CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2