP53 ATF2 NFKB2 HMGB1 RPS6KA5 CASP8 UBE2N TIFA TAB3 ALPK1 TAB2 TAB1 IRAK1 PPP2R5D MEF2C TRAF2 RPS6KA3 PELI1 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 ITCH PSMA3 PRKACA PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PSMD11 PRKACB PSMD14 GLI1 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SUFU NUMB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi MGAT2 CHST8 CGA LHB ST6GAL1 MGAT4C B4GALT2 MGAT4A B4GALT3 MGAT4B B4GALT1 CHST10 ST8SIA6 ST8SIA2 ST8SIA3 B4GALT6 B4GALT4 B4GALT5 MAN2A2 FUCA1 FUT3 FUT8 MAN2A1 MGAT5 MGAT3 ST3GAL4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 CPSF1 NUP85 CPSF4 CPSF3 EIF4E CPSF2 WDR33 NUP37 FIP1L1 SYMPK SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT DKK1 DKK2 DKK4 H2AX PYGO1 PYGO2 SFRP1 SFRP2 ASH2L AMER1 CSNK1G2 BCL9L BCL9 CCDC88C CHD8 USP34 RAC1 CBY1 RSPO2 SOST RSPO1 RSPO4 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 CXXC4 LRP6 ZNRF3 WIF1 H2AJ SRY RYK LGR6 LGR5 LGR4 PIP5K1B CTNNB1 H3C15 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 SMARCA4 H2BC1 H2AB1 TLE1 TLE5 H2AC8 H2AC6 H2AC7 TCF7 CSNK1E CSNK1A1 TERT GSK3B RHOA DPY30 PARD6A XPO1 H2BC26 CTBP2 H2BC21 CTBP1 WDR5 EP300 H2BC17 DAAM1 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP RAC3 H2BC11 LEF1 RBBP5 PPP3CA TCF7L2 PPP3CB H2AZ2 TCF7L1 PPP3R1 TNRC6C AXIN2 NFATC1 TNRC6A CALM1 AP2A1 TNRC6B AP2A2 AP2M1 SOX9 RBX1 YWHAZ AP2S1 WNT2B RAC2 HDAC1 GNGT1 AP2B1 GNGT2 KLHL12 HECW1 WNT5A CAV1 WNT9B WNT9A WNT16 RSPO3 WNT8A WNT8B PFN1 WNT6 GNG10 GNG3 GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 WNT2 SOX17 WNT3 WNT4 FZD1 WNT10B SNX3 FZD3 WNT10A FZD2 DVL1 FZD5 DVL2 FZD4 DVL3 WNT3A FZD7 WNT7B FZD6 TLE3 FZD8 WNT7A GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 VANGL2 GNB5 TNKS TNKS2 RNF146 CUL3 MEN1 APC CLTB PRKCG PPP2R1B PPP2R1A ZRANB1 WLS VPS29 VPS35 TMED5 VPS26A PPP2R5E SCRIB PPP2R5B CLTC PPP2R5A PPP2R5D CLTA PPP2R5C RUVBL1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 BTRC MAP3K7 SKP1 PPP2CA PRKCB PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PRICKLE1 PSMD11 PSMD14 CDC73 RUNX3 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 LEO1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 KMT2B PSMC1 PSMC2 TLE4 TLE2 SMURF2 SMURF1 GNAT2 KAT5 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 PLCB2 AXIN1 NLK PDE6B CAMK2A PDE6A PDE6G H2AC19 ITPR1 GNAO1 H2AC14 H2BC12L ITPR2 AKT2 SOX2 MYC ITPR3 AKT1 CSNK2A1 CSNK2A2 USP8 CSNK2B WNT5B ROR1 ROR2 PORCN ARRB2 H4C9 TRRAP SOX3 FRAT1 FRAT2 MOV10 SOX6 AGO3 SOX7 AGO4 SOX4 H2AC20 AGO1 RNF43 AGO2 CTNNBIP1 SOX13