HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 TAP1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP LDHB NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX FAS ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE HCTP4 CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK HDAC6 AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION NT5E ABI3BP GPC1 SPP1 SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 SDC1 PLOD2 PLOD1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 DKFZp686P11128 GJA1 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 NTM HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 ID2 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 ITGB5 MCM7 ITGB3 TNFAIP3 FAS LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 NOTCH2 THBS1 FSTL1 PTHLH FSTL3 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A CDC2 ATF1 HEL-S-71 GSK3B HRAS ARF1 CDKN1B CLTC UBE2D3 PRKAG1 PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR RPS6KA3 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 NCK1 ACTR3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 FGF7B IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 DDIT3 PIK3R3 DAPP1 NOD1 FGF6B IL2RG TRIB3 HEL-S-99n EGFR ACACA HEL-S-15 GNA14 MAPK9 MAPK8 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 HEL-S-47e PAK4 SMAD2 STAT2 PTPN11 MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 SFN CDK2 PIN1 GRB2 MYD88 NFKBIB TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS NT5E PSMC4 CTH GPC1 AGRN POLR3K PFKP VEGFA CDC2 CXCR4 DDIT4 EGFR AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 MIF SDC1 PLOD2 PHKA2 PLOD1 SAP30 TPST1 ENO2 CLDN3 CLDN9 RRAGD PKP2 KDELR3 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 RAA1 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN QSCN6 P4HA2 HEL20 GALK2 LHX9 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 TGFBI PGM2 ME2 SLC37A4 GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANGPTL4 ALDOB CHST4 LCT DLD MET B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE DCN GLRX NOL3 CENPA CLN6 MXI1 VCAN GPC3 GPC4 EGLN3 SLC35A3 B3GAT3 MDH2 CD44 BIK AGL TPBG B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING HDAC5 HDAC2 MAML1 HDAC11 LEF1 PSEN2 RBPJ NR1C2 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 NOTCH1 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 AXIN2 CSNK1E DKK4 DKK1 NCOR2 ADAM17 KAT2A NUMB CTNNB1 JAG2 CCND2 FZD8 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 TSSK2 CFTR DPEP3 DDX4 ALOX15 ART3 OAZ3 FLJ13057 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 IDE COIL TTK SHE HSPA4L HEL162 AURKA GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 NPY5R DCC PARP2 ELOVL3 SIRT1 CAMK4 MLF1 TSN ARL4A DBF4 MEP1B DMC1 HEL-S-278 ACRV1 TULP2 CST8 AKAP4 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS CTH RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A CTNNB1 APP SPTAN1 CCND2 FDXR F2R SQSTM1 TAP1 DDIT3 TXNIP ATF3 ROCK1 RETSAT NEDD9 NEFH TNFSF6 HMOX1 CDK2 JUN GADD45A BMP2 IFITM3 PRF1 PLAT ENO2 CLU TNF CCND1 TNFSF10 BTG2 BNIP3L CDKN1A HGF CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BCL10 EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 BRCA1 IL1A CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 GADD45B AVPR1A F2 DNAJC3 HEL-75 IRF1 IL1B IL6 DPYD RARA ETF1 PLCB2 BIRC3 RNASEL GUCY2D SATB1 CASP6 SLC20A1 PLPPR4 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 BAX MGMT FAS CD2 WEE1 KRT18 CD69 TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 CD44 BIK HEL-S-44 HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 CD59 ITGAM CPQ DOCK9 PLEK PCSK9 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL KYNU CTSH KLNA1 OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 DOCK4 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-S-130P HEL-76 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 L3MBTL4 C1QA USP14 CEBPB SCG3 USP15 USP16 C1S C1R SERPINC1 TMPRSS6 LCK SRC WAS GNAI3 PLG PFN1 PRCP RAF1 RNF4 PPM2C GNG2 SPOCK2 CCL5 FYN SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 RAA1 CASP9 CASP3 CASP4 F2 TFPI2 IRF1 IL6 ME1 TNFAIP3 CXCL1 CDK5R1 DGKG FCN1 CDA GMFB C4BPB LIPA NR2A1 DOCK10 TIMP1 LAMP2 PIM1 ACTN2 HPCAL4 GPD2 FDX1 ADAM9 SERPING1 LAP3 PLAUR S100A9 CFH GATA3 PLA2G7 PIK3R5 C2 DPP4 VCPIP1 PPP4C MMP14 C9 S100A13 S100A12 RCE1 STX4A LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 PLK1 MYC CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC AURKA DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 CHEK1 NBN CDK4 LIG1 HUS1 ILF3 DDX39A MSH2 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP CENPE NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 CDKN3 PLK4 HEL25 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 CDKN1A STAG1 CDC25B KIF18B UBE2S UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 HMGB3 PSIP1 CTCF CKS1B CROP ING3 HMMR MYBL2 TK1 LBR POLE TCF19 HELLS RFC3 RFC2 EED TUBB CTPS1 TUBG1 HMGB2 CIT BRCA1 MMS22L CKS2 MCM3 RAD51C MCM5 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB PCNA UNG NASP POLD3 PSMC3IP TRA2B EXOSC8 POLD2 PPP1R8 USP1 PMS2 PPM1D RBBP7 E2F8 GINS1 H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 GINS4 DONSON CDKN2A RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A MCM7 RPA3 BRMS1L RQCD1 TACC3 WEE1 CENPM RAD1 TRIP13 RAN SPC24 SMC3 MAD2L1 SMC4 DEPDC1 SPC25 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT HCTP4 TNPO2 CCNB2 SS18 RBM14 HEL-S-72p HEL164 H2BC12 CCNA2 SLC7A5 SFPQ RBL1 TFDP1 DTYMK DKFZp666G145 SLC7A1 PLK1 HIRA PURA MYC WRN CDC45 NSD2 E2F2 CDC2 DMD E2F3 E2F4 SRSF10 GINS2 CASP8AP2 H2AZ2 CDKN1B POLS EGF TOP2A MAPK14 PML NUMA1 CUL4A KIF11 MEIS1 pk BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 PAFAH1B1 EZH2 JPT1 TTK AURKA MKI67 CDC20 KATNA1 PTTG1 CHEK1 CDK4 HUS1 ILF3 DDX39A DBF4 TGFB1 CENPE MARCKS CENPF SLC12A2 PRC1 NOLC1 PDS5B ORC6 RAD21 BARD1 CDKN3 PLK4 SAP30 HMGA1 CCND1 POLA2 STAG1 CDC25B UBE2S HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B HMMR MYBL2 LBR POLE CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB NASP TRA2B H2AZ1 CDKN2C TACC3 MAD2L1 SMC4 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 CDC27 NUSAP1 HMGN2 TLE3 NEK2 SLC38A1 SMARCC1 FBXO5 PRP4K KNL1 TRAIP DKC1 HEL-S-61 EWSR1 NCL KNTC2 NUP98 ATF5 CUL5 CENPA YTHDC1 TROAP EFNA5 HIF1A STIL UBE2C CBX1 FANCC CDC6 FOXN3 KIF20B SQLE UCK2 MNAT1 SETD8 NOTCH2 AMD1 HOXC10 CHAF1A CHMP1A HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 ECI2 AQP7 CPOX UBE2L6 HEL-76 ENO3 IL4I1 TDO2 HEL-S-53e UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 RETSAT ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL HSDL2 NBN HMGCS1 ELOVL5 CYP4A11 FACL4 HEL-S-25 S100A10 INMT HADHB UGDH HEL-S-278 ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD ETFDH HSD17B4 EPHX1 LTC4S HSD17B11 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH SDHC PCBD1 ACSS1 MIF AADAT G0S2 GAD2 FABP1 ENO2 GSTZ1 FABP2 SUCLA2 APEX1 CRAT METAP1 HEL-S-133P HEL-S-32 H2AZ1 ME1 HEL-S-26 DLD GPD2 ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB MAFF PLEK VEGFA MYC KYNU PTX3 OLR1 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 TNLG5A SQSTM1 TAP1 CCL5 NINJ1 ATF3 JUN GADD45A MARCKS PLK2 LIF PTPRE BMP2 TNC G0S2 MXD1 TNF CCND1 BTG2 CDKN1A CD83 BTG1 CSF2 CSF1 CD80 ETS2 IFIT2 ZFP36 ZC3H12A CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A PHLDA2 CCNL1 PHLDA1 JUNB MCL1 ICOSLG GEM IER2 IL15RA SPHK1 IL23A SIK1 PLPP3 TRIB1 IL6ST FOS BHLHB2 FUT4 BTG3 SOCS3 SNN IL1A MSC ABCA1 EGR1 SDC4 EGR2 TIPARP TNFRSF9 HBEGF NFKB1 PPP1R15A NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 RCAN1 YRDC IL18 CXCL11 NR4A3 GADD45B BCL6 GPR183 B4GALT1 REL NFKBIE INHBA IL7R IRF1 NFE2L2 IL1B DRAM1 IL6 RIGI TNFAIP6 TNFAIP2 SLC2A3 CXCL3 BIRC3 LITAF ID2 SLC2A6 CXCL2 PANX1 IFIH1 PDE4B RELA KLF10 TGIF1 DUSP4 CXCL6 KDM6B KLF4 EDN1 DUSP2 RIPK2 IFNGR2 TRAF1 TNFAIP3 SERPINB8 TUBB2A CXCL1 SGK1 FJX1 AREG BIRC2 CD69 CYR61 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD PTGS2 TANK SUI1 RELB NFIL3 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 PLAUR CCL20 ATP2B1 KLF2 PNRC1 RHOB PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 TRIP10 TMEPAI ACKR3 F2RL1 FOSB CD44 EHD1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING SLIT1 NRCAM NKX6-1 L1CAM CDK6 MYH9 VEGFA ETS2 HEY2 NF1 CDK5R1 PTCH1 PML OPHN1 TLE3 SCG2 THY1 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 PLG CELSR1 AMOT VLDLR SHH HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC CLU TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 HEL-S-4 GNAI1 STARD4 PCYT2 GPX8 SREBF2 ETHE1 PPARG EBP STX5A MVD ACSS2 HEL-S-7 MVK SEMA3B LPL HMGCR ATXN2 PMVK TP53INP1 MAL2 FDFT1 CTNNB1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 PLSCR1 SCD CD9 DHCR7 CPEB2 AVPR1A IDI1 ACAT2 GUSB TRIB3 ATF3 SC5D FASN NFIL3 TNFRSF12A HMGCS1 LDLR PLAUR PNRC1 ATF5 PDK3 HSD17B7 SQLE HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 CD82 KIF1B NPFFR2 IRF7 CSF3 LCP2 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IL18RAP RGS1 LAMP3 CLEC5A C3AR1 PROK2 LCK ROS1 TNLG5A SCN1B GNAI3 CMKLR1 IL1R1 SLC11A2 RAF1 CYBB IFNAR1 LY6E CALCRL CCL5 EBI3 C5AR1 FPR1 CD55 LPAR1 SLC1A2 MEFV HRH1 IRAK2 NLRP3 NDP ARHG MSR1 FZD5 EIF2AK2 NMI SELE BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B HEL-S-75 MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 LIF SRI ATP2C1 SLC7A2 CCL7 PTPRE P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 MXD1 SEMA4D SLC31A2 SLC31A1 PCDH7 IL10RA ADRM1 TNFSF10 BTG2 OSM CDKN1A OPRK1 ACVR2A P2RX7 CSF1 EREG P2RX4 AXL IL2RB TNLG8A VIP PSEN1 IL18R1 CCRL2 NAMPT IL12B CD14 ICOSLG IL15RA SPHK1 IL1A ABCA1 TNFRSF9 HBEGF NFKB1 NFKBIA RGS16 IL18 CXCL11 ACVR1B GPR183 INHBA IL7R IRF1 IL1B IL6 TNFAIP6 PDE4B RELA GNA15 CXCL6 CXCL8 EDN1 RIPK2 IFNGR2 ITGB3 CD69 ADORA2B PTGER4 TIMP1 MET IL15 CCL2 LDLR PLAUR CCL20 ATP2B1 EMP3 PIK3R5 KLF6 GPC3 HIF1A MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING ID2 SLC20A1 KLF10 TGIF1 SPTBN1 IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 JUNB ACVR1 NCOR2 UBE2D3 SMAD1 WWTR1 SMURF2 SMURF1 CTNNB1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 FKBP1A SKI RAB31 ARHA MAP3K7 ID1 ID3 BMPR1A ENG PPP1R15A TGFB1 TMEPAI APC THBS1 BMP2 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE HLA-DMA SLC25A28 PSMB2 STAT4 FCGR1A PFKP GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PSMB8 ZNFX1 PTPN6 PML UBE2L6 PLSCR1 IRF2 IFI30 IRF7 LCP2 C1S C1R CMKLR1 TRAFD1 TAP1 LY6E CCL5 FPR1 NOD1 TXNIP GZMA RAPGEF6 EIF2AK2 NMI BST2 RIPK1 RTP4 CD40 CXCL9 STAT2 SOCS1 ARL4A MYD88 MTHFD2 TAPBP SRI CCL7 IFITM3 IL10RA TNFSF10 RBCK1 CDKN1A BTG1 IL2RB IFIT2 NAMPT IL15RA SOCS3 VAMP8 CASP8 CASP3 CASP4 ISG20 SAMD9L NFKB1 IFITM2 SPPL2A IFI35 NFKBIA IFIT1 IFI44L IFIT3 PNP VCAM1 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 ZBP1 IFNAR2 IL6 RIGI RSAD2 TNFAIP6 SP110 TNFAIP2 HLA-B ARID5B HLA-A HLA-G NUP93 IFI27 PSME2 IFIH1 CMPK2 PDE4B TRIM14 IDO1 CSF2RB HELZ2 KLRK1 RNF213 ST8SIA4 RIPK2 ISOC1 SLAMF7 ST3GAL5 TNFAIP3 FAS HLA-DQA1 PNPT1 AUTS2 IFI44 CD69 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 PTGS2 MT2A SELP IL7 SSPN PIM1 XAF1 GPR18 HLA-DRB1 LGALS3BP IL15 CCL2 OGFR EIF4E3 SERPING1 SECTM1 LAP3 ADAR OASL CFH IL18BP ITGB7 BATF2 ApoL6 TMT1B LATS2 BANK1 HIF1A OAS2 PSMA2 IRF4 OAS3 PELI1 XCL1 IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN CAP2 SLC7A1 MYC COL3A1 IRS1 PRDM2 NR3C1 PMP22 IGF1R PPARG ZMIZ1 AKT3 CDON IGFBP5 SFMBT1 PRKCE DYRK1A CDKN1B POLS PRKCA RUNX1 MAPK14 INPP4B MAP1B PTEN SCN8A AMPH MT1E F3 PTGFR INSIG1 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 ARHGEF9 RASA2 PLCB4 MMP16 FYN KCNMA1 KIT LPAR1 PIK3R3 GCNT1 MRPS31 TFPI ADD3 SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 MGLL CDC42BPA SRI ATP2C1 HAS2 ACVR2A RGS4 GJA1 SDC2 PLPP3 BHLHB2 TJP1 ID1 BMPR1A NFKB1 FBLN5 BDNF CITED2 COL1A1 VLDLR RXRA COL1A2 COL5A2 SNAI2 ERBB2 ITGB3 MGMT LAMC1 CYR61 ADORA2B MET LDLR ATP2B1 YTHDC1 TGFBR3 NRP1 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING PTPN1 TNF STAT1 STAT3 CSF2 CSF1 IL18R1 MAP3K8 CD36 CD14 IL15RA IL6ST SOCS3 CD9 CSF3R IFNGR1 STAM2 CXCL11 TNFRSF1A ACVR1B IRF1 IL1R1 IL1B IL6 IFNAR1 CXCL3 EBI3 BAK1 IL2RG CSF2RB IFNGR2 ITGB3 ACVRL1 FAS CXCL13 CXCL1 LEPR HAX1 ITGA4 IL1R2 DNTT TYK2 CXCL9 IL17RB IL17RA IL3RA STAT2 LTB PTPN11 TNFRSF21 IL9R IL7 CBL PIM1 CSF2RA SOCS1 PDGFC TNFRSF12A IL12RB1 A2M HMOX1 CCR1 IL10RB PLA2G2A INHBE GRB2 TNFRSF1B IL2RA MYD88 OSMR LTBR CRLF2 PF4 PIK3R5 JUN TGFB1 CD44 CNTFR IRF9 IL13RA1 CCL7 HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 AK1 XPC RFC4 LIG1 ARL6IP1 MPG GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM HPRT1 GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 ADA POLR3GL ALYREF UPF3B ADRM1 SUPT5H ZWINT POLA2 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 SNAPC5 SEC61A1 MRPL40 ZNRD1 GUK1 SNAPC4 REV3L AK3 DKFZp781O1323 DGCR8 ELOA NELFB POLL NELFCD NCBP2 NME3 VPS37D RFC3 NME4 RFC2 EDF1 VPS37B APRT NT5C3A DDB2 DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA CANT1 GTF3C5 RNMT PRIM1 PCNA USP11 GPX4 DCTN4 POLD3 GMPR2 TAF9 PNP TYMS ADCY6 POLD4 POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J RAE1 DUT POLR2K BRF2 TAF12 PDE6G TAF13 TAF10 GTF2H3 CMPK2 PDE4B GTF2H5 TARBP2 SSRP1 RAD52 RAD51 POLE4 POLR3C NUDT21 IMPDH2 ERCC1 ERCC2 BCAP31 RPA3 TAF6 DFNA5 ERCC5 CDA HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS EPHX2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HSPB8 ETFB PPARG GPHN AIFM1 ALDH2 CD36 NKIRAS1 DBT LPL DLAT YWHAG ADIG COX8A JAGN1 CHUK ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 SUCLG1 CAVIN1 NDUFA5 CAVIN2 RIOK3 SQOR VEGFB CYP4B1 ADIPOR2 IMMT DHRS7 PFKL FABP4 GPAM DECR1 CCNG2 LEP HEL-S-62p LPCAT3 NDUFAB1 CIDEA ATP5PO ESYT1 PEX14 ACO2 REEP6 RETSAT ACADL CPT2 ACADM ACADS ARL4A ACOX1 MGLL ECHS1 GADD45A LTC4S AK2 SDHC CRAT MYLK COL4A1 ABCA1 GPX4 GPX3 IFNGR1 ADCY6 BCL6 TOB1 CDKN2C STOM ME1 SCARB1 HEL-S-26 MTCH2 SLC27A1 ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 SLC25A10 MCCC1 ANGPTL4 TANK OMD ATP1B3 SSPN CMBL SDHB DLD SLC5A6 ACLY GPD2 POR ADFP RAB34 CMPK1 HEL-S-87p UQCRC1 SPARCL1 PREB RTN3 CD151 MTARC2 MGST3 ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 GRPEL1 MDH2 DHRS7B UBC G3BP2 APOE CYC1 RREB1 HEL-S-44 SLC19A1 ESRRA FZD4 HEL107 HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION HLA-DMA STAT4 CD74 STAT1 CTSS PTPN6 HEL-S-71 MAP3K7 IRF7 LCP2 CCND3 NCK1 CCND2 PRKCB IL18RAP TRAF2 LCK WAS F2R CD1D TAP1 CCL5 GCNT1 IL2RG GZMA NLRP3 SPI1 EGFR GPR65 NCF4 CD40LG UBE2D1 RPL9 IL27RA RPS19 CXCL13 SIT1 IL12A HLA-DOA HLA-DOB RPL39 TPD52 CD40 CD96 CXCL9 RPS9 KRT1 TAP2 LTB CARTPT HLA-E IL4 STAB1 CD8A FLNA AARS1 SOCS1 IGSF6 TNFSF6 CFP IL12RB1 CD79A IL10 ELANE CCR1 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L TAPBP PTPRC TLR1 PF4 IL9 HLA-DRA TGFB1 DEGS1 KLRD1 ITK TLR3 DYRK3 CD3G CD3E CD3D IKBKB LIF MRPL3 INHBB CCR5 CCR2 MBL2 CCL7 RARS1 EIF5A MAP4K1 SRGN IL11 IL13 CD8B1 IL16 RPS3A CCL22 MMP9 PRF1 NCR1 ZAP70 IFNG TNF ELF4 CD47 BCAT1 CCL13 CCL11 ACVR2A MTIF2 CSF1 EREG HDAC9 CD80 HLA-DMB CXCR3 IL2RB CSK CCL19 GBP2 BCL10 NPM1 NOS2 TRAT1 IL12B GALNT1 c-fgr CD7 EIF3J ABCE1 HEL-S-66 FCGR2B EIF3D ICOSLG EIF3A BRCA1 HCLS1 THY1 IFNGR1 IL18 F2 B2M INHBA IL1B IFNAR2 IL6 HLA-A HLA-G CDKN2A ST8SIA4 RIPK2 IFNGR2 FAS HLA-DQA1 CD2 IL7 TIMP1 CCL4 IL15 CCL2 C2 HIF1A IRF4 ACHE LYN IRF8 PSMB10 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE SLC25A28 IFITM3 GBP4 CD74 CD47 MX1 CSF1 PSMB8 IFIT2 GBP2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 NCOA7 UBE2L6 CNP SAMD9 UBA7 PLSCR1 GMPR CASP8 MVB12A MOV10 IRF2 IFI30 IRF7 ISG20 IFITM1 SAMD9L IFITM2 IFI35 IFI44L IFIT3 C1S LAMP3 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 RSAD2 TRAFD1 SP110 TAP1 LY6E PROCR IFI27 IFIH1 PSME2 CMPK2 TXNIP TRIM14 HELZ2 RIPK2 EIF2AK2 NMI BST2 PNPT1 SELL IFI44 RTP4 ISG15 TDRD7 PARP14 STAT2 PARP12 IL7 LGALS3BP IL15 OGFR ADAR LAP3 OASL BATF2 IRF9 RNF31 USP18 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY MPPED2 TFF1 FOXC1 SLC24A3 ATL1 TMPRSS3 ASB13 SLC7A5 ADCY1 PAPSS2 THSD4 TMEM164 ABLIM1 MUC1 PDLIM3 OLFML3 LRIG1 MYC RBBP8 SH3BP5 EEIG1 HSPB8 MICB IGF1R CA12 SVIL KDM4B NHERF1 ZNF185 SEMA3B AMFR KRT13 SNX24 NCOR2 DHRS2 KLK10 DHRS3 TTC39A FDFT1 KRT19 MLPH MYBBP1A CHPT1 RAB17 GLA FRK TJP3 ABAT DHCR7 FHL2 SLC22A5 ADD3 FASN IL17RB FLNB ELOVL5 SFN SLC19A2 FARP1 INHBB SLC7A2 P2RY2 CCND1 FKBP4 GJA1 IGFBP4 PMAIP1 STC2 ELF1 IL6ST FOS BHLHB2 RAB31 FCMR WWC1 TIPARP HR CANT1 NADSYN1 AQP3 CELSR2 RAPGEFL1 SOX3 DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU B4GALT1 MREG CISH TOB1 NPY1R KAZN KCNK15 OVOL2 RARA SULT2B1 OLFM1 CXCL12 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 SLC27A2 PTGES KLF10 FKBP5 SLC26A2 HEL-S-10 KLF4 MINDY1 TPD52L1 ARL3 ABHD2 SLC1A1 ENDOD1 SCARB1 ISG20L2 RHOBTB3 SLC1A4 UGCG MED24 KRT18 SYNGR1 AREG ELF3 CALCR INPP5F ALDH3B1 TFF3 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 ABCA3 GREB1 MED13L REEP1 HES1 KCNK5b BCL2 UNC119 RETREG1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 TIAM1 DYNLT3 CD44 ELOVL2 ITPK1 TPBG MYOF PLAAT3 GAB2 NAV2 CELSR1 CBFA2T3 RHOD ESRP2 HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAFF GPC1 PFKP ERRFI1 RBPJ SLC25A1 VEGFA NR3C1 CA12 CDKN1B PRKCA MT1E F3 ENO3 TES RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN PPP1R3C PKP1 LXN HACL2 FOXO3A PRDX5 LARGE LYZG PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX CAVIN1 NCAN HEXA HEL-S-134P ANXA2 PYGM BRS3 AKAP12 CSRP2 STBD1 ATP7A PFKL EDN2 GAA MYH9 CXCR4 DDIT3 AMPD3 CCNG2 DDIT4 FBP1 CHST3 TMEM45A S100A4 KDM3A DGIC EGFR HAS1 NOCT GCNT2 ATF3 VHL XPNPEP1 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 NAGK INHA TPD52 ADM HMOX1 ERO1A HEL-S-278 JUN HEL-S-75 ZNF292 ENO1 HEL-S-89n DPYSL4 PDK3 MIF SAP30 ENO2 RRAGD CTGF KDELR3 BNIP3L CDKN1A BTG1 ZFP36 CDKN1C SDC2 SDC3 STC1 AK4 LOX STC2 ANKZF1 FOS BHLHB2 HEL-S-133P SDC4 B3GALT6 TIPARP EXT1 ISG20 PPP1R15A EFNA3 FOSL2 P4HA1 EFNA1 P4HA2 CCN5 CITED2 IL6 VLDLR HK2 SULT2B1 SLC2A3 GYS1 CASP6 TGFBI PGM2 SLC37A4 PGAM2 HEL-S-68p SCARB1 TNFAIP3 HEL-S-19 CYR61 ADORA2B MT2A ANGPTL4 ALDOB PIM1 SIAH2 NFIL3 ADFP BCL2 PLAUR HEL-S-87p DCN GLRX PNRC1 KLF6 MXI1 GPC3 GPC4 ACKR3 TPBG CP HEL-S-49 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE SLC7A5 NABP1 VEGFA HEL-S-125m IGFBP1 CEBPB DNAJB9 TSPYL2 DDIT4 HEL-S-99n ATF3 EIF4E EIF4A2 EIF4A1 POP4 EIF4A3 RRP9 EDC4 RPS14 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ERN1 NHP2 ATP6V0D1 ERO1A MTHFD2 TARS1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS HEL-S-89n EDEM1 LSM1 ASNS EEF2 LSM4 CNOT4 NOLC1 CNOT6 CNOT2 SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 SERP1 WIPI1 YWHAZ SKIC3 EIF2S1 DCP2 EXOC2 KDELR3 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 H2AX SEC11A EXOSC1 NPM1 PAIP1 NFYA NFYB SPCS3 CKS1B SPCS1 XPOT DNAJA4 PSAT1 STC2 IFIT1 DNAJC3 NOP56 TUBB2A SLC1A4 XBP1 WFS1 CCL2 DKC1 HEL-S-61 PREB HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE ADIPOR2 GSTM3 PCSK9 IL2RG IL2RB AKAP7 LYPD3 CX3CL1 SLC2A4 PKHD1 SCUBE1 FLOT2 APP ATP6V0A4 EPHB4 TMEM8B NTNG1 SLC34A3 ATP8B1 BRCA1 CD160 PLAUR NCOA6 ADAM10 GATA3 SULF2 RTN4RL1 CROCC MAL HEL-S-102 GHRL THY1 EFNA5 RHCG MDGA1 GAS1 SHROOM2 LYN B4GALT1 SRPX HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 CLCN3 ADD2 AGPAT4 NR3C1 RHD E2F2 TRAK2 FY MARCHF8 CIRSR DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 CPOX SLC25A38 HEL-76 SLC25A37 TSPO2 XK HEL-S-2a RHAG UROD YPEL5 LPIN2 TNRC6B MAP2K3 CCND3 ICAM4 ARHGEF12 UCP2 FOXO3A USP15 HEL-S-134P RIOK3 SLC11A2 HEL-S-62p UROS TFRC HBZ BCAM ASNS HEL-S-304 SDCBP BTG2 BNIP3L SLC7A11 ABCB6 H1-0 AQP3 GCLC ISCA1 NARF GDE1 SLC4A1 P4HA2 BACH1 CCDC28A PPP2R5B NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 SLC30A1 SLC6A8 GAPVD1 MYL4 MINPP1 RNF123 KEL hEMMPRIN DAAM1 ADD1 HMBS GLND1 RHCE HEL-S-10 OPTN ABCG2 OSBP2 SIDT2 SLC22A4 ENDOD1 EPB42 FECH GYPC IGSF3 GYPB GYPE DCUN1D1 HTRA2 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP LAMP2 CDC27 SPTA1 TSPAN5 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 SYNJ1 MGST3 MKRN1 MXI1 RANBP10 TMCC2 LRP10 GCLM EZH1 NFE2L1 TMEM9B PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 PC HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION GOSR2 RNP24 ANP32E COPB2 CLCN3 CTSC ARF1 CLTC IGF2R PPT1 RPS6KA3 GLA ADAM10 ABCA1 KIF1B AP2M1 SNAP23 CLTA RAB22A GOLGA4 SCRN1 AP1G1 DST AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 ERGIC3 SEC22B VAMP4 ATP6V1B1 ATP7A VAMP3 NAPA CD63 STX12 TMED10 SGMS1 STX16 COPB1 VPS4B USO1 EGFR ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 MAPK1 YKT6 ARFGEF2 KRT18 MON2 CAV2 TPD52 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A GNAS LAMP2 SSPN YIPF6 RAB9A RAB5A COPE BET1 ARFGEF1 ZW10 SEC31A TSG101 HEL-S-44 COG2 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION SLIT2 ACTG1 MYH10 GNAI1 IRS1 AKT3 NF1 MVD MAPK14 PTEN WASL pk INSIG1 ICAM4 SHROOM2 RHOF SRC PFN1 VAV2 MYH9 PIK3R3 EGFR NF2 PLCG1 CX3CL1 CTNND1 ICAM2 INPPL1 FYB1 LNIR HEL-S-79 DMP1 ICAM5 ACTG2 PTPRC CDH8 SHC1 TIAL1 CDH4 SIRPA NRTN HEL70 SCAP2 GTF2F1 JAM3 ACTN1 CLDN6 CLDN5 CLDN4 TAOK2 ADAM15 CERCAM ALOX15B COL16A1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK MMP9 RSU1 CD99 CLDN9 VASP CADM3 CDSN JUP CRAT CADM2 PARVA CDH6 CDK8 ITGB4 ARPC2 CD209 CNTN1 COL9A1 PALS1 ADRA1B PKD1 SGCE TRO SDC3 ADAMTS5 PS1TP5BP1 MDK DHX16 HRAS SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK VWF HEL-S-20 TMEM8B KRT31 CLDN11 TJP1 TUBG1 ACTA1 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL CDH15 NLGN3 TNFRSF11B NLGN2 THY1 AMIGO1 AMIGO2 NRXN2 PARD6G THBS3 LIMA1 VCAM1 ADAM23 NRAP CTNNA1 MPZL1 B4GALT1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 BMP1 PPP2R2C ZYX NECTIN3 NECTIN2 CLDN7 CRB3 NECTIN1 TGFBI FBN1 ITGB1 BAIAP2 TRAF1 LAMC2 HEL114 ACTN2 ITGA2 ADAM9 MMP2 LAMB3 TSC1 ACTN4 CALB2 VCAN CDH11 STX4A LAMA3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 NKX6-1 PCSK2 PCSK1 STXBP1 NR1i1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PKLR PDX1 GCG PAX6 GCK ELP4 AKT3 HNF1A SYT13 ISL1 SPCS1 SRP9 G6PC2 MAFB SST DCX IAPP INSM1 FOXA2 NEUROG3 DPP4 SRPRB HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM CYP2J2 GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 TMEM97 LR8 CYP2S1 PAPSS2 CYP1A2 HRG NMT1 GUGU ABCD2 NR1C2 PEMT ALAS1 LEAP2 CROT AOX1 ACP2 MAN1A1 KYNU HGFAC ABCC3 ARG2 ABCC2 ALDH2 CD36 HEL-S-21 ARG1 DHPS SSR3 PTGR1 NPC1 SMOX ANGPTL3 TMBIM6 ACOX3 CYFIP2 CRP ITIH4 DDC KARS1 HEL-S-51e CYP17A1 HEL-76 PGRMC1 SERTAD1 ATOH8 TDO2 HSD17B2 XDH MARCHF6 IGFBP1 CCL25 LPIN2 MPP2 NQO1 PTGES3 GABARAPL1 F11 AQP9 DDT AKR1C2 HEL-S-182mP DHRS1 PINK1 GSTA3 CDO1 ALDH3A1 TNFRSF1A PLG IL1R1 MAOA ADH7 DHRS7 F10 FBP1 NINJ1 VNN1 GCNT2 EPHA2 CYP1A1 ACO2 RETSAT SLC35D1 ATP2A2 HMOX1 ELOVL5 UGDH ACOX1 PMM1 ADH1C ETFDH EPHX1 HPRT1 GAD1 BPHL MBL2 PTS TPST1 FABP1 JUP BCAT1 ETS2 IGFBP4 ARPP19 DCXR GCLC HEL-75 ID2 CASP6 PTGES HEL-S-10 HEL-S-26 FAS CDA NR2A1 MT2A RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 POR CNDP2 PDK4 ALDH9A1 LONP1 HEL-S-64p TYR MCCC2 HES6 ENTPD5 SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SAR1B SLC22A1 GSTT2 ABHD6 IRF8 NDRG2 CYP2C18 APOE ADH5 HSD11B1 VTN pcap TTPA ASL PSMB10 PC HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS VAV2 SPP1 COL5A2 MSX1 S100A4 CXCL6 VEGFA COL3A1 POSTN OLR1 STC1 LPL PDGFA ITGAV TNFRSF21 TIMP1 APP JAG2 PF4 CCND2 VCAN LRPAP1 NRP1 THBD APOH PGLYRP1 KCNJ8 VTN PRG2 FSTL1 SLCO2A1 FGFR1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS AGRN IGF1 HDAC5 PSEN2 ABLIM1 COL3A1 HSPB8 DMD SVIL CD36 RB1 APP FDPS ITGA7 ENO3 SCD SPTAN1 NQO1 PPP1R3C ACSL1 SCHIP1 TSC2 LARGE COX6A2 PYGM SLN GJA5 MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 GAA MYH9 MEF2C TPM3 DAPK2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 NOTCH1 FLII AEBP1 FOXO4 COX7A1 AK1 CNN3 EIF4A2 SYNGR2 IGFBP7 APOD PRNP CAV3 DMPK OCEL1 GNAO1 PKIA RIT1 FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 ATP2A1 LDB3 MYL6B MYOM2 HSPB2-C11orf52 CSRP3 SGCA TGFB1 MB BDKRB2 ANKRD2 HEL-S-101 MYBPC3 MYOG TEAD4 PTGIS TNNC1 DENND2B TNNC2 HEL-S-29 SPARC SIRT2 MYH1 MYH2 PTP4A3 TNNT1 LPIN1 TNNT3 CASQ2 PLXNB2 MYH8 PICK1 HEL-S-273 MAPRE3 CASQ1 FGF2 CLU KIFC3 MYH4 tmp_locus_29 MYH7 CRAT MYLK CDKN1A CTF1 CKMT2 ITGB4 EFS CHRNG DKFZp686P11128 TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SH2B1 SPDEF MYBPH PDE4DIP MAPK12 MYO1C SPEG KLF5 FKBP1B TCAP CACNA1H PFKM WWTR1 SPHK1 STC2 COL4A2 ADAM12 BHLHB2 ACTA1 HBEGF GPX3 GADD45B SORBS3 COL1A1 TNNI1 ADCY9 SLC6A8 MYL4 ITGB1 ERBB3 TPD52L1 ITGB5 PGAM2 SGCD BAG1 SSPN ACTN2 SGCG REEP1 ACHE BIN1 AGL NAV2 PC HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING PSMC4 CTH TMEM97 SLC7A5 TM7SF2 NMT1 FADS2 PLK1 STARD4 NHERF1 IGFBP5 GSK3B CTSC HMGCR UBE2D3 SLA NIBAN1 ELOVL6 HEL-S-125m INSIG1 HEL-S-51e GLA TBK1 CYP51A1 TES SCD CD9 HEL-S-162eP DHCR7 IFI30 MAP2K3 ACTR3 ACTR2 FDXR IDI1 SQSTM1 ADIPOR2 IMMT PFKL RDH11 CXCR4 DDIT3 PIK3R3 DDIT4 DAPP1 ADD3 IFRD1 TRIB3 DHCR24 HEL-S-99n NUPR1 USO1 ACACA PSMG1 YKT6 TFRC AURKA M6PR ATP2A2 RRP9 RIT1 CFP HMGCS1 ELOVL5 DDX39A NFKBIB ERO1A MTHFD2 SSR1 ENO1 NUP205 HEL-S-89n SCAP2 EDEM1 ASNS HPRT1 PLOD2 SERP1 BTG2 BCAT1 CDKN1A SLC7A11 SEC11A NAMPT EBP STC1 AK4 PSAT1 PITPNB PSPH FADS1 ACSL3 SYTL2 MTHFD2L AF1Q FKBP2 BHLHB2 PSMD12 TUBG1 PSMD13 RPN1 CORO1A ATP6V1D HEL-S-94n HEL-S-133P HEL-S-66p SDF2L1 HSPA4 PNO1 MCM2 PPP1R15A EIF2S2 HEL-S-283 GCLC CCT6A P4HA1 UNG DHFR COPS5 EPRS1 PNP ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 HEL-75 CANX EEF1E1 RAB1A VLDLR NUFIP1 HK2 TOMM40 ETF1 HSPD1 SLC2A3 HEL-S-69p GGA2 ABCF2 RRM2 CYB5B NFYC PDAP1 UFM1 ME1 PSMC6 RPA1 POLR3G HMBS SLC37A4 SC5D CCNG1 HEL-S-68p HEL-S-26 SLC1A4 XBP1 NFIL3 ACLY LDLR HEL-S-87p GLRX TUBA4A EGLN3 SQLE FGL2 HEL-S-49 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 FOXC1 SLC24A3 SERPINA1 TMPRSS3 SLC7A5 PAPSS2 PDLIM3 RBBP8 PTPN6 EEIG1 HSPB8 MICB ETFB CA12 NHERF1 GINS2 SEMA3B AMFR KRT13 NCOR2 DHRS2 TOP2A KLK10 FDFT1 KRT19 CHPT1 GLA HEL-76 FRK TJP3 FABP5 CD9 DHCR7 PTGER3 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 HSPA4L IL17RB CDC20 FLNB ELOVL5 SFN FARP1 UGDH ST14 RNASEH2A HPRT1 TNNC1 HEL-S-29 PLK4 CCND1 KIF20A FKBP4 ZFP36 IGFBP4 MDK DCXR IL6ST FOS BTG3 RAB31 HR ISG20 CELSR2 RAPGEFL1 SOX3 RPS6KA2 MYB CCN5 SORD TFPI2 CISH TOB1 NPY1R MAPK13 OVOL2 SULT2B1 PERP OLFM1 CXCL12 SCNN1A ID2 PPIF PGR NBL1 SLC27A2 NAB2 PTGES CXCL14 FKBP5 TRIM29 SLC26A2 UNC13B HEL-S-10 KLF4 METTL3 TPD52L1 CACNA2D2 ARL3 DUSP2 PRLR ABHD2 PCP4 PKP3 SCARB1 LLGL2 IGSF1 LAMC2 SLC1A4 PLAC1 SGK1 HOMER2 XRCC3 AREG CALCR CYP4F11 TH ALDH3B1 GJB3 TFF3 BAG1 DLG5 TFAP2C GPER XBP1 NMU OPN3 PLXNB1 FGFR3 WFS1 SERPINA3 SIAH2 MOCS2 ABCA3 ST6GALNAC2 SNX10 SLC2A8 IMPA2 KCNK5b TPSAB1 BCL2 JAK1 CHST8 S100A9 EMP2 RET LSR DNAJC1 CLIC3 GAL NXT1 JDP1 PRSS23 SLC29A1 AFF1 ASCL1 AGR2 CYP26B1 TM4SF13 STIL ANXA9 ASS1 KLK11 BATF TIAM1 CDC6 DYNLT3 CD44 ITPK1 TPBG MYOF PLAAT3 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION COX6B1 OXA1L COX7A2L RHOT2 COXFA4 UQCRC2 UQCRB ABCB7 CS ATP5MC2 ATP5MC3 ATP5J COX7A2 UQCRQ ATP5H UQCRH ACAT1 ALAS1 MRPL11 TIMM50 COX7B CYB5R3 RHOT1 COX11 NDUFV2 ATP5MG ETFB ATP5MF ATP6V1C1 AIFM1 COX10 ATP5ME ATP6V1F ACADSB DLAT GLUD1 OGDH CYCS COX8A MRPS15 SLC25A3 COX4I1 MRPS11 MRPS12 ETFA TCIRG1 NDUFS3 MRPL34 COX7C MRPL35 OPA1 NDUFB7 TIMM17A UQCRFS1 TOMM70 ATP6V0B UQCR11 MRPS22 NDUFC2 UQCR10 CPT1A NDUFC1 BDH2 NDUFS8 NDUFS6 VDAC3 NDUFS4 SDHD NDUFS1 SDHA SLC25A12 SLC25A5 ATP6V0C FXN SLC25A11 SLC25A4 SUCLG1 SLC25A6 NDUFB8 NDUFA5 NDUFB6 NDUFB5 NDUFB4 TIMM9 PPM2C NDUFB3 NDUFB2 IMMT TIMM13 NDUFB1 MRPS30 TIMM10 DECR1 HEL-S-123m PDHA1 COX5A MFN2 SLC25A20 NDUFAB1 MST065 ATP5PO NDUFA9 TIMM8B NDUFA7 ISCU NQO2 NDUFA6 ATP5PB MTX2 ACO2 ZNF183 NDUFA3 RETSAT ACADVL NDUFA2 ATP5F1D HCCS ATP5F1E IDH3B LDHB ACADM HADHB FH LRPPRC ECHS1 ETFDH HSD17B10 COX17 SDHC SURF1 SUCLA2 GOT2 ATP6V1D HEL-S-133P ISCA1 GPX4 ATP5G1 HEL-S-32 POLR2F BAX HEL-S-26 COX6A1 HTRA2 PHYH SDHB DLD POR FDX1 PDK4 UQCRC1 MGST3 MRPL15 PRDX3 MTRR GRPEL1 MDH2 PHB2 HEL-S-271 MTRF1 MPC1 PMPCA CYC1 ATP6V1E1 PDHX ATP6V1G1 NNT ATP6V0E1 ATP1B1 HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE CDK6 PA2G4 CCND1 ADRM1 ZMIZ1 SPDEF ANKH SPCS3 HMGCR INPP4B H1-0 FADS1 KRT19 ACSL3 INSIG1 RPS6KA3 SCD CCND3 DNAJB9 PTPN21 SORD SMS B4GALT1 B2M HEL-75 GNAI3 IDI1 AKAP12 ARID5B FKBP5 SLC26A2 DHCR24 ABHD2 LMAN1 SGK1 HOMER2 SRP19 STEAP4 TPD52 NGLY1 DBI CDC14B HERC3 ITGAV PGM3 SMP1 NKX3-1 PIAS1 ALDH1A3 MAF HMGCS1 MAK ELOVL5 SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I XRCC5 HPGD APPBP2 TMEPAI VAPA ACTN1 CENPN GPD1L MERTK HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP SPP1 LR8 CTSS PRRX1 PSMB8 CROT ARG1 SEMA3B ADAM17 FCER1G HEL-76 RETN CCND2 SCG5 SCG3 NGF C3AR1 SCN1B CMKLR1 PCSK1N AKAP12 CXCR4 TFPI SNAP91 CIDEA IL2RG DOCK2 MAP3K1 APOD CBL CSF2RA ALDH1A3 TNFRSF1B ERO1A FUCA1 PLVAP SPON1 LIF HCA112 SOX9 F13A1 PRDM1 IKZF1 FGF9 BMP2 MAP4K1 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC G0S2 CLEC4A MMP9 SLPI PLAT MALL ADAM8 TRIB2 IL10RA ZNF277 TPH1 JUP ABCB1 LY96 CSF2 TSPAN7 EREG EPB41L3 HDAC9 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 IGF2 AMMECR1 PPBP NR0B2 ANKH GNG11 GADD45G CCSER2 STRN AVL9 PIGR SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 VWA5A TRIB1 TEM5 CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 PECAM1 LAT2 MMP11 ZNF639 HBEGF ENG ALDH1A2 PPP1R15A TLR8 LCP1 SDCCAG8 USP12 RGS16 USH1C HOXD11 YRDC IL1RL2 RELN EMP1 GPNMB CBR4 MPZL2 IL33 PTCD2 GALNT3 INHBA IL7R H2BC3 IL1B GABRA3 NR1H4 LAPTM5 NAP1L2 WNT7A BIRC3 TMEM158 CFHR2 ID2 SPRY2 SATB1 ADGRL4 KLF4 PCP4 TRAF1 TNFAIP3 GYPC MAFB PTGS2 ANGPTL4 SERPINA3 ITGA2 PLAUR CCL20 SPARCL1 CFH GLRX RBP4 TM4SF13 F2RL1 IRF8 NRP1 HSD11B1 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM EPHX2 ALDH8A1 FADS2 ABCD2 CROT NPC1 ABCA2 KLF1 ATXN1 HEL-S-53e MLYCD SLC67A1 AQP9 ACSL1 HEL-S-182mP FDXR ACSL5 PRDX5 LCK IDI1 DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 RXRA NR1H4 SULT2B1 PECR SLC23A2 SLC35B2 SLC27A2 SLC23A1 CYP46A1 HEL111 NR3C2 PEX26 OPTN LONP2 NUDT12 ABCG8 ISOC1 DIO1 PIPOX HEL-S-26 CH25H GNPAT SOAT2 RBP1 PEX11G LIPE ABCG4 SLC27A5 HAO1 PHYH ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 ABCA3 SULT1B1 AMACR PXMP2 SLCO1A2 ABCD3 TFCP2L1 ALDH9A1 LOC51064 ABCD1 CYP7B1 PEX7 PEX6 EFHC1 CYP27A1 AGXT SLC29A1 PAOX AKR1D1 HSD17B6 CYP7A1 GCLM GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 NR1i2 BBOX1 HEL-S-44 PEX12 CYP8B1 PEX13 NEDD4 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 PSMC4 HEL-S-276 RPL34 PSMB2 PWP1 RPL6 UBE2L3 EEF1B2 CCNA2 HDAC2 FBL PSMD7 SNRPD2 TRIM28 TFDP1 HNRPR RUVBL2 PSMD3 PSMD1 SNRPD3 MYC TXNL4A RPS10 CDC45 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 UBE2E1 TUFM CLNS1A SNRPG ERH SRSF7 SNRPA SET SLC25A3 GLO1 CSTF2 PCBP1 NOP16 KARS1 CBX3 MRPL23 SFRS3 LSM2 SRPK1 AIMP2 LSM7 UBA2 TOMM70 RNPS1 HNRNPC HSP90AB1 RPLP0 PTGES3 YWHAQ C1QBP DHX15 VDAC3 HNRPA3 AP3S1 MRPL9 NCBP1 VBP1 PABPC4 CAD GNL3 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 COX5A RPS2 CCT7 CCT4 NDUFAB1 RRM1 IFRD1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 TARDBP EIF4E EIF3B EIF4A1 RRP9 CDC20 RFC4 CDK4 CDK2 NHP2 HPRT1 NOLC1 ORC2 IARS PA2G4 EIF2S1 APEX1 HNRNPD HEL-S-97n NPM1 XPOT EIF3J ABCE1 EIF3D NCBP2 CTPS1 GOT2 HEL-S-133P MCM5 MCM6 MCM2 EIF2S2 PCNA COPS5 EPRS1 TRA2B TYMS POLD2 USP1 PSMA4 CANX H2AZ1 NOP56 RANBP1 ETF1 HSPD1 DUT HEL-S-69p RPL18 PSMC6 DEK IMPDH2 MCM7 HEL-S-68p HEL2 RAN MAD2L1 SNRPD1 SMARCC1 PSMA2 PRDX3 PHB2 CYC1 HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN TENT5C MX1 KRT13 SERPINB2 EGF GP1BA PTGFR ZC2HC1C PKP1 ATP6V1B1 EDN2 MEFV CD40LG PNMT FGF22 CLSTN3 ARHGDIG IRS4 PARK2 KRT1 NUDT11 KLK8 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 DCC PDK2 CPA2 KRT4 SELENOP RYR1 ENTPD7 UGT2B17 CDKAL1 HEL-S-79 KRT5 SOX10 THNSL2 EDAR SCN10A HEL-S-75 CLPS KCNQ2 SIDT1 CALCB CPB1 TNNI3 KCNE2 SHOX2 ZBTB16 CACNA1F MACROH2A2 SLC5A5 HSD11B2 FGGY KCNMB1 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B BARD1 DTNB AMBN HTR1D HTR1B FGF16 AKR1B10 IFNG IL5 TG GDNF BTG2 MYH7 STAG3 ARPP-21 CYP11B2 KLHDC8A CHRNG CD80 PCDHB1 TLX1 CD207 CACNG1 CPEB3 ZFP112 GPR19 RYR2 TENM2 IL12B MAST3 IGFBP2 SERPINA10 OXT SLC6A3 SKIL LFNG CCR8 EFHD1 LYPD3 INSL5 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 HEL-S-20 SPHK2 FSHB NGB COPZ2 SNN PAX3 TEX15 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT GTF3C5 TFF2 CELSR2 CLDN16 ITGB1BP2 CDH16 IFI44L GPRC5C SLC29A3 SPRR3 ITIH3 SMPX NPY4R PLAG1 ALOX12B CCDC106 ABCB11 NR1A2 P2RY4 RSAD2 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 EDN1 MYO15A SCGB1A1 YPEL1 PAX4 ASB7 MAGIX PDCD1 RGS11 SGK1 COQ8A BRDT HNF1A ABCG4 FGFR3 SYNPO TFCP2L1 IDUA CNTFR HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME EPHX2 CRAT ABCB1 ABCD2 BCL10 HRAS TOP2A ABCC5 DHRS3 FADS1 FDPS ECI2 CTPS1 ATXN1 HEL-S-53e MLYCD PBR ACOT8 ACSL1 ACSL5 PRDX5 CADM1 SLC25A4 PABPC1 IDI1 SULT2B1 RDH11 HAO2 SLC23A2 SLC35B2 SLC27A2 HEL111 VPS4B DHCR24 CNBP PEX14 LONP2 ERCC1 SCGB1A1 ABCC8 ISOC1 DIO1 HEL-S-26 GNPAT RETSAT DKFZp667O1614 IDE STS NUDT19 PEX2 NR3A2 SLC25A17 PEX5 CRABP2 SEMA3C CTBP1 ABCB4 CRABP1 PEX11B CACNA1B SMARCC1 ABCB9 ELOVL5 CLN8 ABCD3 FIS1 FACL4 UGT2B17 ALDH9A1 SIAH1 LOC51064 CDK7 ABCD1 MSH2 DLG4 FABP6 ALB ACOX1 PEX6 EHHADH CLN6 HSD17B4 RXRG HSD17B11 HSD3B7 HSD11B2 NR1i2 HEL-S-44 MVP HMGCL PEX13 HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 HK2 MRTO4 HSPD1 SRM MPHOSPH10 PLK4 PA2G4 TMEM97 PLK1 EXOSC5 DUSP2 MYC NPM1 RRP9 MYBBP1A NOP16 CBX3 CDK4 AIMP2 RCL1 MCM5 NIP7 NOP2 PPAN DCTPP1 NOC4L RABEPK WDR43 UNG TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 SORD NOLC1 IMP4 GNL3 TFB2M PPRC1 SLC19A1 BYSL LAS1L GRWD1 NOP56 NDUFAF4 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING PSENEN NOTCH3 SAP30 TCF7L2 MAML2 HES1 FBXW11 FZD7 DTX1 CCND1 DTX2 PSEN2 DTX4 ST3GAL6 NR1C2 SKP1 FZD5 NOTCH1 RBX1 FZD1 LFNG NOTCH2 PRKCA KAT2A HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY PFKP ATOX1 HEL-S-112 HEL-S-128m SRXN1 MGST1 MPO NDUFA6 ERCC2 PTPA HHEX HEL-S-97n SBNO2 MBP CDKN2D EGLN2 TXNRD2 SELS GLRX2 OXSR1 TXN IPCEF1 SCAF4 JUNB PRNP MSRA FES FTL LAMTOR5 HEL-S-2a GLRX NQO1 GCLC GPX4 GCLM GPX3 ABCC1 HEL-S-44 HEL-75 NDUFB4 HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 MSX1 ALAS1 PDLIM3 ATP6V1C1 ATP6V1F TMBIM6 GLS HTR7 STARD3 HLA-F MAPK8IP2 CDC34 CHKA MRPL23 POLG2 HEL-76 PRPF3 SELENOW TYRO3 NPTXR UROD CHRNA5 CYB5R1 NKX2-5 NPTX2 CCND3 KLHDC3 GGH RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 CDO1 ONECUT1 CLTB ARRB2 SPR SLC25A4 HYAL2 SIGMAR1 NUP58 TGFBRAP1 DDX21 MAOA WIZ SQSTM1 CLCN2 TAP1 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 HSPA2 PLCL1 CDC5L CCK GRINA ATF3 CYP1A1 POLE3 AP2S1 YKT6 RRAD TFRC RFC4 PARP2 HMOX1 CDK2 TACR3 CCNE1 TARS1 SHOX2 EPHX1 ASNS BMP2 ENO2 BTG2 ABCB1 BTG1 FKBP4 CEBPG TCHH FEN1 H2AX CDKN1C FURIN IGFBP2 JUNB PPT1 IL6ST FOS CNP BTG3 RPN1 HEL-S-94n CASP3 COL2A1 AQP3 NFKBIA GPX3 IRF1 POLR2H IL6 OLFM1 SLC6A8 CYB5B BAK1 PPIF CXCL2 PDAP1 CDKN2B hEMMPRIN C4BPB DGAT1 HEL-S-87p DLG4 RET RHOB GAL SLC6A12 MMP14 TUBA4A SULT1A1 GRPEL1 FOSB LYN AMD1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING MAFF NT5E SPP1 GBP4 MUC1 LRIG1 MYC IGF1R PTCH1 HEL-S-21 DHRS3 HEL-76 CD81 ENO3 RORA PLSCR1 CCND3 CCND2 GABARAPL1 AHR SERPINC1 ANXA4 CYFIP1 GUCY1B1 GPR65 IKZF2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 SELL ENPP1 SLC39A8 IL1R2 TNFRSF4 SHE WLS SYNGR2 PRKCH S100A1 SWAP70 PRNP IL3RA FLT3LG LTB ADAM19 TNFRSF21 TWSG1 MAPKAPK2 GPR83 SOCS1 AGER SOCS2 CD79B IL10 PENK PLPP1 MAP6 SNX9 ICOS ARL4A POU2F1 TNFRSF1B IL2RA CCNE1 HOPX DRC1 CDC42SE2 PHTF2 CTSZ PTH1R ITGAE CD48 MYO1E GLIPR2 NCS1 PTGER2 NFKBIZ SH3BGRL2 CTLA4 SIAT4C LIF CCR4 BATF3 TNFRSF18 CKAP4 SERPINB6 BMP2 CDCP1 PTRH2 COL6A1 IL13 TLR7 ITGA6 IRF6 SMPDL3A IFITM3 MXD1 PLEC AHNAK CST7 COCH RRAGD IL1RL1 IL10RA PLAGL1 TNFSF10 LRRC8C ABCB1 DCPS CD83 PRAF2 CSF2 SPRY4 CSF1 HUWE1 P2RX4 ARHH TTC39B IL2RB SYT11 SNX14 ETFBKMT IL18R1 CDKN1C F2RL2 BMPR2 EEF1AKMT1 APLP1 FURIN MAP3K8 DENND5A MYO1C PHLDA1 HEL-S-66 IGF2R HIPK2 BHLHB2 BCL2L1 ETV4 CASP3 UMPS TNFRSF9 P4HA1 GPX4 RGS16 IFNGR1 PNP EMP1 GADD45B CISH HK2 SLC2A3 TRAF1 XBP1 ITGAV GATA1 SELP PIM1 NFIL3 AMACR ADFP BCL2 RHOB NOP2 KLF6 IRF4 BATF TIAM1 CDC6 CD44 IRF8 NRP1 UCK2 FGL2 HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION MAFF SERPINA1 CPQ PLEK HRG CTSO CTSH OLR1 SERPINB2 GP1BA F3 F8 RAC1 CD9 MMP15 F11 C1QA C1S C1R THBD SERPINC1 TMPRSS6 PLG FYN F10 HEL-S-62p ISCU APOC1 CFD KLKB1 KLF7 S100A1 KLK8 A2M PF4 MEP1A CAPN5 MBL2 SPARC SIRT2 MMP9 PLAT CLU COMP F2RL2 GDA MASP2 FURIN CPB2 PEF1 CFI PROZ GNG12 LEFTY2 TF PROC F13B ARF4 C8A RAA1 DUSP14 C8G VWF CTSK FGA MMP7 F9 DCT HEL-S-52 CASP9 MMP10 CRIP2 CPN1 PECAM1 P2RY1 SH2B2 MMP11 HEL-S-41 HTRA1 APOC3 APOC2 MSRB2 ANXA1 USP11 F2 TFPI2 BMP1 FBN1 ITGB3 TIMP3 NR2A1 TIMP1 LAMP2 PROS1 ITGA2 ADAM9 MMP2 SERPING1 MMP3 CFH C2 PRSS23 DPP4 MMP14 C9 S100A13 THBS1 GP9 GNB2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 PLCG1 CCL19 MAPK3 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 FOXO3A CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 MET SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 LCK TRAF3 CSNK2B TCP1 BTK MET PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF FYN RAF1 CRK MET RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH PTK2B GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 POFUT1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 LEF1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY EGFR PERP TP53INP1 SPP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 FAS BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B MET HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 ATM TOP3A XRCC3 RPA1 FANCA MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG BRCA1 FANCF RAD50 FANCD2 UBE2T RAD17 RAD1 FAN1 ATR TOPBP1 CENPS RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY NFATC2 PRKCA NFATC1 CABIN1 PPP3CA PPP3CC CAPNS1 CAPNS2 CALM1 MEF2D HDAC1 HDAC2 EP300 PRKCB BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 EP300 MED1 RXRA CREBBP LPL PPARG PPARGC1A PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML YAP1 HEL2 SHC1 ZFYVE9 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 RPS6KB1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 GRB2 ITCH SOS1 ZFYVE16 ARHA BAMBI STRAP CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY ACTN1 FZD7 PRKCA FGF7B F2 NUDT16L1 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY1 LPAR4 ADCY8 ADCY6 CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 ITGAV PIP5K1C TLN1 CRK NECTIN3 NECTIN2 PIK3CA NECTIN1 CTNNB1 FARP2 PIK3R1 SRC ITGB3 PTPRM IQGAP1 F11R CLDN1 VAV2 CDC42 AFDN RAC1 RAP1A CTNNA1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY TACC1 KIF20A tmp_locus_29 HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY KNS2 RALA CLTC CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA CTNNB1 ITGB1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY SMAD2 SMAD4 MAP2K1 TGFB1 MAPK3 TGFBR1 TGFBR2 MAP3K7IP1 APC ZFYVE9 EP300 MAP3K7 SKIL CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY EGFR PRKCA SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 RPS6KB1 LAMC2 PIK3CA MST1R LAMC1 RXRB ERBB3 YWHAQ GRB2 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 ITGB1 EGF LAMB2 MET LAMA1 LAMB1 LAMA3 YWHAZ IL1A PMP22 CD9 BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 SHC1 TF PIK3R1 SYNJ1 SRC KRAS CDC42 RAC1 HEL-S-31 RAP1A MAP2K1 MAPK3 CRK PIK3CA GRB2 HRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY PIN1 SKP2 CDKN2A AXIN1 KAT2A MAX MYC PML TRRAP GSK3B TAF12 FBXW7 PPP2CA TAF10 TAF9 ACTL6A PPP2R5A SUPT7L KAT5 RUVBL2 RUVBL1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 ADRB2 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p NPM1 ADFP TFF3 ABCG2 ENG HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 JUN VEGFA PFKL COPS5 SP1 LEP ID2 TERT SMAD4 CXCR4 EP300 ABCB1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB PIK3R1 NFKBIA SRC CSNK2B ARRB2 REL RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY ITGB1 LYN SELP ACTA1 EPHA4 FYN EPHB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY EGFR BTC TGFA NRG3 NRG4 ERBB4 HBEGF ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY PRKCA JUN ADCY9 EDNRB GNAL MAPK1 PRKCE ADCY3 ADCY1 ADCY8 MAPK14 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 CRK GNAZ GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 EDN2 KPG_011 PTK2B HRAS TRPC6 ARHA MAP2K2 PRKCH EDN3 GNAO1 EDN1 SLC9A3 FOS PLCB3 COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY XDH TNF NFKB1 RELA GPX1 HEL-75 HEL-S-64p CXCL8 HEL-S-44 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL10 IFNA1 IL2 IFNB1 IL15 IL13 IL18 IL16 IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAP2K6 TNF NFKB1 JUN MAPK8 MAP2K3 ATF1 MAPK14 MAP4K2 IKBKB MAP2K4 NFKBIA MAP3K1 CHUK CRADD RELA TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY EGLN2 CDKN2A HIF3A EGLN1 RBX1 EGLN3 OS9 ARD1A VHL ELOC HIF1AN COPS5 HIF1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY GRB7 TNF PXN F2 PAK1 PLD2 MAPK1 NCK1 MAPK14 SHC1 PIK3R1 AGTR1 RELA FYN RAC1 PTPN11 MAPK3 NFKB1 CRK RPS6KB1 PIK3CA FOXO1 MAPK8 GRB14 ANGPT4 STAT5B GRB2 ANGPT2 ANGPT1 MMP2 BMX ELF1 CDKN1A ELF2 FES ITGB1 PLG FGF2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 ATM GADD45A YWHAQ CDKN1A CDKN2D PRKDC PLK1 BRCA1 MYT1 CDC25B WEE1 MDM2 CDC34 CHEK2 EP300 RPS6KA1 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY MAP2K1 MAPK3 IL3 STAT5B GRB2 SOS1 HRAS SHC1 FOS RAF1 CSF2RB IL3RA PTPN6 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRF1 DAB2IP PRKCA RASAL1 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 PLCE1 NF1 RIN1 NRAS SOS2 RRAS GRB2 SOS1 PRKCE HRAS KRAS PRKCZ PRKCB RASGRF2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAP2K1 MAPK3 IL2 LCK IL2RA JUN MAPK8 IL2RB STAT5B GRB2 SOS1 CSNK2A1 HRAS SYK SHC1 FOS IL2RG RAF1 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS JUN CHRNA1 DOCK7 PIK3CD MAPK1 PIK3R3 PIK3R2 MAPK9 CHRNE BAD SHC1 STAT3 PIK3R1 NFATC4 SRC RNF41 KRAS MAPK10 NF2 CDC42 NRG1 RAC1 NRG2 MAP2K1 PTPN11 MAPK3 MTOR PIK3CA MAPK8 ERBB3 GRB2 ERBB2 SOS1 HRAS MAP2K2 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY DDX5 CCNB1 CDC2 PRKACG PPP2CA PRKAG1 AKAP8 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY CCNA2 IL4 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 BCL2L1 ELF1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY PDGFRA RAPGEF1 CAV3 ITGAV SHB CRKL SHF CRK PLCG1 PIK3CA JUN GRB2 SOS1 IFNG CSNK2A1 SHC1 PIK3R1 FOS JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 CRKL LRPAP1 VLDLR PIK3CA CBL LRP8 GRIN2B MAPK8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 CDK5R1 ITGB1 PAFAH1B1 PIK3R1 GSK3B FYN RAP1A BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 MAX RPS6KA5 MYC MAPK14 SHC1 MAP2K4 MAP3K1 TRADD TRAF2 MAP3K7 CDC42 RIPK1 RAC1 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS ATF2 HSPB2-C11orf52 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 MYT1 CDC25B WEE1 CDK2 ATM CDK4 CHEK1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY DOCK1 PAK1 JUN MAPK1 STAT3 PIK3R1 ACTA1 RAP1A PTEN RAPGEF1 MAP2K1 PTPN11 MAPK3 CRKL CRK PIK3CA MAPK8 GRB2 SOS1 PTK2B HRAS MAP2K2 ITGB1 MET FOS HGF RAF1 MAP4K1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 COL4A6 COL4A5 REN AGTR2 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 PRKAR1B CDC2 PRKAR1A PRKACG TSG101 CD3G CD3E CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY MAP2K6 RALA LCK PAK1 MAP3K7IP1 MAP2K3 MAPK14 MAP2K4 BLK SRC YES1 LYN RALB DUSP8 DUSP16 c-fgr MAPK11 FYN CDC42 DUSP10 TRAF6 RIPK1 RAC1 MAP3K12 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TNFRSF9 IL2 NFKB1 IL4 JUN MAPK8 IFNG MAPK14 IKBKB ATF2 NFKBIA MAP3K1 CHUK MAP3K5 RELA TRAF2 TNLG5A BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY WASL WASF1 ACTA1 CDC42 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 NF1 GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 TFRC UCP2 NKX2-1 ACADM FOXA1 PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 NR2A1 PDX1 HNF1A IGFBP1 CPT1C G6PC1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL10 IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 SP1 CCL17 SOCS5 EGR2 HMGA1 PARP14 MAPK14 COL1A1 SHC1 CD40LG PIK3R1 CCL26 IL2RG BCL6 SELP MYB JAK3 JAK1 LTA MTOR RPS6KB1 PIK3CA CBL GRB2 BCL2L1 COL1A2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY ROCK1 CTNND1 FGFR1 PIK3R1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CDC42 CAMK2G RAC1 HEL-S-61 PTPN1 CTNNA1 JUP GAP43 PTPN11 FER PIP5K1C MYL2 DAGLB MAPRE1 PLCG1 AXIN1 PIK3CA MAPK8 ARHA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ASPH VHL HEL-S-133P EPO JUN CREB1 EP300 VEGFA COPS5 HIF1A PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY MAPK3 CRK FLT4 VEGFC PIK3CA VEGFD CREB1 GRB2 ITGA4 MAPK1 SOS1 ITGA2 ITGA1 MAPK14 COL1A1 ITGB1 SHC1 MAP2K4 PIK3R1 COL1A2 MAPK11 RPS6KA1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CDK5R1 GSK3B CAPNS1 CAPNS2 PPP2CA APP CDK5 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD7 FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 DKK1 ROR2 WNT1 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY KCNA2 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS MAPK1 HRAS MAP2K2 ADCY1 RAF1 c-fgr PLCB1 KCNA1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 GRK5 PLD2 SNCA TH STUB1 MAPK1 HEL-117 CSNK2A1 SYK BAD BLK SRC YES1 LYN c-fgr FYN MAPK3 LCK FKBP1A PTK2B PPP2R5D PLCB2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY PDGFRA MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 PDGFA CSNK2A1 HRAS SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NR1i1 NCOA1 MED1 HDAC1 RXRA PRMT1 SMARCE1 SMARCD1 SUPT16H SMARCC1 SMARCA4 SMARCC2 CARM1 BAZ1B ARID1A NCOR1 CHAF1A TSC2 ACTL6A EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF IL1A SELP CSF3 ITGAM SELPLG SELL PECAM1 ICAM2 CXCL8 IFNG PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY ROCK1 TNF MMP9 THY1 IL6 BLK SRC PRKCZ YES1 CTGF LYN SELP ITGAM SELPLG c-fgr FYN PLAT RAP1A HMGB1 AGER APOB JAM2 JAM3 TLN1 PLAUR NFKB1 MYH2 LPA MST1R LCK MMP2 ARHA PLG BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY MAPK3 PRKAR1B PRKAR1A PRKACG IGF1 PIK3CA IGF1R KITLG IL3 KIT BCL2 MAPK1 ADCY1 BAD PIK3R1 BAX RPS6KA1 CSF2RB IL3RA BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY ITGB1 SELL SELE PECAM1 CD44 ITGA4 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 CREBBP SKP2 MAP2K1 CDKN2A CDC2 LAMA4 CDK2 GSK3A CENPA ONECUT1 MMP2 FOXM1 RB1 AURKB CENPB CKS1B CCNB2 CCND1 NEK2 PLK1 NFATC3 FOS H2BC1 ETV5 CDC25B CENPF GAS1 CHEK2 EP300 CDK4 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 CDKN2A PIK3R1 PIK3CA MDM2 POLR1A POLR1C POLR1D TWIST1 RAC1 TBX2 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY EGFR PIK3R5 ROCK1 GNA13 PRKCA GNG2 ADRBK1 TBXA2R PTGDR PTGIR NHERF1 VCAM1 RAB11A GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK SRC ARRB2 PRKCZ YES1 LYN c-fgr FYN MAPK11 RAC1 GNA14 LCK GNA15 SELE GNA11 ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PRKCB PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 MAPK1 PIK3R3 WWOX PIK3R2 CBFA2T3 PRLR YAP1 ADAM17 DLG4 SHC1 NEDD4 PIK3R1 NCOR1 MDM2 FYN NRG1 NRG2 EREG BTC NRG3 MAPK3 NRG4 ERBB4 HBEGF WWP1 PIK3CA GRIN2B STAT5B GRB2 ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PRKCA MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA CREB1 GRB2 RPS6KA5 MAPK1 SOS1 HRAS ADCY1 MAPK14 PIK3R1 RPS6KA1 RAC1 PRKCB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PRKCA GNG2 RAB11A GNB1 PLD2 IL8RB PPP2R1A ARRB2 VASP LYN ELMO1 PPP2CA DOCK2 RAB5A c-fgr RAB7A PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 PRKCB BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY DCX DNCL1 NDEL1 LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAP2K1 MAPK3 EPOR PLCG1 EPO JUN MAPK8 STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 FOS RAF1 PTPN6 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY ADAM17 NRG3 PRKCA ERBB4 PSEN1 NRG2 PRKCB BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ACTN1 ITGB1 TLN1 ACTN2 CAPNS1 ITGB3 EZR CAPNS2 SPTAN1 ACTA1 RAC1 ARHA PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY WASL JUN PIK3CD PIK3R3 PIK3R2 MAPK9 NCK1 BAD PIK3R1 MAP2K4 ARRB2 PRKCZ MAPK10 PARD6A FYN RAC1 PLCG1 PIK3CA PRKCI KIRREL1 MAPK8 CD2AP TJP1 NPHS1 GRB2 NPHS2 F2RL2 NCK2 TRPC6 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD2 THY1 CD3G CD3E CD3D PTPRC PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY KRT18 TNF MADD GAS2 CYCS BIRC2 BIRC3 MAP3K1 BAX CRADD TRADD TRAF2 ACTA1 PRF1 TNFRSF1A CASP2 RIPK1 PIDD1 CASP10 CASP6 SPTAN1 HEL113 APP BCL2 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 APAF1 LIMK1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY WASL ARPC1B ACTR3 ACTR2 PAX6 PAK1 TIAM1 ARHGEF7 IQGAP3 HEL-S-15 MAPK1 PRKCE HEL-S-47e HES5 PAK4 MAP2K3 SEPTIN2 APC LIMK2 TNK2 MAP2K4 BRAF SRC MAP3K1 ARPC4 GSK3B YES1 ARPC5 CDC42BPA IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 CTNNA1 MAP2K6 RASGRF1 JUN EXOC7 MAPK9 MAPK14 PIK3R1 PRKCZ PARD6A RAC1 MYL2 MAPK3 MTOR RPS6KB1 PIK3CA CBL MAPK8 F2RL2 HRAS MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2S2 PRKCA SUI1 EIF2S1 ELAVL1 EIF2S3 KDR PLCG1 FLT4 VHL EIF2B1 PIK3CA VEGFA HRAS SHC1 PIK3R1 EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX PRKCB HIF1A BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 FOXO4 PIK3CA GHR FOXO1 GH1 BAD IKBKB PIK3R1 CASP9 NFKBIA CHUK RELA PPP2CA FOXO3A TNFSF6 IKBKG BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB8A RAB11A ACTA1 RAB5A RAB2A RAB7A RAB1A RAB4A RAB6C RAB9A RAB27A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY ADCY1 FSHB FSHR CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY EGFR PSEN1 PSENEN SRC NCAN SDC3 CASK PTN MC4R POMC FYN APH1B AgRP CXCL8 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY FZR1 TACC1 DLGAP5 TDRD7 CKAP5 TACC3 AURKAIP1 AJUBA RAN PAK1 GADD45A ARHGEF7 NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA BRCA1 CDC25B PPP2R5D HCTP4 OAZ1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY MMP9 KAT2A E2F3 BAX TAF12 TAF10 ACTL6A SUPT7L KAT5 CREBBP RUVBL2 RUVBL1 NBN EIF2S1 TFRC ENO1 NPM1 NCL BIRC5 CCNB1 PMAIP1 HEL-S-133P EIF4A1 BMI1 PEG10 UBTF PIM1 RCC1 MAX HEL-S-162eP ID2 MYC CAD NME2 HMGA1 PTMAP7 BCAT1 SHMT1 IREB2 RPL11 CDCA7 MTDH HSPD1 PRDX3 TERT MDIG CCND2 MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 SMAD4 FOSL1 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 EP300 TK1 CDK4 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY EGFR MAP2K1 MAPK3 ERBB4 PIK3CA GRIP1 IL6 ERBB3 GRB2 IL6ST ERBB2 MAPK1 SOS1 IL6R HRAS SHC1 STAT3 CARM1 PIK3R1 RAF1 EP300 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNH PTCH1 CCNB1 MNAT1 CDC2 CDC25B CDK7 SHH BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY MAP2K1 PRKCA MAPK3 F2 PLCG1 CALM1 MAPK8 AGTR2 GNA11 GRB2 CDK5 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAPK14 SHC1 STAT3 KNG1 STAT1 RAF1 FYN PRKCB PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN CREB1 TH YWHAQ HEL-S-1 YWHAG HEL2 MAPK14 MAPKAPK3 TCF3 YWHAZ CDC25B HEL-S-102 TSC2 RAF1 MAPK11 MAPKAPK2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY CYLD TNF MADD TNIK SQSTM1 NSMAF BIRC2 BIRC3 MAP2K3 ADAM17 IKBKB MAP4K2 MAP3K1 PRKCZ CHUK RELA TRADD TRAF2 SMPD1 MAP3K7 TNFRSF1A RIPK1 HEL-S-31 IKBKG NFKB1 PRKCI MAP3K7IP1 CASP8 NRK MAP3K5 TNFAIP3 TXN SMPD2 STAT1 BAG4 FADD RFFL MAP4K3 TRAF1 TNFRSF1B BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PRKCA DLG4 PRKAR1B PPP3CA PRKAR1A GRIN1 PPP3CC PRKACG CALM1 GRIN2B PRKCB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD2 CD8A THY1 CD3G CD3E CD3D PTPRC PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY SMAD2 TGFB1 PRNP SERPINC1 PLA2G2A TGFBR1 LCK APP CRIPTO TGFBR2 FGFR1 VEGFA GPC1 SLIT2 BLK SRC LAMA1 YES1 LYN c-fgr FYN NRG1 FGF2 FLT1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAP2K1 MAPK3 PLCG1 PIK3CA JUN MAPK8 NGFR GRB2 NGF SOS1 DPM2 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNG2 CCL11 GNB1 NRAS PIK3CD MAPK1 PIK3R3 CXCL9 PIK3R2 MAPKAP1 CXCL13 MAP2K3 CXCR3 MAPK14 MLST8 PIK3R1 RICTOR SRC CXCL10 KRAS CXCL11 PF4 MAPK11 MAP2K6 MAP2K1 MAPK3 PDPK1 GNAZ MTOR GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 RAF1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY PRKCA SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 GRB2 SOS1 NGF DPM2 PRKCB HRAS BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM CHEK2 ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PRKCA PTPN11 MAPK3 PDPK1 PLCG1 PIK3CA CBL VEGFA CD2AP MAPK1 NCK1 PIK3R1 NRP1 SHC2 NRP2 VEGFB FLT1 PRKCB HIF1A BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFATC2 NFATC1 PRKAR1B NFKB1 PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 EGR2 MYC NFKBIA MAP3K1 CHUK RELA VIPR2 VIP PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY NRAS PIM1 MAPK1 SYK SHC1 IKBKB STAT3 PIK3R1 KRAS LYN CSF2 CSF2RA CCL2 MAP2K1 PTPN11 MAPK3 CISH GAB2 OSM IRF8 PRKACG PIK3CA STAT5B GRB2 SOS1 HRAS MAP2K2 FOS YWHAZ STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY KCNA2 ADCY1 KCNA3 ADRBK1 GNAS NR1C1 AP2A1 AP2M1 PLCB1 KCNA1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EGFR PRKCA NFKB1 PLCG1 ADAM12 EDNRA JUN AGTR2 EDNRB ARHA MYC HRAS EGF EDN1 FOS RELA PRKCB PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY NFATC2 ROCK1 FZD7 PPARG MAPK9 CAMK2A ARRB2 PRKCZ YES1 MAPK10 MAP3K7 CDC42 RAC1 NLK DVL1 MAPK8 DVL2 DVL3 FZD2 FLNA FZD5 MAP3K7IP1 SETDB1 CSNK1A1 ARHA DAAM1 ROR2 CTHRC1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAP2K6 IL18 JUN MAPK8 CD3G CD3E CD3D IFNG TYK2 STAT4 MAPK14 CXCR3 CCR5 IL12RB1 IL18R1 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 SKP2 CKS1B CDKN1B RBX1 NEDD8 UBE2M SKP1 TFDP1 CDK2 CCNE1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF NFKB1 IKBKB NFKBIA CHUK RELA TRADD EP300 TNFRSF1A FADD CREBBP TRAF6 RIPK1 IKBKG TNFRSF1B PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY EGFR GULP1 EFNA1 PXN ACAP2 ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 ARF6 GNA14 GNA15 GNA11 EGF MET HGF ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 ARAP2 IPCEF1 EPHA2 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF TGFB1 ABCA1 THRA NR1H2 NR1C1 NR1H4 RPS6KB1 NR1H3 NR1i1 NR1C2 NR1B3 NCOA1 NR1A2 RXRB MED1 NCOR2 BCL2 RXRA FAM120B RARA RARB PPARG RXRG PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY CYLD PRKCA TNF NFKB1 BIRC2 RAN ATM RIPK2 UBE2D3 BCL10 NOD2 IKBKB ERC1 NFKBIA CHUK TNFAIP3 RELA TNFRSF1A TRAF6 IKBKG PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY SQSTM1 JUN IKBKB ERC1 HEL-S-71 PIK3R1 IL1RN PRKCZ IRAK1 CHUK RELA TICAM2 IL1R1 IL1R2 IRAK3 MAP3K7 IRAK4 IL1B TRAF6 UBE2V1 IKBKG MYD88 MAP2K6 NFKB1 PIK3CA PRKCI MAPK8 MAP3K7IP1 IL1A BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY NPPA CORIN GNAS PIK3R1 NFKB1 NR3C1 PIK3CA RELA CALM1 ADRB2 ANXA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF5 ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 ARHA VAV3 ARHGEF2 ARHGEF10 CDKN1B FARP1 ARHGEF12 ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 ARHGDIB MYO9B ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADCY1 CFTR PRKAR1B PRKAR1A NHERF1 PRKACG EZR ADRB2 BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY KHDRBS1 MAPK3 CDC2 MAPK1 HRAS PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PLA2G7 KATNA1 DYNC1H1 NUDC DYNLT1 HEL-S-303 CDK5R2 CSNK2A1 HEL2 IQGAP1 CDC42 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA CDK5R1 PAFAH1B1 PPP2R5D BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK3 NFKB1 PIK3CA TFDP1 CDK2 PAK1 CCNE1 MAPK1 ARHA HRAS RB1 CDKN1A CDKN1B IKBKB CCND1 PIK3R1 NFKBIA CHUK RELA RAF1 CDK6 RAC1 CDK4 IKBKG PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY SPP1 MMP9 ROCK2 JUN PIP5K1A HEL-S-28 MAPK1 SYK PIK3R1 NFKBIA MAP3K1 ITGB3 CHUK RELA CDC42 RAC1 MAP3K14 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 CD44 PTK2B MMP2 ARHA VAV3 FOS PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 RRAD STXBP4 YAP1 DLX5 DLX6 TBXT HELLS GPX2 GSK3B TCF7L1 ADRM1 FBXW7 KRT5 MDM2 POU2F2 RUNX1 PPP2R5A FOSL2 BRCA2 NRG1 AXL FASN KRT14 RAB38 HES1 ADA CDKN2A CEBPD BDKRB2 WWP1 ATM ITCH MRE11A CCNB2 TP63 IL1A PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY EGFR CASR FMN1 ZYX PLCG1 CTNND1 AJUBA PIK3CA PIP5K1A ARHA CTNNB1 PIK3R1 SRC VASP FYN RAC1 JUP CTNNA1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY TGFB1 IL2 CCR1 IFNGR1 IFNGR2 CCL4 CCL3 IL4 CCR7 CCR4 CCR3 IL5 IFNG CXCR3 CCR5 CD40LG IL12RB1 IL18R1 CXCR4 CSF2 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 MAPK1 IFNG STAT3 CAMK2A PIK3R1 MAP3K1 CAMK2G IL1B CREBBP RAP1A JAK1 RAPGEF1 MAP2K1 PTPN11 CEBPB MAPK3 CRKL IFNGR1 MTOR PIK3CA CBL CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL COL4A2 ENPP1 SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 FGA KNG1 CD40LG SPON2 F10 HEL-S-62p ICAM3 GP1BA ITGAM ICAM4 F11R HEL-S-78p CYR61 PROC ICAM2 FCGR2A PLAT ITGAX TGFBI BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 CDK2 ATM GADD45A CCNE1 BCL2 RB1 CDKN1A CCND1 PCNA BAX MDM2 CDK4 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL2RG RPS6KB1 IL4 GRB2 IRS1 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A2 AAG1 EIF4A1 EIF4G1 EIF4E EIF3A BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK14 MAPK3 DUSP4 DUSP2 DUSP9 DUSP8 MAPK8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY FOSL1 IFNB1 NFKB1 MAPK8 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IRF9 IFNAR1 FOS RELA FOSL2 TRAF6 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL10 IFNA1 IFNB1 IL13 IL4 IL3 IL5 IFNG CD40 CD2 CD5 CD7 TLR7 CD33 ITGAX CSF2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNAT2 RDH12 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 ARR3 GNGT2 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY SMAD4 AXIN1 NLK NR1C2 DVL1 FZD1 CTBP1 HDAC1 FRAT1 MAP3K7IP1 BTRC CSNK2A1 MYC APC HNF1A CTNNB1 CCND1 GSK3B PPP2CA WIF1 MAP3K7 WNT1 CREBBP PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK1 GNA13 PRKCA GNG2 F2 GNB1 ROCK2 ARHGEF1 HEL-S-47e PIK3R1 VASP MYL2 ZYX GNAZ GNAI3 GNAI1 PIK3CA GNA14 GNA15 GNA11 SNX1 SNX2 F2RL2 TRPC6 F2R ARHA PKN1 GNAO1 PLCB3 PLCB1 PLCB2 PRKCB BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAR1B GNAS PRKAR1A PRKACG ADCY1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 IL2 IL4 CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY SH3GL2 HGS AKT1S1 PXN NUMB WASL ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PAK1 RANBP10 MUC20 MAPK1 PAK4 APC NCK1 MLST8 MAP2K4 SRC MAP3K1 CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A RAC1 EIF4E PTPN1 ARF6 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PDPK1 PLCG1 MTOR SNAI1 PIK3CA PRKCI CBL MAPK8 GRB2 SOS1 F2RL2 NCK2 HRAS ARHA MAP2K2 CTNNB1 MET RAF1 INPPL1 RPTOR DEPTOR BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUTF2 KPNA2 RAN NUP214 RANBP2 NUP210 RCC1 NUP62 NUP153 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SFN SLC2A4 MAPKAP1 HEL2 AKT3 BAD MLST8 KPNA1 RICTOR TBC1D4 SRC GSK3B CHUK FOXO3A PDPK1 MTOR FOXO4 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 CDKN1A YWHAG CDKN1B PRKDC CASP9 MAP3K5 YWHAZ RAF1 BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY MAPK14 CD36 FOS CASP3 JUN FYN THBS1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY EGFR MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS EGF SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNG2 GNB1 CREB1 MAPK1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG MAP2K1 MAPK3 GNAZ PLCG1 GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 FOS PLCB3 RAF1 PLCB1 PLCB2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY HDAC7 SIRT1 KAT2B EGR1 NCOA1 JUN HDAC1 RXRA SMARCE1 CEBPA SMARCC1 MAPK14 CARM1 MAP2K4 SRC GSK3B REL MDM2 KAT5 CREBBP TMPRSS2 MAP2K6 KLK3 HOXB13 NR2C2 ZMIZ2 TRIM24 NR3C1 KAT7 SRY SPDEF FOXO1 POU2F1 RXRB MAPK8 NR0B1 SENP1 APPBP2 PDE9A RXRG PKN1 EP300 GATA2 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY ROCK1 GNA13 GNG2 MYL2 F2 GNA14 GNB1 ROCK2 GNA15 GNA11 F2RL2 F2RL3 ARHA PLCB2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 HDAC1 HEL-S-130P HEL-S-162eP MBD3 GREB1 TUBA4A TUBA1A TUBA2 MTA3 HSPB2-C11orf52 HEL-S-102 SNAI2 HEL-S-87p BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGB1 SELP ITGAM SELL SELE PECAM1 CD44 ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY ACTN1 ROCK1 CAPNS1 CAPNS2 JUN MAPK1 SHC1 ACTA1 FYN RAP1A RAPGEF1 MAP2K1 MAPK3 CRKL ZYX TLN1 ACTN2 MAPK8 GRB2 SOS1 HRAS ARHA MAP2K2 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAFK PRKCA NFE2L2 HMOX1 JUN MAPK8 CREB1 MAPK1 MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFG PRKCB MAFF BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ZAP70 PRKAR1B PRKAR1A PRKACG LCK CD3G CD3E CD3D PTPRC ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CREBBP BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ROCK1 PRKCA GNA13 F2 PIK3CA ARHGEF1 PTK2B F2RL3 F2R ARHA ADCY1 PIK3R1 PPP1R12B PLCB1 MAP3K7 PRKCB BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY ABCA1 FABP6 LDLR NR0B2 NR1H4 NR1H3 RXRA BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY MDC1 ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A RFWD2 TERF2 HEL-S-71 RBBP8 H2AX MDM2 BLM KAT5 NBN ATM CTBP1 TOP3A HEL-S-1 MRE11A BRCA1 RAD50 FANCD2 TRIM28 RAD17 CHEK2 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 JUN NCOR2 HRAS HDAC5 CSF1R HDAC2 FOS CSF1 ETV3 E2F4 ETS2 SIN3B SIN3A BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY CTLA4 PTPN11 ICOS ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 ITK PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY HEL-S-42 INSR ASIP LNPEP SFN PPP1R3A SLC2A4 PRKCI GYS1 TRIP10 STX4A INS VAMP2 YWHAQ HEL-S-1 STXBP4 YWHAG HEL2 PPP1CC TBC1D4 GSK3B PRKCZ YWHAZ BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY TIMP3 MMP9 MMP14 TIMP1 MMP2 RECK HRAS TIMP4 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY SMAD2 CTDSP1 SMAD4 CTDSP2 KPNA2 CTDSPL MAPK3 MAP3K1 UBE2I NUP214 MAPK1 NUP153 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY BMP4 BMP2 BMPR1A APC GSK3B MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 TGFBR1 DVL1 TGFBR2 FZD1 TGFBR3 HNF1A CTNNB1 BMP10 ATF2 BMPR2 GATA4 NPPB DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C WNT1 RFC1 NOG BMP7 BMP5 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY NFATC2 MAP2K6 NFATC1 CABIN1 MAPK7 INSR PPP3CA MYOD1 PPP3CC AVP CAMK1 IGF1 PIK3CA CAMK1G IGF1R CALM1 MAPK14 HDAC5 PIK3R1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 TNF SUMO1 SP100 PAX3 PRAM1 RARA HRAS RB1 PML FAS TNFRSF1A CREBBP TNFSF6 TNFRSF1B PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD4 BMPR2 DKFZp781O1323 ACVR1 FKBP1A SMAD1 AMHR2 TLX2 SMAD9 AMH BMP7 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A2 PRKCA AAG1 MAPK3 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 GHR EIF4G1 MAPK1 PABPC1 PDK2 MAPK14 PIK3R1 IRS1 EIF4E PRKCB PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R5 ZAP70 NRAS PIK3CD PIK3R3 PIK3R2 SYK ARF1 DAPP1 BLNK PIK3R1 CYTH1 BLK SRC PLEKHA1 KRAS YES1 PLEKHA2 LYN BTK SGK1 LAT c-fgr ARF5 FYN PLCG2 FOXO3A RAC1 RAP1A ITK PTEN ARF6 PDPK1 PLCG1 PIK3CA LCK HRAS ARHA CYTH2 INPPL1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY ACO2 SDHA CS FH SUCLA2 HEL-S-32 OGDH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A SP1 EGR2 PML IKBKB GPX2 TP53I3 FAS CHUK BAX MDM2 DICER1 ADA SMARCD3 BBC3 CDKN2A OGG1 CABL1 ITGB4 NOC2L EVPL CLCA2 WWP1 FLOT2 NQO1 TFAP2C DST YWHAQ AEN SSRP1 ITCH DHRS3 SHH SERPINB5 TRAF4 MFGE8 CDKN1A FDXR TP63 PLK1 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 SMURF2 CDC2 SMURF1 SFN CDK2 CDK5 CDK7 CDK8 CCNB2 CDK3 TRIM25 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY SNAP25 CHRM1 STX1A CHRNA1 VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY FZR1 CENPU C13orf34 KIF20A CCNB1 TUBG1 CENPE STAG2 PRC1 NUDC GORASP1 KIZ SPC24 PAK1 TPT1 ROCK2 PPP2R1A PPP2CA CDC2 FBXW11 RAB1A ECT2 ARHA AURKA SGOL1 PLK1 ERCC6L CDC25B BUB1B KNTC2 WEE1 CDC14B CDC20 GOLGA2 HEL-S-80p FBXO5 INCENP HCTP4 CLSPN NINL PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 MYOD1 TFDP1 PAX3 CCNE1 CEBPA RBBP4 E2F2 E2F3 E2F4 TBP MAPK11 CREBBP CSF2 SKP2 CEBPB CDKN2A CEBPD CDK2 ELF1 CCND1 SPI1 SUV39H1 JUN AATF UBTF HDAC1 BRD2 SFTPD RUNX2 PPARG RBP2 ATF7 MAPK9 HDAC3 BGLAP MAPK14 SMARCA4 GSC CBX4 PPP2R3B TAF1 PPP2CA MDM2 CCND2 CDK6 CTBP1 RB1 CDKN1A CDKN1B ATF2 MET CCND3 RAF1 EP300 MEF2C CDK4 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 MYT1 CDC25B WEE1 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY SFN EGR1 NRAS CREB1 NGF HEL2 BAD SHC1 CAMK2A PIK3R1 CAMK4 SRC KRAS GSK3B AGAP2 NTRK1 TRPC3 TRPV1 FOXO3A PDPK1 PLCG1 PIK3CA YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PDGFRA PIK3R1 WASL PIK3CA PAK1 CDC42 RAC1 ARHA BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY HDAC5 PPP3CA CAMK4 PPP3CC NR1C1 CAMK1 SLC2A4 CAMK1G CALM1 ESRRA PPARGC1A PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PXN CRKL PDPK1 CRK RPS6KB1 PIK3CA IGF1R GRB2 SOS1 NCK2 HRAS HEL2 BAD SHC1 PIK3R1 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY FAS PRF1 CD3G HLA-A CD3E TNFSF6 B2M CD3D BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY PDGFRA EGFR MAP2K1 MAPK3 GNAS IGF1R NGFR GRB2 NGF RPS6KA5 MAPK1 SOS1 DPM2 MYC HRAS MAP2K2 ITGB1 SHC1 STAT3 PPP2CA RAF1 RPS6KA1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY GPD2 UQCRC1 SDHA SDHC SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 ZNF183 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY MAPK14 FBL GPT EIF4E NCL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY PRKCA MAPK3 CDC2 KAT2B NR1i1 NR1B3 NCOA1 RXRB MAPK8 RBP1 HDAC1 NCOR2 RXRA RARA MAPK1 CDK7 RARB CCNH RXRG HDAC3 MAPK14 MNAT1 EP300 CREBBP BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC PLCG1 CALM1 MARCKS SP1 SP3 CDKN1A NFATC4 NFATC3 PRKCB BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER1 PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 ALOX5 ALOX5AP PTGES PLCB1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY EGFR IGF2 GNA13 ADAM10 HGS ZBTB33 MEP1B GDNF RIN2 CTNND1 TIAM1 SRC IQGAP1 RAB5A CDH2 RAB7A FYN CDC42 RAC1 CREBBP PTPN1 CTNNA1 JUP ARF6 CABL1 IGF1R SNX1 HRAS CTNNB1 EGF MET CASP3 RET ROBO1 SLIT1 NTRK2 MMP7 BDNF PTPN6 MMP3 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY ADAM17 PSEN1 RBPJ FURIN NOTCH1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY EGFR ACTN1 ROCK1 EFNA1 CYFIP2 CTNND1 NCKAP1 AQP5 AQP3 LPP LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN CTNNA1 ARF6 PIP5K1C MYL2 ZYX NECTIN2 IGF1R STX4A ARHA CTNNB1 EGF MET HEL114 HGF EPHA2 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY HDAC9 PIAS2 HDAC6 SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL2 IFNGR1 IFNGR2 IL18 IL4 IL2RA IFNG CD40 CD40LG IL12RB1 NR1i2 IL18R1 IL12B IL12A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY NFKB1 MAPK8 MAPK14 CHUK TWEAK RELA TNFSF13 TRAF2 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 MAP3K14 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 BIRC2 CASP6 BIRC3 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 PRF1 LMNA DFFB CASP2 DFFA PARP1 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF IFNA1 IFNB1 JUN IL6 MAP2K3 MAPK14 IKBKB NFKBIA IL1RN MAP3K1 IRAK1 CHUK RELA IL1R1 IRAK3 MAP3K7 IL1B TRAF6 IRAK2 MYD88 MAP3K14 MAP2K6 TGFB1 NFKB1 MAPK8 MAP3K7IP1 IL1A BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFRA SPHK1 PRKCA S1PR1 ITGAV MAPK3 PIK3CA MAPK1 PDGFA ARHA ADCY1 PIK3R1 ITGB3 SMPD2 SMPD1 PLCB1 RAC1 SPHKAP PRKCB BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 HLA-DRB5 HLA-DRB4 TAP1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-A B2M BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY LDLR MBTPS1 MBTPS2 SREBF2 LIMA1 HMGCS1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD MAPK1 TNFRSF10C PIK3R3 PIK3R2 TNFRSF10B TNFRSF10A TNFRSF10D IKBKB PIK3R1 MAP2K4 MAP3K1 CHUK TRADD TRAF2 SMPD1 RIPK1 IKBKG MAPK3 CASP10 PIK3CA TNFSF10 DAP3 MAPK8 CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA IL1A IL1R1 TRADD TNFRSF1A FADD MAP3K7 TRAF6 RIPK1 IKBKG MYD88 TNFRSF1B MAP3K14 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 KAT2B NCOA1 TBP NCOR2 RXRA RARA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF5 ROCK1 MYL2 TLN1 ARHGAP5 ARHGAP4 ARHGEF1 OPHN1 PIP5K1A ARHGEF11 ARHA ARHGAP1 HEL114 STM7 PFN1 BAIAP2 PPP1R12B LIMK1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EGFR HGS TF EGF EEA1 TFRC RAB5A BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY EGFR MAP2K1 MAPK3 CBL GRB2 MAPK1 SOS1 HRAS EGF SHC1 SPRY4 RAF1 PTPRB SPRY2 SPRY1 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNA13 S1PR1 ITGAV MAPK3 GNAZ GNAI3 GNAI1 GNA14 VEGFA GNA15 GNA11 MAPK1 ARHA AKT3 GNAO1 SRC ITGB3 CXCR4 S1PR3 RAC1 FLT1 S1PR2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAP2K1 MAPK3 CRKL PIK3CA JUN MAPK8 STAT5B GRB2 SOS1 MYC HRAS BAD MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAP2K1 PRKCA MYL2 MAPK3 GNAS CCL11 ROCK2 CCR3 MAPK1 ARHA HRAS PPP1R12B RAF1 PLCB1 PRKCB LIMK1 PIK3C2G BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDT1 MCM7 ORC6 CDC6 ORC3 ORC2 MCM5 MCM6 MCM2 CDK2 KITLG CCNE1 MCM3 CDKN1B ORC1L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAP2K1 MAPK3 NSMAF NFKB1 AIFM1 MAPK8 BCL2 MAPK1 BAD MAP2K4 MAP3K1 CASP8 BAX RELA TRADD TRAF2 RAF1 SMPD1 TNFRSF1A FADD RIPK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY TYK2 IFNAR1 STAT2 IFNA1 IFNB1 STAT1 IFNAR2 IRF9 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF SIRT1 KAT2B RANBP2 HDAC9 HDAC6 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC1 MAX PPARG HDAC3 HDAC10 HDAC11 STAT3 CHD4 HDAC5 NFKBIA CHD3 MBD3L2 SMG5 RELA SIRT4 SIN3B SIRT5 SIN3A SIRT6 SIRT7 SIRT2 SIRT3 SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 NFKB1 MTA2 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY NFATC2 NFATC1 PPP3CA PPP3CC CALM1 JUN MAPK1 SYK SHC1 PIK3R1 MAP2K4 NFATC4 MAP3K1 LYN BTK MAP2K1 MAPK3 PLCG1 PIK3CA MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DOCK1 SQSTM1 DYNLT1 TIAM1 NRAS NGFR NGF MAPK1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 SHC1 STAT3 PIK3R1 PRKCZ ELMO1 RAC1 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PLCG1 PIK3CA PRKCI MCF2L GRB2 SOS1 MATK HRAS FRS2 ARHA FRS3 FAIM SHC3 MAGED1 NTF4 NTF3 SH2B1 NTRK3 ARHG RIT1 RIT2 NTRK2 BDNF PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ZFP36 EGFR KSR1 MYL11 SH2D2A MAPK7 WASL WASF2 MAP2K5 CYFIP2 ARPC1B MAP3K2 NCKAP1 ACTR3 EGR1 PPP5C ACTR2 CREB1 NRAS RPS6KA5 MAPK1 MAPKAP1 ATF1 MLST8 MAP2K4 RICTOR BRAF SRC MAP3K1 ARPC4 KRAS ARPC5 IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA SFN RIN1 PLD2 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 HEL2 BAD STAT3 PIK3R1 PPP2R2A PPP2R1A PRKCZ PPP2CA RAB5A RAC1 RPS6 MAP2K1 MAPK3 PDPK1 MTOR PIK3CA MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 F2RL2 HRAS BCL2L1 MAP2K2 YWHAG EGF ATF2 YWHAZ RAF1 STAT1 SMAD1 USP6NL MEF2C ARF4 BRK1 RPS6KA4 RPS6KA3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY EGFR PRKCA TNKS IGF1R XRCC5 TERF1 TEP1 BCL2 MYC RB1 KRAS PPP2CA TERT BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY ATF2 NFKB1 KAT2B IRF4 RELA JUN IRF3 CREBBP IRF2 IRF1 IRF7 HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAPK7 MAP2K5 MAP3K2 PAK1 CREB1 RPS6KA5 MAPK1 RPS6KA2 MAP3K8 MAP3K6 MAP2K3 CEBPA MAPK13 MAPK6 MAP4K2 MAPK4 MAP2K4 MAPK12 MAP3K1 RPS6KB2 CHUK MAP3K10 MAP3K13 TRADD TRAF2 MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 JUN SP1 MAX MYC MAPK9 MAPK14 IKBKB SHC1 NFKBIA MAPK10 RELA MAP3K7 RAC1 HEL-S-31 MAP2K1 MAPK3 TGFB1 NFKB1 RPS6KB1 TGFBR1 MAPK8 GRB2 HRAS MAP2K2 MAP3K11 ATF2 MAPKAPK3 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K3 RPS6KA4 RPS6KA3 MAP4K1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY SIRT1 CCNB1 RALA RBL2 KAT2B SFN RAN GADD45A MAPK9 HEL2 IKBKB CHUK MAPK10 BCL6 RALB ZFAND5 SGK1 BCL2L11 CSNK1G3 CSNK1D FOXO3A FBXO32 CREBBP CSNK1G2 TNFSF6 CSNK1G1 SKP2 FOXO4 CDK2 FOXO1 MAPK8 YWHAQ CSNK1E HEL-S-1 CSNK1A1 YWHAG CDKN1B CTNNB1 G6PC1 PLK1 YWHAZ EP300 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY LCP2 CRKL CRK JUN MAPK8 MAP3K8 MAP2K4 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY TREX1 NBN RAD51 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG BRCA1 FANCF RAD50 FANCD2 RAD17 CHEK2 RAD1 BRCA2 ATR CHEK1 RAD9A PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGFR WASL PAK1 NRAS PIK3CD MAPK1 PIK3R3 PIK3R2 NCK1 SHC1 STAT3 PIK3R1 SRC KRAS PTPN1 PTPN11 PIP5K1C MAPK3 TLN1 PLCG1 GNAI3 GNAI1 PIK3CA GRB2 SOS1 NCK2 HRAS EGF STAT1 PTPN6 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TNF CASP8 BIRC3 TRADD TRAF2 BAG4 FADD TNFRSF1A RIPK1 TNFRSF1B BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY MAP2K6 PGLYRP1 NFKB1 TLR3 NR1C1 JUN MAPK8 MAP3K7IP1 EIF2AK2 MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA TLR7 MAP3K1 FOS CHUK RELA MAP3K7 TRAF6 IKBKG MYD88 MAP3K14 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 KCNA2 ADCY1 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS RAF1 PLCB1 MAPK1 KCNA1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF2S2 EIF2S1 PDPK1 EIF2S3 MTOR RPS6KB1 EIF4EBP1 IGF1 PIK3CA IGF1R PDK2 PIK3R1 GSK3B PPP2CA EIF2B5 INPPL1 EIF4E PTEN BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY MAP2K1 MAPK3 KLRC2 KLRC3 KLRC4 IL18 PIK3CA KLRD1 PAK1 KLRC1 PTK2B SYK ITGB1 PIK3R1 LAT VAV1 HLA-A RAC1 PTPN6 B2M BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY PAK1 JUN RIPK2 MAP2K4 MAP3K1 FAS MAP3K7 TNFSF6 CASP10 CASP6 SPTAN1 FAF1 MAPK8 PTPN13 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB LMNA FADD DFFB DFFA PARP1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA3 UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP26A1 CYP2C9 CYP24A1 ABCA1 CYP1A2 CYP2E1 NR0B2 ABCG1 NR1H4 NR1H3 NR1C2 NR1i1 NR1B3 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCC3 ABCG5 ABCB1 ABCC2 ABCB4 CYP4A11 CYP4B1 ABCB11 CYP8B1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 RBPJ KDM1A MAML2 MAML1 GATA6 ASCL1 NCOA1 HDAC1 HEY2 NCOR2 SPEN HES6 NOTCH1 GAA RUNX2 RCAN1 ID1 PTF1A BGLAP NEUROG3 STAT3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D RB1 CDKN1B GATA4 TCF3 YY1 EP300 TWIST1 PARP1 HIF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A2 AAG1 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 EIF4G1 EIF3A PDK2 TSC1 PIK3R1 RHEB PPP2CA TSC2 EIF4E PTEN BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY ZAP70 HLA-DRB5 HLA-DRB4 LCK HLA-DRA FYN HLA-DRB3 CD3G HLA-DRB1 CD3E CD3D PTPRC PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 THY1 VEGFA COL1A1 VTN ITGB3 EDIL3 L1CAM SDC1 F11R CD47 FBN1 PECAM1 HMGB1 SPHK1 ITGAV PLAUR KDR LAMA4 LAMC1 TGFBR2 IBSP FGA SDC4 LAMB1 TNC COL1A2 ITGA2B HEL-S-78p THBS1 CYR61 TGFBI PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY RASGRF1 DOCK1 KALRN TIAM1 ARHGEF7 HEL-S-47e ELMO1 DOCK2 DOCK6 VAV2 ARHGAP17 PREX2 RAC1 PREX1 CHN1 RALBP1 SPATA13 TRIO ARHGEF25 SOS1 VAV3 ARHGEF2 ARHGAP1 DEF6 VAV1 BCR RASGRF2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY LY96 TICAM1 TIRAP TLR3 TLR1 SFTPA1 CD14 S100A9 TLR4 S100A8 ARHA VCAN IKBKB CHUK IRAK1 HSPD1 IRAK4 IRAK2 IKBKG MYD88 HMGB1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY TNF BIRC2 BIRC3 NFKBIA MAP3K1 FAS CHUK RELA CRADD TRADD MDM2 TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 PSEN1 NFKB1 CASP6 SPTAN1 MAPK8 PSEN2 BCL2 ACTG1 CDK11A RB1 NUMA1 LMNB2 PRKDC CASP9 CASP8 MAP3K5 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 TRAF1 APAF1 TNFRSF1B BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PRKCA NFKBIA NFKB1 RELA PLCB1 PRKCB BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY NBN RAD51 NFKB1 ATM JUN MAPK8 TP73 GADD45A MRE11A CDKN1A NFKBIA RBBP8 BRCA1 RAD50 RELA MDM2 CHEK2 CHEK1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY HDAC7 GNG2 ADRBK1 UBE2I SUMO1 RAN GNB1 NCOR2 RANBP2 HDAC3 HDAC9 HEL2 HDAC10 HDAC11 HDAC6 HDAC5 CAMK4 BCL6 GATA1 NR3C1 TUBA1B HEL-S-1 RFXANK TUBB2A BCOR ANKRA2 MEF2C GATA2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 MAP2K1 CDK5R1 MAPK3 EGR1 RAF1 NGFR CDK5 MAPK1 NGF DPM2 HRAS PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY ACTN1 PXN CKAP5 TACC3 JUN CREB1 ARHGEF7 HEL-S-28 RICTOR GSK3B IQGAP1 CDC42 RAC1 RUVBL2 RUVBL1 ZYX SNAI1 NCK2 CTNNB1 AURKA CCND1 ILKAP PPP1R14A GIT2 PPP1R14B TNS1 PPP1R14C PARVA ARHG PARVB PARVG NACA CDC37 ELMO2 PARP1 LIMS1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 CLTA AP2A1 AP2M1 PLD2 COPA PIP5K1A GBF1 CLTB ASAP1 ARF1 CYTH2 RAC1 KDELR1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY SPHK1 GNA13 S1PR1 SPHK2 SGPP1 GNAZ SGPL1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 GNA15 GNA11 GNAO1 ABCC1 S1PR3 S1PR2 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 PIK3CA STIL DHH HHIP PTCH2 IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY TGFB1 IGF1 CCL3 EPO KITLG IL3 IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B CCND1 BTG1 CHAF1A BTG2 PRMT1 NGF PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY PIK3R5 ROCK1 EFNA1 EFNA5 BLK SRC EPHA7 YES1 EPHA8 LYN EFNA3 EFNA2 EPHA1 EPHA4 c-fgr EPHA3 FYN VAV2 CRKL CRK PLCG1 CBL LCK CDK5 ARHA VAV3 ARHGEF15 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NEDD8 NR0B2 HEL-S-62p UBE2M NCOA1 NR0B1 NR3A2 UBA3 DDX54 ZNF14 SMARCE1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MAPK3 STAT3 MTOR MAPK1 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY TNF BCL2 CASP9 MAPKAPK3 HSPB2-C11orf52 FAS IL1A CASP3 HEL-S-102 ACTA1 MAPKAPK2 TNFSF6 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA3B GRN SLPI ELA2B CELA1 ELANE CXCL8 CELA2A PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY SIRT1 MYOD1 KAT2B ACSS2 H4C9 FOXO4 FHL2 FOXO1 HOXA10 MEF2D HIST1H1E ACSS1 TUBA1B PPARGC1A TUBB2A CDKN1A BAX EP300 SIRT7 SIRT2 FOXO3A CREBBP SIRT3 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY PRKCA ZAP70 CD8A NRAS CD3G CD3E CD3D PRKCE MAP3K8 BCL10 SHC1 IKBKB KRAS CHUK LAT PRF1 FYN HLA-A TRAF6 RAP1A IKBKG B2M GRAP2 MAP3K14 LCP2 PDPK1 PLCG1 CBL LCK PAG1 GRB2 CD8B1 SOS1 STIM1 HRAS PTPRC TRPV6 ORAI1 CARD11 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY EGFR MAPK3 PDPK1 PIK3CA HEL-S-28 GRB2 MAPK1 SOS1 PDK2 CDKN1B ITGB1 SHC1 PIK3R1 FOXO3A TNFSF6 PTEN PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAP2K6 MAP2K3 MAPK13 EEF2K CCND1 pk MAPK12 SNTA1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY NFATC2 HMOX1 NFATC1 CCNA2 MMP9 JUN IL6 SP1 LIF BGLAP GJA1 FOSL2 CCL2 FOSL1 CDKN2A PLAUR ITGB4 MMP2 CCND1 TXLNG NFATC3 LAMA3 THBD JUNB COL1A2 JUND USF2 EP300 DCN MGP IVL ATF4 CXCL8 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY UROD UROS HMBS GATA1 ALAS1 CPOX HBB HBA2 ERAF ALAS2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI PIK3CA IL7 LCK IL7R BCL2 STAT5B PTK2B PIK3R1 EP300 FYN CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A2 F2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 APP F9 PLG F11 PLAT BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF2 CSTF2 CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY SPHK2 CD8A IL18 IL4 CD3G CD3E CD3D IFNG MAP2K3 IL12B IL12A MAP2K6 CCL4 CCL3 CD8B1 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 SOCS1 RIPK2 MAPK14 STAT3 IL18RAP IL2RG RELB RELA PPP3R1 IL1R1 HLX TBX21 RAB7A GADD45B GZMA IL1B GADD45G HLA-A NFKB2 B2M TNFSF6 IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY NFATC2 PRKCA NFATC1 ZAP70 PPP3CA PPP3CC CALM1 JUN CD3G CD3E CD3D SHC1 PIK3R1 MAP2K4 NFATC4 NFKBIA MAP3K1 RELA LAT FYN RAC1 MAP2K1 MAPK3 NFKB1 PLCG1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CD79A SMAD4 TGFB1 CDKN2A MTOR RPS6KB1 PIK3CA TGFBR1 TGFBR2 TGFBR3 MYC CDKN1B PIK3R1 DKFZp781O1323 PPP2CA MDM2 SMAD1 CTCF PTEN CD79B BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PKN1 GNA13 ROCK1 PRKCA PPP1R12B ARHGAP5 ARHGEF1 PLCB1 PRKCB PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY RALBP1 ITSN2 SPATA13 DOCK9 ITSN1 FGD1 ARHGEF25 DOCK10 DOCK11 PLCG1 ARHGEF9 ARHGEF7 MCF2L HEL-S-47e VAV3 APC FARP2 ARHGAP1 DOCK6 VAV2 ARHGAP17 CDC42 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY ROCK1 MAPK3 CCNA2 EGR1 RABGGTB RABGGTA CDK2 PTP4A1 PTP4A2 PTP4A3 CCNE1 ATF5 MAPK1 TUBA1B ARHA CDKN1A ITGA1 ITGB1 SRC RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY FGA F2 PLG HEL-S-78p CPB2 SERPINB2 PLAT F2R F13A1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY DOCK1 WASL PAK1 MAPK1 NCK1 CAMK2A PIK3R1 SRC YES1 AGAP2 ELMO1 FYN CDC42 RAC1 MAP2K1 TRIO MAPK3 PLCG1 PIK3CA MAP1B ARHA HEL-S-36 MAP2K2 NTN1 UNC5A UNC5B DCC PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAPK1 MAP2K4 MAP3K1 CHUK BTK LAT IKBKG SPHK1 LCP2 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB SHC1 PIK3R1 RELA LYN FYN ITK MAP2K1 PTPN11 FER GAB2 MAPK3 NFKB1 PLCG1 PIK3CA CBL MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS MAP2K2 WIPF1 LAT2 DOK1 HCLS1 RAF1 PLPP1 PLA2G1B VAV1 FCGR2B BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 C1QC HEL-S-62p CFD C1QB C1QA C1S BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET CREBBP DFFA APEX1 HMGB2 BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TNIK MMP9 APC TBXT CAMK4 TCF7L1 ZCCHC12 CHD8 CBY1 RUVBL2 MED12 SALL4 PITX2 MYOG CDKN2A TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 FGF7A MDFIC DVL3 TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 CCND1 CDX4 CDX1 KCNIP4 KLF4 SKP1 BCL9 SP5 TCF4 NEUROG1 CYR61 DKK1 MYF5 INCENP SFN JUN HDAC1 ID2 MYC HEL2 SMARCA4 TERT SNAI2 CCND2 CTBP1 YWHAQ HEL-S-1 MMP2 YWHAG VCAN CTNNB1 TRRAP HDAC2 YWHAZ EP300 CXCL8 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY MAP2K1 PRKCA MAPK3 INSR PLCG1 SLC2A4 PIK3CA GHR GH1 STAT5B SOCS1 GRB2 MAPK1 SOS1 HRAS HNF1A SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PTPN6 PRKCB BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 C1QC HEL-S-62p C1QB C1QA C1S BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY HES1 HNF1A RBPJ GSK3B DVL1 FZD1 HEY2 HES7 WNT1 NOTCH2 NOTCH1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 MAPK1 MYC SYK BAD SHC1 PIK3R1 IL2RG FAS JAK3 TNFSF6 JAK1 MAPK3 CRKL RPS6KB1 PIK3CA CBL IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 HRAS FOS RAF1 IRS1 IKZF3 PTPN6 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY IL5RA PTPN11 CISH PIK3R1 LYN PIK3CA STAT5B IL5 PIM1 GRB2 CSF2RB SDCBP PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY BRSK1 CRTC2 AKT1S1 CAB39 STK11 MAP2 SFN MARK4 STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK3 SIK1 SIK2 MYC HEL2 MLST8 TSC1 GSK3B PRKAG1 SMAD4 SMARCD3 MTOR EZR PSEN2 YWHAQ HEL-S-130P HEL-S-1 PRKAA1 YWHAG PRKAA2 YWHAZ TSC2 PRKAB1 CDC37 RPTOR PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PNKP APLF CSNK2A2 DNTT POLL PRKDC APTX CSNK2B NHEJ1 XRCC5 CSNK2A1 POLM PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS CD3G CD3E CD3D PRKCE MAP3K8 NCK1 KRAS CHUK LAT CDC42 TRAF6 IKBKG RAP1A GRAP2 MAP3K14 LCP2 FLNA PAG1 STIM1 TRPV6 ORAI1 CARD11 CSK PTPN6 PRKCB PRKCA ZAP70 BCL10 IKBKB SHC1 SLA2 STK39 WAS FYB1 FYN ITK PTEN PTPN11 GAB2 PDPK1 PLCG1 LCK CBL GRB2 SOS1 HRAS PTPRC PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAP3K8 MAP2K1 PRKCA MAPK3 BRAF KRAS FOS RAF1 NRAS MAPK1 PRKCB HRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 PRKAG1 LEPR PRKAB1 ACACA CPT1A LEP BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY SMAD4 TGFB1 IL2 TGFBR1 TGFBR2 IL4 IL2RA TGFBR3 CD3G CD3E CD3D IFNG TOB2 TOB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 MAPK3 GNAO1 GNAZ PLCG1 GNAI3 S1PR5 S1PR4 GNAI1 CDC42 MAPK1 ARHA BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A C2 C4A C6 C7 HEL-S-62p C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP5 SST GHRH IGFBP1 IGFBP2 GHRL IGFALS IGFBP6 IGF1 RAPGEF5 GH1 IGFBP4 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY MAP2K1 PTPN11 CEBPB MAPK3 JUN IL6 GRB2 IL6ST SOS1 IL6R CSNK2A1 HRAS SHC1 STAT3 FOS RAF1 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF TGFB1 IL2 IL18 EBI3 IL27 GATA3 IL27RA IL6 IL6ST IFNG TYK2 IL17A STAT2 STAT4 STAT3 IL12RB1 IL12B IL12A STAT1 TBX21 IL1B JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY MAPK3 PRKAR1B CREM PRKAR1A FOS PRKACG JUN CREB1 KCNIP3 OPRK1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY MAP2K1 ROCK1 MYL2 MAPK3 TLN1 PIK3CA ARHGAP5 MAPK1 ARHA HRAS ITGB1 SHC1 PIK3R1 PFN1 RAF1 FYN BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 PLCG1 AP2A1 RPS6KB1 AP2M1 PFKM PFKL GSK3A PRKCE PFKP ARHGEF2 ARF1 BAD GSK3B PRKCZ LYN BTK EEA1 RAB5A VAV2 RAC1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY CSF2RA PXN SPP1 NOS2 VCAM1 VEGFC VEGFD ADAM12 VEGFA KCNJ15 F13A1 ADAM2 ADAM15 ADAM8 ITGB1 PAOX SRC TNC RAC1 CSF2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY CDK5R1 PRKAR1B PPP3CA PRKAR1A DRD1 DRD2 PRKACG PPP2CA PLCB1 CSNK1D CDK5 PPP1R1B BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY TNF IL10 HMOX1 STAT3 HEL-S-10 IL1A IL10RB IL10RA STAT1 IL6 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL17F TNF NOS2 IL18 SOCS3 IL6 CD3E IFNG CXCL9 IL17A STAT3 PIK3R1 NFKBIA IL18RAP IL12B RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 IL24 ALOX12B CXCL1 MPO IL19 IL23A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMB3 LAMA5 LAMB2 LAMA1 ITGB4 LAMB1 LAMA3 LAMC2 LAMC1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY PROS1 F7 COL4A2 F2 COL4A1 COL4A4 COL4A3 SERPINC1 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY NFATC2 NFATC1 AKAP5 CABIN1 PPP3CA CHP1 BATF3 IL4 JUN IL3 IFNG RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 FOSL1 IL2 POU2F1 IL2RA FKBP1A PTGS2 NFATC3 FOS JUNB BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CCL2 LDLR CSF1 ACAT1 IL6 LPL BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK4 CAMK1 CAMK1G CAMKK1 CALM1 CAMKK2 CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG SRA1 PHB2 SET PDIA2 DSCAM POU4F1 LMO4 POU4F2 AP1B1 SAFB LCOR PGR TFF1 NCOA7 CHUK NCOR1 TRIM59 PRDM15 ATP5J HSF2 NDUFV3 NR3A2 XBP1 ABCA3 UBA3 DDX54 EBAG9 CEBPB KLRC3 AXIN2 NR0B1 HEL-S-130P CD82 GREB1 CCND1 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 JUN MED1 NCOR2 HDAC1 PRL MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB CD40LG NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF3 TRAF6 IKBKAP IKBKG MAP3K14 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM7 CCNA2 MCM2 PPP2R1A PPP2CA MDM2 BRCA2 CHEK1 SMARCAL1 CEP164 NBN PPP2R2B ATRIP RAD51 RFC3 CDC6 RFC4 FBXW11 RFC2 CDK2 RPA1 HEL-S-1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 RAD17 RAD1 ATR TOPBP1 CLSPN RAD9A BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCA GRK4 PRKAR1B GNAS PRKAR1A PRKACG PRKCB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY ROCK1 PXN SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 HEL-S-28 MAPK1 SRC ITGB3 F11R ITGAV COL16A1 TLN1 COL14A1 COL12A1 KDR PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 MFGE8 COL5A2 COL9A1 COL9A3 COL9A2 PI4KB HEL114 IRS1 VEGFA COL1A1 PIK3R1 CSF1R VTN CSF1 EDIL3 SDC1 RAC1 PTPN11 MAPK3 COL17A1 RPS6KB1 PIK3CA CBL TGFBR2 PTK2B ARHA VAV3 CDKN1B CASP8 COL3A1 COL1A2 FGF2 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY EFNA1 PIK3CA CBL ARHGAP35 PAK1 TIAM1 GRB2 ARHA VAV3 SHC1 PIK3R1 SRC VAV2 INPPL1 RAC1 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2F GPR37 SUMO1 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS EXOC7 NCK1 SHC1 PIK3R1 PRKCZ EXOC4 SGK1 PARD6A EXOC3 GRB10 EXOC6 FOXO3A EXOC5 EXOC2 PTPN1 EXOC1 RAPGEF1 PTPN11 HEL-S-42 PDPK1 INSR CRK RPS6KB1 PIK3CA CBL PRKCI TRIP10 GRB14 GRB2 SOS1 F2RL2 NCK2 HRAS DOK1 IRS1 SH2B2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY PRKCA GNG2 ADRBK1 PDPK1 CBL GNA14 GNB1 GNA15 PRKCE PLCB3 ARRB2 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 PRKCB CXCR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 AXIN2 DVL1 DVL2 DVL3 FZD5 CSNK1E GSK3A CSNK1A1 WNT3A APC CTNNB1 GSK3B SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY SRP9 PTPN11 CNKSR1 CEBPB CISH GAB2 OSM PRKACG PIK3CA IL3 HDAC1 STAT5B PIM1 GRB2 BCL2L1 ID1 YWHAG SHC1 PIK3R1 YWHAZ CSF2RB IL3RA PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL10 MMP9 EGR1 IL4 CREB1 IL6 TH IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 CDKN2A CDC2 NR3C1 ELF1 TCF7L2 CCND1 EDN1 FOS NFATC3 JUNB JUND CYR61 ATF3 GATA2 MAFG HIF1A NFATC2 CRTC1 NFATC1 DMP1 MT2A CBFB NTS BAG1 PENK FABP4 JUN TRIP6 COPS5 SP1 MYC GJA1 ACTA1 MYB HLA-A PTEN FOSB NPPA FOSL1 TGFB1 IL2 TIMP1 CDKN1B CTNNB1 ATF2 COL1A2 EP300 CXCL8 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY JUN SERPINA1 INS SFTPA2 SP1 C4BPB SFTPD CYP2C18 DSCAM NKX3-1 AP1B1 GCG NR2F2 PISD NFIA NFIB TFF1 VTN SCGB1A1 PRDM15 ATP5J NDUFV3 COL18A1 XBP1 CREBBP KLK3 APOB CEBPB SFTPA1 POU2F1 FOXA1 SHH CDKN1B BRCA1 FOS FOXA3 EP300 FOXA2 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 ACLY PC PDHA1 ME1 CS SLC25A11 HEL-S-32 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAP2K1 PRKCA TNF MAPK3 NFKB1 JUN MAPK1 MYC HRAS NFKBIA FOS RELA RAF1 PLCB1 CUZD1 PRKCB BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY SMAD4 TGFB1 MAPK3 TGFBR1 TGFBR2 ACVRL1 FKBP1A INHBA ACVR2B TLX2 SMAD9 ACVR2A MAPK1 ID1 BMPR2 CSNK2B ARRB2 DKFZp781O1323 ACVR1 SMAD1 ENG BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY EGFR MYL2 PRKAR1B TLN1 PRKAR1A CAPNS1 PRKACG EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCD1 SMARCC1 SMARCA4 SMARCC2 GTF2A1 ARID1A NR3C1 NF1 TBP PS1TP5BP1 SMARCE1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY EGFR MAPK3 PIK3CA GHR GH1 GRB2 ERBB2 MAPK1 SOS1 MUC2 ARHA HRAS TFF2 BAD CTNNB1 ITGB1 SHC1 PIK3R1 CASP9 TFF1 TFF3 APAF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY PRKAR1B CARM1 PRKAR1A PRKACG CREB1 EP300 RXRA CREBBP RARA BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY DPF2 ZBTB7A ITGB1 CCT4 PIK3R1 FOS MTOR PIK3CA CASP3 JUND BIRC5 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB6 HEL-S-276 PSMA4 PSMB2 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY PRKCA ADRA1B PRKCB BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CCR5 FAS CD3G CD3E TNFSF6 CD3D BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY PDE6G RHO SAG PDE6A SLC25A22 GRK1 SLC25A18 RCVRN BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MAP2K1 PRKCA MAPK3 MPL PLCG1 THPO PIK3CA JUN STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 STAT3 PIK3R1 FOS STAT1 RAF1 PRKCB PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY EGFR SDC2 NRAS IL6 NGF IFNG LMO4 KRAS NTRK1 AFDN KDR IFNGR1 IGF1R PAG1 ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 MAP2K1 PTPN11 GAB2 IL2 GNAI3 PIK3CA GNAI1 LCK ARHGAP35 IL2RA IL2RB IL6ST GRB2 IL6R SOS1 HRAS FRS2 ARHA MAP2K2 FRS3 EGF NTF4 NTF3 NTRK3 RAF1 STAT1 NTRK2 BDNF PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF KSR1 MADD SPHK2 CYCS BIRC3 AIFM1 PAWR PRKRA MAPK1 EIF2AK2 PDGFA MYC BAD MAP2K4 NFKBIA MAP3K1 PRKCZ BAX RELA CRADD TRADD TRAF2 SMPD1 TNFRSF1A RIPK1 HEL-S-31 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HEL-S-130P MAP2K2 EGF CASP8 RAF1 BAG4 FADD PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY KSR1 WASL WASF2 ARPC1B ACTR3 ACTR2 PAK1 SLA NRAS DKFZp686P11128 ACTN4 DOCK4 MAPK1 MYOCD HEL-S-47e ACTA2 NHERF2 SIPA1 NCK1 BRAF BLK ARPC4 KRAS YES1 ARPC5 BAIAP2 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 MYC HEL2 SHC1 PIK3R1 LYN PPP2CA GRB10 FYN RAC1 PTPN1 PTPN11 PIK3CA LCK MAPK8 GRB2 SOS1 ARHA MAP2K2 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 IQGAP1 VAV2 AFDN RAP1A SPHK1 RAPGEF1 ITGAV S1PR1 PPP2R2B CRK PAG1 STAT5B CSK JUND PIK3R5 SFN NHERF1 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 STAT3 PPP2R1A MAPK10 RAB5A PTEN MAP2K1 MAPK3 PLCG1 CBL ARHGAP35 YWHAQ HEL-S-1 NCK2 HRAS YWHAG YWHAZ DOK1 ARAP1 STAT1 USP6NL BRK1 RPS6KA3 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY PDE6G RDH12 RHO RGS9BP SAG PDE6A RDH5 GNB1 LRAT GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2S2 EIF2S1 NFKBIA NFKB1 DNAJC3 CHUK RELA EIF2AK2 MAP3K14 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY NME2 PPP3CA SYNJ1 PPP3CC AP2A1 EPN1 AP2M1 CALM1 PICALM BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKAR1B PRKAR1A KDR FLT4 PRKACG BDKRB2 CALM1 VEGFA CHRNA1 KNG1 CHRM1 RYR2 ACTA1 PDE2A PDE3B SLC7A1 PDE3A FLT1 TNNI1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY ACTN1 DOCK1 GRB7 PXN WASL PAK1 ROCK2 ARHGEF7 RRAS MAPK1 NCK1 MAP2K4 BRAF SRC YES1 RAP1A ITGB5 PTPN21 RAPGEF1 ITGAV SH3GL1 ARHGAP26 TLN1 KLF8 CRK BMX CCND1 HEL114 JUN ASAP1 MAPK9 MAPK8IP3 PIK3R1 ELMO1 ACTA1 FYN RAC1 MAP2K1 ARHGEF28 PLCG1 PIK3CA ARHGAP35 MAPK8 MMP14 GRB2 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY TNF CYCS BIRC3 NFKBIA FAS CHUK RELA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 NFKB1 CASP6 MAPK8 BCL2 CASP9 CASP8 MAP3K5 CASP3 BAG4 FADD DFFB DFFA TRAF1 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY EGFR TNKS XRCC5 TERF1 MAPK1 IFNG RBBP4 BLM NBN PINX1 SMG6 PARP2 TINF2 DKC1 POT1 ATM TERF2IP WRN ACD PTGES3 IRF1 MRE11A ZNFX1 HUS1 HNRNPC CCND1 FOS RAD50 RAD1 NCL RAD9A JUN HDAC1 IFNAR2 SP1 MAX WT1 MYC SP3 NR2F2 HEL2 TERF2 SMG5 SIN3B TERT SIN3A SAP30 MAPK3 TGFB1 SAP18 IL2 RBBP7 NFKB1 MTOR RPS6KB1 MXD1 CDKN1B EGF HDAC2 UBE3A BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA CREB1 SP1 MAPK1 RB1 MAP2K2 MAP2K3 MAPK14 PIK3R1 MAP3K1 RELA PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 UBE2I SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY DNAJB1 DNAJB6 NFE2L2 APLP1 RPSA GFAP LAMA1 LAMB1 PRNP LAMC1 BCL2 HEL-S-89n BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF2 TANK TRAF3 RIPK1 IKBKAP TRAF1 IKBKG TNFRSF1B MAP3K14 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY HGS PXN ADRBK1 MMP9 CXCL12 PAK1 CD3G CD3E HEL-S-15 CD3D MAPKAP1 MLST8 RICTOR BLK SRC YES1 RALB c-fgr CDC42 ITGAV CRK FOXO1 PAG1 STAT5B UBQLN1 RGS1 RHOB CSK VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 PIK3CD ITGA4 PIK3R3 ITGA2 PIK3R2 ITGA1 STAT2 BAD STAT3 PIK3R1 ARRB2 PRKCZ LYN ITGA7 ITGA6 FYN RAC1 PTEN PTPN11 PDPK1 GNAZ MTOR GNAI3 PIK3CA GNAI1 LCK ITCH PTK2B PTPRC ARHA ITGB1 GNAO1 PLCB3 CXCR4 STAT1 PLCB1 HLA-DRA VAV1 PLCB2 LIMK1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA IGF1 GHR IGF1R GH1 FOXO3A HEL-S-44 HRAS BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NCK1 HEL-S-276 WASL WASF2 NCKAP1 NTRK1 WASF1 ACTA1 ABI2 PIR WASF3 RAC1 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 PTGS2 PTGS1 NR1I3 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY ADAM10 RBPJ NR1C2 JUN HDAC1 MAPK1 NOTCH1 MYC CSNK2A1 APC NEDD4 GSK3B MAP3K7 CREBBP MAPK3 PSEN1 AXIN1 FBXW11 NLK TLE5 DVL1 CTBP1 FZD1 FRAT1 MAP3K7IP1 CSNK1A1 HNF1A CTNNB1 CCND1 PSENEN FOS LRP6 WIF1 PPP2R5D DKK1 APH1B WNT1 DTX1 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAP2K1 PRKCA MAPK3 NFKB1 CRK PLCG1 CXCL12 PIK3CA MAPK1 PTK2B HRAS PIK3R1 RELA CXCR4 RAF1 PRKCB PIK3C2G BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY FAAH CNR2 BAAT PLD3 PLD2 CNR1 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA MYOD1 BIRC3 NRAS CEBPA KRAS NCOR1 IQGAP1 CREBBP HES1 ADA CEBPB CDKN2A CEBPD ELANE NLK KITLG KIT LEF1 CCND1 SPI1 CCNB1 SLC25A3 PPP3CA LECT2 YEATS4 UBE2I RAG2 CD34 PAX5 SND1 ADORA2B COPA PIM1 TFEC SP1 PRTN3 MAD1L1 MYC HEL-S-11 H2AZ1 ZFHX3 GSTM1 ATP2B1 CBX4 LYZ CSF1R HIPK2 SKI MYF6 ETS2 SIN3A MYB MAP3K7 CDK6 ZFPM1 GATA1 CASP6 GATA3 BCL2 MAP3K7IP1 HRAS CDKN1A CDKN1B PTGS2 COL1A2 TRIM28 EP300 WNT1 MPO BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 BMI1 HDAC1 RBBP4 CBX4 HDAC2 YY1 SUZ12 PHC1 EED COMMD3-BMI1 EZH1 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA13 MAPK3 GNAZ GNAI3 GNAI1 GNA14 PAK1 JUN MAPK8 GNA15 GNA11 MAPK1 ARHA MAPK14 GNAO1 FOS IRS1 RAC1 S1PR2 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL10 IFNA1 IFNB1 IL15 IL13 IL7 IL4 IL3 IL6 IL5 PDGFA IFNG IL11 CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CXCL8 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PRKCA PIK3R1 PLCG1 PIK3CA PLCB1 VAV1 PRKCB BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY MAP2K1 MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA IGF1R GRB2 MAPK1 SOS1 HRAS ADCY1 BAD SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 JUN CD3G CD3E CD3D IFNG MAPK9 PIAS2 STAT3 IL18RAP PPP3R1 TBX21 PRF1 CREBBP TGFB1 IL2 IL2RA MAPK8 IRF1 STAT4 IL18R1 FOS ETV5 CD80 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB SP1 NFYC BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN EPYC KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGAV ITGB7 ITGB6 ITGB4 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGAM ITGA6 ITGAX ITGB5 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY IL10 MYOD1 IFNB1 KAT2B KAT2A RBL1 TFDP1 NR1i1 CREB1 IL5 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CREBBP ITGB5 CEBPB NR3C1 FOXO4 CDK2 FOXO1 NR2A1 FOS ATF3 CBFB NCOA1 JUN HDAC1 SP1 MAX RUNX2 MYC SP3 GSC SKI SIN3B SIN3A FOXO3A SKIL SAP30 SMAD2 SMAD4 SAP18 CITED1 RBBP7 MED15 SNIP1 TGIF1 TGIF2 LAMC1 FOXH1 RUNX3 CTBP1 GATA3 DLX1 FOXG1 CDKN2B DCP1A CDKN1A ATF2 HDAC2 TCF3 COL1A2 NKX2-5 EP300 MEF2C CDK4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 FHL2 NQO1 ATM MAPK8 GADD45A RPA1 NFKBIB DNAJB1 CDKN1A BAX TAF1 MDM2 EP300 ABCB1 HIF1A BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNG2 GNB1 HDAC1 SMO RBBP4 GSK3B ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D CREBBP CSNK1G2 SAP30 CSNK1G1 MAP2K1 SAP18 RBBP7 GNAZ GNAI3 GNAI1 FBXW11 CSNK1E PIAS1 CSNK1A1 SHH IFT172 GLI3 PTCH1 KIF3A RAB23 GNAO1 SUFU HDAC2 SPOP MTSS1 FOXA2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 PPP5C IL4 CREB1 TSG101 IL6 IL5 MAPK1 IFNG SMARCD1 SMARCC1 SMARCC2 GSK3B BAX KRT5 SGK1 TBP MAPK11 CREBBP KRT14 CSF2 NR3C1 PRKACG POU2F1 SELE STAT5B IRF1 FOS NR1I3 POMC SPI1 NFATC1 SFN SUMO2 NCOA1 JUN HDAC1 PRL MAPK9 BGLAP MAPK14 SMARCA4 MAPK10 RELA MDM2 TBX21 MAPK3 IL2 NFKB1 GATA3 MAPK8 CDK5 CDKN1A CDK5R1 HDAC2 CSN2 KMT5B POU1F1 STAT1 EP300 FKBP4 FKBP5 CGA PCK2 CXCL8 AFP PBX1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY SMAD4 SKP2 TGFB1 CDKN2A CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CDKN1A CDKN1B CCND1 GSK3B ATR CDK6 CDK4 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY NCF2 CYBB CYBA NOXA1 WASF2 CYFIP2 ARPC1B NCKAP1 ACTR3 ACTR2 PAK1 JUN PIP5K1A IQGAP3 HEL-S-15 HEL-S-47e MAPK9 MAP2K3 MAPK14 STAT3 MAP2K4 MAP3K1 ARPC4 ARPC5 IQGAP1 WASF1 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 MAP2K6 PIP5K1C CRK ARHGAP5 MAPK8 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 BRK1 NCF1 LIMK1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY EGFR TNF PRKCA HOXA7 JUN SP1 MAPK1 PRKCE CEBPA MAP2K3 MAPK13 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 FAS CHUK RELA ETS2 PPP2CA TRAF2 TNFRSF1A RIPK1 TNFSF6 MAP3K14 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH EGF FOS MAP3K5 PRKCQ RAF1 PRKCB TNFRSF1B BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY LPAR1 PRKACG LPAR2 LPAR3 PRKAG1 ARHA BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 MED1 HDAC1 SRA1 NCOR2 GRIP1 SPEN PHB2 PPARGC1A HDAC3 HDAC6 CCND1 CARM1 GTF2A1 HDAC5 HDAC2 BRCA1 TBP EP300 MEF2C CREBBP PELP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAPK7 MAP2K5 MAP3K2 EGR1 NRAS CREB1 RPS6KA5 MAPK1 MAP2K3 MAPK14 BRAF KRAS TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS CDK5R1 NTF3 FOS RIT1 RAF1 RIT2 RPS6KA1 MEF2C MAPKAPK2 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY TYK2 STAT4 CD2 CXCR3 CCR5 IL12RB1 NOS2 CD3G CD3E IFNG CD3D PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY EGFR PXN MMP9 LPAR1 LPAR2 LPAR3 TIAM1 ADCY9 IL6 PRKCE ADCY3 ADCY1 NHERF2 LPAR4 ADCY8 ADCY6 SRC GSK3B CRK FOS GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN TRIP6 PIK3R1 NFKBIA RELA LYN PRKD1 RAC1 HBEGF NFKB1 GNAZ PLCG1 GNAI3 GNAI1 GNA14 GNA15 GNA11 MMP2 PTK2B HRAS ARHA GNAO1 PLCB3 CASP3 ADRA1B CXCL8 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP2K6 TAOK3 ATM TAOK1 GADD45A TAOK2 MAP3K7IP1 MAP2K3 MAP3K6 MAPK14 MAP3K1 MAP3K10 MAP3K5 TXN TRAF2 GADD45B MAPK11 MAP3K7 GADD45G TRAF6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPV4 ADCY1 KCNQ2 KCNQ3 GNAS KCNQ5 TRPC3 GUCY1A2 TRPC5 GUCY1B1 TRPC4 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 EIF2B5 EIF2AK2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC2 CASP6 BIRC3 BAK1 AIFM1 BCL2 DIABLO CASP9 CASP8 BAX BIK CASP3 DFFB DFFA APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 PRKCE IFNG KRAS STAM2 SOCS2 MAPK11 CISH CDK2 STAT5B FOS PPP2R5D IRS1 IKZF3 PRKCB JUN SOCS3 SOCS1 MYC SYK MAPK9 MAPK14 SHC1 STAT3 PIK3R1 IL2RG FYN JAK3 JAK1 MAP2K1 PTPN11 GAB2 MAPK3 IL2 PIK3CA LCK IL2RA MAPK8 IL2RB BCL2 GRB2 SOS1 PTK2B HRAS ARHA MAP2K2 RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY SH3GL2 ROCK1 ROCK2 PLD2 JUN PIP5K1A HEL-S-15 MAP2K3 LIMK2 MAP2K4 MAPK12 PRKCZ PARD6A ACTA1 SCAI HEL70 CDC42 RDX MRTFA CIT PTEN PKN2 MAP2K6 PIP5K1C MYL2 TLN1 EZR MAPK8 F2RL2 ARHA PKN1 CDKN1B ITGB1 ATF2 SLC9A3 HEL114 FOS STM7 CYR61 LIMK1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 NBN EWSR1 RAD51 FANCL CDK2 ATM FANCA MRE11A FANCC FANCE PRKDC FANCG BRCA1 FANCF PCNA NPM1 RAD50 FANCD2 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY BARD1 FANCC FANCE FANCG BRCA1 FANCF FANCD2 FANCA BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY NFATC2 NFATC1 F2 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 MAPK1 MAPK14 PIK3R1 NFATC4 CAMK4 GSK3B ACTA1 CREBBP NPPA MAP2K1 CTF1 MAPK3 HEL-S-99n PRKAR1B PRKAR1A HAND2 HBEGF MYH2 HAND1 PRKACG RPS6KB1 IGF1 PIK3CA MAPK8 CSNK1A1 HRAS EDN1 GATA4 NFATC3 NKX2-5 RAF1 MEF2C FGF2 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY SDC2 TACI NF1 MAPK1 EPHB2 ITGA2 SRC BAX CSF2 MAPK3 TGFB1 CAV2 EZR TRAPPC4 MAPK8 MMP2 HRAS ARHA ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP CXCL8 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB TOP2A DFFA HMGB2 HMGB1 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PRKCA PLCG1 P2RY2 PTK2B PRKCB BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF MADD PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 MAP3K7 TNFRSF1A CASP2 RIPK1 SPTAN1 MAPK8 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY NUMA1 KPNA2 AURKA RAN KIF15 RANBP1 RCC1 HCTP4 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY SQSTM1 CYCS BIRC2 BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 TRAF6 IKBKG NSMCE3 OMG RTN4R BEX3 MAGEH1 ZNF274 BEX1 RTN4 NDN SORT1 PSENEN RHOB APH1B FURIN RIPK2 MAPK9 ADAM17 HEL2 BAD IKBKB SHC1 PIK3R1 PRKCZ IRAK1 MAPK10 RAC1 MYD88 PSEN1 CASP6 PIK3CA PRKCI APP MAPK8 ARHA DIABLO MAGED1 CASP9 NTF4 NTF3 CASP3 SMPD2 PLG MMP7 BDNF APAF1 MMP3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAP2K6 MAP2K1 TNF MAPK3 VCAM1 IL18 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 DEFA1B NLRP1 IL1B PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY WASF2 CYFIP2 CTNND1 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 PIK3R1 SRC CSNK2B IQGAP1 VAV2 CDC42 RAC1 AFDN RAP1A CTNNA1 JUP ITGAE RAPGEF1 ARF6 ITGB7 PIP5K1C CRK PIK3CA TJP1 ARHA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL5RA HLA-DRB5 CCL11 HLA-DRB4 IL4 HLA-DRA IL6 HLA-DRB3 CCR3 IL5 IL1B HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY EGFR DOCK1 CTRC MMP9 GPLD1 SRC VTN ITGB3 ITGAM RAC1 ITGB5 ITGAV TGFB1 PLAUR CRK ELANE VLDLR ITGB1 FGA HGF FPR1 PLG KLK4 HEL-S-78p FPR2 PDGFD CTSG FPRL2 NCL MMP3 MMP12 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY HGS ROCK1 PXN SH2D2A CAMKK2 MAPK1 ARF1 MAP2K3 NCK1 BRAF SRC ITGB3 IQGAP1 MAPK11 CDC42 FLT1 CTNNA1 MAP2K6 ITGAV KDR FBXW11 FES HEL114 PRKAB1 PTPN6 PRKCB HSP90AB1 PRKCA MYOF VEGFA MAPK14 NEDD4 PIK3R1 VTN PRKAG1 GRB10 FYN MAP2K1 PTPN11 SHB MAPK3 PDPK1 PLCG1 PIK3CA CBL GRB2 PTK2B NCK2 ARHA MAP2K2 PRKAA1 CTNNB1 PRKAA2 RAF1 MAPKAPK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY ARF6 MAPK3 RAB11FIP3 PLAUR KALRN RAB11A PLD2 TIAM1 PIP5K1A MAPK1 ARHA ARF1 RAC1 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY EGFR EGF UBE2D1 ERBB3 NRG1 BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG CREB1 KIT EP300 RPS6KA1 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR MAP2K1 MAPK14 EGF THRA MAP3K1 ZBTB16 NR1A2 NCOR2 RXRA RARA BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 NFKB1 AXIN1 LBP PIK3CA DVL1 FZD1 LEF1 EIF2AK2 APC CTNNB1 CCND1 PIK3R1 GSK3B RELA PPP2CA GJA1 WNT1 MYD88 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 LDB1 DVL1 FZD1 MED1 HDAC1 LEF1 APC CTNNB1 TRRAP GSK3B EP300 WNT1 CREBBP KAT5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A CD58 CD34 KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CSF3 CXCL8 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY NCF2 NFATC2 NFATC1 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 NFKBIA MAP3K1 RELA RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 HRAS MAP2K2 NFATC3 FPR1 RAF1 PLCB1 NCF1 PIK3C2G BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY PSEN1 RBPJ AXIN1 DVL1 FZD1 BTRC NOTCH1 ADAM17 APC HNF1A CTNNB1 GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 CCL11 HLA-DRB4 IL3 HLA-DRA HLA-DRB3 CCR3 IL5 HLA-DRB1 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY KDR FLT4 VEGFC VEGFD NRP1 VEGFA NRP2 VEGFB FLT1 BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY TNF NR3C1 HSD11B1 RETN RXRA LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY PIN1 CCNB1 MAPK3 PRKAR1B CDC2 PRKAR1A PRKACG CAP1 PAQR7 PAQR5 MAPK1 HRAS ADCY1 PGR MYT1 ACTA1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PDGFRA RALBP1 NCF2 TRIO MYL2 RPS6KB1 PIK3CA PAK1 CDK5 CDK5R1 PIK3R1 MAP3K1 PPP1R12B WASF1 VAV1 RAC1 LIMK1 CHN1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A1 MMP9 COL4A4 COL4A3 COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 MAPK3 TGFB1 COL17A1 COL16A1 LAMA5 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 MET COL3A1 HGF COL1A2 CASK SDCBP MMP7 CCL5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP10 CASP8 CASP3 ARHGDIB ARHGAP5 JUN PRF1 PARP1 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP JUN SOCS3 IL6 MYC TNFSF11 LMO4 CRP HEL-S-125m MAPK14 A2M STAT3 PIK3R1 MAP2K4 PTPRE MCL1 MAPK11 RAC1 JAK1 MAP2K6 PTPN11 CEBPB GAB2 CEBPD PIK3CA FOXO1 GRB2 IL6ST TIMP1 IL6R PIAS1 SOS1 IRF1 BCL2L1 TYK2 FOS JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY CDK5R1 VLDLR LRP8 DAB1 FYN RELN CDK5 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 CREB1 IL6 TH MAPK1 IFNG DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE CCND1 FOS JUNB JUND ATF3 PRKCA ARG1 CBFB NOS2 NF1 JUN INS SOCS3 GADD45A PPARGC1A MAPK9 MAPK14 HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 DUSP5 MAPK8 BCL2 MMP2 SERPINB5 BCL2L1 RB1 ATF2 BRCA1 EP300 DDIT3 CXCL8 CDK4 IL23A BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PKN1 CDC2 MAP2 PRKACG PPP2CA PRKAG1 NUP85 AKAP9 PRKCE PCNT ARHA PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY NFATC2 PRKCA NFATC1 AKAP5 CABIN1 PPP3CA CHP1 SFN RAN MEF2D NUP214 PIM1 PRKCE CSNK2A1 RCAN1 MAPK9 MAP3K8 KPNA2 HEL2 BAD MAPK14 CAMK4 MAP3K1 GSK3B PRKCZ PPP3R1 CREBBP MAPK3 MAPK8 FKBP1A BCL2 YWHAQ HEL-S-1 CSNK1A1 BCL2L1 YWHAG PRKCH NFATC3 YWHAZ CASP3 PRKCQ EP300 PRKCB BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG MUSK BAD RAPSN PIK3R1 PIK3CA TERT FOXO3A TNFSF6 PTK2B CHRNB1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY ADAM10 NUMB RBPJ KDM1A MAML2 MAML1 RAB11A ADAM12 IL4 HDAC1 NCOR2 SPEN NOTCH1 MYC RBBP8 NCOR1 FBXW7 SKP2 NOTCH3 MYCBP PSEN1 DLL3 DLL4 DNER CBL JAG2 MIB1 CTBP1 GATA3 MFAP5 MFAP2 CNTN1 ITCH LNX1 ENO1 CDKN1A CCND1 PSENEN YY1 SKP1 EP300 APH1B NOTCH2 DTX1 FURIN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY BMP4 BMP2 BMPR1A NUP214 MAPK1 SMAD9 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CHRDL1 ZFYVE16 SOSTDC1 CER1 BAMBI CTDSP1 AHSG CTDSP2 FST CTDSPL HFE2 BMPR2 RGMB BMP6 RGMA DKFZp781O1323 GREM1 SMAD1 NOG BMP7 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY IFNA17 TNF TNFRSF18 IFNA10 IFNA1 IFNA21 EGR4 CD8A IF1AA9 EGR1 NRAS CD3G CD3E MAPK1 CD3D PRKCE IFNG BRAF KRAS TNFRSF9 CD8B1 STAT4 FOS NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA JUN IFNAR2 IFNAR1 MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 IL2 IL2RA MAPK8 IL2RB HRAS MAP2K2 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 IFNA16 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROS1 F7 FGA F2 F10 F3 SERPINC1 F5 TFPI HEL-S-78p PROC F2R PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY EGFR YBX1 NOX4 INS SOCS3 PRL LEP PRLR SHC1 STAT3 PIK3R1 BLK CSF1R SRC CSF1 ITGB3 YES1 LYN LAT CDH2 LEPR c-fgr FYN PTPN1 FER INSR CRK PIK3CA LCK STAT5B GRB2 TRPV6 ARHA TYK2 EGF CSK CSN2 DOK1 ITGA2B TXN SPRY2 IRS1 FCGR2A BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL2 CD8A IL7 EPO IL4 IL3 IL6 IL5 IL9 IL11 CSF1 CSF3 CXCL8 CSF2 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY NFATC2 TNF NFATC1 EGR4 BATF3 IRF4 EGR1 IL4 DGKA JUN IL3 SLC3A2 IKZF1 IL5 PTPRK GBP3 IFNG PPARG EGR2 RNF128 CD40LG TBX21 FOXP3 PTPN1 TNFSF6 CSF2 CTLA4 FOSL1 IL2 POU2F1 IL2RA GATA3 ITCH PTGS2 NFATC3 FOS CASP3 JUNB PRKCQ CXCL8 CDK4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY HDAC9 MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EGFR VEGFA INS PIK3CD EIF2AK2 PIK3R3 PIK3R2 LMAN1 KPNA2 ITGA1 SHC1 STAT3 PIK3R1 CSF1R SRC CSF1 CREBBP JAK3 PTPN1 JAK1 INSR KDR PIK3CA STAT5B RAB4A GRB2 PIAS1 SOS1 ITGB1 EGF MET HGF STAT1 ATR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK3 EP300 CREBBP MAPK1 PELP1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CD40 CR2 CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 FCGR2B HLA-DRB1 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY DLG4 PCLO DLG2 GRIN1 GUK1 NRXN3 NCAM1 SPTAN1 CASK ADD1 ACTA1 SPTBN1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAP2K1 ROCK1 MAPK3 MAPK8 MAPK1 ARHA HRAS MAP2K2 HNF1A MAP4K2 MAP3K1 ACTA1 MAL RAF1 CDC42 RAC1 LIMK1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY TYK2 STAT3 STAT1 SOCS3 STAT5B JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 CSNK1E PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY ITGB1 IL1A VCAM1 CD34 MADCAM1 SELL PECAM1 ITGA4 ICAM2 CXCL8 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 SHC1 PIK3R1 LYN BTK SH2B3 VAV2 PLCG2 TEC RAP1A RAPGEF1 PTPN11 CRKL EPOR NFKB1 PLCG1 CBL EPO MAPK8 BCL2 STAT5B GRB2 SOS1 HRAS TRPC6 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY PTCH1 GLI3 PRKAR1B PRKAR1A SUFU GSK3B PRKACG DYRK1A SMO DYRK1B SHH PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B RFWD2 CCNG1 GSK3B CSNK1G3 CSNK1D KAT5 CSNK1G2 CREBBP CHEK1 CSNK1G1 RPL5 DYRK2 PIN1 SETD8 SKP2 SETD7 CDKN2A TP53AIP1 RASSF1 PPP1R13L KAT8 RPL23 FBXO11 CDK2 PPM1D ATM PTPA SMYD2 CSNK1E E4F1 MDM4 CSNK1A1 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 HIPK2 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY MAP2K1 PTPN11 MAPK3 INSR SLC2A4 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC2 CLTC BIRC3 PIK3CD PIK3R3 PIK3R2 MAPK9 SYK MAPK14 IKBKB PIK3R1 SRC MAP3K1 FAS CHUK MAPK10 BTK SMPD1 MAPK11 RIPK1 IKBKG TNFSF6 MAP2K6 CASP10 PDPK1 EZR PIK3CA MAPK8 FAIM2 CASP8 CASP3 FADD RFC1 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY RBX1 UBE2I UBA2 SAE1 EDEM1 FBXO2 SEC61A1 GANAB MAN2A2 CANX MAN1A2 GCS1 UGGT1 SKP1 MAN1A1 MAN2C1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EEF2 EIF6 EIF4E EIF1AX PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK MAP3K1 CHUK BTK POU2F2 VAV2 PLCG2 TRAF6 IKBKG PAG1 CARD11 FOS CSK CD19 SH3BP5 CD72 IBTK CD22 PTPN6 NFATC1 PPP3CA PPP3CC JUN CSNK2A1 SYK BCL10 MAPK14 IKBKB SHC1 PIK3R1 NFKBIA RELA LYN MAP3K7 CAMK2G RAC1 PTEN CD79B CD79A MAP2K1 MAPK3 PDPK1 NFKB1 PIK3CA MAPK8 GRB2 SOS1 HRAS PTPRC NFKBIB DOK1 BCL2A1 RAF1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNA13 GNG2 MMP9 GNB1 ROCK2 NRAS GNAL SHC1 PIK3R1 SRC KRAS HEL70 NR3A2 MAPK11 PELP1 HBEGF GNAZ GNAI3 GNAI1 PIK3CA IGF1R GNA14 GNA15 GNA11 GRB2 SOS1 MMP2 HRAS ARHA GNAO1 PLCB3 PLCB1 PLCB2 STRN BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 PROS1 SERPING1 COL4A2 KLKB1 F2 COL4A1 COL4A4 COL4A3 SERPINC1 F5 COL4A6 COL4A5 F9 F11 F2R FGA KNG1 F10 HEL-S-78p PROC PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 ITGAV ITGB7 ITGB6 PLAUR VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 MADCAM1 FBN1 CYR61 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF USH1C LIN7A NFKB1 IFNGR1 TAX1BP3 IFNGR2 IFNG WT1 RB1 IKBKB NFKBIA RELA TNFRSF1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY ACTN1 CTNNB1 ACTN2 HEL114 LRRTM2 CSK CTNNA3 CTNNA2 PECAM1 CTNNA1 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 SKP1 TFDP1 FBXW7 CDK2 CDC34 CCNE1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA3 GPX1 GABRA2 GABRA6 GABRA5 PRKCE GABRA4 HEL-S-44 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY SPHK1 S1PR1 ITGAV MAPK3 GNAZ KDR PLCG1 GNAI3 GNAI1 VEGFA MAPK1 ARHA GNAO1 PTGS2 ITGB3 ABCC1 PLCB2 RAC1 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RANBP1 RCC1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 SKP2 SKP1 TFDP1 CDK2 CDC34 CCNE1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC CALM1 JUN SYK MAPK14 SHC1 NFATC4 MAP3K1 LYN BTK RAC1 CD79B CD79A MAP2K1 MAPK3 PLCG1 MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 CREB1 GRB2 SOS1 PTK2B HRAS PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY NOS2 EIF4EBP1 GDI1 JUN CREB1 USF1 KRT19 RPS6KA5 PPARGC1A CSNK2A1 CSNK2A2 ATF1 MAPK14 CSNK2B RAB5A MAPK11 EIF4E CEBPB ATF2 PTGS2 MAPKAPK3 HEL-S-102 DDIT3 MEF2C MAPKAPK2 MAPKAPK5 RPS6KA4 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY EGFR PAK1 JUN CHRNA1 SP1 DAG1 MAPK1 DMD AGRN PAK4 ACTA1 CDC42 NRG1 RAC1 NRG2 MUSK NRG3 MAPK3 RAPSN LAMA4 DVL1 MAPK8 ITGB1 CHRM1 GIT2 LAMA3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF C6 C7 VCAM1 IL6 ITGA4 ITGB1 KNG1 HEL-S-62p IL1A SELP SELPLG CXCL8 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY TUB CHRM1 PLCB1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PRKCA PXN GDNF JUN CREB1 MAPK1 PDLIM7 NCK1 DOK4 SHC1 DOK5 PIK3R1 DOK6 SRC SHANK3 GRB10 RAC1 RAP1A PTPN11 MAPK3 CRK PIK3CA MAPK8 GRB2 SOS1 HRAS FRS2 ARHA DOK1 RET IRS1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY NFATC2 MAP2K1 PRKCA NFATC1 MAPK3 PRKAR1B PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 JUN CREB1 HRAS ADCY1 NFATC4 NFATC3 FOS RAF1 PRKCB RPS6KA3 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY DOCK1 PXN SPP1 VCAM1 ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 RAC1 ARF6 JAM2 PRKAR1B TLN1 PRKAR1A CRK MYH2 CD14 PTK2B ITGB1 YWHAZ THBS1 MDK BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY PRKCA EIF2S1 TLN1 CASP6 ATM BCL2 BAD CASP9 BAX CASP3 STAT1 PARP1 APAF1 PRKCB BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAP2K1 PRKCA MAPK3 F2 MAPK1 F2RL3 F2R HRAS SYK ITGB1 PTGS1 RAF1 PLCB1 PRKCB BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY PRKCA CCNB1 CDC2 CSK CDC25B VPS16 GRB2 PRKCB PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 EFNA1 EGLN1 EGLN3 VEGFA SP1 APEX1 SLC11A2 CREBBP POU5F1 FLT1 ADORA2A EIF3E FXN EGLN2 KDR VHL ELOC HIF1AN EPO CITED2 MMP14 HEL-S-68p ABCG2 EP300 BHLHB2 TWIST1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 TIAM1 EPHB2 EPHB1 EPHB4 PIK3R1 MAP2K4 BLK SRC ITGB3 YES1 LYN c-fgr FYN MAP3K7 RAC1 PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC2 BIRC3 IL4 JUN MYC MAPK9 CD40 MAPK14 CD40LG MAP2K4 NFKBIA MAP3K1 MAPK10 RELA TRAF2 TRAF3 MAPK11 TRAF6 JAK3 MAP3K14 C4BPA FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY AKT1S1 PXN CYCS EIF4EBP1 NRAS CCNE1 MAPK1 MAPKAP1 PML RB1CC1 MLST8 RICTOR BRAF KRAS SGK1 FBXW11 CDK2 EEF2K EEF2 TSC2 RPS6KA1 IRS1 DDIT4 PRKCA SFN BNIP3 EIF4A1 PLD2 PPARGC1A HEL2 IKBKB TSC1 RHEB RAC1 EIF4E MAP2K1 MAPK3 PRR5 PDPK1 RRAGA RRAGB MTOR RRAGD RPS6KB1 ULK2 ULK1 RRN3 POLDIP3 EIF4B YWHAQ HEL-S-1 HRAS ARHA MAP2K2 YWHAG YWHAZ YY1 RAF1 RPTOR DEPTOR BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF PRKCA NOS2 NR0B2 NR1H3 NCOA1 JUN SRA1 MED1 NCOR2 RXRA SP1 LPL MAPK1 PDGFA MYC PPARGC1A PIK3R1 NFKBIA NCOR1 RELA ME1 CREBBP MAPK3 PRKAR1B PRKAR1A NR1C1 PRKACG PIK3CA CITED2 HSD17B4 STAT5B MRPL11 DUT APOA2 RB1 FABP1 ACOX1 EHHADH PTGS2 EP300 PRKCB BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A CFP C6 C7 HEL-S-62p C9 CFD PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 CCNE2 GDF15 PML FAS BAX NTRK1 BCL2L11 MAPK11 BRCA2 CASP2 KAT5 FASN CHEK1 PIN1 ADA RAD51 TP53AIP1 CDC2 CLCA2 FLOT2 CDK2 TP73 AEN TUBA1A TP63 PLK1 S100A2 CCNB1 SFN PLK3 SERPINA1 HEY2 SP1 WWOX WT1 MYC YAP1 MAPK14 BIN1 TP53I3 RELA MDM2 FOXO3A CDK6 JAK1 BBC3 GATA1 JAG2 ITCH RB1 CDKN1A RNF43 UBE4B HAGH PFDN5 FBXO45 PLPP1 GRAMD4 EP300 HSF1 DEDD D4S234E DCP1B AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY PI4K2A AXIN1 DVL1 DVL2 DVL3 FZD5 GSK3A WNT3A APC CTNNB1 GSK3B STM7 LRP6 PPP2R5A KLHL12 CSNK1G1 NKD2 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPRO PIK3C2B SPRED1 STAP1 SOCS1 BAD SHC1 STAT3 PIK3R1 GSK3B LYN SNAI2 GRB10 SH2B3 FOXO3A TEC CREBBP PTEN GRAP2 MAP2K1 PTPN11 FER MAPK3 CRKL EPOR PDPK1 RPS6KB1 PIK3CA CBL EPO KITLG MAPK8 KIT BCL2 GRB2 SOS1 MATK HRAS MAP2K2 DOK1 STAT1 RAF1 VAV1 SH2B2 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CCL2 TNF CSF1 MST1R IL1B PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EGFR SH3GL2 HGS ITSN1 UBE2D1 UBE2D2 ZFYVE28 CHMP3 AMPH STAMBP NRAS TSG101 ARHGEF7 PIK3CD LRIG1 PIK3R3 PIK3R2 UBE2D3 SHC1 PIK3R1 SYNJ1 SRC KRAS EPN1 RAB5A CDC42 PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 SPRY2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK3 MAPK7 SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 CREB1 RPS6KA1 GRB2 MAPK1 HRAS BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF7B SPP1 MMP9 CTNND1 SDC2 FGFR1 FGF6B JUN FGF8 FGF9 FGF8A MAPK1 FGF23 RUNX2 FGF18 PAK4 FGFR4 FGFR3 BGLAP FGFR2 SHC1 CAMK2A PIK3R1 SRC NCAM1 CDH2 PTPN11 MAPK3 PDPK1 PLAUR PLCG1 PIK3CA CBL FGF7A STAT5B GRB2 SOS1 PTK2B FRS2 MET FOS HGF STAT1 SSH1 RPS6KA1 SPRY2 FGF2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY GAS2 BIRC2 BIRC3 TNFRSF25 NFKBIA CHUK RELA TRADD TRAF2 RIPK1 MAP3K14 CASP10 NFKB1 CASP6 SPTAN1 TNFSF10 BCL2 CASP9 CASP8 CASP3 LMNA FADD DFFB DFFA APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY RBL1 NFYA CREB1 NFYB NFYC CEBPA GFI1 CLU FTH1 SFRP1 TMEFF2 CSDE1 TBP TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 DKK1 SPI1 HDAC1 GADD45A SP1 MAX ID2 MYC HDAC3 DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 BCL2 ERBB2 CDKN2B CDKN1A CDKN1B ITGB1 BRCA1 COL1A2 EP300 DDIT3 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CDKN2A CCNB1 CDC2 RBL1 TFDP1 CDK2 CCNE1 CDKN2B CDK7 RB1 CCNH CDKN1A CDKN1B CDKN2D CCND1 CCND3 CCND2 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 PDGFRA EGFR SH3GLB2 PRKCA EGF MET CSF1R CBL GRB2 PRKCB BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY MAP2K6 SMAD4 TNF NFKB1 NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA CHUK RELA EP300 MAPK11 MAP3K7 IL1B CREBBP CXCL8 MYD88 MAP3K14 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 ITGAV NPNT JAM2 NID1 PLAUR CSPG4 COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA ITGA4 ITGA2 ITGA1 COL1A1 VTN IGSF8 CD81 ITGA7 THBS2 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 ITGB1 LAMB2 LAMA1 LAMB1 LAMA3 COL3A1 TNC COL1A2 THBS1 MDK BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY NFATC2 MAP2K3 NFATC1 MAPK14 PRKAR1B PRKAR1A PRKACG IL13 IL4 GATA3 IL5 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY RALBP1 MAP2K1 MAPK3 RALA NFKB1 FOXO4 PIK3CA ARHA HRAS BAD PIK3R1 CASP9 CHUK RELA RAF1 CDC42 RAC1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY MAP2K1 PTPN11 MAPK3 IGF1 PIK3CA IGF1R JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAP2K1 PRKCA MAPK3 CRKL PLCG1 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAP2K3 MAPK14 SHC1 MAP2K4 MAP3K1 RAF1 RAC1 PRKCB PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY KDM1A UBE2I PAWR RANBP9 XRCC5 MED1 NKX3-1 CARM1 UBA3 PELP1 CDK6 TMPRSS2 KLK3 CDKN2A KDM3A TMF1 TGFB1I1 TGIF1 FHL2 ZMIZ1 PATZ1 APPL1 SVIL KDM4C NCOA6 PIAS1 PTK2B PA2G4 LATS2 VAV3 CTDSP1 MAK CTDSP2 ZNF318 SNURF CTNNB1 CCND1 CMTM2 PRKDC BRCA1 CASP8 CCND3 TCF4 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY EGFR MAP2K1 PRKCA MAPK3 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 SHC1 ATF2 MAP2K4 MAP3K1 AGTR1 RAF1 RAC1 PRKCB BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY PRKCA CCL2 PLCG1 CXCL12 CCL4 CALM1 JUN MAPK8 PTK2B MAPK14 CCR5 FOS CXCR4 PRKCB BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPOR NFKBIA NFKB1 GRIN1 RELA EPO HIF1A CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway MYO1E MYO1B MYO1C SLC6A8 ACTC1 MYO1A MYO15A MYO5B MYO5C CHRFAM7A MYO1F MYO1G SLC44A3 ACTB ACTG2 ACTG1 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB2 CHRNB1 CHRNB4 CHRNB3 MYH15 MYO7B MYO7A ACTA2 MYH1 ACTA1 SLC5A7 MYH2 MYH3 ACTBL2 MYO3B CTAGE4 MYO3A CTAGE9 MYH8 MYH9 MYH4 MYH6 CTAGE15 MYH7 CHRNA1 CHRNA3 CHRNA2 PLEKHH3 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 MYH11 MYH10 MYH7B MYO10 MYO5A MYO9A MYO19 MYO16 MYO1D NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells CHUK PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors SUMO2 RARA PGR PPARG PPARA PIAS4 HDAC4 PIAS3 THRB UBE2I VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) RAD1 ATM RAD9B ATR RAD9A UBA52 UBB UBC RPS27A SEM1 MUS81 MRE11 BRCA1 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE POLH GEN1 RFC5 RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RTEL1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 XRCC2 XRCC3 RPA1 RPA2 PALB2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells HGS CTNNB1 EPS15 CBLL1 MET STAM2 SH3GL2 SH3GL1 UBA52 UBB SH3GL3 SH3KBP1 SRC UBC CTNND1 STAM RPS27A CBL CDH1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK RALA SHC2 RALB SHC3 SHC1 YWHAB CRKL NRAS RAP1A MAPK1 HRAS RALGDS MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling PPARA ATF2 CRTC2 SLC46A1 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 LY96 HBB BACH1 NPAS2 HELZ2 RAI1 XPO1 PGRMC2 TGS1 NRIP1 HMOX1 EP300 TBL1X APOB CLEC1B MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 APOA1 HBA2 NR1D1 SIRT1 NCOR1 TBL1XR1 RORA CARM1 MAFK TLR4 BMAL1 CLOCK NFE2L2 RXRA DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) CHUK NFATC3 PRKCB NFATC2 FBXW11 NFATC1 PSMA5 FKBP1A PSMA6 CALM1 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB NRAS HRAS PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PPP3CA PSMD3 PPP3CB PSMD1 IKBKG PPIA BTRC RASGRP1 MAP3K7 RASGRP3 SKP1 PPP3R1 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models CAST YWHAE APP JUN FASLG SOD2 CDC25C FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC44A2 SLC44A5 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer NOTCH1 RBX1 CUL1 SKP1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) GLP1R UCN VIPR1 VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP ADGRE2 SHH GNGT2 ADGRE5 UCN3 UCN2 ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP ADCYAP1 SMO CRH IAPP ADCYAP1R1 RAMP2 CALCA RAMP3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 PTHLH CRHR1 GHRHR WNT6 GNG10 GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 WNT2 CD55 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 FZD4 WNT3A PTCH1 FZD7 GCGR WNT7B FZD6 PTCH2 FZD9 SCTR FZD8 WNT7A GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH GNB1 GNAS GNB4 GNB3 GNB5 VIP RAMP1 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs SPRED3 SPRED2 SPRED1 SYNGAP1 PSMA5 PSMA6 RASA3 PSMA3 RASA4 PSMA4 RASA1 PSMA1 RASA2 PSMA2 CUL3 UBA52 RASAL1 RASAL2 PSMD12 RASAL3 PSMD11 DAB2IP PSMD14 NF1 PSMD13 KBTBD7 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NRAS HRAS PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis GAD2 GAD1 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG5 IDS CSPG4 GUSB ARSB IDUA HEXB NCAN HEXA BGN DCN GLB1L3 GLB1L2 BCAN VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants FLT3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion PLK1 CCNB1 CDK1 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 XPO1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 FIRRM DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells PRL DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) MSH6 MSH2 MSH3 PMS2 MLH1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors OXTR AVPR1B AVPR2 OXT AVP AVPR1A SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS PTDSS2 PTDSS1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins CASP3 CTNNB1 DSG1 PKP1 DSG2 DSG3 TJP2 DSP TJP1 OCLN CDH1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin FDX1 FDXR FDX2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family HLA-DRB3 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 ASH2L CD3G MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 TEAD3 H3-3B HLA-DPA1 TEAD4 H3C8 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 YAP1 DERL3 DERL1 DERL2 TRBV12-3 CTNNB1 H3C15 PAK1 TRBV7-9 OS9 SPOP RICTOR PAK3 PAK2 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 TRAV8-4 HLA-DPB1 FOSB CD86 TUSC3 CD80 TRAC H2AB1 GRAP2 NEK2 MAP3K8 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 BTLA THEM4 TNFRSF14 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 MAP3K14 PRR5 GSK3B PIK3CD DPY30 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EP300 EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA CREBBP DAD1 LCK IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN CSK NFE2L2 RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 TNRC6A TNRC6B JUN RBX1 CUL3 CCND1 CDK4 PPP2R1B PPP2R1A PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 TRBC1 AKT1 ICOSLG PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B TRIB3 ATF3 RPN2 EPAS1 MAPKAP1 RPN1 PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 PIK3R5 TRAV29DV5 HLA-DQA2 LYN WWTR1 HLA-DRB5 YES1 H4C9 HLA-DRB4 JUND ERLIN1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 CD28 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane GJA1 GJB2 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding STAT3 CCNE2 CCNE1 HDAC3 GNGT1 GBA1 GNGT2 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B TUBA4A FBXW2 XRN2 GAPDHS FKBP9 TP53 ARL2 TBCD TBCC TBCB TBCA CCT6A GNAQ GNG10 TBCE PDCL GNG3 FBXL3 FBXL5 GNG2 TUBA8 WRAP53 GNG5 TUBA1C GNG4 TUBA1B GNG7 TUBA1A GNG8 KIF13A CCT3 CCT2 CSNK2A1 VBP1 CSNK2A2 SPHK1 TUBB2B CSNK2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 GNA15 TUBA3D TUBA3C GNA11 CCT8 GNG12 CCT7 GNG11 CCT5 GNG13 CCT4 NOP56 GNB2 ARFGEF2 TUBB4B GNB1 TUBB4A RGS11 GNB4 GNB3 GNB5 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins POM121C NUP42 NUP62 NUP43 TPR BANF1 NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 SLC25A5 SLC25A4 SLC25A6 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MAD2L1 BUB1B ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 CCNB1 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions GJA10 GJC1 PANX1 GJD2 PANX2 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection POM121C NUP42 NUP62 TPR NUP88 RAE1 KPNA1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 RPL35 KPNA4 RPL38 KPNA5 NUP107 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 NUP160 KPNB1 RPS4Y2 RPS4Y1 RPL39L NUP85 CPSF4 RPL41 TGFB1 MLKL EIF2AK2 ISG15 RPL3L XPO1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 SEC13 RPS24 RPS23 NUP133 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 NUP43 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RANBP2 RPL23A UBA52 RPL22L1 FAU RAN RPL26L1 HSPA1A RPS27A NUP37 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 NUP205 POM121 NUP188 AAAS DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling BLK ELF1 ELF2 CBFB PAX5 RUNX1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 NUP37 NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 THOC6 SRRM1 DDX39A NUP107 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 NUP160 CHTOP ALYREF UPF3B MAGOHB NXF2B NUP85 RNPS1 SEC13 NUP133 NUP205 POM121 NUP188 AAAS FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate ZNF521 WNT3A SOX2 ZEB2 FGF8 SOX1 GBX2 OTX2 TBX6 POU3F1 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX PRKRA DICER1 TARBP2 TSN AGO3 AGO4 AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 MCOLN3 TRPC5 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 TRPC4AP TRPV6 TRPV4 TRPV5 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN LAMA5 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 AP1G1 PACS1 AP1S2 AP1B1 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD9 PSMB2 PSMD4 PSMB3 PSMD5 PAAF1 PSMB1 PSME3 PSME4 ADRM1 PSME1 PSME2 SEM1 PSMD10 PSMB11 PSMC5 POMP PSMC6 PSMB10 PSMC3 PSMA8 PSMC4 PSMF1 PSMC1 PSMB8 PSMC2 PSMB9 PSMG3 PSMG4 PSMG1 PSMG2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation UBE2D1 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 PDPK1 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 PSMD8 V1-3 IKBKB IGKV3D-20 PSMD6 V5-6 PSMD7 TRAF6 PSMD2 IGHE PSMD3 IGLV3-19 PSMD1 IGKV2-30 IKBKG IGHV2-70 BTRC RASGRP1 IGHV2-5 MAP3K7 IGLV3-1 SKP1 IGHV3-48 CHUK IGLV3-25 IGLV3-27 FBXW11 IGKC PSMA5 IGLV3-21 PSMA6 IGKV1-39 PSMA3 IGKV1-33 PSMA4 V4-6 PSMA1 IGHV3-53 PSMA2 V4-2 UBA52 IGLC7 CARD11 V4-1 PSMD12 IGKV5-2 PSMD11 IGKV1-5 PSMD14 IGLC6 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LYN TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity YWHAE CSF1 MC4R HINT1 EDNRB QARS1 ZIC1 RPS6KA1 TNFSF11 SOX9 YWHAH FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB CDH1 PAX3 MITF POU3F2 CTNNB1 YWHAZ SOX10 DARS1 MC3R LARS1 KIT TFEC EEF1E1 HDAC1 KARS1 ALX3 YWHAB IARS1 MARK3 TBX3 POMC MAPK1 UBE2I AIMP1 AIMP2 MC1R MAPK3 EPRS1 ID1 MC5R SNAI2 SUMO1 GSK3B SOX2 AKT3 XPO1 YWHAG EP300 WNT3A CREBBP SIRT1 LEF1 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 CAV1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME VAV3 ABCC4 GSTM1 TPMT ABCC5 NME2 GMPS NME1 RAC1 VAV2 IMPDH1 GUK1 GSTA2 IMPDH2 GSTA1 HPRT1 SLC28A2 SLC29A1 NUDT15 VAV1 XDH SLC29A2 SLC28A3 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CUL3 CCT6A HSP90AB1 ROCK1 ROCK2 CCT2 GPS1 TWF1 MSI2 RHOBTB1 ACTG1 RHOBTB2 TRA2B MYO6 STK38 RBBP6 RNF20 SPEN CPSF7 TMOD3 ACTN1 TXNL1 COPS4 COPS2 HSP90AA1 CDC37 PHIP PDE5A CCT7 VIM HNRNPC RBMX DBN1 SRRM1 DDX39B UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM6 MCM2 GINS1 GINS2 CDC45 MCM8 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing FURIN PCSK6 PCSK5 NGF LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1 TGFBR2 TGFB1 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling FKBP1A TNRC6A PRKAG1 TNRC6B PRKAG2 CAB39L RPTOR STK11 EEF2K PRKAG3 STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD AKT1S1 CAB39 EIF4EBP1 PGK1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 EIF4G1 LAMTOR5 YWHAB RPS6 AKT2 AKT3 AKT1 PRKAB2 MLST8 PRKAB1 PRKAA1 PRKAA2 MOV10 AGO3 AGO4 AGO1 MTOR AGO2 TNRC6C DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy ACY1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 SV2C SYT1 SV2B SV2A VAMP1 VAMP2 STX1A APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated APC TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters SLC34A1 SLC34A3 SLC34A2 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CHUK IKBKB IKBKG REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) RAN FASN TM7SF2 GGPS1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK INSIG2 SAR1B RXRA INSIG1 ACACB ACACA PMVK SCAP SC5D PPARA FDFT1 FDPS MBTPS1 SEC24B SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SEC24D KPNB1 SEC24C SMARCD3 MBTPS2 CHD9 HELZ2 TGS1 TBL1X NCOA1 MED1 NCOA2 CREBBP NCOA6 TBL1XR1 CARM1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor CALM1 DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell HGS EPS15 MET STAM2 SH3GL2 SH3GL1 UBA52 UBB SH3GL3 SH3KBP1 UBC STAM RPS27A CBL MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBB UBA52 UBC RPS27A REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis GSDMD TNFRSF10B GZMB TNFRSF10A ITCH CHMP2B CHMP2A FAS CYCS FASLG UBA52 BAX STUB1 OGT GSDME UBB UBC RPS27A CASP3 TP53 MLKL TRADD HMGB1 UBE2L3 CASP8 CASP5 CASP4 FLOT1 TNFSF10 CASP1 FLOT2 TP63 PDCD6IP RIPK3 IL18 TRAF2 IL1A IRF1 IL1B IRF2 HSP90AA1 CDC37 PELI1 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 FADD BAK1 ELANE DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway VLDLR FYN SH3KBP1 RELN DAB1 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation ATP5MC2 ATP5MC3 MICOS13 MICOS10 ATP5MC1 MT-ATP6 APOO ATP5F1A CHCHD3 SAMM50 ATP5F1B CHCHD6 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME DMAC2L HSPA9 ATP5PF ATP5PD MTX1 APOOL MTX2 ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D MT-ATP8 ATP5F1E TMEM11 ATP5PO RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex UBA52 POLE RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 RPS27A RBX1 PCNA POLD3 POLD4 POLD1 POLD2 WDR48 USP1 UBE2B CUL4A RPA1 DDB1 RPA2 DTL RAD18 POLE4 CUL4B RPA3 POLE2 POLE3 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis CALM1 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 RYR3 SLC8A2 SLN NOS1 CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 TRDN ASPH STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ATP1A3 ITPR2 ATP1A2 ITPR3 ATP1A1 SRI PLN TNNI3 CAMK2G KCNJ11 DMPK ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 FXYD4 FXYD3 FXYD2 FXYD1 FKBP1B FXYD7 FXYD6 TRPC1 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC15 RB1 ANAPC16 ANAPC7 UBE2C UBE2E1 FZR1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S SKP2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence CBX6 PHC2 ATM ACD EZH2 PHC1 H2AX CBX4 ANAPC15 CBX2 ANAPC16 HMGA2 ANAPC7 H1-1 UBE2C PHC3 H1-0 UBE2E1 H1-3 UBE2D1 H1-2 ANAPC10 HMGA1 H1-5 ANAPC11 H1-4 IL6 CDC23 MDM2 UBE2S MDM4 CDC26 CXCL8 CDC27 BMI1 H3-3B CDC16 CABIN1 VENTX ANAPC4 KDM6B H3C8 ANAPC5 RING1 FOS ANAPC1 MINK1 ANAPC2 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP CEBPB RNF2 HIRA MAPK9 MAPK8 H3C15 MAPK7 UBN1 MAP4K4 RB1 CDKN2D CDKN1A CDKN2B CDKN1B CDKN2C CDKN2A FZR1 IFNB1 SUZ12 MAPK10 H2BC9 H3-4 E2F1 H2BC8 E2F2 H2BC5 E2F3 H2BC3 MAPK1 STAT3 CDK6 H2BC1 TFDP1 MAPK3 CCNE2 TFDP2 CDK4 CCNE1 CDK2 H2AB1 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 MAPKAPK3 MAPKAPK2 SP1 H2BC26 H2BC21 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 IL1A H2BC11 RBBP4 RBBP7 H2AZ2 TNRC6C TNRC6A TNRC6B JUN UBA52 LMNB1 RELA RPS6KA1 UBB UBC RPS27A NFKB1 ID1 MRE11 KAT5 TP53 NBN H2AC19 H2AC14 H2BC12L EHMT2 EHMT1 ETS1 ETS2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 MAP2K4 H4C9 TINF2 ERF MAPKAPK5 TNIK ASF1A MOV10 TXN AGO3 RAD50 EP400 AGO4 IGFBP7 H2AC20 MAP2K7 AGO1 MAP2K6 CBX8 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1C RB1 CDKN1A CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) SOS1 PIK3R1 PIK3CA NTRK2 RAC1 DOCK3 BDNF NRAS GAB1 FRS3 GRIN2B HRAS NTF4 CDK5 TIAM1 NTF3 PLCG1 FRS2 CDK5R1 SRC PTPN11 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes SP1 NOTCH1 EP300 MAFK EGF BCL2 PDGFA NFE2L2 AREG CREBBP BCL2L1 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 EEF1B2 RPL37 RPS11 EEF1G EEF1A1 EEF1D RPL39 EEF1A2 RPS10 EEF1A1P5 RPS13 EEF2 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) AKT2 AKT3 AKT1 TSC2 TSC1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer NOTCH1 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 ADAM17 NEURL1 MIB2 UBB UBC RPS27A CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling THEM4 MAP3K14 PRR5 AKT2 PIK3CD AKT3 PIK3CB AKT1 PIK3CG MLST8 TRIB3 PDPK1 MAPKAP1 RICTOR PIK3R3 PIK3R2 PIK3R1 PIK3CA PIK3R6 LCK PIK3R5 CD86 FYN CD80 MAP3K8 MTOR CD28 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 NUP37 NUP107 GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 NUP160 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE NUP85 GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 TGS1 SNUPN SEC13 NUP133 NUP205 POM121 NUP188 AAAS BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives ALOX5 PTGS2 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 ABCC8 ABCC9 KCNJ11 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 C3 C4A C5 C4B_2 CFB C2 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion PNLIPRP3 GUCY2C PNLIPRP1 PNLIPRP2 CHIA MGAM AMY2A AMY2B AMY1A TREH AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF CLPS SI PIR ALPI LCT PNLIP RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 ZNF385A PSMD12 PSMD11 COP1 PSMD14 PCBP4 PSMD13 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN1B CDKN2A CCNE2 CCNE1 CDK2 TP53 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity SKP2 RBX1 MAFK UBB UBA52 BACH1 UBC RPS27A FBXL17 CUL1 SKP1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC1A5 SLC7A11 SLC1A6 SLC6A20 SLC7A10 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC36A4 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC6A6 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein MGAT1 MGAT2 GOLGA7 ST3GAL1 TMEM258 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MAGT1 MOGS ZDHHC11 MGAT4C ZDHHC9 MGAT4A OST4 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 OSTC STT3A STT3B RPN2 DDOST RPN1 DAD1 ST6GALNAC2 PRKCSH ZDHHC20 CANX ZDHHC5 TUSC3 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission CALM1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B PPM1E PPM1F GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 CAMK4 NEFL CAMK1 CAMK2G CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response RHBDF2 MYH9 FURIN ADAM17 MAPK14 IL10 IL6 CD163 PLK2 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site CALR CANX ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway TIFA TAB3 TAB2 ALPK1 TAB1 UBB TRAF6 UBA52 UBC RPS27A MAP3K7 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MAD2L1 BUB1B GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway EZH2 H2AX PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 H3-3B TEAD4 H3C8 FOS H2AJ YAP1 H3C15 RICTOR SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 PRR5 GSK3B DPY30 H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PRKAA1 PRKAA2 LEF1 RBBP4 RBBP5 RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C TNRC6A TNRC6B CCNK CCNT2 ELL CCNT1 TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP CTDP1 TAF9 SUPT4H1 TAF1L TAF15 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TP53 TGFB1 PARP1 BLK ELF1 ELF2 CBFB PAX5 RUNX1 SOX2 ZNF521 TRPC3 PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYA NFYB NFYC GPAM SP1 CASP1 TP63 TNFRSF10B TNFRSF10A ITCH FAS CYCS BAX STUB1 PRKACA CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM2 MDM4 BMI1 VENTX RING1 CCNA2 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PRMT5 PHF20 CHEK2 ZNF385A PCBP4 GRIN2A CAMK4 PLK2 MDC1 SPI1 MT-CO1 RBPJ NOC2L ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 SCO2 ZNF705EP DDIT3 DDIT4 TXNIP MT-CO2 MT-CO3 MYL9 ZNF28 ZNF274 ZNF273 MEAF6 ZNF20 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 ZNF26 SFN ZNF268 PPARGC1B ZNF267 PRELID3A ZNF266 ZNF264 ZNF263 ABCA6 NR2F1 ZNF34 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 BBC3 MED12 MED14 MED13 HEY1 CASP10 MED10 ZNF41 HEY2 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 CNOT6L ACTL6B ZNF480 ACTL6A MED27 MED26 SIRT3 DDB2 MED23 MED25 MED24 MMP13 MED20 ZNF479 ZNF235 ZNF234 ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT EGFR BGLAP PLAGL1 SPP1 ZNF227 ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 USP9X ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 UBE2D3 PSMD8 RORC RORB PSMD6 YY1 PSMD7 SESN3 PSMD2 ZNF208 PSMD3 SESN2 PSMD1 ZNF205 ZNF689 KMT5A ZNF688 ZNF446 SKP1 ZNF445 PITX2 PRKCB ZNF202 PSMA5 ZNF443 PSMA6 ZNF200 PSMA3 ZNF684 PSMA4 ZNF442 PSMA1 ZNF441 PSMA2 BNIP3L ZNF682 UBA52 ZNF440 ZNF681 PSMD12 ZNF680 PSMD11 ZFP69B PSMD14 FOXP3 PSMD13 NPAS4 CUL1 MAF PSMA7 ZNF439 ZNF679 RELA ZNF678 PSMB6 ZNF436 PSMB7 ZNF677 PSMB4 ZNF676 PSMB5 ZNF433 ZNF675 UBB PSMB2 ZNF432 PSMB3 PVALB ZNF431 UBC PSMB1 ZNF430 RPS27A GRIA2 KMT2D ADRM1 ZNF671 NFKB1 ZNF670 SEM1 CPAP PSMC5 MAX PSMC6 DLX5 PSMC3 DLX6 PSMC4 KMT2B PSMC1 FOXO6 PSMC2 FOXO4 FOXO1 ZNF840P ATXN3 SOCS3 MED30 MOBP ZKSCAN7 HDAC4 ZNF429 MED31 THRB ZKSCAN8 UBE2I ZKSCAN3 VDR SMYD2 NR1H2 RORA ZNF669 ZNF668 NR3C1 ZNF426 NR2C1 ZNF667 ESR1 ZKSCAN5 ZNF425 ZKSCAN4 NR5A1 ZNF665 NR4A2 AR ZNF664 ZKSCAN1 RXRA SOCS4 SUMO1 BCL2L14 ZNF662 ZNF420 RARA ZNF660 PGR PPARG BRPF1 PPARA BRPF3 TNFRSF10C FBXO32 MRE11 G6PC1 BRCA1 TNFRSF10D RGCC ZNF419 KAT5 ZNF418 EXO1 ZNF417 ZNF658 ZNF416 CHEK1 ZNF415 NBN PIN1 TOPBP1 ZNF655 SP7 PPP1R13B COX4I1 COX4I2 RFC5 PTEN RFC3 RMI2 ITGAL PPP1R13L RFC4 ZNF649 DGCR8 YAF2 RFC2 RMI1 NKX3-2 ZNF641 TOP3A TRIM63 HUS1 APAF1 ITGA4 TNFRSF18 RAD51D ARNT RABGGTB DNA2 RABGGTA RHNO1 BLM RRM2B HAND2 ZNF875 PCNA ITGA5 SRF PPM1D WRN ZNF627 ZNF626 BRIP1 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 RBBP8 ATRIP E2F5 ZNF620 BARD1 E2F6 E2F7 E2F8 RPA1 ZNF860 RPA2 PTPN1 MGA TBX5 RAD50 PINK1 RAD51 ZNF619 RPA3 SST IL2RA ZNF616 RAD17 SYT10 RAD1 ZNF615 ATM ZNF614 RAD9B ZNF613 ATR ZNF611 RAD9A PTPN4 ANAPC15 ZNF610 ANAPC16 ANAPC7 TRIM33 SMARCB1 UBE2C CCNC UBE2E1 UXT UBE2D1 LGALS3 ZNF729 ANAPC10 TRIM28 ANAPC11 ZNF727 CCNB1 CDC23 ZNF726 ZNF724 UBE2S CDC26 EPC1 CDC27 CCN2 ZNF721 CDC16 SMARCC1 CDK1 ANAPC4 SMARCC2 ANAPC5 ZFP1 ANAPC1 ZFP2 ANAPC2 ZNF718 ZNF717 ZNF716 SRC ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 ZNF324B CTNNB1 L3MBTL2 FOXG1 MET TGFA ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 YWHAB APOE PCK1 CRADD IQSEC3 MAPK1 SMARCA2 SMARCA4 SNW1 MAPK3 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C MAPK14 CTSL CTSK HNF4A COX8A MAPK11 SREBF1 COX8C PBRM1 SATB2 COX5B COX5A RXRB ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 COX6C GCK ATF2 VEGFA TTC5 CCNG2 CCNG1 HDAC3 MAMLD1 ZFP28 SMARCD3 PRDM7 PRDM1 COX6A1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 XPO1 COX6B2 GEM COX6B1 ZNF92 EP300 GPRIN1 NDRG1 TBL1X HIGD1C IRAK1 TFAP2A PPARGC1A TFAP2B ZFHX3 TFAP2C MED1 TFAP2D CREBBP AUTS2 MEF2C TFAP2E CNOT10 IL2 IL3 BMP2 NR1D1 SIRT1 CNOT11 TCF3 NCOR1 DYRK2 TBL1XR1 LDB1 CARM1 CHD4 CHD3 TRIAP1 BMAL1 PIDD1 YWHAQ MYBL2 TGIF1 ZNF75CP RBM14 TGIF2 CAT TMEM219 RETN NFATC2 AURKA INS CALM1 MTA2 RRM2 YWHAE ZNF804B REST JUN KRAS FASLG ZNF175 SOD2 MAML2 CDC25C MAML1 FOXO3 SERPINE1 GLS NAMPT ZSCAN32 MYB PIP4K2A PRDX2 BCL2L11 PIP4K2B JUNB CDK5 ZNF169 RNF111 GAMT PRDX1 ZNF705G ZNF705D ZNF160 CDK5R1 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 NOTCH1 RBX1 ZNF155 ZNF154 ZNF394 NEDD4L NKX2-5 NR2C2AP NFE2 IHH PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 SETD1B SETD1A CDC7 NR1D2 ZNF37A ZNF702P ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET GPI BTG2 RARG BTG1 SETD9 CRH CHM GLI3 GLI2 ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 RSPO3 ZNF124 ZIK1 BRD2 BRD1 TCF12 NCOR2 KAT2B KAT2A TAL1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 GPS2 ZNF589 ZNF347 BRD7 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 WWOX ZNF582 PCGF6 TIGAR PCGF5 PCGF2 WWP1 HIPK1 POU4F1 POU4F2 ZNF33B HIPK2 ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 ITGA2B YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 MEN1 ZNF563 IGFBP1 ZNF562 GAD1 ZNF320 GAD2 ZNF561 USP7 ZNF560 IGFBP3 USP2 NRBP1 KAT6A ZNF559 ZNF317 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 NOTCH2 ZNF793 ZNF551 CSF1R RB1 ZNF792 CDKN1A NOTCH3 CDKN1B ZNF550 CCND3 ZNF791 ZNF790 FZR1 CCND2 NOTCH4 CCND1 ZNF767P E2F1 ZNF549 ZNF548 ABL1 ZNF547 SKP2 DAXX ZNF546 ZNF304 ZNF544 CDK6 ZNF786 TFDP1 CCNE2 ZNF302 ZNF785 TFDP2 ZNF543 CDK4 CCNE1 SKIL ZNF300 CDK2 PLXNA4 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC PPP2R1B CNOT4 PPP2R1A CDK8 ZFP69 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 ZNF774 CNOT9 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 SIN3A ZNF528 ZNF764 LBR ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 HDAC2 SMARCD2 PPP2R5C RNF34 GLS2 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 BIRC5 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 AURKB KCNIP3 KLF4 PML ZNF738 PPP2CA ZNF737 PPP2CB ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 TP53AIP1 ZNF607 ZNF606 ZNF605 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 CITED1 CITED2 CITED4 PRMT6 KRABD5 KRABD4 PRMT1 MSH2 KRABD3 GP1BA PMS2 SGK1 ZNF2 MLH1 ZNF3 NPY ARNT2 ZNF354A ZNF354C ZNF354B STEAP3 LMO1 LMO2 TJP1 KCTD1 OCLN ATP1B4 LIFR KCTD6 FANCD2 COXFA4 NOP2 COX7A2 CCNH COX7A1 PMAIP1 POLR2A SMAD2 POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E CBX5 POLR2F SMURF2 POLR2G CBX3 POLR2H SMURF1 POLR2I SMAD6 POLR2J ESR2 POLR2K SMAD7 POLR2L NR4A1 TP53I3 GTF2H1 NR4A3 GTF2H2 JMY SUPT5H KDM5B GTF2H3 THRA GTF2F1 CGB8 GTF2F2 SLC2A3 GTF2H4 NR2E1 GTF2H5 YBX1 CDK7 CASP6 ERCC3 CASP2 ERCC2 AXIN1 MNAT1 OPRM1 ARID1A ARID1B RBL2 H2AC19 RBL1 H2AC14 IFNG H2BC12L ZNF197 AKT2 ZNF195 MYC NR2C2 AKT3 THBS1 HSPD1 AKT1 ERBB2 HES1 PRKAB2 ZNF189 CSNK2A1 ZNF286A CSNK2A2 ZNF184 PRKAB1 ZNF180 CSNK2B OPRK1 ARID3A DEK MAPKAP1 WWTR1 YES1 H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins ALOX5 HPGD LTA4H XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics CYP2C19 CYP3A4 ARNT CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 ARNT2 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP2E1 CYP2F1 CYP2J2 CYP3A43 AHR IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport UBA52 CUL1 STEAP4 TFRC HFE SLC40A1 TCIRG1 HEPH UBB SLC22A17 FTH1 ATP6V1E1 UBC ATP6V1E2 ATP6V0B RPS27A ATP6V1G1 ATP6V0E1 ATP6V1G2 GLRX3 ATP6AP1 SLC11A2 TFR2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 FTL ABCG2 STEAP3 ATP6V1B1 ATP6V1A IREB2 NEDD8 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 CYBRD1 CP TF LCN2 ACO1 SLC46A1 FBXL5 HMOX1 MCOLN1 SKP1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 CCNE2 CCNE1 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN ZBP1 TBK1 IRF3 NLRP4 DTX4 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPO CA9 ARNT EP300 HIGD1A EPAS1 CREBBP CITED2 HIF1A VEGFA BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA DBT BCKDHB DLD COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization COL9A2 COL6A5 COL1A1 COL1A2 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 COL3A1 COL2A1 COL4A2 COL5A1 COL4A1 COL7A1 COL6A2 COL5A3 COL4A4 COL5A2 COL6A1 COL4A3 COL4A6 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism HDLBP FURIN PCSK9 PCSK6 AP2A1 PCSK5 LIPA AP2A2 LIPC CREB3L3 PRKACG UBA52 LIPG LDLRAP1 PRKACB AP2M1 MYLIP CUBN VLDLR AMN APOA2 APOA4 LSR APOA5 NPC1 SOAT1 SOAT2 NPC2 UBB ANGPTL8 ANGPTL3 ANGPTL4 UBC LPA CES3 RPS27A ABCG1 CETP MTTP LCAT LPL LMF2 LMF1 AP2S1 APOF A2M LDLR GPIHBP1 FGF21 ABCA1 APOC4 NR1H3 APOE APOBR APOC3 AP2B1 NCEH1 APOC2 NR1H2 APOC1 ALB P4HB ZDHHC8 SAR1B PRKACA MBTPS1 MBTPS2 APOB CLTC CLTA APOA1 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) GUSB NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration ACO1 IDH1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism B3GNT3 PCK1 CTSL GCK SLC9A1 G6PD CALM1 PRKACG PRKACB SLC35B3 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 GPI ENO1 ENO2 HS6ST1 ST3GAL4 ENO3 ENO4 HS6ST2 HS6ST3 ST3GAL1 NDST2 ST3GAL2 NDST1 ST3GAL3 NDST4 NDST3 XYLB GAPDHS GLCE OMD ABCC5 TALDO1 PHKA1 PHKA2 HSPG2 PPP1R3C NHLRC1 HS3ST3A1 SDC4 SDC2 SDC3 SLC35D2 GNS ABO CHST11 CHST12 CHST15 CHST13 ST3GAL6 CHST14 B4GALNT2 PCK2 DERA EXT1 EXT2 B4GAT1 SDC1 PYGB GBE1 STAB2 AKR1B1 PYGM PYGL KHK GYS2 GYS1 HYAL2 B3GALT2 B3GALT1 MANBA CHST6 CHST7 TPI1 GAA PGAM1 PGAM2 AKR1A1 PGM2L1 B3GNT7 NUP205 B3GNT4 POM121 FAM20B CHST1 NUP188 B3GNT2 AAAS ALDOC POM121C ALDOB ALDOA NUP42 TKT NUP62 CHST5 TPR CD44 NUP88 SPAM1 CHST2 RAE1 CHST3 NUP214 PAPSS2 NDC1 RHD NUP210 PAPSS1 EXTL2 NUP155 GPC1 HAS1 NUP153 NUP93 HAS3 GPC3 NUP50 SLC17A5 NUP35 IDUA GPC2 NUP54 HEXB HAS2 NCAN GPC5 HEXA GPC4 BGN EXTL3 GPC6 DCN AGL GLB1L3 PGK1 GLYCTK GLB1L2 BCAN LYVE1 FMOD VCAN GLB1L AGRN CHPF GLB1 HYAL1 NAGLU HYAL3 CHP1 HYAL4 SLC26A11 GYG2 CSPG5 IDS GYG1 CSGALNACT1 CSPG4 EPM2A GUSB ARSB CSGALNACT2 AKR1E2 KERA PGD SHPK RHCE PFKFB2 PFKFB1 SLC26A2 PFKFB4 CEMIP PFKFB3 SLC26A1 HMMR FUT2 FUT1 FUT4 FUT3 FUT6 FUT5 TKFC FUT7 FUT9 DSEL NUP107 PGK2 GCKR SLC37A1 B3GALT4 PHKB B3GALT6 PPP2R1B B3GALT5 PPP2R1A G6PC2 G6PC3 MAN2B2 UST OGN CRYL1 MAN2B1 HPSE GALK1 B4GALT2 B4GALT3 B4GALT1 ADPGK SLC2A1 HK2 NUP160 SGSH HS2ST1 HK1 HK3 DSE NUP85 PGM2 PGLS MAN2C1 SLC37A4 PGM1 HS3ST3B1 CHPF2 DCXR SORD BPGM HKDC1 ALDH1A1 PXYLP1 LALBA B4GALT6 SEC13 GAPDH B4GALT7 NUP133 FBP1 FBP2 RBKS PPP2R5D B4GALT4 B4GALT5 ST6GALNAC6 PRPS2 PRPS1 GALT RPEL1 RPE PRELP ACAN UGP2 CHSY1 PHKG1 PHKG2 CHSY3 PRPS1L1 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 PPP2CA HS3ST6 PPP2CB HS3ST4 NUP43 HS3ST1 HS3ST2 GALNS RPIA PFKL GALE RANBP2 GNPDA1 UBA52 PC GNPDA2 GALM PFKM PFKP UBB UBC RPS27A NUP37 PRKACA G6PC1 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 SRGAP3 SRGAP2 SRGAP1 CDC42 ROBO1 RAC1 ARHGAP39 SLIT2 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTF3 NTRK2 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TBK1 UBA52 TICAM2 TICAM1 TANK TLR4 LY96 TRAF3 UBB CD14 IKBKE OPTN UBC RPS27A ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation ADH1B ADH1A ALDH1A1 ADH7 ACSS1 ADH5 ADH6 ADH4 ACSS2 ALDH2 ALDH1B1 ADH1C FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants FLT3LG UBB UBA52 FLT3 UBC RPS27A CBL DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 PPARG MTA2 PPARA PPARGC1B MBD3 GATAD2B GATAD2A UCP1 PPARGC1A HNRNPU NCOA1 MTA1 HDAC1 PRDM16 HDAC2 ZNF423 MTA3 ELOVL3 CIDEA EBF2 BMP7 CHD4 RBBP4 CHD3 COX7A1 RBBP7 SMAD1 SMAD4 RXRA SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins NFKBIA UBE2I TOPORS RELA IKBKE EIF2AK2 IKBKG PIAS4 SUMO1 PIAS3 SUMO3 NFKB2 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK HPRT1 AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP ADA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins GSK3A MGAT1 PARP6 PARP4 ST3GAL1 GALNT1 ST3GAL2 PARP16 ST3GAL3 PARP9 ST6GAL1 PARP14 PARP8 MOGS PARP10 UBA52 ST6GALNAC3 ST6GALNAC4 GSK3B UBB UBC RPS27A UBE2I ST6GALNAC2 PRKCSH CANX GANAB SUMO1 ST3GAL4 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway NFATC1 TNRC6A CALM1 TNRC6B CTNNB1 GNGT1 GNGT2 WNT5A GNAT2 TCF7 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 PLCB2 NLK PDE6B CAMK2A GNG10 PDE6A GNG3 PDE6G ITPR1 GNAO1 GNG2 ITPR2 WNT11 GNG5 ITPR3 GNG4 GNG7 GNG8 FZD3 FZD2 FZD5 FZD4 FZD6 LEF1 GNG12 GNG11 GNG13 GNB2 MOV10 GNB1 PPP3CA TCF7L2 AGO3 PPP3CB AGO4 GNB4 TCF7L1 GNB3 AGO1 GNB5 MAP3K7 AGO2 PPP3R1 TNRC6C TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors YEATS4 PITX2 CGA KDM5B CGB8 NPM1 EGFR VEGFA MYC CITED1 HSPD1 CITED2 ERBB2 CITED4 ATAD2 KCTD15 EP300 DEK TGFA TFAP2A CDKN1A TFAP2B KIT WWOX TFAP2C TFAP2D CREBBP TFAP2E APOE KCTD1 UBE2I NOP2 YY1 ESR1 MYBL2 SUMO1 DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS MAOA ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs ALK EML4 FN1 PPM1B HIP1 PRKAR1A CLTC BCL11A NPM1 EIF2AK3 STRN BIRC6 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism PRODH PRODH2 ALDH4A1 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication POM121C NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 NUP107 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 NUP160 RPS4Y2 RPS4Y1 RPL39L NUP85 RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 GRSF1 RPS21 SEC13 RPS24 RPS23 NUP133 RPLP1 RPLP0 RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 NUP43 RPS2 RPL18 RPL17 RPL19 RPL35A RANBP2 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A NUP37 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 NUP205 POM121 NUP188 AAAS ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP2B CHMP2A UBA52 UBB UBC RPS27A STAM HGS STAM2 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C CHMP4C VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A SNF8 CHMP6 UBAP1 CHMP7 VPS25 VPS28 CHMP5 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known CBX6 PHC2 PBRM1 PHC1 CBX4 CBX2 SMARCB1 PHC3 ARID1A BMI1 ARID1B CBFB SMARCD3 SMARCC1 SMARCC2 RUNX1 RING1 ARID2 YAF2 CSNK2A1 RNF2 CSNK2A2 CSNK2B EP300 SMARCD1 AUTS2 SMARCD2 PCGF5 SMARCA2 SMARCA4 HIPK2 RYBP ACTL6B ACTL6A SMARCE1 CBX8 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 TUFM MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints ATM FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 ZNF385A PSMD12 PSMD11 COP1 CDC25A PSMD14 PCBP4 PSMD13 CUL1 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN1B PLK3 CDKN2A CCNE2 CCNE1 CDK2 MAPK14 MAPK11 TP53 CHEK1 CSNK1E CSNK1A1 NEK11 GSK3B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) FKBP1A TGFBR1 TGFBR2 UBA52 ARHGEF18 CGN F11R PRKCZ UBB TGFB1 RHOA PARD6A PARD3 UBC RPS27A SMURF1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis POM121C POLR2I NUP42 POLR2J NUP62 NUP43 POLR2K TPR POLR2L NUP88 RAE1 NUP214 RANBP2 NDC1 GTF2F1 NUP210 GTF2F2 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 POLR2A POLR2B POLR2C NUP205 POLR2D POM121 NUP107 POLR2E NUP188 POLR2F POLR2G AAAS POLR2H CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling RPS6KA5 CD209 EP300 PAK1 PRKACA PAK3 PRKACG PAK2 CREBBP PRKACB NRAS LYN RELA HRAS FYN RAF1 ICAM2 ICAM3 NFKB1 RELB ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 RAB7A EPHA2 VAMP3 ARHGEF26 GARRE1 SHMT2 PLD1 IQGAP2 KALRN ARHGAP39 ARHGAP21 LMAN1 STX5 YKT6 PAK4 NDUFA5 TFRC MCF2 MCAM ERBIN HSPE1 VAV1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 VAPB ESYT1 PAK2 DOCK3 DSG2 CAV1 VAV3 VAV2 LBR PGRMC2 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO PIK3R1 ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 CDC42 MCF2L ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 RHOG MAP3K11 VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism PPP1CC PRKACA PRKACG PRKACB GPAM MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 CAV1 PLIN3 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 MGLL LPIN3 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors YEATS4 EP300 TFAP2A TFAP2B WWOX TFAP2C TFAP2D CITED1 CREBBP CITED2 TFAP2E CITED4 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose GMPPB PMM1 GMPPA PMM2 MPI HK1 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PPP2CA CHUK PPP2R1B PPP2R1A PPP2R2A PIEZO1 ITGAV ANXA2 PTK2 GNAQ RELA CAPNS1 CAPNS2 CAPN2 IKBKE YAP1 NFKB1 NFKBIA ITGB1 ITGB3 ITGA5 ABL1 STAT1 GNA11 IKBKB PTPN1 VCL IKBKG DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 ABCA3 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBA52 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF UBB UBC RPS27A CBL SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors RAC1 SRC PAK1 PAK3 PAK2 SOS1 RHOA CDC42 LDB1 PPP3CB COL4A5 PRKACG PRKACB ELOB ELOC PAK4 NCBP1 NCBP2 RBX1 DAG1 HOXA2 ISL1 PFN1 PFN2 GSPT2 GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH PABPC1 CXCR4 AKAP5 ZSWIM8 PAK6 PAK5 CAP2 MYO9B MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 GPC1 EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 ABL1 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 CLASP1 PSMA4 RPL19 PSMA1 CLASP2 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 PSMD14 ARHGAP39 PSMD13 SLIT2 SRGAP3 PSMA7 SRGAP2 SRGAP1 ROBO1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4A3 CASC3 MAGOH PRKACA RBM8A PRKCA UPF3B MAGOHB RNPS1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SLC35C1 ALG5 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS SLC17A5 AMDHD2 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA NUS1 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 GLB1 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ST6GALNAC2 MVD ST3GAL4 GMPPB PMM1 GMPPA ST3GAL1 PMM2 MPI ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 ST6GALNAC4 HK1 ST3GAL6 ST6GALNAC6 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry FURIN TMPRSS2 SDC1 VCP ACE2 HAVCR1 GPC1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 NRP1 AGRN CTSL ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling TGFA ELK1 CDKN1B EREG SRF PTK2 UHMK1 BTC EPGN FOXO3 CCND1 HBEGF EGFR MAPK1 MAPK3 FOS EGF AKT2 BCL2 AKT3 AREG AKT1 XPO1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival NFKBIA IRAK1 UBA52 NGFR SQSTM1 RELA IKBKB UBB TRAF6 UBC NGF RPS27A NFKB1 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis DDC TH DBH PNMT CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis CSPG5 CSGALNACT1 CSPG4 CSGALNACT2 UST CHST3 CHST7 NCAN BGN DCN CHSY1 CHST11 BCAN CHST12 CHSY3 VCAN CHST15 CHST13 CHPF CHPF2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 CHMP2A APP AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 GNS HGS SH3GL2 ARRB1 CLTC VAMP2 CLTA ARF1 CTSZ AP4E1 CLTB AP4M1 AP1G2 BLOC1S1 CLVS2 AP4S1 CLVS1 TXNDC5 HSPA8 M6PR METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation HEMK2 NNMT MTRR AHCY TPMT GSTO1 MTR MAT1A MAT2B COMT CYP1A2 TRMT112 AS3MT MAT2A INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins CDK9 CCNT1 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling SOS1 THEM4 KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS ABCC2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 ITGB1 LAMA4 LAMA3 ITGAV LAMC2 LAMB1 LAMC1 ITGB4 ITGA3 HSPG2 ITGA2 ITGA1 NID1 NID2 ITGA7 ITGA6 COL18A1 LAMA5 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis H2AX GATA2 MYB H3-3B CBFB H3C8 RUNX1 H2AJ CEBPB H3C15 CDKN1A H2BC9 E2F1 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 TFDP1 TFDP2 CDK4 CDK2 H2AB1 RXRA H2AC8 H2AC6 H2AC7 RARA KMT2A TAL1 H2AC19 H2AC14 H2BC12L MYC H2BC26 H2BC21 EP300 DEK H2BC17 SPI1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 LEF1 H4C9 CSF3R GFI1 IL6R CEBPA CEBPE FLI1 H2AZ2 KLF5 H2AC20 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation UBE2O TPP2 BLMH UBA1 UBE2K UBE2M TRIM71 ANAPC7 RNF14 UBE2C KBTBD13 UFL1 UBE2E1 UBE2Q1 UBE2D1 UBE2Q2 ANAPC10 TRIM69 ANAPC11 UNKL DTX3L CDC23 PJA2 UBE2S PJA1 CDC26 TRAF7 CDC27 UBE2R2 CDC16 THOP1 TRIM50 ANAPC4 MGRN1 ANAPC5 ASB13 ANAPC1 ASB14 ANAPC2 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 VHL TRIM41 UBE2D2 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 MIB2 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 CDC34 ASB3 ASB1 UBE2V1 UBE2N ELOB ELOC MYLIP RNF111 RBX1 NEDD4L FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 FBXL3 FBXL5 CUL2 RBBP6 WWP1 CUL3 KBTBD7 FZR1 SKP2 CDC20 UBE2L3 RNF34 UBE2D3 PSMD8 PSMD6 PSMD7 PSMD2 PRKN PSMD3 PSMD1 LRR1 CCNF BTRC KEAP1 CBLB SKP1 UBE2L6 HERC5 DCAF1 FBXW11 HERC4 PSMA5 HERC3 PSMA6 ITCH RNF115 PSMA3 HERC2 PSMA4 RNF114 PSMA1 HERC1 PSMA2 TRIM21 UBA52 FBXO7 STUB1 HERC6 PSMD12 FBXO9 PSMD11 WSB1 PSMD14 FBXO2 PSMD13 RNF123 CUL1 RNF126 HECW2 PSMA7 RBCK1 CBLL2 TRIM11 PSMB6 ANAPC13 PSMB7 UBE2J2 PSMB4 UBE2J1 PSMB5 RNF213 UBB RNF217 PSMB2 ATG7 PSMB3 HACE1 UBC SIAH2 PSMB1 SIAH1 RPS27A LNPEP ADRM1 MEX3C UBAC1 SEM1 FBXL8 FBXL4 PSMC5 DZIP3 PSMC6 FBXL7 PSMC3 RNF220 PSMC4 DET1 PSMC1 LRSAM1 PSMC2 SH3RF1 TRIM9 TRIM4 ARIH2 SOCS3 LRRC41 RNF144B GAN RNF138 RNF130 HUWE1 KCTD6 KLHL2 UBE2G1 KLHL3 UBE2B UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 SMURF2 KBTBD8 SPSB4 SMURF1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A FBXO32 UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 TRIM63 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 RNF182 UBA3 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 XRN2 GAPDHS FKBP9 TP53 CCT6A HDAC3 FBXL3 FBXL5 WRAP53 KIF13A CCT3 CCT2 SPHK1 SKIC2 TCP1 USP11 AP3M1 STAT3 GBA1 CCT8 CCT7 DCAF7 CCT5 CCT6B CCT4 CCNE2 NOP56 ARFGEF2 CCNE1 FBXO4 LONP2 FBXO6 FBXW4 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 FBXL21P PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CRY2 CRY1 PER2 PER1 PER3 FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 MET ITGB1 LAMA4 LAMA3 LAMC2 LAMB1 PTK2 LAMC1 ITGA3 ITGA2 HGF SRC LAMA5 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PATJ PALS1 CRB3 TJP1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 FGFBP1 FGF1 FGFBP2 FGF2 FGF3 FGFBP3 FGF4 FGF6 FGF7 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency GSS SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle CDC42EP1 IL32 GIT2 ARHGAP26 BAIAP2 TAOK3 RAB7A ABI2 EPHA2 NOXA1 VAMP3 ABI1 NOX3 GARRE1 NOX1 FERMT2 ARHGAP39 ARHGAP21 LMAN1 SRGAP2 YKT6 PAK4 TFRC MCF2 MCAM ERBIN SLC1A5 MPP7 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 ESYT1 PAK1 PAK2 DSG2 TIAM1 CAV1 RAPGEF1 JAG1 VAV2 LBR PGRMC2 NCKAP1 NCF1 NCF2 NCF4 SNAP23 ITGB1 BRK1 ABL2 CYFIP1 ARHGAP6 DOCK10 SYDE1 ARHGAP42 PIK3R2 TRIO BAIAP2L1 PIK3R1 RAC3 ARHGAP1 GIT1 SWAP70 ARHGAP5 ARAP2 ARHGAP35 CYBB PREX1 ARAP3 OPHN1 OCRL CYBA STBD1 BCR CDC42 AMIGO2 ARHGDIB NOXO1 EMD ARHGAP17 TMPO ARHGAP15 ABR RACGAP1 SLITRK3 VRK2 NHS LEMD3 SLITRK5 NCKAP1L DEPDC1B WASF1 WASF2 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 SPP1 CBFB ITGAL RUNX3 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death EZH2 H2AX CAST YWHAE APP JUN FASLG SOD2 C1QBP CDC25C DNMT3B FOXO3 GSDME DNMT3A CDC25A CDC25B PRIM2 LMNB1 DNMT1 GOLGA2 PRIM1 PRDX2 POLA1 H3-3B BCL2L11 POLA2 CDK5 CAPNS1 CAPNS2 H3C8 PRDX1 CAPN2 CAPN1 H2AJ CDK5R1 H3C15 CDKN2A SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 TP53 H2AC19 H2AC14 H2BC12L MLKL H2BC26 TRADD H2BC21 CASP8 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 RIPK3 TRAF2 H2BC11 H4C9 RBBP4 RBBP7 H2AZ2 RIPK1 H2AC20 FADD IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption PNLIPRP3 RSC1A1 SLC2A2 SLC5A1 SLC2A5 GUCY2C PNLIPRP1 PNLIPRP2 CHIA MGAM AMY2A AMY2B AMY1A TREH AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF CLPS SI PIR ALPI LCT PNLIP RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling PLCG1 EGF ERBB2 EGFR NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases CAST YWHAE APP JUN FASLG SOD2 CDC25C FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis PPIA THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis CD4 DOCK2 AP2A1 AP2A2 AP1G1 RAC1 AP2M1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 HCK CD8B ELMO1 AP2S1 PAK2 LCK AP2B1 ATP6V1H ARF1 FYN CD28 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis SREBF1 PMVK SC5D FDFT1 FDPS CYP51A1 SQLE DHCR7 LBR IDI2 MSMO1 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 PLPP6 TM7SF2 GGPS1 HMGCS1 LSS SREBF2 MVD IDI1 MVK DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation UPK1A EPCAM TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 RAD1 ATM RAD9B ATR PRKAG1 RAD9A PRKAG2 PRKAG3 CCNB1 MDM2 MDM4 CDK1 FOS CCNA2 CCNA1 L3MBTL1 RICTOR CDKN2A YWHAB CRADD TP73 COX7B COX7C MAPK14 COX8A MAPK11 COX8C COX5B COX5A PERP NPM1 COX6C ATF2 TTC5 PRMT5 CCNG1 PRDM1 COX6A1 PRR5 COX6A2 G6PD COX6B2 MLST8 COX6B1 YWHAG EP300 NDRG1 PDPK1 HIGD1C CREBBP CNOT10 PRKAA1 PRKAA2 CNOT11 DYRK2 CARM1 CHD4 RBBP4 CHD3 TRIAP1 PIDD1 YWHAQ RBBP7 MTOR TNRC6C TMEM219 AURKA TNRC6A MTA2 TNRC6B CCNK CCNT2 YWHAE ELL JUN CCNT1 PHF20 CHEK2 TAF7L ELOA CDC25C ZNF385A ELOB GLS PCBP4 NELFB ELOC NELFCD NELFA PIP4K2A PRDX2 NELFE PIP4K2B SUPT16H CDK5 TBP PRDX1 YWHAH CTDP1 CDK5R1 TAF9 SUPT4H1 TAF1L TAF15 TAF12 TAF13 TAF10 YWHAZ TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 PLK3 TAF4B PRELID1 HDAC1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CDK12 CDK13 GPI BTG2 SETD9 CHM ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 TP53 BRD1 BRD7 PLK2 MDC1 MT-CO1 NOC2L TIGAR HIPK1 POU4F1 POU4F2 HIPK2 SCO2 DDIT4 MT-CO2 MT-CO3 MEAF6 RPTOR SFN STK11 PRELID3A TSC2 TSC1 RRAGA RRAGC USP7 RRAGB RRAGD IGFBP3 USP2 KAT6A SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CDKN1A CDKN1B BBC3 CASP10 E2F1 DAXX TFDP1 CCNE2 CNOT6L TFDP2 CCNE1 CDK2 FANCI DDB2 PPP2R1B FANCC PPP2R1A CNOT4 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 CNOT8 PLAGL1 CNOT9 BID MBD3 GPX2 GATAD2B GATAD2A CASP1 TP63 HDAC2 PPP2R5C RNF34 GLS2 NLRC4 BIRC5 SESN3 RFFL SESN2 TXNRD1 KMT5A AURKB PML PPP2CA PPP2CB TNFRSF10B TNFRSF10A TP53RK FAS BNIP3L CYCS TP53AIP1 UBA52 BAX COX7A2L NUAK1 TP53BP2 BANP GADD45A UBB TPX2 UBC RPS27A PRMT1 MSH2 CPAP SGK1 PMS2 MLH1 STEAP3 FANCD2 COXFA4 SMYD2 COX7A2 CCNH COX7A1 PMAIP1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G BCL2L14 POLR2H POLR2I ZNF420 POLR2J POLR2K BRPF1 POLR2L BRPF3 TP53I3 GTF2H1 TNFRSF10C GTF2H2 MRE11 JMY BRCA1 SUPT5H GTF2H3 TNFRSF10D GTF2F1 RGCC KAT5 GTF2F2 GTF2H4 EXO1 GTF2H5 CDK7 CASP6 CHEK1 CASP2 ERCC3 NBN ERCC2 PIN1 MNAT1 TOPBP1 PPP1R13B RBL2 COX4I1 RBL1 COX4I2 RFC5 PTEN RFC3 AKT2 RMI2 PPP1R13L RFC4 AKT3 AKT1 RFC2 RMI1 PRKAB2 TOP3A CSNK2A1 HUS1 CSNK2A2 APAF1 PRKAB1 CSNK2B RAD51D ARID3A DNA2 RABGGTB RHNO1 RABGGTA BLM RRM2B MAPKAP1 PCNA WRN EHMT2 BRIP1 EHMT1 TP53INP1 E2F4 RBBP8 ATRIP BARD1 E2F7 RPA1 E2F8 RPA2 MAPKAPK5 MOV10 TXN AGO3 RAD50 AGO4 RPA3 AGO1 AGO2 MAP2K6 RAD17 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB APEX1 XRCC1 LIG3 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity MEAF6 RAD1 ATM RAD9B ATR RAD9A PRKAG1 PRKAG2 STK11 PRKAG3 MDM2 MDM4 USP7 USP2 CDK1 KAT6A CCNA2 CCNA1 L3MBTL1 RICTOR CDKN2A DAXX TP73 CDK2 MAPK14 MAPK11 PPP2R1B PPP2R1A TTC5 PRMT5 CCNG1 PRDM1 PRR5 MBD3 MLST8 EP300 GATAD2B PDPK1 GATAD2A TP63 HDAC2 PPP2R5C RNF34 PRKAA1 PRKAA2 DYRK2 CHD4 RBBP4 CHD3 RBBP7 RFFL KMT5A AURKB MTOR PML PPP2CA PPP2CB AURKA MTA2 TP53RK UBA52 PHF20 CHEK2 TAF7L ZNF385A PIP4K2A PIP4K2B SUPT16H CDK5 TBP NUAK1 TP53BP2 BANP UBB TPX2 TAF9 CDK5R1 UBC TAF1L RPS27A TAF15 TAF12 TAF13 TAF10 TAF11 SGK1 SSRP1 TAF8 TAF7 PLK3 TAF4B HDAC1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SMYD2 SETD9 BRPF1 BRPF3 ING5 ING2 MRE11 JMY PIP4P1 BRCA1 KAT5 TP53 EXO1 BRD1 CHEK1 NBN PIN1 TOPBP1 PPP1R13B RFC5 RFC3 AKT2 RMI2 PPP1R13L RFC4 AKT3 AKT1 RFC2 RMI1 PRKAB2 TOP3A CSNK2A1 HUS1 BRD7 CSNK2A2 PRKAB1 CSNK2B DNA2 RHNO1 BLM MAPKAP1 NOC2L WRN EHMT2 BRIP1 EHMT1 TP53INP1 HIPK1 POU4F1 RBBP8 POU4F2 ATRIP BARD1 HIPK2 RPA1 MAPKAPK5 RPA2 RAD50 RPA3 MAP2K6 RAD17 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection CD3G RAC1 IL6 VAV1 MAPK8 IGHV3-23 IGLV IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 ADAM17 IGHV4-59 IGHV1-69 IGLV2-11 NFKB2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 HMOX1 C3 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 CYBA V1-7 V5-1 CDC42 V1-5 NOXO1 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 IGLV3-27 ELMO2 IGKC IGLV3-21 DOCK1 BAIAP2 CALM1 IGKV1-39 ABI2 IGKV1-33 V4-6 NOXA1 ABI1 IGHV3-53 JUN V4-2 PRKACG NOX1 IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK ELMO1 GNGT1 GNGT2 ACTB CYFIP2 WIPF1 WNT5A WIPF2 WIPF3 GNAT3 C3AR1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK MEFV PRKAR2B PLCG2 MYO5A ARPC1B ARPC1A VAV3 WASL CTSG PTK2 SYK GNAI3 ADCY4 WAS ADCY3 VAV2 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 NT5E GNG5 PYCARD GNG4 IGHG3 GNG7 IGHG4 GNG8 IGHG1 HSP90AB1 CYSLTR1 IL10 IGHG2 CYSLTR2 CD163 PLK2 GGT1 DPEP2 RHBDF2 DPEP1 MYH9 MYO9B ACTG1 GNAZ NCKIPSD DVL1 DVL2 DVL3 NLRP3 GGT5 FZD7 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 NCK1 FCGR3A ACTR3 ACTR2 FGR MYH2 GNG12 ADORA2B GNG11 FCGR1A GNG13 WASF3 MYO10 GNB2 P2RX7 P2RX4 TXNIP GNB1 FCGR2A GNAS MYO1C GNB4 SUGT1 GNB3 GNB5 FURIN ABL1 CASP1 IL18 IL1A IL1B GSDMD RELA NFKB1 AHCYL1 PRKACA ITPR1 ITPR2 ITPR3 PRKAR1A LYN YES1 TXN INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity TNKS2 WWP2 RNF146 PSMA5 FRK PSMA6 OTUD3 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEDD4 PTEN AKT2 AKT3 AKT1 CSNK2A1 CSNK2A2 CSNK2B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 PREX2 TRIM27 MKRN1 USP13 TNKS ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells CHRNA9 KCNMB1 KCNMA1 CHRNA10 KCNN2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) MSH6 MSH2 PMS2 MLH1 PCNA LIG1 POLD3 POLD4 EXO1 POLD1 POLD2 RPA1 RPA2 RPA3 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC5 GNE NPL NEU2 NEU3 NEU4 ST6GALNAC3 SLC17A5 ST6GALNAC4 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA SLC35A1 ST8SIA1 ST8SIA2 ST3GAL6 GLB1 ST8SIA3 ST6GALNAC6 ST6GALNAC2 ST6GALNAC1 CMAS NANP NANS ST3GAL4 ST6GAL2 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling STAT3 HDAC3 EP300 CD274 PRDM1 HDAC1 SIN3A IL2RG HDAC2 HIF1A DNMT1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol PLCG2 CALM1 INPPL1 PLD4 INPP5B PLCB3 PLCZ1 PLCB1 INPP5D PLCB2 INPP5J PLCE1 ITPK1 ITPKB ITPKC PLCB4 PTEN SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 OCRL PLCG1 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism PM20D1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT PLK1 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 NEK9 SPC25 NEK6 NEK7 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 EML4 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 HVCN1 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ADAM2 ACR KCNU1 CATSPERB CATSPERD CATSPERG CD9 ZP1 ZP3 ZP2 ZP4 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission PRKAG1 PRKAG2 PRKAG3 RAC1 MDM2 SRC NRAS MAPK1 GRIN2B HRAS MAPK3 GRIP1 RPS6KA6 NSF PRKCG CASK KPNA2 GABRG3 GABRG2 GRIP2 GRIA1 LIN7A LIN7C LIN7B EPB41L1 TSPAN7 GRIA3 CHRNA1 GRIA4 CHRNB2 GRIN3B CHRNB4 GNAL CHRNA3 GRIN3A CHRNB3 NBEA CHRNA2 GABRB3 CHRNA5 GABRB2 CHRNA4 GABRB1 CHRNA7 RASGRF2 CHRNA6 RASGRF1 CHRNA9 KIF17 NRGN CHRND GABRR3 CHRNG DLG1 GABRR2 CHRNE DLG3 GABRR1 DLG4 NPTN GRIK5 HTR3E GRIK3 HTR3C GRIK4 HTR3D GRIK1 HTR3A GRIK2 NRG1 HTR3B NCALD ARHGEF9 PICK1 CAMKK1 CAMKK2 GLRA1 PDPK1 GLRA2 CACNG8 GLRA3 CACNG2 CACNG3 KCNJ2 CACNG4 KCNJ3 GABRA2 GIT1 GABRQ KCNJ4 GABRA1 PRKAA1 GABBR2 PRKAA2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GABRA6 GABRA5 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GLRB APBA1 PRKCB CALM1 AP2A1 PRKACG PRKACB RPS6KA1 GRIA2 GNGT1 GNGT2 GNAT3 ADCY9 PRKAR1B PRKAR2B PRKACA GNAI3 ADCY4 PRKCA PLCB3 ADCY3 PLCB1 PRKX PLCB2 ADCY2 CAMK2B ADCY1 ACTN2 CAMK2D ADCY8 GNG10 GRIN2C CAMK2A ADCY7 PRKAR2A PPM1E ADCY6 GNG3 GNAI1 PPM1F GRIN2D ADCY5 GNG2 GNAI2 GRIN1 GRIN2A GNG5 DLG2 GNG4 LRRC7 GNG7 PRKAR1A GNG8 CAMK4 NEFL CAMK1 PRKAB2 AKAP5 CAMK2G PRKAB1 MYO6 RPS6KA3 RPS6KA2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development NEUROD1 NKX6-1 IAPP NKX2-2 INS PDX1 PAX4 PAX6 HNF1B HNF1A MAFA RFX6 MAML2 INSM1 MAML1 PTF1A FOXA3 NEUROG3 GCK FOXA2 KAT2B KAT2A MAMLD1 SLC2A2 AKT2 AKT3 AKT1 HES1 NOTCH1 EP300 RBPJ FOXO1 CREBBP FGF10 SNW1 HNF4G ONECUT3 ONECUT1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes IRAK1 UBA52 NGFR SQSTM1 PRKCI RIPK2 MYD88 IKBKB UBB TRAF6 UBC NGF RPS27A ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade PDE6B SLC24A1 PDE6A PDE6G RHO SAG CNGA1 GNAT1 CNGB1 GNB1 GNGT1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 FOS ATF1 UBB ECSIT NKIRAS1 NKIRAS2 UBC IKBIP MEF2A RPS27A DUSP4 DUSP3 NFKB1 IRAK4 VRK3 MAPK9 NFKBIA DUSP6 MAPK8 DUSP7 MAPK7 TLR10 TLR5 LRRC14 ELK1 USP14 NLRX1 PELI3 PELI2 NFKBIB NLRC5 MAPK10 NOD1 NOD2 AGER USP18 IRAK2 MAPK1 S100A12 N4BP1 MAP3K1 MAPK3 S100B TNIP2 MAP2K1 SAA1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 TP53 ATF2 NFKB2 HMGB1 RPS6KA5 CASP8 UBE2N TIFA TAB3 ALPK1 TAB2 TAB1 IRAK1 PPP2R5D MEF2C TRAF2 RPS6KA3 PELI1 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SREBF1 NRIP1 EP300 TBL1X PPARA PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 NR1D1 HDAC3 NCOR1 TBL1XR1 SMARCD3 RORA CARM1 RORC CHD9 CPT1A HELZ2 RXRA TGS1 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT KIT DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2AC6 H2AC7 EZH2 H2AX DNMT3B GSDME DNMT3A PRIM2 DNMT1 PRIM1 POLA1 H3-3B POLA2 H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 RBBP4 RBBP7 H2AB1 H2AZ2 H2AC20 H2AC8 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions ITGA2B CALM1 FN1 PAPSS1 BCL2L11 ATG7 SRC YWHAB MARK3 NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 TENT4A KIAA1549 MPRIP BRAF TRIM24 AGTRAP AP3B1 SND1 ESRP1 AKAP9 KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 LMNA AGK QKI CLCN6 FAM131B AGGF1 CAMK2B CAMK2D CAMK2A CAMK2G ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 CSK VCL ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium CEP83 DYNLRB2 DYNLRB1 IFT25 CEP89 CEP57 ARF4 C2CD3 CETN2 PLK1 CEP164 PKD2 PKD1 IFT52 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CNGA2 CDK1 BBS9 CNGA4 BBS7 TNPO1 IFT57 CEP290 NINL IFT56 BBS5 CC2D2A BBS4 RAB8A OFD1 DYNLT5 IQCB1 MKKS EXOC8 DYNLT2 IFT140 EXOC7 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 RP2 BBS12 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 EXOC5 NEK2 IFT46 SFI1 EXOC2 SDCCAG8 EXOC1 IFT70B PPP2R1A IFT70A DCTN2 SSNA1 DCTN3 DYNLT2B ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 CEP152 WDR19 GBF1 CSNK1E KIF17 SCLT1 RAB11A ATAT1 NEDD1 TTC8 ALMS1 TRIP11 CEP162 B9D1 CEP41 CEP43 CLUAP1 YWHAG ARL13B INPP5E PDE6D DYNLL1 HSP90AA1 CKAP5 DYNLL2 HDAC6 MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 YWHAE DYNC1H1 NDE1 RHO B9D2 CNGB1 CPAP SMO AKAP9 PRKAR2B TUBA4A PRKACA DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CCP110 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CEP131 CSNK1D IFT80 CYS1 TUBA1A RPGRIP1L LZTFL1 CCT3 IFT88 CCT2 IFT81 UNC119B ARL6 ARL3 FBF1 MCHR1 TCP1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B CEP70 NPHP1 CEP72 NPHP3 CEP192 NPHP4 KIF3C MARK4 CEP76 RAB11FIP3 CCT8 CEP78 PLK4 CCT5 BBS2 CCT4 BBS1 ODF2 RAB3IP TUBB4B IFT122 TUBB4A BBIP1 IFT20 AHI1 IFT22 MKS1 IFT27 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR2K POLR2L TBP GTF3C1 GTF3C2 GTF3C3 CRCP GTF3C4 GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation CBFB GLI2 IHH HDAC4 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network COG7 COG6 COG5 COG4 COG3 COG2 COG1 NAA35 VAMP3 NAA38 VAMP4 NAPA NAPB TMF1 STX16 RHOBTB3 ARL1 NAPG STX10 TGOLN2 ARFRP1 VPS51 VPS53 VPS52 VTI1A STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B PLIN3 NSF M6PR USP6NL SCOC SYS1 GCC2 GCC1 RABEPK RAB43 GOLGA4 GOLGA1 ARFIP2 NAA30 COG8 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins NUDT16 ADPRM NUDT5 NUDT15 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol ADAT2 TRMT9B QTRT1 GON7 DUS2 CTU2 TP53RK QTRT2 CTU1 TRMT5 TRMT6 TRMT13 TRMT11 TRMT61A TRMT112 QNG1 URM1 WDR4 THADA LAGE3 OSGEP THG1L ALKBH8 TYW1 LCMT2 TRMT44 TRDMT1 PUS3 TRMT10A TYW5 METTL1 NSUN2 EPRS1 TYW3 TYW2 TPRKB ADAT1 TRMT1 CDKAL1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling GP5 VWF GP1BA YWHAZ RAF1 PIK3R1 GP9 GP1BB FLNA MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease DDX6 LSM1 LSM5 LSM4 LSM3 PATL1 EDC3 LSM2 EDC4 LSM7 LSM6 XRN1 DCP1A DCP2 DCP1B CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARF4 PKD2 PKD1 CNGA2 RHO BBS9 CNGA4 BBS7 CNGB1 BBS5 BBS4 RAB8A MKKS EXOC8 EXOC7 SSTR3 BBS10 RP2 BBS12 EXOC4 EXOC3 EXOC6 EXOC5 SMO EXOC2 EXOC1 ASAP1 GBF1 RAB11A ATAT1 TTC8 CYS1 CCT3 LZTFL1 CCT2 UNC119B ARL6 ARL3 ARL13B TCP1 MCHR1 INPP5E PDE6D NPHP3 HDAC6 CCT8 RAB11FIP3 CCT5 CCT4 BBS2 BBS1 RAB3IP BBIP1 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 CDC20 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 FBXO5 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B PIM1 NOX4 GAB2 GRB2 CDKN1A FLT3 BCL2L1 PTPN11 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C19 CYP2C9 CYP2U1 CYP4F2 CYP4A11 CYP2C8 CYP1B1 CYP1A2 CYP1A1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression GATA3 H2AX H3-3B H3C8 FOS H2AJ H3C15 TGFA CCND1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 FOSB BCL2 H2AB1 KPNA2 SMC3 H2AC8 H2AC6 H2AC7 GPAM ATF2 SP1 RAD21 STAG1 H2BC26 H2BC21 STAG2 NRIP1 EP300 H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 CREBBP SMC1A H2BC11 HSP90AA1 CARM1 YY1 H2AZ2 TNRC6C TNRC6A TNRC6B CCNT1 JUN MYB CBFB TBP RUNX1 GTF2A1 GTF2A2 CITED1 PRMT1 CDK9 HDAC1 KCTD6 ESR1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J PGR POLR2K POLR2L GTF2F1 KAT5 GTF2F2 AXIN1 KAT2B H2AC19 H2AC14 H2BC12L MYC HSP90AB1 CXCL12 FOXA1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD NCOA3 H4C9 NR5A2 TFF3 JUND TFF1 KANK1 CXXC5 MOV10 KDM4B AGO3 PTGES3 AGO4 USF2 H2AC20 USF1 AGO1 ZNF217 AGO2 EBAG9 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions ITGA2B ALCAM SCN11A DPYSL2 LAMA1 SCN9A NRCAM EPHB2 SCN1B SCN1A ANK2 ANK3 LAMB1 ANK1 LAMC1 SHTN1 SCN10A SCN8A RAC1 KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 SPTA1 NCAN SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN L1CAM KIF4B KIF4A ITGA10 CNTN1 CNTN2 CD24 SCN2A SCN2B PAK1 NRP2 CNTNAP1 SH3GL2 CHL1 SCN5A SPTAN1 LYPLA2 SPTB DNM1 DNM3 GAP43 DCX NUMB SCN4A SCN4B MAPK1 ITGA9 SCN7A NCAM1 MAPK3 RANBP9 MAP2K1 NFASC MAP2K2 RPS6KA6 HSPA8 DNM2 EGFR DLG1 DLG3 DLG4 RPS6KA5 ITGB1 CLTC CLTA ITGA2 ITGA1 SDCBP AP2A1 AP2A2 AP2M1 RPS6KA1 AP2S1 AP2B1 ITGAV VAV2 NRP1 CSNK2A1 CSNK2A2 CSNK2B ITGB3 ITGA5 RPS6KA3 RPS6KA2 RPS6KA4 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SNRPD3 NCBP1 SNRPG NCBP2 LSM10 SNRPE SLBP ZNF473 LSM11 SNRPF SNRPB PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation H2AX TNRC6A TNRC6B JUN MAML2 MAML1 PRKCI H3-3B H3C8 RUNX1 H2AJ NOTCH1 NOTCH2 H3C15 NOTCH3 NOTCH4 CCND1 H2BC9 E2F1 H2BC8 H2BC5 E2F3 H2BC3 H2BC1 TFDP1 SNW1 TFDP2 SIRT6 H2AB1 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB H2AC8 H2AC6 H2AC7 TP53 KAT2B KAT2A MAMLD1 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 EP300 H2BC17 H2BC12 RBPJ H2BC13 H2BC14 H2BC15 CREBBP H2BC11 H4C9 MOV10 AGO3 H2AZ2 AGO4 H2AC20 AGO1 AGO2 ELANE TNRC6C DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 FGF9 FLRT1 FGF20 FGF23 FGF22 SOS1 PIK3R1 PIK3CA FGF10 NRAS GAB1 FRS3 FLRT3 HRAS PLCG1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FLRT2 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants FLT3 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB HADHA ACADL REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation MEAF6 BRPF1 ING5 MTA2 BRPF3 ING2 PIP4P1 TP53 BRD1 PIN1 PIP4K2A PIP4K2B KAT6A AKT2 AKT3 MBD3 AKT1 BRD7 EP300 GATAD2B GATAD2A HDAC1 HDAC2 CHD4 RBBP4 CHD3 RBBP7 MAP2K6 PML SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM POLR2I POLR2J POLR2K POLR2L FGFR2 GTF2F1 GTF2F2 NCBP1 NCBP2 POLR2A POLR2B FGF1 POLR2C FGF2 POLR2D POLR2E POLR2F POLR2G POLR2H TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses PRKAG1 PRKAG2 PRKAG3 RAC1 MDM2 SRC NRAS MAPK1 GRIN2B HRAS MAPK3 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE PDPK1 GIT1 PRKAA1 PRKAA2 CALM1 AP2A1 PRKACG PRKACB GLS SLC1A1 SLC1A2 RPS6KA1 SLC1A3 SLC6A3 SLC1A6 SLC5A7 SLC1A7 SLC38A2 SLC38A1 SLC6A12 GNGT1 GNGT2 GNAT3 ADCY9 PRKAR1B PRKAR2B GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ACTN2 ADCY8 GNG10 GRIN2C ADCY7 PRKAR2A ADCY6 PPM1E GNG3 GNAI1 PPM1F GRIN2D ADCY5 GNG2 GNAI2 GRIN1 GRIN2A GNG5 DLG2 GNG4 LRRC7 GNG7 CAMK4 GNG8 NEFL CAMK1 AKAP5 MYO6 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GAD1 GAD2 SNAP25 SYT1 VAMP2 STX1A GRIP1 RPS6KA6 NSF PRKCG CASK GABRG3 KPNA2 HSPA8 GABRG2 GRIP2 GRIA1 LIN7A LIN7C LIN7B ABAT EPB41L1 ARL6IP5 TSPAN7 GLUL GRIA3 UNC13B GRIA4 CACNA2D1 GRIN3B SLC6A13 GNAL CACNA2D3 GRIN3A CACNA2D2 NBEA SLC6A11 GABRB3 SLC22A2 GABRB2 COMT SLC22A1 GABRB1 ACHE RASGRF2 SLC6A1 RASGRF1 KIF17 SLC6A4 SLC18A2 NRGN GABRR3 SLC18A3 GABRR2 SLC32A1 DLG1 GABRR1 SYN3 DLG3 SYN2 DLG4 NPTN GRIK5 SYN1 HTR3E GRIK3 ALDH5A1 HTR3C GRIK4 SLC17A7 HTR3D GRIK1 BCHE HTR3A GRIK2 RAB3A NRG1 RIMS1 HTR3B NCALD ARHGEF9 PPFIA1 PICK1 PPFIA4 CAMKK1 PPFIA3 CAMKK2 PPFIA2 GLRA1 CACNB1 GLRA2 CACNB2 CACNB3 CACNG8 GLRA3 CACNB4 NAAA CACNG2 TOMT CACNG3 CHAT KCNJ2 CACNA1B CACNG4 CACNA1A KCNJ3 GABRA2 CACNA1E GABRQ CPLX1 DNAJC5 KCNJ4 GABRA1 GLS2 TSPOAP1 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GABRA6 GABRA5 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GLRB APBA1 PRKCB GRIA2 ALDH2 PRKACA PRKCA PLCB3 PLCB1 PLCB2 CAMK2B CAMK2D CAMK2A MAOA PRKAR1A PRKAB2 CAMK2G PRKAB1 RPS6KA3 RPS6KA2 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) TFPT MCRS1 INO80 COPS3 COPS6 ERCC4 ERCC1 ERCC5 CETN2 COPS8 LIG1 UBA52 RNF111 UBB UBC RPS27A RBX1 PIAS3 UBE2I ACTB XRCC1 LIG3 CUL4A CCNH DDB1 ACTL6A PIAS1 CUL4B DDB2 SUMO1 SUMO3 SUMO2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 COPS5 MNAT1 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 UBE2V2 GPS1 UBE2N PCNA POLD3 POLD4 COPS4 RUVBL1 POLD1 COPS2 NFRKB POLD2 PARP1 PARP2 ACTR5 USP45 RAD23A CHD1L ACTR8 RPA1 YY1 RAD23B RPA2 INO80C INO80B POLE4 INO80E INO80D XPA RPA3 COPS7B POLE2 COPS7A POLE3 XPC BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism HMGCS2 HMGCLL1 AACS ACAT1 HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis OCA2 SLC45A2 DCT TYRP1 TYR DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication MCM6 MCM2 H2AX ANAPC15 ANAPC16 KPNA1 ANAPC7 UBE2C LIG1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 H3-3B CDC16 ANAPC4 ORC5 H3C8 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 H2AJ ORC3 CCNA2 ORC2 CCNA1 H3C15 FZR1 H2BC9 H2BC8 H2BC5 SKP2 H2BC3 H2BC1 CCNE2 CCNE1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 CDC6 KPNB1 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 KPNA6 PSMB3 POLRMT UBC POLG2 PSMB1 RNASEH1 RPS27A CDT1 ADRM1 FEN1 SEM1 MCM10 POLG RBX1 TWNK PSMC5 DBF4 PSMC6 MGME1 PSMC3 EXOG PSMC4 PSMC1 RPA4 PSMC2 SSBP1 CDC7 POLE H2AC19 H2AC14 RFC5 H2BC12L RFC3 RFC4 RFC1 RFC2 TOP3A DNA2 PCNA POLD3 POLD4 POLD1 POLD2 H4C9 RPA1 GINS1 RPA2 GINS2 CDC45 POLE4 MCM7 GINS3 H2AC20 GINS4 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS2 EIF2S3 EIF2S2 EIF2S1 FAU EIF4EBP1 EIF4E EIF4B RPS27A EIF4G1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 PABPC1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 GYG2 GYS2 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling FGF9 FGF20 FGF23 FGF22 SOS1 FGF10 NRAS FRS3 HRAS FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) RAD1 ATM RAD9B ATR H2AX RAD9A LIG1 CCNA2 CCNA1 RNF4 H2BC9 H3-4 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CDK2 SIRT6 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ERCC4 HERC2 ERCC1 UBA52 UBB UBC RPS27A SEM1 PIAS4 UBE2I PPP4R2 TIPIN TIMELESS BRCC3 PPP4C CLSPN TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 MUS81 RNF8 MRE11 NSD2 BRCA1 RAD52 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE POLH GEN1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 UBE2V2 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 MDC1 RHNO1 BLM RTEL1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 H4C9 XRCC2 XRCC3 RPA1 RPA2 PALB2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 PPARA ATF2 CRTC2 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 NPAS2 HELZ2 RAI1 TGS1 NRIP1 EP300 TBL1X MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 NR1D1 SIRT1 NCOR1 TBL1XR1 RORA CARM1 RORC RORB BMAL1 CLOCK RXRA PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PLA2G4A PLCB3 PRKX PLCB1 ADCY2 PLCB2 CAMK2B ADCY1 CAMK2D ADCY8 GNAQ CAMK2A ADCY7 ADCY6 PRKAR2A ITPR1 ADCY5 PLCB4 ITPR2 ITPR3 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 GNA14 GNA15 GNA11 MAPK1 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AC6 H2AC7 RPS2 PBRM1 H2AX SMARCB1 DNMT3A H2AC17 H2AC12 PRMT7 PRMT5 PRMT3 ARID1A H2AC1 ARID1B WDR77 COPRS SMARCD3 H2AC19 SMARCC1 H2AC25 H2AC14 H3C8 SMARCC2 H2AC21 H2AJ ARID2 PRMT6 WDR5 PRMT1 H3C15 SMARCD1 SMARCD2 CCND1 JAK2 SMARCA2 SMARCA4 H4C9 CARM1 ACTL6B CDK4 RBBP7 ACTL6A H2AB1 SMARCE1 H2AZ2 H2AC20 H2AC8 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib HSP90AA1 CDC37 ERBIN ERBB2 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD4 SMAD3 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR UNC93B1 TLR8 TLR9 TLR7 TLR3 CTSV CTSS LGMN CTSL CTSB CTSK HSP90B1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 C3 C4A IGKV3-20 IGHV4-34 C4B_2 IGHV1-2 CFB IGHV1-46 C2 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHG3 IGHG4 IGHG1 IGHG2 FCN1 FCN2 FCN3 MASP1 CFD MBL2 CRP C1QB C1QA COLEC11 COLEC10 C1S C1R GZMM C1QC INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade INS SOS1 THEM4 KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 SHC1 GRB10 INSR NRAS GAB1 MAPK1 HRAS MAPK3 FRS2 FLT3 PTPN11 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib HSP90AA1 CDC37 ERBIN ERBB2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA CHUK TRIM21 UBA52 MYD88 RELA TICAM1 UBB NKIRAS1 NKIRAS2 UBC RPS27A NFKB1 NFKBIA CTNNB1 NFKBIB POLR2E POLR2F POLR2H TRIM32 ZBP1 POLR2K TBK1 POLR2L IRF3 NLRP4 MRE11 DTX4 NFKB2 TLR3 CRCP EP300 POLR3GL POLR3A POLR3B RIPK3 POLR3C CREBBP POLR3D POLR1C POLR3E POLR3F CGAS POLR1D DDX41 POLR3G LRRFIP1 POLR3H AIM2 IRF7 POLR3K TRIM56 PRKDC IKBKB DHX9 NLRC3 IFI16 DHX36 STAT6 XRCC6 IKBKG RIPK1 XRCC5 TREX1 STING1 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification PDCD1 PSMA5 PRKAG1 PSMA6 PRKAG2 PSMA3 PSMA4 PSMA1 MAGT1 PSMA2 CUL3 UBA52 PRKAG3 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 JAK1 PSMA7 PSMB6 PSMB7 PSMB4 PDCD1LG2 PSMB5 UBB PSMB2 B3GNT3 PSMB3 UBC PSMB1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 RBX1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 SPOP PSMC1 PSMC2 CCND1 MIB2 CDK4 TUSC3 NEK2 TMEM258 CD274 VCP SEL1L OST4 COPS5 OSTC STT3A STT3B RNF185 GSK3B PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 YWHAG CSNK2B RPN2 DDOST RPN1 DAD1 PRKAA1 PRKAA2 RNF5 ERLEC1 PSMD8 PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 BTRC SKP1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport SERPINA1 PPP6C TFG PPP6R1 PPP6R3 TMED2 CTSC TRAPPC2L LMAN1L F5 F8 NAPA TRAPPC6A NAPB TBC1D20 TRAPPC6B GORASP1 PREB LMAN1 GOLGA2 SEC22B NAPG STX5 SEC22A YKT6 SEC22C RAB1A TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 CNIH3 FOLR1 BET1 CTSZ AREG SEC23A NSF SAR1B GRIA1 SEC24B SEC24A SEC24D SEC24C CSNK1D SEC13 COL7A1 MCFD2 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants FLT3 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors H2AX MTA2 H3-3B H3C8 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 CHD5 H2BC3 IKZF1 IKZF2 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 ZNF532 H2AC8 H2AC6 H2AC7 G6PC1 H2AC19 H2AC14 H2BC12L NR2C2 MBD3 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 FBP1 H2BC15 HDAC2 H2BC11 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS CYP19A1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis DGKE DAGLA DGKD DGKB DGKA ABHD6 PRKCQ ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB PRKCD DGKK RASGRP2 DGKI DGKH ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 RASGRP1 MGLL DGKG LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CALM1 PRKACA CAMK4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling SPRED2 SPRED1 FGF23 FGF22 FGF18 FGF2 FGF10 FGF3 FGF4 FGFRL1 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle ARHGAP26 ARHGEF5 VAMP3 ARHGAP39 ARHGAP21 TFRC MCF2 MCAM ERBIN VANGL1 ARHGAP32 DIAPH3 TJP2 CAV1 VAV2 RTKN SOWAHC ARHGEF10L STK10 AKAP13 ROCK1 SLK ROCK2 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 STARD8 MYO9B RHOB SNAP23 FLOT1 CIT DAAM1 ARHGEF3 FLOT2 ARHGEF1 ARHGEF2 PKN3 PIK3R2 ARHGEF25 PIK3R1 ARHGEF28 ARHGAP1 IQGAP3 ARHGDIG STOM ARHGAP5 RHPN2 ARHGAP35 ECT2 PREX1 STARD13 OPHN1 JUP CAVIN1 BCR PCDH7 MCF2L MYO9A NET1 ANLN DIAPH1 ABR ACTC1 RACGAP1 DLC1 PKN2 PKN1 DEPDC1B ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 PAK5 PAK1 SOS1 PAK3 PAK2 NCK2 RAC1 NCK1 SLIT2 SOS2 PAK4 ROBO1 PAK6 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 RHOC ARHGEF5 TIAM2 OBSCN ARHGEF4 ARHGEF7 ARHGEF26 NGEF ARHGEF6 FGD1 FGD2 KALRN GNA13 FGD3 FGD4 TBXA2R GNA12 ARHGEF33 ARHGEF35 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 PLXNB1 VAV1 GNGT1 GNGT2 TIAM1 BTK SOS1 VAV3 VAV2 RASGRF2 GNG10 GNG3 ARHGEF18 GNG2 GNG5 GNG4 RHOA GNG7 ARHGEF10L GNG8 AKAP13 ROCK1 ROCK2 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 RHOB ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 ECT2 PREX1 SOS2 GNG12 MCF2L GNG11 GNG13 NET1 GNB2 ABR ARHGEF16 GNB1 GNB4 ADRA1D GNB3 ADRA1B GNB5 ADRA1A ARHGEF40 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids ACOT8 EHHADH HSD17B4 ACAA1 DECR2 ABCD1 SLC27A2 ACOT4 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease ETV6 FIP1L1 BIN2 KDR SOS1 PIK3R2 PIK3R1 PIK3CA STAT1 NRAS STAT3 WDR48 HRAS PDGFRA KANK1 PIK3CB GOLGA4 STRN S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase MCM6 MCM2 ANAPC15 ANAPC16 ANAPC7 UBE2C LIG1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ORC5 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 RB1 CDKN1A CDKN1B FZR1 CCND1 E2F1 SKP2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 SMC3 CDC6 CDCA5 PDS5B PDS5A RAD21 GSK3B WAPL STAG1 STAG2 SMC1A PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 CDC25B PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 FEN1 SEM1 RBX1 MAX PSMC5 PSMC6 ESCO1 PSMC3 ESCO2 PSMC4 PTK6 PSMC1 LIN54 PSMC2 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 CCNH CDK7 MNAT1 POLE RBL2 RFC5 RFC3 AKT2 MYC RFC4 AKT3 RFC1 AKT1 RFC2 DNA2 PCNA POLD3 POLD4 POLD1 POLD2 E2F4 E2F5 RPA1 GINS1 RPA2 GINS2 CDC45 POLE4 MCM7 GINS3 GINS4 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRA2C ADRB3 ADRA2B ADRA2A CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P HRH1 HTR6 ADRA1D HTR7 ADRA1B HRH3 ADRA1A HRH2 HRH4 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair RAD1 ATM RAD9B ATR H2AX RAD9A LIG1 CCNA2 CCNA1 RNF4 MAPK8 H2BC9 H3-4 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CDK2 SIRT6 KPNA2 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PARP1 PARP2 ERCC4 HERC2 ERCC1 UBA52 CHEK2 UBB UBC RPS27A FEN1 SEM1 PIAS4 UBE2I XRCC1 LIG3 PPP4R2 TIPIN TIMELESS BRCC3 PPP4C CLSPN SUMO1 TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 MUS81 RNF8 MRE11 NSD2 BRCA1 RAD52 BRCA2 EME1 KAT5 TP53 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE DCLRE1C POLH RIF1 GEN1 LIG4 RFC5 H2BC12L PAXIP1 RFC3 NHEJ1 RMI2 XRCC4 RFC4 SMARCA5 RFC1 SLX1B PPP5C TDP2 RFC2 TDP1 RMI1 UBE2V2 BAP1 TOP3A HUS1 UBXN1 POLL SPIDR BAZ1B RAD51B RAD51D APBB1 RAD51C KDM4A DNA2 POLQ MDC1 RHNO1 EYA1 BLM EYA2 RTEL1 POLM PCNA EYA3 RAD51AP1 EYA4 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 H4C9 XRCC2 PRKDC XRCC3 RPA1 RPA2 PALB2 KDM4B POLE4 RAD50 XRCC6 RAD51 XRCC5 RPA3 POLE2 POLE3 RAD17 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function TNRC6A TNRC6B SP1 ZEB2 ANGPTL4 CTNND1 HEYL CTNNB1 PRDM8 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 JUP ADAM19 ILF3 CDH11 SNAI1 MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis NEU1 CTSA GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 MAML2 MAML1 NEURL1 YBX1 EGFR KAT2B KAT2A MAMLD1 UBB PSENEN PSEN2 PSEN1 UBC APH1A HES1 NCSTN RPS27A APH1B HES5 HEYL NOTCH1 EP300 NOTCH3 RBPJ CREBBP HEY1 STAT1 HEY2 MIB2 SNW1 PLXND1 WWC1 FABP7 DLGAP5 EGF PTCRA PBX1 TACC3 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS SAP30 BRMS1 IFNAR1 FURIN PHF21A CD79B CD79A SUDS3 RCOR1 CUL3 IGHM BLNK HMG20B JAK3 IFNGR1 IFNGR2 SIGMAR1 TYK2 JAK1 IGHD SAP30L S1PR1 SAP18 CRBN STAT2 VAV1 SH3KBP1 ACE2 TUBB BRD4 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 ZBP1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 SOS1 IGKV2D-30 IGHV4-59 IGHV1-69 COMT IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 MBD3 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 GATAD2B GATAD2A IGKV3-20 ITGB1 IGHV4-34 IGHV1-2 IGHV1-46 TLR9 IGHV4-39 IGHV IGKV2-29 HDAC2 IGKV2-28 IGLC3 IGLC1 IGLC2 HSP90AA1 CHD4 RBBP4 CHD3 IGKV3D-20 IL6R NFE2L2 RBBP7 IGLV3-19 IGKV2-30 RIPK1 IGHV2-70 IGHV2-5 KEAP1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PDCD1 IGLV3-21 FKBP1A AP2A1 IGKV1-39 MTA2 IGKV1-33 AP2A2 IGHV3-53 REST IGLC7 IGKV5-2 IGKV1-5 AP2M1 IGLC6 RBX1 AP2S1 MTA1 HDAC1 MTA3 AP2B1 NR3C1 BTK PLCG2 ATP1B3 ATP1B2 SYK ATP1B1 IMPDH1 IMPDH2 ATP1A4 ATP1A3 ATP1A2 TLR7 ATP1A1 HSP90AB1 CYSLTR1 ROCK1 ROCK2 ITGA4 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 KDM1A FXYD6 JAK2 FKBP4 NCK1 PTGES3 ARID4A ARID4B FNTA FNTB IL1R1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs CSTF1 FIP1L1 PAPOLA SYMPK CPSF7 NCBP1 NCBP2 CPSF1 CPSF4 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PABPN1 PCF11 CLP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea KCNMB1 KCNMA1 CHRNA10 KCNN2 EZR SPTBN1 RDX MSN CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 SPTAN1 PLS1 TPRN TMC1 MYO7A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 USH1C ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 CASK GRXCR2 GSN WHRN LHFPL5 OTOGL TMIE USH1G STRC EPB41L1 MYO15A SLC26A5 CHRNA9 TWF1 MYH9 MYO1C DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS SFTPC IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR TGFA EGF EREG BTC AREG EPGN HBEGF EGFR POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription SP1 ARID1A TFAP2A RB1 KLF9 ZEB2 FOXJ2 STRAP FOXP2 KLF4 FOXA2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF9 FGF20 FGF23 FGF1 FGF2 FGFR1 FGF4 FGF6 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A5 SLC12A1 SLC12A6 SLC12A7 SLC12A2 SLC12A3 SLC12A4 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) PRELP ACAN KERA OGN OMD FMOD LUM B4GALT1 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 HSPA1A PSMD13 PSMA7 HSPB1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PABPC1 PSMB1 RPS27A ADRM1 SEM1 EIF4G1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 HSPA8 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors MASP1 CALR APOB COLEC11 FTL COL3A1 COL4A2 APOA1 COL4A1 APOE COLEC12 MSR1 COL1A1 SCARA5 COL1A2 MARCO SCGB3A2 FTH1 HSP90B1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol GSK3A CHUK CDKN1A CDKN1B TSC2 MDM2 AKT1S1 AKT2 GSK3B AKT3 BAD CASP9 AKT1 MKRN1 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids ACSM5 ACSM4 GLYAT ACSM1 GLYATL3 ACSM2B GLYATL2 GLYATL1 ACSM2A RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle CDC42EP1 GIT2 WWP2 ARHGAP26 RAB7A VAMP3 ARHGEF7 ARHGAP21 PAK4 TFRC SLC1A5 MPP7 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 PAK1 PAK3 PAK2 STEAP3 GJA1 WIPF2 CAV1 WASL WAS ARL13B CPNE8 DOCK8 SNAP23 FNBP1L FNBP1 SCRIB SYDE1 NIPSNAP2 RHOJ PIK3R2 TRIO PIK3R1 CDC42BPB CDC42BPA ARHGAP1 GIT1 IQGAP3 SLC4A7 STOM FMNL3 ARHGAP5 ARHGAP35 PREX1 OPHN1 OCRL JUP CDC42 TMPO DEPDC1B SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 HPN SPINT2 MST1R SPINT1 MST1 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions JUP CTNNB1 CDH11 CDH8 CTNND1 CTNNA1 CDH24 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism GOT2 FMO1 SUOX BHMT MTAP TST ADI1 CTH MTRR ETHE1 AHCY SLC25A10 CDO1 MTR MAT1A GADL1 APIP MRI1 CSAD ADO TXN2 CBS ENOPH1 MPST GOT1 TSTD1 BHMT2 SQOR PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU PELO ABCE1 RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins UBA52 UBE2E1 UBE2D1 CDC73 RNF152 SHPRH HLA-B RRAGA BCL10 PEX2 HLA-A RNF40 RNF144A SKIC8 SELENOS WAC UBE2J2 CTR9 RTF1 UBB TMEM129 HLTF UBC LEO1 PEX10 RPS27A PEX12 PEX13 DERL1 PEX14 PAF1 RNF181 H2BC9 UBE2D2 H2BC8 H2BC5 H2BC3 H2BC1 UBE2B RAD18 VCP UBE2V2 UBE2L3 UBE2N H2BC17 H2BC12 H2BC13 PCNA H2BC14 RNF20 H2BC15 H2BC11 UBE2D3 PRKDC UBE2A TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 PIK3R4 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PIK3C3 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA EEA1 DUSP6 TASL DUSP7 RBSN IRF5 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 SLC15A4 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry FURIN UBA1 AP2A1 AP2A2 GPC1 RPSA AP2M1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 CD14 ATG7 AGRN UBA7 UBA6 CD209 UBA5 SDC1 AP2S1 RNASEK HAVCR1 PROS1 CLDN1 MRC1 PIK3R1 EMC4 CD33 HSPA5 CD300A TIMD4 MERTK AP2B1 AXL TYRO3 MAPRE3 GAS6 LY6E UBA3 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) ALOX5 DPEP2 DPEP1 MAPKAPK2 CYP4F2 GGT5 CYP4A11 LTC4S ABCC1 ALOX15 CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 LTA4H PTGR1 ALOX5AP GGT1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery POLR2I POLR2J POLR2K POLR2L ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation PMEL BCL7A MLANA BCL7C DPF1 MYO5A BCL7B DPF2 DPF3 SMARCB1 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 ARID1A GPR143 ARID1B SMARCD3 SMARCC1 SMARCC2 DCT TYRP1 AKT2 TYR CTNNB1 SOX10 TFAP2A SMARCD1 SMARCD2 LEF1 SMARCA2 ACTB SMARCA4 ACTL6A SMARCE1 MAPK14 USF1 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 SGK2 STOML3 ATP10D ATP10B ATP10A ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TCIRG1 TPCN2 TPCN1 CLCN7 CLCN5 ATP6V1E1 CLCN4 ATP6V1E2 OSTM1 ATP6V0B ATP13A4 ATP6V1G1 ATP13A5 ATP6V0E1 ATP13A2 ATP6V1G2 UNC79 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 STOM CALM1 UBA52 UBB UBC RPS27A PDZD11 SGK1 NEDD4L RYR1 RYR2 ATP2A3 ATP2A2 ATP2A1 RYR3 SLN CLIC2 ATP1B3 ATP1B2 CLCN6 ATP1B1 TRDN ASPH ATP8A2 ATP8A1 CAMK2B ATP12A CAMK2D BEST2 CAMK2A SLC9C1 ATP1A4 BEST3 SLC9C2 ATP1A3 BEST1 BEST4 ATP1A2 ATP11C ATP11B ATP1A1 ATP11A SRI SLC9B1 PLN SLC9B2 SCNN1G CAMK2G SCNN1D SCNN1B SCNN1A ATP2B4 TTYH3 ATP2B3 TTYH2 ATP2B2 CLCNKB ATP2B1 WNK4 CLCNKA FXYD4 NALCN TRPM1 FXYD3 TRPM2 ASIC4 FXYD2 ASIC5 TRPM7 FXYD1 CLCA2 TRPM8 FKBP1B CLCA1 TRPM5 FXYD7 ASIC2 TRPM6 FXYD6 ASIC3 TRPM3 CLCA4 TRPM4 ASIC1 TRPC7 WWP1 ATP8B4 MCOLN3 ATP8B3 TRPC5 ATP8B2 TRPC6 ATP8B1 TRPC3 ATP4B TRPA1 ATP4A TRPC4 WNK1 TRPC1 TRPV2 WNK2 RAF1 TRPV3 WNK3 TRPV1 CUTC UNC80 MCOLN1 ATP7B MCOLN2 TRPC4AP ATP7A TRPV6 TSC22D3 TRPV4 ANO8 TRPV5 ANO9 ANO6 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors MITF SUMO2 FOXL2 HIC1 SP3 TFAP2B TFAP2C CDKN2A MTA1 TP53 PIAS4 PIAS3 MDM2 UBE2I PIAS1 SUMO1 SUMO3 TP53BP1 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 TFAP2A MYBL2 HSPD1 NPM1 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 APEH RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 HEMK2 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 TRMT112 RPL27 RPL26 GSPT2 RPL29 GSPT1 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 ETF1 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat POLR2I POLR2J POLR2K POLR2L CCNK GTF2H1 CCNT2 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions SHH HHIP BOC GAS1 PTCH1 CDON IHH DHH LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis PCNA POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RFC5 RFC3 RFC4 RFC1 RFC2 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA PLA2G4B PLA2G2A DDHD2 DDHD1 GNPAT LPCAT4 PLA2G10 GPD1 GPD1L PLA2R1 PLD1 PLA2G4A GPAM AGPAT5 PLA2G1B GPAT2 LPCAT1 PLA2G5 PLD6 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PLD2 LIPI GPAT4 ACP6 LIPH GPD2 GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 ALPI PLA2G4D MIGA1 ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion FURIN UBA52 TSG101 NMT2 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 UBB VPS28 UBC PPIA RPS27A ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility EREG BTC MEMO1 NRG2 HBEGF NRG3 EGFR NRG4 EGF DIAPH1 RHOA ERBB2 NRG1 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) SV2C SV2B SV2A VAMP1 VAMP2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity PRKAA2 ADIPOQ ADIPOR1 ADIPOR2 PRKAG2 STK11 PRKAB2 MLXIPL MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression MCM2 SMARCB1 LIG1 PLK1 CCNB1 SMARCC1 SMARCC2 ATP6V1E1 ATP6V0B ATP6V1G1 CDH1 ATP6V0E1 CTNNB1 MET ATP6V1B2 ATP6V0D1 CDKN1A ATP6V0C CDKN2A CCND1 ATP6V1A ATP6V1H SMARCA2 SMARCA4 ATP6V1C1 BCL2 CDK2 ACTL6A MAPK14 TCF7 GXYLT2 CDH2 STT3B SMARCD3 PXN TERT EDIL3 CEACAM1 ZEB1 SIN3A PXDN BIRC7 ASAH1 BCL2A1 TBX2 TFAP2A PPARGC1A SMARCD1 SMARCD2 ITGA2 SIRT1 LEF1 DIAPH1 TCF7L2 SMARCE1 TCF7L1 TNRC6C TNRC6A TNRC6B SERPINE1 CDC25B HINT1 DCT TYRP1 TYR POU3F2 SOX10 HDAC1 ACTB GMPR PMEL BCL7A MLANA BCL7C DPF1 MYO5A BCL7B DPF2 DPF3 BRCA1 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 ARID1A GPR143 ARID1B AKT2 SOX2 DICER1 TRPM1 MOV10 AGO3 AGO4 USF1 AGO1 AGO2 MCM5 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE TICAM1 TRAF3 TLR3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2I POLR2J POLR2K POLR2L PIWIL2 TDRKH PIWIL1 PIWIL4 DDX4 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 PLD6 FKBP6 HSP90AA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling HRAS SOS1 IRS1 IRS2 NRAS INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells CTNNB1 CBLL1 UBB UBA52 SRC UBC CTNND1 RPS27A CDH1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy ARL13B UBA52 PCNT CETN1 HSP90AA1 PARK7 RNASE1 HDAC6 GFAP LAMP2 PLIN2 CFTR HBB UBB PLIN3 HSP90AB1 UBC IFT88 RPS27A HSPA8 EEF1A1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals MT1E MT2A MT1A MT1M MT1F MT1G MT1X MT1H MT4 MT1B MT3 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair OGG1 NTHL1 NEIL3 NEIL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters LEF1 CTNNB1 AXIN2 MYC TCF7 TCF7L2 TCF7L1 RUNX3 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle POM121C NUP42 NUP62 FURIN TPR BANF1 NUP88 RAE1 KPNA1 NUP214 LIG1 NDC1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP107 NMT2 NUP160 NUP85 XPO1 SEC13 NUP133 PDCD6IP RANGAP1 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PPIA CD4 RCC1 NUP43 NMT1 CCR5 CCNK CHMP2B RANBP1 CCNT2 CHMP2A ELL CCNT1 RANBP2 GTF2B UBA52 TAF7L ELOA RAN ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 UBB CTDP1 TAF9 SUPT4H1 UBC TAF1L GTF2E1 GTF2E2 RPS27A NUP37 TAF15 FEN1 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 NEDD4L CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 LIG4 XRCC4 CXCR4 TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 CHMP5 NUP205 XRCC6 POM121 XRCC5 NUP188 PSIP1 AAAS DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 AKT1 DCP2 MAPK11 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC CASP3 UNC5A DAPK1 MAGED1 UNC5B DAPK2 DAPK3 APPL1 CASP9 DCC LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome WDR5 RBBP5 ASH2L DPY30 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2CA PPP2CB ATM PPP2R1B PPP2R1A PHF20 UBA52 CHEK2 TP53 MDM2 MDM4 USP7 CCNG1 USP2 CDK1 PRR5 AKT2 UBB AKT3 CCNA2 UBC AKT1 CCNA1 RPS27A MLST8 PDPK1 SGK1 MAPKAP1 RICTOR CDKN2A PPP2R5C RNF34 DAXX RFFL CDK2 MTOR INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TKT TALDO1 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS EXT1 EXT2 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 AGRN MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase CEP57 CETN2 PLK1 CEP164 ACTR1A CCNB1 PCM1 CNTRL CDK1 CEP290 NINL NEK9 NEK6 NEK7 OFD1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 ERCC6L CEP63 NUP107 ZWILCH NEK2 BUB1B SFI1 SMC3 CDC20 SDCCAG8 PPP1CC PPP2R1B PPP2R1A KNTC1 DCTN2 KNL1 SSNA1 SGO1 DCTN3 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 HAUS8 ZW10 HAUS7 MAD1L1 CDCA5 PCNT CDCA8 PDS5B CEP152 PDS5A PMF1 CSNK1E NUP160 SKA1 SKA2 CCNB2 NEDD1 DSN1 NUP85 ALMS1 RAD21 RCC2 NDC80 WAPL CEP41 ZWINT CEP43 STAG1 XPO1 KIF18A STAG2 RPS27 AHCTF1 YWHAG PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 HSP90AA1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 YWHAE DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP SMC4 CENPQ SMC2 SPC24 TUBGCP2 MAD2L1 NCAPG CENPS NCAPH NUP37 TUBGCP5 SPC25 TUBGCP6 TUBGCP3 CPAP TUBGCP4 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 NCAPD2 AKAP9 PRKAR2B TUBA4A PRKACA FIRRM CCP110 CEP250 CDK5RAP2 CEP135 CEP131 EML4 CSNK1D TUBA1A CSNK2A1 CSNK2A2 CSNK2B CEP70 CEP72 CEP192 CEP76 CEP78 PLK4 ODF2 TUBB4B TUBB4A RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCB NCF2 NCF4 NOXA1 NOX3 RAC2 PIK3C3 NOX1 S100A9 S100A8 PRKCD PRKCA RAC1 CYBB PIN1 MAPK1 CYBA MAPK3 NOXO1 PIK3R4 PRKCZ MAPK14 MAPK11 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 TREX1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACADS ECHS1 ACSM3 ACSM6 HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) H2AC6 H2AC7 H2AX KDM5B H3-3B H2AC19 H2AC14 KDM6B H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 KDM5A UHRF1 KDM6A H2BC1 H4C9 STPG4 AICDA METTL23 DPPA3 TET3 H2AB1 H2AZ2 H2AC20 H2AC8 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia PROS1 PROC F5 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR2K POLR2L POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation IFNA8 IFIH1 RNF135 TBK1 TRIM25 IFNA21 IRF3 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI TANK IKBKE EP300 TRIM4 IFNB1 CREBBP TRAF2 IRF7 TRAF6 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events ANO7 ANO4 ANO5 FURIN ANO2 ANO3 ANO1 MAGT1 UBA52 ANO10 UBB UBC RPS27A PRMT1 TMPRSS2 ACE2 UBE2I ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 TUSC3 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 SUMO1 MGAT5 ST3GAL4 GSK3A MGAT1 PARP6 MGAT2 GOLGA7 PARP4 TMEM258 ST3GAL1 GALNT1 ST3GAL2 PARP16 PARP9 ST3GAL3 ST6GAL1 PARP14 PARP8 EDEM2 MOGS PARP10 ZDHHC11 MGAT4C ZDHHC9 SRPK2 MGAT4A OST4 SRPK1 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 OSTC STT3A CSNK1A1 STT3B GSK3B RPN2 DDOST RPN1 DAD1 CANX ANO8 ANO9 ANO6 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u DPM1 DPM2 DPM3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 CHUK UBE2N UBE2V1 UBA52 RIPK3 UBE2D1 UBE2D2 TICAM2 UBE2D3 TICAM1 IKBKB TLR4 LY96 BIRC2 UBB TRAF6 CD14 BIRC3 UBC RIPK1 IKBKG RPS27A RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry FURIN SDC1 GPC1 CX3CR1 HSPG2 EGFR RAB5B GPC3 RAB5C IGF1R GPC2 SDC4 NCL SDC2 GPC5 RAB5A SDC3 GPC4 TLR4 GPC6 LY96 CD14 AGRN RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 H2BC17 H2BC12 H2BC13 NEIL3 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes CYB5R2 CYB5R1 CA1 CYB5R4 CA2 HBB CA4 SLC4A1 CYB5RL RHAG AQP1 HBA2 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNMB1 KCNA10 KCNMA1 HCN4 HCN3 KCNN2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNQ2 KCNA7 KCNQ3 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK6 KCNK2 KCNK7 HCN2 KCNK1 KCNK3 HCN1 KCNK4 KCNQ4 KCNJ8 ABCC8 KCNJ2 KCNJ3 KCNJ4 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 KCNJ12 KCNJ9 KCNJ15 KCNJ16 GNGT1 GNGT2 ABCC9 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNG1 KCNJ11 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 KCNN1 KCNN3 GNB2 KCNN4 KCNF1 GNB1 KCNC1 GNB4 KCNK9 GNB3 KCNC2 GNB5 KCNC3 KCNC4 KCND1 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction CALM1 ANXA2 PXN TRIM72 GUCY1B2 GUCY1B1 ALDH2 ITGB5 DYSF LMOD1 MYL6B CACNA1H MYL12A PAK1 MYLK MYL12B CACNA1G CACNA1I CALD1 ANXA6 PAK2 MYL10 MYH11 GUCY1A2 GUCY1A1 ANXA1 CAV3 TPM4 ITGA1 TPM3 MYL11 PDE5A TPM2 TPM1 SORBS1 SORBS3 MYL5 MYL6 TLN1 MYL7 VCL MYL9 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 HSP90AA1 CDC37 HRAS SOS1 ERBIN PTPN12 ERBB2 SHC1 NRAS RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) CR1 TNFRSF18 NFATC2 CBFB IFNG RUNX1 CTLA4 IL2RA FOXP3 IL2 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b MOGS DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG GALE MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation CHUK FBXW11 UBA52 CUL1 MAP2K4 TNIP2 MAP2K1 IKBKB UBB UBC IKBKG BTRC RPS27A MAP3K8 NFKB1 SKP1 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction HCK DOCK2 ELMO1 FYN PAK2 LCK RAC1 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins NOTCH1 NOTCH2 NOTCH3 NOTCH4 POMT2 SEMA5A GALNT12 SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTS4 ADAMTSL1 LFNG ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 DAG1 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 MUC13 THSD7A MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 POMGNT1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 B4GAT1 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 MUC16 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling BTK ARHGEF6 PLCB3 PLCB1 PLCB2 GNG10 GNG3 GNG2 GNG5 AKT2 GNG4 GNG7 AKT3 RHOA GNG8 AKT1 PIK3CG PAK1 PDPK1 PIK3R6 PIK3R5 GNGT1 GNGT2 CDC42 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification MGST1 DPEP2 MGST2 CYP3A4 DPEP1 ACY1 AKR7L CYP3A5 AKR7A2 AKR7A3 GGT3P GGT5 CYP2A13 CYP1A2 ACY3 GGT7 GGT6 MGST3 GGT1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events MAPK7 NRAS MAPK1 HRAS MAPK3 DGKG DGKE DAGLA DGKD DGKB DGKA PRKCQ ABHD6 SOS1 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI RASGRP2 DGKH TRIO ARHGEF25 PIK3CA ADRA1D RASGRP1 ADRA1B ADRA1A APP KALRN TBXA2R EDNRB RPS6KA1 EDN1 EDN3 GNGT1 CHRM3 CHRM1 GNGT2 CHRM5 HTR2B HTR2C HTR2A HRH1 MGLL BTK GPR143 GNAQ GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CYSLTR1 CYSLTR2 GCGR GNA14 GNA15 GNA11 GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 PLCB4 HBEGF ANXA1 EGFR NPFFR2 NPFFR1 RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 NTSR2 GPR17 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 OXTR QRFP MLN AVPR1B BRS3 GPRC6A OXT GPR132 AVP CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 SAA1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 GRK2 PRKCD PRKCA RGS5 PLCB3 RGS2 PLCB1 RGS3 PLCB2 RGS1 GHSR CASR F2R LTB4R2 UTS2 ITPR1 NTS ITPR2 KNG1 MCHR2 ITPR3 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 GRM5 MCHR1 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 PIK3R3 XCL2 PIK3R2 XCL1 PIK3R1 RGS18 RGS17 RGS19 RGS13 TRPC7 RGS16 P2RY6 RPS6KA3 P2RY2 RPS6KA2 TRPC6 P2RY1 TRPC3 RGS21 CCK HCRTR2 HCRTR1 KISS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules CD4 HLA-DRB3 HLA-DRB1 PLCG2 CD3G CD3E CD3D WAS TRAV19 HLA-DPA1 HLA-DRA VASP TRBC1 ENAH HLA-DQB2 HLA-DQB1 TRBV12-3 PAK1 TRBV7-9 PAK3 PAK2 LCK NCK1 TRAV29DV5 HLA-DQA2 EVL HLA-DRB5 TRAV8-4 HLA-DRB4 HLA-DPB1 PLCG1 ITK FYB1 ZAP70 TRAC LCP2 LAT GRAP2 CD101 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin VWF F2 F8 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs CDH11 TNRC6A TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 PDPK1 GAB2 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 SYK PIK3R2 PIK3R1 LYN LAT2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDK6 CDK4 CDKN2A SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis DLD OGDH DLST KGD4 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 MCCC1 PPM1K AUH IVD HIBCH ECHS1 ACAT1 BCKDK BCKDHA DBT BCKDHB DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants ITGA2B CALM1 FN1 CAMK2B CAMK2D CAMK2A SRC CAMK2G ITGB3 ARAF ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling NOTCH1 RBX1 CUL1 SKP1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching PCNA POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RFC5 RFC3 RFC4 RFC1 RFC2 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ITGA2B H2AX TNRC6A TNRC6B ASH2L GATA1 ZFPM1 H3-3B CBFB H3C8 RUNX1 H2AJ PRMT6 KMT2D PRMT1 GP1BA H3C15 KMT2B NFE2 HDAC1 H2BC9 H2BC8 H2BC5 SETD1B H2BC3 SETD1A H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 PRKCQ NR4A3 KMT2A KMT2C KAT2B H2AC19 H2AC14 H2BC12L SIN3B THBS1 DPY30 SIN3A H2BC26 H2BC21 WDR5 EP300 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H4C9 RBBP5 MOV10 AGO3 PF4 H2AZ2 AGO4 MYL9 H2AC20 AGO1 TNRC6C SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression PRDM1 TP53 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function ADAM33 ADAM19 JUP CTNNB1 CDH11 ANGPTL4 CDH8 CTNND1 CTNNA1 CDH24 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex TAB3 TAB2 TAB1 TICAM1 UBB TRAF6 UBA52 TLR3 UBC RPS27A MAP3K7 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis DNA2 PCNA LIG1 POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RFC5 RFC3 RPA1 RPA2 RFC4 RFC1 RFC2 RPA3 FEN1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL HCK RAPGEF1 CRK PIK3R3 SYK PIK3R2 BLNK PIK3R1 PIK3CA CRKL LYN YES1 FYN VAV1 PIK3CD PIK3CB CBL GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN KDM8 STS OGFOD1 EIF5A F8 ARSA JMJD4 DHPS FN3KRP JMJD7 SUMF2 SUMF1 JMJD6 TPST2 F7 TPST1 F9 RCCD1 EIF5A2 PROZ DNAJC24 ARSL DPH1 ARSJ DPH2 ARSK DPH3 ARSH ARSI DPH5 ARSF ARSB DPH6 ARSG PROS1 DPH7 ARSD ZC3H15 RPL8 RWDD1 FN3K ICMT F10 DOHH RIOX1 GGCX RIOX2 DRG1 GAS6 DRG2 F2 PROC EEF2 RPS6 ASPH BGLAP U2AF2 RPL27A RPS23 ETF1 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGF NGFR HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA SET ANP32A TNFSF13 NUP214 ELAVL1 PRKCD PRKCA XPO1 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation EIF5A2 EIF5A DHPS DOHH MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E UBB UBA52 UBC RPS27A REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade VTN CD59 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 CD81 V3-3 C4BPA V2-17 C4BPB V3-2 CLU IGHV3-33 V2-15 SERPING1 IGKV1D-39 CPB2 V2-19 CFH IGKV1D-33 C5AR2 C5AR1 IGKV2D-28 CFI IGKV4-1 C6 IGHV7-81 C7 C9 CD19 V1-11 C8B IGKV2D-30 C8A V1-16 C8G V1-13 CR2 IGHV4-59 CD46 IGHV1-69 CPN2 CPN1 CFHR2 IGLV2-11 CFHR1 IGLV1-40 CFHR4 IGLV1-47 CFHR3 IGLV6-57 CFHR5 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CR1 C3 C4A IGKV3-20 C5 IGHV4-34 C4B_2 IGHV1-2 CFB IGHV1-46 C2 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 ELANE IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PROS1 F2 C3AR1 IGHG3 IGHG4 IGHG1 IGHG2 CD55 C1QB C1QA C1S C1R C1QC CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis CD3G CD3D TFRC SYNJ1 SH3GL3 SH3KBP1 STAM CBL HGS EPS15 TGFA STAM2 SYT2 SH3GL2 SH3GL1 SYT1 EREG BTC DNM1 VAMP2 EPGN DNM3 HBEGF NEDD8 CLTB EGF AREG HSPA8 TF M6PR DNM2 VAMP8 VAMP7 DNAJC6 EGFR COPS5 SCARB2 ITSN2 SLC18A3 AGFG1 GAPVD1 BIN1 AMPH GRK3 CLTCL1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A SYNJ2 TOR1B APOB SYT9 FNBP1L SYT8 FNBP1 SNAP91 DAB2 AAK1 IL7R PICALM CLTC ITSN1 STON1 CLTA STON2 PIK3C2A SLC2A8 SGIP1 EPS15L1 OCRL ARFGAP1 EPN1 EPN2 GAK CFTR CTTN ARF6 LRP2 FCHO1 FCHO2 REPS2 UBQLN1 UBQLN2 COPS7B HIP1R COPS7A SNX18 NECAP2 CD4 NECAP1 SYT11 TRIP10 COPS3 COPS6 AP2A1 AP2A2 VAMP3 COPS8 UBA52 VAMP4 LDLRAP1 AP2M1 AGTR1 TGOLN2 UBB UBC IGF2R RPS27A AP2S1 AVPR2 LDLR AVP CHRM2 AP2B1 TACR1 ADRB2 WNT5A ARPC1A WASL GRK2 RAB5B RAB5C RAB5A HIP1 GPS1 DVL2 FZD4 ARRB1 ARPC4 ARPC5 ARRB2 ARPC2 ARPC3 COPS4 COPS2 ACTR3 ACTR2 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate SUOX TST ETHE1 SLC25A10 TSTD1 SQOR HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones SAP30 BRMS1 H2BC18 PHF21A MTA2 SUDS3 HDAC10 REST RCOR1 HMG20B SAP30L SAP18 H3C8 H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC8 H2AC6 H2AC7 H2AC17 H2AC12 NCOR2 H2AC1 HDAC3 H2AC19 H2AC25 H2AC14 H2AC21 MBD3 GPS2 H2BC26 H2BC21 GATAD2B TBL1X GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 KDM1A HDAC2 H2BC11 HDAC8 NCOR1 TBL1XR1 H4C9 CHD4 RBBP4 CHD3 RBBP7 ARID4A ARID4B H2AC20 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle GOT2 SLC25A18 MDH1 MDH2 SLC25A12 SLC25A11 SLC25A22 SLC25A13 GOT1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine GLYAT ACSM1 GLYATL3 ACSM2B GLYATL2 GLYATL1 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription RETN INS FASLG STK11 SFN SOD2 FOXO3 IGFBP1 PCBP4 ABCA6 BCL2L11 GADD45A CITED2 YWHAZ FOXG1 FOXO6 NPY CDKN1A FOXO4 CDKN1B BBC3 FOXO1 HDAC1 ATXN3 YWHAB PCK1 POMC NR3C1 MSTN SMAD2 CAV1 PLXNA4 SMAD4 SMAD3 SIRT3 BTG1 SREBF1 FBXO32 G6PC1 BCL6 NFYA NFYB NFYC GCK KAT2B CCNG2 RBL2 AKT2 AKT3 SIN3A AKT1 TRIM63 YWHAG EP300 PPARGC1A AGRP HDAC2 CREBBP SIRT1 DDIT3 YWHAQ TXNIP TXN PINK1 KLF4 CAT THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PLK1 UBA52 TP53 PSMD12 GTSE1 PSMD11 FKBPL PSMD14 PSMD13 CCNB1 PSMA7 PSMB6 CDK1 PSMB7 CCNB2 PSMB4 PSMB5 UBB PSMB2 PSMB3 HSP90AB1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 HSP90AA1 PSMD8 PSMD6 MAPRE1 PSMD7 PSMD2 PSMD3 PSMD1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP2B CHMP2A PIK3C3 BECN1 UVRAG MAP1LC3B ISCU CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PIK3R4 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly H2AX CENPT CENPU CENPH CENPI HJURP CENPK RSF1 CENPL MIS18BP1 CENPM OIP5 CENPN CENPW CENPX CENPO MIS18A CENPP H2AJ CENPQ CENPS H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KNL1 NPM1 H2AC19 H2AC14 H2BC12L SMARCA5 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RUVBL1 H4C9 RBBP4 ITGB3BP RBBP7 H2AZ2 CENPA H2AC20 CENPC VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release CALR CANX ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2AC6 H2AC7 H2AX H3-3B H2AC19 H2AC14 H3C8 H2BC12L KLK3 H2AJ KLK2 KDM4C H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 NCOA2 KDM1A H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 H2AB1 H2AZ2 PKN1 AR H2AC20 H2AC8 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation POLR2I POLR2J POLR2K POLR2L FGFR2 GTF2F1 GTF2F2 NCBP1 NCBP2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import UBA52 HMGCL UBE2D1 PEX2 ACOT8 UBB EHHADH HSD17B4 ACAA1 UBC PECR DECR2 PEX10 ZFAND6 RPS27A PEX12 IDE SLC27A2 PEX13 CROT ACOT4 PEX14 PEX26 SCP2 NUDT19 MPV17 GSTK1 PHYH ECH1 PIPOX PEX1 BAAT PEX7 ACOX2 ACOX1 UBE2D2 PEX6 AGPS ACOT2 ACOX3 AGXT PAOX DDO HACL1 HAO1 HAO2 IDH1 NOS2 EPHX2 TYSND1 LONP2 DHRS4 NUDT7 AMACR DAO CRAT GNPAT USP9X UBE2D3 CAT GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling CSH1 STAT5A PRLR PTPN6 STAT5B GHR GH2 SOCS2 GH1 ADAM17 SOCS3 SOCS1 JAK2 STAT1 LYN STAT3 MAPK1 MAPK3 IRS1 PTPN1 IRS2 CISH PRL TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses GJA10 GJC1 PANX1 GJD2 PANX2 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease EZH2 CD3G MAGT1 RAC1 JAK1 H3C8 VAV1 H3C15 RICTOR PAK2 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 ATP6V1H H2BC1 TUSC3 NEK2 H2AC8 H2AC6 H2AC7 ZBP1 TBK1 TMEM258 IRF3 VCP OST4 NFKB2 OSTC STT3A STT3B PRR5 GSK3B H2BC26 H2BC21 MLST8 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 LCK H2BC11 CDC42 RBBP4 FYN RBBP7 PTPN11 MTOR CD4 PTPN6 PDCD1 HDLBP AP2A1 CCNK CCNT2 AP2A2 ELL CCNT1 PRKACG GTF2B TAF7L ELOA PRKACB ELOB NELFB AP2M1 ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 ELOA2 SSRP1 AP2S1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 AP2B1 GJA1 ACTB P4HB ENO1 HSPG2 SDC4 SDC2 SDC3 LIG4 XRCC4 SDC1 NUP205 ARID4A POM121 ARID4B FNTA NUP188 FNTB PSIP1 AAAS IL1R1 SAP30 POM121C BRMS1 NUP42 NUP62 IFNAR1 PHF21A TPR BANF1 CD79B NUP88 CD79A RAE1 SUDS3 KPNA1 RCOR1 IGHM NUP214 NDC1 BLNK HMG20B NUP210 JAK3 NUP155 GPC1 HMGA1 IFNGR1 NUP153 IFNGR2 SIGMAR1 NUP93 GPC3 NUP50 TYK2 IGHD NUP35 GPC2 NUP54 SAP30L SLC25A5 S1PR1 SLC25A4 SAP18 GPC5 CRBN SLC25A6 GPC4 STAT2 GPC6 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 AGRN CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 RPL4 PAPOLA SYMPK RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 TKFC RPL35 KPNA4 RPL38 KPNA5 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPS4Y2 RPS4Y1 RPL39L CPSF4 RPL41 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 CDC73 HSPA1A HLA-B SKIC8 RUNX1 CTR9 TRAF3 RTF1 CD14 IKBKE LEO1 PAF1 FASN RNASEK PROS1 CLDN1 HNRNPU MTA1 MRC1 EMC4 CD33 MTA3 HSPA5 CD300A TIMD4 MERTK EIF4A3 AXL TYRO3 MAPRE3 GAS6 LY6E CDC40 SRRM1 SRSF2 SRSF3 GSK3A SRSF4 PARP6 SRSF5 PARP4 SRSF6 GALNT1 SRSF7 PARP16 PARP9 SRSF9 PARP14 PARP8 PARP10 PRKG2 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 PRKAR1A TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 CHMP5 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 ANO10 HLA-A B2M AP1M2 AP1M1 TUFM UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 V1-11 IGKV2D-30 V1-16 NMT2 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 CSNK1A1 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CD209 UBE2N TAB3 TAB2 TAB1 ITGB1 IGKV3-20 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 ELMO2 RCC1 IGKC DOCK2 NMT1 IGLV3-21 DOCK1 CCR5 IGKV1-39 IGKV1-33 RAB7A RANBP1 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YWHAH YWHAZ PPP1CB HDAC1 PPP1CA CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 VAV3 IFNA17 SIKE1 PTK2 MAVS IFNA10 RIGI SRPK2 SRPK1 CX3CR1 VAV2 RAB5B IMPDH1 RAB5C IGF1R NCL IMPDH2 PRKAR2A RAB5A NRP1 HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 MYO9B ACTG1 CPSF7 NCK1 VIM HNRNPC RBMX FURIN DPM1 DPM2 DPM3 RPTOR PGK1 EIF4E EIF4G1 STX1B SNAP25 TMPRSS2 ACE2 SYT2 SV2C HAVCR1 SYT1 ELK1 SV2B SV2A VAMP1 VAMP2 STX1A HBEGF ARF1 SEC23A SAR1B HSPA8 SCAP SEC24B SEC24A COMT SP1 SEC24D SEC24C PIK3R4 CASP4 CASP1 TLR9 PIK3C3 PDCD6IP RIPK3 IL18 IL1A IL1B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 IL6R RIPK1 KEAP1 UBE2L6 GSDMD HERC5 ITCH CHMP2B CHMP2A RNF213 ATG7 TRIM4 F2 AHCYL1 PRKACA ATP1B3 ATP1B2 ATP1B1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ATP1A3 ITPR2 ATP1A2 ITPR3 ATP1A1 CAMK2G CUL5 UBA7 UBA6 UBA5 UBR4 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 MAP2K4 TXN MAP2K7 UBA3 UBA1 IL6 MAPK8 IFNB1 VHL PLCG1 ELAVL1 C4BPA C4BPB BCL2L1 CLU EEF1A1 EEF2 ADAM17 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 NCKAP1 C3 C4A BRK1 C4B_2 GUCY2C CYBA NOXO1 NCKAP1L WASF1 WASF2 BAIAP2 H2BC18 ABI2 NOXA1 ABI1 NOX1 BECN1 UVRAG MAP1LC3B ISCU HCK CD8B ELMO1 ACOT2 UPK1A EPCAM ST6GALNAC2 PRKCSH CYFIP2 ZDHHC20 ZDHHC5 WIPF1 NOS2 ZDHHC8 WIPF2 ZDHHC2 WIPF3 ZDHHC3 GNAT3 C3AR1 FUT8 GANAB ENTPD1 ENTPD5 MAN2A1 MGAT5 ADCY9 PRKAR1B ST3GAL4 BTK MGAT1 MGAT2 MEFV PRKAR2B GOLGA7 PLCG2 ST3GAL1 MYO5A ST3GAL2 ST3GAL3 ARPC1B GBP6 ST6GAL1 ARPC1A LARP1 EDEM2 WASL GRPEL1 MOGS CTSG HYOU1 SYK ZDHHC11 MED19 GNAI3 MGAT4C MED18 ZDHHC9 ADCY4 PQBP1 MGAT4A WAS MED11 ADCY3 MGAT4B MED29 PRKX MAN1B1 MED28 ST6GALNAC3 ADCY2 MED22 ST6GALNAC4 ADCY1 MED21 ADCY8 ATL2 ADCY7 SRRT ADCY6 VPS33A GNAI1 VPS33B ADCY5 ZCRB1 GNAI2 SNRNP200 NT5E CORO1A PYCARD G3BP1 IGHG3 G3BP2 IGHG4 FUS IGHG1 NACA CYSLTR1 ISY1 IL10 IGHG2 BCAS2 CYSLTR2 CD163 CTNNBL1 GGT1 PLK2 PRCC DPEP2 RHBDF2 HNRNPA1 DPEP1 MYH9 HNRNPA0 GNAZ HNRNPA3 NCKIPSD GPKOW DVL1 CNBP DVL2 CDC5L DVL3 KDELR1 NLRP3 CCAR1 GGT5 ARPC4 CD2BP2 ARPC5 PCBP1 ARPC2 PCBP2 ARPC3 RBM10 MED13L PSTPIP1 FCGR3A BST2 ACTR3 CALM3 ACTR2 RETREG1 CALM2 FGR SUGP1 MYH2 ADORA2B DHX15 FCGR1A DHX16 UFD1 WASF3 MYO10 ARIH1 SFTPD P2RX7 BCAP31 P2RX4 TXNIP FCGR2A PEX19 MYO1C NLRP12 HNRNPA2B1 SUGT1 IL17F TRIM27 IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG PPIB RTN3 DDX3X DDX46 DDX42 SFN RBM17 LIG1 SUN2 DYNLT1 BUD31 MMP9 SFPQ RBM22 DDX23 RRBP1 SMNDC1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM HNRNPK NPLOC4 HNRNPF HNRNPD CLINT1 MED16 SF3B4 MED15 SF3B5 MED17 SF3B2 SF3B3 MED12 SF3B6 MED14 SF3B1 MED13 SF3A3 SF3A1 SF3A2 MED10 XAB2 PHF5A HSPA1B CLEC4M AUP1 IPO7 CD9 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 MED27 P4HA2 MED26 P4HA3 RCAN3 EIF4G3 MED23 EIF4G2 MED25 EIF4E3 MED24 DUSP16 PTBP1 MED20 PLRG1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 VPS41 EGFR NPIPB3 VPS45 PPIL3 PPIL4 PPIL6 SRRM2 AQR HLA-H HLA-C HLA-F CRNKL1 HLA-G MBD3 HLA-E NMI PRPF19 CHMP1A TOMM70 IL17RC IL17RA TLR1 GATAD2B HNRNPH1 GATAD2A HNRNPH2 TLR6 TLR2 SPCS3 SPCS2 SPCS1 CWC25 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 PSMD8 OAS2 IKBKB LTF PSMD6 GBP2 PSMD7 GBP4 PSMD2 NHERF4 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RIPK2 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NFKBIB MED30 NOD1 NOD2 MED31 IRAK2 UBE2I NR3C1 SUMO1 ITGA4 CCNC TRIM28 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 HGS CTNNB1 EPS15 CBLL1 MET STAM2 SH3GL2 SH3GL1 TUBB YWHAB MAPK1 SNW1 MAPK3 MAP2K1 MAP2K2 MAPK14 CTSL EXOC1 SOS1 CRK NPM1 GBF1 HDAC3 LY96 HBB XPO1 HMOX1 EP300 TBL1X IRAK1 MED1 CREBBP APOA1 HBA2 NCOR1 TBL1XR1 CHD4 CHD3 TLR4 NFE2L2 YWHAQ PPIA FKBP1A CALM1 MTA2 YWHAE COG1 REST JUN MED8 MED4 MED6 MED7 RBX1 NEDD4L GNGT1 GNGT2 WNT5A NCOR2 TAL1 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GPS2 XRN1 FZD7 KDM1A FKBP4 DDX5 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 CUL3 NRBP1 RB1 ABL1 DAXX NUP107 PPP1CC CDK8 DYNC1LI1 DYNC1LI2 NUP160 NUP85 RPS27 SEC13 NUP133 HDAC2 DYNLL1 RANGAP1 DYNLL2 DYNC1I2 TXNRD1 PML NUP43 DYNC1I1 RANBP2 DYNC1H1 TAOK1 NUP37 FEN1 PRMT1 EIF4A2 EIF4A1 TJP1 CCNH RNMT POLR2A POLR2B POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 YBX1 CDK7 ERCC3 H2AC17 ERCC2 H2AC12 MNAT1 H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 AKT2 TLR8 TLR7 AKT3 TLR3 AKT1 CSNK2A1 CSNK2A2 CSNK2B MASP1 MBL2 RPN2 MAPKAP1 C1QA RPN1 C1S PIK3R1 JAK2 CGAS LYN YES1 IRF7 H4C9 DHX9 XRCC6 XRCC5 H2AC20 STING1 CD28 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 EXT1 EXT2 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 AGRN RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR ELF1 CBFB RUNX1 IL3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX5 ALOX12 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis DICER1 ELAC2 ANG CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A3 SULT1A2 SULT2A1 SULT1C4 TPST2 TPST1 PODXL2 ABHD14B SULT1A1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNK CCNT2 ELL CCNT1 ELOA AFF4 ELOB CDC73 NELFB MLLT1 ELOC MLLT3 NELFCD SUPT6H NELFA IWS1 NELFE EAF1 SUPT16H EAF2 NCBP1 SKIC8 NCBP2 CTR9 CTDP1 RTF1 SUPT4H1 LEO1 PAF1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes KCNU1 CATSPER1 CATSPERB CATSPER3 CATSPERD CATSPER2 CATSPERG CATSPER4 HVCN1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle RHOT2 RAP1GDS1 TRAK1 MFN1 MFN2 MYO19 TRAK2 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 RAPGEF1 LAMA4 LAMA3 CRK LAMC2 LAMB1 PTK2 LAMC1 RAC1 HGF DOCK7 TNS4 SRC TNS3 MET ITGB1 RAP1B CRKL ITGA3 ITGA2 RAP1A GAB1 LAMA5 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation POM121C PHC2 NUP42 NUP62 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 PHC3 CETN2 NDC1 NUP210 NUP155 TRIM28 NUP153 NUP93 MDM2 NUP50 NUP35 NUP54 BMI1 RING1 RNF2 HNRNPK FOXL2 HIC1 L3MBTL2 SP3 CDKN2A VHL SUZ12 DAXX NUP107 SMC3 SATB2 NPM1 CDCA8 NFKB2 NUP160 NUP85 RAD21 SIN3A EIF2AK2 STAG1 CTBP1 STAG2 NRIP1 EP300 SEC13 PPARGC1A TFAP2B NCOA1 NUP133 TFAP2C NCOA2 CREBBP HDAC2 SMC1A RANGAP1 PARK7 PARP1 INCENP HDAC7 BIRC5 CHD3 IKBKG AURKB XPC PML AURKA NUP43 HERC2 RANBP2 DNMT3B DNMT3A DNMT1 RELA IKBKE SMC5 SMC6 NUP37 DDX17 NSMCE3 NSMCE2 MITF NSMCE1 NFKBIA MRTFA EID3 ZBED1 UBA2 SAE1 TOP2A TOP2B ZNF131 MTA1 SENP5 HDAC1 SENP2 SAFB PIAS4 SENP1 NSMCE4A HDAC4 PIAS3 TOP1 THRB SP100 UBE2I TOPORS UHRF2 VDR SATB1 CASP8AP2 NR1H2 RORA NOP58 NR3C1 RWDD3 NR2C1 MBD1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR CBX5 RXRA SUMO1 TP53BP1 SUMO3 SUMO2 RARA PGR RNF168 PPARG PPARA ING2 BRCA1 RAD52 TP53 NCOR2 XRCC4 ZNF350 MDC1 TDG BLM PCNA WRN PCGF2 DDX5 HIPK2 H4C9 HNRNPC RPA1 NUP205 POM121 NUP188 TRIM27 AAAS CBX8 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 FGF9 FGF20 FGF23 FGF16 SOS1 FGF18 PIK3R1 PIK3CA NRAS GAB1 FRS3 HRAS PLCG1 FRS2 FGF1 FGF2 PTPN11 FGF4 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling PTPN7 PTPN6 PTPN5 IL18R1 TBK1 PTPN2 PTPN4 CASP1 STAT3 PTPN18 IL37 PTPN20 PTPN12 PTPN23 SMAD3 PTPN13 PTPN14 PTPN11 IL18BP SIGIRR PTPN9 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK2B CAMKK1 CAMKK2 CALM1 CAMK4 CAMK2G KPNA2 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease SKIC2 DIS3 HBS1L EXOSC7 NT5C3B EXOSC6 EXOSC5 SKIC3 EXOSC4 DCPS EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines EZH2 KMT2A ASH2L NSD2 KMT2C SUV39H2 SETD2 SETD3 PRDM9 NFKB2 SETD6 SUV39H1 DOT1L RELA SETD7 NSD3 MECOM H3C8 NSD1 KMT5B SMYD3 ATF7IP DPY30 SETDB1 KMT5C SETDB2 ASH1L KMT2D AEBP2 NFKB1 WDR5 H3C15 EED KMT2B PRDM16 SUZ12 EHMT2 EHMT1 SETD1B SETD1A SMYD2 H4C9 RBBP4 RBBP5 RBBP7 KMT5A DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine GOT2 FMO1 SUOX TST CTH ETHE1 SLC25A10 CDO1 GADL1 CSAD ADO TXN2 MPST TSTD1 SQOR METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway MTAP APIP MRI1 ADI1 ENOPH1 GOT1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress TXNRD2 SOD3 ATOX1 SOD1 CCS AMER1 CDKN2A ABCG2 STAT3 COX7B EGF HMOX2 BCL2 PDGFA AREG COX7C BCL2L1 COX8A COX8C COX5B COX5A VCP COX6C HDAC3 SMARCD3 CHD9 COX6A1 HBB COX6A2 GSK3B BACH1 HELZ2 G6PD COX6B2 TGS1 COX6B1 HMOX1 NCF1 NCF2 EP300 TBL1X NCF4 HIGD1C NCOA1 MED1 NCOA2 CREBBP NCOA6 HBA2 CYBB PRKAA2 NCOR1 CYBA TBL1XR1 CARM1 MAFK NFE2L2 CAT SOD2 MAP1LC3B FBXL17 PRDX2 PRDX1 SLC7A11 NOTCH1 RBX1 PTK6 FABP1 ALB P4HB IDH1 TALDO1 NCOR2 GSTA1 NOX4 MT-CO1 NLRP3 UFD1 TXNIP MT-CO2 MT-CO3 TKT CUL3 NPLOC4 CDKN1A PGD SQSTM1 SKP2 SP1 SIN3A GPX2 PSMD8 PSMD6 PSMD7 TXN2 PSMD2 PSMD3 SESN2 PSMD1 TXNRD1 BTRC KEAP1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CYCS TRIM21 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRKCI COX7A2L CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 COXFA4 COX7A2 ABCC1 COX7A1 RXRA PPARA BRCA1 PRKCD COX4I1 COX4I2 AKT2 MYC AKT3 AKT1 EIF2AK3 CSNK2A1 AQP8 CSNK2A2 NUDT2 CSNK2B ATF4 PRDX3 PRDX6 NOX5 UBXN7 GSTP1 NQO1 GSTA3 ERO1A SESN1 MUL1 DPP3 STAP2 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 GPX1 GPX3 GPX6 PALB2 GPX5 GPX8 TXN GPX7 ATP7A BLVRB BLVRA HM13 CCL2 ABCF2 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein MGAT1 PRKCSH CANX MOGS GANAB PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 PIK3R1 PIK3CA FGF10 GAB1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FGF7 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN RIT1 RIT2 NTRK1 BRAF NGF MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis NTN3 CDH4 BNIP2 CTNNA2 NEO1 SPAG9 MYOG MEF2B MYOD1 TCF12 MYF6 TCF4 CDH15 MYF5 CDH2 MEF2A CTNNB1 MEF2D CDON CTNNA1 MEF2C ABL1 TCF3 CDC42 MAPK14 MAPK12 MAP2K6 MAPK11 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation RPS6KA3 RPS6KA5 RPS6KA2 MAPKAPK2 RPS6KA1 ATF1 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 TGFA LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN FGF10 EGF AREG FGF2 FGF4 LAMA5 PRL FGF7 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 ITGA2B CBX6 PHC2 GATA3 PHC1 H2AX CBX4 GATA2 CBX2 GATA1 ASH2L SMARCB1 PHC3 LGALS3 CTLA4 BMI1 H3-3B SMARCC1 SMARCC2 H3C8 RING1 H2AJ SRC YAP1 RNF2 H3C15 CCND3 CCND2 CCND1 H2BC9 H2BC8 H2BC5 ABL1 H2BC3 SMARCA2 SMARCA4 CDK6 H2BC1 TP73 ACTL6B ACTL6A CTSV H2AB1 CTSL CTSK H2AC8 H2AC6 H2AC7 PBRM1 PRKCQ KMT2A KMT2C SERPINB13 GPAM SMARCD3 SIN3B ARID2 DPY30 SIN3A H2BC26 H2BC21 WDR5 CR1 EP300 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SMARCD1 CREBBP AUTS2 SMARCD2 IL2 H2BC11 IL3 TCF3 LDB1 PSMD8 RBBP5 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMARCE1 H2AZ2 PTPN11 PML TNRC6C PRKCB NFATC2 PSMA5 TNRC6A PSMA6 ITCH TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXP3 PSMD13 MYB BLK ZFPM1 ELF1 PSMA7 ELF2 CBFB PAX5 PSMB6 RUNX1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 PRMT6 RPS27A KMT2D ADRM1 SEM1 PRMT1 GP1BA PSMC5 PSMC6 PSMC3 KMT2B PSMC4 PSMC1 PSMC2 NFE2 HDAC1 SOCS3 LMO1 LMO2 TJP1 SETD1B OCLN LIFR SETD1A KCTD6 CCNH ESR1 SOCS4 NR4A3 RSPO3 CDK7 TCF12 AXIN1 MNAT1 KAT2B ARID1A ARID1B TAL1 H2AC19 H2AC14 IFNG H2BC12L THBS1 YAF2 CSNK2A1 CSNK2A2 CSNK2B TNFRSF18 SPI1 PCGF5 HIPK2 CLDN5 H4C9 RYBP MOV10 AGO3 PF4 AGO4 MYL9 H2AC20 AGO1 CSF2 AGO2 IL2RA CBX8 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization EZH2 H2AX CDH4 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B CLDN2 H3C8 MTBP ZC3H12A CSNK2A3 CLDN6 H2AJ CLDN4 CLDN3 SRC CLDN9 CTNND1 CLDN8 CLDN7 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 CLDN22 CLDN20 ZMYM2 CLDN23 RACK1 CLDN11 CLDN10 CLDN15 CLDN14 SUZ12 CLDN12 H2BC9 CLDN19 H2BC8 CLDN18 H2BC5 CLDN17 CLDN16 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST SDK1 H2AC8 SDK2 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 PARD6G PARD6B MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 PATJ F11R PALS1 ZEB1 CRB3 PARD6A PARD3 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 RBBP7 H2AZ2 TGIF2 TNRC6C DOCK1 TNRC6A TNRC6B ARHGEF4 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 VAV2 PRDM8 BHLHE22 KDM1A CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 CLDN5 SNAI1 ZNF217 FURIN PCSK6 ANK3 TYK2 RB1 POMT2 DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PRKCI PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CLDN1 RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 JAK2 H4C9 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex TAB3 TAB2 TAB1 UBA52 IRAK2 TICAM2 TICAM1 TLR4 LY96 UBB TRAF6 CD14 UBC RPS27A MAP3K7 INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling HLA-DRB3 HLA-DRB1 UBE2E1 JAK1 HLA-A B2M HLA-DPA1 CDK1 HLA-DQB2 HLA-DQB1 PSMB8 IFNB1 STAT1 STAT3 MAPK1 MAPK3 HLA-DPB1 PLCG1 IRF3 NPM1 IFITM3 IFITM1 IFITM2 IFIT5 IFI35 IFIT1 HLA-DRA IFI30 IFIT3 IFIT2 ICAM1 TRIM29 TRIM26 TRIM22 FAAP100 GBP5 GBP7 RSAD2 IFI27 TRIM17 PDE12 UBE2N TRIM14 ATF6 TRIM10 EGR1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 RNASEL IFI6 FAAP24 IRF1 FAAP20 PGGT1B FLNB HSPA1L IFI44L ILF2 MID1 IP6K2 MT2A VCAM1 FANCM FANCL FANCA HSPA2 FANCB FANCE FANCG PTPN11 FANCF ISG20 XAF1 FCGR1BP PTPN6 CIITA ADAR EIF2S3 OASL TRIM68 TRIM62 EIF2S2 OAS1 EIF2S1 OAS3 IRF8 IRF6 EIF4E2 IRF9 BECN1 SAMHD1 TRIM46 TRIM48 GBP3 SNCA TRIM45 MX2 MX1 TRIM35 TRIM38 CENPX TRIM31 TRIM34 ACTB IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 TRIM25 DUS2 IFNA21 IFNA14 GBP6 IFNA16 IFNA17 MAVS TP53 IFNA10 RIGI FLNA SPHK1 ACTG1 PIM1 NCK1 BST2 ILF3 FCGR1A ARIH1 NUP205 POM121 NUP188 FNTA FNTB AAAS POM121C NUP42 IFNAR1 NUP62 FURIN TPR CD44 NUP88 RAE1 KPNA1 NUP214 SFN NDC1 NUP210 NUP155 IFNGR1 IFNGR2 NUP153 NUP93 TYK2 NUP50 NUP35 NUP54 STAT2 EIF4E EIF4G1 FKBP5 HSPA1B NCAM1 KPNA7 KPNA4 KPNA5 NUP107 EIF4G3 KPNA2 HSPA8 EIF4G2 KPNA3 EIF4E3 PPP2R1B FANCC PPP2R1A NUP160 KPNB1 HLA-H HLA-C HLA-F NUP85 HLA-G HLA-E EIF2AK2 ISG15 SEC13 CASP1 NUP133 PPP2R5A IRF2 DNAJC3 OAS2 IKBKB GBP2 GBP4 IKBKG PML UBE2L6 PPP2CA CHUK HERC5 PPP2CB NUP43 GBP1 RANBP2 TRIM21 UBA52 ABCE1 HSPA1A HLA-B UBB UBC CENPS RPS27A NUP37 IRF5 EIF4A2 EIF4A1 SOCS3 HSPA5 EIF4A3 USP18 SP100 UBE2I PIAS1 PTAFR NEDD4 SUMO1 SMAD7 PTPN2 PRKCD YBX1 IRF4 PIN1 CAMK2B CAMK2D CAMK2A IFNG PPM1B EIF2AK3 CAMK2G UBA7 PRKRA TARBP2 SOCS1 JAK2 HLA-DQA2 HLA-DRB5 IRF7 HLA-DRB4 DHX9 RAF1 PTPN1 MAP2K6 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 TNPO1 ANAPC2 XPO1 ANKLE2 PTTG1 EMD LEMD3 RCC1 LMNB1 SPAST CC2D1B SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 TUBB6 TUBB3 TUBB1 TUBA4B PPP2R2A TUBA4A TUBA8 TUBA1C TUBA1B TUBA1A FBXO5 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 NUP62 BANF1 NDC1 NUP155 NUP93 NUP35 NUP54 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 KPNB1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 LBR KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 CHMP4A BIRC5 PSMD8 KIF2C CHMP6 KIF2B CHMP7 PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CHMP2B CLASP1 PSMA4 DYNC1I1 CHMP2A PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 RAN NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2I SUMO1 VPS4A TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs RAB7A TBC1D20 TSC2 TSC1 RAB5B MAP1LC3B RAB5C RAB11A RAB5A RAB6A OPTN RAB6B RAB8A RABGAP1 GABARAP GGA2 RABGEF1 GGA1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B ARF6 TBC1D2 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC PLA2G3 PLA2G4B PLA2G6 PLA2G2A PLB1 PLA2G4F TMEM86B PLA2G4E LPCAT4 PNPLA8 PLA2G10 PLA2G4C MBOAT2 PLAAT3 PLA2R1 LPCAT3 LPCAT2 PLBD1 PLA2G4A PLA2G1B LPCAT1 PLA2G5 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism PGK1 ENO1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity UACA MAPK1 APIP MAPK3 CYCS XIAP CASP9 AVEN DIABLO APAF1 CARD8 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling CASP8 FAS FASLG CASP10 FADD RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 GTF3C2 GTF3C3 CRCP GTF3C4 GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade SOS1 THEM4 IGF1R KLB IRS1 PDE3B AKT2 PIK3R4 IRS4 IRS2 IGF2 FGF1 IGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) LEUTX TPRXL DPPA4 EP300 TPRX2 DPPA2 ZSCAN4 DUXA DUXB TP53 CREBBP TEAD4 TUT7 KDM4E YAP1 TUT4 TPRX1 DUX4 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors HRH1 HRH3 HRH2 HRH4 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 FGFR3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 SEL1L PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 SYVN1 SHH ERLEC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA CNOT4 CNOT6 PARN CNOT7 TNKS1BP1 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B TUT7 PABPC1 TUT4 EIF4G1 EIF4A2 EIF4A1 PAIP1 PAN2 PAN3 CNOT10 EIF4A3 CNOT11 CNOT6L SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors APOB CD36 PRDX1 SAA1 S100A9 CD5L APOA1 SSC5D HMGB1 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition MCM6 MCM2 CCNB1 CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 CDKN1C RB1 CDKN2D CDKN1A CDKN2B CDKN1B CDKN2C CCND3 CDKN2A CCND2 CCND1 E2F1 E2F2 ABL1 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 CDC6 PPP2R1B PPP2R1A PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 MYBL2 PSMD1 SKP1 PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 RRM2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 MCM10 MAX PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PTK6 PSMC1 RPA4 TOP2A LIN54 PSMC2 CKS1B LIN52 LIN37 HDAC1 LIN9 CABLES1 WEE1 CDC7 CCNH PPP2R2A CDK7 MNAT1 POLE RBL2 RBL1 AKT2 MYC AKT3 AKT1 FBXO5 PCNA JAK2 DYRK1A LYN DHFR E2F4 TK1 TYMS E2F5 PPP2R3B E2F6 RPA1 RPA2 CDC45 POLE4 MCM7 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux TNRC6A TNRC6B RXRB NCOR2 HDAC3 GPS2 ABCG1 CETP EP300 KDM4A TBL1X NCOA1 KDM1A ABCA1 APOC4 NR1H3 APOE NCOR1 APOC2 NR1H2 TBL1XR1 APOC1 KDM3A KDM1B APOD ARL4C EEPD1 MOV10 AGO3 AGO4 RXRA AGO1 ABCG8 AGO2 ABCG5 TNRC6C GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding CXCL8 C5AR2 C5AR1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 C3 C5 ADRA1D ADRA1B ADRA1A TBXA2R OPN1MW CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P HRH1 HTR6 C3AR1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 GPR143 ADRB3 CYSLTR1 CYSLTR2 ADORA2B S1PR1 GABBR2 GABBR1 RHO SAA1 MCHR1 SST CCL2 SSTR3 OPN1SW CCR5 APP MC4R EDNRB EDN1 EDN3 GLP1R UCN VIPR1 MC3R VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP ADGRE2 POMC SHH GNGT2 MC1R ADGRE5 UCN3 UCN2 MC5R ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP ADCYAP1 SMO CRH IAPP ADCYAP1R1 CGA RAMP2 CALCA TSHB RAMP3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 CX3CR1 PTHLH CRHR1 GHRHR WNT6 GNG10 GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 CXCR4 WNT2 CD55 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 FZD4 CXCL12 WNT3A PTCH1 FZD7 GCGR WNT7B FZD6 PTCH2 FZD9 SCTR FZD8 WNT7A GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH MRGPRD GNB1 CMKLR1 PF4 GNAS PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 VIP GALR3 RAMP1 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 CCL19 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 ECE1 ECE2 ANXA1 PRLHR ADORA2A CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN TAS2R20 RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 KEL TAS2R40 TAS2R41 TAS2R42 TAS2R43 LHB TAS2R45 TAS2R46 NLN MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP ADRA2C TAS2R38 ADRA2B TAS2R39 ADRA2A TAS2R60 PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 TAS2R9 CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 GRM3 GRPR GRM2 EDNRA GRM4 PROK2 GRM7 PROK1 GRM6 UTS2R GPER1 NPFF GRM8 TRHR TAS2R1 UTS2B TAS2R3 AGTR1 TAS2R5 PTGFR TAS2R4 LPAR1 PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR TAS1R2 LPAR5 S1PR3 LPAR6 TAS1R1 NMS S1PR2 NMU S1PR5 GNRH2 TAS1R3 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY ACKR4 AVPR2 BRS3 ACKR3 GPRC6A OXT ACKR2 GPR132 AVP ACKR1 CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR OPRM1 CASR F2R LTB4R2 UTS2 NTS KNG1 MCHR2 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R GRM1 OPRK1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 P2RY6 P2RY2 P2RY1 CCK HCRTR2 HCRTR1 KISS1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus MAPK8 UBA52 NGFR SQSTM1 UBB TRAF6 ITGB3BP PSENEN PSEN2 PSEN1 UBC NGF APH1A NCSTN RPS27A APH1B REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins EZH2 FURIN H2AX PCSK6 ANK3 MDM2 H3-3B H3C8 MTBP CSNK2A3 H2AJ SRC CTNND1 CDH1 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RB1 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 MAPK3 FOXQ1 H2AB1 TLE1 ZBTB33 POMT2 CTSL H2AC8 H2AC6 PKM H2AC7 DNM2 MYCN TMEM258 POMT1 SEC11A KLF9 MCRIP1 SEC11C FOXJ2 STRAP FOXP2 OST4 SP1 OSTC STT3A ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 SPCS3 H2BC13 SPCS2 H2BC14 SPCS1 H2BC15 DAD1 HDAC2 H2BC11 JUP SIRT1 TCF3 PSMD8 RBBP4 CANX PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 PSMD1 H2AZ2 KMT5A TGIF2 KLF4 TNRC6C PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 PSMA7 TWIST2 TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC ARHGAP32 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 KDM1A CTNNA1 H4C9 SNAI1 VCL MOV10 AGO3 AGO4 H2AC20 AGO1 ZNF217 AGO2 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane PDCD1 TMEM258 CD274 RPN2 DDOST RPN1 MAGT1 DAD1 OST4 JAK1 OSTC MIB2 STT3A STT3B PDCD1LG2 TUSC3 B3GNT3 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation GNA14 GNGT1 GNA15 OPRM1 POMC GNA11 GNAQ GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 PDYN GNB4 GNB3 GNB5 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation GUSB CD44 SPAM1 STAB2 CEMIP HYAL2 SLC9A1 SLC17A5 HMMR HEXB HEXA LYVE1 HYAL1 HYAL3 CHP1 HYAL4 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants FLT3 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis HS3ST6 HS3ST4 HS6ST2 HS3ST1 HS6ST3 HS3ST2 NDST2 NDST1 NDST4 NDST3 GLCE EXTL2 GPC1 HSPG2 GPC3 HS3ST3A1 GPC2 SDC4 SDC2 HS2ST1 GPC5 SDC3 GPC4 SLC35D2 EXTL3 GPC6 AGRN HS3ST3B1 EXT1 EXT2 SDC1 HS6ST1 HS3ST5 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms MAPK8 CYBA DVL1 DVL2 NOXO1 NOXA1 DVL3 WNT5A JUN FZD7 NOX1 RAC1 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 FGF9 FGF20 FGF23 FGF22 SOS1 FGF10 NRAS HRAS FGF1 FGF2 FGF3 FGF4 FGF6 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation SEC22B HLA-A B2M ITGB5 PSME1 PSME2 PSMB10 PSMB8 PSMB9 CTSV CTSL VAMP8 HLA-H HLA-C HLA-F LY96 HLA-G HLA-E HMGB1 NCF1 TLR1 NCF2 NCF4 CALR SNAP23 TLR6 TLR2 PDIA3 CYBB CYBA PSMD8 IKBKB TLR4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG CHUK FCGR1BP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 VAMP3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 HLA-B MYD88 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB CD14 PSMB2 PSMB3 UBC PSMB1 RPS27A LNPEP ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MRC1 TAP2 S100A9 TAP1 S100A8 CD207 SEC61A2 MRC2 SEC61A1 SEC61G SEC61B TAPBP STX4 BTK S100A1 CD36 ITGAV TIRAP CTSS FGB FGA FGG FCGR1A DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound KCNMB1 KCNMA1 CHRNA10 KCNN2 EZR SPTBN1 RDX MSN CLIC5 RIPOR2 SNAP25 CIB2 PJVK ESPN EPS8 SPTAN1 PLS1 TPRN TMC1 VAMP2 MYO7A STX1A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 PCLO USH1C CAPZB ESPNL BSN EPB41L3 SYP OTOG CABP2 CDH23 CACNA1D XIRP2 CABP1 EPS8L2 LRRC52 MPP1 OTOF GRXCR1 CASK SLC17A8 GRXCR2 GSN CAPZA1 WHRN CAPZA2 LHFPL5 OTOGL TMIE USH1G STRC EPB41L1 MYO15A SLC26A5 CACNA2D2 CHRNA9 SYN1 RAB3A TWF1 MYH9 CACNB2 ATP2B1 DNAJC5 MYO1C SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 TIMP2 TIMP1 RARA HELLS MYCN TGFB2 TNRC6A INHBA TNRC6B TGFBR1 KLF16 ACVR2A TGFBR2 TGFBR3 MMP14 MMP16 GIPC1 MYOG INHA MYOD1 TCF12 MYF6 TCF4 SP1 MYF5 PSENEN TGFB1 PSEN2 PSEN1 FGF2 APH1A NCSTN APH1B EP300 ARRB1 ARRB2 TCF3 MOV10 SMAD4 AGO3 SMAD3 AGO4 RXRA AGO1 AGO2 TNRC6C PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism KYAT1 ASRGL1 QDPR IL4I1 PAH PCBD1 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs PPP1CC FURIN SMAD7 TGFB2 FKBP1A TGFBR1 UBE2M TGFBR2 ITGAV TGFBR3 UBA52 STRAP STUB1 PPP1R15A USP15 LTBP4 LTBP2 LTBP3 MTMR4 LTBP1 UBB ITGB8 TGFB1 PMEPA1 UBC ITGB6 TGFB3 XPO1 RPS27A UCHL5 ITGB5 CBL BAMBI ITGA8 ITGB1 ITGB3 NEDD4L PPP1CB NEDD8 PPP1CA SMAD2 SMAD4 SMAD3 SMURF2 SMURF1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling USP8 AKT2 UBB AKT3 UBA52 ERBB2 UBC AKT1 RNF41 NRG1 NRG2 RPS27A CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly MTTP APOA2 APOC2 APOA4 APOB P4HB SAR1B APOA1 APOE APOC3 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression SAP30 H2AX SUDS3 DNMT3B DNMT1 SAP30L H3-3B TBP SAP18 H3C8 H2AJ H3C15 HDAC1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CCNH MBD2 H2AB1 POLR2E POLR2F H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AC19 H2AC14 H2BC12L SIN3B SMARCA5 SIN3A H2BC26 H2BC21 TTF1 SAP130 UBTF SAP30BP H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 BAZ2A POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 H2AZ2 ARID4B H2AC20 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation BMP1 LAMB3 TLL2 TLL1 LAMA3 LAMC2 COL7A1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants ALK DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant VWF ADAMTS13 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC4 GALNT1 ST3GAL1 ST6GALNAC2 ST3GAL2 ST3GAL3 ST6GAL1 ST3GAL4 ST6GALNAC3 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes CDKN1A TP53 ZNF385A PCBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress BAG5 POM121C HSPH1 NUP42 ATM NUP62 DNAJB6 NUP43 BAG3 TPR ATR HSF1 BAG1 NUP88 YWHAE RAE1 HSPA4 ST13 RPTOR NUP214 RANBP2 HSPA7 NDC1 HSPA6 NUP210 HSPA12A NUP155 HSPA12B NUP153 HSPA1A NUP93 NUP50 NUP35 NUP54 AKT1S1 NUP37 HSPA9 HSPA5 HSPA1B MAPK1 MAPK3 BAG2 NUP107 EEF1A1 HSPA8 MAPKAPK2 VCP CAMK2B CAMK2D CAMK2A NUP160 NUP85 GSK3B HSP90AB1 CAMK2G MLST8 EP300 SEC13 NUP133 CREBBP FKBP4 HSP90AA1 SIRT1 HSPA1L HDAC6 HSPB8 HIKESHI CCAR2 HSBP1 RPA1 DNAJC2 RPA2 DNAJC7 CRYAB RPS19BP1 PTGES3 HSPA2 NUP205 HSPA4L POM121 HSPA14 RPA3 NUP188 HSPA13 DNAJB1 MTOR AAAS BAG4 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER SUMO2 GTF2H1 ERCC4 GTF2H2 ERCC1 ERCC5 CETN2 GTF2H3 UBA52 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RNF111 UBB UBC RPS27A UBE2V2 UBE2N RBX1 PIAS3 UBE2I PARP1 PARP2 USP45 RAD23A CHD1L CUL4A CCNH RPA1 DDB1 RPA2 RAD23B PIAS1 CUL4B XPA RPA3 DDB2 SUMO1 XPC SUMO3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death CASP8 TICAM2 TICAM1 TLR4 LY96 CD14 RIPK3 RIPK1 FADD PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors PRKACA PRKACG PFKFB1 PRKACB MLXIPL DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism UBE2L6 POM121C HERC5 NUP42 NUP62 NUP43 TPR NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 UBA52 NUP210 UBE2E1 EIF4E2 NUP155 BECN1 NUP153 NUP93 NUP50 JAK1 NUP35 NUP54 MX2 MX1 UBB EIF4E UBC RPS27A NUP37 EIF4G1 EIF4A2 EIF4A1 EIF4A3 USP18 STAT1 MAPK3 PLCG1 KPNA7 KPNA4 KPNA5 NEDD4 NUP107 EIF4G3 KPNA2 EIF4G2 EIF4E3 KPNA3 TRIM25 IRF3 RIGI PIN1 NUP160 IFIT1 KPNB1 NUP85 PPM1B EIF2AK2 ISG15 UBA7 UBE2N SEC13 NUP133 FLNB ARIH1 NUP205 POM121 NUP188 AAAS P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events MAPKAPK3 HRAS MAPKAPK2 RALGDS RALA RALB MAPK14 MAPK12 MAPK13 MAPK11 NRAS TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F2 F12 SERPING1 KLKB1 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation MGST1 MGST2 GGT3P GSTM1 GSTO1 GSTT2 GSTT1 OPLAH CNDP2 GSTA2 HPGDS ESD GSTA1 CHAC2 CHAC1 GSTT2B GSTM4 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT GSS GSTA5 GSTA4 GGT1 GSTM5 GSTK1 GSTP1 GGT5 GSTA3 GCLC GCLM AKR1A1 GGT7 GGT6 MGST3 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria ASL RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription H2AX MTA2 H3-3B TBP H3C8 H2AJ RRN3 ERCC6 H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 MAPK3 CCNH MBD2 H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 KAT2B MNAT1 KAT2A H2AC19 H2AC14 H2BC12L MBD3 H2BC26 H2BC21 TTF1 GATAD2B UBTF GATAD2A H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 EHMT2 POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A CAVIN1 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly ABCB7 CIAO3 NUBP1 NUBP2 RTEL1 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B BRIP1 POLD1 ERCC2 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions ERLIN2 FGFR1 BAG4 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGF9 FGF20 FGF23 FGF16 FGF18 FGFR3 FGF1 FGF2 FGF4 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNAI3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 GNAT3 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 ADCY9 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 IMP4 SNU13 RRP7A PDCD11 ERI1 GAR1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 CSNK1E RRP36 UTP6 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL MTREX RPP38 DIMT1 FTSJ3 EBNA1BP2 DKC1 NHP2 RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 NOP10 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 SENP3 UTP18 C1D DDX21 BMS1 RPP14 DCAF13 KRR1 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 XRN2 NCL NOP56 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 TRMT112 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A NOP2 NOP58 CSNK1D GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade PTPN6 PDPN PLCG2 MPIG6B FCER1G GP6 VAV3 SYK RAC1 VAV2 PRKCZ VAV1 RHOA PIK3CB PIK3CG PDPK1 RHOB CLEC1B PIK3R3 PIK3R2 RAC2 PIK3R1 PIK3CA PIK3R6 LCK PIK3R5 LYN CDC42 FYN RHOG LCP2 LAT PTPN11 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling TIMP1 CXCL1 CCR5 CXCL2 CSF3 IL1RN TNF IL12B IL12A IL10RB IL1R2 IL10RA CSF1 CCR1 LIF IL6 TYK2 TNFRSF1B JAK1 TNFRSF1A CXCL8 FCER2 CCL19 ICAM1 CCL22 CCL20 IL10 CCR2 PTGS2 CXCL10 IL18 IL1A IL1B STAT3 CCL5 CCL4 CCL3 CD86 CCL3L3 CD80 PTAFR FPR1 CSF2 CCL2 IL1R1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis LTF GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 NFE2L2 PSMD3 PSMD1 BTRC SKP1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation SERPINA1 SOD1 FN1 F5 F8 RAC1 VAV1 SRC SHC1 RAP1A MAPK1 MAPK3 EGF MAPK14 CLU SERPING1 TF DGKG DGKE DAGLA DGKD DGKB DGKA PRKCQ ABHD6 SOS1 ABHD12 CRK PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI RASGRP2 DGKH VEGFA HGF PRKCZ RHOA PIK3CB PIK3CG RHOB PDPK1 CLEC1B PIK3CA LCK APOA1 LAMP2 CDC42 PCDH7 FYN CSK RHOG PPIA RASGRP1 PTPN11 PTPN6 PDPN MPIG6B CALM1 FCER1G GP6 APP SERPINE1 GNA13 TBXA2R GNA12 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 CD109 TAGLN2 NHLRC2 STXBP3 TEX264 STXBP2 PDGFB ENDOD1 A1BG YWHAZ APOH VTI1B RAB27B MANF A2M CALU MAGED2 HRG RAC2 FERMT3 SERPINA3 ORM1 ECM1 GNGT1 OLA1 CTSW ORM2 SERPINA4 GNGT2 TMSB4X TIMP3 QSOX1 ALB AHSG ANXA5 RAPGEF3 RAPGEF4 TOR4A GNAT3 CD63 SPP2 LEFTY2 LY6G6F MGLL VEGFB VEGFC VEGFD LHFPL2 PCYOX1L PLCG2 MPL F13A1 POTEKP TUBA4A VAV3 CFL1 FAM3C ABCC4 APLP2 PTK2 SYK TMX3 GNAI3 SELENOP SCG3 THPO GP9 RARRES2 PFN1 GP1BB VAV2 CYRIB FLNA SELP GP5 SCCPDH ACTN2 GNAQ LGALS3BP GNG10 WDR1 PLEK GNG3 GNAI1 PHACTR2 CYB5R1 SRGN GNG2 GNAI2 MMRN1 PECAM1 GNG5 CAP1 ITIH4 GNG4 IGF2 ITIH3 GNG7 IGF1 PLG GNG8 TTN CLEC3B CDC37L1 AAMP BCAR1 ACTN1 GNA14 GNA15 GNA11 GNG12 GNG11 GNG13 GNB2 GNB1 PF4 GNB4 GNB3 GNB5 ITGA2B ALDOA P2RY12 PSAP CD9 PRKCG PPBP ADRA2C ADRA2B ADRA2A TGFB1 PRKCB GP1BA APOOL PROS1 HSPA5 GAS6 STX4 F2 TIMP1 TGFB2 BRPF3 CD36 F2RL2 F2RL3 PRKCD PRKCA PLA2G4A F2R ITPR1 ITPR2 KNG1 ITPR3 THBS1 AKT1 TGFB3 CFD ITGB3 PIK3R3 ARRB1 PIK3R2 PIK3R1 ARRB2 RAP1B PIK3R6 PIK3R5 FGB TRPC7 FGA LYN TRPC6 VWF P2RY1 TRPC3 FGG APBB1IP RAF1 TLN1 PTPN1 VCL LCP2 LAT GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis B3GALT6 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN GPC6 DCN BCAN VCAN AGRN CSPG5 CSPG4 PXYLP1 SDC1 B4GALT7 UXS1 XYLT2 B3GAT3 XYLT1 FAM20B B3GAT2 B3GAT1 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases TFPT MCRS1 INO80 PSMA5 PSMA6 TGFBR1 PSMA3 TGFBR2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 OGT PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEDD8 ACTB ACTL6A H2AC8 H2AC6 H2AC7 SMAD7 H2AC17 H2AC12 H2AC1 USP15 H2AC19 H2AC25 H2AC14 H2AC21 TGFB1 UCHL5 BAP1 UCHL1 SENP8 UCHL3 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 RUVBL1 NFRKB ACTR5 BARD1 KDM1B PSMD8 ACTR8 YY1 PSMD6 PSMD7 INO80C PSMD2 INO80B PSMD3 INO80E PSMD1 INO80D H2AC20 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors GRIK1 GRIK2 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions PAOX MAOA MAOB SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants SOS1 EREG PIK3R1 BTC PIK3CA SHC1 NRG2 HBEGF NRG3 EGFR NRG4 NRAS HSP90AA1 GAB1 CDC37 HRAS ERBIN PLCG1 EGF ERBB2 NRG1 CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA PTPN6 BTLA TNFRSF14 PTPN11 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly H2AC6 H2AC7 H2AX H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 ADNP2 H2BC9 ADNP H2BC8 H2BC5 H2BC11 H2BC3 CBX1 H2BC1 H4C9 CHD4 H2AB1 H2AZ2 H2AC20 CBX3 H2AC8 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle CPD PKP4 PLEKHG5 EPHA2 RASAL2 MUC13 TFRC VANGL1 FLOT2 PIK3R2 PIK3R1 GRB7 DSP TXNL1 STMN2 ARHGAP5 KIF14 ARHGAP35 RND1 STIP1 FRS3 EPSTI1 WDR6 PLXNA1 FAM83B RBMX ANKRD26 DST KIDINS220 CAV1 RRAS2 FRS2 ALDH3A2 TMEM59 PTPN13 CCDC88A LEMD3 FAM135A VANGL2 DEPDC1B UBXN11 DLG5 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling CAP2 ROBO1 ABL2 CLASP1 CLASP2 CAP1 ABL1 SLIT2 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants PDGFRA TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding NECAP1 CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 CHMP2A APP SNX2 BLOC1S3 SNX5 NAPA TBC1D8B SNAPIN AP1G1 SORT1 DTNBP1 AP1S2 PUM1 AP1B1 TPD52L1 AP1S1 GOLGB1 AP1S3 YIPF6 TGOLN2 ACBD3 TFRC AP1M2 AP1M1 FTH1 IGF2R HGS CLINT1 SH3GL2 FTL VAMP2 ARF1 STX4 CTSZ AP4E1 CLTB AP4M1 AP1G2 BLOC1S1 CLVS2 AP4S1 CLVS1 AP3B1 TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 RAB5C GBF1 GNS SNX9 SNAP23 ARRB1 CLTC PICALM CLTA PIK3C2A OCRL GAK HIP1R CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins CASP3 CASP8 CASP7 VIM DBNL GAS2 MAPT ADD1 SPTAN1 PLEC CASP6 GSN LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis NRIP1 RXRB RXRA NR1H3 PCK1 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) DNAJB11 EIF2S3 DIS3 PARN EIF2S2 CREB3L3 EXOSC7 SULT1A3 EIF2S1 EXOSC6 EXOSC5 EXTL2 EXOSC4 EXOSC9 KHSRP IGFBP1 EXOSC8 PREB EXOSC3 EXOSC2 CXCL8 EXOSC1 EXTL3 GOSR2 ADD1 FKBP14 HERPUD1 MYDGF TATDN2 SERP1 CEBPB SEC31A CREB3L4 GFPT1 CREB3L1 CREB3L2 TSPYL2 DDX11 WIPI1 PDIA6 PDIA5 ATP6V0D1 ERN1 CREB3 DCSTAMP CTDSP2 KDELR3 ATF6B SHC1 HSPA5 DCTN1 CEBPG CXXC1 EXTL1 SSR1 DNAJB9 ZBTB17 KLHDC3 WFS1 EDEM1 ASNS YIF1A CREBRF SRPRA ACADVL SRPRB TPP1 HDGF GSK3A PLA2G4B LMNA MBTPS1 NFYA HYOU1 NFYB NFYC MBTPS2 EIF2AK3 HSP90B1 DCP2 CUL7 ATF4 ATF6 ATF3 CALR PPP2R5B SYVN1 ARFGAP1 DNAJC3 DDIT3 TLN1 CCL2 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production DPEP2 DPEP1 GGT5 CYSLTR1 CYSLTR2 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 CDC25B PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 MAX PSMC5 PSMC6 PSMC3 PSMC4 RB1 PTK6 PSMC1 LIN54 CDKN1A PSMC2 CDKN1B CKS1B LIN52 LIN37 FZR1 LIN9 CCND1 CABLES1 E2F1 WEE1 SKP2 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 CDK7 MNAT1 RBL2 AKT2 MYC AKT3 AKT1 E2F4 E2F5 PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters SLC35C1 POM121C NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 SLC17A5 NUP35 NUP54 SLC40A1 HEPH SLC35A1 DERL3 DERL1 DERL2 SLC11A2 OS9 SLC26A2 SLC34A3 SLC34A2 SLC34A1 NUP107 GCKR CP ABCA12 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 ABCB6 VCP ABCB4 SLC5A2 SLCO1B1 SEL1L SLCO1B3 SLC33A1 SLC6A5 SLC9A6 SLC26A4 SLC26A3 ABCD4 SLC9A9 SLC6A2 SLC12A3 GCK SLC22A12 SLC2A1 SLC2A10 ABCC6 SLC12A1 SLC12A6 NUP160 LMBRD1 SLC29A3 HK1 SLC24A4 RNF185 SLC20A2 ABCB11 NUP85 SLC35A2 SLC16A1 SLC24A5 ABCC8 SEC13 NUP133 ABCC2 APOA1 RNF5 ERLEC1 PSMD8 CFTR PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 NUP43 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 RANBP2 UBA52 PSMD12 PSMD11 SLC22A5 PSMD14 PSMD13 SLC35A3 SLC1A1 SLC2A9 PSMA7 SLC24A1 SLC3A1 PSMB6 SLC1A3 SLC2A2 PSMB7 SLC5A1 PSMB4 SLC3A2 PSMB5 UBB SLC6A3 PSMB2 PSMB3 SLC5A7 SLC6A20 UBC PSMB1 ABCD1 RPS27A NUP37 ADRM1 SEM1 SLC67A1 PSMC5 PSMC6 PSMC3 PSMC4 AVPR1B PSMC1 SLC6A19 AVPR2 PSMC2 SLC36A2 AVP AVPR1A SLC6A14 ABCA1 SLC7A7 SLC7A9 SLC5A5 SLC17A8 ABCG8 ABCG5 ABCC9 ABCA3 SLC4A1 RHAG KCNJ11 ERLIN1 ERLIN2 NUP205 POM121 NUP188 AAAS U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing DDX42 DDX23 NCBP1 NCBP2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 TXNL4A POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G SRSF2 POLR2H POLR2I POLR2J POLR2K SRSF6 POLR2L SRSF7 GTF2F1 GTF2F2 SRSF1 SNRNP40 YBX1 SNRPD2 SNRPD1 SNRPD3 SNRPG ZCRB1 SNRPE SNRNP200 PDCD7 SNRPF SNRNP35 SNRNP25 SNRPB RNPC3 ZMAT5 ZRSR2 SNRNP48 EFTUD2 PRPF6 PRPF8 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins DEFB108C DEFB130A DEFB130B DEFB4B CCR6 CCR2 DEFB103B TLR1 DEFB105B DEFB129 DEFB128 DEFB131A TLR2 DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis DOLK PMM2 DHDDS MPI DPM1 DPM2 DPM3 GALE GNE GALM GALK1 GALT NUS1 PGM1 SRD5A3 GFPT1 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 HSP90AA1 CDC37 ERBIN ERBB2 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage ALKBH2 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs FLT3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle PPFIA3 PPFIA2 SNAP25 SYT1 UNC13B VAMP2 CPLX1 STX1A SLC22A2 TSPOAP1 SLC22A1 SLC18A2 MAOA RAB3A RIMS1 PPFIA1 PPFIA4 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG5 B3GALT6 CSPG4 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN DCN GPC6 BCAN VCAN AGRN HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM7A PHF2 KDM5C KDM5B KDM3B KDM5D PHF8 UTY KDM2A KDM2B KDM4D ARID5B JMJD6 KDM6B H3C8 KDM4C H3C15 KDM4A KDM1A KDM5A RIOX2 KDM6A KDM3A H4C9 KDM1B KDM4B ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions LYN GBF1 NCL FURIN CLINT1 KDELR1 TSG101 YBX1 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling ARHGEF12 MYH9 RHOB RHOC MET MYL12B MYH11 RAC1 SEMA4D ARHGAP35 LIMK2 RND1 LIMK1 RRAS MYH14 MYH10 PLXNB1 MYL6 RHOA ERBB2 ROCK1 MYL9 ROCK2 ARHGEF11 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e DPM1 DPM2 DPM3 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates RRM2 NME2 NME1 GUK1 DTYMK AK1 AK2 AK4 GLRX AK5 AK6 AK7 AK8 AK9 NUDT13 RRM1 NME3 CTPS2 NME4 CTPS1 DCTD RRM2B NME6 CMPK1 DCTPP1 TYMS TXN TXNRD1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs RAD23A VCP RAD23B UBB PRKN ATXN3L UBA52 ATXN3 JOSD2 UBC JOSD1 RPS27A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis MOGAT3 MOGAT2 MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 GPAM LPIN1 LPIN2 LPIN3 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III TUBA4B TUBA4A CHMP2B CHMP2A TUBA8 TUBA1C TUBA1B SPAST TUBA1A CC2D1B TUBB8 IST1 LEMD2 TUBB8B TUBB2B TUBB2A TUBAL3 TUBA3E VPS4A TUBA3D TUBA3C CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 TUBB6 CHMP7 TUBB3 TUBB1 TUBB4B TUBB4A SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 TASL DUSP7 IRF5 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 SLC15A4 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR8 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MKKS MCHR1 TCP1 SSTR3 CCT8 BBS10 BBS9 CCT5 BBS2 CCT4 BBS1 TTC8 BBS12 BBS7 RAB3IP BBIP1 CCT3 LZTFL1 BBS5 CCT2 BBS4 SMO PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation NTRK1 IRS1 PIK3R2 IRS2 RHOA PIK3CA PIK3R1 PIK3CB NGF SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 ITCH HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 CNTN1 HEYL NOTCH1 RBX1 HDAC1 HEY1 DNER TLE4 TLE2 HDAC4 NUMB DTX1 HEY2 DTX2 DLK1 MIB2 SNW1 TLE1 JAG2 JAG1 CDK8 ADAM10 DTX4 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NBEA NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ ARRB1 HDAC5 ARRB2 HDAC2 HIF1A CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway CHUK TNF TNFRSF1A RBCK1 USP2 OPTN TRADD TAB3 TAB2 TAB1 RACK1 TRAF2 RNF31 TNFAIP3 SPATA2 OTUD7B IKBKB SHARPIN USP21 BIRC2 USP4 BIRC3 TRAF1 XIAP CYLD OTUD1 RIPK1 IKBKG MAP3K7 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion CHMP2B CHMP2A UBA52 UBB UBC RPS27A NEDD4L PDCD6IP TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C CHMP4C VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A CHMP6 UBAP1 CHMP7 VPS28 CHMP5 PPIA NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer PTPN6 GZMB RPS6 NPM1 IL10RA CCNB1 IRF4 DNMT1 CUL1 TWIST1 JUNB BCL2A1 CEBPB STAT5A RBX1 RB1 HDAC1 MAPK1 STAT3 MAPK3 MOV10 ZAP70 AGO3 AGO4 PRF1 FOXM1 AGO1 ICOS AGO2 SKP1 ZC3HC1 TNRC6C PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5C AGXT2 NT5C1A DPYS DPYD NT5M UPP2 NT5E UPP1 UPB1 TYMP THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor GNA14 GNGT1 GNA13 GNA15 TBXA2R GNA11 GNAQ GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 AAMP PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression EIF2S3 DIS3 PARN EIF2S2 EXOSC7 EIF2S1 EXOSC6 NFYA EXOSC5 NFYB EXOSC4 NFYC EXOSC9 KHSRP IGFBP1 EXOSC8 EXOSC3 EXOSC2 CXCL8 EXOSC1 HERPUD1 EIF2AK3 CEBPB DCP2 ATF4 ATF6 ATF3 HSPA5 CEBPG ASNS DDIT3 CCL2 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway ADH1A ALDH1A1 CRABP1 AKR1C3 DHRS3 ALDH1A3 CYP26A1 SDR16C5 CYP26B1 CYP26C1 DHRS9 RDH11 ALDH1A2 RDH10 RDH16 RDH5 RDH14 RDH13 DHRS4 ALDH8A1 ADH4 ADH1C SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling HRAS SOS1 EREG BTC SHC1 NRG1 NRG2 HBEGF NRG3 NRG4 NRAS ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport ABCG2 SLC22A3 ABCB1 SLC22A2 SLC22A1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest ARID3A CDKN1A CDKN1B TP53 ZNF385A PCBP4 E2F1 CCNE2 E2F7 E2F8 CCNE1 CDK2 CCNA2 CCNA1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes CACNA1H CACNB1 CACNB2 CACNB3 ITGB1 ITGB3 PIEZO1 ITGAV ITGA5 CACNA2D1 HSPG2 GJA1 SPP1 P2RX7 AKT1 PANX1 CACNG7 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis CD3G PLD4 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 PLD2 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 PRKCE IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 PLD1 IGKV5-2 IGKV1-5 IGLC6 AHCYL1 PLA2G6 PLCG2 SYK PRKCD ITPR1 ITPR2 ITPR3 IGHG3 IGHG4 IGHG1 IGHG2 PLPP5 PLPP4 PLD3 PIK3R2 PIK3R1 FCGR3A FCGR1A FCGR2A LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex IRAK2 TAB3 TAB2 TAB1 UBB TRAF6 UBA52 UBC RPS27A MAP3K7 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R1A BANF1 PPP2R2A ANKLE2 CCNB1 LMNB1 KPNB1 CDK1 CCNB2 EMD SIRT2 LEMD3 LBR VRK1 LEMD2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins YWHAE SFN TP53 BCL2L11 PPP1R13B TP53BP2 BID AKT2 YWHAH AKT3 BAD AKT1 YWHAG MAPK8 PPP3CC YWHAZ BMF BBC3 TP63 YWHAB E2F1 DYNLL1 DYNLL2 TFDP1 TFDP2 TP73 PMAIP1 BCL2 YWHAQ PPP3R1 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants FLT3 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN GRIN2B SRC NTRK2 RAC1 DOCK3 BDNF G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma GNG10 GNG3 GNG2 GNG5 AKT2 GNG4 GNG7 AKT3 RHOA GNG8 AKT1 PIK3CG PDPK1 PIK3R6 PIK3R5 GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling SOD1 MTAP IL12B IL12A SOD2 LMNB1 TYK2 JAK1 MSN PSME2 HNRNPF HSPA9 RALA PAK2 STAT1 STAT3 ARF1 P4HB IL6ST CAPZA1 VAMP7 SNRPA1 CFL1 ANXA2 GSTO1 TALDO1 GSTA2 IFNG CA1 IL10 TCP1 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF RPLP0 LCP1 RAP1B JAK2 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 CDC42 PDCD4 CRLF1 CANX HNRNPA2B1 PPIA DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 GALK1 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy UBE2N ARL13B HSF1 VCP UBE2V1 DYNC1I1 DYNC1LI1 DYNC1LI2 UBA52 DYNC1H1 DYNLL1 PCNT CETN1 HSP90AA1 PARK7 DYNLL2 HDAC6 CFTR UBB PRKN DYNC1I2 UBC IFT88 RPS27A FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation FGF22 TGFBR3 GIPC1 FGF1 FGF2 FGF10 FGF3 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling PTPN6 SOS1 IL2RG INPPL1 JAK3 INPP5D JAK1 PIK3CD PIK3CB GAB2 PIK3R3 PIK3R2 PIK3R1 PIK3CA SHC1 JAK2 IL2 IL3 IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CSF2 IL2RA VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism SLC2A1 GSTO2 GSTO1 SLC2A3 SLC23A2 CYB5A CYB5R3 SLC23A1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT GALNTL5 B3GNT3 GALNTL6 ST6GALNAC2 GALNT12 ST3GAL4 ST3GAL1 GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 C1GALT1C1 ST6GALNAC3 MUC12 ST6GALNAC4 MUC13 MUC15 MUCL1 MUC3A MUC5AC MUC3B B4GALT6 MUC1 B4GALT5 MUC2 MUC7 MUC4 MUC6 GALNT3 MUC16 MUC17 C1GALT1 MUC19 MUC5B B3GNT7 MUC20 B3GNT4 MUC21 B3GNT2 GALNT11 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport SLC8B1 PARL AKAP1 AFG3L2 PHB1 SLC8A3 SMDT1 VDAC3 VDAC2 YME1L1 PMPCB PMPCA MICU3 VDAC1 MICU2 MICU1 MCU LETM1 STOML2 MCUB SPG7 PHB2 MAIP1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane MTMR2 SACM1L PI4KA SBF1 PI4K2B ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein BID BAK1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors HSP90AA1 HSPH1 CALR APOB SCARF1 HYOU1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC4 GALNT1 ST3GAL1 ST6GALNAC2 ST3GAL2 ST3GAL3 ST6GAL1 ST3GAL4 ST6GALNAC3 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins FURIN EEF2 CALM1 HSP90AB1 STX1B SNAP25 SYT2 SV2C SYT1 SV2B SV2A PDCD6IP GUCY2C VAMP1 VAMP2 STX1A HBEGF HSP90AA1 MAP2K4 CD9 MAP2K1 MAP2K2 NHERF4 TXNRD1 MAP2K7 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels STIM1 TRPC7 ORAI2 ORAI1 TRPC6 TRPC3 ITPR1 P2RX6 ITPR2 P2RX5 P2RX7 P2RX3 ITPR3 P2RX4 P2RX2 P2RX1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB NDRG1 RABGGTA TP53I3 BCL6 PERP TP63 TP53 PPP1R13B BIRC5 TP53BP2 TP73 BCL2L14 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling ALOX5 IL18R1 IL37 IL4 IL18RAP IL18 IL13 IL18BP CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily H2AX MTA2 H3-3B H3C8 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 CHD5 H2BC3 IKZF1 UBE2I IKZF2 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 SUMO1 CBX3 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 G6PC1 H2AC19 H2AC14 H2BC12L NR2C2 MBD3 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 FBP1 H2BC15 ADNP2 HDAC2 ADNP H2BC11 CBX1 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2AX MTA2 ZNF610 ZNF324 ZNF680 TRIM28 ZNF320 ZNF264 H3-3B H3C8 ZNF317 ZNF30 H2AJ ZNF257 H3C15 ZNF708 ZNF354A MTA1 HDAC1 MTA3 H2BC9 ZNF141 H2BC8 H2BC5 ZNF382 ZNF547 H2BC3 UBE2I H2BC1 ZNF669 ZNF136 ZNF425 H2AB1 CBX5 H2AC8 SUMO2 H2AC6 ZNF765 H2AC7 ZNF93 ZNF816 ZNF534 ZNF418 ZNF778 H2AC19 H2AC14 H2BC12L ZNF224 ZNF649 ATF7IP MBD3 SETDB1 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 ZNF519 H2BC12 H2BC13 H2BC14 H2BC15 HDAC2 H2BC11 ZNF454 H4C9 ZNF33A CHD4 RBBP4 CHD3 RBBP7 H2AZ2 ZNF331 H2AC20 ZNF28 ZNF273 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling SOCS2 RAG2 RAG1 TSLP IL7 BRWD1 IL2RG CRLF2 JAK3 JAK1 H3C8 IRS1 HGF IRS2 STAT5A H3C15 STAT5B PIK3R3 PIK3R2 IL7R PIK3R1 SOCS1 STAT3 SMARCA4 CISH KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development GATA3 JAG1 DLL1 LFNG HNF1B FOXC2 FOXC1 SIX1 PCDH19 HOXD11 SLIT2 HOXC11 WFDC2 HOXA11 PLAC8 SALL1 MECOM SIX2 ROBO2 WNT11 HOXA6 IRX1 IRX2 EMX2 OSR1 FGF2 GFRA1 NPNT POU3F3 PAX2 WNT4 BMP4 ITGA8 GREM1 GDNF CTNNB1 PAX8 LHX1 EYA1 ID4 ITGB1 HOXB4 WT1 WNT9B RET HNF4A Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4G1 DIS3L2 EIF4A2 EIF4A1 EIF4E EIF4B PAIP1 TUT7 PABPC1 PABPN1 TUT4 EIF4A3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 PHYH SLC25A17 PECR SLC27A2 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency OTC DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling PRKAR2B CALM1 PRKACA PDE1C PRKCE PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ITPR1 ADCY5 ITPR2 ITPR3 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 PLCG1 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR FDX1 FDXR FDX2 CYP11A1 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation PTK6 PTPN1 SRMS GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism CHST5 CD44 SPAM1 CHST2 CHST3 PAPSS2 PAPSS1 EXTL2 GPC1 HAS1 HAS3 GPC3 SLC17A5 IDUA GPC2 HEXB HAS2 NCAN GPC5 HEXA GPC4 BGN EXTL3 DCN GPC6 GLB1L3 GLB1L2 BCAN LYVE1 VCAN B3GNT3 FMOD GLB1L AGRN CHPF GLB1 NAGLU HYAL1 CHP1 HYAL3 SLC26A11 HYAL4 CSPG5 IDS CSGALNACT1 CSPG4 GUSB CSGALNACT2 ARSB KERA SLC26A2 CEMIP SLC26A1 HMMR DSEL CTSL B3GALT6 UST OGN HPSE B4GALT2 B4GALT3 B4GALT1 SLC9A1 SGSH HS2ST1 DSE HS3ST3B1 CHPF2 PXYLP1 B4GALT6 B4GALT7 B4GALT4 B4GALT5 PRELP ACAN CHSY1 CHSY3 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 GALNS SLC35B3 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 HS6ST1 ST3GAL4 HS6ST2 HS6ST3 ST3GAL1 NDST2 ST3GAL2 NDST1 ST3GAL3 NDST4 NDST3 GLCE OMD ABCC5 HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 SLC35D2 GNS CHST11 CHST12 CHST15 CHST13 ST3GAL6 CHST14 EXT1 EXT2 B4GAT1 SDC1 STAB2 HYAL2 CHST6 CHST7 B3GNT7 B3GNT4 FAM20B CHST1 B3GNT2 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders HDAC3 NCOR1 TBL1XR1 TBL1X CALM1 PRKACA HDAC1 SIN3A CAMK4 GPS2 NCOR2 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol DCAF13 KRR1 RPS2 FCF1 THUMPD1 PWP2 RPS14 RRP9 IMP3 WDR75 IMP4 NOP2 SNU13 NOP58 RRP7A PDCD11 GAR1 DHX37 PNO1 TBL3 MPHOSPH10 NOL11 NAT10 WDR46 WDR43 RPS9 UTP14A UTP14C RPS7 WDR36 RPS6 TSR3 HEATR1 NOC4L TRMT112 NOL6 RRP36 UTP6 UTP4 UTP3 FBL DIMT1 DKC1 NHP2 UTP25 EMG1 UTP20 NOP14 RCL1 NOP10 DDX49 DDX47 WDR3 BUD23 NOP56 UTP15 UTP11 DDX52 UTP18 BMS1 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane PRKAG1 CALM1 PRKAG2 YWHAE SFN PRKAG3 RAC1 YWHAH STXBP3 LNPEP RAB8A YWHAZ EXOC8 EXOC7 RALA VAMP2 YWHAB RAB4A STX4 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 MYO5A KIFAP3 RAB11A AKT2 AKT1 PRKAB2 PRKAB1 YWHAG MYH9 SNAP23 KIF3B KIF3A C2CD5 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 PRKAA2 ASPSCR1 RAB10 RAB14 RAB13 YWHAQ MYO1C TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression RARA HELLS MYCN TNRC6A TNRC6B KLF16 TGFBR3 MYOG MYOD1 TCF12 MYF6 TCF4 SP1 MYF5 EP300 TCF3 MOV10 SMAD4 AGO3 SMAD3 AGO4 RXRA AGO1 AGO2 TNRC6C GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism GALT GALE AKR1B1 GALM PGM1 GALK1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG MTRR MTR PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport BSG SLC16A7 SLC16A8 EMB SLC16A3 SLC16A1 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL NODAL DAND5 ACVR2A LEFTY1 ACVR1C CRIPTO3 CRIPTO ACVR1B LEFTY2 ACVR2B CFC1 CER1 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes PITPNB LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy PRKAA2 PRKAB1 PRKAG1 PLIN2 PRKAG2 PLIN3 PRKAG3 PRKAB2 HSPA8 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation HGS RAB7A KPNA1 UBA52 ATP6V1H RAB5A KPNB1 VPS33B NOS2 CORO1A UBB UBC RPS27A POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation STAT3 DPPA4 ZIC3 SALL1 SALL4 NANOG EPHA1 POU5F1 SOX2 FOXD3 CRIPTO FGF2 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation CD4 AP2B1 ATP6V1H ARF1 AP2A1 AP2S1 AP2A2 LCK AP2M1 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) H2AX ANAPC15 ANAPC16 ANAPC7 JUN UBE2C UBA52 UBE2E1 UBE2D1 ANAPC10 ANAPC11 IL6 CDC23 UBE2S CXCL8 CDC26 CDC27 H3-3B RELA CDC16 RPS6KA1 VENTX H3C8 ANAPC4 FOS ANAPC5 ANAPC1 ANAPC2 UBB H2AJ CCNA2 CCNA1 UBC RPS27A CEBPB NFKB1 H3C15 MAPK7 CDKN2D CDKN1A CDKN2B CDKN1B CDKN2C CDKN2A FZR1 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 STAT3 H2BC1 CDK6 MAPK3 CDK4 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 EHMT2 EHMT1 IL1A H2BC11 RPS6KA3 RPS6KA2 H4C9 H2AZ2 IGFBP7 H2AC20 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations POMT1 MGAT5B DAG1 POMGNT1 POMT2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle PPFIA3 PPFIA2 SNAP25 SYT1 UNC13B VAMP2 CPLX1 STX1A TSPOAP1 SLC18A2 SYN3 SYN2 SYN1 RAB3A RIMS1 PPFIA1 PPFIA4 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER TFPT MCRS1 INO80 COPS3 COPS6 CETN2 COPS8 UBA52 COPS5 UBB UBC RPS27A GPS1 RBX1 COPS4 RUVBL1 COPS2 NFRKB PARP1 PARP2 ACTR5 ACTB RAD23A CUL4A ACTR8 DDB1 YY1 RAD23B INO80C INO80B ACTL6A CUL4B INO80E INO80D COPS7B DDB2 COPS7A XPC RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs H2AX RHOC YWHAE PPP1R12A SFN PPP1R12B CDC25C PPP1R14A RAC1 H3-3B MYH14 MYH10 H3C8 YWHAH H2AJ KLK3 KLK2 KDM4C YWHAZ H3C15 PAK1 MYL12B PPP1CB MYH11 H2BC9 YWHAB H2BC8 H2BC5 H2BC3 H2BC1 MYL6 H2AB1 AR H2AC8 H2AC6 H2AC7 H2AC19 H2AC14 H2BC12L RHOA H2BC26 H2BC21 YWHAG MYH9 PDPK1 RHOB H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 PKN3 NCOA2 KDM1A H2BC11 H4C9 YWHAQ PKN2 H2AZ2 PKN1 MYL9 H2AC20 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA DBT BCKDHB DLD REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response BAG5 POM121C HSPH1 NUP42 ATM NUP62 DNAJB6 NUP43 BAG3 TPR ATR HSF1 BAG1 NUP88 YWHAE RAE1 HSPA4 ST13 NUP214 RANBP2 HSPA7 NDC1 HSPA6 NUP210 HSPA12A NUP155 HSPA12B NUP153 HSPA1A NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA5 HSPA1B MAPK1 MAPK3 BAG2 NUP107 HSPA8 MAPKAPK2 NUP160 NUP85 GSK3B SEC13 NUP133 SIRT1 HSPA1L HIKESHI CCAR2 RPA1 DNAJC2 RPA2 DNAJC7 RPS19BP1 HSPA2 NUP205 HSPA4L POM121 HSPA14 RPA3 NUP188 HSPA13 DNAJB1 AAAS BAG4 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling IL32 CD4 SNAP25 SDC1 CSF1R CSF3 IL10RB VAMP2 IL34 STX1A IL16 CSF1 IFNLR1 TYK2 IFNL1 TXLNA CASP3 JAK1 PTPRZ1 PRTN3 STX4 STX3 CSF3R STXBP2 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events POM121C NUP42 NUP62 NUP43 H2BC18 TPR NUP88 CHMP2B RAE1 CHMP2A NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 H3C8 NUP37 HNRNPK H3C15 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 NUP107 H2AC8 H2AC6 H2AC7 CEBPD H2AC17 H2AC12 H2AC1 NUP160 H2AC19 H2AC25 H2AC14 H2AC21 NUP85 H2BC26 CHMP1A H2BC21 H2BC17 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 TSG101 VPS4A MVB12B H2BC11 MVB12A VPS36 VPS37C CHMP4C VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A H4C9 CHMP6 SNF8 CHMP7 UBAP1 VPS25 VPS28 NUP205 POM121 H2AC20 NUP188 AAAS HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism HAL AOC1 CARNMT1 UROC1 AMDHD1 HDC CARNS1 HNMT FTCD EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids CYP8B1 CYP4F2 CYP4F3 CYP4A11 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 PTGIS TBXAS1 CYP4F12 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER LIG1 UBA52 POLK POLE RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 RPS27A PCNA POLD3 POLD4 POLD1 POLD2 XRCC1 LIG3 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis STARD3 FDX1 STARD4 FDXR STAR FDX2 STARD6 STARD3NL TSPO CYP11A1 AKR1B1 TSPOAP1 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport PSMA5 PSMA6 EIF2S3 PSMA3 PSMA4 PSMA1 EIF2S2 PSMA2 EIF2S1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCA6 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ABCD1 RPS27A ABCG1 DERL3 ADRM1 DERL1 DERL2 SEM1 ABCB7 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 ABCD2 PSMC2 ABCD3 ABCC10 ABCC11 ABCA10 PEX3 ABCG4 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ABCA5 ABCA4 ABCC1 ABCA9 ABCA7 ABCA8 ABCB10 ABCA12 ABCG8 ABCG5 ABCB6 VCP ABCB4 ABCC4 ABCC9 SEL1L ABCC5 ABCA3 ABCC6 RNF185 ABCB1 KCNJ11 ABCC2 APOA1 RNF5 ABCC3 ERLEC1 PSMD8 CFTR PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PEX19 PSMD3 PSMD1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors CALM1 DLG1 DLG3 DLG4 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 NCALD PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 RB1 CCNE1 CDK2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions ITGA2B COL9A2 CD44 FN1 VTN AGRN ITGB5 ITGA10 CDH1 KDR ITGA9 ITGAM ITGB2 TNC ICAM4 ICAM5 ITGAE COMP IBSP BSG ITGAX ITGB7 ITGAD CD47 JAM2 JAM3 ITGAV ITGA11 FBN1 HSPG2 SPP1 ITGAL F11R ICAM1 PECAM1 COL18A1 ITGB8 THBS1 COL16A1 ITGB6 COL13A1 ICAM2 ICAM3 ITGA8 ITGA4 ITGB1 ITGB3 ITGA5 COL23A1 COL4A2 FGB ITGA3 COL4A1 FGA ITGA2 ITGA1 FGG COL4A4 ITGA7 ITGA6 COL4A3 VCAM1 COL9A1 LUM COL9A3 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis CCNC PPARGC1B MED9 CDK19 CEBPB MED16 MED15 MED17 CCND3 MED12 MED14 MED13 MED10 PCK1 SREBF2 CDK4 NR2F2 MED27 MED26 MED23 MED25 MED24 MED20 CDK8 CEBPD ADIPOQ HDAC3 SMARCD3 CHD9 TGFB1 MBD3 HELZ2 TGS1 EP300 GATAD2B TBL1X GATAD2A PPARGC1A NCOA1 MED1 NCOA2 CREBBP SLC2A4 HDAC2 NCOA6 NCOR1 TBL1XR1 CARM1 CHD4 RBBP4 CHD3 CEBPA RBBP7 KLF5 KLF4 MTA2 TNF RELA MED8 ANGPTL4 MED4 MED6 MED7 NFKB1 LPL UCP1 HNRNPU MTA1 PRDM16 HDAC1 ZNF423 MED30 MTA3 ELOVL3 CIDEA EBF2 MED31 BMP7 FABP4 COX7A1 SMAD1 SMAD4 PLIN1 RXRA PPARG PPARA CD36 EBF1 EGR2 MED19 ADIRF MED18 THRAP3 MED11 ZNF638 MED29 FAM120B MED28 NCOR2 ZNF467 MED22 LEP MED21 WNT1 WNT10B MED13L NCOA3 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands TMEM219 TNFRSF10B PPP1R13B IGFBP3 TNFRSF10A TNFRSF10C TP53BP2 TP73 FAS TP63 TNFRSF10D TP53 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation DHDDS DPM1 DPM2 DPM3 CHST3 GNE PAPSS2 GPC1 GPC3 GPC2 NEU1 HEXB NCAN GPC5 HEXA GPC4 BGN DCN GPC6 CTSA NUS1 ALG11 BCAN VCAN FMOD AGRN GLB1 SRD5A3 GFPT1 DOLK CSPG5 NOTCH2 CSPG4 KERA NOTCH3 NOTCH4 SLC26A2 POMT2 SEMA5A GALNT12 SPON2 SEMA5B SPON1 B3GALT6 THSD7B POMT1 ADAMTS4 ADAMTSL1 LFNG OGN ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 GALK1 ADAMTSL5 ADAMTSL4 ADAMTS1 B4GALT1 ADAMTSL3 ADAMTSL2 MUC12 MUC13 THSD7A MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 PGM1 POMGNT1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 B4GALT7 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 GALT MUC7 MUC4 MUC6 PRELP GALNT3 MUC16 ACAN MUC17 CHSY1 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 B3GAT3 LUM GALE GALM ALG14 ALG13 NOTCH1 MGAT2 PMM2 MPI ST3GAL3 MOGS OMD DAG1 HSPG2 MAN1B1 DPAGT1 ALG8 SDC4 ALG9 SDC2 ALG6 SDC3 ALG2 ALG3 ALG12 ALG1 MPDU1 THBS1 RFT1 CHST14 EXT1 EXT2 B4GAT1 SDC1 CHST6 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias ABCC8 KCNJ11 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm MIXL1 CTNNB1 GATA4 FOXA2 SMAD2 TCF7L2 SMAD4 EOMES SMAD3 GATA6 CXCR4 TBXT SOX17 CDH1 GSC SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections MAGT1 JAK1 VAV1 BRD4 IFNB1 VHL STAT1 TUSC3 BCL2L1 EEF1A1 ZBP1 TBK1 TMEM258 IRF3 VCP GEMIN2 OST4 SNRPD2 SNRPD1 SNRPD3 OSTC STT3A SNRPG STT3B GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 GSK3B CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 YWHAG PDPK1 DDOST DAD1 RBBP4 RBBP7 PTPN11 PTPN6 PDCD1 AP2A1 AP2A2 AP2M1 BECN1 UVRAG MAP1LC3B ISCU AP2S1 GJA1 AP2B1 ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 BTK MGAT1 MGAT2 GOLGA7 PLCG2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 LARP1 EDEM2 MOGS SYK ZDHHC11 MGAT4C ZDHHC9 MGAT4A MGAT4B HSPG2 MAN1B1 ST6GALNAC3 ST6GALNAC4 SDC4 SDC2 VPS33A SDC3 VPS33B ZCRB1 PYCARD G3BP1 G3BP2 CYSLTR1 HNRNPA1 SDC1 CNBP NLRP3 PCBP2 BST2 SFTPD NLRP12 NUP205 ARID4A POM121 IL17F ARID4B FNTA IL17A NUP188 FNTB AAAS IL1R1 POM121C SAP30 BRMS1 NUP42 IFNAR1 PPIH NUP62 PHF21A TPR PPIG CD79B PPIB NUP88 CD79A RAE1 SUDS3 RCOR1 NUP214 IGHM SFN NDC1 BLNK NUP210 HMG20B JAK3 NUP155 IFNGR1 GPC1 IFNGR2 NUP153 NUP93 SIGMAR1 TYK2 GPC3 NUP50 IGHD NUP35 GPC2 NUP54 SAP30L S1PR1 SAP18 GPC5 CRBN GPC4 VPS39 STAT2 VPS18 GPC6 ATG14 VPS11 VPS16 AGRN RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC RCAN3 RPS11 KPNA2 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA VPS41 NPIPB3 VPS45 KPNB1 RPS4Y2 RPS4Y1 HLA-H HLA-C HLA-F HLA-G MBD3 HLA-E NMI ISG15 RPS26 TOMM70 RPS25 IL17RC RPS28 IL17RA RPS29 TLR1 GATAD2B GATAD2A RPS20 TLR2 RPS21 RPS24 RPS23 RPS4X HSP90AA1 RPS3A IKBKB CANX RPS27L IKBKG RPS15A MAP3K7 RPS3 CHUK RPS2 UBA52 FAU RIPK2 HLA-B RELA RUNX1 TRAF3 UBB IKBKE UBC RPS27A NFKB1 NFKBIA PSMC6 MTA1 NOD1 MTA3 NOD2 IRAK2 UBE2I NR3C1 SUMO1 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 ITGA4 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ANO10 HLA-A B2M SH3KBP1 TUBB TUFM YWHAB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 CTSL IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 UBE2V1 IGKV2D-30 IGHV4-59 IGHV1-69 NPM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 CSNK1A1 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N EP300 TAB3 TAB2 TAB1 ITGB1 IRAK1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV CREBBP IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 CHD4 IGKV3D-20 CHD3 TRAF6 NFE2L2 YWHAQ IGLV3-19 IGKV2-30 IGHV2-70 PPIA IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 FKBP1A IGKV1-39 MTA2 IGKV1-33 YWHAE IGHV3-53 REST IGLC7 IGKV5-2 IGKV1-5 IGLC6 YWHAH RBX1 YWHAZ HDAC1 CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI SRPK2 SRPK1 IMPDH1 IMPDH2 NRP1 HSP90AB1 ROCK1 ROCK2 KDM1A FKBP4 NCK1 DDX5 PTGES3 FURIN CUL3 TMPRSS2 ACE2 RB1 HAVCR1 SEC23A NUP107 SAR1B SEC24B SEC24A COMT SP1 SEC24D NUP160 SEC24C NUP85 PIK3R4 RPS27 SEC13 CASP1 TLR9 NUP133 PIK3C3 RIPK3 HDAC2 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 IL6R RIPK1 KEAP1 NUP43 ITCH CHMP2B CHMP2A RANBP2 NUP37 PRMT1 TRIM4 TJP1 SMAD4 SMAD3 ATP1B3 ATP1B2 ATP1B1 ATP1A4 ATP1A3 AKT2 TLR8 ATP1A2 TLR7 AKT3 ATP1A1 AKT1 MASP1 MBL2 RPN2 FXYD4 FXYD3 RPN1 FXYD2 FXYD1 FXYD7 FXYD6 JAK2 IRF7 STING1 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis HSD3B2 CYP11B2 CYP21A2 CGA HSD3B1 LHB LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake NR1H2 RXRB RXRA NR1H3 MYLIP ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHRNA9 CHRND CHRNG CHRNE SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions PPIH RPS2 PPIG FKBP1A PPIB ITCH YWHAE UBA52 SFN FAU RELA RUNX1 YWHAH TRAF3 UBB IKBKE UBC RPS27A NFKB1 NFKBIA YWHAZ PSMC6 YWHAB RPS15 RPS14 RPS17 IRAK2 RPS16 UBE2I RPS19 RPS18 TKFC CAV1 SMAD4 SMAD3 BCL2L1 RCAN3 RPS11 KPNA2 EEF1A1 IFIH1 RPS10 RPS13 TBK1 TRIM25 RPS12 RPS9 IRF3 RPS7 RPS8 SIKE1 RPS5 MAVS RPS6 RIGI RPSA NPM1 NPIPB3 SP1 KPNB1 RPS4Y2 RPS4Y1 PYCARD TLR7 PALS1 NMI TOMM70 RPS26 RPS25 RPS28 RPS27 YWHAG HNRNPA1 RPS29 EP300 PDPK1 RPS20 CASP1 RPS21 NLRP3 RPS24 RPS23 RIPK3 PCBP2 RPS4X BST2 RPS3A SFTPD TRAF6 YWHAQ RPS27L PPIA RPS15A STING1 RPS3 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 GNAI3 GNGT1 GNG10 GNGT2 GNG12 GNG3 GNG11 GNAI1 GNG13 GNG2 GNAI2 P2RY12 GNG5 GNB2 GNG4 GNG7 GNB1 GNAT3 GNG8 GNB4 GNB3 GNB5 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 IMP4 SNU13 RRP7A PDCD11 ERI1 GAR1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 NOL9 NOC4L NOL6 EXOSC10 PES1 CSNK1E RRP36 UTP6 UTP4 RIOK3 UTP3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 FBL MTREX RPP38 DIMT1 FTSJ3 EBNA1BP2 DKC1 NHP2 RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 NOP14 RPP40 RCL1 NOP10 RBM28 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 SENP3 UTP18 C1D DDX21 BMS1 RPP14 DCAF13 KRR1 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 XRN2 NCL MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN MRM1 HSD17B10 MRM2 MRM3 NOP56 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 TRMT112 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L ELAC2 RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A NOP2 NOP58 CSNK1D GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV GYG2 GBE1 GYS2 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells UPK1A EPCAM REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation TNRC6A CD274 TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants KIT PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) ITGA2B MPL SOS1 CRK FN1 SYK PTK2 THPO RASGRP2 GP9 GP1BB GP5 ADRA2C ADRA2B ADRA2A SRC AKT1 BCAR1 GP1BA PDPK1 ITGB3 RAP1B SHC1 FGB FGA RAP1A VWF FGG APBB1IP F2 RAPGEF3 CSK PTPN1 TLN1 RAPGEF4 RASGRP1 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R IGF1R HRAS SOS1 IGF2 IGF1 NRAS EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling EPHA10 EFNA5 EFNA4 EFNB2 AP2A1 EFNB1 EPHB2 EFNB3 AP2A2 RASA1 EPHA1 EPHA2 EFNA1 EFNA3 ARHGEF7 EFNA2 NGEF RAC1 AP2M1 MMP9 KALRN LIMK2 LIMK1 MYH14 MYH10 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B MYL12A PAK1 MYL12B AP2S1 PAK3 PAK2 DNM1 MYH11 AP2B1 HRAS GRIN2B ACTB TIAM1 CLTB MYL6 ARPC1B ADAM10 ARPC1A CFL1 VAV3 WASL PTK2 VAV2 SDC2 GRIN1 RHOA CLTCL1 ROCK1 ROCK2 MYH9 ACTG1 ARPC4 CLTC ARPC5 ITSN1 ARHGEF28 ARPC2 CLTA NCK2 GIT1 ARPC3 ACTR3 ACTR2 LYN CDC42 YES1 EPHB6 EPHB1 EPHB4 FYN EPHB3 EPHA5 EPHA4 EPHA7 SDCBP EPHA6 MYL9 EPHA8 MMP2 EPHA3 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2AX MTA2 SMARCB1 DNMT3L SPOCD1 C19orf84 DNMT3A H3-3B SMARCC1 H3C8 SMARCC2 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 SMARCA2 ACTB H2BC1 SMARCA4 ACTL6A H2AB1 H2AC8 H2AC6 BCL7A H2AC7 BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SS18L1 ARID1A ARID1B H2AC19 SMARCD3 H2AC14 H2BC12L MBD3 H2BC26 H2BC21 PIWIL4 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SMARCD1 HDAC2 SMARCD2 H2BC11 H4C9 CHD4 RBBP4 CHD3 RBBP7 SMARCE1 H2AZ2 H2AC20 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH H2AX TMED2 CCNC H3-3B H3C8 H2AJ H3C15 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 MIB2 H2BC1 SNW1 EGF H2AB1 TLE1 H2AC8 H2AC6 H2AC7 JAG2 JAG1 ADAM10 DTX4 DLL1 MIB1 SEL1L DLL4 NEURL1B ADAM17 NEURL1 HDAC3 MAMLD1 H2BC26 H2BC21 EP300 TBL1X H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP H2BC11 NCOR1 TBL1XR1 H2AZ2 TNRC6C TNRC6A TNRC6B JUN MAML2 MAML1 FCER2 PSENEN PSEN2 RAB6A PSEN1 APH1A NCSTN APH1B HES5 HEYL NOTCH1 RBX1 YWHAZ HDAC1 FABP7 ST3GAL4 ST3GAL3 TP53 NCOR2 KAT2B KAT2A ST3GAL6 RBPJ PLXND1 WWC1 DLGAP5 PTCRA PBX1 TACC3 WWP2 FURIN RFNG POGLUT1 POFUT1 MFNG FLT4 MDK ACTA2 CNTN1 NOTCH2 NOTCH3 NOTCH4 HEY1 CCND1 E2F1 NUMB E2F3 HEY2 TFDP1 TFDP2 SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB CDK8 LFNG NBEA EGFR B4GALT1 HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 ELANE GZMB PSMA5 PSMA6 ITCH PSMA3 PSMA4 HDAC10 PSMA1 HDAC11 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRKCI CUL1 PSMA7 PSMB6 RUNX1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DNER TLE4 TLE2 HDAC4 DTX1 DTX2 DLK1 SMAD3 ATP2A3 ATP2A2 ATP2A1 YBX1 H2AC19 H2AC14 H2BC12L MYC AKT1 HES1 ARRB1 ARRB2 HIF1A H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA LINGO1 MAG MCF2 OMG RTN4 RHOA NGF NGFR DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH GGT1 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria KHK BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA ACADS HADHB HADHA ECHS1 HADH DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) FOS NAB1 NAB2 SH3GL3 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 MAPK7 LYL1 F3 SH3GL2 VGF ELK1 ASCL1 RALA CDK5R2 SHC2 RALB SHC3 DNM1 SHC1 DNM3 YWHAB NTRK2 CRKL ADORA2A NRAS RAP1A MAPK1 STAT3 HRAS RALGDS MAPK3 NTRK1 MAP2K1 PLCG1 FOSB MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 DNM2 RIT2 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 RAPGEF1 SOS1 CRK ATF2 IRS1 IRS2 RHOA PIK3CB RPS6KA5 EP300 ID4 EGR1 MEF2D CLTC PIK3CA PPP2R5D MEF2C CLTA CHD4 PPP2CA PPP2CB AP2A1 AP2A2 REST AP2M1 JUNB CDK5 RPS6KA1 ATF1 CDK5R1 MEF2A DUSP4 DUSP3 VRK3 DUSP6 DUSP7 SGK1 AP2S1 AP2B1 ID1 ADCYAP1 ADCYAP1R1 EGR2 TCF12 PIK3R2 SRF PIK3R1 RPS6KA3 RPS6KA2 JUND NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation UBE2M AMER1 KBTBD13 UBE2D1 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 VHL UBE2D2 NEDD8 FBXL19 CAND1 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 VCP COPS5 WDR5 RBBP5 NFE2L2 RBBP7 DCAF13 ELOB COP1 ELOC RBX1 DCAF7 FBXO4 FBXO6 FBXW4 CISH FBXW5 FBXW10 FBXW7 FBXW9 SOCS2 FBXW2 FBXL3 FBXL5 GPS1 SENP8 UCHL3 CUL2 COPS4 COPS2 UFD1 CUL3 KBTBD7 NPLOC4 CDKN1A DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 SQSTM1 DCUN1D5 SKP2 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 COMMD9 PUM2 HIF3A DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 DDB2 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CUL9 UBD NAE1 SOCS6 WDTC1 SOCS5 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B NEURL2 ERCC8 UBE2D3 BIRC5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 LRR1 CCNF BTRC COPS7B KEAP1 COPS7A SKP1 FBXW11 PSMA5 COPS3 PSMA6 COPS6 PSMA3 PSMA4 PSMA1 PSMA2 COPS8 UBA52 FBXO7 PSMD12 FBXO9 PSMD11 WSB1 PSMD14 FBXO2 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 FBXL8 FBXL4 PSMC5 PSMC6 FBXL7 PSMC3 PSMC4 PSMC1 PSMC2 SOCS3 LRRC41 GAN KCTD6 KLHL2 KLHL3 CUL4A DDB1 KLHL9 SPSB2 DTL SPSB1 KBTBD6 CUL4B KLHL5 KBTBD8 SPSB4 FBXO27 FBXO32 BRCA1 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 CUL7 CUL5 KLHL11 EPAS1 UBXN7 KLHL13 FBXO44 FBXO41 FBXO40 HIF1A MUL1 DPP3 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 PALB2 FBXO31 KLHL20 UBA3 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair PARP1 PARP2 POLB APEX1 PARG ADPRS LIG1 FEN1 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation SCN11A SCN9A CALM1 SCN1B SCN1A CACNA2D2 SCN10A SCN8A CAMK2B CAMK2D CAMK2A SCN3B SCN3A CACNA1C CACNG6 FGF14 RANGRF FGF13 FGF12 CACNG7 CAMK2G FGF11 CACNB1 SCN2A CACNB2 SCN2B CACNG8 SCN5A CACNG4 SCN4A SCN4B SCN7A SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins POM121C SUMO2 NUP42 PHC2 NUP62 NUP43 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 RANBP2 PHC3 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 BMI1 NUP160 RING1 NUP85 NUP37 RNF2 HNRNPK SEC13 NUP133 PCGF2 UBE2I NOP58 HNRNPC NUP205 POM121 NUP107 NUP188 SUMO1 AAAS CBX8 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling CSH1 STAT5A PRLR STAT5B RBX1 GHR GH2 GH1 JAK2 CUL1 PTPN11 BTRC PRL SKP1 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes EP300 TKT PGD NFE2L2 CREBBP G6PD TALDO1 MAFG REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells NKX6-1 PDX1 HNF1B PTF1A FGF10 ONECUT3 ONECUT1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA MCM6 MCM2 ANAPC15 ANAPC16 ANAPC7 UBE2C LIG1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ORC5 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 FZR1 SKP2 CCNE2 CCNE1 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 FEN1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 POLE RFC5 RFC3 RFC4 RFC1 RFC2 DNA2 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 GINS1 RPA2 GINS2 CDC45 POLE4 MCM7 GINS3 GINS4 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 MUC12 ST6GALNAC4 MUC13 MUC15 MUCL1 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 ST6GALNAC2 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 ST3GAL4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination NFIA CRCP NFIB NFIC POLR2K POLR2L POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H POLR3K POLR2E POLR2F SSB NFIX POLR2H APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation DFFB DFFA HMGB2 H1-1 KPNA1 H1-0 H1-3 H1-2 H1-5 H1-4 CASP3 KPNB1 HMGB1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) RAD1 ATM RAD9B ATR RAD9A ERCC4 MRE11 ERCC1 BRCA1 RAD52 LIG1 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 DNA2 RHNO1 BLM WRN BRIP1 ABL1 RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration RND1 RRAS MET PLXNB1 RHOA RAC1 SEMA4D ARHGAP35 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling PPP2CA PPP2CB PPP2R1A UBA52 KLB UBB FGF1 FGF2 UBC FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF16 MKNK1 FGF19 FGF18 SPRY2 FGFR4 MAPK1 MAPK3 FRS2 BRAF PTPN11 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1C RB1 CDKN1A CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription CDC6 RRM2 POLA1 RBL2 RBL1 CDK1 ORC1 CCNA1 CDT1 FBXO5 LIN54 PCNA LIN52 LIN37 HDAC1 LIN9 E2F1 E2F4 DHFR TK1 TYMS E2F5 E2F6 TFDP1 RBBP4 TFDP2 CCNE1 CDC45 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation HPN SPINT2 MET HGF HGFAC SPINT1 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate ZNF521 NANOG PAX6 POU5F1 SOX2 ZEB2 ZIC2 SOX1 GBX2 OTX2 POU3F1 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair ACD H2AX MPG LIG1 TERF1 TERF2 H2AJ POT1 TERF2IP FEN1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 POLB H2BC1 APEX1 XRCC1 LIG3 H2AB1 H2AC8 H2AC6 H2AC7 POLE H2AC19 H2AC14 RFC5 PARG H2BC12L RFC3 ADPRS RFC4 RFC1 RFC2 H2BC26 H2BC21 OGG1 NTHL1 H2BC17 TDG MBD4 H2BC12 SMUG1 H2BC13 NEIL3 PCNA H2BC14 NEIL2 H2BC15 NEIL1 POLD3 PNKP POLD4 H2BC11 POLD1 POLD2 PARP1 PARP2 H4C9 TINF2 RPA1 RPA2 POLE4 H2AZ2 RPA3 H2AC20 POLE2 POLE3 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 PRELP ACAN ST3GAL3 KERA OGN OMD FMOD LUM RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates ATM MUS81 MRE11 BRCA1 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM NBN GEN1 RMI2 SLX1B RMI1 TOP3A SPIDR SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 SLX4 FIGNL1 RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids ADH7 CYP2A7 CYP4F2 CYP4A11 CYP2B6 CYP2A13 CYP2D6 CYP2F1 CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 CYP2J2 CYP4F12 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNQ2 KCNQ3 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency CPS1 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes EP300 ABCC3 ABCC1 MAFK NFE2L2 ABCG2 CREBBP ABCF2 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly HSP90AA1 IPO5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins ITGA2B ITGB3 SOS1 FN1 PTK2 RAP1B FGB FGA RAP1A VWF FGG APBB1IP TLN1 SRC INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling JAK1 STAT5A STAT3 STAT5B IL2RG IL9 JAK3 IL9R STAT1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 H2BC17 H2BC12 H2BC13 NEIL3 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 NEK7 CDK1 CCNB2 PLK1 NEK9 CCNB1 NEK6 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex CDC6 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease SOS1 FGFR1 FGF1 FGF2 CEP43 FGF4 FGF6 FGF9 FGF20 STAT5A FGF23 STAT5B GAB2 ZMYM2 PIK3R1 PIK3CA NRAS STAT1 GAB1 LRRFIP1 STAT3 HRAS BCR CUX1 FGFR1OP2 PLCG1 MYO18A CPSF6 ERLIN2 FRS2 TRIM24 BAG4 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME ALB SLCO1A2 SLC22A8 ABCG2 SLC22A1 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation ACSM5 ACSM4 GLYAT ACSM1 GLYATL3 ACSM2B GLYATL2 GLYATL1 ACSM2A SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions SDK1 SDK2 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism RMND5B LDHB LDHA MAEA PDPR RMND5A MPC1 MPC2 PDK4 PDK3 PC UBA52 MPC1L NEK1 ME3 DLAT ME2 PDK2 PDK1 PDHX PDHA2 FAHD1 PDHA1 SIRT4 ARMC8 PDP1 DLD UBB MKLN1 GID4 PDP2 UBC GSTZ1 GID8 LDHAL6A RPS27A LDHAL6B VDAC1 ME1 RANBP9 WDR26 GLO1 GPT PDHB LDHC BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding KLB FGF19 FGFR4 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation TBK1 TICAM1 TANK TRAF3 UBB UBA52 IKBKE TLR3 OPTN UBC RPS27A STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses TBK1 IRF3 NLRP4 MRE11 DTX4 TRIM21 CGAS DDX41 PRKDC NLRC3 IFI16 STAT6 XRCC6 XRCC5 TREX1 STING1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium EXOC1 EXOC8 ARF4 EXOC7 ASAP1 PKD2 PKD1 GBF1 RAB11FIP3 RAB11A RHO CNGA2 CNGA4 CNGB1 RAB3IP EXOC4 EXOC3 EXOC6 EXOC5 RAB8A EXOC2 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer RAC1 PDGFRA VAV1 SRC PDGFRB TRAT1 PDGFB NTRK3 PIK3AP1 MET TGFA FLT3LG KIT EREG RAC2 BTC EPGN HBEGF NTRK2 BDNF GAB1 NTF4 NTF3 CD86 EGF ESR1 CD80 FRS2 FLT3 AREG ESR2 CD19 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF PIK3CD IRS2 FGF1 PIK3CB FGF2 ERBB2 PIK3CG FGF3 NRG1 FGF4 STRN FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 PIK3R3 PIK3R2 PIK3CA PIK3R1 FGFR4 FGF10 LCK PIK3R6 PIK3R5 FYN RHOG PTPN11 CD28 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PTPN6 SOS1 SOCS6 PRKCA RAC1 MMP9 CHEK1 VAV1 CBL STAT5A PTPRU STAT5B SH2B3 SH2B2 GAB2 CMA1 FER TEC KIT PIK3R3 FES PIK3R2 GRAP PIK3R1 PIK3CA SOCS1 JAK2 LCK GRB7 GRB10 NRAS STAT1 LYN STAT3 HRAS YES1 FYN GRAP2 PTPN11 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints RAD1 ATM RAD9B ATR H2AX RAD9A ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 MDM2 UBE2S MDM4 CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CCNA2 CCNA1 CDKN2A H2BC9 H3-4 H2BC8 YWHAB H2BC5 H2BC3 H2BC1 MAPK14 MAPK11 CDC6 CSNK1E CSNK1A1 NEK11 GSK3B XPO1 H2BC26 H2BC21 UBE2N YWHAG H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 YWHAQ YWHAE PHF20 CHEK2 GTSE1 CDC25C ZNF385A COP1 PCBP4 CDC25A YWHAH RBX1 YWHAZ PLK3 WEE1 CDC7 TP53 MDC1 CDC45 MCM7 MCM3 MCM4 MCM5 MCM6 MCM2 SFN ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 CDKN1A CDKN1B CCNE2 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 PSMD8 KIF2C KIF2B PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA BTRC AURKB NSL1 SKP1 CENPC PPP2CA PPP2CB FBXW11 NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CLASP1 HERC2 PSMA4 DYNC1I1 PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CUL1 CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 MCM10 PSMC5 PSMC6 DBF4 PSMC3 PSMC4 PSMC1 PSMC2 PKMYT1 PIAS4 BRCC3 CLSPN TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 NSD2 MRE11 BRCA1 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A UBE2V2 HUS1 DNA2 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 RAD50 RPA3 RAD17 INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade SDC1 F3 PROS1 F5 F8 SERPINC1 GPC1 F10 HSPG2 GPC3 VWF GPC2 SDC4 SDC2 GPC5 SDC3 F7 GPC4 F2 F9 GPC6 AGRN MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 CD274 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 COPS5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 NEK2 BTRC SKP1 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation GJA1 DNM2 MYO6 CLTB DAB2 CLTCL1 CLTC DNM1 CLTA AP2M1 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation UBE2L6 FURIN H2AX INS APP UBA52 SNCA H3-3B APOA4 B2M H3C8 UBB PSENEN UBC APH1A SIAH2 NCSTN RPS27A SIAH1 APH1B PRL H3C15 GGA2 GGA1 GGA3 CALB1 H2BC9 NAT8B H2BC8 BACE1 APOE H2BC5 MFGE8 APCS H2BC3 TSPAN33 CST3 TTR H2BC1 TSPAN5 H2AZ1 ODAM SAA1 LYZ SNCAIP SORL1 TSPAN15 H2AB1 TSPAN14 NAT8 SEMG1 GSN TGFBI H2AC8 ITM2B H2AC6 H2AC7 IAPP CALCA ADAM10 HSPG2 H2AC19 H2AC14 H2BC12L NPPA H2BC26 H2BC21 USP9X H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 APOA1 H2BC11 FGA H4C9 LTF PRKN H2AC20 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling RANBP10 HRAS MET RANBP9 SOS1 HGF MUC20 NRAS TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest PRMT1 AURKA EP300 PCNA BAX SFN TP53 CDC25C ZNF385A CCNB1 E2F4 RBL2 RBL1 TFDP1 CARM1 CDK1 TFDP2 GADD45A HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) PARP1 PARP2 RBBP8 POLQ XRCC1 LIG3 MRE11 RAD52 BRCA2 RAD50 FEN1 NBN MMR%REACTOME%R-HSA-5358508.3 MMR MSH6 MSH2 MSH3 PMS2 MLH1 PCNA LIG1 POLD3 POLD4 EXO1 POLD1 POLD2 RPA1 RPA2 RPA3 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors STAB1 SPARC APOB STAB2 DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins DEFB108C CD4 DEFB130A ART1 DEFB130B DEFA1B DEFB4B PRSS3 PRSS2 DEFA6 DEFA4 DEFA5 DEFA3 CCR6 CCR2 DEFB103B TLR1 DEFB105B DEFB129 DEFB128 DEFB131A TLR2 DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation NANOG POU5F1 SOX2 OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins RHO OPN1LW RRH OPN4 OPN3 RGR OPN1SW OPN5 OPN1MW DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism GATA4 INS PAX6 CTNNB1 UCN EXOC8 ACE2 CMA1 EXOC7 VAMP2 FFAR4 STX1A FFAR1 POMC CTSZ P4HB EXOC4 EXOC3 GRP GNAT3 EXOC6 EXOC5 GIP CPB2 EXOC2 EXOC1 CGA AGT TSHB MYO5A INHBA GH1 LHB CTSG SEC11A CGB8 SEC11C PCSK2 RAB27A PCSK1 MYRIP INHA ERO1B KIF5C ISL1 ANPEP KIF5B ACHE KIF5A LEP CPA3 SLC30A8 MME SLC30A5 ATP6AP2 CES1 ENPEP CPB1 GPR119 PLA2G7 IGF1 CRHR2 BCHE DPP4 CLTRN ACE CDX2 FSHB INHBB MBOAT4 INHBC INHBE GZMH CPE SPCS3 REN SPCS2 SPCS1 CTSD GCG GNG13 GNB1 TCF7L2 GNB3 KLF4 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA POM121C NUP42 NUP62 RCC1 NUP43 TPR NUP88 RANBP1 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 XPO1 NUP37 SEC13 NUP133 RANGAP1 NUP205 POM121 NUP107 NUP188 AAAS SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin MBOAT4 INS UCN GH1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 ACHE LEP GCG IGF1 PLA2G7 BCHE CRHR2 KLF4 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib SLC37A4 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD GCLM GCLC TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades PTPN4 UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 DNM1 MAPK10 DNM3 UBE2D2 MAPK1 MAPK3 MAP2K1 CTSV MAPK14 CTSL CTSK MAP3K8 MAPK11 DNM2 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 PIK3R4 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 APOB TAB1 TLR6 IRAK1 TLR2 TLR9 PIK3C3 RIPK3 PPP2R5D MEF2C TRAF2 PELI1 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 GSDMD CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 GSDME CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 ECSIT IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA EEA1 DUSP6 TASL DUSP7 RBSN TLR10 IRF5 TLR5 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 SLC15A4 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 ITGAM ITGB2 SIGIRR BTK PLCG2 S100A1 CD36 IRAK3 TIRAP TP53 UNC93B1 TLR8 TLR7 TLR3 CTSS LGMN CTSB HSP90B1 TIFA ALPK1 CD180 LY86 LBP BPI SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis CD3G CD3D TFRC SH3GL3 SH3KBP1 STAM CBL HGS EPS15 TGFA STAM2 SYT2 SH3GL2 SH3GL1 SYT1 EREG BTC VAMP2 EPGN HBEGF NEDD8 CLTB EGF AREG TF M6PR VAMP8 VAMP7 EGFR COPS5 SCARB2 ITSN2 SLC18A3 AGFG1 GRK3 CLTCL1 KIAA0319 TOR1A TOR1B APOB SYT9 SYT8 SNAP91 DAB2 AAK1 IL7R PICALM CLTC ITSN1 STON1 CLTA STON2 SLC2A8 SGIP1 EPS15L1 EPN1 EPN2 CFTR LRP2 FCHO1 FCHO2 REPS2 UBQLN1 UBQLN2 COPS7B COPS7A NECAP2 CD4 NECAP1 SYT11 COPS3 COPS6 AP2A1 AP2A2 VAMP3 COPS8 UBA52 VAMP4 LDLRAP1 AP2M1 AGTR1 TGOLN2 UBB UBC IGF2R RPS27A AP2S1 AVPR2 LDLR AVP CHRM2 AP2B1 TACR1 ADRB2 WNT5A GRK2 GPS1 DVL2 FZD4 ARRB1 ARRB2 COPS4 COPS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells HRAS RASGRP1 RASGRP3 NRAS PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling HLA-DRB3 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 ASH2L CD3G CUL3 MAGT1 CD3E CD3D PRKAG3 TEAD1 TEAD2 JAK1 TEAD3 H3-3B HLA-DPA1 TEAD4 H3C8 FOS PDCD1LG2 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 YAP1 DERL3 DERL1 DERL2 TRBV12-3 CTNNB1 H3C15 TRBV7-9 OS9 SPOP BRD4 SUZ12 CCND1 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 TRAV8-4 HLA-DPB1 FOSB CDK4 TUSC3 TRAC H2AB1 NEK2 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 GSK3B DPY30 H2BC26 H2BC21 WDR5 YWHAG EP300 EED H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 CREBBP DAD1 LCK IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 ERLEC1 PSMD8 RBBP4 RBBP5 PSMD6 PSMD7 CSK PSMD2 NFE2L2 RBBP7 PSMD3 TCF7L2 PSMD1 H2AZ2 TCF7L1 BTRC PTPN11 SKP1 TNRC6C CD4 PTPN6 PDCD1 PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 JUN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L MYC TRBC1 PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B ATF3 RPN2 EPAS1 RPN1 HIF1A TRAV29DV5 HLA-DQA2 WWTR1 HLA-DRB5 H4C9 HLA-DRB4 JUND ERLIN1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation TFAM POLRMT TFB2M ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis EZH2 H2AX PAX6 ASH2L JUN H3-3B H3C8 H2AJ KMT2D H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 KDM6A H2BC1 POLR2A POLR2B POLR2C H2AB1 POLR2D POLR2E RXRA POLR2F RARG POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 RARA POLR2J POLR2K POLR2L CNOT6 KMT2C EGR2 HOXA2 HDAC3 CNOT9 RARB H2AC19 H2AC14 H2BC12L PAXIP1 DPY30 H2BC26 H2BC21 WDR5 EP300 EED H2BC17 HOXB4 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP CTCF NCOA6 PCGF2 PAGR1 H2BC11 HOXA3 HOXA1 PKNOX1 HOXA4 NCOR1 NCOA3 PIAS2 HOXB3 H4C9 HOXB2 RBBP4 HOXB1 RBBP5 YY1 AJUBA HOXD1 HOXC4 RBBP7 PBX1 MEIS1 H2AZ2 MAFB H2AC20 HOXD4 HOXD3 ZNF335 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein POM121C NUP42 NUP62 RCC1 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NPM1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ14 KCNJ12 KCNJ2 KCNJ4 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism MTMR10 TNFAIP8 MTMR12 PITPNB MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 INPPL1 SBF2 TPTE2 RUFY1 INPP4A INPP4B INPP5D PI4K2A INPP5J PIP4K2A VAC14 PIP4K2B MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 SYNJ1 GDPD3 TPTE GDPD5 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 FIG4 PIKFYVE PI4KB PNPLA6 PI4K2B MTMR2 SACM1L RAB4A PI4KA ARF1 SBF1 PTPN13 PIP4P1 RAB5A PTEN MTMR4 PIK3R4 PIK3CD PIK3CB PIK3CG PIP5K1C SYNJ2 INPP5E PIK3R3 PIK3C3 PIK3R2 PIK3CA PIK3R1 PIK3R6 PIK3C2A PIK3R5 OCRL RAB14 ARF3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 LYN EPO STAT5A STAT5B IRS2 JAK2 EPOR SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 ITPK1 PPIP5K2 IP6K1 NUDT3 IP6K3 NUDT4 IPPK NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes ATF4 EP300 MAFK NFE2L2 CREBBP SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP GDF2 SMAD6 SMAD9 SMAD5 SMAD7 GREM2 INHBA ZFYVE16 BMPR1B ACVR2A BMPR1A TGFBR3 UBE2D1 INHA SKI BMP2 UBE2D3 ACVRL1 BMP10 SMAD1 BMPR2 SMAD4 AMHR2 FSTL1 CHRDL1 SMURF2 ACVR2B AMH CER1 SMURF1 NOG GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling GGT3P GGT5 GCLC OPLAH GCLM CNDP2 CHAC2 CHAC1 GGCT GGT7 GSS GGT6 GGT1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System SYT10 PRKAG1 PRKAG2 PRKAG3 RAC1 MDM2 KCNK6 KCNK7 KCNK1 SRC NRAS MAPK1 GRIN2B HRAS MAPK3 HOMER3 EPB41 CHRNA1 STXBP1 CHRNB2 EPB41L5 CHRNB4 EPB41L2 CHRNA3 HOMER1 CHRNB3 HOMER2 CHRNA2 PPFIBP1 CHRNA5 PPFIBP2 CHRNA4 PTPRS CHRNA7 PTPRF CHRNA6 SIPA1L1 CHRNA9 DLGAP1 CHRND DLGAP3 CHRNG DLGAP2 CHRNE DLGAP4 BEGAIN APBA3 APBA2 LRRC4B SYT7 PTPRD LRFN3 LRFN2 LRFN4 LRFN1 LRRTM3 LRRTM4 KCNJ8 LRRTM1 ABCC8 PDPK1 SYT9 LRRTM2 IL1RAPL2 IL1RAPL1 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 GIT1 NLGN2 NRXN1 NRXN3 PRKAA1 NRXN2 PRKAA2 SLITRK2 SLITRK1 SLITRK4 SLITRK6 PDLIM5 NLGN4Y NLGN4X SYT12 SLITRK3 SLITRK5 CALM1 AP2A1 PRKACG PRKACB GLS SLC1A1 SLC1A2 RPS6KA1 SLC1A3 SLC6A3 SLC1A6 SLC5A7 SLC1A7 SLC38A2 SLC38A1 SLC6A12 GNGT1 GNGT2 GNAT3 ADCY9 PRKAR1B PRKAR2B GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ACTN2 ADCY8 GNG10 GRIN2C ADCY7 PRKAR2A ADCY6 PPM1E GNG3 GNAI1 PPM1F GRIN2D ADCY5 GNG2 GNAI2 GRIN1 GRIN2A GNG5 DLG2 GNG4 LRRC7 GNG7 CAMK4 GNG8 NEFL CAMK1 AKAP5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 MYO6 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 KCNN1 KCNN3 GNB2 KCNN4 KCNF1 GNB1 KCNC1 GNB4 KCNK9 KCNC2 GNB3 KCNC3 GNB5 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNMB1 RTN3 KCNA10 KCNMA1 HCN4 HCN3 KCNN2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNQ2 KCNA7 KCNQ3 GAD1 KCNJ1 KCNB1 GAD2 KCNB2 KCNJ14 KCNS1 DBNL KCNS2 KCNS3 KCNK2 HCN2 KCNK3 HCN1 KCNK4 GJC1 PANX1 GJD2 PANX2 GJA10 SNAP25 SYT2 SYT1 VAMP2 STX1A KCNQ4 EPB41L3 GRIP1 RPS6KA6 NSF PRKCG CASK GABRG3 KPNA2 HSPA8 GABRG2 GRIP2 GRIA1 LIN7A LIN7C LIN7B ABAT EPB41L1 ARL6IP5 TSPAN7 GLUL GRIA3 UNC13B GRIA4 CACNA2D1 GRIN3B SLC6A13 GNAL CACNA2D3 GRIN3A CACNA2D2 NBEA SLC6A11 GABRB3 SLC22A2 GABRB2 COMT SLC22A1 GABRB1 ACHE RASGRF2 SLC6A1 RASGRF1 KIF17 SLC6A4 SLC18A2 NRGN GABRR3 SLC18A3 GABRR2 SLC32A1 DLG1 GABRR1 SYN3 DLG3 SYN2 DLG4 NPTN GRIK5 SYN1 HTR3E GRIK3 ALDH5A1 HTR3C GRIK4 SLC17A7 HTR3D GRIK1 BCHE HTR3A GRIK2 RAB3A NRG1 RIMS1 HTR3B NCALD ARHGEF9 PPFIA1 PICK1 PPFIA4 CAMKK1 PPFIA3 CAMKK2 PPFIA2 GLRA1 CACNB1 GLRA2 CACNB2 CACNB3 FLOT1 CACNG8 GLRA3 CACNB4 NAAA CACNG2 TOMT FLOT2 CACNG3 CHAT KCNJ2 CACNA1B CACNG4 CACNA1A KCNJ3 GABRA2 CACNA1E GABRQ CPLX1 DNAJC5 KCNJ4 GABRA1 GLS2 TSPOAP1 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GABRA6 GABRA5 KCNJ12 KCNJ9 GABRA4 GABRA3 KCNJ15 KCNJ16 GLRB APBA1 PRKCB GRIA2 ALDH2 NTRK3 SHARPIN PRKACA ABCC9 PRKCA PLCB3 PLCB1 PLCB2 CAMK2B CAMK2D CAMK2A MAOA PRKAR1A PRKAB2 CAMK2G KCNJ11 PRKAB1 GRM1 GRM5 RPS6KA3 RPS6KA2 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 RXRB PLIN1 RXRA NR1H3 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives GPX1 ALOX15 GPX4 ALOX12B ALOX12 ALOXE3 GPX2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape H2AX H3-3B TBP H3C8 H2AJ RRN3 H3C15 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CCNH H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 UBTF H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 H2AZ2 H2AC20 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle NISCH CPD KCTD13 PKP4 PLEKHG5 EPHA2 RASAL2 ARHGAP21 MUC13 KTN1 VANGL1 ROCK1 DDX4 FLOT2 SCRIB PIK3R2 PIK3R1 PICALM TMOD3 DSP TXNL1 ARHGAP5 ARHGAP35 DSG1 WDR6 FAM83B RBMX ANKRD26 DST CAV1 TNFAIP1 PTPN13 CCDC88A RND3 LEMD3 CKB VANGL2 SEMA4F DEPDC1B UBXN11 CKAP4 DLG5 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib HSP90AA1 CDC37 ERBIN ERBB2 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins FURIN PCSK6 PCSK5 NGF FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 SAA1 FPR2 HEBP1 APP FPR1 ANXA1 FPR3 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAA2 PRKAB1 PRKAG1 PRKAG2 PPARGC1A MAPK14 PRKAG3 PRKAB2 MAPK12 MAPK11 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ATM H2AX HERC2 UBA52 CHEK2 UBB UBC RPS27A MAPK8 H2BC9 H3-4 PIAS4 H2BC8 H2BC5 ABL1 H2BC3 UBE2I H2BC1 BRCC3 SUMO1 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 NBN H2BC12L SMARCA5 PPP5C H2BC26 UBE2V2 BAP1 UBXN1 H2BC21 BAZ1B APBB1 UBE2N KDM4A MDC1 H2BC17 EYA1 EYA2 H2BC12 H2BC13 EYA3 H2BC14 EYA4 H2BC15 H2BC11 BARD1 H4C9 KDM4B RAD50 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA DBT BCKDHB LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome WDR5 RBBP5 ASH2L DPY30 KMT2D STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation STAT5A STAT5B GAB2 FLT3LG FLT3 PTPN11 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle CDC14A AURKA PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 RB1 PSMC1 PSMC2 FZR1 SKP2 CDK2 NEK2 BUB1B CDC20 FBXO5 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC AURKB SKP1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 CPSF1 NUP85 CPSF4 CPSF3 EIF4E CPSF2 WDR33 NUP37 FIP1L1 SYMPK SEC13 NUP133 SLBP NUP205 POM121 NUP107 NUP188 AAAS SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins IL6 JAK1 CXCL8 H3C8 FOS VAV1 MAPK9 H3C15 MAPK8 MAPK7 PAK2 MAPK10 STAT1 STAT3 CD86 BCL2 CD80 BCL2L1 MAP3K8 LCN2 TBK1 NFKB2 HGF PIK3CD PIK3CB ALOX5 PTGS2 IL1RAPL1 IL7R PIK3CA LCK CDC42 FYN PTPN11 IL32 CD4 PTPN6 CNTFR CNTF IL20RA IL20RB CSF3 IL22RA2 IL1RN IL31RA TNF IL22RA1 IL12B TOLLIP IL12A HAVCR2 IL10RB CTF1 IL1R2 IL10RA CLCF1 IL13RA2 LIF IL13RA1 TNFRSF1B FSCN1 TNFRSF1A FCER2 NDN MCL1 IL21R IL36A IL36B LGALS9 IL15RA IL36G IL1F10 IL21 IL22 IL20 IL25 IL26 STXBP2 IL24 IL11 IL15 IL19 HCK IL17RE OSMR IL17RB RHOU IL33 MAP3K3 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IFNL2 IL1RL2 PTK2B P4HB IFNL3 NOS2 CISH F13A1 SOCS2 CFL1 CTSG SYK TP53 TALDO1 IGHG4 IGHG1 IL10 TIFA TCP1 ALPK1 SDC1 HNRNPA2B1 IL17F IL17A IL1R1 GATA3 BLNK IL2RG JAK3 INPPL1 MMP9 INPP5D TYK2 S1PR1 STAT2 COL1A2 HNRNPF SNRPA1 CEBPD TGFB1 IL17RC IL17RA RPLP0 HSP90AA1 PSMD8 RORC IKBKB CANX PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 MTAP PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 PSMA7 MYD88 RELA PSMB6 PSMB7 PSMB4 PSMB5 ATF1 UBB PSMB2 PSMB3 NKIRAS1 NKIRAS2 UBC IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 SEM1 IRAK4 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 LRRC14 PSMC1 PSMC2 USP14 NLRX1 FOXO1 PELI3 PELI2 NFKBIB SOCS3 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 RORA S100B TNIP2 SAA1 ALOX15 PTPN18 IL37 PTPN20 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 CD36 IRAK3 IRF4 MAOA SOX2 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CCL2 IL2RA LAMA5 SOD1 PTPN4 FN1 CBL PSME2 RALA SHC1 CRKL MAPK1 SMARCA4 MAPK3 MAP2K1 IL4 IL18RAP MAPK14 IL13 IL6ST MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 RAG2 CRK RAG1 UBE2V1 TSLP IL7 BRWD1 CRLF2 ATF2 VEGFA ICAM1 ZEB1 RPS6KA5 HMOX1 UBE2N TAB3 TAB2 TAB1 ITGB1 IRAK1 MEF2C IL2 IL3 VCAM1 TRAF6 IGHE PPIA CCR5 NANOG APP JUN FASLG SOD2 FOXO3 IL34 IL16 CSF1 IFNLR1 LMNB1 IFNL1 TXLNA PTPRZ1 PRTN3 JUNB STX3 RPS6KA1 RBX1 YWHAZ POMC ITGAM ITGB2 ITGAX ANXA2 GSTA2 CA1 STAT5A STAT5B PIM1 GRB2 POU2F1 SOS2 VIM FPR1 CSF2 MMP2 CCL11 CCL19 CCL22 MSN CCL20 SNAP25 CSF1R ELK1 CDKN1A CXCL10 VAMP2 STX1A CCND1 ANXA1 SQSTM1 CCL5 ARF1 CCL4 CCL3 PTPN12 HSPA8 PPP2R1B VAMP7 PPP2R1A SOCS5 BCL6 GSTO1 CCR1 IRS1 IRS2 FGF2 CCR2 HMGB1 CASP8 GAB2 OPRD1 CASP1 MUC1 IL18 IL9 PPP2R5D TRAF2 IL9R IL1A IL1B PELI1 BIRC5 CSF3R IL6R CCL3L3 GSDMD PPP2CA PPP2CB CXCL1 CXCL2 TWIST1 HSPA9 TEC LIFR CASP3 STX4 PTAFR SMAD3 CAPZA1 TIMP1 PRKACA OPRM1 IFNG MYC AKT1 HSP90B1 MMP3 PIK3R3 LBP PIK3R2 PIK3R1 HIF1A RAP1B SOCS1 JAK2 LYN RPS6KA3 RPS6KA2 MAP2K3 YES1 MAP2K4 STAT6 MAP2K7 MAP2K6 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CUL3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 DVL1 PSMC3 DVL2 PSMC4 DVL3 PSMC1 PSMC2 PSMD8 KLHL12 PSMD6 HECW1 PSMD7 PSMD2 PSMD3 PSMD1 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins POM121C NUP42 NUP62 RCC1 NUP43 TPR NUP88 RANBP1 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NPM1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 XPO1 NUP37 SEC13 NUP133 RANGAP1 NUP205 POM121 NUP107 NUP188 AAAS LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CTNNB1 LRRFIP1 EP300 IRF3 CREBBP RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle RAC1 MTMR1 TFRC VAV1 SCFD1 ATP6AP1 PAK1 PAK3 PAK2 DOCK3 FRS3 TIAM1 HMOX2 JAG1 VCP ITSN2 DBT RTKN SOWAHC ARHGEF10L STK10 AKAP13 SLK ARHGEF11 ARHGEF10 NCKAP1 ARHGEF12 NCF1 ARHGEF17 STARD8 NCF2 NCF4 RHOB CIT SNAP23 DAAM1 BRK1 ARHGAP6 ARHGEF3 ARHGEF1 DOCK10 ARHGEF2 SYDE1 PKN3 ARHGAP42 PIK3CA BAIAP2L1 ARHGEF25 PICALM RAC3 ARHGEF28 IQGAP3 LCK GIT1 SWAP70 STOM RHPN2 ARAP2 CYBB ECT2 STARD13 ARAP3 JUP OCRL CAVIN1 CYBA BCR CDC42 PCDH7 AMIGO2 MYO9A NET1 NOXO1 ANLN ARHGAP17 ARHGAP15 DIAPH1 ABR CSK ACTC1 RACGAP1 DLC1 PKN2 SLITRK3 PKN1 NHS TNFAIP1 SLITRK5 RND3 NCKAP1L CKB WASF1 SEMA4F WASF2 ARHGEF40 CKAP4 NISCH PLEKHG2 IL32 KCTD13 GIT2 ARHGEF15 PLEKHG5 TRIP10 ARHGAP26 BAIAP2 ARHGEF19 TAOK3 RHOC ABI2 TIAM2 OBSCN NOXA1 ABI1 ARHGEF4 NOX3 ARHGEF7 NGEF NOX1 FERMT2 ARHGEF6 FGD1 C1QBP FGD2 GNA13 FGD3 FGD4 ARHGEF39 PLXNB1 SLC1A5 RHOU GJA1 ACTB PTK2B CYFIP2 WIPF1 WIPF2 WDR91 WIPF3 ANKFY1 WDR81 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 FGD5 CHN2 WASL CHN1 FARP1 DEF6 WDR11 VMA22 WAS SHKBP1 GOPC FILIP1 FAM13B CCT6A FAM13A POTEE GOLGA8R RALGAPA1 FAM91A1 TEX2 ARMCX3 DDRGK1 TUBA1B NSFL1C ARHGAP11A ZNF512B ARHGAP11B TAGAP CCT2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 BLTP3B SH3BP1 WHAMM GOLGA3 BAIAP2L2 SPATA13 TMEM87A FAF2 AKAP12 HINT2 GRB7 SH3PXD2A STMN2 RHOH KIF14 RHOF RHOD RND1 STIP1 RHOV EPSTI1 PLEKHG4B WDR6 EMC3 CCT7 PLXNA1 PRAG1 PLXND1 WASF3 SYDE2 FAM83B ANKRD26 ARHGAP44 DST DOCK11 RRAS2 BCAP31 ARHGAP40 BASP1 ALDH3A2 TMEM59 RALBP1 CCDC88A KCTD3 PREX2 FAM135A ARHGAP45 VANGL2 ARHGAP19 ARHGAP18 UBXN11 AAAS TOR1AIP1 DLG5 CPD ARHGAP12 WWP2 PKP4 ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 RASGRF2 USP9X ARHGEF9 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 FMNL3 HSP90AA1 ARHGAP39 SRGAP3 SRGAP2 SRGAP1 DOCK7 SENP1 SRRM1 PTPN13 DDX39B CCP110 CEP97 ARHGAP10 SRC STAM HGS STAM2 FARP2 PLD2 KIDINS220 FRS2 RAPGEF1 SOS1 PARD6B ARHGEF18 RHOA PARD6A PGRMC2 ARL13B DDX4 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L CFTR ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 RAB7A EPHA2 VAMP3 ARHGEF26 GARRE1 SHMT2 PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 LMNB1 STX5 YKT6 PAK4 NDUFA5 MCF2 MCAM ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 ABCD3 RAC2 CAV1 VAV3 VAV2 UACA HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 PAK6 MSI2 PAK5 RHOBTB1 MYO9B ACTG1 RHOBTB2 TRA2B MYO6 ABL2 STK38 RBBP6 RNF20 SPEN CPSF7 TMOD3 NCK2 ACTN1 NCK1 TXNL1 COPS4 COPS2 CDC37 PHIP SOS2 PDE5A VIM HNRNPC RBMX DBN1 CUL3 RASAL2 SPTBN1 LAMTOR1 SPTAN1 TPM4 TPM3 MTR MUC13 LBR FLOT1 NUDC FLOT2 SAMM50 MTX1 SH3RF1 STEAP3 DSP DSG1 DSG2 CAPZB TJP2 PIK3R3 IQGAP1 PIK3R2 PIK3R1 ZAP70 MAP3K11 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance ALDOB MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A SGSH REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane FURIN POMT1 PCSK6 TMEM258 SEC11A MOGS SEC11C ANK3 OST4 OSTC STT3A CSNK2A3 ARHGAP32 PIP5K1C CSNK2A1 CDH1 CSNK2A2 CSNK2B CTNNB1 PCSK7 RPN2 DDOST SPCS3 RPN1 SPCS2 SPCS1 DAD1 JUP PRKCSH CANX POMT2 GANAB NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors P2RY10 LPAR6 P2RY11 ADORA3 ADORA1 P2RY6 ADORA2A P2RY2 P2RY4 P2RY1 ADORA2B P2RY12 LPAR4 P2RY13 GPR17 P2RY14 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes SYT10 ARNT INS ARNT2 CREBBP NAMPT RBFOX3 BDNF NPAS4 MDM2 IQSEC3 MAPK1 CDK5 MAPK3 FOS BMAL1 CDK5R1 RET XPO1 PLK2 GEM DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A1 MAN1A2 MAN1C1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ECI1 HADHA ACADM ACADL DECR1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HIF1A HBEGF EGFR PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs RAB7A YWHAE TRAPPC2L SBF2 TRAPPC6A TRAPPC6B RAB1A ALS2 RAB1B RAB6A RAB6B RIC1 RGP1 RAB8A RAB9A TRAPPC2 RAB9B TRAPPC3 TRAPPC1 RABGEF1 TRAPPC10 RAB27B DENND1C TRAPPC4 DENND1B TRAPPC5 GDI1 TRAPPC9 DENND5B DENND1A GDI2 RINL TRAPPC12 TRAPPC11 RAB8B DENND5A TRAPPC13 DENND2D DENND2C SBF1 DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 RAB35 DENND6A RIN1 RIN2 ULK1 DENND3 RAB7B RAB21 ALS2CL CHM CHML ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB27A RAB39B TRAPPC8 RAB12 RAB18 RAB5B RAB3GAP2 RAB5C RAB3GAP1 MON1A MON1B RAB5A GAPVD1 AKT2 AKT3 AKT1 RAB3A RAB10 RAB14 RAB13 RAB3IP GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNGT1 GNGT2 GNAT3 GABRG3 ADCY9 GABRG2 GNAI3 GNAL ADCY4 GABRB3 ADCY3 GABRB2 GABRB1 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 GABRR3 GNAI1 GABRR2 ADCY5 GNG2 GABRR1 GNAI2 NPTN GNG5 GNG4 GNG7 GNG8 ARHGEF9 KCNJ2 KCNJ3 GABRA2 GABRQ KCNJ4 GABRA1 GABBR2 KCNJ5 KCNJ6 GABBR1 KCNJ10 GNG12 GABRA6 GNG11 GABRA5 GNG13 KCNJ12 KCNJ9 GNB2 GABRA4 GABRA3 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation CHUK PPP2CA PPP2CB FBXW11 JUN UBA52 CUL1 RIPK2 RPS6KA1 FOS ATF1 UBB UBC MEF2A RPS27A DUSP4 DUSP3 NFKB1 VRK3 MAPK9 DUSP6 MAPK8 DUSP7 MAPK7 ELK1 MAPK10 NOD1 NOD2 IRAK2 MAPK1 MAPK3 TNIP2 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 RPS6KA5 UBE2N TAB3 TAB2 TAB1 IRAK1 PPP2R5D MEF2C RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion HSD17B10 TRNT1 ELAC2 TRMT10C PRORP ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSME2 PSMA5 PSMB10 PSMA6 PSMA3 PSMA4 PSMB8 PSMA1 PSMB9 PSMA2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME1 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction RAPGEF1 SOS1 RASA1 CRK PDGFRA SRC PIK3CB PDGFRB BCAR1 PDGFB STAT5A STAT5B PIK3R2 PIK3R1 PIK3CA NCK2 GRB7 NCK1 CRKL NRAS STAT1 STAT3 HRAS PLCG1 STAT6 PTPN11 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS MAPKAPK3 MAPKAPK2 SOS1 RALA SHC2 RALB SHC3 SHC1 NRAS HRAS RALGDS NTRK1 MAPK14 NGF MAPK12 MAPK13 MAPK11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRB3 ADRA2C ADRA2B ADRA2A ADRB1 ADRB2 ADRA1D ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes EP300 MAFK NFE2L2 CREBBP CCL2 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes H2AX ASH2L CCNC MEN1 PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 CXXC1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2A KMT2C GPAM SCD ADIPOQ HDAC3 KAT8 PHLDA1 ACSL1 HCFC2 WDR82 PEX11A BOD1L1 DPY30 MBIP TASP1 KAT14 H2BC26 DR1 H2BC21 BOD1 CIDEC WDR5 TADA2A EP300 ZZZ3 YEATS2 TBL1X TADA3 H2BC17 AKAP8L SGF29 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 PHF20L1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 KANSL1 CREBBP KANSL2 KANSL3 NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 MCRS1 PDK4 PHF20 OGT ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL KMT2B LIPE DGAT2 MED30 SETD1B MED31 SETD1A KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 KAT2B KAT2A H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 HCFC1 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 PSIP1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol CYP8B1 NCOA1 NCOA2 AKR1C3 HSD3B7 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP7A1 CYP27A1 RXRA ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) LYN EPO PLCG2 PLCG1 IRS2 JAK2 EPOR REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death TNFRSF10B TNFRSF10A ITCH FAS FASLG UBA52 STUB1 OGT UBB MLKL UBC RPS27A TRADD UBE2L3 CASP8 FLOT1 TNFSF10 FLOT2 PDCD6IP RIPK3 TRAF2 HSP90AA1 CDC37 PELI1 BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 FADD TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade PTPN4 UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 DNM1 MAPK10 DNM3 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 DNM2 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 RIPK3 PPP2R5D MEF2C TRAF2 PELI1 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 ECSIT IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 ITGAM ITGB2 SIGIRR BTK PLCG2 S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 CD180 LY86 LBP BPI SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PPIA ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation CFD C3 CFB GZMM DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency TCN2 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway DUSP16 PPP2CA PTPN7 PTPN3 PPP2CB PPP2R1B PPP2R1A UBA52 UBB PPP5C UBC RPS27A DUSP4 PPP2R5E DUSP6 DUSP7 ARAF PEBP1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C YWHAB BRAP MARK3 NRAS KSR1 MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 RAF1 DUSP10 DUSP5 BRAF DUSP2 DUSP1 PAQR3 MAPK12 DUSP8 DUSP9 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) MYD88 TLR5 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis ALAS2 ALAS1 FECH COX15 UROS CPOX PPOX ALAD UROD HMBS ABCG2 COX10 ALB DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses IFIH1 EXOC1 TRIM25 DDX3X MAVS VTN CDC73 SKIC8 STAT2 CTR9 RTF1 IKBKE HSP90AB1 LEO1 PAF1 UBR4 MBL2 C4A C1QA C4B_2 C1S RBM10 APOA1 CGAS HSP90AA1 CLEC5A C4BPA C4BPB CLU STING1 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance PCSK9 AP2A1 APOB LIPA AP2S1 AP2A2 LDLR CLTC LDLRAP1 CLTA AP2M1 AP2B1 NCEH1 LSR NPC1 SOAT1 SOAT2 NPC2 CES3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PRICKLE1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 WNT5A SMURF2 SMURF1 PARD6A FZD1 FZD3 FZD2 DVL2 FZD5 FZD4 SCRIB FZD7 FZD8 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VANGL2 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins PHC2 PHC1 CBX4 CBX2 PHC3 DNMT3B PCGF2 DNMT3A DNMT1 UBE2I BMI1 RING1 SUMO1 CBX8 RNF2 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 GALNT1 DCTN2 DCTN3 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNC1H1 ACTR1A PLA2G4A RAB18 DCTN6 RAB3GAP2 DCTN5 RAB3GAP1 DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 GALNT2 PAFAH1B2 RAB6A RAB6B DCTN1 DYNLL1 AGPAT3 DYNLL2 CAPZB PAFAH1B1 DYNC1I2 CAPZA1 CAPZA2 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development RAC1 TEAD1 YAP1 PAK1 MAPK7 PAK3 PAK2 GAB1 GRIN2B TIAM1 PLCG1 ADAM10 GSK3B PIK3CD CLTCL1 PIK3CB PIP5K1C ARHGEF11 ARHGEF12 RHOB SHANK3 PIK3CA ARHGEF28 GIT1 COL4A2 COL4A1 COL6A2 COL4A4 CDC42 COL6A1 COL4A3 FYN COL9A1 COL6A3 PTPN11 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 AP2A1 RHOC AP2A2 ARHGEF7 PRKACG NGEF PRKACB ELOB AP2M1 ELOC NCBP1 NCBP2 PLXNB1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B AP2S1 AP2B1 ACTB ARPC1B ARPC1A CFL1 WASL SDC2 GRIN1 MYH9 ARPC4 ARPC5 ARPC2 ARPC3 GRB7 ACTR3 ACTR2 RND1 PLXNA1 PLXND1 MYO10 MYL9 GPC1 MMP9 AGRN RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPS6KA6 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 EGFR RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 PSMD14 ARHGAP39 PSMD13 SEMA4D SLIT2 SRGAP3 LIMK2 PSMA7 SRGAP2 LIMK1 SRGAP1 RRAS ROBO1 MYH14 PSMB6 MYH10 PSMB7 PSMB4 PSMB5 DPYSL4 UBB DPYSL5 PSMB2 DPYSL3 PSMB3 UNC5C UBC UNC5D PSMB1 AGAP2 RPS27A DSCAML1 ADRM1 PLXNC1 SEMA6A SEM1 SEMA6D PSMC5 UTRN PSMC6 SEMA7A PSMC3 RAP1GAP PSMC4 PLXNA2 PSMC1 MBP PSMC2 PLXNA3 PTPRC PTPRA PLXNB3 TREM2 ADGRV1 SEMA3A NTN4 SEMA3E EIF4A3 CASC3 ABLIM1 ABLIM2 ABLIM3 MAGOH SEMA4A ARTN PRX GFRA3 RGMB GFRA2 RGMA GFRA4 DRP2 CD72 SCD5 MPZ NRTN DSCAM DOK1 DOK2 TYROBP DOK4 DOK5 DOK6 ADGRG6 CACNA1S RBM8A PRNP PSPN HJV PRKCA CRMP1 HMGCR PDLIM7 PMP22 UPF3B MAGOHB RNPS1 POU3F1 PITPNA ITGA5 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 LAMA2 LAMA1 NEO1 LAMB1 LAMC1 SH3KBP1 SRC MET SH3GL2 SHC3 SHC1 NRAS FARP2 MAPK1 HRAS SMARCA4 MAPK3 MAP2K1 MAP2K2 FRS2 PRKCQ SOS1 RHOA GFRA1 RPS6KA5 GDNF ITGB1 TRIO ITSN1 ARHGAP35 LDB1 PPP3CB DOCK1 EPHA1 EPHA2 KALRN UNC5A PAK4 CDK5 RPS6KA1 UNC5B CDK5R1 POU3F2 RBX1 SOX10 RET VAV3 ITGAV PTK2 EGR2 DAG1 HOXA2 ISL1 PFN1 VAV2 PFN2 GSPT2 GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 AKAP5 ZSWIM8 PAK6 PAK5 CAP2 MYO9B ACTG1 MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 EPHB6 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 RPS6KA4 EPHA3 ALCAM ITGA2B EPHA10 SCN11A EFNA5 DPYSL2 EFNA4 SCN9A EFNB2 NRCAM EFNB1 EPHB2 EFNB3 SCN1B EFNA1 RASA1 SCN1A EFNA3 ANK2 EFNA2 ANK3 ANK1 SHTN1 SCN10A SCN8A KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 NCAN ST8SIA4 SPTA1 MAG SCN3B SCN3A SPTBN1 NAB1 SPTBN2 NAB2 CNTN6 RDX MSN L1CAM ST8SIA2 KIF4B KIF4A ITGA10 CNTN1 EIF4G1 CNTN2 CD24 SCN2A CACNA1H MYL12A SCN2B NRP2 CNTNAP1 MYL12B CHL1 CACNA1G CACNA1I SCN5A SPTAN1 LYPLA2 SPTB MYH11 DNM1 DNM3 GAP43 DCX ABL1 NUMB SCN4A SCN4B ITGA9 SCN7A NCAM1 RANBP9 CLTB NFASC SREBF2 MYL6 PLXNA4 SEMA5A HSPA8 DNM2 CYP51A1 DLG1 DLG3 CACNA1C DLG4 IRS2 RPS27 CACNB1 CACNB2 CACNB3 GAB2 CACNB4 HDAC2 ITGA2 ITGA1 SDCBP CLASP1 CLASP2 RELN DAB1 VLDLR SIAH2 SIAH1 FES CACNA1D PRKACA ERBB2 CSNK2A1 CSNK2A2 CSNK2B ITGB3 PIK3R3 PIK3R2 PIK3R1 GRB10 LYN RPS6KA3 RPS6KA2 WWTR1 YES1 TLN1 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance PPP6C ACD H2AX PPP6R3 LIG1 H3-3B TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP ANKRD28 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 DAXX ATRX H2BC1 GAR1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 KNL1 NPM1 TERT H2BC26 H2BC21 DKC1 H2BC17 NHP2 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RUVBL1 NOP10 RBBP4 ITGB3BP RBBP7 H2AZ2 CENPA CENPC CENPT CENPU PRIM2 CENPH PRIM1 CENPI POLA1 HJURP POLA2 CENPK RSF1 CENPL MIS18BP1 CENPM OIP5 CENPN CENPW CENPX CENPO MIS18A CENPP CENPQ CENPS FEN1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L DSCC1 RUVBL2 SHQ1 PIF1 H2AC19 CHTF8 H2AC14 CTC1 RFC5 H2BC12L CHTF18 RFC3 WRAP53 STN1 RFC4 TEN1 SMARCA5 RFC1 RFC2 DNA2 BLM RTEL1 PCNA POLD3 POLD4 WRN POLD1 POLD2 H4C9 TINF2 RPA1 RPA2 H2AC20 RPA3 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways CD3G RAC1 IL6 VAV1 MAPK8 IGHV3-23 IGLV IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 ADAM17 IGHV4-59 IGHV1-69 IGLV2-11 NFKB2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 HMOX1 C3 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 CYBA V1-7 V5-1 CDC42 V1-5 NOXO1 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 IGLV3-27 ELMO2 IGKC IGLV3-21 DOCK1 BAIAP2 CALM1 IGKV1-39 ABI2 IGKV1-33 V4-6 NOXA1 ABI1 IGHV3-53 JUN V4-2 PRKACG NOX1 IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK ELMO1 GNGT1 GNGT2 ACTB CYFIP2 WIPF1 WNT5A WIPF2 WIPF3 GNAT3 C3AR1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK MEFV PRKAR2B PLCG2 MYO5A ARPC1B ARPC1A VAV3 WASL CTSG PTK2 SYK GNAI3 ADCY4 WAS ADCY3 VAV2 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 NT5E GNG5 PYCARD GNG4 IGHG3 GNG7 IGHG4 GNG8 IGHG1 HSP90AB1 CYSLTR1 IL10 IGHG2 CYSLTR2 CD163 PLK2 GGT1 DPEP2 RHBDF2 DPEP1 MYH9 MYO9B ACTG1 GNAZ NCKIPSD DVL1 DVL2 DVL3 NLRP3 GGT5 FZD7 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 NCK1 FCGR3A ACTR3 ACTR2 FGR MYH2 GNG12 ADORA2B GNG11 FCGR1A GNG13 WASF3 MYO10 GNB2 P2RX7 P2RX4 TXNIP GNB1 FCGR2A GNAS MYO1C GNB4 SUGT1 GNB3 GNB5 FURIN ABL1 CASP1 IL18 IL1A IL1B GSDMD RELA NFKB1 AHCYL1 PRKACA ITPR1 ITPR2 ITPR3 PRKAR1A LYN YES1 TXN IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TBK1 IRF3 NLRP4 MRE11 DTX4 DDX41 PRKDC NLRC3 IFI16 XRCC6 XRCC5 TREX1 STING1 AGGREGATED Î’-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis F12 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors HCRTR2 QRFPR QRFP HCRTR1 NPFFR2 NPFFR1 HCRT NPFF NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly PPP2CA NUP62 RCC1 NUP43 BANF1 CHMP2B CHMP2A NDC1 NUP155 RAN NUP93 CCNB1 LMNB1 NUP35 NUP54 CDK1 TNPO1 SPAST CC2D1B SIRT2 TUBB8 IST1 NUP37 VRK1 LEMD2 TUBB8B UBE2I TUBB6 TUBB3 TUBB1 NUP107 SUMO1 PPP2R1A TUBA4B PPP2R2A TUBA4A NUP160 KPNB1 CCNB2 TUBA8 NUP85 TUBA1C TUBA1B TUBA1A LBR TUBB2B AHCTF1 TUBB2A SEC13 ANKLE2 NUP133 TUBAL3 TUBA3E VPS4A RANGAP1 TUBA3D TUBA3C CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 EMD CHMP7 TUBB4B TUBB4A NUP205 LEMD3 POM121 NUP188 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC3H APOBEC4 A1CF ADAR APOBEC3A APOBEC3B ADARB1 APOBEC1 APOBEC3C APOBEC2 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD ABCA1 APOA1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) MSH2 MSH3 PMS2 MLH1 PCNA LIG1 POLD3 POLD4 EXO1 POLD1 POLD2 RPA1 RPA2 RPA3 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception CHRNA9 LRP2 CLPS PNLIP APOA2 APOA4 LPL LDLR GPIHBP1 OPN1MW APOC3 APOC2 GNAT3 ADCY3 HSPG2 SDC4 SDC2 SDC3 MYH9 SDC1 MYO1C FNTA FNTB KCNMB1 KCNMA1 CHRNA10 KCNN2 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 USH1C ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 CASK GSN WHRN LHFPL5 OTOGL TMIE USH1G STRC EPB41L1 MYO15A SLC26A5 GNAL KCNJ2 AKR1C1 AKR1C4 SLC24A1 RHO SAG CNGA1 GNAT1 CNGB1 AKR1C3 PRKCA DHRS3 PLCB2 PDE6B DHRS9 PDE6A RDH11 PDE6G RDH10 RDH16 RDH5 OR11H2 OR11H1 OR2M7 OR11H4 SCNN1G OR2M5 SCNN1D OR2M4 SCNN1B OR2M3 SCNN1A OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 LRAT OR11H7 TRPM5 OR2L8 OR2L5 OR11G2 TRPM4 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 RBP4 RBP2 OR4K15 RBP3 OR4K14 OR4K13 RBP1 RETSAT OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 ANO2 OR5M10 RDH12 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 CNGA2 OR10J3 OR10J5 CNGA4 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 APOE OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 GUCA1B GUCA1A GUCA1C OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 PRKCQ OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 NMT2 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 PPEF1 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OPN1SW OR1Q1 OR51S1 OR4A47 STRA6 OR5B21 OR1P1 REEP1 OR13A1 APOB OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 RLBP1 OR56B1 OR2Y1 OR8D4 OR8D2 APOA1 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 LDB1 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 NMT1 OR10A5 LRP1 CALM1 OR6C65 LRP8 OR8B8 OR2W3 AWAT2 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 BCO2 OR12D2 BCO1 OR5AU1 RCVRN OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 METAP1 METAP2 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 GNGT1 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 OR52M1 ABCA4 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 PLB1 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 EBF1 OR52L1 APOM OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 RPE65 AKR1B10 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 TWF1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 LHX2 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 GNG13 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 GNB1 OR4A16 OR3A1 OR8K5 GNB3 OR8K3 GUCY2D OR8K1 HSD17B6 GUCY2F HSD17B1 OR4C45 SCN9A OR5AN1 OR4B1 SCN1B OR4C46 OPN1LW OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 EZR OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 SCN3A OR5K2 SPTBN1 OR51D1 OR5K1 OR6M1 RDX SDR9C7 OR2T12 MSN OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 SCN2A OR2D2 SCN2B OR52E4 SNAP25 OR5J2 OR52E2 OR52E1 OR2W5P SPTAN1 CAMKMT OR5AC2 RGS9BP VAMP2 OR5AC1 STX1A OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 SCN4B OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 TAS2R20 OR5I1 OR52D1 OR9Q2 OR9Q1 TAS2R10 GRK1 TAS2R13 CALHM1 TAS2R14 OR2AK2 TAS2R16 GRK7 OR51B6 OR51B5 OR51B4 TAS2R40 OR2B6 TAS2R41 OR4F6 OR5H6 TAS2R43 OR4F5 OR2B3 OR4F4 TAS2R46 OR2B2 OR10K2 OR10K1 OR4F3 CACNA2D2 OR5H2 OR5H1 OR6J1 TAS2R30 CALHM3 TAS2R31 OR2AJ1 OR51A4 TAS2R38 OR2A7 TAS2R39 OR51A2 LRP10 OR2A5 OR2A4 LRP12 SYN1 OR51A7 OR2A2 OR52J3 RTP2 RAB3A OR51H1 RTP1 OR8U9 TAS2R50 OR8U8 OR1G1 OR2I1 OR4M2 CACNB2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 CYP4V2 OR51G2 OR51G1 OR52I2 DNAJC5 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 TAS2R7 OR2G3 OR1E2 OR2G2 OR1E1 TAS2R8 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 GRM4 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 TAS2R1 OR1D5 TAS2R3 OR1D4 TAS2R5 OR1D2 TAS2R4 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 TAS1R2 TAS1R1 TAS1R3 TTR PCLO CAPZB BSN SYP CABP2 CACNA1D CABP1 LRRC52 OTOF SLC17A8 CAPZA1 CAPZA2 ITPR3 GRM1 ATP2B1 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation PPARG MTA2 PPARA PPARGC1B MBD3 GATAD2B GATAD2A UCP1 PPARGC1A HNRNPU NCOA1 MTA1 HDAC1 PRDM16 HDAC2 ZNF423 MTA3 ELOVL3 CIDEA EBF2 BMP7 CHD4 RBBP4 CHD3 COX7A1 RBBP7 SMAD1 SMAD4 RXRA NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway ESRRB ESRRG ESR2 RARA PGR NR4A1 PPARG PPARA RXRB PPARD THRA RXRG NR2E1 NCOR2 NR2F1 RARB NR0B2 NRBP1 NR2F6 NR2C2 NR2C2AP MED1 THRB NR1D1 VDR NR1D2 NCOR1 NR1H2 RORA RORC RORB NR2C1 ESR1 HNF4G NR5A1 NR4A2 ESRRA AR RXRA RARG HNF4A ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) TBK1 IRF3 UBA52 IRF7 TICAM2 TICAM1 TANK TLR4 LY96 TRAF3 UBB CD14 IKBKE OPTN UBC PTPN11 RPS27A VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis ACACA SCD ACSL1 HACD1 TECR HSD17B3 SLC27A2 HSD17B12 HACD3 HACD2 HSD17B8 HACD4 HTD2 FASN MORC2 CBR4 ELOVL1 ELOVL5 OLAH ELOVL4 ELOVL2 ACSL6 ACSL5 ELOVL3 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY PPT1 ELOVL6 ACSBG1 PPT2 SLC27A3 ACSBG2 SCD5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 RAD51B RAD51D ATM RAD51C DNA2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 KAT5 WRN EXO1 BRIP1 NBN RBBP8 BARD1 XRCC2 RMI2 PALB2 RAD50 RAD51 RMI1 TOP3A ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI PLA2G2A PLA2G4F PLA2G4E PLA2G10 PLA2G4C PLAAT3 PLA2R1 PLA2G1B PLA2G5 PLBD1 PLA2G4A MBOAT7 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 UBE2D1 PSMD12 ELOB PSMD11 PSMD14 ELOC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CITED2 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 VHL UBE2D2 HIF3A LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP VEGFA EPO CA9 HIGD1A EP300 ARNT CUL2 EPAS1 HIF1A CREBBP UBE2D3 PSMD8 PSMD6 AJUBA PSMD7 PSMD2 PSMD3 PSMD1 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling CHUK FBXW11 PSMA5 PSMA6 PSMA3 UBE2M PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 NFKB2 PSMA7 PSMB6 PSMB7 PSMB4 MAP3K14 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RELB SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 UBA3 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited CASP8 TNFRSF10B TNFRSF10A TNFSF10 FAS FASLG TRAF2 RIPK1 FADD TRADD RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP24 ARHGAP23 ARHGAP31 ARHGAP30 TFRC ARAP1 VAV1 SCFD1 ATP6AP1 TIAM1 HMOX2 RASGRF2 ARHGEF18 RTKN SOWAHC RHOA ARHGEF10L STK10 AKAP13 SLK LBR ARHGEF11 PGRMC2 ARHGEF10 ARHGEF12 ARHGEF17 STARD8 SNAP23 FLOT1 CIT DAAM1 ARHGAP6 ARHGEF3 FLOT2 ARHGEF1 ARHGEF2 ARHGAP42 PKN3 TRIO ARHGEF25 ARHGEF28 IQGAP3 ARHGAP1 STOM FMNL3 RHPN2 ARHGAP5 ARAP2 ARHGAP35 ECT2 PREX1 STARD13 ARAP3 OPHN1 JUP ARHGDIA CAVIN1 BCR STBD1 PCDH7 MCF2L MYO9A ARHGDIB NET1 ANLN TMPO DIAPH1 ABR PLEKHG3 ACTC1 RACGAP1 DLC1 PKN2 PKN1 DEPDC1B ARHGEF40 ARHGEF15 ARHGAP26 PLEKHG5 DOCK2 ARHGEF19 ARHGEF5 OBSCN ARHGEF4 VAMP3 ARHGEF7 NGEF PLD1 C1QBP KALRN ARHGAP39 ARHGAP21 LMAN1 STX5 YKT6 SRGAP1 MCF2 MCAM ERBIN KTN1 VANGL1 ARHGAP32 DIAPH3 VAPB ABCD3 TJP2 CAV1 ARHGAP9 ARHGAP8 ARHGAP4 GMIP VAV3 FARP1 DEF6 VMA22 VAV2 FAM13A TEX2 DDRGK1 ARHGAP11A ARHGAP11B ROCK1 TAGAP ROCK2 PLEKHG4 PLEKHG6 ARHGAP10 MYO9B TMEM87A PIK3R2 IQGAP1 PIK3R1 FAF2 EMC3 ARHGAP44 ARHGAP40 BCAP31 PREX2 ARHGAP45 ARHGAP19 ARHGAP18 AAAS SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants SOS1 EREG BTC SHC1 NRG2 HBEGF NRG3 EGFR NRG4 NRAS HSP90AA1 CDC37 HRAS ERBIN PLCG1 EGF ERBB2 NRG1 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels OPRK1 FKBP5 GPRIN1 MET PTPN4 HDAC1 SLC2A3 HDAC2 OPRM1 TRPC3 GRIN2B GRIN2A PTPN1 SIN3A GRIA2 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB TRIB3 PDPK1 AKT2 THEM4 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs PDGFRA SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol ISYNA1 INPP1 INPP5A IMPA1 IMPA2 INPP5B INPP4A INPP4B INPP5J OCRL MTMR9 SYNJ1 MTMR7 MIOX REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP SERPINA1 LAMB2 FN1 F5 LAMB1 LAMC1 MEN1 IGFBP1 IL6 GPC3 IGFBP3 VCAN PDIA6 VGF APOE WFS1 FSTL1 CP CHRDL1 TF ADAM10 MBTPS1 PENK SPP1 CDH2 BMP4 FGF23 C3 APOB C4A APOA1 PNPLA2 DNAJC3 CKAP4 PCSK9 APP CSF1 APOA2 TGOLN2 APOA5 KLK3 KTN1 KLK2 CALU SERPINC1 MFGE8 MMP1 CST3 GAS6 ALB QSOX1 PRKCSH AHSG P4HB F2 PROC TNC SPP2 TIMP1 DMP1 LGALS1 EVA1A CCN1 APLP2 FBN1 CTSG CHGB IGFBP5 IGFBP4 SCG3 IGFBP2 MGAT4A SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 SDC2 STC2 IGFBP6 KNG1 AMELX AMBN LTBP1 TMEM132A FUCA2 IGF2 IGF1 BPIFB2 PLG HRC MELTF HSP90B1 SERPINA10 MIA3 MSLN PRSS23 BMP15 MEPE RCN1 ENAM GZMH AMTN FAM20C VWA1 FAM20A MATN3 PAPPA2 ITIH2 AFP FSTL3 APOL1 FGA SERPIND1 GOLM1 KLK13 FGG NUCB1 NOTUM IGFBP7 ANO8 MMP2 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex PPIE COPS3 COPS6 COPS8 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 COPS5 MNAT1 AQR ERCC8 PRPF19 ISY1 GPS1 COPS4 COPS2 ZNF830 UVSSA XPA COPS7B COPS7A ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication H2AC6 H2AC7 H2AX KPNA1 H3-3B KPNB1 H2AC19 ORC5 H2AC14 H3C8 ORC4 H2BC12L ORC6 ORC1 H2AJ ORC3 KPNA6 ORC2 H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 H2AB1 H2AZ2 H2AC20 H2AC8 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB PPP2R1B PPP2R1A RB1 E2F1 PRIM2 PRIM1 POLA1 POLA2 PPP2R3B TFDP1 TFDP2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT DKK1 TNKS2 DKK2 DKK4 RNF146 PYGO1 H2AX PYGO2 SFRP1 SFRP2 ASH2L AMER1 CSNK1G2 CUL3 BCL9L BCL9 CCDC88C MEN1 CHD8 USP34 CBY1 RSPO2 SOST RSPO1 RSPO4 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 CXXC4 LRP6 ZNRF3 WIF1 H2AJ SRY RYK LGR6 LGR5 LGR4 PIP5K1B CTNNB1 H3C15 H2BC9 H3-4 H2BC8 APC H2BC5 H2BC3 SMARCA4 H2BC1 H2AB1 TLE1 H2AC8 H2AC6 H2AC7 PPP2R1B PPP2R1A TCF7 CSNK1E CSNK1A1 TERT GSK3B DPY30 XPO1 H2BC26 H2BC21 CTBP1 WDR5 EP300 PPP2R5E H2BC17 H2BC12 H2BC13 H2BC14 PPP2R5B H2BC15 PPP2R5A CREBBP PPP2R5D PPP2R5C H2BC11 RUVBL1 LEF1 PSMD8 RBBP5 PSMD6 PSMD7 PSMD2 PSMD3 XIAP TCF7L2 PSMD1 H2AZ2 TCF7L1 BTRC PPP2CA AXIN2 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 CDC73 RUNX3 PSMD13 PSMA7 PSMB6 PSMB7 SOX9 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC LEO1 PSMB1 RPS27A ADRM1 SEM1 RBX1 YWHAZ PSMC5 PSMC6 PSMC3 KMT2B PSMC4 PSMC1 PSMC2 HDAC1 TLE4 TLE2 KLHL12 WNT5A HECW1 CAV1 WNT9A SMURF2 RSPO3 KAT5 WNT8A WNT8B AXIN1 H2AC19 H2AC14 H2BC12L AKT2 SOX2 MYC AKT1 WNT1 SOX17 CSNK2A1 WNT3 CSNK2A2 WNT4 USP8 FZD1 CSNK2B DVL1 FZD2 DVL2 FZD5 DVL3 FZD4 WNT3A TLE3 FZD6 FZD8 H4C9 TRRAP SOX3 FRAT1 FRAT2 SOX6 SOX7 SOX4 H2AC20 RNF43 CTNNBIP1 SOX13 TNKS SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells PLCG2 SOS1 KRAS UBA52 INPPL1 IL34 CSF1 INPP5D UBB PIK3CD SRC PIK3CB UBC RPS27A CBL GAB3 HCK GAB2 CSF1R PIK3R1 PIK3CA SHC1 STAT1 LYN STAT3 YES1 THOC5 FYN GRAP2 PTPN11 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling SIPA1 YWHAZ RAP1GAP PRKACA PRKACG RAP1B PRKACB YWHAB RASGRP2 RAP1A RAF1 RAPGEF3 RAPGEF4 RASGRP1 RAP1GAP2 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DPH3 EEF2 DPH5 DPH6 DPH7 DNAJC24 DPH1 DPH2 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching SLIT1 ROBO1 ROBO2 NCK2 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway PRKCB ELMO2 DOCK1 BAIAP2 CALM1 ABI2 RASA1 ABI1 PRKACG PRKACB RAC1 VAV1 CTNND1 SHB CTNNB1 SH2D2A KDR PAK1 NOS3 ELMO1 RICTOR PAK3 SHC2 PAK2 NRAS AXL HRAS PTK2B CYFIP2 PLCG1 CAV1 CDH5 MAPK14 AHCYL1 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 PRKACA VAV3 CRK ITGAV PTK2 THEM4 PRKCD PRKCA VAV2 HSPB1 ITPR1 PXN ITPR2 PRR5 AKT2 ITPR3 PRKCZ AKT3 RHOA PIK3CB AKT1 ROCK1 ROCK2 MLST8 SPHK1 BCAR1 NCKAP1 NCF1 NCF2 TRIB3 NCF4 PDPK1 ITGB3 BRK1 CYFIP1 MAPKAP1 PIK3R2 PIK3CA PIK3R1 NCK2 CTNNA1 NCK1 CYBB HSP90AA1 JUP CYBA CDC42 WASF3 FYN NCKAP1L WASF1 MTOR WASF2 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex BCL7A BCL7C BICRAL BICRA BCL7B BRD9 SS18 SS18L1 SMARCD1 SMARCD2 SMARCA2 ACTB SMARCA4 SMARCC1 SMARCD3 SMARCC2 ACTL6A MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK BACH1 NFE2L2 HM13 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism ALDOB ALDH1A1 TKFC GLYCTK KHK MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation HLA-DRB3 HLA-DRB1 CTSC AP1G1 ACTR1A AP1S2 AP1B1 AP1S1 AP1S3 HLA-DPA1 AP1M2 AP1M1 SPTBN2 CTSA HLA-DQB2 KIF4B HLA-DQB1 KIF4A SEC31A SH3GL2 HLA-DOA HLA-DOB LAG3 KIF20A KLC1 DNM1 KLC4 DNM3 KLC3 DCTN1 KLC2 OSBPL1A KIF11 KIF15 CTSO ARF1 ACTR1B CTSH CTSF HLA-DPB1 CTSE KIF23 KIF22 HLA-DMA CTSV SEC23A HLA-DMB RILP CTSL CD74 SAR1B CTSK KIF26A DNM2 DCTN2 DCTN3 SEC24B DYNC1LI1 SEC24A DYNC1LI2 SEC24D HLA-DRA SEC24C IFI30 KIF18A SEC13 CLTC CLTA DYNLL1 DYNLL2 KIF2A KIF2C CANX KIF2B RACGAP1 DYNC1I2 AP2A1 RAB7A AP2A2 DYNC1I1 DYNC1H1 AP2M1 CENPE DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 AP2S1 AP2B1 CAPZB CAPZA1 CAPZA2 KIF5C KIF5B KIF5A KIFAP3 CTSS LGMN CTSB KIF3B KIF3A KIF3C HLA-DQA2 HLA-DRB5 CTSD HLA-DRB4 REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes LEF1 TCF7 TCF7L2 HDAC1 TLE1 TLE3 TCF7L1 TLE4 TLE2 CTBP2 TLE5 CTBP1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism FADS1 SCP2 ACSL1 ELOVL1 ELOVL5 ACOT8 ELOVL2 HSD17B4 ACAA1 ELOVL3 ABCD1 FADS2 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 KPNA1 NUP214 NDC1 NUP210 NUP155 HMGA1 AP1G1 NUP153 RAC1 PACS1 AP1S2 NUP93 AP1B1 NUP50 AP1S1 NUP35 AP1S3 NUP54 HLA-A SLC25A5 B2M SLC25A4 AP1M2 SLC25A6 AP1M1 PAK2 ATP6V1H ARF1 NUP107 NPM1 NUP160 KPNB1 NUP85 XPO1 SEC13 NUP133 LCK RANGAP1 PSMD8 PSMD6 FYN PSMD7 PSMD2 PSMD3 PSMD1 PPIA BTRC SKP1 CD4 RCC1 DOCK2 NUP43 PSMA5 AP2A1 PSMA6 PSMA3 RANBP1 AP2A2 PSMA4 PSMA1 CCNT1 PSMA2 RANBP2 UBA52 PSMD12 RAN PSMD11 ELOB AP2M1 PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NUP37 ADRM1 SEM1 RBX1 HCK PSMC5 CD8B PSMC6 ELMO1 PSMC3 CDK9 AP2S1 PSMC4 PSMC1 PSMC2 AP2B1 CUL5 NUP205 POM121 NUP188 PSIP1 AAAS CD28 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins ALOX5 ALOX15 HPGD LTA4H RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants SPRED3 SPRED2 SPRED1 HRAS NF1 NRAS EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF4EBP1 EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 EIF5 RPS13 EIF5B RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 EIF2B5 RPL15 EIF2B4 RPS2 EIF2B3 RPL18 EIF2S3 RPL17 EIF2B2 EIF2B1 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 HSPA1A NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 XPO1 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors GRIP2 GRIA1 PRKCB AP2A1 EPB41L1 TSPAN7 GRIA3 GRIA4 PRKCA MDM2 CAMK2B CAMK2D CAMK2A DLG1 DLG4 GRIA2 AKAP5 CAMK2G PICK1 CACNG8 MYO6 CACNG2 CACNG3 CACNG4 GRIP1 NSF PRKCG DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor VWF F8 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease RPIA TALDO1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state MCM6 MCM2 PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 ORC5 PSMB7 ANAPC5 ORC4 PSMB4 ANAPC1 ORC6 PSMB5 ANAPC2 ORC1 UBB MCM8 GMNN PSMB2 CCNA2 PSMB3 ORC3 CCNA1 ORC2 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 SKP2 CCNE2 CCNE1 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 MCM7 PSMD3 PSMD1 MCM3 MCM4 SKP1 MCM5 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM2 SEL1L AMFR RNF103 UBA52 TRIM13 MAN1B1 RNF185 UBB UBC RPS27A DERL2 CALR OS9 SYVN1 PDIA3 RNF5 PRKCSH EDEM1 CANX GANAB DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA EGF AREG MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2I POLR2J PRKRA POLR2K DICER1 POLR2L TARBP2 BCDIN3D RAN XPO5 DROSHA POLR2A POLR2B AGO3 POLR2C DGCR8 AGO4 POLR2D POLR2E AGO1 POLR2F AGO2 POLR2G POLR2H NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 NTRK2 RAC1 DOCK3 BDNF ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry TMPRSS2 ACE2 VCP CTSL DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema F12 SERPING1 KLKB1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription EZH2 H2AX PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 H3-3B TEAD4 H3C8 FOS H2AJ YAP1 H3C15 RICTOR SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 PRR5 INTS12 GSK3B INTS13 INTS14 DPY30 INTS10 ICE1 ICE2 H2BC26 SSU72 H2BC21 NABP2 MLST8 NABP1 WDR5 YWHAG ELL2 EED ELL3 PDPK1 ZC3H8 H2BC17 RPRD2 RPAP2 H2BC12 RPRD1B H2BC13 RPRD1A H2BC14 POU2F2 H2BC15 H2BC11 PRKAA1 PRKAA2 LEF1 RBBP4 RBBP5 RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C TNRC6A TNRC6B CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TP53 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 PAPOLA SYMPK CPSF4 TGFB1 PARP1 PABPN1 CDC73 BLK ELF1 ELF2 CBFB PAX5 SKIC8 RUNX1 CTR9 RTF1 LEO1 PAF1 SOX2 ZNF521 TRPC3 PRKCQ SOX9 YWHAH YWHAZ KIT HDAC1 POMC CAV1 CGA CPSF7 FURIN RPTOR STK11 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYA NFYB NFYC GPAM SP1 CASP1 TP63 TNFRSF10B TNFRSF10A ITCH FAS CYCS BAX STUB1 PRKACA CAMK2B CAMK2D CAMK2A CAMK2G EHMT2 EHMT1 MAPKAPK5 TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM2 MDM4 BMI1 VENTX RING1 CCNA2 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PHAX SNRPD3 PRMT5 SNRPG SNRPE SNRPF SNRPB PHF20 CHEK2 ZNF385A PCBP4 SRRT GRIN2A CAMK4 PLK2 MDC1 SPI1 MT-CO1 RBPJ NOC2L ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 SCO2 ZNF705EP DDIT3 DDIT4 TXNIP MT-CO2 MT-CO3 MYL9 ZNF28 ZNF274 ZNF273 MEAF6 ZNF20 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 ZNF26 SFN ZNF268 PPARGC1B ZNF267 PRELID3A ZNF266 ZNF264 ZNF263 ABCA6 NR2F1 ZNF34 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 BBC3 MED12 MED14 MED13 HEY1 CASP10 MED10 ZNF41 HEY2 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 CNOT6L ACTL6B ZNF480 ACTL6A MED27 MED26 SIRT3 DDB2 MED23 MED25 MED24 MMP13 MED20 ZNF479 ZNF235 ZNF234 ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT EGFR BGLAP PLAGL1 SPP1 ZNF227 ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 USP9X ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 UBE2D3 PSMD8 RORC RORB PSMD6 YY1 PSMD7 SESN3 PSMD2 ZNF208 PSMD3 SESN2 PSMD1 ZNF205 ZNF689 KMT5A ZNF688 ZNF446 SKP1 ZNF445 PITX2 PRKCB ZNF202 PSMA5 ZNF443 PSMA6 ZNF200 PSMA3 ZNF684 PSMA4 ZNF442 PSMA1 ZNF441 PSMA2 BNIP3L ZNF682 UBA52 ZNF440 ZNF681 PSMD12 ZNF680 PSMD11 AFF4 ZFP69B MLLT1 PSMD14 FOXP3 MLLT3 PSMD13 NPAS4 SUPT6H CUL1 MAF IWS1 PSMA7 ZNF439 EAF1 ZNF679 EAF2 RELA ZNF678 PSMB6 ZNF436 PSMB7 ZNF677 PSMB4 ZNF676 PSMB5 ZNF433 ZNF675 UBB PSMB2 ZNF432 PSMB3 PVALB ZNF431 UBC PSMB1 ZNF430 RPS27A GRIA2 KMT2D ADRM1 ZNF671 NFKB1 ZNF670 SEM1 CPAP PSMC5 MAX PSMC6 DLX5 PSMC3 DLX6 PSMC4 KMT2B PSMC1 FOXO6 PSMC2 FOXO4 FOXO1 ZNF840P ATXN3 SOCS3 MED30 MOBP ZKSCAN7 HDAC4 ZNF429 MED31 THRB ZKSCAN8 UBE2I ZKSCAN3 VDR SMYD2 NR1H2 RORA ZNF669 ZNF668 NR3C1 ZNF426 NR2C1 ZNF667 ESR1 ZKSCAN5 ZNF425 ZKSCAN4 NR5A1 ZNF665 NR4A2 AR ZNF664 ZKSCAN1 RXRA SOCS4 SUMO1 BCL2L14 ZNF662 ZNF420 RARA ZNF660 PGR PPARG BRPF1 PPARA BRPF3 TNFRSF10C FBXO32 MRE11 G6PC1 BRCA1 TNFRSF10D RGCC ZNF419 KAT5 ZNF418 EXO1 ZNF417 ZNF658 ZNF416 CHEK1 ZNF415 NBN PIN1 TOPBP1 ZNF655 SP7 PPP1R13B COX4I1 COX4I2 RFC5 PTEN RFC3 RMI2 ITGAL PPP1R13L RFC4 ZNF649 DGCR8 YAF2 RFC2 RMI1 NKX3-2 ZNF641 TOP3A TRIM63 HUS1 APAF1 ITGA4 TNFRSF18 RAD51D ARNT RABGGTB DNA2 RABGGTA RHNO1 BLM RRM2B HAND2 ZNF875 PCNA ITGA5 SRF PPM1D WRN ZNF627 ZNF626 BRIP1 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 RBBP8 ATRIP E2F5 ZNF620 BARD1 E2F6 E2F7 E2F8 RPA1 ZNF860 RPA2 PTPN1 MGA TBX5 RAD50 PINK1 RAD51 ZNF619 RPA3 SST IL2RA ZNF616 RAD17 SYT10 RAD1 ZNF615 ATM ZNF614 RAD9B ZNF613 ATR ZNF611 RAD9A PTPN4 ANAPC15 ZNF610 ANAPC16 ANAPC7 TRIM33 SMARCB1 UBE2C CCNC UBE2E1 UXT UBE2D1 LGALS3 ZNF729 ANAPC10 TRIM28 ANAPC11 ZNF727 CCNB1 CDC23 ZNF726 ZNF724 UBE2S CDC26 EPC1 CDC27 CCN2 ZNF721 CDC16 SMARCC1 CDK1 ANAPC4 SMARCC2 ANAPC5 ZFP1 ANAPC1 ZFP2 ANAPC2 ZNF718 ZNF717 ZNF716 SRC ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 ZNF324B CTNNB1 L3MBTL2 FOXG1 MET TGFA ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 YWHAB APOE PCK1 CRADD IQSEC3 MAPK1 SMARCA2 SMARCA4 SNW1 MAPK3 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C MAPK14 CTSL CTSK HNF4A COX8A MAPK11 SREBF1 COX8C PBRM1 SATB2 COX5B COX5A RXRB ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 COX6C GCK ATF2 VEGFA TTC5 CCNG2 CCNG1 HDAC3 MAMLD1 ZFP28 SMARCD3 PRDM7 PRDM1 COX6A1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 XPO1 COX6B2 GEM COX6B1 ZNF92 EP300 GPRIN1 NDRG1 TBL1X HIGD1C IRAK1 TFAP2A PPARGC1A TFAP2B ZFHX3 TFAP2C MED1 TFAP2D CREBBP AUTS2 MEF2C TFAP2E CNOT10 IL2 IL3 BMP2 NR1D1 SIRT1 CNOT11 TCF3 NCOR1 DYRK2 TBL1XR1 LDB1 CARM1 CHD4 CHD3 TRIAP1 BMAL1 PIDD1 YWHAQ MYBL2 TGIF1 ZNF75CP RBM14 TGIF2 CAT TMEM219 RETN NFATC2 AURKA INS CALM1 MTA2 RRM2 YWHAE ZNF804B REST JUN KRAS FASLG ZNF175 SOD2 MAML2 CDC25C MAML1 FOXO3 SERPINE1 GLS NAMPT ZSCAN32 MYB PIP4K2A PRDX2 BCL2L11 PIP4K2B JUNB CDK5 ZNF169 RNF111 GAMT PRDX1 ZNF705G ZNF705D ZNF160 CDK5R1 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 NOTCH1 RBX1 ZNF155 ZNF154 ZNF394 NEDD4L NKX2-5 NR2C2AP NFE2 IHH PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 SETD1B SETD1A CDC7 NR1D2 ZNF37A ZNF702P ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET GPI BTG2 RARG BTG1 SETD9 CRH CHM GLI3 GLI2 ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 RSPO3 ZNF124 ZIK1 BRD2 BRD1 TCF12 NCOR2 KAT2B KAT2A SNAPC5 TAL1 SNAPC1 RARB SNAPC2 ZNF599 SNAPC3 ZNF114 SNAPC4 ZNF143 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 GPS2 ZNF589 ZNF347 BRD7 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 WWOX ZNF582 PCGF6 TIGAR PCGF5 PCGF2 WWP1 HIPK1 POU2F1 POU4F1 POU4F2 ZNF33B HIPK2 ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 ITGA2B YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 MEN1 ZNF563 IGFBP1 ZNF562 GAD1 ZNF320 GAD2 ZNF561 USP7 ZNF560 IGFBP3 USP2 NRBP1 KAT6A ZNF559 ZNF317 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 NOTCH2 ZNF793 ZNF551 CSF1R RB1 ZNF792 CDKN1A NOTCH3 CDKN1B ZNF550 CCND3 ZNF791 ZNF790 FZR1 CCND2 NOTCH4 CCND1 ZNF767P E2F1 ZNF549 ZNF548 ABL1 ZNF547 SKP2 DAXX ZNF546 ZNF304 ZNF544 CDK6 ZNF786 TFDP1 CCNE2 ZNF302 ZNF785 TFDP2 LSM10 ZNF543 CDK4 SLBP CCNE1 SKIL LSM11 ZNF300 CDK2 PLXNA4 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC PPP2R1B CNOT4 PPP2R1A CDK8 ZFP69 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 ZNF774 CNOT9 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 SIN3A ZNF528 ZNF764 LBR ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 HDAC2 SMARCD2 PPP2R5C RNF34 GLS2 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 BIRC5 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 AURKB KCNIP3 KLF4 PML ZNF738 PPP2CA ZNF737 PPP2CB ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 TP53AIP1 ZNF607 ZNF606 ZNF605 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 CITED1 CITED2 CITED4 PRMT6 KRABD5 KRABD4 PRMT1 MSH2 KRABD3 GP1BA PMS2 SGK1 ZNF2 MLH1 ZNF3 NPY ARNT2 ZNF354A ZNF354C ZNF354B STEAP3 LMO1 LMO2 TJP1 KCTD1 OCLN ATP1B4 LIFR KCTD6 FANCD2 COXFA4 NOP2 COX7A2 CCNH COX7A1 RNMT PMAIP1 POLR2A SMAD2 POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E CBX5 POLR2F SMURF2 POLR2G CBX3 POLR2H SMURF1 POLR2I SMAD6 POLR2J ESR2 POLR2K SMAD7 POLR2L NR4A1 RNGTT TP53I3 GTF2H1 NR4A3 GTF2H2 JMY SUPT5H KDM5B GTF2H3 THRA GTF2F1 CGB8 GTF2F2 SLC2A3 GTF2H4 NR2E1 GTF2H5 YBX1 CDK7 CASP6 ERCC3 CASP2 ERCC2 AXIN1 MNAT1 OPRM1 ARID1A ARID1B RBL2 H2AC19 RBL1 H2AC14 IFNG H2BC12L ZNF197 AKT2 ZNF195 MYC NR2C2 AKT3 THBS1 HSPD1 AKT1 ERBB2 HES1 PRKAB2 ZNF189 CSNK2A1 ZNF286A CSNK2A2 ZNF184 PRKAB1 ZNF180 CSNK2B OPRK1 ARID3A DEK MAPKAP1 WWTR1 YES1 H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly HSPA9 UQCRB UQCC3 UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH LYRM4 UQCRQ LYRM7 UQCRC1 LETM1 UQCRFS1 UQCRC2 CYC1 MT-CYB FXN VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation PRKCB PDPK1 KDR CALM1 RASA1 PRKCD PRKCA NRAS HRAS ITPR1 ITPR2 PLCG1 ITPR3 PRKCZ AHCYL1 SPHK1 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR CXCL8 VAV1 PAK1 MAPK7 TIAM1 DGKG DGKE C5AR2 DAGLA C5AR1 DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI DGKH RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 GRK3 ARHGEF10L PIK3CG AKAP13 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 RHOB PDPK1 C3 C5 ARHGEF3 ARHGEF1 ARHGEF2 PIK3CA ARHGEF25 ECT2 CDC42 NET1 ABR ADRA1D ADRA1B ADRA1A GPR176 ARHGEF40 GPR15 PLEKHG2 GPR27 ARHGEF15 GPR25 PLEKHG5 GPR20 ARHGEF19 GPR32 RHOC GPR45 TIAM2 GPR150 OBSCN GPR83 ARHGEF4 GPR84 ARHGEF7 PRKACG NGEF PDE2A PPP1R1B ARHGEF6 FGD1 PDE3A PRKACB FGD2 CCL4L2 RGS8 GNA13 FGD3 PDE8B FGD4 PDE8A TBXA2R PCP2 GRK6 GNA12 ARHGEF33 GPSM1 ARHGEF35 GPSM2 ARHGEF37 PDE4A ARHGEF39 GPSM3 ARHGEF38 PDE4D PLXNB1 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 PDE7B PDE7A OPN1MW CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P GNAT3 HRH1 HTR6 C3AR1 HTR7 RGS9 RGS6 HRH3 ADCY9 RGS7 HRH2 PRKAR1B HRH4 DRD1 BTK DRD2 PRKAR2B DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D GNAI3 ADCY4 HTR1A TAAR5 ADCY3 HTR1B TAAR2 PRKX ADCY2 HTR5A TAAR1 ADCY1 ADCY8 GPR143 GNAQ ADCY7 ADRB3 ADCY6 GNAI1 ADCY5 GNAI2 CAMK4 CYSLTR1 CYSLTR2 GNAZ GNA14 GNA15 GNA11 ADORA2B RGS11 S1PR1 PLCB4 PRKCG KPNA2 GNAL NBEA EGFR RASGRF2 ARHGEF9 CAMKK1 CAMKK2 GABBR2 GABBR1 PRKCB RHO GNAT1 SAA1 GNAT2 PRKCA PLCB3 PLCB1 PLCB2 PRKAR1A PPP3CC MCHR1 ITGA5 TRPC7 TRPC6 TRPC3 SST CCL2 SRC NRAS SSTR3 MAPK1 HRAS MAPK3 PRKCQ SOS1 RASGRP2 ARHGEF18 RHOA OPN1SW ITGB1 TRIO ITSN1 PREX1 MCF2L ARHGEF16 PPP3CA PPP3CB RASGRP1 PPP3R1 CALM1 CCR5 ARHGEF5 APP ARHGEF26 KALRN MC4R EDNRB CDK5 MCF2 RPS6KA1 EDN1 EDN3 GLP1R UCN VIPR1 MC3R VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP PPP1CA ADGRE2 POMC SHH GNGT2 MC1R ADGRE5 UCN3 UCN2 MC5R ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP MGLL ADCYAP1 SMO CRH IAPP ADCYAP1R1 CGA RAMP2 CALCA TSHB RAMP3 VAV3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 CX3CR1 VAV2 PTHLH CRHR1 GHRHR WNT6 GNG10 PRKAR2A GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 ROCK1 CXCR4 WNT2 ROCK2 CD55 WNT3 WNT4 FZD1 WNT10B FZD3 WNT10A FZD2 FZD5 FZD4 CXCL12 WNT3A PTCH1 FZD7 GCGR WNT7B FZD6 PTCH2 FZD9 SCTR FZD8 WNT7A SOS2 GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH MRGPRD GNB1 CMKLR1 PF4 GNAS PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 VIP GALR3 RAMP1 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 CCL19 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 HBEGF ECE1 ECE2 ANXA1 PRLHR ADORA2A CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN TAS2R20 RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 KEL PPP2R1B TAS2R40 PPP2R1A TAS2R41 TAS2R42 TAS2R43 LHB TAS2R45 TAS2R46 NLN MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP ADRA2C TAS2R38 ADRA2B TAS2R39 ADRA2A TAS2R60 PTGDR2 CX3CL1 CCR9 PDE3B CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 PPP2R5D NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 PPP2CA TAS2R9 PPP2CB CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 RGSL1 GRM3 GRPR GRM2 EDNRA GRM4 PROK2 GRM7 PROK1 GRM6 UTS2R GPER1 NPFF GRM8 TRHR TAS2R1 UTS2B TAS2R3 AGTR1 TAS2R5 PTGFR TAS2R4 LPAR1 PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR TAS1R2 LPAR5 S1PR3 LPAR6 TAS1R1 NMS S1PR2 NMU S1PR5 GNRH2 TAS1R3 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY ACKR4 AVPR2 BRS3 ACKR3 GPRC6A OXT ACKR2 GPR132 AVP ACKR1 CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR AHCYL1 NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 PRKACA F2RL2 F2RL3 GPR68 PDE1C GPR65 PDE1B PDE1A PMCH RGS4 GRK2 PRKCD RGS5 RGS2 PLA2G4A RGS3 RGS1 GHSR OPRM1 CAMK2B CASR CAMK2D F2R CAMK2A LTB4R2 UTS2 ITPR1 NTS ITPR2 KNG1 AKT2 MCHR2 ITPR3 GRK5 AKT3 TAC3 TAC1 AKT1 CRHR2 OPN4 NMUR2 NMUR1 CAMK2G MLNR TRH LTB4R GRM1 OPRK1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 ARRB1 XCL2 PIK3R3 XCL1 PIK3R2 ARRB2 PIK3R1 RGS18 RGS17 PIK3R6 RGS19 PIK3R5 RGS13 RGS16 P2RY6 P2RY2 RPS6KA3 P2RY1 RPS6KA2 RGS21 CCK HCRTR2 HCRTR1 KISS1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD POMC MC2R ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) ACACA PMVK SC5D FDFT1 PPARA FDPS NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SMARCD3 CHD9 HELZ2 TGS1 TBL1X FASN NCOA1 MED1 NCOA2 CREBBP NCOA6 TM7SF2 GGPS1 HMGCS1 TBL1XR1 ELOVL6 CARM1 LSS SREBF2 MTF1 MVD IDI1 MVK RXRA ACACB NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects PNP NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 CHUK IFIH1 CASP8 RNF135 TRIM25 MAVS TRIM4 RIGI CASP10 IKBKB RIPK1 IKBKG FADD MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis H2AX ASH2L CCNC PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2C GPAM SCD ADIPOQ HDAC3 PHLDA1 ACSL1 PEX11A DPY30 H2BC26 H2BC21 CIDEC WDR5 EP300 TBL1X H2BC17 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 CREBBP NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 PDK4 ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL LIPE DGAT2 MED30 MED31 KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism PAPSS2 PAPSS1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 NNMT RPL23 RPS5 AHCY RPL22 RPS6 RPSA MAT1A RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 CBS RPL36A RPS27L RPS15A TXNRD1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A CTH RPL23A UBA52 RPL22L1 FAU RPL26L1 QARS1 RARS1 HNMT MARS1 RPS27A SEPHS2 SECISBP2 EEFSEC SEPSECS DARS1 PSTK LARS1 INMT SARS1 GNMT EEF1E1 SCLY KARS1 IARS1 AIMP1 AIMP2 EPRS1 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX5 ALOX15 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway DERA TKT RPIA PGD SHPK RBKS TALDO1 PRPS2 PRPS1 RPEL1 RPE PGM2 PGLS PRPS1L1 G6PD CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 SEL1L PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 RNF185 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 RNF5 ERLEC1 PSMD8 CFTR PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts SLCO1B1 NCOA1 SLCO1B3 BAAT NCOA2 STARD5 SLC10A1 SLC10A2 SLC51A SLC51B SLC27A5 NR1H4 ABCC3 ALB FABP6 ABCB11 SLCO1A2 RXRA SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability CALM1 VAV3 THEM4 RAC1 VAV2 PRR5 AKT2 VAV1 AKT3 AKT1 CTNND1 MLST8 CTNNB1 TRIB3 PAK1 PDPK1 NOS3 MAPKAP1 RICTOR PAK3 PAK2 CTNNA1 HSP90AA1 JUP CAV1 CDH5 MTOR DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling CHUK FBXW11 PSMA5 PSMA6 PSMA3 UBE2M PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 NFKB2 PSMA7 RELA PSMB6 PSMB7 PSMB4 MAP3K14 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RELB SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 UBA3 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle ARHGAP12 ARHGAP22 ARHGAP20 ARHGAP29 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 RAC1 ARHGAP31 ARHGAP30 DOCK6 DOCK9 TFRC ARAP1 ALS2 VAV1 FMNL1 LAMTOR1 PAK1 PAK3 PAK2 DOCK3 FARP2 PLD2 TIAM1 JAG1 SOS1 RASGRF2 ARHGEF18 PARD6A LBR ARHGEF11 ARHGEF10 NCKAP1 NCF1 NCF2 NCF4 DOCK8 SNAP23 CIT ITGB1 BRK1 CYFIP1 DOCK10 DOCK5 ARHGAP42 DOCK4 TRIO BAIAP2L1 ARHGEF25 PIK3CA CDC42BPA IQGAP3 ARHGAP1 GIT1 SWAP70 ARHGAP5 ARAP2 ARHGAP35 CYBB ECT2 PREX1 ARAP3 OPHN1 ARHGDIA CYBA BCR CDC42 MCF2L AMIGO2 ARHGDIB NOXO1 ARHGAP17 EMD TMPO ARHGAP15 ABR PLEKHG3 RACGAP1 DLC1 PKN2 VRK2 NHS PKN1 LEMD3 NCKAP1L DEPDC1B WASF1 WASF2 NISCH PLEKHG2 CDC42EP1 ARHGEF15 GIT2 ARHGAP26 DOCK2 ARHGEF19 DOCK1 BAIAP2 ARHGEF5 TAOK3 TIAM2 RAB7A ABI2 EPHA2 NOXA1 ARHGEF4 VAMP3 ABI1 NOX3 ARHGEF7 NGEF GARRE1 NOX1 FERMT2 ARHGEF6 PLD1 IQGAP2 KALRN GNA13 ARHGAP39 ARHGAP21 SRGAP3 SRGAP2 YKT6 SRGAP1 PAK4 MCF2 MCAM ARHGEF39 ERBIN SLC1A5 MPP7 DOCK7 KTN1 VANGL1 ARHGAP32 DIAPH3 ESYT1 CYFIP2 WIPF1 WIPF2 CAV1 WIPF3 ARHGAP9 ARHGAP4 GMIP CDC42EP4 VAV3 FGD5 WASL CHN2 CHN1 FARP1 DEF6 WAS VAV2 FAM13B FAM13A TAGAP PLEKHG4 PAK6 PLEKHG1 PAK5 PLEKHG6 ARHGAP10 MYO9B SH3BP1 ABL2 SPATA13 PIK3R3 PIK3R2 IQGAP1 PIK3R1 SOS2 SYDE2 WASF3 ARHGAP44 DOCK11 RALBP1 PREX2 ARHGAP45 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition CEP57 CETN2 PLK1 CEP164 ACTR1A CCNB1 PCM1 CNTRL CDK1 CEP290 NINL CCNA2 CCNA1 RAB8A OFD1 CDKN1A TUBB HAUS4 HAUS3 FZR1 HAUS6 HAUS5 TUBG1 FBXL18 HMMR HAUS2 HAUS1 CDK2 CEP63 NEK2 SFI1 SDCCAG8 PPP2R1B PPP2R1A DCTN2 SSNA1 SGO1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E PHLDA1 CCNB2 NEDD1 ALMS1 CEP41 CEP43 XPO1 YWHAG EP300 DYNLL1 HSP90AA1 CKAP5 PSMD8 RBBP4 PSMD6 MAPRE1 PSMD7 PSMD2 PAFAH1B1 PSMD3 MYBL2 DYNC1I2 PSMD1 BTRC SKP1 PPP2CA PPP2CB FBXW11 AURKA PSMA5 PSMA6 PSMA3 CLASP1 YWHAE PSMA4 PSMA1 PSMA2 UBA52 PPP1R12A DYNC1H1 GTSE1 CDC25C PSMD12 FKBPL PSMD11 NDE1 CDC25A PSMD14 CDC25B PSMD13 CENPF CUL1 PSMA7 HJURP MIS18BP1 PSMB6 PSMB7 PSMB4 PSMB5 UBB TPX2 PSMB2 OPTN PSMB3 TUBGCP2 UBC PSMB1 RPS27A TUBGCP5 ADRM1 TUBGCP6 SEM1 TUBGCP3 CPAP TUBGCP4 RBX1 PSMC5 TUBG2 PSMC6 FBXL7 MZT2B PSMC3 MZT2A PSMC4 NME7 PSMC1 PPP1CB LIN54 MZT1 PSMC2 LIN52 PKMYT1 LIN37 LIN9 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B CCNH TICRR FOXM1 AKAP9 PRKAR2B PPP2R2A TUBA4A PRKACA TP53 CDK7 CCP110 MNAT1 CEP250 CDK5RAP2 CEP135 CEP131 CSNK1D TUBA1A HSP90AB1 CEP70 CEP72 CEP192 CEP76 CEP78 PPP2R3B PLK4 AJUBA ODF2 TUBB4B TUBB4A SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs SNRPD3 NCBP1 SNRPG NCBP2 LSM10 SNRPE ZNF473 LSM11 SNRPF SNRPB RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins PLK1 RAC1 FMNL1 FMNL2 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 RHOA NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 RHOB SPDL1 DAAM1 ITGB1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 FMNL3 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP CDC42 BIRC5 KIF2C KIF2B DIAPH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 RHOC BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI SRGAP2 TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS DIAPH3 NUP37 SPC25 MRTFA ACTB SCAI PFN1 PFN2 ACTG1 DVL1 DVL2 DVL3 SRF RHOD EVL APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B CDC20 ANAPC15 ANAPC16 ANAPC7 UBE2C UBA52 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 UBB ANAPC2 UBC RPS27A METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors COQ6 ACO1 COQ5 GCHFR COQ4 HPDL CALM1 COQ3 COQ2 COQ8B COQ8A PRKG2 AKT1 NOS3 HSP90AA1 DHFR IDH1 PTS SPR PDSS2 PDSS1 GCH1 STARD7 COQ9 COQ7 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis GSK3A DUSP16 RAB7A KPNA1 CTSG UBA52 SFPQ B2M RAB5A KPNB1 VPS33B PGK1 CORO1A RNF213 UBB UBC RPS27A HGS TLR2 MRC1 MAPK1 ATP6V1H MAPK3 LTF NOS2 ENO1 TRIM27 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation AKAP9 KCNH2 KCNE1 KCNE2 KCNE3 KCNE4 KCNA5 KCNE5 KCNQ1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion PAK1 PLXNA2 CFL1 PLXNA3 FES PAK3 PAK2 SEMA3A RAC1 HSP90AA1 LIMK1 PLXNA1 NRP1 FYN PLXNA4 HSP90AB1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation FGF9 FGF20 FGF23 GALNT3 FGF16 FGF18 FGF1 FGF2 FGF4 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors H2AX PLK1 RAC1 H3-3B H3C8 H2AJ CDH1 CTNNB1 H3C15 PAK1 PAK3 PAK2 KLC1 H2BC9 KLC4 H2BC8 KLC3 YWHAB H2BC5 KLC2 H2BC3 MAPK1 H2BC1 MAPK3 H2AB1 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 PRKCZ RTKN RHOA XPO1 H2BC26 H2BC21 NCKAP1 NCF1 YWHAG NCF2 RHOB NCF4 PDPK1 CIT H2BC17 DAAM1 ITGB1 BRK1 CYFIP1 H2BC12 H2BC13 H2BC14 PKN3 H2BC15 NCOA2 IQGAP3 RHPN2 H2BC11 CYBB CYBA CDC42 CFTR CTTN NOXO1 DIAPH1 YWHAQ RHOG PKN2 PKN1 H2AZ2 NCKAP1L WASF1 WASF2 BAIAP2 CALM1 RHOC ABI2 NOXA1 YWHAE ABI1 NOX3 NOX1 PPP1R12A PPP1R12B CDC25C PPP1R14A IQGAP2 YWHAH KLK3 KTN1 KLK2 KDM4C DIAPH3 YWHAZ PPP1CB RAC2 S100A9 S100A8 ACTB CYFIP2 WIPF1 SCAI WIPF2 WIPF3 BTK ARPC1B ARPC1A CFL1 WASL PTK2 WAS PFN1 ROPN1 GOPC PFN2 TAX1BP3 FLNA NF2 PRC1 ROCK1 ROCK2 MYH9 ACTG1 NCKIPSD DVL1 DVL2 DVL3 ARPC4 ARPC5 KDM1A ARPC2 CTNNA1 ARPC3 NCK1 KIF14 ACTR3 RHOD ACTR2 EVL WASF3 MYL9 RHPN1 SFN MEN1 FMNL1 FMNL2 MYLK MYL12B CDKN1B MYH11 ABL1 MYL6 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 LIN7B KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 DLG4 PIK3R4 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PIK3C3 PPP2R5A PPP2R5D PPP2R5C DYNLL1 FMNL3 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PRKCB PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI LIMK2 TAOK1 SRGAP2 LIMK1 CENPK CENPL MYH14 CENPM MYH10 CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 MRTFA AR PRKCD PRKCA KIF5B KIF5A PIN1 H2AC19 H2AC14 H2BC12L IQGAP1 SRF H4C9 H2AC20 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism FADS1 SCP2 ACSL1 ELOVL1 ELOVL5 ACOT8 ELOVL2 HSD17B4 ACAA1 ELOVL3 ABCD1 FADS2 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation TIMP2 TIMP1 TGFBR3 MMP14 PSENEN MMP16 PSEN2 PSEN1 APH1A NCSTN APH1B TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism PPP1CC ABHD5 FABP12 PRKACA PPP1CB LIPE PRKACG PRKACB FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 CAV1 PLIN3 PNPLA4 PNPLA5 PLIN1 MGLL CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 CYBA NCF4 CD36 ITGAV ITGB5 CYBB RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling DNM2 DNAL4 AP2A1 AP2S1 AP2A2 SH3GL2 CLTC DNM1 CLTA DNM3 AP2M1 AP2B1 NTRK1 NGF NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors UBE2I TFAP2A TFAP2B WWOX TFAP2C TFAP2D TFAP2E SUMO1 KCTD1 KCTD15 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors H2AX H3-3B H3C8 FOS H2AJ SRC H3C15 NOS3 TGFA H2BC9 H2BC8 APOE H2BC5 PCK1 NRAS H2BC3 MAPK1 HRAS H2BC1 MAPK3 FOSB EGF BCL2 AREG H2AB1 H2AC8 H2AC6 H2AC7 RXRB RXRG ATF2 HDAC3 DLD PRKCZ XPO1 H2BC26 H2BC21 NRIP1 EP300 TBL1X PDPK1 H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 PIK3CA CREBBP H2BC11 NCOR1 TBL1XR1 CARM1 H2AZ2 TNRC6C TNRC6A CALM1 TNRC6B JUN CCNT1 FOXO3 MYLIP MYB TBP GTF2A1 GTF2A2 ANGPTL3 ABCG1 CETP CDK9 HDAC1 ABCA1 APOC4 GNGT1 NR1H3 GNGT2 APOC2 APOC1 FABP5 FABP6 CAV1 GNAT3 DHRS4 PLIN1 RARG PTK2 GNAI3 NCOR2 KAT2B IGF1R ZDHHC7 GNG10 CRABP2 RARB GNG3 ZDHHC21 GNAI1 PPID GNG2 GNAI2 CAV2 MMP7 GNG5 GNG4 UGT1A3 GNG7 PPP5C GNG8 GPS2 HSP90AB1 SPHK1 KDM4A CXCL12 FOXA1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD GNG12 NCOA3 GNG11 NR5A2 KDM3A GNG13 TFF3 KDM1B APOD TFF1 KANK1 GNB2 ARL4C CXXC5 EEPD1 GNB1 KDM4B PTGES3 GNB4 USF2 GNB3 USF1 ZNF217 GNB5 EBAG9 MMP2 GATA3 MMP9 FKBP5 ELK1 EREG CDKN1B UHMK1 BTC EPGN HBEGF CCND1 KPNA2 SMC3 PPARD EGFR GPAM SCD SP1 RAD21 STAG1 STAG2 ALDH1A1 SMC1A HSP90AA1 YY1 PDHB PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 CBFB PDHA1 RUNX1 CITED1 ADH4 ADH1C S1PR3 PRMT1 ADH1A FASN KCTD6 NR1H2 ESR1 POLR2A POLR2B POLR2C POLR2D POLR2E RXRA POLR2F ABCG8 POLR2G ABCG5 POLR2H POLR2I RARA ESR2 POLR2J PGR POLR2K POLR2L GTF2F1 KAT5 CRABP1 GTF2F2 AKR1C3 DHRS3 ALDH1A3 CYP26A1 SDR16C5 AXIN1 CYP26B1 CYP26C1 DHRS9 RDH11 H2AC19 ALDH1A2 H2AC14 RDH10 H2BC12L RDH16 AKT2 RDH5 MYC RDH14 AKT3 RDH13 ALDH8A1 AKT1 STRN MMP3 PIK3R3 PIK3R2 SRF PIK3R1 H4C9 JUND MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation FGFR1 FGF1 FGF2 CEP43 FGF4 FGF6 FGF9 FGF20 STAT5A FGF23 STAT5B GAB2 ZMYM2 PIK3R1 PIK3CA STAT1 LRRFIP1 STAT3 BCR CUX1 FGFR1OP2 MYO18A CPSF6 ERLIN2 TRIM24 BAG4 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RTEL1 RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL9A2 COL6A5 PPIB COL1A1 COL1A2 P4HB P4HA1 P4HA2 P4HA3 ADAMTS2 ADAMTS3 COL17A1 COL18A1 COLGALT2 PLOD3 COL15A1 COL16A1 PLOD2 PLOD1 COL13A1 COL14A1 COLGALT1 P3H2 COL11A1 P3H1 COL11A2 COL12A1 PCOLCE P3H3 COL19A1 COL10A1 PCOLCE2 SERPINH1 COL28A1 CRTAP COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 ADAMTS14 COL3A1 COL2A1 COL4A2 COL5A1 COL4A1 COL7A1 COL6A2 BMP1 COL5A3 TLL2 COL4A4 TLL1 COL5A2 COL6A1 COL4A3 COL4A6 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection AP1G1 RAC1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 PAK2 ATP6V1H NMT2 NPM1 XPO1 LCK FYN PPIA CD4 RCC1 DOCK2 NMT1 AP2A1 CCR5 CCNK RANBP1 AP2A2 CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB AP2M1 ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 HCK RBX1 TAF11 CD8B ELOA2 ELMO1 SSRP1 NEDD4L AP2S1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 AP2B1 LIG4 XRCC4 CXCR4 NUP205 POM121 NUP188 PSIP1 AAAS POM121C NUP42 NUP62 FURIN TPR BANF1 NUP88 RAE1 KPNA1 NUP214 NDC1 LIG1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 ARF1 NUP107 NUP160 KPNB1 NUP85 SEC13 NUP133 PDCD6IP RANGAP1 CHMP4C CHMP4B CHMP3 CHMP4A PSMD8 CHMP6 CHMP7 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 NUP43 PSMA5 PSMA6 PSMA3 CHMP2B PSMA4 CHMP2A PSMA1 PSMA2 RANBP2 UBA52 PSMD12 RAN PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NUP37 ADRM1 FEN1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CUL5 TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 CHMP5 XRCC6 XRCC5 CD28 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants ALK IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID CHUK IKBKB IKBKG NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation ADCYAP1R1 NTRK1 NTRK2 ADCYAP1 ADORA2A FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF9 FGF20 FGF23 FGF16 SOS1 FGF19 FGF18 FGFR4 NRAS FRS3 HRAS KLB FRS2 FGF1 FGF2 PTPN11 FGF4 FGF6 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism ACAT1 BDH1 OXCT1 OXCT2 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism ITPA RRM2 SAMHD1 DTYMK AK1 AK2 AK4 GLRX AK5 AK6 AK7 AK8 AK9 NUDT13 RRM1 NUDT16 NME3 CTPS2 ADPRM NUDT5 NME4 CTPS1 DCTD NME6 CMPK1 DCTPP1 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP ENTPD1 ENTPD5 ADA NT5C AGXT2 NT5C1A DPYS DPYD NT5M UPP2 UPP1 UPB1 TYMP NME2 GMPS NME1 IMPDH1 GUK1 IMPDH2 HPRT1 NUDT15 NT5E XDH CDA RRM2B GDA PFAS DNPH1 ATIC PPAT TK2 ADSL ENTPD2 ENTPD3 ENTPD4 ENTPD6 TK1 CAD ENTPD7 TYMS ENTPD8 UMPS GART NT5C2 PAICS DHODH UCKL1 TXN UCK2 UCK1 TXNRD1 PUDP NT5C1B ADSS1 ADSS2 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SZT2 SAMTOR SEH1L NPRL2 NPRL3 GCN1 WDR59 EIF2AK4 RPTOR FLCN MIOS ITFG2 IMPACT KPTN DEPDC5 WDR24 RRAGA SH3BP4 RRAGC FNIP1 RRAGB FNIP2 RRAGD KICS2 CASTOR1 CASTOR2 TCIRG1 SLC38A9 ATP6V1E1 RHEB ATP6V1E2 LAMTOR2 ATP6V0B LAMTOR1 ATP6V1G1 CEBPB LAMTOR4 ATP6V0E1 LAMTOR3 ATP6V1G2 RPL4 LAMTOR5 RPL5 RPL30 RPL3 RPL32 ATP6V1B2 RPL31 ATP6V0D1 RPL34 ATP6V0C RPL10L ATP6V0D2 RPL10A RPL8 RPL6 ATP6V1B1 RPL7 ATP6V1A RPS15 CEBPG RPS14 RPS17 RPS16 RPL18A ATP6V1H RPS19 RPS18 ATP6V0E2 RPL36AL ATP6V1G3 RPL36 ATP6V1D ATP6V1C1 ASNS RPL35 ATP6V1F RPL38 ATP6V1C2 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 ATF2 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 MLST8 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 SEC13 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 SESN2 RPL36A RPS27L RPS15A RPL14 MTOR RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A ATF4 TRIB3 ATF3 SESN1 DDIT3 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation TNFRSF10B CASP8 TNFRSF10A TNFSF10 FAS FASLG TRAF2 TICAM2 TICAM1 TLR4 LY96 CD14 RIPK1 FADD TRADD RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling NOTCH1 EP300 JAG1 RBPJ MAML2 CREBBP MAML1 RUNX3 KAT2B KAT2A MAMLD1 SNW1 HES1 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly PRKACA A2M ZDHHC8 PRKACG ABCA1 PRKACB APOA1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism ST3GAL1 CHST5 ST3GAL2 GALNS ST3GAL3 CHST2 OGN CHST3 OMD B4GALT2 B4GALT3 B4GALT1 HEXB HEXA SLC35D2 GNS GLB1L3 GLB1L2 B3GNT3 FMOD GLB1L ST3GAL6 GLB1 B4GAT1 B4GALT6 KERA B4GALT4 B4GALT5 CHST6 PRELP ACAN B3GNT7 B3GNT4 LUM CHST1 B3GNT2 ST3GAL4 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification NGRN MTERF3 FASTKD2 SLIRP RPUSD4 MTPAP RPUSD3 TRMT61B TRUB2 LRPPRC RCC1L BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds GSTT2 CYP1A2 GSTT1 OPLAH CNDP2 HPGDS TPST2 ESD CHAC2 CHAC1 TPST1 GSTT2B GSTM4 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT UGT1A10 GSTA5 ABHD10 GSTA4 UGT2B10 GSTM5 UGT2B11 UGT2B15 UGT2B17 SLC35D1 UGT3A2 UGT3A1 NAT1 NAT2 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGDH UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGT1A6 HEMK2 NNMT MTRR AHCY GSTO1 MTR MAT1A MAT2B COMT TRMT112 AS3MT MAT2A GLYATL3 GLYATL2 GSS GLYATL1 ACSM2A ACSM5 ACSM4 GLYAT UGP2 GGT7 PODXL2 GGT6 ABHD14B MGST3 SULT1A1 MGST1 SULT1C2 MGST2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 GGT3P SULT1A4 SULT4A1 SULT1A3 SULT1A2 SULT2A1 SULT1C4 GSTK1 ACSM1 ACSM2B UXS1 GSTM1 TPMT GSTA2 GSTA1 SLC35D2 UGT1A3 GGT1 GSTP1 GGT5 GSTA3 GCLC GCLM AKR1A1 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR1 TGFBR2 TGFB1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation FGF9 WT1 GATA4 DMRT1 SOX9 ZFPM2 PTGDS SRY NR5A1 DHH AMH TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template UBE2L6 SPRTN TRIM25 VCP UBA52 POLK POLE POLH RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 ISG15 RPS27A RCHY1 UBA7 NPLOC4 PCNA POLD3 POLD4 POLD1 POLD2 UFD1 RPA1 RPA2 USP10 POLE4 REV3L PCLAF POLI RPA3 USP43 POLE2 REV1 POLE3 MAD2L2 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin HSP90AA1 EEF2 CD9 HSP90AB1 TXNRD1 HBEGF LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants FLT3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi MGAT1 MAN1A1 MANEA MAN1A2 MAN1C1 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway IL1RL2 IL36A IL36B IL36G IL1F10 IL36RN PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria PAH SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC ABHD3 PCTP CEPT1 MFSD2A PCYT1B CHKB PCYT1A CHKA STARD10 PHOSPHO1 PEMT CHPT1 ACHE SLC44A5 BCHE SLC44A3 SLC44A4 CSNK2A1 SLC44A1 CSNK2A2 SLC44A2 CSNK2B CHAT LPCAT1 LPIN1 STARD7 LPIN2 LPIN3 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation FGF22 FGFBP1 FGF1 FGFBP2 FGF2 FGF10 FGFBP3 FGF3 FGF7 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PSMA5 PRKAG1 PSMA6 PRKAG2 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PRKAG3 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 CD274 VCP SEL1L RNF185 PRKAB2 PRKAB1 PRKAA1 PRKAA2 RNF5 ERLEC1 PSMD8 PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion PPIA BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 PRKCB AP2A1 DVL2 AP2S1 FZD4 AP2A2 CLTC ARRB2 CLTA PRKCA AP2M1 AP2B1 CLTB WNT5A PRKCG REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PPARGC1B PSMD11 PSMD14 PSMD13 CUL1 PSMA7 CBFB TWIST1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 DLX5 PSMC6 DLX6 PSMC3 PSMC4 PSMC1 PSMC2 HIVEP3 STAT1 SKP2 NR3C1 ESR1 ESRRA SMURF1 GSK3B NKX3-2 MSX2 PPARGC1A WWP1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion HGS RAB5A VPS33B RAB7A UBB CORO1A UBA52 UBC RPS27A NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR KDR NRP2 NRP1 FLT1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation NOS3 NMT1 CALM1 NMT2 CYB5B HSP90AA1 LYPLA1 CYGB DDAH1 ZDHHC21 CAV1 SPR AKT1 TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling CHUK TNF UBA52 STUB1 UBE2D1 TNFRSF1A RBCK1 USP2 UBB IKBKE OPTN UBC RPS27A RACK1 UBE2D2 RNF31 MIB2 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 ULK1 TBK1 MAPKAPK2 ADAM17 SPPL2B SPPL2A SMPD3 SMPD2 CLIP3 TAX1BP1 NSMAF OTULIN TRADD UBE2L3 CASP8 TAB3 TAB2 TAB1 TRAF2 UBE2D3 IKBKB BIRC2 BIRC3 XIAP IKBKG RIPK1 FADD MAP3K7 BAG4 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing RCE1 GOLGA7 PDE6D CALM1 PRKCQ KRAS PRKG2 ARL2 ZDHHC9 ICMT NRAS LYPLA1 HRAS BCL2L1 ABHD17C USP17L2 FNTA ABHD17B FNTB ABHD17A DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) CBX6 PHC2 NFATC2 GATA3 PHC1 MTA2 CBX4 CBX2 ASH2L HDAC10 HDAC11 JUN PHC3 MAML2 MAML1 MEN1 MAF BMI1 RING1 FOS RNF2 NOTCH1 NOTCH2 MTA1 HDAC1 BATF MTA3 IL4R HDAC4 SATB1 SMARCA4 SNW1 IL4 IL13 KMT2A IRF4 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 DPY30 MBD3 WDR5 KLF13 STAT5A EP300 STAT5B GATAD2B TBL1X GATAD2A RBPJ POU2F2 HDAC5 HDAC2 CREBBP ETS1 POU2F1 HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 CHD4 RBBP4 CHD3 RBBP5 YY1 IL5 RBBP7 STAT6 CBX8 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation FGF23 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed SUMO2 SENP5 SENP2 SENP1 SUMO1 SUMO3 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport TTPA FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes FOXG1 CDKN1A FOXO4 CDKN1B FOXO1 FOXO3 PCBP4 CCNG2 RBL2 GADD45A SMAD2 MSTN CAV1 SMAD4 SMAD3 KLF4 BTG1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation RARS2 AARS2 MARS2 PARS2 DARS2 HARS2 YARS2 FARS2 KARS1 WARS2 GARS1 LARS2 SARS2 PPA2 NARS2 TARS2 QARS1 IARS2 VARS2 CARS2 EARS2 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency ATF4 TRIB3 ATF3 EIF2S3 EIF2S2 EIF2S1 GRB10 CEBPG PPP1R15A CHAC1 EIF2AK1 ASNS DDIT3 ATF5 CEBPB NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay TENT4B PAPOLG ZC3H18 RBM7 ZFC3H1 DXO DIS3 XRN2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC10 EXOSC2 EXOSC1 SRRT NCBP1 NCBP2 WDR82 MPHOSPH6 MTREX RBM27 TENT4A ZCCHC8 ZCCHC7 RBM26 YTHDC1 C1D ZC3H4 PABPN1 ZC3H3 YTHDC2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization FLT4 VEGFD KDR PGF VEGFB FLT1 VEGFC VEGFA PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL PPP2CA PPP2CB PTPN6 PPP2R1B PPP2R5E PPP2R1A APOB LRP8 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PLA2G4A FGR PECAM1 MAPK14 PTPN11 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2AC6 H2AC7 H2AX RBM7 TASOR PPHLN1 H3-3B H2AC19 H2AC14 H3C8 H2BC12L ATF7IP H2AJ SETDB1 H2BC26 H2BC21 MTREX H3C15 H2BC17 MORC2 H2BC12 H2BC13 H2BC14 H2BC15 EHMT2 H2BC9 EHMT1 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 MPHOSPH8 H4C9 ZCCHC8 H2AB1 H2AZ2 H2AC20 H2AC8 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins ITGA2B ITGB3 CRK FN1 PTK2 RAP1B FGB FGA RAP1A VWF FGG APBB1IP TLN1 SRC BCAR1 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination ATM H2AX SPO11 TEX15 MSH4 DMC1 MSH5 PSMC3IP MND1 MLH3 H3-3B H3C8 H2AJ H3C15 MLH1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 H2BC1 CDK4 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 MRE11 BRCA1 BRCA2 FIRRM PRDM9 NBN H2AC19 H2AC14 H2BC12L H2BC26 TOP3A H2BC21 RAD51C H2BC17 BLM H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 FIGNL1 RBBP8 H4C9 RPA1 RPA2 RAD50 H2AZ2 RAD51 RPA3 H2AC20 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CLOCK CSNK2A1 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin INHBB INHBA ACVR2A TGFBR3 INHA FSTL3 FST MAPK1 FOXH1 DRAP1 MAPK3 SMAD2 ACVR1C SMAD4 SMAD3 ACVR1B ACVR2B INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing EXOC1 INS MYO5A PCSK2 RAB27A PCSK1 MYRIP ERO1B KIF5C KIF5B KIF5A SLC30A8 SLC30A5 CLTRN EXOC8 CPE EXOC7 VAMP2 STX1A P4HB EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 HTR1D HTR6 HTR1A HTR7 HTR1B HTR5A DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System TGFA EGF AREG FGF10 PRL ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans ITGA2B COL9A2 LAMA2 LAMA1 LAMB2 LAMA4 LAMA3 LAMB1 LAMC1 VTN SERPINE1 SPARC NCAN HAPLN1 TNN BGN TNR DCN MUSK ASPN BCAN MATN1 VCAN MATN4 FMOD TNXB AGRN LRP4 DSPP ITGB5 ITGA9 NCAM1 TNC COMP IBSP ITGAX TGFB2 DMP1 ITGAV DAG1 HSPG2 PTPRS TGFB1 ITGB6 TGFB3 ITGA8 ITGB1 ITGB3 MATN3 ITGA2 ITGA7 ACAN COL9A1 LUM COL9A3 LAMA5 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC17A6 SLC25A18 SLC6A19 SLC25A22 SLC6A15 SLC6A13 SLC6A5 SLC6A14 SLC6A11 SLC22A2 SLC6A2 SLC22A1 SLC6A1 SLC6A4 SLC32A1 SLC6A3 SLC17A7 SLC6A20 SLC17A8 SLC6A7 SLC6A9 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation ADAM19 ADAM15 ADAM12 SH3PXD2A SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 FGF9 FGF20 FGF23 FGF16 SOS1 FGF19 FGF18 FGFR4 NRAS HRAS KLB FGF1 FGF2 FGF4 FGF6 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones DNAJB11 SULT1A3 EXTL2 PREB EXTL3 GOSR2 ADD1 FKBP14 MYDGF TATDN2 SERP1 SEC31A GFPT1 TSPYL2 DDX11 WIPI1 PDIA6 PDIA5 ATP6V0D1 ERN1 CTDSP2 KDELR3 SHC1 HSPA5 DCTN1 CXXC1 EXTL1 SSR1 DNAJB9 ZBTB17 KLHDC3 WFS1 EDEM1 YIF1A SRPRA ACADVL SRPRB TPP1 HDGF GSK3A PLA2G4B LMNA HYOU1 CUL7 PPP2R5B SYVN1 ARFGAP1 DNAJC3 TLN1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI PCNA UBA52 RFC5 RFC3 RPA1 RPA2 RFC4 UBB RFC1 REV3L RFC2 UBC RPA3 POLI RPS27A REV1 MAD2L2 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening H2AC6 H2AC7 H2AX H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 UBTF H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 MAPK3 H4C9 MBD2 H2AB1 H2AZ2 H2AC20 H2AC8 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers CBX6 PHC2 EZH2 PHC1 CBX4 CBX2 PHC3 RAC1 MDM2 BMI1 RING1 VAV1 SRC PIP5K1A RNF2 PIP5K1B TGFA MET RICTOR SUZ12 NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 PLCG1 CD86 EGF FRS2 CD80 AREG CD19 PRKCE THEM4 NRG2 NRG3 NRG4 ATF2 HDAC3 HGF PRR5 GSK3B PIK3CD PIK3CB PIK3CG PIP5K1C MLST8 EED PDPK1 EGR1 IRAK1 PIK3CA LCK CHD4 RBBP4 CHD3 FYN TRAF6 RBBP7 RHOG PTPN11 MTOR TNRC6C INS TNRC6A CALM1 SALL4 MTA2 TNRC6B REST JUN PRKACG PRKACB FOXO3 PIP4K2A PIP4K2B PDGFRA PDGFB KIT IL33 RAC2 HDAC1 IL1RL1 SNAI2 ADCY9 PRKAR1B PRKAR2B TP53 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 PRKAR2A ADCY6 ADCY5 CAMK4 KDM1A SNAI1 PREX2 TRIM27 USP13 TNKS TNKS2 WWP2 RNF146 FRK OTUD3 RCOR1 RPTOR TSC2 RRAGA RRAGC USP7 RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CDKN1A EREG CDKN1B BTC EPGN HBEGF FLT3 PRKCG KPNA2 PPP2R1B PPP2R1A NBEA EGFR KLB IRS1 IRS2 MBD3 FGF1 BAD FGF2 CASP9 FGF3 NRG1 FGF4 FGF6 FGF7 CAMKK1 FGF9 CAMKK2 FGF20 GATAD2B FGF23 PPP2R5E GATAD2A FGF22 GAB2 FGF16 FGF19 FGF18 PPP2R5B HDAC5 FGFR4 PPP2R5A FGF10 PPP2R5D HDAC2 PPP2R5C HDAC7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 PML PPP2CA CHUK PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYD88 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PDGFRB ADRM1 TRAT1 SEM1 IRAK4 NTRK3 PIK3AP1 PSMC5 IER3 SGK1 PSMC6 PHLPP2 PSMC3 PHLPP1 PSMC4 FLT3LG PSMC1 ATN1 FOXO6 PSMC2 MAF1 FOXO4 FOXO1 RPS6KB2 MTA1 MTA3 ESR1 NEDD4 AHCYL1 GSK3A ESR2 PPARG NR4A1 PRKACA PDE1C PDE1B PDE1A GRK2 NR2E1 PRKCD PRKCA CAMK2B CAMK2D CAMK2A ITPR1 MECOM ITPR2 PTEN AKT2 ITPR3 AKT3 PRKAR1A AKT1 ERBB2 STRN CAMK2G CSNK2A1 CSNK2A2 CSNK2B TRIB3 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR MOV10 AGO3 AGO4 AGO1 MKRN1 AGO2 CD28 CBX8 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism PHKB CALM1 UBA52 PHKA1 PHKA2 PPP1R3C NHLRC1 AGL UBB UBC PGM1 RPS27A GYG2 GYG1 EPM2A PYGB AKR1E2 GBE1 PYGM PYGL GYS2 GYS1 UGP2 GAA PHKG1 PHKG2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants PDGFRA REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2CA PPP2CB ATM PPP2R1B PPP2R1A PHF20 UBA52 CHEK2 TP53 MDM2 MDM4 USP7 CCNG1 USP2 CDK1 PRDM1 PRR5 AKT2 UBB AKT3 CCNA2 UBC AKT1 CCNA1 RPS27A MLST8 PDPK1 SGK1 MAPKAP1 RICTOR CDKN2A PPP2R5C RNF34 DAXX RFFL CDK2 MTOR DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells EGF FGF2 FGF10 FGF4 FGF7 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis ENO3 ALDOB ENO4 ALDOA G6PC2 G6PC3 G6PC1 GAPDHS PC PGK1 SLC37A4 PCK2 GAPDH FBP1 FBP2 PCK1 TPI1 PGAM1 PGAM2 GPI PGK2 ENO1 ENO2 SLC37A1 ALDOC MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades FN1 RAC1 IL6 JAK1 CDK1 SRC PAK1 TGFA MET PAK3 PAK2 SHC2 SHC3 ICMT SHC1 YWHAB NRAS RAP1A FRS3 MAPK1 GRIN2B HRAS RALGDS MAPK3 MAP2K1 MAP2K2 EGF FRS2 BRAF AREG BCL2L1 MAPK12 PRKCQ RAG2 SOS1 RAG1 NRG2 NRG3 RASGRP4 NRG4 HGF GFRA1 PIK3CB XPO1 GDNF PDE6D PIK3CA IL2 IL3 CDC42 FYN CSK RASGRP1 PTPN11 RASGRP3 TNRC6C CDC14A TNRC6A CALM1 TNRC6B JUN KRAS PRKACG PRKACB FOXO3 KALRN PDGFRA PDGFB RBX1 KIT PPP1CB MARK3 RET GOLGA7 CDC42EP5 CDC42EP3 CDC42EP2 PTK2 ZDHHC9 ARL2 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 PPP5C NEFL NCOA3 FNTA CSF2 FNTB ITGA2B SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 IL2RG JAK3 RASAL3 DAB2IP NF1 KBTBD7 TYK2 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 LAMTOR2 LAMTOR3 EREG SPTAN1 CCND3 BTC SPTB EPGN HBEGF NCAM1 RANBP9 FLT3 DUSP16 PPP1CC PPP2R1B PPP2R1A EGFR RASGRF2 LYPLA1 RASGRF1 HSPB1 KLB DLG1 IRS1 DLG3 DLG4 IRS2 FGF1 FGF2 FGF3 NRG1 ABHD17C USP17L2 FGF4 FGF6 ABHD17B FGF7 ABHD17A RCE1 FGF9 FGF20 FGF23 PPP2R5E FGF22 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A FGF10 PPP2R5D PPP2R5C PSMD8 PSMD6 IL6R PSMD7 PSMD2 DUSP10 PSMD3 DUSP5 PSMD1 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PPP2CA PTPN3 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DUSP4 PDGFRB ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 FLT3LG PSMC1 PSMC2 FOXO1 WDR83 PTPRA RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 SHOC2 SEPTIN7 CDC14B ARTN RASGEF1A ETV4 GFRA3 IGF2BP1 MAPK6 GFRA2 MAPK4 ANGPT1 GFRA4 TEK NRTN PTPN7 PRKACA PSPN PRKG2 CAMK2B CAMK2D CAMK2A MYC ERBB2 CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 PIK3R2 IQGAP1 PIK3R1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 IL5RA CNKSR1 CSF2RB MAPKAPK5 RAF1 CSF2RA TLN1 IL5 MOV10 VCL IL2RB AGO3 MAP3K11 IL3RA AGO4 AGO1 AGO2 DNAJB1 IL2RA COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway ITGA2B ANO5 APP F5 F8 SERPINE1 GPC1 F12 KLKB1 GPC3 GPC2 PRTN3 GPC5 F7 GPC4 F9 GPC6 PROZ AGRN GP1BA F3 PROS1 SERPINC1 F10 F2 PROC SERPINE2 SERPINA5 THBD SERPING1 SMPD1 PF4V1 CD177 PROCR F11 F13B F13A1 GP9 GP1BB HSPG2 GP5 F2R SDC4 SDC2 SDC3 KNG1 SERPINA10 SDC1 ITGB3 ADAMTS13 FGB FGA SERPIND1 VWF FGG PF4 ANO6 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs PRKAA2 PRKAB1 CAMKK2 PRKAG1 CALM1 PRKAG2 PRKAG3 PRKAB2 PRKAA1 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A PPP2R5B PPP2R5A PPP2R5D PPP2R5C LCK CTLA4 LYN YES1 CD86 AKT2 FYN CD80 AKT3 AKT1 PTPN11 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures ATM MUS81 MRE11 BRCA1 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM NBN GEN1 RMI2 SLX1B RMI1 TOP3A SPIDR SEM1 RAD51B RAD51D RAD51C DNA2 BLM RTEL1 RAD51AP1 WRN BRIP1 SLX4 FIGNL1 RBBP8 BARD1 XRCC2 XRCC3 PALB2 RAD50 RAD51 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus BANF1 LIG4 KPNA1 XRCC4 XRCC6 XRCC5 HMGA1 PPIA PSIP1 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS SFTPB FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation FGF9 FGF20 FGF23 TGFBR3 GIPC1 ANOS1 FGF1 FGF2 FGF4 FGF6 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels ABCC9 KCNJ1 GNG10 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ11 KCNJ8 ABCC8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression EPAS1 NR3C1 PTK6 PELP1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition RPS2 EIF2S3 EIF2S2 EIF2S1 FAU EIF4E EIF4B RPS27A EIF4G1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 EIF5 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 PPP2CA PPP2CB PPP2R1A SOS1 UBA52 UBB FGF1 FGF2 UBC FGF4 RPS27A CBL FGF9 FGF20 FGF23 FGF16 MKNK1 FGF18 SPRY2 PIK3R1 PIK3CA NRAS GAB1 MAPK1 FRS3 HRAS GALNT3 MAPK3 PLCG1 FRS2 BRAF PTPN11 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX3 ACOT8 HSD17B4 ACOXL ACOX2 AMACR CRAT CROT DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding OGG1 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism B3GALT6 ST3GAL3 OGN CHST3 PAPSS2 OMD GPC1 B4GALT1 HSPG2 GPC3 GPC2 SDC4 HEXB NCAN SDC2 GPC5 HEXA SDC3 GPC4 BGN GPC6 DCN BCAN VCAN FMOD AGRN CHST14 CSPG5 EXT1 EXT2 CSPG4 SDC1 KERA B4GALT7 SLC26A2 CHST6 PRELP ACAN CHSY1 B3GAT3 LUM RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade FN1 JAK1 SRC TGFA MET SHC2 SHC3 ICMT SHC1 YWHAB NRAS RAP1A FRS3 MAPK1 GRIN2B HRAS RALGDS MAPK3 MAP2K1 MAP2K2 EGF FRS2 BRAF AREG BCL2L1 MAPK12 PRKCQ SOS1 NRG2 NRG3 RASGRP4 NRG4 HGF GFRA1 PIK3CB GDNF PDE6D PIK3CA IL2 IL3 FYN CSK RASGRP1 RASGRP3 CALM1 KRAS PDGFRA PDGFB RBX1 KIT PPP1CB MARK3 RET GOLGA7 PTK2 ZDHHC9 ARL2 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 PPP5C NEFL FNTA CSF2 FNTB ITGA2B SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 IL2RG JAK3 RASAL3 DAB2IP NF1 KBTBD7 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 LAMTOR2 LAMTOR3 EREG SPTAN1 BTC SPTB EPGN HBEGF NCAM1 RANBP9 FLT3 DUSP16 PPP1CC PPP2R1B PPP2R1A EGFR RASGRF2 LYPLA1 RASGRF1 KLB DLG1 IRS1 DLG3 DLG4 IRS2 FGF1 FGF2 FGF3 NRG1 ABHD17C USP17L2 FGF4 FGF6 ABHD17B FGF7 ABHD17A RCE1 FGF9 FGF20 FGF23 PPP2R5E FGF22 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A FGF10 PPP2R5D PPP2R5C PSMD8 PSMD6 PSMD7 PSMD2 DUSP10 PSMD3 DUSP5 PSMD1 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PPP2CA PTPN3 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DUSP4 PDGFRB ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 FLT3LG PSMC1 PSMC2 WDR83 PTPRA RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 SHOC2 ARTN RASGEF1A GFRA3 GFRA2 ANGPT1 GFRA4 TEK NRTN PTPN7 PSPN PRKG2 CAMK2B CAMK2D CAMK2A ERBB2 CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 PIK3R2 IQGAP1 PIK3R1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 IL5RA CNKSR1 CSF2RB RAF1 CSF2RA TLN1 IL5 VCL IL2RB MAP3K11 IL3RA IL2RA RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 TRMT10C PRORP RCC1L NGRN MRM1 HSD17B10 MRM2 MRM3 ELAC2 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 CDH1 CTNNB1 MAPK8 BMX PAK2 CDKN2A YWHAB STAT3 MAPK1 MAPK3 TP73 BCL2 BCL2L1 PRKCQ LY96 YWHAG IRF1 TLR4 YWHAQ PPP3R1 NMT1 YWHAE FASLG C1QBP LMNB1 UNC5A BCL2L11 DAPK1 MAGED1 UNC5B DAPK2 DAPK3 YWHAH APPL1 YWHAZ PTK2 TP53 AVEN DIABLO CARD8 UACA ROCK1 DCC CDC37 VIM BCAP31 FNTA KPNA1 SFN CASP7 DBNL GAS2 MAPT ADD1 PLEC BBC3 SPTAN1 E2F1 APC TFDP1 TFDP2 GSN KPNB1 BID MLKL BAD CASP9 TRADD HMGB1 UBE2L3 CASP8 CASP5 DFFB CASP4 DFFA FLOT1 TNFSF10 HMGB2 CASP1 FLOT2 TP63 PDCD6IP RIPK3 IL18 TRAF2 DYNLL1 IL1A IL1B IRF2 PELI1 HSP90AA1 DYNLL2 CHMP4C CHMP4B CHMP3 CHMP4A APIP PSMD8 CHMP6 CHMP7 PSMD6 BIRC2 PSMD7 BIRC3 PSMD2 PRKN PSMD3 XIAP PSMD1 SDCBP RIPK1 FADD BAK1 ELANE GSDMD TNFRSF10B GZMB PSMA5 TNFRSF10A PSMA6 ITCH PSMA3 CHMP2B PSMA4 CHMP2A PSMA1 FAS PSMA2 CYCS UBA52 BAX STUB1 PSMD12 OGT GSDME PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 TICAM2 TP53BP2 PSMB7 TICAM1 PSMB4 PSMB5 CD14 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DSP TJP1 OCLN CASP3 DSG1 SATB1 PKP1 DSG2 DSG3 TJP2 PMAIP1 CLSPN PRKCD OMA1 STK24 CASP6 STK26 OPA1 DNM1L ACIN1 PPP1R13B AKT2 AKT3 AKT1 APAF1 ARHGAP10 PPP3CC BMF PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling UBE2L6 CHUK PPP2CA HERC5 PPP2CB ADAR EIF2S3 EIF2S2 EIF2S1 HSPA1A SNCA CDK1 CENPX CENPS STAT1 HSPA1B UBE2I STAT3 SUMO1 HSPA8 PPP2R1B FANCC PPP2R1A TRIM25 PTPN2 DUS2 MAVS TP53 NPM1 FAAP100 EIF2AK2 ISG15 SPHK1 PRKRA TARBP2 PPP2R5A NCK1 FAAP24 FAAP20 HSPA1L ILF3 ILF2 DNAJC3 IKBKB ARIH1 DHX9 FANCM FANCL FANCA HSPA2 FANCB IKBKG FANCE FANCG MAP2K6 FANCF TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling DOK2 SOS1 PIK3R2 PIK3R1 PIK3CA SHC1 GRB7 NRAS ANGPT4 HRAS ANGPT2 GRB14 ANGPT1 TEK PIK3CB PTPN11 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina CASP6 LMNB1 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate AMY2B AMY1A TREH AMY1B AMY1C CHIT1 SI CHIA MGAM LCT AMY2A C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) UBE2M UBE2D1 PAK1 PAK3 PAK2 UBE2D2 NRAS HRAS CDC34 UBE2V1 NFKB2 MUC12 MUC13 MUC15 MAP3K14 MUCL1 MUC3A ICAM2 MUC5AC ICAM3 MUC3B RELB RPS6KA5 CD209 UBE2N CASP8 EP300 TAB3 TAB2 PDPK1 TAB1 MUC1 CREBBP MUC2 IL1B MUC7 MUC4 MUC6 MUC16 PSMD8 MUC17 IKBKB PSMD6 MUC19 FYN PSMD7 TRAF6 PSMD2 MUC5B PSMD3 MUC20 PPP3CA PSMD1 MUC21 PPP3CB IKBKG BTRC MAP3K7 SKP1 PPP3R1 NFATC3 CHUK NFATC2 FBXW11 NFATC1 PSMA5 CALM1 FCER1G PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRKACG UBA52 CARD11 PSMD12 PRKACB PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 AHCYL1 PLCG2 PRKACA SYK PRKCD ITPR1 CLEC10A CLEC4A ITPR2 CLEC4C PYCARD CLEC4D ITPR3 CLEC4E CLEC7A CLEC6A CARD9 LYN RAF1 UBA3 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 EIF5 RPS13 EIF5B RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi NOTCH1 NOTCH2 FURIN TMED2 ST3GAL3 LFNG NOTCH3 SEL1L NOTCH4 RFNG B4GALT1 MFNG RAB6A ST3GAL6 ATP2A3 ATP2A2 ATP2A1 ST3GAL4 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB HADHA ACADM ECHS1 MECR HADH GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors GGCX GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants HSP90AA1 CDC37 ERBIN ERBB2 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome MEFV HMOX1 CASP1 APP NLRP3 PSTPIP1 NFKB2 RELA P2RX7 PYCARD TXNIP TXN HSP90AB1 SUGT1 PANX1 NFKB1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PLXNA2 PLXNA3 FES SEMA3A RAC1 RND1 FARP2 RRAS PLXNA1 NRP1 FYN TLN1 PLXNA4 PIP5K1C DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) SLC6A19 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT4 CNOT6 CNOT7 TNKS1BP1 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 EIF4E EIF4B PABPC1 BTG4 ZFP36L2 PABPN1L EIF4G1 DICER1 EIF4A2 EIF4A1 PAIP1 CNOT10 EIF4A3 CNOT11 CNOT6L AGO2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB CAMK2B CAMKK1 CAMK2D CAMKK2 CAMK2A CALM1 CAMK4 CAMK2G KPNA2 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A LDB1 PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A COL4A5 RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 ELOB RPL26L1 PSMD14 PSMD13 ELOC SLIT2 PSMA7 ROBO1 NCBP1 PSMB6 NCBP2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4A3 CASC3 MAGOH RBM8A DAG1 HOXA2 ISL1 GSPT2 GSPT1 UPF3B UPF3A MAGOHB ROBO2 RNPS1 UPF2 PABPC1 ZSWIM8 MSI1 CUL2 LHX3 LHX2 LHX4 LHX9 USP33 ETF1 SLIT1 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling IL1RL1 IL33 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins TACR2 TACR3 TACR1 TAC3 TAC1 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism GPT RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription KCTD6 CBFB RUNX1 ESR1 GPAM AXIN1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation CTNNB1 GATA4 PAX6 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 FFAR4 ISL1 LEP FFAR1 GCG GNG13 GRP GPR119 GNB1 TCF7L2 GNAT3 DPP4 GNB3 GIP CDX2 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 EEF1A1 RPL39 RPS10 RPS13 EEF2 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription RB1 ZCRB1 VHL DDX5 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate SLC35D1 UGP2 SLC35D2 UXS1 UGDH MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands CRH DLL1 HDAC1 SIN3A SST BDNF CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants PPP1CC SHOC2 ARAF PPP1CB RAF1 BRAF YWHAB MRAS THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) F2RL2 F2RL3 GNA13 GNA12 GNAQ GNG10 F2R GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ARRB1 ARRB2 GNA14 GNGT1 GNA15 GNA11 MAPK1 GNGT2 GNG12 MAPK3 GNG11 GNG13 F2 GNB2 GNB1 GNB4 GNB3 GNB5 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 MAGT1 JAK1 HLA-A ANO10 B2M TUFM IFNB1 VHL YWHAB STAT1 TUSC3 CTSL TBK1 TMEM258 IRF3 VCP UBE2V1 GEMIN2 OST4 SNRPD2 SNRPD1 SNRPD3 OSTC STT3A CSNK1A1 SNRPG STT3B GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 GSK3B CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 UBE2N YWHAG TAB3 TAB2 PDPK1 TAB1 IRAK1 DDOST CREBBP DAD1 TRAF6 YWHAQ PTPN11 PTPN6 YWHAE BECN1 UVRAG MAP1LC3B ISCU YWHAH YWHAZ GJA1 ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 ZDHHC8 CAV1 ZDHHC2 ZDHHC3 IFNA5 IFNA4 FUT8 IFNA7 GANAB IFNA6 MAN2A1 IFNA1 MGAT5 ST3GAL4 IFNA2 IFNA8 MGAT1 IFIH1 MGAT2 GOLGA7 RNF135 TRIM25 ST3GAL1 ST3GAL2 IFNA21 ST3GAL3 IFNA14 ST6GAL1 IFNA16 LARP1 EDEM2 IFNA17 MOGS SIKE1 ZDHHC11 MAVS IFNA10 MGAT4C ZDHHC9 RIGI SRPK2 MGAT4A SRPK1 MGAT4B HSPG2 MAN1B1 ST6GALNAC3 ST6GALNAC4 SDC4 SDC2 SDC3 VPS33A VPS33B ZCRB1 NRP1 G3BP1 G3BP2 HSP90AB1 SDC1 CNBP NLRP3 DDX5 SFTPD NLRP12 NUP205 POM121 IL17F IL17A NUP188 AAAS POM121C NUP42 IFNAR1 NUP62 FURIN TPR NUP88 RAE1 NUP214 SFN NDC1 NUP210 NUP155 GPC1 NUP153 NUP93 TYK2 GPC3 NUP50 NUP35 GPC2 NUP54 GPC5 GPC4 VPS39 STAT2 VPS18 GPC6 ATG14 VPS11 VPS16 AGRN TMPRSS2 ACE2 RB1 HAVCR1 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC SEC23A NUP107 RPS11 SAR1B KPNA2 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 SEC24B SEC24A RPS5 RPS6 RPSA VPS41 VPS45 NUP160 SEC24D SEC24C RPS4Y2 HLA-H RPS4Y1 HLA-C HLA-F NUP85 PIK3R4 HLA-G HLA-E ISG15 RPS26 TOMM70 RPS25 IL17RC RPS28 RPS27 IL17RA RPS29 TLR1 RPS20 TLR2 RPS21 SEC13 RPS24 RPS23 NUP133 PIK3C3 RPS4X HSP90AA1 CHMP4C CHMP4B RPS3A CHMP3 CHMP4A CHMP6 IKBKB CANX CHMP7 RPS27L IKBKG RPS15A MAP3K7 RPS3 CHUK RPS2 NUP43 CHMP2B CHMP2A RANBP2 UBA52 FAU HLA-B RIPK2 TRAF3 UBB IKBKE UBC RPS27A NUP37 PRMT1 TRIM4 NOD1 NOD2 TJP1 IRAK2 UBE2I SUMO1 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 AKT2 TLR8 TLR7 AKT3 AKT1 MASP1 MBL2 RPN2 RPN1 IRF7 ANO8 ANO9 STING1 ANO6 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription HEYL SP1 ILF3 SNAI1 PRDM8 ZEB2 BHLHE22 HOXC8 FOXF1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling UBA52 STUB1 NRG2 NRG3 EGFR NRG4 ERBIN AKT2 UBB AKT3 ERBB2 UBC AKT1 RNF41 NRG1 RPS27A CUL5 USP8 MATK EREG BTC HBEGF HSP90AA1 CDC37 PTPN18 EGF PTPN12 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases GYG2 GYG1 EPM2A G6PC3 GBE1 G6PC1 UBA52 GYS2 GYS1 PPP1R3C NHLRC1 GAA UBB SLC37A4 UBC RPS27A MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling SLC25A27 UCP3 SLC25A4 UCP2 SLC25A14 UCP1 PM20D1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling RAC1 RYK CTNNB1 CLTB PRKCG TCF7 RHOA PARD6A DAAM1 SCRIB CLTC RAC3 CLTA LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PPP3CA TCF7L2 PSMD1 PPP3CB TCF7L1 MAP3K7 PPP3R1 TNRC6C PRKCB NFATC1 PSMA5 TNRC6A CALM1 AP2A1 PSMA6 TNRC6B PSMA3 AP2A2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PRICKLE1 AP2M1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 AP2S1 PSMC4 PSMC1 PSMC2 RAC2 GNGT1 AP2B1 GNGT2 WNT5A SMURF2 SMURF1 GNAT2 PRKG2 PRKG1 PRKCA PLCB3 PFN1 PLCB1 PLCB2 NLK PDE6B GNG10 CAMK2A PDE6A GNG3 PDE6G ITPR1 GNAO1 GNG2 ITPR2 WNT11 GNG5 ITPR3 GNG4 GNG7 GNG8 WNT1 WNT4 FZD1 FZD3 DVL1 FZD2 DVL2 FZD5 WNT5B DVL3 FZD4 ROR1 ROR2 FZD7 ARRB2 FZD6 FZD8 GNG12 GNG11 GNG13 GNB2 MOV10 GNB1 AGO3 AGO4 GNB4 GNB3 VANGL2 AGO1 GNB5 AGO2 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome GLI3 PSMA5 PSMA6 PSMA3 PRKACA PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PSMD11 PRKACB PSMD14 PSMD13 CUL1 PSMA7 CSNK1A1 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SUFU PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling FGF9 FGF20 FGF23 FGF22 FGF16 SOS1 FGF18 FGF10 NRAS FRS3 HRAS FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FGF7 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin TTLL13 TTLL11 TTLL12 TTLL9 TTLL8 TUBA1C TUBA1B TUBA1A TUBB8 TUBB8B TUBB2B TUBB2A TTLL10 TPGS1 TUBA3E TTL TPGS2 SVBP TUBA3D AGTPBP1 TUBA3C LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 TUBB6 AGBL4 TUBB3 TTLL6 TUBB1 TUBB4B TTLL5 TUBB4A TTLL4 AGBL1 TTLL3 TTLL2 AGBL3 TTLL1 AGBL2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane MTMR10 MTMR12 PIK3C3 FIG4 PIKFYVE PIK3C2A INPP4A PI4K2B INPP4B MTMR2 PI4K2A VAC14 MTMR4 PIK3R4 MTM1 INPP5F DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 B4GAT1 LARGE1 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 SGCE LAMA3 SNTG2 SGCD LAMC2 SGCA SGCB LAMB1 LAMC1 DMD DAG1 SGCG SNTA1 DTNA DTNB HSPG2 SGCZ SSPN SNTB1 SNTB2 AGRN UTRN DRP2 LAMA5 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic H2AX GORASP1 H3-3B RAB1A H3C8 RAB1B USO1 H2AJ CCNA2 CCNA1 H3C15 CDKN2D CDKN2B CDKN2C CDKN2A KIF20A H2BC9 H3-4 H2BC8 H2BC5 FBXL18 H2BC3 H2BC1 SET KIF23 H2AB1 NEK2 H2AC8 H2AC6 CDC6 H2AC7 GSK3B H2BC26 H2BC21 YWHAG H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RBBP4 H2AZ2 CDC14A GTSE1 FKBPL PRIM2 PRIM1 POLA1 HJURP POLA2 MIS18BP1 ESCO1 ESCO2 PTK6 LIN54 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B TUBB6 TICRR TUBB3 TUBB1 PRKAR2B TUBA4B TUBA4A TP53 TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 NUP214 NDC1 LIG1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 ORC2 NEK9 NEK6 NEK7 HMMR KPNB1 PHLDA1 HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 KMT5A BTRC SKP1 PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 RAN PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 OPTN PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 CPAP PSMC5 MAX PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TOP2A UBE2I FOXM1 SUMO1 AKAP9 PRKCA FIRRM CCP110 CEP250 POLE CDK5RAP2 RFC5 CEP135 RFC3 EML4 CEP131 RFC4 CSNK1D RFC1 RFC2 DNA2 PCNA CEP70 POLD3 POLD4 CEP72 VPS4A CEP192 POLD1 E2F4 POLD2 CEP76 E2F5 CEP78 PLK4 E2F6 RPA1 ODF2 RPA2 POLE4 RPA3 POLE2 POLE3 ANAPC15 CEP57 ANAPC16 ANAPC7 CETN2 UBE2C PLK1 CEP164 UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A PCM1 CCNB1 CDC23 UBE2S CDC26 CNTRL CDC27 ARPP19 CDC16 NCAPH2 CDK1 NCAPG2 ANAPC4 NIPBL ANAPC5 ENSA ANAPC1 TNPO1 NCAPD3 ANAPC2 RAB2A CEP290 NINL CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL RAB8A GORASP2 OFD1 MCPH1 PPP2R2D TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 MAPK1 HAUS1 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E NEDD1 ALMS1 CEP41 CEP43 XPO1 EP300 ANKLE2 PTTG1 EMD MYBL2 LEMD3 RCC1 AURKA RRM2 YWHAE PPP1R12A CDC25C CDC25A CDC25B LMNB1 GOLGA2 SMC4 SPAST SMC2 CC2D1B SIRT2 TUBGCP2 NCAPG TUBB8 NCAPH IST1 VRK1 TUBGCP5 LEMD2 TUBGCP6 TUBB8B TUBGCP3 TUBGCP4 ESPL1 RBX1 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 PPP1CB NCAPD2 HDAC1 CDC7 LPIN1 LPIN2 LPIN3 PPP2R2A HSP90AB1 FBXO5 DYRK1A DHFR TK1 TYMS PPP2R3B GINS1 GINS2 CDC45 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 ABL1 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT LBR STAG1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 BIRC5 CHMP4A KIF2C CHMP6 KIF2B CHMP7 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CHMP2B CLASP1 DYNC1I1 CHMP2A CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ GMNN TPX2 SPC24 MAD2L1 CENPS NUP37 CDT1 SPC25 FEN1 MCM10 DBF4 FBXL7 RPA4 PKMYT1 CCNH PRKACA CDK7 MNAT1 RBL2 H2AC19 RBL1 H2AC14 H2BC12L AKT2 MYC AKT3 AKT1 CSNK2A1 CSNK2A2 CSNK2B JAK2 LYN H4C9 AJUBA H2AC20 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope PKP4 FURIN PCSK6 CAPNS1 CAPN1 TCHH TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ LIPN LIPM PRSS8 LIPK TGM5 DSP RPTN CELA2A SPINK6 SPINK5 DSG1 KAZN PKP1 LCE1E DSG2 LCE1F DSG3 LCE1C LCE1D LCE2B LCE2C LCE2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 FLG SPRR2E SPRR2F SPRR3 SPRR2G PERP CSTA KLK5 EVPL PPL KLK8 LCE2D LCE3C LCE3D LCE3A LCE3B LELP1 PI3 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B JUP KLK13 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function EZH2 FURIN H2AX PCSK6 ANK3 MDM2 H3-3B H3C8 MTBP CSNK2A3 H2AJ SRC CTNND1 CDH1 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RB1 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 MAPK3 FOXQ1 H2AB1 TLE1 ZBTB33 POMT2 CTSL H2AC8 H2AC6 PKM H2AC7 DNM2 MYCN TMEM258 POMT1 SEC11A KLF9 MCRIP1 SEC11C FOXJ2 STRAP FOXP2 OST4 SP1 OSTC STT3A ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 SPCS3 H2BC13 SPCS2 H2BC14 SPCS1 H2BC15 DAD1 HDAC2 H2BC11 JUP SIRT1 TCF3 PSMD8 RBBP4 CANX PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 PSMD1 H2AZ2 KMT5A TGIF2 KLF4 TNRC6C PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 PSMA7 TWIST2 TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC ARHGAP32 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 KDM1A CTNNA1 H4C9 SNAI1 VCL MOV10 AGO3 AGO4 H2AC20 AGO1 ZNF217 AGO2 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation EZH2 H2AX PAX6 ASH2L JUN H3-3B H3C8 H2AJ KMT2D H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 KDM6A H2BC1 POLR2A POLR2B POLR2C H2AB1 POLR2D POLR2E RXRA POLR2F RARG POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 RARA POLR2J POLR2K POLR2L CNOT6 KMT2C EGR2 HOXA2 HDAC3 CNOT9 RARB H2AC19 H2AC14 H2BC12L PAXIP1 DPY30 H2BC26 H2BC21 WDR5 EP300 EED H2BC17 HOXB4 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP CTCF NCOA6 PCGF2 PAGR1 H2BC11 HOXA3 HOXA1 PKNOX1 HOXA4 NCOR1 NCOA3 PIAS2 HOXB3 H4C9 HOXB2 RBBP4 HOXB1 RBBP5 YY1 AJUBA HOXD1 HOXC4 RBBP7 PBX1 MEIS1 H2AZ2 MAFB H2AC20 HOXD4 HOXD3 ZNF335 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization ACBD5 UBE2D1 SLC25A4 SLC25A6 SERP1 PMPCB PMPCA VDAC1 VAMP2 STX1A UBE2D2 GNPAT OTC TOMM70 USP9X TOMM20 TOMM22 HMOX1 CHCHD4 CHCHD5 CHCHD2 CHCHD7 CMC4 CMC2 SLC25A17 PAM16 COX19 COX17 PEX11B TIMM50 BAG6 PITRM1 LDHD GRPEL2 DNAJC19 HSCB BCS1L COA4 FIS1 UBE2D3 CHCHD10 TIMM44 CS EMD TIMM10B PXMP2 PXMP4 ACO2 TIMM17A CYC1 TIMM17B GET1 GET3 FXN COA6 CAT GET4 CAMLG TIMM23 TIMM22 TIMM21 NDUFB8 TOMM40 APP SLC25A12 TAFAZZIN TIMM9 UBA52 TIMM13 SLC25A13 TIMM10 HMGCL ATAD1 PEX16 UBL4A TIMM8B TIMM8A STX5 IDH3G PEX2 SGTA GDAP1 GFER VAPA ATP5MC1 TOMM7 TOMM5 TOMM6 ACOT8 UBB ATP5F1A CHCHD3 EHHADH HSD17B4 SAMM50 ACAA1 UBC ATP5F1B PECR DECR2 PEX10 ZFAND6 ABCD1 RPS27A PEX12 SLC27A2 IDE PEX13 ACOT4 CROT PEX14 PEX26 SCP2 NUDT19 MPV17 HSPA9 GSTK1 PHYH ECH1 MTX1 PIPOX ABCD2 ABCD3 PEX1 MTX2 BAAT PEX7 ACOX2 PEX3 ACOX1 PEX6 AGPS ACOT2 SEC61G ACOX3 SEC61B AGXT PAOX DDO HACL1 HAO1 HAO2 IDH1 NOS2 EPHX2 TYSND1 LONP2 DHRS4 NUDT7 OTOF AMACR DAO CRAT COQ2 GRPEL1 PRNP HSPD1 PEX19 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP83 CEP89 CEP57 CLASP1 YWHAE C2CD3 CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CDK1 B9D2 CEP290 NINL CC2D2A RAB8A OFD1 CPAP IQCB1 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 TMEM216 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 CEP152 CCP110 CEP250 CSNK1E SCLT1 CEP97 RAB11A CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D CEP162 TUBA1A B9D1 RPGRIP1L CEP41 CEP43 YWHAG FBF1 TTBK2 CEP70 NPHP1 CEP72 DYNLL1 CEP192 NPHP4 HSP90AA1 CKAP5 MARK4 CEP76 CEP78 PLK4 MAPRE1 ODF2 RAB3IP TUBB4B PAFAH1B1 TUBB4A DYNC1I2 AHI1 MKS1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 CYP2U1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity SMAD7 TRIM33 UBA52 UBE2D1 NCOR2 PPM1A RNF111 UBB UBC RPS27A USP9X SKI NEDD4L HDAC1 ATP1B4 MAPK1 WWTR1 PARP1 NCOR1 UBE2D3 MAPK3 SNW1 SKIL SMAD2 SMAD4 TGIF1 SMAD3 SMURF2 TGIF2 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition FBXO5 PLK1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes GSK3A PLA2G4B DNAJB11 LMNA SULT1A3 HYOU1 EXTL2 PREB EXTL3 GOSR2 ADD1 FKBP14 MYDGF TATDN2 CUL7 SERP1 SEC31A GFPT1 TSPYL2 DDX11 WIPI1 PDIA6 PDIA5 ATP6V0D1 SYVN1 PPP2R5B CTDSP2 KDELR3 SHC1 DCTN1 CXXC1 EXTL1 SSR1 ARFGAP1 DNAJB9 ZBTB17 KLHDC3 DNAJC3 WFS1 EDEM1 YIF1A TLN1 SRPRA ACADVL SRPRB TPP1 HDGF MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal MGMT LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation FCN3 MASP1 MBL2 COLEC11 COLEC10 FCN1 FCN2 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation JAK1 MAPK1 MAP2K2 IL6R JAK2 PTPN11 IL6 TYK2 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGF NGFR DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE MTRR MTR SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SLC24A4 CALM1 SLC24A2 SLC24A5 SLC24A3 SRI BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism MCCC2 SLC25A44 MCCC1 BCAT2 GLYAT PPM1K AUH IVD HIBCH ECHS1 HSD17B10 ACAT1 BCKDK BCKDHA DBT BCKDHB DLD ACAD8 HIBADH ACADSB ALDH6A1 CRAT BCAT1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 GNA14 PLA2G4A GNGT1 GNA15 GNA11 GNAQ P2RY1 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 MAPK14 GNB4 GNB3 GNB5 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis ST3GAL1 CHST5 ST3GAL2 ST3GAL3 CHST2 OGN CHST3 OMD B4GALT2 B4GALT3 B4GALT1 SLC35D2 B3GNT3 FMOD ST3GAL6 B4GAT1 B4GALT6 KERA B4GALT4 B4GALT5 CHST6 PRELP ACAN B3GNT7 B3GNT4 LUM CHST1 B3GNT2 ST3GAL4 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin MAOA ALDH2 SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy ATM PRKAG1 HSF1 PRKAG2 TOMM40 DYNC1I1 UBA52 DYNC1H1 PRKAG3 MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN UBC RPS27A MAP1LC3A FUNDC1 USP30 ATG9A VDAC3 ATG12 VDAC2 PEX5 ATG5 NBR1 VDAC1 UBE2D2 SQSTM1 PLIN3 ULK1 HSPA8 TBK1 VCP UBE2V1 DYNC1LI1 DYNC1LI2 PCNT PRKAB2 IFT88 TOMM70 CSNK2A1 CSNK2A2 TOMM20 UBE2L3 PRKAB1 TOMM22 CSNK2B UBE2N ARL13B EPAS1 MTERF3 DYNLL1 CETN1 PARK7 HSP90AA1 PRKAA2 DYNLL2 HDAC6 UBE2D3 PLIN2 CFTR PRKN DYNC1I2 PINK1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification SERPINA1 PPP6C TFG PPP6R1 PPP6R3 TMED2 CTSC TRAPPC2L LMAN1L MAGT1 F5 F8 TRAPPC6A TBC1D20 USP34 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 B3GNT3 LMAN2 CD59 SEC31B SEC31A DERL1 ANKRD28 DERL2 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 SEC16A TRAPPC10 OS9 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 SUZ12 H2BC9 CNIH3 H2BC8 FOLR1 NEDD8 H2BC5 BET1 CAND1 H2BC3 H2BC1 TUSC3 CP TF H2AC8 H2AC6 H2AC7 TMEM258 RNF139 UGGT2 VCP UGGT1 MARCHF6 EDEM3 SEL1L AMFR RNF103 TRIM13 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 DBT H2BC26 H2BC21 WDR5 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 COL7A1 RNF5 RBBP5 RBBP7 DCAF13 PCSK9 ELOB ELOC APOA2 APOA5 CD109 TAF10 RAB27B CALU GPIHBP1 ACTB QSOX1 DCAF7 ALB P4HB AHSG TUBB6 ADRB2 TUBB3 TUBB1 FBXO4 SPP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 APLP2 TP53 SCG3 SDC2 FBXL3 FBXL5 MMRN1 TUBA1C XRCC4 TUBA1B TUBA1A ST3GAL6 BAP1 B4GALNT2 UBXN1 TUBB2B UCHL1 TUBB2A SENP8 UCHL3 B4GAT1 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A B3GNT7 NUP205 B3GNT4 POM121 NUP188 B3GNT2 AAAS POM121C NUP42 NUP62 TPR NUP88 RAE1 SUDS3 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 GPC3 NUP50 NUP35 SLC17A5 GOLGB1 NUP54 ALG11 PDIA6 RPL8 KDELR3 DCTN1 FUT3 WFS1 EDEM1 USP10 MANEA RPS6 B4GALT2 B4GALT3 B4GALT1 HK1 TGFB1 EIF2AK2 OTULIN USP17L2 RCE1 RPL27A CALR B4GALT6 RPS23 B4GALT4 B4GALT5 ST6GALNAC6 PARP1 DNAJC3 CANX RPS2 CDC73 RNF152 ALG14 SHPRH ALG13 HLA-B PEX2 RNF40 RNF144A SKIC8 SELENOS WAC CTR9 TRAF3 RTF1 IKBKE TMEM129 HLTF LEO1 PEX10 PEX12 PEX13 PEX14 VNN1 PAF1 RNF181 VNN2 PROS1 ATXN3L MTA1 JOSD2 JOSD1 TOPORS TNFAIP3 GAS6 LY6E OTUD7B USP21 USP4 CYLD MGAT3 GALNT1 RAB27A U2AF2 TDG TTLL10 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 ANO8 AGBL3 TTLL1 AGBL2 GALNT11 TTLL13 GALNT14 TTLL11 GALNT13 TTLL12 GALNT16 TTLL9 GALNT15 TTLL8 LAMB2 GALNT18 GALNT17 GALNT10 FN1 GALNT9 GALNT8 LAMB1 B3GNT9 LAMC1 QTGAL B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 HLA-A GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT PSMD9 GALNTL5 RAB2A PSMD4 GALNTL6 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 FOXL2 PSMD10 PSMB11 HIC1 SP3 POMP PSMB10 PSMA8 VDAC3 PSMF1 VDAC2 PSMB8 PSMB9 PSMG3 PSMG4 PSMG1 VDAC1 PSMG2 UBE2D2 CDC34 CDH2 RHOA BMP4 TOMM20 UBE2N TAB1 PARK7 RAB10 RAB14 RAB13 CFTR TRAF6 ARFGAP3 AXIN2 RAB7A MGAT5B CSF1 LMAN1 STX5 YKT6 KTN1 MITF USP30 PGAP1 HDAC1 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 RHOT1 B3GALNT2 FUCA1 LYPD6B PIGS PIGU PIGT PIGO PROC PIGN PIGP TNC PIGZ PIGW PIGV PIGY PIGX GMPPB PMM1 CHST8 IFIH1 CRPPA RNF135 GMPPA PMM2 PIGC TRIM25 CGA PIGB MPI PIGA PTRH2 PIGK PIGM FBN1 PIGL MAVS PIGG PIGF RIGI DAG1 ARF5 PIGH ARCN1 ETFBKMT RAB5B LY6K RAB5C POFUT4 DPAGT1 POFUT2 ALG8 POFUT3 ALG9 RAB5A LY6D ALG6 LY6H ALG2 ATXN7 ALG3 SPRN ALG12 ETFB ALG1 FCGR3B MPDU1 SPACA4 RFT1 MDGA2 RECK MDGA1 KDELR2 GPS1 NRN1 ART3 ART4 SNX3 NTNG1 NTNG2 CUL2 BST1 GPAA1 OTUD7A MIA2 RNF20 RAB22A CD52 KIN USP33 STAMBPL1 NDUFAB1 ENGASE COPS4 ETF1 OTUD5 COPS2 RXYLT1 PRND EMID1 VCPIP1 CNTN5 HNRNPC UBE2T ST6GALNAC1 ALPL CNTN3 CMAS NANP CNTN4 ALPG FPGT PGM3 NGLY1 MYSM1 GNPNAT1 NANS VCPKMT MMRN2 GFUS NUDT14 OTUB1 ST6GAL2 OTUB2 TEX101 SLC35C1 ALG5 GOSR1 FURIN RAB40A RENBP DHDDS RAB40B RAB40C DPM1 TNIP1 DPM2 TGFBR1 TNIP3 DPM3 TGFBR2 ST6GALNAC5 GCSH USP17L4 GNE UAP1 USP17L5 USP17L8 NPL FUOM RNF128 NEU2 ALG10B NEU3 GPLD1 NEU4 LIPT2 LIPT1 DHRSX CHST10 RRAGA GMDS AMDHD2 GP2 NEU1 TADA2B ST8SIA4 ASGR1 ST8SIA5 PRSS21 ST3GAL5 ASGR2 ST8SIA6 COPZ2 CTSA COPZ1 WDR20 NUS1 METTL21A SLC35A1 ST8SIA1 USP17L3 ST8SIA2 USP17L1 GFPT2 PRSS41 ST8SIA3 EEF1AKMT2 SRD5A3 EEF1AKMT1 GFPT1 RAB3B DOLK RAB3C NAGK RAB3D RAB44 FCSK RAB41 DOLPP1 RAB42 LARGE2 VGF TECTA TECTB RAB2B DCAF8 USP5 DCAF5 USP3 DCAF4 RAB30 DCAF6 RAB36 WSB2 RAB37 APC SQSTM1 RAB34 OBSL1 FKBP8 DCUN1D5 STAMBP DCUN1D3 RAB4B DCUN1D4 PLET1 DCUN1D1 ARF1 CPM DCUN1D2 COMMD8 CTSZ PSCA COMMD9 RTN4RL2 BET1L PUM2 HIF3A PTP4A2 DDA1 MVD METTL22 RTN4RL1 ANKRD9 SEC23A COMMD2 RAB20 COMMD3 RAB25 POMT2 COMMD1 RAB26 SAR1B COMMD6 SEMA5A RAB23 COMMD7 RAB24 GALNT12 HSPA8 SPON2 COMMD4 RAB29 COMMD5 SEMA5B EEF2KMT SPSB3 SPON1 FKTN CCDC8 THSD7B SLC35A4 POMT1 CUL9 FKRP ADAMTS4 RAB15 UBD NAE1 ADAMTSL1 RAB19 SOCS6 MBTPS1 RAB17 SEC24B WDTC1 ADAMTS5 FOLR2 SOCS5 SEC24A C1GALT1C1 NFU1 CCDC22 ADAMTS2 USP17L30 COMMD10 ADAMTS3 YOD1 ADAMTSL5 TULP4 UMOD ADAMTSL4 DCAF16 LIAS MAT2B ADAMTS1 DCAF17 OTOA FEM1C ADAMTSL3 MLEC ADAMTSL2 DCAF10 ZRANB1 MUC12 DCAF11 RAET1G FEM1A MUC13 RAET1L FEM1B SEC24D THSD7A TMED3 SEC24C MUC15 TMED7 NEURL2 ERCC8 ADAMTS8 TMED9 LARGE1 IZUMO1R ADAMTS9 CEACAM7 ADAMTS6 NRN1L ADAMTS7 CEACAM5 SBSPON USP17L21 MUCL1 USP17L20 USP17L22 POMGNT1 MUC3A LY6G6C MUC5AC LY6G6D MUC3B USP17L15 ADAMTS20 USP17L18 B3GLCT UBE2L3 USP17L17 CFP USP17L19 FGF23 LSAMP THBS2 ADAMTS12 USP17L10 THSD1 USP17L12 THSD4 USP17L11 ADAMTS10 USP17L13 ADAMTS16 COPG2 ADAMTS15 COPG1 ALG10 MUC1 ADAMTS14 COPB2 ADAMTS13 COPA TRAF2 NTM MUC2 ADAMTS19 COPB1 ADAMTS18 MAN2A2 ADAMTS17 TMEM115 ULBP2 MUC7 COPE MUC4 USP37 MUC6 GALNT3 USP47 MUC16 USP48 MUC17 USP49 C1GALT1 USP42 BIRC2 MUC19 USP44 BIRC3 SSPOP PLAUR PRKN MUC5B POMGNT2 MUC20 USP16 MUC21 USP12 LRR1 RIPK1 ABRAXAS2 CCNF USP19 KEAP1 OPCML USP24 USP25 USP26 NEGR1 USP20 USP22 USP28 HERC2 XPNPEP2 POMK FBXO7 OGT FBXO9 WSB1 DLAT FBXO2 RNF123 UBE2J2 SIAH2 FBXL8 FBXL4 FBXL7 TRIM4 SERPINC1 LRRC41 GAN MFGE8 KLHL2 WDR48 CST3 UBE2G1 KLHL3 UBE2B UBE2G2 CUL4A F2 DDB1 KLHL9 SPSB2 DTL SPSB1 RAD18 CUL4B KBTBD6 KLHL5 KBTBD8 SPSB4 FBXO27 FBXO21 UBE2Z FBXO22 ASPH FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 KNG1 FBXO11 KLHL41 KCTD7 KLHL42 UBE2V2 CUL7 CUL5 UBA6 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W IGFBP7 ARF3 DLST UBA3 CBX8 PHC2 UBA1 PHC1 UBE2K CBX4 UBE2M CBX2 AMER1 KDM8 STS PHC3 KBTBD13 OGFOD1 EIF5A ARSA UBE2Q2 JMJD4 DHPS IL6 FN3KRP MDM2 JMJD7 SUMF2 MDM4 SUMF1 BMI1 UBE2R2 JMJD6 TPST2 F7 TPST1 RING1 F9 ASB13 ASB14 RCCD1 ASB11 EIF5A2 PROZ CCNA2 ASB12 DNAJC24 ARSL CCNA1 RNF7 DPH1 ARSJ ASB17 DPH2 ARSK ASB18 RNF2 FBXL22 DPH3 ARSH ASB15 ARSI FBXL21P ASB16 DPH5 ARSF FBXL20 DPH6 ARSG DPH7 ARSD CDKN2A ZC3H15 ASB10 RWDD1 VHL FN3K ICMT F10 DOHH FBXL19 RIOX1 FBXL18 GGCX FBXL15 RIOX2 FBXL16 FBXL13 DRG1 FBXL14 DRG2 FBXL12 ASB8 ASB9 ASB6 AREG ASB7 FSTL1 CHRDL1 ASB4 EEF1A1 ASB5 ASB2 ASB3 EEF2 ASB1 ADAM10 CTBP1 C3 C4A ARFGAP1 ALPI CKAP4 H2BC18 DNMT3B COP1 BECN1 DNMT3A DNMT1 IDE IL33 POLB ST6GALNAC2 PRKCSH FUT8 GANAB MAN2A1 MGAT5 CISH ST3GAL4 MGAT1 MGAT2 ST3GAL1 SOCS2 ST3GAL2 ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C MGAT4A MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 ARFGAP2 MDC1 KDELR1 NLRP3 UFD1 TRIM27 USP13 TNKS TNKS2 RNF146 GATA3 OTUD3 MAN1A2 MAN1C1 MAN1A1 HNRNPK NPLOC4 RAB32 RAB31 RAB38 ACTL6A NSF DDB2 RAB21 GRIA1 CHML RAB39A RAB39B RAB12 RAB18 BGLAP SPP1 USP9X TOMM70 TADA3 PDIA3 PNPLA2 UBE2D3 PSMD8 PSMD6 YY1 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 RIPK2 DCTN5 BCL10 PSMA7 DCTN4 RELA PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SMC5 RPS27A SMC6 DDX17 ADRM1 NSMCE3 NSMCE2 SEM1 NSMCE1 NFKBIA MRTFA PSMC5 EID3 PSMC6 PSMC3 ZBED1 PSMC4 UBA2 PSMC1 SAE1 PSMC2 FOXO4 TOP2A USP14 TOP2B ZNF131 ATXN3 SENP5 SOCS3 SENP2 NOD1 SAFB PIAS4 NOD2 SENP1 NSMCE4A HDAC4 PIAS3 TOP1 USP18 SP100 THRB UHRF2 UBE2I SATB1 VDR CASP8AP2 NR1H2 RORA NOP58 NR3C1 TNIP2 RWDD3 MBD1 NR2C1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA FBXO32 BRCA1 CCP110 PTEN CSNK1D RABGGTB RABGGTA BLM UBXN7 PCNA WRN MUL1 DPP3 BARD1 RPA1 PALB2 ARF4 CETN2 UBE2C UBE2E1 UBE2D1 TRIM28 ACTR1A UBE2S CDK1 STAM RAB8A HGS L3MBTL2 TGFA STAM2 APOE SATB2 DCTN2 DCTN3 NPM1 GBF1 RAB11A NRIP1 EP300 APOB PPARGC1A TFAP2B NCOA1 TFAP2C NCOA2 CREBBP APOA1 CHD3 NFE2L2 RAB43 COG8 COG7 COG6 AURKA COG5 INS COG4 CALM1 COG3 COG2 COG1 APP NAPA NAPB CDC25A NAPG GOLGA2 TGOLN2 RAB6A RAB6B TUBB8 RAB9A TUBB8B RAB9B RBX1 RAB8B RAB4A RAB33A RAB33B RAB11B RAB35 RAB7B CHM ING2 NCOR2 KAT2B KAT2A ZNF350 CD55 SYVN1 PCGF2 DDX5 HIPK2 KDM1B ANK2 CUL3 ANK3 ANK1 MEN1 IGFBP1 KBTBD7 USP7 SPTBN4 SPTBN5 SPTA1 IGFBP3 USP2 SPTBN1 SPTBN2 VCAN GLB1 ARSB CDKN1A SPTAN1 CAMKMT SPTB SKP2 DAXX NUP107 SMC3 CDC20 LHB DYNC1LI1 DYNC1LI2 PENK CDCA8 NUP160 NUP85 RAD21 SIN3A RAB3A STAG1 STAG2 SEC13 NUP133 HDAC2 DYNLL1 SMC1A RUVBL1 RANGAP1 NFRKB DYNLL2 ACTR5 INCENP HDAC7 RAD23A BIRC5 ACTR8 RAD23B INO80C INO80B INO80E DYNC1I2 INO80D COPS7B AURKB COPS7A XPC PML TFPT MCRS1 NUP43 INO80 COPS3 COPS6 DYNC1I1 COPS8 RANBP2 DYNC1H1 NUP37 KCTD6 CAPZB SMAD2 SMAD1 SMAD4 SMAD3 BRCC3 CBX5 SMURF2 CAPZA1 CLSPN TP53BP1 CAPZA2 BABAM1 BABAM2 TIMP1 UIMC1 SMAD7 RNF168 ABRAXAS1 DMP1 LGALS1 EVA1A RAD52 CCN1 CHGB IGFBP5 IGFBP4 SHISA5 H2AC17 MXRA8 H2AC12 AXIN1 SPARCL1 FDX1 PRMT3 H2AC1 SCG2 USP15 H2AC19 H2AC25 STC2 H2AC14 H2AC21 AMELX AMBN MYC TMEM132A LTBP1 FUCA2 THBS1 BPIFB2 HRC MELTF HSP90B1 SERPINA10 UCHL5 MIA3 MSLN PRSS23 USP8 BMP15 MEPE RCN1 ENAM RPN2 EPAS1 AMTN FAM20C RPN1 VWA1 ARRB1 FAM20A MATN3 ARRB2 ITIH2 HIF1A AFP FSTL3 APOL1 SERPIND1 FGA GOLM1 NUCB1 FGG NOTUM H4C9 PRKDC TRRAP H2AC20 MCFD2 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MT-CYB MT-ND6 MT-ND4L MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 MTRF1 GFM2 MRRF MTRF1L MT-ATP6 MT-ATP8 MT-CO1 MT-CO2 MRPS17 MT-CO3 MRPS15 MRPS16 MRPS14 MRPS11 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA8 IFIH1 IFNAR1 TRIM25 IFNA21 IRF3 IFNA14 IFNA16 IFNA17 MAVS UBA52 IFNA10 RIGI ELOB ELOC TYK2 JAK1 STAT2 UBB UBC EIF2AK2 RPS27A CUL5 EP300 RBX1 IFNB1 CREBBP IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis PLD4 AGPAT5 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 PLA2G4B HADHB PLA2G2A ABHD3 HADHA DDHD2 PCTP DDHD1 GNPAT CEPT1 MFSD2A LPCAT4 PLA2G10 PCYT1B GPD1 CHKB PCYT1A GPD1L PLA2R1 CHKA STARD10 PHOSPHO1 PEMT CHPT1 GPAM ACHE BCHE CHAT PNPLA2 ALPI PITPNB TAFAZZIN AWAT2 PLD1 LPGAT1 CPNE7 CPNE6 CPNE1 CPNE3 PCYT2 PISD PLA2G15 SLC44A5 PGP PLA1A ABHD4 SLC44A3 PGS1 SLC44A4 PTPMT1 SLC44A1 OSBPL8 SLC44A2 OSBPL5 DGAT2L6 CRLS1 CDS2 OSBPL10 PLAAT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 GPAT2 DGAT2 PTDSS2 SELENOI PTDSS1 MBOAT1 DGAT1 ETNPPL ETNK2 ETNK1 PNPLA3 GPD2 MBOAT7 LPIN1 STARD7 LPIN2 MGLL LPIN3 PLA2G3 PLA2G6 PLB1 PLA2G4F CDS1 TMEM86B PLA2G4E PITPNM1 PITPNM3 PNPLA8 PLA2G4C PITPNM2 AGK CDIPT MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 PLA2G4A CSNK2A1 CSNK2A2 PLD3 CSNK2B PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK10 KCNJ2 KCNK13 KCNK16 KCNJ4 KCNK17 KCNK18 KCNK5 KCNK12 KCNJ14 KCNK15 KCNK6 KCNJ12 KCNK2 KCNK7 KCNK1 KCNK3 KCNK4 KCNK9 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks ATM MRE11 RAD50 KAT5 KPNA2 NBN INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic COG7 GOSR1 COG6 COG5 COG4 COG3 COG2 COG1 RAB39A NAPA NAPB STX16 VPS45 NAPG STX5 YKT6 GOSR2 VTI1A STX6 TRIP11 RIC1 MAN1A2 RGP1 MAN1C1 MAN1A1 RAB41 RAB30 RAB36 MAN2A2 ARF1 GOLIM4 CYTH3 CUX1 RAB33B CYTH2 BET1L GOLGA5 CYTH4 SNAP29 CYTH1 NSF ALPP MAN2A1 COG8 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases ASCC2 ASCC3 ALKBH2 ALKBH3 FTO ALKBH5 ASCC1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling EREG BTC PIK3CA PIK3R1 NRG1 NRG2 HBEGF NRG3 NRG4 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR PDHX PDHA2 PDHA1 DLD DLAT PDHB SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism SFTA3 DMBT1 LMCD1 NAPSA CCDC59 SFTPC ADA2 PGA3 SFTPB PGA5 ABCA3 PGA4 ADGRF5 SFTPA1 SFTPA2 ADRA2C ADRA2A GATA6 TTF1 SLC34A2 ADORA2A P2RY2 SLC34A1 ADORA2B CTSH CSF2RB CSF2RA SFTPD ZDHHC2 CKAP4 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins ISCU CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import PEX26 ACBD5 ABCD2 SLC25A17 ABCD3 ATAD1 PEX11B PEX16 PEX3 PEX2 GDAP1 FIS1 PXMP2 PEX19 PXMP4 PEX12 ABCD1 PEX13 PEX14 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling PPP1CC SHOC2 ARAF PPP1CB RAF1 BRAF YWHAB MRAS DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis CSPG5 CSPG4 NCAN BGN UST DSE DCN BCAN VCAN CHST15 DSEL CHST14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 HBB IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 APOA1 IGLC2 HBA2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 LRP1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 ALB HP HPR HPX IGHA1 IGHA2 AMBP JCHAIN CD163 APOL1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis GSDMD GZMB NMT1 YWHAE CYCS SFN BAX C1QBP GSDME BCL2L11 CASP7 TP53BP2 YWHAH YWHAZ MAPK8 BBC3 CDKN2A YWHAB E2F1 CASP3 MAPK1 STAT3 TFDP1 MAPK3 TFDP2 TP73 PMAIP1 BCL2 BCL2L1 TP53 AVEN DIABLO CARD8 UACA PPP1R13B BID AKT2 AKT3 BAD CASP9 AKT1 APAF1 CASP8 YWHAG PPP3CC BMF TP63 DYNLL1 DYNLL2 APIP YWHAQ XIAP BAK1 PPP3R1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF4EBP1 EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 EIF5 RPS13 EIF5B RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 EIF2B5 RPL15 EIF2B4 RPS2 EIF2B3 RPL18 EIF2S3 RPL17 EIF2B2 EIF2B1 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis NFKBIA MAPKAP1 RICTOR RPTOR PIK3C3 NFKBIB BECN1 RETREG1 DAXX TAOK1 PRR5 PIK3R4 ATG14 RIPK1 MTOR MLST8 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic TMED2 ARF4 NAPA NAPB CENPE SEC22B NAPG RAB1A TMED10 COPZ2 COPZ1 RAB1B KIF4B KIF4A KIF20A KDELR3 KLC1 KLC4 KLC3 KLC2 KIF11 KIF15 ARF1 KIF23 KIF22 NSF KIF26A ZW10 ARF5 KIF5C ARCN1 KIF5B KIF5A GBF1 TMED3 KIFAP3 TMED7 KIF28P TMED9 KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KIF25 KDELR2 KIF18A KIF6 KIF27 RINT1 ARFGAP2 KIF9 KIFC2 KIF16B KIFC1 KIF20B KIF3B KDELR1 NBAS KIF3A COPG2 STX18 COPG1 BNIP1 COPB2 SURF4 COPA KIF18B KIF26B COPB1 KIF3C ARFGAP1 COPE KIF2A KIF2C KIF2B RACGAP1 ARFGAP3 ARF3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins SCN11A SCN9A NRCAM SCN1B SCN1A ANK2 ANK3 ANK1 SCN10A SCN8A KCNQ2 KCNQ3 SPTBN4 SPTBN5 SPTA1 SCN3B SCN3A SPTBN1 SPTBN2 L1CAM SCN2A SCN2B SCN5A SPTAN1 SPTB SCN4A SCN4B SCN7A NFASC MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL TUBGCP2 TUBGCP5 TUBGCP6 OFD1 TUBGCP3 CPAP TUBGCP4 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK6 KCNK2 KCNK7 KCNK10 KCNK1 KCNK3 KCNK4 KCNK9 KCNK13 KCNK16 KCNK17 KCNK18 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair RAD1 ATM RAD9B ATR H2AX RAD9A LIG1 CCNA2 CCNA1 RNF4 H2BC9 H3-4 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CDK2 SIRT6 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PARP1 PARP2 ERCC4 HERC2 ERCC1 UBA52 UBB UBC RPS27A FEN1 SEM1 PIAS4 UBE2I XRCC1 LIG3 PPP4R2 TIPIN TIMELESS BRCC3 PPP4C CLSPN TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 MUS81 RNF8 MRE11 NSD2 BRCA1 RAD52 BRCA2 EME1 KAT5 EXO1 EME2 FIRRM CHEK1 NBN TOPBP1 POLK POLE POLH GEN1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 UBE2V2 TOP3A HUS1 SPIDR RAD51B RAD51D RAD51C DNA2 POLQ MDC1 RHNO1 BLM RTEL1 PCNA RAD51AP1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 H4C9 XRCC2 XRCC3 RPA1 RPA2 PALB2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism PCCB MMUT MCEE PCCA MMAA DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation MET HGF MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins PPP1CC CSNK2B FURIN SPCS3 PPP1CB SPCS2 SPCS1 SEC11A SEC11C PPP1CA KPNB1 XPO1 CSNK2A1 CSNK2A2 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 CDC20 FBXO5 CDK1 PLK1 FZR1 CCNB1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery POLR2I POLR2J POLR2K POLR2L CCNK CCNT2 ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production TNFRSF1A SMPD3 SMPD2 RACK1 TNF NSMAF ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism GOT2 FOLH1 FOLH1B GADL1 ASPG NAALAD2 NAT8L ASNS SLC25A12 ASPA SLC25A13 GOT1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription FURIN SMAD7 CDK8 CCNK CCNT2 CCNT1 CCNC UBA52 MEN1 SERPINE1 YBX1 SP1 JUNB RBL1 RNF111 COL1A2 UBB MYC UBC RPS27A EP300 CDK9 CDKN2B HDAC1 E2F4 MAPK1 WWTR1 E2F5 MAPK3 TFDP1 TFDP2 SMAD2 SMAD4 TGIF1 SMAD3 TGIF2 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation JAK1 CDK1 MAPK3 MAP2K1 IL6R JAK2 PTPN11 IL6 TYK2 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor CALM1 NRAS CAMK2B RASGRF2 CAMK2D ACTN2 RASGRF1 CAMK2A GRIN2B HRAS GRIN2D DLG1 GRIN1 DLG3 DLG4 DLG2 LRRC7 NEFL CAMK2G EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere ACD DNA2 BLM PCNA LIG1 POLD3 POLD4 WRN POLD1 POLD2 TINF2 RPA1 RPA2 TERF1 TERF2 RPA3 POT1 TERF2IP FEN1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation PCSK9 AP2A1 AP2S1 AP2A2 UBA52 CLTC CLTA NR1H3 AP2M1 MYLIP AP2B1 VLDLR NR1H2 UBB UBC RPS27A LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis CD3G RAC1 VAV1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 IGHG3 IGHG4 IGHG1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 WASF3 MYO10 MYO1C RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab HSP90AA1 CDC37 ERBIN ERBB2 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs ALOX5 PTGS2 CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP1A2 LTC4S CYP1A1 CYP2E1 ALOX15 GSTM4 EPHX2 ALOX12 HPGD LTA4H EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination LAMA2 ADGRG6 LAMB1 LAMC1 EGR2 DAG1 CYP51A1 HMGCR TEAD1 PMP22 MAG NAB1 NAB2 YAP1 POU3F1 POU3F2 UTRN SOX10 MBP HDAC2 ADGRV1 WWTR1 SMARCA4 PRX SREBF2 DRP2 SCD5 MPZ SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK PTPN6 MYCN CD274 IL2RG JAK3 DNMT1 PTPRZ1 MDK HDAC3 ALK IRS1 PRDM1 MYC SIN3A PIK3CB EP300 PIK3R2 HDAC1 PIK3R1 PIK3CA HDAC2 HIF1A STAT3 PLCG1 PTN ALKAL2 FRS2 ALKAL1 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 HMGA1 PSIP1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance H2AX MTA2 H3-3B TBP H3C8 H2AJ RRN3 ERCC6 H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 MAPK3 CCNH MBD2 H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 KAT2B MNAT1 KAT2A H2AC19 H2AC14 H2BC12L MBD3 H2BC26 H2BC21 TTF1 GATAD2B UBTF GATAD2A H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 EHMT2 POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling CHUK NFATC3 NFATC2 FBXW11 NFATC1 PSMA5 PSMA6 CALM1 PSMA3 UBE2M PSMA4 PSMA1 PSMA2 UBA52 CARD11 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2D2 AHCYL1 CDC34 PLCG2 UBE2V1 SYK PRKCD NFKB2 ITPR1 ITPR2 MAP3K14 PYCARD ITPR3 CLEC7A CARD9 RELB CASP8 UBE2N TAB3 PDPK1 TAB2 TAB1 IL1B PSMD8 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PPP3CA PSMD3 PPP3CB PSMD1 IKBKG BTRC MAP3K7 SKP1 PPP3R1 UBA3 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR HSP90AA1 GCHFR NOS3 CALM1 PTS SPR PRKG2 AKT1 GCH1 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity TNRC6A CALM1 TNRC6B PRKACA HTT NCOR2 CAMK2B CAMK2D HDAC3 CAMK2A SIN3A CAMK4 GPS2 CAMK2G LBR FOXG1 TBL1X HDAC1 HDAC2 NCOR1 HIPK2 TBL1XR1 MOV10 AGO3 AGO4 AURKB AGO1 AGO2 TNRC6C NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway CHUK ITCH UBE2V1 CASP2 RIPK2 CASP9 CARD9 AAMP CASP8 UBE2N TAB3 CASP4 TAB2 TAB1 IRAK1 CASP1 NOD1 NOD2 IRAK2 TNFAIP3 IKBKB BIRC2 TRAF6 BIRC3 CYLD MAPK14 IKBKG MAPK12 MAP3K7 MAP2K6 MAPK13 MAPK11 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling STAT4 JAK1 STAT5A STAT3 STAT5B IL21R IL21 IL2RG JAK3 STAT1 COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism MMUT MTRR MMAB MTR MMACHC MMADHC MMAA SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses POM121C NUP42 IFNAR1 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 TYK2 NUP50 JAK1 NUP35 NUP54 HLA-A B2M STAT2 ATG14 IFNB1 STAT1 TKFC SEC23A NUP107 SAR1B KPNA2 TBK1 IRF3 UBE2V1 SEC24B SEC24A NUP160 SEC24D SEC24C HLA-H HLA-C HLA-F NUP85 PIK3R4 HLA-G HLA-E ISG15 TOMM70 IL17RC IL17RA UBE2N TLR1 TAB3 TAB2 TAB1 IRAK1 TLR2 SEC13 NUP133 PIK3C3 CREBBP HSP90AA1 IKBKB TRAF6 IKBKG PTPN11 MAP3K7 CHUK PTPN6 NUP43 RANBP2 BECN1 HLA-B RIPK2 TRAF3 IKBKE NUP37 TRIM4 NOD1 NOD2 IRAK2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 LARP1 SIKE1 MAVS IFNA10 RIGI TLR8 TLR7 G3BP1 G3BP2 HSP90AB1 MASP1 MBL2 CNBP NLRP3 IRF7 SFTPD NLRP12 NUP205 POM121 IL17F NUP188 IL17A STING1 AAAS SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DOLK DOLPP1 DHDDS NUS1 MVD SRD5A3 DHRSX CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation NFATC3 NFATC2 NFATC1 ITPR1 CALM1 ITPR2 ITPR3 PPP3CA PPP3CB AHCYL1 PPP3R1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation MCM6 MCM2 H2AX ANAPC15 ANAPC16 KPNA1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 H3-3B CDC16 ANAPC4 ORC5 H3C8 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 H2AJ ORC3 ORC2 H3C15 FZR1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 CDC6 KPNB1 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 KPNA6 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 MCM10 PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PSMC1 RPA4 PSMC2 CDC7 POLE H2AC19 H2AC14 H2BC12L H4C9 RPA1 RPA2 CDC45 POLE4 MCM7 H2AC20 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGF9 FGF20 FGF23 FGF16 FGF18 FGFR3 FGF1 FGF2 FGF4 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 CXXC4 DVL3 CCDC88C CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli BAG5 HSPH1 EZH2 DNAJB6 BAG3 H2AX HSF1 BAG1 HSPA4 ST13 HSPA7 HSPA6 HSPA12A HSPA12B PREB H3-3B H3C8 CHAC1 FOS GOSR2 TCIRG1 H2AJ ATP6V1E1 ATP6V1E2 YAP1 ATP6V0B ATP6V1G1 SEC31A ATP6V0E1 ATP6V1G2 H3C15 NOS3 ATP6V1B2 ATP6V0D1 RICTOR ATP6V0C ATP6V0D2 ABCG2 ATP6V1B1 SUZ12 H2BC9 ATP6V1A H2BC8 H2BC5 STAT1 H2BC3 STAT3 ATP6V1H H2BC1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 H2AB1 H2AC8 H2AC6 H2AC7 VCP EPO CA9 HIGD1A PRR5 GSK3B PIK3CD PIK3CB H2BC26 H2BC21 MLST8 EED PDPK1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA H2BC11 PRKAA2 RBBP4 FYN RBBP7 PKN2 H2AZ2 MTOR TNRC6C TNRC6A TNRC6B CREB3L3 PRKACG PRKACB ELOB ELOC KDR PTK6 GJA1 ALB P4HB IDH1 TP53 TALDO1 HSPG2 GNAQ PECAM1 STIP1 GNA11 NUP205 POM121 NUP188 AAAS POM121C NUP42 SZT2 SAMTOR NUP62 TKT SEH1L TPR NPRL2 NPRL3 NUP88 RAE1 GCN1 WDR59 EIF2AK4 NUP214 NDC1 FLCN NUP210 MIOS EXTL2 NUP155 ITFG2 IMPACT HMGA1 NUP153 KPTN DEPDC5 NUP93 NUP50 WDR24 SH3BP4 NUP35 NUP54 FNIP1 FNIP2 KICS2 CASTOR1 EXTL3 CASTOR2 ADD1 FKBP14 HERPUD1 MYDGF PANX1 TATDN2 SERP1 CREB3L4 CREB3L1 RPL4 CREB3L2 RPL5 TSPYL2 RPL30 DDX11 RPL3 WIPI1 RPL32 PDIA6 RPL31 PDIA5 ERN1 RPL34 PGD CREB3 RPL10L RPL10A DCSTAMP RPL8 CTDSP2 KDELR3 RPL6 RPL7 ATF6B DCTN1 CEBPG RPS15 CXXC1 RPS14 EXTL1 RPS17 SSR1 RPS16 DNAJB9 RPL18A ZBTB17 RPS19 RPS18 KLHDC3 WFS1 RPL36AL EDEM1 RPL36 ASNS YIF1A RPL35 CREBRF RPL38 SRPRA SRPRB RPL37 TPP1 HDGF RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A DNAJC3 RPL37A EIF2AK1 ATF5 RPL10 TXN2 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 HSPA1A IKBKE HSPA5 ABCC1 GSK3A OMA1 PRKAR1A EIF2AK3 CACNG7 ATP7A TRPV4 STOML2 PHB2 YME1L1 UBE2D2 PLA2G4B ITGB1 MT2A MT1A MT1M MT1F MT1G MT1X MT1H MT4 MT1B MT3 MT1E DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS6KA1 HSPE1 FABP1 ID1 PPP2R2A PIEZO1 ITGAV ANXA2 PTK2 PRKAR2A GSTA1 HSP90AB1 CUL2 RPTOR FLT4 RRAGA RRAGC RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 GFPT1 LAMTOR3 LAMTOR5 CACNA1H SQSTM1 HIF3A MTF1 ACADVL HSPA8 MBTPS1 NFYA NFYB NFYC SP1 MBTPS2 IL1A KEAP1 CYCS TRIM21 HSPA9 PRKACA DEFA5 CAMK2B CAMK2D CAMK2A CAMK2G CUL7 EHMT2 EHMT1 ETS1 ETS2 P2RY2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 MAP2K4 TINF2 ERF MAPKAPK5 AJUBA TNIK ASF1A TXN EP400 IGFBP7 MAP2K7 NRF1 MAP2K6 DELE1 CBX8 HTRA2 CBX6 PHC2 DNAJA1 ACD DNAJA4 PHC1 LONP1 CBX4 CBX2 HMGA2 AMER1 H1-1 PHC3 H1-0 H1-3 H1-2 H1-5 H1-4 IL6 MDM2 MDM4 CXCL8 BMI1 CABIN1 VENTX KDM6B RING1 MINK1 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP CEBPB RNF2 HIRA MAPK9 MAPK8 MAPK7 UBN1 MAP4K4 CDKN2D CDKN2B CDKN2C CDKN2A IFNB1 VHL MAPK10 H3-4 EGF BCL2 PDGFA AREG BCL2L1 EEF1A1 NCF1 NCF2 NCF4 CYBB ARFGAP1 CYBA EIF2S3 EIF2S2 EIF2S1 MAP1LC3B FBXL17 SLC7A11 ADCY9 PRKAR1B PRKAR2B HYOU1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MT-CO1 NLRP3 UFD1 DDIT3 P2RX7 TXNIP MT-CO2 MT-CO3 DNAJB11 NPLOC4 HSPA1B BAG2 SIRT3 DNAJA2 SPP1 UBE2D3 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 SESN2 PSMD1 IKBKG BTRC SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SULT1A3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 CSRP1 PSMD13 SNCB DCTN6 PRKCI CUL1 DCTN5 PSMA7 DCTN4 RELA PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RORA NR3C1 ESR1 NR3C2 AR RXRA PGR PPARA MRE11 LMNA BRCA1 KAT5 NBN COX4I1 COX4I2 AQP8 NUDT2 ATF4 ARNT PRDX3 PRDX6 NOX5 UBXN7 GSTP1 NQO1 ITGA5 GSTA3 ERO1A SESN1 MUL1 DPP3 STAP2 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 GPX1 RPA1 GPX3 RPA2 GPX6 PTPN1 PALB2 GPX5 GPX8 GPX7 RAD50 BLVRB RPA3 BLVRA HM13 CCL2 ABCF2 TXNRD2 SOD3 ATM ATOX1 SOD1 ATR CCS ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ACTR1A ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CTNNB1 SHC1 MAPK1 MAPK3 COX7B CDH5 COX7C MAPK14 COX8A MAPK11 COX8C MAPKAPK3 MAPKAPK2 COX5B DCTN2 COX5A DCTN3 COX6C ATF2 VEGFA CRTC2 SLC46A1 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 LY96 COX6A1 COX6A2 HBB BACH1 NPAS2 G6PD HELZ2 RAI1 XPO1 PGRMC2 COX6B2 TGS1 COX6B1 NRIP1 HMOX1 EP300 ATF6 TBL1X APOB HIGD1C CLEC1B MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 APOA1 HBA2 NR1D1 SIRT1 HSPA1L NCOR1 TBL1XR1 CARM1 MAFK TLR4 BMAL1 CLOCK NFE2L2 HSPA2 CAT CALM1 YWHAE JUN SOD2 FOXO3 LMNB1 PRDX2 CAPNS1 CAPNS2 PRDX1 CAPN2 NOTCH1 RBX1 ADM GNGT1 GNGT2 RAMP2 CALCRL NCOR2 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 DCP2 NOX4 SYVN1 FKBP4 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 CUL3 IGFBP1 FKBP5 RB1 CDKN1A CDKN1B FZR1 E2F1 E2F2 E2F3 ABL1 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 NUP107 PPP2R1B PPP2R1A DYNC1LI1 CACNA2D1 DYNC1LI2 NUP160 NUP85 SIN3A GPX2 RPS27 CACNB1 CACNB2 CACNB3 SEC13 NUP133 PPP2R5B DYNLL1 DYNLL2 HDAC6 DYNC1I2 TXNRD1 PPP2CA NUP43 DYNC1I1 RANBP2 DYNC1H1 COX7A2L CITED2 NUP37 COXFA4 CAPZB COX7A2 COX7A1 LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP CAPZA1 CAPZA2 MMP14 PRKCD PPP1R15A H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 HSPD1 AKT1 HSP90B1 CSNK2A1 CSNK2A2 CSNK2B TRIB3 ATF3 ITGB3 EPAS1 MAPKAP1 PIK3R2 HIF1A GRB10 HSPB8 HIKESHI H4C9 CCAR2 HSBP1 DNAJC2 DNAJC7 TLN1 MOV10 CRYAB VCL AGO3 RPS19BP1 AGO4 HSPA4L H2AC20 HSPA14 AGO1 HSPA13 DNAJB1 BAG4 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency OTC VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 ELOB PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CUL5 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) SREBF1 TM7SF2 MSMO1 SREBF2 HSD17B7 NSDHL CYP51A1 DHCR24 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression GATA4 NKX2-5 TEAD1 HIPK1 TEAD2 KAT2B WWTR1 TEAD3 CCN2 HIPK2 TEAD4 NPPA TBX5 YAP1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKA PSMA5 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 RB1 PSMC1 PSMC2 FZR1 SKP2 CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 AURKB PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis IMPDH2 GART PAICS PFAS ATIC PPAT ADSL GMPS ADSS1 IMPDH1 ADSS2 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions CD209 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 XDH BTN1A1 BTN3A3 BTN3A2 BTNL2 PPL HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state PSMA5 PSMA6 ITCH PSMA3 PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 IFT52 PRKACB PSMD11 GLI1 PSMD14 KIF7 PSMD13 GPR161 CUL1 INTU TULP3 PSMA7 FUZ ADCY10 PSMB6 PSMB7 PSMB4 PSMB5 IFT57 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 OFD1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 IFT140 PSMC1 PSMC2 NUMB WDR35 ADCY9 PRKAR1B SMO GLI3 PRKAR2B GLI2 PRKACA ADCY4 ADCY3 IFT172 ADCY2 ADCY1 WDR19 ADCY8 ADCY7 ADCY6 PRKAR2A CSNK1A1 DYNC2H1 ADCY5 GSK3B PRKAR1A RPGRIP1L IFT88 KIF3A TTC21B PTCH1 SUFU PSMD8 PSMD6 PSMD7 PSMD2 IFT122 PSMD3 GNAS PSMD1 BTRC MKS1 SKP1 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways POM121C NUP42 NUP62 NUP43 TPR NUP88 GBP1 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 CPSF4 MLKL EIF2AK2 ISG15 NUP37 SEC13 NUP133 KPNA7 KPNA4 NUP205 KPNA5 POM121 NUP107 NUP188 PABPN1 KPNA2 AAAS KPNA3 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases NHERF4 GUCY2C TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CALM1 PRKACG PRKACB FLT4 CAPNS1 CAPNS2 CAPN2 PANX1 CTNNB1 KDR NOS3 RICTOR ADM GNGT1 GNGT2 CDH5 ADCY9 PRKAR1B PRKAR2B RAMP2 PIEZO1 PRKACA CALCRL MMP14 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GNAQ ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ADCY5 GNG2 PRR5 PECAM1 GNG5 GNG4 PIK3CD GNG7 PRKAR1A GNG8 PIK3CB AKT1 MLST8 PDPK1 MAPKAP1 PIK3R2 PIK3CA P2RY2 GNA11 GNG12 GNG11 GNG13 FYN GNB2 TLN1 VCL GNB1 GNAS PKN2 GNB4 GNB3 TRPV4 GNB5 MTOR RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHCG RHBG RHAG B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2AX H3-3B TBP H3C8 MYBBP1A H2AJ ERCC6 H3C15 SF3B1 H2BC9 H2BC8 H2BC5 H2BC3 ACTB H2BC1 H2AB1 POLR2E POLR2F H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L KAT2B KAT2A H2AC19 H2AC14 H2BC12L GSK3B SMARCA5 H2BC26 H2BC21 BAZ1B EP300 DEK H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 H2AZ2 H2AC20 DDX21 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells DPPA4 ZIC3 SALL4 EPAS1 NANOG EPHA1 POU5F1 STAT3 SALL1 HIF3A SMAD2 FOXD3 PRDM14 SOX2 PBX1 LIN28A SMAD4 NR5A1 ZSCAN10 CRIPTO FGF2 KLF4 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression NOTCH1 EP300 RELA MAFK MYC NFE2L2 CREBBP NFKB1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants NOTCH1 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 ADAM17 NEURL1 MIB2 UBB UBC RPS27A DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors MCCC2 MCCC1 GSTO2 DHFR2 PRSS1 NADSYN1 FLAD1 CTRB2 CTRB1 SLC5A8 BTD MTHFD1 NOS3 MTHFD2 MTHFD2L SHMT1 HLCS SLC19A3 PNPO SLC19A1 SLC19A2 CBLIF MTHFR APOE MTHFS TCN1 CD320 MOCS2 MOCS3 QPRT THTPA SLC22A13 NMRK2 RFK NMRK1 CD38 VKORC1 MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 ACO1 NMNAT1 VKORC1L1 ALDH1L1 ALDH1L2 NUDT12 SLC25A51 UBIAD1 NADK SLC52A2 SLC52A3 SLC52A1 GPHN NADK2 NAPRT ACP5 AOX1 SLC46A1 SLC25A19 PDXK NAXE SLC25A32 NAXD APOB APOA1 LRP2 CLPS PNLIP CALM1 LRP1 LRP8 SHMT2 LDLRAP1 NAMPT CUBN AMN APOA2 BCO2 APOA4 BCO1 LPL LDLR GPIHBP1 APOC3 APOC2 IDH1 PTS SPR PDSS2 PDSS1 GCH1 STARD7 COQ9 COQ7 COQ6 COQ5 GCHFR PLB1 COQ4 HPDL COQ3 COQ2 COQ8B COQ8A APOM HSPG2 SDC4 SDC2 SDC3 AKR1B10 NT5E SDC1 BST1 DHFR GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 AGRN ACACB ACACA NNMT FOLR2 MTRR GSTO1 MTR ABCD4 SLC2A1 LMBRD1 LRP10 LRP12 TTPA AKR1C1 HSP90AA1 AKR1C4 TCN2 PC PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT TTR ABCC1 PARP6 PARP4 PRSS3 PARP16 PARP9 PARP14 PARP8 PARP10 SLC2A3 PRKG2 AKR1C3 RDH11 AKT1 LRAT PCCA MMAA PCCB MMUT RBP4 RBP2 SLC23A2 MMAB RBP1 CYB5A MMACHC MMADHC RETSAT CYB5R3 SLC23A1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants FLT3 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function LRAT RBP1 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis PPA1 LHPP PPA2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism MCCC2 ACACA MCCC1 BTD HLCS MTRR PC MTR CBLIF ABCD4 PCCA CUBN MMAA AMN PCCB CD320 MMUT LMBRD1 TCN2 MMAB MMACHC MMADHC INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria CASP4 CALM1 GBP1 GBP6 UBA52 UBE2D2 HBA2 CALM3 UPK1A EPCAM CALM2 GBP2 HBB UBB GBP4 UBC RPS27A LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions STX1B CACNG8 CACNG2 CACNG3 CACNG4 STX1A DLG4 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle RHOT1 RHOT2 RAP1GDS1 TRAK1 MFN1 MFN2 MYO19 TRAK2 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling CASP8 TNFRSF10B TNFRSF10A TNFSF10 TNFRSF10D CASP10 FADD CFLAR BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression PPARA SERPINE1 NAMPT SMARCD3 F7 CHD9 NPAS2 HELZ2 TGS1 BHLHE41 NOCT KLF15 TBL1X BHLHE40 BMAL2 NCOA1 MED1 AVP NCOA2 CREBBP NCOA6 TBL1XR1 CARM1 BMAL1 CLOCK RXRA CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation IGLV3-25 IGLV3-27 PTPN6 IGKC IGLV3-21 CD79B IGKV1-39 CD79A IGKV1-33 IGHV3-53 IGHM IGLC7 IGKV5-2 IGKV1-5 IGLC6 IGHD IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CD22 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 LYN IGKV3D-20 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors YWHAG YWHAZ FOXO6 AKT2 FOXO4 FOXO1 YWHAQ AKT3 SFN AKT1 FOXO3 YWHAB PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors GATA4 NPR1 NKX2-5 NPR2 NPPC CORIN HIPK1 KAT2B WWTR1 MME HIPK2 CES1 NPPA TBX5 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function JUP CTNNB1 SOX10 CDH19 ZC3H12A CTNND1 CTNNA1 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot SERPINB2 ANXA2 HRG PLAT SERPINB8 SERPINE1 SERPINB6 PLAU S100A10 SERPINF2 PLAUR PLG SERPINE2 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly CASP5 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 CASP3 PAK2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs CHUK NFKBIA ZBP1 TBK1 IRF3 NLRP4 DTX4 RIPK3 NFKBIB NFKB2 MYD88 RELA TICAM1 DHX9 IKBKB TLR3 NKIRAS1 NKIRAS2 RIPK1 IKBKG NFKB1 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification ATP6V1H RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking TRAPPC2L SBF2 TRAPPC6A TBC1D20 TSC2 TRAPPC6B TSC1 RAB1A ALS2 RAB1B RAB8A TRAPPC2 TRAPPC3 TRAPPC1 TRAPPC10 TRAPPC4 DENND1C TRAPPC5 DENND1B TRAPPC9 GDI1 DENND5B DENND1A GDI2 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C SBF1 DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 DENND6A RIN1 RIN2 DENND3 RAB21 ALS2CL CHML ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB39B TRAPPC8 RAB12 RAB18 RAB3GAP2 RAB3GAP1 MON1A MON1B RAB11A GAPVD1 RAB3A RAB10 RAB14 RAB13 ARF6 RAB7A YWHAE MAP1LC3B OPTN RAB6A RAB6B RIC1 RGP1 RAB9A RAB9B RABGAP1 GABARAP GGA2 RABGEF1 RAB27B GGA1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B TBC1D2 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B CHM RAB27A RAB5B RAB5C RAB5A AKT2 AKT3 AKT1 RAB3IP DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I VWF CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding GNGT1 STAT3 GBA1 GNGT2 ACTB DCAF7 CCT6B CCNE2 TUBB6 TUBB3 TUBB1 CCNE1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B TUBA4A FBXW2 XRN2 GAPDHS FKBP9 TP53 CCT6A GNAQ HDAC3 GNG10 GNG3 PDCL FBXL3 GNG2 FBXL5 TUBA8 GNG5 WRAP53 TUBA1C GNG4 TUBA1B GNG7 TUBA1A GNG8 KIF13A CCT3 CCT2 CSNK2A1 VBP1 SPHK1 CSNK2A2 TUBB2B TUBB2A CSNK2B SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 GNA15 TUBA3D TUBA3C GNA11 CCT8 CCT7 GNG12 CCT5 GNG11 CCT4 GNG13 NOP56 ARFGEF2 GNB2 TUBB4B TUBB4A GNB1 RGS11 GNB4 GNB3 GNB5 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B CYP2R1 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions BSG ATP1B3 ATP1B2 ATP1B1 MAG SLC3A2 SLC16A1 SLC7A11 L1CAM SLC7A10 ITGB1 ITGA3 SLC7A5 SPN MMP1 SLC7A6 PPIL2 SLC7A7 SLC7A8 SLC7A9 ITGA6 SLC16A8 SLC16A3 CAV1 PPIA FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) HIRA UBN1 RB1 HMGA2 H1-1 H1-0 H1-3 TP53 H1-2 HMGA1 H1-5 H1-4 LMNB1 CABIN1 ASF1A EP400 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling FGF9 FGF20 FGF23 FGF16 SOS1 FGF18 NRAS FRS3 HRAS FRS2 FGF1 FGF2 PTPN11 FGF4 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PPIE LIG1 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 XRCC1 LIG3 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 POLK POLE AQR ERCC8 RFC5 RFC3 RFC4 RFC1 RFC2 PRPF19 ISY1 PCNA POLD3 POLD4 POLD1 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases NTRK3 PPFIA3 PPFIA2 IL1RAPL2 IL1RAPL1 PPFIBP1 PPFIBP2 PTPRS SLITRK2 PTPRF SLITRK1 SLITRK4 SLITRK6 SLITRK3 LRRC4B PTPRD SLITRK5 PPFIA1 PPFIA4 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT PLK1 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG DAGLA ABHD6 ABHD12 DAGLB MGLL COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding TUBA4B TUBA4A CCT6A TUBA8 TUBA1C TUBA1B TUBA1A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 TUBA3E TUBA3D TUBA3C CCT8 ACTB CCT7 CCT5 CCT6B CCT4 TUBB6 TUBB3 TUBB1 TUBB4B TUBB4A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere POLR2I H2AC6 POLR2J H2AC7 POLR2K ACD H2AX POLR2L H3-3B H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 DAXX ATRX H2BC1 H4C9 TINF2 POLR2A POLR2B POLR2C H2AB1 POLR2D H2AZ2 POLR2E H2AC20 POLR2F POLR2G POLR2H H2AC8 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression H2AC6 H2AC7 H2AX SUV39H1 H3-3B TBP H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAF1D H2BC9 TAF1B H2BC8 TAF1C H2BC5 H2BC11 TAF1A H2BC3 SIRT1 RRP8 H2BC1 H4C9 H2AB1 H2AZ2 H2AC20 H2AC8 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 PNMT DDC TH DBH TPH2 ASMT AANAT CAV1 DIO1 DIO2 TPH1 TXNDC11 DIO3 SLC5A5 DUOX1 TPO SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5A STAT5B SOS1 KIT PIK3R3 PIK3R2 PIK3R1 PIK3CA LCK JAK2 STAT1 NRAS LYN STAT3 HRAS YES1 FYN UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CALM1 GRIA3 GRIA4 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 NEFL GRIA2 CAMK2G SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane INPP5E PIK3C2G PIK3C3 FIG4 PIKFYVE TPTE2 PI4KB PIK3C2A PI4K2B PI4K2A VAC14 SACM1L OCRL PI4KA ARF1 PIK3R4 TPTE ARF3 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F2 F12 KLKB1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) TAS2R9 TAS2R19 TAS2R40 TAS2R8 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM3 GRM2 GRM4 GRM7 GRM6 GRM8 TAS2R1 TAS2R30 TAS2R3 TAS2R31 TAS2R5 CASR TAS2R4 TAS2R38 TAS2R39 TAS2R60 TAS1R2 TAS2R50 TAS1R1 GRM1 GRM5 TAS1R3 GPRC6A GABBR2 GABBR1 TAS2R20 TAS2R10 TAS2R13 TAS2R14 TAS2R7 TAS2R16 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection FURIN CD3G IL6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 ADAM17 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 PRKACG IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK GNGT1 GNGT2 GNAT3 AHCYL1 ADCY9 PRKAR1B PRKAR2B PLCG2 PRKACA SYK GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 IGHG3 GNG7 IGHG4 PRKAR1A GNG8 IGHG1 CYSLTR1 IGHG2 IL10 CYSLTR2 CD163 GGT1 PLK2 DPEP2 RHBDF2 DPEP1 MYH9 GNAZ GGT5 FCGR3A LYN FGR YES1 GNG12 ADORA2B GNG11 FCGR1A GNG13 GNB2 GNB1 FCGR2A GNAS GNB4 GNB3 GNB5 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression AP2M1 CD28 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling PTPN6 RAPGEF1 SOS1 PRKACA CRK BLNK SYK IL2RG INPPL1 JAK3 INPP5D JAK1 VAV1 PIK3CD PIK3CB CBL STAT5A STAT5B YWHAZ HCK GAB2 TEC PIK3R3 PIK3R2 PIK3R1 PIK3CA SHC1 JAK2 CRKL IL2 IL3 LYN YES1 IL5RA CSF2RB CSF2RA FYN IL5 IL2RB IL3RA PTPN11 CSF2 IL2RA INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption RSC1A1 SLC2A2 SLC5A1 SLC2A5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization VAV1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 GRAP2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 TXK IGKV3D-20 V5-6 IGHE PPP3CA IGLV3-19 PPP3CB IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 PPP3R1 IGHV3-48 NFATC3 IGLV3-25 NFATC2 IGLV3-27 NFATC1 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 TEC AHCYL1 BTK PLCG2 VAV3 SYK VAV2 ITPR1 ITPR2 ITPR3 LYN ITK LCP2 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) SLC6A19 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD2 ENTPD5 ENTPD3 ENTPD4 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping MAPK8 CYBA DVL1 DVL2 NOXO1 NOXA1 DVL3 WNT5A JUN FZD7 NOX1 RAC1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling CBFB RUNX1 ESR1 RSPO3 FOXP3 AXIN1 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 SETD9 ATM EP300 JMY UBA52 CHEK2 TP53 EHMT2 EHMT1 MDM2 TTC5 MDM4 PRMT5 SMYD2 UBB UBC KMT5A RPS27A BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion CD4 CCR5 CXCR4 PPIA ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO BOC KIF3A GAS1 PTCH1 ARRB1 CDON IHH DHH ARRB2 GRK2 SHH CSNK1A1 EVC2 IQCE EFCAB7 EVC DRC4 SMO TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production PRKAR2B PRKACA PRKACG GNAI3 ADCY4 PRKACB ADCY3 PRKX IL6 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 PRKAR1A GNAZ GNGT1 GNGT2 GNG12 ADORA2B GNG11 GNG13 GNB2 GNB1 GNAT3 GNAS GNB4 GNB3 GNB5 ADCY9 PRKAR1B CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 JAG2 JAG1 ADAM10 DLL1 DLL4 ADAM17 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling JAK1 STAT5A STAT5B PTK2B SYK IL2RB IL2RG JAK3 SHC1 LCK IL2RA IL2 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis CASP8 RIPK3 MLKL RIPK1 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle CDC42EP1 GIT2 DOCK2 ARHGAP26 DOCK1 TAOK3 RAB7A ABI2 EPHA2 VAMP3 ABI1 GARRE1 ARHGAP39 ARHGAP21 LMAN1 PAK4 TFRC MCF2 MCAM ERBIN VAV1 MPP7 SAMM50 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 VAPB ESYT1 PAK1 MTX1 RAC2 PAK2 DOCK3 DSG2 PLD2 TIAM1 CAV1 CDC42EP4 VAV3 DEF6 VAV2 ARMCX3 LBR PGRMC2 NCKAP1 NCF1 NCF2 NCF4 ITGB1 BRK1 CYFIP1 DOCK10 ANKLE2 SYDE1 PIK3R3 DOCK4 ARHGAP42 PIK3R2 IQGAP1 TRIO BAIAP2L1 PIK3CA PIK3R1 ARHGAP1 GIT1 SWAP70 ARHGAP35 CYBB PREX1 OPHN1 ARHGDIA CYBA STBD1 BCR CDC42 EMD ARHGAP17 TMPO ABR RACGAP1 VRK2 NHS LEMD3 SLITRK5 NCKAP1L DEPDC1B WASF2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL PIP5K1B CSNK2B CSNK1E DVL1 DVL2 DVL3 CSNK2A1 CSNK2A2 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A AKT2 FOXO1 AKT3 AKT1 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions VTN H3C8 CTNNB1 H3C15 RICTOR H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 SNW1 ELAVL1 C4BPA C4BPB CLU NEK2 H2AC8 H2AC6 EXOC1 H2AC7 SNRPD2 SNRPD1 SNRPD3 GBF1 SNRPG SNRPE LY96 PRR5 SNRPF SNRPB H2BC26 H2BC21 MLST8 H2BC17 C4A H2BC12 C4B_2 H2BC13 H2BC14 H2BC15 APOA1 H2BC11 TLR4 MTOR H2BC18 COG1 BECN1 NCBP1 NCBP2 FIP1L1 IFIH1 TRIM25 GRPEL1 MAVS PQBP1 HSPG2 SDC4 TAL1 SDC2 SRRT SDC3 SNRNP200 FUS HSP90AB1 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA0 HNRNPA3 SDC1 GPKOW CDC5L CCAR1 CD2BP2 PCBP1 CPSF7 PCBP2 RBM10 DDX5 RETREG1 SUGP1 DHX15 VIM HNRNPC DHX16 RBMX PEX19 HNRNPA2B1 WBP11 HNRNPUL1 PPIE DDX3X DDX46 RPTOR DDX42 RBM17 DYNLT1 GPC1 BUD31 MMP9 GPC3 RBM22 DDX23 GPC2 SMNDC1 GPC5 U2SURP HNRNPR GPC4 STAT2 NRBP1 GPC6 CPSF1 CSTF3 ATG14 CPSF3 CSTF2 CPSF2 AGRN CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 XAB2 PHF5A DAXX AUP1 CLEC5A TXNL4A SNRPN CHERP HSPA8 PTBP1 PLRG1 SNRPA1 DNAJC8 PUF60 SNRPB2 PPIL1 SNRNP40 PPIL3 PPIL4 PPIL6 SRRM2 AQR CPSF4 CRNKL1 PIK3R4 PRPF19 HNRNPH1 HNRNPH2 CWC25 PDCD6IP PIK3C3 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 HSP90AA1 CWC15 ELAVL2 RBM5 RIPK1 PABPN1 RPL18 CDC73 TAOK1 SKIC8 CTR9 RTF1 IKBKE LEO1 PAF1 NFKBIA FASN HNRNPU NFKBIB TJP1 EIF4A3 UBE2I F2 CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SRSF9 GTF2F1 GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 H2AC17 H2AC12 U2AF2 DHX38 CAMK2B SRSF11 CAMK2D H2AC1 CAMK2A ALYREF H2AC19 H2AC25 H2AC14 H2AC21 RNPS1 CAMK2G UBR4 MBL2 MAPKAP1 C1QA C1S CGAS H4C9 DHX9 H2AC20 STING1 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription WWTR1 TEAD3 CCN2 TEAD4 YAP1 TEAD1 RUNX3 TEAD2 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling DOCK1 WASL PTK2 TRIO RAC1 NCK1 DCC ABLIM1 ABLIM2 NTN1 ABLIM3 CDC42 SRC DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors LTB4R PTGER4 PTGER2 PTGER3 TBXA2R PTGFR PTGIR LTB4R2 PTGDR2 OXER1 PTGER1 PTGDR GPR17 CYSLTR1 CYSLTR2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) GSDMD MEFV CTSG NFKB2 RELA NT5E PYCARD HSP90AB1 NFKB1 HMOX1 C3 CASP1 NLRP3 IL18 PSTPIP1 IL1A IL1B P2RX7 P2RX4 TXNIP TXN C3AR1 SUGT1 ENTPD1 ENTPD5 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction MYBPC3 TMOD1 MYBPC1 MYBPC2 ACTN3 TMOD4 TNNC1 TMOD2 TNNC2 NEB DMD MYL4 MYH3 DES MYL1 TNNT1 MYL2 TNNT2 ACTN2 MYL3 TNNT3 MYH8 TCAP MYH6 TTN TNNI3 TMOD3 TPM4 TPM3 TPM2 VIM TPM1 TNNI1 TNNI2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) MPG LIG1 POLE PARG RFC5 RFC3 ADPRS RFC4 RFC1 RFC2 FEN1 OGG1 NTHL1 TDG MBD4 SMUG1 PCNA NEIL2 POLD3 NEIL1 PNKP POLD4 POLD1 POLD2 PARP1 PARP2 POLB APEX1 XRCC1 LIG3 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins POM121C SUMO2 NUP42 AURKA NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 CDCA8 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 TOP2A PCNA TOP2B NUP133 PIAS4 PIAS3 RANGAP1 TOP1 UBE2I INCENP BIRC5 NUP205 POM121 NUP107 NUP188 AURKB SUMO1 AAAS SUMO3 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 DNM2 DPYSL2 AP2A1 AP2A2 SHTN1 AP2M1 EZR RPS6KA1 RDX MSN L1CAM KIF4B KIF4A RPS6KA5 AP2S1 SH3GL2 CLTC DNM1 CLTA DNM3 NUMB RPS6KA3 AP2B1 RPS6KA2 MAPK1 RPS6KA6 RPS6KA4 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA AFF4 ELOB CDC73 NELFB MLLT1 ELOC MLLT3 NELFCD SUPT6H NELFA IWS1 NELFE EAF1 SUPT16H EAF2 TBP NCBP1 SKIC8 NCBP2 GTF2A1 GTF2A2 CTR9 CTDP1 RTF1 TAF9 SUPT4H1 TAF1L LEO1 GTF2E1 GTF2E2 TAF15 TAF12 TAF13 PAF1 TAF10 TAF11 ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora NHLRC1 GYG1 EPM2A UBB UBA52 UBC GYS1 RPS27A PPP1R3C NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 XPO1 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription NOTCH1 NOTCH2 EP300 RBPJ MAML2 CREBBP MAML1 NOTCH4 HEY1 FLT4 KAT2B HEY2 KAT2A ACTA2 MAMLD1 SNW1 SMAD3 HES1 HES5 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 STAT3 PTK6 SOCS3 STAP2 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants FZD8 LRP5 FZD5 FZD4 LRP6 WNT3A FZD6 RNF43 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies SI LCT CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine H2AC6 H2AC7 ACD H2AX MPG H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 H2BC17 H2BC12 H2BC13 NEIL3 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils BMP1 PCOLCE TLL2 TLL1 LOX LOXL3 LOXL4 LOXL1 PXDN LOXL2 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins DNAJB11 NMT1 DPM1 DPM2 DPM3 KPNA1 MAGT1 UBA52 UBB UBC RPS27A HSPA5 ACOT2 UBE2I IPO7 P4HB KPNA7 TUSC3 KPNA4 P4HA1 P4HA2 KPNA5 P4HA3 SUMO1 KPNA2 KPNA3 SCAP TMEM258 SEC11A SEC11C HYOU1 PRKG2 OST4 OSTC STT3A KPNB1 STT3B XPO1 RPN2 CALR DDOST SPCS3 RPN1 SPCS2 SPCS1 DAD1 PDIA3 APOA1 DNAJC10 DNAJC3 CANX DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling CHUK CD4 HLA-DRB3 HLA-DRB1 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 CD3G PSMA1 PSMA2 CD3E UBA52 CD3D CARD11 UBE2D1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 INPP5D RIPK2 BCL10 PSMA7 RELA HLA-DPA1 MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 HLA-DQB2 UBC HLA-DQB1 PSMB1 RPS27A ADRM1 TRAT1 NFKB1 SEM1 TRBV12-3 NFKBIA PSMC5 PSMC6 TRBV7-9 PSMC3 PSMC4 PSMC1 PSMC2 UBE2D2 TRAV8-4 HLA-DPB1 TRAC CDC34 PRKCQ UBE2V1 TRAV19 HLA-DRA PTEN TRBC1 PIK3CB UBE2N PDPK1 TAB2 PIK3R2 PIK3CA PIK3R1 LCK TRAV29DV5 HLA-DQA2 HLA-DRB5 PSMD8 HLA-DRB4 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters CD4 CD8B AP2A1 AP2S1 AP2A2 LCK AP1G1 PACS1 AP2M1 AP1S2 AP1B1 AP2B1 AP1S1 AP1S3 HLA-A ATP6V1H ARF1 B2M AP1M2 AP1M1 CD28 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription CBX6 PHC2 EZH2 PHC1 SALL4 MTA2 CBX4 CBX2 REST RCOR1 RPTOR JUN PHC3 RRAGA RRAGC BMI1 RRAGB RRAGD RING1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 RNF2 LAMTOR3 LAMTOR5 ATN1 MAF1 MTA1 HDAC1 SUZ12 MTA3 MAPK1 MAPK3 SNAI2 PPARG TP53 NR2E1 ATF2 HDAC3 MECOM MBD3 MLST8 EED GATAD2B GATAD2A EGR1 HDAC5 KDM1A HDAC2 HDAC7 SNAI1 CHD4 RBBP4 CHD3 RBBP7 MTOR CBX8 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic GOSR1 TMED2 ARF4 ACTR1A SEC22B RAB1A TMED10 COPZ2 COPZ1 GOSR2 GALNT2 RAB1B KIF4B KIF4A MAN1A2 MAN1C1 MAN1A1 RAB41 KIF20A RAB30 KDELR3 KLC1 RAB36 KLC4 KLC3 DCTN1 KLC2 KIF11 KIF15 AGPAT3 ARF1 BET1L KIF23 KIF22 NSF KIF26A M6PR DCTN2 DCTN3 DYNC1LI1 RAB39A DYNC1LI2 ZW10 RAB18 RAB3GAP2 VPS45 RAB3GAP1 GBF1 TMED3 TMED7 TMED9 TRIP11 KIF18A COPG2 COPG1 COPB2 COPA COPB1 DYNLL1 MAN2A2 COPE DYNLL2 ARFGAP1 KIF2A USP6NL SCOC KIF2C CUX1 SYS1 KIF2B GCC2 GCC1 RACGAP1 RABEPK PAFAH1B1 RAB43 DYNC1I2 GOLGA4 GOLGA1 ARFIP2 ARFGAP3 NAA30 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 DYNC1I1 NAA35 VAMP3 NAA38 VAMP4 NAPA DYNC1H1 NAPB TMF1 STX16 CENPE RHOBTB3 ARL1 DCTN6 DCTN5 NAPG STX5 DCTN4 STX10 YKT6 TGOLN2 BICD1 BICD2 ARFRP1 VPS51 CAPZA3 VPS53 ACTR10 PAFAH1B3 VPS52 VTI1A PAFAH1B2 STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B GOLIM4 CAPZB RAB33B CYTH3 CYTH2 GOLGA5 PLIN3 CYTH4 SNAP29 CYTH1 ALPP MAN2A1 CAPZA1 CAPZA2 PLA2G6 GALNT1 ARF5 KIF5C PLA2G4A ARCN1 KIF5B KIF5A KIFAP3 KIF28P KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KDELR2 KIF25 KIF6 KIF27 RINT1 ARFGAP2 KIF9 KIFC2 KIF16B KIFC1 KIF20B KIF3B KDELR1 KIF3A NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF3C ARF3 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME CYP2C19 BSG CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP2E1 CES1 UGT1A3 SLC16A1 BCHE CES2 GLYATL3 GLYATL2 GLYATL1 ACSM2A UGT2B10 ACSM5 UGT2B11 ACSM4 UGT2B15 GLYAT UGT2B17 UGT3A2 UGT3A1 UGT2A3 UGT2A2 UGT2A1 UGT1A1 ACSM2B ABCC2 UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 ABCC3 ALB UGT1A6 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events EP300 LIN54 PLK1 LIN52 LIN37 PKMYT1 LIN9 CDC25C CDC25A WEE1 CENPF CCNB1 CCNB2 RBBP4 MYBL2 FOXM1 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants FLT3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA TRIM32 ZBP1 TBK1 IRF3 NLRP4 DTX4 TRIM21 UBA52 DDX41 TRIM56 UBB UBC TREX1 RPS27A STING1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX CYP27A1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 NUP85 EIF4E NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS1L1 PRPS2 PRPS1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells NEUROD1 IAPP NKX6-1 NKX2-2 PDX1 INS PAX6 HNF1A MAFA FOXO1 RFX6 FOXA3 GCK FOXA2 SLC2A2 AKT2 HNF4G AKT3 AKT1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PPP2R1B PPP2R1A PRKACA PRKACG PFKFB2 PFKFB1 PPP2R5D PRKACB PFKFB4 PFKFB3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 SGCE LAMA4 SNTG2 LAMA3 FN1 SGCD LAMC2 SGCA SGCB LAMB1 DMD LAMC1 VTN SGCG SNTA1 DTNA KLKB1 DTNB SGCZ SSPN SNTB1 SNTB2 PRSS1 CTRB2 CDH1 CTRB1 TRAPPC4 PDGFA BMP10 CTSV CTSL CTSK ADAM10 ADAM17 PTPRS F11R ICAM1 CEACAM1 COL17A1 COL18A1 PXDN COL15A1 COL16A1 COL13A1 ICAM2 COL14A1 ICAM3 COL11A1 COL11A2 BMP4 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 ITGB1 COL24A1 COL25A1 COL22A1 COL23A1 COL3A1 COL2A1 COL4A2 COL5A1 NRXN1 COL4A1 COL7A1 BMP2 COL6A2 COL5A3 COL4A4 COL5A2 COL6A1 COL4A3 COL4A6 VCAM1 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CAST SERPINE1 SPARC CAPNS1 CAPNS2 LOX LOXL3 CAPN2 LOXL4 CAPN1 LOXL1 KLK2 LOXL2 PSEN1 CAPN15 PHYKPL NCSTN OPTC KLK7 PDGFB GDF5 DDR1 ELN KDR MMP20 MMP25 MMP24 TPSAB1 A2M MMP10 MMP12 MMP11 CEACAM6 MMP15 MMP17 MMP19 CEACAM8 DDR2 TMPRSS6 MMP1 EFEMP2 CAPN8 EFEMP1 CAPN9 CAPN6 P4HB CAPN7 CAPN5 CAPN3 ADAM9 ITGAM ADAM8 ITGB2 TNC FBN2 ICAM4 FBN3 ICAM5 CD151 HTRA1 ITGAE COMP FBLN1 IBSP FBLN2 FBLN5 ITGAX SCUBE3 ITGB7 SCUBE1 ITGAD CD47 MMP8 JAM2 SPOCK3 JAM3 MFAP5 ITGA11 ITGAV CAPN13 CTSG FBN1 MFAP4 CAPN14 CAPN11 DAG1 CAPN12 CAPN10 MFAP3 HSPG2 MFAP2 SDC4 SDC2 SDC3 MMP7 PECAM1 COLGALT2 PLOD3 PLG PLOD2 PLOD1 COLGALT1 P3H2 P3H1 PCOLCE P3H3 PCOLCE2 SERPINH1 SDC1 CRTAP ACTN1 SH3PXD2A ADAM19 CTSD MMP2 ITGA2B FURIN CD44 PPIB MMP9 NCAN BGN COL1A1 DCN COL1A2 PLEC BCAN FMOD VCAN AGRN ITGA10 ITGB5 ITGA9 NCAM1 P4HA1 P4HA2 P4HA3 CASK BSG MMP13 ADAMTS4 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTS1 SPP1 ADAMTS8 ADAMTS9 TGFB1 FGF2 ADAMTS16 ADAMTS14 ITGB4 ADAMTS18 ITGA3 ITGA2 ITGA1 NID1 NID2 ITGA7 ITGA6 ACAN LUM ELANE HAPLN1 TNN TNR MUSK ASPN MATN1 MATN4 TNXB LRP4 DSPP ADAM15 ADAM12 UTRN CMA1 NTN4 BMP7 CASP3 TTR DRP2 TIMP2 TIMP1 TGFB2 DMP1 PRSS2 MMP14 MMP16 PRKCA LTBP4 LTBP2 LTBP3 ITGAL LTBP1 ITGB8 THBS1 CTSS ITGB6 CTSB TGFB3 ITGA8 ITGA4 ITGB3 MMP3 ITGA5 MATN3 FGB FGA BMP1 TLL2 FGG TLL1 LAMA5 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events AKT2 PDE3B DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis GYG2 GYG1 EPM2A GBE1 UBA52 GYS2 GYS1 PPP1R3C NHLRC1 UGP2 UBB UBC PGM1 RPS27A SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste SCNN1A CALHM1 SCNN1G SCNN1D SCNN1B CALHM3 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions COL9A2 COL6A5 CACNA1S PRNP PSPN NCAN ST8SIA4 CACNA1C ST8SIA2 GFRA1 AGRN CNTN2 GDNF CACNA1H CACNB1 CACNB2 CACNB3 CACNB4 CACNA1G CACNA1I COL4A2 COL4A1 COL6A2 COL4A4 NCAM1 ARTN COL6A1 COL4A3 COL9A1 GFRA2 CACNA1D GFRA4 COL6A3 COL4A5 COL9A3 NRTN COL6A6 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall FN1 SHC1 IGHV3-23 NRAS IGLV IGLV2-8 IGKV1-16 IGKV1-17 HRAS IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 CD74 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 F11R V2-8 V1-20 CEACAM1 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 APOB IGKV3-20 ITGB1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 LCK IGLC3 IGLC1 IGLC2 SPN V1-9 V5-4 PPIL2 V1-7 V5-1 V1-5 SLC16A8 V1-3 IGKV3D-20 V5-6 SLC16A3 FYN IGLV3-19 IGKV2-30 PPIA IGHV2-70 IGHV2-5 PTPN11 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 PTPN6 IGKC IGLV3-21 FCER1G IGKV1-39 GP6 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 SLC3A2 SLC7A11 SLC7A10 CEACAM6 CEACAM8 SLC7A5 SLC7A6 MMP1 SLC7A7 EPCAM SLC7A8 SLC7A9 CAV1 PROC ITGAM ITGB2 ITGAX CD47 JAM2 JAM3 ITGAV VPREB3 SELP VPREB1 CXADR PSG1 SDC4 PSG3 SDC2 PSG2 SDC3 PSG9 FCAMR PSG8 PECAM1 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 OLR1 CEACAM3 CD48 SDC1 SELPLG CD58 IGLL1 CD84 SIRPG SIRPA JAML PSG11 CD99 GRB7 SELE SELL ESAM TREM1 CD2 CD244 PF4 CD44 IGHM GPC1 INPP5D MAG L1CAM BSG TSPAN7 CEACAM5 SLC16A1 TGFB1 PICK1 ITGA3 ITGA6 TNFRSF10B TNFRSF10A PROS1 MERTK GAS6 F2 ANGPT1 TEK THBD PF4V1 CD177 PROCR DOK2 ATP1B3 TNFRSF10D ATP1B2 ATP1B1 IGHA1 IGHA2 ANGPT4 JCHAIN ANGPT2 GRB14 ITGAL ITGA4 ITGB3 ITGA5 PIK3R2 MIF PIK3R1 LYN YES1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation ACD PRIM2 PRIM1 POLA1 POLA2 CTC1 TINF2 STN1 TERF1 TEN1 TERF2 POT1 TERF2IP GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants FLT3 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE CEPT1 CHKB CHKA SELENOI PHOSPHO1 ETNPPL ETNK2 ETNK1 PCYT2 PISD LPIN1 LPIN2 LPIN3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors GRIP2 GRIA1 PRKCB AP2A1 TSPAN7 GRIA3 GRIA4 PRKCA GRIP1 NSF PRKCG GRIA2 PICK1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand ACD DNA2 PCNA POLD3 POLD4 WRN POLD1 POLD2 TINF2 RPA1 RPA2 TERF1 TERF2 RPA3 POT1 TERF2IP FEN1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 MDM2 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 VHL PIAS4 UBE2I PIAS1 NUP205 POM121 NUP107 NUP188 TRIM27 SUMO1 AAAS PML PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 PIK3R1 PIK3CA FGFR4 GAB1 KLB FRS2 FGF1 FGF2 PTPN11 FGF4 FGF6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism MANBA MAN2B2 MAN2B1 MAN2C1 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC67A1 SLC22A5 SLC22A2 SLC22A1 SLC47A2 SLC22A4 RSC1A1 SLC14A1 RUNX1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC22A3 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism UST CHST3 IDUA HEXB NCAN HEXA BGN DSE DCN GLB1L3 GLB1L2 CHST11 CHST12 BCAN CHST15 VCAN CHST13 GLB1L CHPF GLB1 HYAL1 CHST14 CHPF2 HYAL3 HYAL4 CSPG5 IDS CSGALNACT1 CSPG4 GUSB ARSB CSGALNACT2 CHST7 CHSY1 CHSY3 DSEL THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model SLC25A27 UCP3 UCP2 SLC25A14 UCP1 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation SNAI1 EOMES FGFR1 TBXT AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation ARHGDIA RHOA NGF NGFR CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication LAMB3 EZH2 H2AX CDH4 LAMA3 LAMC2 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B CLDN2 H3C8 MTBP ZC3H12A CSNK2A3 CLDN6 H2AJ CLDN4 CLDN3 SRC CLDN9 CTNND1 CLDN8 CLDN7 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 CLDN22 CLDN20 ZMYM2 CLDN23 RACK1 CLDN11 CLDN10 CLDN15 CLDN14 SUZ12 CLDN12 H2BC9 CLDN19 H2BC8 CLDN18 H2BC5 CLDN17 CLDN16 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST SDK1 H2AC8 SDK2 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 PARD6G PARD6B MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 PXN PATJ F11R COL17A1 PALS1 ZEB1 CRB3 PARD6A PARD3 PIK3CB H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 ITGB1 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 FYN RBBP7 H2AZ2 PTPN11 TGIF2 TNRC6C PTPN6 DOCK1 TNRC6A ACTN3 TNRC6B ARHGEF4 FERMT2 ARHGEF6 ACTN4 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PTK2B PRKCSH SNAI2 GANAB CD151 CD47 WASL MOGS PTK2 TCF12 VAV2 FLNA ACTN2 VASP SIRPG PRDM8 SIRPA BHLHE22 KDM1A CDH8 ACTN1 CTNNA1 NCK2 CDH24 NCK1 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 CLDN5 SNAI1 DST TESK1 CD2AP SKAP2 ZNF217 RSU1 PARVA PARVB FLNC LIMS2 FURIN PCSK6 LIMS1 KIRREL3 KIRREL1 KIRREL2 MAGI2 FBLIM1 ANK3 ILK SIRPB1 NPHS1 TYK2 SPTBN1 PLEC RB1 SPTAN1 POMT2 CASK DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 ITGB4 ITGA6 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PRKCI PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CLDN1 TYROBP RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 PIK3R2 IQGAP1 PIK3R1 JAK2 H4C9 FYB1 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres PPP6C ACD PPP6R3 LIG1 PRIM2 PRIM1 POLA1 POLA2 TERF1 TERF2 CCNA2 CCNA1 POT1 TERF2IP FEN1 ANKRD28 GAR1 CDK2 DSCC1 RUVBL2 SHQ1 PIF1 CHTF8 RFC5 CTC1 CHTF18 RFC3 TERT STN1 WRAP53 RFC4 TEN1 RFC1 RFC2 DNA2 DKC1 NHP2 BLM RTEL1 PCNA POLD3 POLD4 WRN RUVBL1 POLD1 NOP10 POLD2 TINF2 RPA1 RPA2 RPA3 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification SERPINA1 PPP6C GOSR1 TFG PPP6R1 PPP6R3 TMED2 ARF4 CTSC TRAPPC2L LMAN1L ANK2 ANK3 F5 ANK1 F8 TRAPPC6A TBC1D20 ACTR1A TRAPPC6B GORASP1 PREB CHST10 GOLGB1 SEC22B SPTBN4 SEC22A SPTBN5 SEC22C SPTA1 RAB1A TMED10 LMAN2L ST8SIA6 SPTBN1 COPZ2 STX17 SPTBN2 COPZ1 GOSR2 RAB1B USO1 SCFD1 ST8SIA2 LMAN2 CD59 SEC31B ST8SIA3 SEC31A MAN1A2 ANKRD28 MAN1C1 TRAPPC2 MAN1A1 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SPTAN1 SEC23IP CNIH1 SPTB KDELR3 CNIH2 CNIH3 DCTN1 FOLR1 BET1 ARF1 CTSZ FUT3 BET1L AREG SEC23A NSF SAR1B MANEA GRIA1 DCTN2 LHB DCTN3 SEC24B DYNC1LI1 SEC24A DYNC1LI2 B4GALT2 B4GALT3 B4GALT1 GBF1 TMED3 SEC24D TMED7 SEC24C TMED9 B4GALT6 SEC13 COPG2 COPG1 COPB2 COPA B4GALT4 B4GALT5 COPB1 DYNLL1 MAN2A2 TMEM115 COL7A1 COPE DYNLL2 ARFGAP1 DYNC1I2 ARFGAP3 COG8 COG7 COG6 COG5 COG4 INS COG3 COG2 COG1 DYNC1I1 NAPA DYNC1H1 NAPB DCTN6 LMAN1 GOLGA2 DCTN5 NAPG STX5 DCTN4 YKT6 CAPZA3 ACTR10 FUCA1 CAPZB FUT8 MAN2A1 MGAT5 CAPZA1 ST3GAL4 MGAT3 CAPZA2 MGAT1 CHST8 MGAT2 CGA ST6GAL1 MGAT4C ARF5 MGAT4A MGAT4B ARCN1 CSNK1D CD55 KDELR2 MIA3 ARFGAP2 KDELR1 MIA2 ARF3 MCFD2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation CTNNB1 MET CDKN1A CDKN2A TCF7 PLK1 HDAC1 CCND1 CDC25B CCNB1 HINT1 LEF1 CDK2 TCF7L2 SIN3A TCF7L1 TBX2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD3G CD3E CD3D HLA-A B2M CDH1 TRBV12-3 TRBV7-9 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 TRAV8-4 IGHV3-9 PVR V2-11 IGHV3-30 V3-4 CD81 V3-3 V2-17 TRAC V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CD19 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 NECTIN2 TRAV19 IFITM1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 ICAM1 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ICAM2 IGLV7-43 ICAM3 IGKV1D-12 IGLV1-51 IGLV2-23 C3 CD22 IGKV3-20 ITGB1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 VCAM1 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CD8B ITGB2 ICAM4 ICAM5 ITGB7 CXADR JAML CD99 SELL FCGR3A TREM1 FCGR1A CD226 CD1D CD1C CD1B cd21 CD1A KLRK1 SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 KIR2DS2 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 SIGLEC9 NCR1 NCR2 CD200R1 NCR3 HCST LILRA6 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA LAIR1 MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 LILRB2 KIR3DL2 LILRB3 LILRB4 LILRB5 CD40LG SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 SIGLEC5 CD96 OSCAR CD8A KLRF1 CD300E CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG CD160 HLA-H CRTAM COLEC12 HLA-C KLRD1 HLA-F ULBP1 ULBP3 HLA-G PIANP HLA-E KLRG1 CLEC2B FCGR2B CLEC2D HLA-B CD33 TREM2 CD300A TYROBP ITGAL TRBC1 ITGA4 TRAV29DV5 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling EIF4G1 LAMTOR5 FKBP1A RPTOR EEF2K RPS6 RRAGA RRAGC RRAGB RRAGD AKT1S1 EIF4EBP1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 MTOR LAMTOR4 MLST8 LAMTOR3 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes H2AX ASH2L CCNC PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2C GPAM SCD ADIPOQ HDAC3 PHLDA1 ACSL1 PEX11A DPY30 H2BC26 H2BC21 CIDEC WDR5 EP300 TBL1X H2BC17 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 CREBBP NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 PDK4 ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL LIPE DGAT2 MED30 MED31 KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling CDC14A PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 JUN PRKACG UBA52 PSMD12 PRKACB PSMD11 FOXO3 RAC1 PSMD14 KALRN PSMD13 PSMA7 PSMB6 CDK1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FOXO1 PAK3 CCND3 PAK2 SEPTIN7 CDC14B ETV4 IGF2BP1 MAPK6 MAPK4 CDC42EP5 CDC42EP3 RAG2 CDC42EP2 PRKACA RAG1 HSPB1 MYC XPO1 NCOA3 CDC42 PSMD8 PSMD6 MAPKAPK5 PSMD7 PSMD2 MOV10 PSMD3 AGO3 PSMD1 AGO4 AGO1 DNAJB1 AGO2 TNRC6C DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 GPC5 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 IHH SHH P4HB VCP SEL1L ADAM17 DHH HHAT DISP2 SCUBE2 SYVN1 NOTUM ERLEC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 KIF5A CDC42 RHOA KTN1 RHOG KLC1 KLC4 KLC3 RAC1 KLC2 KIF5B CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII SOS1 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF CBL DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown POM121C NUP42 PRKCB NUP62 NUP43 TPR BANF1 NUP88 RAE1 NUP214 RANBP2 NDC1 PLK1 NUP210 NUP155 PRKCA NUP153 CCNB1 NUP93 LMNB1 NUP50 NUP35 NUP54 NUP160 CDK1 CCNB2 NUP85 CTDNEP1 CNEP1R1 NUP37 NEK9 VRK1 NEK6 LEMD2 NEK7 SEC13 NUP133 EMD NUP205 POM121 NUP107 LEMD3 LPIN1 NUP188 LPIN2 AAAS LPIN3 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 NOTCH1 NOTCH2 LFNG NOTCH3 NOTCH4 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones FSHB INHBB INHBC CGA INHBE INHBA TSHB LHB CGB8 INHA PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer TSC2 RAC1 MDM2 AKT1S1 VAV1 SRC TGFA MET CDKN1A RICTOR EREG CDKN1B BTC EPGN HBEGF NTRK2 BDNF GAB1 NTF4 NTF3 CD86 EGF CD80 FRS2 FLT3 AREG CD19 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF PRR5 GSK3B IRS2 PIK3CD FGF1 BAD FGF2 PIK3CB CASP9 FGF3 PIK3CG NRG1 FGF4 FGF6 FGF7 MLST8 FGF9 FGF20 FGF23 FGF22 PDPK1 GAB2 FGF16 FGF19 FGF18 FGFR4 PIK3CA FGF10 LCK FYN RHOG PTPN11 MTOR CHUK FOXO3 PDGFRA PDGFRB TRAT1 PDGFB NTRK3 PIK3AP1 FLT3LG FOXO6 FOXO4 KIT FOXO1 RPS6KB2 RAC2 ESR1 GSK3A ESR2 NR4A1 PTEN AKT2 AKT3 AKT1 ERBB2 STRN MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 CD28 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation COL9A2 MMP13 FURIN MMP8 PRSS2 ADAM10 MMP14 ADAM17 MMP9 MMP7 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 CTSB COL14A1 PHYKPL COL12A1 COL19A1 MMP20 COL26A1 COL25A1 MMP3 MMP10 MMP12 COL23A1 MMP11 MMP15 MMP19 TMPRSS6 MMP1 CTSD COL9A1 ADAM9 CTSL CTSK MMP2 COL9A3 ELANE FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex AXIN2 H2AX PYGO1 PYGO2 ASH2L BCL9L BCL9 MEN1 CDC73 RUNX3 H3-3B H3C8 H2AJ LEO1 CTNNB1 H3C15 KMT2B HDAC1 H2BC9 H3-4 TLE4 H2BC8 TLE2 H2BC5 H2BC3 H2BC1 SMARCA4 H2AB1 TLE1 H2AC8 H2AC6 H2AC7 TCF7 KAT5 H2AC19 H2AC14 H2BC12L TERT MYC DPY30 H2BC26 H2BC21 WDR5 EP300 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP TLE3 H2BC11 RUVBL1 LEF1 H4C9 TRRAP RBBP5 TCF7L2 H2AZ2 TCF7L1 H2AC20 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members FURIN UBE2M TGFBR1 TGFBR2 TRIM33 CCNC UBE2D1 MEN1 MYOG MYOD1 MYF6 TCF4 PPM1A MYF5 COL1A2 ITGB5 CBL CDKN2B NEDD8 MAPK1 SNW1 TFDP1 MAPK3 TFDP2 SKIL ACVRL1 BMP10 BMPR2 AMHR2 FSTL1 CHRDL1 AMH NOG GDF2 PPP1CC SMAD9 MYCN SMAD5 GREM2 ZFYVE16 CDK8 BMPR1B BMPR1A STRAP SP1 ARHGEF18 CGN F11R PRKCZ TGFB1 RHOA PARD6A FGF2 PARD3 XPO1 USP9X EP300 SKI ITGB1 BMP2 PARP1 TCF3 NCOR1 UBE2D3 ACVR1C TGIF1 ACVR1B ACVR2B TGIF2 CER1 TNRC6C FKBP1A TNRC6A TNRC6B CCNK CCNT2 CCNT1 UBA52 STUB1 SERPINE1 FST FOXH1 JUNB DRAP1 RNF111 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B NEDD4L CDK9 PPP1CB HDAC1 ATP1B4 PPP1CA SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 RXRA SMURF1 SMAD6 TIMP2 TIMP1 RARA SMAD7 HELLS TGFB2 INHBA KLF16 ACVR2A ITGAV TGFBR3 MMP14 MMP16 GIPC1 INHA YBX1 TCF12 NCOR2 PPP1R15A USP15 LTBP4 RBL1 LTBP2 LTBP3 MTMR4 MYC LTBP1 ITGB8 PMEPA1 ITGB6 TGFB3 UCHL5 BAMBI ITGA8 INHBB ITGB3 ARRB1 ARRB2 FSTL3 E2F4 WWTR1 E2F5 MOV10 AGO3 AGO4 AGO1 AGO2 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR PTPN3 ARHGEF7 UBA52 UBB SH3GL3 SH3KBP1 SRC UBC RPS27A STAM CBL HGS ADAM12 EPS15 TGFA STAM2 SH3GL2 SH3GL1 EREG BTC EPGN HBEGF SHC1 NRAS GAB1 HRAS PLCG1 EGF AREG PTPN12 ADAM10 SOS1 ADAM17 EGFR PXN AAMP PTPRK LRIG1 FAM83D PAG1 FAM83A SPRY1 SPRY2 PIK3CA PIK3R1 EPS15L1 EPN1 CDC42 FAM83B CSK PTPN11 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB PPP2R1A MKNK1 SPRY2 UBA52 MAPK1 MAPK3 UBB BRAF UBC PTPN11 RPS27A CBL E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication PPP2CA PPP2CB PPP2R1B PPP2R1A RB1 E2F1 PRIM2 CCNB1 PRIM1 POLA1 POLA2 PPP2R3B TFDP1 CDK1 ORC5 ORC4 TFDP2 ORC6 ORC1 MCM8 ORC3 ORC2 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME ITPA SLC29A3 ADK SLC28A2 SLC29A1 NT5C2 SLC28A3 NME2 PNP ADA NME1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP1A2 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement PSMA5 DOCK1 PSMA6 PSMA3 PSMA4 PSMA1 ARHGEF4 PSMA2 UBA52 PSMD12 PSMD11 RAC1 PSMD14 PSMD13 IL6 TYK2 JAK1 TRAF7 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SRC UBC HACE1 CTNND1 PSMB1 RPS27A ADRM1 CDH1 NFKB1 SEM1 CTNNB1 PSMC5 CBLL1 PSMC6 ELMO1 PSMC3 PSMC4 PSMC1 PSMC2 FARP2 STAT3 TIAM1 CTSL IL6ST RNF19B VAV2 CTSS CTSB JAK2 CTNNA1 JUP CDH11 CDC42 PSMD8 PSMD6 IL6R BIRC2 PSMD7 PSMD2 VCL PSMD3 XIAP PSMD1 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs BTK BAIAP2 ARPC1B ABI2 ARPC1A WASL ABI1 PTK2 WAS RAC1 NCKAP1 ACTG1 NCKIPSD BRK1 CYFIP1 ARPC4 ARPC5 ARPC2 ARPC3 NCK1 ABL1 ACTR3 ACTR2 MAPK1 ACTB CDC42 MAPK3 WASF3 CYFIP2 WIPF1 WIPF2 WIPF3 NCKAP1L WASF1 WASF2 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine ACSM5 ACSM4 GLYAT GLYATL3 ACSM2B GLYATL2 GLYATL1 ACSM2A CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily H2AC6 H2AC7 AXIN2 DKK2 H2AX CHD8 H3-3B H2AC19 H2AC14 H3C8 CHD9 H2BC12L IGF2 H2AJ H2BC26 H2BC21 WDR5 CTNNB1 H3C15 EP300 H2BC17 H2BC12 CHD7 NQO1 H2BC13 NKD2 H2BC14 FAM124B H2BC15 CREBBP H2BC9 CTCF H2BC8 H2BC5 H2BC11 H2BC3 CHD6 H2BC1 H4C9 MAFK NFE2L2 H2AB1 H2AZ2 H2AC20 H2AC8 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion FFAR1 GNA11 GNAQ CD36 GNA14 PLCB3 ACSL4 GNA15 PLCB1 ACSL3 PLCB2 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 UBE2N MYD88 IRF7 IRAK1 UBE2V1 TRAF6 TLR9 TLR7 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) EZH2 H2AX PRKAG1 PRKAG2 ASH2L PRKAG3 CTLA4 TEAD1 TEAD2 TEAD3 H3-3B TEAD4 H3C8 FOS H2AJ YAP1 RRN3 ERCC6 H3C15 RICTOR SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 H2BC1 MBD2 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 BCDIN3D XPO5 DROSHA INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 PRR5 INTS12 GSK3B INTS13 INTS14 DPY30 INTS10 ICE1 ICE2 H2BC26 SSU72 H2BC21 MTREX NABP2 MLST8 NABP1 WDR5 YWHAG ELL2 EED ELL3 PDPK1 ZC3H8 H2BC17 RPRD2 RPAP2 H2BC12 RPRD1B H2BC13 RPRD1A H2BC14 POU2F2 H2BC15 H2BC11 PRKAA1 PRKAA2 LEF1 CAVIN1 RBBP4 RBBP5 RBBP7 TCF7L2 H2AZ2 TCF7L1 DDX21 PTPN11 MTOR TNRC6C TNRC6A TNRC6B CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L ANGPTL4 GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 LPL ELOA2 SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ACTB TP53 PAXIP1 SMARCA5 BAZ1B HCFC1 ARID4B PSIP1 SAP30 SUDS3 SAP30L SAP18 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 PAPOLA SYMPK CXXC1 CPSF4 TGFB1 HSP90AA1 PARP1 ZCCHC8 PABPN1 RBM7 TASOR PPHLN1 RAN CDC73 BLK ELF1 ELF2 CBFB PAX5 SKIC8 RUNX1 CTR9 RTF1 LEO1 PAF1 MTA1 MTA3 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SS18L1 SOX2 ZNF521 TSNAX PRKRA DICER1 TARBP2 TDG TSN TRPC3 PLD6 AGPAT2 ZNF765 ZNF93 ZNF816 ZNF534 PRKCQ ADIPOQ PIWIL2 TDRKH PIWIL1 PIWIL4 DDX4 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 PLIN2 SOX9 YWHAH YWHAZ KIT LIPE HDAC1 DGAT2 POMC UHRF1 FABP4 KDM6A CAV1 TET3 PLIN1 LPIN1 MGLL CGA CPSF7 FURIN RPTOR STK11 DNMT3L SPOCD1 C19orf84 TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NFYA NFYB NFYC GPAM SCD SP1 SSB NFIX NFIA NFIB NFIC CASP1 TP63 CEBPA TNFRSF10B TNFRSF10A ITCH FAS CYCS PDK4 BAX STUB1 OGT PRKACA CAMK2B CAMK2D CAMK2A CAMK2G TFAM EHMT2 TFB2M EHMT1 PAGR1 MAPKAPK5 AJUBA TXN MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 IL6 MDM2 MDM4 BMI1 VENTX RING1 MYBBP1A CCNA2 CCNA1 CEBPB RNF2 CDKN2B CDKN2A BDNF GRIN2B JAG1 DLL1 PHAX SNRPD3 PRMT5 SNRPG SNRPE SNRPF SNRPB RRP8 PHF20 CHEK2 ZNF385A DNMT3B PCBP4 DNMT3A DNMT1 SRRT GRIN2A CAMK4 PLK2 MDC1 SPI1 MT-CO1 RBPJ NOC2L ZNF17 ZNF287 ZNF18 ZNF19 ZNF285 RBFOX1 RBFOX3 ZNF282 ZNF10 ZNF12 ZNF14 CLDN5 SCO2 ZNF705EP DDIT3 DDIT4 TXNIP MT-CO2 MT-CO3 MYL9 ZNF28 ZNF274 ZNF273 MEAF6 ZNF20 GATA4 GATA3 ZNF23 GATA2 GATA1 ZNF25 ZNF26 SFN ZNF268 PPARGC1B ZNF267 PRELID3A ZNF266 ZNF264 ZNF263 ABCA6 NR2F1 ZNF34 NR0B2 NR2F6 COL1A1 COL1A2 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 BBC3 MED12 MED14 SF3B1 MED13 HEY1 CASP10 MED10 ZNF41 HEY2 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 CNOT6L ACTL6B ZNF480 ACTL6A MED27 MED26 SIRT3 DDB2 MED23 MED25 MED24 MMP13 MED20 ZNF479 ZNF235 ZNF234 ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 ZNF470 HTT EGFR BGLAP PLAGL1 SPP1 ZNF227 ZNF468 ZNF226 KAT8 BID PHLDA1 ZNF225 ACSL1 ZNF224 HCFC2 ZNF223 WDR82 ZNF222 PEX11A MBD3 BOD1L1 ZNF221 MBIP ZNF461 TASP1 ZNF460 KAT14 USP9X DR1 ATAD2 BOD1 ZNF77 CIDEC ZNF79 TADA2A GATAD2B ZZZ3 GATAD2A YEATS2 SKI TADA3 ZNF70 AKAP8L ZNF71 SGF29 ELOVL5 ZNF74 PHF20L1 AGRP ZNF699 PLIN4 MTERF1 ZNF215 KANSL1 EZH1 ZNF214 KANSL2 ZNF213 PHF19 KANSL3 ZNF697 EPOP THRSP ZNF696 PNPLA2 PHF1 ZNF212 JARID2 ZNF454 TET2 ZNF211 TET1 ZNF692 MTF2 ZNF691 IPO8 UBE2D3 EZHIP PSMD8 RORC RORB PSMD6 YY1 PSMD7 SESN3 PSMD2 ZNF208 PSMD3 SESN2 PSMD1 ZNF205 ELAC2 ZNF689 ANG KMT5A ZNF688 ZNF446 SKP1 ZNF445 PITX2 PRKCB ZNF202 PSMA5 ZNF443 PSMA6 ZNF200 PSMA3 ZNF684 PSMA4 ZNF442 PSMA1 ZNF441 PSMA2 BNIP3L ZNF682 UBA52 ZNF440 ZNF681 PSMD12 ZNF680 PSMD11 AFF4 ZFP69B MLLT1 PSMD14 FOXP3 MLLT3 PSMD13 NPAS4 SUPT6H CUL1 MAF IWS1 PSMA7 ZNF439 EAF1 ZNF679 EAF2 RELA ZNF678 PSMB6 ZNF436 PSMB7 ZNF677 PSMB4 ZNF676 PSMB5 ZNF433 ZNF675 UBB PSMB2 ZNF432 PSMB3 PVALB ZNF431 UBC PSMB1 ZNF430 RPS27A GRIA2 KMT2D ADRM1 ZNF671 NFKB1 ZNF670 SEM1 CPAP PSMC5 MAX PSMC6 DLX5 PSMC3 DLX6 PSMC4 KMT2B PSMC1 FOXO6 PSMC2 FOXO4 FOXO1 ZNF840P ATXN3 SOCS3 MED30 MOBP ZKSCAN7 HDAC4 ZNF429 MED31 THRB ZKSCAN8 UBE2I ZKSCAN3 VDR SMYD2 NR1H2 RORA ZNF669 ZNF668 NR3C1 ZNF426 NR2C1 ZNF667 ESR1 ZKSCAN5 ZNF425 ZKSCAN4 NR5A1 ZNF665 NR4A2 AR ZNF664 ZKSCAN1 RXRA SOCS4 SUMO1 BCL2L14 ZNF662 SUMO2 ZNF420 RARA ZNF660 PGR PPARG BRPF1 PPARA BRPF3 TNFRSF10C CD36 FBXO32 MRE11 G6PC1 BRCA1 TNFRSF10D RGCC ZNF419 KAT5 ZNF418 EXO1 ZNF417 ZNF658 ZNF416 CHEK1 ZNF415 NBN PIN1 TOPBP1 ZNF655 SUV39H1 SP7 PPP1R13B COX4I1 COX4I2 RFC5 PTEN RFC3 RMI2 ITGAL PPP1R13L RFC4 ZNF649 ATF7IP DGCR8 SETDB1 YAF2 RFC2 RMI1 NKX3-2 ZNF641 TOP3A TRIM63 HUS1 AEBP2 APAF1 ITGA4 TNFRSF18 RAD51D ARNT RABGGTB DNA2 RABGGTA RHNO1 BLM RRM2B HAND2 ZNF875 PCNA ITGA5 SRF PPM1D WRN ZNF627 ZNF626 BRIP1 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 RBBP8 ATRIP E2F5 ZNF620 BARD1 E2F6 E2F7 E2F8 RPA1 ZNF860 RPA2 PTPN1 MGA TBX5 RAD50 PINK1 RAD51 ZNF619 RPA3 SST IL2RA ZNF616 RAD17 SYT10 RAD1 ZNF615 ATM ZNF614 RAD9B ZNF613 ATR ZNF611 RAD9A PTPN4 ANAPC15 ZNF610 ANAPC16 ANAPC7 TRIM33 SMARCB1 UBE2C CCNC UBE2E1 UXT UBE2D1 LGALS3 ZNF729 ANAPC10 TRIM28 ANAPC11 ZNF727 CCNB1 CDC23 ZNF726 ZNF724 UBE2S CDC26 EPC1 CDC27 CCN2 ZNF721 CDC16 SMARCC1 CDK1 ANAPC4 SMARCC2 ANAPC5 ZFP1 ANAPC1 ZFP2 ANAPC2 ZNF718 ZNF717 ZNF716 SRC ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 L3MBTL1 ZNF324B CTNNB1 L3MBTL2 FOXG1 MET TGFA ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 YWHAB APOE PCK1 CRADD IQSEC3 MAPK1 SMARCA2 SMARCA4 MPHOSPH8 SNW1 MAPK3 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C MAPK14 CTSL CTSK HNF4A COX8A MAPK11 SREBF1 COX8C PBRM1 SATB2 COX5B COX5A RXRB ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 COX6C GCK ATF2 VEGFA TTC5 CCNG2 CCNG1 HDAC3 MAMLD1 ZFP28 SMARCD3 PRDM7 PRDM1 COX6A1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 XPO1 GTF3C1 COX6B2 GTF3C2 GEM GTF3C3 COX6B1 CRCP ZNF92 GTF3C4 EP300 GPRIN1 GTF3C5 NDRG1 TBL1X GTF3C6 HIGD1C IRAK1 BRF1 TFAP2A POLR3GL PPARGC1A TFAP2B GTF3A NCOA1 ZFHX3 POLR3A TFAP2C MED1 POLR3B NCOA2 TFAP2D POLR3C CREBBP AUTS2 POLR3D MEF2C TFAP2E POLR1C NCOA6 CNOT10 POLR3E IL2 POLR3F IL3 POLR1D BMP2 NR1D1 POLR3G SIRT1 CNOT11 POLR3H BDP1 TCF3 NCOR1 DYRK2 POLR3K TBL1XR1 LDB1 CARM1 CHD4 CHD3 TRIAP1 BMAL1 PIDD1 YWHAQ MYBL2 TGIF1 ZNF75CP RBM14 TGIF2 CAT TMEM219 RETN NFATC2 AURKA INS CALM1 MTA2 RRM2 YWHAE ZNF804B REST JUN KRAS FASLG ZNF175 SOD2 MAML2 CDC25C MAML1 FOXO3 SERPINE1 GLS NAMPT ZSCAN32 MYB PIP4K2A PRDX2 BCL2L11 PIP4K2B JUNB CDK5 ZNF169 RNF111 GAMT PRDX1 ZNF705G ZNF705D ZNF160 CDK5R1 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 NOTCH1 RBX1 ZNF155 ZNF154 ZNF394 NEDD4L NKX2-5 NR2C2AP NFE2 IHH PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 SETD1B SETD1A CDC7 NR1D2 ZNF37A ZNF702P ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET GPI BTG2 RARG BTG1 SETD9 CRH CHM GLI3 GLI2 ING5 ING2 PIP4P1 AIFM2 TNKS1BP1 RSPO3 ZNF124 ZIK1 BRD2 BRD1 TCF12 NCOR2 KAT2B KAT2A SNAPC5 TAL1 SNAPC1 RARB SNAPC2 ZNF599 SNAPC3 ZNF114 SNAPC4 ZNF143 ZNF597 ZNF596 BRF2 ZNF112 ZNF595 ZNF350 GPS2 ZNF589 ZNF347 BRD7 ZNF587 ZNF586 ZIM2 ZNF343 ZNF101 ZIM3 ZNF584 ZNF100 ZNF583 WWOX ZNF582 PCGF6 TIGAR PCGF5 PCGF2 WWP1 HIPK1 POU2F1 POU4F1 POU4F2 ZNF33B NCOA3 HIPK2 NR5A2 ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 ITGA2B YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 MEN1 ZNF563 IGFBP1 ZNF562 GAD1 ZNF320 GAD2 ZNF561 USP7 ZNF560 IGFBP3 USP2 NRBP1 KAT6A ZNF559 ZNF317 ZNF558 ZNF557 ZNF799 ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 NOTCH2 ZNF793 ZNF551 CSF1R RB1 ZNF792 CDKN1A NOTCH3 CDKN1B ZNF550 CCND3 ZNF791 ZNF790 FZR1 CCND2 NOTCH4 CCND1 ZNF767P E2F1 ZNF549 ZNF548 ABL1 ZNF547 SKP2 DAXX ZNF546 ZNF304 ZNF544 CDK6 ZNF786 TFDP1 CCNE2 ZNF302 ZNF785 TFDP2 LSM10 ZNF543 CDK4 SLBP CCNE1 SKIL LSM11 ZNF300 CDK2 PLXNA4 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC PPP2R1B CNOT4 PPP2R1A CDK8 ZFP69 CNOT6 CNOT7 BCL6 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 ZNF774 CNOT9 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 SIN3A ZNF528 ZNF764 LBR ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 HDAC2 SMARCD2 PPP2R5C RNF34 GLS2 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 BIRC5 ZNF749 ZNF506 ZNF747 ZNF746 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 AURKB KCNIP3 KLF4 PML ZNF738 PPP2CA MCRS1 ZNF737 PPP2CB ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 TP53AIP1 ZNF607 ACSS3 ZNF606 ZNF605 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 CITED1 POLRMT CITED2 CITED4 PRMT6 KRABD5 KRABD4 PRMT1 MSH2 KRABD3 GP1BA PMS2 SGK1 ZNF2 MLH1 MORC2 ZNF3 NPY ARNT2 ZNF354A ZNF354C ZNF354B STEAP3 LMO1 LMO2 TJP1 KCTD1 OCLN ATP1B4 LIFR KCTD6 FANCD2 COXFA4 NOP2 COX7A2 CCNH COX7A1 RNMT PMAIP1 POLR2A SMAD2 POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E CBX5 POLR2F SMURF2 POLR2G CBX3 POLR2H SMURF1 POLR2I SMAD6 POLR2J ESR2 POLR2K SMAD7 POLR2L NR4A1 RNGTT TP53I3 GTF2H1 NR4A3 GTF2H2 JMY SUPT5H KDM5B GTF2H3 THRA GTF2F1 CGB8 GTF2F2 SLC2A3 GTF2H4 NR2E1 GTF2H5 YBX1 CDK7 CASP6 ERCC3 CASP2 ERCC2 AXIN1 MNAT1 OPRM1 ARID1A ARID1B RBL2 H2AC19 RBL1 H2AC14 IFNG H2BC12L ZNF197 AKT2 ZNF195 MYC NR2C2 AKT3 THBS1 HSPD1 AKT1 ERBB2 HES1 PRKAB2 ZNF189 CSNK2A1 ZNF286A CSNK2A2 ZNF184 PRKAB1 ZNF180 CSNK2B TTF1 OPRK1 SAP130 ARID3A UBTF DEK SAP30BP POLR1A MAPKAP1 POLR1B POLR1E POLR1F POLR1G POLR1H BAZ2A TAF1D TAF1B TAF1C TAF1A WWTR1 YES1 H4C9 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 CDKN1A TP53 ZNF385A PCBP4 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease NCBP1 NCBP2 ZMYM2 NRAS STAT1 GAB1 STAT3 HRAS PLCG1 POLR2A FRS2 POLR2B POLR2C TRIM24 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L FGFR2 SOS1 GTF2F1 GTF2F2 FGFR1 FGF1 FGF2 FGF3 CEP43 FGF4 FGF6 FGF7 FGF9 FGF20 STAT5A FGF23 STAT5B FGF22 GAB2 FGF16 FGF18 FGFR3 PIK3CA PIK3R1 FGFR4 FGF10 LRRFIP1 BCR CUX1 FGFR1OP2 MYO18A CPSF6 ERLIN2 BAG4 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade F11 GP1BA PROS1 F5 F8 F10 GP9 FGB GP1BB FGA GP5 GGCX VWF FGG TPST2 TPST1 F2 F9 PROC ANO6 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy ATM USP30 EPAS1 PEX5 UBB NBR1 UBA52 UBC RPS27A SQSTM1 MAP1LC3B SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer MAPK1 MAPK3 PIK3R2 CLIP1 PIK3CA PIK3R1 PIK3CB NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals UNC5A NTN1 UNC5B SRC UNC5C UNC5D PTPN11 DCC MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 RIPK3 PPP2R5D MEF2C TRAF2 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 TP53 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC TUBA4A CCT6A TUBA1C TUBA1A CCT3 CCT2 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBA3D TUBA3C CCT8 ACTB CCT7 CCT5 CCT6B CCT4 TUBB6 TUBB3 TUBB1 TUBB4B TUBB4A AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport ADHFE1 D2HGDH L2HGDH GSTZ1 VDAC1 OXA1L COX7B COX7C COX8A COX8C COX5B COX5A COX6C KGD4 HIGD1A DLD COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C COX19 UQCRB COX17 UQCC3 UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH CS LYRM4 UQCRQ LYRM7 UQCRC1 ACO2 UQCRFS1 UQCRC2 CYC1 MT-CYB FXN NDUFS3 TIMM21 SLC25A18 MDH1 NDUFB8 MDH2 SLC25A12 SLC25A11 SLC25A22 SLC25A13 IDH3G NDUFA5 LETM1 ETFB MT-CO1 NDUFAB1 SCO2 MT-CO2 MT-CO3 SLC25A4 PM20D1 RANBP9 SIRT3 ISCA2 ISCA1 CMC1 PYURF SCO1 TMEM126A SUCLG2 WDR26 SUCLG1 GLO1 GOT1 TMEM126B GPT TRAP1 PDHB LDHC SURF1 NDUFAF8 GOT2 RMND5B LDHB NDUFAF6 LDHA NDUFAF7 NDUFAF4 MAEA NDUFAF5 PDPR COX15 NDUFAF2 RMND5A SFXN4 MPC1 NDUFAF3 MPC2 MT-ND6 PDK4 NDUFAF1 CYCS PDK3 UBA52 HCCS PC MT-ND4 TMEM186 MPC1L MT-ND5 NNT NEK1 MT-ND2 RAB5IF ME3 MT-ND3 DLAT ACAD9 MT-ND1 COQ10B ME2 PDK2 COX7A2L COQ10A PDK1 TMEM177 PDHX SDHAF2 ATP5MC2 SDHAF3 ATP5MC3 PDHA2 SDHAF1 ACAT1 FAHD1 SDHAF4 PDHA1 SIRT4 FH ATP5MC1 ARMC8 MT-ATP6 DMAC1 DMAC2 PDP1 PET117 ATP5F1A MKLN1 UBB ECSIT TIMMDC1 GID4 PET100 PDP2 ATP5F1B NUBPL GID8 UBC LDHAL6A LYRM2 LDHAL6B RPS27A NDUFA13 ATP5MK NDUFA11 ATP5MJ NDUFA12 ATP5MG TACO1 ATP5MF NDUFA10 ATP5ME DMAC2L CSKMT SDHC HSPA9 ATP5PF SDHD ATP5PD SDHA SDHB UCP1 NDUFB10 COX16 ATP5PB NDUFB11 COX18 COX11 ATP5F1C COX14 ATP5F1D NDUFV3 MT-ATP8 NDUFV2 ATP5F1E NDUFV1 COA3 ATP5PO COA1 IDH2 COXFA4 HIGD2A COX20 COX7A2 ETFA COX7A1 TMEM223 IDH3B IDH3A COA5 NDUFC2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 COX4I1 SUCLA2 COX4I2 SLC25A27 UCP3 UCP2 SLC25A14 ME1 OGDH DLST REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PARVB LIMS1 PXN ARHGEF6 TESK1 ACTN1 RSU1 PARVA TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 EREG BTC NRG2 HBEGF NRG3 EGFR NRG4 NRAS HRAS EGF ERBB2 NRG1 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 SSR1 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 SRPRA SRPRB RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 SEC11A RPS5 SEC11C RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 DDOST RPS21 SPCS3 RPS24 SPCS2 RPS23 SPCS1 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A SEC61A2 SEC61A1 SEC61G SEC61B SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RPN2 RPN1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) PPP2CA PPP2CB REST JUNB CDK5 RPS6KA1 FOS NAB1 ATF1 NAB2 SH3GL3 ARC CDK5R1 TRIB1 TPH1 RRAD MEF2A DUSP4 EGR3 DUSP3 EGR4 FOSL1 VRK3 ID2 DUSP6 ID3 DUSP7 SGK1 MAPK7 LYL1 F3 VGF ELK1 ASCL1 CDK5R2 MAPK1 MAPK3 ID1 FOSB MAPK14 MAPK11 DNM2 PPP2R1B PPP2R1A MAPKAPK2 EGR2 TCF12 ATF2 RPS6KA5 EP300 ID4 EGR1 MEF2D SRF PPP2R5D MEF2C RPS6KA3 RPS6KA2 CHD4 JUND RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT MYH9 RHOB RHOC CIT MYL12B PPP1CB CDKN1B PPP1R12A PPP1R12B MYH11 RAC1 KIF14 PRC1 MYH14 MYH10 DLG4 MYL6 RHOA MYL9 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP2E1 CYP2F1 CYP24A1 PTGIS TBXAS1 CYP4F12 CYP8B1 ADH7 ARNT2 POMC CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 RXRA CYP19A1 CYP51A1 CYP26A1 CYP26B1 CYP26C1 FDX1 FDXR FDX2 ARNT CYP11B2 CYP46A1 CYP21A2 CYP39A1 POR CYP2U1 CYP27B1 CYP4F2 CYP11B1 NCOA1 CYP4A11 CYP11A1 CYP4V2 CYP1B1 NCOA2 CYP2R1 NR1H4 CYP7B1 CYP7A1 CYP27A1 CYP2J2 CYP3A43 AHR FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism ALDOB ALDH1A1 TKFC GLYCTK AKR1B1 KHK SORD DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production MYD88 RELA IRF7 DHX9 DHX36 NFKB1 NFKB2 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction KCND2 SCN11A KCND3 GATA4 SCN9A SCN1B SCN1A SCN10A KCNA5 SCN8A KCNJ14 SCN3B SCN3A KCNK6 KCNK2 KCNK7 KCNK1 KCNK3 KCNK4 SCN2A SCN2B SCN5A SCN4A SCN4B SCN7A CACNA2D2 CACNA1C CACNG6 NPPA FGF14 RANGRF FGF13 FGF12 FGF11 CACNB1 CACNB2 CACNG8 NPR1 NPR2 NPPC KCNJ2 CACNG4 CORIN KCNJ4 KCNJ12 KCNIP3 CALM1 NKX2-5 KCNK5 KCNK12 KCNK15 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 AKAP9 RYR3 SLC8A2 SLN NOS1 CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 KCNE1 ATP1B1 KCNE2 KCNE3 TRDN KCNE4 ASPH STIM1 KCNE5 ORAI2 ORAI1 KAT2B CAMK2B CAMK2D CAMK2A MME ATP1A4 ITPR1 ATP1A3 CES1 ITPR2 ATP1A2 ITPR3 ATP1A1 SRI PLN TNNI3 CACNG7 CAMK2G KCNJ11 DMPK ATP2B4 ATP2B3 ATP2B2 KCNH2 ATP2B1 SLC8A3 FXYD4 FXYD3 FXYD2 KCNK10 FXYD1 KCNIP1 KCNIP2 FKBP1B FXYD7 KCNIP4 KCNK13 FXYD6 KCNK16 KCNK17 KCNK18 KCNQ1 HIPK1 WWTR1 HIPK2 TRPC1 TBX5 KCNK9 KCND1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors FFAR1 GPR31 FFAR4 FFAR3 FFAR2 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 NTF4 PLCG1 NTRK2 BDNF POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events PRKAG1 CALM1 PRKAG2 PRKACG PRKAG3 PRKACB RAC1 RPS6KA1 SRC GRIA2 NRAS MAPK1 HRAS GRIN2B MAPK3 RPS6KA6 KPNA2 PRKAR1B GRIA1 PRKAR2B PRKACA PRKX RASGRF2 CAMK2B ADCY1 RASGRF1 ACTN2 CAMK2D ADCY8 CAMK2A GRIN2C NRGN PRKAR2A GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 PRKAR1A CAMK4 NEFL NRG1 CAMK1 PRKAB2 CAMK2G PRKAB1 CAMKK1 CAMKK2 PDPK1 GIT1 PRKAA1 RPS6KA3 PRKAA2 RPS6KA2 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants HSP90AA1 CDC37 ERBIN ERBB2 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins UBA52 TSG101 NMT2 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 UBB VPS28 UBC RPS27A ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors ADCYAP1R1 NTRK1 NGF NTRK2 ADCYAP1 ADORA2A NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development WT1 LHX1 JAG1 LFNG HNF1B DLL1 IRX1 IRX2 WNT9B POU3F3 HNF4A WNT4 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 NOTCH3 PSENEN PSEN2 PSEN1 APH1A YBX1 NCSTN APH1B ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAG1 PRKAG2 CAB39L RPTOR STK11 PRKAG3 STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD CAB39 SLC38A9 RHEB LAMTOR2 PRKAB2 LAMTOR1 LAMTOR4 MLST8 LAMTOR3 PRKAB1 LAMTOR5 PRKAA1 PRKAA2 MTOR NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway HDAC10 HDAC11 MAML2 MAML1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 NOTCH1 NOTCH2 TBL1X NOTCH3 RBPJ HDAC5 HDAC1 HDAC2 NOTCH4 CREBBP HDAC4 HDAC8 HDAC9 HDAC6 NCOR1 HDAC7 TBL1XR1 SNW1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 SSB GTF3C2 NFIX GTF3C3 NFIA CRCP NFIB GTF3C4 NFIC GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules MAGT1 STEAP4 TFRC RHCG RHBG HFE SLC40A1 TCIRG1 HEPH SLC22A17 FTH1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 DERL3 ATP6V0E1 DERL1 ATP6V1G2 DERL2 SLC5A8 GLRX3 ABCB7 ATP6AP1 SLC11A2 TFR2 OS9 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 FTL PLEKHA8 ABCG2 ATP6V1B1 ATP6V1A IREB2 NEDD8 CAND1 FTMT ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 TUSC3 ATP6V1F ATP6V1C2 ATP6V0A1 CYBRD1 CP TF LCN2 ACO1 VCP SLC9A2 SLC9A3 SEL1L SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 RNF185 STOM SLC2A8 RNF5 ERLEC1 AQP9 AQP7 HDLBP PCSK9 SLC25A18 AP2A1 EIF2S3 LIPA AP2A2 LIPC EIF2S2 CREB3L3 SLC25A11 EIF2S1 PRKACG SLC25A22 LIPG LDLRAP1 PRKACB AP2M1 MYLIP SLC35A3 CUBN AMN SLC43A2 APOA2 SLC1A1 SLC2A9 APOA4 SLC43A1 SLC1A2 LSR APOA5 RSC1A1 SLC3A1 NPC1 SLC1A3 SLC2A2 SLC5A1 SOAT1 SLC1A4 SOAT2 SLC3A2 SLC6A3 NPC2 SLC1A5 ANGPTL8 SLC7A11 ANGPTL3 SLC1A6 ANGPTL4 SLC6A20 SLC7A10 LPA CES3 SLC1A7 ABCD1 SLC7A1 ABCG1 SLC7A3 CETP SLC25A29 MTTP SLC38A3 SLC67A1 LCAT SLC36A4 LPL SLC38A2 LMF2 SLC38A5 LMF1 AP2S1 SLC38A4 SLC36A1 APOF SLC6A19 A2M LDLR SLC38A1 GPIHBP1 SLC36A2 SLC6A15 FGF21 ABCA1 SLC6A14 APOC4 SLC6A12 SLC16A10 NR1H3 SLC6A6 APOBR SLC7A5 APOC3 SLC7A6 AP2B1 SLC7A7 NCEH1 SLC7A8 APOC2 SLC7A9 APOC1 ALB P4HB SLC35B3 SLC35B2 ZDHHC8 ADCY9 PRKAR1B PRKAR2B ADCY4 ARL2 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SLC35D2 FBXL5 SLC47A2 SLC22A4 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 PEX19 SLC22A16 SLC17A5 ABCA6 SLC25A5 SLC25A4 SLC25A6 SLC2A13 SLC5A11 ADD1 SLC5A3 ADD3 SLC26A11 SLC35D1 SLC26A2 SLC26A1 ABCA12 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 ABCB6 ABCB4 SLC5A2 SLCO1B1 SLCO1B3 SLC33A1 SLC6A5 SLC26A4 SLC26A3 SLC12A2 SLC6A2 SLC12A3 SLC12A4 SLC22A12 SLC2A10 SLC12A5 SLC2A1 SLC12A1 ABCC6 SLC12A6 CYGB SLC29A3 SLC12A7 SLC24A4 SLC20A2 SLC35A2 SLC16A1 SLC24A5 CLTC CLTA SLC4A7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SLC25A10 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 SLC24A1 PSMB6 PSMB7 RUNX1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SLC5A6 SLC6A7 ADRM1 SLC6A9 SLC17A6 SEM1 PSMC5 PDZD11 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SLC15A1 CTNS SLC15A3 SLC15A4 NR1H2 ABCC1 ABCG8 ABCG5 CLCN6 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 ATP11C ATP11B PRKAR1A ATP11A SLC9B1 SLC22A3 ABCB1 SLC9B2 SCNN1G SCNN1D AQP8 SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA TRPM1 NALCN TRPM2 ASIC4 TRPM7 ASIC5 CLCA2 TRPM8 CLCA1 TRPM5 SLC4A2 TRPM6 ASIC2 SLC4A3 TRPM3 ASIC3 SLC4A5 CLCA4 TRPM4 SLC5A9 TRPC7 ASIC1 SLC60A2 ATP8B4 MCOLN3 SLC30A10 ATP8B3 TRPC5 SLC5A4 ATP8B2 TRPC6 ARL2BP ATP8B1 TRPC3 SLC2A14 TRPA1 ATP4B SLC2A11 TRPC4 ATP4A ABCC3 SLC2A12 TRPC1 WNK1 NIPA1 WNK2 TRPV2 SLC39A10 WNK3 TRPV3 NIPA2 CUTC TRPV1 SLC39A14 UNC80 MCOLN1 SLCO4A1 ATP7B MCOLN2 SLC29A4 ATP7A TRPC4AP SLC17A1 TSC22D3 TRPV6 DMTN ANO8 TRPV4 SLCO4C1 ANO9 TRPV5 SLC28A1 ANO6 SLC27A1 ANO7 SLCO2B1 ANO4 SLC39A6 ANO5 SLC39A5 ANO2 SLC39A8 ANO3 SLC39A7 ANO1 SLC16A2 SGK3 SLC39A2 SGK2 SLC39A1 STOML3 SLC39A3 ATP10D SLC27A6 ATP10B LCN9 ATP10A SLC4A10 ATP2C2 PIP CLCN3 LCN1 ATP2C1 SLC26A7 CLCN2 SLC26A9 CLCN1 SLC26A6 BSND ANO10 SLC25A1 MB ATP9B SLC17A3 SLC13A1 SLC13A2 ATP9A SLC13A3 ATP13A1 SLC13A4 TPCN2 NGB TPCN1 SLCO1C1 CLCN7 SLC5A12 CLCN5 SLC5A10 STOML2 CLCN4 OSTM1 LRRC8C MCUB LRRC8D SPG7 ATP13A4 PHB2 LRRC8A ATP13A5 MAIP1 LRRC8B ATP13A2 SLC8B1 SLC13A5 UNC79 LRRC8E PARL GLTP AKAP1 AHCYL2 AFG3L2 SMDT1 SLC35B4 AQP6 VDAC3 AQP4 VDAC2 YME1L1 AQP5 PMPCB AQP2 PMPCA AQP3 NIPAL4 MICU3 NIPAL1 VDAC1 NIPAL2 MICU2 NIPAL3 MICU1 MCU SLC11A1 APOE AZGP1 MIP SLC22A6 SLC45A3 ANKH LCN15 LCN12 RAB11FIP2 MYO5B MRS2 SLC22A11 SLC20A1 SLC66A1 SLC31A1 ESYT3 ESYT2 SLC30A3 SLC30A2 MMGT1 SLC30A1 SLC41A2 SLC41A1 AQP10 SLC2A6 SLC2A7 AQP12A CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 AQP11 SLC46A1 RAB11A HBB HMOX1 APOB SLC2A4 APOA1 HBA2 SLC16A7 SLC16A8 CFTR EMB SLC16A3 CALM1 SLC24A2 LETM1 SLC24A3 SLC44A5 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 ESYT1 SLC44A2 NEDD4L ABCD2 ABCD3 ABCC10 ABCC11 ABCA10 PEX3 GNGT1 ABCG4 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 GNGT2 ABCA5 ABCA4 ABCA9 ABCA7 ABCA8 ABCB10 SLC5A5 ABCC4 ABCA3 ABCC5 GNG10 PRKAR2A GNG3 CYB5R2 CYB5R1 SLC28A2 GNG2 SLC29A1 CA1 CYB5R4 GNG5 CA2 GNG4 SLC29A2 CA4 GNG7 SLC4A1 SLC28A3 GNG8 CYB5RL RHAG AQP1 WWP1 GNG12 GNG11 GNG13 APOD GNB2 GNB1 GNAS GNB4 GNB3 GNB5 SLC35C1 FURIN PCSK6 PCSK5 SLC35A1 SLC34A3 SLC34A2 SLC34A1 ARF1 SAR1B MBTPS1 SLC6A13 SLC6A11 SLC22A2 SLC22A1 SLC6A1 SLC6A4 MBTPS2 SLC32A1 SLC17A7 ABCC2 SLCO1A2 SLC22A8 SLC22A5 VLDLR SGK1 AVPR2 AVP STEAP3 RYR1 RYR2 SLC17A8 ATP2A3 ATP2A2 ATP2A1 SLC8A1 RYR3 SLC8A2 SLN CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 SLC2A3 TRDN ASPH CAMK2B CAMK2D SLC30A8 CAMK2A ATP1A4 SLC30A5 ATP1A3 ATP1A2 ATP1A1 SRI PLN CAMK2G KCNJ11 ATP2B4 ATP2B3 ATP2B2 ATP2B1 PHB1 SLC8A3 FXYD4 FXYD3 FXYD2 FXYD1 FKBP1B FXYD7 FXYD6 ERLIN1 RAF1 ERLIN2 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases H2AX RAC1 MTMR1 H3-3B TFRC H3C8 VAV1 H2AJ SCFD1 H3C15 ATP6AP1 PAK1 PAK3 PAK2 KLC1 KLC4 H2BC9 KLC3 H2BC8 KLC2 H2BC5 DOCK3 H2BC3 FRS3 H2BC1 TIAM1 HMOX2 H2AB1 H2AC8 H2AC6 H2AC7 JAG1 VCP ITSN2 DBT RTKN SOWAHC ARHGEF10L STK10 AKAP13 SLK H2BC26 H2BC21 ARHGEF11 ARHGEF10 NCKAP1 ARHGEF12 NCF1 YWHAG ARHGEF17 STARD8 NCF2 NCF4 RHOB PDPK1 CIT SNAP23 H2BC17 DAAM1 BRK1 ARHGAP6 ARHGEF3 H2BC12 ARHGEF1 DOCK10 H2BC13 ARHGEF2 SYDE1 H2BC14 PKN3 ARHGAP42 H2BC15 PIK3CA BAIAP2L1 ARHGEF25 PICALM RAC3 ARHGEF28 IQGAP3 LCK GIT1 SWAP70 STOM RHPN2 ARAP2 H2BC11 CYBB ECT2 STARD13 ARAP3 JUP OCRL CAVIN1 CYBA BCR CDC42 PCDH7 AMIGO2 MYO9A NET1 CTTN NOXO1 ANLN ARHGAP17 ARHGAP15 DIAPH1 ABR CSK ACTC1 RACGAP1 DLC1 PKN2 SLITRK3 PKN1 NHS H2AZ2 TNFAIP1 SLITRK5 RND3 NCKAP1L CKB WASF1 SEMA4F WASF2 ARHGEF40 CKAP4 NISCH PLEKHG2 IL32 KCTD13 GIT2 ARHGEF15 PLEKHG5 TRIP10 ARHGAP26 BAIAP2 ARHGEF19 TAOK3 RHOC ABI2 TIAM2 OBSCN NOXA1 ABI1 ARHGEF4 NOX3 ARHGEF7 NGEF NOX1 FERMT2 ARHGEF6 FGD1 C1QBP FGD2 GNA13 FGD3 FGD4 ARHGEF39 PLXNB1 SLC1A5 KLK3 KLK2 KDM4C RHOU GJA1 ACTB PTK2B CYFIP2 WIPF1 SCAI WIPF2 WDR91 WIPF3 ANKFY1 WDR81 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 BTK GMIP CDC42EP5 CDC42EP4 CDC42EP3 ARPC1B CDC42EP2 ARPC1A FGD5 CFL1 CHN2 WASL CHN1 FARP1 DEF6 WDR11 VMA22 WAS SHKBP1 GOPC ROPN1 FILIP1 TAX1BP3 FAM13B NF2 CCT6A FAM13A PRC1 POTEE GOLGA8R RALGAPA1 FAM91A1 TEX2 ARMCX3 DDRGK1 TUBA1B NSFL1C ARHGAP11A ZNF512B ARHGAP11B TAGAP CCT2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 MYH9 ARFGAP2 BLTP3B NCKIPSD DVL1 SH3BP1 DVL2 WHAMM DVL3 GOLGA3 BAIAP2L2 SPATA13 ARPC4 TMEM87A ARPC5 FAF2 ARPC2 AKAP12 ARPC3 HINT2 CTNNA1 GRB7 SH3PXD2A STMN2 RHOH ACTR3 KIF14 RHOF ACTR2 RHOD RND1 STIP1 RHOV EPSTI1 PLEKHG4B WDR6 EMC3 CCT7 PLXNA1 PRAG1 PLXND1 WASF3 SYDE2 FAM83B ANKRD26 ARHGAP44 DST DOCK11 RRAS2 BCAP31 ARHGAP40 BASP1 ALDH3A2 TMEM59 RALBP1 CCDC88A KCTD3 PREX2 MYL9 FAM135A ARHGAP45 VANGL2 ARHGAP19 ARHGAP18 UBXN11 AAAS TOR1AIP1 DLG5 CPD ARHGAP12 WWP2 PKP4 ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 SFN ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 LIN7B RASGRF2 USP9X ARHGEF9 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 FMNL3 HSP90AA1 PRKCB ARHGAP39 SRGAP3 LIMK2 SRGAP2 LIMK1 SRGAP1 MYH14 MYH10 DOCK7 MRTFA SENP1 SRRM1 PTPN13 AR DDX39B PRKCA PIN1 CCP110 CEP97 ARHGAP10 SRF PLK1 SRC STAM CDH1 HGS CTNNB1 STAM2 YWHAB FARP2 MAPK1 PLD2 MAPK3 KIDINS220 FRS2 MAPK14 MAPK11 RAPGEF1 SOS1 PARD6B ARHGEF18 PRKCZ RHOA PARD6A XPO1 PGRMC2 ARL13B DDX4 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO NCOA2 ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L CFTR ARHGDIB EMD TMPO PLEKHG3 YWHAQ ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 CALM1 ARHGEF5 RAB7A EPHA2 YWHAE VAMP3 ARHGEF26 PPP1R12A GARRE1 SHMT2 PPP1R12B CDC25C PPP1R14A PLD1 IQGAP2 KALRN ARHGAP21 LMAN1 LMNB1 STX5 YKT6 PAK4 NDUFA5 MCF2 MCAM ERBIN YWHAH HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 YWHAZ PPP1CB ABCD3 RAC2 S100A9 S100A8 CAV1 VAV3 PTK2 PFN1 VAV2 FLNA PFN2 UACA HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 PAK6 MSI2 PAK5 RHOBTB1 MYO9B ACTG1 RHOBTB2 TRA2B MYO6 ABL2 STK38 RBBP6 RNF20 SPEN CPSF7 KDM1A TMOD3 NCK2 ACTN1 NCK1 TXNL1 COPS4 COPS2 EVL CDC37 PHIP SOS2 PDE5A VIM HNRNPC RBMX DBN1 CUL3 RASAL2 MEN1 SPTBN1 LAMTOR1 MYLK MYL12B CDKN1B SPTAN1 MYH11 ABL1 TPM4 TPM3 MYL6 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MTR MAD1L1 CDCA8 MUC13 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 DLG4 PIK3R4 RCC2 NDC80 ZWINT LBR KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 FLOT1 NDEL1 SEC13 NUDC FLOT2 NUP133 PIK3C3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SAMM50 SPC24 MAD2L1 CENPS NUP37 SPC25 MTX1 SH3RF1 STEAP3 DSP DSG1 DSG2 CAPZB TJP2 PRKCD KIF5B KIF5A H2AC19 H2AC14 H2BC12L PIK3R3 IQGAP1 PIK3R2 PIK3R1 H4C9 ZAP70 MAP3K11 H2AC20 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling NTRK3 NTF3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis NRIP1 NR1H2 FASN RXRB ANGPTL3 RXRA NR1H3 SCD SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 VAMP3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 HLA-B SEC22B PSMA7 MYD88 HLA-A B2M PSMB6 PSMB7 PSMB4 PSMB5 UBB CD14 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSME1 PSME2 SEM1 PSMC5 PSMC6 PSMB10 PSMC3 PSMC4 PSMC1 PSMB8 PSMC2 PSMB9 TAP2 S100A9 TAP1 S100A8 SEC61A2 SEC61A1 SEC61G SEC61B TAPBP STX4 BTK VAMP8 S100A1 CD36 TIRAP HLA-H HLA-C HLA-F LY96 HLA-G HLA-E HMGB1 TLR1 SNAP23 TLR6 CALR TLR2 PDIA3 FGB FGA FGG PSMD8 IKBKB TLR4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) NTRK3 SOS1 BAX PIK3R1 PIK3CA NELFB NRAS PTPRS PTPRO HRAS NTF3 IRS1 PLCG1 SRC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins PRKAR2B PRKACA PRKACG ADCY4 PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A RAB11A ADCY5 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1A AQP1 AQP4 AVPR2 AQP2 AQP3 AVP GNGT1 GNGT2 GNG12 GNG11 GNG13 RAB11FIP2 GNB2 MYO5B GNB1 GNAS GNB4 GNB3 GNB5 ADCY9 PRKAR1B CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes ATF4 ATF6 CALR DDIT3 NFYA NFYB NFYC HSPA5 HSP90B1 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints MCM6 RAD1 ATM MCM2 RAD9B ATR H2AX RAD9A SFN CCNB1 CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 H2BC9 H3-4 YWHAB H2BC8 H2BC5 H2BC3 H2BC1 CDK2 CDC6 CCNB2 H2BC26 H2BC21 UBE2N YWHAG H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 YWHAQ PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 HERC2 YWHAE PSMA4 PSMA1 PSMA2 UBA52 CHEK2 GTSE1 CDC25C PSMD12 PSMD11 CDC25A PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 YWHAH PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 MCM10 YWHAZ PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PKMYT1 PIAS4 WEE1 CDC7 BRCC3 CLSPN TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 UBE2V2 TOP3A HUS1 DNA2 MDC1 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 CDC45 MCM7 RAD50 RPA3 MCM3 MCM4 RAD17 MCM5 MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy TBK1 TOMM40 UBE2V1 UBA52 MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN UBC RPS27A TOMM70 CSNK2A1 CSNK2A2 TOMM20 UBE2L3 TOMM22 CSNK2B UBE2N MAP1LC3A FUNDC1 MTERF3 ATG9A VDAC3 ATG12 VDAC2 ATG5 VDAC1 UBE2D2 SQSTM1 UBE2D3 PRKN PINK1 ULK1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling UBE2D1 RAC1 FOS VAV1 MAPK9 MAPK8 PAK1 PAK2 MAPK10 UBE2D2 IGHV3-23 NRAS IGLV IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 HRAS IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 GRAP2 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ SOS1 UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 FCER1A IGLV1-47 IGLV6-57 MS4A2 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 PDPK1 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 TXK IGKV3D-20 V5-6 FYN TRAF6 IGHE PPP3CA IGLV3-19 PPP3CB IGKV2-30 IGHV2-70 RASGRP1 IGHV2-5 IGLV3-1 PPP3R1 IGHV3-48 NFATC3 IGLV3-25 NFATC2 IGLV3-27 NFATC1 IGKC IGLV3-21 CALM1 FCER1G IGKV1-39 IGKV1-33 V4-6 IGHV3-53 JUN V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 BTK PLCG2 VAV3 SYK VAV2 GAB2 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TEC MAP3K1 AHCYL1 ITPR1 ITPR2 ITPR3 PIK3R2 PIK3R1 LYN MAP2K4 ITK LCP2 LAT2 MAP2K7 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint CDK1 CCNB2 CCNA2 PKMYT1 CCNA1 WEE1 CCNB1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 TP53 PSMD12 PSMD11 COP1 PSMD14 PSMD13 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins VKORC1L1 PLB1 LRP1 LRP8 UBIAD1 APOM AKR1C3 GPC1 HSPG2 GPC3 GPC2 BCO2 APOA2 SDC4 APOA4 SDC2 RDH11 GPC5 BCO1 SDC3 GPC4 LRP10 GPC6 AKR1B10 LRP12 AGRN LPL TTPA APOB SDC1 LDLR LRAT GPIHBP1 APOE APOA1 APOC3 AKR1C1 APOC2 TTR AKR1C4 RBP4 LRP2 RBP2 VKORC1 CLPS RBP1 RETSAT PNLIP SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 SOS1 PRKCE UBA52 STUB1 MEMO1 PRKCD PRKCA NRG2 NRG3 EGFR NRG4 ERBIN AKT2 UBB AKT3 RHOA SRC UBC ERBB2 AKT1 RNF41 NRG1 RPS27A CUL5 USP8 MATK PTK6 EREG PIK3R1 BTC PIK3CA SHC1 HBEGF GRB7 NRAS HSP90AA1 GAB1 CDC37 HRAS YES1 PLCG1 FYN PTPN18 EGF DIAPH1 PTPN12 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation DDX46 DDX42 RBM17 SMNDC1 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 PHF5A SNRPN CHERP PTBP1 SNRPA1 DNAJC8 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 TCERG1 SRRM2 SNRPG SNRPC SRSF8 SNRPA SNRPE HTATSF1 CPSF4 RBM25 PPP1R10 SNRPF SNRNP70 PRPF40A SNRPB TUT1 PPP1R8 SRSF10 SRSF12 RBM39 HNRNPH1 HNRNPH2 RBM5 PABPN1 PAPOLG UBA52 NCBP1 NCBP2 UBB UBC RPS27A FIP1L1 PPP1CB HNRNPU PPP1CA CDC40 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SRSF9 XRN2 GTF2F1 GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 SRSF11 SRRT FUS HNRNPA1 HNRNPA3 TRA2B RBBP6 CCAR1 PCBP1 CPSF7 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC RBMX DHX9 HNRNPA2B1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense PIM1 GBP1 CASP1 SFN INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation EEF2KMT EEF2 RPS2 CALM1 VCP CAMKMT KIN ETFBKMT PRMT3 ETFB METTL22 METTL21A VCPKMT EEF1AKMT2 HSPA8 EEF1A1 EEF1AKMT1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAL ADCY4 ADCY3 ADCY9 ADCY2 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis DHRS7B GNPAT AGPS MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors PPARG MEF2C RBFOX1 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling AKT2 PDE3B THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome NLRP1 BCL2 BCL2L1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin MCM6 MCM2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 ORC5 PSMB7 ORC4 PSMB4 ORC6 PSMB5 ORC1 UBB MCM8 PSMB2 CCNA2 PSMB3 ORC3 CCNA1 ORC2 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SKP2 CDK2 CDC6 PSMD8 PSMD6 PSMD7 PSMD2 MCM7 PSMD3 PSMD1 MCM3 MCM4 SKP1 MCM5 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance CEP83 DYNLRB2 DYNLRB1 IFT25 CEP89 PRKAG1 CEP57 PRKAG2 ARF4 C2CD3 CETN2 PLK1 CEP164 PKD2 PRKAG3 PKD1 IFT52 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CNGA2 BBS9 CDK1 CNGA4 BBS7 TNPO1 IFT57 CEP290 NINL IFT56 BBS5 CC2D2A BBS4 RAB8A OFD1 DYNLT5 IQCB1 MKKS EXOC8 DYNLT2 IFT140 EXOC7 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 RP2 BBS12 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 MAPK14 EXOC5 NEK2 IFT46 MAPK12 SFI1 EXOC2 MAPK11 SDCCAG8 EXOC1 IFT70B IFT70A DCTN2 SSNA1 DCTN3 DYNLT2B ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 ATF2 CEP152 WDR19 CRTC2 GBF1 CSNK1E HDAC3 SCLT1 RAB11A CRTC3 ATAT1 SMARCD3 NEDD1 CRTC1 TTC8 CHD9 ALMS1 TRIP11 CEP162 B9D1 HELZ2 CEP41 CEP43 CLUAP1 TGS1 YWHAG ARL13B INPP5E GLUD1 TBL1X GLUD2 PDE6D GABPA SIRT5 MEF2D PPARGC1A PPRC1 NCOA1 PERM1 MED1 NCOA2 CREBBP MEF2C NCOA6 NR1D1 PRKAA2 NCOR1 TBL1XR1 CARM1 CALM1 YWHAE SOD2 SMO PRKAR2B TUBA4A TUBA1A CAMK4 CCT3 CCT2 HCFC1 TCP1 TFB1M CCT8 CCT5 CCT4 TUBB4B TUBB4A PPARGC1B SIRT3 ESRRA PPP2R1A KIF17 MTERF1 DYNLL1 HSP90AA1 CKAP5 DYNLL2 HDAC6 MAPRE1 PAFAH1B1 DYNC1I2 ALAS1 CLASP1 CYCS DYNC1H1 NDE1 ATP5MC2 ATP5MC3 MICOS13 RHO MICOS10 SIRT4 ATP5MC1 MT-ATP6 B9D2 APOO CNGB1 ATP5F1A CHCHD3 SAMM50 ATP5F1B POLRMT CHCHD6 POLG2 ACSS2 ATP5MK ATP5MJ ATP5MG ATP5MF CPAP ATP5ME DMAC2L TWNK HSPA9 ATP5PF ATP5PD MTX1 APOOL SSBP1 MTX2 ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D MT-ATP8 ATP5F1E TMEM11 ATP5PO IDH2 RXRA AKAP9 PPARA PRKACA DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CCP110 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CEP131 CSNK1D IFT80 CYS1 RPGRIP1L LZTFL1 PRKAB2 IFT88 IFT81 UNC119B PRKAB1 ARL6 ARL3 FBF1 MCHR1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B CEP70 NPHP1 TFAM CEP72 TFB2M NPHP3 CEP192 NPHP4 KIF3C MARK4 CEP76 RAB11FIP3 CEP78 PLK4 BBS2 BBS1 ODF2 RAB3IP IFT122 BBIP1 IFT20 AHI1 IFT22 MKS1 NRF1 IFT27 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization LAMB3 EZH2 H2AX CDH4 LAMA3 LAMC2 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B CLDN2 H3C8 MTBP ZC3H12A CSNK2A3 CLDN6 H2AJ CLDN4 CLDN3 SRC CLDN9 CTNND1 CLDN8 CLDN7 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 CLDN22 CLDN20 ZMYM2 CLDN23 RACK1 CLDN11 CLDN10 CLDN15 CLDN14 SUZ12 CLDN12 H2BC9 CLDN19 H2BC8 CLDN18 H2BC5 CLDN17 CLDN16 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST SDK1 H2AC8 SDK2 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 PARD6G PARD6B MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 PXN PATJ F11R COL17A1 PALS1 ZEB1 CRB3 PARD6A PARD3 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 ITGB1 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 RBBP7 H2AZ2 TGIF2 TNRC6C DOCK1 TNRC6A TNRC6B ARHGEF4 FERMT2 ARHGEF6 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PRKCSH SNAI2 GANAB CD151 MOGS TCF12 VAV2 FLNA VASP PRDM8 BHLHE22 KDM1A CDH8 ACTN1 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 CLDN5 SNAI1 DST TESK1 ZNF217 RSU1 PARVA PARVB FLNC LIMS2 FURIN PCSK6 LIMS1 FBLIM1 ANK3 ILK TYK2 PLEC RB1 POMT2 DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 ITGB4 ITGA6 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PRKCI PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CLDN1 RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 JAK2 H4C9 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism SUMO2 UBE2I VDR CYP27B1 CYP24A1 LRP2 GC LDLRAP1 LGMN PIAS4 CUBN CYP2R1 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs NEIL3 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions PTPN6 TYROBP PTK2B CD47 FYB1 SIRPG SIRPA PTK2 SIRPB1 PTPN11 SKAP2 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations B3GALNT2 POMT1 POMK POMGNT2 DAG1 POMT2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 EIF4E EIF4B EIF4G1 EIF4A2 EIF4A1 EIF4A3 CNOT6L CNOT4 CNOT6 CNOT7 HBS1L TNKS1BP1 NT5C3B CNOT1 SKIC3 CNOT2 DCPS CNOT3 CNOT8 DDX6 LSM1 CNOT9 LSM5 LSM4 LSM3 PATL1 EDC3 LSM2 EDC4 LSM7 TUT7 PABPC1 LSM6 XRN1 TUT4 DCP1A DCP2 DCP1B SKIC2 PAIP1 PAN2 PAN3 CNOT10 CNOT11 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors ADCYAP1R1 GIPR GHRHR GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GLP1R VIPR1 VIPR2 SCT GCGR GNGT1 SCTR GNGT2 GCG GNG12 GNG11 GNG13 GNB2 GLP2R GHRH GNB1 GNAS GNB4 GNB3 GIP GNB5 ADCYAP1 VIP DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage APRT DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 GFPT1 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID CHUK NFKBIA RELA IKBKB IKBKG NFKB1 NFKB2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 DNA2 RHNO1 BLM WRN BRIP1 RBBP8 ATRIP BARD1 RPA1 RPA2 RAD50 RAD51 RPA3 RAD17 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR EIF2AK2 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription EZH2 H2AX H3-3B TWIST2 TWIST1 H3C8 H2AJ H3C15 ZMYM2 HDAC1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 H2BC1 SMARCA4 MPHOSPH8 MAPK3 FOXQ1 SNAI2 H2AB1 TLE1 ZBTB33 H2AC8 H2AC6 PKM H2AC7 MCRIP1 TCF12 H2AC19 H2AC14 H2BC12L ZEB2 ZEB1 H2BC26 H2BC21 CTBP2 CTBP1 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 KDM1A HDAC2 H2BC11 SIRT1 TCF3 H4C9 SNAI1 RBBP4 RBBP7 H2AZ2 H2AC20 KMT5A ZNF217 TGIF2 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PPP2R1B PPP2R1A PFKFB1 PPP2R5D MLXIPL RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib HSP90AA1 CDC37 ERBIN ERBB2 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2AX MTA2 H3-3B TBP H3C8 MYBBP1A H2AJ ERCC6 H3C15 MTA1 HDAC1 SF3B1 MTA3 H2BC9 H2BC8 H2BC5 H2BC3 ACTB H2BC1 H2AB1 POLR2E POLR2F CBX3 H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L KAT2B KAT2A H2AC19 H2AC14 H2BC12L GSK3B SMARCA5 MBD3 H2BC26 H2BC21 BAZ1B TTF1 EP300 GATAD2B DEK GATAD2A H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 EHMT2 POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 DDX21 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing NTHL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ELMO2 DOCK1 ELMO1 PTK6 RASA1 CRK RAC1 ARHGAP35 NRAS HRAS PXN RHOA BCAR1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors P2RY10 LPAR6 P2RY2 P2RY11 P2RY4 P2RY1 P2RY12 LPAR4 P2RY13 GPR17 P2RY14 P2RY6 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis AKR1B1 SORD SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport SLC27A1 SLCO2B1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC16A2 SLC39A2 SLC39A1 SLC39A3 SLC27A6 LCN9 SLC4A10 LCN1 SLC26A7 SLC26A9 SLC26A6 SLC25A1 SLC13A1 SLC13A2 SLC40A1 SLC13A3 SLC13A4 HEPH SLCO1C1 SLC5A12 SLC5A10 SLC8B1 SLC13A5 SLC5A8 AHCYL2 SLC11A2 SLC35B4 SLC11A1 SLC22A6 SLC45A3 LCN15 LCN12 SLC22A11 SLC20A1 SLC31A1 CP SLC30A3 SLC30A2 SLC30A1 SLC41A2 SLC41A1 SLC2A6 SLC9A2 SLC2A7 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC50A1 SLC9A8 SLC4A8 SLC9A9 SLC4A9 SLC9A1 SLC2A4 SLC2A8 SLC16A7 SLC16A8 EMB SLC16A3 CALM1 SLC25A18 SLC25A11 SLC25A22 SLC35A3 SLC43A2 SLC1A1 SLC2A9 SLC43A1 SLC1A2 RSC1A1 SLC3A1 SLC1A3 SLC2A2 SLC5A1 SLC1A4 SLC3A2 SLC6A3 SLC1A5 SLC7A11 SLC24A2 SLC44A5 SLC1A6 SLC24A3 SLC5A7 SLC6A20 SLC10A6 SLC7A10 SLC44A3 SLC1A7 SLC44A4 SLC7A1 SLC44A1 SLC7A3 SLC44A2 SLC25A29 SLC67A1 SLC38A3 SLC36A4 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 FGF21 SLC6A14 SLC6A12 SLC16A10 SLC6A6 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC35B3 SLC35B2 SLC5A5 ARL2 SLC35D2 SLC28A2 SLC29A1 SLC29A2 SLC4A1 SLC28A3 SLC47A2 SLC22A4 SLC14A1 APOD SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 SLC35C1 SLC17A5 SLC25A5 SLC25A4 SLC25A6 SLC2A13 SLC5A11 SLC5A3 SLC35A1 SLC26A11 SLC35D1 SLC26A2 SLC34A3 SLC34A2 SLC34A1 SLC26A1 SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 SLC5A2 SLCO1B1 SLCO1B3 SLC33A1 SLC6A13 SLC6A5 SLC26A4 SLC26A3 SLC6A11 SLC12A2 SLC22A2 SLC6A2 SLC12A3 SLC22A1 SLC22A12 SLC12A4 SLC2A10 SLC2A1 SLC12A5 SLC6A1 SLC12A1 SLC12A6 SLC6A4 SLC12A7 SLC29A3 SLC24A4 SLC32A1 SLC20A2 SLC35A2 SLC16A1 SLC24A5 SLC17A7 SLC4A7 SLCO1A2 SLC22A8 SLC25A10 SLC22A5 SLC24A1 RUNX1 SLC5A6 SLC6A7 SLC6A9 SLC17A6 PDZD11 AVP SLC15A1 CTNS SLC15A3 SLC15A4 SLC17A8 SLC8A1 SLC8A2 SLC2A3 SLC30A8 SLC30A5 SRI SLC22A3 SLC8A3 SLC4A2 SLC4A3 SLC4A5 SLC5A9 SLC60A2 SLC30A10 SLC5A4 ARL2BP SLC2A14 SLC2A11 SLC2A12 SLC39A10 SLC39A14 SLCO4A1 SLC29A4 SLC17A1 SLCO4C1 SLC28A1 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence TNRC6A TNRC6B UBA52 TP53 MDM2 SP1 MDM4 UBB UBC RPS27A RB1 CDKN2D CDKN2B CDKN2C CDKN2A E2F1 ETS1 E2F2 ETS2 E2F3 MAPK1 CDK6 MAPK3 TFDP1 ID1 TFDP2 ERF CDK4 MOV10 AGO3 AGO4 AGO1 TNRC6C REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus HIRA H2AX H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 PRM2 PRM1 H2BC9 NPM2 H2BC8 SRPK1 H1-8 H2BC5 H2BC11 H2BC3 H3-3B H2BC1 H4C9 METTL23 H2BC12L H2BC26 H2BC21 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation CALM1 PDE1C PDE1B PDE1A NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription DNM2 REST EGR2 TCF12 ATF2 JUNB CDK5 FOS NAB1 ATF1 NAB2 SH3GL3 ARC CDK5R1 TRIB1 TPH1 RRAD EGR3 EGR4 FOSL1 ID2 EP300 ID3 SGK1 LYL1 ID4 EGR1 F3 MEF2D VGF ASCL1 ELK1 CDK5R2 SRF CHD4 ID1 JUND FOSB C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT1 DAG1 POMT2 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways FURIN CALM1 RAB7A GBP1 KPNA1 UBA52 SFPQ B2M PGK1 RNF213 UBB SH3GL3 SH3KBP1 SRC UBC CTNND1 RPS27A STAM CBL CDH1 HGS CTNNB1 EPS15 STX1B CBLL1 SNAP25 MET STAM2 SYT2 SH3GL2 SV2C SH3GL1 SYT1 SV2B MRC1 SV2A VAMP1 VAMP2 STX1A HBEGF UBE2D2 UPK1A EPCAM MAPK1 ATP6V1H MAPK3 CD9 MAP2K1 MAP2K2 NOS2 ENO1 GSK3A DUSP16 EEF2 GBP6 CTSG KPNB1 RAB5A VPS33B HBB CORO1A HSP90AB1 CASP4 TLR2 PDCD6IP GUCY2C HBA2 CALM3 HSP90AA1 CALM2 MAP2K4 LTF GBP2 GBP4 NHERF4 TXNRD1 TRIM27 MAP2K7 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes CBFB RUNX1 CTSV SOCS3 SERPINB13 CTSL CTSK SOCS4 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations FKTN SLC35A4 CRPPA FKRP POMT1 B4GAT1 LARGE2 POMK MGAT5B DAG1 CHST10 RXYLT1 B3GALNT2 LARGE1 SLC35A1 POMGNT2 POMGNT1 POMT2 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome HDAC3 NCOR1 TBL1XR1 TBL1X CALM1 PRKACA HDAC1 SIN3A CAMK4 GPS2 NCOR2 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG PLA2G4B PLA2G3 PLA2G2A PLA2G4F CRLS1 LPCAT4 PLA2G10 PLA2R1 PLA2G1B LPCAT1 PLA2G5 PLA2G4A LPGAT1 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance PPP6C ACD H2AX PPP6R3 LIG1 PRIM2 PRIM1 POLA1 H3-3B POLA2 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP FEN1 ANKRD28 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 DAXX ATRX H2BC1 POLR2A GAR1 POLR2B CDK2 POLR2C H2AB1 POLR2D POLR2E POLR2F POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 POLR2J POLR2K POLR2L DSCC1 RUVBL2 SHQ1 PIF1 H2AC19 CHTF8 H2AC14 RFC5 CTC1 CHTF18 H2BC12L RFC3 TERT STN1 WRAP53 RFC4 TEN1 RFC1 RFC2 H2BC26 H2BC21 DNA2 H2BC17 DKC1 NHP2 BLM H2BC12 RTEL1 H2BC13 PCNA H2BC14 H2BC15 POLD3 POLD4 WRN H2BC11 RUVBL1 POLD1 NOP10 POLD2 H4C9 TINF2 RPA1 RPA2 H2AZ2 RPA3 H2AC20 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus NR4A1 FOXO6 AKT2 FOXO4 RPS6KB2 FOXO1 AKT3 AKT1 FOXO3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones ATF4 ATF6 CALR MBTPS2 MBTPS1 DDIT3 NFYA NFYB NFYC HSPA5 HSP90B1 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control UBE2D1 RCHY1 RPL4 NPLOC4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 UBE2D2 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 VCP RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X ANKZF1 RPL7A KLHDC10 RPLP2 TCF25 NEMF RPL13A ZNF598 RPS3A UBE2D3 PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PELO PSMD12 PSMD11 ELOB ABCE1 RPL26L1 PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ASCC2 ASCC3 LTN1 CUL2 UFD1 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense FURIN ACTG1 PIM1 GBP1 CASP1 SFN PGGT1B GBP3 ACTB GBP2 GBP4 GBP5 FNTA FNTB INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling GATA3 FN1 IL2RG JAK3 MMP9 CCL11 IL6 TYK2 JAK1 CXCL8 S1PR1 FOS COL1A2 CCL22 CDKN1A CCND1 ANXA1 STAT1 STAT3 BCL2 IL4 BCL2L1 IL13 HSPA8 LCN2 CEBPD SOCS5 BCL6 VEGFA HGF ICAM1 TGFB1 ZEB1 FGF2 ALOX5 HMOX1 PTGS2 ITGB1 OPRD1 MUC1 IL18 IL1A IL1B HSP90AA1 BIRC5 RORC VCAM1 IL6R IGHE NANOG TNF IL12B FASLG IL12A FOXO3 IL13RA2 LIF IL13RA1 TNFRSF1B FSCN1 NDN FCER2 MCL1 JUNB TWIST1 RHOU FOXO1 OSM SOCS3 BATF IL4R MMP1 POMC RORA ALOX15 SAA1 NOS2 ITGAM ITGB2 ITGAX TIMP1 F13A1 CD36 TP53 IRF4 OPRM1 MAOA SOX2 MYC IGHG4 IGHG1 AKT1 HSP90B1 IL10 PIM1 IL23R MMP3 LBP PIK3R1 HIF1A SOCS1 JAK2 POU2F1 VIM STAT6 IL17F IL17A MMP2 CCL2 LAMA5 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway ADCY3 GNAL OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 ANO2 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 CNGA2 OR10J3 OR10J5 CNGA4 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 LDB1 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 EBF1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 LHX2 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 GNG13 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 GNB1 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog CUL3 IFT52 GLI1 KIF7 GPR161 INTU TULP3 FUZ ADCY10 GPC5 IFT57 OFD1 DERL2 HHIP OS9 BOC IFT140 SPOP GAS1 CDON NUMB WDR35 VCP SEL1L ADAM17 WDR19 CSNK1A1 GSK3B HHAT DISP2 SCUBE2 ULK3 ERLEC1 PSMD8 DZIP1 SPOPL PSMD6 EVC2 PSMD7 IQCE PSMD2 EFCAB7 PSMD3 EVC PSMD1 DRC4 BTRC SKP1 PSMA5 PSMA6 ITCH PSMA3 PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PRKACB PSMD11 PSMD14 CDC73 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 IHH SHH P4HB SMURF2 ADCY9 SMO PRKAR1B SMURF1 PRKAR2B GLI3 GLI2 PRKACA DHH GRK2 ADCY4 ADCY3 IFT172 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR2A ADCY6 DYNC2H1 ADCY5 PRKAR1A RPGRIP1L IFT88 KIF3A TTC21B PTCH1 ARRB1 SUFU SYVN1 ARRB2 NOTUM IFT122 GNAS MKS1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection GSDMD MEFV CTSG NFKB2 RELA NT5E PYCARD HSP90AB1 NFKB1 HMOX1 C3 CASP1 NLRP3 IL18 PSTPIP1 IL1A IL1B P2RX7 P2RX4 TXNIP TXN C3AR1 SUGT1 ENTPD1 ENTPD5 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC PLA2G4B PLA2G4F PLA2G4E PLA2G4C GPCPD1 PLA2G15 PLBD1 PLA2G4A PLA2G4D PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL8 SSTR3 C5AR2 C5AR1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 C3 C5 CCR5 APP MC4R EDNRB EDN1 EDN3 MC3R POMC MC1R MC5R C3AR1 CX3CR1 CXCR4 CXCL12 MRGPRD PF4 PDYN AGTR2 FPR1 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 PNOC GPR37 CCL13 CCL11 CCL19 CCL17 CCL16 CCL25 CCL22 CCL21 CCL20 CCL28 CCL27 CXCL13 CXCL16 PSAP CXCL10 CXCL11 ECE1 ECE2 ANXA1 PRLHR CCL7 CCL5 CCL4 CCL3 CCL1 APLN GPR37L1 KEL NLN MC2R PENK PPY CCR10 CCR1 PPBP CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 GAL OPRD1 NPB CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR CCL3L3 PYY CXCL6 CXCL9 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 GRPR EDNRA PROK2 PROK1 UTS2R GPER1 NPFF TRHR UTS2B AGTR1 NPY5R SSTR1 FPR2 SSTR2 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R OPRL1 NMB XCR1 NMBR NMS NMU OXTR QRFP MLN AVPR1B NPY ACKR4 BRS3 AVPR2 ACKR3 OXT ACKR2 AVP ACKR1 CCKAR AVPR1A EDN2 TACR2 TACR3 TACR1 F2 SAA1 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R AGT MT-RNR2 F2RL1 F2RL2 F2RL3 PMCH GHSR OPRM1 F2R UTS2 NTS KNG1 MCHR2 TAC3 TAC1 NMUR2 NMUR1 MLNR TRH OPRK1 MCHR1 BDKRB2 BDKRB1 QRFPR XCL2 XCL1 CCK HCRTR2 HCRTR1 KISS1 SST CCL2 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions ITGA1 ITGB1 CHL1 NRP1 CNTN6 ANK1 HSPA8 ITGA10 ITGA2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases CEP57 CETN2 PLK1 CEP164 ACTR1A CCNB1 PCM1 CNTRL CDK1 CEP290 NINL CCNA2 CCNA1 RAB8A OFD1 CDKN1A TUBB HAUS4 HAUS3 FZR1 HAUS6 HAUS5 E2F1 TUBG1 E2F3 FBXL18 HMMR HAUS2 HAUS1 CDK2 CEP63 NEK2 SFI1 SDCCAG8 PPP2R1B PPP2R1A DCTN2 SSNA1 SGO1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E PHLDA1 CCNB2 NEDD1 ALMS1 CEP41 CEP43 XPO1 YWHAG EP300 DYNLL1 HSP90AA1 CKAP5 PSMD8 RBBP4 PSMD6 MAPRE1 PSMD7 PSMD2 PAFAH1B1 PSMD3 MYBL2 DYNC1I2 PSMD1 BTRC SKP1 PPP2CA PPP2CB FBXW11 AURKA PSMA5 PSMA6 PSMA3 CLASP1 YWHAE PSMA4 PSMA1 PSMA2 UBA52 PPP1R12A DYNC1H1 GTSE1 CDC25C PSMD12 FKBPL PSMD11 NDE1 CDC25A PSMD14 CDC25B PSMD13 CENPF CUL1 PSMA7 HJURP MIS18BP1 PSMB6 PSMB7 PSMB4 PSMB5 UBB TPX2 PSMB2 OPTN PSMB3 TUBGCP2 UBC PSMB1 RPS27A TUBGCP5 ADRM1 TUBGCP6 SEM1 TUBGCP3 CPAP TUBGCP4 RBX1 PSMC5 TUBG2 PSMC6 FBXL7 MZT2B PSMC3 MZT2A PSMC4 NME7 PSMC1 PPP1CB LIN54 MZT1 PSMC2 LIN52 PKMYT1 LIN37 LIN9 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B CCNH TICRR FOXM1 AKAP9 PRKAR2B PPP2R2A TUBA4A PRKACA TP53 CDK7 CCP110 MNAT1 CEP250 CDK5RAP2 CEP135 CEP131 CSNK1D TUBA1A HSP90AB1 CEP70 CEP72 CEP192 CEP76 CEP78 PPP2R3B PLK4 AJUBA ODF2 TUBB4B TUBB4A CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects KCNMB1 KCNMA1 PDE1B PDE2A PDE1A PRKG2 PDE5A KCNMB2 ITPR1 KCNMB3 KCNMB4 IRAG1 PDE9A PDE11A PDE10A DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations POMT1 DAG1 POMGNT1 POMT2 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases TNKS2 RNF146 GATA3 TGFBR1 SUDS3 USP17L4 USP17L5 USP17L8 RNF128 USP34 MDM2 MDM4 USP7 TADA2B USP2 WDR20 CCNA2 USP17L3 CCNA1 USP17L1 HGS VDAC3 STAM2 VDAC2 USP5 USP3 VDAC1 H2BC9 H2BC8 H2BC5 FKBP8 SKP2 H2BC3 H2BC1 USP10 DDB2 H2AC8 CDC20 H2AC6 H2AC7 USP17L30 MAT2B USP17L21 USP17L20 USP17L22 H2BC26 USP17L2 H2BC21 TOMM70 USP17L15 USP9X USP17L18 TOMM20 RCE1 USP17L17 USP17L19 USP17L10 TADA3 TAB1 H2BC17 USP17L12 USP17L11 H2BC12 USP17L13 H2BC13 H2BC14 H2BC15 TRAF2 H2BC11 RUVBL1 USP37 USP47 USP48 PSMD8 CFTR USP49 USP42 PSMD6 USP44 BIRC2 PSMD7 TRAF6 BIRC3 PSMD2 PSMD3 USP16 PSMD1 USP12 RIPK1 IKBKG USP19 KEAP1 MAP3K7 USP24 USP25 AXIN2 USP26 H2BC18 PSMA5 USP20 PSMA6 USP22 PSMA3 USP28 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 BECN1 PSMD13 RNF123 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC SIAH2 PSMB1 RPS27A IDE ADRM1 SEM1 NFKBIA TAF10 PSMC5 PSMC6 USP30 PSMC3 PSMC4 PSMC1 FOXO4 USP14 IL33 PSMC2 USP18 RHOT1 WDR48 POLB ADRB2 USP21 USP4 SMAD2 SMAD1 SMAD4 CYLD SMAD3 AR SMURF2 CLSPN IFIH1 SMAD7 PTRH2 TP53 RIGI H2AC17 H2AC12 AXIN1 CCP110 KAT2A H2AC1 USP15 H2AC19 H2AC25 H2AC14 H2AC21 ATXN7 PTEN MYC USP8 SNX3 ARRB1 ARRB2 USP11 MUL1 HIF1A USP33 UFD1 TRRAP H2AC20 OTUB1 USP13 TNKS ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCD2 ABCD3 ABCA3 ABCA10 PEX3 ABCG4 APOA1 ABCA6 ABCA2 ABCA5 ABCA9 ABCA7 PEX19 ABCD1 ABCG8 ABCA12 ABCG1 ABCG5 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes CCNK CCNT2 ELL CCNT1 GTF2B TBP NCBP1 NCBP2 GTF2A1 GTF2A2 TAF9 SUPT4H1 GTF2E1 GTF2E2 PCF11 TAF13 TAF11 CDK9 TAF8 TAF6 TAF5 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 PHAX CDK7 INTS1 INTS3 INTS2 SP1 SNAPC5 INTS5 SNAPC1 INTS4 SNAPC2 SRRT INTS7 SNAPC3 INTS6 SNAPC4 INTS9 ZNF143 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 NABP1 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 POU2F1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR RELA TRAF6 PSENEN ADAM17 PSEN2 PSEN1 APH1A NGFR NCSTN APH1B NFKB1 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response CASP3 CASP7 CYCS XIAP CASP9 DIABLO APAF1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LPL FURIN PCSK6 LMF2 PCSK5 LMF1 MBTPS1 LIPC CREB3L3 GPIHBP1 FGF21 APOA4 APOC2 APOA5 MBTPS2 ANGPTL8 ANGPTL3 ANGPTL4 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling CALM1 FOXO3 MMP9 FOS SRC S1PR3 PRMT1 NOS3 TGFA ELK1 CDKN1B EREG UHMK1 BTC EPGN CCND1 HBEGF GNGT1 NRAS MAPK1 GNGT2 HRAS MAPK3 EGF ESR1 CAV1 BCL2 AREG GNAT3 ESR2 PTK2 GNAI3 EGFR IGF1R ZDHHC7 GNG10 GNG3 ZDHHC21 GNAI1 GNG2 GNAI2 CAV2 AKT2 MMP7 GNG5 PRKCZ GNG4 AKT3 GNG7 GNG8 AKT1 XPO1 STRN SPHK1 PDPK1 MMP3 PIK3R3 SRF PIK3R2 PIK3CA PIK3R1 HSP90AA1 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 MMP2 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 TBK1 IRF3 UBA52 IRF7 TICAM1 TANK TRAF3 UBB IKBKE TLR3 OPTN UBC RPS27A MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing DDX46 DDX42 RBM17 SMNDC1 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 PHF5A SNRPN CHERP PTBP1 SNRPA1 DNAJC8 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 TCERG1 SRRM2 SNRPG SNRPC SRSF8 SNRPA SNRPE HTATSF1 CPSF4 RBM25 PPP1R10 SNRPF SNRNP70 PRPF40A SNRPB TUT1 PPP1R8 SRSF10 SRSF12 RBM39 HNRNPH1 HNRNPH2 RBM5 PABPN1 PAPOLG UBA52 NCBP1 NCBP2 UBB UBC RPS27A FIP1L1 PPP1CB HNRNPU EIF4A3 PPP1CA CASC3 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 POLR2A THOC6 POLR2B SRRM1 POLR2C DDX39A POLR2D DDX39B POLR2E SARNP POLR2F ZC3H11A POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 XRN2 FYTTD1 LUZP4 GTF2F1 RBM8A GTF2F2 POLDIP3 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP ALYREF SRRT UPF3B MAGOHB RNPS1 FUS HNRNPA1 HNRNPA3 TRA2B RBBP6 CCAR1 PCBP1 CPSF7 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC RBMX DHX9 HNRNPA2B1 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS NTRK3 HRAS NTF3 SOS1 NRAS INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production KPNB1 NOS2 KPNA1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines CXCL9 CXCL1 CXCL3 CCR5 CXCL2 CXCL5 CCL13 CCL11 CXCL8 CCL19 CCL17 CCL16 CCL25 CCL22 CCL21 CCL20 XCR1 CCL28 CCL27 CXCL13 CXCL16 ACKR4 ACKR3 ACKR2 CXCL10 CXCL11 CCL7 CCL5 CCL4 CCL3 CCL1 CCR10 CX3CR1 CCR1 PPBP CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 CXCR4 CCR2 CXCL12 XCL2 XCL1 CXCR5 CXCR6 CXCR1 CXCR3 CXCR2 CCRL2 CCL3L3 PF4 CCL2 CXCL6 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis POMC HSD3B2 CGA HSD3B1 LHB SRD5A2 SRD5A1 CYP17A1 SRD5A3 HSD17B3 HSD17B12 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT1 DAG1 POMT2 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 VWF GP1BA ADAMTS13 GP9 GP1BB VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate AOX1 PDXK PNPO AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA DBT BCKDHB DLD REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase PPP6C ACD DKC1 PPP6R3 NHP2 RTEL1 RUVBL1 NOP10 RUVBL2 SHQ1 PIF1 TINF2 TERT WRAP53 TERF1 GAR1 TERF2 CDK2 CCNA2 CCNA1 POT1 TERF2IP ANKRD28 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) ATM H2AX HERC2 H2BC9 H3-4 PIAS4 H2BC8 H2BC5 H2BC3 H2BC1 BRCC3 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 NBN DCLRE1C RIF1 LIG4 H2BC12L PAXIP1 NHEJ1 XRCC4 TDP2 TDP1 H2BC26 UBE2V2 H2BC21 POLL UBE2N MDC1 H2BC17 H2BC12 POLM H2BC13 H2BC14 H2BC15 H2BC11 BARD1 H4C9 PRKDC RAD50 XRCC6 XRCC5 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy DUSP16 RAB7A GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation GATA4 TRIM33 TEAD2 TEAD4 YAP1 CDH1 CTNNB1 SNW1 NOG LFNG DLL1 TCF7 FOXC2 FGFR1 FOXC1 MAMLD1 OSR1 FGF2 FGF4 PAX2 BMP4 EP300 PAX8 LHX1 TFAP2A TFAP2B TFAP2C ZIC2 CREBBP LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TCF7L2 PSMD1 HES7 TCF7L1 TBPL2 MESP2 MSGN1 RIPPLY2 PAX7 DLL3 PSMA5 NOTO PSMA6 MSX1 NANOG PAX6 PSMA3 PSMA4 POU5F1 PSMA1 PSMA2 MAML2 MAML1 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 MYB PSMA7 FOXH1 ZIC1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 PAX3 SEM1 NOTCH1 PSMC5 DLX5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 IHH SHH SMAD2 SMAD4 SMAD3 KAT2B KAT2A SOX2 ZEB2 FGF8 SOX1 EOMES GATA6 CXCR4 GBX2 OTX2 TBXT SOX17 TBX6 POU3F1 GSC ZNF521 MIXL1 RBPJ WNT3A FOXA1 FOXF1 SNAI1 EPHA4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 CRCP POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements H2AX ZNF610 ZNF324 SMARCB1 DNMT3L SPOCD1 C19orf84 TRIM28 ZNF320 ZNF264 H3-3B SMARCC1 SMARCC2 H3C8 ZNF317 ZNF30 ZNF257 H2AJ H3C15 ZNF708 H2BC9 H2BC8 H2BC5 ZNF547 H2BC3 SMARCA2 SMARCA4 H2BC1 MPHOSPH8 ACTL6A H2AB1 H2AC8 H2AC6 H2AC7 ZNF765 ZNF93 ZNF816 ZNF534 ZNF778 SMARCD3 ZNF224 MBD3 H2BC26 H2BC21 MTREX PIWIL4 GATAD2B GATAD2A H2BC17 ZNF519 H2BC12 H2BC13 H2BC14 H2BC15 SMARCD1 HDAC2 SMARCD2 H2BC11 ZNF454 CHD4 RBBP4 CHD3 ZCCHC8 RBBP7 SMARCE1 H2AZ2 RBM7 MTA2 TASOR PPHLN1 ZNF680 DNMT3A MORC2 ZNF354A MTA1 HDAC1 ZNF141 MTA3 ZNF382 UBE2I ACTB ZNF669 ZNF136 ZNF425 CBX5 SUMO2 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SS18L1 ZNF418 ARID1A ARID1B H2AC19 H2AC14 H2BC12L ZNF649 ATF7IP SETDB1 EHMT2 EHMT1 H4C9 ZNF33A ZNF331 H2AC20 ZNF28 ZNF273 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins ETV6 STAT5A STAT5B PIM1 GAB2 NOX4 ZMYM2 SOS1 CDKN1A PIK3R1 PIK3CA NRAS GOLGB1 HRAS SPTBN1 MYO18A TRIP11 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction DMD KCNK6 KCNK7 KCNK1 PAK1 PAK2 PXN NPPA NPR1 NPR2 NPPC CORIN TNNI1 TNNI2 MYBPC3 TMOD1 MYBPC1 MYBPC2 ACTN3 CALM1 TMOD4 TNNC1 TMOD2 TNNC2 NEB MYL4 MYH3 DES MYL1 TNNT1 MYL2 TNNT2 MYL3 TNNT3 MYH8 TCAP MYH6 NKX2-5 ANXA2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 KAT2B ACTN2 TTN KCNH2 KCNK10 KCNK13 TMOD3 KCNK16 KCNK17 KCNK18 KCNQ1 HIPK1 PDE5A HIPK2 VIM KCNK9 MYL9 KCND1 KCND2 SCN11A KCND3 GATA4 SCN9A SCN1B SCN1A SCN10A KCNA5 SCN8A KCNJ14 SCN3B SCN3A KCNK2 KCNK3 KCNK4 TRIM72 GUCY1B2 GUCY1B1 ITGB5 DYSF LMOD1 MYL6B SCN2A CACNA1H MYL12A SCN2B MYLK MYL12B CACNA1G CACNA1I SCN5A CALD1 ANXA6 MYL10 MYH11 GUCY1A2 GUCY1A1 ANXA1 CAV3 TPM4 SCN4A TPM3 SCN4B MYL11 TPM2 SCN7A TPM1 SORBS1 SORBS3 MYL5 MYL6 MYL7 CACNA2D2 CACNA1C CACNG6 FGF14 RANGRF FGF13 FGF12 FGF11 CACNB1 CACNB2 CACNG8 KCNJ2 CACNG4 KCNJ4 ITGA1 KCNJ12 KCNIP3 ALDH2 KCNK5 KCNK12 KCNK15 RYR1 RYR2 AHCYL1 ATP2A3 ATP2A2 ATP2A1 AKAP9 SLC8A1 RYR3 SLC8A2 SLN NOS1 CLIC2 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 TRDN ASPH STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A MME ATP1A4 ITPR1 ATP1A3 CES1 ITPR2 ATP1A2 ITPR3 ATP1A1 SRI PLN TNNI3 CACNG7 CAMK2G KCNJ11 DMPK ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 FXYD4 FXYD3 FXYD2 FXYD1 KCNIP1 FKBP1B KCNIP2 FXYD7 KCNIP4 FXYD6 WWTR1 TRPC1 TLN1 VCL TBX5 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 BCKDHA DBT BCKDHB DLD COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6A TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle ARHGAP12 RAB7A VAMP3 FARP1 DIAPH2 ARHGAP39 ARHGAP21 LMNB1 SRGAP2 MTMR1 POTEE MCAM SOWAHC FAM169A ADD3 VANGL1 ARHGAP32 DIAPH3 ESYT1 MYO9B SNAP23 BAIAP2L2 SYDE1 PIK3R2 PIK3R1 BAIAP2L1 STEAP3 AKAP12 ARHGAP1 ACTN1 SLC4A7 SENP1 ARHGAP5 RHOF ACTB CAPZB TMPO DIAPH1 CAV1 BASP1 DEPDC1B TOR1AIP1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis CAST YWHAE APP JUN CDKN2A FASLG SOD2 TP53 CDC25C C1QBP FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists DKK1 DKK2 DKK4 SFRP1 SFRP2 WNT3A SOST KREMEN1 KREMEN2 LRP5 LRP6 WNT5A WIF1 WNT9A WNT4 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import TIMM23 TIMM22 TIMM21 NDUFB8 TOMM40 SLC25A12 TAFAZZIN TIMM9 TIMM13 SLC25A13 TIMM10 TIMM8B TIMM8A IDH3G SLC25A4 GFER SLC25A6 ATP5MC1 TOMM7 TOMM5 TOMM6 ATP5F1A CHCHD3 SAMM50 ATP5F1B HSPA9 MTX1 PMPCB MTX2 PMPCA VDAC1 COQ2 GRPEL1 OTC HSPD1 TOMM70 TOMM20 TOMM22 CHCHD4 CHCHD5 CHCHD2 CHCHD7 CMC4 CMC2 PAM16 COX19 COX17 TIMM50 PITRM1 LDHD GRPEL2 HSCB DNAJC19 BCS1L COA4 CHCHD10 TIMM44 CS TIMM10B ACO2 TIMM17A TIMM17B CYC1 FXN COA6 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport SERPINA1 HSPH1 PPP6C TFG PPP6R1 PRKAG1 PPP6R3 PRKAG2 TMED2 CTSC CD3G TRAPPC2L LMAN1L F5 F8 CD3D PRKAG3 SBF2 TRAPPC6A TBC1D20 RAC1 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TFRC TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 FTH1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 FTL SEC23IP CNIH1 KIF20A KLC1 CNIH2 KLC4 CNIH3 KLC3 FOLR1 KLC2 BET1 NEDD8 KIF11 KIF15 KIF23 EGF KIF22 AREG KIF26A TF COPS5 SCARB2 ITSN2 AGFG1 GAPVD1 BIN1 AMPH GRK3 CLTCL1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A YWHAG SYNJ2 TOR1B SNAP23 SYT9 SYT8 SNAP91 DAB2 AAK1 IL7R COL3A1 PICALM STON1 STON2 COL4A2 PIK3C2A COL4A1 SLC2A8 SGIP1 COL7A1 EPS15L1 PRKAA2 ARFGAP1 OCRL EPN1 EPN2 GAK CTTN ARF6 LRP2 FCHO1 FCHO2 RACGAP1 REPS2 UBQLN1 UBQLN2 HIP1R SNX18 NECAP2 NECAP1 CD4 SYT11 TRIP10 AP2A1 AP2A2 LDLRAP1 AP2M1 MAP1LC3B SPARC STXBP3 AP2S1 RAB27B LDLR CHRM2 GJA1 AP2B1 GJB2 ALB ADRB2 MAN2A1 MYO5A ARPC1A WASL HYOU1 GNS CD163 MYH9 ARFGAP2 DVL2 KDELR1 STAB2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 MYO1C CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SFN SNX5 TBC1D8B SNAPIN SORT1 DTNBP1 PUM1 TPD52L1 GOLGB1 YIPF6 ACBD3 COL1A1 SYNJ1 ALS2 COL1A2 GJC1 GJD2 MAN1A2 MAN1C1 GJA10 MAN1A1 CLINT1 DENND1C DENND1B GDI1 DENND5B DENND1A KDELR3 GDI2 RINL TRAPPC12 DCTN1 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 NSF DENND6A RIN1 RIN2 DENND3 RAB21 ALS2CL CHML GRIA1 ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB39B TRAPPC8 RAB12 EGFR RAB18 VPS45 RAB3GAP2 RAB3GAP1 MON1A MON1B COLEC12 MSR1 SCARA5 MARCO SCGB3A2 CALR FNBP1L FNBP1 CLTC CLTA HSP90AA1 UBA52 DCTN6 DCTN5 DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 UBB OPTN UBC RPS27A SAA1 AP3B1 GALNT1 CD36 RAB27A KIFAP3 CSNK1D HIP1 KIF3B KIF3A TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 KIF3C VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 RAB3IP CHMP5 ARF4 AP1G1 ACTR1A AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 GALNT2 SH3GL3 SH3KBP1 STAM CBL RAB8A HGS EPS15 EXOC8 TGFA STAM2 SH3GL2 EXOC7 SH3GL1 RALA YWHAB IGHV3-23 APOE IGLV IGLV2-8 IGKV1-16 AGPAT3 IGKV1-17 IGKV1-12 SBF1 IGHV3-7 SCARF1 IGHV3-9 V2-11 IGHV3-30 EXOC4 V3-4 EXOC3 V3-3 EXOC6 V2-17 V3-2 IGHV3-33 EXOC5 V2-15 IGKV1D-39 EXOC2 V2-19 IGKV1D-33 EXOC1 IGKV2D-28 IGKV4-1 IGHV7-81 DCTN2 DCTN3 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 GBF1 IGLV6-57 IGLV2-14 RAB11A IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 HBB TRIP11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 APOB IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 C2CD5 IGHV ITSN1 SLC2A4 IGKV2-29 RALGAPA2 IGKV2-28 IGLC3 TBC1D1 RALGAPB APOA1 IGLC1 HBA2 IGLC2 TBC1D4 V1-9 ASPSCR1 V5-4 RAB10 V1-7 RAB14 GJB1 V5-1 RAB13 USP6NL V1-5 SCOC V1-3 CFTR IGKV3D-20 SYS1 V5-6 GCC2 GCC1 RABEPK YWHAQ IGLV3-19 RAB43 GOLGA4 IGKV2-30 IGHV2-70 GOLGA1 ARFGAP3 IGHV2-5 ARFIP2 NAA30 IGLV3-1 IGHV3-48 COG8 IGLV3-25 COG7 IGLV3-27 COG6 COG5 IGKC IGLV3-21 COG4 INS LRP1 COG3 CALM1 IGKV1-39 GJA3 COG2 RAB7A IGKV1-33 GJA5 V4-6 COG1 YWHAE GJA4 VAMP3 IGHV3-53 APP NAA35 GJA9 V4-2 NAA38 GJA8 VAMP4 IGLC7 GJC2 V4-1 NAPA GJB4 NAPB IGKV5-2 GJB3 TMF1 IGKV1-5 GJB6 STX16 IGLC6 GJB5 RHOBTB3 GJB7 LMAN1 ARL1 GJD4 STX5 GOLGA2 NAPG GJD3 YKT6 STX10 TGOLN2 ARFRP1 VPS51 VPS53 PRDX1 VPS52 VTI1A YWHAH STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B RABGAP1 YWHAZ GABARAP GGA2 RABGEF1 GGA1 GGA3 TBC1D13 TBC1D10C S100A9 TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B WNT5A TBC1D2 PLIN3 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B PLA2G6 CHM ARF5 ARCN1 RAB5B RAB5C RAB5A CD55 GPS1 KDELR2 MYO6 FZD4 MIA2 CD5L COPS4 SSC5D COPS2 GOSR1 ANK2 ANK3 ANK1 TSC2 TSC1 SPTBN4 SPTBN5 SPTA1 COPZ2 SPTBN1 COPZ1 SPTBN2 KIF4B KIF4A RAB41 SYT2 SYT1 EREG SPTAN1 SPTB BTC VAMP2 RAB30 EPGN DNM1 HBEGF RAB36 DNM3 ARF1 CTSZ AP4E1 CLTB BET1L AP4M1 AP1G2 BLOC1S1 SEC23A CLVS2 AP4S1 CLVS1 SAR1B TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 SEC24B DYNC1LI1 SEC24A DYNC1LI2 ZW10 SEC24D TMED3 SEC24C TMED7 SLC18A3 TMED9 RAB3A KIF18A HMGB1 SEC13 COPG2 COPG1 COPB2 COPA DYNLL1 COPB1 MAN2A2 TMEM115 DYNLL2 CHMP4C COPE KIF2A CHMP4B CHMP3 CHMP4A KIF2C CUX1 CHMP6 KIF2B CHMP7 PAFAH1B1 DYNC1I2 COPS7B COPS7A COPS3 COPS6 CHMP2B DYNC1I1 CHMP2A COPS8 DYNC1H1 CENPE AGTR1 LNPEP AVPR2 AVP TJP1 STX4 GOLIM4 TACR1 CAPZB CYTH3 CYTH2 GOLGA5 CYTH4 SNAP29 CYTH1 ALPP CAPZA1 CAPZA2 STAB1 GRK2 HP KIF5C PLA2G4A HPR HPX KIF5B IGHA1 KIF5A IGHA2 AMBP JCHAIN KIF28P KIF12 USE1 AKT2 KIF19 KIF13B AKT3 KIF1C KIF21A AKT1 KIF1B KIF21B PRKAB2 HSP90B1 KIF1A MIA3 KIF25 KIF6 PRKAB1 KIF27 RINT1 MASP1 KIF9 KIFC2 KIF16B KIFC1 KIF20B NBAS COLEC11 ARRB1 STX18 BNIP1 ARRB2 SURF4 KIF18B KIF26B APOL1 ARF3 MCFD2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex MCM6 CDC6 MCM2 PRIM2 PRIM1 POLA1 POLE POLA2 ORC5 ORC4 ORC6 ORC1 MCM8 GMNN ORC3 ORC2 CDT1 MCM10 DBF4 RPA4 CDC7 RPA1 RPA2 CDC45 POLE4 CDK2 MCM7 RPA3 POLE2 MCM3 POLE3 MCM4 MCM5 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine CTH CBS DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 GCK NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 GCKR AAAS SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LRP5 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade VTN CD59 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 CD81 V3-3 C4BPA V2-17 C4BPB V3-2 CLU IGHV3-33 V2-15 SERPING1 IGKV1D-39 CPB2 V2-19 CFH IGKV1D-33 C5AR2 C5AR1 IGKV2D-28 CFI IGKV4-1 C6 IGHV7-81 C7 C9 CD19 V1-11 C8B IGKV2D-30 C8A V1-16 C8G V1-13 CR2 IGHV4-59 CD46 IGHV1-69 CPN2 CPN1 CFHR2 IGLV2-11 CFHR1 IGLV1-40 CFHR4 IGLV1-47 CFHR3 IGLV6-57 CFHR5 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CR1 C3 C4A IGKV3-20 C5 IGHV4-34 C4B_2 IGHV1-2 CFB IGHV1-46 C2 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 ELANE IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 PROS1 F2 C3AR1 IGHG3 IGHG4 IGHG1 IGHG2 CD55 FCN1 FCN2 FCN3 MASP1 CFD MBL2 CRP C1QB C1QA COLEC11 COLEC10 C1S C1R GZMM C1QC DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation MCM6 MCM2 LIG1 PRIM2 PRIM1 POLA1 POLA2 RFC5 RFC3 RFC4 MCM8 RFC1 RFC2 FEN1 DNA2 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 GINS1 RPA2 GINS2 CDC45 MCM7 GINS3 GINS4 RPA3 MCM3 MCM4 MCM5 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway IFIH1 RNF135 EP300 TBK1 TRIM25 IRF3 SIKE1 MAVS IFNB1 TRIM4 CREBBP RIGI IRF7 TRAF3 IKBKE DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases PPP2CA PPP2CB PPP2R1B PPP2R1A MAPKAPK2 JUN ATF2 RPS6KA1 FOS ATF1 MEF2A DUSP4 DUSP3 RPS6KA5 MAPK9 VRK3 MAPK8 DUSP6 MAPK7 DUSP7 ELK1 PPP2R5D MAPK10 MEF2C RPS6KA3 RPS6KA2 MAPK1 MAPK3 MAPK14 MAPK11 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body CD320 LMBRD1 ABCC1 LRP2 TCN2 LDLRAP1 ABCD4 TCN1 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses IDUA IDS HGSNAT SGSH GUSB GALNS ARSB GNS GLB1 NAGLU HYAL1 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol CYP8B1 NCOA1 BAAT NCOA2 AKR1C3 ACOX2 HSD3B7 SLC27A5 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 ABCB11 CYP7A1 CYP27A1 ACOT8 HSD17B4 AMACR RXRA SLC27A2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction STRA6 RDH12 OPN1LW LRAT RLBP1 OPN1MW TTR NAPEPLD ABCA4 RBP4 RDH5 OPN1SW RBP1 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer SOS1 EREG PIK3R1 BTC PIK3CA SHC1 NRG2 HBEGF NRG3 EGFR NRG4 NRAS HSP90AA1 GAB1 CDC37 HRAS ERBIN PLCG1 EGF PTPN12 ERBB2 NRG1 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism RIDA SDS SDSL TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex CDC6 MAX TOP2A LIN54 PCNA LIN52 LIN37 HDAC1 LIN9 CDC25A E2F1 E2F4 E2F5 RBL2 RBL1 TFDP1 RBBP4 TFDP2 MYC ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway GNAI3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNAT3 ADCY9 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 UBE2D1 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 RCHY1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 APEH MRPS6 MRPS5 MRPL43 MRPL44 TUFM MRPS18C MRPL52 OXA1L MRPL53 UBE2D2 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 EEF1B2 MRPS30 EEF1G MRPL15 EEF1A1 MRPL12 EEF1D MRPL57 EEF1A2 MRPL13 EIF5 EEF1A1P5 MRPL54 EEF2 EIF5B MRPL10 MRPL11 MRPL55 VCP MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 PPA1 DDOST ANKZF1 KLHDC10 TCF25 NEMF ZNF598 MT-CYB EIF2B5 EIF2B4 EIF2B3 EIF2S3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 ELOB ELOC QARS1 TARS1 AARS1 HARS1 FARSA RARS1 FARSB MALSU1 MIEF1 MARS1 MTFMT YARS1 NARS1 CARS1 RBX1 VARS1 MTIF2 DARS1 MTIF3 WARS1 LARS1 MTRFR SARS1 MTRES1 EEF1E1 KARS1 IARS1 AIMP1 AIMP2 EPRS1 GSPT2 GSPT1 PABPC1 CUL2 MT-CO1 NDUFAB1 ETF1 UFD1 MT-CO2 MT-CO3 EIF4EBP1 EIF4E EIF4B EIF4G1 RPL4 NPLOC4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 SSR1 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 SRPRA SRPRB RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 HEMK2 RPS7 RPS8 RPL23 SEC11A RPS5 SEC11C RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 TRMT112 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RARS2 AARS2 MARS2 PARS2 RPS21 SPCS3 RPS24 SPCS2 DARS2 HARS2 RPS23 SPCS1 RPLP1 YARS2 FARS2 RPLP0 WARS2 GARS1 LARS2 RPS4X RPL7A SARS2 PPA2 RPLP2 NARS2 TARS2 RPL13A IARS2 VARS2 RPS3A UBE2D3 CARS2 PSMD8 EARS2 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A MT-ND6 PSMA2 RPL23A MT-ND4L UBA52 RPL22L1 MT-ND4 FAU MT-ND5 PELO PSMD12 MT-ND2 PSMD11 ABCE1 RPL26L1 MT-ND3 PSMD14 MT-ND1 PSMD13 MTRF1 GFM2 MRRF PSMA7 MTRF1L PSMB6 PSMB7 MT-ATP6 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M SEC61A2 EIF3K MT-ATP8 EIF3L SEC61A1 EIF3I SEC61G EIF3J SEC61B EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B ASCC2 ASCC3 LTN1 SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RPN2 RPN1 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress RAD1 MCM6 CDC6 MCM2 RAD9B ATR RAD9A CDC25C CDC25A CHEK1 ORC5 RFC5 ORC4 RFC3 ORC6 ORC1 RFC4 MCM8 ORC3 ORC2 RFC2 HUS1 MCM10 DBF4 CDC7 ATRIP RPA1 RPA2 CDC45 CDK2 MCM7 RPA3 MCM3 CLSPN MCM4 RAD17 MCM5 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex PPP1CC CSNK2B CRY2 CRY1 PER2 PER1 PPP1CB PER3 PPP1CA CSNK1E CDK5 CSNK1D CSNK2A1 CSNK2A2 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF RASA1 RAC1 FLT4 VAV1 CTNND1 SHB CTNNB1 SH2D2A PAK1 NOS3 NRP2 RICTOR PAK3 SHC2 PAK2 NRAS HRAS PLCG1 CDH5 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 CRK THEM4 FLT1 VEGFA HSPB1 PXN PRR5 PRKCZ RHOA PIK3CB MLST8 NCKAP1 NCF1 NCF2 NCF4 PDPK1 BRK1 CYFIP1 PIK3CA CYBB HSP90AA1 JUP CYBA CDC42 FYN NCKAP1L WASF1 MTOR WASF2 PRKCB ELMO2 DOCK1 BAIAP2 CALM1 ABI2 PGF ABI1 PRKACG PRKACB KDR ELMO1 AXL PTK2B CYFIP2 CAV1 AHCYL1 VEGFB VEGFC VEGFD PRKACA VAV3 ITGAV PTK2 PRKCD PRKCA VAV2 ITPR1 ITPR2 AKT2 NRP1 ITPR3 AKT3 AKT1 ROCK1 ROCK2 AAMP SPHK1 BCAR1 TRIB3 ITGB3 MAPKAP1 PIK3R2 PIK3R1 NCK2 CTNNA1 NCK1 WASF3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation SNAP25 ABAT SYT1 SLC6A13 VAMP2 SLC6A12 CPLX1 STX1A SLC6A11 DNAJC5 GAD1 GAD2 SLC6A1 SLC32A1 ALDH5A1 RAB3A RIMS1 HSPA8 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants FLT3 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex HDAC3 NCOR1 TBL1XR1 TBL1X GPS2 NCOR2 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters AHCYL2 SLC4A1 SLC4A2 SLC4A7 SLC4A10 SLC4A3 SLC4A8 SLC4A5 SLC4A9 SLC4A4 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta UBE2L6 CHUK HERC5 ITCH UBE2K APP UBA52 UBE2D1 RELA TANK TRAF3 UBB IKBKE NKIRAS1 NKIRAS2 UBC RPS27A NFKB1 NFKBIA ATG12 DHX58 NLRX1 ATG5 RNF125 TRIM4 RNF216 IFNB1 NFKBIB NLRC5 UBE2D2 CASP10 AGER S100A12 TNFAIP3 MAP3K1 S100B SAA1 TKFC IFNA5 CYLD IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TBK1 TRIM25 IRF3 IFNA21 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI NFKB2 PIN1 TAX1BP1 HSP90AB1 ISG15 TOMM70 HMGB1 UBA7 CASP8 EP300 PCBP2 CREBBP TRAF2 OTUD5 HSP90AA1 IRF7 UBE2D3 IKBKB TRAF6 IKBKG RIPK1 FADD FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation RAC1 FOS VAV1 MAPK9 MAPK8 PAK1 PAK2 MAPK10 IGHV3-23 IGLV NRAS IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 HRAS IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 GRAP2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 JUN V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 MAP3K1 PLCG2 VAV3 SYK VAV2 LYN MAP2K4 LCP2 MAP2K7 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins POM121C SUMO2 NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 PIAS4 UBE2I TOPORS NUP205 POM121 NUP107 NUP188 SUMO1 AAAS ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress DIS3 PARN EXOSC7 EXOSC6 NFYA EXOSC5 NFYB EXOSC4 NFYC EXOSC9 KHSRP IGFBP1 EXOSC8 EXOSC3 EXOSC2 CXCL8 EXOSC1 HERPUD1 CEBPB DCP2 ATF4 ATF6 ATF3 CEBPG ASNS DDIT3 CCL2 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 KPNB1 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) H2AX H3-3B TEAD4 KDM6B H3C8 H2AJ EIF4E EIF4B YAP1 HIRA EIF4G1 H3C15 EIF4A2 EIF4A1 H2BC9 H2BC8 H2BC5 EIF4A3 H2BC3 KDM5A UHRF1 KDM6A H2BC1 STPG4 AICDA CNOT6L METTL23 DPPA3 TET3 H2AB1 H2AC8 H2AC6 H2AC7 CNOT4 CNOT6 KDM5B CNOT7 TNKS1BP1 CNOT1 TP53 CNOT2 CNOT3 SRPK1 CNOT8 CNOT9 H2AC19 H2AC14 H2BC12L TUT7 PABPC1 KDM4E TUT4 H2BC26 BTG4 H2BC21 TPRX1 DUX4 ZFP36L2 PABPN1L LEUTX TPRXL EP300 DPPA4 DICER1 TPRX2 H2BC17 DPPA2 ZSCAN4 DUXA DIS3L2 H2BC12 DUXB H2BC13 H2BC14 H2BC15 PRM2 PAIP1 PRM1 CREBBP NPM2 CNOT10 H1-8 H2BC11 CNOT11 H4C9 H2AZ2 H2AC20 PABPN1 AGO2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling UBE2L6 IFIH1 HERC5 RNF135 TBK1 TRIM25 ITCH IRF3 UBE2K MAVS UBA52 UBE2D1 RIGI PIN1 TRAF3 UBB IKBKE TAX1BP1 UBC ISG15 RPS27A UBA7 ATG12 NLRX1 ATG5 RNF125 RNF216 TRIM4 NLRC5 PCBP2 UBE2D2 OTUD5 TNFAIP3 UBE2D3 CYLD TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases CRADD ATM CASP1 TP73 PIDD1 TP63 TP53 CASP6 CASP10 CASP2 APAF1 NLRC4 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT6A CCT8 TCP1 CCT7 ACTB CCT5 CCT4 CCT6B CCT3 CCT2 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 NUP37 NUP107 GEMIN2 PHAX SNRPD2 SNRPD1 SNRPD3 PRMT5 WDR77 NUP160 CLNS1A SNRPG GEMIN4 GEMIN5 SNRPE NUP85 GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 TGS1 SNUPN SEC13 NUP133 NUP205 POM121 NUP188 AAAS RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions UBE2L6 HERC5 IFNAR1 CCNC UBA52 ELOB GPC1 BECN1 ELOC TYK2 GPC3 JAK1 GPC2 GPC5 GPC4 STAT2 GPC6 MED9 UBB CD14 MAP1B MED8 UBC AGRN MED4 MED6 RPS27A CDK19 MED7 RBX1 MED16 MED15 MED17 MED12 MED14 IFNB1 MED13 MED30 MED10 MED31 CLEC4M IFNA5 MED27 IFNA4 MED26 IFNA7 IFNA6 IFNA1 MED23 IFNA2 MED25 IFNA8 MED24 IFIH1 MED20 TRIM25 IRF3 IFNA21 CDK8 IFNA14 IFNA16 IFNA17 MAVS MED19 IFNA10 MED18 RIGI MED11 HSPG2 MED29 CX3CR1 MED28 MED22 MED21 SDC4 SDC2 SDC3 LY96 TLR7 TLR3 EIF2AK2 ISG15 CUL5 CD209 EP300 TLR6 SDC1 TLR2 MED1 H2BC15 CREBBP MED13L OAS2 ARIH1 TLR4 BCAP31 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2I PTBP1 POLR2J POLR2K POLR2L GTF2F1 GTF2F2 NCBP1 NCBP2 HNRNPM HNRNPA1 HNRNPH1 HNRNPF TIAL1 TIA1 RBFOX2 ESRP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ESRP1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex BCL7A BCL7C BCL7B DPF2 SS18 SMARCB1 SMARCD1 SMARCD2 BCL11B PHF10 ARID1A ACTB SMARCA4 SMARCC1 SMARCD3 SMARCC2 ACTL6A SMARCE1 BCL11A FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SS18 SMARCB1 SS18L1 SMARCD1 ARID1A SMARCA2 ARID1B ACTB SMARCA4 SMARCC1 ACTL6A SMARCE1 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP TTF1 UBTF POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H TAF1D POLR1C TAF1B TAF1C TAF1A POLR1D CAVIN1 CCNH POLR2E POLR2F POLR2H SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 B3GNT5 CHST4 GCNT1 CHST10 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 GALNT2 A4GNT GALNTL5 SLC35A1 GALNTL6 B3GNT3 LARGE2 POMT2 SEMA5A GALNT12 SPON2 SEMA5B SPON1 FKTN THSD7B SLC35A4 POMT1 FKRP ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 MUC13 THSD7A MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 POMGNT1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 B4GALT6 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 B4GALT5 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 MUC16 MUC17 C1GALT1 MUC19 SSPOP POMGNT2 MUC5B MUC20 MUC21 POMK MGAT5B B3GALNT2 ST6GALNAC2 ST3GAL4 CRPPA ST3GAL1 GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 DAG1 ST6GALNAC3 ST6GALNAC4 POFUT4 POFUT2 POFUT3 MMRN1 THBS1 B4GAT1 RXYLT1 EMID1 B3GNT7 B3GNT4 MMRN2 B3GNT2 GALNT11 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS HRAS NTF4 SOS1 NTRK2 NRAS BDNF CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation NARS1 CARS1 VARS1 DARS1 WARS1 LARS1 SARS1 EEF1E1 KARS1 GARS1 IARS1 AIMP1 AIMP2 QARS1 EPRS1 PPA1 TARS1 AARS1 HARS1 RARS1 FARSA FARSB MARS1 YARS1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation SERPINA1 CTSC MAGT1 HSPA6 ARSA RAC1 TCIRG1 FTH1 CD59 TRAPPC1 ATP6V0C FTL TCN1 CAND1 ACTR1B CTSH ATP6V1D HMOX2 ATP6V0A1 EEF1A1 LCN2 C5AR1 EEF2 ADAM10 VCP CHRNB4 NAPRT PDXK STK10 ALOX5 C3 SNAP23 DDOST SERPINB6 PLAU STOM MGAM CYBB JUP CYBA DIAPH1 CHIT1 NCKAP1L CKAP4 PTPN6 FCER1G AP2A2 GPR84 TOLLIP TNFRSF1B SLC2A5 NPC2 ACAA1 PSEN1 NCSTN SLC27A2 BIN2 A1BG MMP25 CEACAM6 SERPINA3 ORM1 CEACAM8 ORM2 QSOX1 AHSG IDH1 ADAM8 CD63 C3AR1 ARHGAP9 GOLGA7 MMP8 CTSG GNS PECAM1 PYCARD LRRC7 CCT2 DERA OLR1 CEACAM3 CDA PYGB CD58 SIRPA PYGL ARPC5 FAF2 BST2 SELL RHOF ACTR2 MANBA FGR CCT8 GAA PGAM1 TUBB4B FCGR2A ARHGAP45 ALDOC ALDOA PPIE FRK CD44 DDX3X SIRPB1 DYNLT1 MMP9 DBNL AGL MOSPD2 GYG1 SIGLEC9 HVCN1 GDI2 LILRA3 HSPA1B LAIR1 CLEC5A RAB31 LILRB2 LILRB3 GSN SIGLEC5 OSCAR MAN2B1 HPSE RAB18 B4GALT1 KPNB1 HLA-H HK3 HLA-C PGM2 PGM1 TLR2 HSP90AA1 DNAJC3 LTF PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 GALNS PFKL PSMA2 ALAD PSMD12 PSMD11 HSPA1A PSMD14 PSMD13 HLA-B TICAM2 PSMB7 ACTR10 PAFAH1B2 CD14 PSMB1 NFKB1 VNN1 PSMC3 PSMC2 PTPRC CD33 SLC15A4 CD300A S100A12 AMPD3 NDUFC2 APRT PNP CD177 TYROBP CD36 RAB27A ATP8A1 CLEC4C ITGAL CLEC4D ATP11B ATP11A SRP14 APAF1 PRDX6 GSTP1 TRPM2 MIF CNN2 ATP8B4 CYB5R3 SLCO4C1 ANO6 LGALS3 B2M AP1M1 CEP290 APEH TUBB LPCAT1 SLC11A1 NRAS AGPAT2 RAP1A MAPK1 P2RX1 MAPK14 DSC1 PKM ARG1 PLAC8 HBB CEACAM1 RHOA ASAH1 CYFIP1 RAB10 RAB14 LAMP2 ILF2 STBD1 RHOG PPIA CAT RETN DOCK2 RAB7A PLD1 IQGAP2 PRTN3 HGSNAT VAPA AOC1 CAPN1 RAB6A IST1 IGF2R SLC44A2 RAB9B TBC1D10C S100A9 S100A8 DGAT1 FRMPD3 GMFG ABCA13 ADGRE5 PGLYRP1 FUCA1 FABP5 NHLRC3 MCEMP1 ADGRE3 RNASE3 CDK13 SCAMP1 RNASE2 ITGAM UNC13D ITGB2 FLG2 PADI2 GPI CRACR2A PRDX4 S100A11 AZU1 PA2G4 ITGAX HRNR PIGR SERPINB3 CD47 SERPINB1 NFAM1 TMT1A ITGAV ANXA2 TMC6 PLEKHO2 SERPINB10 GRN NME2 SERPINB12 AGA ERP44 LRG1 RAB5B IMPDH1 YPEL5 RAB5C GHDC TMEM179B IMPDH2 EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A CAP1 S100A7 FCGR3B BRI3 PTPRB HSP90AB1 NIT2 ROCK1 FCAR CD55 GM2A ACP3 RNASET2 TMBIM1 CANT1 FGL2 PRCP CPPED1 BST1 MNDA FOLR3 VPS35L CALML5 C6orf120 KRT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 VAT1 PTPRN2 CTSD SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 CYSTM1 PTPRJ GLIPR1 CAMP CD53 FPR1 RAP2C RAP2B DNASE1L1 CSTB PGRMC1 CREG1 KCNAB2 ORMDL3 GCA PTGES2 SVIP QPCT CD68 MPO COTL1 ENPP4 OSTF1 CD93 IRAG2 ATAD3B DOK3 ADGRG3 HEXB NEU1 DPP7 ALDH3B1 GGH CAB39 DNAJC13 TARM1 CTSA DEGS1 MS4A3 TNFAIP6 CRISP3 HEBP2 LAMTOR2 CHI3L1 GLB1 LAMTOR1 CLEC12A MVP LAMTOR3 TMEM30A CMTM6 RAB3D PDAP1 RAB44 S100P GUSB PTX3 SNAP25 ARSB GLA SPTAN1 PSAP RAB37 RAB4B CTSZ COMMD9 NFASC COMMD3 TXNDC5 RAB24 HSPA8 VAMP8 DYNC1LI1 MLEC PPBP DSN1 RAB3A HMGB1 CR1 CFP CXCR1 DYNLL1 DNAJC5 COPB1 CXCR2 PLAUR SDCBP ELANE GSDMD MGST1 CXCL1 DYNC1H1 ARMC8 FPR2 CPNE1 CPNE3 ATG7 DSP DSG1 HUWE1 ACLY PKP1 CST3 TTR LYZ SNAP29 PTAFR TSPAN14 TIMP2 DEFA1B PRSS3 PRSS2 DEFA4 ADA2 SLC2A3 PRKCD HP ANPEP MME ATP6AP2 FUCA2 CTSS CTSB FCN1 CSNK2B CFD UBR4 IQGAP1 BPI SURF4 RAP1B VCL XRCC6 LTA4H XRCC5 STING1 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n RFT1 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLRB2 IFT70B DYNLRB1 IFT70A IFT25 DYNLT2B IFT74 DYNC2I2 IFT52 DYNC2I1 TRAF3IP1 IFT172 WDR19 KIF17 KIFAP3 DYNC2H1 TNPO1 IFT57 TRIP11 IFT80 IFT56 IFT88 CLUAP1 IFT81 DYNLT5 DYNC2LI1 DYNLT2 KIF3B IFT140 KIF3A TTC21B DYNLL1 KIF3C WDR35 DYNLL2 IFT43 IFT122 IFT20 IFT22 IFT46 IFT27 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME SULT1E1 GGT3P SULT1A4 ABCC4 SULT1A3 GSTM1 SULT2A1 ABCC5 SULT1C4 GSTT1 CNDP2 CYP2E1 UGT1A10 GGT1 UGT2B15 ACY1 GSTP1 NAT1 NAT2 GGT5 ABCG2 UGT1A1 ABCC2 UGT1A9 ABCC3 UGT1A6 ABCC1 GGT7 GGT6 SULT1A1 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) DHCR7 SC5D EBP DHCR24 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MTFMT MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MTIF2 MRPL46 MTIF3 MRPS6 MRPS5 MRPL43 MRPL44 MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins SCP2 PHYH TYSND1 HSD17B4 ACAA1 ACOX1 AGPS LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis SLC2A1 LALBA B4GALT1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 EP300 HNF1B RBPJ MAML2 CREBBP MAML1 NEUROG3 KAT2B KAT2A MAMLD1 SNW1 HES1 ONECUT3 ONECUT1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB PRKAR2B CALM1 PRKACA PRKACG ADCY4 NBEA PRKACB ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A ADCY9 PRKAR1B BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants ALK GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis NECAP1 CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SNX5 NAPA TBC1D8B SNAPIN AP1G1 SORT1 DTNBP1 AP1S2 PUM1 AP1B1 TPD52L1 AP1S1 GOLGB1 AP1S3 YIPF6 TGOLN2 ACBD3 TFRC AP1M2 AP1M1 FTH1 IGF2R CLINT1 SH3GL2 FTL VAMP2 ARF1 AP4E1 BLOC1S1 AP3B1 TXNDC5 HSPA8 AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 RAB5C SNX9 ARRB1 PICALM PIK3C2A OCRL GAK HIP1R INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption RSC1A1 SLC2A2 SLC5A1 SLC2A5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC1A5 SLC7A11 SLC6A20 SLC7A10 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC36A4 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC6A6 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GGCX GP5 F11 GP1BA F9 F8 GP9 F10 GP1BB DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere H2AX CENPT CENPU CENPH CENPI HJURP CENPK RSF1 CENPL MIS18BP1 CENPM OIP5 CENPN CENPW CENPX CENPO MIS18A CENPP H2AJ CENPQ CENPS H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 KNL1 NPM1 H2AC19 H2AC14 H2BC12L SMARCA5 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RUVBL1 H4C9 RBBP4 ITGB3BP RBBP7 H2AZ2 CENPA H2AC20 CENPC DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus RB1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P RPIA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TAB3 TAB2 TAB1 UBA52 IRAK2 TICAM2 TICAM1 TLR4 LY96 UBB TRAF6 CD14 UBC RPS27A MAP3K7 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis TNFRSF10B TNFRSF10A ITCH FAS FASLG UBA52 STUB1 OGT UBB MLKL UBC RPS27A TRADD UBE2L3 CASP8 FLOT1 TNFSF10 FLOT2 PDCD6IP RIPK3 TRAF2 HSP90AA1 CDC37 PELI1 BIRC2 BIRC3 PRKN XIAP SDCBP RIPK1 FADD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing SNU13 SNW1 SNRPD2 SNRPD1 SNRPD3 TCERG1 SNRPG SNRPC SRSF8 SNRPA HTATSF1 SNRPE RBM25 SNRPF SNRNP70 PRPF40A SNRPB PPP1R8 SRSF10 SRSF12 MTREX RBM39 PPIL2 NCBP1 NCBP2 PQBP1 SRRT LSM5 LSM4 LSM3 SNRNP200 LSM2 LSM7 FUS LSM6 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA3 TRA2B GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC DHX16 RBMX HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 SAP18 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD STEEP1 SF3B4 GPATCH1 SF3B5 PNN SF3B2 SF1 SF3B3 DHX8 SF3B6 PRKRIP1 SF3B1 CWF19L2 SF3A3 WDR70 SF3A1 DHX35 SF3A2 PRPF38A XAB2 SMU1 PHF5A NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A TXNL4A CACTIN SNRPN PRPF31 RBMX2 CHERP SNIP1 IK PRP4K LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 PTBP1 YJU2 PLRG1 LSM8 SNRPA1 PPWD1 DNAJC8 USP39 SART1 PUF60 TFIP11 SNRPB2 SYF2 C9orf78 LUC7L3 PPIL1 NSRP1 SNRNP40 WBP4 RNF113A MFAP1 RBM42 BUD13 PPIL3 PPIL4 FAM50A SRRM2 AQR CRNKL1 PRPF19 HNRNPH1 HNRNPH2 CWC25 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 RBM7 HNRNPU EIF4A3 CASC3 MAGOH CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D DDX39B POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 GTF2F1 RBM8A GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ACIN1 ALYREF UPF3B MAGOHB RNPS1 DDX41 ZNF830 DHX9 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins TEX101 NEGR1 DPM1 DPM2 DPM3 XPNPEP2 GPLD1 GP2 PRSS21 CD109 PRSS41 VNN1 VNN2 TECTA TECTB GPIHBP1 PGAP1 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 PLET1 CPM PSCA LY6E RTN4RL2 LYPD6B PIGS PIGU PIGT PIGO RTN4RL1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGK FOLR2 PIGM PIGL PIGG PIGF PIGH OTOA LY6K RAET1G RAET1L LY6D IZUMO1R LY6H CEACAM7 NRN1L SPRN CEACAM5 FCGR3B SPACA4 MDGA2 LY6G6C MELTF RECK LY6G6D MDGA1 MSLN NRN1 ART3 ART4 LSAMP NTNG1 NTNG2 BST1 GPAA1 CD52 NTM ULBP2 PRND CNTN5 ALPL CNTN3 PLAUR CNTN4 ALPG ALPI OPCML SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function PPP1CC SHOC2 ARAF PPP1CB RAF1 BRAF YWHAB MRAS NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 NEURL1 YBX1 EGFR UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B NOTCH3 MIB2 EGF TACC3 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism NUDT19 ACBD5 PHYH SLC25A17 ACOXL ACOX2 ACOX3 ACBD4 HACL1 HAO2 ACOT8 EHHADH HSD17B4 NUDT7 ACAA1 PECR AMACR DECR2 ABCD1 SLC27A2 CRAT CROT ACOT4 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME AKR1C1 CYP3A4 UGT2B17 HSD11B1 HSD11B2 ALB SERPINA6 UGT1A3 ABCB1 UGT2B7 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle ARHGAP12 GIT2 EPHA2 WASL PARD6B ARHGEF7 CCP110 PAK4 CEP97 SPTBN1 PEAK1 PARD6A ZNF512B VANGL1 USP9X PAK6 PAK1 SH3RF1 SPTAN1 IQGAP1 PAK2 CLTC PIK3R1 NCK2 GIT1 NCK1 TXNL1 TPM4 TPM3 RHOV CDC42 WDR6 MYO9A DST MAP3K11 DEPDC1B DLG5 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs POLR2I H2AC6 POLR2J H2AC7 POLR2K H2AX POLR2L TNRC6A RAN H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 IPO8 H2BC1 H4C9 POLR2A POLR2B POLR2C H2AB1 POLR2D H2AZ2 POLR2E H2AC20 POLR2F AGO1 POLR2G AGO2 POLR2H H2AC8 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants ALK NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions KIRREL3 ACTN3 KIRREL1 KIRREL2 MAGI2 WASL SPTAN1 PIK3R2 IQGAP1 PIK3R1 PIK3CA NPHS1 ACTN1 NCK2 NCK1 ACTN2 SPTBN1 ACTN4 FYN PIK3CB CD2AP CASK CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism SLC44A2 BHMT SLC22A4 DMGDH CHDH SARDH ALDH7A1 SLC44A1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell SCUBE2 SHH GPC5 NOTUM IHH ADAM17 DHH DISP2 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway POLB OGG1 XRCC1 LIG3 NEIL2 NEIL1 PNKP ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 DGAT2L6 AWAT2 DGAT2 DGAT1 MGLL PNPLA2 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles FMO1 FMO2 FMO3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex CHUK PELI1 UBE2N IRAK1 IKBKB UBE2V1 TRAF6 PELI3 PELI2 IKBKG DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling ITCH UBB UBA52 SRC NEDD4 UBC RPS27A WWP1 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants STAT5A STAT5B PIM1 GAB2 NOX4 GRB2 SOS1 CDKN1A PIK3R1 PIK3CA NRAS HRAS FLT3 BCL2L1 PTPN11 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism ORMDL3 CSNK1G2 ST6GALNAC5 STS ARSA NEU2 NEU3 B3GNT5 SUMF2 SUMF1 NEU1 HEXB ALDH3B1 ST8SIA5 HEXA ST3GAL5 GLB1L3 CTSA DEGS1 GLB1L2 ARSL GLB1L GLB1 ARSJ ARSK ARSH ARSI ARSF ARSB GLA ARSG ARSD PSAP ABCG2 FUT2 FUT1 B3GALT4 M6PR CYB5B SMPD3 SMPD2 CERK ASAH1 GBA3 GBA2 OSBP MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 B4GALT6 PLPP3 PLPP2 PLPP1 UGCG UGT8 ALDH3B2 SGPL1 B4GALT5 B4GALNT1 ST6GALNAC6 KDSR B3GALNT1 ACER2 FA2H ACER1 ACER3 DEGS2 GAL3ST1 SPTLC1 SMPD4 SPTLC2 SPTLC3 A4GALT CERS3 CERS4 CERS5 CERS6 SPHK2 CERS1 CERS2 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB SPTSSA ORMDL1 SGPP2 SGPP1 GALC VAPA VAPB GBA1 ABCC1 SMPD1 ST3GAL2 ST3GAL3 GM2A SPHK1 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC MUC1 MUC2 MUC12 MUC7 MUC13 MUC4 MUC6 GALNT3 MUC15 MUC16 MUC17 MUC19 MUC5B MUCL1 MUC20 MUC21 MUC3A MUC5AC MUC3B METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids HSD17B1 STS CYP24A1 SRD5A3 OSBPL1A TM7SF2 GGPS1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK INSIG2 SAR1B INSIG1 CYP19A1 ACACB ACACA SREBF1 PMVK SCAP SC5D FDFT1 FDPS LHB MBTPS1 SLCO1B1 SEC24B SLCO1B3 SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SEC24D KPNB1 HSD11B1 SEC24C HSD11B2 SMARCD3 MBTPS2 SERPINA6 CHD9 ABCB11 HELZ2 LBR OSBP TGS1 TBL1X CYP11A1 NCOA1 MED1 GC NCOA2 CREBBP NCOA6 TSPOAP1 CYP2R1 HSD3B7 AKR1C1 AKR1D1 NR1H4 TBL1XR1 AKR1C2 AKR1C4 CARM1 CYP7B1 CYP7A1 CYP27A1 LRP2 SRD5A2 SLCO1A2 SRD5A1 CYP17A1 LDLRAP1 RAN CH25H CUBN OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 AKR1B15 HSD17B14 HSD17B11 HSD17B2 ACOT8 HSD17B4 SLC27A2 HSD17B3 HSD17B12 CYP8B1 STARD3 STARD4 STAR STARD6 FASN IDI2 STARD3NL MSMO1 TSPO HSD17B7 ACAT2 NSDHL BAAT STARD5 ARV1 EBP SLC10A1 ACOX2 SLC10A2 DHCR24 PIAS4 SLC51A PLPP6 SLC51B SLC27A5 POMC UBE2I VDR ALB FABP6 AMACR RXRA SUMO2 CGA PPARA AKR1C3 FDX1 FDXR FDX2 LGMN HSD3B2 CYP11B2 CYP46A1 CYP21A2 CYP39A1 HSD3B1 CYP27B1 CYP11B1 AKR1B1 ABCC3 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling PTPN4 MAPK8 SQSTM1 STAT3 MAP2K1 IL4 PTPN12 IL18RAP IL13 MAP3K8 TBK1 UBE2V1 NFKB2 HMGB1 ALOX5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 CASP1 IL1RAPL1 IL18 TRAF2 IL1A IL1B PELI1 PSMD8 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PSMD3 PSMD1 IKBKG BTRC PTPN11 MAP3K7 SKP1 GSDMD CHUK PTPN6 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 APP IL1RN PSMA1 PSMA2 UBA52 TOLLIP PSMD12 IL1R2 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 MYD88 PSMA7 RELA IL36A PSMB6 IL36B PSMB7 PSMB4 PSMB5 UBB IL36G IL1F10 PSMB2 NKIRAS1 PSMB3 UBC NKIRAS2 IKBIP PSMB1 RPS27A ADRM1 NFKB1 SEM1 IRAK4 NFKBIA RBX1 PSMC5 PSMC6 PSMC3 PSMC4 LRRC14 PSMC1 USP14 IL33 PSMC2 NLRX1 MAP3K3 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER IL36RN USP18 IRAK2 S100A12 IL1RL1 N4BP1 IL1RL2 S100B TNIP2 SAA1 PTPN18 IL37 PTPN20 PTPN23 SMAD3 PTPN13 PTPN14 IL18BP SIGIRR PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 IRAK3 CTSG TP53 TIFA ALPK1 MAP2K4 MAP2K6 IL1R1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 PRKCZ NRAS REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity GJA1 TJP1 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud GREM1 GDNF EYA1 ITGB1 FOXC2 FOXC1 SIX1 HOXD11 SLIT2 HOXC11 HOXA11 SALL1 SIX2 ROBO2 WNT11 RET GFRA1 NPNT PAX2 BMP4 ITGA8 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity KNG1 A2M PLAUR HRG C1QBP KRT1 F12 SERPING1 KLKB1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors TP63 PHF20 TP53 ZNF385A POU4F1 POU4F2 PPP1R13B TP53BP2 BANP TP73 AKT2 PPP1R13L AKT3 AKT1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation DNM2 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 GJB3 AP2M1 GJB6 GJB5 GJB7 GJD4 GJD3 CLTCL1 GJC1 GJD2 GJA10 MYO6 DAB2 CLTC DNM1 CLTA TJP1 GJA1 GJB2 GJB1 CLTB NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF5 TIAM2 OBSCN ARHGEF4 ARHGEF7 ARHGEF26 NGEF ARHGEF6 FGD1 FGD2 RAC1 KALRN GNA13 FGD3 FGD4 BCL2L11 ARHGEF33 ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 AATF VAV1 MAPK8 NGFR TIAM1 NGF SOS1 VAV3 VAV2 RASGRF2 ARHGEF18 ARHGEF10L BAD AKAP13 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 ECT2 PREX1 SOS2 MCF2L NET1 ABR ARHGEF16 ARHGEF40 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC MMACHC GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking DNM2 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 GJB3 AP2M1 GJB6 GJB5 GJB7 GJD4 GJD3 CLTCL1 GJC1 GJD2 GJA10 MYO6 DAB2 CLTC DNM1 CLTA GJA1 GJB2 GJB1 CLTB NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 NCBP1 NCBP2 UPF1 RPS27A EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 GSPT2 RPL29 GSPT1 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 PABPC1 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 ETF1 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases GSDMD CASP3 CALM2 CASP5 CASP4 CALM1 SERPINB1 IL18 IL1B CALM3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR PPP2CA SPRED2 PPP2CB SPRED1 UBA52 NCBP1 NCBP2 UBB UBC RPS27A CBL HNRNPM HNRNPF TIAL1 TIA1 RBFOX2 ESRP2 NRAS GAB1 FRS3 MAPK1 HRAS MAPK3 PLCG1 POLR2A FRS2 POLR2B POLR2C BRAF POLR2D POLR2E POLR2F POLR2G ESRP1 FLRT2 POLR2H FLRT1 POLR2I PTBP1 POLR2J POLR2K PPP2R1A POLR2L SOS1 TGFBR3 GTF2F1 GTF2F2 ANOS1 GIPC1 FGFRL1 FLRT3 KLB FGF1 FGFBP1 FGF2 FGFBP2 FGF3 FGFBP3 FGF4 FGF6 FGF7 FGF9 FGF20 HNRNPA1 HNRNPH1 FGF23 FGF22 FGF16 MKNK1 FGF19 FGF18 SPRY2 PIK3CA PIK3R1 FGFR4 FGF10 GALNT3 PTPN11 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 PROS1 PROC F5 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation AP2B1 ATP6V1H CD8B AP2A1 AP2S1 AP2A2 AP2M1 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 DLD PDP2 GSTZ1 PDHB CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 PRKCG KPNA2 ADCY9 PRKAR1B SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants HRAS KRAS NRAS SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) CTNNB1 PAX6 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 FFAR4 LEP FFAR1 GCG GNG13 GRP GPR119 GNB1 TCF7L2 GNAT3 DPP4 GNB3 CDX2 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease STAT5A STAT5B SOS1 KIT PIK3R3 PIK3R2 PIK3R1 PIK3CA LCK JAK2 STAT1 NRAS LYN STAT3 HRAS YES1 FYN SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 H2AX RAC1 MTMR1 H3-3B TFRC H3C8 VAV1 H2AJ SCFD1 H3C15 ATP6AP1 PAK1 PAK3 PAK2 KLC1 VHL KLC4 H2BC9 KLC3 H2BC8 KLC2 H2BC5 DOCK3 H2BC3 FRS3 H2BC1 TIAM1 HMOX2 H2AB1 H2AC8 H2AC6 H2AC7 JAG1 VCP ITSN2 DBT RTKN SOWAHC ARHGEF10L STK10 AKAP13 SLK H2BC26 H2BC21 ARHGEF11 ARHGEF10 NCKAP1 ARHGEF12 NCF1 YWHAG ARHGEF17 STARD8 NCF2 NCF4 RHOB PDPK1 CIT SNAP23 H2BC17 DAAM1 BRK1 ARHGAP6 ARHGEF3 H2BC12 ARHGEF1 DOCK10 H2BC13 ARHGEF2 SYDE1 H2BC14 PKN3 ARHGAP42 H2BC15 PIK3CA BAIAP2L1 ARHGEF25 PICALM RAC3 ARHGEF28 IQGAP3 LCK GIT1 SWAP70 STOM RHPN2 ARAP2 H2BC11 CYBB ECT2 STARD13 ARAP3 JUP OCRL CAVIN1 CYBA BCR CDC42 PCDH7 AMIGO2 MYO9A NET1 CTTN NOXO1 ANLN ARHGAP17 ARHGAP15 DIAPH1 ABR CSK ACTC1 RACGAP1 DLC1 PKN2 SLITRK3 PKN1 NHS H2AZ2 TNFAIP1 SLITRK5 RND3 NCKAP1L CKB WASF1 SEMA4F WASF2 ARHGEF40 CKAP4 NISCH PLEKHG2 IL32 KCTD13 GIT2 ARHGEF15 PLEKHG5 TRIP10 ARHGAP26 BAIAP2 ARHGEF19 TAOK3 RHOC ABI2 TIAM2 OBSCN NOXA1 ABI1 ARHGEF4 NOX3 ARHGEF7 NGEF NOX1 FERMT2 ARHGEF6 FGD1 C1QBP FGD2 GNA13 FGD3 FGD4 ARHGEF39 PLXNB1 SLC1A5 KLK3 KLK2 KDM4C RHOU GJA1 ACTB PTK2B CYFIP2 WIPF1 SCAI WIPF2 WDR91 WIPF3 ANKFY1 WDR81 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 LRRC1 ARHGAP4 BTK GMIP CDC42EP5 CDC42EP4 CDC42EP3 ARPC1B CDC42EP2 ARPC1A FGD5 CFL1 CHN2 WASL CHN1 FARP1 DEF6 WDR11 VMA22 WAS SHKBP1 GOPC ROPN1 FILIP1 TAX1BP3 FAM13B NF2 CCT6A FAM13A PRC1 POTEE GOLGA8R RALGAPA1 FAM91A1 TEX2 ARMCX3 DDRGK1 TUBA1B NSFL1C ARHGAP11A ZNF512B ARHGAP11B TAGAP CCT2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 MYH9 ARFGAP2 BLTP3B NCKIPSD DVL1 SH3BP1 DVL2 WHAMM DVL3 GOLGA3 BAIAP2L2 SPATA13 ARPC4 TMEM87A ARPC5 FAF2 ARPC2 AKAP12 ARPC3 HINT2 CTNNA1 GRB7 SH3PXD2A STMN2 RHOH ACTR3 KIF14 RHOF ACTR2 RHOD RND1 STIP1 RHOV EPSTI1 PLEKHG4B WDR6 EMC3 CCT7 PLXNA1 PRAG1 PLXND1 WASF3 SYDE2 FAM83B ANKRD26 ARHGAP44 DST DOCK11 RRAS2 BCAP31 ARHGAP40 BASP1 ALDH3A2 TMEM59 RALBP1 CCDC88A KCTD3 PREX2 MYL9 FAM135A ARHGAP45 VANGL2 ARHGAP19 ARHGAP18 UBXN11 AAAS TOR1AIP1 DLG5 CPD ARHGAP12 WWP2 PKP4 ARHGAP22 ARHGAP20 RHPN1 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 SFN ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 LIN7B RASGRF2 USP9X ARHGEF9 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 FMNL3 HSP90AA1 PRKCB ARHGAP39 SRGAP3 LIMK2 SRGAP2 LIMK1 SRGAP1 RHOT2 MYH14 MYH10 RAP1GDS1 MFN1 MFN2 MYO19 TRAK2 DOCK7 MRTFA SENP1 SRRM1 PTPN13 AR DDX39B TRAK1 PRKCA PIN1 CCP110 CEP97 ARHGAP10 SRF PLK1 SRC STAM CDH1 HGS CTNNB1 STAM2 YWHAB FARP2 MAPK1 PLD2 MAPK3 KIDINS220 FRS2 MAPK14 MAPK11 RAPGEF1 SOS1 PARD6B ARHGEF18 PRKCZ RHOA PARD6A XPO1 PGRMC2 ARL13B DDX4 ITGB1 CYFIP1 DOCK5 ANKLE2 DOCK4 TRIO NCOA2 ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L CFTR ARHGDIB EMD TMPO PLEKHG3 YWHAQ ARHGEF16 RHOG VRK2 LEMD3 ARFGAP3 DEPDC1B NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 CALM1 ARHGEF5 RAB7A EPHA2 YWHAE VAMP3 ARHGEF26 PPP1R12A GARRE1 SHMT2 PPP1R12B CDC25C PPP1R14A PLD1 IQGAP2 KALRN RHOBTB3 ARHGAP21 LMAN1 LMNB1 STX5 YKT6 PAK4 NDUFA5 MCF2 MCAM ERBIN YWHAH HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB RAB9A ESYT1 RAB9B YWHAZ PPP1CB ABCD3 RAC2 S100A9 S100A8 RHOT1 PLIN3 CAV1 VAV3 PTK2 PFN1 VAV2 FLNA PFN2 UACA HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 PAK6 MSI2 PAK5 RHOBTB1 MYO9B ACTG1 RHOBTB2 TRA2B MYO6 ABL2 STK38 RBBP6 RNF20 SPEN CPSF7 KDM1A TMOD3 NCK2 ACTN1 NCK1 TXNL1 COPS4 COPS2 EVL CDC37 PHIP SOS2 PDE5A VIM HNRNPC RBMX DBN1 CUL3 RASAL2 MEN1 SPTBN1 LAMTOR1 MYLK MYL12B CDKN1B SPTAN1 MYH11 ABL1 TPM4 TPM3 MYL6 CCNE1 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MTR MAD1L1 CDCA8 MUC13 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 DLG4 PIK3R4 RCC2 NDC80 ZWINT LBR KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 FLOT1 NDEL1 SEC13 NUDC FLOT2 NUP133 PIK3C3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SAMM50 SPC24 MAD2L1 CENPS NUP37 SPC25 MTX1 SH3RF1 STEAP3 LRRC41 DSP DSG1 DSG2 CAPZB TJP2 PRKCD KIF5B KIF5A H2AC19 H2AC14 H2BC12L PIK3R3 IQGAP1 PIK3R2 PIK3R1 H4C9 ZAP70 MAP3K11 H2AC20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis HSD17B1 AKR1B15 HSD17B14 HSD17B11 HSD17B2 CYP19A1 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers DKK2 H2AX DDX46 DDX42 RBM17 CHD8 MYOG MYOD1 TCF4 H3-3B SMNDC1 U2SURP H3C8 H2AJ CTNNB1 H3C15 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 H2BC9 SF3A1 H2BC8 SF3A2 H2BC5 ZMYND8 PCK1 PHF5A CHD5 H2BC3 IKZF1 IKZF2 PHF6 H2BC1 IKZF3 ZNF687 SNRPN TCF19 ZNF592 ZNF827 CHERP MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 SNRPA1 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 SNRPG CHD9 SNRPE SNRPF MBD3 SNRPB H2BC26 H2BC21 WDR5 EP300 GATAD2B GATAD2A H2BC17 H2BC12 CHD7 H2BC13 H2BC14 FBP1 NKD2 FAM124B H2BC15 CREBBP HDAC2 H2BC11 CBX1 TCF3 MAFK CHD4 RBBP4 CHD3 NFE2L2 RBBP7 H2AZ2 AXIN2 MTA2 CDC73 SUPT16H SKIC8 CTR9 RTF1 CHD2 LEO1 PAF1 SSRP1 MTA1 HDAC1 MTA3 UBE2I CBX3 SUMO1 G6PC1 TCF12 H2AC19 H2AC14 H2BC12L NR2C2 IGF2 NQO1 ADNP2 ADNP CTCF CHD1 CHD6 DHX15 H4C9 H2AC20 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL OFD1 CPAP TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion GNA11 GNAQ MARCKS GNA14 PRKCA PLCB3 GNA15 PLCB1 CHRM3 PLCB2 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus YWHAZ JAG1 ADAM10 DLL4 PSENEN PSEN2 NOTCH4 PSEN1 APH1A NCSTN APH1B DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type CSPG5 CSPG4 NCAN BGN DCN BCAN VCAN CHST14 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle MSI2 ACTG1 RHOBTB2 TRA2B MYO6 STK38 CUL3 TMOD3 ACTN1 TXNL1 HSP90AA1 CCT6A CDC37 PHIP CCT7 HNRNPC RBMX DBN1 SRRM1 HSP90AB1 DDX39B CCT2 TWF1 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MDM2 PSMA7 PSMB6 PSMB7 MTBP PSMB4 BANP PSMB5 UBB PSMB2 PSMB3 SRC UBC CTNND1 PSMB1 RPS27A ADRM1 CDH1 SEM1 CTNNB1 EPS15 PSMC5 CBLL1 PSMC6 PSMC3 PSMC4 PSMC1 RACK1 PSMC2 CTSL DNM2 CTSS CTSB CTNNA1 JUP PSMD8 PSMD6 PSMD7 PSMD2 VCL PSMD3 PSMD1 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage CDA UPP2 UPP1 TYMP TK2 TK1 MAPDA GMPR2 ADK HPRT1 AMPD1 GMPR AMPD2 AMPD3 DCK UCKL1 APRT UCK2 DGUOK UCK1 PNP PUDP ADA SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport GLTP ARF1 CPTP PLEKHA8 CLN3 ESYT3 ESYT2 ESYT1 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria DCXR INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism POM121C NUP42 NUP62 NUP43 TPR CALM1 NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 INPPL1 NUP155 PLD4 INPP5B NUP153 PLCZ1 INPP4A NUP93 INPP4B NUP50 INPP5D INPP5J NUP35 PLCE1 NUP54 ITPK1 ITPKB ITPKC PLCB4 MTMR9 SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 MTMR7 PLCD4 IPMK PLCD1 MINPP1 NUP37 IPPK NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K1 NUDT3 PLCG1 IP6K3 NUDT4 NUP107 MIOX ISYNA1 INPP1 INPP5A IMPA1 PLCG2 IMPA2 PLCB3 PLCB1 PLCB2 NUP160 PTEN NUP85 SEC13 NUP133 OCRL IP6K2 NUP205 POM121 NUP188 AAAS SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC35C1 POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 SLC22A5 NUP153 NUP93 SLC35A3 NUP50 SLC17A5 NUP35 NUP54 SLC1A1 SLC2A9 SLC24A1 SLC3A1 SLC2A2 SLC1A3 SLC40A1 SLC5A1 SLC3A2 SLC6A3 HEPH SLC35A1 SLC5A7 SLC6A20 NUP37 SLC67A1 SLC11A2 AVPR1B SLC6A19 AVPR2 SLC36A2 AVP AVPR1A SLC6A14 SLC26A2 SLC34A3 SLC34A2 SLC34A1 SLC7A7 SLC7A9 NUP107 SLC5A5 SLC17A8 GCKR CP SLC4A4 BSG SLC39A4 SLCO2A1 SLC27A4 SLC5A2 SLCO1B1 SLCO1B3 SLC33A1 SLC6A5 SLC9A6 SLC26A4 SLC26A3 SLC6A2 SLC9A9 SLC12A3 GCK SLC22A12 SLC2A1 SLC2A10 SLC12A1 SLC12A6 NUP160 SLC29A3 HK1 SLC24A4 SLC20A2 NUP85 SLC35A2 SLC16A1 SLC24A5 SLC4A1 RHAG SEC13 NUP133 NUP205 POM121 NUP188 AAAS TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE TICAM1 TLR3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation EP300 HSF1 RPTOR CREBBP FKBP4 HSPA1A CAMK2B HSP90AA1 HSPA1B CAMK2D HSPA1L CAMK2A HSPB8 AKT1S1 HSBP1 CRYAB PTGES3 HSPA2 HSP90AB1 CAMK2G HSPA8 MTOR DNAJB1 MLST8 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 HDAC3 HDAC1 HDAC2 NGF NGFR PRDM4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism ALAS2 ALAS1 FECH COX15 UROS CPOX PPOX SLCO1B1 ALAD SLCO1B3 UROD HMBS COX10 GSTA1 HMOX1 ABCG2 UGT1A1 ABCC2 FABP1 UGT1A4 ALB ABCC1 HMOX2 BLVRB BLVRA INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism TKT PRKAG2 STK11 KCNB1 KCNS3 SNAP25 PFKFB1 VAMP2 STX1A AGPAT1 RAP1A ACACB ACACA PPP2R1B PPP2R1A STXBP1 CACNA2D2 MLXIPL ADIPOQ SLC2A1 ADIPOR1 ADIPOR2 ADRA2C ADRA2A CACNA1C CACNB2 ABCC8 CACNB3 CACNA1A CACNA1E PPP2R5D PRKAA2 PPP2CA PPP2CB INS PRKACG PRKACB SLC2A2 MARCKS SYT5 MLX GLP1R FASN ACSL4 GNGT1 CHRM3 ACSL3 FFAR1 ACLY GNGT2 RAPGEF3 RAPGEF4 CACNA1D AHCYL1 ADCY9 PRKAR1B PRKAR2B CD36 PRKACA TALDO1 ADCY4 PRKCA PLCB3 ADCY3 PLCB1 PLCB2 ADCY2 ADCY1 GNAQ ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 GNG7 PRKAR1A GNG8 PRKAB2 AKAP5 KCNJ11 KCNG2 IQGAP1 GCGR GNA14 GNA15 GNA11 GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 KCNC2 GNB5 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR2L5 OR11G2 OR1J4 OR2L3 OR1J2 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR2L13 OR4X1 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 LDB1 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5D13 OR5AL1 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR8G5 OR5A2 OR4C16 OR6C3 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 EBF1 OR52L1 OR7D4 OR6B3 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2Z1 OR4D10 OR2A12 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 LHX2 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling PPP2CA FGF9 PPP2CB FGF20 FGF23 PPP2R1A FGF16 MKNK1 FGF18 SPRY2 UBA52 MAPK1 MAPK3 UBB FRS2 BRAF FGF1 FGF2 UBC PTPN11 FGF4 RPS27A CBL DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 OGG1 NTHL1 APEX1 TDG MBD4 SMUG1 MPG DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair RAD1 ATM RAD9B ATR RAD9A MSH6 SEM1 MSH2 MSH3 PMS2 MLH1 MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 RAD51B RAD51D OGG1 RAD51C DNA2 NTHL1 RHNO1 BLM NEIL3 RAD51AP1 NEIL1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A11 SLC22A8 SLC22A12 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling XAF1 PTPN6 IFNAR1 ADAR OASL KPNA1 OAS1 OAS3 IRF8 UBA52 IRF6 IRF9 ABCE1 SAMHD1 TYK2 JAK1 HLA-B HLA-A MX2 MX1 STAT2 UBB UBC RPS27A IRF5 PSMB8 IFNB1 SOCS3 USP18 STAT1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IRF3 IFNA21 IFNA14 IFNA16 IFNA17 IFNA10 IFITM3 IRF4 IFITM1 IFITM2 IFIT5 IFI35 IFIT1 KPNB1 IFIT3 HLA-H IFIT2 HLA-C HLA-F HLA-G HLA-E EIF2AK2 ISG15 RSAD2 IFI27 EGR1 RNASEL SOCS1 IFI6 IRF1 BST2 IRF2 IRF7 OAS2 IP6K2 GBP2 PTPN1 PTPN11 ISG20 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 NEIL1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium ARL3 RP2 CYS1 NPHP3 UNC119B UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes AMN CTRB1 LMBRD1 PRSS3 PRSS1 CBLIF ABCD4 CUBN TCN1 CTRB2 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 RAN NUP153 NUP93 NUP50 NUP35 NUP54 CPSF1 CSTF2 NUP37 CLP1 POP5 POP7 TSEN15 POP1 POP4 RTCB ZBTB8OS TSEN2 TSEN54 TSEN34 DDX1 C2orf49 RTRAF XPOT FAM98B NUP107 NUP160 TRNT1 NUP85 CPSF4 RPP30 RPP38 SEC13 RPP21 RPP25 NUP133 RPP40 ELAC2 NUP205 POM121 NUP188 AAAS RPP14 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation CHUK PELI1 UBE2N IRAK1 IKBKB UBE2V1 TRAF6 PELI3 PELI2 IKBKG DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 FGFR4 KLB PLCG1 FGF1 FGF2 FGF4 FGF6 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC7A7 SLC3A2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation UBE2N MAPKAPK3 TAB3 MAPKAPK2 TAB2 TAB1 IRAK1 UBE2V1 NOD1 NOD2 RIPK2 IRAK2 MAP2K3 TRAF6 MAPK14 IKBKG MAP3K7 MAP2K6 MAPK11 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling HLA-DRB3 HLA-DRB1 CD3G CD3E CD3D UBE2D1 INPP5D HLA-DPA1 HLA-DQB2 HLA-DQB1 TRBV12-3 PAK1 TRBV7-9 PAK3 PAK2 UBE2D2 TRAV8-4 HLA-DPB1 PLCG1 TRAC GRAP2 CDC34 PRKCQ UBE2V1 TRAV19 HLA-DRA PIK3CB UBE2N TAB2 PDPK1 PAG1 PIK3CA LCK PSMD8 IKBKB PSMD6 PSMD7 TRAF6 CSK PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK CD4 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 BCL10 RIPK2 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 TRAT1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTPRC PTPN22 PLCG2 WAS VASP PTEN TRBC1 ENAH PIK3R2 PIK3R1 NCK1 TRAV29DV5 HLA-DQA2 EVL HLA-DRB5 HLA-DRB4 ITK FYB1 PTPRJ ZAP70 LCP2 LAT CD101 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency MCCC2 PCCB ACACA MCCC1 HLCS PC PCCA APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEK2 BUB1B CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism ASAH2 ST6GALNAC5 STS ARSA NEU2 B3GNT5 NEU3 GALC SUMF2 SUMF1 HEXB NEU1 HEXA ST8SIA5 ST3GAL5 GLB1L3 CTSA GLB1L2 ARSL GLB1L GLB1 ARSJ ARSK ARSH ARSI ARSF ARSB GLA ARSG ARSD PSAP GBA1 FUT2 FUT1 SMPD1 M6PR B3GALT4 ST3GAL2 ST3GAL3 SMPD3 SMPD2 CERK ASAH1 GBA3 GBA2 GM2A ENPP7 B4GALT6 UGCG UGT8 B4GALT5 ST6GALNAC6 B4GALNT1 B3GALNT1 GAL3ST1 SMPD4 A4GALT SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells CBX6 PHC2 NFATC2 NFATC1 GATA3 PHC1 MTA2 CBX4 CBX2 ASH2L HDAC10 HDAC11 TNF JUN PHC3 MAML2 MAML1 MEN1 RUNX3 MAF BMI1 TPST2 RUNX1 RING1 FOS RNF2 NOTCH1 NOTCH2 MTA1 HDAC1 BATF MTA3 IL4R HDAC4 TBX21 SATB1 SMARCA4 CCL3 SNW1 IL4 IL13 KMT2A IRF4 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 IFNG DPY30 MBD3 WDR5 KLF13 STAT5A EP300 STAT5B GATAD2B TBL1X GATAD2A RBPJ POU2F2 HDAC5 HDAC2 CREBBP ETS1 POU2F1 HDAC8 STAT4 HDAC9 NCOR1 HDAC6 IL12RB2 TBL1XR1 HDAC7 CHD4 RBBP4 CHD3 RBBP5 YY1 IL5 RBBP7 STAT6 CBX8 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage TK1 CDA UPP2 UPP1 DCK UCKL1 TYMP UCK2 UCK1 TK2 PUDP PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation POLR2I POLR2J POLR2K POLR2L CCNK CCNT2 ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX BID BAX DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V GP5 VWF GP1BA GP9 GP1BB EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin HRAS SOS1 MMP3 PRKCA HBEGF EGFR NRAS COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport COG7 COG6 GOSR1 COG5 COG4 INS COG3 TMED2 COG2 ARF4 COG1 DYNC1I1 ANK2 ANK3 ANK1 NAPA DYNC1H1 NAPB ACTR1A GORASP1 DCTN6 GOLGA2 DCTN5 NAPG STX5 GOLGB1 SPTBN4 DCTN4 YKT6 SPTBN5 RAB1A SPTA1 TMED10 CAPZA3 ACTR10 COPZ2 SPTBN1 COPZ1 GOSR2 SPTBN2 RAB1B USO1 CD59 SPTAN1 SPTB KDELR3 DCTN1 FOLR1 BET1 ARF1 CAPZB BET1L NSF CAPZA1 CAPZA2 DCTN2 DCTN3 DYNC1LI1 DYNC1LI2 ARF5 ARCN1 GBF1 TMED3 TMED7 TMED9 CD55 KDELR2 ARFGAP2 KDELR1 COPG2 COPG1 COPB2 COPA DYNLL1 COPB1 TMEM115 DYNLL2 ARFGAP1 COPE DYNC1I2 ARFGAP3 ARF3 COG8 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway PRKCB PSMA5 AP2A1 PSMA6 PSMA3 AP2A2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PRICKLE1 RAC1 AP2M1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RYK UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 AP2S1 PSMC4 PSMC1 PSMC2 RAC2 AP2B1 CLTB WNT5A PRKCG SMURF2 SMURF1 PRKCA PFN1 WNT11 RHOA PARD6A WNT1 WNT4 FZD1 FZD3 DVL1 FZD2 DAAM1 DVL2 FZD5 WNT5B DVL3 FZD4 SCRIB ROR1 ROR2 FZD7 CLTC ARRB2 RAC3 CLTA FZD6 FZD8 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 VANGL2 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase AKAP9 CACNB1 CACNB2 CACNG8 KCNE1 CACNG4 KCNE2 KCNE3 KCNE4 CACNA2D2 KCNE5 KCNQ1 CACNA1C CACNG6 CACNG7 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors MAPK9 MAPK1 MAPK8 MAPK3 FOS JUN MAPK10 MAPK14 MAPK11 ATF2 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) OPN1LW RBP3 AWAT2 RLBP1 OPN1SW DHRS3 OPN1MW DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs CAMKK1 CAMKK2 CALM1 CAMK1 GIT1 RAC1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) FCGR1BP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 PSME1 SEM1 PSME2 PSMC5 PSMC6 PSMB10 PSMC3 PSMC4 PSMC1 PSMB8 PSMC2 PSMB9 MRC1 CD207 MRC2 FCGR1A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion PDS5A ESCO1 ESCO2 RAD21 WAPL STAG1 CDCA5 SMC1A STAG2 PDS5B SMC3 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation PRKAR2B PRKACA PRKACG ADCY4 PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ADCY5 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1A GCGR GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 ADCY9 PRKAR1B ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters SLC30A2 SLC39A4 SLC30A1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A5 SLC39A10 SLC39A14 SLC30A3 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2I POLR2J POLR2K POLR2L ELL SUPT5H CCNT1 GTF2F1 GTF2F2 ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease SOS1 UBA52 GOLGB1 SPTBN1 UBB TRIP11 UBC RPS27A CBL ETV6 STAT5A STAT5B PIM1 GAB2 NOX4 ZMYM2 GRB2 FLT3LG CDKN1A PIK3R1 PIK3CA NRAS HRAS MYO18A FLT3 BCL2L1 PTPN11 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway CDC42 PAK1 CD86 FYN PAK3 VAV1 CD80 PAK2 LCK RAC1 CD28 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events GPHA2 SRC GPHB5 LHCGR ADORA2A PTGDR LHB MC2R RLN2 RLN3 INSL3 RXFP1 RXFP2 PDE3B GRK3 FSHB GPBAR1 FSHR PTGER4 ITGB1 PTGER2 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 GPR84 PRKACG PDE2A PDE3A PRKACB GPER1 PDE8B PDE8A MC4R GRK6 PTGIR PDE4A PDE4D PDE4C PDE11A PDE10A PDE7B PDE7A GLP1R VIPR1 MC3R TSHR VIPR2 AVPR2 SCT AVP ADM PTH1R GNGT1 POMC GPR39 GNGT2 MC1R ADRB1 ADRB2 MC5R HTR4 GLP2R NPSR1 TAAR3P GNAT3 PTH2R HTR6 HTR7 NPS GIP ADCYAP1 ADCY9 HRH2 PRKAR1B DRD1 CRH IAPP P2RY11 ADCYAP1R1 PRKAR2B CGA RAMP2 CALCA DRD5 TSHB RAMP3 PRKACA TAAR8 CALCB TAAR9 CALCRL PTH TAAR6 PDE1B GIPR PDE1A GNAI3 GRK2 ADCY4 TAAR5 ADCY3 PTH2 TAAR2 PTHLH CRHR1 ADCY2 TAAR1 GHRHR ADCY1 ADCY8 GNG10 ADRB3 ADCY7 PRKAR2A ADCY6 GNG3 CALCR GNAI1 ADCY5 GNG2 GNAI2 GNG5 GRK5 GNG4 GNG7 PRKAR1A GNG8 CRHR2 CYSLTR2 GNAZ ARRB1 ITGA5 ARRB2 GCGR SCTR GCG GNG12 ADORA2B GNG11 GNG13 ADM2 GNB2 GHRH GNB1 GNAS GNB4 GNB3 GNB5 VIP RAMP1 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends RAD1 ATM RAD9B H2AX ATR RAD9A HERC2 UBA52 UBB CCNA2 CCNA1 UBC RNF4 RPS27A H2BC9 H3-4 PIAS4 H2BC8 H2BC5 H2BC3 UBE2I H2BC1 PPP4R2 CDK2 TIPIN SIRT6 TIMELESS BRCC3 PPP4C CLSPN TP53BP1 BABAM1 SUMO2 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 H2BC26 TOP3A UBE2V2 H2BC21 HUS1 UBE2N DNA2 MDC1 H2BC17 RHNO1 BLM H2BC12 H2BC13 H2BC14 H2BC15 WRN BRIP1 H2BC11 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 RAD50 RPA3 RAD17 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades CHUK BTK S100A1 CD36 TIRAP NFKB2 MYD88 RELA TICAM1 UNC93B1 LY96 TRAF3 CD14 TLR7 TLR3 HMGB1 NFKB1 IRAK4 NFKBIA TLR1 TLR10 TLR6 TLR5 TLR2 S100A9 S100A8 FGB FGA FGG IKBKB TLR4 IKBKG AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism MCCC2 MCCC1 PPM1K AUH IVD HIBCH GSTZ1 SHMT1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC KGD4 BCKDK BCKDHA DBT BCKDHB DLD GLUD1 GLUD2 SIRT5 TPH2 ASMT AANAT PXMP2 CKB SLC25A12 SLC25A13 GLS QARS1 HAL RIDA SDS AOC1 GAMT SDSL CARNMT1 SLC3A2 UROC1 AMDHD1 HDC CARNS1 RARS1 ACAD8 HNMT HIBADH FTCD PHYKPL ACADSB MARS1 ALDH6A1 SLC44A1 BCAT1 SLC44A2 SLC25A44 SEPHS2 BCAT2 SECISBP2 SLC36A4 EEFSEC SEPSECS DARS1 PSTK LARS1 INMT PIPOX SARS1 GNMT EEF1E1 SCLY KARS1 SLC6A12 ECHS1 IARS1 SLC7A5 AIMP1 AGXT AIMP2 PAOX DDO EPRS1 HAO1 CAV1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DAO DUOX1 CRAT TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 TP53 HSD17B10 SLC22A4 GCSH PAPSS2 PAPSS1 TPH1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 PNMT RPS14 RPS17 DDC RPS16 TH RPL18A DBH RPS19 RPS18 RPL36AL RPL36 ASNS RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 GLUL RPS8 NNMT MTRR RPL23 AHCY RPS5 RPL22 RPS6 MTR RPSA MAT1A SLC6A11 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 DMGDH RPL39L CHDH RPL41 SARDH ALDH7A1 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A GLYAT RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A GLS2 RPLP2 RPL13A GADL1 RPS3A APIP PSMD8 MRI1 RPL37A CSAD PSMD6 ADO RPL10 PSMD7 RPL12 TXN2 PSMD2 RPL11 CBS PSMD3 ENOPH1 RPL36A PSMD1 RPS27L MPST RPS15A GOT1 TXNRD1 TSTD1 GPT BHMT2 RPL14 RPS3 SQOR RPL13 GOT2 RPL15 FMO1 RPS2 SUOX BHMT PSMA5 RPL18 MTAP PSMA6 RPL17 PSMA3 TST ADI1 PSMA4 RPL19 PSMA1 RPL35A CTH ETHE1 PSMA2 RPL23A UBA52 RPL22L1 SLC25A10 FAU CDO1 PSMD12 PSMD11 RPL26L1 PSMD14 PSMD13 PSMA7 ACAT1 OCA2 PSMB6 SLC45A2 PSMB7 PSMB4 DCT PSMB5 TYRP1 TYR PSMB2 PSMB3 PSMB1 RPS27A SLC6A7 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 GLDC HYKK TDO2 CKMT1B HOGA1 IDO2 IDO1 GCDH OAZ1 OAZ2 ACMSD OAZ3 AFMID RIMKLA RIMKLB PYCR1 AGXT2 PYCR2 PYCR3 SLC6A8 KYAT3 PHGDH AASS ARG2 OAT HAAO ODC1 CKM QDPR IL4I1 AADAT PAH BBOX1 AGMAT PCBD1 KYAT1 GATM ASRGL1 SAT1 PSPH KMO SMS HGD AZIN2 AZIN1 TAT FAH GRHPR HPD SERINC1 SERINC3 SERINC2 SERINC5 SERINC4 SLC25A2 AMD1 ALDH4A1 DHTKD1 PRODH KYNU AMT PRODH2 ALDH9A1 SRM CKMT2 SRR SLC25A21 NQO1 CRYM TMLHE PSAT1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA OGDH DLST RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription BCL2L11 SMAD4 SMAD3 FOXO3 RUNX3 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer PPP2CA TNKS2 DKK1 PPP2CB DKK2 PPP2R1B DKK4 PPP2R1A AMER1 AXIN1 KREMEN1 CSNK1A1 KREMEN2 LRP5 LRP6 GSK3B CTBP2 CTBP1 CTNNB1 PPP2R5E FZD5 FZD4 WNT3A PPP2R5B PORCN PPP2R5A PPP2R5D FZD6 PPP2R5C APC FZD8 TCF7L2 RNF43 TNKS SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection POM121C NUP42 EZH2 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 TRIM28 NUP153 NUP93 NUP50 NUP35 NUP54 H3C8 HNRNPK H3C15 ELK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 DAXX H2BC1 NUP107 H2AC8 H2AC6 H2AC7 CEBPD DYNC1LI1 DYNC1LI2 EGFR NUP160 HDAC3 NUP85 H2BC26 CHMP1A H2BC21 EED TBL1X H2BC17 ITGB1 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 DYNLL1 H2BC11 CBX1 CHMP4C DYNLL2 CHMP4B NCOR1 TBL1XR1 CHMP3 CHMP4A CHMP6 RBBP4 CHMP7 RBBP7 DYNC1I2 PML NUP43 H2BC18 CHMP2B CHMP2A DYNC1I1 RANBP2 DYNC1H1 NUP37 NFKB1 H2AC17 H2AC12 NCOR2 H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 GPS2 TSG101 VPS4A MVB12B MVB12A VPS36 VPS37C VPS37D VPS37A H4C9 VPS37B SNF8 UBAP1 VPS25 VPS28 NUP205 POM121 H2AC20 NUP188 AAAS SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane MTMR14 PIK3C2G PIK3C2B INPPL1 SBF2 RUFY1 INPP4A INPP4B INPP5D PI4K2A INPP5J PIP4K2A PIP4K2B MTMR1 MTMR3 MTMR8 MTMR9 SYNJ1 MTMR6 MTM1 INPP5K PIP5K1A PIP5K1B PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PI4K2B MTMR2 RAB4A ARF1 PTPN13 RAB5A PTEN PIK3CD PIK3CB PIK3CG PIP5K1C SYNJ2 PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3R6 PIK3C2A PIK3R5 OCRL RAB14 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation RAD1 ATM AURKA RAD9B ATR PRKAG1 RAD9A PRKAG2 TP53RK STK11 UBA52 TAF7L CHEK2 PRKAG3 MDM2 MDM4 SUPT16H TBP CDK5 NUAK1 UBB TAF9 TPX2 CDK5R1 CCNA2 CCNA1 TAF1L UBC RPS27A TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TAF7 PLK3 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CDK2 MAPK14 MAPK11 MRE11 BRCA1 KAT5 TP53 EXO1 CHEK1 NBN TOPBP1 PIN1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 PRKAB2 TOP3A CSNK2A1 HUS1 CSNK2A2 PRKAB1 CSNK2B DNA2 RHNO1 BLM NOC2L WRN BRIP1 TP53INP1 PRKAA1 HIPK1 PRKAA2 RBBP8 ATRIP DYRK2 BARD1 HIPK2 RPA1 MAPKAPK5 RPA2 RAD50 RPA3 AURKB RAD17 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 TFRC HFE TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 STEAP3 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F MCOLN1 ATP6V1C2 ATP6V0A1 TF ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols CYP51A1 AHRR FDX1 FDXR FDX2 CYP8B1 ARNT CYP11B2 CYP46A1 CYP21A2 CYP39A1 ARNT2 CYP11B1 CYP11A1 NCOA1 CYP4V2 CYP1B1 NCOA2 POMC NR1H4 CYP7B1 CYP7A1 CYP27A1 RXRA CYP19A1 AHR G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 CDC6 CDC25A RBL2 RBL1 CDK1 MYC CCNA2 CCNA1 MAX TOP2A LIN54 PCNA LIN52 LIN37 HDAC1 LIN9 E2F1 DYRK1A E2F4 E2F5 TFDP1 RBBP4 CCNE2 TFDP2 CCNE1 CDK2 MYBL2 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases ELMO2 DOCK1 RASA1 UBA52 RAC1 SFPQ ARAP1 UBB UBC RPS27A CBL ELMO1 GPNMB LRRK2 PTK6 CDKN1B EREG BTC SOCS3 CCND1 HBEGF NRAS STAT3 HRAS NR3C1 EGF CDK4 CCNE1 CDK2 DOK1 CRK NRG2 NRG3 NRG4 EGFR PXN RHOA AKT1 ERBB2 NRG1 BCAR1 EPAS1 SRMS KHDRBS1 HIF1A KHDRBS2 KHDRBS3 STAP2 ARHGAP35 PELP1 PTPN1 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB ETV6 BIN2 KDR KANK1 GOLGA4 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) DERL2 RNF139 UGGT2 OS9 UGGT1 MARCHF6 EDEM3 EDEM2 AMFR SEL1L SYVN1 RNF103 UBA52 TRIM13 MAN1B1 RNF5 RNF185 EDEM1 UBB UBC RPS27A DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers DKK1 DKK2 TFG DKK4 AMER1 RAC1 MDM2 KREMEN1 KREMEN2 LRP5 LRP6 VAV1 CEBPB SEC31A DERL2 MAPK9 MAPK8 OS9 RICTOR KLC1 NTRK2 STAT1 BDNF GAB1 FRS3 STAT3 MIB2 NTF4 NTF3 PLCG1 CD86 EGF CD80 AREG BCL2L1 EEF1G JAG2 JAG1 ADAM10 VCP CD19 DLL1 MIB1 SEL1L DLL4 NEURL1B ADAM17 NEURL1 PPFIBP1 HGF PRR5 GSK3B PIK3CD PIK3CB PIK3CG CTBP2 CTBP1 MLST8 PDPK1 PIK3CA LCK BCR ERLEC1 FYN CSK TCF7L2 PTPN11 MTOR TNRC6C PTPN6 IL10RA DNMT1 MCL1 PDGFRA NCBP1 NCBP2 PSENEN PSEN2 IL22 PSEN1 APH1A NCSTN APH1B HES5 PDGFB HEYL ETV6 FIP1L1 BIN2 KDR TP53 IL10 MYH9 RBPJ ATIC TNKS TNKS2 TPR PAPSS1 TYK2 GOLGB1 RRBP1 HEY1 DCTN1 HEY2 DUSP16 RPS6 FGFR1 EGFR TGFB1 BAD CASP9 NRG1 HHAT CLTC HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 DUSP10 PSMD3 PSMD1 DUSP8 DUSP9 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 PSMC1 FOXO6 FLT3LG PSMC2 FOXO4 FOXO1 RPS6KB2 HDAC4 MRAS SHOC2 ESR1 TENT4A KIAA1549 MPRIP TRIM24 PRF1 AGTRAP FOXM1 AP3B1 SND1 ICOS ZC3HC1 ESRP1 AKAP9 GSK3A KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 LMNA AGK QKI CLCN6 FAM131B AGGF1 IRF4 ALK PTEN EML4 PPM1B HIP1 PRKAR1A BCL11A EIF2AK3 STRN BIRC6 FN1 CCNC CCNB1 SRC CBL CTNNB1 MET TGFA ZMYM2 SHC1 YWHAB NRAS RAP1A MAPK1 HRAS SNW1 MAPK3 MAP2K1 MAP2K2 FRS2 BRAF SOS1 NRG2 NPM1 NRG3 NRG4 HDAC3 CSNK1A1 MAMLD1 TRIP11 CEP43 BCL2A1 EP300 TBL1X CREBBP NCOR1 TBL1XR1 GCC2 RHOG GOLGA4 FKBP1A CALM1 JUN KRAS MAML2 MAML1 FOXO3 BCL2L11 JUNB ERBIN NOTCH1 CARS1 RBX1 PPP1CB KIT RAC2 IHH HDAC1 MARK3 SHH DHH NCOR2 KAT2B KAT2A STAT5A STAT5B PIM1 NOX4 FZD5 GRB2 FZD4 WNT3A FGFR3 SYVN1 FZD6 FZD8 CDC37 KANK1 ITGA2B SPRED3 SPRED2 SPRED1 TGFBR1 TGFBR2 NF1 TSC2 AKT1S1 SPTBN1 MSN RB1 CDKN1A CDKN1B EREG BTC EPGN HBEGF APC SQSTM1 TPM4 TPM3 FLT3 PTPN12 PPP1CC PPP2R1B PPP2R1A CDK8 FGFR2 CLIP1 KLB IRS1 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 PPP2R5E FGF22 GAB2 FGF16 FGF19 FGF18 HDAC5 PPP2R5B FGFR4 PPP2R5A HDAC2 FGF10 PPP2R5D PPP2R5C HDAC8 HDAC9 HDAC6 HDAC7 CUX1 FGFR1OP2 MYO18A CPSF6 PPP2CA PPP2CB GZMB HDAC10 HDAC11 RANBP2 TWIST1 RNF213 ATG7 PDGFRB TRAT1 NTRK3 PIK3AP1 WDR48 POLR2A SMAD2 POLR2B POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J ESR2 POLR2K POLR2L NR4A1 GTF2F1 GTF2F2 KIF5B AXIN1 CAMK2B CAMK2D CAMK2A LMO7 AKT2 MYC AKT3 AKT1 ERBB2 HES1 CAMK2G PHB1 ITGB3 ARAF MAPKAP1 PEBP1 ARRB1 PIK3R3 IQGAP1 PIK3R2 PORCN ARRB2 PIK3R1 RAP1B JAK2 PIK3R6 BRAP PIK3R5 FGB WDCP FGA LYN KSR1 VWF LRRFIP1 FGG KSR2 YES1 APBB1IP CNKSR2 CNKSR1 RAF1 ERLIN2 TLN1 MOV10 VCL ZAP70 AGO3 MAP3K11 AGO4 AGO1 RNF43 AGO2 BAG4 CD28 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP2 IGF2BP1 IGF2BP3 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors FSHB GPHB5 FSHR GNRH2 CGA GNRH1 TSHB TSHR LHCGR GNRHR2 LHB GNRHR GPHA2 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants KIT GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism PNPLA7 GDE1 GDPD1 GDPD3 GDPD5 ENPP6 PNPLA6 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription FCER2 NOTCH2 GZMB EP300 MAMLD1 RBPJ MAML2 MAML1 HES1 HES5 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events RAPGEF1 CRK YWHAB CRKL RAP1A MAPK1 MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 BRAF NGF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle ARHGAP26 RHOC ARHGEF5 ACBD5 MACO1 VAMP3 C1QBP ARHGAP39 ARHGAP21 LMAN1 STX5 TFRC MCF2 MCAM ERBIN CCDC187 VANGL1 ARHGAP32 FMNL2 DIAPH3 VAPB ABCD3 TJP2 CAV1 VAV2 RTKN RHOA ARHGEF10L STK10 AKAP13 ROCK1 SLK LBR ROCK2 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 MYO9B FLOT1 CIT DAAM1 FLOT2 ARHGEF1 PKN3 IQGAP1 ARHGEF25 PIK3R1 ARHGEF28 ARHGAP1 IQGAP3 STOM FMNL3 ARHGAP5 ARHGAP35 PREX1 STARD13 OPHN1 JUP ARHGDIA CAVIN1 BCR MCF2L ANLN TMPO DIAPH1 ABR RACGAP1 DLC1 PKN2 PKN1 DEPDC1B ARHGAP18 ARHGEF40 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation ITGA2B FN1 SRC LAMTOR2 LAMTOR3 ITGB3 ARAF PEBP1 ARRB1 WDR83 IQGAP1 ARRB2 RAP1B YWHAB MARK3 FGB IL17RD NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A GALNS AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade F11 GP1BA PROS1 F5 F8 SERPINC1 F10 GP9 GP1BB SERPIND1 GP5 VWF F2 F9 PROC SERPINE2 SERPINA5 ANO6 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase CDC20 CDC14A ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 FZR1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A8 SLC30A1 SLC30A5 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6A TNRC6B PTEN MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation MAPK1 INS MAPK3 SOS1 IRS1 IRS2 SHC1 GRB10 INSR DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i ALG2 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle NISCH KCTD13 PKP4 EPHA2 MUC13 RND2 TFRC KTN1 VANGL1 BLTP3B GOLGA3 FNBP1 NUDC SCRIB PIK3R2 PIK3R1 ARHGAP1 TXNL1 ARHGAP5 KIF14 ARHGAP35 FRS3 DSG1 WDR6 PRAG1 PLXND1 FAM83B RBMX ANKRD26 DST KIDINS220 CAV1 FRS2 ALDH3A2 TNFAIP1 PTPN13 LEMD3 VANGL2 DEPDC1B UBXN11 LRRC1 CKAP4 DLG5 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin LEP STAT5A STAT3 STAT5B IRS1 IRS2 SOCS3 JAK2 PTPN11 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions EZH2 H2AX CDH4 RAC1 IL6 MDM2 JAK1 CDH15 TRAF7 H3-3B H3C8 MTBP ZC3H12A CSNK2A3 H2AJ SRC CTNND1 CADM3 CDH1 CADM1 CADM2 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 FARP2 STAT3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 TIAM1 CDH9 MAPK3 PVR CDH7 FOXQ1 CDH6 CDH5 CDH3 H2AB1 TLE1 CTSL ZBTB33 IL6ST H2AC8 H2AC6 PKM H2AC7 CDH10 MYCN CDH12 TMEM258 CDH13 CDH17 CDH18 CDH19 MCRIP1 NECTIN4 NECTIN3 NECTIN2 OST4 NECTIN1 OSTC STT3A CDH2 ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 JUP SIRT1 TCF3 CDC42 RBBP4 RBBP7 H2AZ2 TGIF2 TNRC6C DOCK1 TNRC6A TNRC6B ARHGEF4 ANGPTL4 ARHGAP32 HEYL SOX10 ELMO1 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 VAV2 PRDM8 BHLHE22 KDM1A CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 SNAI1 ZNF217 FURIN PCSK6 ANK3 TYK2 RB1 POMT2 DNM2 POMT1 SEC11A KLF9 SEC11C FOXJ2 STRAP FOXP2 SP1 SPCS3 SPCS2 SPCS1 HDAC2 PSMD8 CANX PSMD6 IL6R BIRC2 PSMD7 PSMD2 PSMD3 XIAP PSMD1 ANG KMT5A KLF4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FOXA2 PSMD13 PSMA7 TWIST2 RELA TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 HACE1 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RNF19B ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 JAK2 H4C9 MOV10 VCL AGO3 AGO4 H2AC20 AGO1 AGO2 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAG YWHAZ YWHAE SFN CHEK2 CDC25C YWHAB WEE1 CCNB1 CHEK1 CDK1 YWHAH YWHAQ CCNA2 CCNA1 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle PTK6 CDK4 CDKN1B CCNE1 CDK2 CCND1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines TBK1 STAT6 STING1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking SERPINA1 PPP6C TFG PPP6R1 PRKAG1 PPP6R3 PRKAG2 TMED2 CTSC CD3G TRAPPC2L LMAN1L F5 F8 CD3D PRKAG3 SBF2 TRAPPC6A TBC1D20 RAC1 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TFRC TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 FTH1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 FTL SEC23IP CNIH1 KIF20A KLC1 CNIH2 KLC4 CNIH3 KLC3 FOLR1 KLC2 BET1 NEDD8 KIF11 KIF15 KIF23 EGF KIF22 AREG KIF26A TF COPS5 SCARB2 ITSN2 AGFG1 GAPVD1 BIN1 AMPH GRK3 CLTCL1 PACSIN2 PACSIN3 SNX9 PIP5K1C KIAA0319 PACSIN1 TOR1A YWHAG SYNJ2 TOR1B SNAP23 SYT9 SYT8 SNAP91 DAB2 AAK1 IL7R PICALM STON1 STON2 PIK3C2A SLC2A8 SGIP1 COL7A1 EPS15L1 PRKAA2 ARFGAP1 OCRL EPN1 EPN2 GAK CTTN ARF6 LRP2 FCHO1 FCHO2 RACGAP1 REPS2 UBQLN1 UBQLN2 HIP1R SNX18 NECAP2 NECAP1 CD4 SYT11 TRIP10 AP2A1 AP2A2 LDLRAP1 AP2M1 MAP1LC3B STXBP3 AP2S1 RAB27B LDLR CHRM2 GJA1 AP2B1 GJB2 ADRB2 MAN2A1 MYO5A ARPC1A WASL GNS MYH9 ARFGAP2 DVL2 KDELR1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 MYO1C CPD AP3S1 SH3D19 TPD52 BLOC1S4 BLOC1S6 SNX2 BLOC1S3 SFN SNX5 TBC1D8B SNAPIN SORT1 DTNBP1 PUM1 TPD52L1 GOLGB1 YIPF6 ACBD3 SYNJ1 ALS2 GJC1 GJD2 MAN1A2 MAN1C1 GJA10 MAN1A1 CLINT1 DENND1C DENND1B GDI1 DENND5B DENND1A KDELR3 GDI2 RINL TRAPPC12 DCTN1 TRAPPC11 DENND5A TRAPPC13 DENND2D DENND2C DENND2B DENND2A RAB3IL1 RAB32 RAB31 RAB38 DENND6B RIN3 NSF DENND6A RIN1 RIN2 DENND3 RAB21 ALS2CL CHML GRIA1 ANKRD27 DENND4B CCZ1B DENND4A DENND4C HPS1 RAB39A CCZ1 HPS4 RAB39B TRAPPC8 RAB12 EGFR RAB18 VPS45 RAB3GAP2 RAB3GAP1 MON1A MON1B FNBP1L FNBP1 CLTC CLTA UBA52 DCTN6 DCTN5 DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 UBB OPTN UBC RPS27A AP3B1 GALNT1 RAB27A KIFAP3 CSNK1D HIP1 KIF3B KIF3A TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 KIF3C VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 RAB3IP CHMP5 ARF4 AP1G1 ACTR1A AP1S2 AP1B1 AP1S1 AP1S3 AP1M2 AP1M1 GALNT2 SH3GL3 SH3KBP1 STAM CBL RAB8A HGS EPS15 EXOC8 TGFA STAM2 SH3GL2 EXOC7 SH3GL1 RALA YWHAB AGPAT3 SBF1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 DCTN2 DCTN3 GBF1 RAB11A TRIP11 APOB C2CD5 ITSN1 SLC2A4 RALGAPA2 TBC1D1 RALGAPB TBC1D4 ASPSCR1 RAB10 RAB14 GJB1 RAB13 USP6NL SCOC CFTR SYS1 GCC2 GCC1 RABEPK YWHAQ RAB43 GOLGA4 GOLGA1 ARFGAP3 ARFIP2 NAA30 COG8 COG7 COG6 COG5 COG4 INS COG3 CALM1 GJA3 COG2 RAB7A GJA5 COG1 YWHAE GJA4 VAMP3 APP NAA35 GJA9 NAA38 GJA8 VAMP4 GJC2 NAPA GJB4 NAPB GJB3 TMF1 GJB6 STX16 GJB5 RHOBTB3 GJB7 LMAN1 ARL1 GJD4 STX5 GOLGA2 NAPG GJD3 YKT6 STX10 TGOLN2 ARFRP1 VPS51 VPS53 VPS52 VTI1A YWHAH STX6 VPS54 RAB6A RAB6B RIC1 IGF2R RGP1 RAB9A RAB9B RABGAP1 YWHAZ GABARAP GGA2 RABGEF1 GGA1 GGA3 TBC1D13 TBC1D10C TBC1D14 TBC1D17 TBC1D10A TBC1D15 RAB8B TBC1D10B TBC1D16 GABARAPL2 RAB4A SYTL1 RAB33A RAB33B RAB11B WNT5A TBC1D2 PLIN3 RABEP1 TBC1D3 TBC1D7 RAB35 TBC1D24 TBC1D25 ULK1 RAB7B PLA2G6 CHM ARF5 ARCN1 RAB5B RAB5C RAB5A CD55 GPS1 KDELR2 MYO6 FZD4 MIA2 COPS4 COPS2 GOSR1 ANK2 ANK3 ANK1 TSC2 TSC1 SPTBN4 SPTBN5 SPTA1 COPZ2 SPTBN1 COPZ1 SPTBN2 KIF4B KIF4A RAB41 SYT2 SYT1 EREG SPTAN1 SPTB BTC VAMP2 RAB30 EPGN DNM1 HBEGF RAB36 DNM3 ARF1 CTSZ AP4E1 CLTB BET1L AP4M1 AP1G2 BLOC1S1 SEC23A CLVS2 AP4S1 CLVS1 SAR1B TXNDC5 HSPA8 M6PR AP4B1 DNM2 VAMP8 VAMP7 DNAJC6 DNASE2 SEC24B DYNC1LI1 SEC24A DYNC1LI2 ZW10 SEC24D TMED3 SEC24C TMED7 SLC18A3 TMED9 RAB3A KIF18A SEC13 COPG2 COPG1 COPB2 COPA DYNLL1 COPB1 MAN2A2 TMEM115 DYNLL2 CHMP4C COPE KIF2A CHMP4B CHMP3 CHMP4A KIF2C CUX1 CHMP6 KIF2B CHMP7 PAFAH1B1 DYNC1I2 COPS7B COPS7A COPS3 COPS6 CHMP2B DYNC1I1 CHMP2A COPS8 DYNC1H1 CENPE AGTR1 LNPEP AVPR2 AVP TJP1 STX4 GOLIM4 TACR1 CAPZB CYTH3 CYTH2 GOLGA5 CYTH4 SNAP29 CYTH1 ALPP CAPZA1 CAPZA2 GRK2 KIF5C PLA2G4A KIF5B KIF5A KIF28P KIF12 USE1 AKT2 KIF19 KIF13B AKT3 KIF1C KIF21A AKT1 KIF1B KIF21B PRKAB2 KIF1A MIA3 KIF25 KIF6 PRKAB1 KIF27 RINT1 KIF9 KIFC2 KIF16B KIFC1 KIF20B NBAS ARRB1 STX18 BNIP1 ARRB2 SURF4 KIF18B KIF26B ARF3 MCFD2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 PPP2CA FLRT1 SPRED2 PPP2CB SPRED1 PPP2R1A SOS1 TGFBR3 UBA52 GIPC1 ANOS1 FGFRL1 FLRT3 UBB FGF1 FGF2 UBC FGF3 FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF22 MKNK1 FGF18 SPRY2 PIK3R1 PIK3CA FGF10 NRAS GAB1 MAPK1 FRS3 HRAS MAPK3 PLCG1 FRS2 BRAF PTPN11 FLRT2 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAG YWHAZ EP300 PDPK1 PSMC6 YWHAE SFN YWHAB SP1 UBE2I YWHAH CAV1 YWHAQ SMAD4 SMAD3 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 VAC14 MTMR9 MTMR4 PIK3R4 PIK3C3 FIG4 PIKFYVE MTMR7 MTM1 PIK3C2A RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle ARHGAP12 ARHGAP26 RAB7A VAMP3 ARHGAP39 ARHGAP21 LMNB1 LMAN1 MCAM PLXNB1 MOSPD2 ADD3 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 STEAP3 CAPZB CAV1 ANKFY1 FILIP1 GOLGA8R LBR EFHD2 PGRMC2 PAK6 PAK5 CPNE8 WHAMM PIK3R2 PIK3R1 AKAP12 ARHGAP1 HINT2 ACTN1 SLC4A7 ARHGAP5 ARHGAP35 RHOD STBD1 PLXNA1 EMD DBN1 ARHGAP17 TMPO DIAPH1 RACGAP1 VRK2 LEMD3 DEPDC1B TOR1AIP1 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME ADH1A MAPDA NT5C2 ABCG2 SLC22A3 ABCB1 SLC22A2 SLC22A1 PCK1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK MAPK7 SOS1 MMP3 PRKCA HBEGF EGFR NRAS GAST RPS6KA3 RPS6KA2 MAPK1 HRAS RPS6KA1 MAPK3 CCKBR PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription CBFB RUNX3 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer TGFA EGF EREG BTC AREG EPGN HBEGF EGFR FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm SHH GATA4 IHH BMP4 FOXF1 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy VPS33A VPS33B VPS39 VPS18 TUFM VPS11 VPS16 VPS41 UVRAG MAP1LC3B VPS45 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling LCAT APOC2 ALB LIPG APOA1 APOE ABCG1 CETP APOC3 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 SZT2 SAMTOR SEH1L NPRL2 NPRL3 WDR59 RPTOR FLCN MIOS ITFG2 KPTN DEPDC5 WDR24 RRAGA SH3BP4 RRAGC FNIP1 RRAGB FNIP2 RRAGD KICS2 CASTOR1 CASTOR2 TCIRG1 SLC38A9 ATP6V1E1 RHEB ATP6V1E2 LAMTOR2 ATP6V0B LAMTOR1 ATP6V1G1 LAMTOR4 ATP6V0E1 LAMTOR3 ATP6V1G2 LAMTOR5 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MLST8 SEC13 SESN1 SESN2 MTOR OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions SEMA6A SEMA6D SEMA7A TYROBP ITGB1 PLXNA2 PTPRC PLXNB3 TREM2 SEMA4D SEMA3E ITGA1 SEMA4A PLXNA1 PLXND1 PLXNA4 CD72 SEMA5A PLXNC1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency ACAT1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System HLA-DRB3 SERPINA1 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 ASH2L CTSC CD3G MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 SEC22B TEAD3 H3-3B HLA-DPA1 TEAD4 H3C8 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 CD59 YAP1 GAB3 SEC31A DERL3 DERL1 RAP1GAP2 SIPA1 DERL2 TRBV12-3 H3C15 TRAPPC1 NOS3 PAK1 TRBV7-9 OS9 SPOP RICTOR HLA-DOA HLA-DOB PAK3 LAG3 PAK2 KIF20A BRD4 KLC1 SUZ12 H2BC9 KLC4 H2BC8 KLC3 H2BC5 KLC2 OSBPL1A STAT1 H2BC3 KIF11 STAT3 KIF15 CTSO MIB2 ACTR1B H2BC1 TRAV8-4 CTSH HLA-DPB1 CTSF FOSB CTSE KIF23 CD86 KIF22 TUSC3 HLA-DMA CD80 HLA-DMB TRAC RILP H2AB1 CD74 GRAP2 NEK2 KIF26A MAP3K8 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C PRKCE SEL1L TCF7 BTLA THEM4 TNFRSF14 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 MAP3K14 PRR5 GSK3B PIK3CD DPY30 STK10 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 LCK IRF1 STOM H2BC11 PRKAA1 PRKAA2 JUP LEF1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN DIAPH1 CSK RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 TNRC6A TNRC6B GPR84 ELOB ELOC ACAA1 SLC27A2 BIN2 ACTB FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 TP53 NF2 FBXL3 FBXL5 CCT2 SPHK1 TCP1 CDA ILF3 CCT8 TUBB4B NUP205 POM121 FNTA NUP188 FNTB IL1R1 AAAS POM121C NUP42 IFNAR1 NUP62 TPR CD79B NUP88 CD79A RAE1 KPNA1 IGHM NUP214 BLNK NDC1 NUP210 JAK3 NUP155 IFNGR1 NUP153 IFNGR2 NUP93 TYK2 NUP50 IGHD NUP35 NUP54 S1PR1 STAT2 PANX1 KPNA7 KPNA4 KPNA5 GSN KPNA2 KPNA3 KPNB1 COLEC12 TAX1BP1 TGFB1 EIF2AK2 CASP9 ISG15 CALR CLTC RPLP0 CLTA HSP90AA1 DNAJC3 CANX MTAP GBP1 ABCE1 HSPA1A BLK HLA-B VNN1 PDZD11 EEA1 TASL RBSN IRF5 PROS1 MRC1 CD33 HSPA5 SLC15A4 CD300A EIF4A3 THOC5 ALOX15 CD177 RAB27A IRF4 ATP8A1 CLEC10A CLEC4A CLEC4C CLEC4D SOX2 ATP11B CLEC4E ATP11A CLEC7A CLEC6A CARD9 PRKRA TARBP2 TRPM2 ATP8B4 TRPC1 ATP7A ANO6 LAMA5 FN1 VTN AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 PSME1 PSME2 APEH PSMB10 PSMB8 PSMB9 LPCAT1 UBE2D2 IGHV3-23 IGLV AGPAT2 IGLV2-8 IGKV1-16 IGKV1-17 PLD2 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DSC1 CDC34 PLA2G2A IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 PPL IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PI3 IGKV3-15 IGKV3-11 V2-8 V1-20 CEACAM1 ZEB1 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ASAH1 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 LAMP2 V1-5 V1-3 MT2A IGKV3D-20 V5-6 TRAF6 IGHE IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 CCR5 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 CSF1 VAPA RPS6KA1 TNFSF11 YWHAZ ATG12 ATG5 RAC2 S100A9 S100A8 POMC FUCA1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 VAV3 IFNA17 SIKE1 MAVS IFNA10 RIGI NME2 VAV2 RAB5B IMPDH1 RAB5C GSTA2 IMPDH2 CA1 XDH FCGR3B HSP90AB1 ROCK1 ACTG1 BST1 RBBP6 OTUD5 VIM FURIN KCNAB2 CAB39 EIF4E LAMTOR2 LAMTOR1 ITGB5 LAMTOR3 EIF4G1 RAB3D RAB44 SNAP25 VAMP2 STX1A RAB37 ANXA1 RAB4B SEC23A PTPN12 SAR1B RAB24 SEC24B SEC24A MLEC MUC12 MUC13 SEC24D MUC15 SEC24C MUCL1 MUC3A MUC5AC MUC3B HMGB1 UBE2L3 CFP CASP8 CASP5 CASP4 CASP1 MUC1 RIPK3 IL18 MUC2 TRAF2 IL1A COPB1 IL1B IRF2 MUC7 PELI1 MUC4 MUC6 MUC16 MUC17 MUC19 BIRC2 PLAUR BIRC3 MUC5B PRKN MUC20 MUC21 SDCBP RIPK1 FADD ELANE GSDMD MGST1 ITCH STUB1 GSDME CPNE1 FPR2 CPNE3 HSPA9 UBE2B F2 SNAP29 PTAFR AHCYL1 NOS1 PRKACA ADA2 HP STIM1 ORAI2 ORAI1 CAMK2B CAMK2D CAMK2A ITPR1 KNG1 ITPR2 ITPR3 CAMK2G MMP3 SURF4 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ITK FYB1 ZAP70 LCP2 TXN LAT CD101 MAP2K7 LAT2 MAP2K6 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 ARSA BTN3A2 BTNL2 IL6 CXCL8 MAPK9 MAPK8 MAPK7 IFNB1 MAPK10 TCN1 PLCG1 TNFSF13 BCL2 CD81 C4BPA BCL2L1 C4BPB CLU SERPING1 EEF1A1 CPB2 CFH C5AR2 C5AR1 CFI EEF2 C6 C7 ADAM10 C9 CD19 C8B C8A C8G ADAM17 CR2 CD46 CPN2 CPN1 CFHR2 NAPRT CFHR1 CFHR4 CFHR3 CFHR5 PDXK ALOX5 PTGS2 C3 C4A CD22 C5 C4B_2 CFB IL7R C2 SERPINB6 PLAU MGAM TXK CHIT1 EIF2S3 EIF2S2 EIF2S1 BECN1 CENPX MMP25 CEACAM6 CEACAM8 PRKCSH NOS2 ADAM8 CISH CSH1 PRLR GHR GOLGA7 GH2 SOCS2 MMP8 GH1 GBP6 CXADR LRRC7 IL10 OLR1 MYH9 TIFA CEACAM3 ALPK1 CD58 SIRPA JAML PCBP2 CD99 BST2 SELL CALM3 TREM1 CALM2 ARIH1 TXNIP HNRNPA2B1 IL17F IL17A PPIE GATA3 DDX3X SFN SIRPB1 DYNLT1 CD226 CD1D MMP9 CD1C CD1B cd21 CD1A KLRK1 SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 COL1A2 KIR2DS2 ATG14 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 HNRNPF SIGLEC9 NCR1 NCR2 CD200R1 NCR3 HCST LILRA6 LILRA1 LILRA2 LILRA3 CASP10 LILRA4 LILRA5 NCR3LG1 LAIR2 HSPA1B MICA LAIR1 MICB NPDC1 CLEC5A GLYCAM1 LILRB1 KIR3DL1 LILRB2 KIR3DL2 LILRB3 LILRB4 LILRB5 CD40LG EIF4G3 SIGLEC1 EIF4G2 SIGLEC8 EIF4E3 SIGLEC7 SIGLEC6 SIGLEC5 CD96 SNRPA1 OSCAR CEBPD CD8A KLRF1 CD300E CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM HLA-H HLA-C KLRD1 HLA-F ULBP1 ULBP3 PIANP HLA-G HLA-E KLRG1 CLEC2B FCGR2B CLEC2D TOMM70 IL17RC IL17RA TLR1 TLR6 PAG1 TLR2 PDIA3 UBE2D3 OAS2 RORC LTF GBP2 GBP4 FOXO1 SOCS3 SP100 PTPN18 IL37 PTPN20 NDUFC2 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 S100A1 CD36 FBXO32 IRAK3 TIRAP PIN1 PTEN ITGAL SRP14 TRIM63 APAF1 ITGA4 TNFRSF18 PRDX6 GSTP1 PTPN1 IL2RA CCL2 SLCO4C1 ATOX1 SOD1 PTPN4 LGALS3 SLC11A1 SMARCA4 PVR CTSV CTSL IL6ST CTSK PKM NECTIN2 NPM1 IFITM3 VEGFA IFITM1 IFITM2 FCER1A IFIT5 MS4A2 IFI35 IFIT1 IFI30 IFIT3 IFIT2 ICAM1 TRIM29 TRIM26 TRIM22 FAAP100 GBP5 GBP7 RSAD2 IFI27 TRIM17 PDE12 TRIM14 NLRP1 ATF6 TRIM10 EGR1 IRAK1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 RNASEL IFI6 FAAP24 FAAP20 IL2 PGGT1B IL3 FLNB HSPA1L IFI44L ILF2 MID1 IP6K2 VCAM1 FANCM FANCL FANCA HSPA2 FANCB FANCE FANCG FANCF CAT ISG20 XAF1 RETN FCGR1BP CIITA ADAR OASL TRIM68 TRIM62 OAS1 KRAS OAS3 IRF8 IRF6 EIF4E2 IRF9 SAMHD1 TRIM46 TRIM48 GBP3 SNCA TRIM45 HGSNAT MX2 JUNB MX1 TRIM35 RNF111 TRIM38 TRIM31 TRIM34 IST1 NEDD4L DHX58 TBC1D10C RNF125 RNF216 FRMPD3 GMFG ABCA13 PGLYRP1 NHLRC3 MCEMP1 RNASE3 CDK13 SCAMP1 RNASE2 UNC13D FLG2 GPI PADI2 CRACR2A PRDX4 S100A11 AZU1 PLA2G6 PA2G4 HRNR PIGR SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 PLEKHO2 SERPINB10 GRN SERPINB12 AGA ERP44 LRG1 YPEL5 GHDC TMEM179B EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A S100A7 BRI3 PTPRB NIT2 FCAR GM2A ACP3 RNASET2 TMBIM1 CANT1 FGL2 PRCP CPPED1 MNDA FOLR3 VPS35L CALML5 C6orf120 KRT1 SLPI CRISPLD2 TMEM63A WWP1 MMTAG2 SYNGR1 VAT1 PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 CYSTM1 PTPRJ GLIPR1 CAMP CD53 RAP2C FPR1 RAP2B CSF2 DNASE1L1 CSTB PGRMC1 CREG1 ORMDL3 GCA PTGES2 SVIP QPCT CD68 MPO COTL1 ENPP4 OSTF1 CD93 CCL11 IRAG2 ATAD3B DOK3 ADGRG3 DPP7 CCL19 ALDH3B1 GGH DNAJC13 TARM1 DEGS1 MS4A3 TNFAIP6 CCL22 CRISP3 HEBP2 CHI3L1 CCL20 CLEC12A MVP TMEM30A CMTM6 FKBP5 PDAP1 S100P PTX3 GLA CSF1R PSAP CXCL10 ABL1 CCL5 CCL4 CCL3 FANCC BCL6 CCR1 PPBP CCR6 CCR2 CR1 OPRD1 CXCR1 RNF34 CXCR2 NLRC4 CCL3L3 PML CXCL1 CXCL2 TWIST1 TAP2 TAP1 CD207 SEC61A2 MRC2 SEC61A1 SEC61G LIFR PTPN22 SEC61B KCTD6 TAPBP STX4 CAPZB SMAD3 SMURF2 CAPZA1 CAPZA2 SMURF1 TIMP2 TIMP1 SMAD7 SLC2A3 YBX1 CASP2 OPRM1 IFNG IQGAP1 RAP1B JAK2 FGB FGA PGLYRP4 PGLYRP3 FGG PGLYRP2 SLA2 SLA TNFRSF8 TNFRSF4 RAF1 REG3A REG3G VCL TNFRSF17 TNFRSF9 LTA4H KIR3DS1 LEAP2 TNFSF13B TNFRSF25 TNFRSF6B TNFSF18 TNFSF14 TNFSF15 TNFSF12 DAPP1 GNLY EDARADD EDAR LPO HSPA6 DCD LTA LTB F12 KLKB1 RNASE6 RNASE8 RNASE7 TNFRSF11B TNFRSF11A ERAP2 ERAP1 BPIFA1 BPIFA2 BPIFB1 TCIRG1 BPIFB4 BPIFB6 CD27 FTH1 TNFRSF13B ATP6V1E1 TNFRSF13C ATP6V1E2 EDA2R TNFRSF12A ATP6V0B ATP6V1G1 CD70 ATP6V0E1 EPPIN ATP6V1G2 EDA CHGA KIR2DS4 KIR2DS5 TNFSF6 ATP6V1B2 TNFSF4 ATP6V0D1 TNFSF9 TNFSF8 ATP6V0C ATP6V0D2 S100A7A FTL ITLN1 SIGLEC16 ATP6V1B1 SIGLEC15 ATP6V1A KLRC2 HTN1 HTN3 CAND1 LTBR ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 LCN2 ZBP1 TBK1 IRF3 NLRP4 DTX4 FCER1G AP2A1 CSF3 AP2A2 IL1RN TNF PRKACG IL12B IL12A IL10RB PRKACB IL1R2 IL10RA AP2M1 LIF MYLIP TNFRSF1B TNFRSF1A FCER2 NPC2 STXBP2 A1BG AP2S1 A2M HRG SERPINA3 ORM1 ORM2 AP2B1 QSOX1 AHSG P4HB IDH1 RAPGEF3 RAPGEF4 CD63 F13A1 CFL1 TALDO1 GNS PECAM1 AAMP DERA SDC1 PYGB PYGL MANBA GAA PGAM1 ALDOC ALDOA CD44 DBNL AGL GYG1 DCTN1 TKFC MAN2B1 HPSE B4GALT1 HK3 PGM2 PGM1 DEFB103B DEFB105B DEFB129 DEFB128 DEFB131A DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B DEFB108C DEFB130A DEFB130B DEFB4B GALNS PFKL LIMK1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE OPTN FLT3LG TNFAIP3 AMPD3 APRT CYLD PNP MAOA PPM1B EIF2AK3 PLPP5 PLPP4 PLD3 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CYB5R3 P2RX1 IL4 IL18RAP IL13 RAG2 RAG1 TSLP IL7 BRWD1 CRLF2 PLAC8 RHOA ICAM2 ICAM3 RELB RPS6KA5 CD209 ITGB1 CYFIP1 RAB10 RAB14 STBD1 RHOG ELMO2 DOCK2 DOCK1 NANOG RAB7A VAMP3 PLD1 IL34 IQGAP2 IL16 IFNLR1 IFNL1 TXLNA PTPRZ1 PRTN3 STX3 AOC1 DGAT1 FABP5 ITGAM ITGB2 ICAM4 ICAM5 ITGAX ITGB7 CD47 ITGAV ANXA2 PTK2 VASP CAP1 ENAH MYO9B CUL2 ABL2 NCK1 EVL SOS2 MMP2 NEU1 CTSA ELK1 SQSTM1 ARF1 CTSZ COMMD9 COMMD3 TXNDC5 HSPA8 DNM2 VAMP8 VAMP7 SOCS6 SOCS5 GSTO1 IRS1 PIK3R4 IRS2 FGF2 GAB2 TLR9 PIK3C3 IL9 IL9R CSF3R IL6R LRR1 CCNF KEAP1 CBLB UBE2L6 HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 TRIM21 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 ARMC8 UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 SIAH2 SIAH1 LNPEP MEX3C TRAT1 UBAC1 PIK3AP1 FBXL8 FBXL4 DZIP3 SH2B3 FBXL7 RNF220 DET1 TEC LRSAM1 SH3RF1 TRIM9 TRIM4 ARIH2 LRRC41 RNF144B GAN RNF138 RNF130 HUWE1 KLHL2 CST3 TTR UBE2G1 KLHL3 H2AZ1 UBE2G2 KLHL9 LYZ SPSB2 SPSB1 KBTBD6 KLHL5 TSPAN14 NEDD4 RLIM SEMG1 TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D ART1 FBXO27 DEFA1B LTN1 PRSS3 PRSS2 RNF19B UBE3A DEFA6 UBE3B DEFA4 FBXO21 DEFA5 UBE2Z DEFA3 FBXO22 NPEPPS RNF19A FBXW12 KIF5C ANPEP AREL1 FBXW8 KIF5B UBE2E3 KIF5A FBXO17 UBE4A FBXO15 MME UBE2E2 ATP6AP2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 CD180 FBXO44 LY86 FBXO41 LBP FBXO40 BPI SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 RNF182 UBA3 UBE2O TPP2 BLMH UBA1 UBE2K UBE2M TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 VHL TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 ASB3 ASB1 CHRNB4 HGF NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 IL1RAPL1 CYBB CYBA RACGAP1 NCKAP1L WASF1 WASF2 CKAP4 IL32 BAIAP2 CNTFR CNTF IL20RA ABI2 IL20RB IL22RA2 ABI1 IL31RA IL22RA1 TOLLIP C1QBP HAVCR2 CTF1 CLCF1 IL13RA2 IL13RA1 FSCN1 NDN MCL1 IL21R IL36A IL36B LGALS9 IL15RA SLC2A5 IL36G IL1F10 IL21 IL22 PSEN1 IL20 IL25 NCSTN IL26 IL24 IL11 IL15 IL19 HCK CD8B IL17RE OSMR ELMO1 IL17RB RHOU IL33 MAP3K3 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IFNL2 IL1RL2 PTK2B IFNL3 CYFIP2 WIPF1 WIPF2 WIPF3 C3AR1 ARHGAP9 BTK MEFV PLCG2 MYO5A ARPC1B ARPC1A WASL CTSG SYK WAS PYCARD IGHG3 IGHG4 IGHG1 IGHG2 NCKIPSD NLRP3 ARPC4 ARPC5 FAF2 ARPC2 ARPC3 PSTPIP1 FCGR3A ACTR3 RHOF ACTR2 FGR MYH2 FCGR1A WASF3 MYO10 P2RX7 FCGR2A MYO1C SUGT1 ARHGAP45 FRK IL2RG INPPL1 PLD4 INPP5D MOSPD2 HVCN1 GDI2 RAB31 RAB18 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ALAD PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 BCL10 RIPK2 DCTN5 PSMA7 MYD88 DCTN4 RELA MALT1 CAPZA3 PSMB6 ACTR10 PSMB7 PSMB4 PAFAH1B2 PSMB5 ATF1 UBB ECSIT PSMB2 PSMB3 NKIRAS1 UBC NKIRAS2 IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 IRAK4 SEM1 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 TLR10 PSMC3 RAP1GAP TLR5 PSMC4 LRRC14 PSMC1 PSMC2 USP14 NLRX1 PTPRC REL PELI3 NFKBIE PELI2 NFKBIB NLRC5 TREM2 NOD1 NOD2 AGER USP18 IRAK2 UBE2I S100A12 N4BP1 MAP3K1 RORA S100B TNIP2 SAA1 PIAS1 SUMO1 TYROBP MRE11 KIFAP3 KIF3B KIF3A KIF3C ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ACTR1A ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CEP290 SH3KBP1 SRC CBL CDH1 CTNNB1 SH3GL2 RALA TUBB SHC1 YWHAB CRKL NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 DCTN2 SOS1 CRK DCTN3 ARG1 ATF2 LY96 HBB CRCP HMOX1 EP300 APOB POLR3GL POLR3A POLR3B POLR3C CREBBP POLR3D POLR1C MEF2C POLR3E POLR3F POLR1D POLR3G POLR3H POLR3K TLR4 NFE2L2 PPP3CA PPP3CB PPIA RASGRP1 RASGRP3 PPP3R1 NFATC3 NFATC2 NFATC1 FKBP1A CALM1 APP JUN FASLG SOD2 FOXO3 LMNB1 BCL2L11 CAPN1 RAB6A IGF2R SLC44A2 RAB9B RBX1 ADGRE5 ADGRE3 DUS2 FLNA CD55 STAT5A STAT5B PIM1 GRB2 POU2F1 CTSD CUL3 KBTBD7 HEXB SPTBN2 MSN KIF4B GLB1 KIF4A GUSB ARSB CDKN1A SPTAN1 CDKN1B FZR1 DNM1 DNM3 CCND1 SKP2 NCAM1 NFASC CDK4 FLT3 NUP107 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 NUP160 DSN1 NUP85 RAB3A KIF18A PPP2R5E SEC13 NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DNAJC5 DYNLL1 DYNLL2 KIF2A BIRC5 KIF2C KIF2B DYNC1I2 PPP2CA PPP2CB NUP43 DYNC1I1 RANBP2 DYNC1H1 CENPE CENPS NUP37 PRL EIF4A2 EIF4A1 DSP CASP3 DSG1 ACLY PKP1 POLR2E POLR2F POLR2H POLR2K POLR2L PRKCD H2AC19 H2AC14 H2BC12L UNC93B1 AKT2 TLR8 TLR7 MYC AKT3 FUCA2 TLR3 TRBC1 BPIFB2 CTSS AKT1 LGMN ICOSLG CTSB PRKAB2 HSP90B1 FCN1 CSNK2A1 FCN2 CSNK2A2 PRKAB1 FCN3 CSNK2B MASP1 TRIB3 CFD ATF3 MBL2 CRP RPN2 EPAS1 C1QB C1QA MAPKAP1 COLEC11 RPN1 COLEC10 PIK3R3 C1S PIK3R2 C1R PIK3R1 GZMM HIF1A C1QC PIK3R6 PIK3R5 GRB10 TRAV29DV5 HLA-DQA2 CGAS LYN DDX41 WWTR1 LRRFIP1 HLA-DRB5 AIM2 YES1 IRF7 TRIM56 H4C9 HLA-DRB4 PRKDC DHX9 JUND NLRC3 ERLIN1 ERLIN2 IFI16 MOV10 DHX36 AGO3 STAT6 AGO4 XRCC6 XRCC5 H2AC20 AGO1 TREX1 AGO2 STING1 CD28 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription POLR2K POLR2L SNAPC5 SNAPC1 SNAPC2 TBP SNAPC3 SNAPC4 ZNF143 BRF2 GTF3C1 SSB GTF3C2 NFIX GTF3C3 NFIA CRCP NFIB GTF3C4 NFIC GTF3C5 GTF3C6 BRF1 POLR3GL GTF3A POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POU2F1 POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells PRKCB CBFB RUNX1 LGALS3 CREBBP CSF2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system HLA-DRB3 TNFRSF6B HLA-DRB1 TNFSF18 TNFSF14 TNFSF15 TNFSF12 UBE2M EDARADD EDAR LTA LTB IL6 JAK1 TNFRSF11B TNFRSF11A CXCL8 HLA-DPA1 H3C8 FOS VAV1 CD27 TNFRSF13B HLA-DQB2 TNFRSF13C RNF7 HLA-DQB1 EDA2R TNFRSF12A GAB3 CD70 EDA MAPK9 H3C15 MAPK8 MAPK7 TNFSF6 TNFSF4 TNFSF9 TNFSF8 PAK2 IFNB1 MAPK10 STAT1 LTBR STAT3 HLA-DPB1 PLCG1 TNFSF13 CD86 BCL2 CD80 BCL2L1 GRAP2 MAP3K8 LCN2 TBK1 IRF3 ADAM17 TNFRSF14 NFKB2 HLA-DRA MAP3K14 HGF PIK3CD PIK3CB ALOX5 PTGS2 IL1RAPL1 IL7R PIK3CA LCK IRF1 CDC42 FYN CSK PTPN11 IL32 CD4 PTPN6 CNTFR CNTF EIF2S3 IL20RA IL20RB CSF3 IL22RA2 IL1RN EIF2S2 IL31RA TNF EIF2S1 IL22RA1 IL12B TOLLIP IL12A HAVCR2 IL10RB ELOB CTF1 IL1R2 IL10RA CLCF1 BECN1 ELOC IL13RA2 LIF IL13RA1 TNFRSF1B FSCN1 TNFRSF1A FCER2 NDN MCL1 IL21R IL36A IL36B LGALS9 CENPX IL15RA IL36G IL1F10 IL21 IL22 IL20 IL25 IL26 STXBP2 IL24 IL11 IL15 IL19 HCK IL17RE OSMR IL17RB RHOU IL33 MAP3K3 IL31 OSM BATF IL17C IL4R IL11RA IL36RN MMP1 IL1RL1 IFNL2 ACTB IL1RL2 PTK2B P4HB IFNL3 NOS2 CISH CSH1 PRLR GHR PLCG2 GH2 F13A1 SOCS2 GH1 GBP6 CFL1 CTSG SYK TP53 TALDO1 IGHG4 IGHG1 IL10 SPHK1 TIFA TCP1 ALPK1 SDC1 BST2 ILF3 FCGR1A ARIH1 NUP205 HNRNPA2B1 POM121 IL17F FNTA IL17A NUP188 FNTB AAAS IL1R1 POM121C NUP42 IFNAR1 NUP62 GATA3 TPR CD44 NUP88 RAE1 KPNA1 NUP214 SFN NDC1 BLNK NUP210 IL2RG JAK3 INPPL1 NUP155 IFNGR1 IFNGR2 NUP153 MMP9 NUP93 INPP5D TYK2 NUP50 NUP35 NUP54 S1PR1 STAT2 COL1A2 HNRNPF HSPA1B KPNA7 KPNA4 KPNA5 EIF4G3 CD40LG KPNA2 EIF4G2 KPNA3 EIF4E3 SNRPA1 CEBPD KPNB1 HLA-H HLA-C HLA-F HLA-G TGFB1 HLA-E EIF2AK2 ISG15 IL17RC IL17RA RPLP0 HSP90AA1 UBE2D3 DNAJC3 PSMD8 RORC OAS2 IKBKB CANX PSMD6 GBP2 PSMD7 GBP4 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 MTAP PSMA6 PSMA3 GBP1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 ABCE1 HSPA1A PSMD14 PSMD13 CUL1 RIPK2 HLA-B PSMA7 MYD88 RELA PSMB6 PSMB7 PSMB4 PSMB5 TRAF3 ATF1 UBB PSMB2 PSMB3 NKIRAS1 NKIRAS2 UBC IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 SEM1 IRAK4 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 IRF5 LRRC14 PSMC1 FLT3LG PSMC2 USP14 NLRX1 FOXO1 PELI3 PELI2 NFKBIB SOCS3 NLRC5 NOD1 HSPA5 NOD2 AGER EIF4A3 USP18 SP100 IRAK2 S100A12 UBE2I N4BP1 RORA S100B TNIP2 THOC5 SAA1 ALOX15 PTPN18 IL37 PIAS1 PTPN20 PTPN23 PTPN13 PTPN14 IL18BP SIGIRR SUMO1 PTPN9 PTPN7 PTPN5 IL18R1 PTPN2 CD36 IRAK3 IRF4 PIN1 MAOA PPM1B SOX2 EIF2AK3 TNFRSF18 PRKRA TARBP2 IL23R PITPNA IL27 IL27RA SERPINB2 AIP MIF LCP1 EBI3 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 PDCD4 CRLF1 IL5RA CSF2RB CSF2RA PTPN1 IL5 IL2RB IL3RA CCL2 IL2RA LAMA5 SOD1 PTPN4 FN1 UBE2E1 UBE2D1 HLA-A B2M CDK1 SRC CBL PSME2 PSMB8 RALA SHC1 UBE2D2 CRKL NRAS MAPK1 HRAS SMARCA4 MAPK3 MAP2K1 IL4 IL18RAP MAPK14 IL13 IL6ST MAPK11 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 RAG2 CRK RAG1 UBE2V1 TSLP IL7 BRWD1 CRLF2 NPM1 IFITM3 ATF2 IFITM1 VEGFA IFITM2 IFIT5 IFI35 IFIT1 IFI30 IFIT3 IFIT2 ICAM1 TRIM29 ZEB1 TRIM26 TRIM22 FAAP100 GBP5 GBP7 RSAD2 IFI27 RELB RPS6KA5 TRIM17 HMOX1 PDE12 UBE2N TRIM14 TAB3 ATF6 TAB2 TRIM10 TAB1 ITGB1 EGR1 IRAK1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 RNASEL MEF2C IFI6 FAAP24 FAAP20 IL2 PGGT1B IL3 FLNB HSPA1L IFI44L ILF2 MID1 IP6K2 MT2A VCAM1 FANCM FANCL TRAF6 FANCA IGHE HSPA2 FANCB FANCE PPIA FANCG FANCF ISG20 XAF1 FCGR1BP CIITA ADAR CCR5 OASL NANOG TRIM68 TRIM62 APP OAS1 JUN OAS3 KRAS FASLG IRF8 IRF6 SOD2 EIF4E2 FOXO3 IL34 IRF9 IL16 SAMHD1 CSF1 TRIM46 IFNLR1 TRIM48 LMNB1 IFNL1 TXLNA GBP3 PTPRZ1 SNCA BCL2L11 TRIM45 PRTN3 JUNB STX3 MX2 RPS6KA1 MX1 TRIM35 TNFSF11 TRIM38 TRIM31 TRIM34 RBX1 YWHAZ POMC ITGAM ITGB2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 ITGAX TRIM25 IFNA21 DUS2 IFNA14 IFNA16 IFNA17 ANXA2 MAVS IFNA10 RIGI FLNA GSTA2 CA1 STAT5A STAT5B ACTG1 PIM1 ABL2 GRB2 NCK1 POU2F1 SOS2 VIM PTPRJ FPR1 CSF2 MMP2 FURIN CCL11 CCL19 EIF4E CCL22 MSN CCL20 EIF4G1 FKBP5 SNAP25 CSF1R ELK1 CDKN1A CDKN1B CXCL10 VAMP2 STX1A CCND1 ANXA1 SQSTM1 CCL5 ARF1 CCL4 CCL3 NCAM1 FLT3 PTPN12 NUP107 HSPA8 FANCC PPP2R1B VAMP7 PPP2R1A SOCS6 SOCS5 BCL6 GSTO1 CCR1 NUP160 IRS1 NUP85 IRS2 FGF2 CCR2 HMGB1 CASP8 GAB2 OPRD1 SEC13 CASP1 NUP133 MUC1 PPP2R5A IL18 IL9 PPP2R5D TRAF2 IL9R IL1A IL1B IRF2 PELI1 BIRC5 CSF3R BIRC2 IL6R CCL3L3 BIRC3 PML GSDMD UBE2L6 PPP2CA HERC5 PPP2CB NUP43 CXCL1 CXCL2 RANBP2 TRIM21 TWIST1 CENPS NUP37 PRL SH2B3 HSPA9 TEC EIF4A2 EIF4A1 LIFR CASP3 STX4 PTAFR NEDD4 SMAD3 CAPZA1 TIMP1 SMAD7 PRKACA PRKCD YBX1 OPRM1 CAMK2B CAMK2D CAMK2A IFNG AKT2 MYC AKT3 AKT1 HSP90B1 CAMK2G CUL5 UBA7 MMP3 PIK3R3 LBP PIK3R2 PIK3R1 HIF1A RAP1B SOCS1 JAK2 GRB10 HLA-DQA2 LYN RPS6KA3 RPS6KA2 HLA-DRB5 MAP2K3 YES1 IRF7 SLA2 MAP2K4 HLA-DRB4 SLA TNFRSF8 DHX9 TNFRSF4 RAF1 STAT6 TNFRSF17 TNFRSF9 MAP2K7 MAP2K6 TNFSF13B TNFRSF25 UBA3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling HRAS TGFA SOS1 EGF EREG BTC AREG EPGN SHC1 HBEGF EGFR NRAS PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 TPTE2 RUFY1 INPP4A INPP4B PI4K2A VAC14 MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 GDPD3 TPTE GDPD5 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 AGPAT5 FIG4 PLA2G1B LPCAT1 PIKFYVE PLA2G5 PI4KB PNPLA6 PLD6 AGPAT1 PI4K2B AGPAT2 MTMR2 LCLAT1 SACM1L AGPAT3 PI4KA AGPAT4 SBF1 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 PLA2G4B PLA2G2A DDHD2 DDHD1 GNPAT LPCAT4 PLA2G10 GPD1 GPD1L PLA2R1 PIK3CD PIK3CB PIK3CG PIP5K1C SYNJ2 INPP5E PIK3CA PIK3C2A OCRL RAB14 ALPI PITPNB TAFAZZIN AWAT2 PLD1 PIP4K2A PIP4K2B SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPAT2 DGAT2 DGAT1 RAB4A GPD2 LPIN1 STARD7 LPIN2 MGLL LPIN3 PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PIP4P1 PNPLA8 PLA2G4C MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 RAB5A INPPL1 PLD4 INPP5D INPP5J SYNJ1 ARF1 HADHB HADHA ABHD3 PCTP CEPT1 MFSD2A PCYT1B CHKB PCYT1A CHKA STARD10 PHOSPHO1 PEMT CHPT1 GPAM ACHE PIK3R4 BCHE CHAT PIK3C3 PNPLA2 LPGAT1 CPNE7 CPNE6 CPNE1 CPNE3 PCYT2 PISD PLA2G15 PGP PLA1A ABHD4 PGS1 PTPMT1 OSBPL8 OSBPL5 DGAT2L6 CRLS1 CDS2 OSBPL10 PLAAT1 PLAAT2 GPCPD1 PLAAT5 PLAAT4 PTDSS2 SELENOI PTDSS1 MBOAT1 ETNPPL ETNK2 ETNK1 PNPLA3 MBOAT7 PTPN13 CDS1 PITPNM1 PITPNM3 PITPNM2 AGK CDIPT PLA2G4A PTEN MTMR4 CSNK2A1 CSNK2A2 PLD3 CSNK2B PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 ARF3 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins MGAT2 MOGS B4GALT1 ALG14 MAN1B1 ALG13 DPAGT1 ALG8 NEU1 ALG9 ALG6 ALG2 ALG3 CTSA ALG12 ALG1 ALG11 MPDU1 RFT1 GLB1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane ARL2BP SLC25A5 SLC25A4 SLC29A3 SLC25A6 SLC28A2 SLC29A1 SLC29A2 SLC28A3 ARL2 SLC29A4 SLC28A1 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth COL9A2 COL6A5 SPTBN4 SPTBN5 NCAN SPTA1 ST8SIA4 SPTBN1 SPTBN2 ST8SIA2 AGRN CNTN2 CACNA1H CACNA1G CACNA1I SPTAN1 PTPRA SPTB NRAS MAPK1 HRAS NCAM1 MAPK3 ARTN GFRA2 CACNA1D GFRA4 NRTN SOS1 CACNA1S PRNP PTK2 PSPN CACNA1C GFRA1 RPS6KA5 GDNF CACNB1 CACNB2 CACNB3 CACNB4 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 FYN COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle CDC42EP1 GIT2 WWP2 ARHGAP26 TRIP10 RAB7A OBSCN VAMP3 ARHGEF7 ARHGAP33 ARHGAP21 SRGAP2 PAK4 TFRC GFOD1 SLC1A5 MPP7 VANGL1 ARHGAP32 DIAPH3 LAMTOR1 PAK1 PAK2 STEAP3 GJA1 CAV1 CDC42EP4 CDC42EP3 CDC42EP2 WASL GOPC ARHGEF9 ARL13B CPNE8 SNAP23 FNBP1 SCRIB SYDE1 IQGAP1 CDC42BPB ITSN1 CDC42BPA ARHGAP1 GIT1 IQGAP3 SLC4A7 STOM ARHGAP5 ARHGAP35 PREX1 OPHN1 JUP CDC42 CFTR ARHGAP17 PLEKHG3 DLC1 DEPDC1B THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP2B CHMP2A PIK3C3 BECN1 UVRAG MAP1LC3B CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PIK3R4 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CASP3 CASP7 CYCS XIAP CASP9 DIABLO APAF1 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins POM121C NUP42 PHC2 NUP62 NUP43 TPR PHC1 CBX4 NUP88 CBX2 HERC2 RAE1 CETN2 NUP214 RANBP2 PHC3 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 BMI1 RING1 SMC5 SMC6 NUP37 NSMCE3 RNF2 NSMCE2 NSMCE1 EID3 CDKN2A PIAS4 NSMCE4A SP100 UBE2I PIAS1 NUP107 SUMO1 SMC3 SUMO3 SUMO2 RNF168 BRCA1 RAD52 NUP160 NUP85 RAD21 XRCC4 STAG1 STAG2 MDC1 TDG BLM SEC13 NUP133 WRN PCGF2 SMC1A PARP1 HDAC7 RPA1 NUP205 POM121 NUP188 XPC AAAS CBX8 PML SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells NANOS3 TET2 CBFA2T2 PDPN NANOG PRDM1 POU5F1 TFAP2C EOMES CXCR4 SOX17 BMP4 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor INS TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B IDE ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 FLT3LG ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 NRAS GAB1 ATP6V0A2 MAPK1 HRAS ATP6V1H ATP6V0A4 ATP6V0E2 MAPK3 ATP6V1G3 ATP6V1D ATP6V1C1 FRS2 ATP6V1F FLT3 ATP6V1C2 ATP6V0A1 SOS1 THEM4 PTPRF KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 TRIB3 FGF23 PDPK1 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 PIK3R2 PIK3CA PIK3R1 FGFR4 FGF10 GRB10 INSR CTSD PTPN1 PTPN11 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants FLT3 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids MTMR10 CYP2C19 CYP3A4 TNFAIP8 MTMR12 MTMR14 GDE1 PRKAG2 PIK3C2G CYP2C9 PIK3C2B CSNK1G2 TNFAIP8L1 STS TNFAIP8L3 CYP2C8 TNFAIP8L2 ENPP6 ARSA SBF2 CYP2D6 TPTE2 RUFY1 CYP1A2 INPP4A CYP1A1 INPP4B PI4K2A SUMF2 AHRR CYP2E1 SUMF1 VAC14 MTMR1 HPGDS MTMR3 MTMR8 GDPD1 MTMR9 GSTM4 GDPD3 CYP24A1 TPTE GDPD5 MTMR6 MTMR7 ARSL MTM1 INPP5F ARSJ INPP5K PIP5K1A ARSK PIP5K1B ARSH PLEKHA1 ARSI PNPLA7 PLEKHA2 ARSF PLEKHA5 PLEKHA6 ARSG PLEKHA3 PLEKHA4 BMX ARSD PLEKHA8 FIG4 ABCG2 PIKFYVE PI4KB PNPLA6 OSBPL1A ACOT9 ACOT7 ACOT1 FAR1 FAR2 MCAT PRXL2B ACOT7L PTGR2 PTGS1 G0S2 THEM5 CYP19A1 FHL2 FADS2 FAAH2 FADS1 TNFRSF21 HSD17B13 AWAT1 SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 CPT1B PTGES ALOX15B THEM4 HILPDA ANKRD1 CBR1 FITM1 FITM2 GRHL1 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 ACSF2 DBI PIK3CD CPT2 PON3 PIK3CB PON2 PIK3CG PON1 PIP5K1C ALOX5 PTGS2 SYNJ2 PIK3CA PIK3C2A CYP2R1 PRKAA2 OCRL LRP2 GPX4 ALOX12B ALOXE3 ALPI TIAM2 PRKACG LDLRAP1 PRKACB CUBN APOA2 APOA5 ACOT8 EHHADH HSD17B4 ANGPTL4 ACAA1 PECR DECR2 ABCD1 SLC27A2 ACOT4 CROT SCP2 NUDT19 PHYH IDI2 MSMO1 HSD17B7 ACAT2 NSDHL BAAT STARD5 ARV1 ABCA1 SLC10A1 EBP ACOX2 DHCR24 SLC10A2 NR1H3 SLC51A PLPP6 AGPS SLC51B ACOT2 SLC27A5 LTC4S ACOX3 GBA1 HACL1 ALB HAO2 EPHX2 NUDT7 AMACR STARD7 CRAT ST3GAL2 ST3GAL3 MED19 MED18 MED11 MED29 MED28 MED22 MED21 SPHK1 GGT1 DPEP2 DPEP1 AKR1B1 GGT5 MED13L ACBD5 PPARGC1B INPPL1 PLD4 INPP5D INPP5J SYNJ1 MED9 CDK19 ECI1 ACADM DECR1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 UGT1A9 FUT2 FUT1 PTGDS MED27 MED26 MED23 MED25 B3GALT4 MED24 MED20 ABHD3 PCTP CEPT1 ABCB4 MFSD2A PCYT1B CHKB PPARD SLCO1B1 SLCO1B3 PCYT1A CHKA STARD10 PHOSPHO1 PEMT CHPT1 CYB5B KPNB1 SMPD3 ABCB11 ACSL1 SMPD2 PEX11A CIDEC B4GALT6 ELOVL5 B4GALT5 ST6GALNAC6 THRSP PNPLA2 HSD3B7 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP7A1 CYP27A1 ALOX12 ALAS1 SULT2A1 RAN FASN RGL1 MED30 ELOVL3 PIAS4 CIDEA MED31 UBE2I VDR NR1H2 RORA ABCC1 ALOX15 CYP4F3 CPT1A CYP4A22 CYP4B1 CYP4F22 CYP4F11 PTPN13 CYP4F8 PTGR1 RXRA SCD5 SMPD1 ALOX5AP SUMO2 PPARG PPARA CDS1 CD36 PITPNM1 PITPNM3 AGK PITPNM2 CDIPT AKR1C3 ACOXL PTEN MECR PLD3 ARNT CYP46A1 CYP39A1 CYP27B1 CYP11B1 ME1 ABCC3 GPX1 SLC27A1 CCNC B3GNT5 AGPAT5 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 PI4K2B AGPAT2 MTMR2 LCLAT1 SACM1L AGPAT3 PI4KA AGPAT4 SBF1 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 SREBF1 PLA2G4B PLA2G2A DDHD2 MAPKAPK2 DDHD1 GNPAT LPCAT4 RXRB PLA2G10 GPD1 GPD1L PLA2R1 HDAC3 SMARCD3 CHD9 NPAS2 HELZ2 ASAH1 TGS1 DHRS7B EP300 INPP5E TBL1X PPARGC1A SLC25A17 NCOA1 CYP11A1 MED1 GC NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 RAB14 TBL1XR1 PLIN2 CARM1 BMAL1 CLOCK SRD5A2 SRD5A1 CYP17A1 PITPNB TAFAZZIN AWAT2 PLD1 PIP4K2A PIP4K2B VAPA MED8 SLC44A5 MED4 MED6 SLC44A3 PTGIS MED7 TBXAS1 VAPB SLC44A4 SLC44A1 MOGAT3 SLC44A2 CYP8B1 STARD3 MOGAT2 STARD4 MOGAT1 ABHD5 STAR STARD6 FABP12 STARD3NL GK3 TSPO GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 ECHS1 GK DGAT1 ACSM3 FABP9 ACSM6 PPP1CA HADH FABP1 ACADS POMC FABP2 FABP3 RAB4A FABP4 FABP5 FABP6 FABP7 GPD2 PLIN3 CAV1 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 MGLL LPIN3 PLA2G3 PLA2G6 PLB1 CGA PLA2G4F TMEM86B PLA2G4E PIP4P1 PNPLA8 PLA2G4C MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 THRAP3 FAM120B NCOR2 RAB5A GPS2 GM2A HSD3B2 CYP11B2 CYP21A2 HSD3B1 CYP2U1 CYP4F2 CYP4A11 CYP1B1 NDUFAB1 NCOA3 GLIPR1 PTGES3 HSD17B1 ORMDL3 PTGES2 ST6GALNAC5 NEU2 NEU3 HEXB NEU1 ALDH3B1 HEXA ST8SIA5 ST3GAL5 GLB1L3 CTSA DEGS1 GLB1L2 GLB1L GLB1 SRD5A3 ARSB GLA PSAP TM7SF2 GGPS1 ARF1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A ACADVL MVK INSIG2 ESRRA SAR1B INSIG1 M6PR ACACB ACACA HADHB PPP1CC PMVK HADHA SCAP SC5D ACADL FDFT1 CDK8 FDPS LHB MBTPS1 SEC24B SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD ACHE SP1 DHCR7 SEC24D ACBD4 HSD11B1 SEC24C HSD11B2 MBTPS2 SERPINA6 PIK3R4 SIN3A BCHE CERK LBR GBA3 GBA2 OSBP GPX2 MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 CHAT PIK3C3 UGCG UGT8 ALDH3B2 SGPL1 B4GALNT1 KDSR TSPOAP1 B3GALNT1 ACER2 FA2H ACER1 ACER3 DEGS2 GAL3ST1 SPTLC1 SMPD4 SPTLC2 SLCO1A2 SPTLC3 A4GALT CERS3 CERS4 TXNRD1 CERS5 CERS6 SPHK2 CERS1 CERS2 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB SPTSSA ORMDL1 HMGCL ACSS3 SGPP2 BDH2 SGPP1 BDH1 SLC22A5 GALC CH25H OXCT1 OSBPL9 OXCT2 OSBPL7 HMGCS2 OSBPL6 HMGCLL1 AACS OSBPL3 ACAT1 OSBPL2 LPGAT1 CPNE7 AKR1B15 HSD17B14 CPNE6 HSD17B11 CPNE1 CPNE3 HSD17B2 PCYT2 PISD PLA2G15 PGP HACD1 PLA1A ABHD4 TECR PGS1 HSD17B3 PTPMT1 HSD17B12 HACD3 OSBPL8 HACD2 OSBPL5 HSD17B8 DGAT2L6 HACD4 CRLS1 HTD2 CDS2 OSBPL10 MORC2 PLAAT1 CBR4 ELOVL1 PLAAT2 ARNT2 OLAH GPCPD1 ELOVL4 PLAAT5 ELOVL2 PLAAT4 ACSL6 PTDSS2 SELENOI MBOAT1 ACSL5 PTDSS1 ACSL4 ETNPPL ELOVL7 ETNK2 ETNK1 ACSL3 TECRL PNPLA3 ACSF3 ACLY PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 MBOAT7 AGT PRKACA PLA2G4A FDX1 FDXR FDX2 MTMR4 LGMN PRKAB2 CSNK2A1 CSNK2A2 CSNK2B TRIB3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 MCEE PIK3R5 PCCA MMAA PCCB MMUT HPGD LTA4H CYP2J2 NRF1 ARF3 AHR SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants HRAS KRAS NRAS SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions BSG SLCO2B1 SLCO2A1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A10 SLC22A12 SLC17A5 SLC25A1 SLC13A2 SLC13A3 SLC16A1 SLCO1C1 SLC44A5 SLC5A12 SLC5A7 SLC10A6 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC13A5 SLC5A8 AVP SLC22A6 SLC16A7 SLC16A8 EMB SLC16A3 SLC22A11 SLCO1A2 SLCO4A1 SLC22A8 SLCO4C1 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 CYP17A1 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation LTF DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o DPM1 DPM2 DPM3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes MCRS1 KMT2A ASH2L KMT2C PHF20 MEN1 OGT KAT2B KAT2A KAT8 PAXIP1 HCFC2 WDR82 BOD1L1 DPY30 MBIP TASP1 KAT14 KMT2D DR1 BOD1 WDR5 TADA2A ZZZ3 HCFC1 YEATS2 TADA3 KMT2B AKAP8L SGF29 PHF20L1 KANSL1 KANSL2 KANSL3 NCOA6 PAGR1 CXXC1 SETD1B SETD1A KDM6A RBBP5 PSIP1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism NT5C ITPA NUDT16 NT5C1A ADPRM NUDT5 GDA DNPH1 NT5C2 NT5E NUDT15 XDH PNP NT5C1B REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NEUROD1 NKX2-2 PAX4 INSM1 NEUROG3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 FOS ATF1 UBB ECSIT NKIRAS1 NKIRAS2 UBC IKBIP MEF2A RPS27A DUSP4 DUSP3 NFKB1 IRAK4 VRK3 MAPK9 NFKBIA DUSP6 MAPK8 DUSP7 MAPK7 TLR10 TLR5 LRRC14 ELK1 USP14 NLRX1 PELI3 PELI2 NFKBIB NLRC5 MAPK10 NOD1 NOD2 AGER USP18 IRAK2 MAPK1 S100A12 N4BP1 MAP3K1 MAPK3 S100B TNIP2 MAP2K1 SAA1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 TP53 ATF2 NFKB2 HMGB1 RPS6KA5 CASP8 UBE2N TIFA TAB3 ALPK1 TAB2 TAB1 IRAK1 PPP2R5D MEF2C TRAF2 RPS6KA3 PELI1 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k ALG1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle CSKMT SDHC SDHD SDHA SDHB SDHAF2 IDH2 SDHAF3 ACAT1 SDHAF1 SDHAF4 ISCA2 ISCA1 CS LYRM4 ACO2 SIRT3 FXN DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication DNAJB11 HDLBP NMT1 DPM1 DPM2 RTN3 DPM3 KPNA1 MAGT1 UBA52 SUN2 HSPA1A MAP1LC3B RRBP1 UBB EIF4E UBC BTF3 RPS27A EIF4G1 NPLOC4 FASN EIF4A2 EIF4A1 HSPA5 EIF4A3 ACOT2 HSPA1B UBE2I IPO7 P4HB KPNA7 BAG2 TUSC3 KPNA4 P4HA1 P4HA2 KPNA5 P4HA3 EIF4G3 SUMO1 KPNA2 HSPA8 EIF4G2 EIF4E3 KPNA3 SCAP TMEM258 VCP SEC11A SEC11C HYOU1 PRKG2 YBX1 DNAJA2 OST4 OSTC ATL2 STT3A KPNB1 STT3B PABPC1 XRN1 NACA XPO1 RPN2 CALR DDOST SPCS3 RPN1 SPCS2 SPCS1 DAD1 PDIA3 APOA1 DNAJC10 VIM DNAJC3 UFD1 CANX METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs BABAM1 H2AC6 BABAM2 H2AC7 UIMC1 ABRAXAS1 BRCA1 UBA52 PSMD14 H2AC17 H2AC12 KAT2B H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 UBB UBC RPS27A STAM EP300 NLRP3 STAMBPL1 STAMBP BARD1 MYSM1 ABRAXAS2 BRCC3 H2AC20 H2AC8 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development MCM2 SMARCB1 LIG1 PLK1 CCNB1 SMARCC1 SMARCC2 ATP6V1E1 ATP6V0B ATP6V1G1 CDH1 ATP6V0E1 CTNNB1 MET ATP6V1B2 ATP6V0D1 CDKN1A ATP6V0C CDKN2A CCND1 ATP6V1A YWHAB MAPK1 ATP6V1H SMARCA2 SMARCA4 MAPK3 ATP6V1C1 BCL2 CDK2 ACTL6A MAPK14 TCF7 GXYLT2 CDH2 STT3B SMARCD3 PXN TERT EDIL3 GSK3B CEACAM1 ZEB1 SIN3A PXDN BIRC7 ASAH1 XPO1 BCL2A1 TBX2 YWHAG EP300 TFAP2A PPARGC1A SMARCD1 CREBBP SMARCD2 ITGA2 SIRT1 LEF1 DIAPH1 TCF7L2 SMARCE1 TCF7L1 TNRC6C TNRC6A TNRC6B YWHAE SERPINE1 CSF1 CDC25B MC4R HINT1 EDNRB QARS1 ZIC1 RPS6KA1 TNFSF11 SOX9 DCT YWHAH TYRP1 TYR FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB PAX3 MITF POU3F2 YWHAZ SOX10 DARS1 MC3R LARS1 KIT TFEC EEF1E1 HDAC1 KARS1 ALX3 IARS1 MARK3 TBX3 POMC UBE2I AIMP1 AIMP2 ACTB MC1R EPRS1 ID1 GMPR MC5R SNAI2 SUMO1 PMEL BCL7A MLANA BCL7C DPF1 MYO5A BCL7B DPF2 DPF3 BRCA1 SS18 SS18L1 RAB27A MYRIP SYTL2 MLPH IRF4 ARID1A GPR143 ARID1B AKT2 SOX2 AKT3 DICER1 TRPM1 WNT3A MOV10 AGO3 AGO4 USF1 AGO1 AGO2 MCM5 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis PPCS PANK2 PANK3 PANK1 DCAKD COASY PPCDC DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 AMER1 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 CTNNB1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 TLE4 APC TLE2 TLE1 TLE5 PPP2R1B PPP2R1A TCF7 AXIN1 ZRANB1 CSNK1A1 GSK3B CTBP2 CTBP1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D TLE3 PPP2R5C LEF1 PSMD8 PSMD6 FRAT1 PSMD7 FRAT2 PSMD2 PSMD3 TCF7L2 PSMD1 TCF7L1 BTRC SKP1 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy CSNK2B MAP1LC3A FUNDC1 ATG12 ATG5 CSNK2A1 ULK1 MAP1LC3B CSNK2A2 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events PRKCB PRKCQ PRKCH RGSL1 PRKCE GNAI3 ADCY4 RGS4 PRKCD PRKCA ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADRA2C ADCY6 GNG3 ADRA2B GNAI1 ADRA2A ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 RGS20 GNAZ RGS17 RGS19 GNGT1 RGS16 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNAT3 GNAS GNB4 PRKCG GNB3 GNB5 ADCY9 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 MAN1B1 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria DYNLL2 MAPK8 BMF SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo LATS1 MOB1B MOB1A LATS2 AMOTL2 DVL2 AMOTL1 YWHAE YWHAB TJP1 NPHP4 CASP3 WWTR1 TJP2 WWC1 YAP1 STK4 SAV1 STK3 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity USP8 HGS LRIG1 EPS15 PTPN2 MET STAM2 SH3GL2 SH3GL1 UBA52 HGF PTPN1 UBB SH3GL3 PTPRJ SH3KBP1 UBC STAM RPS27A CBL SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease FGF9 FGF20 FGF23 FGF16 SOS1 FGF18 FGFR3 PIK3R1 PIK3CA NRAS GAB1 HRAS PLCG1 FRS2 FGF1 FGF2 FGF4 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO2 UBE2I RWDD3 UBA2 SAE1 SUMO1 SUMO3 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) MDH2 NNT KGD4 IDH3G SDHAF2 SDHAF3 ACAT1 SDHAF1 SUCLA2 SDHAF4 FH DLD CSKMT SDHC SDHD SDHA SDHB IDH2 ISCA2 ISCA1 CS LYRM4 IDH3B IDH3A ACO2 SUCLG2 SIRT3 SUCLG1 TRAP1 OGDH FXN DLST SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK GRB2 SOS1 LTK IRS1 TNK2 PIK3R2 ALKAL2 PIK3CA PIK3R1 ALKAL1 PIK3CB ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins CD4 ART1 DEFA1B PRSS3 PRSS2 DEFA6 DEFA4 DEFA5 DEFA3 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation CHUK TASL IRF5 IKBKB IKBKG SLC15A4 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin STAT5A STAT5B PLCG2 RAPGEF1 SOS1 PIK3R1 PIK3CA SHC1 JAK2 PIK3R5 EPOR CRKL NRAS LYN EPO GAB1 HRAS PLCG1 VAV1 PIK3CD IRS2 PIK3CB PIK3CG CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock UBE2D1 F7 FBXL21P SREBF1 PPP1CC CRY2 CRY1 PER2 KMT2A PER1 PER3 ATF2 CRTC2 CSNK1E HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 NPAS2 HELZ2 RAI1 TGS1 BHLHE41 NRIP1 NOCT EP300 KLF15 BHLHE40 TBL1X BMAL2 MEF2D PPARGC1A SIK1 NCOA1 MED1 RBM4 DBP NCOA2 CREBBP CIPC MEF2C NCOA6 NR1D1 SIRT1 NCOR1 TBL1XR1 CARM1 RORC PSMD8 RORB PSMD6 BMAL1 PSMD7 CLOCK PSMD2 PSMD3 PSMD1 BTRC SKP1 FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 SERPINE1 PSMD11 PSMD14 NAMPT PSMD13 CUL1 PSMA7 CDK5 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A TFEB ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PPP1CB PSMC2 AVP PPP1CA RORA CPT1A RXRA PPARA FBXL3 CSNK1D CSNK2A1 CSNK2A2 CSNK2B TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation CHUK IFIH1 RNF135 TRIM25 APP MAVS RIGI NFKB2 RELA NKIRAS1 NKIRAS2 HMGB1 NFKB1 NFKBIA TRIM4 NFKBIB TRAF2 AGER S100A12 MAP3K1 S100B IKBKB SAA1 TRAF6 IKBKG SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) GATA4 PAX6 SPCS3 SPCS2 SPCS1 SEC11A SEC11C PCSK1 ISL1 FFAR1 GPR119 DPP4 GIP DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PHKB GYG2 GYG1 CALM1 PYGB AKR1E2 PYGM PYGL PHKA1 PHKA2 GAA AGL PHKG1 PHKG2 PGM1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins AGT GZMH CMA1 ACE2 REN CTSG ANPEP CPA3 CTSD MME CTSZ ATP6AP2 CES1 ENPEP CPB1 CPB2 ACE REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6A TNRC6B MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C NPAS4 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events PRKAG1 CALM1 PRKAG2 PRKACG PRKAG3 PRKACB RAC1 RPS6KA1 SRC GRIA2 NRAS MAPK1 HRAS GRIN2B MAPK3 RPS6KA6 CASK KPNA2 PRKAR1B GRIA1 LIN7A PRKAR2B LIN7C LIN7B PRKACA GRIA3 GRIA4 GRIN3B GRIN3A NBEA PRKX RASGRF2 CAMK2B ADCY1 RASGRF1 ACTN2 CAMK2D ADCY8 KIF17 CAMK2A GRIN2C NRGN PPM1E PRKAR2A PPM1F GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 PRKAR1A CAMK4 NEFL NRG1 CAMK1 PRKAB2 CAMK2G PRKAB1 CAMKK1 CAMKK2 PDPK1 GIT1 PRKAA1 RPS6KA3 PRKAA2 RPS6KA2 APBA1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development SMAD6 GLI3 SATB2 GLI2 BGLAP MAF HDAC3 SP7 CBFB COL1A1 SRC HES1 YAP1 ZNF521 UCMA RB1 IHH HEY1 HDAC4 ABL1 HEY2 MAPK1 WWTR1 HDAC6 YES1 MAPK3 SMAD1 SMAD4 AR RBM14 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism GOT2 RIMKLB PYCR1 PYCR2 PYCR3 GLUD1 GLUD2 GLUL OAT GLS GLS2 KYAT1 RIMKLA GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis ALDOB PPP2CA POM121C ALDOA PPP2CB NUP42 NUP62 NUP43 TPR NUP88 RAE1 PFKL NUP214 RANBP2 GNPDA1 PRKACG NDC1 NUP210 GNPDA2 NUP155 PRKACB PFKM NUP153 PFKP NUP93 NUP50 NUP35 NUP54 PGK1 NUP37 PFKFB2 PFKFB1 PFKFB4 PFKFB3 GPI NUP107 PGK2 ENO1 GCKR ENO2 ENO3 ENO4 PPP2R1B PPP2R1A PRKACA GAPDHS GCK ADPGK HK2 NUP160 HK1 HK3 NUP85 BPGM HKDC1 SEC13 GAPDH NUP133 PPP2R5D TPI1 PGAM1 PGAM2 PGM2L1 NUP205 POM121 NUP188 ALDOC AAAS RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation PPP1CC CSNK2B FURIN SPCS3 PPP1CB SPCS2 SPCS1 SEC11A SEC11C PPP1CA HSP90AA1 KPNB1 HSP90AB1 XPO1 HSPA8 CSNK2A1 CSNK2A2 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism SIRT1 PPARGC1A ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling TRPC5 TRPC6 TRPC3 NTN1 TRPC4 TRPC1 PITPNA PLCG1 TRPC7 DCC TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA MAPKAPK2 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 ZFP36 EXOSC9 YWHAB EXOSC8 EXOSC3 EXOSC2 EXOSC1 TNPO1 XRN1 DCP1A DCP2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production GATA4 GATA3 PHF21A GATA2 GATA1 RCOR1 HMG20B RAC1 DOCK6 DOCK9 H3-3B ITPK1 H3C8 KIF4B KIF4A AKAP1 H3C15 KIF20A IFNB1 KLC1 KLC4 KLC3 KLC2 DOCK3 ABL1 KIF11 KIF15 ZFPM2 KIF23 KIF22 CDK2 KIF26A VPS45 HBB SIN3A KIF18A DOCK8 DOCK10 DOCK5 DOCK4 HDAC2 JMJD1C IRF1 HBE1 GATA5 IRF2 AK3 MICAL1 CARMIL1 KIF2A HBG2 CDC42 HBG1 EHD1 MAFK KIF2C EHD2 KIF2B EHD3 MAFF RACGAP1 HBD AKAP10 SH2B1 CABLES2 DOCK2 DOCK1 PRKACG PRKACB CENPE MYB ZFPM1 CDK5 MFN1 MFN2 DOCK7 SH2B3 RBSN SH2B2 NFE2 HDAC1 CABLES1 WEE1 CAPZB IFNA5 IFNA4 CBX5 IFNA7 IFNA6 IFNA1 CAPZA1 PRKAR1B IFNA2 CAPZA2 IFNA8 PRKAR2B IFNA21 IFNA14 PRKACA IFNA16 IFNA17 TP53 IFNA10 KIF5C KIF5B KIF5A KIFAP3 PRKAR2A RAB5A KIF28P KIF12 KIF19 KIF13B KIF1C KIF21A PRKAR1A KIF1B KIF21B GATA6 KIF1A KIF25 KIF6 KIF27 RAD51B KIF9 RAD51C KIFC2 KIF16B KIFC1 KIF20B KIF3B KIF3A KDM1A KIF18B JAK2 KIF26B KIF3C MAFG DOCK11 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis ALAS1 CALM1 CYCS SOD2 PPARGC1B SIRT4 POLRMT ATP5F1B POLG2 ACSS2 TWNK SSBP1 IDH2 SIRT3 ESRRA RXRA PPARA ATF2 CRTC2 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 CAMK4 HELZ2 TGS1 HCFC1 TBL1X GLUD1 GLUD2 GABPA SIRT5 MEF2D PPRC1 PPARGC1A TFB1M NCOA1 PERM1 MED1 MTERF1 NCOA2 TFAM CREBBP MEF2C TFB2M NCOA6 NR1D1 NCOR1 TBL1XR1 CARM1 NRF1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs ALOX5 PTGS2 ALOX15 HPGD LTA4H DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU FMO3 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization TCHH TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ LIPN LIPM PRSS8 LIPK TGM5 RPTN CELA2A SPINK6 SPINK5 KAZN LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A LCE6A PKP2 LORICRIN SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 FLG SPRR2E SPRR2F SPRR3 SPRR2G PERP CSTA KLK5 EVPL PPL KLK8 LCE2D LCE3C LCE3D LCE3A LCE3B LELP1 PI3 SPRR2A SPRR2B SPRR2D ST14 CDSN KLK14 LCE3E KLK12 LCE4A SPRR1A SPRR1B JUP KRT4 KRT3 KRT2 KRTAP17-1 KRT8 KRT7 KRT5 KRT9 KRTAP4-11 KRTAP20-1 KRTAP20-2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KRT33B KRTAP5-10 KRT33A KRTAP5-11 KRTAP16-1 KRTAP8-1 KRTAP26-1 KRT24 CAPNS1 KRT23 KRT20 KRT28 KRT27 KRT26 CAPN1 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 KRTAP25-1 KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 KRT14 KRTAP24-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRT1 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 PKP4 KRTAP10-2 FURIN KRTAP10-5 PCSK6 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 DSP DSG1 PKP1 DSG2 DSG3 KLK13 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER SERPINA1 GRIA1 TMED2 CTSC SEC24B SEC24A LMAN1L F5 F8 LMAN1 PREB STX5 SEC22B SEC24D SEC24C TMED10 LMAN2L GOSR2 LMAN2 CD59 MIA3 TGFA MIA2 CNIH1 CNIH2 CNIH3 FOLR1 COL7A1 CTSZ SEC23A AREG SAR1B MCFD2 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MRPL43 MRPL44 TUFM MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 MT-CYB MT-ND6 MT-ND4L MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 MTRF1 GFM2 MRRF MTRF1L MT-ATP6 MALSU1 MIEF1 MTFMT MTIF2 MTIF3 MTRFR MTRES1 MT-ATP8 MT-CO1 NDUFAB1 MT-CO2 MRPS17 MT-CO3 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated PPP2CA VRK3 PPP2CB DUSP6 PPP2R1B DUSP7 MAPK7 PPP2R1A PPP2R5D MAPK1 MAPK3 DUSP4 DUSP3 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling STAT4 STAT3 IL12RB1 IL23R P4HB IL12B JAK2 TYK2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 CHUK NFKBIA ZBP1 RIPK3 NFKBIB NFKB2 MYD88 RELA TICAM1 DHX9 IKBKB TLR3 NKIRAS1 NKIRAS2 RIPK1 IKBKG NFKB1 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs DNAJA1 DNAJA4 PGR DCTN2 DCTN3 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNC1H1 DNAJA2 ACTR1A HSPA1A DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 HSP90AB1 FKBP5 DCTN1 DYNLL1 FKBP4 HSP90AA1 HSPA1B STIP1 HSPA1L DYNLL2 NR3C1 CAPZB NR3C2 DYNC1I2 PTGES3 HSPA2 AR DNAJB1 HSPA8 CAPZA1 CAPZA2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins CDC14A AURKA PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 RB1 PSMC1 PSMC2 FZR1 SKP2 CDK2 NEK2 BUB1B CDC20 FBXO5 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC AURKB SKP1 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD2 FASTKD5 TBRG4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 PNRC2 EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 PPP2R1A RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 PPP2CA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 NCBP1 NCBP2 UPF1 RPS27A EIF4A3 CASC3 MAGOH PPP2R2A RBM8A GSPT2 GSPT1 UPF3B UPF3A MAGOHB RNPS1 UPF2 PABPC1 DCP1A ETF1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 PAK1 ARHGEF6 GNGT1 GNG10 GNGT2 GNG12 CDC42 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants KIT SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors SUMO2 PHC2 PHC1 CBX4 ING2 CBX2 PHC3 NPM1 TRIM28 NCOR2 BMI1 RING1 ZNF350 SIN3A DDX17 CTBP1 RNF2 NRIP1 EP300 MRTFA PPARGC1A NCOA1 ZNF131 NCOA2 CREBBP SAFB PIAS4 PCGF2 DDX5 PIAS3 PARK7 UHRF2 DAXX UBE2I TOPORS CASP8AP2 HIPK2 MBD1 PIAS1 SUMO1 SUMO3 CBX8 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix LAMB3 FURIN CD44 LAMA3 LAMC2 LAMB1 LAMC1 MMP9 KLKB1 DCN BCAN PRSS1 CDH1 CTRB2 CTRB1 CTSV CTSL CTSK BSG MMP13 ADAMTS4 ADAM10 ADAMTS5 ADAM17 ADAMTS1 SPP1 ADAMTS8 ADAMTS9 COL17A1 COL18A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 ADAMTS16 COL25A1 COL23A1 ADAMTS18 NID1 ACAN COL9A1 COL9A3 ELANE COL9A2 CAST CAPNS1 CAPNS2 CAPN2 CAPN1 KLK2 PSEN1 CAPN15 PHYKPL NCSTN OPTC KLK7 ADAM15 MMP20 MMP25 MMP24 CMA1 TPSAB1 A2M MMP10 MMP12 MMP11 MMP15 MMP17 MMP19 CASP3 MMP1 TMPRSS6 CAPN8 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM9 ADAM8 HTRA1 TIMP2 TIMP1 SCUBE3 SCUBE1 MMP8 PRSS2 SPOCK3 CAPN13 CTSG MMP14 MMP16 CAPN14 CAPN11 CAPN12 CAPN10 HSPG2 MMP7 CTSS PLG CTSB MMP3 BMP1 TLL2 CTSD TLL1 MMP2 LAMA5 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism HPRT1 APRT PNP ADA G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC26A1 SLC35B3 SLC35B2 PAPSS2 PAPSS1 SLC26A2 SLC26A11 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C19 CYP2C9 EPHX2 CYP2C8 CYP1B1 CYP2J2 CYP1A2 CYP1A1 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2C19 CYP2E1 CYP2F1 CYP2A7 CYP2C9 CYP2A6 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling ARPC1B ARPC1A CFL1 RASA1 WASL PTK2 KALRN RAC1 LIMK2 LIMK1 SDC2 GRIN1 RHOA ROCK1 ROCK2 ACTG1 PAK1 ARPC4 ARPC5 ARHGEF28 ITSN1 ARPC2 ARPC3 ACTR3 LYN ACTR2 HRAS GRIN2B ACTB CDC42 YES1 TIAM1 FYN TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PPIE COPS3 COPS6 ERCC4 ERCC1 ELL ERCC5 COPS8 LIG1 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 XRCC1 LIG3 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 COPS5 MNAT1 POLK POLE AQR ERCC8 RFC5 RFC3 RFC4 RFC1 RFC2 PRPF19 ISY1 GPS1 PCNA POLD3 POLD4 COPS4 POLD1 COPS2 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 XPA RPA3 COPS7B POLE2 COPS7A POLE3 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport PLB1 LRP1 LRP8 APOM AKR1C3 GPC1 HSPG2 GPC3 GPC2 BCO2 APOA2 SDC4 APOA4 SDC2 RDH11 GPC5 BCO1 SDC3 GPC4 LRP10 GPC6 AKR1B10 LRP12 AGRN LPL APOB SDC1 LDLR LRAT GPIHBP1 APOE APOA1 APOC3 AKR1C1 APOC2 TTR AKR1C4 RBP4 LRP2 RBP2 CLPS RBP1 RETSAT PNLIP TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TLR9 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 TICAM2 TICAM1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 TP53 TLR7 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 MAP2K7 MAP2K6 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ ITGA2B SERPINA1 ALDOA SOD1 FN1 F5 F8 PSAP CD9 EGF CLU PRKCG SERPING1 TF VEGFA PPBP HGF TGFB1 APOA1 LAMP2 PCDH7 PPIA PRKCB CALM1 APP SERPINE1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 CD109 TAGLN2 NHLRC2 STXBP3 TEX264 STXBP2 PDGFB ENDOD1 A1BG APOH VTI1B RAB27B MANF PROS1 A2M APOOL CALU MAGED2 HRG FERMT3 SERPINA3 HSPA5 ORM1 ECM1 OLA1 CTSW ORM2 SERPINA4 TMSB4X TIMP3 GAS6 STX4 ALB QSOX1 AHSG ANXA5 TOR4A CD63 SPP2 LEFTY2 LY6G6F VEGFB VEGFC VEGFD TIMP1 LHFPL2 PCYOX1L TGFB2 F13A1 BRPF3 POTEKP TUBA4A CD36 CFL1 FAM3C ABCC4 APLP2 TMX3 SELENOP SCG3 PRKCA RARRES2 PFN1 CYRIB SELP FLNA SCCPDH ACTN2 LGALS3BP WDR1 PLEK PHACTR2 CYB5R1 SRGN KNG1 MMRN1 PECAM1 CAP1 ITIH4 IGF2 ITIH3 THBS1 IGF1 PLG TTN TGFB3 CLEC3B CDC37L1 CFD ITGB3 ACTN1 FGB FGA VWF FGG TLN1 VCL PF4 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland TGFA EGF AREG FGF10 PRL ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 PRKAR2A ROBO2 PRKACA PRKACG PPP3CB PRKCA PRKACB AKAP5 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE TLR3 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes EP300 FOXO4 FOXO1 BBC3 BCL6 NFYA FASLG STK11 NFYB CREBBP NFYC FOXO3 BCL2L11 DDIT3 CITED2 PINK1 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A1 SLC26A9 SLC26A6 SLC26A4 SLC26A2 SLC26A3 SLC26A7 SLC26A11 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors TNFRSF6B TNFSF18 TNFSF14 TNFSF15 EDARADD EDAR LTA TNFRSF14 TNFRSF1B TNFRSF11B TNFRSF1A TNFSF11 CD27 TNFRSF13B EDA2R CD70 EDA TNFRSF18 TNFSF6 TNFSF4 TNFSF9 TNFSF8 TNFRSF8 TNFRSF4 TNFSF13 TNFRSF17 TNFRSF9 TNFSF13B TNFRSF25 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 RIPK3 PPP2R5D MEF2C TRAF2 UBE2D3 IKBKB BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 RELA RPS6KA1 TICAM1 TANK TRAF3 ATF1 UBB IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 TP53 TLR3 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 CD274 PSMA6 PSMA3 PSMA4 PSMA1 CUL3 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CSNK2A1 ADRM1 CSNK2A2 SEM1 YWHAG CSNK2B RBX1 PSMC5 PSMC6 PSMC3 PSMC4 SPOP PSMC1 PSMC2 CCND1 PSMD8 PSMD6 CDK4 PSMD7 PSMD2 PSMD3 PSMD1 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants DUSP16 MAPK1 DUSP6 DUSP7 DUSP10 DUSP8 DUSP9 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases HCK FLT3LG FYN SYK FLT3 LCK DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors ADORA2B ADORA3 ADORA1 ADORA2A MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling GAB1 MET HGF PIK3CA PIK3R1 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism NT5C ITPA AGXT2 NT5C1A DPYS DPYD NT5M UPP2 UPP1 UPB1 TYMP SAMHD1 NT5E NUDT15 XDH NUDT16 ADPRM NUDT5 GDA DNPH1 ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C2 PNP ENTPD1 ENTPD5 NT5C1B NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase NOS3 NOS1 KCNMB1 KCNMA1 PDE1B PDE2A PDE1A PRKG2 GUCY1A2 GUCY1A1 PDE5A KCNMB2 ITPR1 KCNMB3 KCNMB4 NOS2 IRAG1 PDE9A PDE11A GUCY1B2 PDE10A GUCY1B1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition GXYLT2 CDH2 STT3B PXN EDIL3 SOX2 ZEB1 PXDN SERPINE1 CDH1 ITGA2 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function ATM MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN RMI2 RMI1 TOP3A SEM1 RAD51B RAD51D RAD51C DNA2 BLM RAD51AP1 WRN BRIP1 RBBP8 BARD1 XRCC2 PALB2 RAD50 RAD51 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes CHUK UBA7 UBE2L6 IFIH1 HERC5 FKBP5 TRIM25 ATF6 RIGI HSPA5 IFI6 IFI44L IKBKB ARIH1 EIF2AK3 ISG15 IKBKG IFI27 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome GLI2 PSMA5 PSMA6 PSMA3 PRKACA PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PSMD11 PRKACB PSMD14 PSMD13 CUL1 PSMA7 CSNK1A1 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SUFU PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 FGF9 FGF20 FGF23 FGF16 SOS1 FGF19 FGF18 PIK3R1 PIK3CA FGFR4 NRAS GAB1 FRS3 HRAS KLB PLCG1 FRS2 FGF1 FGF2 PTPN11 FGF4 FGF6 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division PLK1 KIF20A SMC1A PDS5B PDS5A NIPBL KIF23 RAD21 WAPL MAU2 STAG1 SMC3 STAG2 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation BANF1 LIG4 XRCC4 XRCC6 XRCC5 HMGA1 PSIP1 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT GALT RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNK CCNT2 ELL CCNT1 ELOA AFF4 ELOB CDC73 NELFB MLLT1 ELOC MLLT3 NELFCD SUPT6H NELFA IWS1 NELFE EAF1 SUPT16H EAF2 NCBP1 SKIC8 NCBP2 CTR9 CTDP1 RTF1 SUPT4H1 LEO1 PAF1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGLV3-25 IGLV3-27 PTPN6 IGKC IGLV3-21 CD79B IGKV1-39 CALM1 DAPP1 CD79A IGKV1-33 IGHV3-53 IGHM BLNK IGLC7 IGKV5-2 IGKV1-5 IGLC6 IGHD BLK VAV1 SH3KBP1 PIK3AP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 AHCYL1 IGHV3-33 IGKV1D-39 IGKV1D-33 BTK IGKV2D-28 IGKV4-1 PLCG2 IGHV7-81 SOS1 CD19 IGKV2D-30 SYK IGHV4-59 IGHV1-69 STIM1 ORAI2 ORAI1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 ITPR1 IGLV1-44 IGKV3-15 ITPR2 IGKV3-11 ITPR3 PIK3CD IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CD22 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3R1 IGKV2-29 IGKV2-28 IGLC3 NCK1 IGLC1 IGLC2 LYN TRPC1 IGKV3D-20 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis ATM ACD H2AX ATR SPO11 SUN2 TEX15 MSH4 DMC1 MSH5 PSMC3IP LMNB1 MND1 MLH3 H3-3B SYCP2 SYCP1 SYNE2 H3C8 SYNE1 SUN1 TEX12 TERF1 TERF2 SMC1B H2AJ SYCE3 SYCE2 POT1 SYCE1 TERF2IP REC8 STAG3 SYCP3 H3C15 MLH1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 UBE2I H2BC1 CDK4 CDK2 H2AB1 SMC3 H2AC8 H2AC6 H2AC7 MRE11 BRCA1 BRCA2 FIRRM PRDM9 NBN H2AC19 H2AC14 H2BC12L RAD21 H2BC26 TOP3A STAG1 H2BC21 STAG2 RAD51C H2BC17 BLM H2BC12 H2BC13 H2BC14 H2BC15 FKBP6 SMC1A H2BC11 FIGNL1 RBBP8 H4C9 TINF2 RPA1 RPA2 HSPA2 RAD50 H2AZ2 RAD51 RPA3 H2AC20 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation RPL27A KDM8 RPS23 OGFOD1 ZC3H15 RWDD1 RPL8 RPS6 JMJD4 ASPH JMJD7 RIOX1 U2AF2 ETF1 RIOX2 JMJD6 DRG1 DRG2 F9 RCCD1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface PDZD11 ATOX1 ATP7A SLC11A1 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation PRKAR2B CALM1 PRKACA PRKACG ADCY4 NBEA PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A ADCY9 PRKAR1B DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 CYP21A2 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 KHDRBS1 KHDRBS2 KHDRBS3 SFPQ INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport CYGB MB NGB REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 OMA1 PSMD14 PSMD13 OPA1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 ARHGAP10 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins MAGT1 UBA52 UBB UBC RPS27A PRMT1 UBE2I ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 TUSC3 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 SUMO1 MGAT5 ST3GAL4 GSK3A MGAT1 PARP6 MGAT2 GOLGA7 PARP4 TMEM258 ST3GAL1 GALNT1 ST3GAL2 PARP16 PARP9 ST3GAL3 ST6GAL1 PARP14 PARP8 EDEM2 MOGS PARP10 ZDHHC11 MGAT4C ZDHHC9 SRPK2 MGAT4A OST4 SRPK1 MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 OSTC STT3A CSNK1A1 STT3B GSK3B RPN2 DDOST RPN1 DAD1 CANX VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 GRSF1 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A DNAJC3 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors HSPH1 COL1A1 COL1A2 FTH1 FTL IGHV3-23 APOE IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 SCARF1 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 COLEC12 IGKV3-11 MSR1 SCARA5 V2-8 V1-20 MARCO HBB IGKV2D-40 SCGB3A2 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 HMGB1 IGLV2-23 APOB CALR IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV COL3A1 IGKV2-29 COL4A2 IGKV2-28 IGLC3 COL4A1 IGLC1 APOA1 IGLC2 HBA2 V1-9 HSP90AA1 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 LRP1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 SPARC PRDX1 S100A9 ALB SAA1 STAB1 CD36 HYOU1 HP HPR HPX IGHA1 IGHA2 AMBP JCHAIN HSP90B1 CD163 MASP1 STAB2 COLEC11 CD5L SSC5D APOL1 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism SFTA3 CSF2RB SFTPC SFTPD CSF2RA SFTPB ABCA3 SFTPA1 SFTPA2 SLC34A2 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling PPP2CA PPP2CB PPP2R1A UBA52 ANOS1 UBB FGF1 FGF2 UBC FGF3 FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF22 MKNK1 SPRY2 FGF10 MAPK1 MAPK3 FRS2 BRAF PTPN11 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PTK6 PSMC1 CDKN1A PSMC2 CDKN1B CKS1B CCND1 SKP2 CCNE2 CDK4 CCNE1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling CXCL8 VAV1 PAK1 MAPK7 TIAM1 DGKG DGKE DAGLA C5AR1 DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI DGKH RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 GRK3 ARHGEF10L PIK3CG AKAP13 ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 RHOB PDPK1 C3 C5 ARHGEF3 ARHGEF1 ARHGEF2 PIK3CA ARHGEF25 ECT2 CDC42 NET1 ABR ADRA1D ADRA1B ADRA1A GPR176 ARHGEF40 GPR15 PLEKHG2 GPR27 ARHGEF15 GPR25 PLEKHG5 GPR20 ARHGEF19 GPR32 RHOC GPR45 TIAM2 GPR150 OBSCN GPR83 ARHGEF4 GPR84 ARHGEF7 PRKACG NGEF PDE2A PPP1R1B ARHGEF6 FGD1 PDE3A PRKACB FGD2 CCL4L2 RGS8 GNA13 FGD3 PDE8B FGD4 PDE8A TBXA2R PCP2 GRK6 GNA12 ARHGEF33 GPSM1 ARHGEF35 GPSM2 ARHGEF37 PDE4A ARHGEF39 GPSM3 ARHGEF38 PDE4D PLXNB1 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 PDE7B PDE7A OPN1MW CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR2C ADRB1 ADRB2 HTR2A HTR4 TAAR3P GNAT3 HRH1 HTR6 C3AR1 HTR7 RGS9 RGS6 ADCY9 RGS7 HRH2 PRKAR1B HRH4 DRD1 BTK PRKAR2B DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D GNAI3 ADCY4 TAAR5 ADCY3 HTR1B TAAR2 PRKX ADCY2 HTR5A TAAR1 ADCY1 ADCY8 GPR143 GNAQ ADCY7 ADRB3 ADCY6 GNAI1 ADCY5 GNAI2 CAMK4 CYSLTR1 CYSLTR2 GNAZ GNA14 GNA15 GNA11 ADORA2B RGS11 PLCB4 PRKCG KPNA2 GNAL NBEA EGFR RASGRF2 ARHGEF9 CAMKK1 CAMKK2 GABBR2 GABBR1 PRKCB RHO GNAT1 SAA1 GNAT2 PRKCA PLCB3 PLCB1 PLCB2 PRKAR1A PPP3CC MCHR1 ITGA5 TRPC7 TRPC6 TRPC3 SST SRC NRAS SSTR3 MAPK1 HRAS MAPK3 PRKCQ SOS1 RASGRP2 ARHGEF18 RHOA OPN1SW ITGB1 TRIO ITSN1 PREX1 MCF2L ARHGEF16 PPP3CA PPP3CB RASGRP1 PPP3R1 CALM1 CCR5 ARHGEF5 APP ARHGEF26 KALRN MC4R EDNRB CDK5 MCF2 RPS6KA1 EDN1 EDN3 GLP1R VIPR1 MC3R VIPR2 SCT ADM PTH1R GNGT1 PPP1CA POMC GNGT2 MC1R MC5R GLP2R PTH2R GIP MGLL ADCYAP1 CRH IAPP ADCYAP1R1 CGA RAMP2 CALCA TSHB RAMP3 VAV3 CALCB CALCRL PTH GIPR PTH2 CX3CR1 VAV2 PTHLH CRHR1 GHRHR GNG10 PRKAR2A GNG3 CALCR GNG2 GNG5 GNG4 GNG7 GNG8 ROCK1 CXCR4 ROCK2 CXCL12 GCGR SCTR SOS2 GCG GNG12 GNG11 GNG13 ADM2 GNB2 GHRH GNB1 PF4 GNAS PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 VIP GALR3 RAMP1 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR31 RGR CCL13 CCL19 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 HBEGF ANXA1 ADORA2A P2RY4 CCL5 CCL4 CCL1 APLN TAS2R20 RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 PPP2R1B TAS2R40 PPP2R1A TAS2R41 TAS2R42 TAS2R43 LHB TAS2R45 TAS2R46 MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP ADRA2C TAS2R38 ADRA2B TAS2R39 ADRA2A TAS2R60 PTGDR2 CX3CL1 CCR9 PDE3B CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 PPP2R5D NPW CXCR3 CXCR2 NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 PPP2CA TAS2R9 PPP2CB CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 RGSL1 GRM3 GRPR GRM2 EDNRA GRM4 PROK2 GRM7 PROK1 GRM6 UTS2R GPER1 NPFF GRM8 TRHR TAS2R1 UTS2B TAS2R3 AGTR1 TAS2R5 PTGFR TAS2R4 LPAR1 PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR TAS1R2 LPAR5 S1PR3 LPAR6 TAS1R1 NMS S1PR2 NMU S1PR5 GNRH2 TAS1R3 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY AVPR2 BRS3 ACKR3 GPRC6A OXT GPR132 AVP CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR AHCYL1 NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 PRKACA F2RL2 F2RL3 GPR68 PDE1C GPR65 PDE1B PDE1A PMCH RGS4 GRK2 PRKCD RGS5 RGS2 PLA2G4A RGS3 RGS1 GHSR OPRM1 CAMK2B CASR CAMK2D F2R CAMK2A LTB4R2 UTS2 ITPR1 NTS ITPR2 KNG1 AKT2 MCHR2 ITPR3 GRK5 AKT3 TAC3 TAC1 AKT1 CRHR2 OPN4 NMUR2 NMUR1 CAMK2G MLNR TRH LTB4R GRM1 OPRK1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 ARRB1 XCL2 PIK3R3 XCL1 PIK3R2 ARRB2 PIK3R1 RGS18 RGS17 PIK3R6 RGS19 PIK3R5 RGS13 RGS16 P2RY6 P2RY2 RPS6KA3 P2RY1 RPS6KA2 RGS21 CCK HCRTR2 HCRTR1 KISS1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine NAGK AMDHD2 RENBP UAP1 PGM3 GNPNAT1 GFPT2 GFPT1 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis UBE2L6 TRIM25 UBA52 POLK POLE POLH RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 ISG15 RPS27A UBA7 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 USP10 POLE4 PCLAF POLI RPA3 USP43 POLE2 REV1 POLE3 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation CBX6 TNKS2 PHC2 WWP2 EZH2 RNF146 PHC1 FRK CBX4 OTUD3 CBX2 RCOR1 PHC3 RPTOR RRAGA USP7 RRAGC RRAGB BMI1 RRAGD RING1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 RNF2 LAMTOR3 LAMTOR5 SUZ12 MAPK1 MAPK3 ATF2 HDAC3 MBD3 MLST8 EED GATAD2B GATAD2A EGR1 HDAC5 HDAC2 HDAC7 PSMD8 CHD4 RBBP4 CHD3 PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 XIAP PSMD1 MTOR PML TNRC6C PSMA5 TNRC6A SALL4 PSMA6 MTA2 TNRC6B PSMA3 PSMA4 PSMA1 REST JUN PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 ATN1 PSMC1 MAF1 PSMC2 MTA1 HDAC1 MTA3 SNAI2 NEDD4 PPARG TP53 NR2E1 MECOM PTEN AKT2 AKT3 AKT1 CSNK2A1 CSNK2A2 CSNK2B KDM1A SNAI1 MOV10 AGO3 AGO4 PREX2 TRIM27 AGO1 MKRN1 AGO2 USP13 TNKS CBX8 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN DNM2 NOS3 WASL CAV1 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones MEAF6 YEATS4 EPC1 TADA2B H3C8 KAT6A JADE1 JADE3 H3C15 JADE2 KAT7 SUPT20H ATXN7L3 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 ENY2 H2BC9 TAF5L H2BC8 DMAP1 H2BC5 MRGBP TADA1 H2BC3 ING4 ING3 VPS72 H2BC1 MSL2 MSL3 SUPT3H MSL1 TAF6L ACTL6A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 H2AC8 ELP6 H2AC6 H2AC7 ATF2 KAT8 MBIP KAT14 H2BC26 DR1 H2BC21 WDR5 TADA2A EP300 ZZZ3 YEATS2 TADA3 H2BC17 SGF29 H2BC12 H2BC13 NCOA1 H2BC14 H2BC15 NCOA2 KANSL1 CREBBP KANSL2 KANSL3 H2BC11 RUVBL1 CLOCK RBBP7 MCRS1 H2BC18 USP22 PHF20 OGT TAF9 PAX3 TAF12 TAF10 ACTB BRPF1 BRPF3 ING5 KAT5 BRD1 H2AC17 H2AC12 KAT2B RUVBL2 KAT2A H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 ATXN7 SAP130 HCFC1 H4C9 TRRAP EP400 H2AC20 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A EP300 PIP4K2B ING2 PIP4P1 TP53 MAP2K6 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM SLC34A2 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions PTGS1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 TGFBR2 TGFB1 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation HSP90AA1 HDAC6 HSF1 VCP YWHAE HSBP1 RPA1 RPA2 PTGES3 HSP90AB1 RPA3 EEF1A1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism PRKAG2 CSNK1G2 B3GNT3 NOS3 OSBPL1A CYP19A1 FADS2 FADS1 THEM4 PIK3CD PIK3CB PIK3CG UQCRB UQCC3 PIK3CA UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 PRKAA2 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH LYRM4 UQCRQ LYRM7 UQCRC1 UQCRFS1 UQCRC2 CYC1 MT-CYB FXN TIAM2 ACOT8 EHHADH HSD17B4 ACAA1 DECR2 ABCD1 SLC27A2 ACOT4 SEPHS2 SECISBP2 EEFSEC SEPSECS PSTK INMT SARS1 GNMT SCLY STARD5 SLC10A1 SLC10A2 SLC51A SLC51B SLC27A5 CHRM3 GBA1 PTS SPR PDSS2 PDSS1 GCH1 STARD7 COQ9 COQ7 COQ6 COQ5 GCHFR COQ4 HPDL COQ3 COQ2 COQ8B COQ8A GAPDHS TP53 GNAQ ZDHHC21 UGT1A3 SPHK1 CDA GDA PFAS DNPH1 ATIC PPAT TK2 ADSL GNA14 ENTPD2 GNA15 ENTPD3 ENTPD4 ENTPD6 CAD GNA11 ENTPD7 ENTPD8 UMPS GART NT5C2 PAICS DHODH UCKL1 UCK2 NUP205 UCK1 PUDP POM121 NUP188 NT5C1B ADSS1 ADSS2 AAAS POM121C ITPA NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 UGT1A10 ABHD10 UGT2B10 UGT2B11 UGT2B15 RPL4 UGT2B17 RPL5 SLC35D1 RPL30 RPL3 UGT3A2 RPL32 UGT3A1 NAT1 RPL31 NAT2 RPL34 UGT2A3 RPL10L UGT2A2 RPL10A UGT2A1 RPL8 UGT1A1 RPL6 UGDH RPL7 UGT2B4 UGT2B7 RPS15 UGT2B28 RPS14 UGT1A5 RPS17 UGT1A4 RPS16 UGT1A9 RPL18A UGT1A8 RPS19 UGT1A7 RPS18 UGT1A6 RPL36AL RPL36 RPL35 PTGDS RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 ABHD3 PCTP RPS12 CEPT1 RPS9 MFSD2A RPL21 PCYT1B RPS7 CHKB RPS8 PCYT1A RPL23 CHKA RPS5 STARD10 RPL22 RPS6 PHOSPHO1 PEMT RPSA RPL9P9 CHPT1 RPL24 RPL27 CYB5B RPL26 LYPLA1 RPL29 CYGB RPL28 DDAH1 KPNB1 RPS4Y2 RPS4Y1 SMPD3 RPL39L SMPD2 RPL41 GLYATL3 GLYATL2 RPL3L RPS26 GLYATL1 RPS25 ACSM2A RPS28 ACSM5 RPS29 ACSM4 GLYAT TTPA RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A PPA2 RPLP2 HSP90AA1 RPL13A RPS3A GADL1 APIP MRI1 RPL37A CSAD ADO RPL10 TXN2 RPL12 CBS RPL11 ENOPH1 RPL36A MPST RPS27L RPS15A GOT1 TSTD1 BHMT2 RPL14 SQOR RPS3 GOT2 RPL13 RPL15 FMO1 SUOX RPS2 BHMT RPL18 MTAP RPL17 TST ADI1 RPL19 CTH RPL35A ETHE1 RPL23A RPL22L1 SLC25A10 CDO1 FAU RAN RPL26L1 PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 SLC6A7 VNN1 NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT RGL1 ABCC1 ALOX15 CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 PTGR1 SMPD1 ALOX5AP CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ACOXL MECR SLC25A27 UCP3 UCP2 SLC25A14 AGPAT5 PLA2G1B LPCAT1 PLA2G5 PLD6 AGPAT1 AGPAT2 LCLAT1 AGPAT3 AGPAT4 PLD2 LIPI GPAT4 ACP6 LIPH GPAT3 PLA2G2F PLA2G12A PLA2G2D PLA2G2E MIGA2 PLA2G4D MIGA1 PLA2G4B PLA2G2A DDHD2 DDHD1 GNPAT LPCAT4 PLA2G10 GPD1 GPD1L PLA2R1 NMT2 MLXIPL ADIPOQ ADIPOR1 ADIPOR2 ASAH1 COX19 COX17 PLIN2 CS PXMP2 ACO2 NMT1 TIMM21 NDUFB8 TAFAZZIN IDH3G QARS1 VAPA RARS1 ACAD8 HIBADH ACADSB MARS1 ALDH6A1 BCAT1 SLC25A44 BCAT2 DARS1 LARS1 EEF1E1 KARS1 ECHS1 IARS1 ACSM3 ACSM6 HADH ACADS POMC AIMP1 AIMP2 EPRS1 CAV1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 CGA TSHB DUOX2 GSTM1 TPMT ABCC5 NME2 GMPS NME1 IMPDH1 GUK1 GSTA2 IMPDH2 RAB5A GSTA1 HPRT1 CA1 NUDT15 ETFB XDH CA2 CA4 HSP90AB1 KCNG2 BST1 NDUFAB1 KCNC2 GCSH STK11 KCNB1 KCNS3 PGK1 ACY1 SNAP25 VAMP2 STX1A TM7SF2 GGPS1 HMGCS1 ELOVL6 LSS SREBF2 MTF1 MVD IDI1 SEC23A MVK ACADVL INSIG2 SAR1B INSIG1 ACACB ACACA PMVK SCAP SC5D FDFT1 FDPS MBTPS1 SEC24B FOLR2 SEC24A NFYA NFYB NFYC CYP51A1 SQLE GPAM SCD SP1 DHCR7 SEC24D SEC24C MBTPS2 ACY3 GGT7 GGT6 MGST3 MGST1 MGST2 AKR7L AKR7A2 AKR7A3 GGT3P MT-ND6 CYCS MT-ND4 MT-ND5 MT-ND2 SLC22A5 MT-ND3 MT-ND1 ATP5MC2 ATP5MC3 LPGAT1 CPNE7 CPNE6 ATP5MC1 CPNE1 MT-ATP6 CPNE3 PCYT2 ATP5F1A PISD PLA2G15 PGP ATP5F1B PLA1A ATP5MK ABHD4 PGS1 ATP5MJ ATP5MG PTPMT1 OSBPL8 ATP5MF OSBPL5 ATP5ME DMAC2L DGAT2L6 CRLS1 HSPA9 ATP5PF CDS2 OSBPL10 ATP5PD PLAAT1 PLAAT2 GPCPD1 ATP5PB PLAAT5 PLAAT4 SELENOI MBOAT1 ATP5F1C ATP5F1D ETNPPL ETNK2 MT-ATP8 ETNK1 ATP5F1E PNPLA3 FFAR1 ATP5PO AHCYL1 AGT PRKACA ITPR1 ITPR2 ITPR3 KCNJ11 MCEE PCCA MMAA PCCB MMUT FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA TXN MMAB MMACHC MMADHC NRF1 OGDH DLST MCCC2 MCCC1 PPM1K AUH IVD HIBCH STS ARSA SUMF2 SUMF1 TPST2 TPST1 CYP24A1 DHFR2 ARSL PRSS1 ARSJ NADSYN1 FLAD1 CTRB2 ARSK CTRB1 SLC5A8 ARSH BTD ARSI MTHFD1 MTHFD2 ARSF MTHFD2L SHMT1 ARSG HLCS ARSD SLC19A3 PNPO SLC19A1 SLC19A2 CBLIF MTHFR MTHFS TCN1 CD320 MOCS2 MOCS3 QPRT THTPA SLC22A13 NMRK2 PLCG1 RFK NMRK1 CD38 VKORC1 MTHFD1L RNLS TPK1 MOCOS NMNAT3 NMNAT2 NMNAT1 VKORC1L1 ALDH1L1 ALDH1L2 NUDT12 SLC25A51 UBIAD1 NADK SLC52A2 SLC52A3 SLC52A1 GPHN NADK2 NAPRT ACP5 AOX1 SLC25A19 PDXK NAXE SLC25A32 NAXD PPA1 LHPP PIP5K1C ALOX5 PTGS2 SYNJ2 ABCC8 PIK3C2A CYP2R1 TPH2 ASMT AANAT LRP2 CLPS ALPI PNLIP SLC25A18 MDH1 MDH2 SLC25A12 SLC25A11 SLC25A22 SLC25A13 SLC3A2 CES2 PECR PHYKPL CROT SCP2 NUDT19 SLC36A4 GSTK1 PHYH PIPOX BAAT ACOX2 SLC6A12 AGPS SLC7A5 ACOT2 ACOX3 AGXT PAOX DDO HACL1 HAO1 HAO2 EPHX2 NUDT7 AMACR DAO CRAT ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 MED19 MED18 MED11 MED29 MED28 MED22 MED21 MT-CO1 MED13L SLC22A4 SCO2 MT-CO2 MT-CO3 PPARGC1B MED9 CDK19 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 SIRT3 MED23 MED25 MED24 MED20 PPARD ISCA2 ISCA1 CMC1 PYURF SCO1 TMEM126A ALOX12 SUCLG2 SUCLG1 TMEM126B PODXL2 ABHD14B TRAP1 SULT1A1 SURF1 SULT1C2 NDUFAF8 SULT1B1 NDUFAF6 SULT1E1 NDUFAF7 NDUFAF4 BPNT2 NDUFAF5 BPNT1 NDUFAF2 SULT6B1 SULT1A4 SFXN4 NDUFAF3 SULT4A1 SULT1A3 NDUFAF1 SULT1A2 HCCS SULT2A1 TMEM186 SULT1C4 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH DMAC1 DMAC2 PET117 TIMMDC1 PET100 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT SDHC SDHD SDHA SDHB NDUFB10 COX16 NDUFB11 COX18 COX11 MED30 COX14 NDUFV3 NDUFV2 NDUFV1 MED31 COA3 COA1 IDH2 HIGD2A COX20 ETFA TMEM223 IDH3B IDH3A COA5 NDUFC2 NDUFC1 PTPN13 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 CD36 NDUFB5 G6PC1 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 SUCLA2 COX4I1 HGD COX4I2 PTEN TAT FAH HPD ARNT CYP46A1 CYP39A1 RRM2B POR GSTP1 CYP27B1 CYP11B1 NQO1 GSTA3 GCLC GCLM ME1 ABCC3 GPX1 BLVRB BLVRA SLC27A1 CCNC ADHFE1 D2HGDH L2HGDH APOE PCK1 COX7B COX7C CTSL COX8A SREBF1 COX8C COX5B COX5A RXRB COX6C GCK COX6A1 COX6A2 G6PD COX6B2 COX6B1 DHRS7B GLUD1 HIGD1C GLUD2 SIRT5 GC IP6K2 SRD5A2 SRD5A1 CYP17A1 INS RRM2 GLS SAMHD1 NAMPT PIP4K2A PIP4K2B RIDA SDS GAMT SDSL MED8 MED4 MED6 MED7 RAB4A GPI PLA2G3 PLA2G6 PLB1 PLA2G4F TMEM86B PLA2G4E PNPLA8 PIP4P1 PLA2G4C MBOAT2 PLAAT3 LPCAT3 LPCAT2 PLBD1 NCOR2 GPS2 GM2A DHFR TK1 TYMS GLIPR1 ORMDL3 PTGES2 ALDH3B1 DEGS1 GLA PSAP ESRRA CDK8 LHB ACBD4 HSD11B1 HSD11B2 SERPINA6 DMGDH CHDH SARDH ALDH7A1 FMO2 SIN3A FMO3 CERK LBR GBA3 GBA2 OSBP GPX2 MFSD2B ENPP7 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 PLPP1 UGCG UGT8 ALDH3B2 SGPL1 B4GALNT1 KDSR GLS2 B3GALNT1 ACER2 FA2H ACER1 ACER3 DEGS2 GAL3ST1 SPTLC1 SMPD4 SPTLC2 SPTLC3 A4GALT CERS3 CERS4 TXNRD1 CERS5 CERS6 SPHK2 CERS1 CERS2 SAMD8 ASAH2 SGMS1 PPM1L SGMS2 ORMDL2 SPTSSB SPTSSA ORMDL1 SGPP2 SGPP1 GALC CH25H OSBPL9 COX7A2L OSBPL7 OSBPL6 OSBPL3 OSBPL2 AKR1B15 HSD17B14 HSD17B11 HSD17B2 MARCKS IPMK MINPP1 SYT5 MLX ARNT2 GLDC HYKK COXFA4 TDO2 CKMT1B COX7A2 HOGA1 COX7A1 IDO2 IDO1 CACNA1D GCDH OAZ1 OAZ2 ACMSD OAZ3 AFMID RIMKLA RIMKLB PYCR1 PYCR2 PYCR3 SLC6A8 KYAT3 PHGDH AASS ARG2 OAT HAAO SLC2A3 ODC1 CKM QDPR IL4I1 AADAT BBOX1 PAH AGMAT PCBD1 KYAT1 GATM SAT1 ASRGL1 PSPH KMO SMS AZIN2 AZIN1 GRHPR MTMR4 SERINC1 SERINC3 SERINC2 SERINC5 SERINC4 SLC25A2 AMD1 DHTKD1 KYNU AMT ALDH9A1 SRM CKMT2 SRR SLC25A21 CRYM TMLHE PSAT1 IQGAP1 HPGD LTA4H CYP2J2 CYP3A43 AHR CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 GSTT2 CYP1A2 GSTT1 CYP1A1 AHRR OPLAH CNDP2 CYP2E1 CYP2F1 HPGDS ESD CHAC2 CHAC1 GSTT2B GSTM4 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT GSTA5 GSTA4 GSTM5 ABCB7 CIAO3 NUBP1 NUBP2 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B ABCG2 ACOT9 ACOT7 ACOT1 FAR1 FAR2 MCAT PRXL2B HMOX2 ACOT7L PTGR2 PTGS1 G0S2 THEM5 FHL2 FAAH2 ACO1 TNFRSF21 HSD17B13 AWAT1 SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 CPT1B PTGES ALOX15B HILPDA ANKRD1 CBR1 FITM1 FITM2 SLC9A1 GRHL1 CA9 ACAA2 ACOT11 HIGD1A ACOT12 BCKDK ACOT13 BCKDHA DBT ACBD7 BCKDHB ACBD6 DLD ACSF2 DBI CPT2 PON3 PON2 PON1 PRKACG LDLRAP1 PRKACB CUBN AMN APOA2 APOA4 APOA5 ANGPTL4 CES3 LPL LDLR GPIHBP1 ABCA1 NR1H3 APOC3 APOC2 ALB IDH1 RAPGEF3 SLC35B3 RAPGEF4 SLC35B2 HPSE2 UXS1 XYLT2 XYLT1 ENO1 ENO2 HS6ST1 ENO3 ENO4 HS6ST2 HS6ST3 NDST2 NDST1 NDST4 NDST3 XYLB GLCE OMD TALDO1 PHKA1 PHKA2 HSPG2 PPP1R3C NHLRC1 HS3ST3A1 SDC4 SDC2 SDC3 SLC35D2 GNS ABO CHST11 CHST12 CHST15 CHST13 ST3GAL6 CHST14 B4GALNT2 PCK2 DERA EXT1 EXT2 B4GAT1 SDC1 PYGB GBE1 STAB2 AKR1B1 PYGM PYGL MAOB KHK GYS2 GYS1 HYAL2 B3GALT2 B3GALT1 MANBA CHST6 CHST7 TPI1 GAA PGAM1 PGAM2 AKR1A1 PGM2L1 B3GNT7 B3GNT4 FAM20B CHST1 B3GNT2 ALDOC ALDOB ALDOA TKT CHST5 CD44 SPAM1 CHST2 CHST3 PAPSS2 RHD PAPSS1 EXTL2 GPC1 HAS1 HAS3 GPC3 SLC17A5 GPC2 HAS2 GPC5 GPC4 EXTL3 GPC6 AGL GLYCTK LYVE1 FMOD AGRN CHPF NAGLU CHP1 SLC26A11 NOSTRIN GYG2 GYG1 CSGALNACT1 EPM2A CSGALNACT2 AKR1E2 KERA PGD SHPK RHCE PFKFB2 PFKFB1 SLC26A2 PFKFB4 CEMIP PFKFB3 SLC26A1 HMMR FUT2 FUT1 FUT4 FUT3 FUT6 FUT5 ASNS TKFC FUT7 FUT9 DSEL PGK2 GCKR SLC37A1 B3GALT4 CA3 PHKB CA7 B3GALT6 CA6 B3GALT5 G6PC2 BPHL G6PC3 CBR3 NOSIP ABCB4 MAN2B2 AADAC UST OGN SLCO1B1 SLC25A28 CRYL1 SLCO1B3 SLC25A37 GLRX5 MAN2B1 HPSE AOC3 GALK1 AOC2 CMBL B4GALT2 MTARC2 ABCD4 B4GALT3 MTARC1 B4GALT1 ADPGK CA12 NQO2 SLC2A1 HK2 CA14 LMBRD1 CA13 SGSH HS2ST1 ALDH3A1 HK1 EPHX1 HK3 CA5B ABCB11 DSE CA5A PGM2 PGLS MAN2C1 SLC37A4 PGM1 HS3ST3B1 CHPF2 DCXR SORD BPGM HKDC1 ALDH1A1 PXYLP1 LALBA B4GALT6 GAPDH B4GALT7 FBP1 FBP2 RBKS B4GALT4 B4GALT5 ST6GALNAC6 PRPS2 PRPS1 GALT RPEL1 RPE PRELP ACAN UGP2 CHSY1 PHKG1 PHKG2 CHSY3 PRPS1L1 B3GAT3 LUM B3GAT2 B3GAT1 HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 GALNS RPIA PFKL GALE GNPDA1 PC GNPDA2 GALM PFKM PFKP DTYMK AK1 AK2 AK4 GLRX AK5 ADH4 AK6 AK7 ACSS2 AK8 ALDH2 ALDH1B1 AK9 NUDT13 ADH1C RRM1 ADH1B ADH1A NME3 ADH7 CTPS2 ACSS1 NME4 ADH5 CTPS1 ADH6 DCTD NME6 UCP1 CMPK1 DCTPP1 ELOVL3 CIDEA MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP ADA NT5C AGXT2 PARP6 PARP4 NT5C1A DPYS DPYD PARP16 PARP9 NT5M UPP2 PARP14 PARP8 UPP1 UPB1 PARP10 TYMP PRKG2 AKR1C3 PRKCA PLCB3 CYP26A1 PLCB1 PLCB2 CYP26B1 CYP26C1 RDH11 MAOA PRKAR1A ALDH4A1 PLD3 PRODH PRODH2 AIP SLC23A2 CYB5A CYB5R3 SLC23A1 B3GNT5 VDAC1 OXA1L PI4K2B MTMR2 SACM1L PI4KA SBF1 KGD4 INPP5E SLC25A17 CYP11A1 RAB14 NDUFS3 PITPNB SHMT2 PLD1 NDUFA5 HAL AOC1 CARNMT1 UROC1 AMDHD1 HDC CARNS1 LETM1 HNMT FTCD PTGIS TBXAS1 VAPB CYP4F12 CYP8B1 MOGAT3 STARD3 MOGAT2 STARD4 MOGAT1 ABHD5 STAR STARD6 FABP12 GK3 STARD3NL TSPO GK2 PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 GPD2 PLIN3 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 MGLL LPIN3 THRAP3 FAM120B PRKAR2A AKAP5 HSD3B2 CYP11B2 CYP21A2 HSD3B1 HSD17B10 ST6GALNAC5 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CTSA TPH1 SRD5A3 PNMT DDC TH DBH ARF1 M6PR DNM2 HEMK2 NNMT MTRR AHCY GSTO1 MTR MAT1A MAT2B COMT TRMT112 AS3MT MAT2A ADRA2C ADRA2A CACNA1C PIK3R4 PIK3C3 ABCC2 SLCO1A2 WDR26 GLO1 GPT PDHB LDHC RMND5B LDHB LDHA MAEA PDPR RMND5A MPC1 MPC2 PDK4 PDK3 MPC1L NEK1 ME3 DLAT ME2 PDK2 PDK1 PDHX PDHA2 FAHD1 PDHA1 SIRT4 ARMC8 PDP1 MKLN1 GID4 PDP2 GID8 LDHAL6A LDHAL6B TTR PRSS3 CES1 ARF3 MTMR10 TNFAIP8 MTMR12 MTMR14 GDE1 PIK3C2G PIK3C2B TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ENPP6 SBF2 TPTE2 RUFY1 INPP4A INPP4B PI4K2A VAC14 MTMR1 MTMR3 MTMR8 GDPD1 MTMR9 GDPD3 TPTE GDPD5 MTMR6 MTMR7 MTM1 INPP5F INPP5K PIP5K1A PIP5K1B PLEKHA1 PNPLA7 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 FIG4 PIKFYVE PI4KB PNPLA6 IPPK NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K1 NUDT3 IP6K3 NUDT4 STXBP1 GSS OCRL GPX4 ALOX12B ALOXE3 CKB SLC2A2 IDI2 MSMO1 HSD17B7 ACAT2 NSDHL ARV1 EBP DHCR24 PLPP6 LTC4S ENTPD1 ENTPD5 ADCY9 PRKAR1B PRKAR2B PLCG2 WASL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 NT5E GGT1 DPEP2 DPEP1 GGT5 ACBD5 INPPL1 PLD4 INPP5B PLCZ1 INPP5D INPP5J PLCE1 ITPK1 ITPKB ITPKC PLCB4 SYNJ1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PM20D1 ECI1 ACADM DECR1 ACSL1 PEX11A CIDEC ELOVL5 THRSP PNPLA2 HSD3B7 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 PSMD8 CYP7A1 PSMD6 CYP27A1 TCN2 PSMD7 PSMD2 PSMD3 PSMD1 ALAS2 ALAS1 PSMA5 FECH COX15 PSMA6 UROS PSMA3 PSMA4 CPOX PPOX PSMA1 ALAD PSMA2 UROD UBA52 HMBS COX10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB ECSIT PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ACSM1 ACSM2B PIAS4 UBE2I VDR NR1H2 RORA CPT1A RXRA SCD5 SUMO2 PPARG PPARA AGK RTEL1 LRAT BRIP1 POLD1 RBP4 RBP2 RBP1 RETSAT RAP1A MAPKAPK2 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC46A1 HDAC3 SMARCD3 CHD9 NPAS2 HELZ2 TGS1 HMOX1 EP300 TBL1X APOB PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 TBL1XR1 CARM1 BMAL1 CLOCK LRP1 CALM1 LRP8 AWAT2 BCO2 BCO1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 NUDT16 ADPRM NUDT5 GLP1R GNGT1 GNGT2 APOM GNG10 GNG3 GNG2 GNG5 AKR1B10 GNG4 GNG7 GNG8 CYP2U1 CYP4F2 CYP4A11 CYP1B1 GCGR GCG NCOA3 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 HSD17B1 IDUA HEXB NCAN HEXA BGN DCN GLB1L3 GLB1L2 BCAN VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 CSPG5 IDS CSPG4 GUSB ARSB RANBP9 NUP107 HADHB PPP1CC HADHA PPP2R1B PPP2R1A ACADL GLUL CACNA2D2 SLC6A11 ACHE NUP160 LRP10 NUP85 LRP12 BCHE RPS27 CACNB2 CACNB3 SEC13 NUP133 CHAT CYP4V2 CACNA1A CACNA1E PPP2R5D TSPOAP1 PPP2CA PPP2CB NUP43 RANBP2 HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 OCA2 SLC45A2 DCT TYRP1 TYR HACD1 TECR NUP37 HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 PTDSS2 ACSL5 PTDSS1 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 MBOAT7 MIOX ISYNA1 INPP1 INPP5A IMPA1 IMPA2 PLA2G4A ERCC2 FDX1 FDXR FDX2 AKT1 LGMN PRKAB2 CSNK2A1 CSNK2A2 CSNK2B TRIB3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion EZH2 FURIN H2AX PCSK6 ANK3 MDM2 H3-3B H3C8 MTBP ZC3H12A CSNK2A3 H2AJ SRC CTNND1 CDH1 CTNNB1 PCSK7 H3C15 EPS15 CBLL1 ZMYM2 RB1 RACK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 SMARCA4 H2BC1 MPHOSPH8 MAPK3 FOXQ1 H2AB1 TLE1 ZBTB33 POMT2 CTSL H2AC8 H2AC6 PKM H2AC7 DNM2 MYCN TMEM258 POMT1 CDH19 SEC11A KLF9 MCRIP1 SEC11C FOXJ2 STRAP FOXP2 OST4 SP1 OSTC STT3A ZEB1 H2BC26 CTBP2 PIP5K1C H2BC21 CTBP1 EED H2BC17 DDOST TFAP2A H2BC12 SPCS3 H2BC13 SPCS2 H2BC14 SPCS1 H2BC15 DAD1 HDAC2 H2BC11 JUP SIRT1 TCF3 PSMD8 RBBP4 CANX PSMD6 PSMD7 PSMD2 RBBP7 PSMD3 PSMD1 H2AZ2 KMT5A TGIF2 KLF4 TNRC6C PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 FOXA2 PSMA7 TWIST2 TWIST1 PSMB6 PSMB7 BANP PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC ANGPTL4 ARHGAP32 PSMB1 RPS27A ADRM1 SEM1 HEYL PSMC5 SOX10 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HDAC1 PRKCSH SNAI2 GANAB MOGS TCF12 ARID1A H2AC19 H2AC14 H2BC12L MYC ZEB2 CTSS CTSB CSNK2A1 CSNK2A2 CSNK2B RPN2 RPN1 PRDM8 BHLHE22 KDM1A CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 ADAM19 ILF3 CDH11 H4C9 SNAI1 VCL MOV10 AGO3 AGO4 H2AC20 AGO1 ZNF217 AGO2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACADS HADHB HADHA ACADM ACADL ACADVL ECHS1 MECR ACSM3 ACSM6 HADH SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis DDC TPH2 ASMT AANAT TPH1 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c ALG6 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD CSPG5 CSPG4 SDC1 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN DCN GPC6 BCAN VCAN B3GAT3 AGRN PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 DOK1 ARAP1 PTK6 UBB UBA52 UBC AKT1 RPS27A CBL ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 CTDP1 POLR2A POLR2B SUPT4H1 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass UBE2L6 SPRTN TRIM25 VCP UBA52 POLK POLE POLH RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 ISG15 RPS27A RCHY1 UBA7 NPLOC4 RBX1 PCNA POLD3 POLD4 POLD1 POLD2 WDR48 USP1 UBE2B UFD1 CUL4A RPA1 DDB1 RPA2 DTL RAD18 USP10 POLE4 CUL4B REV3L PCLAF POLI RPA3 USP43 POLE2 REV1 POLE3 MAD2L2 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) STAT4 TBX21 NFATC1 IL12RB2 TPST2 CCL3 IFNG RUNX1 TNF RUNX3 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 CHEK1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 XRCC3 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 LTV1 RPL6 RRP1 RPL7 FCF1 RPS15 PWP2 RPS14 RRP9 RPS17 RPS16 IMP3 RPL18A WDR75 RPS19 IMP4 RPS18 SNU13 RPL36AL RRP7A RPL36 PDCD11 ERI1 RPL35 DHX37 RPL38 PNO1 TBL3 RPL37 LAS1L RPS11 MPHOSPH10 NOL11 NOL12 RPL39 RPS10 WDR46 RPS13 WDR43 RPS12 RIOK2 RPS9 RIOK1 RPL21 UTP14A RPS7 UTP14C RPS8 WDR36 RPL23 TEX10 RPS5 GNL3 RPL22 NIP7 RPS6 RPSA HEATR1 RPL9P9 NOL9 RPL24 NOC4L RPL27 NOL6 RPL26 EXOSC10 RPL29 PES1 CSNK1E RPL28 RRP36 UTP6 RPS4Y2 UTP4 RPS4Y1 RIOK3 RPL39L UTP3 WDR18 RPL41 WDR12 BYSL BOP1 TSR1 MPHOSPH6 RPP30 RPL3L FBL RPS26 MTREX RPS25 RPP38 RPS28 RPS27 RPS29 FTSJ3 RPL27A EBNA1BP2 RPS20 RPP21 RPS21 RPP25 RPS24 UTP25 RPS23 ISG20L2 RPLP1 EMG1 UTP20 RPLP0 NOP14 RPP40 RPS4X RCL1 RPL7A RPLP2 RBM28 DDX49 DDX47 RPL13A WDR3 RPS3A NOB1 BUD23 RPL37A PELP1 UTP15 RPL10 UTP11 RPL12 DDX52 RPL11 SENP3 RPL36A UTP18 RPS27L C1D RPS15A DDX21 BMS1 RPL14 RPS3 RPP14 RPL13 DCAF13 RPL15 KRR1 RPS2 RPL18 RPL17 DIS3 RPL19 RPL35A EXOSC7 RPL23A UBA52 EXOSC6 RPL22L1 EXOSC5 FAU EXOSC4 EXOSC9 RPL26L1 EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS27A NOP58 XRN2 NCL CSNK1D NOP56 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions JAK1 HLA-A B2M TUFM IFNB1 YWHAB STAT1 TBK1 IRF3 UBE2V1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 UBE2N YWHAG TAB3 TAB2 PDPK1 TAB1 IRAK1 CREBBP TRAF6 YWHAQ PTPN11 PTPN6 YWHAE BECN1 UVRAG MAP1LC3B YWHAH YWHAZ GJA1 CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 LARP1 IFNA17 SIKE1 MAVS IFNA10 RIGI VPS33A VPS33B G3BP1 G3BP2 HSP90AB1 CNBP NLRP3 SFTPD NLRP12 NUP205 POM121 IL17F IL17A NUP188 AAAS POM121C NUP42 IFNAR1 NUP62 TPR NUP88 RAE1 NUP214 SFN NDC1 NUP210 NUP155 NUP153 NUP93 TYK2 NUP50 NUP35 NUP54 VPS39 STAT2 VPS18 ATG14 VPS11 VPS16 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC SEC23A NUP107 RPS11 SAR1B KPNA2 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 SEC24B SEC24A RPS5 RPS6 RPSA VPS41 VPS45 NUP160 SEC24D SEC24C RPS4Y2 HLA-H RPS4Y1 HLA-C HLA-F NUP85 PIK3R4 HLA-G HLA-E ISG15 RPS26 TOMM70 RPS25 IL17RC RPS28 RPS27 IL17RA RPS29 TLR1 RPS20 TLR2 RPS21 SEC13 RPS24 RPS23 NUP133 PIK3C3 RPS4X HSP90AA1 RPS3A IKBKB RPS27L IKBKG RPS15A MAP3K7 RPS3 CHUK RPS2 NUP43 RANBP2 FAU HLA-B RIPK2 TRAF3 IKBKE RPS27A NUP37 TRIM4 NOD1 NOD2 TJP1 IRAK2 AKT2 TLR8 TLR7 AKT3 AKT1 MASP1 MBL2 IRF7 STING1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT PLK1 DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport PRKACG PRKACB AQP6 AQP4 AQP5 AVPR2 AQP2 AQP3 AVP GNGT1 MIP GNGT2 RAB11FIP2 MYO5B ADCY9 PRKAR1B PRKAR2B AQP10 PRKACA AQP12A ADCY4 ADCY3 ADCY2 AQP11 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A RAB11A ADCY5 GNG2 GNG5 GNG4 GNG7 PRKAR1A GNG8 AQP1 AQP8 GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 AQP9 GNB3 AQP7 GNB5 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 POFUT2 THSD7A ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli FLT4 PANX1 YAP1 CTNNB1 CACNA1H NOS3 RICTOR ABL1 STAT1 CDH5 PPP2R1B PPP2R1A CACNA2D1 SPP1 PRR5 PIK3CD PIK3CB MLST8 CACNB1 CACNB2 PDPK1 CACNB3 ITGB1 PIK3CA IKBKB FYN PKN2 IKBKG MTOR CHUK PPP2CA CALM1 PRKACG PRKACB RELA CAPNS1 CAPNS2 CAPN2 IKBKE NFKB1 NFKBIA KDR ADM GNGT1 GJA1 GNGT2 ADCY9 PRKAR1B PRKAR2B RAMP2 PPP2R2A PIEZO1 PRKACA CALCRL ITGAV ANXA2 MMP14 PTK2 ADCY4 ADCY3 HSPG2 ADCY2 ADCY1 GNAQ ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ADCY5 GNG2 PECAM1 GNG5 GNG4 GNG7 PRKAR1A GNG8 AKT1 CACNG7 ITGB3 MAPKAP1 ITGA5 PIK3R2 P2RY2 GNA11 GNG12 GNG11 GNG13 GNB2 P2RX7 TLN1 PTPN1 VCL GNB1 GNAS GNB4 GNB3 TRPV4 GNB5 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency BTD INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes MEFV HMOX1 NLRP1 CASP1 APP NLRP3 PSTPIP1 NLRC4 NFKB2 RELA AIM2 P2RX7 PYCARD BCL2 TXNIP TXN HSP90AB1 SUGT1 BCL2L1 PANX1 NFKB1 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription HEYL NOTCH1 EP300 NOTCH3 RBPJ MAML2 CREBBP MAML1 HEY1 STAT1 KAT2B HEY2 KAT2A MAMLD1 SNW1 PLXND1 WWC1 FABP7 DLGAP5 PTCRA PBX1 HES1 HES5 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 RHOB RHOC LIN7B RTKN RHOA RHPN2 ROPN1 TAX1BP3 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes SREBF1 RETN INS FBXO32 G6PC1 SOD2 FOXO3 IGFBP1 GCK ABCA6 SIN3A TRIM63 FOXO6 NPY FOXO4 PPARGC1A FOXO1 AGRP HDAC1 ATXN3 HDAC2 PCK1 POMC NR3C1 SMAD2 PLXNA4 SMAD4 SMAD3 SIRT3 CAT RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs H2AX PSMA5 GATA3 PSMA6 ITCH PSMA3 GATA2 PSMA4 GATA1 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MYB PSMA7 H3-3B CBFB PSMB6 H3C8 RUNX1 PSMB7 PSMB4 PSMB5 UBB H2AJ PSMB2 PSMB3 UBC PSMB1 YAP1 RPS27A ADRM1 SEM1 H3C15 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LMO1 H2BC9 LMO2 H2BC8 H2BC5 ABL1 H2BC3 H2BC1 CCNH TP73 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A CDK7 TCF12 MNAT1 TAL1 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 H2BC17 SPI1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 TCF3 LDB1 H4C9 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 H2AC20 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A CDC20 BUB3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBA52 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 UBB ANAPC2 UBC MAD2L1 RPS27A NEK2 BUB1B RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid RARA RXRB PPARD PDK4 PDK3 CRABP1 RXRG AKR1C3 DHRS3 DLAT ALDH1A3 CYP26A1 SDR16C5 PDK2 CYP26B1 PDK1 PDHX CYP26C1 PDHA2 DHRS9 CRABP2 RDH11 RARB PDHA1 ALDH1A2 RDH10 RDH16 RDH5 DLD RDH14 RDH13 ALDH8A1 ADH4 ADH1C ADH1A ALDH1A1 FABP5 DHRS4 RXRA RARG PDHB WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis DHRS7B AWAT1 GNPAT FAR1 FAR2 AWAT2 AGPS DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling PPP1CC SMAD7 TGFBR1 TGFBR2 UBA52 STRAP STUB1 PPP1R15A USP15 MTMR4 UBB TGFB1 PMEPA1 UBC XPO1 RPS27A UCHL5 BAMBI NEDD4L PPP1CB PPP1CA SMAD2 SMAD3 SMURF2 SMURF1 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers DKK2 H2AX DDX46 SMARCB1 DDX42 RBM17 CHD8 MYOG MYOD1 TCF4 H3-3B SMNDC1 U2SURP SMARCC1 SMARCC2 H3C8 H2AJ CTNNB1 H3C15 BICRAL SF3B4 BICRA SF3B5 BRD9 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 H2BC9 SF3A1 H2BC8 SF3A2 H2BC5 ZMYND8 PCK1 PHF5A CHD5 H2BC3 IKZF1 IKZF2 SMARCA2 SMARCA4 PHF6 H2BC1 IKZF3 ZNF687 SNRPN TCF19 ACTL6B ZNF592 ZNF827 CHERP ACTL6A MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 PBRM1 SNRPA1 PUF60 SNRPB2 SNRPD2 SNRPD1 SNRPD3 SNRPG SMARCD3 CHD9 SNRPE ARID2 SNRPF MBD3 SNRPB H2BC26 H2BC21 WDR5 EP300 GATAD2B GATAD2A H2BC17 H2BC12 CHD7 H2BC13 H2BC14 FBP1 NKD2 FAM124B H2BC15 SMARCD1 CREBBP HDAC2 SMARCD2 H2BC11 CBX1 TCF3 MAFK CHD4 RBBP4 CHD3 NFE2L2 RBBP7 SMARCE1 H2AZ2 AXIN2 MTA2 CDC73 SUPT16H SKIC8 CTR9 RTF1 CHD2 LEO1 PAF1 SSRP1 MTA1 HDAC1 MTA3 BCL11B PHF10 UBE2I ACTB CBX3 SUMO1 BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 G6PC1 SS18 SS18L1 TCF12 ARID1A ARID1B H2AC19 H2AC14 H2BC12L NR2C2 IGF2 BCL11A BRD7 NQO1 ADNP2 ADNP CTCF CHD1 CHD6 DHX15 H4C9 H2AC20 ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation NAT1 NAT2 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants ALK PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling EREG PIK3R1 BTC PIK3CA NRG2 HBEGF NRG3 EGFR NRG4 GAB1 EGF ERBB2 NRG1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R2 CYB5R1 CA1 CYB5R4 CA2 HBB CA4 SLC4A1 CYB5RL RHAG AQP1 HBA2 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis FUT2 FUT1 ABO DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 HMGA1 PSIP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination USP8 FZD5 FZD4 WNT3A RSPO3 UBA52 FZD6 RSPO2 FZD8 RSPO1 RSPO4 LRP5 LRP6 ZNRF3 UBB UBC LGR6 LGR5 RNF43 RPS27A LGR4 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 TNRC6A CALM1 TNRC6B PTPN4 GAD1 GAD2 GAMT PVALB GRIA2 FKBP5 SGK1 FOXG1 MET HDAC1 MOBP BDNF GRIN2B CRH PPARG PRKACA DLL1 SLC2A3 HTT NCOR2 OPRM1 CAMK2B CAMK2D HDAC3 CAMK2A PTEN GRIN2A SOX2 SIN3A DGCR8 CAMK4 GPS2 LBR CAMK2G OPRK1 GPRIN1 TBL1X IRAK1 HDAC2 MEF2C RBFOX1 TRPC3 NCOR1 TBL1XR1 HIPK2 PTPN1 MOV10 AGO3 AGO4 AURKB SST AGO1 AGO2 TNRC6C TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) SYT1 VAMP1 VAMP2 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins CYP26B1 CYP26C1 CYP27B1 CYP24A1 CYP26A1 CYP2R1 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines SAT1 PAOX DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 MDM2 PSMA7 PSMB6 PSMB7 MTBP PSMB4 BANP PSMB5 UBB PSMB2 PSMB3 SRC UBC CTNND1 PSMB1 RPS27A ADRM1 CDH1 SEM1 CTNNB1 EPS15 PSMC5 CBLL1 PSMC6 PSMC3 PSMC4 PSMC1 RACK1 PSMC2 CTSL DNM2 CTSS CTSB CTNNA1 JUP PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle SIRT5 SLC25A15 ARG2 CPS1 ARG1 ASL TP53 NAGS ASS1 SLC25A2 NMRAL1 OTC ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus JAG2 JAG1 ITCH ADAM10 DTX4 DLL1 MIB1 DLL4 NEURL1B UBA52 ADAM17 NEURL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B CNTN1 NOTCH1 ARRB1 ARRB2 DNER DTX1 NUMB DTX2 DLK1 MIB2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes H2AC6 H2AC7 H2AX PLK1 CCNB1 H3-3B H2AC19 NCAPH2 CDK1 NCAPG2 H2AC14 H3C8 H2BC12L NCAPD3 SMC4 H2AJ SMC2 H2BC26 H2BC21 MCPH1 H3C15 H2BC17 RB1 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 SET H2AB1 H2AZ2 H2AC20 KMT5A H2AC8 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration MMP13 CBFB ITGBL1 AKT2 ITGA5 AKT3 AKT1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies HMGCS2 HMGCLL1 AACS ACAT1 HMGCL ACSS3 BDH2 BDH1 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs POM121C NUP42 NUP62 NUP43 TPR BANF1 NUP88 RAE1 KPNA1 NUP214 RANBP2 NDC1 NUP210 NUP155 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA ZNF473 SNRPD3 NCBP1 SNRPG NCBP2 CPSF1 CSTF3 CPSF4 SNRPE CPSF3 CSTF2 CPSF2 SNRPF CSTF2T WDR33 SNRPB NUDT21 PCF11 CLP1 CSTF1 FIP1L1 PAPOLA SYMPK CPSF7 LSM10 SLBP LSM11 PABPN1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2AC6 H2AC7 H2AX MTA2 H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ MBD3 H2BC26 H2BC21 TTF1 ERCC6 H3C15 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 MTA1 H2BC15 HDAC1 HDAC2 EHMT2 MTA3 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AB1 H2AZ2 H2AC20 CBX3 H2AC8 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase ADCY1 ADCY8 PRKAR2B PRKAR2A CALM1 PRKACA PRKACG PRKAR1A PRKACB PRKX PRKAR1B CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT NFATC3 NFATC2 NFATC1 FKBP1A CALM1 PPP3CA PPP3CB PPIA PPP3R1 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) HTRA2 DNAJA1 HSPA9 LONP1 HSF1 DEFA5 SOD2 FOXO3 HSPA1A HSPA1B HSPE1 ESR1 ATF5 HSPD1 AKT1 SIRT3 NRF1 CAT DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 CASP8 TNFRSF10B TNFRSF10A TNFSF10 FAS FASLG TRAF2 RIPK1 FADD TRADD ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling PTK6 EGF EREG BTC ERBB2 NRG1 NRG2 HBEGF NRG3 NRG4 EGFR INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling HLA-DRB3 FCGR1BP PTPN6 HLA-DRB1 CIITA OASL CD44 TRIM68 GBP1 TRIM62 OAS1 OAS3 TRIM21 IRF8 IRF6 IFNGR1 IRF9 IFNGR2 TRIM46 TRIM48 JAK1 HLA-B GBP3 HLA-A TRIM45 B2M HLA-DPA1 TRIM35 TRIM38 TRIM31 TRIM34 HLA-DQB2 HLA-DQB1 IRF5 SOCS3 SP100 MAPK1 NCAM1 MAPK3 HLA-DPB1 PIAS1 PTAFR SUMO1 SMAD7 TRIM25 IRF3 GBP6 YBX1 PRKCD IRF4 CAMK2B CAMK2D CAMK2A HLA-DRA IFI30 HLA-H IFNG HLA-C ICAM1 HLA-F TRIM29 TRIM26 HLA-G TRIM22 HLA-E GBP5 GBP7 CAMK2G TRIM17 TRIM14 TRIM10 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 SOCS1 JAK2 IRF1 IRF2 HLA-DQA2 HLA-DRB5 IRF7 MID1 FCGR1A OAS2 HLA-DRB4 MT2A VCAM1 RAF1 GBP2 GBP4 PTPN1 PTPN11 PML GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport TMED2 ARF4 ACTR1A SEC22B RAB1A TMED10 COPZ2 COPZ1 GALNT2 RAB1B KIF4B KIF4A KIF20A KDELR3 KLC1 KLC4 KLC3 DCTN1 KLC2 KIF11 KIF15 AGPAT3 ARF1 KIF23 KIF22 NSF KIF26A DCTN2 DCTN3 DYNC1LI1 DYNC1LI2 ZW10 RAB18 RAB3GAP2 RAB3GAP1 GBF1 TMED3 TMED7 TMED9 KIF18A COPG2 COPG1 COPB2 COPA COPB1 DYNLL1 COPE DYNLL2 ARFGAP1 KIF2A KIF2C KIF2B RACGAP1 PAFAH1B1 DYNC1I2 ARFGAP3 DYNC1I1 NAPA DYNC1H1 NAPB CENPE DCTN6 DCTN5 NAPG DCTN4 BICD1 BICD2 CAPZA3 ACTR10 PAFAH1B3 PAFAH1B2 RAB6A RAB6B CAPZB CAPZA1 CAPZA2 PLA2G6 GALNT1 ARF5 KIF5C PLA2G4A ARCN1 KIF5B KIF5A KIFAP3 KIF28P KIF12 USE1 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF1A KDELR2 KIF25 KIF6 KIF27 RINT1 ARFGAP2 KIF9 KIFC2 KIF16B KIFC1 KIF20B KIF3B KDELR1 KIF3A NBAS STX18 BNIP1 SURF4 KIF18B KIF26B KIF3C ARF3 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation AHCTF1 NUP62 RCC1 NUP43 SEC13 NUP133 NDC1 NUP155 RAN NUP93 RANGAP1 NUP35 UBE2I NUP54 NUP160 KPNB1 NUP85 TNPO1 NUP205 POM121 NUP107 NUP188 NUP37 SUMO1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis GSK3A MAPK1 MAPK3 RNF213 CTSG TRIM27 SFPQ BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism MCCC2 PCCB ACACA MCCC1 BTD PDZD11 HLCS PC SLC5A6 PCCA ACACB MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB7 ABCB6 ABCB10 ABCB8 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN TNKS2 TNKS SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste TAS2R40 TAS2R8 TAS2R41 SCN9A TAS2R43 SCN1B TAS2R46 GRM4 OTOP1 TAS2R1 TAS2R30 CALHM3 PLCB2 TAS2R3 TAS2R31 TAS2R5 TAS2R4 TAS2R38 TAS2R39 SCN3A ITPR3 SCNN1G TAS1R2 SCNN1D TAS2R50 SCNN1B TAS1R1 SCNN1A GRM1 SCN2A TAS1R3 SCN2B KCNJ2 TRPM5 TRPM4 SCN4B GNG13 TAS2R20 GNB1 GNAT3 TAS2R10 CALHM1 TAS2R13 GNB3 TAS2R14 TAS2R7 TAS2R16 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery RPS10 RPS2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 FAU RPS6 RPSA RPS4Y2 RPS4Y1 RPS27A RPS26 RPS25 RPS28 RPS27 HNRNPA1 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS15 RPS14 RPS17 RPS16 RPS19 RPS3A RPS18 RPS27L RPS15A RPS11 EEF1A1 RPS3 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly COX8C SMIM20 COX15 COX5B TIMM21 COX5A RAB5IF COX6C COQ10B COQ10A COX7A2L TMEM177 HIGD1A COX4I1 COX4I2 COX6A1 COX6A2 PET117 PET100 COX6B2 TACO1 COX6B1 MT-CO1 COX16 COX19 COX18 COX17 COX11 COX14 COA3 COA1 HIGD2A COXFA4 COX20 COX7A2 SCO2 COX7A1 TMEM223 COX7B CMC1 COA5 SCO1 MT-CO2 COX7C MT-CO3 COX8A SURF1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function CDKN2A C1QBP PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CRY2 BHLHE40 CRY1 PER2 KMT2A PER1 PER3 SIK1 RBM4 DBP CREBBP CIPC NR1D1 RORA CRTC1 RORC BMAL1 CLOCK NPAS2 TFEB CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHG3 IGHG4 IGHG1 IGHG2 FCN1 FCN2 FCN3 MASP1 MBL2 CRP C1QB C1QA COLEC11 COLEC10 C1S C1R C1QC BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis B3GALT5 ST3GAL3 RHD RHCE ST6GALNAC6 B3GALT2 B3GALT1 FUT2 FUT1 FUT4 FUT3 FUT6 ABO FUT5 FUT7 FUT9 ST3GAL6 B4GALNT2 B3GALT4 ST3GAL4 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence MCM2 TERT BRCA1 LIG1 MCM5 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions IL11 CNTFR CNTF OSMR IL31RA IL31 OSM CTF1 JAK2 CLCF1 IL11RA LIF TYK2 LIFR JAK1 CRLF1 IL6ST SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways DKK1 DKK2 EZH2 DKK4 PYGO1 H2AX PRKAG1 PYGO2 PRKAG2 TMED2 SFRP1 ASH2L SFRP2 CSNK1G2 BCL9L BCL9 CCDC88C PRKAG3 CHD8 USP34 RAC1 CBY1 RSPO2 SOST JAK1 RSPO1 RSPO4 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 CXXC4 FOS LRP6 ZNRF3 VAV1 WIF1 SRY H2AJ SCFD1 RYK LGR6 LGR5 LGR4 YAP1 DERL2 SHB SH2D2A H3C15 NOS3 PAK1 OS9 SPOP RICTOR PAK3 PAK2 KLC1 SUZ12 H2BC9 KLC4 H2BC8 KLC3 H2BC5 KLC2 STAT1 H2BC3 STAT3 MIB2 H2BC1 FOSB CD86 CD80 H2AB1 GRAP2 TLE5 H2AC8 DGKG H2AC6 DGKE H2AC7 DAGLA MYCN DGKD DGKB CD274 DGKA VCP ABHD6 ABHD12 PRKCH PRKCE SEL1L TCF7 DGKZ DGKQ THEM4 DAGLB DGKK DGKI DGKH FGFRL1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 PRR5 RXFP3 RTKN GSK3B SOWAHC PIK3CD DPY30 ARHGEF10L STK10 PIK3CB AKAP13 PIK3CG SLK H2BC26 H2BC21 ARHGEF11 MLST8 ARHGEF10 WDR5 ARHGEF12 YWHAG ARHGEF17 STARD8 EED PDPK1 RHOB CIT H2BC17 DAAM1 ARHGEF3 H2BC12 ARHGEF1 H2BC13 ARHGEF2 H2BC14 PKN3 H2BC15 PIK3CA ARHGEF25 ARHGEF28 LCK IQGAP3 STOM RHPN2 H2BC11 PRKAA1 ECT2 PRKAA2 STARD13 JUP LEF1 CAVIN1 CDC42 PCDH7 MYO9A ERLEC1 NET1 RBBP4 ANLN RBBP5 FYN DIAPH1 ACTC1 CSK RBBP7 DLC1 PKN2 TCF7L2 PKN1 H2AZ2 TCF7L1 ADRA1D ADRA1B PTPN11 MTOR ADRA1A TNRC6C ARHGEF40 GPR176 PLEKHG2 GPR15 GPR27 PTPN6 ARHGEF15 PLEKHG5 GPR25 TNRC6A GPR20 ARHGEF19 TNRC6B GPR32 RHOC TIAM2 GPR45 CCNK OBSCN CCNT2 GPR150 ARHGEF4 GPR83 ARHGEF7 CCNT1 GPR84 NGEF PDE2A ARHGEF6 PPP1R1B FGD1 PDE3A FGD2 CCL4L2 GNA13 NELFB RGS8 FGD3 PDE8B FGD4 PDE8A PCP2 TBXA2R GRK6 GNA12 GPSM1 ARHGEF33 TBP GPSM2 ARHGEF35 ARHGEF37 NCBP1 PDE4A GPSM3 ARHGEF39 NCBP2 ARHGEF38 GTF2A1 PDE4D PLXNB1 GTF2A2 PDE4C RGS14 PDE11A RGS20 RGS22 PDE10A RGS10 RGS12 PDE7B PDE7A KDR CDK9 PTK6 CHRM2 CHRM3 GJA1 CHRM1 CHRM4 CHRM5 HTR2B ACTB HTR2C ADRB1 ADRB2 HTR2A SCAI HTR4 TAAR3P HRH1 HTR6 HTR7 RGS9 HRH3 RGS6 HRH2 RGS7 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D TP53 HTR1A ARL2 TAAR5 HTR1B ROPN1 TAAR2 HTR5A TAX1BP3 TAAR1 NF2 CCT6A GNAQ PRC1 GPR143 ZDHHC7 ADRB3 CRABP2 ZDHHC21 PPID CAV2 MMP7 UGT1A3 TUBA1B PPP5C CCT2 SPHK1 KDM4A GNA14 CTNNA1 GNA15 GNA11 CCT7 SNAI1 PLXND1 WWC1 DLGAP5 PTCRA PBX1 TACC3 RGS11 FNTA FNTB AAAS RCOR1 JAK3 TYK2 S1PR1 KPNA2 STRAP RPS6 FLT1 LYPLA1 SPPL2B HSPB1 SPPL2A SMPD3 SMPD2 CLIP3 TAX1BP1 TGFB1 NSMAF BAD OTULIN CASP9 ABHD17C USP17L2 ABHD17B ABHD17A RCE1 CPNE8 DOCK8 FNBP1L FNBP1 SCRIB NIPSNAP2 RHOJ CLTC CDC42BPB CDC42BPA SLC4A7 CLTA FMNL3 SPINT1 MST1 HPN HSP90AA1 SPINT2 PARP1 MST1R PGF CDC73 FST FOXH1 DRAP1 CBFB RUNX1 LEO1 ADAM12 IER3 FASN PHLPP2 PHLPP1 ATN1 MAF1 RPS6KB2 WDR83 RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 AXL SHOC2 SEPTIN7 CDC14B RASGEF1A ETV4 IGF2BP1 MAPK6 MAPK4 ANGPT1 TEK SRRM1 DDX39B ANOS1 SOX2 MATK WNT5B ROR1 ROR2 SUFU TRPC7 TRPC6 TRPC3 LAMA5 LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 HHIP BOC GAS1 CDON UBE2D2 PLD2 PRKCQ MEMO1 NRG2 NRG3 RASGRP2 NRG4 RASGRP4 PXN TERT TAB3 DDX4 TAB2 TAB1 GFAP CFTR TRAF6 AXIN2 CCR5 MC4R EDNRB RPS6KA1 MAGED1 SOX9 YWHAH EDN1 EDN3 YWHAZ MC3R KIT RAC2 HDAC1 S100A9 S100A8 MARK3 POMC RHOT1 MC1R ID1 MC5R SNAI2 CAV1 CGA TSHB VAV3 VAV2 CX3CR1 IGF1R HSP90AB1 ROCK1 ROCK2 GPS1 TWF1 MSI2 RHOBTB1 ACTG1 SNX3 RHOBTB2 TRA2B MYO6 STK38 RBBP6 RNF20 SPEN CPSF7 TMOD3 ACTN1 TXNL1 COPS4 COPS2 CDC37 PHIP PDE5A VIM HNRNPC RBMX DBN1 FURIN PCSK6 PCSK5 TGFBR1 TGFBR2 CAB39L RPTOR STK11 EEF2K STRADA STRADB TSC2 TSC1 PPM1A RRAGA RRAGC RRAGB RRAGD AKT1S1 CAB39 EIF4EBP1 PGK1 SLC38A9 EIF4E EIF4B RHEB LAMTOR2 LAMTOR1 ITGB5 LAMTOR4 LAMTOR3 EIF4G1 LAMTOR5 MYLK MYL12B MYH11 APC ANXA1 TPM4 TPM3 RAB4B MYL6 PTPN12 LFNG GPAM ZRANB1 SCD SP1 MUC13 DLG1 DLG3 DLG4 TRADD UBE2L3 CASP8 THBS2 FLOT1 TNFSF10 FLOT2 TRAF2 GALNT3 BIRC2 BIRC3 MUC20 XIAP RIPK1 FADD ELANE TNFRSF10B GZMB TNFRSF10A ITCH NPFFR2 NPFFR1 FAS RGSL1 GRPR BAX STUB1 EDNRA PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 HCRT NTSR1 SAMM50 NTSR2 GPR17 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 QRFP MTX1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 CCKBR NPSR1 GRP PTGER1 PTAFR AHCYL1 NPS PROKR1 ATP2A3 PROKR2 ATP2A2 KISS1R ATP2A1 P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 PRKACA F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CAMK2B CASR CAMK2D F2R CAMK2A LTB4R2 UTS2 ITPR1 NTS KNG1 ITPR2 MCHR2 GRK5 ITPR3 TAC3 TAC1 OPN4 NMUR2 NMUR1 CAMK2G MLNR TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 RPS6KA3 P2RY1 RPS6KA2 RGS21 CCK HCRTR2 HCRTR1 KISS1 MAPKAPK5 PTN ZAP70 ALKAL2 ALKAL1 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 AMER1 PHC3 GLI1 KIF7 IL6 MDM2 GPR161 INTU TULP3 CXCL8 FUZ BMI1 ADCY10 RING1 RNF2 MAPK8 MAPK7 CDKN2B ICMT H3-4 NTRK2 DOCK3 BDNF GAB1 FRS3 GRIN2B NTF4 TIAM1 SORCS3 NTF3 PLCG1 EGF BCL2 AREG BCL2L1 C5AR2 C5AR1 JAG2 JAG1 ADAM10 CD19 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 ITSN2 GRK3 PIP5K1C CFLAR C3 C5 PLAT PICALM EPS15L1 EPN1 CTTN ARF6 EVC2 IQCE EFCAB7 EVC DRC4 TRIP10 SLC1A5 KLK3 KLK2 KDM4C IDE DHRS4 ST3GAL4 GOLGA7 ST3GAL3 ZDHHC9 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 CAMK4 NEFL HNRNPA1 MYH9 RBPJ BCAP31 MYL9 GATA3 SFN MMP9 SFPQ COL1A2 HNRNPM HNRNPF HEY1 CASP10 HEY2 DUSP16 PTBP1 PPARD EGFR SPP1 MBD3 HHAT USP9X DISP2 SCUBE2 PTPRK HNRNPH1 GATAD2B LRIG1 FAM83D GATAD2A SKI PAG1 FAM83A SPRY1 UBE2D3 YY1 RHOT2 RAP1GDS1 MFN1 MFN2 MYO19 TRAK2 DOCK7 TNS4 TNS3 MRTFA KMT2B FOXO6 FOXO4 FOXO1 SOCS3 SENP1 PTPN18 PTPN13 PTPN7 PTPN2 TNFRSF10D PIN1 MECOM PTEN ITGA5 SRF STAP2 E2F4 E2F5 PTPN1 SST IL2RA CCL2 TRIM33 CCNC MYOG MYOD1 MYF6 TCF4 MYF5 TGFA RACK1 APOE PCK1 FARP2 SMARCA4 SNW1 CDH5 TLE1 RXRB PARD6B RXRG VEGFA PTPRO MAMLD1 PRDM1 EGR1 IRAK1 IL2 IL3 BMP2 TCF3 ULK3 DZIP1 CHD4 CHD3 SPOPL YWHAQ TGIF1 TGIF2 INS MTA2 REST KRAS MAML2 MAML1 SERPINE1 MYB PIP4K2A PIP4K2B JUNB RNF111 NEDD4L GGA3 TIAL1 TIA1 RBFOX2 ESRP2 RAB4A RET RARG ULK1 GLI3 GLI2 RSPO3 TCF12 NCOR2 KAT2B UACA KAT2A RARB IRS4 IGF2 IGF1 GPS2 WWOX SYVN1 WWP1 KDM3A KDM1B APOD ARL4C EEPD1 MRGPRD PTPRJ CMKLR1 PF4 PDYN AGTR2 FPR1 CSF2 FPR3 GALR3 GALR2 ITGA2B GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR MEN1 CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 USP7 PLPPR4 PLPPR5 CCL19 USP2 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 FKBP5 GPHB5 CXCL13 NOTCH2 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A NOTCH3 MTNR1B PSAP CXCL10 CXCL11 NOTCH4 ECE1 ECE2 PRLHR ADORA2A ABL1 CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN TAS2R20 SKIL RRH OXER1 PTGDR TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR37L1 TAS2R19 KEL TAS2R40 TAS2R41 TAS2R42 CDK8 TAS2R43 LHB TAS2R45 TAS2R46 NLN MC2R PENK PPY CCR10 CCR1 TAS2R30 TAS2R31 PPBP TAS2R38 TAS2R39 TAS2R60 PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 SIN3A CCR4 CCR3 OXGR1 LBR CCR2 TAS2R50 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 HDAC5 CXCR5 CXCR6 HDAC2 CXCR1 NPW CXCR3 CXCR2 PRLH HDAC8 MAS1 HDAC9 XK HDAC6 NPY2R HDAC7 CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 PML CXCL6 TAS2R9 CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 CXCL5 HDAC10 HEBP1 GRM3 HDAC11 GRM2 GRM4 GRM7 GRM6 GPER1 GRM8 RUNX3 TAS2R1 TAS2R3 TAS2R5 TAS2R4 PTGIR NPY5R SSTR1 SSTR2 SSTR4 AATF SSTR5 CORT CITED1 NPY4R OPRL1 CNR2 CNR1 PRDM4 TAS1R2 S1PR3 TAS1R1 PRMT1 S1PR2 S1PR5 TAS1R3 SGK1 S1PR4 TSHR ACKR4 NPY ACKR3 ACKR2 ACKR1 STEAP3 ATP1B4 KCTD6 CAPZB SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMURF1 TIMP2 SMAD6 TIMP1 ESR2 HELLS SMAD7 TGFB2 NR4A1 INHBA KLF16 ACVR2A TGFBR3 MMP14 MMP16 GIPC1 NR2E1 INHA YBX1 CASP2 AXIN1 OPRM1 PPP1R15A USP15 RBL1 LTBP4 LTBP2 LTBP3 MTMR4 LTBP1 ITGB8 THBS1 PMEPA1 ITGB6 ERBB2 HES1 TGFB3 UCHL5 BAMBI ITGA8 USP8 OPRK1 PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 PORCN ARRB2 KHDRBS1 RAP1B JAK2 KHDRBS2 KHDRBS3 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 VCL MAP3K11 DNAJB1 BAG4 TFRC TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A NEDD8 ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 TBK1 DTX4 EPO DBT DLD STK4 SAV1 STK3 LATS1 MOB1B MOB1A LATS2 AMOTL2 AMOTL1 LTK TNK2 COL4A2 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 PELP1 COL9A1 COL6A3 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 AP2A1 AP2A2 TNF PRKACG PRKACB AP2M1 MYLIP TNFRSF1A FCER2 SPARC ANGPTL3 ABCG1 CETP PDGFB AP2S1 ABCA1 APOC4 NR1H3 AP2B1 APOC2 APOC1 P4HB RAPGEF3 RAPGEF4 VEGFB VEGFC VEGFD CFL1 PLG ST3GAL6 AAMP BCAR1 GRB7 STMN2 KIF14 RND1 STIP1 EPSTI1 WDR6 PLXNA1 FAM83B ANKRD26 DST RRAS2 ALDH3A2 TMEM59 CCDC88A FAM135A VANGL2 UBXN11 DLG5 CPD PKP4 GPC5 B4GALT1 WLS PDGFD CILP MXD4 VPS29 VPS35 CSN2 TMED5 THBS4 THBS3 STMN1 ALDH1A1 VPS26A ADAP1 BEX3 ARHGAP39 SRGAP3 LIMK2 SRGAP2 LIMK1 SRGAP1 MYH14 MYH10 IKBKE OPTN ADH4 ADH1C ADH1A FLT3LG MTA1 MTA3 DNER TLE4 TLE2 DTX1 DTX2 DLK1 RNF31 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 ABCG8 ABCG5 GSK3A GNAT2 CRABP1 PRKG2 PRKG1 AKR1C3 PRKCA DHRS3 ALDH1A3 PLCB3 CYP26A1 PLCB1 PLCB2 SDR16C5 CYP26B1 NLK CYP26C1 PDE6B DHRS9 PDE6A RDH11 PDE6G GNAO1 ALDH1A2 RDH10 RDH16 ALK RDH5 RDH14 RDH13 PRKAR1A ALDH8A1 STRN ARHGAP10 PPP3CC IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA RAG2 RAG1 CSNK1E CSNK1A1 ARHGEF18 CGN F11R PRKCZ RHOA PARD6A PARD3 GFRA1 OPN1SW RPS6KA5 GDNF ARL13B ID4 PDE6D ITGB1 CYFIP1 DOCK5 ANKLE2 SRMS DOCK4 TRIO ITSN1 ARHGAP1 ARHGDIG ARHGAP5 ARHGAP35 PREX1 OPHN1 ARHGDIA STBD1 MCF2L ARHGDIB EMD TMPO PLEKHG3 ARHGEF16 ACVR1C RHOG VRK2 LEMD3 ACVR1B ARFGAP3 ACVR2B DEPDC1B CER1 NDUFS3 CDC42EP1 ELMO2 DOCK2 DOCK1 ARHGEF5 SALL4 RAB7A EPHA2 VAMP3 ARHGEF26 GARRE1 PPP1R12A SHMT2 PPP1R12B PLD1 PPP1R14A IQGAP2 KALRN ARHGAP21 LMAN1 STX5 YKT6 PTPRZ1 PAK4 NDUFA5 MCF2 MCAM ERBIN HSPE1 MPP7 KTN1 LETM1 VANGL1 ARHGAP32 DIAPH3 VAPB ESYT1 PPP1CB ABCD3 PPP1CA FABP5 FABP6 FABP7 PLIN3 PLIN1 MGLL ITGAV PTK2 EGR2 PFN1 PFN2 LEP FLRT3 PRKAR2A NRP1 CXCR4 SOX17 PAK6 PAK5 MYO9B ABL2 CXCL12 NCK2 NCK1 EVL SOS2 MMP2 RFNG POGLUT1 POFUT1 MFNG FLT4 MDK ACTA2 LINGO1 MAG OMG RTN4 NAB1 NAB2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 LYL1 F3 VGF ELK1 ASCL1 EREG CDK5R2 UHMK1 BTC EPGN HBEGF NGFR SQSTM1 CLTB DNM2 SOCS6 MTR ADRA2C ADRA2B ADRA2A KLB IRS1 PDE3B PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 MKNK1 FGF18 SPRY2 HGFAC TLR9 PIK3C3 FGFR4 FGF10 ITGA3 ITGA2 IL6R PDHB PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 RBCK1 PDHA1 PDGFRB TRAT1 NTRK3 PIK3AP1 PTPRU SH2B3 SH2B2 CMA1 FER TEC SH3RF1 FES GRAP LRRC41 NEDD4 RANBP10 KIF5B KIF5A CRHR2 RNF41 CUL5 INHBB SOCS1 MKRN1 UBE2M MTMR1 PIP5K1A PIP5K1B VHL EPOR ACVRL1 BMP10 BMPR2 AMHR2 FSTL1 CHRDL1 AMH NOG GDF2 SMAD9 SMAD5 GREM2 ZFYVE16 BMPR1B BMPR1A PTPRS PTPRF HGF FGFBP1 FGFBP2 FGFBP3 CTBP2 CTBP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 ARHGAP6 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 RAC3 GIT1 SWAP70 ARAP2 CYBB ARAP3 OCRL CYBA BCR AMIGO2 NOXO1 ARHGAP17 ARHGAP15 ABR RACGAP1 SLITRK3 TNFAIP1 NHS RND3 SLITRK5 NCKAP1L CKB WASF1 SEMA4F WASF2 CKAP4 IL32 NISCH KCTD13 GIT2 CDC14A ARHGAP26 BAIAP2 TAOK3 ABI2 NOXA1 ABI1 NOX3 NOX1 FERMT2 C1QBP DNMT1 PDGFRA PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B HES5 HEYL ELMO1 RHOU IL33 OPN1MW IL1RL1 PTK2B KLHL12 CYFIP2 WIPF1 HECW1 WIPF2 WDR91 ANKFY1 WIPF3 WDR81 GNAT3 C3AR1 CDC42SE2 ARHGAP9 ARHGAP8 OSBPL11 ADCY9 PRKAR1B LRRC1 ARHGAP4 BTK GMIP PRKAR2B CDC42EP5 CDC42EP4 PLCG2 CDC42EP3 ARPC1B CDC42EP2 ARPC1A FGD5 WASL CHN2 CHN1 SYK FARP1 GNAI3 DEF6 ADCY4 WDR11 VMA22 WAS SHKBP1 ADCY3 GOPC PRKX ADCY2 FILIP1 ADCY1 FAM13B ADCY8 FAM13A POTEE ADCY7 ADCY6 GOLGA8R GNAI1 RALGAPA1 ADCY5 FAM91A1 GNAI2 TEX2 ARMCX3 DDRGK1 NSFL1C ARHGAP11A ZNF512B CYSLTR1 ARHGAP11B TAGAP CYSLTR2 EFHD2 PLEKHG4 PLEKHG1 PLEKHG6 ARFGAP2 GNAZ BLTP3B NCKIPSD DVL1 SH3BP1 WHAMM DVL2 DVL3 GOLGA3 BAIAP2L2 SPATA13 ARPC4 TMEM87A ARPC5 FAF2 ARPC2 AKAP12 ARPC3 HINT2 SH3PXD2A RHOH ACTR3 RHOF ACTR2 RHOD RHOV PLEKHG4B ADORA2B EMC3 PRAG1 WASF3 SYDE2 ARHGAP44 DOCK11 ARHGAP40 BASP1 RALBP1 KCTD3 PREX2 ARHGAP45 TRIM27 ARHGAP19 ARHGAP18 USP13 TOR1AIP1 TNKS TNKS2 ARHGAP12 WWP2 ARHGAP22 RNF146 ARHGAP20 FRK RHPN1 OTUD3 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 IL2RG ARHGAP24 ARHGAP23 ARHGAP33 DIAPH2 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 RND2 ARAP1 GFOD1 PLCB4 ALS2 PEAK1 CCDC187 MOSPD2 FAM169A ADD3 FMNL1 FMNL2 GPNMB LRRK2 PRKCG GABRG3 GABRG2 LIN7B GNAL NBEA GABRB3 GABRB2 GABRB1 RASGRF2 RASGRF1 NRG1 ARHGEF9 CAMKK1 CAMKK2 GABRQ GABRA1 GABBR2 GABBR1 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 DUSP10 DUSP5 PSMD3 DUSP2 PSMD1 DUSP1 IKBKG BTRC PAQR3 DUSP8 MAP3K7 DUSP9 SKP1 PTPN3 CHUK PRKCB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PRICKLE1 PSMD11 PSMD14 PSMD13 PRKCI CUL1 RIPK2 PSMA7 MYD88 RELA RHO PSMB6 PSMB7 PSMB4 GNAT1 PSMB5 ATF1 UBB PSMB2 PSMB3 UBC PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 IRAK4 SEM1 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTPRA HDAC4 NR1H2 ARTN S100B NR3C1 GFRA3 SAA1 ESR1 GFRA2 GFRA4 AR RXRA NRTN ESRP1 RARA DOK1 PGR PPARG TRAK1 KAT5 PSPN CHEK1 IFT172 CCP110 CEP97 DYNC2H1 RPGRIP1L IFT88 MCHR1 KIF3A TTC21B NPHP4 IFT122 MKS1 PLK1 UBE2D1 IFT52 CDK1 IFT57 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 HGS OFD1 CTNNB1 EPS15 MET STAM2 IFT140 SH3GL2 SH3GL1 RALA SHC2 RALB SHC3 SHC1 YWHAB CRKL NRAS SSTR3 RAP1A WDR35 MAPK1 HRAS RALGDS MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK ATF2 WDR19 HDAC3 XPO1 PGRMC2 NRIP1 EP300 TBL1X MEF2D NCOA1 MED1 NCOA2 CREBBP MEF2C NCOR1 TBL1XR1 CARM1 PPP3CA PPP3CB RASGRP1 RASGRP3 PPP3R1 NFATC1 FKBP1A CALM1 YWHAE APP JUN FASLG CDC25C FOXO3 RHOBTB3 LMNB1 BCL2L11 CDK5 CDK5R1 RAB6A RAB9A RAB9B NOTCH1 RBX1 GLP1R UCN VIPR1 VIPR2 WNT2B SCT IHH ADM PTH1R FZD10 GNGT1 ADGRE1 CRHBP ADGRE2 SHH GNGT2 ADGRE5 UCN3 UCN2 ADGRE3 WNT5A GLP2R WNT9B PTH2R WNT9A WNT16 GIP ADCYAP1 SMO CRH IAPP ADCYAP1R1 RAMP2 CALCA RAMP3 CALCB CALCRL PTH GIPR DHH WNT8A WNT8B PTH2 PTHLH CRHR1 FLNA GHRHR WNT6 GNG10 GNG3 CALCR GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 WNT2 CD55 WNT3 WNT4 FZD1 STAT5A WNT10B STAT5B FZD3 WNT10A FZD2 GRB2 FZD5 FZD4 WNT3A PTCH1 FZD7 GCGR FOXA1 WNT7B KDM1A TLE3 FZD6 FKBP4 PTCH2 DDX5 FZD9 SCTR POU2F1 GREB1 FZD8 WNT7A CHD1 GCG CTSD NCOA3 GNG12 NR5A2 GNG11 GNG13 TFF3 ADM2 TFF1 GNB2 KANK1 CXXC5 GHRH GNB1 KDM4B GNAS PTGES3 GNB4 USF2 GNB3 USF1 GNB5 ZNF217 EBAG9 VIP RAMP1 SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 RASAL3 DAB2IP NF1 KBTBD7 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 CNTN1 NRP2 CDKN1A SPTAN1 CDKN1B CCND3 SPTB DNM1 DNM3 CCND1 E2F1 E2F3 NUMB TFDP1 NCAM1 RANBP9 TFDP2 CDK4 CCNE1 CDK2 SIRT6 FLT3 ELF3 ERCC6L NUP107 NOTCH2NLA ZWILCH NOTCH2NLC BUB1B NOTCH2NLB SMC3 FLRT2 CDC20 FLRT1 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RAD21 RCC2 NDC80 ZWINT STAG1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RUVBL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 OXTR AVPR1B AVPR2 OXT AVP AVPR1A DSP TJP1 CASP3 DSG1 DSG2 TJP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PDE1C GTF2F1 PDE1B GTF2F2 PDE1A GRK2 PRKCD PLA2G4A H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 AKT1 PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B TRIB3 EPAS1 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 HIF1A PIK3R6 FSTL3 PIK3R5 GRB10 INSR LYN WWTR1 YES1 NOTUM H4C9 TRRAP JUND SOX3 FRAT1 MOV10 FRAT2 AGO3 STAT6 SOX6 AGO4 SOX7 H2AC20 SOX4 AGO1 RNF43 AGO2 CTNNBIP1 CD28 SOX13 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TLR1 TAB3 TAB2 TAB1 TLR6 IRAK1 TLR2 PPP2R5D MEF2C TRAF2 PELI1 IKBKB TLR4 TRAF6 IKBKG BTRC MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 ATF1 UBB CD14 ECSIT NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 IRAK4 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 PELI3 S100A9 NFKBIB PELI2 S100A8 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 SIGIRR BTK S100A1 CD36 IRAK3 TIRAP TP53 TIFA ALPK1 SOCS1 FGB FGA RPS6KA3 RPS6KA2 FGG MAP2K3 MAP2K4 MAP2K7 MAP2K6 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures LAMB3 COL9A2 COL6A5 LAMA3 LAMC2 MMP9 LOX COL1A1 LOXL3 COL1A2 LOXL4 PLEC LOXL1 LOXL2 MMP20 CTSV CTSL CD151 MMP13 MMP7 COL18A1 CTSS PXDN COL15A1 CTSB COL11A1 COL11A2 PCOLCE COL10A1 COL27A1 COL24A1 MMP3 COL3A1 COL2A1 COL4A2 ITGB4 COL5A1 COL4A1 COL7A1 COL6A2 BMP1 COL5A3 TLL2 COL4A4 TLL1 COL5A2 COL6A1 ITGA6 COL4A3 COL9A1 COL8A2 COL6A3 COL8A1 COL4A5 COL9A3 COL6A6 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN TNKS2 AXIN2 RNF146 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 AXIN1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMURF2 TNKS POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ10 KCNJ16 KCNJ1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases IFIH1 RNF135 TRIM25 OTUD3 VCP TNIP1 TNIP3 MAVS UBA52 YOD1 TP53 UBE2D1 RNF128 RIGI ZRANB1 RIPK2 CDK1 PTEN TRAF3 UBB RHOA UBC RPS27A OTUD7A TRIM4 NOD1 NOD2 APC OTUD5 TNFAIP3 VCPIP1 OTUD7B TNIP2 ESR1 TRAF6 RIPK1 IKBKG OTUB1 OTUB2 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation ITGA2B SERPINA1 ALDOA SOD1 FN1 F5 F8 PSAP CD9 EGF CLU SERPING1 TF VEGFA PPBP HGF TGFB1 APOA1 LAMP2 PCDH7 PPIA CALM1 APP SERPINE1 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 CD109 TAGLN2 NHLRC2 TEX264 STXBP2 PDGFB ENDOD1 A1BG APOH VTI1B RAB27B MANF PROS1 A2M APOOL CALU MAGED2 HRG FERMT3 SERPINA3 HSPA5 ORM1 ECM1 OLA1 CTSW ORM2 SERPINA4 TMSB4X TIMP3 GAS6 ALB QSOX1 AHSG ANXA5 TOR4A CD63 SPP2 LEFTY2 LY6G6F VEGFB VEGFC VEGFD TIMP1 LHFPL2 PCYOX1L TGFB2 F13A1 BRPF3 POTEKP TUBA4A CD36 CFL1 FAM3C ABCC4 APLP2 TMX3 SELENOP SCG3 RARRES2 PFN1 CYRIB SELP FLNA SCCPDH ACTN2 LGALS3BP WDR1 PLEK PHACTR2 CYB5R1 SRGN KNG1 MMRN1 PECAM1 CAP1 ITIH4 IGF2 ITIH3 THBS1 IGF1 PLG TTN TGFB3 CLEC3B CDC37L1 CFD ITGB3 ACTN1 FGB FGA VWF FGG TLN1 VCL PF4 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency OTC OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling PPP2CA PPP2CB CALM1 PRKACG PPP1R1B PRKACB CDK5 PDE4A PLCB4 PDE4D PDE4C GNGT1 PPP1CA POMC MAPK1 GNGT2 GNAT3 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B PPP2R1B PRKAR2B PPP2R1A PRKACA PDE1C PDE1B PDE1A GNAI3 GNAL ADCY4 GRK2 PRKCD PRKCA NBEA PLA2G4A PLCB3 ADCY3 PLCB1 PRKX PLCB2 ADCY2 OPRM1 CAMK2B ADCY1 CAMK2D ADCY8 GNAQ CAMK2A ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 GNG7 PRKAR1A GNG8 CAMK4 CAMK2G CAMKK1 CAMKK2 PPP3CC PPP2R5D GNA14 GNA15 GNA11 GNG12 GNG11 GNG13 GNB2 GNB1 PPP3CA PPP3CB PDYN GNB4 GNB3 GNB5 PPP3R1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification GNAI3 GNA13 PLA2G4A TBXA2R GNAQ GNG10 GNG3 GNAI1 GNG2 GNAI2 GNG5 P2RY12 GNG4 GNG7 GNG8 AAMP GNA14 GNGT1 GNA15 GNA11 P2RY1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNAT3 MAPK14 GNB4 GNB3 GNB5 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation UBE2O TPP2 BLMH UBA1 UBE2K UBE2M TRIM71 ANAPC7 RNF14 UBE2C KBTBD13 UFL1 UBE2E1 UBE2Q1 UBE2D1 UBE2Q2 ANAPC10 TRIM69 ANAPC11 UNKL DTX3L CDC23 PJA2 UBE2S PJA1 SEC22B CDC26 TRAF7 CDC27 HLA-A UBE2R2 ERAP2 B2M CDC16 THOP1 ERAP1 TRIM50 ANAPC4 MGRN1 ANAPC5 ASB13 ANAPC1 ASB14 ANAPC2 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 SEC31A RCHY1 PSME1 ASB18 PSME2 FBXL22 ASB15 FBXL21P ASB16 PSMB10 FBXL20 ZNRF1 ZNRF2 PSMB8 HECTD1 PSMB9 HECTD2 HECTD3 ASB10 VHL TRIM41 UBE2D2 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 MIB2 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 CTSV ASB7 TRIM36 CTSL TRIM37 ASB4 ASB5 ASB2 TRIM32 CDC34 ASB3 ASB1 UBE2V1 LY96 NCF1 UBE2N NCF2 NCF4 SNAP23 CYBB CYBA TLR4 FCGR1BP VAMP3 ELOB BECN1 ELOC MYLIP RNF111 RBX1 NEDD4L S100A9 S100A8 FBXO4 FBXO6 FBXW4 BTK FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 ITGAV FBXL3 FBXL5 CUL2 RBBP6 WWP1 FCGR1A CUL3 KBTBD7 ATG14 ITGB5 FZR1 SKP2 SEC23A SAR1B CDC20 VAMP8 SEC24B SEC24A SEC24D SEC24C HLA-H HLA-C HLA-F PIK3R4 HLA-G HLA-E HMGB1 UBE2L3 TLR1 CALR TLR6 TLR2 SEC13 PIK3C3 PDIA3 RNF34 UBE2D3 PSMD8 IKBKB CANX PSMD6 PSMD7 PSMD2 PRKN PSMD3 PSMD1 LRR1 IKBKG CCNF BTRC KEAP1 CBLB SKP1 UBE2L6 CHUK HERC5 DCAF1 FBXW11 HERC4 PSMA5 HERC3 PSMA6 ITCH RNF115 PSMA3 HERC2 PSMA4 RNF114 PSMA1 HERC1 PSMA2 TRIM21 UBA52 FBXO7 STUB1 HERC6 PSMD12 FBXO9 PSMD11 WSB1 PSMD14 FBXO2 PSMD13 RNF123 CUL1 HLA-B RNF126 HECW2 PSMA7 MYD88 RBCK1 CBLL2 TRIM11 PSMB6 ANAPC13 PSMB7 UBE2J2 PSMB4 UBE2J1 PSMB5 RNF213 CD14 UBB RNF217 PSMB2 ATG7 PSMB3 HACE1 UBC SIAH2 PSMB1 SIAH1 RPS27A LNPEP ADRM1 MEX3C UBAC1 SEM1 FBXL8 FBXL4 PSMC5 DZIP3 PSMC6 FBXL7 PSMC3 RNF220 PSMC4 DET1 PSMC1 LRSAM1 PSMC2 SH3RF1 TRIM9 MRC1 TRIM4 TAP2 ARIH2 TAP1 SOCS3 CD207 LRRC41 HSPA5 RNF144B SEC61A2 MRC2 GAN RNF138 SEC61A1 SEC61G RNF130 SEC61B HUWE1 KCTD6 KLHL2 TAPBP STX4 UBE2G1 KLHL3 UBE2B UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 RLIM TRIP12 SMURF2 KBTBD8 SPSB4 SMURF1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 S100A1 CD36 RNF19B UBE3A FBXO32 UBE3B TIRAP FBXO21 UBE2Z FBXO22 NPEPPS RNF19A FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 UBE2E2 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 CTSS TRAIP RNF41 KLHL42 UBE2V2 CUL7 TRIM63 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F FGB UBE2H FGA KLHL25 ZBTB16 GLMN FGG KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U MKRN1 RNF182 UBA3 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen FGG FGB FGA ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors GRIA1 GRIA3 GRIA4 GRIA2 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation PPP2CA PPP2CB PPP2R1B PPP2R1A THEM4 CTLA4 RAC1 MAP3K14 PRR5 AKT2 VAV1 PIK3CD AKT3 PIK3CB AKT1 PIK3CG MLST8 PPP2R5E TRIB3 PAK1 PDPK1 MAPKAP1 RICTOR PIK3R3 PAK3 PIK3R2 PAK2 PPP2R5B PIK3R1 PPP2R5A PIK3CA PPP2R5D PIK3R6 PPP2R5C LCK PIK3R5 LYN CDC42 YES1 CD86 FYN CD80 GRAP2 MAP3K8 MTOR CD28 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation RPS2 EIF2S3 EIF2S2 EIF2S1 FAU EIF4E EIF4B RPS27A EIF4G1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 PABPC1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes CSNK2B CDK1 CCNB2 NCAPD2 SMC4 SMC2 NCAPG NCAPH CCNB1 CSNK2A1 CSNK2A2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking NOS3 NOSIP ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNAI3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 GNAT3 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 ADCY9 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes H2AX ASH2L CCNC PPARGC1B H3-3B H3C8 H2AJ H3C15 MED16 RB1 MED17 MED12 MED14 MED13 H2BC9 H2BC8 MED10 H2BC5 ABL1 AGPAT2 H2BC3 H2BC1 MED27 H2AB1 MED23 H2AC8 H2AC6 MED24 H2AC7 MED20 CDK8 KMT2C GPAM SCD ADIPOQ HDAC3 PHLDA1 ACSL1 PEX11A DPY30 H2BC26 H2BC21 CIDEC WDR5 EP300 TBL1X H2BC17 H2BC12 PPARGC1A ELOVL5 H2BC13 NCOA1 H2BC14 MED1 H2BC15 PLIN4 NCOA2 CREBBP NCOA6 THRSP H2BC11 PNPLA2 SIRT1 NCOR1 TBL1XR1 PLIN2 RBBP5 CEBPA H2AZ2 PDK4 ACSS3 CDK5 ANGPTL4 MED4 MED6 MED7 KMT2D LPL LIPE DGAT2 MED30 MED31 KDM6A FABP4 PLIN1 LPIN1 RXRA MGLL CD36 NCOR2 H2AC19 H2AC14 H2BC12L PAXIP1 GPS2 PAGR1 NCOA3 H4C9 NR5A2 AJUBA H2AC20 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 ELMO2 DOCK1 RASA1 UBA52 RAC1 SFPQ ARAP1 UBB UBC RPS27A CBL ELMO1 GPNMB LRRK2 PTK6 CDKN1B EREG BTC SOCS3 CCND1 HBEGF NRAS STAT3 HRAS NR3C1 EGF CDK4 CCNE1 CDK2 DOK1 CRK NRG2 NRG3 NRG4 EGFR PXN RHOA AKT1 ERBB2 NRG1 BCAR1 EPAS1 SRMS KHDRBS1 HIF1A KHDRBS2 KHDRBS3 STAP2 ARHGAP35 PELP1 PTPN1 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase KPNA1 H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 LMNB1 CASP7 DBNL GAS2 MAPT ADD1 PLEC CDH1 CTNNB1 SPTAN1 BMX PAK2 DSP APC TJP1 OCLN CASP3 DSG1 PKP1 SATB1 DSG2 DSG3 TJP2 CLSPN GSN PRKCQ PTK2 PRKCD CASP6 STK24 STK26 DNM1L ACIN1 KPNB1 ROCK1 HMGB1 CASP8 DFFB DFFA HMGB2 VIM BIRC2 BCAP31 FNTA FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGB1 FN1 CEACAM1 ITGA5 CEACAM6 CEACAM8 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CHEK2 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK3 MAPK14 MAPK11 CHEK1 CSNK1E CSNK1A1 NEK11 GSK3B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System SERPINA1 H2AX CTSC GNLY CD3G MAGT1 LPO HSPA6 DCD F12 RNASE6 RAC1 KLKB1 RNASE8 RNASE7 H3-3B BPIFA1 BPIFA2 H3C8 FOS BPIFB1 BPIFB4 TCIRG1 BPIFB6 VAV1 FTH1 ATP6V1E1 ATP6V1E2 CD59 ATP6V0B ATP6V1G1 EPPIN ATP6V0E1 ATP6V1G2 CHGA H3C15 KIR2DS4 PAK1 KIR2DS5 TRAPPC1 NOS3 ATP6V1B2 ATP6V0D1 ATP6V0C PAK3 S100A7A ATP6V0D2 FTL PAK2 ITLN1 SIGLEC16 ATP6V1B1 SIGLEC15 H2BC9 ATP6V1A KLRC2 H2BC8 HTN1 H2BC5 HTN3 CAND1 H2BC3 ATP6V0A2 ATP6V1H ACTR1B H2BC1 ATP6V0A4 CTSH ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HMOX2 ATP6V1F ATP6V1C2 ATP6V0A1 H2AB1 GRAP2 MAP3K8 LCN2 H2AC8 H2AC6 H2AC7 ZBP1 TBK1 IRF3 VCP NLRP4 DTX4 PRKCE NFKB2 MAP3K14 STK10 PIK3CB H2BC26 H2BC21 PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA LCK STOM H2BC11 JUP CDC42 FYN DIAPH1 PTPN11 CD4 PTPN6 FCER1G AP2A2 GPR84 PRKACG PRKACB TNFRSF1B NPC2 ACAA1 SLC27A2 BIN2 A1BG A2M HRG SERPINA3 ORM1 ORM2 ACTB QSOX1 AHSG IDH1 CD63 CFL1 TP53 NF2 GNS PECAM1 CCT2 AAMP DERA CDA PYGB PYGL MANBA CCT8 GAA PGAM1 TUBB4B ALDOC ALDOA CD44 DBNL AGL PANX1 GYG1 TKFC GSN MAN2B1 HPSE B4GALT1 KPNB1 HK3 PGM2 TAX1BP1 PGM1 CASP9 ISG15 DEFB103B DEFB105B DEFB129 DEFB128 DEFB131A DEFB127 DEFB126 DEFB125 DEFB124 DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B HSP90AA1 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DNAJC3 DEFB115 DEFB136 DEFB114 DEFB113 DEFB135 DEFB112 DEFB134 DEFB133 DEFB110 DEFB132 DEFB108B DEFB108C DEFB130A DEFB130B DEFB4B GALNS PFKL HSPA1A HLA-B LIMK1 TICAM2 TICAM1 TANK TRAF3 CD14 IKBKE OPTN VNN1 EEA1 PDZD11 TASL RBSN IRF5 PROS1 CD33 SLC15A4 CD300A TNFAIP3 AMPD3 APRT CYLD PNP CD177 RAB27A ATP8A1 CLEC10A CLEC4A CLEC4C CLEC4D ATP11B CLEC4E ATP11A CLEC7A CLEC6A CARD9 PLPP5 PLPP4 PLD3 TRPM2 MIF CNN2 ATP8B4 ATP7A CYB5R3 ANO6 VTN B2M AP1M1 APEH LPCAT1 UBE2D2 IGHV3-23 IGLV AGPAT2 IGLV2-8 IGKV1-16 IGKV1-17 PLD2 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 P2RX1 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 DSC1 CDC34 PLA2G2A IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 RASGRP4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 PLAC8 IGLV1-44 PI3 IGKV3-15 IGKV3-11 V2-8 V1-20 CEACAM1 IGKV2D-40 RHOA IGHV3-11 IGHV3-13 IGKV1D-16 ASAH1 ICAM2 IGLV7-43 IGKV1D-12 ICAM3 RELB IGLV1-51 IGLV2-23 RPS6KA5 CD209 UBE2N TAB3 TAB2 TAB1 IGKV3-20 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 RAB10 V1-7 RAB14 STBD1 V5-1 LAMP2 V1-5 V1-3 IGKV3D-20 V5-6 TRAF6 IGHE IGLV3-19 RHOG IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 ELMO2 IGKC DOCK2 IGLV3-21 DOCK1 IGKV1-39 IGKV1-33 RAB7A V4-6 IGHV3-53 V4-2 IGLC7 V4-1 PLD1 IGKV5-2 IQGAP2 IGKV1-5 IGLC6 PRTN3 VAPA RPS6KA1 AOC1 ATG12 ATG5 RAC2 S100A9 S100A8 DGAT1 FUCA1 FABP5 ITGAM ITGB2 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 ITGAX IFIH1 RNF135 TRIM25 IFNA21 CD47 IFNA14 IFNA16 VAV3 IFNA17 ITGAV ANXA2 SIKE1 PTK2 MAVS IFNA10 RIGI NME2 VAV2 RAB5B IMPDH1 RAB5C IMPDH2 CAP1 FCGR3B HSP90AB1 ROCK1 MYO9B ACTG1 BST1 NCK1 OTUD5 KCNAB2 NEU1 CAB39 CTSA LAMTOR2 LAMTOR1 LAMTOR3 RAB3D RAB44 SNAP25 ELK1 RAB37 RAB4B CTSZ COMMD9 COMMD3 TXNDC5 RAB24 HSPA8 DNM2 VAMP8 MLEC MUC12 MUC13 MUC15 PIK3R4 MUCL1 MUC3A MUC5AC MUC3B HMGB1 CFP CASP8 CASP5 CASP4 GAB2 CASP1 TLR9 PIK3C3 MUC1 RIPK3 IL18 TRAF2 MUC2 COPB1 IL1B PELI1 MUC7 MUC4 MUC6 MUC16 MUC17 BIRC2 MUC19 BIRC3 PLAUR MUC5B MUC20 MUC21 SDCBP RIPK1 FADD ELANE UBE2L6 GSDMD MGST1 HERC5 ITCH TRIM21 GSDME FPR2 CPNE1 ARMC8 CPNE3 ATG7 TEC TRIM4 HUWE1 CST3 TTR H2AZ1 F2 LYZ SNAP29 PTAFR TSPAN14 AHCYL1 SEMG1 ART1 DEFA1B PRSS3 NOS1 PRSS2 PRKACA DEFA6 DEFA4 ADA2 DEFA5 DEFA3 HP ANPEP MME ITPR1 ATP6AP2 ITPR2 KNG1 ITPR3 UBA7 UBR4 CD180 LY86 LBP BPI SURF4 SOCS1 RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 ITK LCP2 TXN LAT2 MAP2K7 MAP2K6 UBA3 UBE2K UBE2M ARSA MAPK9 MAPK8 MAPK7 IFNB1 MAPK10 TCN1 PLCG1 BCL2 CD81 C4BPA C4BPB BCL2L1 CLU SERPING1 CPB2 EEF1A1 CFH TRIM32 C5AR2 C5AR1 EEF2 CFI C6 C7 C9 ADAM10 CD19 C8B C8A C8G CR2 CHRNB4 CD46 CPN2 CPN1 CFHR2 NAPRT CFHR1 CFHR4 CFHR3 CFHR5 PDXK NCKAP1 ALOX5 NCF1 NCF2 NCF4 C3 SNAP23 C4A BRK1 C5 C4B_2 CFB C2 SERPINB6 PLAU MGAM CYBB CYBA TXK CHIT1 NCKAP1L WASF1 WASF2 CKAP4 BAIAP2 ABI2 ABI1 TOLLIP C1QBP SLC2A5 PSEN1 NCSTN HCK MMP25 ELMO1 CEACAM6 CEACAM8 PRKCSH CYFIP2 WIPF1 NOS2 WIPF2 WIPF3 ADAM8 C3AR1 ARHGAP9 BTK MEFV GOLGA7 PLCG2 MYO5A MMP8 ARPC1B ARPC1A WASL CTSG SYK WAS PYCARD LRRC7 IGHG3 IGHG4 IGHG1 IGHG2 OLR1 MYH9 TIFA CEACAM3 ALPK1 NCKIPSD CD58 NLRP3 ARPC4 SIRPA ARPC5 FAF2 ARPC2 PCBP2 ARPC3 PSTPIP1 FCGR3A BST2 SELL ACTR3 CALM3 RHOF ACTR2 TREM1 CALM2 FGR MYH2 FCGR1A WASF3 MYO10 P2RX7 TXNIP FCGR2A MYO1C SUGT1 ARHGAP45 PPIE FRK DDX3X SIRPB1 DYNLT1 PLD4 MMP9 KLRK1 KIR2DS2 MOSPD2 SIGLEC9 NCR2 HVCN1 GDI2 LILRA3 CASP10 HSPA1B LAIR1 CLEC5A RAB31 LILRB2 LILRB3 SIGLEC5 OSCAR CD300E RAB18 CD300LB HLA-H HLA-C KLRD1 HLA-E TOMM70 TLR1 TLR6 TLR2 UBE2D3 PSMD8 IKBKB LTF PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ALAD UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 BCL10 PSMA7 MYD88 RELA MALT1 PSMB6 PSMB7 ACTR10 PSMB4 PAFAH1B2 PSMB5 ATF1 UBB ECSIT PSMB2 PSMB3 NKIRAS1 NKIRAS2 UBC IKBIP PSMB1 MEF2A RPS27A DUSP4 ADRM1 DUSP3 NFKB1 IRAK4 SEM1 VRK3 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 TLR10 PSMC3 PSMC4 TLR5 LRRC14 PSMC1 PSMC2 USP14 NLRX1 PTPRC PELI3 PELI2 NFKBIB TREM2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 MAP3K1 S100B TNIP2 SAA1 NDUFC2 SIGIRR TYROBP S100A1 CD36 IRAK3 MRE11 TIRAP PIN1 ITGAL SRP14 APAF1 PRDX6 GSTP1 SLCO4C1 ATOX1 PTPN4 UBE2D1 LGALS3 CEP290 CTNNB1 TUBB SLC11A1 NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 CTSV MAPK14 CTSL CTSK MAPK12 MAPK13 MAPK11 PKM MAPKAPK3 MAPKAPK2 SOS1 CRK ARG1 ATF2 FCER1A MS4A2 LY96 HBB CRCP HMOX1 EP300 NLRP1 APOB IRAK1 POLR3GL POLR3A POLR3B POLR3C CREBBP POLR3D MEF2C POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H ILF2 POLR3K TLR4 PPP3CA PPP3CB PPIA RASGRP1 CAT PPP3R1 NFATC3 RETN NFATC2 NFATC1 CALM1 APP JUN HGSNAT CAPN1 RAB6A IST1 IGF2R SLC44A2 RAB9B DHX58 RNF125 TBC1D10C RNF216 FRMPD3 GMFG ADGRE5 ABCA13 PGLYRP1 NHLRC3 MCEMP1 ADGRE3 RNASE3 CDK13 SCAMP1 RNASE2 UNC13D FLG2 PADI2 GPI CRACR2A PRDX4 S100A11 AZU1 PLA2G6 PA2G4 HRNR PIGR SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 PLEKHO2 SERPINB10 GRN SERPINB12 AGA ERP44 LRG1 YPEL5 GHDC TMEM179B EPX LAMP1 TOM1 KCMF1 OLFM4 ARL8A S100A7 BRI3 PTPRB NIT2 CD55 FCAR GM2A ACP3 RNASET2 TMBIM1 CANT1 FGL2 PRCP CPPED1 MNDA FOLR3 VPS35L CALML5 C6orf120 KRT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 VAT1 CTSD PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 CYSTM1 PTPRJ GLIPR1 CAMP CD53 FPR1 RAP2C RAP2B DNASE1L1 CSTB PGRMC1 CREG1 ORMDL3 GCA PTGES2 SVIP QPCT CD68 MPO COTL1 ENPP4 OSTF1 CD93 IRAG2 ATAD3B DOK3 ADGRG3 HEXB DPP7 ALDH3B1 GGH DNAJC13 TARM1 DEGS1 MS4A3 TNFAIP6 CRISP3 HEBP2 CHI3L1 GLB1 CLEC12A MVP TMEM30A CMTM6 PDAP1 S100P PTX3 GUSB ARSB GLA SPTAN1 PSAP DNM1 DNM3 ABL1 NFASC PPP2R1B PPP2R1A DYNC1LI1 PPBP DSN1 CCR6 RAB3A CCR2 CR1 CXCR1 PPP2R5D DYNLL1 DNAJC5 CXCR2 NLRC4 PPP2CA PPP2CB CXCL1 DYNC1H1 DSP CASP3 DSG1 ACLY PKP1 POLR2E POLR2F CAPZA1 POLR2H CAPZA2 TIMP2 POLR2K POLR2L SLC2A3 PRKCD CASP2 H2AC19 H2AC14 H2BC12L UNC93B1 TLR8 TLR7 FUCA2 TLR3 BPIFB2 CTSS LGMN CTSB HSP90B1 FCN1 FCN2 FCN3 CSNK2B MASP1 CFD MBL2 CRP C1QB C1QA COLEC11 COLEC10 IQGAP1 C1S PIK3R2 C1R PIK3R1 RAP1B GZMM C1QC FGB CGAS FGA LYN DDX41 PGLYRP4 LRRFIP1 PGLYRP3 FGG AIM2 PGLYRP2 YES1 IRF7 TRIM56 H4C9 PRKDC DHX9 RAF1 NLRC3 REG3A IFI16 REG3G DHX36 VCL STAT6 XRCC6 LTA4H KIR3DS1 XRCC5 H2AC20 LEAP2 TREX1 STING1 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair PCNA LIG1 POLD3 POLD4 POLD1 POLD2 POLB POLE APEX1 RFC5 RFC3 RPA1 RPA2 RFC4 RFC1 POLE4 RFC2 RPA3 POLE2 POLE3 FEN1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition FBXW11 AURKA CEP57 CLASP1 YWHAE CETN2 CEP164 PPP1R12A UBA52 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CCNB1 CUL1 CNTRL CDK1 UBB CEP290 NINL OPTN UBC RPS27A RAB8A OFD1 CPAP PPP1CB TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 BORA HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 CCNB2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 AJUBA ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 BTRC SKP1 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors GP5 F11 GP1BA F9 KNG1 F12 GP9 KLKB1 GP1BB DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation PRIM1 POLA1 POLA2 POLE POLE4 POLE2 PRIM2 POLE3 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism ALDOB GALNS G6PC3 RPIA G6PC1 UBA52 TALDO1 PPP1R3C NHLRC1 IDUA SGSH HGSNAT GNS UBB SLC37A4 UBC GLB1 NAGLU HYAL1 RPS27A DCXR GYG2 IDS GYG1 GUSB EPM2A ARSB GBE1 KHK GYS2 GYS1 GAA SI LCT FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions GJA1 DNM2 CLTB DAB2 CLTCL1 CLTC DNM1 CLTA AP2M1 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT4 VEGFD KDR PGF VEGFB FLT1 VEGFC VEGFA ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase EP300 HSF1 CREBBP FKBP4 HSPA1A HSP90AA1 HSPA1B HSPA1L HSBP1 PTGES3 HSPA2 HSP90AB1 HSPA8 DNAJB1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase POM121C NUP42 NUP62 TPR H2AX BANF1 NUP88 RAE1 NUP214 PLK1 NDC1 NUP210 NUP155 NUP153 NUP93 CCNB1 GORASP1 NUP50 NUP35 NUP54 H3-3B ARPP19 RAB1A NCAPH2 CDK1 NCAPG2 H3C8 ENSA RAB1B NCAPD3 RAB2A H2AJ USO1 CTDNEP1 BLZF1 CNEP1R1 NEK9 MASTL NEK6 GORASP2 NEK7 MCPH1 PPP2R2D H3C15 RB1 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 MAPK1 H2BC1 SET H2AB1 NUP107 H2AC8 H2AC6 H2AC7 PPP2R1B PPP2R1A NUP160 CCNB2 NUP85 H2BC26 H2BC21 H2BC17 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 H2BC11 EMD H2AZ2 LEMD3 KMT5A PPP2CA PRKCB PPP2CB NUP43 RANBP2 LMNB1 GOLGA2 SMC4 SMC2 NUP37 VRK1 LEMD2 NUMA1 LPIN1 LPIN2 LPIN3 PRKCA H2AC19 H2AC14 H2BC12L H4C9 NUP205 POM121 H2AC20 NUP188 AAAS SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 XPO1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 PTTG1 SMC1A RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 PSMD8 KIF2C KIF2B PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CLASP1 PSMA4 DYNC1I1 PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 PSMD12 CENPU PSMD11 NDE1 PSMD14 CENPE PSMD13 CENPF CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO UBB CENPP PSMB2 CENPQ PSMB3 SPC24 UBC MAD2L1 PSMB1 CENPS RPS27A NUP37 ADRM1 SPC25 SEM1 ESPL1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions SDC1 ITGB1 ITGB3 TRAPPC4 ITGAV VTN ACTN1 PRKCA ITGB4 ITGA2 SDC4 SDC2 SDC3 ITGA6 TGFB1 THBS1 TNC FGF2 CASK ITGB5 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression EIF4E EIF4B EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 CYP11B1 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFB2 TGFBR1 TGFBR2 TGFBR3 ARRB1 TGFB1 GIPC1 ARRB2 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis F11 GP1BA PROS1 F5 F8 ADAMTS13 F10 GP9 FGB GP1BB FGA GP5 GGCX VWF FGG TPST2 TPST1 F2 F9 PROC ANO6 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA DBT BCKDHB DLD SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 THEM4 IGF1R KLB IRS1 PDE3B AKT2 PIK3R4 IRS4 IRS2 IGF2 CILP FGF1 IGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins FURIN GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 SOS1 FGF18 FGF10 NRAS HRAS FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol CYP8B1 CYP46A1 CYP39A1 AKR1C3 HSD3B7 SLC27A5 AKR1C1 AKR1D1 AKR1C2 AKR1C4 CYP27A1 AMACR SLC27A2 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle PPFIA3 PPFIA2 SNAP25 SYT1 UNC13B CHAT VAMP2 CPLX1 STX1A TSPOAP1 SLC18A3 SLC5A7 RAB3A RIMS1 PPFIA1 PPFIA4 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins AQP10 AQP6 AQP4 AQP5 AQP12A AQP2 AQP3 AQP11 MIP AQP9 AQP7 AQP1 AQP8 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex FURIN FKBP1A CCNK TGFBR1 UBE2M CCNT2 TGFBR2 TRIM33 CCNT1 CCNC UBA52 STUB1 UBE2D1 MEN1 SERPINE1 PPM1A JUNB RNF111 COL1A2 UBB UBC RPS27A ITGB5 CBL NEDD4L CDK9 PPP1CB CDKN2B HDAC1 NEDD8 ATP1B4 PPP1CA MAPK1 TFDP1 MAPK3 SNW1 TFDP2 SKIL SMAD2 SMAD4 SMAD3 SMURF2 SMURF1 PPP1CC SMAD7 TGFB2 CDK8 ITGAV TGFBR3 STRAP YBX1 NCOR2 SP1 PPP1R15A USP15 RBL1 LTBP4 ARHGEF18 LTBP2 LTBP3 CGN F11R MTMR4 MYC PRKCZ LTBP1 ITGB8 RHOA TGFB1 PMEPA1 PARD6A ITGB6 PARD3 TGFB3 XPO1 UCHL5 USP9X BAMBI ITGA8 EP300 SKI ITGB1 ITGB3 E2F4 PARP1 WWTR1 NCOR1 E2F5 UBE2D3 TGIF1 TGIF2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) BTK TLR1 S100A1 TLR6 CD36 TLR2 TIRAP S100A9 S100A8 FGB FGA MYD88 FGG TLR4 LY96 CD14 HMGB1 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 JAG2 JAG1 ADAM10 DLL1 DLL4 ADAM17 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism GUSB CD44 SPAM1 STAB2 ABCC5 HAS1 CEMIP HYAL2 HAS3 SLC9A1 SLC17A5 HMMR HEXB HAS2 HEXA LYVE1 HYAL1 HYAL3 CHP1 HYAL4 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1L1 UBIAD1 VKORC1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K GAB1 NTF4 PIK3CA PIK3R1 NTRK2 BDNF GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 CCNB1 GORASP1 GOLGA2 MAPK1 RAB1A CDK1 CCNB2 RAB1B RAB2A USO1 BLZF1 GORASP2 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CDK6 CDK4 CCND3 CCND2 CCND1 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA2D2 GNG10 ADRA2C ADCY6 GNG3 GNAI1 ADRA2A ADCY5 GNG2 GNAI2 CACNA1C GNG5 GNG4 GNG7 GNG8 CACNB2 CACNB3 GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 CACNA1D GNB1 GNB4 GNB3 GNB5 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNA6 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis GSK3A DUSP16 HGS RAB7A KPNA1 CTSG UBA52 SFPQ MAPK1 ATP6V1H RAB5A KPNB1 MAPK3 VPS33B NOS2 PGK1 CORO1A RNF213 UBB UBC ENO1 TRIM27 RPS27A VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V1H ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1C1 ATP6V1E1 ATP6V1A ASAH1 ATP6V0B ATP6V1G1 ATP6V0E1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse ARHGEF12 MYH9 RHOB RHOC MYL12B MYH11 SEMA4D LIMK2 RND1 LIMK1 MYH14 MYH10 PLXNB1 MYL6 RHOA ERBB2 ROCK1 MYL9 ROCK2 ARHGEF11 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants STAT5A STAT5B GAB2 ZMYM2 PIK3R1 PIK3CA STAT1 STAT3 LRRFIP1 BCR CUX1 FGFR1OP2 MYO18A CPSF6 TRIM24 CEP43 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs JAK1 MAPK1 MAPK3 IFNG RAF1 IFNGR1 JAK2 IFNGR2 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis RIPPLY2 DLL3 PSMA5 PSMA6 PSMA3 DLL1 LFNG PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 TBX6 SEM1 NOTCH1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RBPJ PSMC2 LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 EPHA4 PSMD1 HES7 MESP2 MSGN1 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK PCNA UBA52 POLK RFC5 RFC3 RPA1 RPA2 RFC4 UBB RFC1 REV3L RFC2 UBC RPA3 RPS27A REV1 MAD2L2 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events STRA6 RDH12 OPN1LW LRAT RLBP1 OPN1MW TTR NAPEPLD ABCA4 RBP4 RDH5 OPN1SW RBP1 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets PPP2CA RPS6KA5 VRK3 PPP2CB DUSP6 PPP2R1B DUSP7 MAPK7 PPP2R1A ELK1 PPP2R5D MEF2C RPS6KA3 RPS6KA2 MAPK1 RPS6KA1 MAPK3 MAPK14 MEF2A DUSP4 DUSP3 MAPK11 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation CD3G RAC1 VAV1 PAK1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 HSP90AA1 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 LIMK1 ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B CFL1 ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 NF2 IGHG3 IGHG4 IGHG1 HSP90AB1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 ACTR2 MYH2 FCGR1A WASF3 MYO10 FCGR2A MYO1C METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors MCCC2 MCCC1 GSTO2 DHFR2 PRSS1 NADSYN1 FLAD1 CTRB2 CTRB1 SLC5A8 BTD MTHFD1 MTHFD2 MTHFD2L SHMT1 HLCS SLC19A3 PNPO SLC19A1 SLC19A2 CBLIF MTHFR MTHFS TCN1 CD320 MOCS2 MOCS3 QPRT THTPA SLC22A13 NMRK2 RFK NMRK1 CD38 MTHFD1L RNLS TPK1 MOCOS ACACB NMNAT3 ACACA NMNAT2 NMNAT1 ALDH1L1 ALDH1L2 NUDT12 SLC25A51 NNMT FOLR2 MTRR NADK SLC52A2 SLC52A3 GSTO1 SLC52A1 MTR GPHN ABCD4 NADK2 NAPRT ACP5 SLC2A1 AOX1 SLC46A1 SLC25A19 LMBRD1 PDXK NAXE SLC25A32 NAXD LRP2 TCN2 PC SHMT2 LDLRAP1 NAMPT CUBN AMN PANK4 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 SLC5A6 VNN1 NUDT8 VNN2 PDZD11 PPCS FASN ENPP2 ENPP1 ENPP3 SLC25A42 AASDHPPT ABCC1 PARP6 PARP4 PRSS3 PARP16 PARP9 PARP14 PARP8 PARP10 SLC2A3 NT5E BST1 PCCA MMAA DHFR PCCB MMUT SLC23A2 MMAB CYB5A MMACHC MMADHC CYB5R3 SLC23A1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 NUP85 EIF4E NUP37 SEC13 NUP133 SLBP NUP205 POM121 NUP107 NUP188 AAAS TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 TNKS1BP1 PLK3 RGCC CNOT1 CNOT2 TP53 CDC25C CNOT3 NPM1 CNOT10 CNOT8 PLAGL1 CNOT11 CNOT9 CNOT6L BTG2 PLK2 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) SV2C SV2B SV2A VAMP1 VAMP2 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer PTPN6 TFG GZMB TPR FN1 RANBP2 JUN UBA52 IL10RA CCNB1 TYK2 DNMT1 CUL1 MDM2 RRBP1 MCL1 JUNB TWIST1 RNF213 UBB MSN IL22 UBC RPS27A CEBPB SEC31A CARS1 MAPK9 RBX1 MAPK8 RB1 CDKN1A HDAC1 KLC1 DCTN1 SQSTM1 STAT1 TPM4 TPM3 FRS3 MAPK1 STAT3 MAPK3 PLCG1 FRS2 PRF1 FOXM1 EEF1G ICOS ZC3HC1 TP53 RPS6 NPM1 IRF4 PPFIBP1 KIF5B LMO7 ALK IRS1 EML4 PPM1B HIP1 PRKAR1A PIK3CB BCL11A EIF2AK3 IL10 BCL2A1 STRN BIRC6 MYH9 STAT5A GRB2 ATIC PIK3R2 CLTC PIK3CA PIK3R1 WDCP GCC2 ZAP70 VCL MOV10 AGO3 AGO4 AGO1 AGO2 SKP1 TNRC6C MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 STAT3 MET HGF NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects HPRT1 APRT ADA ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System HLA-DRB3 HLA-DRB1 EZH2 H2AX PRKAG1 PRKAG2 DAPP1 CTSC ASH2L CD3G MAGT1 CD3E CD3D PRKAG3 CTLA4 RAC1 TEAD1 TEAD2 JAK1 SEC22B TEAD3 ERAP2 H3-3B HLA-DPA1 ERAP1 TEAD4 H3C8 FOS PDCD1LG2 VAV1 H2AJ B3GNT3 HLA-DQB2 HLA-DQB1 YAP1 SEC31A DERL3 DERL1 RAP1GAP2 DERL2 SIPA1 TRBV12-3 H3C15 PAK1 TRBV7-9 OS9 SPOP RICTOR HLA-DOA HLA-DOB PAK3 LAG3 PAK2 KIF20A BRD4 KLC1 SUZ12 H2BC9 KLC4 H2BC8 KLC3 H2BC5 KLC2 STAT1 OSBPL1A KIF11 H2BC3 STAT3 KIF15 CTSO MIB2 ACTR1B H2BC1 TRAV8-4 CTSH HLA-DPB1 CTSF CTSE FOSB KIF23 CD86 KIF22 TUSC3 HLA-DMA CD80 HLA-DMB TRAC RILP H2AB1 CD74 GRAP2 NEK2 KIF26A MAP3K8 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 BTLA THEM4 TNFRSF14 OST4 TRAV19 NFKB2 COPS5 OSTC STT3A HLA-DRA STT3B RNF185 MAP3K14 PRR5 GSK3B PIK3CD DPY30 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 LCK IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN CSK RBBP7 TCF7L2 H2AZ2 TCF7L1 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 TNRC6A AP2A1 TNRC6B AP2A2 PRKACG PRKACB ELOB AP2M1 MYLIP ELOC AP2S1 AP2B1 RAPGEF3 RAPGEF4 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 FBXL3 FBXL5 CD79B CD79A IGHM BLNK IGHD DCTN1 COLEC12 CALR CLTC CLTA CANX BLK HLA-B CD14 MRC1 CD33 HSPA5 CD300A TRPC1 AP1G1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A B2M AP1M2 AP1M1 PSME1 PSME2 PSMB10 PSMB8 PSMB9 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 CDC34 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ UBE2V1 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 PPL RASGRP2 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 ICAM2 IGLV7-43 IGKV1D-12 ICAM3 IGLV1-51 IGLV2-23 CD209 UBE2N TAB2 ITGB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 RAB7A V4-6 VAMP3 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YWHAZ S100A9 S100A8 ITGB2 ICAM4 ICAM5 ITGB7 ITGAV VASP XDH ENAH CUL2 RBBP6 NCK1 EVL CTSA ITGB5 ARF1 SEC23A SAR1B DNM2 VAMP8 SEC24B SEC24A SEC24D SEC24C PIK3R4 HMGB1 UBE2L3 PIK3C3 PRKN LRR1 CCNF KEAP1 CBLB UBE2L6 HERC5 DCAF1 HERC4 HERC3 ITCH RNF115 HERC2 RNF114 HERC1 TRIM21 STUB1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF123 RNF126 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 ATG7 HACE1 SIAH2 SIAH1 LNPEP MEX3C TRAT1 UBAC1 PIK3AP1 FBXL8 FBXL4 DZIP3 FBXL7 RNF220 DET1 LRSAM1 SH3RF1 TRIM9 TRIM4 ARIH2 LRRC41 RNF144B GAN RNF138 RNF130 HUWE1 KLHL2 UBE2G1 KLHL3 UBE2B UBE2G2 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 NEDD4 AHCYL1 RLIM TRIP12 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B PRKACA UBE3A UBE3B FBXO21 UBE2Z FBXO22 NPEPPS RNF19A KIF5C FBXW12 STIM1 ORAI2 AREL1 ORAI1 FBXW8 KIF5B UBE2E3 KIF5A FBXO17 UBE4A FBXO15 UBE2E2 ITPR1 LMO7 FBXO10 ITPR2 FBXO11 KLHL41 ITPR3 KCTD7 TRAIP RNF41 KLHL42 UBE2V2 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 KLHL11 UBR2 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 SOCS1 BTBD1 LONRF1 UBE2F UBE2H KLHL25 ZBTB16 GLMN KLHL21 KLHL22 UBE2A BTBD6 FBXO30 ITK FYB1 FBXO31 KLHL20 ZAP70 LCP2 UBE2W UBOX5 LAT UBE2U CD101 MKRN1 RNF182 UBA3 UBE2O TPP2 BLMH UBA1 UBE2K BTNL9 UBE2M BTNL8 TRIM71 BTN2A2 RNF14 BTN3A1 BTN2A1 KBTBD13 BTN1A1 UFL1 UBE2Q1 BTN3A3 UBE2Q2 BTN3A2 TRIM69 BTNL2 UNKL DTX3L PJA2 PJA1 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 RNF4 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 VHL TRIM41 RNF25 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 PLCG1 ASB9 LNX1 CD81 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 ASB2 TRIM32 ASB3 ASB1 CD19 NCF1 NCF2 NCF4 C3 SNAP23 CD22 CYBB CYBA RACGAP1 BECN1 CD8B BTK PLCG2 SYK WAS CXADR JAML CD99 FCGR3A SELL TREM1 FCGR1A CD226 CD1D CD1C CD1B INPP5D cd21 CD1A KLRK1 SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 KIR2DS2 ATG14 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 SIGLEC9 NCR1 NCR2 CD200R1 NCR3 HCST LILRA6 LILRA1 LILRA2 LILRA3 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA LAIR1 MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 LILRB2 KIR3DL2 LILRB3 LILRB4 LILRB5 CD40LG SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 SIGLEC5 CD96 OSCAR CD8A KLRF1 CD300E CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LB CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM HLA-H HLA-C KLRD1 HLA-F ULBP1 ULBP3 PIANP HLA-G HLA-E KLRG1 CLEC2B FCGR2B CLEC2D TLR1 PAG1 TLR6 TLR2 PDIA3 UBE2D3 PSMD8 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CARD11 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 RIPK2 DCTN5 BCL10 PSMA7 MYD88 DCTN4 RELA MALT1 PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 RAP1GAP PSMC4 PSMC1 PSMC2 PTPRC REL NFKBIE NFKBIB SOCS3 TREM2 TYROBP S100A1 CD36 FBXO32 TIRAP KIFAP3 PTEN ITGAL TRIM63 ITGA4 KIF3B KIF3A KIF3C ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ACTR1A ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SH3KBP1 CDH1 CTNNB1 SH3GL2 YWHAB NRAS RAP1A HRAS PVR CTSV CTSL CTSK DCTN2 SOS1 DCTN3 NECTIN2 IFITM1 IFI30 LY96 ICAM1 EP300 CREBBP VCAM1 TLR4 NFE2L2 PPP3CA PPP3CB PPIA RASGRP1 RASGRP3 PPP3R1 NFATC3 NFATC2 FCGR1BP NFATC1 FKBP1A CALM1 JUN RNF111 RBX1 NEDD4L WWP1 CTSD PTPRJ CUL3 KBTBD7 SPTBN2 KIF4B KIF4A FZR1 DNM1 CCND1 DNM3 SKP2 CDK4 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A PPP2R5E SEC13 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RNF34 DYNLL2 KIF2A KIF2C KIF2B DYNC1I2 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE TAP2 TAP1 CD207 SEC61A2 MRC2 SEC61A1 PTPN22 SEC61G SEC61B KCTD6 TAPBP STX4 CAPZB SMURF2 CAPZA1 CAPZA2 SMURF1 H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 TRBC1 CTSS AKT1 LGMN CTSB ICOSLG PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B TRIB3 ATF3 RPN2 EPAS1 MAPKAP1 RPN1 PIK3R3 PIK3R2 PIK3R1 RAP1B HIF1A PIK3R6 PIK3R5 TRAV29DV5 FGB HLA-DQA2 FGA LYN WWTR1 HLA-DRB5 FGG YES1 H4C9 HLA-DRB4 JUND ERLIN1 RAF1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 CD28 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs ALOX5 PTGS2 ALOX15 ALOX12 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 HEXA SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) CXCL8 SSTR3 C5AR2 C5AR1 RXFP4 RLN2 RLN3 INSL3 RXFP1 INSL5 RXFP2 RXFP3 OPN1SW C3 C5 ADRA1D ADRA1B ADRA1A CCR5 APP MC4R TBXA2R EDNRB EDN1 EDN3 MC3R OPN1MW CHRM2 CHRM3 CHRM1 POMC CHRM4 CHRM5 MC1R HTR2B HTR2C ADRB1 MC5R ADRB2 HTR2A HTR4 TAAR3P HRH1 HTR6 C3AR1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 CGA DRD4 DRD5 TSHB HTR1E TAAR8 TAAR9 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 CX3CR1 HTR5A TAAR1 GPR143 ADRB3 CXCR4 CYSLTR1 CYSLTR2 CXCL12 ADORA2B MRGPRD CMKLR1 PF4 PDYN AGTR2 FPR1 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR35 GPR31 RGR CCL13 CCL11 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 S1PR1 CCL19 CCL17 GPHA2 CCL16 P2RY12 CCL25 P2RY13 CCL22 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 GPHB5 CXCL13 CXCL16 ADORA3 ADORA1 LHCGR MTNR1A MTNR1B PSAP CXCL10 CXCL11 ECE1 ECE2 ANXA1 PRLHR ADORA2A CCL7 P2RY4 CCL5 CCL4 CCL3 CCL1 APLN RRH OXER1 PTGDR GPR37L1 KEL LHB NLN MC2R PENK PPY CCR10 CCR1 PPBP ADRA2C ADRA2B ADRA2A PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 FSHB GPBAR1 GAL FSHR PTGER4 OPRD1 NPB PTGER2 PTGER3 CXCR5 CXCR6 CXCR1 NPW CXCR3 CXCR2 PRLH MAS1 XK NPY2R CCRL2 NPY1R APLNR SUCNR1 CCL3L3 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY CXCL6 CXCL9 CXCL1 CXCL3 CXCL2 NPFFR2 CXCL5 NPFFR1 HEBP1 GRPR EDNRA PROK2 PROK1 UTS2R GPER1 NPFF TRHR UTS2B AGTR1 PTGFR LPAR1 RHO PTGIR LPAR2 NPY5R LPAR3 SSTR1 FPR2 SSTR2 LPAR4 SSTR4 HCRT SSTR5 NTSR1 CORT NTSR2 NPY4R GPR17 OPRL1 NMB CNR2 XCR1 CNR1 NMBR LPAR5 S1PR3 LPAR6 NMS S1PR2 NMU S1PR5 GNRH2 GNRH1 S1PR4 OXTR QRFP TSHR MLN AVPR1B NPY ACKR4 BRS3 AVPR2 ACKR3 OXT ACKR2 GPR132 AVP ACKR1 CCKAR AVPR1A GNRHR FFAR4 FFAR3 FFAR2 FFAR1 GPR39 EDN2 TACR2 TACR3 TACR1 F2 SAA1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH GHSR OPRM1 F2R LTB4R2 UTS2 NTS KNG1 MCHR2 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR TRH LTB4R OPRK1 MCHR1 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 P2RY6 P2RY2 P2RY1 CCK HCRTR2 HCRTR1 KISS1 SST CCL2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NOS1 LPO MPO TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B ATP6V1G1 ATP6V0E1 ATP6V1G2 NCF1 NCF2 NCF4 NOS3 HVCN1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 RAC2 ATP6V1B1 ATP6V1A SLC11A1 CYBB ATP6V0A2 ATP6V1H CYBA ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 NOS2 ATP6V1F ATP6V1C2 ATP6V0A1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery RPS2 FAU RPS27A RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 GEMIN2 RPSA SNRPD2 SNRPD1 SNRPD3 SNRPG RPS4Y2 GEMIN4 RPS4Y1 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters KMT2A BMAL1 CLOCK CREBBP EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling MYL12A EFNB2 PAK1 EFNB1 EFNB3 EPHB2 ARHGEF7 PAK3 PAK2 NCK2 GIT1 RAC1 EPHB6 EPHB1 FYN EPHB4 EPHB3 SDCBP KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS KERA OGN OMD HEXB PRELP HEXA ACAN GNS GLB1L3 GLB1L2 FMOD GLB1L LUM GLB1 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD2 GAD1 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 AMN CBLIF CUBN TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 KRAS UBA52 MAML2 MAML1 PSMD12 PSMD11 FOXO3 PSMD14 TEAD1 RUNX3 PSMD13 TEAD2 MDM2 TEAD3 PSMA7 CCN2 BCL2L11 CBFB TEAD4 PSMB6 RUNX1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SRC UBC PSMB1 YAP1 RPS27A ADRM1 SEM1 NOTCH1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN2A CCND1 HDAC4 SNW1 SMAD4 SMAD3 SMURF2 SMURF1 JAG1 TCF7 TP53 BRD2 KAT2B KAT2A SPP1 MAMLD1 ITGAL MYC TGFB1 HES1 ITGA4 EP300 RBPJ ZFHX3 CREBBP LEF1 WWTR1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TCF7L2 PSMD1 TCF7L1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation FGF9 FGF20 FGF23 GALNT3 FGF16 FGF18 FGF1 FGF2 FGF4 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism SLC27A1 CYP2C19 PTGES2 CYP2C9 CYP2C8 CYP1A2 CYP1A1 HPGDS PTGIS TBXAS1 CYP8B1 LTC4S ABCC1 ALOX15 CYP4F3 CYP4A22 PTGDS EPHX2 PRXL2B CYP4B1 PTGR2 CYP4F22 PTGS1 CYP4F11 CYP4F8 PTGR1 ALOX5AP FAAH2 AWAT1 MAPKAPK2 FAAH PTGES ALOX15B AKR1C3 CBR1 PLA2G4A PON3 PON2 PON1 GGT1 GPX2 DPEP2 ALOX5 DPEP1 PTGS2 CYP2U1 CYP4F2 CYP4A11 GGT5 CYP1B1 GPX1 GPX4 ALOX12B ALOX12 ALOXE3 PTGES3 HPGD LTA4H CYP2J2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling SOS1 PRKCE EREG BTC SHC1 PRKCD PRKCA NRG2 HBEGF NRG3 EGFR NRG4 NRAS HRAS EGF PTPN12 ERBB2 NRG1 MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease PPM1K BCKDHA DBT BCKDHB DLD PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines PAOX DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer SOS1 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF CBL MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters SLC8A1 SLC30A2 SLC39A4 SLC8A2 SLC39A6 SLC30A1 SLC41A2 SLC39A5 SLC41A1 SLC39A8 CALM1 SLC39A7 SLC39A2 SLC9A2 SLC39A1 SLC9A3 SLC39A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC24A1 SLC30A8 SLC24A4 SLC30A5 SLC40A1 HEPH SLC24A2 SLC24A5 SLC24A3 SRI SLC8B1 SLC11A2 SLC8A3 SLC11A1 SLC30A10 SLC39A10 SLC39A14 SLC31A1 CP SLC30A3 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions LYN PTPN6 YES1 ITGB3 PLCG1 PECAM1 ITGAV FYN LCK PTPN11 INPP5D RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR2K POLR2L TBP GTF3C1 GTF3C2 GTF3C3 CRCP GTF3C4 GTF3C5 GTF3C6 BRF1 POLR3GL POLR3A POLR3B POLR3C POLR3D POLR1C POLR3E POLR3F POLR1D POLR3G POLR3H BDP1 POLR3K POLR2E POLR2F POLR2H G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK BTK GNGT1 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling SOD1 VAMP7 SNRPA1 MTAP CFL1 ANXA2 IL12B IL12A GSTO1 SOD2 TALDO1 LMNB1 TYK2 JAK1 GSTA2 IFNG CA1 MSN IL10 PSME2 HNRNPF HSPA9 TCP1 PITPNA RALA SERPINB2 PAK2 AIP MIF RPLP0 RAP1B LCP1 JAK2 BOLA2B CNN2 HNRNPDL STAT4 IL12RB1 IL12RB2 ARF1 CDC42 PDCD4 P4HB HNRNPA2B1 PPIA CAPZA1 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation HTRA2 MRPS10 LONP1 MRPL32 SLC25A5 SLC25A6 SPG7 MRPS2 ECI1 AFG3L2 SMDT1 YME1L1 PMPCA MICU2 MRPL12 COX5B COX5A NADK2 DBT DLD GLUD1 CHCHD2 OXSM CLPX CLPP ALDH18A1 LDHD IARS2 CS UQCRQ TRIAP1 ACO2 SUCLG2 UQCRC2 TIMM17A PDHB NDUFS3 ALAS1 FECH TIMM22 MDH2 MT-ND6 TIMM9 SHMT2 TIMM10 MT-ND5 MT-ND2 BDH1 MT-ND1 ME2 OXCT1 PDK1 HMGCS2 ACAT1 PDHA1 FH MT-ATP6 ATP5F1A ACAD8 ATP5F1B NDUFA13 ACADSB ALDH2 ALDH1B1 ATP5MG TWNK HSPA9 STAR ATP5PF ATP5PD ECH1 SSBP1 PRELID1 ATP5F1C NDUFV3 HADH ACOT2 NDUFV1 ATP5PO IDH2 IDH3A STARD7 NDUFS1 NDUFB6 PRKACA ARG2 OMA1 OPA1 NDUFA2 COX4I1 HSPD1 MT-CO1 TFAM PCCB HSD17B10 MT-CO2 OGDH SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 MAPK7 MAP2K5 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle PPP6C ACD H2AX PPP6R3 GORASP1 MDM2 MDM4 H3-3B RAB1A H3C8 TERF1 RAB1B TERF2 USO1 H2AJ CCNA2 CCNA1 POT1 TERF2IP ANKRD28 H3C15 CDKN2D CDKN2B CDKN2C CDKN2A KIF20A H2BC9 H3-4 H2BC8 H2BC5 FBXL18 H2BC3 H2BC1 SET KIF23 GAR1 H2AB1 NEK2 H2AC8 H2AC6 CDC6 H2AC7 GSK3B H2BC26 H2BC21 YWHAG DKC1 H2BC17 NHP2 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 NOP10 RBBP4 RBBP7 H2AZ2 CDC14A PHF20 CHEK2 GTSE1 ZNF385A FKBPL COP1 PCBP4 PRIM2 PRIM1 POLA1 HJURP POLA2 RSF1 MIS18BP1 OIP5 CENPW CENPX MIS18A ESCO1 ESCO2 PTK6 LIN54 CKS1B LIN52 LIN37 LIN9 CABLES1 WEE1 PPME1 BORA OBI1 LCMT1 CDK11A CDK11B TUBB6 TICRR TUBB3 TUBB1 PRKAR2B TUBA4B TUBA4A TP53 TUBA8 WRAP53 TUBA1C TUBA1B SMARCA5 TUBA1A TUBB2B TUBB2A MDC1 TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 NUP214 SFN NDC1 LIG1 NUP210 SUN2 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SYCP2 SYCP1 ORC5 SYNE2 ORC4 SYNE1 ORC6 SUN1 TEX12 ORC1 MCM8 SMC1B ORC3 SYCE3 ORC2 SYCE2 SYCE1 REC8 NEK9 STAG3 NEK6 SYCP3 NEK7 HMMR KPNB1 PHLDA1 HSP90AA1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 KMT5A BTRC SKP1 PRKCB FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPO11 TEX15 MSH4 PSMD12 RAN DMC1 PSMD11 MSH5 PSMD14 PSMC3IP PSMD13 CUL1 MND1 MLH3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 OPTN PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 CPAP PSMC5 MAX PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TOP2A PIAS4 UBE2I FOXM1 SUMO1 AKAP9 MRE11 BRCA1 BRCA2 KAT5 EXO1 PRKCA FIRRM CHEK1 NBN PRDM9 CCP110 DSCC1 TOPBP1 RUVBL2 CEP250 SHQ1 POLE PIF1 CDK5RAP2 CHTF8 CTC1 RFC5 CEP135 RFC3 CHTF18 EML4 RMI2 CEP131 STN1 RFC4 CSNK1D TEN1 RFC1 RFC2 RMI1 TOP3A HUS1 RAD51C DNA2 RHNO1 BLM RTEL1 PCNA CEP70 POLD3 POLD4 CEP72 WRN VPS4A BRIP1 CEP192 FIGNL1 POLD1 E2F4 POLD2 CEP76 RBBP8 ATRIP E2F5 CEP78 BARD1 PLK4 E2F6 RPA1 ODF2 RPA2 POLE4 RAD50 RAD51 RPA3 POLE2 POLE3 RAD17 RAD1 ATM RAD9B ATR RAD9A ANAPC15 CEP57 ANAPC16 ANAPC7 CETN2 UBE2C PLK1 CEP164 UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A PCM1 CCNB1 CDC23 UBE2S CDC26 CNTRL CDC27 ARPP19 CDC16 NCAPH2 CDK1 NCAPG2 ANAPC4 NIPBL ANAPC5 ENSA ANAPC1 TNPO1 NCAPD3 ANAPC2 RAB2A CEP290 NINL CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL RAB8A GORASP2 OFD1 MCPH1 PPP2R2D TUBB HAUS4 HAUS3 HAUS6 HAUS5 YWHAB TUBG1 HAUS2 MAPK1 HAUS1 CEP63 MAPK14 SFI1 MAPK11 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 NPM1 PCNT CEP152 CSNK1E CSNK1A1 NEK11 NEDD1 TERT ALMS1 CEP41 CEP43 XPO1 UBE2N EP300 ANKLE2 FKBP6 PTTG1 EMD YWHAQ HSPA2 MYBL2 LEMD3 RCC1 AURKA RRM2 YWHAE PPP1R12A CDC25C CDC25A CDC25B LMNB1 GOLGA2 YWHAH SMC4 SPAST SMC2 CC2D1B SIRT2 TUBGCP2 NCAPG TUBB8 NCAPH IST1 VRK1 TUBGCP5 LEMD2 TUBGCP6 TUBB8B TUBGCP3 TUBGCP4 ESPL1 RBX1 NUMA1 YWHAZ TUBG2 MZT2B MZT2A NME7 MZT1 PPP1CB NCAPD2 PLK3 HDAC1 CDC7 LPIN1 LPIN2 LPIN3 PPP2R2A HSP90AB1 FBXO5 DYRK1A DHFR TK1 TYMS PPP2R3B GINS1 GINS2 CDC45 MCM7 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 ABL1 E2F3 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT LBR STAG1 KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RUVBL1 RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 BIRC5 CHMP4A KIF2C CHMP6 KIF2B CHMP7 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CHMP2B CLASP1 HERC2 DYNC1I1 CHMP2A CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ GMNN TPX2 SPC24 MAD2L1 CENPS NUP37 CDT1 SPC25 FEN1 MCM10 DBF4 FBXL7 MLH1 RPA4 PKMYT1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E BRCC3 POLR2F POLR2G CLSPN POLR2H TP53BP1 POLR2I BABAM1 POLR2J BABAM2 POLR2K UIMC1 RNF168 POLR2L ABRAXAS1 RNF8 PRKACA NSD2 CDK7 MNAT1 RBL2 H2AC19 RBL1 H2AC14 H2BC12L AKT2 MYC AKT3 AKT1 UBE2V2 CSNK2A1 CSNK2A2 CSNK2B JAK2 LYN H4C9 TINF2 AJUBA H2AC20 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle POM121C NUP42 NUP62 FURIN TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP107 NMT2 NUP160 NUP85 XPO1 SEC13 NUP133 PDCD6IP RANGAP1 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 PPIA RCC1 NUP43 NMT1 CCNK CHMP2B RANBP1 CCNT2 CHMP2A ELL CCNT1 RANBP2 GTF2B UBA52 TAF7L ELOA RAN ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 UBB CTDP1 TAF9 SUPT4H1 UBC TAF1L GTF2E1 GTF2E2 RPS27A NUP37 TAF15 TAF12 TAF13 TAF10 TAF11 ELOA2 SSRP1 NEDD4L CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TSG101 VPS4B VPS4A MVB12B MVB12A VTA1 VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 CHMP5 NUP205 POM121 NUP188 AAAS IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DLD DLST DHTKD1 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition PPP2CA PPP2CB PPP2R1B PPP2R1A PPP2R2A SGO1 PLK1 CDC25C CDC25A CDK7 CCNB1 CDC25B MNAT1 HJURP MIS18BP1 CDK1 CCNB2 CCNA2 CCNA1 XPO1 PKMYT1 FZR1 WEE1 PPME1 BORA OBI1 LCMT1 PPP2R3B CCNH TICRR CDK2 FOXM1 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle RHOT1 RAP1GDS1 TRAK1 MYO19 TRAK2 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation SERPINA1 LAMB2 FN1 F5 LAMB1 LAMC1 MEN1 IGFBP1 IL6 GPC3 IGFBP3 VCAN PDIA6 VGF APOE WFS1 FSTL1 CP CHRDL1 TF ADAM10 MBTPS1 PENK SPP1 CDH2 BMP4 FGF23 C3 APOB C4A APOA1 PNPLA2 DNAJC3 CKAP4 PCSK9 APP CSF1 APOA2 TGOLN2 APOA5 KTN1 CALU SERPINC1 MFGE8 CST3 GAS6 ALB QSOX1 PRKCSH AHSG P4HB PROC TNC SPP2 TIMP1 DMP1 LGALS1 EVA1A CCN1 APLP2 FBN1 CHGB IGFBP5 IGFBP4 SCG3 MGAT4A SHISA5 MXRA8 SPARCL1 SCG2 SDC2 STC2 KNG1 AMELX AMBN LTBP1 TMEM132A FUCA2 BPIFB2 HRC MELTF HSP90B1 SERPINA10 MIA3 MSLN PRSS23 BMP15 MEPE RCN1 ENAM AMTN FAM20C VWA1 FAM20A MATN3 ITIH2 AFP FSTL3 APOL1 FGA SERPIND1 GOLM1 FGG NUCB1 NOTUM IGFBP7 ANO8 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC27A1 CYP2C19 ACBD5 PRKAG2 PTGES2 CYP2C9 CYP2C8 CYP1A2 CYP1A1 HPGDS ECI1 ACADM DECR1 ACOT9 ACOT7 ACOT1 ELOVL6 MCAT PTGDS PRXL2B ACOT7L PTGR2 ACADVL PTGS1 THEM5 FADS2 FAAH2 FADS1 ACACA HADHB HADHA AWAT1 MAPKAPK2 PCTP ACADL SLC25A20 MID1IP1 FAAH ACAD11 ACAD10 PPARD CPT1B PTGES ALOX15B THEM4 CBR1 SCD ACAA2 ACOT11 ACBD4 ACOT12 ACOT13 ACBD7 ACSL1 ACBD6 ACSF2 DBI CPT2 PON3 PON2 PON1 GPX2 ALOX5 PTGS2 ELOVL5 SLC25A17 THRSP PRKAA2 GPX4 ALOX12B ALOX12 ALOXE3 SLC22A5 ACOT8 EHHADH HSD17B4 ACAA1 PECR HACD1 DECR2 TECR ABCD1 PTGIS SLC27A2 TBXAS1 HSD17B3 ACOT4 CROT HSD17B12 HACD3 CYP8B1 SCP2 HACD2 NUDT19 HSD17B8 HACD4 HTD2 FASN PHYH MORC2 CBR4 ELOVL1 OLAH ELOVL4 ELOVL2 ACSL6 ACOX2 ACSL5 ECHS1 ACSM3 ACSL4 ELOVL3 ACSM6 ELOVL7 HADH ACSL3 ACOT2 LTC4S TECRL ACADS ACOX3 ACSF3 ACLY PPT1 HACL1 ACSBG1 PPT2 ABCC1 SLC27A3 ALOX15 HAO2 CPT1A CYP4F3 ACSBG2 EPHX2 CYP4A22 CYP4B1 CYP4F22 CYP4F11 NUDT7 CYP4F8 AMACR PTGR1 RXRA SCD5 ALOX5AP CRAT ACOXL AKR1C3 PLA2G4A PRKAB2 MECR GGT1 DPEP2 DPEP1 CYP2U1 CYP4F2 GGT5 CYP4A11 CYP1B1 MCEE NDUFAB1 PCCA MMAA PCCB MMUT GPX1 PTGES3 HPGD LTA4H CYP2J2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type CSPG5 CSPG4 SDC1 B4GALT7 GPC1 HSPG2 GPC3 GPC2 SDC4 NCAN SDC2 GPC5 SDC3 GPC4 BGN DCN GPC6 BCAN VCAN AGRN REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 CUL1 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FZR1 CDK2 BUB1B CDC20 FBXO5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation CHUK UBE2V1 APP UBA52 TP53 NFKB2 RIPK2 RELA UBB NKIRAS1 NKIRAS2 UBC IKBIP RPS27A HMGB1 NFKB1 CASP8 NFKBIA UBE2N TIFA TAB3 TAB2 ALPK1 TAB1 IRAK1 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 TRAF2 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B IKBKB SAA1 TRAF6 IKBKG MAP3K7 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization CIDEC HSD17B13 HILPDA CIDEA FITM1 FITM2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity GRIP2 GRIA1 PRKCB AP2A1 EPB41L1 TSPAN7 GRIA3 GRIA4 PRKCA MDM2 CAMK2B CAMK2D CAMK2A DLG1 DLG4 GRIA2 AKAP5 CAMK2G PICK1 CACNG8 MYO6 CACNG2 CACNG3 CACNG4 GRIP1 NSF PRKCG REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6A TNRC6B REST SRF NPAS4 NR3C1 MOV10 AGO3 AGO4 KCNIP3 AGO1 AGO2 TNRC6C PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair PCMT1 MSRA TXN MSRB2 MSRB3 MSRB1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint RAD1 ATM RAD9B H2AX ATR RAD9A YWHAE HERC2 SFN CHEK2 CDC25C CCNB1 CDK1 YWHAH CCNA2 CCNA1 YWHAZ H2BC9 H3-4 YWHAB PIAS4 H2BC8 WEE1 H2BC5 H2BC3 H2BC1 BRCC3 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 EXO1 CHEK1 NBN TOPBP1 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC2 RMI1 H2BC26 TOP3A UBE2V2 H2BC21 HUS1 YWHAG UBE2N DNA2 MDC1 H2BC17 RHNO1 BLM H2BC12 H2BC13 H2BC14 H2BC15 WRN BRIP1 H2BC11 RBBP8 ATRIP BARD1 H4C9 RPA1 RPA2 YWHAQ RAD50 RPA3 RAD17 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD CBLIF REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate DNA2 PCNA POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RPA1 RPA2 RPA3 FEN1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis NCOR1 NR1H2 FABP6 RXRB NCOA1 UGT1A3 RXRA NR1H3 NCOR2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL OFD1 CPAP TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA TGFA TFAP2A TFAP2B KIT TFAP2C CGB8 EGFR VEGFA ESR1 YY1 ERBB2 ATAD2 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein GSK3A PRMT1 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 PARP10 SRPK2 SRPK1 UBE2I CSNK1A1 GSK3B SUMO1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35C1 SLC35D1 SLC35B4 SLC35D2 SLC35A2 SLC35B3 SLC35B2 SLC35A1 SLC35A3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3L1 CREB3L2 MBTPS2 MBTPS1 CREB3 CREB3L3 DCSTAMP CREBRF CREB3L4 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 PARL AFG3L2 PHB1 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU STOML2 MCUB SPG7 PHB2 MAIP1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma TGFA PLCG1 EGF EREG BTC AREG EPGN HBEGF EGFR PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis GSDMD GZMB CHMP2B CHMP2A CYCS BAX TP53 GSDME HMGB1 CASP5 CASP4 CASP1 TP63 IL18 IL1A IRF1 IL1B IRF2 CASP3 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 BAK1 ELANE BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 GSTT2 CYP1A1 GSTT1 AHRR OPLAH CYP2E1 CNDP2 CYP2F1 HPGDS TPST2 ESD CHAC2 CHAC1 TPST1 GSTT2B GSTM4 CYP24A1 GSTM3 GSTM2 GSTO2 GSTZ1 GGCT GSTA5 GSTA4 GSTM5 PTGS1 CYP19A1 GSS NCOA1 CYP11A1 NCOA2 CYP2R1 AOC1 CES2 CES3 PTGIS TBXAS1 CYP4F12 CYP8B1 GSTK1 POMC PAOX UXS1 GSTM1 TPMT GSTA2 GSTA1 SLC35D2 UGT1A3 HSP90AB1 GGT1 DPEP2 DPEP1 CYP11B2 CYP21A2 CYP2U1 CYP4F2 GGT5 CYP4A11 CYP1B1 MAOB AKR1A1 PTGES3 UGT1A10 ABHD10 UGT2B10 UGT2B11 UGT2B15 ACY1 UGT2B17 SLC35D1 UGT3A2 UGT3A1 NAT1 NAT2 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGDH UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGT1A6 BPHL CBR3 HEMK2 AADAC NNMT MTRR AHCY GSTO1 AOC3 AOC2 MTR CMBL MAT1A CYP51A1 MTARC2 MAT2B MTARC1 COMT TRMT112 AS3MT NQO2 CYB5B MAT2A ALDH3A1 EPHX1 FMO2 FMO3 GLYATL3 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 GLYAT ALDH1A1 CYP4V2 NR1H4 CYP7B1 UGP2 CYP7A1 CYP27A1 ACY3 GGT7 PODXL2 GGT6 ABHD14B MGST3 SULT1A1 MGST1 SULT1C2 MGST2 SULT1B1 FMO1 SULT1E1 AKR7L AKR7A2 BPNT2 AKR7A3 BPNT1 GGT3P SULT6B1 SULT1A4 SULT4A1 SULT1A3 SULT1A2 SULT2A1 SULT1C4 ADH4 ACSS2 ALDH2 ALDH1B1 ADH1C ADH1B ADH1A ADH7 ACSS1 ADH5 ADH6 ARNT2 ACSM1 ACSM2B CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 RXRA CYP26A1 CYP26B1 FDX1 CYP26C1 FDXR FDX2 MAOA CES1 ARNT CYP46A1 CYP39A1 POR CYP27B1 GSTP1 CYP11B1 GSTA3 AIP GCLC GCLM CYB5R3 CYP2J2 CYP3A43 AHR METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins LTF S100A7A S100A7 S100A9 S100A8 LCN2 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels HCN4 HCN3 HCN2 HCN1 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants HRAS KRAS NRAS PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis SLC8A1 SLC8A2 CALM1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 TRPC7 TRPC6 TRPC3 P2RX6 P2RX5 P2RX7 P2RX3 P2RX4 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) CSF3 KRAS SYK UBA52 UBE2D1 ELOB ELOC TYK2 JAK1 UBB RNF7 UBC RPS27A CUL5 STAT5A STAT5B HCK GAB2 GRB2 SOCS3 SOCS1 SHC1 JAK2 UBE2D2 STAT1 LYN STAT3 UBE2D3 CSF3R PTPN11 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases RAC1 FOS TCIRG1 VAV1 ATP6V1E1 ATP6V1E2 ATP6V0B YAP1 ATP6V1G1 ATP6V0E1 ATP6V1G2 SHB SH2D2A ATP6AP1 PAK1 MAPK7 NOS3 ATP6V1B2 ATP6V0D1 RICTOR ATP6V0C ATP6V0D2 PAK3 PAK2 ATP6V1B1 ATP6V1A NTRK2 DOCK3 STAT1 BDNF GAB1 FRS3 STAT3 ATP6V0A2 GRIN2B ATP6V1H NTF4 ATP6V0A4 TIAM1 ATP6V0E2 NTF3 ATP6V1G3 PLCG1 FOSB ATP6V1D ATP6V1C1 EGF ATP6V1F AREG ATP6V1C2 ATP6V0A1 GRAP2 MYCN CD274 ADAM10 PRKCE ADAM17 THEM4 FGFRL1 PTPRS PTPRF HGF PRR5 FGFBP1 FGFBP2 PIK3CB FGFBP3 MLST8 NCKAP1 NCF1 NCF2 NCF4 PDPK1 BRK1 LTK TNK2 PIK3CA PLAT LCK COL4A2 COL4A1 CYBB EPS15L1 COL6A2 JUP CYBA COL4A4 EPN1 CDC42 COL6A1 COL4A3 ARF6 FYN COL9A1 DIAPH1 CSK COL6A3 NCKAP1L PTPN11 COL4A5 WASF1 MTOR COL9A3 WASF2 COL6A6 COL9A2 PTPN6 COL6A5 BAIAP2 AP2A1 ABI2 AP2A2 ABI1 ARHGEF7 PRKACG PRKACB NELFB AP2M1 DNMT1 SPARC PDGFRA NCBP1 NCBP2 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B IDE PDGFB KDR ELMO1 AP2S1 PTK6 AP2B1 PTK2B CYFIP2 VEGFB VEGFC VEGFD PLG AAMP SPHK1 BCAR1 HNRNPA1 CTNNA1 GRB7 WASF3 FAM83B IL2RG JAK3 MMP9 HNRNPM HNRNPF GABRG3 GABRG2 PTBP1 GABRB3 GABRB2 EGFR GABRB1 FLT1 SPP1 HSPB1 PDGFD CILP MXD4 NRG1 CSN2 THBS4 THBS3 STMN1 PTPRK HNRNPH1 LRIG1 ADAP1 FAM83D PAG1 FAM83A SPRY1 CLTC CLTA GABRQ SPINT1 GABRA1 MST1 HPN HSP90AA1 SPINT2 MST1R PTPN3 PRKCB PGF UBA52 ATF1 UBB DOCK7 TNS4 TNS3 UBC MEF2A RPS27A DUSP4 DUSP3 VRK3 DUSP6 ADAM12 DUSP7 FLT3LG AXL S100B PTPN18 ESR1 ESRP1 PGR PTPN2 ANOS1 PRKCA CHEK1 ALK MATK SRF PTPN1 LAMA5 LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 LAMC2 LAMB1 LAMC1 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL HGS CTNNB1 EPS15 MET TGFA STAM2 SH3GL2 SH3GL1 RALA SHC2 RALB SHC3 SHC1 YWHAB CRKL APOE NRAS RAP1A MAPK1 HRAS RALGDS MAPK3 NTRK1 MAP2K1 MAP2K2 KIDINS220 FRS2 CDH5 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 RIT2 MAPKAPK3 MAPKAPK2 RAPGEF1 SOS1 CRK MEMO1 NRG2 NRG3 NRG4 ATF2 VEGFA PTPRO HDAC3 PXN PRDM1 PRKCZ RHOA RPS6KA5 EP300 TAB2 ID4 ITGB1 EGR1 CYFIP1 MEF2D MEF2C NCOR1 GFAP CHD4 ELMO2 DOCK1 INS CALM1 REST PTPRZ1 JUNB CDK5 RPS6KA1 ERBIN CDK5R1 GGA3 KIT HDAC1 TIAL1 TIA1 RBFOX2 ESRP2 RAB4A ID1 CAV1 ADCYAP1 ADCYAP1R1 VAV3 ITGAV PTK2 EGR2 TCF12 VAV2 IGF1R FLRT3 NRP1 IRS4 IGF2 IGF1 ROCK1 ROCK2 STAT5A STAT5B GRB2 CXCL12 WWOX NCK2 NCK1 WWP1 CDC37 CTSD PTPRJ SPRED2 FURIN SPRED1 PCSK6 PCSK5 RASA1 FLT4 MDK NAB1 NAB2 ARC TRIB1 TPH1 RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 NRP2 LYL1 F3 VGF ELK1 ASCL1 EREG CDK5R2 BTC EPGN DNM1 HBEGF DNM3 ADORA2A RAB4B RANBP9 FLT3 PTPN12 FLRT2 FLRT1 DNM2 PPP2R1B PPP2R1A SOCS6 KLB IRS1 DLG4 PDE3B PIK3R4 IRS2 FGF1 SIN3A FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 THBS2 FGF22 GAB2 FGF16 FGF19 MKNK1 FGF18 SPRY2 HGFAC TLR9 PIK3C3 FGFR4 HDAC2 FGF10 PPP2R5D ITGA3 ITGA2 GALNT3 MUC20 PPP2CA PPP2CB ITCH BAX STUB1 PDGFRB NTRK3 PTPRU SH2B3 SGK1 SH2B2 CMA1 FER TEC FES GRAP POLR2A POLR2B POLR2C POLR2D NEDD4 POLR2E AHCYL1 POLR2F POLR2G POLR2H POLR2I RANBP10 POLR2J POLR2K POLR2L PRKACA TGFBR3 GTF2F1 GIPC1 GTF2F2 PRKCD ITPR1 ITPR2 AKT2 MYC ITPR3 AKT3 THBS1 AKT1 RNF41 ERBB2 CUL5 USP8 TRIB3 ITGB3 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 HIF1A RAP1B SOCS1 JAK2 GRB10 INSR LYN RPS6KA3 RPS6KA2 YES1 JUND PTN ALKAL2 STAT6 ALKAL1 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 LAMC2 UBA52 LAMB1 LAMC1 RAC1 UBB SH3GL3 DOCK7 SH3KBP1 TNS4 TNS3 SRC UBC RPS27A STAM CBL HGS EPS15 MET STAM2 SH3GL2 SH3GL1 GGA3 CRKL NRAS GAB1 RAP1A RAB4B STAT3 HRAS RAB4A RANBP9 RANBP10 PTPN2 RAPGEF1 SOS1 CRK PTK2 HGF USP8 LRIG1 ITGB1 HGFAC PIK3CA PIK3R1 RAP1B ITGA3 SPINT1 ITGA2 HPN SPINT2 ARF6 PTPN1 PTPRJ MUC20 PTPN11 LAMA5 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 FRS3 HRAS NTF4 SOS1 FRS2 NTRK2 PTPN11 NRAS BDNF INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane GET4 CAMLG HMOX1 APP PRNP VAMP2 STX1A UBL4A BAG6 SEC61G STX5 SGTA SEC61B VAPA EMD OTOF GET1 SERP1 GET3 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere ACD PRIM2 DSCC1 PRIM1 POLA1 POLA2 CHTF8 RFC5 CTC1 CHTF18 RFC3 STN1 RFC4 TERF1 TEN1 RFC1 TERF2 RFC2 POT1 TERF2IP PCNA POLD3 POLD4 POLD1 POLD2 TINF2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 GSK3B UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCND1 PSMD8 PSMD6 CDK4 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia IVD RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription HSPA8 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA3 CA7 CA9 CA14 CA6 CA13 CA5B CA1 CA5A CA2 CA4 CA12 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion INMT BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME CYP2C19 ITPA CYP3A4 CYP2C9 CYP2C8 CYP2D6 RAC1 GSTT1 CNDP2 CYP2E1 VAV1 UGT1A10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 ACY1 UGT3A2 UGT3A1 NAT1 NAT2 UGT2A3 UGT2A2 ABCG2 UGT2A1 UGT1A1 UGT2B4 UGT2B7 PCK1 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGT1A6 BSG SLCO1B1 SLCO1B3 SLC22A2 SLC22A1 HSD11B1 SLC29A3 HSD11B2 SERPINA6 SLC16A1 PON3 BCHE GLYATL3 PON1 GLYATL2 GLYATL1 ACSM2A ACSM5 ACSM4 GLYAT ABCC2 AKR1C1 SLCO1A2 SLC22A8 GGT7 GGT6 SULT1A1 SULT1E1 GGT3P SULT1A4 SULT1A3 SULT2A1 SULT1C4 CES2 ADH1A ACSM2B MAPDA ALB ADK ABCC1 PNP ADA VAV3 ABCC4 GSTM1 TPMT ABCC5 NME2 GMPS NME1 VAV2 IMPDH1 GUK1 GSTA2 IMPDH2 GSTA1 HPRT1 SLC28A2 CES1 SLC29A1 NUDT15 UGT1A3 XDH SLC29A2 SLC28A3 SLC22A3 ABCB1 GGT1 GSTP1 GGT5 ABCC3 NT5C2 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling LEF1 CTNNB1 MYC TCF7 TCF7L2 TCF7L1 CCND1 RUNX3 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD4 SMAD3 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 IRS1 PIK3CA PIK3R1 SRC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly LAMB3 ITGA6 LAMA3 DST COL17A1 LAMC2 PLEC CD151 ITGB4 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin SLC6A4 MAOA ALDH2 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle PRKAA2 SLC25A20 MID1IP1 PRKAG2 CPT1A PPARD CPT1B CPT2 PRKAB2 SLC22A5 RXRA THRSP NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis PFAS ATIC PPAT ADSL GMPS IMPDH1 CAD IMPDH2 UMPS GART PAICS DHODH ADSS1 ADSS2 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion MTERF3 MTERF4 FASTKD2 TFB1M NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM1 MRM2 MRM3 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 PPP2CA PPP2CB UBA52 NCBP1 NCBP2 UBB UBC RPS27A CBL HNRNPM HNRNPF TIAL1 TIA1 RBFOX2 ESRP2 NRAS GAB1 FRS3 MAPK1 HRAS MAPK3 PLCG1 POLR2A FRS2 POLR2B POLR2C BRAF POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I PTBP1 POLR2J POLR2K PPP2R1A POLR2L SOS1 GTF2F1 GTF2F2 FGF1 FGFBP1 FGF2 FGFBP2 FGF3 FGFBP3 FGF4 FGF6 FGF7 FGF9 FGF20 HNRNPA1 HNRNPH1 FGF23 FGF22 FGF16 MKNK1 FGF18 SPRY2 PIK3CA PIK3R1 FGF10 PTPN11 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors S1PR2 S1PR5 S1PR4 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 S1PR1 LPAR1 LPAR2 LPAR3 LPAR5 S1PR3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR PIGS GPAA1 PIGU PIGK PIGT PLAUR PGAP1 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 SEL1L PSMA2 UBA52 DHH PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HHAT ADRM1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 IHH SYVN1 SHH ERLEC1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling UBE2D1 FOS MAPK9 MAPK8 MAPK7 ELK1 MAPK10 UBE2D2 MAPK1 MAPK3 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 TBK1 PPP2R1A MAPKAPK2 IRF3 UBE2V1 ATF2 NFKB2 LY96 HMGB1 RPS6KA5 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 RIPK3 PPP2R5D MEF2C TRAF2 UBE2D3 IKBKB TLR4 BIRC2 TRAF6 BIRC3 RIPK1 IKBKG BTRC FADD PTPN11 MAP3K7 SKP1 CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 RELA RPS6KA1 TICAM2 TICAM1 TANK TRAF3 ATF1 UBB CD14 IKBKE OPTN NKIRAS1 UBC NKIRAS2 IKBIP MEF2A RPS27A DUSP4 NFKB1 DUSP3 VRK3 NFKBIA DUSP6 DUSP7 LRRC14 USP14 NLRX1 NFKBIB NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 TP53 TIFA ALPK1 RPS6KA3 RPS6KA2 MAP2K3 IRF7 MAP2K4 MAP2K7 MAP2K6 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling ATP5MF ATP5ME DMAC2L ATP5PF ATP5PD ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5MC2 ATP5PO ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP5MK ATP5MJ ATP5MG SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 CDK5 TIAM1 CDK5R1 NTRK2 RAC1 BDNF ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation RAP1A NTRK1 CRK KIDINS220 BRAF NGF YWHAB MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis MOCS2 MOCS3 GPHN MOCOS INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing CPSF4 PABPN1 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD MAT1A CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 BUB1B CDC20 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response PDE12 OASL OAS2 OAS1 OAS3 RNASEL RIGI ABCE1 FLNA VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways EZH2 MAGT1 RAC1 JAK1 H3C8 VAV1 H3C15 RICTOR PAK2 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 ATP6V1H H2BC1 TUSC3 NEK2 H2AC8 H2AC6 H2AC7 ZBP1 TBK1 TMEM258 IRF3 VCP OST4 OSTC STT3A STT3B PRR5 GSK3B H2BC26 H2BC21 MLST8 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 LCK H2BC11 RBBP4 FYN RBBP7 PTPN11 MTOR CD4 PTPN6 PDCD1 HDLBP AP2A1 CCNK CCNT2 AP2A2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB AP2M1 ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 FIP1L1 TAF11 ELOA2 SSRP1 AP2S1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 AP2B1 GJA1 P4HB HSPG2 SDC4 SDC2 SDC3 LIG4 XRCC4 SDC1 NUP205 ARID4A POM121 ARID4B FNTA NUP188 FNTB PSIP1 AAAS IL1R1 SAP30 POM121C BRMS1 NUP42 NUP62 IFNAR1 PHF21A TPR BANF1 CD79B NUP88 CD79A RAE1 SUDS3 KPNA1 RCOR1 IGHM NUP214 NDC1 BLNK HMG20B NUP210 JAK3 NUP155 GPC1 HMGA1 IFNGR1 NUP153 IFNGR2 SIGMAR1 NUP93 GPC3 NUP50 TYK2 IGHD NUP35 GPC2 NUP54 SAP30L SLC25A5 S1PR1 SLC25A4 SAP18 GPC5 CRBN SLC25A6 GPC4 STAT2 GPC6 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 AGRN CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 RPL4 PAPOLA SYMPK RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 TKFC RPL35 KPNA4 RPL38 KPNA5 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 KPNB1 RPS4Y2 RPS4Y1 RPL39L CPSF4 RPL41 TGFB1 MLKL EIF2AK2 ISG15 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 CDC73 HSPA1A HLA-B SKIC8 RUNX1 CTR9 TRAF3 RTF1 CD14 IKBKE LEO1 PAF1 FASN RNASEK PROS1 CLDN1 HNRNPU MTA1 MRC1 EMC4 CD33 MTA3 HSPA5 CD300A TIMD4 MERTK EIF4A3 AXL TYRO3 MAPRE3 GAS6 LY6E CDC40 SRRM1 SRSF2 SRSF3 GSK3A SRSF4 PARP6 SRSF5 PARP4 SRSF6 GALNT1 SRSF7 PARP16 PARP9 SRSF9 PARP14 PARP8 PARP10 PRKG2 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 VPS25 VPS28 CHMP5 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 ANO10 HLA-A B2M AP1M2 AP1M1 TUFM IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 IGKV2D-30 NMT2 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 CSNK1A1 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CD209 UBE2N TAB3 TAB2 TAB1 ITGB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 RCC1 IGKC DOCK2 NMT1 IGLV3-21 CCR5 IGKV1-39 IGKV1-33 RANBP1 IGHV3-53 IGLC7 IGKV5-2 IGKV1-5 IGLC6 YWHAH YWHAZ PPP1CB HDAC1 PPP1CA CAV1 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 SIKE1 MAVS IFNA10 RIGI SRPK2 SRPK1 CX3CR1 RAB5B IMPDH1 RAB5C IGF1R NCL IMPDH2 RAB5A NRP1 HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 CPSF7 NCK1 VIM HNRNPC RBMX FURIN DPM1 DPM2 DPM3 RPTOR EIF4E EIF4G1 TMPRSS2 ACE2 HAVCR1 ELK1 ARF1 SEC23A SAR1B HSPA8 SCAP SEC24B SEC24A COMT SP1 SEC24D SEC24C PIK3R4 CASP1 TLR9 PIK3C3 PDCD6IP RIPK3 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 IL6R RIPK1 KEAP1 UBE2L6 HERC5 ITCH CHMP2B CHMP2A ATG7 TRIM4 F2 ATP1B3 ATP1B2 ATP1B1 CAMK2B CAMK2D CAMK2A ATP1A4 ATP1A3 ATP1A2 ATP1A1 CAMK2G CUL5 UBA7 UBA6 UBA5 UBR4 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 UBA3 UBA1 IFNB1 VHL ELAVL1 C4BPA C4BPB BCL2L1 CLU EEF1A1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 PATJ SNRPE GEMIN6 PALS1 CRB3 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 C4A C4B_2 H2BC18 BECN1 UVRAG MAP1LC3B ISCU HCK CD8B ELMO1 ACOT2 ST6GALNAC2 PRKCSH ZDHHC20 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 BTK MGAT1 MGAT2 GOLGA7 PLCG2 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 LARP1 EDEM2 GRPEL1 MOGS HYOU1 SYK ZDHHC11 MED19 MGAT4C MED18 ZDHHC9 PQBP1 MGAT4A MED11 MGAT4B MED29 MAN1B1 MED28 ST6GALNAC3 MED22 ST6GALNAC4 MED21 ATL2 SRRT VPS33A VPS33B ZCRB1 SNRNP200 PYCARD G3BP1 G3BP2 FUS NACA CYSLTR1 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA0 HNRNPA3 GPKOW CNBP CDC5L KDELR1 NLRP3 CCAR1 CD2BP2 PCBP1 PCBP2 RBM10 MED13L BST2 RETREG1 SUGP1 DHX15 DHX16 UFD1 ARIH1 SFTPD BCAP31 PEX19 NLRP12 HNRNPA2B1 IL17F IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG PPIB RTN3 DDX3X DDX46 DDX42 SFN RBM17 LIG1 SUN2 DYNLT1 BUD31 MMP9 RBM22 DDX23 RRBP1 SMNDC1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM HNRNPK NPLOC4 HNRNPF HNRNPD CLINT1 MED16 SF3B4 MED15 SF3B5 MED17 SF3B2 SF3B3 MED12 SF3B6 MED14 SF3B1 MED13 SF3A3 SF3A1 SF3A2 MED10 XAB2 PHF5A HSPA1B CLEC4M AUP1 IPO7 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 MED27 P4HA2 MED26 P4HA3 RCAN3 EIF4G3 MED23 EIF4G2 MED25 EIF4E3 MED24 PTBP1 MED20 PLRG1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 VPS41 EGFR NPIPB3 VPS45 PPIL3 PPIL4 PPIL6 SRRM2 AQR HLA-H HLA-C HLA-F CRNKL1 HLA-G MBD3 HLA-E NMI PRPF19 CHMP1A TOMM70 IL17RC IL17RA TLR1 GATAD2B HNRNPH1 GATAD2A HNRNPH2 TLR6 TLR2 SPCS3 SPCS2 SPCS1 CWC25 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 PSMD8 OAS2 IKBKB PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RIPK2 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NFKBIB MED30 NOD1 NOD2 MED31 IRAK2 UBE2I NR3C1 SUMO1 ITGA4 CCNC TRIM28 SH3KBP1 CTNNB1 TUBB YWHAB SNW1 CTSL EXOC1 SOS1 NPM1 GBF1 HDAC3 LY96 XPO1 EP300 TBL1X IRAK1 MED1 CREBBP APOA1 NCOR1 TBL1XR1 CHD4 CHD3 TLR4 NFE2L2 YWHAQ PPIA FKBP1A MTA2 YWHAE COG1 REST MED8 MED4 MED6 MED7 RBX1 NEDD4L NCOR2 TAL1 GPS2 XRN1 KDM1A FKBP4 DDX5 PTGES3 CUL3 NRBP1 RB1 DAXX NUP107 PPP1CC CDK8 DYNC1LI1 DYNC1LI2 NUP160 NUP85 RPS27 SEC13 NUP133 HDAC2 DYNLL1 RANGAP1 DYNLL2 DYNC1I2 PML NUP43 DYNC1I1 RANBP2 DYNC1H1 TAOK1 NUP37 FEN1 PRMT1 EIF4A2 EIF4A1 TJP1 CCNH RNMT POLR2A POLR2B POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 YBX1 CDK7 ERCC3 H2AC17 ERCC2 H2AC12 MNAT1 H2AC1 H2AC19 H2AC25 H2AC14 H2AC21 AKT2 TLR8 TLR7 AKT3 TLR3 AKT1 CSNK2A1 CSNK2A2 CSNK2B MASP1 MBL2 RPN2 MAPKAP1 C1QA RPN1 C1S PIK3R1 JAK2 CGAS LYN IRF7 H4C9 DHX9 XRCC6 XRCC5 H2AC20 STING1 CD28 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases CALM1 ATP10D ATP10B ATP10A ATP2C2 ATP2C1 ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 PDZD11 ATP2A3 ATP2A2 ATP2A1 SLN ATP1B3 ATP1B2 ATP1B1 ATP8A2 ATP8A1 CAMK2B ATP12A CAMK2D CAMK2A ATP1A4 ATP1A3 ATP1A2 ATP11C ATP11B ATP1A1 ATP11A SRI PLN CAMK2G ATP2B4 ATP2B3 ATP2B2 ATP2B1 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B ATP4A CUTC ATP7B ATP7A PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins PRKCQ PTK2 PRKCD CASP6 STK24 STK26 LMNB1 ACIN1 CASP7 DBNL GAS2 MAPT ADD1 PLEC ROCK1 CDH1 CASP8 CTNNB1 SPTAN1 BMX DSP APC TJP1 OCLN CASP3 DSG1 SATB1 PKP1 DSG2 VIM DSG3 TJP2 BIRC2 BCAP31 FNTA CLSPN GSN DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism MCCC2 MCCC1 PPM1K AUH IVD HIBCH OPLAH CYP24A1 BTD HLCS CBLIF CD320 CYP19A1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC BCKDK BCKDHA DBT BCKDHB DLD GSS CYP11A1 CYP2R1 SI CYP17A1 LCT CUBN AMN HGSNAT TBXAS1 NOTCH1 ECHS1 POMC IDH1 MGAT2 PMM2 MPI ST3GAL3 MOGS TPMT OMD ABCA3 DAG1 TALDO1 HSPG2 MAN1B1 PPP1R3C NHLRC1 DPAGT1 ALG8 SDC4 ALG9 SDC2 ALG6 HPRT1 SDC3 ALG2 ALG3 GNS ALG12 ALG1 MPDU1 RFT1 CHST14 GGT1 EXT1 EXT2 CYP11B2 B4GAT1 CYP21A2 SDC1 CYP2U1 GBE1 CYP1B1 KHK GYS2 GYS1 CHST6 GAA SFTPD ALDOB DHDDS DPM1 DPM2 DPM3 CHST3 GNE PAPSS2 GPC1 GPC3 IDUA GPC2 NEU1 HEXB NCAN GPC5 HEXA GPC4 BGN GPC6 DCN CTSA NUS1 BCAN ALG11 FMOD VCAN AGRN GLB1 HYAL1 NAGLU SRD5A3 GFPT1 GYG2 DOLK CSPG5 IDS GYG1 ACY1 NOTCH2 CSPG4 SLC35D1 EPM2A GUSB ARSB KERA NOTCH3 NOTCH4 UGT1A1 SLC26A2 SLC34A2 UGT1A4 POMT2 SEMA5A GALNT12 SPON2 SEMA5B ACACA SPON1 B3GALT6 THSD7B POMT1 G6PC3 ADAMTS4 ADAMTSL1 LFNG SFTPC OGN ADAMTS5 MTRR C1GALT1C1 AHCY ADAMTS2 MC2R ADAMTS3 ADAMTSL5 GALK1 MTR ADAMTSL4 MAT1A ABCD4 ADAMTS1 ADAMTSL3 B4GALT1 SFTPA2 ADAMTSL2 MUC12 MUC13 THSD7A SGSH LMBRD1 MUC15 ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 SLC37A4 FMO3 PGM1 POMGNT1 MUC3A MUC5AC MUC3B DCXR ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 B4GALT7 ADAMTS15 MUC1 ADAMTS14 ADAMTS13 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 GALT MUC7 MUC4 MUC6 PRELP GALNT3 MUC16 ACAN CYP7B1 MUC17 C1GALT1 CHSY1 CYP27A1 MUC19 TCN2 SSPOP MUC5B MUC20 MUC21 B3GAT3 LUM GALNS RPIA GALE UBA52 PC GALM ALG14 ALG13 ACAT1 UBB UBC RPS27A APRT CYP4F22 PNP ADA SFTA3 G6PC1 SFTPB SFTPA1 PAH CYP26B1 FDX1 CYP26C1 FDXR FDX2 MAOA THBS1 CYP27B1 CYP11B1 GCLC PCCA MMAA GCLM PCCB MMUT CSF2RB CSF2RA MMAB MMACHC MMADHC INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling IL11 CNTFR CNTF OSMR IL31RA IL31 OSM SOCS3 CTF1 JAK2 CLCF1 IL11RA LIF IL6 STAT1 TYK2 LIFR JAK1 STAT3 CRLF1 IL6R PTPN11 IL6ST CBL NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 SH2B3 SOCS2 ABL2 FLT3LG SOCS6 UBA52 SLA2 SLA UBB CSK PTPRJ FLT3 UBC RPS27A CBL DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN FGF10 EGF FGF2 FGF4 LAMA5 FGF7 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) CYP8B1 PTGS2 PTGES2 PTGES AKR1C3 CBR1 HPGDS PRXL2B PTGDS PTGES3 PTGR2 HPGD PTGS1 PTGIS TBXAS1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1C1 MUC1 MUC2 MUC12 MUC7 MUC13 MUC4 MUC6 MUC15 MUC16 MUC17 C1GALT1 MUC19 MUC5B MUCL1 MUC20 MUC21 MUC3A MUC5AC MUC3B RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2B GTF2F1 TAF7L GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TBP GTF2A1 GTF2A2 TAF9 TAF1L GTF2E1 GTF2E2 TAF15 TAF12 TAF13 TAF10 TAF11 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria GSDMD CYCS BAX GSDME DIABLO BAK1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism FADS1 ACSL1 ELOVL1 ELOVL5 ELOVL2 ELOVL3 ABCD1 FADS2 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM MMUT MMAA REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion INS PRKACG PRKACB KCNB1 SLC2A2 KCNS3 MARCKS SYT5 GLP1R SNAP25 VAMP2 STX1A GNGT1 ACSL4 CHRM3 ACSL3 FFAR1 RAP1A GNGT2 RAPGEF3 RAPGEF4 CACNA1D AHCYL1 PRKAR1B PRKAR2B CD36 PRKACA STXBP1 CACNA2D2 PRKCA PLCB3 PLCB1 PLCB2 SLC2A1 ADCY8 GNAQ ADRA2C GNG10 ADCY6 GNG3 PRKAR2A ADRA2A ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 CACNA1C GNG5 ITPR3 GNG4 GNG7 PRKAR1A GNG8 AKAP5 KCNJ11 KCNG2 ABCC8 CACNB2 CACNB3 IQGAP1 CACNA1A CACNA1E GNA14 GNA15 GNA11 GCG GNG12 GNG11 GNG13 GNB2 GNB1 GNAS GNB4 KCNC2 GNB3 GNB5 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis COQ6 COQ5 COQ4 HPDL COQ3 COQ2 COQ8B COQ8A PDSS2 PDSS1 STARD7 COQ9 COQ7 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism CTRB1 PRSS3 MTRR MTR LDLRAP1 CBLIF ABCD4 CUBN MMAA TCN1 AMN CD320 MMUT LMBRD1 ABCC1 LRP2 TCN2 MMAB PRSS1 MMACHC MMADHC CTRB2 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome ABCC9 KCNJ11 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG PLD3 PLD2 CDS2 PLD1 PLD4 PLD6 PGS1 PTPMT1 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 PRKCG KPNA2 ADCY9 PRKAR1B CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer GSK3A CHUK NR4A1 FOXO3 TSC2 MDM2 AKT1S1 PRR5 AKT2 GSK3B AKT3 BAD CASP9 AKT1 MLST8 PDPK1 MAPKAP1 FOXO6 CDKN1A FOXO4 RICTOR CDKN1B FOXO1 RPS6KB2 MTOR NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly H2AX MTA2 H3-3B H3C8 H2AJ H3C15 MTA1 HDAC1 MTA3 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 CHD5 H2BC3 IKZF1 UBE2I IKZF2 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 SUMO1 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 G6PC1 H2AC19 H2AC14 H2BC12L NR2C2 MBD3 H2BC26 H2BC21 GATAD2B GATAD2A H2BC17 H2BC12 H2BC13 H2BC14 FBP1 H2BC15 HDAC2 H2BC11 H4C9 CHD4 RBBP4 CHD3 RBBP7 H2AZ2 H2AC20 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance RAC1 PAK1 MAPK7 PAK3 PAK2 GAB1 GRIN2B TIAM1 PLCG1 ADAM10 GSK3B PIK3CD CLTCL1 PIK3CB PIP5K1C ARHGEF11 ARHGEF12 RHOB SHANK3 PIK3CA ARHGEF28 GIT1 COL4A2 COL4A1 COL6A2 COL4A4 CDC42 COL6A1 COL4A3 FYN COL9A1 COL6A3 PTPN11 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 AP2A1 RHOC AP2A2 ARHGEF7 PRKACG NGEF PRKACB ELOB AP2M1 ELOC NCBP1 NCBP2 PLXNB1 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B AP2S1 AP2B1 ACTB ARPC1B ARPC1A CFL1 WASL SDC2 GRIN1 MYH9 ARPC4 ARPC5 ARPC2 ARPC3 GRB7 ACTR3 ACTR2 RND1 PLXNA1 PLXND1 MYO10 MYL9 GPC1 MMP9 AGRN RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPS6KA6 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 EGFR RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 PSMD14 ARHGAP39 PSMD13 SEMA4D SLIT2 SRGAP3 LIMK2 PSMA7 SRGAP2 LIMK1 SRGAP1 RRAS ROBO1 MYH14 PSMB6 MYH10 PSMB7 PSMB4 PSMB5 DPYSL4 UBB DPYSL5 PSMB2 DPYSL3 PSMB3 UNC5C UBC UNC5D PSMB1 AGAP2 RPS27A DSCAML1 ADRM1 PLXNC1 SEMA6A SEM1 SEMA6D PSMC5 PSMC6 SEMA7A PSMC3 RAP1GAP PSMC4 PLXNA2 PSMC1 PSMC2 PLXNA3 PTPRC PTPRA PLXNB3 TREM2 SEMA3A NTN4 SEMA3E EIF4A3 CASC3 ABLIM1 ABLIM2 ABLIM3 MAGOH SEMA4A ARTN GFRA3 RGMB GFRA2 RGMA GFRA4 CD72 NRTN DSCAM DOK1 DOK2 TYROBP DOK4 DOK5 DOK6 CACNA1S RBM8A PRNP PSPN HJV PRKCA CRMP1 PDLIM7 UPF3B MAGOHB RNPS1 PITPNA ITGA5 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 LAMA1 NEO1 LAMB1 LAMC1 SH3KBP1 SRC MET SH3GL2 SHC3 SHC1 NRAS FARP2 MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 FRS2 PRKCQ SOS1 RHOA GFRA1 RPS6KA5 GDNF ITGB1 TRIO ITSN1 ARHGAP35 LDB1 PPP3CB DOCK1 EPHA1 EPHA2 KALRN UNC5A PAK4 CDK5 RPS6KA1 UNC5B CDK5R1 RBX1 RET VAV3 ITGAV PTK2 DAG1 HOXA2 ISL1 PFN1 VAV2 PFN2 GSPT2 GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH HSP90AB1 PABPC1 ROCK1 CXCR4 ROCK2 AKAP5 ZSWIM8 PAK6 PAK5 CAP2 MYO9B ACTG1 MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 EPHB6 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 RPS6KA4 EPHA3 ALCAM ITGA2B EPHA10 SCN11A EFNA5 DPYSL2 EFNA4 SCN9A EFNB2 NRCAM EFNB1 EPHB2 EFNB3 SCN1B EFNA1 RASA1 SCN1A EFNA3 ANK2 EFNA2 ANK3 ANK1 SHTN1 SCN10A SCN8A KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 NCAN ST8SIA4 SPTA1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN L1CAM ST8SIA2 KIF4B KIF4A ITGA10 CNTN1 EIF4G1 CNTN2 CD24 SCN2A CACNA1H MYL12A SCN2B NRP2 CNTNAP1 MYL12B CHL1 CACNA1G CACNA1I SCN5A SPTAN1 LYPLA2 SPTB MYH11 DNM1 DNM3 GAP43 DCX ABL1 NUMB SCN4A SCN4B ITGA9 SCN7A NCAM1 RANBP9 CLTB NFASC MYL6 PLXNA4 SEMA5A HSPA8 DNM2 DLG1 DLG3 CACNA1C DLG4 IRS2 RPS27 CACNB1 CACNB2 CACNB3 GAB2 CACNB4 ITGA2 ITGA1 SDCBP CLASP1 CLASP2 RELN DAB1 VLDLR SIAH2 SIAH1 FES CACNA1D PRKACA ERBB2 CSNK2A1 CSNK2A2 CSNK2B ITGB3 PIK3R3 PIK3R2 PIK3R1 GRB10 LYN RPS6KA3 RPS6KA2 YES1 TLN1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNGT1 PLCB3 PLCB1 PLCB2 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GRIK3 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSH ARSI ARSF ARSB ARSG STS ARSD ARSA SUMF2 SUMF1 ARSL ARSJ ARSK DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A VWF TPST2 TPST1 F9 F2 F8 F10 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RAD1 ATM RAD9B ATR RAD9A MRE11 BRCA1 BRCA2 KAT5 EXO1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 SEM1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RPA1 RPA2 PALB2 RAD50 RAD51 RPA3 RAD17 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism KYNU SLC36A4 KYAT3 HAAO AADAT SLC7A5 KYAT1 KMO TDO2 SLC3A2 IDO2 IDO1 ACMSD AFMID REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation KAT2B SIRT1 EP300 FOXO4 FOXO1 TXNIP TXN CREBBP FOXO3 SIRT3 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling TGFBR3 GIPC1 FGF2 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD3 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC34A1 SLC20A2 SLC20A1 SLC17A1 SLC34A3 SLC34A2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 VWF GP1BA GP9 GP1BB DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS CSPG5 CSPG4 NCAN BGN CHSY1 DCN BCAN VCAN DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER GTF2H1 ERCC4 GTF2H2 ERCC1 ERCC5 GTF2H3 UBA52 GTF2H4 GTF2H5 ERCC3 ERCC2 POLK POLE RFC5 RFC3 UBB RFC4 RFC1 UBC RFC2 RPS27A RBX1 PCNA POLD3 POLD4 POLD1 POLD2 PARP1 PARP2 CHD1L CUL4A RPA1 DDB1 RPA2 POLE4 CUL4B XPA RPA3 DDB2 POLE2 POLE3 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling INS PTPRF TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V0B IDE ATP6V1G1 ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INSR ATP6V0A2 ATP6V1H CTSD ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 PTPN1 ATP6V1F ATP6V1C2 ATP6V0A1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency GCN1 EIF2AK4 IMPACT CEBPB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 CEBPG RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 ASNS RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 ATF2 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 EIF2S3 RPL17 RPL19 EIF2S2 RPL35A EIF2S1 RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A ATF4 TRIB3 ATF3 DDIT3 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling SQSTM1 MAP2K1 MAP3K8 UBE2V1 NFKB2 HMGB1 UBE2N CASP8 TAB3 TAB2 TAB1 IRAK1 TRAF2 IL1A IL1B PELI1 PSMD8 IKBKB PSMD6 PSMD7 TRAF6 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 CHUK FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 APP IL1RN PSMA1 PSMA2 UBA52 TOLLIP PSMD12 IL1R2 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 MYD88 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 NKIRAS1 PSMB3 UBC NKIRAS2 IKBIP PSMB1 RPS27A ADRM1 NFKB1 SEM1 IRAK4 NFKBIA RBX1 PSMC5 PSMC6 PSMC3 PSMC4 LRRC14 PSMC1 USP14 PSMC2 NLRX1 MAP3K3 PELI3 NFKBIB PELI2 NLRC5 NOD1 NOD2 AGER USP18 IRAK2 S100A12 N4BP1 S100B TNIP2 SAA1 IRAK3 TP53 TIFA ALPK1 MAP2K4 MAP2K6 IL1R1 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 GAB1 MET HGF PTPN11 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death CASP8 TICAM1 TLR3 RIPK3 RIPK1 FADD LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se NNMT CTH GNMT AHCY CBS SCLY HNMT MAT1A DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation PRKCB STX4 PRKCG PRKCA STXBP3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction HSD17B6 GUCY2F HSD17B1 NMT1 LRP1 CALM1 RDH12 LRP8 OPN1LW AWAT2 GPC1 GPC3 APOA2 GPC2 BCO2 APOA4 SLC24A1 RHO GPC5 BCO1 SAG GPC4 CNGA1 RCVRN GNAT1 GPC6 CNGB1 SDR9C7 AGRN METAP1 METAP2 LPL CAMKMT LDLR GPIHBP1 RGS9BP MYO7A GNGT1 OPN1MW APOE APOC3 APOC2 TTR ABCA4 GRK1 GUCA1B GUCA1A GUCA1C GRK7 PLB1 PRKCQ APOM NMT2 AKR1C3 PRKCA DHRS3 HSPG2 PDE6B SDC4 PDE6A DHRS9 SDC2 RDH11 PDE6G SDC3 LRP10 RDH10 RDH16 RPE65 RDH5 PPEF1 AKR1B10 LRP12 OPN1SW STRA6 APOB SDC1 RDH8 CYP4V2 LRAT RLBP1 APOA1 AKR1C1 AKR1C4 RBP4 RBP2 LRP2 RBP3 GNB1 CLPS RBP1 FNTA RETSAT FNTB GUCY2D PNLIP AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS TGFA SOS1 EGF EREG BTC AREG EPGN HBEGF EGFR NRAS BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SLC35C1 ALG5 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL FUOM ALG10B NEU2 NEU3 ALG14 NEU4 ALG13 DHRSX GMDS SLC17A5 AMDHD2 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA NUS1 ALG11 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 GLB1 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ST6GALNAC2 MVD ST3GAL4 GMPPB PMM1 GMPPA ST3GAL1 PMM2 MPI ST3GAL2 ST3GAL3 ST6GAL1 ST6GALNAC3 ST6GALNAC4 DPAGT1 ALG8 ALG9 HK1 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 ST3GAL6 ALG10 ST6GALNAC6 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU UBE2D1 RPL26L1 UBB UBC RPS27A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 UBE2D2 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 ASCC2 RPS10 ASCC3 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A ZNF598 RPS3A UBE2D3 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha SLC27A1 CCNC PPARGC1B CYP1A1 AHRR MED9 CDK19 ACADM MED16 MED15 MED17 MED12 MED14 MED13 MED10 UGT1A9 HMGCS1 SREBF2 MTF1 MED27 MED26 ESRRA G0S2 FHL2 MED23 MED25 FADS1 MED24 TNFRSF21 MED20 FDFT1 CDK8 ABCB4 RXRB NFYA NFYB NFYC ANKRD1 SP1 GRHL1 HDAC3 SMARCD3 ACSL1 CHD9 PEX11A CPT2 NPAS2 SIN3A HELZ2 TGS1 EP300 TBL1X PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 NR1H4 TBL1XR1 PLIN2 CARM1 CYP7A1 BMAL1 CLOCK TXNRD1 ALAS1 TIAM2 SULT2A1 HMGCS2 APOA2 APOA5 MED8 ANGPTL4 MED4 MED6 MED7 ARNT2 ABCA1 RGL1 MED30 NR1H3 MED31 FABP1 NR1H2 RORA CPT1A RXRA PPARG AGT PPARA CD36 MED19 MED18 THRAP3 MED11 MED29 FAM120B MED28 NCOR2 MED22 MED21 GPS2 TRIB3 ARNT CYP4A11 MED13L ME1 NCOA3 GLIPR1 NRF1 AHR FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 FBXL7 PSMC4 PSMC1 PSMC2 FBXL18 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex BCL7A PBRM1 BCL7C BCL7B SMARCB1 SMARCD1 SMARCD2 PHF10 SMARCA2 ACTB SMARCA4 SMARCC1 SMARCD3 SMARCC2 ACTL6A ARID2 SMARCE1 BRD7 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia F9 F8 F10 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 PLK1 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CCNB1 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEK2 BUB1B CDC20 PTTG1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC CD320 TCN2 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense CASP4 CALM1 GBP1 GBP6 UBA52 UBE2D2 CALM3 CALM2 GBP2 UBB GBP4 UBC RPS27A DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response ATM H2AX HERC2 UBA52 CHEK2 UBB UBC RPS27A MAPK8 H2BC9 H3-4 PIAS4 H2BC8 H2BC5 ABL1 H2BC3 UBE2I H2BC1 BRCC3 SUMO1 KPNA2 TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 RNF8 MRE11 NSD2 BRCA1 KAT5 TP53 NBN H2BC12L SMARCA5 PPP5C H2BC26 UBE2V2 BAP1 UBXN1 H2BC21 BAZ1B APBB1 UBE2N KDM4A MDC1 H2BC17 EYA1 EYA2 H2BC12 H2BC13 EYA3 H2BC14 EYA4 H2BC15 H2BC11 BARD1 H4C9 KDM4B RAD50 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis ACD H2AX ATR SUN2 LMNB1 SYCP2 SYCP1 SYNE2 SYNE1 SUN1 TEX12 TERF1 TERF2 SMC1B H2AJ SYCE3 SYCE2 POT1 SYCE1 TERF2IP REC8 STAG3 SYCP3 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 UBE2I H2BC1 H2AB1 SMC3 H2AC8 H2AC6 H2AC7 BRCA1 H2AC19 H2AC14 H2BC12L RAD21 H2BC26 STAG1 H2BC21 STAG2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 FKBP6 SMC1A H2BC11 H4C9 TINF2 HSPA2 H2AZ2 H2AC20 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization CADM1 PVR NECTIN4 NECTIN3 NECTIN2 NECTIN1 CADM3 CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis GATA4 KAT5 ISL1 KAT2A EOMES GATA6 TBXT WDR5 CTNNB1 NKX2-5 HAND2 FOXO4 SRF HEY1 MEF2C MESP1 TBX20 HEY2 SMYD1 LEF1 TBX1 MYOCD HAND1 LDB1 SMAD1 SMAD4 TBX5 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition MCM6 MCM2 CCNB1 CDK1 ORC5 ORC4 ORC6 ORC1 MCM8 ORC3 CCNA2 ORC2 CCNA1 RB1 CDKN1A CDKN1B CCND1 E2F1 SKP2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 CDC6 PPP2R1B PPP2R1A PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 PPP2CA PPP2CB PSMA5 PSMA6 PSMA3 RRM2 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 PRIM2 CUL1 PRIM1 POLA1 PSMA7 POLA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 MCM10 MAX PSMC5 DBF4 PSMC6 PSMC3 PSMC4 PTK6 PSMC1 RPA4 LIN54 PSMC2 CKS1B LIN52 LIN37 HDAC1 LIN9 CABLES1 WEE1 CDC7 CCNH CDK7 MNAT1 POLE RBL2 RBL1 AKT2 MYC AKT3 AKT1 FBXO5 PCNA DHFR E2F4 TK1 TYMS E2F5 PPP2R3B E2F6 RPA1 RPA2 CDC45 POLE4 MCM7 RPA3 MCM3 POLE2 MCM4 POLE3 MCM5 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance AMN HDLBP APOA1 CUBN TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes AURKA SFN BAX ZNF385A CDC25C PCBP4 CCNB1 CDK1 GADD45A CCNA2 CCNA1 PRMT1 CPAP CDKN1A CDKN1B PLK3 E2F1 TFDP1 CCNE2 CNOT6L TFDP2 CCNE1 CDK2 BTG2 CNOT4 CNOT6 CNOT7 TNKS1BP1 RGCC CNOT1 TP53 CNOT2 CNOT3 NPM1 CNOT8 PLAGL1 CNOT9 RBL2 RBL1 PLK2 EP300 ARID3A PCNA CNOT10 E2F4 CNOT11 CARM1 E2F7 E2F8 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling TBK1 TNF TNFRSF1A RBCK1 USP2 IKBKE OPTN TRADD CASP8 TRAF2 RNF31 MIB2 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 BIRC2 USP4 BIRC3 XIAP CYLD OTUD1 RIPK1 FADD RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions MT1E CSRP1 SNCB MT2A MT1A MTF1 MT1M MT1F MT1G MT1X MT1H MT4 MT1B MT3 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TNFSF12 LTA TRAF2 LTB LTBR TNFRSF11A TNFSF11 MAP3K14 TRAF3 BIRC2 BIRC3 TNFRSF13C TNFRSF12A CD40LG TNFSF13B ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin INHBB FST INHBA FSTL3 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion PRKAR2B PRKACA PRKACG PRKACB KCNB1 ADCY8 GNG10 ADCY6 GNG3 PRKAR2A ITPR1 ADCY5 GNG2 KCNS3 ITPR2 GNG5 ITPR3 GNG4 GNG7 GNG8 PRKAR1A AKAP5 KCNG2 GLP1R IQGAP1 GNGT1 RAP1A GNGT2 GCG GNG12 GNG11 GNG13 GNB2 RAPGEF3 RAPGEF4 GNB1 GNAS GNB4 KCNC2 GNB3 GNB5 PRKAR1B PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination UBA1 UBE2K UBE2C UBA52 UBE2E1 UBE2D1 UBE2Q2 CDC73 RNF152 SHPRH HLA-B RRAGA BCL10 UBE2S USP7 PEX2 HLA-A RNF40 UBE2R2 RNF144A SKIC8 SELENOS WAC UBE2J2 CTR9 RTF1 UBB TMEM129 HLTF UBC LEO1 PEX10 RPS27A PEX12 PEX13 DERL1 PEX14 PAF1 RNF181 USP5 H2BC9 UBE2D2 H2BC8 H2BC5 H2BC3 H2BC1 UBE2G1 UBE2B UBE2G2 RAD18 CDC34 VCP UBE2Z UBE2E3 OTULIN UBE2V2 USP9X UBE2L3 UBA6 UBE2N UCHL3 H2BC17 H2BC12 H2BC13 PCNA H2BC14 RNF20 H2BC15 H2BC11 UBE2H UBE2D3 PRKDC UBE2A UBE2T UBE2W SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea KCNMB1 KCNMA1 EZR SPTBN1 RDX MSN CLIC5 RIPOR2 SNAP25 CIB2 PJVK ESPN EPS8 SPTAN1 PLS1 TPRN TMC1 VAMP2 MYO7A STX1A TMC2 MYO3B MYO3A KCNQ4 FSCN2 TWF2 PCDH15 PCLO USH1C CAPZB ESPNL BSN EPB41L3 SYP CABP2 CDH23 CACNA1D XIRP2 CABP1 EPS8L2 LRRC52 OTOF GRXCR1 CASK SLC17A8 GRXCR2 CAPZA1 WHRN CAPZA2 LHFPL5 TMIE USH1G STRC EPB41L1 MYO15A CACNA2D2 SYN1 RAB3A TWF1 MYH9 CACNB2 ATP2B1 DNAJC5 MYO1C ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation FBLN2 FBLN5 FURIN TGFB2 MFAP5 ITGAV MFAP4 FBN1 VTN MFAP3 MFAP2 LTBP4 LTBP2 LTBP3 LOX LOXL3 LOXL4 LTBP1 LOXL1 ITGB8 TGFB1 LOXL2 ITGB6 TGFB3 ITGB5 BMP4 ITGA8 GDF5 ELN ITGB1 ITGB3 ITGA5 BMP7 BMP2 EFEMP2 EFEMP1 BMP10 FBN2 FBN3 FBLN1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling CHUK PPP2CA PPP2CB FBXW11 JUN UBA52 CUL1 RIPK2 RPS6KA1 FOS ATF1 UBB UBC IL25 MEF2A RPS27A DUSP4 DUSP3 NFKB1 VRK3 MAPK9 DUSP6 MAPK8 IL17RE DUSP7 MAPK7 IL17RB ELK1 MAPK10 NOD1 IL17C NOD2 IRAK2 MAPK1 MAPK3 TNIP2 MAP2K1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 ATF2 IL17RC RPS6KA5 IL17RA UBE2N TAB3 TAB2 TAB1 IRAK1 PPP2R5D MEF2C RPS6KA3 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG IL17F BTRC MAP2K7 IL17A MAP3K7 MAP2K6 SKP1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2AC6 H2AC7 ACD H2AX H2AC19 H2AC14 H2BC12L TERF1 TERF2 H2AJ POT1 H2BC26 TERF2IP H2BC21 OGG1 NTHL1 TDG H2BC17 MBD4 H2BC12 SMUG1 H2BC13 NEIL3 H2BC14 NEIL2 H2BC15 NEIL1 H2BC9 H3-4 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 TINF2 H2AB1 H2AZ2 H2AC20 H2AC8 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence ATM ACD H2AX HMGA2 H1-1 H1-0 H1-3 H1-2 HMGA1 H1-5 H1-4 LMNB1 CABIN1 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 TERF2IP HIRA UBN1 RB1 CDKN1A CDKN1B H2BC9 H3-4 H2BC8 H2BC5 H2BC3 H2BC1 CCNE2 CCNE1 CDK2 H2AB1 H2AC8 H2AC6 H2AC7 MRE11 KAT5 TP53 NBN H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H4C9 TINF2 ASF1A RAD50 EP400 H2AZ2 H2AC20 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking WNT8A WNT8B WNT6 WNT11 WLS VPS29 WNT1 VPS35 WNT2 WNT3 TMED5 WNT4 WNT10B VPS26A SNX3 WNT10A WNT5B WNT2B WNT3A PORCN WNT7B WNT7A WNT5A WNT9B WNT9A WNT16 RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling DOK1 DOK2 DOK4 DOK5 SOS1 PRKACA DOK6 PRKACG PSPN PRKACB PRKCA PDLIM7 PIK3CD IRS2 PIK3CB GFRA1 GDNF MAPK7 RAP1GAP GAB2 SHANK3 PIK3R3 PIK3R2 PIK3R1 PIK3CA SHC3 SHC1 GRB7 GRB10 GAB1 ARTN PLCG1 GFRA3 GFRA2 FRS2 GFRA4 RET PTPN11 NRTN BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) ALOX5 ALOX12 HPGD PTGR1 ALOX5AP LTC4S PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling RAC1 VAV1 SRC PIP5K1A PIP5K1B TGFA MET EREG BTC EPGN HBEGF NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 CD86 EGF CD80 FRS2 FLT3 AREG PPP2R1B PPP2R1A CD19 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF IRS2 PIK3CD FGF1 FGF2 PIK3CB FGF3 PIK3CG NRG1 FGF4 FGF6 PIP5K1C FGF7 FGF9 FGF20 FGF23 PPP2R5E FGF22 GAB2 IRAK1 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A PIK3CA FGF10 PPP2R5D PPP2R5C LCK FYN TRAF6 RHOG PTPN11 PPP2CA PPP2CB INS PIP4K2A MYD88 PIP4K2B PDGFRA PDGFRB TRAT1 PDGFB IRAK4 NTRK3 PIK3AP1 IER3 FLT3LG KIT IL33 RAC2 IL1RL1 ESR1 ESR2 AKT1 ERBB2 STRN PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR CD28 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes TMEM219 CHM ZNF420 TNFRSF10B ATM TNFRSF10A TP53I3 TNFRSF10C AIFM2 FAS PERP BNIP3L TNFRSF10D BCL6 TP53AIP1 BAX TP53 CASP6 PRELID3A CASP2 PPP1R13B IGFBP3 TP53BP2 BID APAF1 NDRG1 RABGGTB RABGGTA CASP1 BBC3 TP63 PRELID1 STEAP3 CREBBP CASP10 TP53INP1 NLRC4 CRADD BIRC5 TP73 TRIAP1 PMAIP1 PIDD1 BCL2L14 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF9 FGF20 FGF23 FGF22 PIK3R1 PIK3CA FGF10 GAB1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 DISEASE%REACTOME%R-HSA-1643685.19 Disease DKK1 DKK2 TFG EZH2 DKK4 H2AX ASH2L CD3G MAGT1 F5 F8 RAC1 JAK1 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 LRP6 VAV1 H2AJ SEC31A DERL3 DERL1 DERL2 H3C15 OS9 RICTOR PAK2 BRD4 KLC1 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 CD86 TUSC3 CD80 H2AB1 NEK2 CYP19A1 H2AC8 H2AC6 H2AC7 TMEM258 VCP SEL1L OST4 NFKB2 OSTC STT3A STT3B RNF185 PRR5 GSK3B PIK3CD DPY30 PIK3CB PIK3CG H2BC26 H2BC21 MLST8 WDR5 YWHAG EED PDPK1 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 PIK3CA DAD1 LCK H2BC11 RNF5 CDC42 ERLEC1 RBBP4 RBBP5 FYN CSK RBBP7 TCF7L2 H2AZ2 PTPN11 MTOR TNRC6C CD4 PTPN6 PDCD1 CCNK CCNT2 ELL CCNT1 GTF2B TAF7L ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H TBP NCBP1 NCBP2 GTF2A1 GTF2A2 CTDP1 TAF9 SUPT4H1 TAF1L GTF2E1 GTF2E2 ABCD1 TAF15 TAF12 ETV6 TAF13 FIP1L1 TAF10 TAF11 BIN2 ELOA2 KDR SSRP1 CDK9 TAF8 TCEA1 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GJA1 ACTB TP53 LIG4 XRCC4 ATIC NUP205 ARID4A POM121 ARID4B FNTA NUP188 FNTB PSIP1 IL1R1 AAAS POM121C SAP30 BRMS1 NUP42 IFNAR1 NUP62 TPR PHF21A CD79B BANF1 NUP88 CD79A RAE1 SUDS3 KPNA1 RCOR1 IGHM NUP214 BLNK NDC1 NUP210 HMG20B JAK3 NUP155 HMGA1 IFNGR1 NUP153 IFNGR2 NUP93 SIGMAR1 TYK2 NUP50 IGHD NUP35 SAP30L NUP54 SLC25A5 S1PR1 SLC25A4 SAP18 CRBN SLC25A6 STAT2 CPSF1 CSTF3 CPSF3 CSTF2 CPSF2 CSTF2T WDR33 NUDT21 PCF11 CLP1 CSTF1 PAPOLA RPL4 SYMPK RPL5 SLC35D1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 UGT1A1 RPL6 RPL7 IPO5 RPS15 RPS14 RPS17 UGT1A4 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 KPNA7 RPL35 KPNA4 RPL38 KPNA5 RPL37 RPS11 KPNA2 KPNA3 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 SFTPC RPS8 RPL23 RPS5 RPL22 RPS6 FGFR1 RPSA RPL9P9 SLC12A3 RPL24 SFTPA2 RPL27 RPL26 SLC12A1 RPL29 SLC12A6 RPL28 KPNB1 RPS4Y2 RPS4Y1 RPL39L CPSF4 RPL41 TGFB1 MLKL BAD EIF2AK2 CASP9 ISG15 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR GRSF1 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X RPL7A RPLP2 HSP90AA1 PARP1 RPL13A RPS3A DNAJC3 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 GBP1 RPL19 RPL35A RPL23A RPL22L1 FAU RAN RPL26L1 CDC73 HSPA1A ALG14 ALG13 HLA-B SKIC8 RUNX1 CTR9 RTF1 LEO1 PAF1 FASN RNASEK PROS1 RPS6KB2 CLDN1 MRC1 EMC4 CD33 HSPA5 CD300A TIMD4 MERTK EIF4A3 MRAS AXL TYRO3 SHOC2 MAPRE3 GAS6 LY6E CDC40 SRRM1 CYP4F22 SRSF2 SRSF3 SRSF4 SRSF5 F11 SRSF6 SRSF7 SRSF9 SFTPB SRSF1 U2AF1 U2AF1L4 IRF4 U2AF2 DHX38 SRSF11 ALYREF RNPS1 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 FN1 VTN AP1G1 PACS1 AP1S2 AP1B1 AP1S1 AP1S3 HLA-A ANO10 B2M AP1M2 AP1M1 UBE2D2 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 UBE2V1 V1-11 IGKV2D-30 V1-16 NMT2 V1-13 IGHV4-59 NRG2 IGHV1-69 NRG3 NRG4 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 BCL2A1 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 UBE2N TAB3 TAB2 TAB1 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 CFTR IGKV3D-20 V5-6 TRAF6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC RCC1 NMT1 IGLV3-21 IGKV1-39 CCR5 IGKV1-33 RANBP1 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 YWHAH YWHAZ KIT RAC2 HDAC1 S100A9 S100A8 ECHS1 MARK3 POMC CAV1 PROC IFNA5 IFNA4 IFNA7 IFNA6 SLC5A5 IFNA1 IFNA2 IFNA8 IFIH1 RNF135 TRIM25 IFNA21 IFNA14 IFNA16 VAV3 IFNA17 SIKE1 TPMT MAVS IFNA10 RIGI SRPK2 SRPK1 VAV2 CX3CR1 RAB5B IMPDH1 RAB5C IGF1R NCL IMPDH2 RAB5A HPRT1 SLC4A1 HSP90AB1 ROCK1 RHAG ROCK2 ACTG1 CPSF7 CDC37 VIM HNRNPC RBMX FURIN TGFBR1 TGFBR2 RPTOR TSC2 AKT1S1 PGK1 EIF4E EIF4G1 ACY1 STX1B SNAP25 SYT2 SV2C SYT1 SV2B SV2A VAMP1 VAMP2 STX1A APC SLC34A3 SLC34A2 TPM4 SLC34A1 TPM3 SEC23A PTPN12 POMT2 SAR1B SEMA5A GALNT12 SPON2 ACACA SEMA5B SPON1 THSD7B SCAP POMT1 ADAMTS4 ADAMTSL1 LFNG ADAMTS5 SEC24B C1GALT1C1 SEC24A ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 SP1 MUC12 MUC13 THSD7A SEC24D MUC15 SEC24C ADAMTS8 LARGE1 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 POMGNT1 MUC3A MUC5AC MUC3B TRADD ADAMTS20 HMGB1 B3GLCT CFP CASP8 THBS2 ADAMTS12 CASP4 THSD1 THSD4 ADAMTS10 CASP1 ADAMTS16 ADAMTS15 MUC1 PDCD6IP ADAMTS14 RIPK3 ADAMTS13 IL18 MUC2 TRAF2 ADAMTS19 IL1A ADAMTS18 IL1B ADAMTS17 MUC7 CHMP4C MUC4 CHMP4B MUC6 GALNT3 CHMP3 MUC16 CHMP4A MUC17 CHMP6 C1GALT1 CHMP7 MUC19 SSPOP MUC5B MUC20 MUC21 RIPK1 FADD GSDMD GZMB ITCH CHMP2B CHMP2A GSDME SLC22A5 WDR48 F2 AHCYL1 SFTA3 PRKACA ABCC9 ATP1B3 ATP1B2 ATP1B1 SFTPA1 CAMK2B CAMK2D CAMK2A ATP1A4 ITPR1 ATP1A3 ITPR2 ATP1A2 ITPR3 ATP1A1 CAMK2G KCNJ11 FXYD4 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 PCCA MMAA PCCB MMUT MAP2K4 ZAP70 TXN MMAB MMACHC MAP2K7 MMADHC MCCC2 MCCC1 PPM1K AUH IVD HIBCH AMER1 IL6 MDM2 TPST2 TPST1 F9 CYP24A1 CEBPB MAPK9 BTD MAPK8 HLCS CDKN2A IFNB1 CBLIF NTRK2 F10 BDNF GAB1 CD320 GGCX FRS3 NTF4 NTF3 PLCG1 EGF ELAVL1 C4BPA AREG BCL2L1 C4BPB CLU EEF1G SERPING1 EEF1A1 EEF2 JAG2 JAG1 ADAM10 CD19 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 GEMIN2 SNRPD2 SNRPD1 SNRPD3 SNRPG GEMIN4 GEMIN5 SNRPE GEMIN6 GEMIN7 SNRPF GEMIN8 SNRPB DDX20 SMN2 ABCC8 C3 C4A C4B_2 GUCY2C CYP2R1 SI LCT H2BC18 BECN1 UVRAG SLC35A3 MAP1LC3B ISCU SLC1A1 SLC2A9 SLC3A1 SLC1A3 SLC3A2 SLC6A20 SLC6A19 SLC36A2 SLC6A14 ACOT2 SLC7A7 SLC7A9 ST6GALNAC2 PRKCSH ZDHHC20 NOS2 ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 GOLGA7 ST3GAL1 ST3GAL2 ST3GAL3 GBP6 ST6GAL1 LARP1 EDEM2 MOGS GRPEL1 HYOU1 ZDHHC11 MED19 MGAT4C MED18 ZDHHC9 PQBP1 MGAT4A MED11 MGAT4B MED29 MAN1B1 MED28 ST6GALNAC3 MED22 ST6GALNAC4 MED21 ATL2 SRRT VPS33A VPS33B ZCRB1 SNRNP200 CORO1A G3BP1 G3BP2 CAMK4 FUS NACA ISY1 IL10 BCAS2 CD163 PLK2 CTNNBL1 RHBDF2 PRCC HNRNPA1 MYH9 HNRNPA0 HNRNPA3 GPKOW CNBP CDC5L RBPJ KDELR1 CCAR1 CD2BP2 PCBP1 PCBP2 RBM10 MED13L BST2 CALM3 RETREG1 CALM2 SUGP1 DHX15 DHX16 UFD1 ARIH1 SFTPD BCAP31 TXNIP PEX19 NLRP12 HNRNPA2B1 IL17F IL17A WBP11 HNRNPUL1 DNAJB11 PPIE PPIH PPIG PPIB RTN3 DDX3X DDX46 DDX42 SFN RBM17 SUN2 DYNLT1 BUD31 MMP9 SFPQ RBM22 DDX23 RRBP1 SMNDC1 U2SURP HNRNPR VPS39 VPS18 MED9 ATG14 MAP1B VPS11 VPS16 BTF3 CDK19 HNRNPL HNRNPM HNRNPK NPLOC4 HNRNPF HNRNPD CLINT1 MED16 SF3B4 MED15 SF3B5 MED17 SF3B2 SF3B3 MED12 SF3B6 MED14 SF3B1 MED13 SF3A3 HEY1 SF3A1 SF3A2 MED10 XAB2 PHF5A HEY2 HSPA1B CLEC4M AUP1 IPO7 CLEC5A TXNL4A SNRPN BAG2 CHERP P4HA1 MED27 P4HA2 MED26 P4HA3 RCAN3 EIF4G3 MED23 EIF4G2 MED25 EIF4E3 MED24 DUSP16 PTBP1 MED20 PLRG1 SNRPA1 DNAJC8 CEBPD PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 DNAJA2 VPS41 EGFR NPIPB3 VPS45 PPIL3 PPIL4 PPIL6 SRRM2 AQR HLA-H HLA-C HLA-F CRNKL1 HLA-G MBD3 HLA-E NMI PRPF19 CHMP1A HHAT TOMM70 IL17RC IL17RA TLR1 HNRNPH1 GATAD2B HNRNPH2 GATAD2A TLR6 TLR2 SPCS3 SPCS2 SPCS1 CWC25 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 CBX1 CWC15 DNAJC10 ELAVL2 RBM5 OAS2 LTF GBP2 GBP4 NHERF4 KMT2D FOXO6 FOXO4 FOXO1 MED30 MED31 S100A1 CD36 G6PC1 TIRAP PTEN ITGA4 CYP27B1 CYP11B1 GCLC GCLM CCNC TRIM28 TGFA ZMYM2 SNW1 CTSL NPM1 GCK MAMLD1 IRAK1 CHD4 CHD3 YWHAQ CYP17A1 MTA2 REST KRAS MAML2 MAML1 HGSNAT NAPEPLD JUNB MED8 MED4 MED6 MED7 CARS1 NEDD4L NCOR2 KAT2B KAT2A TAL1 GPS2 FGFR3 SYVN1 ITGA2B OPN1LW NRBP1 NOTCH2 NOTCH3 NOTCH4 ABL1 CDK8 MC2R SIN3A FMO3 HDAC5 HDAC2 HDAC8 HDAC9 HDAC6 HDAC7 TXNRD1 PML HDAC10 HDAC11 TWIST1 PRMT1 GP1BA SMAD2 SMAD4 SMAD3 SLC17A8 ESR2 NR4A1 YBX1 PAH AXIN1 THBS1 ERBB2 HES1 PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 PORCN ARRB2 RAP1B JAK2 BRAP WDCP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 VCL MAP3K11 BAG4 F12 KLKB1 OPLAH SLC40A1 HEPH SLC11A2 ATP6V1H CP ZBP1 TBK1 IRF3 SLC9A6 SLC9A9 BCKDK BCKDHA DBT BCKDHB DLD HDLBP AP2A1 AP2A2 PRKACG PRKACB IL10RA AP2M1 CUBN AMN PDGFB AP2S1 ABCA1 AP2B1 P4HB IDH1 ENO1 OMD TALDO1 HSPG2 PPP1R3C NHLRC1 SDC4 SDC2 SDC3 GNS CHST14 EXT1 EXT2 B4GAT1 SDC1 GBE1 KHK GYS2 GYS1 CHST6 GAA ALDOB CHST3 PAPSS2 PAPSS1 GPC1 GPC3 SLC17A5 GOLGB1 GPC2 GPC5 GPC4 GPC6 ALG11 FMOD AGRN NAGLU GYG2 GYG1 EPM2A KERA SLC26A2 DCTN1 TKFC GCKR ABCA12 SLC4A4 BSG SLC39A4 B3GALT6 SLCO2A1 SLC27A4 G6PC3 ABCB6 ABCB4 SLC5A2 OGN SLCO1B1 SLCO1B3 SLC33A1 SLC6A5 GALK1 SLC26A4 SLC26A3 ABCD4 SLC6A2 B4GALT1 SLC22A12 SLC2A10 SLC2A1 ABCC6 LMBRD1 SGSH SLC29A3 HK1 SLC24A4 SLC20A2 ABCB11 SLC35A2 SLC16A1 SLC24A5 SLC37A4 PGM1 DCXR B4GALT7 GALT PRELP ACAN CHSY1 B3GAT3 LUM GALNS RPIA GALE PC GALM TICAM1 TRAF3 CD14 IKBKE FLT3LG HNRNPU MTA1 MTA3 APRT PNP PRF1 FOXM1 ADA ICOS ABCG8 ZC3HC1 ABCG5 GSK3A PARP6 PARP4 GALNT1 PARP16 PARP9 PARP14 PARP8 PARP10 PRKG2 CYP26B1 CYP26C1 MAOA ALK EML4 RDH5 PPM1B HIP1 PRKAR1A BCL11A EIF2AK3 STRN BIRC6 OGG1 NTHL1 NEIL3 NEIL1 TSG101 VPS4B VPS4A MVB12B MVB12A VPS36 VTA1 VPS37C VPS37D VPS37A VPS37B SNF8 UBAP1 CSF2RB VPS25 CSF2RA VPS28 CHMP5 TUFM CSNK1A1 OPN1SW CD209 ITGB1 CYFIP1 CYP11A1 RHOG ELMO2 DOCK2 DOCK1 RAB7A ERBIN TBXAS1 PPP1CB PPP1CA ABCA4 PMM2 MPI PTK2 ABCA3 DAG1 DPAGT1 ALG8 ALG9 PRKAR2A ALG6 ALG2 ALG3 NRP1 ALG12 ALG1 MPDU1 RFT1 PABPC1 CXCR4 MYO9B CYP11B2 CYP21A2 NCK1 SLC35C1 DHDDS DPM1 DPM2 DPM3 GNE NEU1 CTSA NUS1 SLC35A1 SRD5A3 GFPT1 DOLK TMPRSS2 ACE2 HAVCR1 ELK1 EREG BTC EPGN HBEGF SQSTM1 ARF1 HSPA8 MTRR AHCY MTR MAT1A COMT KLB IRS1 PIK3R4 IRS2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 ABCC2 CUX1 FGFR1OP2 IL6R MYO18A CPSF6 KEAP1 UBE2L6 HERC5 RNF213 ATG7 PDGFRB TRAT1 NTRK3 PIK3AP1 TRIM4 TTR KIF5B LMO7 CUL5 UBA7 UBA6 UBA5 UBR4 UBA3 UBA1 VHL PPFIBP1 HGF PATJ PALS1 CRB3 GSS CTBP2 CTBP1 NCKAP1 BRK1 CYBA BCR NOXO1 NCKAP1L WASF1 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX1 C1QBP DNMT3B DNMT3A PRIM2 DNMT1 PRIM1 POLA1 POLA2 MCL1 PDGFRA SLC2A2 SLC5A1 SLC6A3 PSENEN PSEN2 IL22 PSEN1 APH1A NCSTN APH1B HES5 HEYL SLC67A1 HCK CD8B ELMO1 OPN1MW UPK1A EPCAM CYFIP2 WIPF1 WIPF2 WIPF3 GNAT3 C3AR1 ENTPD1 ENTPD5 ADCY9 PRKAR1B BTK MEFV PRKAR2B PLCG2 MYO5A ARPC1B ARPC1A WASL CTSG SYK GNAI3 ADCY4 WAS ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 NT5E PYCARD IGHG3 IGHG4 IGHG1 CYSLTR1 IGHG2 CYSLTR2 GGT1 DPEP2 DPEP1 GNAZ NCKIPSD DVL1 DVL2 DVL3 NLRP3 GGT5 ARPC4 ARPC5 ARPC2 ARPC3 PSTPIP1 FCGR3A ACTR3 ACTR2 FGR MYH2 ADORA2B FCGR1A WASF3 MYO10 P2RX7 P2RX4 FCGR2A MYO1C SUGT1 TRIM27 TNKS TNKS2 LIG1 CD9 NRG1 CYP7B1 PSMD8 IKBKB PSMD6 CYP27A1 TCN2 PSMD7 PSMD2 DUSP10 PSMD3 PSMD1 IKBKG BTRC DUSP8 MAP3K7 DUSP9 SKP1 CHUK PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RIPK2 PSMA7 MYD88 RELA SLC24A1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 IRAK4 SEM1 NFKBIA DUSP6 PSMC5 DUSP7 PSMC6 TLR10 PSMC3 TLR5 PSMC4 PSMC1 PSMC2 NFKBIB NOD1 NOD2 HDAC4 IRAK2 UBE2I NR3C1 ESR1 TENT4A KIAA1549 MPRIP TRIM24 AGTRAP AP3B1 SND1 SUMO1 ESRP1 AKAP9 KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 MRE11 LMNA BRCA1 AGK QKI BRCA2 CLCN6 KAT5 FAM131B EXO1 AGGF1 NBN TOPBP1 RFC5 RFC3 RMI2 RFC4 RFC2 RMI1 TOP3A HUS1 RAD51B RAD51D RAD51C DNA2 RHNO1 BLM RAD51AP1 LRAT WRN BRIP1 RBBP8 ATRIP BARD1 XRCC2 RBP4 RPA1 RPA2 PALB2 RAD50 RAD51 RBP1 RPA3 RAD17 RAD1 ATM RAD9B ATR RAD9A RDH12 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 SH3GL3 SH3KBP1 SRC CTNND1 STAM CBL CDH1 HGS CTNNB1 EPS15 CBLL1 MET STAM2 SH3GL2 SH3GL1 TUBB SHC1 YWHAB NRAS RAP1A MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 FRS2 BRAF MAPK14 EXOC1 SOS1 CRK SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC GBF1 HDAC3 LY96 HBB TRIP11 CEP43 XPO1 STRA6 HMOX1 EP300 TBL1X MED1 RLBP1 CREBBP APOA1 HBA2 NCOR1 TBL1XR1 TLR4 GCC2 NFE2L2 GOLGA4 PPIA FKBP1A CALM1 CAST COG1 YWHAE APP JUN FASLG SOD2 CDC25C FOXO3 CDC25A CDC25B LMNB1 GOLGA2 PRDX2 BCL2L11 CDK5 CAPNS1 CAPNS2 PRDX1 CAPN2 CAPN1 CDK5R1 SLC5A7 NOTCH1 RBX1 IHH GNGT1 SHH GNGT2 WNT5A DHH GP9 GP1BB GP5 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 XRN1 STAT5A STAT5B PIM1 NOX4 GRB2 FZD5 CYP2U1 FZD4 WNT3A CYP1B1 FZD7 KDM1A FZD6 FKBP4 DDX5 FZD8 GNG12 GNG11 GNG13 GNB2 KANK1 GNB1 GNAS PTGES3 GNB4 GNB3 GNB5 SPRED3 SPRED2 SPRED1 CUL3 NF1 IDUA HEXB NCAN HEXA BGN SPTBN1 DCN BCAN MSN VCAN GLB1 HYAL1 CSPG5 IDS CSPG4 GUSB ARSB CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 FLT3 NUP107 PPP1CC PPP2R1B PPP2R1A FGFR2 DYNC1LI1 DYNC1LI2 CLIP1 NUP160 NUP85 RPS27 PPP2R5E SEC13 NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 DYNLL2 DYNC1I2 PPP2CA PPP2CB NUP43 DYNC1I1 RANBP2 DYNC1H1 TAOK1 ACAT1 NUP37 FEN1 MSH6 MSH2 MSH3 PMS2 MLH1 AVPR1B AVPR2 EIF4A2 EIF4A1 AVP AVPR1A TJP1 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 CDK7 ERCC3 H2AC17 ERCC2 H2AC12 MNAT1 FDX1 H2AC1 FDXR FDX2 H2AC19 H2AC25 H2AC14 H2AC21 H2BC12L UNC93B1 AKT2 TLR8 TLR7 MYC AKT3 TLR3 AKT1 CSNK2A1 CSNK2A2 CSNK2B MASP1 MBL2 RPN2 C1QA MAPKAP1 RPN1 PIK3R3 C1S PIK3R2 PIK3R1 PIK3R6 PIK3R5 CGAS LYN LRRFIP1 YES1 IRF7 H4C9 DHX9 ERLIN1 ERLIN2 MOV10 AGO3 AGO4 XRCC6 XRCC5 H2AC20 AGO1 RNF43 AGO2 STING1 CD28 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage GSDMD CASP3 CASP4 IL18 IL1B TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX TNRC6A TNRC6B ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 TP53 UBE2D1 ANAPC10 ANAPC11 IL6 CDC23 UBE2S CDC26 RELA CDC27 CDC16 VENTX ANAPC4 ANAPC5 ANAPC1 ANAPC2 CEBPB NFKB1 CTNNB1 CSF1R CDKN2A FZR1 EHMT2 CCND1 EHMT1 LEF1 MOV10 TCF7L2 AGO3 AGO4 AGO1 TNRC6C CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) DHCR7 TM7SF2 SC5D MSMO1 HSD17B7 NSDHL EBP CYP51A1 DHCR24 LBR LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism HYKK SLC25A21 PIPOX CRYM DLD AASS GCDH ALDH7A1 AADAT PHYKPL DLST DHTKD1 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade ANO5 APP F5 F8 SERPINE1 GPC1 F12 KLKB1 GPC3 GPC2 PRTN3 GPC5 F7 GPC4 F9 GPC6 PROZ AGRN GP1BA F3 PROS1 SERPINC1 F10 F2 PROC SERPINE2 SERPINA5 THBD SERPING1 SMPD1 PF4V1 CD177 PROCR F11 GP9 GP1BB HSPG2 GP5 F2R SDC4 SDC2 SDC3 KNG1 SERPINA10 SDC1 ADAMTS13 SERPIND1 VWF PF4 ANO6 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing OGG1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 SYT10 INS TNRC6A TNRC6B REST NAMPT NPAS4 MDM2 CDK5 FOS CDK5R1 XPO1 PLK2 GEM ARNT ARNT2 SRF CREBBP RBFOX3 BDNF MAPK1 IQSEC3 MAPK3 NR3C1 BMAL1 MOV10 AGO3 RET AGO4 KCNIP3 AGO1 AGO2 TNRC6C STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLG TWNK MGME1 EXOG SSBP1 POLRMT POLG2 RNASEH1 TOP3A COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation LAMB3 COL9A2 COL6A5 PPIB LAMA3 LAMC2 MMP9 LOX COL1A1 LOXL3 COL1A2 LOXL4 PLEC LOXL1 LOXL2 MMP20 P4HB P4HA1 CTSV P4HA2 P4HA3 CTSL CD151 MMP13 ADAMTS2 ADAMTS3 MMP7 COL17A1 COL18A1 COLGALT2 PLOD3 CTSS PXDN COL15A1 COL16A1 PLOD2 PLOD1 CTSB COL13A1 COL14A1 COLGALT1 P3H2 COL11A1 P3H1 COL11A2 COL12A1 PCOLCE P3H3 COL19A1 COL10A1 PCOLCE2 SERPINH1 COL28A1 CRTAP COL26A1 COL27A1 COL24A1 COL25A1 MMP3 COL22A1 COL23A1 ADAMTS14 COL3A1 COL2A1 COL4A2 ITGB4 COL5A1 COL4A1 COL7A1 COL6A2 BMP1 COL5A3 TLL2 COL4A4 TLL1 COL5A2 COL6A1 ITGA6 COL4A3 COL4A6 COL9A1 COL20A1 COL8A2 COL6A3 COL21A1 COL8A1 COL4A5 COL9A3 COL6A6 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRND CHRNG CHRNE CHRNB2 CHRNB4 CHRNA3 CHRNA4 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 RAP1A GAB1 RAPGEF1 MET HGF CRK DOCK7 RAP1B RAC1 CRKL FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate AKR1A1 CRYL1 XYLB DCXR SORD RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions CBFB CLDN5 RUNX1 TJP1 OCLN TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 LGALS3 PPARGC1B CCNB1 CDK1 COL1A1 SRC YAP1 UCMA RB1 CDKN1A CCND1 HIVEP3 HEY1 ABL1 STAT1 SKP2 HEY2 MAPK1 MAPK3 ITGBL1 CDK4 ESRRA MMP13 SATB2 BGLAP HDAC3 GSK3B MSX2 PPARGC1A BMP2 HDAC6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 RBM14 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BAX STUB1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 MAF PSMA7 TWIST2 CBFB TWIST1 PSMB6 RUNX1 PSMB7 SOX9 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 DLX5 PSMC6 DLX6 PSMC3 PSMC4 PSMC1 PSMC2 IHH HDAC4 NR3C1 ESR1 SMAD1 SMAD4 AR SMURF1 SMAD6 GLI3 GLI2 SP7 AKT2 AKT3 AKT1 NKX3-2 HES1 ZNF521 HAND2 ITGA5 PPM1D WWP1 WWTR1 YES1 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation INS IRS1 IRS2 GRB10 INSR REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling CHUK CASP8 LRRC14 USP14 NLRX1 UBA52 TP53 NLRC5 TRAF2 USP18 N4BP1 IKBKB UBB TRAF6 UBC IKBIP IKBKG RPS27A CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions PARVB FLNC LIMS2 LIMS1 ITGB1 FBLIM1 ILK FERMT2 ARHGEF6 ACTN1 FLNA VASP PXN TESK1 RSU1 PARVA ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC TUBA4B TUBA4A CCT6A TUBA8 TUBA1C TUBA1B TUBA1A CCT3 CCT2 TUBB2B TUBB2A TCP1 TUBAL3 TUBA3E TUBA3D TUBA3C CCT8 CCT7 CCT5 CCT6B CCT4 TUBB6 TUBB3 TUBB1 TUBB4B TUBB4A REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP CASP8 TNFRSF10B TNFRSF10A TNFSF10 FAS FASLG TRAF2 RIPK1 FADD TRADD FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation FGF9 FGF20 FGF18 FGF1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling CSF3 SYK UBA52 UBE2D1 ELOB ELOC TYK2 JAK1 UBB RNF7 UBC RPS27A CUL5 STAT5A STAT5B HCK SOCS3 SOCS1 JAK2 UBE2D2 STAT1 LYN STAT3 UBE2D3 CSF3R ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway HLA-B HLA-A B2M HLA-H HLA-C HLA-F HLA-G CTSV CTSS HLA-E CTSL LNPEP PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis CAD UMPS DHODH ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones MBTPS2 MBTPS1 ATF6B HSPA5 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen GP1BA FCER1G ITGB1 GP6 ADAMTS13 GP9 GP1BB ITGA2 LYN ITGA1 GP5 VWF FYN ITGA10 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism RMND5B LDHA MAEA PDPR RMND5A PDK4 PDK3 UBA52 NEK1 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 ARMC8 PDP1 DLD UBB MKLN1 GID4 PDP2 UBC GSTZ1 GID8 RPS27A ME1 RANBP9 WDR26 PDHB INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing GSDMD RELA CASP1 CTSG IL18 IL1A IL1B NFKB1 NFKB2 KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins KIF5C CENPE KIF5B KIF5A KIFAP3 KIF28P KIF12 KIF19 KIF13B KIF1C KIF21A KIF1B KIF21B KIF4B KIF1A KIF4A KIF25 KIF18A KIF6 KIF27 KIF9 KIFC2 KIF16B KIFC1 KIF3B KIF20B KIF3A KIF20A KLC1 KIF18B KLC4 KIF26B KLC3 KLC2 KIF3C KIF11 KIF15 KIF2A KIF2C KIF2B KIF23 KIF22 RACGAP1 KIF26A VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus HSPA1A METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 ODC1 PSMD11 PSMD14 PSMD13 AGMAT SAT1 PSMA7 PSMB6 SMS PSMB7 AZIN2 PSMB4 AZIN1 PSMB5 PSMB2 PSMB3 PSMB1 AMD1 ADRM1 SEM1 PSMC5 SRM PSMC6 PSMC3 PSMC4 PSMC1 NQO1 PSMC2 PAOX PSMD8 PSMD6 PSMD7 PSMD2 OAZ1 PSMD3 OAZ2 PSMD1 OAZ3 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation SERPINA1 PPP6C TFG PPP6R1 PPP6R3 TMED2 ARF4 CTSC TRAPPC2L LMAN1L MAGT1 F5 F8 TRAPPC6A TBC1D20 ACTR1A TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C RAB1A TMED10 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A DERL1 ANKRD28 DERL2 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A OS9 TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 CNIH3 FOLR1 BET1 TUSC3 AREG RNF139 TMEM258 DCTN2 UGGT2 VCP UGGT1 MARCHF6 DCTN3 EDEM3 SEL1L AMFR RNF103 TRIM13 OST4 GBF1 OSTC STT3A STT3B RNF185 DDOST DAD1 COL7A1 ARFGAP1 RNF5 ARFGAP3 COG8 COG7 COG6 COG5 COG4 INS COG3 COG2 COG1 NAPA NAPB LMAN1 GOLGA2 NAPG STX5 YKT6 FUCA1 ST6GALNAC2 PRKCSH FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 MGAT1 GMPPB PMM1 CHST8 MGAT2 GMPPA CGA ST3GAL1 PMM2 ST3GAL2 MPI ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C ARF5 MGAT4A MGAT4B ARCN1 MAN1B1 ST6GALNAC3 ST6GALNAC4 DPAGT1 ALG8 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 ST3GAL6 CD55 KDELR2 B4GALNT2 UBXN1 ARFGAP2 KDELR1 MIA2 SYVN1 ENGASE ST6GALNAC1 CMAS NANP FPGT NGLY1 PGM3 GNPNAT1 NANS GFUS NUDT14 ST6GAL2 SLC35C1 ALG5 GOSR1 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 ANK2 GNE ANK3 UAP1 ANK1 NPL FUOM ALG10B NEU2 NEU3 NEU4 DHRSX CHST10 GOLGB1 SLC17A5 GMDS SPTBN4 AMDHD2 SPTBN5 NEU1 ST8SIA4 ASGR1 SPTA1 ST8SIA5 ST3GAL5 ASGR2 ST8SIA6 SPTBN1 COPZ2 SPTBN2 CTSA COPZ1 NUS1 ALG11 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 GLB1 ST8SIA3 SRD5A3 MAN1A2 GFPT1 MAN1C1 DOLK MAN1A1 NAGK FCSK DOLPP1 SPTAN1 SPTB KDELR3 DCTN1 ARF1 CTSZ FUT3 EDEM1 BET1L MVD SEC23A NSF SAR1B MANEA GRIA1 LHB SEC24B DYNC1LI1 SEC24A DYNC1LI2 UMOD B4GALT2 B4GALT3 MLEC B4GALT1 TMED3 SEC24D TMED7 SEC24C TMED9 HK1 CALR B4GALT6 SEC13 COPG2 COPG1 ALG10 COPB2 COPA B4GALT4 B4GALT5 DYNLL1 PDIA3 COPB1 ST6GALNAC6 MAN2A2 TMEM115 DYNLL2 COPE CANX RAD23B DYNC1I2 DYNC1I1 UBA52 DYNC1H1 ALG14 ALG13 DCTN6 DCTN5 DCTN4 CAPZA3 ACTR10 UBB UBC RPS27A PSMC1 CAPZB CAPZA1 MGAT3 CAPZA2 CSNK1D MIA3 RPN2 RPN1 ARF3 MCFD2 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling JAK1 STAT3 IL6R SOCS3 JAK2 PTPN11 IL6ST IL6 CBL STAT1 TYK2 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL NODAL DAND5 FURIN PCSK6 ACVR2A FOXO3 MAPK1 FOXH1 DRAP1 GDF1 MAPK3 SMAD2 LEFTY1 ACVR1C SMAD4 CRIPTO3 SMAD3 CRIPTO ACVR1B LEFTY2 ACVR2B CFC1 CER1 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation H2AC6 H2AC7 H2AX DNMT3L DNMT3B DNMT3A DNMT1 H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 H3C15 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 UHRF1 H2BC1 H4C9 H2AB1 H2AZ2 H2AC20 H2AC8 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response CYCS AVEN DIABLO CARD8 UACA CASP3 MAPK1 CASP7 APIP MAPK3 XIAP CASP9 APAF1 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling JAK1 PTPN6 IFNG PTPN1 PIAS1 SOCS3 SOCS1 IFNGR1 JAK2 IFNGR2 PTPN11 SUMO1 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 PLCG1 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily H2AX DDX46 DDX42 RBM17 MYOG CDC73 MYOD1 TCF4 H3-3B SUPT16H SMNDC1 U2SURP SKIC8 H3C8 CTR9 RTF1 H2AJ CHD2 LEO1 PAF1 H3C15 SSRP1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 H2BC9 SF3A1 H2BC8 SF3A2 H2BC5 PHF5A H2BC3 H2BC1 SNRPN CHERP H2AB1 H2AC8 H2AC6 H2AC7 SNRPA1 PUF60 SNRPB2 SNRPD2 TCF12 SNRPD1 SNRPD3 H2AC19 SNRPG H2AC14 H2BC12L SNRPE SNRPF SNRPB H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CHD1 TCF3 DHX15 H4C9 H2AZ2 H2AC20 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling ERBB2 NRG1 NRG2 GRB7 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal ASCC2 ASCC3 ALKBH2 MGMT ALKBH3 FTO ALKBH5 ASCC1 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway TUBB2B TUBB2A TUBA4B TUBA4A TUBAL3 ARL2 TUBA3E TBCD TBCC TBCB TBCA TUBA3D TUBA3C TBCE TUBB6 TUBA8 TUBB3 TUBB4B TUBA1C TUBB1 TUBB4A TUBA1B TUBA1A REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand GSDMD TLR1 S100A1 TLR6 APOB CD36 TLR2 LBP S100A9 S100A8 GSDME FGB FGA FGG TLR4 LY96 TLR7 CD14 HMGB1 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells LPO MPO ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases TIMP2 TIMP1 MMP13 FURIN MMP8 SPOCK3 PRSS2 CTSG MMP14 MMP16 MMP9 KLKB1 MMP7 COL18A1 PLG KLK2 PRSS1 CTRB2 CTRB1 MMP25 MMP24 CMA1 TPSAB1 MMP3 MMP10 MMP11 MMP15 MMP17 MMP1 CTSV CTSK MMP2 ELANE INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO7 ANO4 FURIN ANO5 ANO2 TMPRSS2 ANO3 ANO1 ACE2 ANO10 ANO8 ANO9 ANO6 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 FGF9 FGF20 FGF23 FGF16 FGF18 PIK3R1 PIK3CA GAB1 FRS2 FGF1 FGF2 PTPN11 FGF4 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 PCNA UBA52 RFC5 RFC3 RPA1 RPA2 RFC4 UBB RFC1 REV3L RFC2 UBC RPA3 RPS27A REV1 MAD2L2 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade GUCY2F NMT1 CALM1 PRKCQ NMT2 PRKCA PDE6B SLC24A1 PDE6A RHO PDE6G SAG CNGA1 RCVRN GNAT1 PPEF1 CNGB1 METAP1 METAP2 CAMKMT RGS9BP GNGT1 GNB1 GRK1 GUCA1B GUCA1A FNTA GUCY2D GUCA1C GRK7 FNTB APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 HMGA1 PPIA PSIP1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage CASP3 CASP7 CYCS XIAP CASP9 APAF1 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation PTPN3 ARHGEF7 UBA52 EGFR UBB SH3GL3 SH3KBP1 UBC RPS27A STAM CBL HGS PTPRK EPS15 TGFA STAM2 SH3GL2 SPRY1 SH3GL1 SPRY2 EREG BTC EPGN HBEGF EPS15L1 EPN1 CDC42 EGF AREG PTPN12 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B ROBO1 RHOA SLIT2 VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance VLDLR APOC1 LSR APOB APOC4 APOBR CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF5 TIAM2 YWHAE OBSCN ARHGEF4 ARHGEF7 ARHGEF26 UBA52 NGEF ARHGEF6 FGD1 FGD2 RAC1 KALRN GNA13 FGD3 FGD4 BCL2L11 ARHGEF33 ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 AATF VAV1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B MAPK8 NGFR SQSTM1 CASP3 TIAM1 NGF SOS1 VAV3 CASP2 VAV2 RASGRF2 ARHGEF18 ARHGEF10L BAD AKAP13 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 BEX3 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 ECT2 PREX1 SOS2 MCF2L NET1 TRAF6 ITGB3BP ABR ARHGEF16 ARHGEF40 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFB8 NDUFAF2 SFXN4 NDUFAF3 MT-ND6 NDUFAF1 MT-ND4 TMEM186 MT-ND5 MT-ND2 MT-ND3 ACAD9 MT-ND1 NDUFA5 DMAC1 DMAC2 ECSIT TIMMDC1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 NDUFA10 HSPA9 NDUFB10 NDUFB11 OXA1L NDUFV3 NDUFV2 NDUFV1 COA1 NDUFC2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 NDUFAB1 HSCB PYURF TMEM126A TMEM126B NDUFS3 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation HBB HBA2 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family PLCG2 FCER1G SYK MUC12 MUC13 MUC15 CLEC10A CLEC4A CLEC4C CLEC4D CLEC4E MUCL1 CLEC6A MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 LYN MUC4 MUC6 MUC16 MUC17 FYN MUC19 MUC5B MUC20 MUC21 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy TBK1 TOMM40 UBE2V1 UBA52 MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN UBC RPS27A TOMM70 TOMM20 UBE2L3 TOMM22 UBE2N MAP1LC3A MTERF3 ATG9A VDAC3 ATG12 VDAC2 ATG5 VDAC1 UBE2D2 SQSTM1 UBE2D3 PRKN PINK1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 KAT2B MNAT1 KAT2A TBP MBD3 RRN3 TTF1 ERCC6 GATAD2B UBTF GATAD2A POLR1A POLR1B POLR1E POLR1F MTA1 POLR1G HDAC1 POLR1H HDAC2 EHMT2 TAF1D MTA3 POLR1C TAF1B TAF1C TAF1A POLR1D CHD4 RBBP4 CCNH CHD3 RBBP7 POLR2E POLR2F POLR2H RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation ZNF521 UCMA GLI3 SATB2 RB1 HEY1 BGLAP ABL1 MAF HEY2 WWTR1 MAPK1 HDAC3 HDAC6 SP7 YES1 CBFB MAPK3 COL1A1 SRC AR HES1 YAP1 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation MIXL1 CTNNB1 NANOG POU5F1 TRIM33 TCF7 LEF1 FOXH1 SMAD2 SOX2 SMAD4 EOMES SMAD3 TBXT TBPL2 BMP4 GSC SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease GAB1 HRAS SOS1 PLCG1 FRS2 PIK3CA PIK3R1 FGFR4 NRAS NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins SYT10 DBNL SYT2 SYT1 STX1A GRIN2B SHARPIN EPB41L3 CASK LIN7A LIN7C LIN7B EPB41L1 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 GRIN2C DLGAP1 DLGAP3 DLGAP2 GRIN2D DLGAP4 GRIN1 DLG3 BEGAIN GRIN2A DLG4 DLG2 APBA3 APBA2 SYT7 GRM1 LRRTM3 GRM5 LRRTM4 LRRTM1 LRRTM2 SYT9 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 PDLIM5 NLGN4Y NLGN4X SYT12 APBA1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions PARD6G PARD6B PRKCI CLDN2 PATJ F11R PALS1 CLDN6 CRB3 PARD6A CLDN4 CLDN3 PARD3 CLDN9 CLDN8 CLDN7 CLDN22 CLDN20 CLDN23 CLDN1 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 CLDN5 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements PSMA5 PSMA6 PSMA3 DIS3 PSMA4 PSMA1 PARN NUP214 PSMA2 EXOSC7 UBA52 EXOSC6 EXOSC5 PSMD12 EXOSC4 PSMD11 EXOSC9 KHSRP PSMD14 HSPA1A PSMD13 EXOSC8 EXOSC3 EXOSC2 PSMA7 EXOSC1 PSMB6 PSMB7 PSMB4 TNPO1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 EIF4G1 YWHAZ PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 YWHAB SET ANP32A TNFSF13 ELAVL1 MAPK14 HSPA8 MAPK11 MAPKAPK2 PRKCD PRKCA HSPB1 AKT1 PABPC1 XRN1 XPO1 DCP1A DCP2 ZFP36 PSMD8 ZFP36L1 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members STAT3 BCL2L11 BMF BID PMAIP1 BCL2 BBC3 BAD BCL2L1 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer TP53 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) LYN EPO GAB1 PIK3CD IRS2 PIK3CA PIK3R1 PIK3CB JAK2 PIK3CG PIK3R5 EPOR FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis CD3G RAC1 VAV1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 IGHG3 IGHG4 IGHG1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 WASF3 MYO10 MYO1C SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TYW2 TRMT5 TYW1 LCMT2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS LYN EPO HRAS RAPGEF1 SOS1 VAV1 IRS2 SHC1 JAK2 EPOR CRKL NRAS DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 AMN CBLIF CUBN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation PPP2CA PPP1CC PPP2CB PPP2R1B PPP2R1A CALM1 CAMK2B CAMK2D CAMK2A SRC CAMK2G PPP2R5E PHB1 ARAF PPP1CB PPP2R5B PPP2R5A PPP2R5D JAK2 PPP2R5C YWHAB BRAP MARK3 NRAS MRAS KSR1 SHOC2 HRAS MAP2K1 MAP2K2 RAF1 BRAF MAP3K11 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins TNRC6A TNRC6B CDH19 SP1 ZC3H12A ZEB2 ANGPTL4 CTNND1 HEYL CTNNB1 SOX10 PRDM8 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 ADAM33 JUP ADAM19 ILF3 CDH11 SNAI1 MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling HSP90AA1 CDC37 ERBIN ERBB2 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs CASP3 CASP7 CYCS XIAP CASP9 DIABLO APAF1 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling JAK1 STAT3 CRLF1 CANX IL27 IL27RA EBI3 JAK2 IL6ST STAT1 TYK2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 MUC1 MUC2 MUC12 MUC7 MUC13 MUC4 MUC6 MUC15 MUC16 MUC17 MUC19 MUC5B MUCL1 MUC20 MUC21 MUC3A MUC5AC GALNT12 MUC3B DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions BTK PLCG2 TYROBP SOS1 VAV3 CD300E SYK SIRPB1 RAC1 VAV2 CD300LB HLA-B KLRK1 B2M HLA-C KLRD1 KIR2DS2 HLA-E PIK3CB KIR2DS4 KIR2DS5 NCR2 PIK3R2 PIK3R1 SIGLEC16 PIK3CA TREM2 SIGLEC15 KLRC2 LCK NRAS TREM1 HRAS SIGLEC14 CLEC5A PLCG1 FYN LCP2 KIR3DS1 GRAP2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ACR SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly MTTP APOC1 APOB P4HB APOC4 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ABCD1 RPS27A DERL3 ADRM1 DERL1 DERL2 SEM1 PSMC5 PSMC6 PSMC3 OS9 PSMC4 PSMC1 PSMC2 ABCA1 ABCA12 ABCG8 ABCG5 ABCB6 VCP ABCB4 ABCC9 SEL1L ABCA3 ABCD4 ABCC6 LMBRD1 RNF185 ABCB11 KCNJ11 ABCC8 ABCC2 APOA1 RNF5 ERLEC1 PSMD8 CFTR PSMD6 ERLIN1 PSMD7 ERLIN2 PSMD2 PSMD3 PSMD1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation RAP1A MAPK1 RAPGEF1 MAPK3 MAP2K1 MAP2K2 FRS2 BRAF NGF YWHAB CRKL RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription CDKN1A ZFHX3 TGFB1 SMAD4 TP53 SMAD3 RUNX3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint FBXW11 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CHEK2 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK3 MAPK14 MAPK11 CHEK1 CSNK1E CSNK1A1 NEK11 GSK3B PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle ARHGAP22 ARHGAP20 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 DOCK6 DOCK9 TFRC ARAP1 FMNL1 FMNL2 LAMTOR1 PAK1 PAK3 PAK2 TIAM1 RASGRF2 PARD6A LBR ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 STARD8 CPNE8 DOCK8 SNAP23 FNBP1L DAAM1 FNBP1 DOCK10 SCRIB SYDE1 ARHGAP42 TRIO ARHGEF25 CDC42BPB ITSN1 CDC42BPA IQGAP3 ARHGAP1 GIT1 ARHGDIG STOM FMNL3 ARHGAP5 ARAP2 ARHGAP35 ECT2 PREX1 STARD13 ARAP3 OPHN1 JUP ARHGDIA BCR CDC42 MCF2L ARHGDIB ARHGAP17 TMPO ABR PLEKHG3 RACGAP1 ARHGEF16 DLC1 ARFGAP3 DEPDC1B PLEKHG2 CDC42EP1 ARHGEF15 GIT2 ARHGAP26 ARHGEF19 BAIAP2 ARHGEF5 RAB7A ARHGEF4 VAMP3 ARHGEF26 ARHGEF7 NGEF ARHGEF6 PLD1 FGD1 IQGAP2 FGD2 GNA13 ARHGAP39 ARHGAP21 FGD3 FGD4 SRGAP3 SRGAP2 YKT6 SRGAP1 PAK4 MCF2 DOCK7 KTN1 VANGL1 ARHGAP32 DIAPH3 STEAP3 WIPF1 WIPF2 WDR91 CAV1 WIPF3 WDR81 CDC42SE2 ARHGAP9 ARHGAP4 GMIP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 VAV3 WASL CHN1 FARP1 DEF6 WAS SHKBP1 VAV2 FAM13B GOLGA8R ARHGAP11B TAGAP PLEKHG4 PAK6 PLEKHG1 PAK5 ARHGAP10 ARFGAP2 MYO9B SPATA13 PIK3R2 IQGAP1 PIK3R1 SH3PXD2A PLEKHG4B ARHGAP44 DOCK11 ARHGAP40 RALBP1 MAP3K11 KCTD3 PREX2 ARHGAP45 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer FURIN CCNK CCNT2 TRIM33 CCNT1 CCNC UBA52 UBE2D1 MEN1 SERPINE1 PPM1A JUNB RNF111 COL1A2 UBB UBC RPS27A NEDD4L CDK9 CDKN2B HDAC1 ATP1B4 MAPK1 TFDP1 MAPK3 SNW1 TFDP2 SKIL SMAD2 SMAD4 SMAD3 SMURF2 SMAD7 CDK8 YBX1 NCOR2 SP1 RBL1 MYC USP9X EP300 SKI E2F4 PARP1 WWTR1 NCOR1 E2F5 UBE2D3 TGIF1 TGIF2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis POMC HSD3B2 CYP11B2 HSD11B1 CYP21A2 HSD11B2 HSD3B1 SERPINA6 CYP11B1 CYP17A1 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 GCK NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 GCKR AAAS DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination UBE2D1 USP34 MDM2 MDM4 CDK1 CCNA2 CCNA1 STAM HGS VDAC3 STAM2 VDAC2 VDAC1 H2BC9 H2BC8 NEDD8 H2BC5 H2BC3 H2BC1 H2AC8 H2AC6 H2AC7 VCP RHOA H2BC26 H2BC21 TOMM20 EP300 TAB1 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CFTR TRAF6 AXIN2 H2BC18 CDC25A BECN1 IDE TAF10 USP30 IL33 RHOT1 POLB ACTB ADRB2 IFIH1 RNF135 TRIM25 PTRH2 MAVS TP53 RIGI KAT2B KAT2A ATXN7 BAP1 UCHL1 SENP8 SNX3 UCHL3 HCFC1 FOXK2 FOXK1 MBD5 OTUD7A MBD6 NLRP3 ASXL1 ASXL2 USP11 USP33 STAMBPL1 OTUD5 VCPIP1 UFD1 KDM1B MYSM1 OTUB1 USP13 TNKS OTUB2 TNKS2 RNF146 GATA3 OTUD3 TGFBR1 TNIP1 SUDS3 TGFBR2 TNIP3 USP17L4 USP17L5 USP17L8 RNF128 USP7 TADA2B USP2 WDR20 USP17L3 USP17L1 USP5 USP3 APC FKBP8 SKP2 STAMBP ACTL6A USP10 DDB2 CDC20 USP17L30 YOD1 MAT2B ZRANB1 USP17L21 TGFB1 USP17L20 USP17L22 USP17L2 TOMM70 USP17L15 USP9X USP17L18 RCE1 USP17L17 USP17L19 USP17L10 USP17L12 TADA3 USP17L11 USP17L13 TRAF2 RUVBL1 NFRKB USP37 ACTR5 USP47 USP48 RAD23A PSMD8 USP49 USP42 ACTR8 PSMD6 YY1 USP44 RAD23B BIRC2 PSMD7 INO80C BIRC3 PSMD2 PRKN INO80B PSMD3 INO80E USP16 PSMD1 INO80D USP12 IKBKG RIPK1 ABRAXAS2 USP19 KEAP1 MAP3K7 USP24 TFPT USP25 MCRS1 USP26 INO80 PSMA5 USP20 PSMA6 USP22 PSMA3 USP28 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 OGT PSMD11 PSMD14 PSMD13 RNF123 RIPK2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 TRAF3 UBB PSMB2 PSMB3 UBC SIAH2 PSMB1 RPS27A ADRM1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FOXO4 USP14 ATXN3L TRIM4 JOSD2 ATXN3 JOSD1 NOD1 NOD2 USP18 WDR48 TNFAIP3 OTUD7B TNIP2 ESR1 USP21 USP4 SMAD2 SMAD1 CYLD SMAD4 SMAD3 AR BRCC3 SMURF2 CLSPN BABAM1 BABAM2 UIMC1 SMAD7 ABRAXAS1 BRCA1 H2AC17 H2AC12 AXIN1 CCP110 H2AC1 USP15 H2AC19 H2AC25 H2AC14 H2AC21 PTEN MYC UCHL5 USP8 ARRB1 ARRB2 HIF1A MUL1 BARD1 TRRAP H2AC20 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events CALM1 PRKACG PRKACB PLCB4 MAPK1 GNAT3 AHCYL1 PRKCG KPNA2 ADCY9 PRKAR1B PRKAR2B PRKACA PDE1C PDE1B PDE1A GNAI3 GNAL ADCY4 GRK2 PRKCD PRKCA NBEA PLA2G4A PLCB3 ADCY3 PLCB1 PRKX PLCB2 ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 GNAQ CAMK2A ADCY7 ADCY6 PRKAR2A ITPR1 GNAI1 ADCY5 ITPR2 GNAI2 ITPR3 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 GNA14 GNA15 GNA11 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) IDS FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct CTNNB1 PAX8 GATA3 LHX1 ID4 HOXB4 PCDH19 WFDC2 PLAC8 MECOM HOXA6 EMX2 OSR1 RET FGF2 NPNT PAX2 BMP4 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins POM121C NUP42 PHC2 NUP62 NUP43 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 RANBP2 PHC3 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 BMI1 RING1 NUP37 RNF2 L3MBTL2 ZBED1 HDAC1 SUZ12 HDAC4 UBE2I SATB1 PIAS1 NUP107 CBX5 SUMO1 SUMO3 SUMO2 SATB2 NUP160 NUP85 SEC13 NUP133 HDAC2 PCGF2 H4C9 CHD3 NUP205 POM121 NUP188 AAAS CBX8 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events MMGT1 MAGT1 ADD2 PIP RHCG RHBG ADD1 ADD3 LRRC8C RHAG LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 CTNS NIPAL2 NIPAL3 AZGP1 ANKH NIPA1 MRS2 TUSC3 NIPA2 SLC66A1 DMTN AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy ATM MTMR14 PRKAG1 HSF1 PRKAG2 RPTOR PRKAG3 TSC2 TSC1 RRAGA RRAGC RRAGB RRAGD MTMR3 ATG14 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 WIPI1 VDAC3 VDAC2 VDAC1 UBE2D2 SQSTM1 EEF1A1 HSPA8 TBK1 VCP UBE2V1 DYNC1LI1 DYNC1LI2 PCNT PIK3R4 HBB TOMM70 MLST8 TOMM20 UBE2L3 TOMM22 UBE2N ARL13B PIK3C3 DYNLL1 CETN1 PRKAA1 PARK7 HSP90AA1 PRKAA2 RNASE1 CHMP4C DYNLL2 CHMP4B GFAP HDAC6 LAMP2 CHMP3 UBE2D3 CHMP4A PLIN2 CFTR CHMP6 GABARAPL3 CHMP7 ATG3 GABARAPL1 ATG9B PRKN ATG10 DYNC1I2 ATG13 ATG101 ATG16L2 ATG16L1 MTOR WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B CHMP2B ATG4A CHMP2A ATG4D TOMM40 DYNC1I1 WDR45B AMBRA1 UBA52 DYNC1H1 BECN1 UVRAG MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN ATG7 UBC RPS27A MAP1LC3A GABARAP FUNDC1 USP30 ATG9A ATG12 PEX5 ATG5 NBR1 GABARAPL2 PLIN3 ULK1 HSP90AB1 PRKAB2 IFT88 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B EPAS1 MTERF3 TSG101 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 VPS28 PINK1 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 PPP2CA PPP2CB PPP2R1A SOS1 UBA52 KLB UBB FGF1 FGF2 UBC FGF4 RPS27A CBL FGF6 FGF9 FGF20 FGF23 FGF16 MKNK1 FGF19 FGF18 SPRY2 PIK3R1 PIK3CA FGFR4 NRAS GAB1 MAPK1 FRS3 HRAS MAPK3 PLCG1 FRS2 BRAF PTPN11 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway TNFRSF10B TNFRSF10A FAS FASLG UNC5A DAPK1 MAGED1 TICAM2 UNC5B TICAM1 DAPK2 LY96 DAPK3 CD14 APPL1 CASP9 TRADD CASP8 TNFSF10 TRAF2 DCC CASP3 TLR4 RIPK1 FADD MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters SLC17A5 SLC5A8 SLC25A1 SLC25A11 SLC25A10 SLC5A12 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 SOD3 TKT PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PRDX1 PSMB5 UBB SLC7A11 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NOTCH1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PGD PSMC2 CDKN2A ABCG2 SQSTM1 ABCC1 IDH1 EGF BCL2 PDGFA AREG BCL2L1 TALDO1 SP1 GSTA1 GSK3B MYC BACH1 G6PD ATF4 HMOX1 EP300 NQO1 GSTA3 CREBBP GCLC MAFG PRKAA2 GCLM SRXN1 CHD6 ME1 ABCC3 PSMD8 MAFK PSMD6 PSMD7 PSMD2 NFE2L2 PSMD3 TXN PSMD1 TXNRD1 BTRC KEAP1 CCL2 SKP1 ABCF2 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling IFNA8 PTPN6 IFNAR1 IFNA21 IFNA14 IFNA16 IFNA17 IFNB1 IFNA10 SOCS3 SOCS1 TYK2 USP18 JAK1 STAT2 PTPN1 IFNA5 IFNA4 IFNA7 IFNA6 PTPN11 IFNA1 IFNA2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres FBLN2 FBLN5 TGFB2 MFAP5 ITGAV MFAP4 VTN MFAP3 MFAP2 LTBP4 LTBP2 LTBP3 LTBP1 ITGB8 TGFB1 ITGB6 TGFB3 ITGB5 BMP4 ITGA8 GDF5 ITGB1 ITGB3 BMP7 BMP2 EFEMP2 EFEMP1 BMP10 FBLN1 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis ALDH9A1 SHMT1 TMLHE BBOX1 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer PTEN INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling MAPK8 IL1RL2 IL1RAPL1 IL1F10 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway MAPK1 MAPK3 MAP2K1 MAP2K2 RAF1 BRAF RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination ZNF473 SNRPD3 NCBP1 SNRPG NCBP2 CPSF1 CSTF3 CPSF4 SNRPE CPSF3 CSTF2 CPSF2 SNRPF CSTF2T WDR33 SNRPB NUDT21 PCF11 CLP1 CSTF1 FIP1L1 PAPOLA SYMPK CPSF7 LSM10 SLBP LSM11 PABPN1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation FGF9 FGF20 FGF23 KLB FGF16 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET2 TET1 TDG TET3 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription EZH2 H2AX FOXA2 H3-3B TWIST2 TWIST1 H3C8 H2AJ H3C15 ZMYM2 RB1 HDAC1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 MAPK1 WT1 H2BC1 SMARCA4 MPHOSPH8 MAPK3 FOXQ1 SNAI2 H2AB1 TLE1 ZBTB33 H2AC8 H2AC6 PKM H2AC7 KLF9 MCRIP1 FOXJ2 STRAP FOXP2 TCF12 SP1 ARID1A H2AC19 H2AC14 H2BC12L ZEB2 ZEB1 H2BC26 H2BC21 CTBP2 CTBP1 EED H2BC17 H2BC12 TFAP2A H2BC13 H2BC14 H2BC15 KDM1A HDAC2 H2BC11 SIRT1 TCF3 H4C9 SNAI1 RBBP4 RBBP7 H2AZ2 H2AC20 KMT5A ZNF217 TGIF2 KLF4 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling TNRC6A TNRC6B RXRB MYLIP NCOR2 SCD HDAC3 UGT1A3 ANGPTL3 GPS2 ABCG1 CETP NRIP1 EP300 KDM4A TBL1X FASN NCOA1 KDM1A ABCA1 APOC4 NR1H3 APOE PCK1 NCOR1 APOC2 NR1H2 TBL1XR1 APOC1 KDM3A KDM1B FABP6 APOD ARL4C EEPD1 MOV10 AGO3 AGO4 PLIN1 RXRA AGO1 ABCG8 AGO2 ABCG5 TNRC6C REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 ODC1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 AZIN1 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 NQO1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 OAZ1 PSMD3 OAZ2 PSMD1 OAZ3 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA LINGO1 MAG MCF2 OMG RTN4 RHOA NGFR DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system STRA6 RDH12 OPN1LW LRAT RLBP1 OPN1MW TTR NAPEPLD ABCA4 RBP4 RDH5 OPN1SW RBP1 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism NMNAT2 PARP6 NMNAT1 PARP4 PARP16 NUDT12 PARP9 PARP14 SLC25A51 NNMT PARP8 NADK PARP10 NADK2 NAPRT NAMPT NAXE NAXD NT5E NADSYN1 SLC5A8 BST1 QPRT SLC22A13 NMRK2 NMRK1 CD38 RNLS NMNAT3 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain F8 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle GIT2 WWP2 EPHA2 ARHGEF7 ARHGEF6 ARHGAP31 ARHGAP30 SRGAP2 PAK4 ITSN2 SPTBN1 PEAK1 PARD6A SRC VANGL1 STAM USP9X HGS PAK1 MYO6 STAM2 RHOU PAK3 SPTAN1 PIK3R2 IQGAP1 PAK2 CLTC PIK3R1 NCK2 GIT1 NCK1 TXNL1 CDC42 WDR6 PTK2B DST DEPDC1B DLG5 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation HADHB HADHA PCTP ACADL ACAD11 ACAD10 THEM4 ACAA2 ACOT11 ACOT12 ACOT13 ACBD7 ACBD6 ACSF2 DBI MECR ECI1 ACADM DECR1 ECHS1 ACSM3 MCEE NDUFAB1 ACSM6 PCCA HADH MMAA ACOT2 ACADS PCCB MMUT ACOT9 ACOT7 ACOT1 MCAT ACOT7L ACADVL THEM5 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling CASP3 BEX3 YWHAE NGF NGFR CASP2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair RAD1 ATM ACD RAD9B ATR H2AX RAD9A CETN2 TERF1 TERF2 H2AJ CCNA2 CCNA1 POT1 RNF4 TERF2IP RCHY1 ERCC6 MAPK8 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 VCP COPS5 FAAP100 H2BC26 H2BC21 UBE2N H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 FAAP24 FAAP20 H2BC11 FANCM FANCL FANCA FANCB H2AZ2 FANCE FANCG FANCF ELL CHEK2 RNF111 CENPX MGMT RBX1 TCEA1 POLB ACTB APEX1 XRCC1 LIG3 TRIM25 TP53 DCLRE1C RIF1 LIG4 PAXIP1 NHEJ1 XRCC4 SMARCA5 PPP5C TDP2 TDP1 BAP1 ISY1 UBXN1 GPS1 POLL BAZ1B APBB1 KDM4A POLQ MDC1 EYA1 EYA2 POLM EYA3 EYA4 COPS4 COPS2 UFD1 UBE2T KDM4B PPIE LIG1 USP7 NPLOC4 XAB2 ABL1 ACTL6A CDK2 USP10 REV3L SIRT6 PCLAF FANCI POLI DDB2 USP43 REV1 KPNA2 MAD2L2 SPRTN FANCC AQR ERCC8 PARG ADPRS PRPF19 ISG15 PNKP RUVBL1 NFRKB PARP1 PARP2 ACTR5 USP45 RAD23A CHD1L ACTR8 YY1 RAD23B INO80C INO80B INO80E INO80D XPA COPS7B COPS7A XPC UBE2L6 TFPT MCRS1 INO80 COPS3 ALKBH2 COPS6 ERCC4 HERC2 ERCC1 ERCC5 COPS8 UBA52 DCLRE1B MPG DCLRE1A FAN1 POLN UBB UBC CENPS RPS27A FEN1 MSH6 SEM1 MSH2 MSH3 PMS2 MLH1 PIAS4 PIAS3 UBE2I WDR48 FANCD2 USP1 UBE2B CUL4A CCNH DDB1 DTL RAD18 POLR2A PPP4R2 PIAS1 POLR2B CUL4B TIPIN POLR2C TIMELESS POLR2D ALKBH3 BRCC3 POLR2E PPP4C FTO POLR2F ALKBH5 CLSPN SUMO1 POLR2G TP53BP1 SUMO3 POLR2H ASCC1 BABAM1 SUMO2 ASCC2 POLR2I BABAM2 ASCC3 POLR2J UIMC1 POLR2K RNF168 POLR2L ABRAXAS1 GTF2H1 MUS81 RNF8 NSD2 GTF2H2 MRE11 BRCA1 RAD52 BRCA2 GTF2H3 EME1 KAT5 GTF2H4 EXO1 GTF2H5 EME2 CDK7 FIRRM CHEK1 ERCC3 NBN ERCC2 MNAT1 TOPBP1 POLK POLE POLH H2AC19 GEN1 H2AC14 RFC5 H2BC12L RFC3 RMI2 RFC4 RFC1 SLX1B RFC2 RMI1 TOP3A UBE2V2 HUS1 SPIDR RAD51B UBA7 RAD51D OGG1 RAD51C DNA2 NTHL1 RHNO1 TDG MBD4 BLM RTEL1 SMUG1 NEIL3 PCNA NEIL2 RAD51AP1 NEIL1 POLD3 POLD4 WRN BRIP1 SLX4 FIGNL1 POLD1 POLD2 RBBP8 ATRIP BARD1 ZNF830 H4C9 XRCC2 TINF2 PRKDC XRCC3 UVSSA RPA1 RPA2 PALB2 POLE4 RAD50 XRCC6 RAD51 XRCC5 H2AC20 RPA3 POLE2 POLE3 RAD17 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD AHCY MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors CHRM1 CHRM4 CHRM5 CHRM2 CHRM3 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 ITCH UBA52 SPARC UBB PSENEN PSEN2 SRC PSEN1 UBC APH1A YAP1 NCSTN RPS27A APH1B EREG BTC HBEGF SHC1 APOE NRAS HRAS S100B EGF ESR1 NEDD4 GABRG3 GABRG2 PGR SOS1 ADAM17 NRG2 GABRB3 NRG3 GABRB2 NRG4 EGFR GABRB1 DLG4 MXD4 NRG1 CSN2 STMN1 STAT5A ADAP1 TAB2 CXCL12 WWOX PIK3CA PIK3R1 GABRQ GABRA1 WWP1 NCOR1 GFAP BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB HADHA ACADL ECHS1 HADH NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance ACHE SLC6A4 MAOA TOMT SLC6A3 BCHE ALDH2 SLC22A2 COMT SLC22A1 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes EZH2 H2AX ASH2L SMARCB1 EPC1 JMJD6 SMARCC1 SMARCC2 H3C8 KDM6B H2AJ H3C15 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 RIOX2 SMARCA2 SMARCA4 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 PBRM1 KMT2A KMT2C BRWD1 ATF2 NFKB2 PRMT5 WDR77 HDAC3 SMARCD3 ARID2 DPY30 H2BC26 H2BC21 WDR5 EP300 EED TBL1X H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 H2BC15 NCOA2 CREBBP H2BC11 NCOR1 TBL1XR1 CARM1 CHD4 RBBP4 CHD3 RBBP5 CLOCK RBBP7 H2AZ2 H2BC18 MTA2 REST PHF20 DNMT3A TAF9 KDM4C PAX3 TAF12 TAF10 HDAC1 SETD1B SETD1A KDM5A ACTB KDM6A PADI2 ING5 BRD1 NCOR2 KAT2B KAT2A ATXN7 GPS2 KDM4A HCFC1 KDM1A KDM3A KDM1B KDM4B ARID4A ARID4B MEAF6 SAP30 YEATS4 BRMS1 PHF21A SUDS3 RCOR1 HMG20B SAP30L TADA2B SAP18 KAT6A JADE1 JADE3 JADE2 KAT7 SUPT20H ATXN7L3 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 CCND1 ENY2 TAF5L DMAP1 MRGBP TADA1 ING4 ING3 VPS72 MSL2 MSL3 SUPT3H ACTL6B CDK4 MSL1 TAF6L ACTL6A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 KAT8 MBD3 MBIP KAT14 DR1 TADA2A ZZZ3 GATAD2B GATAD2A YEATS2 TADA3 SGF29 SMARCD1 KANSL1 HDAC2 KANSL2 SMARCD2 KANSL3 RUVBL1 HDAC8 SMARCE1 KMT5A MCRS1 RPS2 USP22 PHF2 KDM5C HDAC10 KDM3B KDM5D PHF8 UTY KDM2A OGT KDM2B PADI3 KDM4D PADI4 ARID5B PADI1 PADI6 RELA PRMT6 KMT2D NFKB1 PRMT1 KMT2B MTA1 PRDM16 MTA3 SMYD2 KDM7A BRPF1 BRPF3 NSD2 KDM5B KAT5 SUV39H2 SETD2 H2AC17 SETD3 H2AC12 PRDM9 SETD6 PRMT7 SUV39H1 PRMT3 RUVBL2 ARID1A DOT1L H2AC1 ARID1B SETD7 COPRS H2AC19 H2AC25 NSD3 H2AC14 H2AC21 MECOM NSD1 KMT5B SMYD3 ATF7IP SETDB1 KMT5C SETDB2 ASH1L AEBP2 SAP130 EHMT2 JAK2 EHMT1 H4C9 TRRAP EP400 H2AC20 SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste KCNJ2 OTOP1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins ALOX15 LTA4H CYP1A2 CYP1A1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling PTPN6 SH2B3 SH2B2 SOS1 SOCS6 KIT SOCS1 PRKCA LCK LYN YES1 FYN CBL VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway FANCC ATR MUS81 ERCC4 ERCC1 DCLRE1B EME1 UBA52 DCLRE1A FAN1 EME2 POLN CENPX UBB SLX1B UBC FAAP100 CENPS RPS27A FAAP24 SLX4 FAAP20 WDR48 ATRIP FANCD2 USP1 UBE2T RPA1 FANCM RPA2 FANCL FANCA FANCI FANCB FANCE RPA3 FANCG FANCF CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 CDC25A PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 MAX PSMC5 PSMC6 PSMC3 PSMC4 RB1 PTK6 PSMC1 LIN54 CDKN1A PSMC2 CDKN1B CKS1B LIN52 LIN37 LIN9 CCND1 CABLES1 E2F1 WEE1 SKP2 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 CDK7 MNAT1 RBL2 AKT2 MYC AKT3 AKT1 E2F4 E2F5 PSMD8 RBBP4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SKP1 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria AUH DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD OPLAH SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus IP6K1 IP6K2 IPMK IPPK DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid PNLIPRP3 CEL LIPF CLPS PNLIPRP1 PNLIPRP2 PNLIP SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids ALOX5 GPX1 GPX4 PON3 PON2 PON1 ALOX5AP GPX2 LTC4S CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGHG3 IGKV2D-40 IGHG4 IGHV3-11 IGHG1 IGHV3-13 IGKV1D-16 IGHG2 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 CRP C1QB IGKV3-20 IGHV4-34 C1QA IGHV1-2 IGHV1-46 IGHV4-39 C1S IGHV C1R IGKV2-29 IGKV2-28 C1QC IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species TXNRD2 SOD3 ATOX1 SOD1 CCS CYCS SOD2 PRDX2 PRDX1 AQP8 GPX2 NUDT2 NCF1 NCF2 PRDX3 NCF4 PRDX6 NOX4 NOX5 GSTP1 ERO1A CYBB CYBA GPX1 P4HB GPX3 GPX6 TXN2 GPX5 GPX8 TXN GPX7 ATP7A TXNRD1 CAT G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase PPP2CA PPP2CB PPP2R1B PPP2R1A PPP2R2A UBA52 CDK7 CUL1 MNAT1 RBL2 RBL1 UBB UBC RPS27A CDKN1C RB1 CDKN2D PTK6 CDKN1A CDKN2B CDKN1B CKS1B CDKN2C CCND3 CDKN2A CCND2 CCND1 JAK2 E2F1 E2F2 ABL1 E2F3 E2F4 SKP2 LYN E2F5 PPP2R3B CDK6 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 SKP1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network RAC1 VAV1 SRC PIP5K1A PIP5K1B TGFA MET EREG BTC EPGN HBEGF NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 CD86 EGF CD80 FRS2 FLT3 AREG PPP2R1B PPP2R1A CD19 THEM4 NRG2 NRG3 NRG4 EGFR KLB IRS1 HGF IRS2 PIK3CD FGF1 FGF2 PIK3CB FGF3 PIK3CG NRG1 FGF4 FGF6 PIP5K1C FGF7 FGF9 FGF20 FGF23 PPP2R5E FGF22 GAB2 IRAK1 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A PIK3CA FGF10 PPP2R5D PPP2R5C LCK FYN TRAF6 RHOG PTPN11 PPP2CA PPP2CB INS PIP4K2A MYD88 PIP4K2B PDGFRA PDGFRB TRAT1 PDGFB IRAK4 NTRK3 PIK3AP1 IER3 PHLPP2 PHLPP1 FLT3LG KIT IL33 RAC2 IL1RL1 ESR1 ESR2 PTEN AKT2 AKT3 AKT1 ERBB2 STRN TRIB3 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR CD28 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains CD4 HLA-DRB3 HLA-DRB1 CD3G CD3E CD3D TRAV19 HLA-DPA1 HLA-DRA TRBC1 HLA-DQB2 HLA-DQB1 TRBV12-3 TRBV7-9 PAG1 PTPRC LCK TRAV29DV5 HLA-DQA2 PTPN22 HLA-DRB5 TRAV8-4 HLA-DRB4 HLA-DPB1 CSK PTPRJ TRAC SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants STAT3 HRAS PDGFRA SOS1 PIK3R2 PIK3CA PIK3R1 PIK3CB NRAS STAT1 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia ARG1 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation HMOX1 SLCO1B1 SLCO1B3 ABCG2 UGT1A1 ABCC2 FABP1 UGT1A4 GSTA1 ALB ABCC1 HMOX2 BLVRB BLVRA METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD17B1 CGA LHB STS FDX1 FDXR HSD11B1 FDX2 HSD11B2 AKR1B15 HSD17B14 SERPINA6 HSD17B11 HSD17B2 HSD17B3 SRD5A3 HSD17B12 STARD3 HSD3B2 STARD4 CYP11B2 STAR CYP21A2 STARD6 HSD3B1 STARD3NL TSPO CYP11B1 AKR1B1 CYP11A1 TSPOAP1 POMC SRD5A2 SRD5A1 CYP17A1 CYP19A1 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R40 TAS2R8 TAS2R41 SCN9A TAS2R43 SCN1B TAS2R46 GRM4 TAS2R1 TAS2R30 CALHM3 PLCB2 TAS2R3 TAS2R31 TAS2R5 TAS2R4 TAS2R38 TAS2R39 SCN3A ITPR3 TAS1R2 TAS2R50 TAS1R1 GRM1 SCN2A TAS1R3 SCN2B TRPM5 TRPM4 SCN4B GNG13 TAS2R20 GNB1 GNAT3 TAS2R10 CALHM1 TAS2R13 GNB3 TAS2R14 TAS2R7 TAS2R16 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 CUL1 UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B HES5 HEYL NOTCH1 RBX1 HDAC1 HEY1 HDAC4 HEY2 MIB2 SNW1 JAG2 JAG1 CDK8 ADAM10 DLL1 MIB1 DLL4 NEURL1B ADAM17 NEURL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 MYC HES1 EP300 TBL1X RBPJ HDAC5 HDAC2 CREBBP HDAC8 HDAC9 NCOR1 HDAC6 TBL1XR1 HDAC7 SKP1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PPIE ERCC4 ERCC1 ERCC5 UBA52 USP7 UBB UBC RPS27A ERCC6 RBX1 TCEA1 XAB2 CUL4A CCNH DDB1 POLR2A POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 POLK POLE AQR ERCC8 RFC5 RFC3 RFC4 RFC1 RFC2 PRPF19 ISY1 PCNA POLD3 POLD4 POLD1 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 XPA RPA3 POLE2 POLE3 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction ATM ACD ATR H2AX SPAM1 SUN2 H3-3B SYCP2 SYCP1 SYNE2 H3C8 SYNE1 SUN1 TEX12 TERF1 TERF2 SMC1B H2AJ SYCE3 SYCE2 SYCE1 POT1 TERF2IP REC8 STAG3 SYCP3 CATSPER1 CATSPER3 H3C15 CATSPER2 CATSPER4 HVCN1 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 H2BC9 H3-4 H2BC8 ADAM30 ADAM2 H2BC5 ACR NANOS3 KCNU1 H2BC3 CBFA2T2 CATSPERB CATSPERD CATSPERG H2BC1 CD9 ZP1 ZP3 CDK4 ZP2 ZP4 CDK2 H2AB1 SMC3 H2AC8 H2AC6 H2AC7 B4GALT1 PRDM1 RAD21 STAG1 H2BC26 H2BC21 BMP4 STAG2 H2BC17 H2BC12 H2BC13 H2BC14 TFAP2C H2BC15 FKBP6 SMC1A H2BC11 TET2 HSPA2 H2AZ2 PDPN NANOG POU5F1 SPO11 TEX15 MSH4 DMC1 MSH5 PSMC3IP LMNB1 MND1 MLH3 MLH1 UBE2I MRE11 BRCA1 BRCA2 FIRRM PRDM9 NBN H2AC19 H2AC14 H2BC12L EOMES CXCR4 TOP3A SOX17 RAD51C BLM FIGNL1 RBBP8 H4C9 TINF2 RPA1 RPA2 RAD50 RAD51 H2AC20 RPA3 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RUNX3 MDM2 PSMA7 CBFB PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TGFB1 PSMB3 SRC UBC PSMB1 RPS27A ADRM1 SEM1 EP300 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SMURF2 SMURF1 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 STAT3 NTRK1 NGF SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 RPS27A RPL4 SEPHS2 RPL5 SECISBP2 RPL30 EEFSEC RPL3 SEPSECS RPL32 PSTK RPL31 RPL34 SARS1 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A4 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A10 SLC39A2 SLC39A1 SLC39A14 SLC39A3 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants ITGA2B FN1 SRC ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B YWHAB MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport SERPINA1 PPP6C GOSR1 TFG PPP6R1 PPP6R3 TMED2 ARF4 CTSC TRAPPC2L LMAN1L ANK2 ANK3 F5 ANK1 F8 TRAPPC6A TBC1D20 ACTR1A TRAPPC6B GORASP1 PREB GOLGB1 SEC22B SPTBN4 SEC22A SPTBN5 SEC22C SPTA1 RAB1A TMED10 LMAN2L SPTBN1 COPZ2 STX17 SPTBN2 COPZ1 GOSR2 RAB1B USO1 SCFD1 LMAN2 CD59 SEC31B SEC31A ANKRD28 TRAPPC2 TRAPPC3 SEC16B TRAPPC1 TGFA SEC16A TRAPPC10 TRAPPC4 TRAPPC5 TRAPPC9 SPTAN1 SEC23IP CNIH1 SPTB KDELR3 CNIH2 CNIH3 DCTN1 FOLR1 BET1 ARF1 CTSZ BET1L AREG SEC23A NSF SAR1B GRIA1 DCTN2 DCTN3 SEC24B DYNC1LI1 SEC24A DYNC1LI2 GBF1 TMED3 SEC24D TMED7 SEC24C TMED9 SEC13 COPG2 COPG1 COPB2 COPA COPB1 DYNLL1 TMEM115 COL7A1 COPE DYNLL2 ARFGAP1 DYNC1I2 ARFGAP3 COG8 COG7 COG6 COG5 COG4 INS COG3 COG2 COG1 DYNC1I1 NAPA DYNC1H1 NAPB DCTN6 LMAN1 GOLGA2 DCTN5 NAPG STX5 DCTN4 YKT6 CAPZA3 ACTR10 CAPZB CAPZA1 CAPZA2 ARF5 ARCN1 CSNK1D CD55 KDELR2 MIA3 ARFGAP2 KDELR1 MIA2 ARF3 MCFD2 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors TBXA2R PTGFR PTGIR PTGER4 PTGDR2 PTGER2 PTGER3 PTGER1 PTGDR CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine MAOA TOMT SLC6A3 COMT ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex MCM6 MCM2 H2AX ANAPC15 ANAPC16 KPNA1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 H3-3B CDC16 ANAPC4 ORC5 H3C8 ANAPC5 ORC4 ANAPC1 ORC6 ANAPC2 ORC1 MCM8 H2AJ ORC3 ORC2 H3C15 FZR1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AB1 H2AC8 H2AC6 H2AC7 CDC6 KPNB1 H2BC26 H2BC21 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 H2AZ2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB GMNN PSMB2 KPNA6 PSMB3 UBC PSMB1 RPS27A CDT1 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L H4C9 MCM7 H2AC20 MCM3 MCM4 MCM5 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP16 DUSP6 DUSP7 JAK2 PEA15 IL6 TYK2 JAK1 MAPK1 CDK1 MAPK3 MAP2K1 MAP2K2 IL6R DUSP10 DUSP5 DUSP2 DUSP1 PTPN11 DUSP4 DUSP8 DUSP9 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors HCAR2 HCAR3 HCAR1 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling PTPRZ1 MDK ALK PTN PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression SLC27A1 CCNC PPARGC1B CYP1A1 AHRR MED9 CDK19 ACADM MED16 MED15 MED17 MED12 MED14 MED13 MED10 UGT1A9 HMGCS1 SREBF2 MTF1 MED27 MED26 ESRRA G0S2 FHL2 MED23 MED25 FADS1 MED24 TNFRSF21 MED20 FDFT1 CDK8 ABCB4 RXRB NFYA NFYB NFYC ANKRD1 SP1 GRHL1 HDAC3 SMARCD3 ACSL1 CHD9 PEX11A CPT2 NPAS2 HELZ2 TGS1 EP300 TBL1X PPARGC1A NCOA1 MED1 NCOA2 CREBBP NCOA6 APOA1 NR1D1 NCOR1 NR1H4 TBL1XR1 PLIN2 CARM1 CYP7A1 BMAL1 CLOCK TXNRD1 ALAS1 TIAM2 SULT2A1 HMGCS2 APOA2 APOA5 MED8 ANGPTL4 MED4 MED6 MED7 ARNT2 ABCA1 RGL1 MED30 NR1H3 MED31 FABP1 NR1H2 RORA CPT1A RXRA PPARG AGT PPARA CD36 MED19 MED18 THRAP3 MED11 MED29 FAM120B MED28 NCOR2 MED22 MED21 GPS2 TRIB3 ARNT CYP4A11 MED13L ME1 NCOA3 GLIPR1 NRF1 AHR TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NCBP1 NCBP2 CPSF1 CPSF3 EIF4E CPSF2 WDR33 NUP37 FIP1L1 SYMPK NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 SLBP THOC6 SRRM1 DDX39A NUP107 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 NUP160 CHTOP ALYREF UPF3B MAGOHB NXF2B NUP85 CPSF4 RNPS1 SEC13 NUP133 NUP205 POM121 NUP188 AAAS VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 THTPA SLC19A3 SLC19A2 TPK1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism ASAH2 STS ARSA NEU2 NEU3 GALC SUMF2 SUMF1 HEXB NEU1 HEXA SMPD3 GLB1L3 SMPD2 CTSA GLB1L2 ARSL GLB1L ASAH1 GLB1 GBA3 ARSJ GBA2 GM2A ARSK ARSH ENPP7 ARSI ARSF ARSB GLA ARSG ARSD PSAP GBA1 SMPD4 SMPD1 M6PR DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b MPI THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex CSNK1E CRY2 CRY1 PER2 PER1 KMT2A PER3 BMAL1 CSNK1D CLOCK NPAS2 CREBBP BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ACADM ECHS1 HADH REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway CHST10 CHST8 MGAT2 CGA FUCA1 FUT3 LHB FUT8 MAN2A1 MAN2A2 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants SOS1 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS ERBIN PLCG1 EGF ERBB2 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking CFTR GOPC DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a MGAT2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism ALDOB PPP2CA POM121C ALDOA PPP2CB NUP42 NUP62 NUP43 TPR NUP88 RAE1 PFKL NUP214 RANBP2 GNPDA1 PRKACG NDC1 PC NUP210 GNPDA2 NUP155 PRKACB PFKM NUP153 PFKP NUP93 NUP50 NUP35 NUP54 PGK1 NUP37 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK1 GPI NUP107 PGK2 ENO1 GCKR ENO2 SLC37A1 ENO3 ENO4 PPP2R1B PPP2R1A G6PC2 G6PC3 PRKACA G6PC1 GAPDHS GCK ADPGK HK2 NUP160 HK1 HK3 NUP85 SLC37A4 PCK2 BPGM HKDC1 SEC13 GAPDH NUP133 FBP1 FBP2 PPP2R5D TPI1 PGAM1 PGAM2 PGM2L1 NUP205 POM121 NUP188 ALDOC AAAS REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO NTN1 SLIT1 ROBO1 SLIT3 NELL2 ROBO2 SRC DCC SLIT2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants FLT3 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses IFIH1 PPIH TBK1 TRIM25 FKBP1A PPIG ITCH IRF3 PPIB SIKE1 MAVS UBA52 RIGI NPIPB3 RELA KPNB1 RUNX1 TRAF3 PYCARD UBB TLR7 IKBKE UBC NMI RPS27A TOMM70 NFKB1 NFKBIA CASP1 NLRP3 RIPK3 PCBP2 BST2 IRAK2 SFTPD TKFC TRAF6 RCAN3 PPIA KPNA2 STING1 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state PSMA5 PSMA6 ITCH PSMA3 PSMA4 PSMA1 PSMA2 CUL3 UBA52 PSMD12 PSMD11 GLI1 CDC73 PSMD14 KIF7 PSMD13 GPR161 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 HHIP PSMC4 BOC SPOP PSMC1 GAS1 PSMC2 CDON IHH NUMB SHH SMURF2 SMO SMURF1 GLI3 GLI2 DHH GRK2 CSNK1A1 KIF3A ARRB1 PTCH1 SUFU ARRB2 ULK3 PSMD8 DZIP1 SPOPL PSMD6 EVC2 PSMD7 IQCE EFCAB7 PSMD2 PSMD3 EVC PSMD1 DRC4 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis PPP2CA PPP2CB PTPN6 CALM1 KCNMB1 KCNMA1 LRP8 PDE2A PAFAH2 PTGIR PDE11A GUCY1B2 PDE10A GUCY1B1 NOS3 GUCY1A2 GNGT1 GUCY1A1 GNGT2 P2RX6 P2RX5 NOS2 P2RX3 P2RX2 P2RX1 MAPK14 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PPP2R1B PPP2R1A NOS1 PDE1B PRKG2 PDE1A PLA2G4A STIM1 ORAI2 ORAI1 GNG10 GNG3 ITPR1 GNG2 ITPR2 PECAM1 GNG5 ITPR3 GNG4 GNG7 SRI GNG8 ATP2B4 ATP2B3 PPP2R5E ATP2B2 ATP2B1 APOB SLC8A3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TRPC7 TRPC6 FGR TRPC3 PDE5A KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 IRAG1 P2RX7 GNB2 PDE9A P2RX4 GNB1 GNAS GNB4 GNB3 PTPN11 GNB5 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LIPC LDLR LDLRAP1 APOE TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation TNF CCNC RELA MED9 MED8 ANGPTL4 MED4 MED6 CDK19 MED7 CEBPB NFKB1 LPL MED16 MED15 MED17 MED12 CCND3 MED14 MED13 MED30 MED10 PCK1 MED31 FABP4 SREBF2 CDK4 MED27 NR2F2 MED26 PLIN1 RXRA MED23 MED25 MED24 MED20 PPARG PPARA CDK8 CD36 CEBPD EBF1 MED19 EGR2 ADIRF MED18 THRAP3 MED11 ZNF638 MED29 FAM120B MED28 NCOR2 ZNF467 ADIPOQ MED22 LEP MED21 HDAC3 SMARCD3 CHD9 TGFB1 HELZ2 WNT1 TGS1 WNT10B EP300 TBL1X PPARGC1A NCOA1 MED1 NCOA2 SLC2A4 CREBBP NCOA6 MED13L NCOR1 NCOA3 TBL1XR1 CARM1 CEBPA KLF5 KLF4 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor GNGT1 GNG10 GNGT2 PTGIR GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNAS GNG8 GNB4 GNB3 GNB5 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway LIG1 POLE PARG RFC5 RFC3 ADPRS RFC4 RFC1 RFC2 FEN1 PCNA POLD3 POLD4 POLD1 POLD2 PARP1 PARP2 POLB APEX1 RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs MYCN TNRC6A TNRC6B MYC MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6C CDH1 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization DKK2 EZH2 H2AX ASH2L SMARCB1 MYOG CHD8 MYOD1 TCF4 EPC1 JMJD6 H3-3B SMARCC1 SMARCC2 H3C8 KDM6B H2AJ CTNNB1 H3C15 BICRAL BICRA BRD9 SUZ12 H2BC9 H2BC8 H2BC5 ZMYND8 PCK1 H2BC3 CHD5 IKZF1 RIOX2 IKZF2 SMARCA2 SMARCA4 PHF6 H2BC1 IKZF3 ZNF687 TCF19 ZNF592 ZNF827 MBD2 NR2F2 H2AB1 CDK2AP2 CDK2AP1 PWWP2B ZNF532 MBD3L2 MBD3L1 H2AC8 PWWP2A H2AC6 H2AC7 PBRM1 KMT2A KMT2C BRWD1 SNRPD2 ATF2 SNRPD1 NFKB2 SNRPD3 PRMT5 WDR77 HDAC3 SNRPG SMARCD3 CHD9 SNRPE ARID2 SNRPF DPY30 SNRPB H2BC26 H2BC21 WDR5 EP300 EED TBL1X H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 H2BC15 NCOA2 CREBBP H2BC11 NCOR1 TCF3 TBL1XR1 CARM1 MAFK CHD4 RBBP4 CHD3 RBBP5 CLOCK NFE2L2 RBBP7 H2AZ2 AXIN2 H2BC18 MTA2 REST PHF20 DNMT3A SUPT16H TAF9 KDM4C PAX3 TAF12 TAF10 SSRP1 HDAC1 BCL11B SETD1B SETD1A PHF10 KDM5A ACTB KDM6A PADI2 ING5 BRD1 TCF12 NCOR2 KAT2B KAT2A ATXN7 IGF2 GPS2 BRD7 KDM4A HCFC1 ADNP2 KDM1A ADNP CHD1 DHX15 KDM3A KDM1B KDM4B ARID4A ARID4B MEAF6 SAP30 YEATS4 BRMS1 PHF21A SUDS3 RCOR1 DDX46 DDX42 RBM17 HMG20B SAP30L TADA2B SMNDC1 SAP18 U2SURP KAT6A JADE1 JADE3 JADE2 KAT7 SUPT20H SF3B4 ATXN7L3 SF3B5 SF3B2 SUPT7L SF3B3 MORF4L1 SF3B6 KAT6B SF3B1 MORF4L2 SF3A3 HAT1 SF3A1 CCND1 ENY2 SF3A2 TAF5L DMAP1 PHF5A MRGBP TADA1 ING4 ING3 VPS72 MSL2 MSL3 SUPT3H SNRPN ACTL6B CDK4 MSL1 TAF6L CHERP ACTL6A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 SNRPA1 PUF60 SNRPB2 KAT8 MBD3 MBIP KAT14 DR1 TADA2A ZZZ3 GATAD2B GATAD2A YEATS2 TADA3 SGF29 CHD7 NKD2 FBP1 FAM124B SMARCD1 KANSL1 HDAC2 KANSL2 SMARCD2 KANSL3 RUVBL1 CBX1 HDAC8 SMARCE1 KMT5A MCRS1 RPS2 USP22 PHF2 KDM5C HDAC10 KDM3B KDM5D PHF8 UTY KDM2A OGT KDM2B PADI3 CDC73 KDM4D PADI4 ARID5B PADI1 PADI6 RELA SKIC8 CTR9 RTF1 CHD2 LEO1 PRMT6 KMT2D NFKB1 PAF1 PRMT1 KMT2B MTA1 PRDM16 MTA3 UBE2I SMYD2 CBX3 SUMO1 BCL7A KDM7A BRPF1 BCL7C DPF1 BRPF3 BCL7B DPF2 NSD2 DPF3 G6PC1 KDM5B SS18 SS18L1 KAT5 SUV39H2 SETD2 H2AC17 SETD3 H2AC12 PRDM9 SETD6 PRMT7 SUV39H1 PRMT3 RUVBL2 ARID1A DOT1L H2AC1 ARID1B SETD7 COPRS H2AC19 H2AC25 NSD3 H2AC14 H2AC21 MECOM H2BC12L NSD1 KMT5B SMYD3 NR2C2 ATF7IP SETDB1 BCL11A KMT5C SETDB2 ASH1L AEBP2 SAP130 NQO1 EHMT2 JAK2 EHMT1 CTCF CHD6 H4C9 TRRAP EP400 H2AC20 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse MYH9 MYL12B NGEF MYH11 LYN YES1 MYH14 MYH10 FYN MYL6 RHOA ROCK1 MYL9 ROCK2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide UBE2D1 RCHY1 RPL4 NPLOC4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 UBE2D2 RPL18A RPL36AL RPL36 RPL35 RPL38 RPL37 RPL39 RPL21 VCP RPL23 RPL22 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPL39L RPL41 RPL3L RPL27A RPLP1 RPLP0 ANKZF1 RPL7A KLHDC10 RPLP2 TCF25 NEMF RPL13A PSMD8 RPL37A PSMD6 RPL10 PSMD7 RPL12 PSMD2 RPL11 PSMD3 RPL36A PSMD1 RPL14 RPL13 RPL15 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 PSMD12 PSMD11 ELOB RPL26L1 PSMD14 PSMD13 ELOC PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LTN1 CUL2 UFD1 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription NR3C1 REST SRF KCNIP3 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly CEP83 DYNLRB2 DYNLRB1 IFT25 CEP89 CEP57 ARF4 C2CD3 CETN2 PLK1 CEP164 PKD2 PKD1 IFT52 ACTR1A PCM1 TCTN3 TCTN2 CNTRL TCTN1 CNGA2 CDK1 BBS9 CNGA4 BBS7 TNPO1 IFT57 CEP290 NINL IFT56 BBS5 CC2D2A BBS4 RAB8A OFD1 DYNLT5 IQCB1 MKKS EXOC8 DYNLT2 IFT140 EXOC7 TUBB HAUS4 HAUS3 KIF24 HAUS6 HAUS5 TUBG1 SSTR3 WDR35 HAUS2 HAUS1 BBS10 IFT43 RP2 BBS12 TMEM216 EXOC4 EXOC3 EXOC6 CEP63 EXOC5 NEK2 IFT46 SFI1 EXOC2 SDCCAG8 EXOC1 IFT70B PPP2R1A IFT70A DCTN2 SSNA1 DCTN3 DYNLT2B ASAP1 IFT74 HAUS8 HAUS7 TMEM67 PCNT SEPTIN2 CEP152 WDR19 GBF1 CSNK1E KIF17 SCLT1 RAB11A ATAT1 NEDD1 TTC8 ALMS1 TRIP11 CEP162 B9D1 CEP41 CEP43 CLUAP1 YWHAG ARL13B INPP5E PDE6D DYNLL1 HSP90AA1 CKAP5 DYNLL2 HDAC6 MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 YWHAE DYNC1H1 NDE1 RHO B9D2 CNGB1 CPAP SMO AKAP9 PRKAR2B TUBA4A PRKACA DYNC2I2 DYNC2I1 TRAF3IP1 IFT172 CCP110 CEP250 KIFAP3 CEP97 CDK5RAP2 DYNC2H1 CEP135 CEP131 CSNK1D IFT80 CYS1 TUBA1A RPGRIP1L LZTFL1 CCT3 IFT88 CCT2 IFT81 UNC119B ARL6 ARL3 FBF1 MCHR1 TCP1 TTBK2 DYNC2LI1 KIF3B KIF3A TTC21B CEP70 NPHP1 CEP72 NPHP3 CEP192 NPHP4 KIF3C MARK4 CEP76 RAB11FIP3 CCT8 CEP78 PLK4 CCT5 BBS2 CCT4 BBS1 ODF2 RAB3IP TUBB4B IFT122 TUBB4A BBIP1 IFT20 AHI1 IFT22 MKS1 IFT27 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control MRPS12 MRPL38 MRPS10 MRPL39 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MALSU1 MRPS18A MIEF1 MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPL46 MRPS6 MRPS5 MTRFR MRPL43 MTRES1 MRPL44 MRPS18C MRPL52 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 PLCG1 NGF TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL2 RHOC RAC1 SEMA4D LIMK2 LIMK1 RRAS MYH14 CDK5 MYH10 PLXNB1 DPYSL4 DPYSL5 CDK5R1 DPYSL3 PLXNC1 SEMA6A SEMA6D SEMA7A PAK1 MET MYL12B PLXNA2 PLXNA3 PAK3 PTPRC FES PAK2 PLXNB3 TREM2 MYH11 SEMA3A SEMA3E FARP2 SEMA4A MYL6 PLXNA4 CD72 SEMA5A TYROBP CFL1 CRMP1 NRP1 GSK3B RHOA HSP90AB1 ERBB2 ROCK1 ROCK2 ARHGEF11 PIP5K1C ARHGEF12 MYH9 RHOB ITGB1 ARHGAP35 RND1 HSP90AA1 ITGA1 PLXNA1 PLXND1 FYN TLN1 MYL9 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 CYP4F22 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling APOA2 APOC2 LPL APOA4 APOB APOA5 GPIHBP1 APOA1 APOE APOC3 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle GLS GAD1 GAD2 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC5A7 SLC1A7 SLC38A2 SNAP25 SYT1 VAMP2 SLC6A12 STX1A CASK HSPA8 LIN7A LIN7C LIN7B ABAT ARL6IP5 UNC13B SLC6A13 SLC6A11 SLC22A2 SLC22A1 SLC6A1 SLC18A2 SLC18A3 SLC32A1 MAOA SYN3 SYN2 SYN1 ALDH5A1 SLC17A7 RAB3A RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 NAAA CHAT CPLX1 DNAJC5 GLS2 TSPOAP1 APBA1 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation NOSTRIN DNM2 NOS3 NMT1 CALM1 NOSIP WASL NMT2 CYB5B HSP90AA1 LYPLA1 CYGB DDAH1 ZDHHC21 CAV1 SPR AKT1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion FFAR1 GNA11 GNAQ GNA14 PLCB3 GNA15 PLCB1 PLCB2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PSMA5 BUB3 PSMA6 PSMA3 ANAPC15 PSMA4 ANAPC16 ANAPC7 PSMA1 PSMA2 UBE2C UBA52 UBE2E1 UBE2D1 PSMD12 PSMD11 ANAPC10 PSMD14 ANAPC11 PSMD13 CDC23 UBE2S CDC26 PSMA7 CDC27 CDC16 PSMB6 CDK1 ANAPC4 PSMB7 ANAPC5 PSMB4 ANAPC1 PSMB5 ANAPC2 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC MAD2L1 PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEK2 BUB1B CDC20 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 M PHASE%REACTOME%R-HSA-68886.5 M Phase H2AX ANAPC15 CEP57 ANAPC16 ANAPC7 CETN2 UBE2C PLK1 CEP164 UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A PCM1 CCNB1 GORASP1 CDC23 UBE2S CDC26 CNTRL CDC27 H3-3B ARPP19 CDC16 RAB1A NCAPH2 CDK1 NCAPG2 H3C8 ANAPC4 NIPBL ANAPC5 ENSA ANAPC1 TNPO1 NCAPD3 ANAPC2 RAB1B H2AJ USO1 RAB2A CEP290 NINL CTDNEP1 BLZF1 CNEP1R1 MAU2 MASTL GORASP2 OFD1 MCPH1 PPP2R2D H3C15 TUBB HAUS4 KIF20A HAUS3 H2BC9 HAUS6 H3-4 H2BC8 HAUS5 TUBG1 H2BC5 H2BC3 HAUS2 MAPK1 HAUS1 H2BC1 SET KIF23 CEP63 H2AB1 NEK2 SFI1 H2AC8 SDCCAG8 H2AC6 H2AC7 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PCNT CEP152 CSNK1E NEDD1 ALMS1 CEP41 CEP43 XPO1 H2BC26 H2BC21 YWHAG H2BC17 H2BC12 H2BC13 ANKLE2 H2BC14 H2BC15 PTTG1 H2BC11 EMD H2AZ2 LEMD3 RCC1 YWHAE LMNB1 GOLGA2 SMC4 SPAST SMC2 CC2D1B SIRT2 TUBGCP2 NCAPG TUBB8 NCAPH IST1 VRK1 TUBGCP5 LEMD2 TUBGCP6 TUBB8B TUBGCP3 TUBGCP4 ESPL1 NUMA1 TUBG2 MZT2B MZT2A NME7 MZT1 NCAPD2 TUBB6 TUBB3 TUBB1 LPIN1 LPIN2 LPIN3 PRKAR2B TUBA4B PPP2R2A TUBA4A TUBA8 TUBA1C TUBA1B TUBA1A FBXO5 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR BANF1 NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NEK9 NEK6 NEK7 RB1 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 KPNB1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 LBR KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 HSP90AA1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 CHMP4A BIRC5 PSMD8 KIF2C CHMP6 KIF2B CHMP7 PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA KMT5A AURKB NSL1 CENPC PPP2CA PRKCB PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CHMP2B CLASP1 PSMA4 DYNC1I1 CHMP2A PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 RAN NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 CPAP PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2I SUMO1 AKAP9 PRKACA PRKCA FIRRM CCP110 CEP250 H2AC19 CDK5RAP2 H2AC14 H2BC12L CEP135 EML4 CEP131 CSNK1D CSNK2A1 CSNK2A2 CSNK2B CEP70 CEP72 VPS4A CEP192 CEP76 CEP78 PLK4 H4C9 ODF2 H2AC20 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 PNRC2 EIF4G1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 PPP2R1A RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 RPL13A RPS3A RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 PPP2CA RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A UBA52 RPL22L1 FAU RPL26L1 NCBP1 NCBP2 UPF1 RPS27A EIF4A3 CASC3 MAGOH PPP2R2A RBM8A GSPT2 GSPT1 UPF3B UPF3A MAGOHB RNPS1 UPF2 PABPC1 DCP1A ETF1 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJA10 GJA3 GJA5 GJA4 GJA9 GJA8 GJC2 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GJD4 GJB2 GJD3 GJB1 GJC1 GJD2 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs TNRC6A TNRC6B AGO3 AGO4 AGO1 AGO2 TNRC6C NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 NEURL1 MDK UBB PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A APH1B CNTN1 NOTCH2 MIB2 NOTCH2NLA NOTCH2NLC NOTCH2NLB BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade PPP2CA PPP2CB CTNNB1 PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B FRAT1 FRAT2 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ERCC6L NUP107 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA8 PMF1 NUP160 SKA1 SKA2 DSN1 NUP85 RCC2 NDC80 ZWINT XPO1 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 BUB3 BUB1 CLASP1 DYNC1I1 CLASP2 RANBP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 MAD2L1 CENPS NUP37 SPC25 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G3 PLA2G4B PLA2G6 PLA2G2A PLA2G4F PLA2G4E LPCAT4 PNPLA8 PLA2G10 PLA2G4C MBOAT2 PLAAT3 PLA2R1 LPCAT3 PLBD1 PLA2G4A ABHD4 PLAAT1 PLAAT2 PLAAT5 PLA2G1B PLAAT4 PLA2G5 MBOAT1 PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA2G4D DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 OGG1 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism ENPP1 RFK SLC52A2 SLC52A3 SLC52A1 FLAD1 ACP5 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME CYP3A4 SLCO1B1 SLCO1B3 UGT1A3 PON3 ABCC2 ABCB1 PON1 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells FGF10 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF EP300 CBFB RUNX1 KRAS TGFB1 BRD2 CCND1 HDAC4 RUNX3 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance HDLBP PCSK9 AP2A1 LIPA AP2A2 LIPC UBA52 LDLRAP1 AP2M1 MYLIP CUBN VLDLR AMN LSR NPC1 SOAT1 SOAT2 UBB NPC2 UBC RPS27A CES3 APOB AP2S1 LDLR CLTC CLTA APOC4 NR1H3 APOE APOA1 APOBR AP2B1 NCEH1 NR1H2 APOC1 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system B2M TLR2 UBB MRC1 UBA52 UBC RPS27A WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis AWAT1 FAR1 FAR2 AWAT2 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System CHUK BTK S100A1 CD36 TIRAP F12 KLKB1 NFKB2 MYD88 RELA TICAM1 UNC93B1 LY96 TRAF3 CD14 TLR7 TLR3 HMGB1 NFKB1 IRAK4 NFKBIA TLR1 TLR10 TLR6 TLR5 TLR2 S100A9 S100A8 FGB FGA FGG IKBKB F2 TLR4 IKBKG SERPING1 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins FIP1L1 WDR48 STRN REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling CHUK TBK1 MAPKAPK2 TNF UBA52 STUB1 UBE2D1 TNFRSF1A RBCK1 SPPL2B USP2 SPPL2A UBB CLIP3 IKBKE TAX1BP1 OPTN UBC OTULIN RPS27A TRADD UBE2L3 CASP8 RACK1 TRAF2 UBE2D2 RNF31 MIB2 TNFAIP3 UBE2D3 SPATA2 OTUD7B IKBKB SHARPIN USP21 BIRC2 USP4 BIRC3 TRAF1 XIAP CYLD OTUD1 RIPK1 IKBKG FADD ULK1 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation AMT GLDC GCSH DLD OGDH DLST KGD4 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 TP53 PSMD12 PSMD11 COP1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA LTV1 RRP1 FCF1 THUMPD1 PWP2 RRP9 IMP3 WDR75 IMP4 SNU13 SET RRP7A ANP32A PDCD11 ERI1 TNFSF13 GAR1 ELAVL1 DHX37 PNO1 TBL3 LAS1L MPHOSPH10 NOL11 NOL12 NAT10 WDR46 WDR43 RIOK2 RIOK1 UTP14A UTP14C WDR36 TEX10 GNL3 NIP7 TSR3 HEATR1 GEMIN2 PHAX NOL9 NOC4L SNRPD2 SNRPD1 NOL6 EXOSC10 SNRPD3 PRMT5 PES1 WDR77 RRP36 CLNS1A UTP6 UTP4 SNRPG RIOK3 GEMIN4 UTP3 GEMIN5 WDR18 SNRPE WDR12 GEMIN6 BYSL GEMIN7 SNRPF BOP1 TSR1 GEMIN8 SNRPB MPHOSPH6 RPP30 DDX20 SMN2 FBL SNUPN MTREX RPP38 DIMT1 FTSJ3 EBNA1BP2 DKC1 NHP2 RPP21 RPP25 UTP25 ISG20L2 EMG1 UTP20 ZFP36 NOP14 RPP40 RCL1 NOP10 RBM28 PPIL2 DDX49 DDX47 WDR3 NOB1 BUD23 PELP1 UTP15 UTP11 DDX52 SENP3 UTP18 C1D DDX21 BMS1 RPP14 DCAF13 KRR1 NCBP1 NCBP2 FIP1L1 XRN2 PQBP1 SRRT ZCRB1 SNRNP200 FUS ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 SKIC2 HNRNPA3 GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 SUGP1 DHX15 DHX16 NOP56 NUP205 HNRNPA2B1 POM121 NUP188 WBP11 AAAS POM121C PPIE NUP42 PPIH NUP62 TPR PPIG NUP88 RAE1 DDX46 NUP214 DDX42 NDC1 RBM17 NUP210 FASTKD5 NUP155 TBRG4 SMG1 BUD31 SMG9 NUP153 NUP93 SMG7 SMG8 NUP50 RBM22 SMG5 DDX23 NUP35 SMG6 NUP54 PNRC2 SMNDC1 SAP18 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 SLIRP MTPAP CPSF2 TRMT61B CSTF2T WDR33 LRPPRC NUDT21 HNRNPL PCF11 CLP1 HNRNPM HNRNPK CSTF1 RPL4 PAPOLA RPL5 HNRNPF SYMPK RPL30 HNRNPD RPL3 RPL32 SF3B4 RPL31 SF3B5 RPL34 SF3B2 SF3B3 RPL10L SF3B6 RPL10A RPL8 SF3B1 RPL6 SF3A3 RPL7 SF3A1 SF3A2 XAB2 RPS15 PHF5A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 TXNL4A RPL36AL RPL36 CNOT6L SNRPN RPL35 CHERP RPL38 RPL37 RPS11 RPL39 PTBP1 RPS10 PLRG1 RPS13 SNRPA1 RPS12 RPS9 DNAJC8 RPL21 RPS7 PUF60 RPS8 SNRPB2 RPL23 ZNF473 RPS5 RPL22 PPIL1 RPS6 SNRNP40 RPSA RPL9P9 RPL24 RPL27 RPL26 PPIL3 RPL29 PPIL4 RPL28 SRRM2 TRNT1 RPS4Y2 AQR HSPB1 RPS4Y1 RPL39L CPSF4 WDR82 RPL41 CRNKL1 PDCD7 SNRNP35 SNRNP25 PRPF19 RNPC3 RPL3L RPS26 ZMAT5 ZRSR2 RPS25 SNRNP48 RPS28 RPS29 RPL27A HNRNPH1 RPS20 HNRNPH2 GRSF1 RPS21 RPS24 RPS23 RPLP1 CWC25 CWC27 RPLP0 EFTUD2 CWC22 RPS4X RPL7A PRPF6 RPLP2 PRPF8 CWC15 RPL13A RPS3A RBM5 PSMD8 RPL37A ZFP36L1 PSMD6 RPL10 PSMD7 RPL12 RBM27 PSMD2 RPL11 ZCCHC8 PSMD3 RPL36A ZCCHC7 PSMD1 RPS27L ELAC2 RBM26 RPS15A YTHDC1 ZC3H4 PABPN1 RPL14 ZC3H3 RPS3 YTHDC2 RPL13 TENT4B RPL15 PAPOLG RPS2 ZC3H18 PSMA5 RPL18 RBM7 PSMA6 RPL17 ZFC3H1 PSMA3 DXO PSMA4 RPL19 PSMA1 RPL35A PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 RAN PSMD11 RPL26L1 HSPA1A PSMD14 PSMD13 PSMA7 OSGEPL1 GTPBP3 TRMU PSMB6 SKIC8 PSMB7 YRDC PSMB4 MTO1 PSMB5 METTL14 REXO2 UBB PSMB2 METTL3 PSMB3 PNPT1 UBC SUPV3L1 PSMB1 WTAP RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HNRNPU NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 NOP58 THOC2 THOC5 IGF2BP1 THOC7 CDC40 TENT4A THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 HBS1L NT5C3B RBM8A SKIC3 POLDIP3 SRSF1 DCPS PRKCA U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 ACIN1 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 CSNK1D ADARB1 TNPO1 YWHAB SNW1 MAPK14 MAPK11 MAPKAPK2 CSNK1E TCERG1 SNRPC SRSF8 SNRPA HTATSF1 RBM25 PPP1R10 SNRNP70 PRPF40A TUT1 PPP1R8 XPO1 SRSF10 SRSF12 TGS1 RBM39 CNOT10 CNOT11 ADAR DIS3 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 KHSRP EXOSC8 EXOSC3 EXOSC2 EXOSC1 YWHAZ QNG1 URM1 WDR4 PPP1CB THADA LAGE3 OSGEP THG1L ALKBH8 TYW1 LCMT2 TRMT44 PPP1CA TRDMT1 PUS3 TRMT10A TYW5 METTL1 NSUN2 EPRS1 TYW3 TYW2 TPRKB ADAT1 TRMT1 CDKAL1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 ADAT2 TRMT9B QTRT1 GON7 DUS2 PPP2R2A CTU2 QTRT2 CTU1 TNKS1BP1 TRMT5 TRMT6 TRMT13 TRMT11 TRMT61A GSPT2 GSPT1 DDX6 NCL LSM1 LSM5 LSM4 UPF3A LSM3 PATL1 EDC3 LSM2 UPF2 EDC4 LSM7 TUT7 LSM6 PABPC1 XRN1 TUT4 DCP1A DCP2 DCP1B TRA2B MTERF3 MTERF4 RBBP6 FASTKD2 TFB1M NSUN4 PAIP1 RPUSD4 CPSF7 RPUSD3 PAN2 TRUB2 PAN3 TRMT10C PRORP DDX5 RCC1L ETF1 NGRN MRM1 HSD17B10 MRM2 HNRNPC MRM3 RBMX EIF4E EIF4B EIF4G1 STEEP1 GPATCH1 PNN SF1 DHX8 PRKRIP1 CWF19L2 WDR70 DHX35 PRPF38A SMU1 NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A CACTIN LSM10 PRPF31 SLBP RBMX2 LSM11 SNIP1 IK PRP4K NUP107 LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 YJU2 CNOT4 LSM8 PPP2R1A PPWD1 USP39 CNOT6 SART1 CNOT7 TFIP11 SYF2 CNOT1 C9orf78 CNOT2 LUC7L3 CNOT3 NSRP1 WBP4 RNF113A MFAP1 TRMT112 CNOT8 RBM42 BUD13 FAM50A CNOT9 NUP160 NUP85 RPS27 SEC13 NUP133 APOBEC1 APOBEC3C APOBEC2 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B PPP2CA NUP43 TP53RK RANBP2 UPF1 NUP37 POP5 POP7 TSEN15 POP1 POP4 RTCB ZBTB8OS TSEN2 EIF4A2 TSEN54 EIF4A1 TSEN34 DDX1 C2orf49 RTRAF XPOT FAM98B NOP2 CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 PRKCD GTF2H5 YBX1 CDK7 ERCC3 ERCC2 MNAT1 AKT1 IGF2BP3 IGF2BP2 DDX41 ZNF830 DHX9 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway TNFRSF6B CHUK TNFSF18 FBXW11 TNFSF14 PSMA5 TNFSF15 PSMA6 TNFSF12 PSMA3 UBE2M PSMA4 EDARADD PSMA1 TNF EDAR PSMA2 UBA52 LTA PSMD12 LTB PSMD11 PSMD14 PSMD13 TNFRSF1B CUL1 TNFRSF1A TNFRSF11B TNFRSF11A PSMA7 PSMB6 TNFSF11 PSMB7 PSMB4 TRAF3 PSMB5 UBB PSMB2 CD27 TNFRSF13B PSMB3 TNFRSF13C UBC EDA2R PSMB1 TNFRSF12A RPS27A CD70 ADRM1 EDA SEM1 PSMC5 PSMC6 TNFSF6 PSMC3 PSMC4 TNFSF4 PSMC1 TNFSF9 PSMC2 TNFSF8 LTBR TNFSF13 CD40LG TNFRSF14 NFKB2 MAP3K14 RELB TNFRSF18 TRAF2 PSMD8 TNFRSF8 PSMD6 TNFRSF4 BIRC2 PSMD7 BIRC3 PSMD2 PSMD3 TNFRSF17 PSMD1 TNFRSF9 BTRC TNFSF13B SKP1 TNFRSF25 UBA3 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE ABCC6 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina PRKCB PRKCA CCNB1 LMNB1 CDK1 EMD CTDNEP1 LEMD3 CNEP1R1 LPIN1 LPIN2 LEMD2 LPIN3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion OSGEPL1 HSD17B10 GTPBP3 TRMU YRDC MTO1 TRMT61B TRMT10C PRORP TRIT1 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type MMAB SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants STAT3 HRAS PDGFRA SOS1 PIK3R2 PIK3CA PIK3R1 PIK3CB NRAS STAT1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX5 ALOX15 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling ITGA2B SPRED3 SPRED2 SPRED1 CALM1 FN1 KRAS PAPSS1 NF1 BCL2L11 ATG7 SRC DUSP6 DUSP7 PPP1CB YWHAB MARK3 MRAS NRAS RAP1A MAPK1 SHOC2 HRAS MAPK3 MAP2K1 MAP2K2 TENT4A KIAA1549 MPRIP BRAF TRIM24 AGTRAP AP3B1 SND1 ESRP1 DUSP16 AKAP9 PPP1CC KDM7A FAM114A2 ZC3HAV1 TRAK1 FXR1 LMNA AGK QKI CLCN6 FAM131B AGGF1 CAMK2B CAMK2D CAMK2A CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 CNKSR1 RAF1 TLN1 CSK DUSP10 VCL MAP3K11 DUSP8 DUSP9 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation IDS SDC1 HPSE GPC1 HSPG2 GPC3 IDUA GPC2 SDC4 SGSH SDC2 GPC5 SDC3 GPC4 GPC6 HPSE2 AGRN CTSL NAGLU DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant F9 F8 F10 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling PRKAR2B PRKACA PRKACG ADCY4 PRKACB ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A GNAS ADCY9 PRKAR1B INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling STAT4 JAK1 STAT3 IL12RB2 CANX IL27RA IL12A EBI3 JAK2 IL6ST STAT1 TYK2 PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation FDX1 DBT GCSH NFU1 LIAS NDUFAB1 DLAT LIPT2 LIPT1 DLST TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer TGFBR1 TGFBR2 SMAD2 TGFB1 SMAD3 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism ADH1A MAPDA NT5C2 PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling DDOST APP LGALS3 AGER MAPK1 S100A12 S100B MAPK3 PRKCSH SAA1 CAPZA1 HMGB1 CAPZA2 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage GSDMD CASP3 CASP5 IL18 IL1B SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs HACD3 HACD2 HACD4 ELOVL1 ELOVL5 ELOVL4 ELOVL2 ACSL6 ACSL5 ELOVL3 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ELOVL6 ACSBG1 ACSL1 SLC27A3 ACSBG2 HACD1 TECR HSD17B3 HSD17B12 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes ME1 IDH1 NFE2L2 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PPIE CETN2 LIG1 USP7 ERCC6 XAB2 ACTL6A DDB2 COPS5 AQR ERCC8 PRPF19 UBE2N RUVBL1 NFRKB PARP1 PARP2 ACTR5 USP45 RAD23A CHD1L ACTR8 YY1 RAD23B INO80C INO80B INO80E INO80D XPA COPS7B COPS7A XPC TFPT MCRS1 INO80 COPS3 COPS6 ERCC4 ERCC1 ELL ERCC5 COPS8 UBA52 RNF111 UBB UBC RPS27A RBX1 TCEA1 PIAS3 UBE2I ACTB XRCC1 LIG3 CUL4A CCNH DDB1 POLR2A PIAS1 POLR2B CUL4B POLR2C POLR2D POLR2E POLR2F SUMO1 POLR2G SUMO3 POLR2H SUMO2 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 POLK POLE RFC5 RFC3 RFC4 RFC1 RFC2 UBE2V2 ISY1 GPS1 PCNA POLD3 POLD4 COPS4 COPS2 POLD1 POLD2 ZNF830 UVSSA RPA1 RPA2 POLE4 RPA3 POLE2 POLE3 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription EZH2 H2AX ASH2L JUN TEAD1 TEAD2 TEAD3 H3-3B RELA TEAD4 H3C8 FOS H2AJ YAP1 NFKB1 CTNNB1 H3C15 BRD4 SUZ12 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 H2BC1 FOSB H2AB1 H2AC8 H2AC6 H2AC7 MYCN KMT2A KMT2C TCF7 NFKB2 H2AC19 H2AC14 H2BC12L MYC DPY30 H2BC26 H2BC21 WDR5 EP300 EED ATF3 H2BC17 EPAS1 H2BC12 H2BC13 H2BC14 H2BC15 HIF1A CREBBP IRF1 H2BC11 LEF1 WWTR1 H4C9 RBBP4 RBBP5 JUND RBBP7 NFE2L2 TCF7L2 H2AZ2 TCF7L1 H2AC20 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease POLR2I POLR2J POLR2K POLR2L FGFR2 SOS1 GTF2F1 GTF2F2 NCBP1 NCBP2 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 PIK3R1 PIK3CA FGF10 NRAS GAB1 HRAS PLCG1 POLR2A POLR2B FRS2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GP5 F11 GP1BA F9 GP9 GP1BB GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling PRKAR2B PRKACA PRKACG GNAI3 ADCY4 PRKACB ADCY3 GPER1 ADCY2 ADCY1 ADCY8 ADCY7 GNG10 ADCY6 GNG3 PRKAR2A GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 GNG8 PRKAR1A SRC GNAZ ITGB1 ITGA5 GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNAT3 GNAS GNB4 GNB3 GNB5 ADCY9 PRKAR1B SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGX PIGC PIGB DPM2 PIGA PIGM PIGL PIGG PIGF PIGH PIGO PIGN PIGP PIGZ PIGW PIGV PIGY SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 FGF9 FGF20 HRAS FGF23 FGF16 SOS1 FGF18 FGF1 FGF2 FGF4 NRAS NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 SGCE LAMA4 LAMA3 SNTG2 SGCD LAMC2 SGCA SGCB LAMB1 LAMC1 DMD SGCG VTN SNTA1 DTNA DTNB SGCZ SSPN SNTB1 SNTB2 AGRN ITGB5 PDGFB DDR1 UTRN TRAPPC4 NTN4 DDR2 TTR PDGFA TNC DRP2 CASK ITGAV DAG1 PRKCA HSPG2 SDC4 SDC2 SDC3 THBS1 TGFB1 FGF2 SDC1 ITGB1 ITGB3 ACTN1 ITGB4 NRXN1 ITGA2 ITGA6 LAMA5 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ATM ZNF420 AIFM2 BNIP3L BBC3 TP63 TP53AIP1 BAX PRELID1 TP53 STEAP3 CREBBP TP53INP1 PRELID3A PPP1R13B TP53BP2 BID TP73 TRIAP1 PMAIP1 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants FLT3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 PPP2CA PPP2CB PPP2R1B PPP2R1A PPP2R2A UBA52 CDK7 CUL1 MNAT1 RBL2 RBL1 UBB UBC RPS27A CDKN1C RB1 CDKN2D PTK6 CDKN1A CDKN2B CDKN1B CKS1B CDKN2C CCND3 CDKN2A CCND2 CCND1 JAK2 E2F1 E2F2 ABL1 E2F3 E2F4 SKP2 LYN E2F5 PPP2R3B CDK6 TFDP1 CCNE2 CCNH TFDP2 CDK4 CCNE1 CDK2 SKP1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA AURKA PHLDA1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome RB1 ZCRB1 VHL DDX5 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism ACER2 ACER1 ALDH3B1 ACER3 PLPP3 PLPP2 PLPP1 ALDH3B2 SGPP2 SGPL1 SGPP1 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm CTNNB1 NOTO TCF7 FOXA1 FOXA2 TEAD2 LEF1 SHH FOXH1 TEAD4 SMAD2 SMAD3 YAP1 TBXT ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria YWHAG YWHAZ PPP3CC YWHAE SFN YWHAB BID AKT2 YWHAH BCL2 YWHAQ AKT3 BAD AKT1 PPP3R1 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly MTTP APOB PRKACA A2M PRKACG ABCA1 APOC4 PRKACB APOA1 APOE APOC3 APOA2 APOA4 APOC2 APOC1 P4HB ZDHHC8 SAR1B SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 GZMB JAG2 JAG1 ADAM10 DLL1 MIB1 DLL4 NEURL1B UBA52 MAML2 MAML1 NEURL1 MDK FCER2 MAMLD1 UBB PSENEN PSEN2 PSEN1 UBC APH1A HES1 NCSTN RPS27A APH1B HES5 CNTN1 NOTCH2 EP300 RBPJ MIB2 NOTCH2NLA NOTCH2NLC NOTCH2NLB SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBA52 TSG101 NMT2 MVB12B MVB12A VPS37C VPS37D VPS37A VPS37B UBAP1 UBB VPS28 UBC RPS27A REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome RB1 ZCRB1 VHL DDX5 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t PGM1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity TNRC6A TNRC6B CCND3 CCND2 CCND1 CBFB CDK6 RUNX1 MOV10 AGO3 SRC AGO4 PTPN11 AGO1 AGO2 PML TNRC6C PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 FGF9 FGF20 FGF23 FGF16 PLCG1 FGF18 FGF1 FGF2 FGF4 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis PMVK FDFT1 FDPS IDI2 ACAT2 PLPP6 SQLE GGPS1 HMGCS1 LSS MVD IDI1 MVK DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 PROS1 PROC F5 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 SLC27A4 LCN15 LCN12 APOD SLC27A6 LCN9 LCN1 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f MPDU1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g ALG12 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters MTERF1 TFAM POLRMT TFB2M CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress EIF2S3 EIF2AK1 YME1L1 EIF2S2 EIF2S1 STOML2 OMA1 PHB2 DELE1 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNAR1 FURIN CCNC GPC1 TYK2 GPC3 JAK1 GPC2 GPC5 GPC4 STAT2 GPC6 MED9 MAP1B AGRN CDK19 MED16 MED15 MED17 MED12 MED14 IFNB1 MED13 MED10 CLEC4M MED27 MED26 HSPA8 MED23 MED25 MED24 PPP1CC MED20 CDK8 IRF3 SEC11A SEC11C EGFR KPNB1 LY96 EIF2AK2 ISG15 XPO1 CD209 EP300 TLR6 TLR2 SPCS3 SPCS2 SPCS1 MED1 H2BC15 CREBBP HSP90AA1 OAS2 TLR4 UBE2L6 HERC5 UBA52 ELOB BECN1 ELOC UBB CD14 MED8 UBC MED4 MED6 RPS27A MED7 RBX1 PPP1CB MED30 PPP1CA MED31 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IFIH1 TRIM25 IFNA21 IFNA14 IFNA16 IFNA17 MAVS IFNA10 MED19 RIGI MED18 MED11 HSPG2 MED29 CX3CR1 RAB5B MED28 RAB5C MED22 IGF1R MED21 NCL SDC4 SDC2 RAB5A SDC3 TLR7 TLR3 HSP90AB1 CSNK2A1 CSNK2A2 CUL5 CSNK2B SDC1 MED13L ARIH1 BCAP31 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide CA1 CA2 HBB CA4 SLC4A1 RHAG AQP1 HBA2 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage ASCC2 ASCC3 ALKBH3 ASCC1 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation MMUT MMAA NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression SAP30 H2AX SUDS3 DNMT3B DNMT1 SAP30L H3-3B TBP SAP18 H3C8 H2AJ H3C15 HDAC1 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 CCNH MBD2 H2AB1 POLR2E POLR2F H2AC8 POLR2H H2AC6 H2AC7 POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 SUV39H1 H2AC19 H2AC14 H2BC12L SIN3B SMARCA5 SIN3A H2BC26 H2BC21 TTF1 SAP130 UBTF SAP30BP H2BC17 POLR1A H2BC12 POLR1B H2BC13 POLR1E H2BC14 POLR1F H2BC15 POLR1G POLR1H HDAC2 BAZ2A POLR1C TAF1D TAF1B H2BC11 TAF1C POLR1D TAF1A SIRT1 RRP8 H4C9 H2AZ2 ARID4B H2AC20 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules SLC27A1 SLC35C1 SLC27A4 SLC33A1 SLC27A6 LCN9 ARL2 SLC35A3 LCN1 SLC25A5 SLC25A4 SLC29A3 SLC25A6 SLC35D2 SLC28A2 SLC29A1 SLC35A2 SLC35A1 SLC29A2 SLC28A3 SLC5A6 PDZD11 SLC35D1 SLC35B4 ARL2BP LCN15 LCN12 APOD SLC35B3 SLC35B2 SLC29A4 SLC28A1 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 CHST10 RXYLT1 FKTN SLC35A4 CRPPA FKRP B4GAT1 LARGE1 LARGE2 SLC35A1 DAG1 POMGNT1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse CD4 HLA-DRB3 TRBV12-3 HLA-DRB1 TRBV7-9 CD3G CD3E CD3D LCK TRAV19 TRAV29DV5 HLA-DQA2 PTPN22 HLA-DRB5 HLA-DRA HLA-DPA1 TRAV8-4 HLA-DRB4 HLA-DPB1 ZAP70 TRAC TRBC1 HLA-DQB2 HLA-DQB1 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway CASP8 RELA MALT1 PYCARD IL1B NFKB1 G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase CDK2 CCNA2 CCNA1 E2F1 E2F3 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding CCT6A GNAQ GNG10 GNG3 PDCL GNG2 GNG5 GNG4 GNG7 GNG8 CCT3 CCT2 CSNK2A1 CSNK2A2 CSNK2B TCP1 GNA14 GNGT1 GNA15 GNA11 GNGT2 CCT8 CCT7 GNG12 CCT5 GNG11 CCT6B CCT4 GNG13 GNB2 GNB1 RGS11 GNB4 RGS9 GNB3 RGS6 GNB5 RGS7 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair HGS NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 PGR ADAM17 NRG2 NRG3 NRG4 SPARC PSENEN PSEN2 MXD4 SRC PSEN1 APH1A NRG1 YAP1 CSN2 NCSTN APH1B STMN1 STAT5A ADAP1 TAB2 CXCL12 WWOX EREG BTC HBEGF APOE GFAP NCOR1 S100B ESR1 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 CCNB1 NUP93 NUP50 NUP35 NUP54 NUP160 CDK1 CCNB2 NUP85 NUP37 NEK9 NEK6 NEK7 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement C6 C7 C9 C5 C8B C8A C8G CLU EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells EPHA10 EFNA5 EFNA4 EFNB2 AP2A1 EFNB1 EFNB3 EPHB2 ADAM10 AP2A2 VAV3 EFNA1 EPHA1 EPHA2 EFNA3 EFNA2 RAC1 AP2M1 MMP9 VAV2 PSENEN PSEN2 CLTCL1 PSEN1 APH1A NCSTN APH1B AP2S1 CLTC DNM1 CLTA LYN AP2B1 YES1 TIAM1 EPHB6 CLTB EPHB1 FYN EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 EPHA3 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events POM121C NUP42 NUP62 NUP43 EZH2 H2BC18 TPR NUP88 RAE1 DYNC1I1 NUP214 RANBP2 NDC1 NUP210 DYNC1H1 NUP155 TRIM28 NUP153 NUP93 NUP50 NUP35 NUP54 H3C8 NUP37 NFKB1 H3C15 ELK1 SUZ12 H2BC9 H2BC8 H2BC5 H2BC3 DAXX H2BC1 NUP107 H2AC8 H2AC6 H2AC7 DYNC1LI1 DYNC1LI2 H2AC17 EGFR H2AC12 NCOR2 H2AC1 HDAC3 NUP160 H2AC19 H2AC25 H2AC14 H2AC21 NUP85 GPS2 H2BC26 H2BC21 EED TBL1X H2BC17 ITGB1 SEC13 H2BC12 H2BC13 NUP133 H2BC14 H2BC15 DYNLL1 H2BC11 CBX1 DYNLL2 NCOR1 TBL1XR1 H4C9 RBBP4 RBBP7 DYNC1I2 NUP205 POM121 H2AC20 NUP188 AAAS PML GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation SLC35D2 UGT1A3 UGT1A10 ABHD10 UGT2B10 UGT2B11 UGT2B15 UGT2B17 SLC35D1 UGT3A2 UGT3A1 UGT2A3 UGT2A2 UGT2A1 UGT1A1 UGDH UGT2B4 UGT2B7 UGT2B28 UGT1A5 UGT1A4 UGT1A9 UGT1A8 UGT1A7 UGP2 UGT1A6 UXS1 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants KIT GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle PPFIA3 PPFIA2 SLC38A2 SNAP25 ARL6IP5 SYT1 UNC13B VAMP2 CPLX1 STX1A GLS GLS2 TSPOAP1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC17A7 RAB3A SLC1A7 RIMS1 PPFIA1 PPFIA4 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 GGCX F9 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH SPRTN NPLOC4 VCP PCNA UBA52 POLH RFC5 UFD1 RFC3 RPA1 RPA2 RFC4 UBB RFC1 RFC2 UBC RPA3 RPS27A RCHY1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FCSK FPGT FUOM GFUS FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation CD3G IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK SYK IGHG3 IGHG4 IGHG1 IGHG2 FCGR3A LYN FGR YES1 FCGR1A FCGR2A PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism KYAT1 ASRGL1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PAH PCBD1 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling GAB1 RAB4B RAB4A MET HGF CRK ARF6 GGA3 CRKL LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling MTTP APOB P4HB APOF LPA CETP MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation GRSF1 FASTKD2 REXO2 SLIRP PNPT1 FASTKD5 SUPV3L1 TBRG4 LRPPRC BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins ALOX5 CYP2E1 CYP3A4 CYP2C9 EPHX2 CYP2C8 CYP2D6 CYP1A2 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation QARS1 PPA1 TARS1 AARS1 HARS1 RARS1 FARSA FARSB MARS1 YARS1 NARS1 CARS1 VARS1 RARS2 AARS2 DARS1 MARS2 WARS1 PARS2 LARS1 DARS2 SARS1 HARS2 YARS2 EEF1E1 FARS2 KARS1 WARS2 GARS1 IARS1 LARS2 SARS2 PPA2 NARS2 AIMP1 TARS2 IARS2 AIMP2 VARS2 EPRS1 CARS2 EARS2 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation SOD1 SNRPA1 MTAP CFL1 ANXA2 GSTO1 SOD2 TALDO1 LMNB1 GSTA2 IFNG CA1 MSN IL10 PSME2 HNRNPF HSPA9 TCP1 PITPNA RALA SERPINB2 PAK2 AIP MIF RPLP0 RAP1B LCP1 BOLA2B CNN2 HNRNPDL STAT4 ARF1 CDC42 PDCD4 HNRNPA2B1 PPIA CAPZA1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors PITX2 TFAP2A TFAP2C CITED2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 AURKA CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 TPX2 NINL OFD1 CPAP TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HMMR HAUS1 CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDKN1C RB1 CDKN1A CDKN1B CCND3 FZR1 CCND2 CCND1 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 CDK2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression EZH2 H2AX PRKAG1 PRKAG2 ASH2L CUL3 MAGT1 PRKAG3 TEAD1 TEAD2 JAK1 TEAD3 H3-3B TEAD4 H3C8 FOS PDCD1LG2 H2AJ B3GNT3 YAP1 DERL3 DERL1 DERL2 CTNNB1 H3C15 OS9 SPOP BRD4 SUZ12 CCND1 H2BC9 H2BC8 H2BC5 STAT1 H2BC3 STAT3 MIB2 H2BC1 FOSB CDK4 TUSC3 H2AB1 NEK2 H2AC8 H2AC6 H2AC7 MYCN TMEM258 CD274 VCP KMT2A KMT2C SEL1L TCF7 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 GSK3B DPY30 H2BC26 H2BC21 WDR5 YWHAG EP300 EED H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 CREBBP DAD1 IRF1 H2BC11 PRKAA1 PRKAA2 LEF1 RNF5 ERLEC1 PSMD8 RBBP4 RBBP5 PSMD6 PSMD7 PSMD2 NFE2L2 RBBP7 PSMD3 TCF7L2 PSMD1 H2AZ2 TCF7L1 BTRC SKP1 TNRC6C PDCD1 PSMA5 TNRC6A PSMA6 TNRC6B PSMA3 PSMA4 PSMA1 JUN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 H2AC19 H2AC14 H2BC12L MYC PRKAB2 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B ATF3 RPN2 EPAS1 RPN1 HIF1A WWTR1 H4C9 JUND ERLIN1 ERLIN2 MOV10 AGO3 AGO4 H2AC20 AGO1 AGO2 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF COL9A2 COL6A5 FURIN RASA1 PDGFRA SRC PDGFRB PDGFB CRKL NRAS STAT1 STAT3 HRAS PLCG1 PTPN12 RAPGEF1 SOS1 CRK SPP1 PDGFD THBS1 PLG PIK3CB THBS4 BCAR1 THBS3 STAT5A THBS2 STAT5B PIK3R2 PLAT PIK3CA PIK3R1 NCK2 COL4A2 NCK1 GRB7 COL4A1 COL6A2 COL4A4 COL6A1 COL4A3 COL9A1 COL6A3 STAT6 COL4A5 PTPN11 COL9A3 COL6A6 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation FGFR4 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling PPP2CA PPP2CB PPP2R1A UBA52 UBB FGF1 FGF2 UBC FGF3 FGF4 RPS27A CBL FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 MKNK1 FGF18 SPRY2 FGF10 MAPK1 MAPK3 FRS2 BRAF PTPN11 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors IAPP RAMP2 CALCA CALCR RAMP3 CALCB ADM2 CALCRL ADM RAMP1 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling ITGA2B SOS1 CRK FN1 SYK PTK2 RASGRP2 SRC AKT1 BCAR1 PDPK1 ITGB3 RAP1B SHC1 FGB FGA RAP1A VWF FGG APBB1IP RAPGEF3 CSK PTPN1 TLN1 RAPGEF4 RASGRP1 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 NEIL3 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l ALG9 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis CD3G IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 PRKACG IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK AHCYL1 ADCY9 PRKAR1B PRKAR2B PLCG2 PRKACA SYK ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 ADCY7 PRKAR2A ADCY6 ITPR1 ADCY5 ITPR2 ITPR3 IGHG3 IGHG4 PRKAR1A IGHG1 IGHG2 IL10 FCGR3A LYN FGR YES1 FCGR1A FCGR2A PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO SUMO2 UBE2I RWDD3 UBA2 SAE1 SENP5 SENP2 SENP1 SUMO1 SUMO3 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins UBE2I SUMO1 RANGAP1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events FURIN VCP CHMP2B CHMP2A GPC1 BECN1 UVRAG HSPG2 MAP1LC3B GPC3 ISCU GPC2 SDC4 SDC2 GPC5 SDC3 GPC4 GPC6 ZCRB1 NRP1 PIK3R4 AGRN TMPRSS2 SDC1 ACE2 RB1 HAVCR1 PIK3C3 VHL DDX5 CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 CTSL P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling RAC1 LINGO1 MAG OMG RTN4 VAV1 MAPK8 NGFR SQSTM1 TIAM1 SORCS3 NGF SOS1 ADAM17 RASGRF2 HDAC3 ARHGEF18 SMPD2 RHOA ARHGEF10L BAD AKAP13 ARHGEF11 ARHGEF9 ARHGEF10 ARHGEF12 ARHGEF17 BEX3 IRAK1 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 HDAC2 ECT2 PREX1 ARHGDIA MCF2L NET1 IKBKB ABR TRAF6 ITGB3BP ARHGEF16 ARHGEF40 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF19 ARHGEF5 TIAM2 OBSCN YWHAE ARHGEF4 ARHGEF26 ARHGEF7 UBA52 NGEF ARHGEF6 FGD1 FGD2 KALRN GNA13 FGD3 PRKCI FGD4 RIPK2 MYD88 BCL2L11 ARHGEF33 RELA ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 UBB AATF PSENEN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A PRDM4 APH1B NFKB1 NFKBIA HDAC1 CASP3 VAV3 CASP2 VAV2 SOS2 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling STAT5A IL15 STAT5B GAB2 GRB2 SOS1 IL2RG JAK3 SHC1 JAK1 STAT3 SOS2 IL15RA IL2RB TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes TNRC6A PRKAG1 TNRC6B PRKAG2 YWHAE RPTOR CYCS SFN PRKAG3 GLS TSC2 TSC1 COX7A2L RRAGA RRAGC PRDX2 RRAGB RRAGD PRDX1 YWHAH SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 YWHAZ YWHAB COXFA4 COX7A2 COX7A1 COX7B COX7C GPI COX8A COX8C COX5B COX5A TP53 COX6C COX4I1 COX4I2 PTEN COX6A1 AKT2 COX6A2 AKT3 AKT1 G6PD PRKAB2 COX6B2 MLST8 GPX2 PRKAB1 COX6B1 YWHAG HIGD1C RRM2B MT-CO1 TP63 TIGAR GLS2 PRKAA1 PRKAA2 SCO2 SESN3 DDIT4 YWHAQ MOV10 SESN2 MT-CO2 TXN AGO3 MT-CO3 AGO4 TXNRD1 AGO1 MTOR AGO2 TNRC6C CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL TUBGCP2 TUBGCP5 TUBGCP6 OFD1 TUBGCP3 CPAP TUBGCP4 TUBG2 MZT2B MZT2A NME7 MZT1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CDK11A CDK11B CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BCL7A PBRM1 BCL7C DPF1 BCL7B DPF2 DPF3 SMARCB1 SS18 SS18L1 ARID1A ARID1B SMARCD3 SMARCC1 SMARCC2 ARID2 BCL11A BRD7 BICRAL BICRA BRD9 SMARCD1 SMARCD2 BCL11B PHF10 SMARCA2 ACTB SMARCA4 ACTL6B ACTL6A SMARCE1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle PPFIA3 PPFIA2 LIN7A LIN7C SNAP25 LIN7B SYT1 UNC13B VAMP2 CPLX1 STX1A TSPOAP1 SLC18A2 SYN3 SYN2 SYN1 RAB3A CASK RIMS1 APBA1 PPFIA1 PPFIA4 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB2 KCNMB3 KCNMB1 KCNMB4 KCNMA1 KCNN1 KCNN3 KCNN2 KCNN4 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses SYT10 RTN3 DBNL NTRK3 SYT2 SYT1 STX1A GRIN2B SHARPIN EPB41L3 CASK GRIA1 LIN7A LIN7C LIN7B EPB41L1 HOMER3 GRIA3 EPB41 GRIA4 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 PTPRS PTPRF SIPA1L1 GRIN2C DLGAP1 DLGAP3 DLGAP2 GRIN2D DLG1 DLGAP4 GRIN1 DLG3 BEGAIN GRIN2A DLG4 DLG2 APBA3 APBA2 LRRC4B SYT7 PTPRD LRFN3 PPFIA1 LRFN2 PPFIA4 LRFN4 PPFIA3 LRFN1 GRM1 LRRTM3 PPFIA2 GRM5 LRRTM4 LRRTM1 LRRTM2 FLOT1 SYT9 IL1RAPL2 IL1RAPL1 FLOT2 SHANK3 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 SLITRK2 SLITRK1 SLITRK4 SLITRK6 PDLIM5 NLGN4Y NLGN4X SYT12 SLITRK3 SLITRK5 APBA1 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants ALK RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle RHOBTB1 TRA2B MYO6 STK38 RBBP6 RNF20 CUL3 SPEN CPSF7 TXNL1 COPS4 COPS2 PDE5A VIM CCT7 HNRNPC RBMX DBN1 SRRM1 ROCK1 CCT2 ROCK2 GPS1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis CD3G PLD4 RAC1 VAV1 PAK1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 PLD2 IGHV3-7 MAPK3 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 PRKCE IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 PIK3CB IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PIK3CA IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 HSP90AA1 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 PLD1 IGKV5-2 IGKV1-5 IGLC6 LIMK1 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 AHCYL1 BTK PLA2G6 PLCG2 MYO5A ARPC1B CFL1 ARPC1A VAV3 WASL PTK2 SYK PRKCD WAS VAV2 NF2 ITPR1 ITPR2 ITPR3 IGHG3 IGHG4 IGHG1 HSP90AB1 IGHG2 PLPP5 PLPP4 PLD3 MYH9 ACTG1 MYO9B NCKIPSD PIK3R2 ARPC4 PIK3R1 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 FCGR1A WASF3 MYO10 FCGR2A MYO1C LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy CHMP2B CHMP2A UBA52 PCNT HBB UBB UBC RPS27A IFT88 ARL13B TSG101 MVB12B MVB12A CETN1 PARK7 VPS37C RNASE1 CHMP4C HDAC6 VPS37D CHMP4B VPS37A CHMP3 VPS37B CHMP4A PLIN2 CHMP6 CFTR UBAP1 CHMP7 PLIN3 VPS28 HSPA8 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions CNTN2 NRP2 NRCAM DLG1 DLG3 DLG4 ANK1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts AKR1C3 CH25H OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 ABCB11 ACOT8 HSD17B4 SLC27A2 OSBP CYP8B1 CYP46A1 CYP39A1 NCOA1 BAAT NCOA2 ACOX2 HSD3B7 OSBPL1A SLC27A5 AKR1C1 AKR1D1 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP7A1 CYP27A1 AMACR RXRA DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels KCND2 KCND3 KCNIP1 KCNIP2 KCNIP4 KCNIP3 KCND1 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis ST3GAL2 B4GALT6 ST3GAL3 ST6GALNAC5 UGCG UGT8 B4GALT5 B3GNT5 B4GALNT1 ST6GALNAC6 B3GALNT1 FUT2 FUT1 ST8SIA5 GAL3ST1 ST3GAL5 A4GALT CERK B3GALT4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA7 CHRNA6 CHRNA9 CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis KPNA1 H1-1 SFN H1-0 H1-3 H1-2 H1-5 H1-4 CASP7 DBNL GAS2 MAPT ADD1 PLEC CDH1 CTNNB1 MAPK8 BMX BBC3 SPTAN1 PAK2 CDKN2A YWHAB E2F1 APC MAPK1 STAT3 TFDP1 MAPK3 TP73 TFDP2 BCL2 BCL2L1 GSN PRKCQ KPNB1 BID LY96 BAD CASP9 TRADD HMGB1 CASP8 YWHAG DFFB DFFA TNFSF10 HMGB2 TP63 TRAF2 DYNLL1 DYNLL2 APIP PSMD8 TLR4 PSMD6 BIRC2 PSMD7 PSMD2 YWHAQ PSMD3 XIAP PSMD1 RIPK1 FADD BAK1 PPP3R1 GSDMD TNFRSF10B GZMB TNFRSF10A NMT1 PSMA5 PSMA6 PSMA3 YWHAE PSMA4 PSMA1 FAS CYCS PSMA2 UBA52 FASLG BAX PSMD12 C1QBP PSMD11 GSDME PSMD14 PSMD13 LMNB1 PSMA7 UNC5A BCL2L11 DAPK1 TICAM2 MAGED1 PSMB6 UNC5B TICAM1 TP53BP2 PSMB7 DAPK2 PSMB4 DAPK3 YWHAH PSMB5 UBB CD14 APPL1 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 YWHAZ PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DSP TJP1 OCLN CASP3 DSG1 PKP1 SATB1 DSG2 DSG3 TJP2 PMAIP1 CLSPN PTK2 TP53 PRKCD OMA1 STK24 AVEN CASP6 DIABLO STK26 OPA1 CARD8 DNM1L UACA ACIN1 PPP1R13B AKT2 AKT3 AKT1 ROCK1 APAF1 ARHGAP10 PPP3CC BMF DCC VIM BCAP31 FNTA SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer TGFA SOS1 EREG UBA52 PIK3R1 BTC PIK3CA EPGN SHC1 HBEGF EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF UBB AREG UBC RPS27A CBL SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events PPP2CA PPP2CB PPP3CC PPP2R1B PRKAR2B PPP2R1A CALM1 PRKACA PRKACG PPP1R1B PPP2R5D PRKACB PPP1CA CDK5 PRKAR2A PDE4A PDE4D PDE4C PPP3CA PRKAR1A PPP3CB PPP3R1 PRKAR1B FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 MASP1 FCN1 FCN2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism MCCC2 PCCB ACACA MCCC1 BTD HLCS PC PCCA INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ZP1 SPAM1 ADAM21 ZP3 ADAM20 ZP2 OVGP1 ZP4 ADAM30 ADAM2 B4GALT1 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) CTNNB1 DOCK1 CBLL1 ELMO1 ARHGEF4 UBA52 CTNNA1 RAC1 VAV2 FARP2 JUP CDC42 CDH11 TIAM1 UBB CTSS SRC UBC CTNND1 CTSL CTSB RPS27A CDH1 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) ALOX5 PTGS2 CYP3A4 CYP2C9 CYP2C8 CYP2D6 CYP1A2 LTC4S CYP1A1 CYP2E1 ALOX15 GSTM4 EPHX2 ALOX12 HPGD LTA4H PTGR1 ALOX5AP LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis B3GALT5 ST3GAL3 ST6GALNAC6 B3GALT2 B3GALT1 FUT2 FUT4 FUT3 FUT6 FUT5 FUT7 FUT9 ST3GAL6 B4GALNT2 B3GALT4 ST3GAL4 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) BCL7A BCL7C DPF1 BCL7B DPF2 DPF3 SMARCB1 SS18 SS18L1 ARID1A ARID1B SMARCD3 SMARCC1 SMARCC2 BCL11A SMARCD1 SMARCD2 BCL11B PHF10 SMARCA2 ACTB SMARCA4 ACTL6B ACTL6A SMARCE1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways CHUK ITCH APP RIPK2 RELA PANX1 NFKB1 NOD1 NOD2 IRAK2 TNFAIP3 BCL2 CYLD MAPK14 BCL2L1 MAPK12 MAPK13 MAPK11 MEFV UBE2V1 CASP2 NFKB2 PYCARD HSP90AB1 CASP9 CARD9 AAMP CASP8 HMOX1 UBE2N NLRP1 TAB3 CASP4 TAB2 TAB1 IRAK1 CASP1 NLRP3 PSTPIP1 NLRC4 AIM2 IKBKB BIRC2 P2RX7 TRAF6 BIRC3 TXNIP TXN SUGT1 IKBKG MAP3K7 MAP2K6 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 TNPO1 ANAPC2 XPO1 ANKLE2 PTTG1 EMD LEMD3 RCC1 LMNB1 SPAST CC2D1B SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 TUBB6 TUBB3 TUBB1 TUBA4B PPP2R2A TUBA4A TUBA8 TUBA1C TUBA1B TUBA1A TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP188 NUP62 BANF1 NDC1 NUP155 NUP93 NUP35 NUP54 ERCC6L NUP107 ZWILCH BUB1B SMC3 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 SGO2 DYNC1LI1 DYNC1LI2 CLIP1 ZW10 MAD1L1 CDCA5 CDCA8 PDS5B PDS5A PMF1 NUP160 SKA1 KPNB1 SKA2 CCNB2 DSN1 NUP85 RAD21 RCC2 NDC80 WAPL ZWINT STAG1 LBR KIF18A STAG2 RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 SEC13 NUDC NUP133 PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 SMC1A RANGAP1 CKAP5 DYNLL2 CHMP4C KIF2A CHMP4B INCENP CHMP3 CHMP4A BIRC5 PSMD8 KIF2C CHMP6 KIF2B CHMP7 PSMD6 MAPRE1 PSMD7 ITGB3BP PSMD2 PAFAH1B1 PSMD3 DYNC1I2 PSMD1 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB NUP43 PSMA5 BUB3 PSMA6 BUB1 PSMA3 CHMP2B CLASP1 PSMA4 DYNC1I1 CHMP2A PSMA1 CLASP2 PSMA2 RANBP2 UBA52 CENPT DYNC1H1 CENPU PSMD12 RAN NDE1 PSMD11 CENPE PSMD14 CENPF PSMD13 CENPH CENPI PSMA7 TAOK1 CENPK CENPL PSMB6 CENPM PSMB7 CENPN PSMB4 B9D2 PSMB5 CENPO CENPP UBB PSMB2 CENPQ PSMB3 SPC24 MAD2L1 UBC PSMB1 CENPS RPS27A NUP37 SPC25 ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 UBE2I SUMO1 VPS4A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs MYH9 PAK1 MYLK CALM1 MYL12B PPP1CB PAK3 PPP1R12A PAK2 PPP1R12B MYH11 RAC1 FLNA NF2 LIMK1 CDC42 MYH14 MYH10 CTTN MYL6 MYL9 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle HGS RAB9B CCNE1 CUL3 PLIN3 VHL LRRC41 RHOBTB3 RAB9A PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF9 FGF20 FGF23 FGF22 PLCG1 FGF1 FGF2 FGF10 FGF3 FGF4 FGF6 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL LCLAT1 HADHB PLA2G6 HADHA TAFAZZIN PLA2G4A ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes POM121C NUP42 NUP62 FURIN TPR NUP88 RAE1 KPNA1 NUP214 SFN NDC1 NUP210 UBE2E1 NUP155 NUP153 NUP93 NUP50 JAK1 NUP35 NUP54 CDK1 EIF4E EIF4G1 STAT1 HSPA1B STAT3 MAPK3 PLCG1 KPNA7 KPNA4 KPNA5 NUP107 EIF4G3 KPNA2 HSPA8 EIF4G2 KPNA3 EIF4E3 PPP2R1B FANCC PPP2R1A IRF3 NPM1 NUP160 IFIT1 KPNB1 NUP85 FAAP100 EIF2AK2 GBP5 ISG15 PDE12 UBE2N CASP1 SEC13 NUP133 PPP2R5A RNASEL FAAP24 FAAP20 PGGT1B FLNB HSPA1L ILF2 DNAJC3 OAS2 IKBKB FANCM GBP2 FANCL GBP4 FANCA HSPA2 FANCB FANCE IKBKG FANCG FANCF UBE2L6 CHUK PPP2CA HERC5 PPP2CB NUP43 ADAR EIF2S3 OASL GBP1 EIF2S2 OAS1 EIF2S1 OAS3 RANBP2 UBA52 EIF4E2 ABCE1 BECN1 HSPA1A GBP3 SNCA MX2 MX1 CENPX UBB UBC CENPS RPS27A NUP37 EIF4A2 EIF4A1 EIF4A3 USP18 UBE2I ACTB NEDD4 SUMO1 TRIM25 PTPN2 DUS2 MAVS TP53 RIGI FLNA PIN1 PPM1B SPHK1 UBA7 ACTG1 PRKRA PIM1 TARBP2 NCK1 ILF3 DHX9 ARIH1 NUP205 POM121 NUP188 FNTA FNTB MAP2K6 AAAS CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism GATM CKMT2 SLC6A8 CKMT1B GAMT CKM SLC6A12 SLC6A11 CKB SLC6A7 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling GATA3 H2AX MMP9 H3-3B H3C8 FOS H2AJ SRC FKBP5 H3C15 NOS3 TGFA ELK1 EREG CDKN1B UHMK1 BTC EPGN CCND1 HBEGF H2BC9 H2BC8 H2BC5 NRAS H2BC3 MAPK1 HRAS H2BC1 MAPK3 FOSB EGF BCL2 AREG H2AB1 KPNA2 SMC3 H2AC8 H2AC6 H2AC7 EGFR GPAM ATF2 SP1 PRKCZ RAD21 STAG1 XPO1 H2BC26 H2BC21 STAG2 NRIP1 EP300 PDPK1 H2BC17 H2BC12 H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 PIK3CA CREBBP SMC1A H2BC11 HSP90AA1 CARM1 YY1 H2AZ2 TNRC6C TNRC6A CALM1 TNRC6B CCNT1 JUN FOXO3 MYB CBFB TBP RUNX1 GTF2A1 GTF2A2 CITED1 S1PR3 PRMT1 CDK9 HDAC1 GNGT1 KCTD6 GNGT2 ESR1 CAV1 POLR2A POLR2B GNAT3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I ESR2 POLR2J PGR POLR2K POLR2L GTF2F1 PTK2 KAT5 GTF2F2 GNAI3 AXIN1 KAT2B IGF1R ZDHHC7 GNG10 GNG3 H2AC19 ZDHHC21 GNAI1 H2AC14 PPID GNG2 H2BC12L CAV2 GNAI2 AKT2 MMP7 GNG5 MYC GNG4 AKT3 GNG7 PPP5C GNG8 AKT1 HSP90AB1 STRN SPHK1 CXCL12 MMP3 PIK3R3 PIK3R2 SRF FOXA1 PIK3R1 KDM1A TLE3 FKBP4 DDX5 POU2F1 GREB1 CHD1 CTSD GNG12 NCOA3 H4C9 GNG11 NR5A2 GNG13 TFF3 JUND TFF1 GNB2 KANK1 CXXC5 MOV10 GNB1 KDM4B AGO3 PTGES3 AGO4 GNB4 USF2 H2AC20 GNB3 USF1 AGO1 GNB5 ZNF217 AGO2 MMP2 EBAG9 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB NFKBIA IRAK1 UBA52 NGFR SQSTM1 PRKCI RIPK2 MYD88 RELA IKBKB UBB TRAF6 UBC NGF RPS27A NFKB1 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs CTNNB1 CDC42 CALM1 IQGAP1 CLIP1 MEN1 CTNNA1 IQGAP2 IQGAP3 RAC1 CDH1 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB PPP2R2D PPP2R1B PPP2R1A ARPP19 CDK1 ENSA CCNB1 MASTL ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria TFDP1 TFDP2 PMAIP1 TP53 E2F1 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants KIT TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A KDM5B CDKN1A MYC TFAP2C PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors CHRNA6 CHRND CHRNG CHRNE CHRNA1 CHRNB2 CHRNB4 CHRNA3 CHRNB3 CHRNA2 CHRNA5 CHRNA4 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants PPP2CA PPP2CB PPP2R1B PPP2R5E PPP2R1A AMER1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC AXIN1 CSNK1A1 GSK3B CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly CALM2 CASP4 CALM1 SERPINB1 CALM3 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD MMACHC MMADHC HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism HS3ST6 HS3ST4 HS6ST2 HS3ST1 HS6ST3 HS3ST2 NDST2 NDST1 NDST4 NDST3 GLCE HPSE EXTL2 GPC1 HSPG2 GPC3 HS3ST3A1 IDUA GPC2 SDC4 SGSH SDC2 HS2ST1 GPC5 SDC3 GPC4 SLC35D2 EXTL3 GPC6 AGRN HS3ST3B1 NAGLU IDS EXT1 EXT2 SDC1 HPSE2 CTSL HS6ST1 HS3ST5 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 CYCS COX7A2L PTK6 FABP1 STAT3 COXFA4 ALB ABCC1 COX7A2 COX7A1 COX7B HMOX2 COX7C RXRA COX8A COX8C PPARA COX5B COX5A COX6C NCOR2 HDAC3 COX4I1 SMARCD3 COX4I2 CHD9 COX6A1 HBB COX6A2 BACH1 SIN3A HELZ2 COX6B2 TGS1 COX6B1 HMOX1 TBL1X HIGD1C MT-CO1 NLRP3 NCOA1 MED1 NCOA2 CREBBP NCOA6 STAP2 HBA2 NCOR1 TBL1XR1 CARM1 MAFK TXNIP NFE2L2 MT-CO2 BLVRB MT-CO3 BLVRA HM13 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis CASP8 RIPK3 MLKL TRAF2 RIPK1 FADD TRADD PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling CBX6 PHC2 EZH2 PHC1 CBX4 CBX2 PHC3 RAC1 MDM2 BMI1 RING1 VAV1 SRC PIP5K1A RNF2 PIP5K1B TGFA MET RICTOR SUZ12 NTRK2 BDNF GAB1 MAPK1 NTF4 MAPK3 NTF3 CD86 EGF FRS2 CD80 AREG CD19 THEM4 NRG2 NRG3 NRG4 ATF2 HDAC3 HGF PRR5 GSK3B PIK3CD PIK3CB PIK3CG PIP5K1C MLST8 EED PDPK1 EGR1 IRAK1 PIK3CA LCK CHD4 RBBP4 CHD3 FYN TRAF6 RBBP7 RHOG PTPN11 MTOR TNRC6C INS TNRC6A SALL4 MTA2 TNRC6B REST JUN FOXO3 PIP4K2A PIP4K2B PDGFRA PDGFB KIT IL33 RAC2 HDAC1 IL1RL1 SNAI2 TP53 KDM1A SNAI1 PREX2 TRIM27 USP13 TNKS TNKS2 WWP2 RNF146 FRK OTUD3 RCOR1 RPTOR TSC2 RRAGA RRAGC USP7 RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CDKN1A EREG CDKN1B BTC EPGN HBEGF FLT3 PPP2R1B PPP2R1A EGFR KLB IRS1 IRS2 MBD3 FGF1 BAD FGF2 CASP9 FGF3 NRG1 FGF4 FGF6 FGF7 FGF9 FGF20 GATAD2B FGF23 PPP2R5E GATAD2A FGF22 GAB2 FGF16 FGF19 FGF18 PPP2R5B HDAC5 FGFR4 PPP2R5A FGF10 PPP2R5D HDAC2 PPP2R5C HDAC7 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 PML PPP2CA CHUK PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 STUB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MYD88 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PDGFRB ADRM1 TRAT1 SEM1 IRAK4 NTRK3 PIK3AP1 PSMC5 IER3 SGK1 PSMC6 PHLPP2 PSMC3 PHLPP1 PSMC4 FLT3LG PSMC1 ATN1 FOXO6 PSMC2 MAF1 FOXO4 FOXO1 RPS6KB2 MTA1 MTA3 ESR1 NEDD4 GSK3A ESR2 PPARG NR4A1 NR2E1 MECOM PTEN AKT2 AKT3 AKT1 ERBB2 STRN CSNK2A1 CSNK2A2 CSNK2B TRIB3 MAPKAP1 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INSR MOV10 AGO3 AGO4 AGO1 MKRN1 AGO2 CD28 CBX8 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation CD79B DAPP1 CD79A IGHM BLNK IGHD VAV1 SH3KBP1 IGHV3-23 IGLV NRAS IGLV2-8 IGKV1-16 IGKV1-17 HRAS IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SOS1 CD19 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 PIK3CD IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 CD22 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 PSMD8 IKBKB IGKV3D-20 PSMD6 FYN PSMD7 PSMD2 PSMD3 PPP3CA IGLV3-19 PSMD1 PPP3CB IGKV2-30 PPIA IKBKG IGHV2-70 BTRC RASGRP1 IGHV2-5 MAP3K7 RASGRP3 IGLV3-1 SKP1 PPP3R1 IGHV3-48 NFATC3 CHUK IGLV3-25 PRKCB NFATC2 IGLV3-27 PTPN6 FBXW11 NFATC1 IGKC PSMA5 IGLV3-21 FKBP1A CALM1 PSMA6 IGKV1-39 PSMA3 IGKV1-33 PSMA4 PSMA1 IGHV3-53 PSMA2 UBA52 IGLC7 CARD11 PSMD12 IGKV5-2 PSMD11 IGKV1-5 PSMD14 IGLC6 PSMD13 CUL1 BLK BCL10 PSMA7 RELA MALT1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NFKBIA PIK3AP1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REL NFKBIE NFKBIB AHCYL1 BTK PLCG2 SYK STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 PIK3R1 NCK1 LYN TRPC1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2AX TNRC6A TNRC6B RAN H3-3B H3C8 H2AJ H3C15 H2BC9 PLD6 H2BC8 H2BC5 H2BC3 H2BC1 POLR2A POLR2B POLR2C H2AB1 POLR2D POLR2E POLR2F POLR2G H2AC8 POLR2H H2AC6 POLR2I H2AC7 POLR2J POLR2K POLR2L BCDIN3D XPO5 DROSHA H2AC19 H2AC14 H2BC12L DGCR8 H2BC26 H2BC21 PIWIL2 TDRKH PIWIL1 TSNAX PIWIL4 PRKRA DICER1 DDX4 HENMT1 H2BC17 TARBP2 TSN ASZ1 MAEL H2BC12 H2BC13 MOV10L1 MYBL1 H2BC14 H2BC15 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 H2BC11 HSP90AA1 IPO8 H4C9 AGO3 ELAC2 H2AZ2 AGO4 ANG H2AC20 AGO1 AGO2 TNRC6C SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBA52 PIK3R1 PIK3CA SHC1 EGFR NRAS HSP90AA1 GAB1 CDC37 HRAS PLCG1 EGF UBB UBC RPS27A CBL FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation FGF9 FGF20 FGF23 FGF22 TGFBR3 GIPC1 ANOS1 FGF10 FGF1 FGF2 FGF3 FGF4 FGF6 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response ATM PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PHF20 UBA52 CHEK2 ZNF385A PSMD12 PSMD11 COP1 PSMD14 PCBP4 PSMD13 MDM2 MDM4 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 CCNA2 PSMB3 CCNA1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CDKN1A PSMC2 CDKN1B CDKN2A CCNE2 CCNE1 CDK2 TP53 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis POU3F2 DICER1 TNRC6A TNRC6B TRPM1 HDAC1 HINT1 BCL2 MOV10 AGO3 SIN3A AGO4 BIRC7 BCL2A1 AGO1 AGO2 TNRC6C DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA ABAT ALDH5A1 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN5 CLCN4 OSTM1 UNC79 STOM CALM1 UBA52 UBB UBC RPS27A SGK1 NEDD4L RYR1 RYR2 RYR3 CLIC2 CLCN6 TRDN ASPH BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SRI SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN TRPM1 TRPM2 ASIC4 ASIC5 TRPM7 CLCA2 TRPM8 FKBP1B CLCA1 TRPM5 ASIC2 TRPM6 ASIC3 TRPM3 CLCA4 TRPM4 ASIC1 TRPC7 WWP1 MCOLN3 TRPC5 TRPC6 TRPC3 TRPA1 TRPC4 WNK1 TRPC1 TRPV2 WNK2 RAF1 TRPV3 WNK3 TRPV1 UNC80 MCOLN1 MCOLN2 TRPC4AP TRPV6 TSC22D3 TRPV4 ANO8 TRPV5 ANO9 ANO6 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 PCSK5 MBTPS1 LIPC CREB3L3 LIPG APOA2 APOA4 APOA5 MBTPS2 ANGPTL8 ANGPTL3 ANGPTL4 LPA ABCG1 CETP MTTP LCAT LPL LMF2 LMF1 APOB APOF GPIHBP1 FGF21 APOE APOA1 APOC3 APOC2 ALB P4HB ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides DEFB108C CD4 DEFB130A DEFB130B ATOX1 DEFB4B GNLY DCD RNASE6 RNASE8 RNASE7 PRTN3 BPIFA1 BPIFA2 BPIFB1 BPIFB4 BPIFB6 EPPIN CHGA PDZD11 S100A7A ITLN1 S100A9 S100A8 HTN1 HTN3 SLC11A1 PGLYRP1 RNASE3 LYZ CLU SEMG1 LCN2 PLA2G2A ART1 DEFA1B PRSS3 PRSS2 DEFA6 DEFA4 CTSG DEFA5 DEFA3 PI3 S100A7 CCR6 BPIFB2 CCR2 TLR1 DEFB103B DEFB105B DEFB129 DEFB128 TLR2 DEFB131A DEFB127 DEFB126 DEFB125 DEFB124 BPI DEFB123 DEFB1 DEFB121 DEFB107B DEFB109B DEFB104B DEFB106B PGLYRP4 DEFB119 PGLYRP3 DEFB118 PGLYRP2 DEFB117 DEFB116 DEFB115 LTF DEFB136 DEFB114 DEFB113 REG3A REG3G DEFB135 DEFB112 ATP7A CAMP DEFB134 DEFB133 LEAP2 DEFB110 DEFB132 ELANE DEFB108B DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2CA PPP2CB PPP2R1B PPP2R1A AMER1 CSNK1G2 WNT8A WNT8B AXIN1 CSNK1A1 LRP5 LRP6 GSK3B WNT1 FZD1 CTNNB1 PPP2R5E DVL1 FZD2 DVL2 FZD5 DVL3 WNT3A PPP2R5B PPP2R5A PPP2R5D PPP2R5C APC FRAT1 CAV1 FRAT2 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response GSDMD CYCS CDKN2A BAX C1QBP GSDME AVEN DIABLO CARD8 UACA CASP3 MAPK1 CASP7 APIP MAPK3 XIAP CASP9 BAK1 APAF1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis ACD LIG1 PRIM2 DSCC1 PRIM1 POLA1 POLA2 CHTF8 RFC5 CTC1 CHTF18 RFC3 STN1 RFC4 TERF1 TEN1 RFC1 TERF2 RFC2 POT1 TERF2IP FEN1 DNA2 BLM PCNA POLD3 POLD4 WRN POLD1 POLD2 TINF2 RPA1 RPA2 RPA3 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection PPIH PPIG PPIB SFN TMPRSS2 ACE2 RB1 VHL YWHAB RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 TKFC BCL2L1 RCAN3 CTSL RPS11 KPNA2 EEF1A1 RPS10 RPS13 TBK1 RPS12 RPS9 IRF3 VCP RPS7 RPS8 RPS5 RPS6 RPSA NPM1 NPIPB3 SP1 KPNB1 RPS4Y2 RPS4Y1 PIK3R4 PALS1 GSK3B NMI RPS26 TOMM70 RPS25 RPS28 RPS27 RPS29 YWHAG EP300 RPS20 PDPK1 RPS21 CASP1 RPS24 RPS23 PIK3C3 RIPK3 RPS4X CHMP4C CHMP4B RPS3A CHMP3 CHMP4A CHMP6 CANX CHMP7 TRAF6 YWHAQ RPS27L PPIA RPS15A RPS3 RPS2 FKBP1A ITCH CHMP2B CHMP2A YWHAE UBA52 FAU BECN1 UVRAG MAP1LC3B RELA RUNX1 YWHAH TRAF3 UBB IKBKE UBC RPS27A NFKB1 NFKBIA YWHAZ PSMC6 IRAK2 UBE2I ST6GALNAC2 PRKCSH CAV1 SMAD4 SMAD3 GANAB SUMO1 ST3GAL4 GSK3A MGAT1 IFIH1 PARP6 PARP4 TRIM25 ST3GAL1 GALNT1 ST3GAL2 PARP16 ST3GAL3 PARP9 ST6GAL1 PARP14 PARP8 MOGS PARP10 SIKE1 MAVS RIGI ST6GALNAC3 ST6GALNAC4 ZCRB1 PYCARD TLR7 HNRNPA1 NLRP3 PCBP2 DDX5 BST2 SFTPD STING1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAG YWHAZ PDPK1 YWHAE AKT2 YWHAH CAV1 YWHAQ AKT3 SFN AKT1 YWHAB DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h ALG8 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA SNU13 SNW1 SNRPD2 SNRPD1 SNRPD3 TCERG1 SNRPG SNRPC SRSF8 SNRPA HTATSF1 SNRPE RBM25 PPP1R10 SNRPF SNRNP70 PRPF40A TUT1 SNRPB PPP1R8 SRSF10 SRSF12 MTREX RBM39 PPIL2 NCBP1 NCBP2 FIP1L1 PPP1CB PPP1CA XRN2 PQBP1 SRRT LSM5 LSM4 LSM3 ZCRB1 SNRNP200 LSM2 LSM7 FUS LSM6 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA3 TRA2B GPKOW CDC5L RBBP6 CCAR1 PCBP1 CPSF7 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC DHX16 RBMX NUP205 HNRNPA2B1 POM121 NUP188 WBP11 AAAS POM121C PPIE NUP42 PPIH NUP62 PPIG TPR NUP88 RAE1 DDX46 NUP214 DDX42 NDC1 RBM17 NUP210 NUP155 BUD31 NUP153 NUP93 NUP50 RBM22 DDX23 NUP35 NUP54 SMNDC1 SAP18 U2SURP HNRNPR CPSF1 CSTF3 CPSF3 CSTF2 EIF4E CPSF2 CSTF2T WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK PAPOLA SYMPK HNRNPF HNRNPD STEEP1 SF3B4 GPATCH1 SF3B5 PNN SF3B2 SF1 SF3B3 DHX8 SF3B6 PRKRIP1 SF3B1 CWF19L2 SF3A3 WDR70 SF3A1 DHX35 SF3A2 PRPF38A XAB2 SMU1 PHF5A NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A TXNL4A CACTIN SNRPN PRPF31 SLBP RBMX2 CHERP SNIP1 IK PRP4K NUP107 LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 PTBP1 YJU2 PLRG1 LSM8 SNRPA1 PPWD1 DNAJC8 USP39 SART1 PUF60 TFIP11 SNRPB2 SYF2 C9orf78 LUC7L3 PPIL1 NSRP1 SNRNP40 WBP4 RNF113A MFAP1 RBM42 BUD13 PPIL3 PPIL4 FAM50A NUP160 SRRM2 AQR NUP85 CPSF4 CRNKL1 PDCD7 SNRNP35 PRPF19 SNRNP25 RNPC3 ZMAT5 ZRSR2 SNRNP48 HNRNPH1 HNRNPH2 SEC13 NUP133 CWC25 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 PABPN1 PAPOLG NUP43 RBM7 RANBP2 UBA52 METTL14 UBB METTL3 UBC WTAP RPS27A NUP37 HNRNPU NXT1 EIF4A3 CASC3 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 THOC7 CDC40 POLR2A THOC6 POLR2B SRRM1 POLR2C DDX39A POLR2D DDX39B POLR2E SARNP POLR2F ZC3H11A POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 GTF2F1 RBM8A GTF2F2 POLDIP3 SRSF1 YBX1 U2AF1 U2AF1L4 NXF1 U2AF2 DHX38 SRSF11 ACIN1 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 DDX41 ZNF830 DHX9 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation PIK3R3 PIK3CD PIK3R2 PIK3CA PIK3R1 PIK3CB ICOSLG PIK3R6 PIK3CG PIK3R5 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 FGF9 FGF20 FGF23 FGF22 FGFR2 FGF16 FGF18 FGF10 FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib HSP90AA1 CDC37 ERBIN ERBB2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex PYGO1 PYGO2 ASH2L BCL9L TCF7 BCL9 UBA52 CHD8 MEN1 CBY1 SOX9 AKT2 SOX2 UBB SRY DPY30 UBC AKT1 XPO1 RPS27A SOX17 CTBP1 WDR5 CTNNB1 YWHAZ KMT2B HDAC1 TLE3 TLE4 APC TLE2 LEF1 RBBP5 SOX3 XIAP SOX6 TCF7L2 SOX7 TLE1 SOX4 TCF7L1 BTRC CTNNBIP1 SOX13 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 NELFB CDK7 ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE NCBP1 NCBP2 CTDP1 SUPT4H1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing POM121C NUP42 NUP62 TPR NUP88 RAE1 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 CPSF1 CSTF2 TRMT61B CLP1 NUP107 TRMT112 NUP160 TRNT1 NUP85 CPSF4 RPP30 RPP38 RPP21 SEC13 RPP25 NUP133 RPP40 ELAC2 RPP14 NUP43 TP53RK RANBP2 RAN OSGEPL1 GTPBP3 TRMU YRDC MTO1 NUP37 POP5 POP7 TSEN15 POP1 QNG1 POP4 URM1 RTCB WDR4 THADA ZBTB8OS TSEN2 LAGE3 TSEN54 OSGEP THG1L TSEN34 ALKBH8 DDX1 C2orf49 TYW1 LCMT2 RTRAF TRMT44 XPOT TRDMT1 FAM98B PUS3 TRMT10A TYW5 METTL1 EPRS1 NSUN2 TYW3 TYW2 TPRKB ADAT1 TRMT1 CDKAL1 NSUN6 PUS7 FTSJ1 ADAT3 TRIT1 ADAT2 TRMT9B QTRT1 GON7 DUS2 CTU2 QTRT2 CTU1 TRMT5 TRMT6 TRMT13 TRMT11 TRMT61A TRMT10C PRORP HSD17B10 NUP205 POM121 NUP188 AAAS BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence CBX6 PHC2 EZH2 H2AX PHC1 TNRC6A CBX4 TNRC6B CBX2 JUN PHC3 UBA52 MDM2 MDM4 BMI1 H3-3B KDM6B H3C8 RING1 FOS MINK1 UBB H2AJ UBC RPS27A RNF2 MAPK9 MAPK8 H3C15 MAP4K4 CDKN2D CDKN2B CDKN2C CDKN2A IFNB1 SUZ12 MAPK10 H2BC9 E2F1 H2BC8 E2F2 H2BC5 E2F3 H2BC3 MAPK1 H2BC1 CDK6 TFDP1 MAPK3 TFDP2 CDK4 H2AB1 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 MAPKAPK3 MAPKAPK2 TP53 H2AC19 H2AC14 H2BC12L H2BC26 H2BC21 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 MAP3K5 MAP2K3 MAP2K4 H4C9 RBBP4 MAPKAPK5 TNIK RBBP7 MOV10 TXN AGO3 H2AZ2 AGO4 H2AC20 MAP2K7 AGO1 MAP2K6 CBX8 TNRC6C REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels ATP2B4 SLC8A1 ATP2B3 ATP2B2 SLC8A2 ATP2B1 SLC8A3 CALM1 SRI ATP2A3 ATP2A2 ATP2A1 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors LTB4R LTB4R2 GPR17 CYSLTR1 CYSLTR2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC24B SEC24A BECN1 HLA-B ERAP2 HLA-A SEC24D B2M ERAP1 SEC24C HLA-H HLA-C HLA-F PIK3R4 ATG14 HLA-G HLA-E SEC31A CALR SEC13 PIK3C3 TAP2 TAP1 HSPA5 PDIA3 TAPBP CANX SEC23A SAR1B DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ LMBRD1 ABCD4 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np SHH IHH DHH HHAT PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis POMC FSHB INHBB INHBC CGA INHBE INHBA TSHB LHB CGB8 PCSK1 INHA DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling BTK PLCG2 TYROBP SOS1 VAV3 SYK RAC1 VAV2 KLRK1 B2M KLRD1 HLA-E PIK3CB PIK3R2 PIK3R1 PIK3CA TREM2 KLRC2 LCK NRAS HRAS PLCG1 FYN LCP2 GRAP2 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation FGF9 FGF20 FGF23 FGF16 FGF18 FGF1 FGF2 FGF4 FGF6 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism SLCO1B1 SLCO1B3 AKR1C3 CH25H OSBPL9 OSBPL7 OSBPL6 OSBPL3 OSBPL2 ABCB11 ACOT8 HSD17B4 SLC27A2 OSBP CYP8B1 CYP46A1 CYP39A1 NCOA1 BAAT NCOA2 STARD5 SLC10A1 ACOX2 SLC10A2 SLC51A SLC51B HSD3B7 OSBPL1A SLC27A5 AKR1C1 AKR1D1 NR1H4 AKR1C2 ABCC3 AKR1C4 ALB CYP7B1 FABP6 CYP7A1 CYP27A1 SLCO1A2 AMACR RXRA PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing FURIN H2AX TNRC6A TNRC6B TMED2 JUN MAML2 MAML1 RFNG POGLUT1 POFUT1 PRKCI MFNG H3-3B H3C8 RUNX1 H2AJ RAB6A NOTCH1 NOTCH2 H3C15 NOTCH3 NOTCH4 CCND1 H2BC9 E2F1 H2BC8 H2BC5 E2F3 H2BC3 H2BC1 TFDP1 SNW1 TFDP2 SIRT6 H2AB1 ELF3 NOTCH2NLA ATP2A3 NOTCH2NLC ATP2A2 NOTCH2NLB ATP2A1 H2AC8 ST3GAL4 H2AC6 H2AC7 ST3GAL3 LFNG SEL1L TP53 B4GALT1 KAT2B KAT2A MAMLD1 H2AC19 H2AC14 H2BC12L ST3GAL6 H2BC26 H2BC21 EP300 H2BC17 H2BC12 RBPJ H2BC13 H2BC14 H2BC15 CREBBP H2BC11 H4C9 MOV10 AGO3 H2AZ2 AGO4 H2AC20 AGO1 AGO2 ELANE TNRC6C INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade GUCY2F NMT1 CALM1 PRKCQ NMT2 PRKCA PDE6B PDE6A RHO PDE6G SAG CNGA1 RCVRN GNAT1 PPEF1 CNGB1 METAP1 METAP2 CAMKMT RGS9BP GNGT1 GNB1 GRK1 GUCA1B GUCA1A FNTA GUCY2D GUCA1C GRK7 FNTB EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle CD4 BANF1 CCR5 KPNA1 LIG1 HMGA1 LIG4 XRCC4 XRCC6 XRCC5 CXCR4 PPIA PSIP1 FEN1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA PPIA DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 CHST6 PRELP ACAN KERA OGN OMD FMOD LUM CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling CALM1 CAMK2B RASGRF2 CAMK2D RASGRF1 ACTN2 CAMK2A RPS6KA1 GRIN2D DLG1 GRIN1 DLG3 DLG4 DLG2 LRRC7 NEFL CAMK2G PDPK1 NRAS RPS6KA3 RPS6KA2 MAPK1 HRAS GRIN2B MAPK3 RPS6KA6 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis ALAS1 PRKAG1 CALM1 PRKAG2 CYCS SOD2 PRKAG3 PPARGC1B ATP5MC2 ATP5MC3 MICOS13 MICOS10 SIRT4 ATP5MC1 MT-ATP6 APOO ATP5F1A CHCHD3 SAMM50 POLRMT ATP5F1B CHCHD6 POLG2 ACSS2 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME TWNK DMAC2L HSPA9 ATP5PF ATP5PD MTX1 APOOL SSBP1 MTX2 ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D MT-ATP8 ATP5F1E TMEM11 ATP5PO IDH2 MAPK14 SIRT3 ESRRA RXRA MAPK12 MAPK11 PPARA ATF2 CRTC2 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 CAMK4 HELZ2 PRKAB2 TGS1 PRKAB1 HCFC1 TBL1X GLUD1 GLUD2 GABPA SIRT5 MEF2D PPRC1 PPARGC1A TFB1M NCOA1 PERM1 MED1 MTERF1 NCOA2 TFAM CREBBP MEF2C TFB2M NCOA6 PRKAA2 NR1D1 NCOR1 TBL1XR1 CARM1 NRF1 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade THEM4 KLB IRS1 PDE3B AKT2 PIK3R4 IRS2 FGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 GAB1 FRS2 FLT3 PTPN11 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ITGB1 PXN ILK PARVA VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis PARP1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD TBXAS1 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling DSCAM DOCK1 PRKCQ WASL NEO1 PTK2 HJV RAC1 SLIT2 EZR UNC5A ROBO1 UNC5B SRC UNC5C SIAH2 UNC5D AGAP2 SIAH1 DSCAML1 PITPNA TRIO NCK1 NTN4 TRPC7 DCC ABLIM1 TRPC5 ABLIM2 TRPC6 NTN1 ABLIM3 TRPC3 CDC42 SLIT1 SLIT3 TRPC4 TRPC1 PLCG1 MYO10 RGMB RGMA PTPN11 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN54 LIN52 LIN37 HDAC1 LIN9 E2F1 E2F4 E2F5 RBL2 RBL1 TFDP1 CDK1 RBBP4 TFDP2 CCNA2 MYBL2 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin PDS5A NIPBL RAD21 WAPL MAU2 STAG1 SMC1A STAG2 PDS5B SMC3 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A4 SLC4A10 SLC26A3 SLC12A2 SLC4A8 SLC12A3 SLC4A9 SLC12A4 SLC26A7 SLC12A5 SLC26A9 SLC12A1 SLC26A6 SLC12A6 SLC12A7 SLC13A1 SLC20A2 SLC13A4 SLC4A1 SLC26A11 SLC5A8 AHCYL2 SLC4A2 SLC26A2 SLC4A3 SLC4A7 SLC4A5 SLC34A3 SLC34A2 SLC26A1 SLC34A1 SLC20A1 SLC17A1 SLC5A5 SLC4A4 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events CXCL8 SRC SSTR3 MAPK1 C5AR1 RXFP4 RLN3 INSL5 RXFP3 OPN1SW C3 C5 PPP3CA PPP3CB PPP3R1 CALM1 CCR5 APP PRKACG PPP1R1B PRKACB CCL4L2 RGS8 PCP2 GPSM1 CDK5 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 GNGT1 OPN1MW CHRM2 PPP1CA POMC CHRM4 GNGT2 GNAT3 C3AR1 RGS9 RGS6 ADCY9 RGS7 PRKAR1B HRH4 PRKAR2B DRD3 DRD4 HTR1E HTR1F GNAI3 HTR1D ADCY4 ADCY3 HTR1B PRKX CX3CR1 ADCY2 HTR5A ADCY1 ADCY8 GNAQ GNG10 ADCY7 PRKAR2A ADCY6 GNG3 GNAI1 ADCY5 GNG2 GNAI2 GNG5 GNG4 GNG7 CAMK4 GNG8 CXCR4 GNAZ CXCL12 GNA14 GNA15 GNA11 GNG12 GNG11 GNG13 GNB2 GNB1 PF4 GNAS RGS11 PDYN GNB4 AGTR2 GNB3 FPR1 GNB5 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 OPN1LW GPR37 GPR31 RGR CCL13 CCL19 PLCB4 CCL16 P2RY12 CCL25 P2RY13 CCL21 CCL20 P2RY14 GPR55 CCL28 CCL27 CXCL13 CXCL16 ADORA3 ADORA1 MTNR1A MTNR1B PSAP CXCL10 CXCL11 ANXA1 P2RY4 CCL5 CCL4 CCL1 APLN TAS2R20 RRH OXER1 TAS2R10 PRKCG TAS2R13 TAS2R14 TAS2R16 KPNA2 GPR37L1 TAS2R19 PPP2R1B TAS2R40 PPP2R1A TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GNAL PENK PPY NBEA CCR10 CCR1 TAS2R30 TAS2R31 PPBP TAS2R38 ADRA2C TAS2R39 ADRA2B TAS2R60 ADRA2A PTGDR2 CX3CL1 CCR9 CCR8 CCR7 CCR6 CCR4 CCR3 OXGR1 CCR2 TAS2R50 CAMKK1 CAMKK2 GAL OPRD1 NPB PTGER3 CXCR5 CXCR6 CXCR1 PPP2R5D NPW CXCR3 CXCR2 GABBR2 GABBR1 NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 HCAR1 OPN3 OPN5 PYY TAS2R7 CXCL6 PPP2CA TAS2R9 PPP2CB CXCL9 TAS2R8 CXCL1 CXCL3 CXCL2 CXCL5 HEBP1 RGSL1 GRM3 GRM2 GRM4 GRM7 GRM6 GPER1 GRM8 TAS2R1 TAS2R3 TAS2R5 TAS2R4 LPAR1 RHO LPAR2 NPY5R LPAR3 SSTR1 GNAT1 FPR2 SSTR2 SSTR4 SSTR5 CORT NPY4R GPR17 OPRL1 CNR2 CNR1 TAS1R2 LPAR5 S1PR3 TAS1R1 NMS S1PR2 NMU S1PR5 TAS1R3 S1PR4 NPY ACKR3 SAA1 AHCYL1 AGT MT-RNR2 PRKACA PDE1C GNAT2 PDE1B PDE1A PMCH RGS4 GRK2 PRKCD PRKCA RGS5 PLCB3 PLA2G4A PLCB1 RGS3 PLCB2 RGS1 OPRM1 CAMK2B CASR CAMK2D CAMK2A ITPR1 ITPR2 KNG1 MCHR2 ITPR3 PRKAR1A NMUR2 NMUR1 CAMK2G OPRK1 PPP3CC MCHR1 BDKRB2 BDKRB1 RGS18 RGS17 RGS19 RGS13 RGS16 RGS21 SST SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription RB1 ZCRB1 VHL DDX5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism MTRR MTR CBLIF ABCD4 CUBN MMAA AMN CD320 MMUT LMBRD1 TCN2 MMAB MMACHC MMADHC ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling AHRR ARNT ARNT2 AIP PTGES3 HSP90AB1 AHR DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions DSCAM NTN1 DCC DSCAML1 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia ASS1 NMRAL1 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO2B1 SLCO2A1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 SLCO1A2 AVP SLCO4A1 SLCO4C1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 ITGA2B CSNK2B PAK1 ITGB1 ITGB3 ITGAV ITGA5 RAC1 EGFR VAV2 MAPK1 ITGA9 NCAM1 MAPK3 MAP2K1 NRP1 MAP2K2 L1CAM CSNK2A1 CSNK2A2 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation ITGA2B F13B F13A1 ITGB3 SERPINC1 FGB FGA SERPIND1 FGG F2 PROC SERPINE2 SERPINA5 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis SERPINA1 F5 F8 F12 KLKB1 RAC1 H3-3B F7 H3C8 F9 VAV1 PROZ H3C15 NOS3 KIF20A IFNB1 KLC1 KLC4 F10 KLC3 KLC2 DOCK3 KIF11 KIF15 PLCG1 KIF23 EGF KIF22 CLU CD74 SERPING1 KIF26A TF DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH PRKCE DGKZ DGKQ DAGLB DGKK DGKI DGKH HGF PIK3CB PIK3CG RHOB PDPK1 DOCK10 PIK3CA PLAT SERPINB8 SERPINB6 LCK JMJD1C PLAU IRF1 S100A10 HBE1 GATA5 AK3 SPN PPIL2 MICAL1 CARMIL1 CDC42 PCDH7 HBG2 HBG1 EHD1 EHD2 EHD3 FYN MAFF CSK RACGAP1 HBD AKAP10 SH2B1 CABLES2 PTPN11 PTPN6 PDPN MPIG6B FCER1G GP6 PRKACG PDE2A PRKACB GNA13 TBXA2R GNA12 SPARC ISLR HABP4 CHID1 SERPINF2 ACTN4 SLC3A2 GTPBP2 SYTL4 SLC7A11 PDE11A CD109 TAGLN2 NHLRC2 SLC7A10 PDE10A STXBP3 TEX264 STXBP2 PDGFB ENDOD1 A1BG APOH VTI1B RAB27B MANF A2M CALU MAGED2 HRG FERMT3 CEACAM6 SERPINA3 CABLES1 ORM1 ECM1 WEE1 OLA1 CEACAM8 SLC7A5 CTSW SLC7A6 ORM2 MMP1 SERPINA4 SLC7A7 EPCAM TMSB4X SLC7A8 TIMP3 SLC7A9 ALB QSOX1 AHSG ANXA5 RAPGEF3 NOS2 RAPGEF4 TOR4A GNAT3 CD63 SPP2 LEFTY2 LY6G6F VEGFB PRKAR1B VEGFC VEGFD LHFPL2 PRKAR2B PCYOX1L PLCG2 MPL F13A1 TUBA4A POTEKP CFL1 FAM3C APLP2 SYK TMX3 TP53 GNAI3 SELENOP SCG3 THPO RARRES2 HSPG2 CYRIB VPREB3 SELP VPREB1 SCCPDH CXADR ACTN2 GNAQ LGALS3BP WDR1 PSG1 SDC4 PSG3 SDC2 PLEK PHACTR2 PSG2 SDC3 GNAI1 PSG9 SRGN FCAMR GNAI2 MMRN1 PECAM1 PSG8 ITIH4 PSG5 ITIH3 PSG4 PLG PSG7 TTN PSG6 CLEC3B GYPA CDC37L1 GYPC AAMP GYPB BCAR1 CD99L2 GLG1 OLR1 CEACAM3 CD48 SDC1 SELPLG CD58 IGLL1 CD84 SIRPG SIRPA JAML PSG11 CD99 GNA14 GRB7 SELE SELL GNA15 ESAM TREM1 FGR GNA11 CD2 CD244 P2RX7 DOCK11 P2RX4 ALDOA GATA4 GATA3 PHF21A CD44 GATA2 KCNMB1 GATA1 KCNMA1 RCOR1 IGHM HMG20B GPC1 INPP5D GPC3 GPC2 DOCK6 ITPK1 DOCK9 GPC5 GPC4 GPC6 AGRN CD9 ZFPM2 PRKCG BSG TSPAN7 VPS45 SLC16A1 TGFB1 PICK1 DOCK8 PRKCB PAFAH2 MFN1 MFN2 DOCK7 RBSN PROS1 HSPA5 MERTK GAS6 ANGPT1 TEK SERPINE2 SERPINA5 THBD SMPD1 PF4V1 CD177 PROCR F11 DOK2 F13B BRPF3 CD36 TNFRSF10D PRKG2 PRKCA ANGPT4 KIFAP3 ANGPT2 GRB14 ITGAL PRKAR1A ITGA4 RAD51B RAD51C KIF3B KIF3A SERPINB2 ITGA5 MIF TRPC7 MAFG KIF3C TRPC6 TRPC3 PTPN1 ANO6 ANO5 SOD1 FN1 SRC AKAP1 SHC1 IGHV3-23 NRAS IGLV RAP1A IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 HRAS IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 P2RX6 P2RX5 V2-11 IGHV3-30 P2RX3 V3-4 P2RX2 V3-3 P2RX1 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 PRKCQ SOS1 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 RASGRP2 IGLV2-11 VEGFA IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 F11R V2-8 PRKCZ V1-20 HBB CEACAM1 IGKV2D-40 RHOA IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 APOB ITGB1 CLEC1B IGKV3-20 IGHV4-34 IGHV1-2 DOCK5 IGHV1-46 IGHV4-39 DOCK4 IGHV IGKV2-29 IGKV2-28 IGLC3 APOA1 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 LAMP2 V1-5 SLC16A8 MAFK V1-3 IGKV3D-20 V5-6 SLC16A3 IRAG1 PDE9A IGLV3-19 RHOG IGKV2-30 IGHV2-70 PPIA IGHV2-5 RASGRP1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC DOCK2 IGLV3-21 DOCK1 CALM1 IGKV1-39 IGKV1-33 V4-6 LRP8 IGHV3-53 APP V4-2 IGLC7 V4-1 IGKV5-2 SERPINE1 IGKV1-5 IGLC6 MYB PRTN3 CDK5 YWHAZ NFE2 RAC2 HDAC1 GNGT1 GNGT2 CAV1 ITGAM PROC ITGB2 IFNA5 IFNA4 IFNA7 IFNA6 MGLL IFNA1 IFNA2 IFNA8 ITGAX IFNA21 CD47 JAM2 IFNA14 JAM3 IFNA16 VAV3 IFNA17 ITGAV ABCC4 ANXA2 PTK2 IFNA10 GP9 PFN1 GP1BB VAV2 FLNA GP5 GNG10 PRKAR2A RAB5A GNG3 CYB5R1 GNG2 GNG5 CAP1 GNG4 IGF2 GNG7 IGF1 GNG8 GATA6 KDM1A ACTN1 PDE5A KCNMB2 GNG12 KCNMB3 GNG11 KCNMB4 GNG13 GNB2 GNB1 PF4 GNAS GNB4 GNB3 GNB5 ITGA2B MAG P2RY12 L1CAM GUCY1B2 KIF4B GUCY1B1 KIF4A ITGA10 F3 PSAP GUCY1A2 GUCY1A1 ABL1 CDK2 PPP2R1B PPP2R1A PPBP ADRA2C ADRA2B ADRA2A CEACAM5 SIN3A KIF18A PPP2R5E PPP2R5B PPP2R5A ADAMTS13 HDAC2 PPP2R5D PPP2R5C ITGA3 ITGA2 IRF2 ITGA1 KIF2A ITGA6 KIF2C KIF2B PLAUR PPP2CA TNFRSF10B PPP2CB TNFRSF10A CENPE ZFPM1 PTGIR GP1BA SH2B3 SH2B2 APOOL SERPINC1 STX4 CAPZB F2 CBX5 ATP2A3 CAPZA1 ATP2A2 CAPZA2 ATP2A1 SLC8A1 TIMP1 SLC8A2 TGFB2 NOS1 PRKACA F2RL2 F2RL3 ATP1B3 PDE1B ATP1B2 PDE1A ATP1B1 PRKCD STIM1 KIF5C PLA2G4A ORAI2 ORAI1 KIF5B IGHA1 KIF5A IGHA2 F2R JCHAIN ITPR1 KIF28P KIF12 ITPR2 KNG1 KIF19 ITPR3 KIF13B KIF1C THBS1 SRI KIF21A AKT1 KIF1B KIF21B TGFB3 SERPINA10 KIF1A KIF25 KIF6 KIF27 ATP2B4 ATP2B3 CFD KIF9 ATP2B2 KIFC2 ATP2B1 SLC8A3 KIF16B KIFC1 ITGB3 KIF20B ARRB1 PIK3R3 PIK3R2 ARRB2 PIK3R1 RAP1B KIF18B JAK2 PIK3R6 KIF26B PIK3R5 FGB SERPIND1 FGA LYN VWF P2RY1 FGG YES1 APBB1IP RAF1 TLN1 VCL LCP2 LAT DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 GNE CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress BAG5 HTRA2 CBX6 HSPH1 PHC2 DNAJA1 ACD EZH2 DNAJB6 DNAJA4 PHC1 BAG3 LONP1 H2AX HSF1 CBX4 BAG1 CBX2 AMER1 HSPA4 HMGA2 ST13 H1-1 PHC3 HSPA7 H1-0 HSPA6 H1-3 HSPA12A H1-2 HSPA12B H1-5 H1-4 IL6 MDM2 PREB MDM4 CXCL8 BMI1 H3-3B CABIN1 VENTX CHAC1 H3C8 KDM6B RING1 FOS TCIRG1 MINK1 GOSR2 TERF1 TERF2 H2AJ CCNA2 ATP6V1E1 CCNA1 POT1 ATP6V1E2 ATP6V0B TERF2IP CEBPB ATP6V1G1 SEC31A ATP6V0E1 RNF2 ATP6V1G2 HIRA MAPK9 H3C15 MAPK8 MAPK7 UBN1 MAP4K4 ATP6V1B2 CDKN2D ATP6V0D1 CDKN2B ATP6V0C CDKN2C ATP6V0D2 CDKN2A IFNB1 ABCG2 SUZ12 ATP6V1B1 VHL MAPK10 H2BC9 ATP6V1A H3-4 H2BC8 H2BC5 H2BC3 STAT3 ATP6V1H H2BC1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 EGF HMOX2 BCL2 PDGFA ATP6V1F AREG ATP6V1C2 BCL2L1 H2AB1 EEF1A1 H2AC8 H2AC6 H2AC7 VCP EPO CA9 HIGD1A GSK3B H2BC26 H2BC21 MLST8 NCF1 NCF2 EED NCF4 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 CYBB PRKAA2 ARFGAP1 CYBA RBBP4 RBBP7 H2AZ2 MTOR TNRC6C TNRC6A TNRC6B EIF2S3 EIF2S2 CREB3L3 EIF2S1 ELOB ELOC FBXL17 MAP1LC3B SLC7A11 PTK6 ALB P4HB IDH1 HYOU1 TP53 TALDO1 MT-CO1 NLRP3 STIP1 UFD1 DDIT3 TXNIP MT-CO2 MT-CO3 NUP205 POM121 NUP188 AAAS POM121C DNAJB11 SZT2 NUP42 SAMTOR TKT NUP62 SEH1L TPR NPRL2 NPRL3 NUP88 RAE1 GCN1 WDR59 NUP214 EIF2AK4 NDC1 FLCN NUP210 MIOS EXTL2 ITFG2 NUP155 IMPACT HMGA1 KPTN NUP153 NUP93 DEPDC5 WDR24 NUP50 SH3BP4 NUP35 FNIP1 NUP54 FNIP2 KICS2 CASTOR1 EXTL3 CASTOR2 ADD1 FKBP14 HERPUD1 MYDGF TATDN2 SERP1 CREB3L4 CREB3L1 RPL4 CREB3L2 NPLOC4 RPL5 TSPYL2 RPL30 DDX11 RPL3 WIPI1 RPL32 PDIA6 RPL31 PDIA5 RPL34 PGD ERN1 RPL10L CREB3 RPL10A DCSTAMP RPL8 CTDSP2 RPL6 KDELR3 RPL7 ATF6B DCTN1 CEBPG RPS15 CXXC1 RPS14 EXTL1 HSPA1B RPS17 SSR1 RPS16 DNAJB9 RPL18A ZBTB17 RPS19 RPS18 KLHDC3 WFS1 RPL36AL RPL36 EDEM1 BAG2 ASNS RPL35 YIF1A CREBRF RPL38 SRPRA SRPRB RPL37 SIRT3 TPP1 RPS11 HDGF RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA DNAJA2 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 RPL3L RPS26 RPS25 RPS28 RPS29 RPL27A RPS20 CALR RPS21 RPS24 RPS23 RPLP1 RPLP0 RPS4X RPL7A RPLP2 HSP90AA1 RPL13A RPS3A UBE2D3 DNAJC3 PSMD8 RPL37A EIF2AK1 PSMD6 ATF5 RPL10 PSMD7 RPL12 TXN2 PSMD2 RPL11 PSMD3 SESN2 RPL36A PSMD1 RPS27L RPS15A BTRC RPL14 RPS3 SKP1 RPL13 RPL15 RPS2 PSMA5 RPL18 PSMA6 RPL17 PSMA3 PSMA4 RPL19 PSMA1 RPL35A SULT1A3 PSMA2 RPL23A UBA52 RPL22L1 FAU PSMD12 PSMD11 RPL26L1 HSPA1A PSMD14 PSMD13 PRKCI CUL1 DCTN6 DCTN5 PSMA7 DCTN4 RELA PSMB6 CAPZA3 PSMB7 ACTR10 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA5 RORA NR3C1 ABCC1 ESR1 NR3C2 AR RXRA GSK3A PGR PPARA MRE11 LMNA BRCA1 KAT5 OMA1 NBN COX4I1 COX4I2 EIF2AK3 AQP8 NUDT2 ATF4 PRDX3 ARNT PRDX6 NOX5 UBXN7 GSTP1 NQO1 GSTA3 ERO1A SESN1 MUL1 DPP3 STAP2 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 GPX1 GPX3 RPA1 GPX6 RPA2 PALB2 GPX5 GPX8 GPX7 RAD50 ATP7A BLVRB RPA3 BLVRA HM13 CCL2 ABCF2 TXNRD2 ATM SOD3 ATOX1 ATR SOD1 CCS ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 ACTR1A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 STOML2 PHB2 YME1L1 SHC1 UBE2D2 MAPK1 MAPK3 COX7B COX7C MAPK14 COX8A MAPK11 PLA2G4B COX8C MAPKAPK3 MAPKAPK2 COX5B DCTN2 COX5A DCTN3 COX6C ATF2 VEGFA CRTC2 SLC46A1 HDAC3 CRTC3 SMARCD3 CRTC1 CHD9 LY96 COX6A1 HBB COX6A2 BACH1 NPAS2 HELZ2 G6PD RAI1 XPO1 PGRMC2 COX6B2 TGS1 COX6B1 NRIP1 HMOX1 EP300 ATF6 TBL1X APOB HIGD1C CLEC1B MEF2D PPARGC1A NCOA1 MED1 NCOA2 CREBBP MEF2C NCOA6 APOA1 HBA2 NR1D1 SIRT1 HSPA1L NCOR1 TBL1XR1 CARM1 MAFK TLR4 BMAL1 CLOCK NFE2L2 HSPA2 CAT DIS3 YWHAE PARN JUN EXOSC7 EXOSC6 EXOSC5 SOD2 EXOSC4 FOXO3 EXOSC9 KHSRP EXOSC8 EXOSC3 LMNB1 EXOSC2 PRDX2 EXOSC1 RPS6KA1 PRDX1 HSPE1 NOTCH1 RBX1 FABP1 ID1 NCOR2 GSTA1 HSP90AB1 DCP2 NOX4 CUL2 SYVN1 FKBP4 PTGES3 CUL3 RPTOR IGFBP1 RRAGA RRAGC RRAGB RRAGD AKT1S1 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 GFPT1 LAMTOR5 FKBP5 RB1 CDKN1A CDKN1B FZR1 E2F1 SQSTM1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 HIF3A CDK4 CCNE1 CDK2 ACADVL NUP107 HSPA8 MBTPS1 DYNC1LI1 DYNC1LI2 NFYA NFYB NFYC SP1 NUP160 MBTPS2 NUP85 SIN3A GPX2 RPS27 SEC13 NUP133 PPP2R5B DYNLL1 IL1A DYNLL2 HDAC6 DYNC1I2 TXNRD1 KEAP1 NUP43 DYNC1I1 RANBP2 CYCS TRIM21 DYNC1H1 COX7A2L CITED2 NUP37 HSPA9 COXFA4 CAPZB COX7A2 COX7A1 LIMD1 HIF1AN EGLN1 EGLN3 EGLN2 WTIP CAPZA1 CAPZA2 DEFA5 PRKCD CAMK2B CAMK2D PPP1R15A CAMK2A H2AC19 H2AC14 H2BC12L AKT2 MYC AKT3 HSPD1 AKT1 HSP90B1 CAMK2G CSNK2A1 CUL7 CSNK2A2 CSNK2B TRIB3 ATF3 EPAS1 HIF1A EHMT2 EHMT1 GRB10 ETS1 ETS2 RPS6KA3 RPS6KA2 MAP3K5 MAP2K3 HSPB8 HIKESHI MAP2K4 H4C9 CCAR2 TINF2 HSBP1 ERF MAPKAPK5 AJUBA DNAJC2 TNIK DNAJC7 TLN1 ASF1A MOV10 CRYAB AGO3 TXN RPS19BP1 HSPA4L AGO4 EP400 H2AC20 HSPA14 IGFBP7 AGO1 HSPA13 MAP2K7 NRF1 MAP2K6 DNAJB1 BAG4 DELE1 CBX8 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type MMUT MMAA EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection UBA1 MAGT1 VTN H3C8 CTNNB1 H3C15 RICTOR H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 SNW1 TUSC3 ELAVL1 C4BPA C4BPB CLU NEK2 H2AC8 H2AC6 EXOC1 H2AC7 TMEM258 VCP OST4 SNRPD2 SNRPD1 SNRPD3 GBF1 OSTC STT3A SNRPG STT3B SNRPE LY96 PRR5 SNRPF SNRPB XPO1 H2BC26 H2BC21 MLST8 CD209 H2BC17 C4A DDOST H2BC12 C4B_2 H2BC13 H2BC14 H2BC15 DAD1 APOA1 H2BC11 TLR4 MTOR HDLBP NMT1 H2BC18 AP2A1 COG1 AP2A2 AP2M1 BECN1 MAP1LC3B NCBP1 NCBP2 FIP1L1 AP2S1 ACOT2 AP2B1 P4HB IFIH1 TRIM25 GRPEL1 HYOU1 MAVS PQBP1 HSPG2 SDC4 TAL1 ATL2 NCL SDC2 SRRT SDC3 SNRNP200 PABPC1 FUS HSP90AB1 XRN1 NACA ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA0 HNRNPA3 SDC1 GPKOW CDC5L KDELR1 CCAR1 CD2BP2 PCBP1 CPSF7 PCBP2 RBM10 DDX5 RETREG1 SUGP1 DHX15 VIM HNRNPC DHX16 UFD1 RBMX PEX19 HNRNPA2B1 WBP11 HNRNPUL1 DNAJB11 PPIE FURIN DPM1 DPM2 RTN3 DPM3 DDX3X KPNA1 DDX46 RPTOR DDX42 RBM17 SUN2 DYNLT1 GPC1 BUD31 MMP9 GPC3 RBM22 DDX23 GPC2 RRBP1 SMNDC1 GPC5 U2SURP HNRNPR GPC4 STAT2 NRBP1 GPC6 CPSF1 CSTF3 ATG14 CPSF3 CSTF2 EIF4E CPSF2 AGRN CSTF2T BTF3 WDR33 NUDT21 HNRNPL PCF11 CLP1 HNRNPM CSTF1 HNRNPK EIF4G1 NPLOC4 PAPOLA SYMPK HNRNPF HNRNPD CLINT1 SF3B4 HAVCR1 SF3B5 SF3B2 SF3B3 SF3B6 SF3B1 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HSPA1B DAXX AUP1 IPO7 CLEC5A TXNL4A SNRPN KPNA7 BAG2 CHERP KPNA4 P4HA1 P4HA2 KPNA5 P4HA3 EIF4G3 KPNA2 HSPA8 EIF4G2 KPNA3 EIF4E3 PTBP1 SCAP PLRG1 SNRPA1 DNAJC8 PUF60 SNRPB2 SEC11A SEC11C PPIL1 SNRNP40 RPSA DNAJA2 PPIL3 PPIL4 PPIL6 SRRM2 KPNB1 AQR CPSF4 CRNKL1 PIK3R4 PRPF19 HNRNPH1 HNRNPH2 CALR SPCS3 SPCS2 SPCS1 CWC25 PDCD6IP PIK3C3 CWC27 EFTUD2 CWC22 PDIA3 PRPF6 PRPF8 HSP90AA1 CWC15 DNAJC10 ELAVL2 RBM5 DNAJC3 CANX RIPK1 PABPN1 RPL18 UBA52 HSPA1A CDC73 TAOK1 SKIC8 CTR9 RTF1 CD14 UBB IKBKE ATG7 LEO1 UBC RPS27A PAF1 NFKBIA FASN RNASEK PROS1 EIF4A2 HNRNPU CLDN1 EIF4A1 MRC1 EMC4 NFKBIB CD33 HSPA5 CD300A TIMD4 TJP1 EIF4A3 MERTK AXL TYRO3 UBE2I MAPRE3 GAS6 LY6E F2 CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D POLR2E POLR2F SUMO1 POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SRSF9 GTF2F1 GTF2F2 PRKG2 SRSF1 YBX1 U2AF1 U2AF1L4 H2AC17 H2AC12 U2AF2 DHX38 CAMK2B SRSF11 CAMK2D H2AC1 CAMK2A ALYREF H2AC19 H2AC25 H2AC14 H2AC21 RNPS1 CAMK2G UBA7 UBA6 UBA5 UBR4 MBL2 RPN2 MAPKAP1 C1QA RPN1 C1S PIK3R1 TSG101 CGAS LYN H4C9 DHX9 H2AC20 STING1 UBA3 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation GOT2 AGXT2 AMT PRODH2 GCSH GNMT KGD4 AGXT GLDC DDO HAO1 HOGA1 GRHPR DLD PXMP2 DAO OGDH DLST ALDH4A1 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border PAX7 CTNNB1 DLX5 MSX1 TFAP2A TFAP2B WNT3A POU5F1 TFAP2C MYB ZIC1 SOX2 TCF7L1 GBX2 FGF4 PAX3 BMP4 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions NRCAM CNTNAP1 NFASC ANK1 SDCBP DCX CNTN1 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy ATM MTMR14 PRKAG1 HSF1 PRKAG2 RPTOR PRKAG3 TSC2 TSC1 RRAGA RRAGC RRAGB RRAGD MTMR3 ATG14 SLC38A9 RHEB LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 WIPI1 VDAC3 VDAC2 VDAC1 UBE2D2 SQSTM1 HSPA8 TBK1 VCP UBE2V1 DYNC1LI1 DYNC1LI2 PCNT PIK3R4 TOMM70 MLST8 TOMM20 UBE2L3 TOMM22 UBE2N ARL13B PIK3C3 DYNLL1 CETN1 PRKAA1 PARK7 HSP90AA1 PRKAA2 CHMP4C DYNLL2 CHMP4B HDAC6 CHMP3 UBE2D3 CHMP4A PLIN2 CFTR CHMP6 GABARAPL3 CHMP7 ATG3 GABARAPL1 ATG9B PRKN ATG10 DYNC1I2 ATG13 ATG101 ATG16L2 ATG16L1 MTOR WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B CHMP2B ATG4A CHMP2A ATG4D TOMM40 DYNC1I1 WDR45B AMBRA1 UBA52 DYNC1H1 BECN1 UVRAG MAP1LC3B MFN1 TOMM7 MFN2 TOMM5 TOMM6 UBB OPTN ATG7 UBC RPS27A MAP1LC3A GABARAP FUNDC1 USP30 ATG9A ATG12 PEX5 ATG5 NBR1 GABARAPL2 PLIN3 ULK1 PRKAB2 IFT88 CSNK2A1 CSNK2A2 PRKAB1 CSNK2B EPAS1 MTERF3 PINK1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules LRFN1 GRIA1 FLOT1 RTN3 FLOT2 GRIA3 GRIA4 PTPRS PTPRF GRIN2C GRIN2B GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 PTPRD LRFN3 LRFN2 LRFN4 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism MMUT MMAA RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress CHUK PPP2CA CALM1 PRKACG PRKACB FLT4 RELA CAPNS1 CAPNS2 CAPN2 IKBKE PANX1 YAP1 NFKB1 NFKBIA CTNNB1 KDR NOS3 RICTOR ADM GNGT1 ABL1 STAT1 GNGT2 CDH5 ADCY9 PRKAR1B PPP2R1B PRKAR2B PPP2R1A RAMP2 PPP2R2A PIEZO1 PRKACA ITGAV CALCRL ANXA2 MMP14 PTK2 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GNAQ ADCY7 GNG10 ADCY6 GNG3 PRKAR2A ADCY5 GNG2 PRR5 PECAM1 GNG5 GNG4 PIK3CD GNG7 PRKAR1A GNG8 PIK3CB AKT1 MLST8 PDPK1 ITGB1 ITGB3 MAPKAP1 ITGA5 PIK3R2 PIK3CA P2RY2 GNA11 GNG12 GNG11 GNG13 IKBKB FYN GNB2 TLN1 PTPN1 VCL GNB1 GNAS PKN2 GNB4 IKBKG GNB3 TRPV4 GNB5 MTOR DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology WDR5 TBL1X CALM1 ASH2L PRKACA HDAC1 NCOR2 HDAC3 NCOR1 TBL1XR1 RBBP5 DPY30 SIN3A CAMK4 GPS2 KMT2D JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAPK9 UBE2N MAPK8 TAB3 TAB2 TAB1 IRAK1 UBE2V1 MAPK10 NOD1 NOD2 RIPK2 IRAK2 MAP2K4 TRAF6 IKBKG MAP2K7 MAP3K7 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines ALDH1L1 MTHFD1 ALDH1L2 MTHFD2 MTHFD2L SHMT1 FOLR2 SHMT2 SLC19A1 MTHFR MTHFS DHFR SLC46A1 SLC25A32 DHFR2 MTHFD1L DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling UBE2D1 RAC1 LINGO1 USP2 MAG OMG RTN4 VAV1 MAPK8 RACK1 UBE2D2 NGFR CASP10 SQSTM1 MIB2 TIAM1 SORCS3 NGF TBK1 MAPKAPK2 SOS1 ADAM17 RASGRF2 HDAC3 SPPL2B SPPL2A ARHGEF18 SMPD3 SMPD2 CLIP3 RHOA TAX1BP1 NSMAF ARHGEF10L BAD OTULIN AKAP13 TRADD ARHGEF11 ARHGEF9 ARHGEF10 CFLAR UBE2L3 ARHGEF12 CASP8 ARHGEF17 TAB3 TAB2 BEX3 TAB1 TNFSF10 IRAK1 ARHGEF3 ARHGEF1 ARHGEF2 TRIO ITSN1 HDAC2 TRAF2 ECT2 PREX1 ARHGDIA UBE2D3 MCF2L NET1 IKBKB BIRC2 ABR TRAF6 ITGB3BP BIRC3 ARHGEF16 XIAP RIPK1 IKBKG FADD MAP3K7 ARHGEF40 PLEKHG2 CHUK TNFRSF10B ARHGEF15 PLEKHG5 TNFRSF10A ARHGEF19 ARHGEF5 TIAM2 OBSCN YWHAE ARHGEF4 FAS TNF ARHGEF26 ARHGEF7 UBA52 NGEF FASLG ARHGEF6 STUB1 FGD1 FGD2 KALRN GNA13 FGD3 PRKCI FGD4 RIPK2 TNFRSF1A MYD88 RBCK1 BCL2L11 ARHGEF33 RELA ARHGEF35 MAGED1 ARHGEF37 MCF2 ARHGEF39 ARHGEF38 UBB AATF IKBKE PSENEN OPTN PSEN2 PSEN1 UBC APH1A NCSTN RPS27A PRDM4 APH1B NFKB1 NFKBIA HDAC1 CASP3 RNF31 TNFAIP3 SPATA2 OTUD7B SHARPIN USP21 USP4 TRAF1 CYLD OTUD1 ULK1 VAV3 TNFRSF10D CASP2 VAV2 SOS2 BAG4 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F9 F8 F10 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA MAPKAPK2 DIS3 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 YWHAB EXOSC8 EXOSC3 EXOSC2 EXOSC1 ZFP36L1 AKT1 XRN1 DCP1A DCP2 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization USP7 PTEN UBB UBA52 XIAP NEDD4 UBC RPS27A PML FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2H3 GTF2F1 GTF2F2 GTF2H4 GTF2H5 NELFB CDK7 ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE NCBP1 NCBP2 CTDP1 SUPT4H1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) HSD17B6 STRA6 HSD17B1 RDH12 RDH8 CYP4V2 LRAT RLBP1 MYO7A DHRS9 TTR RDH11 RHO ABCA4 RDH10 RPE65 RBP4 RDH16 RDH5 SDR9C7 RBP3 RBP1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm PAX8 LHX1 OSR1 FOXC2 FGF2 FOXC1 PAX2 BMP4 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes CEP57 CLASP1 YWHAE CETN2 CEP164 PLK1 DYNC1H1 NDE1 ACTR1A PCM1 CNTRL CDK1 CEP290 NINL TUBGCP2 TUBGCP5 TUBGCP6 OFD1 TUBGCP3 CPAP TUBGCP4 TUBG2 MZT2B MZT2A NME7 MZT1 TUBB HAUS4 HAUS3 HAUS6 HAUS5 TUBG1 HAUS2 HAUS1 CDK11A CDK11B CEP63 NEK2 SFI1 AKAP9 SDCCAG8 PRKAR2B PPP2R1A DCTN2 TUBA4A SSNA1 PRKACA DCTN3 HAUS8 HAUS7 PCNT CEP152 CCP110 CEP250 CSNK1E CDK5RAP2 NEDD1 CEP135 CEP131 ALMS1 CSNK1D TUBA1A CEP41 CEP43 YWHAG CEP70 CEP72 DYNLL1 CEP192 HSP90AA1 CKAP5 CEP76 CEP78 PLK4 MAPRE1 ODF2 TUBB4B PAFAH1B1 TUBB4A DYNC1I2 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome UACA MAPK1 APIP MAPK3 CYCS XIAP CASP9 AVEN DIABLO APAF1 CARD8 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway FN1 IL6 JAK1 CDK1 SRC TGFA MET SHC2 SHC3 ICMT SHC1 YWHAB NRAS RAP1A FRS3 MAPK1 GRIN2B HRAS RALGDS MAPK3 MAP2K1 MAP2K2 EGF FRS2 BRAF AREG BCL2L1 MAPK12 PRKCQ SOS1 NRG2 NRG3 RASGRP4 NRG4 HGF GFRA1 PIK3CB GDNF PDE6D PIK3CA IL2 IL3 FYN CSK RASGRP1 PTPN11 RASGRP3 CALM1 KRAS PDGFRA PDGFB RBX1 KIT PPP1CB MARK3 RET GOLGA7 PTK2 ZDHHC9 ARL2 ACTN2 GRIN2D GRIN1 DLG2 LRRC7 PPP5C NEFL FNTA CSF2 FNTB ITGA2B SPRED3 SPRED2 SPRED1 SYNGAP1 RASA3 RASA4 RASA1 RASA2 CUL3 RASAL1 RASAL2 IL2RG JAK3 RASAL3 DAB2IP NF1 KBTBD7 TYK2 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 LAMTOR2 LAMTOR3 EREG SPTAN1 BTC SPTB EPGN HBEGF NCAM1 RANBP9 FLT3 DUSP16 PPP1CC PPP2R1B PPP2R1A EGFR RASGRF2 LYPLA1 RASGRF1 KLB DLG1 IRS1 DLG3 DLG4 IRS2 FGF1 FGF2 FGF3 NRG1 ABHD17C USP17L2 FGF4 FGF6 ABHD17B FGF7 ABHD17A RCE1 FGF9 FGF20 FGF23 PPP2R5E FGF22 FGF16 FGF19 FGF18 PPP2R5B FGFR4 PPP2R5A FGF10 PPP2R5D PPP2R5C PSMD8 PSMD6 IL6R PSMD7 PSMD2 DUSP10 PSMD3 DUSP5 PSMD1 DUSP2 DUSP1 PAQR3 DUSP8 DUSP9 PPP2CA PTPN3 PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DUSP4 PDGFRB ADRM1 SEM1 DUSP6 PSMC5 DUSP7 PSMC6 PSMC3 PSMC4 FLT3LG PSMC1 PSMC2 WDR83 PTPRA RGL3 RGL1 RGL2 PEA15 IL17RD MRAS RAPGEF2 SHOC2 ARTN RASGEF1A GFRA3 GFRA2 ANGPT1 GFRA4 TEK NRTN PTPN7 PSPN PRKG2 CAMK2B CAMK2D CAMK2A ERBB2 CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 PIK3R2 IQGAP1 PIK3R1 ARRB2 RAP1B JAK2 BRAP FGB FGA KSR1 VWF FGG KSR2 APBB1IP CNKSR2 IL5RA CNKSR1 CSF2RB RAF1 CSF2RA TLN1 IL5 VCL IL2RB MAP3K11 IL3RA IL2RA KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway SOD3 TKT AMER1 CUL3 NPLOC4 PGD CDKN1A CDKN2A ABCG2 SQSTM1 SKP2 EGF BCL2 PDGFA AREG BCL2L1 VCP SP1 GSK3B BACH1 G6PD HMOX1 EP300 CREBBP PRKAA2 PSMD8 MAFK PSMD6 PSMD7 PSMD2 NFE2L2 SESN2 PSMD3 PSMD1 TXNRD1 BTRC KEAP1 SKP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 TRIM21 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PRKCI CUL1 MAP1LC3B FBXL17 PSMA7 RELA PSMB6 PSMB7 PRDX1 PSMB4 PSMB5 UBB SLC7A11 PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 NFKB1 SEM1 NOTCH1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABCC1 IDH1 BRCA1 TALDO1 PRKCD GSTA1 AKT2 MYC AKT3 AKT1 EIF2AK3 CSNK2A1 CSNK2A2 CSNK2B ATF4 UBXN7 NQO1 GSTA3 SESN1 MUL1 DPP3 GCLC MAFG GCLM SRXN1 CHD6 ME1 ABCC3 UFD1 PALB2 TXN CCL2 ABCF2 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA SLC6A1 SLC6A13 SLC6A12 SLC6A11 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD SLC35D1 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle VCP RAB7A VAMP3 MTR WDR11 UACA PAK4 TFRC RALGAPA1 DBT FAM91A1 SLC1A5 TUBA1B NSFL1C VANGL1 ROCK1 ROCK2 LAMTOR1 PAK6 PAK5 PAK1 NIPSNAP2 PAK2 SLC4A7 LCK ARHGDIG STOM RHOH JUP ARHGDIA ARHGDIB DBN1 CSK CAV1 ZAP70 TMEM59 OSBPL11 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling INHBA ACVR2A TGFBR3 INHA PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA H2AC6 H2AC7 EZH2 H2AX DNMT3B DNMT3A DNMT1 H3-3B H2AC19 H2AC14 H3C8 H2BC12L H2AJ H2BC26 H2BC21 AEBP2 H3C15 EED H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 SUZ12 EZH1 H2BC9 PHF19 H2BC8 EPOP PHF1 H2BC5 H2BC11 JARID2 H2BC3 MTF2 H2BC1 H4C9 EZHIP RBBP4 RBBP7 H2AB1 H2AZ2 H2AC20 H2AC8 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 ABCA3 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation RAB40A RAB40B RAB40C RAB7A RAB1A RAB1B RAB2A RAB6A RAB6B RAB3B RAB8A RAB9A RAB3C RAB9B RAB3D RAB44 RAB41 RAB42 RAB27B RAB2B RAB30 RAB36 RAB37 RAB8B RAB34 RAB4B RAB4A RAB33A RAB33B RAB32 RAB11B PTP4A2 RAB31 RAB38 RAB20 RAB35 RAB25 RAB26 RAB23 RAB24 RAB7B RAB21 RAB29 CHM CHML RAB15 RAB19 RAB17 RAB39A RAB27A RAB39B RAB12 RAB18 RAB5B RAB5C RAB11A RAB5A RAB3A RABGGTB RABGGTA RAB22A RAB10 RAB14 RAB13 RAB43 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells CBFB RUNX1 LGALS3 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes CDC34 UBA1 UBE2K UBE2C UBE2Z UBA52 UBE2E1 UBE2D1 UBE2Q2 UBE2E3 UBE2S USP7 UBE2R2 UBB UBC OTULIN RPS27A USP9X UBE2L3 UBA6 UCHL3 USP5 UBE2D2 UBE2H UBE2G1 UBE2B UBE2A UBE2G2 UBE2T UBE2W WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 AP2A1 FZD5 AP2S1 AP2A2 ROR1 ROR2 CLTC CLTA AP2M1 AP2B1 CLTB WNT5A ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 VWF ADAMTS13 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport OXA1L COX7B COX7C COX8A COX8C COX5B COX5A COX6C HIGD1A COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C COX19 UQCRB COX17 UQCC3 UQCC2 UQCC1 UQCC6 UQCR11 UQCC5 UQCR10 HSCB BCS1L TTC19 UQCRHL UQCRH LYRM4 CMC1 UQCRQ PYURF LYRM7 SCO1 UQCRC1 TMEM126A UQCRFS1 UQCRC2 CYC1 GOT1 TMEM126B MT-CYB TRAP1 FXN SURF1 NDUFS3 GOT2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 COX15 NDUFAF5 TIMM21 SLC25A18 NDUFAF2 NDUFB8 MDH1 SFXN4 MDH2 NDUFAF3 SLC25A12 MT-ND6 CYCS NDUFAF1 SLC25A11 HCCS SLC25A22 MT-ND4 TMEM186 SLC25A13 MT-ND5 MT-ND2 RAB5IF MT-ND3 ACAD9 MT-ND1 COQ10B COX7A2L COQ10A TMEM177 NDUFA5 DMAC1 DMAC2 PET117 ECSIT TIMMDC1 PET100 LETM1 NUBPL LYRM2 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 SDHC HSPA9 SDHD SDHA SDHB NDUFB10 COX16 NDUFB11 COX18 COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 COXFA4 HIGD2A COX20 COX7A2 ETFA COX7A1 TMEM223 COA5 NDUFC2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS2 NDUFS1 SMIM20 NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA3 NDUFA2 NDUFA1 COX4I1 COX4I2 ETFB MT-CO1 NDUFAB1 SCO2 MT-CO2 MT-CO3 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 MAML2 MAML1 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 FLT4 PSMA7 ACTA2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSENEN PSMB2 PSEN2 PSMB3 PSEN1 UBC APH1A PSMB1 NCSTN RPS27A APH1B ADRM1 HES5 SEM1 NOTCH1 YWHAZ RBX1 NOTCH2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NOTCH4 HEY1 HEY2 SNW1 SMAD3 JAG1 ADAM10 DLL4 KAT2B KAT2A MAMLD1 AKT1 HES1 EP300 RBPJ CREBBP PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TACC3 PSMD1 SKP1 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host HBB HBA2 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds CYP2C19 CYP3A4 CYP2C18 CYP3A5 CYP3A7 CYP2A7 CYP2C9 CYP2A6 CYP2W1 CYP2C8 CYP2B6 CYP2A13 CYP2D6 CYP2S1 CYP1A2 CYP1A1 AHRR CYP2E1 CYP2F1 CYP24A1 PTGS1 CYP19A1 BPHL CBR3 AADAC AOC3 AOC2 CMBL CYP51A1 MTARC2 MTARC1 CYB5B NQO2 ALDH3A1 EPHX1 FMO2 FMO3 ALDH1A1 CYP11A1 NCOA1 CYP4V2 NCOA2 CYP2R1 NR1H4 CYP7B1 CYP7A1 CYP27A1 FMO1 AOC1 CES2 ADH4 ACSS2 CES3 ALDH2 PTGIS TBXAS1 ALDH1B1 CYP4F12 ADH1C ADH1B CYP8B1 ADH1A ADH7 ACSS1 ADH5 ADH6 ARNT2 POMC PAOX CYP4F3 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP4F8 RXRA CYP26A1 CYP26B1 FDX1 CYP26C1 FDXR FDX2 MAOA CES1 HSP90AB1 CYP11B2 ARNT CYP46A1 CYP21A2 CYP39A1 POR CYP2U1 CYP27B1 CYP4F2 CYP11B1 CYP4A11 CYP1B1 AIP MAOB PTGES3 CYB5R3 CYP2J2 CYP3A43 AHR TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EZH2 PHC1 RRM2 BRCA1 PHC3 UXT CHEK1 EPC1 BMI1 RING1 YAF2 RNF2 APAF1 L3MBTL2 MAX EED PCGF6 SUZ12 EHMT2 EHMT1 E2F1 PCGF2 RBBP8 CDC7 E2F6 TFDP1 RBBP4 RYBP TFDP2 RBBP7 MGA RAD51 CBX5 CBX3 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis FDX1 HSCB FDXR FDX2 ISCA2 ISCA1 LYRM4 SLC25A28 SLC25A37 GLRX5 FXN ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS OSBPL8 PLA2G4B OSBPL5 PLA2G2A PLA2G4F PLA2G4E OSBPL10 LPCAT4 PLA2G10 PLAAT3 PLA2R1 PLA2G1B LPCAT3 MBOAT1 PLA2G5 PLA2G4A PLA2G2F PLA2G12A PLA2G2D PLA2G2E PLA1A PLA2G4D SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis CERS1 CERS2 SAMD8 ORMDL3 SGMS1 PPM1L SGMS2 ORMDL2 CSNK1G2 SPTSSB SPTSSA ORMDL1 CYB5B VAPA DEGS1 VAPB OSBP SPHK1 MFSD2B SPNS2 PRKD3 PRKD2 PRKD1 ABCG2 KDSR FA2H DEGS2 ABCC1 SPTLC1 SPTLC2 SPTLC3 CERS3 CERS4 CERS5 CERS6 SPHK2 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development HDAC3 NCOR1 TBL1XR1 TBL1X CALM1 PRKACA HDAC1 SIN3A CAMK4 GPS2 NCOR2 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins SERPINA1 PPP6C TFG PPP6R1 H2AX PPP6R3 TMED2 CTSC TRAPPC2L MAGT1 LMAN1L F5 F8 TRAPPC6A TBC1D20 USP34 TRAPPC6B GORASP1 PREB SEC22B SEC22A SEC22C H3-3B RAB1A TMED10 H3C8 LMAN2L STX17 GOSR2 RAB1B USO1 SCFD1 B3GNT3 LMAN2 CD59 SEC31B SEC31A DERL1 ANKRD28 TRAPPC2 DERL2 TRAPPC3 SEC16B H3C15 TRAPPC1 SEC16A TRAPPC10 OS9 TRAPPC4 TRAPPC5 TRAPPC9 SEC23IP CNIH1 CNIH2 SUZ12 H2BC9 CNIH3 H2BC8 FOLR1 H2BC5 BET1 H2BC3 STAT3 H2BC1 CTSH TUSC3 H2AB1 H2AC8 H2AC6 H2AC7 EIF5 EIF5B TMEM258 RNF139 UGGT2 VCP UGGT1 MARCHF6 EDEM3 AMFR SEL1L RNF103 TRIM13 OST4 NFKB2 COPS5 OSTC STT3A STT3B RNF185 H2BC26 H2BC21 WDR5 H2BC17 DDOST H2BC12 H2BC13 H2BC14 H2BC15 DAD1 H2BC11 RNF5 RBBP5 UQCRQ RBBP7 TCF7L2 UQCRC2 MT-CYB ELOB ELOC TAF10 SARS1 GBA1 ACTB DCAF7 CCT6B TUBB6 ADRB2 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 STARD7 RGS6 RGS7 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 TUBA4B TUBA4A FBXW2 XRN2 GAPDHS FKBP9 TP53 ARL2 TBCD TBCC TBCB TBCA CCT6A GNAQ TBCE PDCL FBXL3 FBXL5 TUBA8 WRAP53 TUBA1C XRCC4 TUBA1B TUBA1A KIF13A CCT3 CCT2 BAP1 UBXN1 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 GNA15 TUBA3D TUBA3C GNA11 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP188 AAAS POM121C NUP42 NUP62 TPR NUP88 RAE1 SUDS3 NUP214 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 USP10 RPL38 RPL37 RPS11 GSN RPL39 RPS10 MANEA RPS13 RPS12 RPS9 RPL21 RPS7 SFTPC RPS8 RPL23 RPS5 RPL22 RPS6 RPSA RPL9P9 RPL24 SFTPA2 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 TGFB1 EIF2AK2 OTULIN RPL3L USP17L2 RPS26 RPS25 RPS28 RCE1 RPS29 RPL27A RARS2 RPS20 AARS2 CALR MARS2 PARS2 RPS21 RPS24 DARS2 HARS2 RPS23 YARS2 RPLP1 FARS2 WARS2 RPLP0 GARS1 LARS2 RPS4X RPL7A SARS2 PPA2 RPLP2 NARS2 TARS2 PARP1 RPL13A IARS2 RPS3A VARS2 CARS2 DNAJC3 EARS2 RPL37A CANX RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU PELO RPL26L1 ABCE1 CDC73 ALG14 RNF152 SHPRH ALG13 HLA-B PEX2 RNF40 RNF144A SKIC8 SELENOS WAC CTR9 RTF1 TMEM129 HLTF LEO1 PEX10 PEX12 PEX13 PEX14 VNN1 PAF1 VNN2 RNF181 PROS1 GAS6 LY6E MGAT3 SFTPB RAB27A MYRIP OMA1 U2AF2 OPA1 TTLL10 TPGS1 TTL TPGS2 SVBP AGTPBP1 LRRC49 NICN1 VASH2 VASH1 TTLL7 AGBL5 AGBL4 TTLL6 TTLL5 TTLL4 AGBL1 TTLL3 TTLL2 ANO8 AGBL3 TTLL1 AGBL2 TTLL13 TTLL11 TTLL12 TTLL9 TTLL8 LAMB2 FN1 LAMB1 LAMC1 HLA-A B2M RAB2A PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSME1 PSME2 FOXL2 PSMD10 PSMB11 HIC1 SP3 POMP APEH PSMB10 PSMA8 PSMF1 PSMB8 PSMB9 PSMG3 PSMG4 PSMG1 PSMG2 UBE2D2 CDC34 CDH2 TOMM20 UBE2N TAB1 CHCHD2 LDHD PARK7 CFTR CS TRAF6 ACO2 TIMM17A AXIN2 TIMM22 TIMM9 TIMM10 CSF1 QARS1 RARS1 ACAD8 ACADSB MARS1 MITF DARS1 USP30 LARS1 EEF1E1 HDAC1 PGAP1 LYPD1 KARS1 LYPD2 LYPD3 IARS1 THY1 LYPD4 HADH LYPD5 POMC LYPD8 AIMP1 RHOT1 AIMP2 B3GALNT2 FUCA1 EPRS1 LYPD6B PIGS PIGU PIGT PIGO PROC PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CHST8 IFIH1 CRPPA RNF135 TRIM25 CGA PIGC PIGB TSHB PIGA PTRH2 PIGK PIGM PIGL MAVS PIGG RIGI PIGF ARF5 PIGH ARCN1 RAB5B ETFBKMT LY6K RAB5C POFUT4 POFUT2 POFUT3 RAB5A LY6D LY6H ATXN7 SPRN ETFB FCGR3B SPACA4 MDGA2 RECK MDGA1 KDELR2 GPS1 NRN1 ART3 ART4 SNX3 NTNG1 NTNG2 BST1 GPAA1 OTUD7A MIA2 RNF20 RAB22A CD52 KIN STAMBPL1 NDUFAB1 COPS4 ENGASE OTUD5 COPS2 RXYLT1 PRND EMID1 VCPIP1 CNTN5 HNRNPC UBE2T ALPL CNTN3 CNTN4 ALPG NGLY1 MYSM1 VCPKMT MMRN2 OTUB1 OTUB2 TEX101 GOSR1 FURIN RAB40A RAB40B RAB40C TNIP1 TGFBR1 TNIP3 TGFBR2 GCSH USP17L4 USP17L5 USP17L8 RNF128 ALG10B GPLD1 LIPT2 LIPT1 CHST10 RRAGA GP2 TADA2B ASGR1 PRSS21 ASGR2 EIF4EBP1 COPZ2 COPZ1 WDR20 EIF4E METTL21A EIF4B USP17L3 USP17L1 PRSS41 EEF1AKMT2 EEF1AKMT1 RAB3B RAB3C EIF4G1 RAB3D RAB44 RAB41 RAB42 LARGE2 TECTA TECTB RAB2B USP5 USP3 RAB30 VAMP2 RAB36 STX1A RAB37 APC RAB34 FKBP8 SLC34A2 STAMBP SLC34A1 RAB4B PLET1 CPM PSCA RTN4RL2 BET1L PTP4A2 MVD METTL22 RTN4RL1 RAB20 SEC23A RAB25 RAB26 POMT2 SAR1B RAB23 SEMA5A RAB24 GALNT12 RAB29 SPON2 SEMA5B EEF2KMT FKTN SPON1 THSD7B SLC35A4 FKRP POMT1 ADAMTS4 RAB15 ADAMTSL1 RAB19 RAB17 MBTPS1 ADAMTS5 SEC24B FOLR2 C1GALT1C1 NFU1 SEC24A ADAMTS2 USP17L30 ADAMTS3 YOD1 ADAMTSL5 UMOD ADAMTSL4 LIAS ADAMTS1 OTOA ADAMTSL3 MLEC ADAMTSL2 ZRANB1 MUC12 RAET1G MUC13 RAET1L THSD7A TMED3 SEC24D MUC15 TMED7 SEC24C ADAMTS8 TMED9 LARGE1 IZUMO1R ADAMTS9 CEACAM7 ADAMTS6 NRN1L ADAMTS7 CEACAM5 SBSPON USP17L21 MUCL1 USP17L20 POMGNT1 USP17L22 MUC3A LY6G6C MUC5AC LY6G6D MUC3B USP17L15 ADAMTS20 USP17L18 B3GLCT UBE2L3 USP17L17 CFP USP17L19 LSAMP THBS2 ADAMTS12 USP17L10 THSD1 USP17L12 THSD4 USP17L11 ADAMTS10 USP17L13 ADAMTS16 COPG2 ADAMTS15 COPG1 ALG10 MUC1 ADAMTS14 COPB2 ADAMTS13 COPA MUC2 TRAF2 NTM ADAMTS19 COPB1 ADAMTS18 MAN2A2 ADAMTS17 TMEM115 MUC7 ULBP2 COPE MUC4 MUC6 USP37 GALNT3 USP47 MUC16 USP48 MUC17 USP49 C1GALT1 USP42 MUC19 BIRC2 USP44 PLAUR BIRC3 SSPOP MUC5B POMGNT2 PRKN MUC20 USP16 MUC21 USP12 ABRAXAS2 RIPK1 USP19 OPCML USP24 USP25 USP26 NEGR1 USP20 USP22 USP28 XPNPEP2 POMK MT-ND6 MT-ND4L MT-ND4 OGT MT-ND5 MT-ND2 MT-ND3 MT-ND1 MTRF1 GFM2 MRRF MTRF1L MT-ATP6 ATP5F1A ATP5F1B ATP5MG HSPA9 ATP5PF ATP5PD FFAR4 ATP5F1C MT-ATP8 FFAR1 ATP5PO WDR48 UBE2B CUL4A DDB1 F2 DTL RAD18 GRP CUL4B ASCC2 ASCC3 SFTA3 DMBT1 AGT LMCD1 NAPSA PRKACA CCDC59 ADA2 PGA3 PGA5 PGA4 ADGRF5 ASPH SFTPA1 KNG1 PCCB P2RY2 TXN IGFBP7 OGDH DLST CBX8 HTRA2 PHC2 PHC1 LONP1 CBX4 CBX2 AMER1 KDM8 STS PHC3 OGFOD1 EIF5A ARSA JMJD4 DHPS IL6 FN3KRP MDM2 JMJD7 SUMF2 MDM4 SUMF1 BMI1 JMJD6 TPST2 F7 TPST1 RING1 F9 RCCD1 EIF5A2 PROZ CCNA2 DNAJC24 ARSL CCNA1 DPH1 ARSJ DPH2 RNF2 ARSK DPH3 ARSH ARSI DPH5 ARSF DPH6 ARSG DPH7 ARSD CDKN2A ZC3H15 RWDD1 FN3K ICMT F10 DOHH RIOX1 GGCX RIOX2 DRG1 DRG2 AREG EEF1B2 EEF1G EEF1A1 CPB2 EEF1D EEF1A2 EEF1A1P5 EEF2 ADAM10 NADK2 PPA1 C3 C4A ARFGAP1 ALPI EIF2B5 EIF2B4 EIF2B3 H2BC18 EIF2S3 EIF2B2 EIF2B1 MDH2 EIF2S2 EIF2S1 COP1 BECN1 KLK3 KLK2 IDE ECH1 ACOT2 ST6GALNAC2 PRKCSH ZDHHC2 FUT8 GANAB MAN2A1 MGAT5 CISH ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 SOCS2 GH1 ST3GAL3 ST6GAL1 EDEM2 MOGS MGAT4C MGAT4A MGAT4B MAN1B1 ST6GALNAC3 ST6GALNAC4 MDC1 MT-CO1 KDELR1 UFD1 SFTPD MT-CO2 MT-CO3 GATA4 GATA3 HNRNPK NPLOC4 ACTL6A DDB2 SEC11A SEC11C BGLAP SPP1 USP9X TOMM70 SPCS3 SPCS2 SPCS1 PDIA3 UBE2D3 LTF YY1 SUCLG2 FH SMC5 SMC6 NDUFA13 DDX17 NSMCE3 NSMCE2 NSMCE1 MRTFA EID3 ZBED1 UBA2 SAE1 TOP2A FOXO4 TOP2B ZNF131 ATXN3 SENP5 SOCS3 SENP2 SAFB NDUFV3 SENP1 NSMCE4A TOP1 NDUFV1 SP100 UHRF2 IDH2 SATB1 CASP8AP2 NOP58 RWDD3 MBD1 IDH3A NDUFS1 NDUFB6 FBXO32 NDUFA2 COX4I1 PTEN SRP19 SRP14 TRAM1 SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 RABGGTB RABGGTA UBXN7 MUL1 DPP3 TRIM28 L3MBTL2 TGFA APOE SATB2 COX5B COX5A NPM1 NPPA GLUD1 TFAP2B TFAP2C ANKZF1 KLHDC10 TCF25 NEMF ZNF598 CHD3 TRIAP1 AURKA INS SNCA TARS1 AARS1 HARS1 FARSA FARSB MALSU1 TUBB8 MIEF1 MTFMT YARS1 TUBB8B NARS1 CARS1 VARS1 MTIF2 GGA2 MTIF3 WARS1 GGA1 MTRFR GGA3 MTRES1 PRELID1 RAB8B RAB4A RAB33A RAB33B RAB11B RAB35 RAB7B CHM ING2 NCOR2 KAT2B KAT2A IGF2 IGF1 ZNF350 SYVN1 PCGF2 HIPK2 KDM1B MEN1 IGFBP1 USP7 IGFBP3 USP2 ADORA2A LHB PENK SIN3A FSHB HDAC2 HDAC7 KLF4 PML SEC61A2 SEC61A1 SEC61G SEC61B KCTD6 CAPZB SMAD2 SMAD1 SMAD4 SMAD3 CBX5 SMURF2 CAPZA1 CAPZA2 TIMP1 SMAD7 INHBA ARG2 CGB8 INHA AXIN1 USP15 LTBP1 THBS1 HSPD1 UCHL5 USP8 TTF1 ARRB1 ARRB2 FGA FGG NEDD8 CAND1 CP TF DBT DLD COL7A1 DCAF13 PCSK9 APOA2 APOA4 APOA5 CD109 RAB27B CALU GPIHBP1 QSOX1 ALB AHSG P4HB SPP2 APLP2 SCG3 HSPG2 SDC2 MMRN1 PLG ST3GAL6 B4GALNT2 UCHL1 SENP8 UCHL3 B4GAT1 HCFC1 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 B3GNT7 B3GNT4 B3GNT2 GPC3 SLC17A5 GOLGB1 ALG11 PDIA6 KDELR3 DCTN1 SSR1 FUT3 WFS1 EDEM1 SRPRA SRPRB B4GALT2 B4GALT3 B4GALT1 HK1 OXSM B4GALT6 CLPX CLPP ALDH18A1 PCMT1 MSRA MSRB2 B4GALT4 MSRB3 B4GALT5 ST6GALNAC6 MSRB1 TRAF3 IKBKE ALDH2 ALDH1B1 ATXN3L MTA1 JOSD2 JOSD1 TOPORS TNFAIP3 OTUD7B USP21 USP4 CYLD GALNT1 TDG CSF2RB CSF2RA MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 GALNT11 MRPS12 GALNT14 MRPL38 GALNT13 MRPS10 GALNT16 MRPL39 GALNT15 MRPL36 GALNT18 MRPL37 GALNT17 MRPL34 GALNT10 MRPL35 GALNT9 MRPL32 GALNT8 MRPL33 B3GNT9 QTGAL MRPL41 MRPL4 B3GNT8 MRPL42 B3GNT6 MRPL3 B3GNT5 CHST4 MRPL2 MRPL40 GCNT1 MRPL1 GCNT3 MRPL9 GCNT4 GCNT7 CHCHD1 MRPS28 GALNT7 GALNT6 TSFM MRPS26 GALNT5 MRPS27 GALNT4 MRPS24 GALNT2 MRPS25 A4GNT MRPS22 GALNTL5 MRPS23 GALNTL6 MRPL49 MRPS18B MRPS18A SPG7 MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 AFG3L2 MRPL46 SMDT1 MRPS6 VDAC3 MRPS5 VDAC2 MRPL43 YME1L1 MRPL44 TUFM PMPCA MRPS18C MRPL52 VDAC1 MICU2 OXA1L MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPL18 MRPS33 MRPL19 MRPS34 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPS30 MRPL15 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 KGD4 MRPL22 MRPL30 RHOA BMP4 RAB10 RAB14 RAB13 ARFGAP3 NDUFS3 RAB7A MGAT5B SHMT2 LMAN1 STX5 YKT6 KTN1 STAR TNC GMPPB PMM1 GMPPA PMM2 MPI FBN1 ABCA3 DAG1 ISL1 GSPT2 LEP GSPT1 DPAGT1 ALG8 ALG9 ALG6 ALG2 ALG3 ALG12 ALG1 MPDU1 RFT1 PABPC1 GATA6 CUL2 USP33 ETF1 HSD17B10 ST6GALNAC1 CMAS NANP FPGT PGM3 GNPNAT1 NANS GFUS NUDT14 MMP2 ST6GAL2 SLC35C1 ALG5 RENBP DHDDS DPM1 DPM2 DPM3 ST6GALNAC5 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST8SIA4 ST8SIA5 ST3GAL5 ST8SIA6 CTSA NUS1 SLC35A1 ST8SIA1 ST8SIA2 GFPT2 ST8SIA3 SRD5A3 GFPT1 DOLK NAGK FCSK DOLPP1 ACE2 VGF DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 SQSTM1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 ARF1 COMMD8 CTSZ COMMD9 PUM2 HIF3A DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 COMMD7 HSPA8 COMMD4 COMMD5 SPSB3 CCDC8 CUL9 UBD NAE1 HEMK2 SOCS6 WDTC1 SOCS5 CCDC22 COMMD10 TULP4 DCAF16 MAT2B DCAF17 FEM1C TRMT112 DCAF10 DCAF11 FEM1A FEM1B ADRA2C NEURL2 ERCC8 ADRA2A FGF23 LRR1 CCNF PDHB KEAP1 UBE2L6 HERC2 FBXO7 FBXO9 WSB1 DLAT FBXO2 ME2 RNF123 PDK1 PDHA1 UBE2J2 SIAH2 SIAH1 FBXL8 FBXL4 FBXL7 CMA1 TRIM4 SERPINC1 LRRC41 CALB1 NAT8B GAN BACE1 MFGE8 APCS TSPAN33 KLHL2 CST3 TTR UBE2G1 KLHL3 TSPAN5 H2AZ1 UBE2G2 ODAM KLHL9 LYZ SPSB2 SNCAIP SPSB1 SORL1 KBTBD6 TSPAN15 KLHL5 TSPAN14 NAT8 SEMG1 KBTBD8 TGFBI SPSB4 ITM2B FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PCSK2 PCSK1 ERO1B FBXW12 KIF5C ANPEP FBXW8 KIF5B UBE2E3 KIF5A FBXO17 CPA3 SLC30A8 FBXO15 MME SLC30A5 ATP6AP2 LMO7 FBXO10 CES1 FBXO11 ENPEP CPB1 KLHL41 GPR119 KCTD7 PLA2G7 CRHR2 KLHL42 DPP4 UBE2V2 CLTRN ACE CUL7 CUL5 CDX2 INHBB UBA6 MBOAT4 INHBC INHBE GZMH KLHL11 CPE REN KLHL13 FBXO44 FBXO41 FBXO40 TFAM BTBD1 UBE2F UBE2H KLHL25 ZBTB16 KLHL21 KLHL22 UBE2A BTBD6 FBXO30 FBXO31 KLHL20 UBE2W UBA3 ARF3 UBA1 UBE2K UBE2M KBTBD13 UBE2Q2 UBE2R2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 RCHY1 ASB18 FBXL22 ASB15 FBXL21P ASB16 FBXL20 ASB10 VHL FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 FSTL1 CHRDL1 ASB4 ASB5 ASB2 ASB3 ASB1 CTBP1 CKAP4 DNMT3B DNMT3A DNMT1 PSENEN APH1A NCSTN APH1B IL33 MMP1 POLB GNAT3 MYO5A CTSG ARFGAP2 NLRP3 ADORA2B TRIM27 USP13 TNKS TNKS2 RNF146 OTUD3 MAN1A2 MAN1C1 MAN1A1 ECI1 RAB32 RAB31 RAB38 NSF RAB21 GRIA1 CHML RAB39A RAB39B RAB12 RAB18 TADA3 PNPLA2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 IKBKG BTRC MAP3K7 SKP1 ALAS1 FBXW11 PSMA5 FECH PSMA6 PSMA3 PAX6 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 DCTN6 CUL1 BCL10 RIPK2 DCTN5 PSMA7 DCTN4 RELA CAPZA3 PSMB6 ACTR10 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 NFKBIA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 USP14 NOD1 PIAS4 NOD2 HDAC4 PIAS3 USP18 THRB UBE2I VDR NR1H2 RORA NR3C1 TNIP2 SAA1 NR2C1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA BRCA1 CCP110 CSNK1D BLM PCNA WRN BARD1 RPA1 PALB2 ARF4 UBE2C CETN2 UBE2E1 UBE2D1 ACTR1A UBE2S CDK1 STAM RAB8A HGS CTNNB1 EXOC8 STAM2 EXOC7 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 DCTN2 DCTN3 GBF1 HDAC3 RAB11A NRIP1 EP300 APOB PPARGC1A NCOA1 NCOA2 CREBBP APOA1 NFE2L2 RAB43 COG8 COG7 COG6 COG5 COG4 COG3 CALM1 COG2 COG1 APP NAPA NAPB CDC25A NAPG GOLGA2 TGOLN2 RAB6A RAB6B RAB9A RAB9B RBX1 UCN GNGT1 GNGT2 GIP IAPP CALCA GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CD55 DDX5 GCG CTSD GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 ANK2 CUL3 ANK3 ANK1 KBTBD7 SPTBN4 SPTBN5 SPTA1 SPTBN1 SPTBN2 VCAN GLB1 ARSB CDKN1A SPTAN1 CAMKMT SPTB SKP2 DAXX CCNE2 CCNE1 NUP107 SMC3 CDC20 DYNC1LI1 DYNC1LI2 CDCA8 ACHE NUP160 NUP85 RAD21 BCHE RAB3A STAG1 STAG2 RPS27 SEC13 NUP133 DYNLL1 SMC1A RUVBL1 RANGAP1 NFRKB DYNLL2 ACTR5 INCENP RAD23A BIRC5 ACTR8 RAD23B INO80C INO80B INO80E DYNC1I2 INO80D COPS7B AURKB COPS7A XPC TFPT MCRS1 NUP43 INO80 COPS3 COPS6 DYNC1I1 COPS8 RANBP2 DYNC1H1 BDH1 OXCT1 HMGCS2 ACAT1 NUP37 PRL TWNK SSBP1 EIF4A2 EIF4A1 EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B BRCC3 CLSPN TP53BP1 BABAM1 BABAM2 UIMC1 RNF168 ABRAXAS1 DMP1 LGALS1 EVA1A RAD52 CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 H2AC17 PAPPA MXRA8 H2AC12 SPARCL1 IGFALS FDX1 PRMT3 H2AC1 SCG2 KLK1 H2AC19 H2AC25 STC2 H2AC14 H2AC21 IGFBP6 H2BC12L AMELX AMBN TMEM132A MYC FUCA2 BPIFB2 HRC MELTF HSP90B1 SERPINA10 CSNK2A1 MIA3 MSLN CSNK2A2 PRSS23 BMP15 CSNK2B MEPE RCN1 ENAM RPN2 EPAS1 AMTN FAM20C VWA1 RPN1 FAM20A MATN3 PAPPA2 ITIH2 HIF1A AFP FSTL3 APOL1 SERPIND1 GOLM1 KLK13 NUCB1 NOTUM H4C9 PRKDC TRRAP H2AC20 MCFD2 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNA2D1 CACNA1B CACNG4 CACNA1A CACNA2D3 CACNA1E CACNA2D2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives PTGS2 GPX1 ALOX15 GPX4 ALOX15B GPX2 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants ITGA2B CALM1 FN1 KRAS CAMK2B CAMK2D CAMK2A SRC CAMK2G PHB1 ITGB3 ARAF PEBP1 ARRB1 IQGAP1 ARRB2 RAP1B JAK2 YWHAB BRAP MARK3 FGB NRAS FGA RAP1A KSR1 MAPK1 VWF HRAS FGG KSR2 MAPK3 APBB1IP CNKSR2 MAP2K1 CNKSR1 MAP2K2 RAF1 CSK TLN1 VCL BRAF MAP3K11 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency NAGS UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins FURIN MAP2K4 CALM1 MAP2K1 MAP2K2 PDCD6IP MAP2K7 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins POM121C PHC2 NUP42 NUP62 TPR PHC1 CBX4 NUP88 CBX2 RAE1 NUP214 PHC3 CETN2 NDC1 NUP210 NUP155 TRIM28 NUP153 NUP93 MDM2 NUP50 NUP35 NUP54 BMI1 RING1 RNF2 HNRNPK FOXL2 HIC1 L3MBTL2 SP3 CDKN2A VHL SUZ12 DAXX NUP107 SMC3 SATB2 NPM1 CDCA8 NFKB2 NUP160 NUP85 RAD21 SIN3A EIF2AK2 STAG1 CTBP1 STAG2 NRIP1 EP300 SEC13 PPARGC1A TFAP2B NCOA1 NUP133 TFAP2C NCOA2 CREBBP HDAC2 SMC1A RANGAP1 PARK7 PARP1 INCENP HDAC7 BIRC5 CHD3 IKBKG AURKB XPC PML AURKA NUP43 HERC2 RANBP2 DNMT3B DNMT3A DNMT1 RELA IKBKE SMC5 SMC6 NUP37 DDX17 NSMCE3 NSMCE2 MITF NSMCE1 NFKBIA MRTFA EID3 ZBED1 TOP2A TOP2B ZNF131 MTA1 HDAC1 SAFB PIAS4 NSMCE4A HDAC4 PIAS3 TOP1 THRB SP100 UBE2I TOPORS UHRF2 VDR SATB1 CASP8AP2 NR1H2 RORA NOP58 NR3C1 NR2C1 MBD1 ESR1 NR3C2 PIAS1 NR5A1 NR4A2 AR CBX5 RXRA SUMO1 TP53BP1 SUMO3 SUMO2 RARA PGR RNF168 PPARG PPARA ING2 BRCA1 RAD52 TP53 NCOR2 XRCC4 ZNF350 MDC1 TDG BLM PCNA WRN PCGF2 DDX5 HIPK2 H4C9 HNRNPC RPA1 NUP205 POM121 NUP188 TRIM27 AAAS CBX8 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria CASP8 GZMB NMT1 BID SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism PSPH SRR SDS PHGDH SDSL SERINC1 PSAT1 SERINC3 SERINC2 SERINC5 SERINC4 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression MLX ACACA ACLY FASN AGPAT1 MLXIPL ACACB INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling IL20RA IL20RB IL22RA2 IL22RA1 JAK3 IL10RB IFNLR1 IFNL1 TYK2 JAK1 STAT2 IL22 IL20 IL26 IL24 STAT5A STAT5B IL19 JAK2 STAT1 STAT4 STAT3 IFNL2 IFNL3 PTPN11 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes SOD3 HMOX1 ATF4 EP300 NQO1 GSTA3 CREBBP GCLC GCLM SRXN1 CHD6 GSTA1 MAFK PRDX1 SLC7A11 BACH1 NFE2L2 TXN TXNRD1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH1 NOTCH2 NOTCH3 NOTCH4 POGLUT1 POFUT1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression EZH2 H2AX ASH2L ZNF610 SMARCB1 CCNC TRIM28 H3-3B SMARCC1 SMARCC2 H3C8 MYBBP1A H2AJ ERCC6 H3C15 ZNF708 SUZ12 H2BC9 H2BC8 H2BC5 AGPAT2 H2BC3 SMARCA2 SMARCA4 H2BC1 MPHOSPH8 MBD2 H2AB1 H2AC8 H2AC6 H2AC7 ZNF765 ZNF93 ZNF816 ZNF534 KMT2A KMT2C ADIPOQ HDAC3 SMARCD3 GSK3B DPY30 H2BC26 H2BC21 MTREX WDR5 EP300 PIWIL4 EED TBL1X H2BC17 H2BC12 PPARGC1A H2BC13 NCOA1 H2BC14 MED1 H2BC15 NCOA2 CREBBP POLR1C NCOA6 H2BC11 POLR1D SIRT1 RRP8 NCOR1 TBL1XR1 PLIN2 CHD4 RBBP4 CHD3 RBBP5 RBBP7 H2AZ2 DDX21 MTA2 PHF20 DNMT3B DNMT3A DNMT1 CDK5 TBP ANGPTL4 MED4 MED6 MED7 LPL LIPE HDAC1 DGAT2 ZNF141 ZNF382 SETD1B SETD1A UHRF1 ACTB FABP4 KDM6A ZNF136 TET3 PLIN1 LPIN1 MGLL NCOR2 KAT2B KAT2A PAXIP1 SMARCA5 GPS2 BAZ1B HCFC1 NCOA3 NR5A2 ZNF33A ZNF331 ARID4B ZNF28 PSIP1 ZNF273 SAP30 SUDS3 ZNF324 DNMT3L SPOCD1 PPARGC1B MEN1 C19orf84 ZNF264 ZNF320 SAP30L SAP18 ZNF30 ZNF317 ZNF257 MED16 RB1 MED17 MED12 MED14 SF3B1 MED13 MED10 ABL1 CXXC1 ZNF547 ACTL6A MED27 MED23 MED24 MED20 CDK8 ZNF778 GPAM SCD KAT8 PHLDA1 ACSL1 HCFC2 ZNF224 WDR82 SIN3B PEX11A MBD3 BOD1L1 SIN3A MBIP TASP1 KAT14 DR1 BOD1 CIDEC TADA2A ZZZ3 GATAD2B GATAD2A YEATS2 TADA3 ZNF519 AKAP8L SGF29 ELOVL5 PHF20L1 PLIN4 SMARCD1 KANSL1 EZH1 HDAC2 KANSL2 PHF19 SMARCD2 KANSL3 EPOP THRSP PHF1 PNPLA2 JARID2 TET2 ZNF454 TET1 MTF2 EZHIP CEBPA ZCCHC8 SMARCE1 MCRS1 RBM7 TASOR PDK4 PPHLN1 OGT ACSS3 ZNF680 KMT2D KMT2B MORC2 ZNF354A MTA1 MED30 MTA3 MED31 UBE2I ZNF669 CCNH ZNF425 CBX5 POLR2E RXRA POLR2F CBX3 POLR2H SUMO2 BCL7A POLR2K BCL7C POLR2L DPF1 CD36 GTF2H1 BCL7B DPF2 GTF2H2 DPF3 SS18 GTF2H3 SS18L1 GTF2H4 ZNF418 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 SUV39H1 ARID1A ARID1B H2AC19 H2AC14 H2BC12L ZNF649 ATF7IP SETDB1 AEBP2 TTF1 SAP130 UBTF DEK SAP30BP TDG POLR1A POLR1B POLR1E POLR1F POLR1G POLR1H BAZ2A EHMT2 TAF1D EHMT1 TAF1B PAGR1 TAF1C TAF1A H4C9 AJUBA H2AC20 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R SOS1 THEM4 IGF1R KLB IRS1 PDE3B AKT2 PIK3R4 IRS4 IRS2 IGF2 FGF1 IGF1 PIK3CB FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 TRIB3 FGF22 PDPK1 GAB2 FGF16 FLT3LG FGF19 FGF18 TLR9 PIK3R2 PIK3C3 PIK3R1 PIK3CA FGFR4 FGF10 NRAS GAB1 HRAS FRS2 FLT3 PTPN11 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs FURIN PCSK6 PCSK5 RAC1 FOS NAB1 NAB2 SH3GL3 ARC TRIB1 TPH1 SRC RRAD MAP2K5 EGR3 EGR4 FOSL1 ID2 ID3 DNAL4 MAPK7 LYL1 F3 SH3GL2 VGF ELK1 ASCL1 RALA CDK5R2 SHC2 RALB SHC3 DNM1 SHC1 DNM3 YWHAB NTRK2 CRKL DOCK3 BDNF ADORA2A NRAS RAP1A GAB1 FRS3 MAPK1 STAT3 GRIN2B HRAS RALGDS NTF4 TIAM1 MAPK3 NTF3 NTRK1 MAP2K1 PLCG1 FOSB MAP2K2 KIDINS220 FRS2 BRAF MAPK14 NGF MAPK12 MAPK13 MAPK11 RIT1 DNM2 RIT2 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 RAPGEF1 SOS1 CRK ATF2 PTPRS PTPRO IRS1 IRS2 RHOA PIK3CB RPS6KA5 EP300 ID4 EGR1 MEF2D CLTC PIK3CA PPP2R5D MEF2C CLTA CHD4 PTPN11 PPP2CA PPP2CB AP2A1 AP2A2 REST BAX AP2M1 NELFB JUNB CDK5 RPS6KA1 ATF1 CDK5R1 MEF2A DUSP4 DUSP3 NTRK3 VRK3 DUSP6 DUSP7 SGK1 AP2S1 AP2B1 ID1 ADCYAP1 ADCYAP1R1 EGR2 TCF12 PIK3R2 SRF PIK3R1 RPS6KA3 RPS6KA2 JUND NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC AKT1 PSMB1 RPS27A ADRM1 SEM1 YWHAZ RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NOTCH4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 TACC3 PSMD1 SKP1 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation RPS6KA3 RPS6KA2 MAPK1 PDPK1 RPS6KA1 MAPK3 RPS6KA6 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling PTPN6 SOS1 SYK IL2RG INPPL1 JAK3 HAVCR2 INPP5D JAK1 IL21R LGALS9 IL15RA PIK3CD IL21 PIK3CB STAT5A IL15 STAT5B GAB2 GRB2 PIK3R3 PIK3R2 PIK3R1 PIK3CA IL9 SHC1 JAK2 LCK IL9R IL2 STAT1 IL3 STAT4 STAT3 SOS2 PTK2B IL5RA CSF2RB CSF2RA IL5 IL2RB IL3RA CSF2 IL2RA LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival FURIN CD3G IL6 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 V2-11 PLCG1 IGHV3-30 V3-4 V3-3 V2-17 V3-2 MAPK14 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 ADAM17 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGLV3-21 CALM1 IGKV1-39 IGKV1-33 V4-6 IGHV3-53 V4-2 PRKACG IGLC7 V4-1 IGKV5-2 PRKACB IGKV1-5 IGLC6 HCK GNGT1 GNGT2 GNAT3 AHCYL1 ADCY9 PRKAR1B PRKAR2B PLCG2 PRKACA SYK GNAI3 ADCY4 ADCY3 PRKX ADCY2 ADCY1 ADCY8 GNG10 ADCY7 PRKAR2A ADCY6 GNG3 ITPR1 GNAI1 ADCY5 GNG2 ITPR2 GNAI2 GNG5 ITPR3 GNG4 IGHG3 GNG7 IGHG4 PRKAR1A GNG8 IGHG1 CYSLTR1 IGHG2 IL10 CYSLTR2 CD163 GGT1 PLK2 DPEP2 RHBDF2 DPEP1 MYH9 GNAZ GGT5 FCGR3A LYN FGR YES1 GNG12 ADORA2B GNG11 FCGR1A GNG13 GNB2 GNB1 FCGR2A GNAS GNB4 GNB3 GNB5 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors LIN7A LIN7C LIN7B GRIN3B GRIN3A NBEA CAMK2B CAMK2D ACTN2 CAMK2A KIF17 GRIN2C GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 NEFL CAMK2G GRIN2B CASK APBA1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 FGF9 FGF20 FGF23 FGF22 FGF16 SOS1 FGF18 PIK3R1 PIK3CA FGF10 NRAS GAB1 FRS3 HRAS PLCG1 FRS2 FGF1 FGF2 FGF3 PTPN11 FGF4 FGF6 FGF7 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein GSK3A PARP6 UBE2I PARP4 PARP16 PARP9 PARP14 PARP8 PARP10 GSK3B SUMO1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KCNJ2 KCNJ3 GNGT1 KCNJ4 GABBR2 KCNJ5 KCNJ6 GNGT2 GABBR1 KCNJ10 GNG12 GNG11 GNG13 KCNJ12 KCNJ9 GNB2 GNB1 KCNJ15 KCNJ16 GNB4 GNB3 GNB5 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation B4GALT6 ST6GAL1 MGAT4C B4GALT4 B4GALT2 MGAT4A B4GALT5 B4GALT3 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 ST8SIA3 MGAT5 ST3GAL4 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology EZH2 H2AX ASH2L RAC1 TEAD1 TEAD2 H3-3B TEAD4 H3C8 FOS SRY H2AJ ATP6V1E1 YAP1 ATP6V0B ATP6V1G1 ATP6V0E1 H3C15 PAK1 ATP6V1B2 ATP6V0D1 ATP6V0C PAK3 PAK2 SUZ12 H2BC9 ATP6V1A H2BC8 H2BC5 H2BC3 STAT3 ATP6V1H H2BC1 ATP6V1C1 NR2F2 H2AB1 H2AC8 H2AC6 H2AC7 KMT2A KMT2C TCF7 STT3B GSK3B PIK3CD DPY30 PIK3CB H2BC26 H2BC21 ARHGEF11 ARHGEF12 WDR5 YWHAG EED RHOB H2BC17 H2BC12 H2BC13 H2BC14 POU2F2 H2BC15 PIK3CA ARHGEF28 COL4A2 H2BC11 COL4A1 COL6A2 JUP LEF1 COL4A4 CDC42 COL6A1 RBBP4 COL4A3 RBBP5 FYN COL9A1 DIAPH1 RBBP7 COL6A3 TCF7L2 H2AZ2 TCF7L1 PTPN11 KRT4 COL4A5 COL9A3 KRT3 TNRC6C KRT2 COL6A6 COL9A2 KRTAP17-1 KRT8 COL6A5 KRT7 TNRC6A KRT5 AP2A1 TNRC6B KRT9 RHOC KRTAP4-11 AP2A2 KRTAP20-1 KRTAP20-2 ARHGEF7 TNF KRTAP10-10 PRKACG NGEF KRTAP10-11 KRTAP10-12 KRTAP27-1 PRKACB ELOB KRT33B KRTAP5-10 AP2M1 ELOC KRT33A KRTAP5-11 KRTAP16-1 KRTAP8-1 KRTAP26-1 KRT24 NCBP1 KRT23 NCBP2 KRT20 KRT28 PLXNB1 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 ANGPTL4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 LPL KRTAP9-2 KRTAP9-1 AP2S1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 KRTAP25-1 KRTAP2-4 AP2B1 KRTAP2-3 KRTAP2-2 KRTAP2-1 ACTB KRT13 KRT12 KRT10 KRT19 KRT18 KRT17 KRT16 KRT15 LEFTY2 KRT14 KRTAP24-1 KRTAP3-3 KRTAP3-2 KRTAP3-1 KRT6C KRT6B KRT6A KRT71 KRTAP13-2 CFL1 KRTAP13-1 KRTAP13-4 KRTAP13-3 KRT79 TP53 KRT78 KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 KRTAP23-1 GPR143 KRT40 KRTAP4-4 SDC2 KRTAP4-3 KRTAP4-2 KRTAP4-1 PAXIP1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 EYA1 KRTAP11-1 KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 CTNNA1 GRB7 KRTAP19-1 KRTAP19-4 FOXF1 KRTAP19-3 RND1 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 SNAI1 PLXNA1 KRT82 PLXND1 KRT81 KRTAP21-2 KRT80 KRTAP21-3 PBX1 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 PKP4 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 GPC1 AGRN RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPL10L RPL10A RPL8 RPL6 RPL7 RPS15 RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 DMRT1 ZFPM2 RPL35 PTGDS RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPSA FGFR1 RPL9P9 RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPS4Y1 RPL39L RPL41 TGFB1 RPL3L RPS26 RPS25 RPS28 RPS29 KLF13 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP1 CLTC RPLP0 CLTA RPS4X MESP1 RPL7A RPLP2 TBX20 SMYD1 HSP90AA1 TBX1 MYOCD RPL13A HAND1 RPS3A GDF1 RPL37A RPL10 RPL12 RPL11 RPL36A RPS27L RPS15A PABPN1 RPL14 RPS3 RPL13 RPL15 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPL22L1 FAU RPL26L1 ARHGAP39 SLIT2 SEMA4D SRGAP3 LIMK2 SRGAP2 LIMK1 FOXH1 RRAS SRGAP1 DRAP1 CBFB ROBO1 MYH14 MYH10 RUNX1 UCP1 HNRNPU MTA1 PRDM16 ZNF423 MTA3 ELOVL3 CIDEA EIF4A3 EBF2 CASC3 BMP7 MAGOH GMPR PMEL BCL7A MLANA BCL7C DPF1 BCL7B DPF2 DPF3 SS18 RBM8A SS18L1 RAB27A MYRIP PRKCA SYTL2 MLPH IRF4 UPF3B MAGOHB RNPS1 SOX2 ZEB2 FGF8 SOX1 GBX2 OTX2 TBX6 BTG4 POU3F1 ZFP36L2 ZNF521 PABPN1L DICER1 PITPNA TRPM1 TRPC7 STAT4 TRPC5 TRPC6 IL12RB2 TRPC3 TRPC4 TRPC1 IL5 LAMA5 LAMB3 LAMA2 LAMA1 LAMC3 LAMB2 LAMA4 LAMA3 FN1 LAMC2 LAMB1 LAMC1 VTN TCHH TGM1 LCE1A CASP14 LCE1B LCE5A LIPJ CDON LIPN LIPM PRSS8 LIPK TGM5 RPTN CELA2A SPINK6 SPINK5 KAZN LCE1E LCE1F LCE1C LCE1D LCE2B LCE2C LCE2A IL4 LCE6A PKP2 LORICRIN IL13 SPINK9 PKP3 DSG4 DSC1 IVL DSC2 DSC3 FLG PRKCQ SPRR2E SPRR2F SPRR3 SPRR2G CSTA KLK5 EVPL FOXC2 FOXC1 PPL KLK8 SIX1 PCDH19 LCE2D HOXD11 LCE3C HOXC11 ADIPOQ LCE3D WFDC2 LCE3A LCE3B HOXA11 GXYLT2 LELP1 PLAC8 SALL1 CDH2 PI3 SPRR2A PXN SIX2 HOXA6 TERT SPRR2B EDIL3 IRX1 SPRR2D ST14 IRX2 CEACAM1 EMX2 ZEB1 CDSN RHOA PXDN KLK14 OSR1 BIRC7 LCE3E GFRA1 KLK12 NPNT ASAH1 POU3F3 BCL2A1 LCE4A TBX2 PAX2 SPRR1A BMP4 SPRR1B GREM1 RPS6KA5 GDNF PAX8 LHX1 ID4 ITGB1 HOXB4 DIS3L2 TRIO ITSN1 SLC2A4 ARHGAP35 LEFTY1 ACVR1C CRIPTO3 CRIPTO ACVR1B ACVR2B CFC1 CER1 NODAL DAND5 ZIC3 DOCK1 SALL4 NANOG EPHA1 EPHA2 POU5F1 KALRN CSF1 MC4R HINT1 EDNRB UNC5A PAK4 QARS1 ZIC1 RPS6KA1 UNC5B TNFSF11 SOX9 YWHAH FOXD3 EDN1 RARS1 EDN3 TFE3 MARS1 TFEB PAX3 MITF POU3F2 YWHAZ SOX10 DARS1 MC3R LARS1 KIT TFEC EEF1E1 HDAC1 KARS1 ALX3 IARS1 MARK3 TBX3 POMC AIMP1 KDM5A UHRF1 AIMP2 FABP4 MC1R KDM6A EPRS1 STPG4 AICDA ID1 MC5R METTL23 DPPA3 SNAI2 TET3 PLIN1 VAV3 ITGAV PTK2 EBF1 EGR2 DAG1 ADIRF HOXA2 THRAP3 ISL1 ZNF638 SRPK1 PFN1 VAV2 FAM120B ZNF467 PFN2 GSPT2 LEP GSPT1 FLRT3 PRKAR2A VASP UPF3A ROBO2 NRP1 CAP1 UPF2 ENAH HSP90AB1 PABPC1 EOMES GATA6 ROCK1 CXCR4 ROCK2 TBXT AKAP5 ZSWIM8 SOX17 PAK6 GSC MIXL1 PAK5 CAP2 MYO9B ACTG1 MSI1 CUL2 ABL2 CXCL12 LHX3 LHX2 LHX4 LHX9 USP33 NCK2 NCK1 DCC ETF1 EVL SOS2 NTN1 SLIT1 SLIT3 NELL2 EPHB6 EPHB1 EPHB4 EPHB3 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 MMP2 EPHA3 MCM5 EPHA10 MCM2 EFNA5 FURIN EFNA4 PCSK6 EFNB2 EFNB1 EFNB3 EFNA1 EFNA3 EFNA2 ST8SIA4 MAG NAB1 NAB2 EIF4E EIF4B ST8SIA2 EIF4G1 CACNA1H STX1B MYL12A MYL12B CACNA1G CACNA1I MYH11 STX1A SREBF2 CLTB HIF3A MYL6 SEMA5A HSPA8 DNM2 LFNG CYP51A1 DLG1 DLG3 CACNA1C DLG4 IRS2 FGF2 FGF4 FGF7 FGF9 GAB2 ZIC2 FGF10 ITGA2 ITGA1 CSF3R GFI1 IL6R CEBPA CEBPE FLI1 KLF5 SDCBP RELN DAB1 VLDLR SIAH2 SIAH1 FES PRKACA CTCF ETS1 PAGR1 HOXA3 HOXA1 RPS6KA3 PKNOX1 RPS6KA2 HOXA4 PIAS2 HOXB3 HOXB2 HOXB1 AJUBA HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 MAP2K6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 BMI1 TPST2 KDM6B RING1 PRDM14 LIN28A ZSCAN10 CEBPB RNF2 HIRA MAPK7 CDKN2A GAB1 GRIN2B TIAM1 PLCG1 EGF BCL2 AREG AMH NOG JAG1 ADAM10 DLL1 LGI1 LGI4 CLTCL1 LGI3 LGI2 ADAM22 ADAM11 PIP5K1C ADAM23 SHANK3 GIT1 SLC2A2 PSENEN PSEN2 PSEN1 APH1A NCSTN APH1B BATF IL4R MYO5A ARPC1B ARPC1A WASL MED19 MED18 MED11 MED29 MED28 MED22 MED21 GRIN1 MYH9 SPI1 RBPJ ARPC4 ARPC5 ARPC2 ARPC3 MED13L ACTR3 ACTR2 MYO10 MYL9 GATA4 GATA3 GATA2 LIG1 PPARGC1B MMP9 MED9 CDK19 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 CNOT6L ACTL6A MED27 RPS6KA6 MED26 MED23 MED25 MED24 MED20 CEBPD EGFR MBD3 GATAD2B GATAD2A CACNG8 CACNG2 CACNG3 CACNG4 PSMD8 PSMD6 YY1 PSMD7 PSMD2 PSMD3 PSMD1 ONECUT3 ONECUT1 NEUROD1 NKX6-1 NKX2-2 PSMA5 PDX1 PSMA6 PAX4 PSMA3 PAX6 PSMA4 HNF1B PSMA1 HNF1A PSMA2 MAFA RFX6 UBA52 INSM1 PTF1A PSMD12 FOXA3 PSMD11 PSMD14 NEUROG3 FOXA2 PSMD13 MAF PSMA7 RELA PSMB6 PSMB7 PSMB4 PSMB5 DPYSL4 UBB DPYSL5 PSMB2 DPYSL3 PSMB3 UNC5C UBC UNC5D PSMB1 MEF2A AGAP2 RPS27A DSCAML1 KMT2D ADRM1 NFKB1 PLXNC1 SEMA6A SEM1 SEMA6D PSMC5 UTRN PSMC6 DLX5 SEMA7A PSMC3 RAP1GAP PSMC4 PLXNA2 PSMC1 MBP PSMC2 FOXO4 PLXNA3 FOXO1 PTPRC PTPRA PLXNB3 TREM2 MED30 ADGRV1 SEMA3A NTN4 HDAC4 SEMA3E MED31 ABLIM1 UBE2I ABLIM2 SATB1 ABLIM3 SEMA4A ARTN PRX GFRA3 RGMB GFRA2 RGMA NR5A1 GFRA4 DRP2 CD72 RXRA SCD5 SUMO1 MPZ NRTN DSCAM DOK1 RARA DOK2 PPARG TYROBP PPARA DOK4 CD36 DOK5 DOK6 BRCA1 ADGRG6 CACNA1S PRNP KAT5 PSPN HJV CRMP1 HMGCR PDLIM7 PMP22 MECOM HAND2 ITGA5 SRF TBX5 NTN3 CDH4 TRIM33 BNIP2 SMARCB1 CTNNA2 NEO1 CCNC PLK1 SPAG9 MYOG MEF2B MYOD1 CCNB1 MYF6 TCF4 CDH15 MYF5 SMARCC1 SMARCC2 SH3KBP1 SRC CDH1 CTNNB1 MET TGFA SH3GL2 SHC3 SHC1 YWHAB NRAS PCK1 FARP2 MAPK1 WT1 SMARCA2 HRAS SMARCA4 SNW1 MAPK3 MAP2K1 MAP2K2 FRS2 HNF4G MAPK14 MAPK12 HNF4A MAPK11 SOS1 PERP GCK HDAC3 MAMLD1 SMARCD3 CHD9 HELZ2 XPO1 TGS1 EP300 TBL1X MEF2D TFAP2A PPARGC1A TFAP2B NCOA1 TFAP2C MED1 NCOA2 PRM2 CREBBP PRM1 MEF2C NPM2 H1-8 NCOA6 CNOT10 SIRT1 CNOT11 TCF3 NCOR1 TBL1XR1 LDB1 CARM1 CHD4 CHD3 PPP3CB HES7 TBPL2 MESP2 MSGN1 RIPPLY2 NFATC2 PAX7 NFATC1 DLL3 INS NOTO MSX1 MTA2 YWHAE JUN MAML2 MAML1 FOXO3 SERPINE1 CDC25B MYB CDK5 CAPNS1 CAPN1 CDK5R1 MED8 MED4 MED6 MED7 NOTCH1 RBX1 NKX2-5 IHH SHH WNT9B RET RARG IAPP TNKS1BP1 DHH TCF12 NCOR2 KAT2B KAT2A TAL1 RARB WNT11 TUT7 WNT1 KDM4E TUT4 TPRX1 DUX4 WNT4 LEUTX STAT5A WNT10B TPRXL STAT5B DPPA4 TPRX2 DPPA2 ZSCAN4 DUXA DUXB WNT3A FOXA1 PAIP1 KRT1 PCGF2 POU2F1 NCOA3 USF1 RPS6KA4 ALCAM ITGA2B SCN11A DPYSL2 SCN9A NRCAM EPHB2 SCN1B RASA1 SCN1A ANK2 ANK3 ANK1 SHTN1 MEN1 SCN10A SCN8A KCNQ2 KCNQ3 EZR SPTBN4 SPTBN5 NCAN SPTA1 SCN3B SCN3A SPTBN1 SPTBN2 CNTN6 RDX MSN L1CAM KIF4B KIF4A ITGA10 CNTN1 CNTN2 CD24 SCN2A NOTCH2 SCN2B NRP2 CNTNAP1 CHL1 SCN5A CDKN1A SPTAN1 LYPLA2 CCND3 SPTB DNM1 CCND1 DNM3 E2F1 GAP43 DCX ABL1 NUMB SCN4A SCN4B ITGA9 SCN7A CCL3 TFDP1 NCAM1 RANBP9 TFDP2 NFASC CDK4 CDK2 PLXNA4 CNOT4 CDK8 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 SIN3A RPS27 CACNB1 CACNB2 CACNB3 CACNB4 HDAC5 SMARCD1 HDAC2 SMARCD2 HDAC8 HDAC9 HDAC6 HDAC7 SMARCE1 KLF4 CLASP1 HDAC10 CLASP2 HDAC11 RUNX3 DCT TYRP1 TYR PRL EIF4A2 EIF4A1 DSP DSG1 TBX21 PKP1 DSG2 DSG3 COX7A1 POLR2A SMAD2 CACNA1D POLR2B SMAD1 POLR2C SMAD4 POLR2D SMAD3 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L ACVR2A KDM5B ARID1A ARID1B H2AC19 H2AC14 IFNG H2BC12L AKT2 MYC AKT3 AKT1 ERBB2 HES1 CSNK2A1 CSNK2A2 ITGA8 CSNK2B DEK ITGB3 EPAS1 PIK3R3 PIK3R2 PIK3R1 GRB10 LYN WWTR1 KLK13 YES1 H4C9 TLN1 MOV10 AGO3 STAT6 AGO4 H2AC20 AGO1 AGO2 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs MYH9 RHOB PAK1 RHOC MYL12B CFL1 PPP1CB PPP1R12A PPP1R12B MYH11 LIMK2 LIMK1 MYH14 MYH10 MYL6 RHOA ROCK1 MYL9 ROCK2 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm RIPPLY2 DLL3 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAML2 MAML1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ADRM1 SEM1 NOTCH1 CTNNB1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SNW1 NOG LFNG DLL1 FGFR1 KAT2B KAT2A MAMLD1 TBXT TBX6 BMP4 EP300 RBPJ WNT3A CREBBP LEF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 EPHA4 PSMD1 HES7 MESP2 MSGN1 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription CDK8 HDAC10 HDAC11 CCNC UBA52 MAML2 MAML1 NBEA CUL1 NCOR2 KAT2B KAT2A HDAC3 MAMLD1 UBB MYC UBC HES1 RPS27A HES5 HEYL NOTCH1 EP300 RBX1 TBL1X RBPJ HDAC5 HDAC1 HDAC2 HIF1A CREBBP HEY1 TLE4 HDAC4 TLE2 HDAC8 HEY2 HDAC9 HDAC6 NCOR1 HDAC7 TBL1XR1 SNW1 TLE1 SKP1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle RNF139 UGGT2 VCP UGGT1 MARCHF6 EDEM3 EDEM2 SEL1L AMFR MOGS RNF103 UBA52 TRIM13 MLEC MAN1B1 RNF185 UBB UBC RPS27A UBXN1 DERL1 DERL2 CALR OS9 PSMC1 SYVN1 PDIA3 ENGASE RNF5 PRKCSH EDEM1 CANX RAD23B NGLY1 GANAB HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ELL SUPT5H CCNT1 GTF2H3 GTF2F1 GTF2F2 ELOA GTF2H4 ELOB GTF2H5 NELFB CDK7 ELOC ERCC3 NELFCD ERCC2 NELFA MNAT1 NELFE SUPT16H NCBP1 NCBP2 CTDP1 SUPT4H1 ELOA2 SSRP1 CDK9 TCEA1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes ATM ATR CCNK CCNT2 ELL CCNT1 JUN ELOA ELOB NELFB ELOC NELFCD NELFA NELFE SUPT16H FOS CTDP1 SUPT4H1 MSH2 PMS2 ELOA2 SSRP1 MLH1 CDK9 TCEA1 FANCD2 CCNH CDK12 CDK13 POLR2A POLR2B POLR2C POLR2D FANCI POLR2E DDB2 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K FANCC POLR2L GTF2H1 GTF2H2 BRCA1 SUPT5H GTF2H3 GTF2F1 GTF2F2 TP53 GTF2H4 GTF2H5 CDK7 CHEK1 ERCC3 ATF2 ERCC2 MNAT1 RAD51D MDC1 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport SLC5A2 SLC2A6 SLC2A7 SLC2A3 FGF21 SLC2A4 SLC50A1 SLC2A8 SLC5A9 SLC60A2 SLC2A10 SLC2A1 SLC5A4 SLC2A9 SLC45A3 SLC2A14 SLC2A11 SLC2A12 SLC2A2 SLC5A1 SLC5A10 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 SFTA3 CSF2RB SFTPC SFTPD CSF2RA SFTPB SFTPA1 SFTPA2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS2 EIF2S3 EIF2S2 EIF2S1 FAU RPS27A EIF1AX EIF3M EIF3K RPS15 EIF3L RPS14 EIF3I RPS17 EIF3J RPS16 EIF3G EIF3H RPS19 EIF3E RPS18 EIF3F EIF3C EIF3D EIF3A EIF3B RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS4Y2 RPS4Y1 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPS4X RPS3A RPS27L RPS15A RPS3 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment CHUK UBE2N UBE2V1 UBA52 RIPK3 UBE2D1 UBE2D2 UBE2D3 TICAM1 IKBKB BIRC2 UBB TRAF6 BIRC3 TLR3 UBC RIPK1 IKBKG RPS27A OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 UBE2D1 PSMD12 ELOB PSMD11 PSMD14 ELOC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 VHL UBE2D2 HIF3A LIMD1 EGLN1 EGLN3 EGLN2 WTIP CUL2 EPAS1 HIF1A UBE2D3 PSMD8 PSMD6 AJUBA PSMD7 PSMD2 PSMD3 PSMD1 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria PPP1R13B TFDP1 TP53BP2 TFDP2 TP73 TP63 BBC3 TP53 E2F1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs ALOX5 PTGS2 ALOX15 ALOX12 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants KIT LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation GRIA1 CALM1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B NRGN GRIN2D DLG1 GRIN1 DLG3 GRIN2A DLG4 DLG2 LRRC7 SRC NEFL NRG1 GRIA2 CAMK2G METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes AHCY TPMT MAT1A OPLAH CYP26B1 CYP26C1 FDX1 FDXR FDX2 MAOA CYP24A1 FMO3 GSS TBXAS1 GGT1 ACY1 CYP11B2 SLC35D1 CYP21A2 CYP27B1 CYP2U1 CYP11B1 CYP11A1 CYP1B1 UGT1A1 GCLC CYP2R1 GCLM UGT1A4 CYP7B1 CYP27A1 CYP4F22 CYP17A1 CYP19A1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP2U1 CYP4F2 CYP4F3 CYP2W1 CYP4A11 CYP4A22 CYP4B1 CYP4F22 CYP4F11 CYP2D6 CYP2S1 CYP3A43 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants ALK SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins MET ITGB1 HGF TNS4 TNS3 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding CALM1 PLCB3 PLCB1 PLCB2 GNG10 GNG3 GNG2 DLG1 DLG3 GNG5 DLG4 GRIK5 GNG4 GRIK3 GNG7 GRIK4 GNG8 GRIK1 GRIK2 NCALD GNGT1 GNGT2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling SOCS2 SOS1 SOCS6 SYK UBA52 FOXO3 BCL2L11 AKT2 UBB AKT3 UBC AKT1 RPS27A CBL STAT5A STAT5B HCK SH2B3 GAB2 ABL2 FLT3LG CDKN1B PIK3R1 PIK3CA LCK GRB10 NRAS HRAS SLA2 SLA FYN CSK PTPRJ FLT3 GRAP2 PTPN11 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events PRKAR2B CALM1 PRKACA PDE1C PDE1B PRKACG PDE1A ADCY4 GRK2 PRKACB PRKCD PRKCA NBEA ADCY3 PLA2G4A PRKX ADCY2 CAMK2B ADCY1 CAMK2D ADCY8 CAMK2A ADCY7 ADCY6 PRKAR2A ADCY5 PRKAR1A CAMK4 CAMK2G CAMKK1 CAMKK2 MAPK1 PRKCG KPNA2 ADCY9 PRKAR1B IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NUP93 NUP50 NUP35 NUP54 NUP160 NUP85 NUP37 SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand DNA2 PCNA LIG1 POLD3 POLD4 PRIM2 POLD1 PRIM1 POLD2 POLA1 POLA2 RPA1 RPA2 RPA3 FEN1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing SNU13 SNW1 SNRPD2 SNRPD1 SNRPD3 TCERG1 SNRPG SNRPC SRSF8 SNRPA HTATSF1 SNRPE RBM25 SNRPF SNRNP70 PRPF40A SNRPB PPP1R8 SRSF10 SRSF12 MTREX RBM39 PPIL2 NCBP1 NCBP2 PQBP1 SRRT LSM5 LSM4 LSM3 ZCRB1 SNRNP200 LSM2 LSM7 FUS LSM6 ISY1 BCAS2 CTNNBL1 PRCC HNRNPA1 HNRNPA3 TRA2B GPKOW CDC5L CCAR1 PCBP1 PCBP2 RBM10 DDX5 SUGP1 DHX15 HNRNPC DHX16 RBMX HNRNPA2B1 WBP11 PPIE PPIH PPIG DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 SMNDC1 SAP18 U2SURP HNRNPR HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD STEEP1 SF3B4 GPATCH1 SF3B5 PNN SF3B2 SF1 SF3B3 DHX8 SF3B6 PRKRIP1 SF3B1 CWF19L2 SF3A3 WDR70 SF3A1 DHX35 SF3A2 PRPF38A XAB2 SMU1 PHF5A NKAP UBL5 GCFC2 PRPF18 SDE2 FAM32A TXNL4A CACTIN SNRPN PRPF31 RBMX2 CHERP SNIP1 IK PRP4K LENG1 PRPF4 PRPF3 HSPA8 SNRNP27 ZMAT2 CCDC12 PTBP1 YJU2 PLRG1 LSM8 SNRPA1 PPWD1 DNAJC8 USP39 SART1 PUF60 TFIP11 SNRPB2 SYF2 C9orf78 LUC7L3 PPIL1 NSRP1 SNRNP40 WBP4 RNF113A MFAP1 RBM42 BUD13 PPIL3 PPIL4 FAM50A SRRM2 AQR CRNKL1 PDCD7 SNRNP35 PRPF19 SNRNP25 RNPC3 ZMAT5 ZRSR2 SNRNP48 HNRNPH1 HNRNPH2 CWC25 CWC27 EFTUD2 CWC22 PRPF6 PRPF8 CWC15 RBM5 RBM7 HNRNPU EIF4A3 CASC3 MAGOH CDC40 POLR2A POLR2B SRRM1 POLR2C POLR2D DDX39B POLR2E POLR2F POLR2G SRSF2 POLR2H SRSF3 POLR2I SRSF4 POLR2J SRSF5 POLR2K SRSF6 POLR2L SRSF7 SLU7 SRSF9 GTF2F1 RBM8A GTF2F2 SRSF1 YBX1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 ACIN1 ALYREF UPF3B MAGOHB RNPS1 DDX41 ZNF830 DHX9 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome TGFA PAG1 EREG PIK3R1 BTC PIK3CA EPGN HBEGF EGFR GAB1 PXN EGF CSK AREG SRC PTPN11 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor NTRK3 BAX NELFB DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA EGF AREG G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNGT1 PLCB3 PLCB1 PLCB2 GNG10 GNGT2 GNG12 GNG3 GNG11 GNG13 GNG2 GNG5 GNB2 GNG4 GNG7 GNB1 GNG8 GNB4 GNB3 GNB5 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system H2AC6 H2AC7 H2AX C1QBP F12 KLKB1 H3-3B H2AC19 H2AC14 H3C8 KNG1 H2BC12L H2BC26 H2BC21 H3C15 PRCP H2BC17 H2BC12 A2M H2BC13 H2BC14 H2BC15 HRG KRT1 H2BC9 H2BC8 H2BC5 H2BC11 H2BC3 H2BC1 H4C9 H2AZ1 PLAUR H2AB1 H2AC20 SERPING1 H2AC8 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SUMO2 UBA2 SAE1 SUMO1 SUMO3 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) IRAK4 BTK TLR1 S100A1 TLR6 CD36 TLR2 TIRAP S100A9 S100A8 FGB FGA MYD88 FGG TLR4 LY96 CD14 HMGB1 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAPK3 MAP2K1 MAP2K2 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 SFTA3 CSF2RB SFTPC SFTPD CSF2RA SFTPB SFTPA1 SFTPA2 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection CD3G RAC1 VAV1 IGHV3-23 IGLV ABL1 IGLV2-8 IGKV1-16 MAPK1 IGKV1-17 IGKV1-12 IGHV3-7 MAPK3 IGHV3-9 V2-11 IGHV3-30 V3-4 V3-3 V2-17 V3-2 IGHV3-33 V2-15 IGKV1D-39 V2-19 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 CRK V1-11 IGKV2D-30 V1-16 V1-13 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGKV1D-16 IGLV7-43 IGKV1D-12 IGLV1-51 NCKAP1 IGLV2-23 IGKV3-20 BRK1 CYFIP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V5-4 V1-7 V5-1 CDC42 V1-5 V1-3 IGKV3D-20 V5-6 FYN IGLV3-19 IGKV2-30 IGHV2-70 NCKAP1L IGHV2-5 IGLV3-1 WASF1 IGHV3-48 WASF2 IGLV3-25 ELMO2 IGLV3-27 IGKC DOCK1 IGLV3-21 BAIAP2 IGKV1-39 IGKV1-33 ABI2 V4-6 IGHV3-53 ABI1 V4-2 IGLC7 V4-1 IGKV5-2 IGKV1-5 IGLC6 HCK ELMO1 ACTB CYFIP2 WIPF1 WIPF2 WIPF3 BTK MYO5A ARPC1B ARPC1A VAV3 WASL PTK2 SYK WAS VAV2 IGHG3 IGHG4 IGHG1 IGHG2 MYH9 ACTG1 MYO9B NCKIPSD ARPC4 ARPC5 ARPC2 ARPC3 NCK1 FCGR3A ACTR3 LYN ACTR2 FGR MYH2 YES1 WASF3 MYO10 MYO1C CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling DPYSL2 PLXNA2 PLXNA3 FES CRMP1 SEMA3A CDK5 PLXNA1 NRP1 FYN GSK3B DPYSL4 DPYSL5 CDK5R1 DPYSL3 PLXNA4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins GGCX FURIN GAS6 F7 F9 F2 PROS1 PROC PROZ F10 BGLAP DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD CSPG5 CSPG4 NCAN BGN DCN CHST3 BCAN VCAN SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants PTPN6 TFG GZMB TPR FN1 RANBP2 JUN UBA52 IL10RA CCNB1 TYK2 DNMT1 CUL1 MDM2 RRBP1 MCL1 JUNB TWIST1 RNF213 UBB MSN IL22 UBC RPS27A CEBPB SEC31A CARS1 MAPK9 RBX1 MAPK8 RB1 CDKN1A HDAC1 KLC1 DCTN1 SQSTM1 STAT1 TPM4 TPM3 FRS3 MAPK1 STAT3 MAPK3 PLCG1 FRS2 PRF1 FOXM1 EEF1G ICOS ZC3HC1 TP53 RPS6 NPM1 IRF4 PPFIBP1 KIF5B LMO7 ALK IRS1 EML4 PPM1B HIP1 PRKAR1A PIK3CB BCL11A EIF2AK3 IL10 BCL2A1 STRN BIRC6 MYH9 STAT5A GRB2 ATIC PIK3R2 CLTC PIK3CA PIK3R1 WDCP GCC2 ZAP70 VCL MOV10 AGO3 AGO4 AGO1 AGO2 SKP1 TNRC6C RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib HSP90AA1 CDC37 ERBIN ERBB2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade CHUK PPP2CA PPP2CB FBXW11 APP JUN UBA52 CUL1 RIPK2 MYD88 RELA RPS6KA1 FOS ATF1 UBB ECSIT NKIRAS1 NKIRAS2 UBC IKBIP MEF2A RPS27A DUSP4 DUSP3 NFKB1 IRAK4 VRK3 MAPK9 NFKBIA DUSP6 MAPK8 DUSP7 MAPK7 TLR10 TLR5 LRRC14 ELK1 USP14 NLRX1 PELI3 PELI2 NFKBIB NLRC5 MAPK10 NOD1 NOD2 AGER USP18 IRAK2 MAPK1 S100A12 N4BP1 MAP3K1 MAPK3 S100B TNIP2 MAP2K1 SAA1 MAPK14 MAP3K8 MAPK11 PPP2R1B MAPKAPK3 PPP2R1A MAPKAPK2 UBE2V1 TP53 ATF2 NFKB2 HMGB1 RPS6KA5 CASP8 UBE2N TIFA TAB3 ALPK1 TAB2 TAB1 IRAK1 PPP2R5D MEF2C TRAF2 RPS6KA3 PELI1 RPS6KA2 MAP2K3 MAP2K4 IKBKB TRAF6 IKBKG BTRC MAP2K7 MAP3K7 MAP2K6 SKP1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 ITCH PSMA3 PRKACA PSMA4 PSMA1 PSMA2 PRKACG UBA52 PSMD12 PSMD11 PRKACB PSMD14 GLI1 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 SEM1 RBX1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SUFU NUMB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 BTRC SKP1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi MGAT2 CHST8 CGA LHB ST6GAL1 MGAT4C B4GALT2 MGAT4A B4GALT3 MGAT4B B4GALT1 CHST10 ST8SIA6 ST8SIA2 ST8SIA3 B4GALT6 B4GALT4 B4GALT5 MAN2A2 FUCA1 FUT3 FUT8 MAN2A1 MGAT5 MGAT3 ST3GAL4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript POM121C NUP42 NUP62 NUP43 TPR NUP88 RAE1 NUP214 RANBP2 NDC1 NUP210 NUP155 NUP153 NXF1 NUP93 NUP50 NUP35 NUP54 NUP160 ALYREF NCBP1 NCBP2 CPSF1 NUP85 CPSF4 CPSF3 EIF4E CPSF2 WDR33 NUP37 FIP1L1 SYMPK SEC13 NUP133 NUP205 POM121 NUP107 NUP188 AAAS SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT DKK1 DKK2 DKK4 H2AX PYGO1 PYGO2 SFRP1 SFRP2 ASH2L AMER1 CSNK1G2 BCL9L BCL9 CCDC88C CHD8 USP34 RAC1 CBY1 RSPO2 SOST RSPO1 RSPO4 H3-3B KREMEN1 KREMEN2 LRP5 H3C8 CXXC4 LRP6 ZNRF3 WIF1 H2AJ SRY RYK LGR6 LGR5 LGR4 PIP5K1B CTNNB1 H3C15 H2BC9 H3-4 H2BC8 H2BC5 H2BC3 SMARCA4 H2BC1 H2AB1 TLE1 TLE5 H2AC8 H2AC6 H2AC7 TCF7 CSNK1E CSNK1A1 TERT GSK3B RHOA DPY30 PARD6A XPO1 H2BC26 CTBP2 H2BC21 CTBP1 WDR5 EP300 H2BC17 DAAM1 H2BC12 H2BC13 H2BC14 H2BC15 CREBBP RAC3 H2BC11 LEF1 RBBP5 PPP3CA TCF7L2 PPP3CB H2AZ2 TCF7L1 PPP3R1 TNRC6C AXIN2 NFATC1 TNRC6A CALM1 AP2A1 TNRC6B AP2A2 AP2M1 SOX9 RBX1 YWHAZ AP2S1 WNT2B RAC2 HDAC1 GNGT1 AP2B1 GNGT2 KLHL12 HECW1 WNT5A CAV1 WNT9B WNT9A WNT16 RSPO3 WNT8A WNT8B PFN1 WNT6 GNG10 GNG3 GNG2 WNT11 GNG5 GNG4 GNG7 GNG8 WNT1 WNT2 SOX17 WNT3 WNT4 FZD1 WNT10B SNX3 FZD3 WNT10A FZD2 DVL1 FZD5 DVL2 FZD4 DVL3 WNT3A FZD7 WNT7B FZD6 TLE3 FZD8 WNT7A GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 VANGL2 GNB5 TNKS TNKS2 RNF146 CUL3 MEN1 APC CLTB PRKCG PPP2R1B PPP2R1A ZRANB1 WLS VPS29 VPS35 TMED5 VPS26A PPP2R5E SCRIB PPP2R5B CLTC PPP2R5A PPP2R5D CLTA PPP2R5C RUVBL1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 XIAP PSMD1 BTRC MAP3K7 SKP1 PPP2CA PRKCB PPP2CB PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PRICKLE1 PSMD11 PSMD14 CDC73 RUNX3 PSMD13 CUL1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 LEO1 UBC PSMB1 RPS27A ADRM1 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 KMT2B PSMC1 PSMC2 TLE4 TLE2 SMURF2 SMURF1 GNAT2 KAT5 PRKG2 PRKG1 PRKCA PLCB3 PLCB1 PLCB2 AXIN1 NLK PDE6B CAMK2A PDE6A PDE6G H2AC19 ITPR1 GNAO1 H2AC14 H2BC12L ITPR2 AKT2 SOX2 MYC ITPR3 AKT1 CSNK2A1 CSNK2A2 USP8 CSNK2B WNT5B ROR1 ROR2 PORCN ARRB2 H4C9 TRRAP SOX3 FRAT1 FRAT2 MOV10 SOX6 AGO3 SOX7 AGO4 SOX4 H2AC20 AGO1 RNF43 AGO2 CTNNBIP1 SOX13 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP11B2 CYP21A2 AKR1C1 AKR1C2 AKR1C4 CYP3A4 BENZENE METABOLISM%WIKIPATHWAYS_20260410%WP3891%HOMO SAPIENS Benzene metabolism NQO1 GSTM1 EPHX1 DHDH CYP2E1 MPO MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260410%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACADL EHHADH ACSL3 HSD17B10 ACADSB DECR1 MAPK CASCADE%WIKIPATHWAYS_20260410%WP422%HOMO SAPIENS MAPK cascade ARAF NRAS RRAS MAP2 MAPK1 MBP HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 MAPK12 MAPK10 PLCB3 RASA3 GRB2 KRAS SOS1 RAF1 LAMTOR3 SOS2 SIPA1 MAP3K12 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260410%WP585%HOMO SAPIENS Interferon type I signaling CRK IRF9 IFNAR1 MAPKAP1 PIK3R2 PIK3R1 CBL SOCS3 RAP1A SOCS1 EIF4EBP1 STAT4 FYN EIF4E EIF4B STAT1 STAT2 STAT3 PTPN11 MTOR PTPRC RPS6KB1 REL PTPN6 MAP2K6 MAP2K3 MAP3K1 MAPK14 EIF4A1 IRS1 PIK3CD CRKL RPTOR RPS6KA4 RPS6KA5 MLST8 RAC1 JAK1 IFNAR2 PRMT1 RPS6 TYK2 GAB2 VAV1 PIAS1 ZAP70 CREB1 LCK RAPGEF1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260410%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle IDH3B OGDH SUCLG2 SUCLG1 ACO2 DLD FH MDH2 SDHC SDHD SDHA SDHB CS SUCLA2 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260410%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins IL1A TNFSF6 MAPKAPK3 NFX1 MAPKAPK2 BCL2 FAS CYCS SMIM40 MAP2K4 JUN MAP3K1 RB1 PRKDC FAF1 TNF LMNB2 ACTG1 CASP9 MAPK8 PAK1 CASP8 CASP6 PS1TP5BP1 CASP10 CASP3 ARHGDIB LMNA FADD MAP3K7 SPTAN1 HEL-S-102 DFFB DFFA PARP1 APAF1 RIPK2 ACTA1 ATR SIGNALING%WIKIPATHWAYS_20260410%WP3875%HOMO SAPIENS ATR signaling ATRIP ATR RAD9A RPA3 CHEK1 RPA1 HUS1 RAD1 TOPBP1 RAD9B MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260410%WP4318%HOMO SAPIENS Mitochondrial fission and fusion FIS1 OPA1 MTFP1 BNIP3 MFN1 BAX MFN2 SH3GL2 BCL2L1 MIB1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260410%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 CASP2 TNFSF6 RIPK1 FAS CYCS CASP9 CASP8 CASP6 CASP3 FADD MAP3K1 APAF1 NFKB1 TNFRSF1A AIFM1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260410%WP4842%HOMO SAPIENS Mammalian disorder of sexual development EMX2 RBFOX2 AMHR2 DMRT1 DHH CBX2 FST GATA4 FOXL2 PBX1 NR5A1 MAPK11 FGF9 WT1 CTNNB1 SOX8 SOX9 SRY RSPO1 INSL3 AMH FGFR2 WNT4 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260410%WP4297%HOMO SAPIENS Thiamine metabolic pathways OGDH BCKDK PDHA1 TPK1 HEL107 SLC19A3 DKFZp667O1614 SLC19A2 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260410%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway MTMR1 PI4K2B MTMR2 PTEN MTMR8 PIK3C2G PIK3C2A STM7 MTMR6 PIK3C2B MTM1 PIP4P2 PIP4P1 INPP5D INPP5E PLCG2 PIP4K2A PIP5K1A PLCE1 PIP4K2B PLCG1 PIP5K1C TPTE2 SACM1L IPMK OCRL FIG4 INPP4A INPP4B PIKFYVE PLCB4 PIK3CA PI4KB PLCB3 PLCD3 PLCB1 PLCB2 PLCD4 PI4K2A PIK3CD METHYLATION PATHWAYS%WIKIPATHWAYS_20260410%WP704%HOMO SAPIENS Methylation pathways PNMT NNMT TPMT MAT1A INMT HEDGEHOG SIGNALING%WIKIPATHWAYS_20260410%WP47%HOMO SAPIENS Hedgehog signaling ADRBK1 PTCH2 IHH SAP18 KIF7 GLI3 DHH SHH SMO SIN3A SUFU PTCH1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation BMP2 RBL1 FGF18 SNAI1 FGFR3 STAT1 MAPK1 MAPK3 MAP2K1 MAP2K2 MAPK14 MAPK12 RAF1 MAPK11 FGF9 IHH SOX9 CDKN1A CNP THRA NPR2 PTH1R PTHLH PPP2CA ATG5 MAPK13 BMP4 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260410%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress NQO1 IL1A PTEN ATF2 BCL2 CXCL8 KEAP1 NRF1 PTGS2 FOXO1 CHEK1 IKBKB HMOX1 IKBKG MAP3K5 GSX1 NOS2 TSC1 ATR FOS IPCEF1 MTOR SIRT1 PINK1 IL6 MAP2K3 RHEB MAP2K4 CCNE1 PIP CDK2 MDM2 BCL2L1 NFE2L2 NFKB1 MAPK14 PIK3CA TNF MAPK8 RPS6KA5 CDKN1A CREB1 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260410%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 LRP6 PORCN CREBBP LRP5 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation MXI1 NCKAP1L NFE2 RIOK3 NFATC2 XB MHC2TA FLI1 ARHH KLF1 GP9 IL3 KITLG IL5 FOSB IL1A FOS IL6 CSF3 CSF2 SPI1 TRAF3IP3 CSF1 EPO ITGB3 ITGA2B IKZF1 LYL1 HMGN5 TRIM29 MYB PIM1 CD34 HES6 LMO2 CBFA2T3 RUNX1 IL1B ZNF835 NOTCH1 LEF1 CXCR4 GATA2 VAV1 ACVR1B GATA1 ABO NR1A2 TPO MUC1 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260410%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH UXS1 GFPT1 PGM3 GCK HK2 HK3 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260410%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte BMP7 BMP2 LEP ZIC1 PRDM16 DKFZp781O1323 PPARG HOXC9 ZNF423 PPARGC1A HOXC8 PPARGC1B MPZL2 CEBPA SMAD1 DGIC CEBPB CEBPG HSPB7 CIDEA SMAD9 EBF3 SLC7A10 BMP4 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260410%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C HEL-S-30 HEL-S-133P PFKP TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260410%WP3851%HOMO SAPIENS TLR4 signaling and tolerance TLR4 MYD88 CXCL8 IKBKB INPP5D IKBKG IL6 NFKB1 RIPK1 TNF TRAM1 TBK1 IRAK1 IKBKE CHUK IFNB1 IRAK3 MAP3K7 IRAK4 TICAM1 TIRAP NFKBIA MAP3K7IP1 IRF3 TRAF3 TRAF6 IRF7 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes SCARB1 SLC27A1 PCSK9 DBI LIPA APOE APOB LDLR ACSL3 ABCA1 MYLIP STARD3 ACSL1 SORT1 ACSL6 ACSL5 APOA4 FABP1 FABP2 FABP4 SOAT1 STAR SOAT2 NPC2 APOC2 APOC1 SLC27A3 LPA SLC27A2 SLC27A4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome RAD50 PAXIP1 RAD21 MRE11A ATM BRCA1 NBN SMC3 SMC1A RAD18 MDC1 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260410%WP2374%HOMO SAPIENS Oncostatin M signaling PIK3R1 SOCS3 STAT1 STAT3 PTPN11 MTOR CEBPB MAPK8 CASP3 NFKBIA MAPK1 FOS HRAS MAPK3 MAP2K1 CDK2 MAP2K2 NFKB1 MAPK14 GRB2 KRAS SOS1 RAF1 CDKN1B JAK3 IRS1 JUNB PRKCH PRKCB PRKCE PRKCA OSMR IL6ST SRC JAK1 PXN HIF1A RELA RPS6 MAPK9 TYK2 PTK2B RICTOR EGR1 STAT5B JUND CREB1 OSM VEGFA INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260410%WP1971%HOMO SAPIENS Integrated cancer pathway BLM BACH1 BBC3 PTEN CHEK2 MYC SMAD2 BCL2 BARD1 CDKN2B POU2F1 BAD CHEK1 PLK1 CDC2 CDC25B MSH6 MAP3K5 MSH2 STAT1 CDK4 NOXA1 ATR BAX CDK2 MDM2 RAD50 MRE11A ATM BRCA1 RB1 CDKN1B CASP9 CASP8 CASP3 JAK1 CDKN1A ATF1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260410%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis PPARGC1A LDLR ABCA1 PRKAA1 HMGCS1 NR1H3 MTOR NR1C1 SIRT1 SIRT6 HMGCR MED15 SREBF2 SCD FASN 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP4 NIPA2 CYFIP1 FMR1 TUBGCP5 NIPA1 TUBGCP6 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260410%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling PIK3R2 PIK3R1 RAP1A STAT1 CDK4 STAT3 MTOR RPS6KB1 PIK3CA IGF1R PLCB1 CCND3 RPS6KA1 TSHB RB1 PDPK1 PDE4D SCRIB RBL2 GNAI3 ADCY3 GNAI1 RAP1GAP MYL12B GNA13 GNG2 CGA KCNIP3 TSHR GNAO1 APEX1 GNB1 GNAS MAPK1 HRAS MAP2K6 MAPK3 MAP2K3 CCNE1 MAP2K1 CDK2 BRAF MAPK14 RAF1 CDKN1B SRC JAK1 RPS6 CREB1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP561%HOMO SAPIENS Heme biosynthesis ALAS2 ALAS1 FECH UROD UROS HMBS CPOX ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260410%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD LPL NQO1 AHR EGFR PLAGL1 MYC CYP1B1 EP300 CCL1 CD36 FGF21 PTGS2 AIP NCOR2 KLF6 GCLC CDC37 NRAS NF1 CYP1A1 AHRR MAPK1 NCOA7 HRAS MAP2K1 CDK2 NFE2L2 NFKB1 KRAS RB1 RAF1 TNF CDKN1B SRC CDKN1A RELA VEGFA RET STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260410%WP383%HOMO SAPIENS Striated muscle contraction pathway MYOM1 HEL113 HEL-S-273 TTN TNNI1 TNNI2 TNNI3 DMD HEL-S-108 MYBPC3 TMOD1 ACTN2 TPM3 TNNC1 TPM1 TNNC2 ACTN4 ACTA2 MYL4 MYL1 TNNT1 MYL2 MYL3 TNNT3 MYH8 ACTG1 TCAP MYH6 tmp_locus_29 ACTA1 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260410%WP5193%HOMO SAPIENS Cholesterol synthesis disorders IDI1 FDPS MVK HSD3B2 HMGCS1 CYP51A1 DHCR24 MSMO1 SQLE HMGCR EBP PMVK SC5D MVD DHCR7 LBR FDFT1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260410%WP2324%HOMO SAPIENS AGE RAGE pathway MMP2 MMP9 DDOST MMP14 EZR ROCK1 SMAD2 FOXO4 AGER PRKCZ INS CDC42 MSR1 INSR INHBB HEL-S-44 STAT1 ARHA SP1 STAT3 ALPL CASP9 MAPK8 CASP8 CASP3 CHUK IRAK4 TIRAP NFKBIA MYD88 EGFR ATF2 CYCS FOXO1 IKBKB NOS2 MAPK1 MAPK3 JUN MAP2K1 NFKB1 MAPK14 RAF1 IRS1 PRKCB PRKCA RAC1 SRC HIF1A RELA MAPK9 STAT5B NCF1 HEL70 MMP7 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260410%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 STAT3 MMP9 CHI3L1 IL6ST MYC SOCS3 BAX STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP496%HOMO SAPIENS Steroid biosynthesis HSD3B2 HSD17B1 HSD17B2 HSD3B1 HSD17B3 HSD17B4 F13B HSD17B7 CYP17A1 CPN1 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260410%WP4496%HOMO SAPIENS Signal transduction through IL1R IL1A MYD88 IKBKB MAP2K6 IL6 MAP2K3 JUN MAP3K1 IL1RN IFNA1 NFKB1 ECSIT MAPK14 IRAK2 TGFB1 IL1R1 MAP3K14 TNF MAPK8 IRAK1 CHUK IL1B IFNB1 RELA IRAK3 MAP3K7 NFKBIA MAP3K7IP1 TRAF6 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway GGPS1 IDI2 ACAT2 ACAT1 HMGCL IDI1 FDPS MVK HMGCS1 HMGCR PMVK MVD FDFT1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260410%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling BCL2 BAD FOXO1 IKBKG MAPK1 MTOR MAP2K1 MDM2 MAP2K2 NFKB1 CREBBP PIK3CA GRB2 KRAS SOS1 RAF1 GSK3B PDGFA CDKN1B KLK3 CCND1 CASP9 AKT3 CTNNB1 CDKN1A NFKBIA KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260410%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary MMP9 NRAS MAPK1 HRAS MAPK3 HSD3B1 STAR MAP2K1 MAP2K2 NFKB1 PLCB4 PIK3CA PLCB3 PLCB1 PLCB2 KRAS RAF1 PIK3CD ARRB2 PRKCH BMP15 PRKCB CYP11A1 PRKCE KISS1R PRKCA KISS1 GDF9 FSHR PRKCQ AMH EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260410%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TGFB1 ERBB2 MFGE8 EGFR MET CD133 KRAS SMAD2 RAF1 NRAS CTNNB1 MTOR HRAS SMAD4 WNT3A HGF AXIN1 TGFA TGFBR1 TGFBR2 DKK4 TGFBR3 TSPAN8 APC LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CDK8 HNRNPK CDK6 NOTUM MYC TCF3 CSNK1A1L EZH2 CCND3 GSK3B CCND1 WNT3A MAP3K7 AXIN1 DKK4 APC WNT2B CHD8 FZD10 FRAT1 FRAT2 CCND2 SOX17 RUVBL1 SOST CER1 APC2 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E AXIN2 WNT16 SENP2 DKK1 JUN DKK2 SFRP4 SFRP1 SFRP5 PORCN CSNK2B ROR1 LRP5 ROR2 LRP6 ATF3 CTBP2 CTBP1 MACROH2A2 NLK CXXC4 NKD1 NKD2 WIF1 DVL1 DVL2 DVL3 WNT1 WNT3 FZD1 TFAP2A CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 LEF1 FZD5 WNT4 CSNK1A1 RYK WNT7B FZD7 FZD9 WNT7A FZD8 FOSL1 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260410%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260410%WP5087%HOMO SAPIENS Pleural mesothelioma NOTUM PTEN CSNK1A1L EZH2 SPARC RPS6KA3 RASSF1 RASSF2 RASSF3 RASSF4 RASSF6 KDR LGALS9 BTRC PRKAB2 FLT3LG PRKAB1 HCFC1 BTC DDIT3 ULK2 ULK1 IDO1 EPHA2 TERT PLCB4 PDGFD PIK3CA PDGFC STK38L WWTR1 NGFR PHC1 SETDB1 IGF2 RASSF7 IGF1 BAP1 SETD5 SETD2 PRKAG1 PRKAG2 LIMD1 BMI1 AREG PRSS23 PRKAG3 FGF8A TEAD2 GABPA CDKN1A TEAD3 TEAD4 MAP4K1 IL10 MAP4K2 MINK1 KIF23 FGF7B CIT SLC7A5 FGF7A KIT CD47 FGF18 PIGF VGLL4 FGFR3 ATF2 CD44 HBEGF YAP1 FGF6B NTF4 NTF3 FOXO1 CTNNA1 PAK6 CTNNA3 CTNNA2 MAP3K5 MEF2D MAP4K3 PAK4 TSC1 SUZ12 CDKN2A IL34 VEGFB FGF5C IL6 VEGFC RHEB VEGFD CCNE1 MAD2L1 WWC1 CDK2 CDH9 MDM2 FGF2 ACTG2 PORCN CDH8 CTGF LRP5 AMOT LRP6 CSF3 CDH6 CSF2 YY1 CDH4 FGF7 CSF1 FGF8 DEPTOR CDH2 ITGB3 MAP3K6 HMGN1 PDGFRA TSC2 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 TNIK AJUBA IL1B MAD1L1 DSC3 CSF1R MAX LEF1 KMT2C EFNA5 EFNA4 BAG2 FGF20 CDH24 NLRP3 FGF23 MAP2K5 FGF22 MCL1 BDNF SELE EFNA1 MOB1A EFNA3 CDK7 LIN28B FGF14 CXCL12 KITLG EFNA2 MAP3K10 MDM4 NF2 FGFR4 FGF13 FGF12 OGT MCU MAP3K11 EIF4G1 FGF10 FGFR1 ITGB1 FLT1 ITGB4 FLT3 HEL-S-31 FLT4 LAMC2 CXCL1 HMGB1 LAMC1 FOXM1 CXCL5 PRB1 MDK RB1CC1 PPARGC1A PRB2 WDR5 HEL-S-1 ITGAV ITGA4 EED ITGA2 MMP3 ITGA1 TRAF2 NGF TTI1 LATS1 LATS2 CDH10 CDH11 AKT1S1 CDH12 ITGA6 CDH15 CDH16 CDH17 CDH18 CDH19 LAMA5 PRKAA2 LAMA1 UHRF1 LAMA4 LAMA3 SLC3A2 RNF2 MAPK7 RBBP4 CCL5 CCL4 CCL2 BAK1 CTHRC1 NTRK1 NTRK2 ANGPT4 MOBKL1A ANGPT2 FABP4 LAMB3 ANGPT1 EGF LAMB2 LAMB1 ASXL1 RPS6KB2 ATM BRCA1 SRC HIF1A MAPK9 VEGFA BBC3 MYC BARD1 CDK4 PRKAA1 IGF1R CCND3 RPS6KA1 EGFR FGF21 MAPK1 HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK10 GRB2 ACTA2 SOS1 TNNT1 RAF1 PIK3CD RPTOR RPS6KA5 MLST8 JAK1 RPS6 CREB1 MMP2 MMP9 MMP14 AGER INS EIF4EBP1 INSR EIF4B STAT1 SP1 MTOR RPS6KB1 TGFB1 GSK3B PDGFA ACTG1 CCND1 AKT3 MAPK8 PAK1 PS1TP5BP1 WNT3A HGF AXIN1 TGFA DKK4 ACTA1 APC MET MAPKAPK2 WNT2B BCL2 CHD8 FZD10 FRAT1 CYCS FRAT2 CCND2 SOX17 SOST CER1 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 KREMEN1 CSNK1E WNT16 SENP2 BAX DKK1 DKK2 SFRP4 SFRP1 SFRP5 NFKB1 CSNK2B ROR1 ROR2 ATF3 CTBP2 CTBP1 CXXC4 WIF1 DVL1 DVL2 DVL3 WNT1 FGF9 WNT3 FZD1 CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 FGFR2 CSNK1A1 WNT4 RYK WNT7B FZD7 FZD9 WNT7A FZD8 FOSL1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260410%WP3287%HOMO SAPIENS Overview of nanoparticle effects CCND3 LAMA3 BCL2 CXCL8 PTGS2 TNF AKT3 HMOX1 PIK3CD COL4A1 IL6 BAX CRP PTGS1 NFRKB WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP4149%HOMO SAPIENS White fat cell differentiation INS FOXO1 CTNNA1 NR1H3 CEBPA CEBPB DDIT3 CEBPD RORA GATA3 NR3C1 EVI1 TLE3 EGR2 NR2F2 PPARG KLF4 ZNF423 KLF15 KLF2 KLF5 IRF4 RARA WNT10B TCF7L1 GATA2 STAT5B IRF3 CREB1 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 UGT8 GNPAT PEX7 PEX5L PEX3 DHRS7B AGMO AGPS FAR1 CEPT1 LPIN1 LPIN2 ACAD10 LPIN3 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260410%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 HSD3B1 STAR CYP17A1 CYP11A1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260410%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 CYP1B1 AKR1C1 AKR1C2 AKR1C4 HEL-S-165mP CYP1A1 CYP3A4 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260410%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing RNASEH2C RNASEL RNASEH2B RNASEH2A TREX1 RNASET2 CGAS ADAR MITA IFIH1 MAVS OAS1 RIGI IFNB1 IRF3 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260410%WP3929%HOMO SAPIENS Chemokine signaling CXCL13 CXCL14 CXCL16 PREX1 PRKACG FOXO3A TIAM1 ADCY9 PARD3 ELMO1 SHC4 SHC2 SHC3 PIK3R3 IL8RB PIK3R5 GRK1 GNG10 PLCB4 GRK5 PIK3CA GRK4 CCR10 LYN PLCB1 CCR1 PLCB2 XCR1 PPBP GNG12 GNG11 GNG13 CXCL11 GNB2 GNAI3 GNB4 ADCY3 GNB3 GNAI1 GNB5 NFKBIB ITK CXCL9 GNG2 ADRBK1 WASL CXCL3 CX3CL1 GNGT1 GNGT2 GNB1 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 VAV3 VAV2 XCL1 DOCK2 CX3CR1 CCL11 ROCK2 CXCR5 WAS PRKX ADCY1 CCL1 CXCR6 ADCY8 ADCY6 GNG3 IKBKB CCL7 GNG5 IKBKG GNG4 NRAS CXCR3 GNG7 CCL3 MAPK1 GNG8 CSK HRAS CCL19 CCL17 MAPK3 CCL15 CCL25 CCL24 CCL22 CCL21 MAP2K1 CCL20 c-fgr CCL28 BRAF CCL27 PF4 CCL26 PLCB3 GRB2 KRAS SOS1 RAF1 SOS2 PIK3CD CRKL RAC1 CXCR4 VAV1 NCF1 CRK PIK3R2 PIK3R1 ROCK1 PRKCZ RAP1A CDC42 CXCL12 STAT1 STAT2 STAT3 CXCL5 GSK3B AKT3 ARRB2 PAK1 CHUK NFKBIA CCL5 CCL4 NFKB1 JAK3 PRKCB PXN RELA PTK2B STAT5B CANCER PATHWAYS%WIKIPATHWAYS_20260410%WP5434%HOMO SAPIENS Cancer pathways VHL CAMK2G HES5 PTEN LAMB4 EPOR PLCG2 PLCG1 PLCB4 PIK3CA PLCB1 PLCB2 SHH SMO SUFU PTCH1 PTCH2 KIF7 GLI3 CDKN1A BMP4 BMP2 FGFR3 CXCL8 KEAP1 PTGS2 FOXO1 IKBKB HMOX1 IKBKG NOS2 FOS IL6 CCNE1 CDK2 MDM2 NFE2L2 CREBBP LRP5 LRP6 SPI1 EPO ITGA2B PIM1 RUNX1 NOTCH1 LEF1 CXCR4 IL3 KITLG IL5 CEBPA PPARG CHUK NFKBIA TRAF3 TRAF6 CDKN1B JAK3 PRKCB PRKCA IL6ST HIF1A RELA MAPK9 STAT5B VEGFA BBC3 MYC SMAD2 CDKN2B BAD MSH6 MSH2 CDK4 IGF1R CCND3 GNAI3 ADCY3 GNAI1 GNA13 GNG2 GNB1 GNAS RET EGFR EP300 TPM3 MMP2 ROCK1 ARHA SP1 IFNA1 TGFB1 GSK3B PDGFA KLK3 CCND1 AKT3 SMAD4 WNT3A HGF AXIN1 TGFA TGFBR1 TGFBR2 APC ERBB2 MET WNT2B FZD10 FRAT1 FRAT2 CCND2 APC2 WNT5B AXIN2 WNT16 CTBP2 CTBP1 DVL1 DVL2 DVL3 WNT1 WNT3 FZD1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 WNT7B FZD7 FZD9 WNT7A FZD8 CDK6 RASSF1 FLT3LG TERT IGF2 IGF1 KIT CTNNA1 CTNNA3 CTNNA2 CDKN2A VEGFB VEGFC VEGFD PDGFRA COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 CSF1R MAX CXCL12 FGFR4 FGFR1 ITGB1 FLT3 FLT4 LAMC2 LAMC1 ITGAV ITGA2 MMP3 TRAF2 ITGA6 LAMA5 LAMA1 LAMA4 LAMA3 BAK1 NTRK1 LAMB3 EGF LAMB2 LAMB1 RPS6KB2 EVI1 RARA PRKACG ADCY9 PIK3R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB4 GNB3 GNB5 GNGT1 GNGT2 NQO1 GSTM1 ROCK2 ADCY1 ADCY8 ADCY6 GNG3 GNG5 ARAF GNG4 NRAS GNG7 MAPK1 GNG8 HRAS MAPK3 JUN MAP2K1 MAP2K2 BRAF HEL-S-125m MAPK10 TFG PLCB3 KPG_010 DAPK2 GRB2 BCR KRAS EML4 SOS1 AGTR1 RAF1 JAG2 GSTM4 SOS2 GSTM3 GSTM2 JUP FZD4 IF1AA9 PIK3CD GSTM5 CRKL HEY2 ELOC APPL1 RPS6KA5 IFNGR1 IFNGR2 RAC1 JAK1 WNT9B WNT9A IFNAR2 F2 DDB2 PAX8 RARB WNT8A WNT8B IL12RB1 RUNX1T1 EGLN1 EGLN3 EGLN2 CRK CCDC6 CSF3R IFNAR1 IL5RA PIM2 PIK3R2 IL13RA1 PIK3R1 IFNA13 CBL IFNA14 IFNA16 IFNA17 F2R STAT4 RBX1 MSH3 IFNA10 NOTCH2 STAT1 NOTCH3 STAT2 GSTT2 STAT3 KNG1 BCL2L11 TPR MTOR IFNA21 ZBTB16 RPS6KB1 NFKB2 ALK FH HSP90AB1 NKX3-1 PLEKHG5 TRAF1 TRAF4 TRAF5 IL3RA BIRC5 CCDC42 BIRC7 BIRC2 BIRC3 HDAC2 HDAC1 RB1 IL2RG E2F2 E2F3 TXNRD3 TXNRD2 PML RAD51 CASP9 IL2RA MAPK8 IL2RB CALML6 CASP8 HHIP CALML3 CALML4 EDNRA CASP3 EDNRB IL12B IL12A FADD SKP2 SKP1 IL15RA IL23A MGST3 LPAR1 APAF1 MGST1 MGST2 LPAR2 LPAR3 TNFSF6 LPAR4 GSTT2B GADD45B GADD45A BCL2 GADD45G IFNA4 FAS IFNA7 CYCS IFNA6 IFNA2 BRCA2 IFNA8 RAC3 NCOA1 EDN1 IL15 IL13 ARHGEF1 PTGER4 PTGER1 PTGER2 PTGER3 RXRB RXRA RXRG BAX ARNT2 GSTA5 BCL2L1 GSTA4 GSTA3 NFKB1 F2RL3 IL6R RALBP1 NR3A2 CCNE2 CSF2RB CSF2RA RASGRP4 PLD2 RASGRP3 PMAIP1 IL2 IL4 IL7 IL7R NR1C2 CKS1B BDKRB2 BDKRB1 CTNNB1 POLK ARHGEF11 ARHGEF12 HEL-S-21 DCC HEL-S-22 CCNA2 FGFR2 IFNG WNT4 RALA CAMK2D RALB CAMK2A DLL3 DLL4 GNA11 HES1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260410%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 TMPRSS2 CXCL8 ACE2 IL2 TNF IL7 CCL2 IL2RA CCL3 IL1B IL6 IL10 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260410%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MLST8 FOXO3A EGFR MAPKAP1 PTEN MTOR RPL11 RIOK2 RICTOR RIOK1 AKT3 PIK3CA MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260410%WP2003%HOMO SAPIENS miR targeted genes in leukocytes CDK6 ADAR SERPINE2 PLXND1 ARID4B DCAF7 TXN2 PNP CHORDC1 MAP3K8 GOLGA7 CDK5RAP3 FADS1 VPS39 ATP6V0E1 TNLG5A IFRD1 HEL-S-66 PISD MTHFD2 RAB34 PPIF PPIB ANAPC1 POM121 DDX5 RAB5C TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 RDH10 KCNN4 SAC3D1 MPDU1 ATP6V1F SNX6 CD164 GNA13 PHC2 BRPF3 HMGA1 TBCA IGF2R BCL6 MENT SFXN1 SLC25A1 ARF4 ADPGK SNAP23 TNFAIP2 ATP2A2 SLC7A11 PRSS21 LPL MRC2 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 TMED3 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC HMOX1 SCYL1 CAP1 ANXA2 PRPF40A HEL-S-26 SLC7A6 CDCP1 RFT1 FRG1 PTRH1 UNC93B1 TYMS THBS1 HEL-S-47e PTPA DNAJB1 POLR2C USP1 TPM3 SHOC2 MAPK14 CDIPT SRSF10 CA12 AP3D1 ARHG ARCN1 WDR11 POLE4 FMNL2 LAMTOR3 MCL1 CEBPB LMNB2 HEL-S-30 TRAM1 BCL2 CTNNB1 EGF EGFR SIGNALING%WIKIPATHWAYS_20260410%WP437%HOMO SAPIENS EGF EGFR signaling PTEN PIK3C2B RPS6KA3 INPP5D PLCE1 PLCG1 RPS6KA1 PDPK1 MAP4K1 VAV3 VAV2 EGFR FOXO1 MEF2D MAPK1 FOS CSK HRAS MAP3K2 JUN MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 GRB2 KRAS SOS1 RAF1 USP6NL SOS2 SH3GL3 ERRFI1 NDUFA13 INPPL1 CBLC CRKL GJA1 RPS6KA2 GRB10 RPS6KA5 AP2M1 PRKCI MEF2C RAC1 HGS JAK1 STAMBP RIN1 STAM2 STXBP1 SH2D2A GAB2 IQGAP1 VAV1 HEL-S-15 ATXN2 COX2 CREB1 CAV2 TNK2 MAP2K5 PTK6 CRK SYNJ1 RAB5A HEL-S-34 PIK3R2 AP2A1 PIK3R1 NCK2 ROCK1 FOXO4 NCK1 CBL EPS15L1 PRKCZ RAP1A EPN1 PLSCR1 EIF4EBP1 PXDN CDC42 ARF6 PCNA ASAP1 NEDD8 FOSB AP2S1 STAT1 SP1 REPS2 MAPK4 STAT3 LIMK2 PTPN11 MTOR ITCH NEDD4 RPS6KB1 SPRY2 PTPN5 MAPK8 PAK1 ERBB2 MAPK7 ARHGEF1 EGF SH3GL2 RALBP1 PLD2 PRKCB PRKCA SRC MAPK9 RALA PTK2B RICTOR RALB STAT5B CAMK2A JUND ATF1 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260410%WP5093%HOMO SAPIENS Opioid receptor pathways FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHDC2 ECHS1 ACSL3 DECR1 ACSL1 ACSL6 ACSL5 PECR MECR ACSS2 SCD FACL4 FASN ACACB ACACA ACLY PC ECHDC1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260410%WP5174%HOMO SAPIENS Ulcerative colitis signaling TGFB1 GATA3 NFATC1 NOD2 FOXP3 HLA-DMA MAF IL2RG TNF IL4 IL5 IL13 IFNG IL10 NFKB1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260410%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway NCKAP1L PIK3R2 PIK3R1 PIK3C2A RAC3 PLCG2 PTPN6 PIK3R3 PIK3CA LYN C1QB C1QA ITGAM NCF2 ARPC1B NCF4 TREM2 PIK3CD TREM1 FCGR1A FCER1G SYK CYBB CYBA RAC1 TYROBP SIGLEC7 LAT C1QC VAV1 VAV3 NCF1 VAV2 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260410%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IL1A TLR4 MYD88 IRAK1 HEL-S-71 TLR1 JUN TIFA TLR9 TLR8 TLR10 NFKB1 TLR7 TRAF6 UBE2V1 TLR5 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260410%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma TFEB HMGB1 PARK2 VMP1 IPO8 DKFZp762B153 KRAS SQSTM1 AGER STAT3 PINK1 MDM2 NFE2L2 NFKB1 SHOC2 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5102%HOMO SAPIENS Familial partial lipodystrophy LPL ZMPSTE24 LIPE FNTA INS BANF1 ICMT PRRX1 CIDEC KLF9 PLIN1 MGLL PNPLA2 NR1C1 FABP4 CEBPA CIDEA PIK3CA GATA3 PPARG KLF2 KLF5 LMNB2 LMNA MAPK9 GATA2 STAT5B MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260410%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis YAP1 SPARC PBX3 TWIST1 THBS2 EDNRA COL1A1 TEAD2 COL3A1 SNAI2 TEAD3 TEAD4 GPC6 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260410%WP430%HOMO SAPIENS Statin inhibition of cholesterol production LPL SCARB1 APOE APOB LDLR ABCA1 APOA4 SOAT1 HMGCR MTTP CYP7A1 APOC2 LIPC APOC1 ACSS1 PLTP PDIA2 ABCG8 ABCG5 DGAT1 APOA2 APOC3 APOA5 SQLE FDFT1 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP75%HOMO SAPIENS Toll like receptor signaling IFNAR1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 STAT1 MAP3K8 IFNA21 IFNA1 TNF CXCL11 AKT3 MAPK8 NFKBIB CASP8 CXCL9 TBK1 IRAK1 IKBKE CHUK IL12B IFNB1 IL12A FADD MAP3K7 IRAK4 TICAM1 TLR1 TIRAP TLR9 NFKBIA TLR8 MAP3K7IP1 IRF3 TRAF3 TLR7 TRAF6 MAPK13 IRF7 TLR5 TLR4 MYD88 IFNA4 CXCL8 IFNA7 IFNA6 IFNA2 CCL5 IFNA8 IKBKB CCL4 IKBKG CCL3 MAPK1 FOS MAP2K6 MAPK3 IL6 MAP2K3 MAP2K4 JUN MAP2K1 MAP2K2 NFKB1 MAPK14 MAPK12 MAPK10 RIPK1 CD40 CD80 LBP TICAM2 TLR3 LY96 SPP1 CD14 TAB3 IF1AA9 MAPK11 RAC1 IL1B IFNAR2 RELA MAPK9 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260410%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPS17 RPS6KA6 RPS16 RPL18A RPS19 RPS18 RPL36 RPL35 RPL11 RPLP2 RPL38 RPL37 RPS6KA3 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPS6KB1 RPL22 RPL13A RPS3A RPSA RPL37A RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPS6KA1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPS27A RPL17 RPL19 RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPS6KB2 HEL-S-310 RPL4 RPL5 RPS6KA2 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPS6 RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260410%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus GALNT16 CERK SGMS1 SPHK2 SPHK1 GALNT1 SGMS2 SGPP2 SGPP1 UGCG SGPL1 B3GALT2 B3GALT1 B4GALNT1 KDSR UGT8 B4GALT2 CERS3 B4GALT1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260410%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders FLAD1 SLC52A2 ETFDH SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 COQ2 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260410%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination ROCK1 GADD45G FRAT1 GSK3B FOXL2 MAPK11 FGF9 ARHA CTNNB1 MAPK1 SOX9 SRY FGFR2 AXIN1 WNT4 MAP3K1 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260410%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction HEL-S-80p CALM1 ROCK2 PLCB1 ROCK1 MYL1 ARHA IL13 RYR1 PPP1R14A GDI1 ADRB2 MYLK OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260410%WP322%HOMO SAPIENS Osteoblast signaling IBSP BGLAP COL1A1 PTH TNFSF11 TNFRSF11B ITGB3 SLC17A2 PDGFRA PTH1R ITGAV FGF23 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260410%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin MCL1 IL3 CXCL12 IL2RG TNF CXCL11 ITGA4 IL2RB CX3CL1 IL10 IL15RA BCL2 CXCL8 CCL5 CCL7 CCL4 CCL2 CXCR3 IL15 CCL3 ANGPT2 MAPK3 ANGPT1 IL6 MAP2K4 NR3A2 NR3C1 MRC1 MADCAM1 IL4 GAB3 JAK3 HLA-G NCR1 NCR2 MAPK11 NCR3 PGR KIR2DL4 CCL8 PIBF1 VCAM1 JAK1 SELL CD69 IFNG CXCR4 GATA2 STAT5B VEGFA AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260410%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-87p PGAM2 GPT ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-30 HEL-S-49 HEL-S-133P SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260410%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis HES7 EPHA4 RIPPLY2 TBX6 NOTCH1 DLL3 MESP2 LFNG PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260410%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma PTEN CHEK2 JMJD1C MYC TLK1 HIST1H1E MYBL1 CMTR2 MAGI1 KDM6B FBXW7 ARID4B HIST1H2AK INSRR ARID5B ARID1A FOXP2 FGFR4 MORF4L1 FOXO3A NCOR1 KAT6A MAML3 BCORL1 CEBPA MYCBP SRCAP DTX4 SMARCE1 MGA ERBIN FGF16 KANSL1 NFIB PIK3CA BCOR PRKDC SETD2 ERBB2 UHRF1 EP300 CHEK1 HRAS MAP2K2 CREBBP CTBP1 ATM BRCA1 RAF1 SMC1A MYB NOTCH1 MAX KMT2C MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260410%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission PTEN BDNF AP2A1 PIK3R2 ROCK1 PIK3R1 ARHA NTRK2 STAT3 PLCG1 PIK3R3 PIK3CA GABRB3 GABRB2 GABRB1 CREM NGFR AP2A2 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG2 GABRG1 CREB1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260410%WP438%HOMO SAPIENS Non homologous end joining WRN XRCC5 POLM POLL NHEJ1 PRKDC RANKL RANK SIGNALING%WIKIPATHWAYS_20260410%WP2018%HOMO SAPIENS RANKL RANK signaling PIK3R2 PIK3R1 SQSTM1 CBL CDC42 IKBKB IKBKG STAT1 MAPK1 FOS MTOR PLCG1 MAP2K6 MAPK3 NFKB2 JUN MAP2K1 TRAF1 NFKB1 TRAF5 MAPK14 NFATC1 LYN SPI1 TNFSF11 TNFRSF11B MAPK8 SYK TRAF2 SRC RAC1 CHUK FHL2 RELA TNFRSF11A MAPK9 MAP3K7 PAPSS2 RELB GAB2 NFKBIA MAP3K7IP1 TRAF3 TRAF6 DOPAMINE METABOLISM%WIKIPATHWAYS_20260410%WP2436%HOMO SAPIENS Dopamine metabolism NQO1 PRKACG DDC TH PPP2CA MAOA TYR HEL-S-44 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation RHBDD2 TMEM120A SSC4D DAPK2 STYXL1 POR HEL163 PTPMT1 RAF1 EPB41L3 KIF1C SFN ZP3 ZP2 YWHAG LMNA HEL-S-102 MDH2 TMEM120B SRRM3 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260410%WP5234%HOMO SAPIENS Bardet Biedl syndrome TMEM67 RAB23 PDE6D NPHP3 EVC2 BBS2 NEK8 BBS1 USP9X PCARE SCLT1 DCDC2 FUZ BBIP1 INPP5E TTC8 MKS1 IFT27 CEP41 TRIM32 CLUAP1 OCRL SMO SUFU PTCH1 KIF7 GLI3 DYNC2I2 INVS TRAF3IP1 IFT172 CEP164 PKD1 IFT52 FLCN ZIC2 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 CEP290 SCAPER BBS4 DYNC2H1 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 IFT81 GPR161 MAK TMEM216 EFHC1 WDPCP EFHC2 CNGB1 SDCCAG8 CEP104 ARL6 ARL3 DYNLT2B CRX PKD1L1 DYNC2LI1 PKHD1 IFT74 ARL13B MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer BBC3 PTEN CHEK2 ATM PMAIP1 CASP9 CASP8 CASP3 EI24 SIAH1 SHISA5 TNFRSF10B DDB2 CYS1 BAX TP53AIP1 SESN3 ZMAT3 MDM2 PERP APAF1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260410%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT2 NOS2 CARM1 PRMT3 PRMT1 PRMT6 HEL-S-277 PRMT7 VISUAL CYCLE%WIKIPATHWAYS_20260410%WP5534%HOMO SAPIENS Visual cycle RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW RDH12 RDH10 OPN1LW RBP3 RDH11 RBP1 RHO RDH5 LRAT NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260410%WP4255%HOMO SAPIENS Non small cell lung cancer CDK6 BAD RASSF1 PLCG2 CDK4 STAT3 FOXO3A PLCG1 ALK PIK3CA RB1 PDPK1 E2F2 E2F3 CCND1 CASP9 AKT3 CASP8 KIF5A HEL-S-61 CASP3 CRABP2 CRABP1 STK4 CDKN1A FHIT HGF TGFA RET ERBB2 MET EGFR GADD45B GADD45A GADD45G CYCS ARAF BAK1 NRAS MAPK1 HRAS CDKN2A MAPK3 RXRB EGF RXRA RXRG BAX MAP2K1 MAP2K2 BRAF GRB2 KRAS EML4 SOS1 RAF1 SOS2 JAK3 PIK3CD PRKCB POLK PRKCA DDB2 RARB STAT5B GASTRIN SIGNALING%WIKIPATHWAYS_20260410%WP4659%HOMO SAPIENS Gastrin signaling MYC BAD FOXO3A PLCG1 PIK3R3 PIK3CA CDKN1A CLDN1 KAT5 MEF2B SLC9A3 PRKD2 PRKD1 ARHGEF28 YES1 TCF4 BMP2 ELAVL1 SERPINB2 KIT RHOD EGFR RHOB CCKBR ATF2 GAS CD44 CXCL8 TFF2 HDC HDAC7 PTGS2 TJP1 FOXO1 IKBKB ANXA2 MEF2D MAPK1 FOS HRAS CDKN2A MAPK3 JUN MAP2K1 MAPK14 GRB2 KRAS SOS1 RAF1 LAMTOR3 IRS1 MEF2C RAC1 RPS6 CREB1 MMP7 CRK PIK3R2 PIK3R1 ROCK1 EIF4EBP1 CDC42 FYN ARHA SP1 STAT3 PTPN11 MTOR MAP3K11 RPS6KB1 ITGB1 BIRC5 BIRC2 BIRC3 PPARG GSK3B CCND1 ARRB2 MAPK8 PAK1 CASP3 PRKCQ CHUK NFKBIA BCL2L1 NFKB1 KLF4 IL2 CDKN1B PRKCH PRKCE PRKCA CTNNB1 SRC PXN RELA MAPK9 EGR1 VEGFA CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260410%WP2029%HOMO SAPIENS Cell differentiation index STAT3 HDAC5 LEFTY1 TLX3 TLX2 TLX1 LEFTY2 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260410%WP5130%HOMO SAPIENS Th17 cell differentiation pathway SMAD2 SOCS3 STAT1 STAT3 MTOR PLCG1 TGFB1 NFATC1 FOXP3 HLA-DMA MAPK8 IL2RA PRKCQ LAT TGFBR1 IL23A NFKBIA AHR IKBKB IF2B1 IL23R MAPK1 RORC FOS CD3G IL27 CD3E CD3D IL6 IL-21 RXRA IL27RA PPP3CA JUN CRY1 NFIL3 TBX21 IL21R NFKB1 IL6R NR1D1 MAPK14 RORA PER1 GATA3 IL17F IL17A IL2 IL4 IRF4 RARA IFNGR1 RUNX1 JAK1 IL1B HIF1A IFNG TYK2 ZAP70 LCK MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD3B2 SULT1A1 UGT1A1 HSD17B2 HSD3B1 HSD17B3 SRD5A2 CYP17A1 CYP11A1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260410%WP15%HOMO SAPIENS Selenium micronutrient network PLG TXN SELENOK SELENOI SELENOH PRDX3 PRDX5 CBS ALOX5 INS XDH ALOX15B HEL-S-78p INSR HEL-S-2a CTH HEL-S-44 ALB ALOX5AP SAA1 SAA2 MSRB1 SELS NFKB2 TNF TXNRD3 TXNRD2 SCARB1 MPO APOB PTGS2 LDLR ABCA1 CCL2 FLAD1 IL6 CRP PTGS1 NFKB1 SERPINA3 HEL-S-97n HBB MTR PLAT KYNU SEPHS2 FGA GPX2 GPX1 GPX4 GPX3 GPX6 HEL-S-302 DIO1 HBA2 KMO IL1B HEL-75 F2 SELENOO RELA F7 IFNG SELENON SELENOM SELENOP SELENOW SELENOV SELENOT SAA4 SELENOF DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260410%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260410%WP5294%HOMO SAPIENS Sildenafil treatment PARK2 PDE4D GSK3B NRF1 PPARGC1A AKT3 NOS2 GUCY1A2 GUCY1B1 PDE4B ZNF746 PDE4A HEL-S-162eP TFAM PDE5A PRKG1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260410%WP2253%HOMO SAPIENS Pilocytic astrocytoma PTPN11 GRB2 HRAS KRAS SOS1 RAF1 BRAF NRAS NF1 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260410%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport ABCC3 HSD3B7 ABCC2 ABCB1 ABCD3 ATP8B1 ABCB4 SLC10A2 SLC51A BAAT SLC51B ABCB11 CYP7B1 CYP8B1 CYP27A1 SLCO1B1 AMACR FABP6 SLC27A5 HSD17B4 CYP7A1 SLC27A2 AKR1C4 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260410%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK SELENOI SELENOH POU2F1 CTH SP1 FOS FABP1 MSRB1 SELS JUN NFE2L2 NFKB1 CREM TXNRD3 SEPHS2 TXNRD2 GPX2 GPX1 GPX4 GPX3 RPL30 GPX6 DIO1 HEL-S-134P SEPHS1 PSTK RELA EEFSEC SELENOO TRNAU1AP SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SP3 SELENOW SELENOV SELENOT SELENOF UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260410%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP2 MMP9 PTEN SMAD2 ALOX5 CDC2 PCNA ARHA STAT3 PTPN11 DDIT3 TGFB1 GSK3B NCF2 TNF NCF4 CASP9 MAPK8 CYBB CYBA CASP3 CHUK GSK3A IRF3 NPPB AIFM2 NPPA UTS2R TRPC4 COL2A1 EGFR ESPL1 UTS2 EP300 PLN BCL2 HSPA2 NOX4 HDAC5 ABCA1 IKBKB HMOX1 MAPK1 COL1A1 MAPK3 COL3A1 IL6 CCNE1 BAX CDK2 NFKB1 CREBBP MAPK14 ACTA2 AGTR1 CTNNB1 VCAM1 IL1B RELA MAPK9 CAMK2A NCF1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C9 CYP2C8 CYP2B6 CYP2C19 CYP2C18 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260410%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CHEK2 BARD1 PLK1 CDC2 PCNA MSH2 SP1 FOXM1 PRKDC PML RAD51 WRN XRCC5 BCL6 PARP1 BRCA2 CHEK1 RPA1 HUS1 H2AX IKBKG RAD1 DCLRE1A TOPBP1 SMARCAL1 FEN1 ATRIP UBE2D3 CEP164 ATR HERC2 RAD9A TRIM28 UIMC1 SMARCC2 RMI1 TOP3A RECQL FANCD2 EEF1E1 CDK2 MCPH1 MDM2 MCM2 ABRAXAS1 USP1 XPA MDC1 RNF8 BRCC3 RAD50 PPM1D RECQL4 BRIP1 MRE11A CDC45 ATM BRCA1 RBBP8 NBN CLSPN TP53BP1 SMC1A POLN SHFM1 FANCA PALB2 CLK2 RAD52 RFWD3 TDP1 RAD17 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 GLS2 ARG1 ASL NAGS ASS1 SLC25A13 OTC FOCAL ADHESION%WIKIPATHWAYS_20260410%WP306%HOMO SAPIENS Focal adhesion PPP1CC TNR MYL11 ACTN1 PTEN MYL5 MYL7 TLN2 TLN1 BLK TXK BAD MYL12A VTN CHAD MYL10 VASP SRMS CAV3 KDR TNK1 PARVA PARVB COL1A2 PIP5K1C PARVG COL5A3 SHC4 COL5A2 SHC2 ITGB5 SHC3 RASGRF1 PIK3R3 ARHGAP5 ITGB8 ITGB7 ITGB6 VWF PDGFD EMP2 PIK3CA PDGFC HEL-S-28 ITGA7 IGF1R PPP1R12B CCND3 PPP1R12C DOCK1 THBS4 PDPK1 THBS3 RELN IGF1 FLNA FLNB STYK1 ZYX MYL12B VAV3 VAV2 ROCK2 EGFR PAK6 MAPK1 PAK4 HRAS MAPK3 VEGFB VEGFC THBS1 VEGFD JUN MAP2K1 c-fgr BRAF MYLK HEL-S-80p MAPK10 IBSP ACTN4 GRB2 SOS1 RAF1 MYL2 ITGB3 ITGA2B PDGFRA COL4A2 COL4A1 PIK3CD CRKL COL4A4 COL4A6 RAC1 VAV1 CAV2 TNK2 RAPGEF1 PTK6 CRK PIK3R2 PIK3R1 ROCK1 XB RAP1A CDC42 FYN ARHA ITGB1 FLT1 ITGB4 LAMC2 LAMC1 BIRC2 BIRC3 GSK3B PDGFA ACTG1 CCND1 ITGAV AKT3 ITGA4 MAPK8 ITGA2 PAK1 ITGA1 PS1TP5BP1 HGF ITGA6 LAMA5 ERBB2 COL2A1 MET LAMA1 LAMA4 BCL2 LAMA3 CCND2 RAC3 THBS2 COL1A1 LAMB3 EGF LAMB2 LAMB1 SPP1 PRKCB PRKCA CTNNB1 SRC PXN MAPK9 MYLK2 TNC HEL114 ARHGAP35 MYLK3 MYLK4 VEGFA COMP NRF2 ARE REGULATION%WIKIPATHWAYS_20260410%WP4357%HOMO SAPIENS NRF2 ARE regulation NQO1 MAF KEAP1 GSK3B RBX1 INSR AIMP2 GCLC HMOX1 FYN MAPK8 PGAM5 GCLM EPHB2 PRKCA SRC CEBPB NFE2L2 YES1 SLC7A11 PIK3CA HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma TNFSF6 MYC CD44 CXCL8 PTGS2 NOS2 STAT3 PTPN11 MAPK3 IL6 JUN BCL2L1 NFKB1 IL6R MAPK14 BIRC5 TGFB1 GRB2 BIRC3 BRCA1 SOS1 E2F2 CCND1 CASP9 COL4A2 MAPK8 CXCR1 FRZB RRM2 CASP3 RAC1 MYOF JAK1 HNF1A HIF1A SMAD4 HEL-117 CDKN1A LEF1 TGFBR1 VAV2 VEGFA PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260410%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYC NCK1 CBL HEL-S-44 ARHA PLCG1 GSK3B MAPK8 PAK1 NEF3 CDKN1A TMSB4X NEFL AXIN1 NEFH TGFA ACTR3 ACTR2 DAAM1 PPP2CA PFN4 PFN1 ACTA1 PFN3 APC PFN2 ERBB2 ERBB4 ROCK2 EGFR CAMK1 FZD10 MAPK1 WNT16 MAP2K4 JUN MAP2K1 MYLK GRB2 MYL1 SOS1 RAF1 CDKN1B DVL1 FZD4 GPX1 FZD1 CTNNB1 SRC FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy DGAT1 DGAT2 GRB2 CAVIN1 BSCL2 HMFN0839 INS IRS1 FYN HIF1A ITGB4 LPIN1 LPIN2 LPIN3 PIK3CA AXON GUIDANCE%WIKIPATHWAYS_20260410%WP5289%HOMO SAPIENS Axon guidance ROCK1 EFNA1 NCK1 PRKCZ CDC42 CXCL12 FYN PARD3 ITGB1 EPHA2 HEL-S-28 PDPK1 GSK3B SHH GNAI1 MYL12B PTCH1 RHOD MET ROBO2 NRP1 SEMA5B ROBO3 BMPR2 ROBO1 DPYSL5 BOC EPHB1 RRAS gdf7 TRPC1 MAPK1 UNC5D HRAS RGMA SEMA7A SEMA3A NTN3 EFNB1 PARD6A ABLIM3 SLIT1 PLXNA1 SLIT3 SLIT2 LRIG2 SRGAP2 NTNG2 L1CAM CDK5 FES NGL1 RAF1 PRKCA ARHGEF12 RAC1 SRC DCC FZD3 CXCR4 WNT4 RYK HEL-S-15 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260410%WP391%HOMO SAPIENS Mitochondrial gene expression ESRRA MYEF2 MTERF3 TFB2M NRF1 PPARGC1A GABPB1 TFB1M PPARGC1B POLRMT PPRC1 CAMK4 MTERF1 SP1 GABPA HCFC1 PPP3CA CREB1 TFAM INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260410%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy RPS6KA3 ARAF MAPK1 MTOR MAPK3 MAP2K1 ACSS1 MAP2K2 BRAF RPS6KA1 DLD RAF1 PPARGC1A HEL-S-30 GPX4 HEL-S-133P PFKFB2 RPTOR RPS6KA2 GLS LDHB NAMPT MLST8 DLAT SLC16A3 CPT1A HEL-75 PKLR HEL-S-304 PDHA1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260410%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H3C15 PCGF1 MACROH2A2 EZH2 RNF2 H2AX EED MAPK1 SUZ12 BCL6 MAPK3 H2AZ1 H2AZ2 H3C8 H3F3B H2AB3 H2AB1 MACROH2A1 H2AJ BCOR CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260410%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer ERBB2 PIK3R4 EGFR CDK6 PIK3R2 PIK3C2G PIK3R1 PIK3C2A INS PIK3C2B NRAS CDK4 MAPK1 HRAS MTOR MAPK3 CCNE1 PIK3R3 CDK2 PIK3R5 PIK3CA IGF1R KRAS RAF1 CDKN1B CCND1 IRS1 AKT3 PIK3CD RPTOR CDKN1A STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis HSD3B2 HSD3B1 SRD5A2 CYP17A1 CYP21A2 AKR1C1 CYP11A1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260410%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD PON1 LIPA HEL126 CES2 CES1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260410%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 MYD88 IRF9 IFNAR1 TMPRSS2 ACE2 IFIH1 EIF2AK2 MAVS OAS1 OAS2 TREML4 RIGI STAT1 STAT2 TLR3 TBK1 IKBKE JAK1 IFNAR2 IRAK4 TYK2 TLR9 IRF3 TRAF3 TLR7 TRAF6 IRF7 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260410%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer STAT3 MAPK1 EGFR JAK1 MAPK3 HEROIN METABOLISM%WIKIPATHWAYS_20260410%WP2645%HOMO SAPIENS Heroin metabolism CES2 CES1 BCHE CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260410%WP4562%HOMO SAPIENS Canonical NF kB pathway CHUK REL RELA NFKBIA IKBKB IKBKG NFKB1 NFKBIE ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260410%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260410%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides DGAT1 CERK SGMS1 SPTLC1 SPHK1 SGMS2 UGCG B4GALNT1 tmp_locus_29 KDSR CERS5 UGT8 CERS6 B3GNT5 A4GALT A3GALT2 CERS1 CERS2 CERS3 B4GALT1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation BMP2 DKFZp781O1323 FOXO1 LEFTY2 CTNNB1 BCL2L11 SMAD1 DCN WNT4 DKK1 SST SFRP1 SMAD9 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CBS MTR MAT1A pcap HEL-S-61p ADK CTH HEL-S-182mP CDO1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260410%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA HSD17B4 ACOX1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 PEMT CHPT1 SGPL1 CEPT1 PISD AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260410%WP5526%HOMO SAPIENS Age related macular degeneration PRKAA2 PMAIP1 PPARGC1A HEL-S-32 PARP2 PRKAG1 PRKAG2 RPTOR PRKAA1 PRKAG3 MLST8 MTOR PRKAB2 SIRT1 RPS6KB1 MAPK3 PRKAB1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway ALOX5AP B3GNT5 NFKB2 PDE4B BIRC2 BIRC3 CDKN1C TNFAIP3 THBD EPB41L4B ARL5B RGS2 DNER ENC1 ANKRD1 TNS4 SRGN IL11 FGFBP1 EDN2 TSC22D3 POU5F1 NAV3 TGFBR3 ADGRF4 CDC42EP3 SCNN1A PMP2 ANGPTL4 MFGE8 SLC26A2 ABHD2 GADD45B NR1I3 AMIGO2 BHLHB2 PRRG4 FGD4 PTGS2 GPR153 SERTAD2 STOM CCL2 MGAM PPP1R14C CAVIN2 PTGES3 PLK2 NR1i2 DNAJC15 KTN1 ACKR3 ZIC2 S100P SNAI2 SPRY1 RXRA CPEB4 JUN CCL20 NR3C1 SLC19A2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260410%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 MAPKAPK2 RAP1A RPS6KA5 MAPK1 MAPK3 GNAS HTR4 HTR6 EGR1 MAP2K1 HTR7 MAP2K2 BRAF CREB1 ATF1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260410%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome PCNA ITCH SIRT6 SMAD1 SMAD9 DKFZp781O1323 DLD MAPK8 BMP2 ATF2 BCL2 SIRT1 SMARCC2 RIF1 OGDHL EIF4ENIF1 FAM170B ELOA CEFIP VSTM4 NEO1 MEN1 SLC18A3 NOG RGMB BAZ1B WDFY4 PARG LRRC18 CUL5 DDX21 ARHGAP22 HSF1 HSF4 ChAT SF3B1 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 GDF5 MYO1C JUND MYBBP1A UVSSA NLRP3 ERCC5 BMPR1A TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260410%WP5300%HOMO SAPIENS TROP2 regulatory signaling ACVRL1 PSEN2 TACSTD2 EGFR PTEN ABCC1 CLDN7 PIK3R1 BCL2 PECAM1 TLN1 CHEK1 STAT1 CDK4 PAK4 HEL113 CDKN2A CCNE1 BAX ITGB1 JUN CDK2 NFKB1 IGF1R RB1 MDK IGF2 IGF1 CDKN1B CCND1 PRKCA CTNNB1 SRC RAC1 IGF2R NOTCH1 CLDN1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260410%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3R2 PIK3C2G PIK3R1 PIK3C2A PIK3C2B PIK3R3 PIK3R5 PIK3CD PIK3CA GDNF SIGNALING%WIKIPATHWAYS_20260410%WP5143%HOMO SAPIENS GDNF signaling IRINOTECAN PATHWAY%WIKIPATHWAYS_20260410%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 ABCC1 UGT1A1 UGT1A10 UGT1A9 CES2 ABCG2 CES1 BCHE SLCO1B1 CYP3A4 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome HES5 SMAD2 PRKCZ PANK4 IFIH1 INTS11 INTS13 RBX1 ARF6 VTN INTS14 INTS10 GDE1 TMEM52 GRIK2 NOC2L IFIT1 METTL14 TRIM25 SDF4 PLEKHN1 CCNL2 TNFRSF4 SAMD11 MUSK TNFRSF18 HEL-S-72p SSU72 TRAF5 PEX2 COMMD1 ATAD3A TGFB1 ATAD3C DKK3 GLTPD1 ACAP3 RER1 SCNN1D MMP23B C1QTNF12 MRPL20 PEX5 MXRA8 VWA1 AURKAIP1 TNLG2B TNLG2A CALML6 PERM1 KLHL17 TRAF2 MEPCE LRP4 UBE2J2 PARD6B PHKG2 SMAD4 BTLA GNB1 TNFRSF14 PUSL1 TAS1R3 NADK HES4 OR4F5 OR4F3 CDK11A CFAP74 ELAVL1 CD160 MIB2 ISG15 B3GALT6 PEX10 PEX12 SKI RNF223 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 INTS4 PLCH2 INTS9 AGRN SLC35E2B C1orf159 MCM2 DVL1 VEGFA OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260410%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol NR1i2 RORC IL25 INSIG1 CYP46A1 DBP THEM5 SULT2A1 CYP7A1 ACOT9 ACOT8 ACOT7 NR1H2 ACOT11 SLC27A2 ACOT12 ACOT13 EPHX2 SULT2B1 NR3A2 IL17F HSD3B7 CH25H IL17A GPR183 IL17D ACOT6 IL17C LBP IL17B ACOT4 BAAT CYP7B1 CYP8B1 CYP27A1 AMACR SLC27A5 EBP HSD11B1 HSD11B2 DHCR7 AKR1C4 CYP3A4 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260410%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction RPS6KA1 ACE2 TOMM70 MITA NLRX1 TNF ACAD9 MAVS IL18 TERF2 NDUFAF2 TERF2IP REN NDUFAF1 SIRT6 IL6 NFKB1 TRAF3 ECSIT TRAF6 NLRP3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260410%WP5598%HOMO SAPIENS Sodium channel in epilepsy SCN10A SCNM1 SCN8A SCN4A SCN2A SCN4B SCN2B RNF121 FGF14 FYN FGF13 FGF12 NEDD4 CALM1 GSK3B TNF PTPRN PSEN1 SCN11A PDCD10 SCN9A SCN7A SCN5A SCN3B SCN3A SCN1B CAMK2A SCN1A PRRT2 MAPK8IP2 BACE1 WEE1 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260410%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAMK2G IFI27L2 PRKCZ IFI44L CAMP MED1 OAS2 RSAD2 DEFB4B CYP27B1 PLCG2 NR1i1 STAT1 STAT2 CD40LG SP1 CYP24A1 PLCE1 NFKB2 PLCB4 PLCB1 NOD2 PLCB2 TNF MAPK8 PRKCQ RELB TLR8 SP3 MAPK13 TLR4 ISG15 CXCL8 MAPK7 IFNA2 IKBKB CCL2 NRAS MAPK1 HRAS MAPK3 RXRB IL6 RXRA RXRG JUN NFKB1 TNFRSF1A MAPK14 MAPK12 PLCB3 CD40 KRAS PRKCH MAPK11 PRKCB PRKCE PRKCA IFNGR1 IFNGR2 JAK1 IFNAR2 IFNG MAPK9 TYK2 CAMK2D CAMK2A VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260410%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins NQO1 VKORC1 UBIAD1 F9 PROC F10 F2 F7 GGCX PROS1 PROZ AIFM2 MELANOMA%WIKIPATHWAYS_20260410%WP4685%HOMO SAPIENS Melanoma CDK6 PTEN PIK3R2 PIK3R1 BAD ARHA CDK4 KDR PTPN11 SHC2 GRM3 PIK3R3 PREX2 EXOC7 PDE5A PIK3CA RB1 E2F2 E2F3 CCND1 AKT3 PAK1 CALML6 CALML3 CALML4 CDKN1A KIT ERBB4 RHOB GADD45B GADD45A GADD45G ARAF BAK1 NRAS NF1 MAPK1 HRAS CDKN2A MAPK3 BAX MAP2K1 MDM2 MAP2K2 BRAF CALM1 GRB2 KRAS SOS1 RAF1 SOS2 PIK3CD POLK RAC1 DDB2 HEL114 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDK6 PTEN MAPKAP1 PIK3R2 PIK3R1 EIF4EBP1 EIF4E NOTCH2 CDK4 PRKAA1 MTOR NFKB2 REL FGFR1 PIK3R5 MAML1 STK11 TERT SESN1 PIK3CA SESN2 TP63 IGF1R DDIT4 BIRC2 NUMB IRF6 CSMD3 RB1 PDPK1 FKBP1A FAT1 LTBR CCND1 AKT3 CASP8 SMAD4 CDKN1A FADD TGFBR2 TRAF3 ERBB2 PRKAA2 EGFR FGFR3 KEAP1 NRAS TSC1 HRAS CDKN2A RHEB RPS6KB2 NFE2L2 NFKB1 KRAS TSC2 RPTOR CTNNB1 MLST8 AJUBA NOTCH1 RELA RPS6 RICTOR VEGFA PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260410%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH P38 MAPK SIGNALING%WIKIPATHWAYS_20260410%WP400%HOMO SAPIENS p38 MAPK signaling MYC MAPKAPK2 ATF2 SMIM40 CDC42 MAP3K5 MEF2D STAT1 HRAS MAP2K6 MAP2K4 RASGRF1 DDIT3 MAP3K1 MAPK14 RIPK1 GRB2 HMGN1 TRADD MAPKAPK5 RPS6KA5 TRAF2 RAC1 MAX MAP3K7 HEL-S-102 TGFBR1 CREB1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260410%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling PPP1CC CAMK2G SMAD2 GRIK2 PLCB4 PLCB1 PLCB2 SLC1A4 IGF1 ADCY3 IL10 ADCY1 ADCY8 MAPK1 FOS MAPK3 IL6 FGF2 HEL-S-80p CALM1 PLCB3 IRS1 CAMK4 GLS IFNGR1 DLAT IFNGR2 JAK1 IL1B HEL-S-15 CREB1 BDNF IL13RA1 SOCS3 INSR STAT1 STAT3 NFKB2 TRAF5 SLC7A10 TGFB1 IL1R1 DLD TNF CNTF PIG59 PSPH SLC38A1 IL1R2 ARC GRIA2 NGF SHMT1 SLC1A1 IL12B SLC1A2 SMAD4 IL12A SLC1A3 NELF SLC38A3 SLC38A5 GRIA3 TGFBR1 GRIA4 TGFBR2 LIF GRIN2B TGFBR3 GFAP GRIN3B DAO IL1A GRIN3A SLC6A9 GRIK5 GRIK3 BCL2 GRIK1 SLC2A3 GRM2 GRM4 GRM8 PHGDH TNFRSF1B LTA HEL-S-51e CAMKK1 CAMKK2 IL13 SRR LRRC8C LRRC8D SLC17A6 SLC17A7 DISC1 LRRC8E IL10RB IL10RA GRIN1 PSAT1 NFKB1 IL6R TNFRSF1A IL4 PRKCB PRKCA IL6ST GLS2 IFNG CAMK2D PDHA1 CAMK2A CAFFEINE IN NEURONS%WIKIPATHWAYS_20260410%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma TGFB1 EGLN2 PRCC TFEB VHL SFPQ BIRC7 CTSK COL21A1 EP300 SETD2 RBX1 DVL2 ELOC HIF1A CDKN1A FH TGFA EGLN1 CREBBP VEGFA EGLN3 CADM2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260410%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons CDK5 CHRNB2 CHRNA3 KCNK9 CHRNA5 CHRNA6 PPP1R1B DRD2 DRD3 GNAI1 SLC18A2 DRD4 KCNK3 GNG2 GNB1 DDC TH GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260410%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione C7orf24 OPLAH GCLC HEL-S-64p PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260410%WP2878%HOMO SAPIENS PPAR alpha pathway APOA2 APOC3 SLC27A1 APOA5 MYC DBI UGT1A9 EHHADH CDC2 CCND1 CYP8B1 CDK4 CYP4A11 FABP1 NR1H3 KLK15 NR1C1 CPT2 CPT1A ACADM RXRA CYP7A1 PLTP STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260410%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 CGAS MITA NLRX1 IKBKB IKBKG NFKBIE TBK1 IKBKE CHUK IL1B IFNB1 GSDMD RELA REL F3 FCGR2A NFKBIA IRF3 NFKB1 NLRP3 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260410%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G4C PLA2G3 PLA2G5 PLA2G6 PLA2G7 SLCO2A1 PLA2G10 ALOX5 PTGS2 HRAS CDKN1A PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G1B PLA2G4E MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 CCND3 MYC ATM CDKN1A CCNE1 CDKN1B CCND1 H2AX RAD52 CREB1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260410%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways HES5 TCF3 CHRM2 HEL2 VIPR2 AQP4 SOX2 C4A PKNOX1 CHRNB4 TSPYL1 POU3F2 CAV3 RUNX3 PRKAR1B PRKAR1A LMX1B TPH2 DLX2 TPH1 ADCYAP1R1 CHRNA7 C4B_2 NEUROD1 DEAF1 SPTBN1 NKX2-2 POU2F2 G6PC1 PHOX2B PHOX2A TF FEV PAH CC2D1A TP73 SNAP25 RYR2 ECE1 CTCF GNB3 YBX1 HTR2A FREP1 SNTA1 EN1 TACR1 SSTR2 YWHAZ HADHB NOS1AP AVP SLC25A4 VAMP2 IL10 ASCL1 SLC9A3 HDAC9 HSPD1 KCNJ8 NFYA REST RET GPD1L 5HT1A YWHAQ EP300 CXCL8 TLX3 MAP2 IL6 JUN CREBBP HEL-S-125m MYB GJA1 MEF2C IL1B CPT1A HEL-S-87p SCN5A SCN3B GATA2 HEL-S-162eP CREB1 NR1A2 BDNF SCN4B SP1 GCK NFKB2 NKX3-1 CEBPB SST IL1RN CREM FOXM1 HDAC1 PPARGC1A TNF PPARGC1B HEL-S-1 NGF CASP3 SLC1A3 DDC TH SP3 POU5F1 MAOA IL1A BHLHB2 YWHAG IL13 NTRK2 GRIN1 NFKB1 IL6R RORA NR3A2 GATA3 NR3C1 CHRNB2 PBX1 CTNNB1 ChAT HIF1A ACADM EGR1 VEGFA HES1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260410%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP2R1 AGTR2 ACE2 AGTR1 CYP27B1 REN 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260410%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways EPHX2 NPC1 ACOT6 ACOT4 BAAT CYP27A1 AMACR SLC27A5 EBP DBP HSD11B1 THEM5 HSD11B2 NPC2 ACOT9 CYP7A1 ACOT8 DHCR7 ACOT7 ACOT11 SLC27A2 ACOT12 ACOT13 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260410%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death VMP1 SH3GLB1 ATG3 BCL2 UVRAG ATG9B ATG10 AMBRA1 INS ATG14 TSC2 ATG12 INSR MAP1LC3A CHAF1A ATG16L1 TSC1 ULK2 ULK1 ATG5 MIRNA BIOGENESIS%WIKIPATHWAYS_20260410%WP2338%HOMO SAPIENS miRNA biogenesis DGCR8 DROSHA DICER1 TARBP2 RAN XPO5 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260410%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling HES5 CDK6 CSNK1A1L ZMPSTE24 FNTA ICMT DICER1 TARBP2 SLC2A4 CEBPA TOR1AIP1 EMD HMGA2 CEBPB RUNX2 AGO2 CEBPD PPARG GSK3B SPP1 CCND1 CTNNB1 WNT10B TCF7L2 LMNA TCF7L1 LEF1 CSNK1A1 AXIN1 HES1 APC DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260410%WP5173%HOMO SAPIENS Disorders of galactose metabolism PYGL GYS1 GYG1 GYS2 HEL-S-19 SLC2A2 AKR1B1 SLC5A1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260410%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis TNFSF6 BBC3 MCL1 BCL2 BAD TNF CASP9 MAPK11 CASP8 BCL2L11 CASP3 FADD BAX BCL2L1 APAF1 MAPK14 MAPK13 MAPK12 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260410%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption RAB5A ADCY6 AQP4 PRKACG ADCY9 HEL-S-47e DYNC2H1 DCTN6 RAB5C DCTN5 RAB5B DCTN1 DCTN4 ARHGDIG HEL-S-77 AQP2 AQP3 ADCY3 CREB3L3 CREB3L4 CREB3L2 STX4A DYNC1I1 DYNC1H1 AVPR2 DYNLL2 RAB11A ARHGDIB RAB11B CREB3 DYNC1LI1 AVP DYNC1LI2 GNAS DNCL1 VAMP2 CREB5 DYNC2LI1 CREB1 IL7 SIGNALING%WIKIPATHWAYS_20260410%WP205%HOMO SAPIENS IL7 signaling PIK3R2 PIK3R1 IL2RG GSK3B BAD IL7 IL7R JAK3 FYN STAT1 STAT3 MAPK1 JAK1 MAPK3 PTK2B MAP2K1 STAT5B MAP2K2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260410%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DGCR8 DROSHA DICER1 ERI1 AGO2 XPO5 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260410%WP183%HOMO SAPIENS Proteasome degradation UBA7 HEL-S-91n PSMD13 UBE2D2 RPN1 UBE2D1 PSMB10 PSMB6 PSMD9 PSMD6 PSMD7 PSMB2 PSMD4 H2AX UBB PSMD5 PSMB3 PSMD2 UBE2D3 PSMD3 UBC PSMD1 HIST1H2AB NEDD4 UBE2B HLA-B HLA-C HLA-A HLA-F PSMB8 HLA-E HEL-S-283 PSMC6 PSMA4 PSMC4 PSMA2 PSMC1 PSME2 HLA-G HEL-117 IFNG H2AZ1 PSMD10 PSMD12 PSMD11 HEL-S-276 RPN2 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 AADAT KMO GOT2 KYAT3 IFNG KYAT1 IDO2 KYNU TNF IDO1 SLEEP REGULATION%WIKIPATHWAYS_20260410%WP3591%HOMO SAPIENS Sleep regulation UTS2R UTS2 FOS IL6 STAR ADORA2A CHRNB2 NLGN1 OXTR DRD2 NPY2R DRD3 IL18 OXT HTR2A NPAS2 NPS CACNA1I HEL-S-2 DRD1 PTGDR DLAT MRGPRX2 BTBD9 HCRTR2 HCRTR1 PER3 MTNR1B GHRH CRH TH GHRL SLC29A1 ADA BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260410%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders RRM2B DPYS RRM2 DPYD HEL74 UMPS HEL-S-29 TYMP TYMS DHODH NT5C3A RRM1 SERINE METABOLISM%WIKIPATHWAYS_20260410%WP4688%HOMO SAPIENS Serine metabolism SRR SHMT1 TYMS DHFR PSAT1 PHGDH HEL-S-51e PSPH INSULIN SIGNALING%WIKIPATHWAYS_20260410%WP481%HOMO SAPIENS Insulin signaling RPS6KA6 PTEN PIK3C2G PIK3C2A RPS6KA3 MAP3K8 PRKAA1 FOXO3A SHC2 SHC3 PIK3R3 INPP4A PIK3CA IGF1R RPS6KA1 PDPK1 SNAP25 HEL-S-61 MAP4K1 VAMP2 MAP4K2 SNAP23 MINK1 MAPK13 GYS1 FOXO1 IKBKB CAP1 MAP3K5 MAP4K3 TSC1 MAPK1 FOS HRAS MAP2K6 SLC2A4 MAPK3 MAP3K2 MAP2K3 RHEB MAP2K4 JUN MAP2K1 GYS2 MAP3K1 MAP2K2 MAPK14 MAPK12 MAPK10 GYG1 GRB2 SOS1 RAF1 MAP3K6 SOS2 MAP3K12 TSC2 IRS1 INPPL1 CBLC PIK3CD STX4A RPS6KA2 RPS6KA4 GRB10 RPS6KA5 PRKCI RAC1 STXBP1 PFKM RAPGEF1 MAP2K5 CRK PIK3R4 PIK3R2 PIK3R1 CBL SOCS3 PRKCZ SOCS1 EIF4EBP1 ARF6 INSR MAP3K10 EIF4E MAPK4 PTPN11 MTOR MAP3K11 RPS6KB1 HEL-S-31 MAP3K14 GSK3B MAPK8 PRKCQ MAP3K7 GSK3A PRKAA2 LIPE MAPK7 IRS4 GRB14 ENPP1 TRIB3 STXBP3 STXBP4 RRAD PPP1R3A KIF3A XBP1 RAB4A EHD1 EHD2 MAP3K13 ARF1 PTPRF FLOT1 FLOT2 RPS6KB2 TBC1D4 SGK1 SGK2 SNX26 MAPK6 SH2B2 PTPN1 HEL-S-42 PFKL PRKCH MAPK11 PRKCB PRKCA MAPK9 EGR1 MYO1C AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260410%WP699%HOMO SAPIENS Aflatoxin B1 metabolism GSTM1 EPHX1 HEL-S-166mP CYP2A13 CYP3A4 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260410%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX HEL-S-298 HPGD TRPA1 ALOX5 EHHADH CYP4F2 ALOX15 ALOX15B CYP4A22 ALOX12 NR1C2 FPR2 TRPV1 LTC4S PTGR1 CYP4F12 CYP4A11 LTB4R KPG_011 NR1C1 ACOX3 ACOX1 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260410%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway FCN1 ACE2 COLEC11 C6 C7 HEL-S-62p C9 C5AR1 C3AR1 MASP2 C8A CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling ADAM10 PSEN2 RBPJ MFAP1 MFAP2 JAG2 NOTCH2 NOTCH3 RRAS PSEN1 DNER CHUK MAML3 NOTCH1 LEF1 DLL3 MAML1 DLL4 MAML2 HES1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260410%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMA5 LAMA1 PIK3R2 LAMA3 PIK3R1 EIF4EBP1 ARHA MAPK1 PTPN11 HRAS MTOR LAMB3 MAPK3 LAMB2 LAMB1 ITGB4 MAPK14 LAMC2 LAMC1 GRB2 SOS1 IRS1 PRKCA SRC RAC1 ITGA6 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260410%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair SUPT16H ATM H4C9 HIST1H4L NBN PRKDC SSRP1 TP53BP1 H1-1 RNF168 NASP SETD2 RAD51 XRCC5 MDC1 RNF8 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260410%WP3944%HOMO SAPIENS Serotonin and anxiety related events 5HT1A ARC FOS PLCD4 PPP3CA NLGN1 CRH PLEK CRHR1 HTR2A PRKCB MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260410%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 AGTR2 TMPRSS2 CGAS ACE2 MITA IFIH1 MAVS RIGI NDUFB9 PHB2 CTSL NFKB2 NFKB1 ECSIT AGTR1 TOMM70 TLR3 NLRX1 ACAD9 REN NDUFAF1 TBK1 IKBKE TICAM1 IRF3 TRAF3 TLR7 TRAF6 IRF7 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260410%WP4758%HOMO SAPIENS Nephrotic syndrome ZMPSTE24 SMARCAL1 COQ2 SCARB2 CD151 PTPRO PLCE1 CTLA4 GPC5 LMX1B APOL1 SYNPO YARS LAMB2 CUBN HEL-S-47e TRPC6 ALG1 COQ6 ITGB4 WDR73 ARHGAP24 PAX2 CD2AP EMP2 MYO1E INF2 NPHS1 ACTN4 NPHS2 MYH9 COQ8B E2F3 COL4A4 WT1 COL4A3 COL4A5 LMNA CYP11B2 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260410%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B PYCARD RELA TRAF3 NFKB1 NLRP3 SPINAL CORD INJURY%WIKIPATHWAYS_20260410%WP2431%HOMO SAPIENS Spinal cord injury PLA2G5 PLA2G6 MYC AQP4 CDC2 CDK4 FOXO3A NGFR XYLT1 RTN4 AQP1 ZFP36 ROS1 SEMA6A OMG MIF PDYN BCAN RTN4R KLK8 EFNB2 TACR1 CHST11 PLXNA2 TNFSF13 SELP APEX1 GDNF CSPG4 BTG2 NCAN CXCL2 CCR2 ANXA1 MMP12 VCAN GAP43 LTB AIF1 NTN1 CD47 ROCK2 EGFR ACAN RHOB TNLG7A E2F5 PLA2G2A CXCL8 LILRB3 CCNG1 PTGS2 NOS2 MAPK1 MBP FOS HEL113 RGMA MAPK3 IL6 PPP3CA CDK2 SLIT1 SLIT3 SLIT2 COL4A1 GJA1 RAC1 IL1B EPHA4 MMP9 BDNF CDC42 ARHA TGFB1 CXCL1 IL1R1 LEP PRB1 RB1 C1QB FKBP1A PRB2 TNF CCND1 CASP3 GFAP IL1A TLR4 COL2A1 GADD45A NOX4 CCL2 GRIN1 IL2 IL4 CDKN1B PRKCA SOX9 LTB4R ARG1 IFNG FCGR2A EGR1 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260410%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation PLG F2 F13A1 F13B FGA HEL-S-78p BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260410%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 SPHK2 SPHK1 SGPP2 SGPP1 SPTLC2 KDSR IL9 SIGNALING%WIKIPATHWAYS_20260410%WP22%HOMO SAPIENS IL9 signaling GRB2 PIK3R2 PIK3R1 IL2RG CDK9 IL9 JAK3 IL9R STAT1 STAT3 MAPK1 JAK1 MAPK3 MAP2K1 STAT5B MAP2K2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260410%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP2 MMP9 PIK3R4 BDNF PAK6 EPHB6 TRIO SORT1 EPHB1 EPHB4 ARHA EPHB3 NTRK2 PAK4 KIDINS220 STAT3 TWIST1 FOS F2RL2 TIAM1 ARF1 JUN PIK3R3 PIK3R5 PIK3CA NGFR AKT3 PIK3CD PAK1 EPHB2 RAC1 CDH11 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260410%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance PIK3R1 CD36 PRKCZ TNF INS EIF2AK2 IRS1 INSR ACSL1 MAPK8 PRKAG3 PDX1 MAFA SLC2A4 ERN1 RPS6KB1 TRAF1 PPP2CA TNFRSF1A INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260410%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition MTOR RPS6KB1 SLC2A4 RPS6 TBC1D4 IRS1 INSR MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260410%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness MAPK1 PRKCQ PLCG1 MAPK3 MFAP5 ITGB3 RYR3 JUN ITGAV CREB1 TNNC1 MTHFR DEFICIENCY%WIKIPATHWAYS_20260410%WP4288%HOMO SAPIENS MTHFR deficiency CHKA CYCS PEMT CHPT1 CASP9 CASP3 MARS1 ASMT GRIN1 EHMT1 HEL-S-61p CHDH DNMT3B ALDH7A1 TP53 NETWORK%WIKIPATHWAYS_20260410%WP1742%HOMO SAPIENS TP53 network OTX2 TP63 BOK BBC3 GADD45A MYC ATM BCL2 PMAIP1 TP73 CDKN2A CDKN1A BAX MDM2 SUMO1 TNFSF10 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260410%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A ATF4 SLC3A2 KEAP1 NFE2L2 SLC7A11 SLC7A5 BASE EXCISION REPAIR%WIKIPATHWAYS_20260410%WP4752%HOMO SAPIENS Base excision repair PCNA FEN1 APTX HMGB1 MPG OGG1 PNKP UNG POLE4 POLD3 POLD4 NTHL1 TDG POLD2 PARP2 POLE MUTYH POLG MBD4 TDP1 PARP3 RFC3 RFC4 PARP4 POLL LIG1 RFC1 APEX1 ADPRHL2 RFC2 SMUG1 NEIL3 NEIL2 POLG2 PARP1 POLE2 POLE3 NEIL1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260410%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators CXCL13 CXCL14 CXCL16 PPBP CXCL11 CXCL9 AREG CXCL3 CX3CL1 TNFSF13 IL10 CXCL2 XCL1 CCL11 TNLG7A CXCL8 CCL1 IL9 CCL7 IF2B1 CCL3 IL25 CCL19 IL27 CCL17 CCL15 IL6 CCL25 IL-21 CCL24 CCL22 CCL21 CCL20 CCL28 CCL27 PF4 CCL26 IL17F CSF3 IL17A CSF2 IL17D CSF1 IL17C EPO IL17B IL18 IF1AA9 CCL8 IL1B CCL4L2 CXCL17 IF2D MMP9 IF2G IL36A IL36B CCL3L3 IFNA13 EBI3 IFNA14 IL36RN IFNA16 TSLP IFNA17 IL36G IFNW1 IL1F10 IL3 CXCL12 CXCL6 IFNA10 IL5 IL24 IF1IB1 PF4V1 IL19 XCL2 IFNK CCL14 IFNA21 CCL13 CTF1 IFNL2 CCL18 IFNL3 CCL16 IL33 CCL23 IL1RN IL31 IFNA1 IL37 TGFB1 CXCL1 CXCL5 TNF CNTF MMP3 IL12B IFNB1 IL12A IL11 IL23A LIF IL1A IFNA4 IFNA7 IFNA6 IFNA2 CCL5 IFNA8 CCL4 LTA CCL2 IL15 IL13 NFKB1 IL2 IL4 IL7 SPP1 IFNG OSM VEGFA DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260410%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer SIK1 SIK2 GNAS HDAC7 HDAC5 DNAJB1 CREB1 CRTC2 SIK3 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260410%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA RPE PRPS1L1 DERA HEL-S-304 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260410%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MTR CUBN MMAA TCN2 CBLIF TCN1 MMACHC MMADHC CD320 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260410%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LPL APOA2 APOA4 SCARB1 APOE LDLR LIPC PLTP VLDLR DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260410%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB ELOC APOBEC3G RUNX1 RBX1 CUL5 UBB BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260410%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling IGF2BP1 BAD RPS6KA3 PRKAA1 FOXO3A TIAM1 PLCG1 SHC4 SHC2 SHC3 RASGRF1 CYFIP1 NGFR RPS6KA1 PDPK1 YBX1 VAV3 PPP2CA VAV2 CAMK1 NTF3 IKBKB IKBKG MAPK1 KIDINS220 HRAS MAPK3 MAP3K2 JUN MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK10 CDK5 GRB2 ARHG RAF1 CDH2 TSC2 IRS1 CAMK4 RPS6KA5 MEF2C RAC1 RPS6 HEL-S-15 NCF1 CREB1 MAP2K5 BDNF PIK3R2 PIK3R1 NCK2 NCK1 RAP1A EIF4EBP1 CDC42 FYN EIF4E STAT1 STAT3 PTPN11 MTOR RPS6KB1 ACACB GABRB3 GSK3B NCF2 MAPK8 CRTC1 GRIA2 NGF GRIP1 CASP3 SIRPA CHUK CDKL5 FRS2 FRS3 ADAM17 DOK5 KCNN2 GRIA3 NFKBIA EIF2S2 EEF2 EIF2S1 GRIN2B NFATC4 TRAF6 DOCK3 APC KSR1 SYN1 PRKAA2 KCNA3 CNR1 NCAM1 SQSTM1 SH2B1 LINGO1 NTRK3 MAPK7 RANBP9 MARCKS CDK5R1 SORT1 NTRK1 CSNK2A1 NTRK2 PTPRF GRIN1 NFKB1 SH2B2 CTNNB1 SRC RELA MAPK9 PTK2B STAT5B CAMK2A DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260410%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 DGCR8 DROSHA MRE11A ATM NBN DDX1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP4970%HOMO SAPIENS Galanin receptor pathway PPARG YAP1 INS CDKN1B CDKN1C POMC FOS BCL2L11 SLC2A4 CDKN1A IL6 VAMP2 CRP CREB1 VEGFA TAR SYNDROME%WIKIPATHWAYS_20260410%WP5362%HOMO SAPIENS TAR syndrome TXN STAT3 HLA-B HLA-C HLA-A ITGB1 HLA-F HLA-E FLT3 DDIT4 HDAC2 TNFRSF14 CD160 MET EGFR ANKRD35 EIF4A3 GPR89B CCAR2 AKAP10 SLK SUMO2 MAGOH SIRT1 NUDT17 CD3D SLC34A3 HEL-S-76p HFE2 RBCK1 CFTR SLC22A4 PEX11B FURIN NFKB1 CLCN3 BCL2L13 FARP2 ZFHX3 NHERF1 UBE2I POLR3GL PYM1 PDZK1IP1 POLR3C POLR3F POLR3G MITD1 HLA-G LAMTOR1 HAMP PEX19 IFNG CXCR4 LCK HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260410%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TGFB1 SNAI1 HDAC2 HDAC1 EZH2 PRRX1 FOXC2 KDM1A SUV39H1 SIX1 KLF8 SUZ12 TWIST1 ZEB2 ELF3 SIRT1 ELF5 GSC2 SNAI2 TCF4 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260410%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease VCAM1 SELE SELPLG ITGB1 MADCAM1 ITGA4 ITGB7 ITGA2 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260410%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis TNFSF6 BCL2 FAS CYCS CASP9 BAK1 CASP8 CASP6 CASP3 FADD DIABLO PRF1 BAX HTRA2 APAF1 AIFM1 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260410%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR DRAVET SYNDROME%WIKIPATHWAYS_20260410%WP5200%HOMO SAPIENS Dravet syndrome SCN8A MAPKAP1 SCN2A SCN4B SCN2B FGF13 MTOR NFKB1 PIK3CA CALM1 TNF MAPK11 SNTA1 PRKCA MLST8 STXBP1 SCN3B RICTOR SCN3A PRR5 SCN1B KCNA2 CAMK2A SCN1A PCDH19 CHD2 HCN1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260410%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome G6PC2 PRKAA2 G6PC3 PRKAA1 MAPK1 PRKAB2 MAPK3 PRKAB1 CRP ACACB ACACA ACLY SLC27A2 MAPK14 MAPK12 G6PC1 MAPK10 PRKAG1 PRKAG2 MAPK8 MAPK11 PRKAG3 HMGA1 MAPK9 MAPK13 PCK2 ERYTHROPOIESIS%WIKIPATHWAYS_20260410%WP5607%HOMO SAPIENS Erythropoiesis TNFSF6 KIT HBZ GDF11 TF HBG2 EPOR TFRC HBG1 EPO HBB FAS HBE1 HBD CD79A IL3 KITLG CD34 HBA2 PTPRC GATA2 GATA1 IL3RA BLADDER CANCER%WIKIPATHWAYS_20260410%WP2828%HOMO SAPIENS Bladder cancer ERBB2 MMP2 MMP9 EGFR PIK3R2 MYC FGFR3 PIK3R1 CXCL8 TYMP HBEGF UPK3A RASSF1 ARAF NRAS CDK4 MAPK1 HRAS CDKN2A EGF THBS1 MAP2K1 MDM2 MAP2K2 BRAF DAPK2 KRAS RB1 RAF1 CCND1 RPS6KA5 SRC CDKN1A VEGFA DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260410%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets CSF2 SPI1 CSF1 IKZF1 IRF4 BATF3 ID2 IRF8 STAT3 FLT3LG RUNX2 TPO TCF4 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260410%WP410%HOMO SAPIENS Exercise induced circadian regulation PIGF KLF9 NCKAP1 DAZAP2 BTG1 TOB1 PURA STBD1 SUMO3 UCP3 QK3 ERC2 RBPMS CEBPB CBX3 ZFR CRY1 G0S2 HEL-S-72p NR1D2 ETV6 SUMO1 PER2 PSMA4 PER1 CLDN5 H2BC15 AAG1 VAPA PPP1R3C HLA-DMA CRY2 MYF6 GSTM3 IDI1 HEL-S-22 FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260410%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling STAT3 CCR5 CCR6 FLT3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260410%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family AHR TSLP IL9 ID2 IL5 IL15 IF2B1 IL13 RORC IL25 ZBTB16 IL6 IL33 NFIL3 TBX21 RORA GATA3 IL17A GFI1 ATL1 TNF IL4 TOX IL7 IL18 AREG HNF1A IL1B IL12B IL12A IFNG IL23A KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260410%WP5351%HOMO SAPIENS Kleefstra syndrome PAXIP1 NR1I3 WDR5 BAP1 SMARCD1 MBD5 SMARCC1 SMARCD2 SMARCD3 ACTL6B ARID1A NCOA6 ACTL6A DPY30 ASH2L ARID1B SMARCC2 SMARCA4 PAGR1 RXRA KMT2C ASXL1 EHMT1 H3F3B ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260410%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction IFNAR1 ACE2 TNF IFNA1 NFKB1 TNFRSF1A TNF ALPHA SIGNALING%WIKIPATHWAYS_20260410%WP231%HOMO SAPIENS TNF alpha signaling TXN PRKCZ BAD PLK1 NFKBIE PSMD2 MAP3K8 BTRC NFKB2 REL TRAF1 BIRC2 MAP3K14 BIRC3 TNF TRADD CASP9 TNFAIP3 PIG59 MAPK8 NFKBIB CASP8 TBK1 TRAF2 CYBA CASP3 CHUK FADD OTUD7B MAP3K7 SMPD2 SKP1 RIPK3 MAP4K2 FBXW11 NFKBIA KSR2 MAP3K7IP1 MADD PPP2CA APAF1 PTPRCAP NSMAF TANK KSR1 RFFL IKBKB TNFRSF1B IKBKG CDC37 MAP3K5 NRAS CSNK2A1 MAPK1 HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 BAX JUN MAP3K1 BCL2L1 NFKB1 TNFRSF1A CREBBP PYGL RIPK1 GRB2 KRAS SOS1 RAF1 TAB3 RAC1 DIABLO MAPK9 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260410%WP408%HOMO SAPIENS Oxidative stress response NQO1 UGT1A3 NOX3 NOX5 NOX4 XDH HMOX1 GCLC TXN2 HEL-S-44 CYP1A1 GSTT2 SP1 FOS NFE2L2 NFKB1 MAPK14 MAPK10 TXNRD2 JUNB GPX1 GPX3 CYBB HEL-75 MAOA MGST1 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260410%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 GCG SLC2A2 SLC5A1 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260410%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 HBA2 MB HBB AOX1 XDH TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260410%WP5496%HOMO SAPIENS Targeted therapy in breast cancer ERBB2 ERBB4 PIK3R4 EGFR PIK3R2 KRAS PIK3C2G PIK3R1 PIK3C2A RAF1 ERBB3 PIK3C2B AKT3 PIK3CD NRAS MAPK1 HRAS MAPK3 PIK3R3 PIK3R5 PIK3CA SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260410%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome RAP1A SPAAR CTNND2 CDC42 ARHGAP44 SHARPIN SYNGAP1 DLGAP1 LZTS3 HOMER1 BAIAP2 DLG4 HRAS ADGRL1 ARHGEF7 SHANK3 ITGB1 GRIN1 PAK1 PS1TP5BP1 GRIA2 MAP3K7 SPTAN1 CAMK2A GRIN2B HCN1 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260410%WP3601%HOMO SAPIENS Lipid particles composition LPL APOA2 APOC3 APOE APOB APOC2 LDLR PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260410%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases STAT3 KHK MYL2 AKT1S1 HEL-S-68p H3F3B SNAP23 H2AX HEL-S-30 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260410%WP5028%HOMO SAPIENS Glycine metabolism including IMDs ISCU DLD HEL-S-302 SHMT1 LIPT2 LIPT1 GLDC AMT HSCB LIAS NFU1 GCSH BOLA3 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260410%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H4C9 HIST1H4L H2AX HIST1H2AB H2BC15 H2AC19 H2AC14 H2BC26 H2BC12L H2BC21 H2BC9 ACD H2BC8 H2AC6 H2BC3 TINF2 H2BC1 TERF2 TERF1 H2BC17 TERF2IP H2BC12 H2BC13 H2BC14 H3-4 H2AC20 H2BC11 POT1 HIST1H2BE TPP1 H2AZ1 H2AZ2 H2AB1 H2AJ HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260410%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease SMAD2 AGTR1 FLNA MAPK8 MAPK1 ANGPT2 SMAD4 MAPK3 FBN2 FBN3 RUNX2 POSTN TGFBR1 LTBP2 TGFBR2 NR2C2 LTBP1 TGFBR3 MAPK14 FBN1 CTGF ENG MONOAMINE GPCRS%WIKIPATHWAYS_20260410%WP58%HOMO SAPIENS Monoamine GPCRs CHRM3 5HT1A CHRM1 CHRM4 CHRM5 HTR2B ADRB1 HRH1 CHRM2 HRH2 DRD5 HTR1E HTR1F HTR1D HTR1B ADRA2C HTR5A ADRA2B ADRA2A ADRB3 HTR4 HTR6 HTR7 ADRA1D ADRA1B ADRB2 ADRA1A DRD2 DRD3 HTR2A DRD4 DRD1 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260410%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HCN4 KCNE1 HAND2 ERG KCNJ2 TMSB4X HCN2 IGF1 GJA1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260410%WP5601%HOMO SAPIENS Caffeine in blood vessels HEL-S-80p CALM1 PPP1R12C ADCY1 PDE4D ADCY8 RYR2 ADCY6 ADCY3 ADCY9 RYR3 GUCY1A2 PDE3B ADORA2B PDE3A PDE4B ADORA2A ADRA1D PDE4A ADRA1B ADRA1A MYLK VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260410%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases NFATC1 NR3C1 TNF IKBKB IKBKG NR1i1 CHUK MAP2K6 SMAD4 RELA IL6 MAP2K3 RXRA PPP3CA NFKBIA MAP3K1 PPP3R1 MED14 NFKB1 MAPK14 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP4478%HOMO SAPIENS LTF danger signal response pathway IL1A TLR4 MYD88 CXCL8 AGER TNF CD14 TREM1 MAPK1 IRAK1 IL1B IFNB1 IL6 IRAK4 IFNA1 HEL110 NFKB1 TRAF6 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260410%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts B3GALT6 HS3ST3A1 CHPF XYLT2 HS6ST1 HS6ST2 HS2ST1 HS6ST3 EXTL2 XYLT1 EXTL1 CHSY1 CHST12 NDST3 CHSY3 CHST13 CHST14 HS3ST3B1 CSGALNACT1 CHST7 CHPF2 B3GAT3 CHST11 B3GAT2 GLCE B3GAT1 CSGALNACT2 HS3ST1 HS3ST2 EXT1 EXT2 UST CHST1 CHST3 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260410%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TMEM67 RAB23 EVC2 BBS2 BBS1 SCLT1 FUZ INPP5E TTC8 MKS1 IFT27 CLUAP1 TTC23 C2CD3 CEP19 CBY1 EFCAB7 TXNDC15 TCTN3 TCTN2 TCTN1 CDK20 TRAPPC11 KIFAP3 CEP97 CC2D2A IFT56 OFD1 DYNC2I2 DYNLT1 CEP295 TRAF3IP1 ARMC9 IFT172 RPGRIP1L CCDC41 KIF3A CEP20 IFT52 IFT46 TEDC1 IFT70B TMEM107 TEDC2 FBF1 KATNB1 BBS9 TUBD1 BBS7 KIF3B IFT57 KIAA0753 BBS5 CEP192 MIB1 CEP76 RABL2B BBS4 CPLANE1 DYNC2H1 TUBE1 CPLANE2 TMEM231 IFT140 IFT20 IFT80 TMEM17 SASS6 WDR35 CEP162 LZTFL1 B9D1 EVC CIBAR1 BBS10 CEP44 IFT43 IFT25 BBS12 IFT81 TMEM216 WDPCP PIBF1 CEP104 ARL6 ARL3 DNCL1 DYNLT2B DYNC2LI1 IFT74 ARL13B LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260410%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ACE2 FADS2 ELOVL5 ELOVL2 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome ATR ATM RNF168 CBX3 H2AX NIPBL MDC1 RNF8 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260410%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CALM1 BDNF RPS6KA1 NCAM1 BCL2 PPARGC1A CCND2 CAMK4 CAMKK1 SYT2 CAMKK2 NRXN1 PRKCA NRXN3 RPS6KA5 MAPK1 DRD1 NRXN2 NGF PRL HNRNPL CAMK2A CREB1 MAPK14 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260410%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MYD88 IRF9 IFNAR1 IFIH1 EIF2AK2 MAVS IKBKB OAS1 OAS2 RIGI IKBKG STAT1 STAT2 FOS JUN NFKB1 MAPK14 RIPK1 MAPK8 TBK1 IKBKE JAK1 CHUK IFNAR2 MAP3K7 TYK2 TICAM1 NFKBIA IRF3 TRAF3 TLR7 TRAF6 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260410%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy GPD1 PPARG HIF1A HMFN0839 CD36 HEL-S-162eP HEL-S-49 HEL-S-133P SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260410%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CADM3 CAMK2G CADM1 CASK ATP2B1 SNW1 DAB1 KCNMA1 EPB41L3 KCNQ2 PRKCZ GRIK2 AGRN MAPK4 GRIN1 PLCB4 NEO1 CDH2 RAP1GAP TERF2IP GABRG2 CSN3 GPHN MAPK9 CHL1 EFNA5 NCDN MAP4 STX2 CLASP1 NTNG1 GRIN2B GABBR2 CAV2 KCNJ6 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260410%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 IL1B PYCARD NFKB1 NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP61%HOMO SAPIENS Notch signaling PSEN2 RBPJ HES5 PIK3R2 SNW1 PIK3R1 EP300 FHL1 DTX1 APH1B NCOR2 MAGEA1 FBXW7 CIRSR PSENEN NOTCH2 SPEN NOTCH3 SAP30 STAT3 NCOR1 MTOR ITCH MAML3 MAML1 NFKB1 NUMB HDAC2 HDAC1 JAG2 GSK3B HEY2 HES6 PSEN1 SRC NOTCH1 SKP1 ADAM17 DLL3 DLL4 LCK MAML2 HES1 IL18 SIGNALING%WIKIPATHWAYS_20260410%WP4754%HOMO SAPIENS IL18 signaling PTEN PIK3R1 CSN2 SP1 IL18RAP PRKAA1 IMP3 IRF1 SLC12A3 RPS6KB1 IL18R1 CEBPB ACACB IL37 GSK3B NCF2 TNF CASP8 IRAK1 CASP3 CHUK MAP3K7 HEL-S-102 NFKBIA PARP1 GRIN2B TRAF6 NFATC4 ELAVL1 TNFSF6 MYD88 FAS CYCS IKBKB MAPK1 MAPK3 BAX NFKB1 TNFRSF1A TICAM2 IL18 PRKCB PRKCA CTNNB1 RELA MAPK9 GATA1 NCF1 LCK IL2 SIGNALING%WIKIPATHWAYS_20260410%WP49%HOMO SAPIENS IL2 signaling PIK3R1 CBL SOCS3 FYN STAT1 MAPK1 STAT3 FOXO3A PTPN11 HRAS MAPK3 RPS6KB1 CISH NMI MAP2K1 RPS6KB2 MAP2K2 GRB2 SOS1 IL2RG RAF1 IL2 JAK3 IL2RA CRKL IL2RB SYK JAK1 RPS6 PTK2B GAB2 STAT5B LCK CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP5304%HOMO SAPIENS Cholesterol metabolism HMGCS1 HMGCR TM7SF2 LIPG HSD17B7 PBR ANGPTL8 ANGPTL3 LRPAP1 SAR1B NPC1L1 APOH MGAT1 CIDEB VAPA ACAT2 ABCB11 CYP27A1 LPL SCARB1 NPC1 PCSK9 LIPA CD36 APOE APOB LDLR ABCA1 MYLIP STARD3 SORT1 APOA4 FABP2 SOAT1 STAR NPC2 MTTP CYP7A1 APOC2 LIPC APOC1 LPA PLTP ABCG8 SLC27A4 ABCG5 DGAT1 APOA2 APOC3 IDI1 FDPS MVK CYP51A1 DHCR24 MSMO1 SQLE EBP PMVK SC5D MVD DHCR7 LBR FDFT1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260410%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO1C1 SLCO3A1 SLCO4A1 SLCO1A2 SLC16A10 SLC16A2 SLC7A5 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260410%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis HSD3B2 POR STAR HSD17B3 SRD5A2 HSD17B6 CYP17A1 AKR1C2 AKR1C4 CYP11A1 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260410%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ACTN1 ITGB3 MYL2 TJP1 LPP ITGAV MAPK1 PXN PRKCQ PLCG1 MAPK3 MFAP5 JUN HEL114 CREB1 MYLK THERMOGENESIS%WIKIPATHWAYS_20260410%WP4321%HOMO SAPIENS Thermogenesis RPS6KA6 RPS6KA3 ARID1A PRKACG ADRB3 PRKAA1 MTOR PRKAB2 ADCY9 SIRT6 RPS6KB1 PRKAB1 FGFR1 SMARCE1 FACL4 PRKG1 PRDM16 RPS6KA1 PPARG PPARGC1A SMARCD1 ACTG1 DPF1 ADCY3 PRKAG1 DPF3 SMARCC1 PRKAG2 CPT1C SMARCD2 ZNF516 SMARCD3 ACTL6B KDM3A KDM3B PS1TP5BP1 ACTL6A UCP1 PRKAG3 HEL-S-7a SLC25A29 ARID1B SLC25A20 BMP8A SMARCA4 FRS2 BMP8B GNAS AKT1S1 MAPK13 PRKAA2 CNR1 ATF2 GCG ADCY1 LIPE ADCY8 FGF21 ACSL3 ADCY6 ACSL1 MAP3K5 PLIN1 NRAS ACSL6 MGLL ACSL5 PNPLA2 TSC1 HRAS SMARCC2 MAP2K3 RHEB RPS6KB2 MAPK14 MAPK12 GRB2 KRAS SOS1 SOS2 CREB3L3 TSC2 CREB3L4 CREB3L2 MAPK11 KDM1A RPTOR RPS6KA2 MLST8 CPT2 CPT1A CREB3 RPS6 CREB5 CREB1 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism EPHX2 ALOX5 ALOX15 CYTOSINE METHYLATION%WIKIPATHWAYS_20260410%WP3585%HOMO SAPIENS Cytosine methylation HEL-S-26 MBD3 TET2 TET1 TDG SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260410%WP3947%HOMO SAPIENS Serotonin and anxiety 5HT1A PLCD4 PLEK POMC HTR2A PRKCB TRPV1 ARC FOS PPP3CA EEF2K CRH FMR1 ADRA1A GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260410%WP4815%HOMO SAPIENS Glycosaminoglycan degradation GNS SGSH GALNS GLB1 HYAL2 HYAL4 HPSE GUSB HGSNAT HPSE2 IDUA HEXB HEXA ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260410%WP554%HOMO SAPIENS ACE inhibitor pathway TGFB1 AGTR2 ACE2 AGTR1 CMA1 ATP6AP2 MGRA NR3C2 CTSG BDKRB2 BDKRB1 REN KNG1 CYP11B2 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway IDI1 FDPS MVK HMGCS1 CYP51A1 MSMO1 SQLE HMGCR PMVK SC5D MVD DHCR7 FDFT1 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260410%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STRADB PRKAA1 PTBP1 STK11 SIX4 CTDSP1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260410%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHA SDHB ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2853%HOMO SAPIENS Endoderm differentiation SMAD2 EZH2 SOX2 TOX TET1 PTHLH VAV3 TCF4 ELAVL1 FOXO1 FOXA1 APP SOX21 MAP2K3 CEP250 HOXA1 WWC1 SOX7 WDHD1 SFMBT1 DNMT3B TBX21 FOXH1 CDYL EMSY RFX7 OTX2 RAB38 WDFY2 HPRT1 CTR9 GATA6 PRDM14 RTF1 MBTD1 EPB41L5 UBR5 NKX2-1 BPTF ATP8B2 SIAH2 FOXN3 GDF3 ZFHX4 TRERF1 SP4 LHX1 NABP2 NOTCH1 PAF1 TAF4B LEF1 PLCH1 TCF2 NODAL WNT8A PIAS1 TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 C1QBP JARID2 DUSP4 DUSP5 DUSP2 SLC2A12 PAX3 PARP8 NR1B3 TOX3 AEBP2 Pax9 PABPC1 STAT1 AHDC1 CAND1 BTAF1 TCEAL2 LEO1 BCORL1 KDM4A ZNF462 ELP4 ZIC5 LRPPRC MAD2L2 TNRC6C ACACA RGS10 CEBPZ TAF5 SESN1 MIXL1 TGFB1 BMP7 FOXA2 CUL4B LAMC1 CRTC1 SMAD4 EXT1 POU5F1 APC SOX17 CER1 PBX3 DKK1 SFRP1 NR3C1 CTBP2 NLK NOG GATA4 PBX1 WNT3 CTNNB1 TCF7L1 BMPR1A MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260410%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes RAB23 CDK6 EZH2 ABCG2 IGF2BP1 SERPINE2 PLXND1 ARID4B DCAF7 TXN2 PNP CHORDC1 MAP3K8 GOLGA7 CDK5RAP3 FADS1 VPS39 ATP6V0E1 TNLG5A TNFRSF10B IFRD1 HEL-S-66 PISD MTHFD2 RAB34 PPIF TERT PPIB ANAPC1 MYO1E POM121 DDX5 RAB5C TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 RDH10 KCNN4 SAC3D1 MPDU1 ATP6V1F SNX6 CD164 PHC2 BRPF3 HMGA1 TBCA IGF2R BCL6 CDKN1A MENT CLDN1 SFXN1 SLC25A1 ARF4 ADPGK SNAP23 TNFAIP2 ATP2A2 MRC2 GYS1 KIT TUBA1A SPTLC1 RHOB YWHAQ TMEM43 TMED3 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC HMOX1 SCYL1 CAP1 PTBP1 ANXA2 PRPF40A HEL-S-26 SLC7A6 CDCP1 CDKN2A RFT1 FRG1 PTRH1 UNC93B1 TYMS RHEB PPP3CA HEL-S-47e EHMT1 PTPA DNAJB1 FGF2 DNMT3B POLR2C USP1 SHOC2 CDIPT SRSF10 AP3D1 ARHG ARCN1 WDR11 POLE4 FMNL2 TDG POLD2 COL4A2 MYB PRKCI NOTCH1 BACE1 MCL1 C1QBP BDNF AP2A1 PXDN CXCL12 NF2 CAND1 GFPT1 NEDD4 SMAD1 CEBPB LAMC2 CUL4B CPNE8 LAMC1 VEZT TMEM41B PWP1 RRP8 MTRR TCL1A DHX57 LOC541469 RAVER2 CIAO2A SEC62 HOXA5 HEL-S-30 ARL10 ITGA2 MBNL1 SLC38A1 HEL-S-303 TRAM1 CBFB CACNA2D1 FNDC3B CSNK1D FNDC3A CARHSP1 WDR82 OTULINL HACD3 IQGAP3 UBE2J1 FXR2 COMMD9 GRPEL2 CEP72 ATP6V1C1 VTI1B HARS1 RAB27B BRI3BP UHRF1 PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 MAPK7 STRN ANP32B FERMT2 MYLIP HOXD8 RNP24 RCOR1 GFM1 MAGT1 MEOX2 PANX1 COIL SERP1 DHX15 GNPNAT1 TMED7 MRPS24 ELMOD2 TMT1A PSAT1 AP3B1 CSDE1 VAMP3 PRIM1 MRPS33 SSNA1 AKAP8 NAPG NT5E PGRMC1 PPP1R7 TAF9B MPZL1 MTX1 SMC1A SPRYD4 CDKN1B TRMT1 TTC9C ATAT1 TMEM59 SPCS3 TPPP3 GPAM NFIA AXL SNX15 PKN2 TRIP13 LAMTOR5 LY6K SLC25A13 GEMIN2 FAR1 LTN1 MSI2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 KPNA3 BACH1 RARS1 ATG9A STX7 UBE4A CDKAL1 RAB30 SYPL1 ADAR GPD2 NCL PLK1 PTMAP7 GEMIN7 SRSF9 RAI14 SDCBP NPRC GAS2L1 SLC4A10 PURA TNFRSF10A GNL3L TRPV6 UBE2S P4HA2 CHMP2A SRPRB DKFZp761E1322 PICALM DOCK5 CALCOCO2 DOCK7 CYR61 SYNE2 SYNE1 SNAP29 UTP15 HSDL1 MARS2 RBM19 SIGMAR1 PPP2R5C RCN2 RBMS1 SEC23A LUZP1 NUFIP2 NXN PLAG1 HSD17B12 GNA13 MRM1 AURKB TP53INP1 ASH2L SH3BP4 ZNF622 ABCF2 SLC25A22 PDLIM7 SLC25A24 SLC12A2 FBXW11 GALNT7 NHERF2 TM6SF1 SLC4A7 CPOX RQCD1 SLC25A32 LPL BET1 EGFR CYP1B1 ATG3 GALNT1 NRP1 CHAF1A HEL-S-273 HEL-S-108 TPM3 MAPK14 MAPK12 TPM1 KRAS LAMTOR3 GSTM4 IRS1 CYP51A1 VCAM1 EIF4E NOTCH2 ARID1A PDE3A PPP3R1 SUCLG2 RB1 E2F3 LMNB2 CCND1 CDKN1C TGFBR2 NT5C3A MET AMIGO2 BCL2 PTPRF FADS2 ELOVL5 CTNNB1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260410%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260410%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260410%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism SLC44A1 CHDH ALDH7A1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260410%WP4146%HOMO SAPIENS Macrophage markers CD74 CD163 CD83 CD68 F3 LYZ CD14 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer BLM CHEK2 PTEN MYC SMAD2 BARD1 CDKN2B BAD PLK1 CDC2 CDC25B MSH6 MSH2 CDK4 NOXA1 PIK3CA DOCK1 SMARCD1 SMARCC1 SMARCD2 SMARCD3 ACTL6B ACTL6A ARID1B SMARCA4 CDKN1A MAP4K1 SPINK1 EIF4E1B FKBP5 ETV4 TSC1 MAPK1 FOS HRAS CDKN2A FOXA1 MAPK3 RHEB JUN MAP2K1 CDK2 MDM2 MAP2K2 MAPK14 GRB2 SOS1 RAF1 TSC2 CRKL RPTOR HSD3B2 JAK1 RAPGEF1 CRK RAP1A EIF4EBP1 ARID1A STAT1 SP1 STAT3 PTPN11 HSD17B1 MTOR HSD17B2 ERG HSD3B1 SPRY2 HSD17B3 HSD17B4 F13B HSD17B7 CYP17A1 CPN1 RB1 PRKDC KLK3 CCND1 CASP9 MAPK8 PAK1 CASP8 CASP3 HGF BCL2 CHEK1 ATR SMARCC2 SPRY1 BAX RAD50 MRE11A ATM BRCA1 CDKN1B PXN PTK2B RICTOR ATF1 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260410%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions MMP9 SMAD2 EBI3 FOXO4 SOCS3 CDC42 STAT4 CXCL12 STAT1 STAT3 FOXO3A CTLA4 NFKB2 IL33 NKX2-2 CXCL1 TGFB1 IGF1R FOXP3 IL2RG IGF1 TNF ROS1 PDGFA ITGAV IL2RA ITGA2 IL2RB AREG SSTR2 SIRPA CCR8 IL12A CNP CSPG4 CCR6 IL10 TGFBR1 TGFBR2 TGFBR3 HEXB TLR4 CX3CR1 AIF1 MYD88 CD47 EGFR CD44 CCL1 CD68 FOXO1 TNFRSF1B IKZF2 CCN3 NKX6-2 OLIG1 NOS2 OLIG2 FAM20C MBP APOD NKX6-1 KLRG1 MOG IL6 IL10RB MCAM IL10RA TMEM119 PDCD1 HTR7 CCL20 NFKB1 MAPK14 CD80 ITGB3 IL2 IL4 PDGFRA SPP1 JAK3 IL18 SOX9 RAC1 JAK1 IL1B GSDMD IFNG TYK2 STAT5B IL12RB1 OSM NLRP3 VEGFA ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway UGT1A3 NR1I3 UGT1A9 CYP2C9 EHHADH FOXO1 CYP2B6 CYP2C19 NCOA1 SP1 RXRA SULT2A1 PTPA UGT1A4 CYP2A6 DNAJC7 ABCC3 SULT1A1 ABCC2 ABCB1 UGT1A1 PPARGC1A SMC1A NCOA6 CYP4A11 ALAS1 CYP3A4 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260410%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence S1PR2 S1PR5 PLCB1 RPP38 SPTLC1 GLB1 SPHK1 RB1 SGMS2 SGPP1 UGCG PRKCB KDSR CDK4 PRKCA MAPK1 MTOR CDKN1A CERS2 CDK2 TERT S1PR1 DEGS1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260410%WP474%HOMO SAPIENS Endochondral ossification MMP9 STAT1 RUNX3 ALPL HMGCS1 FGFR1 TGFB1 BMP7 IGF1R IGF2 IGF1 CDKN1C PTCH1 FRZB IHH CHST11 GLI3 THRA PTH1R PTHLH COL2A1 ACAN FGF18 FGFR3 ENPP1 KIF3A RUNX2 FGF2 CALM1 ADAMTS4 GHR PTH ADAMTS5 COL10A1 TIMP3 PLAT SOX6 NKX3-2 SOX5 SPP1 DDR2 CAB39 CST5 SCIN BMP6 GH1 MGP SOX9 MEF2C STAT5B VEGFA BMPR1A PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2876%HOMO SAPIENS Pregnane X receptor pathway ABCC3 UGT1A3 ABCC2 ABCB1 UGT1A1 UGT1A9 CYP2C9 PPARGC1A FOXO1 CYP2B6 CYP2C19 NCOA1 SLCO1B1 NR1i2 CYP4F12 CYP3A7 SRC SRPX2 RXRA SULT2A1 UGT1A4 CYP2A6 DNAJC7 CYP3A4 ANGIOGENESIS%WIKIPATHWAYS_20260410%WP1539%HOMO SAPIENS Angiogenesis MMP9 TIMP3 PDGFRA KDR MAPK1 SRC PLCG1 ANGPT1 HIF1A SMAD1 FGFR2 FLT1 FGF2 CREBBP MAPK14 VEGFA PIK3CA MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260410%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN VEGFB HIF1A VEGFC VEGFA HES1 ATM SIGNALING%WIKIPATHWAYS_20260410%WP2516%HOMO SAPIENS ATM signaling CHEK2 GADD45A ATF2 TLK1 CHEK1 CDC2 H2AX IKBKG MDM4 RAD9A CCNE1 JUN CDK2 MDM2 MDC1 CASP2 RAD50 RIPK1 MRE11A ATM BRCA1 NBN TP53BP1 TP73 SMC1A RAD51 PIDD1 CDKN1A CCNB1 MAPK9 CRADD CREB1 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260410%WP2289%HOMO SAPIENS Drug induction of bile acid pathway ABCC3 ABCC2 ABCB1 NR1I3 SLC51A BAAT SLC51B ABCB11 NR1i1 SLCO1B1 NR1i2 NR1H4 SULT2A1 CYP7A1 CYP3A4 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome UGT1A10 UGT1A9 IRF8 PER2 HEL-S-28 CXCL11 SH3BP4 ASCL1 GYS1 UGT1A3 EGFR MAP1LC3A PDX1 JUN PDCD1 UGT1A4 CALM1 BOK UGT1A1 ITGB3 HES6 MEF2C RAC1 IL1B RPS6 CXCR4 MROH2A DGKD NDUFA10 HJURP ERFE KLHL30 GABARAPL2 GABARAPL1 EEF1A1 THAP4 RRAGA RRAGB IL13RA1 RRAGD CALCA CALCRL TWIST2 AGAP1 GABARAP NEU4 CXCL12 OR6B3 TRPM8 OR6B2 NEDD8 UBE2F MTERF4 RAB27A COPS8 COPS9 SNED1 RTP5 RNPEPL1 PRH ING5 SEPT6 MAP1LC3C KIF1A GAL3ST2 ILKAP MYOG AQP12B AQP12A ITPK1 DUSP28 ANO7 OTOS ARL4C MYOD1 USP40 AGXT TNF PDGFA ARF5 DTYMK ASB18 CENPA CYTH2 GBX2 GPC1 SPP2 D2HGDH UGT1A8 ANKMY1 CYTH1 UGT1A7 SEPTIN2 SEPTIN4 MLPH CAPN10 NFKBIA RAB17 RAMP1 ASB1 TRAF3 DKFZp762B153 ABCA1 TRAF3IP1 ACKR3 DISC1 ARF1 FARP2 PPP1R7 HAMP PRL MAP4 HES1 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP5171%HOMO SAPIENS Leukotriene metabolic pathway PTGR1 ABCC1 ALOX5 DECR1 CYP4F3 DPEP2 ALOX5AP LTC4S DECR2 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP10 PLK1 DVL1 RBX1 DVL2 DVL3 CTNNB1 TNK1 BTRC AXIN1 SKP1 PARP1 TNK2 APC BDNF TRKB SIGNALING%WIKIPATHWAYS_20260410%WP3676%HOMO SAPIENS BDNF TrkB signaling TRPC3 BDNF ADCY1 EIF4EBP1 NRAS NTRK2 HOMER1 MAPK1 TSC1 DLG4 HRAS MTOR PLCG1 RPS6KB1 RHEB TRPC6 GRIN1 MAP2K1 BRAF GRB2 RPS6KA1 KRAS SOS1 TSC2 ARC GAB2 EEF2K CREB1 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 TNFRSF13C CD79B SPIB MYC TCF3 ICOSLG POU2AF1 EZH2 ID3 CD79A CCND2 IRF8 STAT3 CDKN2A IL6 BCL2L1 IL21R NFKB1 POU2F2 LYN SPI1 CCND3 CD40 BCR TLR3 CDKN1B IRF4 SYK MEF2C BCL6 CDKN1A TLR1 MEF2B TLR9 TLR8 TLR10 TLR7 TCF4 TLR5 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260410%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 CDKN1A ID1 ID2 USP1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260410%WP2328%HOMO SAPIENS Allograft rejection PRKCZ CXCL12 C4A CXCL13 IL5 STAT1 CD40LG CTLA4 HLA-B PECR HLA-C HLA-A HLA-F C4B_2 HLA-E TGFB1 FOXP3 ABCB1 HLA-DMA C1QB C1QA TNF CXCL11 CASP9 IL2RA CASP8 CXCL9 CASP3 IL12B GABPA IL12A GDNF C1QC IL10 IL1A HARS1 TNFSF6 CXCR5 CXCL8 FAS LRRK2 TUBA1B GNLY HLA-DOA HLA-DOB HLA-DPA1 BHMT2 IF2B1 IL13 HLA-DQB1 C2 CSNK2A2 HLA-DMB HEL113 CCL19 HLA-DQA2 MICA CD55 HLA-DQA1 IL-21 HLA-DRB5 HLA-DPB1 CCL21 HLA-DRA HLA-DRB1 IL17A CD40 CD80 AGTR1 IL2 IL4 PDGFRA HLA-G IL1B IFNG C6 PRF1 C7 HEL-S-62p C9 C8A VEGFA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260410%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TBK1 IKBKE IFNB1 TOMM70 MAVS IRF3 RIGI TRAF3 TRAF6 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260410%WP4316%HOMO SAPIENS miRNA degrading enzymes PNPT1 EXOSC4 XRN1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260410%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle ADAM10 DUSP14 IL1A IL1R1 NR4A3 ATF3 HBEGF EIF4EBP1 IL18 EIF4E ANKRD1 IFNG IFRD1 JUND MYOG HEL-S-52 CYR61 VEGFA GDF8 CREATINE PATHWAY%WIKIPATHWAYS_20260410%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260410%WP5061%HOMO SAPIENS Fatty acid transporters FABP9 DBI FABP5 CD36 ACSL3 ACSL1 ACSL6 ACSL5 FABP6 FABP1 FABP2 FABP4 FACL4 SLC27A4 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260410%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 EGR1 SOX2 TRIM71 POU5F1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260410%WP5050%HOMO SAPIENS TCA cycle in senescence PDP2 ME1 FH ME2 PDHA1 HEL-S-32 BRAF AUTOPHAGY%WIKIPATHWAYS_20260410%WP4923%HOMO SAPIENS Autophagy PRKAA2 PIK3R4 ATG9A DKFZp762B153 ATG3 UVRAG AMBRA1 ATG14 ATG12 ATG16L1 PRKAA1 MTOR PRKAB2 PRKAB1 ULK1 DEPTOR RB1CC1 ATG101 WIPI2 PRKAG1 PRKAG2 RPTOR PRKAG3 MLST8 AKT1S1 ATG5 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP3995%HOMO SAPIENS Prion disease pathway NCAM1 EP300 BCL2 FYN MAPK1 STAT3 MAPK3 RXRA FGFR1 NFKB1 POU2F2 HEL-S-125m RAD21 SPI1 SMC3 IRF4 CTCF HEL-S-89n CASP12 PRNP TBP BCL11A HEL-S-269 PAX5 BATF CASP3 MEF2C RFX5 CHD2 CREB1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260410%WP697%HOMO SAPIENS Estrogen metabolism NQO1 GSTM1 UGT1A3 SULT1A1 UGT1A1 CYP1B1 UGT1A9 CYP1A1 STS SULT1E1 ARSL UGT2B7 CYP3A4 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260410%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport MTR DHFR HEL-S-51e SHMT1 TYMS SLC46A1 HEL-S-70p MTHFS FTCD MTHFD2 MTHFD1 MTHFD2L FOLR1 SLC19A1 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260410%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF ISCU LYRM4 ABCB7 FDX1 FDXR CIAO2B FXN NUBP1 NUBP2 HSCB NFU1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260410%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADRA2A HEL-S-7a ADCY9 ADRB1 ADCY1 ADCY8 ADCY6 ADCY3 ADRA1D ADRA2C ADRB2 ADRA2B ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment CHUK IL6 RELA TNF NFKBIA IKBKB IKBKG NFKB1 MUC1 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260410%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP2 MMP9 PIK3R4 BDNF PAK6 EPHB6 TRIO EPHB1 EPHB4 ARHA EPHB3 PAK4 STAT3 TWIST1 FOS F2RL2 TIAM1 ARF1 JUN PIK3R3 PIK3R5 PIK3CA NGFR AKT3 PIK3CD PAK1 EPHB2 RAC1 CDH11 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260410%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer TIGAR PGAM1 PYCR2 PAICS HEL-S-51e GLUD1 ALDOB HK3 FH MDH2 PSAT1 FASN SDHB ACLY RPIA SUCLG2 PFKL ACO2 GOT2 HEL-S-30 PSPH HEL-S-133P GLS SLC16A3 ENO1 PDHA1 HEL-S-68p HEL-S-162eP HEL107 CILIARY LANDSCAPE%WIKIPATHWAYS_20260410%WP4352%HOMO SAPIENS Ciliary landscape MFAP1 BBS2 NEK8 BBS1 FUZ DCAF7 BBIP1 MSH2 TTC8 DGKE MKS1 SMC4 IFT27 MAEA APMAP RAB2A CLUAP1 ARMC8 MYL6 TIPRL ERF ARL8B INTU COPS7A HEL-S-296 DOCK5 CDH23 NUP88 CDR2 AAR2 POM121 CTSA DDX5 TFAP2B SNAP29 TFAP2C UBE2H TFAP2D TFAP2E EXOC6B CNOT10 LSM4 COPS4 COPS6 IFT22 EHD3 COPS5 CNOT1 WNK1 LCN2 RANBP10 DYNLRB2 MCM7 ZMYND19 MCM9 NEF3 MCM10 MYL6B RPGR NEFL CEP170 TMED1 DFNB31 NINL RAB8A EIF5B RQCD1 RBM14 NUDC CNOT6L EXOC8 NUP133 GLB1 EIPR1 DYNLT3 RAB3IL1 ECHS1 ARFGAP3 YAP1 RABEP2 ACSL3 NME8 MCM3 EXOC4 EXOC3 EXOC6 MCM5 MCM6 EXOC5 MAPRE2 EXOC2 HEL113 PAFAH1B1 CCDC40 EXOC1 IFT70A WDR26 ANKS3 VPS4A HEL-S-47e USH1C RAB21 RMND5B GDI1 DNPEP CREBBP PGRMC2 RMND5A SNRPB2 CALM1 UQCC NDUFA9 NDUFA5 MKLN1 GID4 RAB14 VAPB XPNPEP3 GID8 YPEL5 GLA DYNC1H1 DYNLL2 RAC1 DYNC1LI1 DNCL1 IQGAP1 H3F3B PSMD12 WEE1 HEL-S-91n PSMD13 UBE2D2 CBS PSMD7 COPS8 LRPPRC EXOC7 PSMC6 PSMC4 HDAC2 HDAC1 RB1 IQGAP3 APC RHBDD2 RANBP9 CEP97 IFT56 STOM DYNC2I2 DYNLT1 TRAF3IP1 IFT172 IFT52 IFT46 IFT70B BBS9 BBS7 IFT57 TBC1D4 BBS5 MCM2 EXOSC4 NFKB1 CEP290 BBS4 SSNA1 IQCB1 CTBP2 IFT20 IFT140 IFT80 LZTFL1 IFT25 IFT43 DVL3 IFT81 TFAP2A CTNNB1 EFHC2 HTRA2 DYNLT2B RALB CAMK2A IFT74 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260410%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway NQO1 TMPRSS2 CXCL8 ACE2 KEAP1 IKBKB CCL2 HMOX1 GCLC IKBKG IL6 RXRA GUCY1A2 GUCY1B1 NFE2L2 NFKB1 TNF GCLM MMP3 CHUK IL1B RELA IL12A NFKBIA IRF3 SLC7A11 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260410%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA6 PIK3C2G PIK3C2A RPS6KA3 MAP3K8 PRKAA1 FOXO3A NR1H3 PRKAB2 PRKAB1 SHC2 SREBF2 SHC3 SCD SESN3 PIK3R3 FASN ANGPTL8 PIK3CA G6PC1 SLCO1C1 RPS6KA1 PDPK1 SLC16A2 PRKAG1 PRKAG2 PRKAG3 THRA MAP4K1 MAP4K2 MINK1 MAPK13 CYP3A4 LPL GYS1 FOXO1 CAP1 MAP3K5 MAP4K3 TSC1 MAPK1 HRAS MAP2K6 SLC2A4 MAPK3 MAP3K2 MAP2K3 RHEB MAP2K4 MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK12 MAPK10 SOS1 RAF1 MAP3K6 SOS2 MAP3K12 TSC2 IRS1 PCK1 CBLC MLXIPL PIK3CD FBP1 RPS6KA2 RPTOR TRIP10 RPS6KA4 RPS6KA5 MLST8 NR1A2 RAPGEF1 MAP2K5 CRK PIK3R4 MAPKAP1 PIK3R2 PIK3R1 CBL INS EIF4EBP1 INSR MAP3K10 EIF4E MAPK4 MTOR MAP3K11 RPS6KB1 EXOC7 HEL-S-31 MAP3K14 GSK3B MAPK8 MAP3K7 GSK3A PRKAA2 MAPK7 IRS4 CYP2B6 MAP3K13 RXRA FLOT1 CYP7A1 FLOT2 RPS6KB2 ABCG8 ABCG5 MAPK6 PTPN1 HEL-S-42 MAPK11 MAPK9 RICTOR DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260410%WP5053%HOMO SAPIENS Development of ureteric derived collecting system BMP2 GDF11 BMPR2 NR1B3 ETV4 SPRY1 SMAD1 DCN PAX2 TGFB1 BMP7 FST SHH CCND1 RARA SMO SIX1 HOXD11 CELSR1 HOXA11 GRIP1 SALL1 BMPER GLI3 SIX2 GPC3 GDNF EYA1 CRIM1 ETV5 RARB BMP5 CTDNEP1 FRAS1 ANOS1 FREM1 RET BMP4 FREM2 BMPR1A HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260410%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 FOXE1 HR RBPJ Nbla10317 HOXC12 FOXQ1 TCF3 CASP14 SOSTDC1 KRTAP3-3 PHLDA1 IGFBP5 MSX2 SOX2 KRTAP15-1 SPINK6 KITLG SPINK5 GTPBP4 NOTCH2 FOSB ADAMTS20 DSG1 RUNX3 GAS1 S100A4 DSG4 GPRC5D DSC2 ZBTB16 GPR49 DLX3 SMAD1 KLK5 KLK4 KLK6 LRIG1 PERP KRTAP6-1 KRTAP2-4 MSX1 ELANE GSDMA TP63 KRTAP8-1 NFATC1 DKK3 KLK13 KLK14 FOXN1 KRT19 GJB6 CD200 ATL1 IGF1 SMAD4 ADAM17 DKK4 BMP4 TCF4 EGFR CD133 FOS DKK1 JUN SFRP1 NFKB1 CTGF GATA3 NR3C1 EGR2 FST WIF1 CD34 FZD1 BMP6 CTNNB1 SOX9 NOTCH1 IFNG LEF1 BMPR1A CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260410%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P CMA1 CTSG REN SPINA BIFIDA%WIKIPATHWAYS_20260410%WP5150%HOMO SAPIENS Spina bifida SHMT1 MTRR MTR AHCYL2 MAT1A MTHFD1 DNMT3B ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260410%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma NR3C1 PLCB3 PLCB1 PLCB2 MYL4 MYL1 ADCY1 MYL2 ADCY8 MYL3 ADCY6 ADCY3 PRKAR1B PRKAR1A ADCY9 GNAS CREB1 ADRB2 PLCB4 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260410%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PIK3R4 PLA2G6 SPTLC1 ATG3 ATG10 ATG14 ATG12 MAP1LC3A ATG16L1 PRKAA1 TSC1 MTOR RHEB ULK1 ACACA STK11 DEPTOR RB1CC1 ATG101 PANK2 WIPI2 WDR45 TSC2 DCAF17 WIPI1 C19orf12 RPTOR CP COASY FA2H MLST8 ATG2A FTL AKT1S1 ATG5 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP23%HOMO SAPIENS B cell receptor signaling CRK MYC PIK3R2 NFATC2 PIK3R1 NCK1 CBL STM7 BLK CD79A CDC42 FYN INPP5D PLCG2 PIP5K1A MAPK4 PTPN11 PLCG1 PTPRC PIP5K1C REL PTPN6 LYN RPS6KA1 PDPK1 GSK3B MAPK8 SYK CD81 CHUK BLNK BCL6 GTF2I MAP3K7 CR2 MAP4K1 LAT2 BTK HCLS1 NFKBIA CARD11 GSK3A DAPP1 VAV2 BCL10 CD19 PTPN18 NFATC3 TEC TIEG2 CD79B PIK3AP1 CD22 ATF2 FOXO1 IKBKB IKBKG MAPK1 HRAS MAP2K6 JUN MAP2K1 MAP2K2 BRAF NFKB1 MAPK14 GRB2 SOS1 RAF1 RASGRP3 CRKL PRKCB RAC1 RELA MAX MAPK9 GAB2 VAV1 CAMK2A CREB1 LCK RAPGEF1 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260410%WP3298%HOMO SAPIENS Melatonin metabolism and effects CYP1B1 ACHE ADRB1 AANAT APOE MTNR1A FOXO1 CYP2C19 EDN1 CYP1A1 MAP2 SIRT1 CSNK1E ASMT CRY1 NFKB1 PER2 PER1 CALM1 SULT1A1 CRY2 GSK3B ECE1 PRKCA IRAK1 CSNK1D PER3 MTNR1B CAMK2A MAOA TRAF6 ADIPOGENESIS%WIKIPATHWAYS_20260410%WP236%HOMO SAPIENS Adipogenesis NR1H3 NR1C1 DDIT3 SCD WWTR1 IGF1 RBL2 MIF UCP1 FRZB HMGA1 HNF1A CDKN1A MEF2B BMP4 LPL BMP2 AHR RBL1 BSCL2 FOXO1 NCOR2 KLF6 MEF2D SLC2A4 IL6 IRS1 PCK1 GH1 NAMPT MEF2C GATA2 CREB1 SOCS3 SOCS1 INS STAT1 SP1 STAT2 STAT3 NCOR1 CEBPA CEBPB MIXL1 TGFB1 LEP PPARG RB1 PPARGC1A TNF MBNL1 LMNA LIF GADD45B GADD45A ZMPSTE24 FAS LIPE ID3 CNTFR CISD1 IRS4 GTF3A PRLR ADFP TRIB3 CFD NCOA1 NDN PLIN1 WNT5B NR2F1 BMP3 CYP26A1 TWIST1 BMP1 CELF1 CYP26B1 PTGIS ASIP RETN RXRA SPOCK1 RXRG E2F4 GDF10 SFRP4 KLF7 PNPLA3 CEBPD RORA GATA3 NR3C1 EGR2 KLF15 GATA4 KLF5 DVL1 RARA NR1C2 WNT1 FOXC2 FZD1 CTNNB1 WNT10B IL6ST HIF1A STAT5B LPIN1 LPIN2 OSM LPIN3 PCK2 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2276%HOMO SAPIENS Glial cell differentiation MBP CNP GAP43 FREP1 HEL70 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260410%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 EGFR PTEN IGF1 GATA4 SPP1 HEL-S-44 STAT3 KDR CD81 EGF IL6 HEL-S-102 CD63 ETS2 BIRC5 RETINOL METABOLISM%WIKIPATHWAYS_20260410%WP5188%HOMO SAPIENS Retinol metabolism DHRS4 SDR16C5 CYP2W1 DHRS9 HEL-S-53e AWAT2 RPE65 PNPLA4 AOX1 BCO1 RDH12 CYP1A1 LRAT CYP3A7 CYP2A6 ADH1A ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP138%HOMO SAPIENS Androgen receptor signaling PTEN PIK3R2 ROCK1 PIK3R1 CDC42 ARHA SP1 STAT3 NCOR1 LIMK2 SMARCE1 CARM1 HDAC1 RB1 GSK3B FLNA CCND1 SIN3A SMAD4 FHL2 KAT5 ROCK2 EGFR RHOB EP300 SMIM40 NCOR2 FOXO1 PAK6 NCOA1 RAD9A SIRT1 RAN CCNE1 RUNX2 JUN MDM2 SUMO1 CREBBP UBE2I BRCA1 TGFB1I1 UBE3A EFCAB6 ZMIZ1 HEL32 KAT7 KDM1A TGIF1 PIAS2 TLE5 CTNNB1 KAT2B ZNF318 RAC1 FKBP4 SRC RNF6 HEL-S-99n RNF4 RELA HEL-S-67p PSMC3IP ETV5 BAG1 PATZ1 PIAS1 NR0B2 NR2C2 STUB1 CREB1 RLN1 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260410%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NRXN1 GRIN3A GRIA2 DLG4 NLGN1 GRIN1 GRIA3 GRIA4 GRIN2B NLGN3 GRIN3B NLGN2 NEUROINFLAMMATION%WIKIPATHWAYS_20260410%WP4919%HOMO SAPIENS Neuroinflammation NOS2 ASCC1 TLR4 FOS MTOR CHUK RELA JUN NFKBIA MAPK8 COX2 MAPK14 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260410%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT2B1 PAPSS1 SULT1C3 SULT1A1 SULT1C2 SULT1B1 SULT6B1 SULT1A4 SULT1A2 SULT1C4 HEL-75 SULT1E1 PAPSS2 SULT2A1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260410%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS RAB5A BCL2 SMIM40 TOMM40 BAD DERL1 PPP3CC CCS MAP3K5 HEL-S-44 MAP2K6 BAX PPP3CA BCL2L1 MAP2K2 MAPK14 TNFRSF1A TNF CASP9 CASP12 GPX1 HEL-S-2 CASP3 RAC1 SLC1A2 NEF3 NEFL NEFH APAF1 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260410%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways VHL MAP2K5 PTEN KDM5C BHLHE41 ALDOB EFCAB3 HK3 PLOD2 ENO2 KDR STAT3 ENO3 PGM2 MTOR ENPP3 HK2 PBRM1 RAPGEF5 KCNJ2 SDSL PGBD5 LDHD FLT1 FASN SSPN ACACB ACACA ACLY BAP1 HEL-S-32 SETD2 HEL-S-30 PSPH HEL-S-133P PFKP SHMT1 AKT1S1 KSR1 EGFR CAMK1 EP300 SQSTM1 PHGDH HEL-S-51e TSC1 RHEB PSAT1 CEP290 CREBBP PFKL DEPTOR ME1 PDGFRA TSC2 RPTOR GRB10 LDHB MLST8 HIF1A HEL-S-87p PKLR ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 VEGFA RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260410%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2G AGTR2 CAMK1 ATF2 CMA1 CTSG HSD3B1 STAR ATF6B ITPR2 CAMK1D CAMK1G CALM1 ATF4 PLCB2 AGTR1 CREB3L3 CREB3L4 CREB3L2 CAMK4 CALML6 CYP11A1 REN CALML3 HSD3B2 CALML4 CREB3 CAMK2D CREB5 CYP11B2 CAMK2A CYP21A2 CREB1 ATF1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome HBEGF SDCBP CD151 HLA-DMB ITGB1 HLA-DRA CD63 LGALS3BP IGSF8 CD82 SPPL2C PRDM11 ACCS HLA-DMA CRY2 PHF21A ALKBH3 C11orf96 ALX4 TIMP1 TP53I11 SHH LARGE2 PEX16 CHST6 ITGA4 IZUMO1 SLC35C1 SYT13 NRXN1 MAPK8IP1 VANGL1 FREY1 SLC25A17 B4GAT1 GLI3 B3GNT7 PEX3 TSPAN18 LEF1 MS4A1 EXT1 B4GALT4 EXT2 ITGA6 CHST1 CD19 REST PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260410%WP4917%HOMO SAPIENS Proximal tubule transport SLC6A20 SLC4A4 SLC5A5 CLTRN CA4 ATP6V0A4 SLC3A2 ATP6V1E1 ATP6V1D SLC22A11 ABCG2 ATP6V1G1 SLC6A19 ATP6V0B SLC6A18 SLC36A2 SLC34A1 ATP1B1 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 SLC34A3 ATP6V0E1 ATP6V0C SLC22A7 ATP6V1B1 SLC22A2 SLC2A2 SLC5A1 ABCC2 ABCB1 AQP1 SLC16A10 ATP6V1F SLC1A1 SLC47A2 ATP6V1A SLC9A3 SLC22A6 SLC47A1 SLC3A1 ATP1A1 SLC5A2 ATP6V1C1 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260410%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB RXRA RXRG RARB RARA NR1B3 IL11 SIGNALING%WIKIPATHWAYS_20260410%WP2332%HOMO SAPIENS IL11 signaling PIK3R2 PIK3R1 BCL2 SOCS3 IKBKB FYN STAT1 MAPK1 STAT3 PTPN11 HRAS MAPK3 RPS6KB1 IL11RA RUNX2 PTPA MAP2K1 MAP2K2 BIRC5 TGFB1 IBSP BGLAP FES GRB2 RPS6KA1 PDPK1 RAF1 ITGA2 IL6ST SRC JAK1 CHUK RELA IL11 RPS6 TYK2 PIAS1 CREB1 YES1 ATF1 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation GABARAPL1 RB1 RB1CC1 TNF ATG101 GABARAP ATG16L1 MAP3K5 TRAF2 PTK2B WDR45B ULK1 GABARAPL2 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260410%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway NR3A2 HSD17B1 HSD17B2 SULT1E1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 SLCO4C1 SLCO1B1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260410%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 LEP CPT1A ADIPOR2 PRKAB1 PRKAG1 ACACA LEPR ADIPOR1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260410%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260410%WP3645%HOMO SAPIENS NAD biosynthetic pathways TNKS SIRT4 SIRT5 SIRT7 TDO2 SIRT2 SIRT3 NMNAT1 TNKS2 NAPRT PARP2 NAMPT PARP4 SIRT1 BST1 SIRT6 NADSYN1 PARP1 IDO1 HEL-S-90n RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260410%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway MMP2 CRK MYC PIK3R1 NCK1 BAD EIF4EBP1 MSH2 STAT3 PTPN11 ITGB1 PIK3CA BIRC5 CASP9 RAD51 MAPK8 PAK1 CHUK NFKBIA MAPK13 ERBB2 EGFR YAP1 GRB14 FOXO1 IKBKB IKBKG NRAS NOS2 MAPK1 ANGPT4 HRAS ANGPT2 MAPK3 ANGPT1 BAX NFKB1 MAPK14 MAPK12 GRB2 KRAS SOS1 RS1 GRB7 TNIP2 TNIP3 MAPK11 CTNNB1 RAC1 SRC PXN RELA MAPK9 STAT5B OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260410%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies BMP2 HES5 SMAD2 CSNK1A1L ZMPSTE24 FNTA ICMT CDK4 DICER1 TARBP2 CEBPA EMD HMGA2 CEBPB RUNX2 AGO2 CEBPD CREBBP GDF8 TGFB1 CTSK HDAC1 PPARG RB1 TNFRSF11B MYOD1 GSK3B SPP1 JUNB LEMD3 CTNNB1 PS1TP5BP1 WNT10B KAT2B TCF7L2 LMNA TCF7L1 CDKN1A NOTCH1 LEF1 CSNK1A1 AXIN1 WNT7B MAOA HES1 APC GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260410%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260410%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection NFATC2 NCK1 CBL FYN IL5 CDK4 CD40LG MAP3K8 CTLA4 PLCG1 PTPRC PTPN6 PIK3CA MAP3K14 GSK3B TNF PAK1 ITK CHUK PRKCQ LAT MAP3K7 IL10 NFKBIA CARD11 BCL10 IKBKB IKBKG RRAS FOS MAPK3 CD3D JUN PDCD1 MAP2K1 MAP2K2 NFKB1 CALM1 CSF2 GRB2 SOS1 RAF1 IL2 IL4 GRAP2 DAG1 CHP1 AHSA1 CD8A LCP2 ICOS IFNG MAPK9 ZAP70 LCK BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260410%WP272%HOMO SAPIENS Blood clotting cascade PLG SERPINB2 PLAT FGA HEL-S-78p F9 F11 F10 SERPINF2 F2 F3 F5 F7 F8 F13B KLNA1 KLKB1 VWF MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260410%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome HNRNPH1 GPRIN1 TET3 PTEN DLX5 BDNF DLX6 FOXG1 NREP EZH2 FUT8 PRPF38A FUS GAD1 OPRK1 POU4F1 HNRNPF TARDBP TAF1 POU3F2 SP1 NCOR1 MTOR SST IGF1R HDAC1 IGF2 IGF1 CTCF YBX1 SIN3A BCL6 CNP TET2 TET1 GRIA3 GRIA4 SP3 REST FGF7A FKBP5 NF1 MBP FGF5C GRIN1 APOC2 FGF2 SGK1 CEBPD HEL-S-20 SMC3 UBE3A MEF2C RPS6 PSIP1 CAMK2A CDON RBFOX1 CREB1 TAP1 MYT1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260410%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 UCP2 CPT2 SLC25A20 ACAT1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5365%HOMO SAPIENS 4p16 3 copy number variation FGFR3 PIK3R1 CBL NELFCD MAPK1 SLBP NSD2 PLCG1 CLTCL1 MAPK3 FAM53A NELFB NELFA CKAP5 LETM1 NICOL1 FGF2 TACC3 NAT8L GRB2 SOS1 POLN UBE2J2 FRS2 ERI1 H3F3B PPAR SIGNALING%WIKIPATHWAYS_20260410%WP3942%HOMO SAPIENS PPAR signaling LPL ANGPTL4 SLC27A1 DBI CD36 EHHADH ACSL1 PLIN1 UBC FABP1 NR1H3 NR1C1 FABP4 RXRB RXRA RXRG CYP7A1 SCD PLTP AQP7 SLC27A4 OLR1 ACOX1 HEL-S-28 APOA2 APOC3 APOA5 PPARG PDPK1 ME1 FADS2 NR1C2 PCK1 CPT1C CYP8B1 CYP27A1 UCP1 CYP4A11 SLC27A5 CPT2 PCK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260410%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex NRF CD8B1 PRG3 CD2 MMP25 IGLL1 CXCL8 LBP FYN CD8A CD3G CD3E IL6 HLA-DRB5 HLA-DRA HLA-DRB1 CRP ZAP70 LCK TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260410%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NQO1 MAF KEAP1 AIMP2 GCLC HMOX1 MAPK8 GCLM EPHB2 PRKCA CEBPB NFE2L2 SLC7A11 PIK3CA CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260410%WP2023%HOMO SAPIENS Cell differentiation expanded index KLF4 PAX7 MYOD1 EZH2 HDAC5 LEFTY1 SOX2 TLX3 ID2 TLX2 TLX1 MEF2D LEFTY2 STAT3 MEF2C MEF2B RUNX2 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260410%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BOK MCL1 MYC BCL2 BCL2A1 GSK3B BCL2L12 BCL2L10 BCL2L2 BCL2L14 AKT3 BAK1 BAX ITGA6 ITGB4 PTHLH BCL2L1 GSK3A BCL2L13 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260410%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome CCDC6 PTEN TBX6 EZR PCNA SIAH1 REL PPARG SMEK1 DOC2A FAM57B FIMP CASP8 CCT6B SPN TRAF2 PPP4R1 PPP4R2 PPP2R1A PPP4R4 PAGR1 UNC13B UNC13A HEL-S-69 PPP2R5D PPP4R3B ASPHD1 TCP1 PPP2CA KCTD13 TRAF6 ZG16 INO80E HDAC3 MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT7 CCT4 IGBP1 MLL2 HEL-S-100n C16orf54 CCT6A TAOK2 YPEL3 MAP2K6 MAPK3 MAP2K3 NFKB1 CDIPT HEL-S-90n NR3C1 PAXIP1 BPTF PARP4 HEL-S-87p KMT2C PRRT2 HEL70 G PROTEIN SIGNALING%WIKIPATHWAYS_20260410%WP35%HOMO SAPIENS G protein signaling PRKCZ PPP3CC ARHA PRKACG PRKAR1B PRKAR1A ADCY9 PDE4B PDE4A GNG10 GNG12 PDE4D GNG11 GNG13 GNAI3 GNB2 ADCY3 GNAI1 GNB3 GNB5 GNA13 GNGT1 PRKCQ GNAO1 GNGT2 GNB1 GNAS PRKD1 ADCY1 ADCY8 ADCY6 GNG3 GNG5 GNG4 NRAS RRAS GNG7 HEL159 AKAP10 ARHGEF1 GNG8 AKAP12 AKAP11 HRAS PDE8A PRKD3 AKAP9 GNAZ PDE1C PPP3CA PDE1B PDE1A AKAP7 AKAP6 AKAP5 AKAP4 GNA14 GNA15 PLCB3 AKAP8 KCNJ3 CALM1 GNAL PDE7B KRAS PDE7A PRKCH PRKCB PRKCE PRKCA PRKCI GNA11 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260410%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1CC BCL2 EIF2AK2 MAP1LC3A PPP1R14C PPP1R3A XBP1 ERN1 DDIT3 PPP1R14A HEL-S-80p PPP1R12B ATF4 PPP1R3C PPP1R12C PPP1R15A PPP1R7 PPP1R15B PPP1R13B PPP1R11 PPP1R10 PPP1R1B PPP1R9A HEL-S-89n PPP1R2 PPP1R8 MAPK8 PPP1R16B MBTPS1 PPP1R14B EIF2AK1 PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3B PPP1R3E PPP1R1C PPP1R3D PPP1R14D MBTPS2 EIF2S1 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260410%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 ATF4 CREB3L3 CD14 CREB3L4 CCL2 MAPK11 CREB3L2 IL1B CREB3 RELA NFKB2 IL6 REL IL10 RELB CREB5 NFKB1 CREB1 MAPK14 MAPK13 MAPK12 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260410%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CAMK2G BCL2 CYCS BAD NOS2 DLG4 AKAP9 CNGA1 GUCY1A2 GUCY1B1 GRIN1 PBR PDE3A ACTN2 NFKB1 CALM1 TNF CASP9 IL1B CNGB1 RELA IFNG NEFL CAMK2D NFKBIA CAMK2A CNGA3 CNGA4 NPPB PDE2A GRIN2B CREB1 CNGB3 NPPA PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260410%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260410%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling HTR2B MAPKAPK2 KRAS RAF1 GATA4 HTR2A NRAS MAPK1 HRAS MAPK3 RASGRF1 MAP2K1 MAP2K2 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies FCER1A MS4A2 CRLF2 IL13RA1 IL2RG TSLP IL4 JAK3 IL5 FCER1G IL13 STAT3 OSMR IL25 TYK2 IL33 IL1RL1 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260410%WP3871%HOMO SAPIENS Valproic acid pathway IVD HADHB ABAT HDAC1 CYP2C9 EHHADH CYP2B6 HSD17B10 ACADSB CYP2A6 FERROPTOSIS%WIKIPATHWAYS_20260410%WP4313%HOMO SAPIENS Ferroptosis BACH1 STEAP3 TFRC SLC40A1 SAT2 CBS FTH1 SLC39A8 SLC11A2 SLC39A14 VDAC3 CHMP6 CTH CHMP5 IREB2 DPP4 FTMT PCBP1 LPCAT3 HMGCR MAP1LC3C FACL4 TF GCLM SLC38A1 CP CYBB FTL PHKG2 HEL-S-102 AKR1C1 ATG5 AKR1C2 SLC7A11 AIFM2 POR DKFZp762B153 SLC3A2 NOX4 CISD1 ACSL3 MAP1LC3A HMOX1 GCLC ACSL1 ACSL6 COQ2 ACSL5 ALOX15 PRNP GPX4 HEL-S-64p FDFT1 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260410%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP2 MMP9 SMAD2 HEL-S-78p PRKAA1 MCUB MCU SCX ATP2A1 TOMM20 SLN SGCA TRPC6 CAPN3 SSPN TRDN CACNB1 ITPR2 STIM1 PPIF ORAI1 CASQ1 ELANE SLC25A5 TGFB1 CACNA1F CACNG1 PRG3 CACNA1S SNTB1 SIGMAR1 FKBP1A TNF CASP9 CACNA2D1 CYBB SMAD4 IL10 TGFBR1 NFKBIA TGFBR2 IL1A TRPC3 PRKAA2 MPO PLA2G2A NOX4 NOS2 TRPC1 TNNI1 IL6 DMD RYR1 NFKB1 CTGF AGTR1 SPP1 FGA DAG1 IL1B CAMK2D KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260410%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway CSF2 GRB2 KIR2DL1 KIR2DL3 TNF FYN CD34 SYK PRKCA TYROBP LCP2 RAC1 HRAS PRKCQ PLCG1 LAT HLA-C IFNG PTPN6 VAV1 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260410%WP4963%HOMO SAPIENS p53 transcriptional gene network IRF9 BBC3 PTEN TIGAR PCNA MSH2 PRKAA1 MTOR PRKAB2 PRKAB1 TNFRSF10B TP53AIP1 ADORA2B ULK2 ULK1 ZMAT3 TRAF4 PERP SESN1 SESN2 DDIT4 SMR3B ACAD11 NCF2 TNF SERPINB5 SCO2 ADGRB1 PML PRKAG1 XPC PRKAG2 CPT1C AURKA DRAM1 E2F7 RPRM SIVA1 PRKAG3 TP53INP1 MGMT XRCC5 CX3CL1 FUCA1 FANCC TNFRSF10D CDKN1A TP53I3 ULBP2 BTG2 AKT1S1 ULBP1 LIF APAF1 SLC7A11 RRM2B PRKAA2 TNFSF6 ISG15 GADD45A FAS CCNG1 SFN CCL2 CCNE1 THBS1 BAX CDK2 DEPTOR PMAIP1 TSC2 GPX1 RPTOR POLK MLST8 GLS2 PIDD1 NOTCH1 DDB2 ERCC5 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis UGT1A10 HSD11B1 UGT2B7 HSD11B2 SRD5A2 CYP11B2 CYP21A2 AKR1C1 AKR1C2 AKR1C4 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260410%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain AMOT MAP2K5 RAF1 YAP1 TRIO ARHA MAPK1 MTOR RAC1 MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP2K1 MAP2K2 NFKB1 PIK3CA SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260410%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL17 IFNAR1 ACE2 MAVS CXCL12 CXCL6 RIGI CXCL13 STAT1 STAT2 TRIM25 IL8RB TRAF5 CXCL1 TGFB1 CXCL5 HDAC2 PPBP TNF CXCL11 TRADD CASP8 CXCL9 TBK1 TRAF2 CXCL3 IFNB1 FADD TP53I3 IFITM1 IL10 CXCL2 IFIT2 AP1G1 DHX58 IRF3 HAVCR2 TRAF3 TLR7 LAG3 TRAF6 hEMMPRIN IRF7 TANK NUP98 CD160 LARP1 RAE1 MX1 EP300 CXCL8 CCL5 CCL4 CCL2 CCL3 IL6 NFKB1 IL6R PF4 RIPK1 CSF2 TFAP2A JAK1 IFNAR2 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260410%WP1471%HOMO SAPIENS Target of rapamycin signaling PRKAA2 MAPKAP1 RRAGA DDIT4L RRAGB RRAGD CDC42 EIF4EBP1 PRKAA1 TSC1 MTOR PRKAB2 RPS6KB1 HMGCR PRKAB1 RHEB ULK2 ULK1 DDIT4 FKBP1A TSC2 PRKAG1 PRKAG2 IDI1 RPTOR PRKCA PRKAG3 MLST8 RAC1 AKT1S1 RICTOR PRR5 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260410%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BBC3 MCL1 BLK BAD BCL2L11 TNFRSF10A TNFRSF10B BIRC5 IL1R1 BIRC7 BIRC2 MAP3K14 BIRC3 BCL2A1 BCL2L10 TRADD BCL2L2 CASP9 MAPK8 CASP8 CASP6 IL1R2 CASP10 IRAK1 CASP3 TNFRSF10D FADD SEPTIN4 DFFB NFKBIA DFFA MADD PRKD1 APAF1 TRAF3 AIFM2 TRAF6 TNFSF6 MYD88 HRK BCL2 TNFRSF6B FAS CAPNS1 CYCS CASP4 SMIM40 PTRH2 TNFRSF25 IKBKB TNFRSF1B NAIP BAG3 BMF BAK1 MAP3K5 BIK TNFRSF10C PTPN13 FOS CDKN2A MAPK3 BNIP3 BAX JUN BCL2L1 NFKB1 TNFRSF1A AIFM1 TNFSF10 CASP2 BOK RIPK1 PMAIP1 PIDD1 DIABLO CRADD HTRA2 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260410%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PTPN11 CTLA4 PIK3R2 CD80 PIK3R1 PTPN6 PIK3R3 HLA-DRB1 PPP2CA PIK3CD PIK3CA GPCRS OTHER%WIKIPATHWAYS_20260410%WP117%HOMO SAPIENS GPCRs other CHRM3 OR2F1 GPR55 EMR3 ADGRD1 GPR143 OR2A5 LGR6 CHRM2 OR2A4 ADGRL2 GPR18 F2R HTR1F ADGRL3 OR7E24 IL8RB CCR5 SMO HTR2A CXCR1 SSTR2 EDNRA FSHR CCR2 UTS2R CNR1 CCKBR CXCR3 OR1G1 OR2M4 GPR61 GPR62 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 GPR176 HTR7 GPR132 ADORA2A ADRA1D GNRHR GPR135 ADGRV1 ADRB2 S1PR1 ALG6 OR1F1 OR2H1 TAAR5 GPR183 OR1J2 TAAR2 OR1N1 GPR162 OR5AC2 ADGRF5 VN1R1 OR10A2 OR6C3 DRD3 OR3A3 OR6C2 DRD4 OR10A5 OR3A1 OR8G1 CELSR1 PTGFR OR1E1 C5AR2 GPR88 GPR83 GPR84 MCHR2 GHRHR FY OR2B6 NTSR1 OR5D3 P2RY13 GPR17 P2RY11 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260410%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CBFB ELOC RBX1 UBA3 NAE1 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260410%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling CD8B1 CALM1 PTEN NFATC2 GSK3B IL2 FYN DYRK2 ITK DYRK1A PRKCA CD8A CTLA4 PLCG1 PTPN6 CSNK1A1 PPP3CA PDCD1 NFKBIA GSK3A ZAP70 NFKB1 LCK SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260410%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD NKX2-5 MEF2C KLF4 CAMK2D MEF2B CCND2 MEF2D LEPTIN SIGNALING%WIKIPATHWAYS_20260410%WP2034%HOMO SAPIENS Leptin signaling PTEN PIK3R2 ROCK1 PIK3R1 SOCS3 BAD CDC42 EIF4EBP1 FYN EIF4E PLCG2 STAT1 ARHA SP1 PRKAA1 STAT3 CFL2 PTPN11 KPNA4 MTOR KHDRBS1 PLCG1 SOCS2 RPS6KB1 CISH SOCS7 REL PDE3B ACACB ACACA LEP RPS6KA1 GSK3B MAPK8 CHUK GSK3A ERBB2 PRKAA2 ROCK2 SH2B1 FOXO1 IKBKB IKBKG NCOA1 MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 LEPR NFKB1 MAPK14 PTPN1 GRB2 SOS1 RAF1 IRS1 RAC1 SRC JAK1 RELA RPS6 STAT5B CREB1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3R4 MAPKAP1 PIK3R2 PIK3C2G PIK3R1 PIK3C2A PIK3C2B FOXO1 IKBKG TSC1 MTOR SIRT1 PHLPP1 PIK3R3 PIK3R5 STK11 PIK3CA ATM GSK3B PARP2 TSC2 AKT3 PIK3CD RPTOR PARP3 MLST8 RICTOR PARP1 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260410%WP325%HOMO SAPIENS Triacylglyceride synthesis DGAT1 LPL PLPP2 PLPP1 DGAT2 LIPE GPAM PNPLA2 GNPAT GPD1 AGPAT5 AGPS MOGAT3 MOGAT2 LIPC MOGAT1 AGPAT3 AGPAT4 LIPF PLPP3 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260410%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CCDC6 CDK6 MYC BARD1 CDC2 CDC25B PCNA MSH6 SAP30 CDK4 PRMT2 HMGB1 TOP2A ORC1L CCND3 HMGB2 SMC2 HDAC1 RB1 TFDP1 TFDP2 PRKDC E2F2 FAF1 TTK E2F3 NPAT CCNB2 CCND1 HLTF RBBP7 SIN3A RBP1 PLK4 CDT1 FANCG POLA1 ZNF655 RRM2 MCM7 CDKN1A SKP2 MAPK13 RRM1 DHFR RBBP4 RPA3 CHEK1 MCM3 RPA1 MCM6 TYMS CCNE1 CDK2 MDM2 PRIM1 CCNE2 CDC45 RAF1 SMC3 POLD3 SMC1A CDKN1B POLE SUV39H1 RFC3 RFC4 CCNA2 CCNB1 H2AZ1 POLE2 WEE1 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260410%WP4925%HOMO SAPIENS Unfolded protein response CASP2 BBC3 ATF4 PPP1R15A BCL2 PMAIP1 HEL-S-89n MBTPS1 XBP1 RTCB BCL2L11 TXNIP IL1B ERN1 TNFRSF10B DDIT3 MBTPS2 NFE2L2 EIF2S1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260410%WP404%HOMO SAPIENS Nucleotide metabolism RRM2B HPRT1 DHFR POLG POLA1 RRM2 ADSL NME2 OAZ1 SRM IMPDH1 ADSS MTHFD2 RRM1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5136%HOMO SAPIENS ALA oxylipin metabolism EPHX2 ALOX5 ALOX15 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260410%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFB9 ECSIT NDUFA12 TMEM186 C3orf60 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 ND1 NDUFS1 TMEM126B ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 DMAC1 NDUFB10 NDUFB6 NDUFB5 NDUFB11 DMAC2 NDUFB4 NDUFB3 NDUFB2 NDUFB1 TMEM70 NDUFV3 NDUFV2 NDUFA7 TIMMDC1 COA1 NDUFA6 ZNF183 NUBPL NDUFA3 NDUFA2 ND4L NDUFAF6 NDUFA5 NDUFAF4 NDUFAB1 ACAD9 NDUFA13 NDUFAF2 NDUFAF1 NDUFA10 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260410%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CALCA IL3 BHLHE41 MTOR CTF1 SMAD1 ULK1 NR1D2 SMAD9 TGFB1 HMGB1 NFATC1 LEP DKFZp781O1323 RB1CC1 IGF1 NPAS2 EFNB2 SMAD4 TNFRSF11A ATG5 TRAF6 BMP4 BMP2 PRKAA2 DKFZp762B153 ATG3 SQSTM1 BCL2 BHLHB2 ATG10 AMBRA1 BMPR2 ATG12 MAP1LC3A SOST CTHRC1 ATG16L1 BMP3 SEMA3A IL6 WNT16 DKK1 RUNX2 CRY1 LRP5 PER1 CTSK PTH CSF1 RORB TNFSF11 ARHGAP4 TNFRSF11B FYCO1 LAMP2 VCP ATG101 DRAM2 SEMA4D PLEKHM1 SP7 BMP6 WNT10B NOTCH1 BMP5 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260410%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome FEZ2 SNURF NUP54 CDK6 NUP58 DLX5 BDNF OCA2 NUP205 SLC45A2 MAGEL2 CDKN2B SEH1L PRKCZ LHB INS ATP10A AAAS NUP160 NHLH2 EIF4E NUP42 MDM4 NUP85 CDK4 RANBP2 CDKN2C NUP155 TPR NUP153 CDC6 NUP35 MKRN3 GNRH1 CYFIP1 FMR1 NUP88 TUBGCP5 NIPA1 MSX1 TUBGCP6 GABRB3 POM121 TUBGCP4 NIPA2 RB1 CCND1 GABRA5 OXT GABRG3 GABRG2 GABRG1 CGA KISS1 NGF HEL-S-71 GHRH GHRL TYR NUP98 RAE1 NUP133 PCSK1 CCND2 POMC NDN HERC2 CDKN2A MDM2 BBS4 RNF8 UBE3A AHCTF1 NUP107 NUP188 NPAP1 GABRR3 PCM1 GABRR1 NUP62 NUP214 NDC1 GOLGA8S SNRPN NUP210 FSHB GOLGA6L2 TACR3 NUP93 FEZ1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260410%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CCL11 BDNF DBI TNF CCL5 TREM2 CCL2 TREM1 CHI3L1 CX3CL1 IL1B IL6 GRN NEFL ADM PBR S100B CRP CCL23 GFAP OLR1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260410%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex CDK8 MED1 TAF1 MED15 NELFB NELFA GTF2B MED19 MED14 CCNC MED16 TAF5 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED9 MED4 GTF2F1 MED27 MED26 MED6 MED29 MED28 MED23 MED22 MED25 MED24 MED21 GTF2A1 CTDP1 TAF9 GTF2E2 POLR2A THRA MED30 POLR2B MED31 POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2M TAF12 TAF13 TAF10 TAF11 TRFP TAF8 NELFCD TAF7 TAF6 CRSP9 TAF4 TAF3 POLR2C TBP METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260410%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway TXN MTR MAT1A AMD1 APIP MRI1 IL4I1 MSRA MTAP ADI1 SMS SRM MSRB2 MSRB3 ENOPH1 HEL-S-61p CHDH DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260410%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens SESN2 ATF4 MYC FOXO1 TSC2 IRS1 PHB2 TSC1 SLC7A7 MTOR MARS1 GDF15 OMA1 HSPD1 CLPP LONP1 LONP2 EIF2A PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP4784%HOMO SAPIENS Proteoglycan biosynthesis SLC35B2 XYLT2 CANT1 SLC26A2 BPNT2 B3GALT6 XYLT1 CHSY1 CHST14 CSGALNACT1 B3GAT3 PAPSS2 EXT1 EXT2 CHST3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260410%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 TLR4 MYD88 IKBKB IKBKG MAPK1 NFKB2 REL NFKB1 TICAM2 TLR3 TBK1 IRAK1 IKBKE CHUK RELA IRAK4 TICAM1 TLR1 RELB TIRAP TLR9 TLR8 IRF3 TRAF3 TLR7 TRAF6 IRF7 TLR5 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260410%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A8 SLC39A14 MT1M SLC30A10 MT2A SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 SLC39A11 SLC39A10 SLC39A13 SLC30A1 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260410%WP1533%HOMO SAPIENS Vitamin B12 metabolism PLG MCEE SCARB1 MPO CBS APOE APOB INS LDLR CCL5 ABCA1 HEL-S-78p CCL2 INSR HEL-S-51e CTH HEL-S-44 ALB SAA1 SAA2 NFKB2 IL6 CUBN CRP NFKB1 SERPINA3 HBB MTRR MTR PLAT TNF MAT1A TCN2 CBLIF FGA TCN1 HBA2 IL1B RELA F2 F7 IFNG SAA4 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260410%WP5399%HOMO SAPIENS NPHP1 deletion syndrome RPGRIP1L NPHP1 MAPK1 MAPK3 FLNA PTK2B FLNB INVS BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260410%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMP2 TOB1 SMURF1 SMAD6 TOB2 SMAD4 SMAD1 NOG RUNX2 BMPR2 BMPR1A ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260410%WP1993%HOMO SAPIENS Angiogenesis overview MMP2 CRK VHL MMP9 MMP14 ROBO4 SHB NCK1 TIMP4 BMX BAD CDC42 PLXND1 KDR PTPN11 MTOR PLCG1 FGFR1 PDPK1 MAPK8 PAK1 FRS2 MAP3K7 APC WAS ATF2 NOX4 NRP1 GRB14 ROBO1 MAPK1 MAP2K6 SEMA3A ANGPT1 MAP2K4 MAP2K1 SLIT2 MAPK14 GRB2 KRAS SOS1 RAF1 GRB7 PIK3CD MAPK11 DAG1 PRKCA RAC1 SRC PXN F2 PTK2B IQGAP1 PLA2G1B VEGFA NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260410%WP288%HOMO SAPIENS Nod like receptor NLR signaling CD40 CHUK RELA MAP3K7 IKBKB ERBIN MAPK8 IKBKG EPHB2 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling CRK MET PTEN RAP1A PTGS2 MAPK1 STAT3 PTPN11 FOS HRAS MAPK3 ITGB1 JUN MAP2K1 MAP2K2 PIK3CA GRB2 DOCK1 SOS1 RAF1 MAPK8 CRKL PAK1 ITGA1 SRC PXN HGF PTK2B MAP4K1 RAPGEF1 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260410%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA RARA NR1i1 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260410%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development BMP7 KLF4 DMP1 DSPP SOST SP7 NOTCH2 NOTCH3 CTNNB1 ALPL HNF1A NOTCH1 DKK1 RUNX2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260410%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult LMO2 HBZ HBA2 HBG2 HBG1 HBB HBE1 HBD tal-1 GATA1 LDB1 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling EGFR TLN1 NRAS MAPK1 HRAS COL1A1 ITGB1 MAP2K1 MAP2K2 MAPK14 MAPK12 MAPK10 GRB2 KRAS SOS1 RAF1 AKT3 PIK3CD MAPK8 MAPK11 AREG ITGA1 SRC PXN MAPK9 MAPK13 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260410%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation PIK3R2 PIK3R1 ARHH SOCS1 DGKA TMEM222 ARIH2 UBASH3A MAP3K8 DGKZ RASA2 RNF7 RPRD1B PLCG1 SH2B3 SH2D1A REL FIBP PTPN6 CD5 AGO1 MAP3K14 PDPK1 TNFAIP3 ITK GNA13 CHUK PRKCQ LAT MAP4K1 NFKBIA CARD11 BCL10 TRAF6 IKBKB IKBKG NDUFB10 MEF2D CD3G CD3E CD3D NFKB1 GRB2 CDKN1B CUL5 GRAP2 CD8A LCP2 RELA VAV1 ZAP70 LCK OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260410%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP4A11 CYP2C9 CYP2C8 PTGS2 ALOX15 EPHX3 ALOX12B CYP2C19 ALOXE3 PTGS1 GPX4 CYP3A4 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260410%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260410%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADL EHHADH ACSL3 ACSL1 CPT2 SLC25A20 CPT1A ACADM PECR FACL4 ACADVL ACSF2 ACADS CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260410%WP530%HOMO SAPIENS Cytokines and inflammatory response IL1A IL3 IL5 IL15 IL13 IL6 HLA-DRA HLA-DRB1 CXCL1 TGFB1 CSF3 CSF2 CSF1 IL2 PDGFA TNF IL4 IL7 IL1B IL12B IFNB1 IL11 IFNG IL10 CXCL2 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260410%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells SMAD2 CALCA BAK1 MAP3K5 MAPK1 MTOR MCU BAX PDE1B PPP3R1 BRAF TNFRSF1A PIK3CA FFAR3 TGFB1 SEC16B HEL-S-41 ACTA2 TRPV5 PTH TNFSF11 RAF1 CASP9 CASP8 CASP3 SMAD4 TGFBR1 APAF1 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation BLM PTEN MYC CDC2 IRF8 IFT27 MAEA PRKAA1 NR1H3 CLUAP1 ARMC8 PARD3 PRKAB1 COPS7A ULK1 G6PC1 CARM1 WWTR1 CRY2 MED9 COPS4 COPS6 IFT22 COPS5 PRKAG2 TNFSF13 PARD6B BCL6 RAB8A YAP1 FOXA1 APP WDR26 JUN CRY1 PPP1R14A NR1H2 RMND5A PER1 MKLN1 GID4 PCK1 RPTOR HES6 PRKCI MLST8 IL1B ETV5 CREB1 RRAGA ROCK1 ARHA STAT3 CFL2 BCL2L11 COPS8 MTOR FOXA2 ITPK1 MAP3K14 BIRC2 FHOD1 PRDM1 FERD3L ALKBH5 RB1CC1 DENR PEMT TNF MIGA1 RNF41 TOM1L2 LLGL1 DRC5 DRC7 HEL-S-133P DRC8 FLII GPR85 CLEC16A GRIP1 SHMT1 PLD6 RAI1 RAB39B DRC1 CLTC GDI2 CLTB WDR41 CLTA ATPAF2 ARG2 RMI2 DRC10 TFEB MYH2 TLR4 PARK2 MYD88 TACI SMCR8 C9orf72 GPS1 MIEF2 RASD1 NT5M FNIP1 RANBP9 FNIP2 LIMK1 IFT56 MYO16 RAB10 MYO15A DRG2 TRAF3IP1 IFT172 IFT52 IFT46 FLCN IFT70B RMI1 TOP3A BAX IFT57 NFKB1 IFT20 IFT80 ATG101 IFT25 IFT81 RELA IFT74 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260410%WP129%HOMO SAPIENS Matrix metalloproteinases MMP2 MMP9 MMP14 TIMP4 TCF20 MMP21 MMP20 MMP24 MMP27 MMP26 MMP28 MMP10 MMP11 MMP16 MMP15 MMP17 MMP19 MMP25 TIMP3 MMP23B TNF TIMP1 MMP3 MMP12 MMP7 hEMMPRIN ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260410%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC3 FABP6 ABCC2 ABCB1 SLC10A2 SLC51A SLC51B ABCB11 SLCO1B1 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260410%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 RAB5C RAB5A RAB5B KRAS RAF1 ARAF NRAS RRAS RAB27A MAPK1 HRAS HGS MAPK3 PDCD6IP RRAS2 BRAF EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260410%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC2H1 RHOT1 KIF1B RABAC1 SNCA RAB7A DCTN1 SYPL1 ATAT1 DYNC2I2 CASP8 DYNC1I1 DYNC1H1 MAP2 CASP3 DYNC1LI2 BAX MFN2 RAB3B TRAK1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP2571%HOMO SAPIENS Polycystic kidney disease pathway MYC PLCG2 PRKACG KDR PRKAA1 MTOR PRKAB2 PRKAB1 FLT1 STK11 IGF1R RPS6KA1 GSK3B IGF1 TNF GNAI3 KCNN4 CCND1 PRKAG1 GNAI1 PRKAG2 PRKAG3 SSTR2 WNT3A GNAS SLC12A2 ERBB2 PRKAA2 WNT2B FZD10 ADCY6 IKBKB NRAS WNT5B TSC1 PKD1 FOS HRAS MAPK3 VEGFB EGF WNT16 RHEB JUN CFTR PDE1A SFRP4 MAP2K2 BRAF KRAS DVL1 TSC2 DVL2 DVL3 FZD4 WNT1 WNT3 FZD1 CTNNB1 WNT10B SRC WNT10A WNT9B FZD3 WNT9A FZD2 FZD5 WNT4 WNT8A WNT7B WNT8B FZD7 FZD9 WNT7A GNA11 FZD8 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260410%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity NR1I3 CYP2E1 CYP2C9 CYP2B6 ABCA1 NR1B3 CYP27B1 NR1i1 NR1i2 CYP26A1 CYP24A1 NR1H3 NR1C1 CYP7A1 ABCG5 ABCC3 ABCC2 ABCB1 ABCD3 ABCD2 PPARG ABCB4 CYP4B1 ABCG1 ABCB11 RARA NR1C2 CYP8B1 CYP4A11 NR1H4 RARB CYP3A4 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260410%WP334%HOMO SAPIENS GPCRs class B secretin like CALCRL GLP1R ADGRL2 VIPR2 GIPR GCGR ADGRL3 SCTR GPR64 CRHR1 PTH2R CRHR2 CALCR ADGRE5 ADGRL4 ADGRL1 ADCYAP1R1 GHRHR ADGRE2 PTH1R MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260410%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CTCF CCR2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma NOTUM MYC CSNK1A1L EZH2 CCND3 GSK3B CCND1 WNT3A AXIN1 DKK4 APC ELAVL1 WNT2B CHD8 FZD10 FRAT1 FRAT2 CCND2 SOX17 SOST CER1 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E WNT16 SENP2 DKK1 JUN SOX7 DKK2 SFRP4 SFRP1 SFRP5 PORCN CSNK2B ROR1 LRP5 ROR2 LRP6 CTBP2 CTBP1 NLK CXXC4 KLF4 NKD1 NKD2 WIF1 DVL1 DVL2 DVL3 WNT1 WNT3 FZD1 CTNNB1 WNT10B TCF7L2 MTDH WNT10A FZD3 TCF7L1 FZD2 LEF1 FZD5 WNT4 CSNK1A1 RYK WNT7B FZD7 FZD9 WNT7A FZD8 FOSL1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260410%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation HEL-S-21 ND1 COA3 AS3MT UQCRFS1 SDHA HEL-S-44 ATP1A1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260410%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis 5HT1A FAAH KCNQ2 TRPA1 KCNQ3 PTGS2 CACNA1H PTGS1 TRPV1 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260410%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits VHL TCF7L2 VCAM1 SRC TCF7L1 NOTCH1 LEF1 CXCR4 POSTN TNC CYTIP VEGFA 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ERBB2 COX11 CNNM3 CNNM4 COL2A1 FER1L5 STARD7 CIAO2B SEMA4C ANKRD23 DUSP2 ARID5A ASTL NEURL3 KANSL3 PLXNB2 ZP2 MMS19 SNRNP200 ADRA2B ARHA MAPK1 MAPK3 CIAO2A ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 GLUCURONIDATION%WIKIPATHWAYS_20260410%WP698%HOMO SAPIENS Glucuronidation UGT1A3 UGT1A1 UGT1A10 UGT1A9 UGT2B10 UGT2B11 UGT2B15 UGDH UGT2B17 UGT2B28 UGT1A8 PGM3 UGT1A5 PGM2 UGT2B4 UGT2A2 UGT1A7 PGM5 UGT2A1 UGT2B7 UGT1A4 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260410%WP550%HOMO SAPIENS Biogenic amine synthesis ACHE PAH PNMT AANAT HDC GAD1 ChAT TPH1 GAD2 ASMT DBH DDC TH MAOA PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260410%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGS2 EDN1 ANXA2 PTGER4 PTGER1 PTGER2 PTGER3 PTGIS TBXA2R ANXA6 PTGS1 PTGFRN HEL-S-7 AKR1B1 S100A10 PTGIR ANXA3 ANXA4 SCGB1A1 S100A6 PTGES PPARG HPGD PPARGC1A PPARGC1B CYP11A1 PTGFR SOX9 PTGDR PRL EDNRA EDNRB HSD11B1 HSD11B2 ANXA1 AKR1C1 AKR1C2 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260410%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling PTEN EPOR PIK3C2A PIK3C2B KDR RAB2A ULK1 EPHA2 PDGFD PIK3CA PDGFC NGFR TCL1B PPP2R1B PELO IGF1 HIF3A STRADA PHLPP2 COL11A2 CSHL1 GHB3 PFKFB1 PFKFB4 ITGAE PPP2R5E ITGAX FGF8A PPP2R5B PPP2R5A PPP2R3C CDKN1A PPP2R3A PIK3IP1 PPP2R2C PPP2R2B PPP2R2D PPP2CA RAB8A FGF7B FGF7A ELAVL1 GYS1 KIT FGF18 FGFR3 ATF2 FGF6B FOXO1 IKBKB IKBKG NOS2 TSC1 VEGFB FOXA1 FGF5C VEGFC RHEB VEGFD THBS1 MDM2 FGF2 CSF3 ATF4 FGF7 CSF1 FGF8 EPO RAB14 ITGB3 ITGA2B PDGFRA TSC2 COL4A2 COL4A1 COL4A4 COL4A6 CSF1R EFNA5 EFNA4 FGF20 FGF22 XB EFNA1 EFNA3 FGF14 KITLG EFNA2 FGFR4 FGF13 FGF12 PHLPP1 FGF10 FGFR1 ITGB1 FLT1 ITGB4 ACACA CRTC2 STK11 FLT4 LAMC2 DDIT4 LAMC1 TCL1A PPARGC1A ITGAM ITGAV ITGA4 ITGA2 NGF IFNB1 AKT1S1 ITGA6 LAMA5 PRKAA2 COL2A1 LAMA1 LAMA4 LAMA3 SLC2A3 LIPE PRLR ANGPT4 THBS2 ANGPT2 COL1A1 LAMB3 COL3A1 ANGPT1 EGF LAMB2 LAMB1 RPS6KB2 CDKN1B SPP1 JAK3 OSMR HIF1A TNC OSM VEGFA COMP TNR CHRM2 BAD VTN CHAD PRKAA1 FOXO3A COL1A2 COL5A3 COL5A2 ITGB5 ITGB8 ATF6B PIK3R5 ITGB7 ITGB6 GNG10 VWF ITGA7 IGF1R THBS4 GNG12 PDPK1 THBS3 GNG11 RELN PPP2R5C GNG13 GNB2 GNB4 GNB3 GNG2 GNGT1 GNGT2 GNB1 EGFR FGF21 EIF4E1B GNG3 GNG5 CDC37 GNG4 NRAS GNG7 MAPK1 GNG8 HRAS SLC2A4 MAPK3 MAP2K1 GYS2 MAP2K2 SLC2A2 HEL-S-125m KPG_010 IBSP GRB2 GHR KRAS SOS1 RAF1 CREB3L3 CREB3L4 CAB39 IRS1 CREB3L2 PIK3CD RPTOR PFKFB2 MLST8 JAK1 RAB11B IFNAR2 CREB3 RPS6 CREB5 CREB1 CHRM1 PIK3R4 CSF3R IFNAR1 PIK3R2 PIK3R1 INS F2R EIF4EBP1 INSR EIF4E EIF4B MTOR RPS6KB1 HSP90AB1 FGF16 IL3RA IL2RG GSK3B PDGFA AKT3 CASP9 IL2RA IL2RB PPP2R1A HGF PPP2R5D LPAR1 LPAR2 LPAR3 LPAR4 MET IFNA7 IRS4 RAB10 IL6R IL2 IL7R FGF9 PRL FGFR2 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases RRM2B DPYS DPYD HEL74 ABAT UMPS TYMP DHODH RRM2 GLS2 TYMS OTC AGXT2 CAD NT5C3A RRM1 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260410%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy LITAF GDAP1 KIF1B MTMR2 SH3TC2 RABAC1 RAB25 EGR2 MPZ RAB7A PMP22 SBF2 FGD4 RAB4A RAB11A RAB11B NEFL HEL-S-102 MFN2 FIG4 LRSAM1 RAB3B RAB4B HSPB8 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260410%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex MCL1 PTEN ATM BCL2 EP300 ZFX GABPB1 TERF2 FOXO3A SMAD4 SMARCA4 GABPA BCL2L1 FLT3 DNMT3B ETV6 CREBBP PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260410%WP3527%HOMO SAPIENS Pre implantation embryo FOXQ1 MYBL1 SOX2 BATF3 FOSB DLX2 DDIT3 TFAP2B ZFP36 HMGA1 SMARCA4 TEAD4 POU5F1 ATP1A1 ELAVL1 E2F5 NANOGNB AQP9 DNMT3L NR3C2 KHSRP SIX3 FOXD1 SOX11 ZAR1 ARGFX DPPA3 ZFP42 PADI6 BARX2 ZFP36L2 LEUTX MTA3 CDX2 IRX5 TPRX1 HNRNPAB TBX3 MOS DPRX ZSCAN4 GATA3 MXD1 MACROH2A2 ESRRA KLF4 AQP3 IRF4 NKX2-1 PBX1 SOX8 TCF7L1 GATA2 EGR1 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260410%WP5145%HOMO SAPIENS COVID 19 structural coverage map UPF2 AQR ISG15 IGHMBP2 MACROH2A2 PARP14 GDAP2 ACE2 NLRP12 MACROD1 TOMM70 NRP1 HEL97 MACROD2 SLC6A19 CMTR1 PAIP1 PALS1 UBB UBC MAP3K7IP1 MACROH2A1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260410%WP500%HOMO SAPIENS Glycogen synthesis and degradation GYS1 HK3 HK2 PTPA GYS2 PYGL GYG1 CALM1 PPP2R1B PPP2R5C GSK3B PYGB PPP2R2A PYGM AGL PPP2R5E PPP2R3B PHKB PPP2R5B PHKA1 PPP2R1A PPP2R5A PHKA2 PHKG2 PPP2R3A PPP2R2C PPP2R5D PPP2R2B GSK3A PPP2CA SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260410%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR ACE2 NRP1 FURIN VEGFA COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260410%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity ATP11A PLSCR3 PLSCR4 TYRO3 SERPING1 MASP1 CD46 LLGL2 CRB2 PRKCZ PLSCR1 COLEC12 CRB1 ATP10A COLEC10 VTN C4A C1S CFH C1R CFI PARD6G CFP CD59 DEDD MARK1 PARD3 ATP8B3 MERTK PROS1 C4B_2 TGFB1 ATP8B1 C1QB C1QA ITGAM SCRIB ITGAV CASP9 CASP8 CASP10 ITGAX CX3CL1 CASP3 PARD6B C1QC CR2 APAF1 CX3CR1 MFGE8 TNFSF6 FAS CYCS CAP1 CFD BAK1 C2 MBP CD55 PARD6A BAX ITGB3 PALS1 ATP8B2 PRKCI AXL C5AR2 FCN1 FCN2 PATJ COLEC11 FCN3 IFNG DIABLO C6 C4BPA C7 C4BPB HTRA2 HEL-S-62p CLU C9 C8G C5AR1 C3AR1 DLGAP5 MBL2 MASP2 C8A CR1 ATP11C ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260410%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFB1 ACTA2 ACE2 AGTR1 RAF1 NOX4 MGRA RRAS SP1 MAPK1 PTPN11 IL6ST COL1A1 COL1A2 MAP2K6 SMAD4 HIF1A IL11 IL11RA TGFBR1 TGFBR2 JUND CTGF PDGFD CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260410%WP3594%HOMO SAPIENS Circadian rhythm genes PPP1CC PTEN EZH2 KCNMA1 MAGEL2 ID2 BHLHE41 CDK4 PRKAA1 BTRC NR1H3 NR1C1 TPH2 TPH1 NR1D2 PER2 DDX5 NGFR CRY2 RPS27A SIN3A AVP FBXW11 SLC9A3 AHR ROCK2 EP300 ADCY1 SIX3 HOMER1 NOS2 RORC SIRT1 IL6 DBP TYMS JUN CRY1 NFIL3 NR1D1 PER1 HEL-S-80p MAPK10 ATF4 NKX2-1 NAMPT CPT1A F7 TCF2 CREB1 CHRM1 DYRK1A UBC GFPT1 NCOR1 OGT C1orf51 PHLPP1 PROK2 AgRP PROK1 KCNH7 USP2 METTL3 SOX14 CARTPT CLDN4 SIK1 PSPC1 LEP TIMELESS TOP2A ATF5 CREM KMT2A HDAC2 MAGED1 PPARG HDAC1 OPN4 PRKDC OPN3 PPARGC1A NONO GSK3B NR2F6 NLGN1 SETX NPY2R ID4 PML HNRNPD NPAS2 FBXL3 MAPK8 KDM5A NPS SUV39H2 HEBP1 HEL-S-2 DRD1 RBM4 CRTC1 KLF10 CSNK1D KCND2 RAI1 BTBD9 SFTPC PAX4 HCRTR2 PROX1 HCRTR1 TNFRSF11A MC3R HS3ST2 PER3 SKP1 MTNR1B THRAP3 CIPC RELB GHRH CRH DDC RBM4B TH ATOH7 GHRL PROKR1 ADA NOCT CAVIN3 PASD1 UTS2R HDAC3 BMAL2 PRKAA2 UTS2 BHLHB2 AANAT FAS MTNR1A ID3 NTRK3 KLF9 NTRK1 CCAR2 CSNK1E STAR MTTP ARNT2 HTR7 ADORA2A RORA ZFHX3 SFPQ CHRNB2 RORB UBE3A DRD2 DRD3 DRD4 SUV39H1 MAPK9 PRF1 EGR1 CRX JUND MYBBP1A GNA11 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP5094%HOMO SAPIENS Orexin receptor pathway VHL PIK3R2 PIK3R1 PRKCZ LHB EIF4EBP1 OPRK1 EIF4B PRKAA1 STAT3 PTPN11 MTOR RPS6KB1 SMAD1 GNRH1 BMP7 LEP RPS6KA1 DKFZp781O1323 PDPK1 TNF CASP9 GNAI1 ARRB2 MAPK8 CGA CASP3 SLC1A2 HCRTR2 HCRTR1 GNAS IL10 CXCL2 TH GHRL PRKD1 NPFFR1 DAGLA NPY NPVF DYNLT3 HCRT GCG CXCL8 CCK NOX4 MAPK7 FOXO1 IL9 POMC DYNLT1 CAMKK2 MAPK1 SLC2A4 MAPK3 IL6 STAR RUNX2 MAP2K1 MAP2K2 SGK1 NFE2L2 MAPK14 BGLAP IL4 PRKCB PRKCE PRKCA GH1 IL1B HIF1A RPS6 MAPK9 FSHB CREB1 GNA11 BMPR1A 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36A IL36B SOCS3 IL36RN SOCS1 IL36G ARF6 IL1F10 CXCL13 PLCG2 STAT1 BCL2L11 MERTK IL1RN IL37 ANAPC1 IL1R1 IL23A POLR2F POLR2H IL1A POLR2K POLR2L CHTM1 ZC3H8 ZNRD1 PSD4 ARL14 CKAP2L POLR1A POLR1C POLR1D POLR1F POLR1G MAPK1 FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 IL6 TTL IL1RL2 NT5DC4 GATA3 CSF2 GRB2 CSF1 IL2 RAC1 IL1B PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260410%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway EZR SEPTIN2 MYL2 OCRL RDX RAB35 KIF23 HEL70 ARHA POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260410%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL1A TLR4 CCL11 HMGB1 TMPRSS2 CXCL8 ACE2 IL2 TLR3 IFNA2 TNF IL4 IL18 MAPK1 IL1B IL6 IL12A IFNG IL10 TLR8 FURIN TLR7 GFAP COPPER HOMEOSTASIS%WIKIPATHWAYS_20260410%WP3286%HOMO SAPIENS Copper homeostasis COX11 ADAM10 PTEN STEAP3 FOXO1 SLC11A2 CCS HEL-S-44 SP1 FOXO3A APP JUN SLC31A1 MDM2 STEAP4 COX17 ATP7B ATP7A COMMD1 PIK3CA SLC31A2 ATOX1 SCO1 ADAM9 XAF1 MT2A STEAP1 STEAP2 GSK3B CCND1 PRNP CASP3 MT4 ADAM17 MT3 MT1A MTF1 MT1F MT1G BACE1 MT1B APC MT1E INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260410%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IL1A IRAK1 AJUBA SQSTM1 HEL-S-71 PRKCZ TIFA NFKB1 TRAF6 UBE2V1 PURINE METABOLISM%WIKIPATHWAYS_20260410%WP4792%HOMO SAPIENS Purine metabolism HPRT1 ADSL DGUOK IMPDH1 AMPD1 HEL-S-70p XDH ADSS APRT ADA PNP POLYOL PATHWAY%WIKIPATHWAYS_20260410%WP690%HOMO SAPIENS Polyol pathway KHK SORD AKR1B1 ALDOB INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP453%HOMO SAPIENS Inflammatory response pathway LAMA5 IL5RA VTN TNFRSF1B IL5 CD40LG COL1A1 COL1A2 COL3A1 LAMB2 THBS1 LAMB1 TNFRSF1A LAMC2 LAMC1 CD40 CD80 IL2RG THBS3 IL2 IL4 IL2RA IL2RB IFNG ZAP70 LCK BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260410%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment MYC HEL2 BAD FOXO3A TIAM1 PLCG1 PARD3 DOCK7 PIK3CA NGFR PDPK1 TP73 RTN4R WASL YWHAZ PARD6B EEF2K ROCK2 YWHAQ IKBKB IKBKG MAP3K5 NRAS MAPK1 KIDINS220 HRAS MAPK3 MAP2K4 PARD6A JUN HEL-S-47e MAP2K1 MAP3K1 MAP2K2 GRB2 KRAS SOS1 RAF1 IRS1 PIK3CD PRKCI RAC1 LEF1 HEL-S-15 CREB1 RAPGEF1 MAP2K5 CRK BDNF ROCK1 PRKCZ EIF4EBP1 CDC42 EIF4E ARHA STAT3 CFL2 BCL2L11 PTPN11 MTOR RPS6KB1 BMP7 GSK3B TRADD HEL-S-1 CASP9 MAPK8 PAK1 CASP8 CHUK FRS2 FADD IQGAP3 NFKBIA EEF2 APAF1 TRAF6 MAPKAPK2 BCL2 LINGO1 CYCS MAPK7 LIMK1 YWHAG SORT1 NTRK2 BAX RPS6KB2 SH2B2 NPTX2 SMPD1 PRKCH MAPK11 PRKCB PRKCE PRKCA CTNNB1 TCF7L2 TCF7L1 ARHGAP35 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260410%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TGFB1 CLDN4 ERBB4 MYC TNF CCND1 NRG3 ALPL ZEB2 ITGB1 ITGA6 SFRP1 TERT RETT SYNDROME%WIKIPATHWAYS_20260410%WP4312%HOMO SAPIENS Rett syndrome CRK SCN8A SCN2A FOXG1 HDAC5 NCOR2 SYNGAP1 NCOR1 SHANK3 BRAF SYNE2 HDAC1 SMC1A GABRA3 KDM5B TRRAP ACTL6B HTT GPS2 CHD4 HDAC8 MEF2C RHOBTB2 GNAO1 CECR2 CDKL5 SMARCA4 TAF1B TBL1X STXBP1 HIVEP2 EIF2B2 KCNJ10 SCN1A SMARCA1 XAB2 GRIN2B TBL1XR1 GABBR2 IMPDH2 SRRM3 TCF4 HAP1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260410%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 CD40 PHF19 MHC2TA BLK STAT4 ITGAV IL2RA IL6ST CTLA4 CCR6 HLA-DRB1 SLC22A4 TRAF1 MALE INFERTILITY%WIKIPATHWAYS_20260410%WP4673%HOMO SAPIENS Male infertility CCNK H4C9 PRDM9 SIRPG EPSTI1 SLC16A7 RAG1 NANOS1 FAT10 PRM2 PRM3 FOLH1 SPATA17 MSH4 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 STRA8 DND1 MOV10L1 H2BW1 TMEM132E XRCC3 PRMT6 TAS2R38 PUM2 DAZL PIWIL2 PIWIL1 PIWIL4 SPO11 HORMAD2 MSMB PACRG TEX15 CXXC1 ABLIM1 OR2W3 XPC PMS2 MAS1L P1 KDM3A USP26 CDC42BPA MLH3 HMGA1 REC8 CTCFL GNAO1 ERCC1 ERCC2 SEMG1 BRDT SRD5A2 NQO1 AHR PEX10 EP300 CDK9 CYP1A1 AHRR NOS2 THBS1 AGO2 MDM2 NFE2L2 CREBBP MTR SOX5 GPX1 POLG H3-4 RFC1 ETV5 CLU MMP2 MMP9 PON2 PON1 INSR UBE2B CYP17A1 HEL-S-61p HEL110 ABCB1 MTRR PEMT TNF TCN2 XRCC5 SHMT1 SIRPA PARP1 TNFSF6 BCL2 FAS APOB BRCA2 CYP26B1 HLA-DRA PSAT1 NR3A2 ATM TRIP13 SLC46A1 MTHFD1 CHD2 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260410%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17A IL17RC IL17RA ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260410%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PSEN2 CSNK1A1L APH1B VDAC3 PSENEN ATP2A1 DDIT3 ULK2 ULK1 PPIF PLCB4 PIK3CA SLC25A5 CACNA1F PLCB1 PLCB2 CACNA1S RTN4 KIF5A HEL-S-61 ATP2A2 TUBA1A PTGS2 IKBKB MAP3K5 NOS2 ERN1 APP IL6 RYR3 PPP3CA LRP5 LRP6 ATF4 CSF1 PSEN1 IL1B GPR83 BACE1 NAE1 MCU RB1CC1 WIPI1 CYBB TRAF2 ATG2A CHUK ADAM17 GRIN2B EIF2S1 APOE NOX4 CDK5R1 GRIN1 SHFM1 RELA MAPK9 BAD PPP3CC CHRNA7 PIK3R3 ITPR2 SLC25A4 PPP3R2 NRBF2 ATG2B IDE TUBA1C MME TUBB LPL TUBB2A KNS2 PSMA8 TUBA3E TUBB4B TUBB4A TUBB8 TUBB6 TUBB1 AMBRA1 ATG14 TUBA4A HSD17B10 RTN3 CACNA1C ARAF KLC4 NRAS KLC3 KLC2 TUBA2 TUBA8 MAPK1 SLC25A6 HRAS TUBAL3 BECN2 MAPK3 ADRM1 SLC25A31 MAP2K1 MAP2K2 BRAF MAPK10 CALM1 PLCB3 CDK5 KRAS RAF1 IRS1 PIK3CD HEL-S-162eP PSMD12 HEL-S-276 HEL-S-91n PIK3R4 PSMD13 PIK3R2 PIK3R1 PSMB6 AGER PSMD9 PSMD6 INS PSMD7 EIF2AK2 PSMB2 PSMD4 INSR PSMB3 PSMD2 PSMD3 PSMD1 MTOR PPP3R1 PSMC6 PSMA4 PSMC4 PSMA2 PSMC1 GSK3B TNF AKT3 CASP9 MAPK8 CALML6 CASP8 CALML3 CALML4 CASP3 FADD WNT3A AXIN1 DKK4 APAF1 APC IL1A WNT2B FZD10 FAS FRAT1 CYCS FRAT2 IRS4 TUBA1B APC2 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 XBP1 CSNK1E AXIN2 WNT16 DKK1 DKK2 SFRP4 NFKB1 CSNK2B TNFRSF1A SNCA ATG101 DVL1 WIPI2 DVL2 CASP12 DVL3 WNT1 WNT3 FZD1 CTNNB1 WNT10B WNT10A FZD3 FZD2 FZD5 CSNK1A1 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260410%WP259%HOMO SAPIENS Nifedipine activity KDR MAPK1 PTK2B MAP2K1 PCNA BDKRB2 HEL-S-44 CYP3A4 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome H4C9 PLK1 GLUD1 MED15 SREBF2 VWF CLDN5 SNAP29 RTN4 RELN SHH RTN4R CLDN1 POLR2A SLC25A1 EGFR DGCR8 DROSHA PAK4 RORC RAN SLC2A4 TSKS EMC10 ZDHHC8 RCC1 PITX2 C22orf39 CLDN3 THAP7 SHOC2 TSSK2 HEL-S-80p ASF1A RTL10 NPRL2 TRMT2A ACTA2 ESS2 FGF8 HEL25 RAF1 KLHL22 GP5 UFD1L LRRC74B SEPT8 MRPL40 DGCR6L TNPO1 CRKL SCARF2 DGCR2 GP1BB C16orf35 GP1BA SEPT5 SLC7A4 CYP26C1 ALDH1A2 GNB1L DEPDC5 CCDC188 FOXC1 ARVCF TBX1 RANBP1 SERPIND1 P2RX6 ZNF74 PAX3 GP9 CDC42 RBX1 NKX2-5 NCOR1 HAND2 CLTCL1 FGF10 FGFR1 FOXA2 PRODH TXNRD2 GBX2 CDH15 HDAC3 PARK2 HIRA BCL2 HIRIP3 CYP26A1 CYP26B1 CDC45 DRD2 FOXC2 GSC2 FGFR2 HES1 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260410%WP2857%HOMO SAPIENS Mesodermal commitment pathway SMAD2 RPL38 SOX2 PRKAR1A TOX SETD2 TEAD2 TET1 VAV3 PPP2CA BMP4 TCF4 SNAI1 YAP1 BMPR2 LEFTY1 LEFTY2 FOXA1 SOX21 CEP250 HMGA2 PITX2 WDHD1 NFE2L2 DNMT3B TBX3 FOXH1 EMSY WDFY2 HPRT1 FGF8 GATA6 MBTD1 EPB41L5 UBR5 FZD4 ATP8B2 GDF3 ZFHX4 TRERF1 NABP2 LEF1 PLCH1 RARB NODAL FOXC1 PIAS1 TRIM71 TBX1 PHF6 HES7 NR2A1 ZIC3 CCDC6 ACVR1 TRIM5 ADAM19 SMAD6 C1QBP TBX6 TWSG1 JARID2 INHBA SCHIP1 CSRP2 SLC2A12 MSGN1 PAX6 PARP8 ARL4A NR1B3 HAND1 TOX3 WDCP AEBP2 ACVR2B ARID5B ACVR2A MEIS1 AHDC1 BCORL1 ZNF462 SMAD1 ELP4 FGFR1 ZIC5 ACACA RGS10 SESN1 MIXL1 BMP7 FOXA2 CUL4B CCND1 CRTC1 LATS1 SMAD4 WNT3A EXT1 AXIN1 EXT2 POU5F1 C9orf72 BHLHB2 SOX17 PBX3 TRIM28 ZIC2 AXIN2 DKK1 GATA3 CTBP2 NLK KLF4 NOG KLF5 PBX1 FOXC2 WNT3 HTT TCF7L1 AMH FZD5 FZD8 BMPR1A CILIOPATHIES%WIKIPATHWAYS_20260410%WP4803%HOMO SAPIENS Ciliopathies TMEM67 RAB23 PDE6D NPHP3 EVC2 BBS2 NEK8 BBS1 USP9X PCARE SCLT1 DCDC2 BBIP1 INPP5E TTC8 MKS1 IFT27 CEP41 TRIM32 CLUAP1 OCRL INTU HEL-S-296 SMO SUFU KIF7 GLI3 ADCY6 CCDC40 ANKS3 XPNPEP3 PIBF1 NPHP1 PIK3R4 ODAD1 ODAD3 ODAD4 CCDC28B MCIDAS TBC1D32 NEK2 DNAAF3 DNAAF2 DNAJB13 DNAAF6 FAM161A TMEM138 CCNQ CCNO AK7 CEP78 NEK9 DNAAF19 ARL2BP TMEM237 UNC119 DNAL1 ZNF423 DNAAF11 AHI-1 HYDIN CCDC39 DNAI2 CFAP52 PLK4 TOPORS RP1 NME7 NME9 WDR51B ZMYND10 KIZ CFAP53 KATNIP DRC1 DNAH6 RSPH9 CFAP298 POC1A RAB28 DNAI1 TUB DYX1C1 C2CD3 RSPH3 CEP19 RPGRIP1 RP1L1 CENPF TTLL5 TCTN3 RSPH1 TCTN2 ALMS1 TCTN1 SPAG1 HYLS1 B9D2 ATXN10 CC2D2A OFD1 DYNC2I2 INVS TRAF3IP1 IFT172 RPGRIP1L CEP164 CCDC41 PKD1 IFT52 FLCN ZIC2 TMEM107 TULP1 CNGA1 NEK1 BBS9 BBS7 IFT57 KIAA0753 BBS5 CEP290 CPLANE1 BBS4 DYNC2H1 IQCB1 CFAP418 TMEM231 IFT140 IFT80 TMEM17 CFAP410 WDR35 LZTFL1 B9D1 EVC BBS10 IFT43 BBS12 RP2 IFT81 GPR161 MAK TMEM216 EFHC1 WDPCP CNGB1 SDCCAG8 CEP104 ARL6 ARL3 DYNLT2B CRX PKD1L1 DYNC2LI1 PKHD1 ARL13B MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260410%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GOT2 SLC25A22 SLC25A13 SLC25A12 GLUD1 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260410%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways CBS GAD1 CTH HEL-S-44 GAD2 pcap HEL-S-61p MTHFD2 HEL-S-182mP CDO1 PCYT1B CHKB PCYT2 CHKA ETNK1 PEMT AHCYL2 MAT1A BAAT CHPT1 PSPH GCLM SHMT1 AGXT2 DHFR AHCYL1 DNMT3L PHGDH SLC25A48 GPX7 GCLC BCAT1 HEL-S-51e BCAT2 BHMT2 HEL-S-75p MTHFD1L TYMS AMT PSAT1 CHDH DNMT3B ALDH7A1 MTR GPX2 GPX1 GPX4 HEL-S-64p GPX3 GPX6 HEL-75 CEPT1 MTHFD1 MTHFD2L MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response BBC3 CDK6 CHEK2 MYC TLK1 CDC2 CDK4 TNFRSF10B TP53AIP1 SESN1 CCND3 RB1 PRKDC CCNB2 CCND1 PML CASP9 RAD51 CASP8 CASP3 CDKN1A APAF1 RRM2B GADD45B GADD45A GADD45G FAS CCNG1 CYCS CCND2 SFN CHEK1 H2AX RAD1 ATRIP HUS1B ATR TLK2 RAD9A CCNB3 CCNE1 BAX FANCD2 CDK2 MDM2 RAD50 CCNE2 CDK5 MRE11A ATM BRCA1 NBN PMAIP1 SMC1A CDKN1B RAD52 RAD17 PIDD1 RFC1 CCNB1 DDB2 CREB1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260410%WP4172%HOMO SAPIENS PI3K Akt signaling CDK6 PTEN LAMB4 EPOR KDR FLT3LG EPHA2 PDGFD PIK3CA PDGFC NGFR TCL1B PPP2R1B IGF2 IGF1 PHLPP2 CSHL1 GHB3 PPP2R5E FGF8A PPP2R5B PPP2R5A PPP2R3C CDKN1A PPP2R3A PPP2R2C PPP2R2B PPP2R2D PPP2CA FGF7B FGF7A GYS1 KIT FGF18 FGFR3 ATF2 FGF6B NTF4 NTF3 IKBKB IKBKG TSC1 VEGFB FGF5C IL6 VEGFC RHEB VEGFD CCNE1 THBS1 CDK2 MDM2 FGF2 CSF3 ATF4 FGF7 CSF1 FGF8 EPO ITGB3 ITGA2B PDGFRA TSC2 PCK1 COL4A2 MYB COL4A1 PPP2R2A COL4A4 COL4A3 COL4A6 COL4A5 PPP2R3B CSF1R EFNA5 EFNA4 FGF20 FGF23 FGF22 MCL1 BDNF XB EFNA1 EFNA3 FGF14 IL3 KITLG EFNA2 FGFR4 FGF13 FGF12 PHLPP1 FGF10 FGFR1 ITGB1 FLT1 ITGB4 FLT3 STK11 FLT4 LAMC2 DDIT4 LAMC1 TCL1A ITGAV ITGA4 ITGA2 SYK ITGA1 NGF CHUK IFNB1 ITGA6 CD19 TLR4 LAMA5 PRKAA2 COL2A1 LAMA1 PIK3AP1 LAMA4 LAMA3 PRLR NTRK1 NTRK2 ANGPT4 THBS2 ANGPT2 COL1A1 LAMB3 ANGPT1 EGF LAMB2 LAMB1 RPS6KB2 BRCA1 CDKN1B SPP1 JAK3 PRKCA OSMR PKN2 RELA TNC OSM VEGFA PCK2 COMP G6PC2 TNR G6PC3 MYC CHRM2 BAD VTN CHAD CDK4 PRKAA1 FOXO3A COL1A2 ITGB5 PIK3R3 ITGB8 ATF6B PIK3R5 ITGB7 ITGB6 GNG10 VWF G6PC1 ITGA7 IGF1R CCND3 THBS4 GNG12 PDPK1 THBS3 GNG11 RELN PPP2R5C GNG13 RBL2 GNB2 GNB4 GNB3 GNB5 GNG2 GNGT1 GNGT2 GNB1 EGFR FGF21 EIF4E1B GNG3 GNG5 CDC37 GNG4 NRAS GNG7 MAPK1 GNG8 HRAS MAPK3 MAP2K1 GYS2 MAP2K2 HEL-S-125m KPG_010 IBSP GRB2 GHR KRAS SOS1 RAF1 SOS2 CREB3L3 CREB3L4 IRS1 CREB3L2 IF1AA9 PIK3CD RPTOR GH1 MLST8 RAC1 JAK1 IFNAR2 CREB3 RPS6 CREB5 CREB1 CHRM1 CSF3R IFNAR1 PIK3R2 PIK3R1 IFNA13 IFNA14 IFNA16 IFNA17 INS F2R EIF4EBP1 INSR IFNA10 EIF4E EIF4B BCL2L11 MTOR IFNA21 RPS6KB1 HSP90AB1 IFNA1 IL3RA IL2RG GSK3B PDGFA CCND1 AKT3 CASP9 IL2RA IL2RB PPP2R1A HGF TGFA PPP2R5D LPAR1 LPAR2 LPAR3 LPAR4 TNFSF6 MET BCL2 IFNA4 IFNA7 IFNA6 IFNA2 CCND2 IFNA8 COL9A1 COL9A3 COL9A2 PKN3 GHB2 PKN1 CSH2 BCL2L1 COL6A1 SGK1 COL6A6 SGK2 NFKB1 COL6A5 IL6R CCNE2 IL2 IL4 IL7 IL7R FGF9 PRL FGFR2 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260410%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IRF9 IFNAR1 MX1 SOCS1 OAS1 STAT1 STAT2 IFNGR1 IFIT1 IFNGR2 IRF1 JAK1 IFNAR2 IFNG TYK2 IFITM1 PSMB8 PIAS1 TAP1 IFI35 IFIT3 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome CLASP2 BRD4 ATP5PB TMEM270 MYC ATP5F1D USF1 ATP5F1E TBL2 ATP5PO GTF2IRD1 PCNA UBIAD1 ULK1 ACACB ACACA PRKG1 CLDN5 CLDN4 OGDH HDAC2 DLD RB1 SNAP25 HOXC8 CDKN1C HMGA1 GRIP1 GTF2I CLTC CLDN1 LAT2 VAMP2 BTK ATPAF2 HDAC3 SQSTM1 HSPA2 FAS LIMK1 H2AX MAPK3 CLDN3 EIF2A UBE2L6 CHTF18 ATP5G1 ATF4 HEL-S-271 GRB2 BCL7B BUD23 VPS9D1 UBE2E3 VPS37C UBE2E1 BAZ1B VPS37D NRG1 VPS37A VPS37B MLXIPL CLIP2 DDX21 METTL27 FKBP6 CTNNB1 VPS28 STX1A ATPAF1 SF3B1 TRIM50 NUP62 TSG101 ATP8 PKLR RFC2 ATP6 SMARCA5 ATP5MC2 DEK ATP5MC3 FBLN2 HEL-S-123m HEL-S-15 MYO1C ABHD11 HEL-S-162eP FBLN5 CLASP1 FZD9 MYBBP1A HDAC6 MVB12A FBN1 EIF4H FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2879%HOMO SAPIENS Farnesoid X receptor pathway ABCB4 PPARGC1A BAAT IP6K3 ABCB11 FKBP5 CYP8B1 SLC27A5 FGF8A UGT2B4 RXRA NR1H4 SULT2A1 CYP7A1 NR0B2 SLCO2B1 CYP3A4 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma STAT3 IL6ST JAK1 IL6 RELA IL11 IL11RA JAK3 SOX4 NFKB1 IL6R NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260410%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium ERBB4 BDNF MYC TCF3 DAB1 NTRK3 ID1 PAX6 CDK5R1 PLXND1 SOX2 CXCL12 LRP8 ID2 NDEL1 MAP1B NTRK1 NEUROG3 MAP2 NTRK2 AGRN FAIM STAT3 PAFAH1B1 DISC1 APP NEUROD1 IL17A CDK5 NGFR MRE11A NUMB RTN4 RELN GSK3B NRG1 KDM1A RTN4R VLDLR PSEN1 NGF MEF2C NOTCH1 ASCL1 GHRL RET HES1 TCF4 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260410%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PLA2G2A HMFN0839 PTPMT1 PGS1 PIP5K1A GPAT4 GPAT2 CDS2 IPMK MOGAT3 CDIPT PIK3CA PTDSS1 CHKB PCYT2 PI4K2A PEMT CHPT1 PIK3CD GPAM GNPAT GPD1 AGPS CEPT1 LPIN1 LPIN2 PEPTIDE GPCRS%WIKIPATHWAYS_20260410%WP24%HOMO SAPIENS Peptide GPCRs OPRK1 ATP8A1 BRS3 MC4R CCKAR GHSR LHCGR NPY5R IL8RB AVPR1B NPY1R TACR2 OPRM1 AVPR1A SSTR3 CCR10 SSTR4 FPRL2 CCR1 TRHR SSTR5 CCR5 OPRD1 NPY4R FPR1 MC2R OXTR GALR3 NPY2R GALR2 GALR1 TAC4 NTSR2 NMBR CXCR1 MC1R TACR1 MC5R SSTR2 EDNRA FSHR TSHR EDNRB HCRTR2 CCR8 HCRTR1 CCR7 MC3R CCR6 CCR4 CCR3 CCR2 CX3CR1 AGTR2 CXCR5 CCKBR CXCR6 CXCR3 GRPR GNRHR AGTR1 FPR2 BDKRB2 BDKRB1 AVPR2 CXCR4 FY C5AR1 NTSR1 C3AR1 TACR3 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260410%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc OGDH SUCLG2 DLD HEL-S-32 PCK1 HEL-S-26 HEL60 DLAT FH PDHA1 SDHA ACLY CS PC RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260410%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation LTB4R MTOR CMKLR1 GRK1 PIK3CD FPR2 PIK3CA EPHB2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260410%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CYP2E1 ADH5 CBS MTR CEBPB CREB1 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260410%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD HMGB1 CHUK RELA AGER NFKBIA IKBKB IKBKG NFKB1 THBD CCL18 SIGNALING%WIKIPATHWAYS_20260410%WP5097%HOMO SAPIENS CCL18 signaling MMP2 ZEB2 AK4 CCR8 CDH2 PTK2B SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260410%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 IL5 SIGNALING%WIKIPATHWAYS_20260410%WP127%HOMO SAPIENS IL5 signaling IL5RA PIK3R2 PIK3R1 STAT1 MAPK1 STAT3 FOXO3A PTPN11 MAPK3 RPS6KB1 JUN MAP2K1 RPS6KB2 MAP2K2 CSF2RB LYN GRB2 RPS6KA1 KRAS SOS1 RAF1 GSK3B IL2 SYK JAK1 SPRED1 RPS6 BTK STAT5B GSK3A CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260410%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism POR CYP11A1 HSD3B2 HSD3B1 HSD17B3 STAR H6PD HSD11B1 HSD11B2 SRD5A2 CYP17A1 CYP11B2 CYP21A2 NAD METABOLISM%WIKIPATHWAYS_20260410%WP3644%HOMO SAPIENS NAD metabolism SIRT4 SIRT5 SIRT7 NT5E SIRT2 SIRT3 NMNAT1 NAMPT SIRT1 SIRT6 NRK NMNAT3 NMNAT2 NADK PARP1 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260410%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells TGFB1 TLR4 CD40 SELE CCL5 CCL2 CD40LG VCAM1 IL1B SELP SELPLG TLR7 PF4 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260410%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease KCNN3 RBPJ C4orf54 BEND6 NOX3 EFL1 SHCBP1 ARHGAP31 IBTK EIF6 SBDS CDC42 SP1 MAPK1 MAPK3 NFKB1 DGUOK NCF2 NCF4 CYBB CYBA RAC1 NOTCH1 GTF2I BTK TLR9 DOCK6 TLR8 CYBC1 NCF1 COX4I2 DLL4 CXXC5 CHCHD2 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260410%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 IFNAR1 PTEN PIK3R1 PPP3CC STAT4 FYN FOXO3A CTLA4 MTOR PLCG1 PTPRC IL18R1 NFATC1 PDPK1 GSK3B TNF CCND1 CHUK PRKCQ IL12B IFNB1 LAT CDKN1A IL12A IL23A NFKBIA CARD11 BCL10 MYD88 IRF2BPL IKBKB LTA IKBKG IL23R TSC1 MAPK1 FOS CD3G HRAS CCL19 CDKN2A CD3E MAPK3 CD3D RHEB BAX JUN HLA-DRA MAP2K1 HLA-DRB1 BCL2L1 MAP2K2 CCL28 NFKB1 IL17A GRB2 CD80 SOS1 DEPTOR RAF1 IL2 IL4 TSC2 PIK3CD GRAP2 RPTOR MLST8 LCP2 ICOS IFNAR2 RELA IFNG TYK2 RICTOR ZAP70 IL12RB1 LCK FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260410%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 LPL APOA2 APOA4 APOA5 APOC2 LDLR LIPC SEL1L GPIHBP1 PLTP LMF1 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260410%WP2006%HOMO SAPIENS miR targeted genes in squamous cell RARS1 ADAR NCL PTMAP7 SRSF9 RAI14 SDCBP PNP GAS2L1 MAP3K8 SLC4A10 GOLGA7 ATP6V0E1 P4HA2 TNFRSF10B CHMP2A SRPRB DKFZp761E1322 PISD PICALM RAB34 SYNE2 POM121 TMED10 ADIPOR2 RTN4 SIGMAR1 MRPL20 SEC23A ATP6V1F HSD17B12 HMGA1 TBCA SH3BP4 PDLIM7 ARF4 SLC12A2 FBXW11 GALNT7 ATP2A2 MRC2 BET1 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 GALNT1 NRP1 SH3BGRL3 HMOX1 HOXA7 ANXA2 PRPF40A CTDSP1 HEL-S-26 RHEB THBS1 DNAJB1 FGF2 POLR2C TPM3 TPM1 AP3D1 ARCN1 FMNL2 POLD2 VCAM1 AP2A1 PXDN NF2 GFPT1 NEDD4 SMAD1 CUL4B CPNE8 LAMC1 VEZT PWP1 DHX57 E2F3 CIAO2A HEL-S-30 SLC38A1 CBFB TRAM1 FNDC3B FNDC3A UBE2J1 TGFBR2 COMMD9 ATP6V1C1 MET PEDS1-UBE2V1 MOV10 ANP32B RNP24 MAGT1 TMED7 CSDE1 MRPS33 AKAP8 PPP1R7 MPZL1 ELOVL5 TMEM59 SPCS3 AXL LAMTOR5 POGLUT3 HES1 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD ERBB SIGNALING%WIKIPATHWAYS_20260410%WP673%HOMO SAPIENS ErbB signaling CRK CAMK2G MYC PIK3R2 NCK2 PIK3R1 NCK1 CBL BAD EIF4EBP1 PLCG2 BCL2L11 MTOR RPS6KB1 SHC4 BTC SHC2 SHC3 PIK3R3 PIK3CA PDPK1 GSK3B CCND1 AKT3 MAPK8 PAK1 AREG CDKN1A TGFA ERBB2 ERBB4 EGFR HBEGF ERBB3 FOXO1 PAK6 ARAF NRAS NRG2 EREG MAPK1 PAK4 NRG4 HRAS ABL2 MAPK3 EGF MAP2K4 JUN MAP2K1 RPS6KB2 MDM2 MAP2K2 BRAF MAPK10 GRB2 KRAS SOS1 RAF1 SOS2 CDKN1B NRG1 PIK3CD NRG3 CRKL PRKCB PRKCA SRC MAPK9 CAMK2D CAMK2A STAT5B 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5402%HOMO SAPIENS 10q22q23 copy number variation ADAM10 GLUD1 CEBPA DNAJB13 MAD2L2 PPARG OPN4 MAT1A RSPH9 RSPH3 BMP2 ERBB4 RSPH1 MGRA SH2D4B FAM25A BUB1B ADIRF LDB3 GHITM IQUB WAPAL ROPN1L RSPH6A ACTN2 NFKB1 NME5 CDHR1 MMRN2 SIRT4 DYDC2 DYDC1 RAD21 ZMYND11 RGR TNFSF11 PDS5B PDS5A SMC3 GPR15LG SMC1A SNCG SH3GL3 GPR15 SUSD2 STAG1 TSPAN14 NRG3 LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 VEGFA BMPR1A PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260410%WP4971%HOMO SAPIENS Phosphoinositides metabolism MTMR1 MTMR2 PIK3R4 PTEN MTMR8 PIK3C2G PIK3C2A SBF2 STM7 MTMR6 PIK3C2B MTM1 PIP4P2 PIP4P1 INPP5D PLCH2 PLCG2 PIP4K2A PIP5K1A PLCE1 PIP4K2B PLCG1 PIP5K1C SACM1L OCRL PIKFYVE PLCB4 PIK3CA PLCB3 PLCD3 PLCB1 PLCB2 PLCD4 PIK3CD MTMR10 MTMR3 MTMR12 MTMR11 PLCH1 MTMR9 MTMR4 SBF1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260410%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 FOXO1 EIF4EBP1 TSC2 PRKCA MAPK1 CGA APPL1 H3-4 SRC MTOR FSHR RPS6KB1 MAPK3 RPS6 RHEB RPS6KB2 FSHB SGK1 CREB1 MAPK14 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling EGLN2 MMP2 IL1A MMP9 SELE CXCL8 PTGS2 IKBKB CD40LG NFKB2 IL6 REL NFKB1 TNFRSF1A BIRC5 CSF2 BIRC2 BIRC3 BCL2A1 IL2 TNF BCL2L2 CCND1 MMP3 VCAM1 CHUK IL1B RELA RELB CXCL2 VEGFA TRAF6 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome SLC35G5 PRSS55 CSTA PRSS51 MTMR8 MCRS1 DEFB136 CGAS C8orf74 DEFB135 BLK MTMR6 DEFB134 TBX5 MFHAS1 FAM167A FCGR2B XKR6 SLBP TERT S100A10 HEL-S-130P AXIN1 HSPD1 TLR4 RP1L1 SGPL1 MAPK1 BMP1 PDX1 MSRA NKX6-1 SLC2A4 MAPK3 SOX7 TNKS RAF1 GATA4 TERF1 CTNNB1 PPP1R3B FCGR2A MTMR9 NEIL2 ERI1 NUMA1 FDFT1 PINX1 HEPACAM2 CLDN23 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2874%HOMO SAPIENS Liver X receptor pathway NR1H3 RXRA SCD CYP7A1 CYP2B6 FASN ABCG8 ABCG5 CYP3A4 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260410%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDK6 HEL-S-34 PIK3R2 PIK3R1 SMAD2 BAD CDC42 dik STAT1 CDK4 STAT3 MTOR RPS6KB1 PIK3R3 PIK3CA TGFB1 RB1 E2F2 E2F3 CCND1 CASP9 AKT3 RAD51 MAPK8 PAK1 CHUK SMAD4 CDKN1A TGFA TGFBR1 TGFBR2 ERBB2 EGFR GADD45B GADD45A GADD45G BRCA2 IKBKB RAC3 PAK6 ARAF IKBKG BAK1 MAPK1 PAK4 CDKN2A MAPK3 EGF BAX MAP2K1 RPS6KB2 BCL2L1 MAP2K2 BRAF NFKB1 RALBP1 MAPK10 KRAS PLD2 RAF1 PIK3CD POLK RAC1 JAK1 RELA DDB2 MAPK9 RALA RALB VEGFA THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260410%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production PRKAA2 SLC5A5 RAF1 RAP1A TRH PRKCA DUOX1 PRKAA1 CLCN5 MAPK1 CGA TG TSHR HEL-S-5 DUOX2 MAPK3 MAP2K1 MAP2K2 NFKB1 CREB1 TPO FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260410%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 LPL APOA2 ANGPTL4 APOA5 LDLR SEL1L GPIHBP1 LMF1 APOA4 APOC2 LIPC ANGPTL8 ANGPTL3 PLTP EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer RBPJ CLDN7 SMAD2 EZH2 SPARC VTN ID2 PIK3R3 CLDN5 PIK3CA CLDN1 MAPK13 SNAI1 TJP1 CTDSP1 MEF2D MAPK1 SUZ12 HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP2K1 GDF15 MAP2K2 CLDN3 MAPK14 LRP5 MAPK12 LRP6 GRB2 KRAS SOS1 RAF1 CDH2 JAG2 FMNL2 SOS2 JUP COL4A2 FZD4 PALS1 COL4A1 PIK3CD COL4A4 COL4A3 COL4A6 COL4A5 WNT9B WNT9A NOTCH1 WNT8A WNT8B NR2C2 CLDN23 MMP2 MMP9 FOXQ1 PIK3R2 PIK3R1 TWIST2 NOTCH2 NOTCH3 TUSC3 HEL-S-79 CLDN2 CDKL2 CLDN6 CLDN9 PKP2 PKP1 EIF5A2 NRP2 CLDN22 CLDN4 TGFB1 CLDN20 CLDN24 CLDN11 FOXM1 CLDN10 CLDN15 CLDN14 CLDN19 STRAP GSK3B CLDN18 CLDN17 CLDN16 TMPRSS4 AKT3 CRB3 EED MAPK8 PAK1 SMAD4 LATS2 WNT3A PROX1 TGFBR1 TGFBR2 TRAF6 WNT2B FZD10 ID1 RBBP4 WNT5B TWIST1 PKD1 SNAI2 WNT16 MMP15 NUBPL WNT1 FOXC2 MAPK11 WNT3 FZD1 CTNNB1 WNT10B ZEB2 WNT10A FZD3 HIF1A FZD2 FZD5 WNT4 WNT7B FZD7 FZD9 DLL3 DLL4 WNT7A FZD8 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260410%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-53e CYP2E1 ADH1C HEL-S-117 ADH7 CYP1A1 ADH6 ALDH2 CYP4A11 HEL-S-4 CYP2A6 ADH1A CYP3A4 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260410%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine SPR JDP1 PAH PTS PNMT AANAT DHFR ASMT DBH TH MAOA LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260410%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP PDPK1 SOCS3 IRS4 INS SOCS1 IRS1 INSR STAT3 DGKZ SOCS2 PIK3R3 LEPR MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260410%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IL1A TLR4 MYD88 CXCL8 IKBKB CCL4 IKBKG CCL3 IRF1 NFKB2 IL6 REL NFKB1 MAPK14 ELANE TNF MAPK8 LCN2 IRAK1 VCAM1 CHUK RELA MAP3K7 IRAK4 RELB IL10 NFKBIA MAP3K7IP1 TLR8 TRAF3 TLR7 TRAF6 IRF7 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260410%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG IL6 GLP1R INS SLC2A2 IL6R NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260410%WP4331%HOMO SAPIENS Neovascularization processes ACVRL1 MMP9 KIT SMAD2 CXCL12 KITLG NOTCH3 EPHB4 KDR MAPK1 MAPK3 ANGPT1 NFKB2 REL SMAD1 SMAD9 NFKB1 FLT4 TGFB1 DKFZp781O1323 MAPK8 EPHB2 HIF1A NOTCH1 RELA MAPK9 CXCR4 RELB TGFBR1 DLL4 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260410%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 MYD88 IFNB1 IFNG TNF TLR9 MAP1LC3A IRF3 NFKB1 TRAF6 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260410%WP710%HOMO SAPIENS DNA damage response only ATM dependent BBC3 PIK3R4 PTEN MYC PIK3R2 PIK3C2G PIK3R1 PIK3C2A PIK3C2B BAD CDC42 INSR ARHA FOXO3A BCL2L11 NFKB2 PIK3R3 PIK3R5 PIK3CA TGFB1 G6PC1 HMGB1 CCND3 PPP2R5C TP73 GSK3B RBL2 CCND1 AKT3 MAPK8 PPP2R5E SMAD4 BCL6 CDKN1A MLKL WNT3A MAP3K7 CCNG2 AXIN1 APC ERBB2 TNFSF6 WNT2B BCL2 FRAT1 CCND2 LDLR RAC3 BAK1 NRAS BIK WNT5B MAPK1 HRAS CDKN2A WNT16 BAX JUN MAP3K1 MDM2 NFKB1 MAPK10 GRB2 KRAS ATM SOS1 PMAIP1 SOS2 CDKN1B DVL1 DVL2 IRS1 DVL3 PIK3CD WNT1 WNT3 CTNNB1 WNT10B TCF7L2 RAC1 WNT10A TCF7L1 LEF1 MAPK9 WNT4 WNT7B WNT7A PCK2 FOSL1 HEART DEVELOPMENT%WIKIPATHWAYS_20260410%WP1591%HOMO SAPIENS Heart development NFATC3 BMP2 NFATC2 BHLHB2 ERBB3 TBX5 BMPR2 HAND1 MAPK1 NKX2-5 PTPN11 HAND2 VEGFB SMAD1 VEGFC FGF10 PITX2 FOXH1 FOXA2 NFATC1 GATA6 FGF8 GATA4 SHH FOXC2 HEY2 CTNNB1 MEF2C SMAD4 NOTCH1 BMP10 TBX20 FOXC1 SMYD1 IRX4 TBX1 ISL1 TBX2 VEGFA NFATC4 BMP4 BMPR1A SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260410%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF9 IFNAR1 IFNA4 IFNA13 ACE2 IFNA7 IFNA14 IFNA6 IFNA16 IFNA2 IFIH1 IFNA17 MAVS IFNA8 RIGI IFNA10 STAT1 STAT2 IFNA21 IFNA1 TLR3 IF1AA9 TBK1 IKBKE JAK1 IFNAR2 IFNB1 TYK2 TICAM1 IRF3 TRAF3 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260410%WP12%HOMO SAPIENS Osteoclast signaling CTSK IFNAR1 TRPV5 TNFSF11 TNFRSF11B ITGB3 ATP6V1G1 SPP1 AIMP2 MAPK8 IFNB1 TNFRSF11A GPR68 ACP5 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway SNW1 MITA IFIH1 MAVS CXCL12 RIGI IFNK TRIM25 IFNA1 TNF TRADD MAPK8 NFKBIB CASP8 TBK1 TRAF2 CASP10 IKBKE CHUK IFNB1 FADD MAP3K7 NFKBIA DHX58 IRF3 TRAF3 ATG5 TRAF6 MAPK13 IRF7 TANK DDX3Y OTUD5 DDX3X ISG15 AZI2 SIKE1 RNF125 CXCL8 IFNE CYLD PIN1 TBKBP1 IKBKB ATG12 IKBKG MAP3K1 NFKB1 MAPK14 MAPK12 MAPK10 RIPK1 NLRX1 MAPK11 RELA IFNG MAPK9 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 ABCA1 ELOVL4 MYLIP ELOVL3 PLPP6 ACSL1 HMGCS1 NR1H3 CYP46A1 HMGCR TM7SF2 HSD17B7 CYP7A1 SCD NR1H2 CH25H GGPS1 IDI2 ACAT2 ABCG1 FADS2 ELOVL5 ELOVL2 IDI1 CYP27A1 FDPS MVK CYP51A1 DHCR24 MSMO1 EBP PMVK SC5D MVD LBR FDFT1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260410%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance ABCB1 HIF1A CDKN1A BCL2L1 PURINERGIC SIGNALING%WIKIPATHWAYS_20260410%WP4900%HOMO SAPIENS Purinergic signaling LPAR4 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 PANX1 P2RY2 P2RY1 GNAT1 P2RY10 P2RY14 GNAZ P2RX7 P2RX5 P2RX4 ADORA2B P2RX3 ADORA2A P2RX2 P2RX1 GNAI3 GNAI1 GNAO1 GNAS P2RY13 GNA11 P2RY11 P2RX6 ESTROGEN SIGNALING%WIKIPATHWAYS_20260410%WP712%HOMO SAPIENS Estrogen signaling BCL2 IKBKB IKBKG SP1 MAPK1 FOS CHUK GNGT1 GNB1 MAPK9 GNAS JUN MAP2K1 BRAF NFKB1 CREB1 GPER MAPK14 PIK3CA PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260410%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m DNAJC3 DNAJB11 ATF3 BBC3 DNAJB9 ATF4 ERP27 PPP1R15A UBE2E1 HEL-S-89n TRIB3 XBP1 BCL2L11 HEL-S-99n ERN1 SULT1E1 DDIT3 NFE2L2 NARS1 EDEM1 ASNS EIF2A GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP4159%HOMO SAPIENS GABA receptor signaling ABAT AP2A1 GAD1 AP2S1 GAD2 GABRB3 GABRB2 GABRB1 SLC6A1 AP2A2 GABRE GABBR1 GABRQ SLC32A1 GABRA2 SLC6A11 GABRP ALDH9A1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG2 GABRG1 AP2M1 GPHN GABBR2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2406%HOMO SAPIENS Cardiac progenitor differentiation INHBA PAX6 INS TBX5 LIN28B SOX2 KDR NKX2-5 MIXL1 TGFB1 FOXA2 IGF2 GSK3B IGF1 SIRPA WNT3A TBX20 POU5F1 IRX4 ISL1 BMP4 KIT NCAM1 SOX17 ZFP42 BMP1 TNNI3 DKK1 FGF2 MAPK14 ROR2 NOG MYL2 MESP1 GATA4 SOX1 PDGFRA NRG1 THY1 MYH6 TBXT LIN28A MEF2C NOTCH1 SCN5A CXCR4 NODAL MYLK3 MESP2 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260410%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression PIK3R2 PIK3R1 RAF1 EIF4EBP1 TSC2 PIK3CD EIF4E HEL164 MAP3K5 PRKAA1 TSC1 MAPK1 MTOR MAP2K6 MAP3K11 MAPK3 MAP2K3 MAP2K1 PIK3R3 MAP2K2 PIK3CA ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260410%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology TMEM43 SMAD2 ADCY1 ADCY8 ADCY6 BANF1 NRAS ARHA MAPK1 HRAS ADCY9 MAPK3 EMD MAP2K1 MAP2K2 SYNE2 CTGF SYNE1 TGFB1 WWTR1 GRB2 KRAS SOS1 SOS2 ADCY3 LEMD3 SYNE4 SYNE3 SUN1 HEL-S-7a HEL-S-61 YY1AP1 PLEC SMAD4 HEL-S-15 LBR METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases LPL APOA2 SCARB1 PCSK9 APOE APOB LDLR ABCA1 ANXA2 MTTP APOC2 LIPG LIPC FRAGILE X SYNDROME%WIKIPATHWAYS_20260410%WP4549%HOMO SAPIENS Fragile X syndrome SHANK1 EPS8L1 PTEN ABAT MAP1B PRKAR1A PLCG1 CYFIP1 FMR1 PLCB1 RAP1GAP PPP2R5B CAMK1 ARAF SYNGAP1 NF1 HOMER1 TSC1 MAPK1 DICER1 DLG4 CDKN2A TARBP2 APP RHEB PPP3CA MAP2K1 AGO2 MAP2K2 BRAF GRB2 KRAS SOS1 DEPTOR RAF1 SH3GL3 EIF4A1 TSC2 CAMK4 DAG1 RPTOR AP2M1 MLST8 CPT1A CREB1 EPHA4 EEF1A1 MMP9 BDNF AP2A1 GAD1 FYN EIF4E AP2S1 PTPN11 MTOR CLTCL1 RPS6KB1 EIF4G1 PTPN5 GABRB2 ABCD3 GABRG2 ARC GRIA2 GRIP1 KCND2 TTI1 CLTC AKT1S1 CLTB CLTA GRIN2B CNR1 DKFZp762B153 NTRK2 GRIN1 AKAP5 SLC6A1 PRKCA ALDH3A2 SRC CYFIP2 SH3GL1 GRIP2 AGAP2 GPHN EIF4EBP2 ARHGAP32 KCNC1 DLGAP3 CAMK2A DUSP3 ALDH5A1 TBC1D7 HCN1 PICK1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260410%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway 5HT1A MAPKAPK3 MAPKAPK2 RAP1A HTR1E HTR1F HTR1D HTR1B ARHA MAPK1 STAT3 FOS MAP2K6 MAPK3 MAP2K3 RASGRF1 MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 PIK3CA PDPK1 GNAI3 GNAI1 HTR2A RPS6KA5 GNAO1 CREB1 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260410%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3R2 ROCK1 PIK3R1 MOB1A YAP1 TRIO ARHA MAPK1 TSC1 MTOR PKN3 PKN1 PIK3R3 PLCB4 PIK3CA PLCB3 PLCB1 PLCB2 TSC2 AKT3 PIK3CD TEAD2 LATS1 PKN2 LATS2 TEAD3 TEAD4 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260410%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 SLPI PTEN MST1R SMAD6 DUSP4 PIK3R1 SMAD2 SOCS3 SOCS1 RPS6KA3 PCNA KDR MTOR PLCG1 HK2 RPS6KB1 SMAD1 FGFR1 ITGB1 FLT1 ACACA SMAD9 CLDN5 CXCL1 TGFB1 IGF1R CXCL5 RPS6KA1 DKFZp781O1323 PDPK1 GSK3B PPARGC1A TNF MAPK8 HEL-S-133P IFNB1 CLDN1 IL10 HEL-S-102 CXCL2 PARP1 PRKAA2 CXCL8 TJP1 CCL2 MAPK1 FOS HEL113 MAPK3 IL6 SNAI2 JUN MAP2K1 MAP2K2 NFKB1 MAPK14 CSF3 CSF2 IBSP ACTA2 BGLAP GRB2 RAF1 CDH2 PDGFRA COL4A1 SP7 CRKL PRKCB FZD1 SIX1 RPS6KA4 CTNNB1 RPS6KA5 WNT10B ZEB2 SRC KLK15 IL1B CPT1A RELA RPS6 MAPK9 EGR1 NR0B2 VEGFA GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260410%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids DGAT1 PTDSS2 PTDSS1 DGAT2 CDS1 CHKB PCYT2 ETNK1 PEMT CHPT1 GPAM PNPLA2 DGKZ GPAT4 PISD PNPLA3 AGPAT4 PLA2G1B CDIPT ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260410%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome LMNA RCE1 FNTA HEL-S-62p ICMT LMNB2 CFD CELL CYCLE%WIKIPATHWAYS_20260410%WP179%HOMO SAPIENS Cell cycle CDK6 CHEK2 MYC SMAD2 CCNH CDC14B CDKN2B HEL2 CDC20 CDC23 PTTG1 PLK1 PTTG2 CDC2 CDC27 CDC25B ANAPC7 ANAPC5 ANAPC2 CDK4 ANAPC13 PKMYT1 CDKN2C ANAPC10 ANAPC11 ORC6 CDC6 ORC3 ORC2 STAG2 SMC1B DBF4 FZR1 CDKN2D WEE2 ANAPC1 CCND3 RBL2 MCM7 YWHAZ CDKN1A RBL1 YWHAQ E2F5 EP300 MCM3 MCM5 MCM6 CDKN2A CCNE1 CDK2 MDM2 STAG1 MAD1L1 CCNB1 WEE1 CDK7 RBX1 PCNA MAD2L2 TGFB1 ORC1L HDAC2 HDAC1 RB1 TFDP1 PRKDC TFDP2 E2F2 GSK3B TTK E2F3 CCNB2 HEL-S-1 CCND1 CDKN1C SMAD4 SKP2 SKP1 GADD45B ESPL1 GADD45A GADD45G CCND2 SFN CHEK1 YWHAG ATR CCNB3 E2F4 MCM2 CCNE2 RAD21 ATM CDC45 SMC3 SMC1A CDKN1B CCNA2 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260410%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM BLM CHEK2 ATF2 YAP1 BRCA2 CHEK1 PCNA RASSF1 H2AX BAK1 ATR RAD9A TRIM28 CDKN2A BAX FANCD2 MDM2 MCPH1 RIF1 MDC1 RNF8 RAD50 CDK5 MRE11A ATM BRCA1 NBN PRKDC SMC3 TP53BP1 TP73 SMC1A CASP9 TERF2 RAD51 RAD52 HSF1 RAD17 ACTL6A CASP3 LATS1 NABP2 KAT5 PARP1 APAF1 TRAF6 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2858%HOMO SAPIENS Ectoderm differentiation MYC TCF3 SOX2 SDCBP MKS1 GAS2L1 HDAC10 KRT6A KCNK10 POU2F2 MZF1 ASTN1 LY6E TFAP2C ARX STC1 ARHGAP15 ZBTB2 TRPM2 RHPN1 ST8SIA4 HESX1 ZBTB7B SHH SKIL GREB1 PRKAG2 PAN2 PTPRB PPFIBP2 MAFB LDB2 PLXNA2 WDR44 SIX6 GLI3 UBTF RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 ARHGEF9 KIFC3 BMP4 RUTBC3 STX16 RRBP1 CLVS1 CAP2 GLB1 TTC14 TNLG7C C1GALT1 VAX2 RIT1 ZNF219 CTNND2 MYORG BOC CTNNA2 PTPN13 RGMA CELSR2 DMD CDH8 CDH6 GATA6 TNFRSF11B H2BC9 ARHGDIG JUP FZD4 PIM1 ZFHX4 LHX1 CDON NUMA1 SMURF1 SCHIP1 PAX3 PAX6 TOX3 FYN NF2 OGT SOCS2 ZBTB16 SPRY2 BCOR FOXA2 NFATC1 CLDN11 HMGB2 AHI-1 NLGN1 SMAD4 FHL2 ELOVL4 CCL2 ROR2 CTBP1 SNCA PDE7A NLK NR2F2 NR1C2 WNT1 ELOVL2 TLE5 TFAP2A CTNNB1 TCF7L1 FZD5 FGFR2 TBL1X HDAC6 FZD8 BMPR1A SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260410%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260410%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAP2K5 PIK3R2 PIM2 PIK3R1 EIF4EBP1 EIF4A2 EIF4E EIF4B CSNK2A1 MAPK1 MTOR MAP2K6 MAPK3 RPS6KB1 EIF4G1 MAP2K3 MAP2K4 PIK3R3 MAP2K1 RPS6KB2 MAP2K2 MAPK14 PIK3CA MAPK10 RPS6KA1 EIF4A1 AKT3 MAPK8 PIM1 RPTOR RPS6KA2 RPS6KA4 PRKCA RPS6KA5 MAPK9 RPS6 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH NONO MDH2 NMRK2 CS SLC19A2 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260410%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease BBC3 NDUFB9 PRKAA1 NR1H3 PRKAB2 NR1C1 PRKAB1 DDIT3 PIK3R3 PIK3CA ADIPOR2 PRKAG1 PRKAG2 PRKAG3 COX4I2 CYP2E1 CXCL8 IKBKB NDUFA11 COX6A1 MAP3K5 COX6A2 COXFA4L2 NDUFC2-KCTD14 COX6B2 COX6B1 COX7A2L ERN1 UQCRC1 COXFA4 IL6 UQCRC2 UQCRB COX7A2 JUN COX7A1 UQCRH COX3 LEPR CYC1 ADIPOR1 COX7B2 UQCRQ COX7B COX4I1 ATF4 COX7C NDUFA9 CYB NDUFA5 MLX COX8A COX8C NDUFS8 UQCR11 UQCR10 COX5A NDUFA13 MLXIP IRS1 UQCRHL MLXIPL PIK3CD VCAM1 RAC1 IL1B PKLR NR1H4 NDUFA10 COX2 PIK3R2 PIK3R1 SOCS3 INS CDC42 INSR BCL2L11 ITCH MAP3K11 CEBPA SDHC SDHD SDHA SDHB TGFB1 LEP GSK3B TNF AKT3 MAPK8 CASP8 TRAF2 CASP3 NDUFA12 GSK3A EIF2S1 NDUFC2 NDUFC1 NDUFS6 IL1A NDUFS5 TNFSF6 NDUFS4 PRKAA2 NDUFS3 NDUFS1 FAS CYCS NDUFB8 NDUFB7 CCL2 NDUFB10 BAK1 NDUFB6 NDUFB5 NDUFB11 XBP1 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFV3 RXRA NDUFV2 BAX NDUFA7 NDUFA6 NFKB1 ZNF183 IL6R TNFRSF1A NDUFA3 NDUFA2 NDUFAB1 UQCRFS1 RELA MAPK9 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260410%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CAMK2G ATP2B1 CHRM2 HEL2 PRKAR1B PRKAR1A ADCY9 ANXA6 CACNB1 ITPR2 ORAI1 GRK5 CASQ1 GRK4 CACNA1S GNG12 GNG11 GNG13 RYR2 GNB2 GNAI3 GNB4 ADCY3 GNB3 GNAI1 GNB5 GNG2 YWHAZ GNAO1 GNGT1 GNB1 GNAS PRKD1 ATP2A2 CAMK1 YWHAQ ADCY1 ADCY8 ADCY6 GNG3 CACNA1C GNG5 GNG4 ATP1B1 GNG7 GNG8 FXYD2 RYR3 RYR1 ADRB2 CALM1 PLCB3 SLC8A1 CAMK4 RGS4 GJA1 RGS5 GJA3 RGS1 GJA5 GJA4 GJA9 GJA8 RGS6 RGS7 ATP1B3 ATP1B2 CACNB3 STIM2 CACNA1B CACNA1A GJC1 PKIB CHRM3 GJB2 CHRM1 GJB1 CHRM4 GJB4 CHRM5 GJB3 PKIA ADRB1 PKIG GJD2 CASQ2 PRKCZ RGS18 RGS17 RGS14 RGS16 ATP1A4 RGS20 KCNJ5 KCNB1 ATP2B3 ADRB3 CXNO ATP2B2 CXNA RGS11 RGS10 GJB6 FKBP1A HEL-S-1 ARRB2 RGS2 PRKCQ PLN SFN YWHAG GNAZ ADRA1D ADRA1B ADRA1A KCNJ3 PRKCH PRKCB PRKCE PRKCA HEL-S-99n CAMK2D CAMK2A GNA11 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 FUT2 FUT1 FUT3 B3GALT2 B3GALT1 HEPATITIS B INFECTION%WIKIPATHWAYS_20260410%WP4666%HOMO SAPIENS Hepatitis B infection MYC SMAD2 IFIH1 BAD MAVS VDAC3 RIGI PIK3R3 ATF6B PIK3CA YWHAZ CDKN1A MAPK13 YWHAQ ATF2 EP300 CXCL8 IKBKB ARAF IKBKG NRAS MAPK1 FOS HRAS MAP2K6 MAPK3 IL6 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 BRAF CREBBP MAPK14 MAPK12 MAPK10 ATF4 GRB2 KRAS SOS1 RAF1 SOS2 CREB3L3 CREB3L4 CREB3L2 IF1AA9 PIK3CD JAK1 CREB3 DDB2 TYK2 CREB5 CREB1 MMP9 IFNAR1 PIK3R2 NFATC2 PIK3R1 IFNA13 IFNA14 IFNA16 IFNA17 STAT4 PCNA IFNA10 STAT1 STAT2 STAT3 IFNA21 HSPG2 DDB1 IFNA1 BIRC5 TGFB1 NFATC1 TNF HEL-S-1 AKT3 CASP9 MAPK8 CASP8 TBK1 IRAK1 CASP10 CASP3 IKBKE CHUK SMAD4 IFNB1 FADD MAP3K7 IRAK4 TICAM1 TIRAP TGFBR1 TGFBR2 MAP3K7IP1 IRF3 APAF1 TRAF3 NFATC4 TRAF6 IRF7 NFATC3 TLR4 TNFSF6 MYD88 DDX3X BCL2 IFNA4 FAS CYCS IFNA7 IFNA6 IFNA2 IFNA8 BAX NFKB1 EGR2 TICAM2 TLR3 JAK3 CASP12 MAPK11 PRKCB PRKCA SRC RELA MAPK9 PTK2B STAT5B MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260410%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 ERBB2 GJB2 ERBB4 EGFR MYC USF1 ERBB3 PRLR EIF4E CSN2 CEBPA EIF4G1 CEBPB CLDN6 DLGAP4 TFPI2 BCL2L1 USF2 TTC9 TPM3 GAL NFIB ORAI1 HDGFL2 NR3A2 NR3C1 PTPN1 YY1 TNFSF11 CCND1 NRG1 PGR NFIA PRL CHUK ELF5 TNFRSF11A STAT5B NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260410%WP4747%HOMO SAPIENS Netrin UNC5B signaling IL1A NTN1 SELE ROBO4 YAP1 CCL2 FYN INPP5D ARHA KDR MAPK1 ALPL PTPN11 RGMA COL1A1 MAPK3 NTN3 JUN PTPA MAP2K1 ITGB4 MAP2K2 MAPK14 CTGF PIK3CA RLF PLEKHH1 UNC5B CIP2A NEO1 DCSTAMP MYF5 PPP2R1B RAF1 TNF PRKCA ARHGEF12 SRC CASP3 RAC1 VCAM1 AGAP2 PTK2B IL10 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260410%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP1 KCNN3 CALM1 SP3 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260410%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGF PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGW PIGV PIGY PIGX PIGC DPM2 PIGB PIGA PIGK PIGM MPPE1 PIGL PIGH BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260410%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX NDEL1 VLDLR IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260410%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia KIT ABCB1 GADD45A BCR MYC PIM2 ABCG2 PDGFRA CDKN1B LYL1 PIM1 FOXO3A CSF1R SKP2 GAB2 FLT1 NOP2 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260410%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR EGFR KRAS PTGS2 AKT3 PIK3CD NRAS MAPK1 PTGER4 PTGER1 SRC HRAS PTGER2 PTGER3 MAPK3 BRAF PIK3CA PLA1A INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260410%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC2H1 IFT140 IFT80 DYNLT3 WDR35 IFT43 IFT25 IFT22 DYNC2I2 DYNLT1 IFT81 DYNC1I1 DYNC1H1 IFT27 DYNLL2 DYNLRB2 IFT46 DYNC1LI1 DYNC1LI2 DNCL1 DYNLT2B DYNC2LI1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260410%WP2361%HOMO SAPIENS Gastric cancer network 1 INO80D UBE2C CENPF TOP2A HCTP4 LIN9 GATD3 H4C9 KIF15 SMOC2 ESM1 MYBL2 ECT2 KIF20B RUVBL1 AURKA NUP107 E2F7 ACTL6A S100P NOTCH1 H3F3B CEP192 APC LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260410%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAA2 LIPE HILPDA PRKAG1 ABHD5 AKT3 PRKAG2 PLIN1 PNPLA2 PRKAA1 PRKACG PRKAG3 PRKAR1B PRKAR1A PRKAB2 PRKAB1 ACSS2 PDHA1 FASN ACACA ACLY ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260410%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk KDR SRC RAC1 ROBO4 SLIT2 VEGFA 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260410%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDC2 PRKAA1 MTOR PRKAB2 RPS6KB1 PRKAB1 CDR2 RPS6KA1 PRKAG1 PRKAG2 PRKAG3 EEF2K EEF2 CDH18 MAPK13 PRKAA2 NDUFS3 RAB5IF MOSMO TRPM7 PDZD9 MAPK1 SDR42E2 VWA3A POLR3E UQCRC1 MAPK3 COXFA4 UQCRC2 UQCRB MAP2K1 CDK2 UQCRH MAP2K2 CYC1 MAPK14 MAPK12 UQCRQ CALM1 COX7C NDUFA9 CYB NDUFS8 UQCR11 UQCR10 COX5A MAPK11 RPTOR MLST8 UQCRFS1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260410%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H3C15 CDK6 UBE2D1 H4C9 HIST1H4L CDKN2B CDC23 RPS6KA3 CDC27 ANAPC7 UBB ANAPC5 ANAPC2 CDK4 CDKN2C STAT3 ANAPC10 UBC ANAPC11 HIST1H2AB UBE2S CEBPB FZR1 CDKN2D ANAPC1 H2BC15 RPS6KA1 RPS27A CDKN1A IL1A UBE2C CXCL8 MAPK7 H2AX MAPK1 FOS CDKN2A CDC26 VENTX MAPK3 ANAPC15 IL6 C10orf104 IGFBP7 JUN EHMT1 CDK2 NFKB1 H2AC19 H2AC14 H2BC26 H2BC12L H2BC21 H2BC9 H2BC8 H2AC6 UBE2E1 CDKN1B H2BC3 H2BC1 H2BC17 RPS6KA2 H2BC12 H2BC13 H2BC14 H2AC20 H2BC11 CCNA2 HIST1H2BE RELA H2AZ1 H2AZ2 H3C8 H3F3B H2AB1 H2AJ EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260410%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4F12 CYP4A11 NR1C1 PPARG CYP2C8 CYP4F2 CYP4A22 CYP2C18 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260410%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts ALDH18A1 CD36 PHGDH GLUD1 HEL-S-133P PSPH ARHA GLS UGDH FGFR4 BMP1 GCK PLCG1 P4HA2 FGFR1 P3H4 PLOD1 PSAT1 P3H3 LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway OXSM HTD2 MCAT MECR ACACA HSD17B12 BURN WOUND HEALING%WIKIPATHWAYS_20260410%WP5055%HOMO SAPIENS Burn wound healing FOXE1 MMP2 MMP9 BRD4 PECAM1 INHBA CXCL12 FGFR4 COL1A2 DCN FGFR1 CHRNA7 IL8RB KRT6A CXCL1 HMGB1 S100A6 TNF TIMP1 CASP3 IFNB1 HGF ACTA1 TLR4 MYD88 FGFR3 ACHE BCL2 CXCL8 NOX4 F13A1 IFNA2 CCL2 IL15 COL1A1 CD3E MMP28 EGF IL6 SNAI2 BAX NFKB1 HEXD DKFZp686P11128 KRT222 KLF4 S100A9 FST PCTK1 FLG SCEL AMBP HEL-S-43 SLURP1 LIN28A TPT1 IL1B FGFR2 CXCR4 TNC VEGFA FBN1 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260410%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling MAPKAP1 PTEN SMAD2 IGFBP5 MAP1LC3A EIF4E ACVR2B MTOR RPS6KB1 PRKAB1 TNLG5A ITGB1 NFKB1 TNFRSF1A GDF8 HEL-S-28 IGF1R DEPTOR GSK3B PPARGC1A IGF1 IRS1 RPTOR TRIM63 FBXO32 WASL MLST8 AKT1S1 RICTOR EIF2B2 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling PLK1 MAP3K8 CISH PIK3R3 PIK3R5 PIK3CA CXCL11 CXCL9 MAPK13 CXCL8 IKBKB IKBKG CCL3 MAPK1 FOS MAP2K6 MAPK3 IL6 MAP2K3 MAP2K4 JUN MAP2K1 MAP2K2 MAPK14 MAPK12 MAPK10 ZMYND11 IF1AA9 PIK3CD MLST8 RAC1 IL1B IFNAR2 MBL2 IFNAR1 SMAD6 PIK3R2 PIK3R1 IFNA13 IFNA14 IFNA16 IFNA17 SOCS1 IFNA10 STAT1 IFNA21 NFKB2 PTPN6 IFNA1 IRAK2 TNF RNF41 AKT3 TNFAIP3 TREM1 MAPK8 CASP8 SYK TBK1 IRAK1 IKBKE CHUK IL12B IFNB1 IL12A FADD IRAK3 MAP3K7 IRAK4 TICAM1 TLR1 BTK TIRAP TIFA NFKBIA TLR9 TLR8 MAP3K7IP1 IRF3 TRAF3 TLR7 TRAF6 IRF7 TLR5 TLR4 OTUD5 MYD88 SQSTM1 IFNA4 CYLD IFNA7 IFNA6 IFNA2 CCL5 IFNA8 CCL4 TMED7 RBCK1 NFKB1 RIPK1 CD40 CD80 LBP TICAM2 TLR3 LY96 SPP1 CD14 TAB3 MAPK11 FBXW5 CD180 TRAFD1 SIGIRR CUEDC2 SFTPD RELA PELI1 MAPK9 RNF31 SFTPA2 PELI3 SARM1 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260410%WP3972%HOMO SAPIENS PDGFR beta pathway GRB2 PIK3R1 SOS1 RAF1 EIF2AK2 MAPK8 PRKCB STAT1 PRKCA STAT3 FOS HRAS PLCG1 JAK1 MAPK3 MAP2K4 JUN MAP2K1 STAT5B MAP3K1 PIK3CA 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome MARF1 DCP1A ACTR10 PLAGL1 ABCC1 DCP2 RAPGEF4 RAP1A PLK1 OFD1 CEP20 PAFAH1B1 DISC1 KIAA0753 GATA3 DCTN6 DCTN1 DCTN4 PLAG1 PCM1 CEP170 ACTR1B BMERB1 NDE1 ABCC6 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260410%WP1422%HOMO SAPIENS Sphingolipid pathway CERK PLPP1 SGMS1 SPHK2 SPTLC1 SPHK1 ASAH2 SGMS2 GBA2 SGPP2 ACER1 SPTLC3 UGCG SPTLC2 SERINC1 SGPL1 CERT1 KDSR CERS5 UGT8 CERS6 CERS2 PPP2CA CERS3 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260410%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway FGF7A KIT WNT2B INHBA INS NTF4 LEFTY1 IL3 KITLG FLT3LG EGF IL6 ALK FGF10 DKK1 FGF2 IL6R TGFB1 NT5E TF CSF1 FGF8 TNFSF11 EPO NOG FST IGF1 PDGFA SHH CNTF WNT1 CXCR1 CSF1R NOTCH1 WNT3A IL11 HGF WNT7B GDF5 NODAL TPO VEGFA BMP4 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260410%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260410%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PTEN MAPKAPK2 ROCK1 NTRK3 CDC42 LIMK1 CDC2 TAOK1 MAPRE1 PHLDB2 TRIO MAP1B NTRK1 NTRK2 STAT3 CFL2 F2RL2 TIAM1 MARK1 PARD6A GSK3B DVL1 CAMK4 PAK1 RHO FREP1 EPHB2 PRKCA AURKB SRC RAC1 SPRED1 WNT3A CLASP1 APC HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260410%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway KEAP1 SLC11A2 PRKAG1 PDHA2 HEL-S-133P PRKAA1 HIF1A PRKAB1 RPS6 PDHA1 ACACB ACACA NFE2L2 EGLN1 VEGFA CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260410%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CD8B1 CALM1 HDAC2 NFATC2 HDAC1 EP300 PPP3CC ITPRIP MEF2D CABIN1 CD8A PLCG1 ATP2A1 PPP3CA ZAP70 LCK JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 PARP11 STAT3 DTX3L BTRC HDAC2 PARP14 SKP1 RBX1 PARP1 STAT1 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260410%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders FGF7A WWTR1 H4C9 HIST1H4L SOX2 SOX4 SOX11 POU3F2 SRRT SOX12 TEAD2 POU3F1 UTF1 SOX15 ZSCAN10 YES1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260410%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 WNT SIGNALING%WIKIPATHWAYS_20260410%WP428%HOMO SAPIENS Wnt signaling CAMK2G NOTUM MYC PPP3CC DAAM2 PRICKLE2 GPC4 PLCB4 PLCB1 CCND3 PLCB2 VANGL1 PPP3R2 DAAM1 ROCK2 JUN PPP3CA PORCN LRP5 LRP6 PLCB3 RAC1 LEF1 NFATC2 ARHA PPP3R1 NFATC1 GSK3B CCND1 MAPK8 WNT3A MAP3K7 AXIN1 DKK4 NFATC4 APC NFATC3 WNT2B CHD8 FZD10 FRAT1 FRAT2 CCND2 SOX17 SOST CER1 INVS WNT5B CSNK2A1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E WNT16 SENP2 DKK1 DKK2 SFRP4 SFRP1 SFRP5 CSNK2B ROR1 ROR2 CTBP2 CTBP1 NLK CXXC4 NKD1 NKD2 WIF1 DVL1 DVL2 DVL3 WNT1 PRKCB WNT3 FZD1 PRKCA CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 MAPK9 WNT4 CSNK1A1 CAMK2D RYK WNT7B FZD7 CAMK2A FZD9 WNT7A FZD8 FOSL1 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5393%HOMO SAPIENS Androgen biosynthesis POR HSD3B2 CYP3A7 HSD17B1 HSD17B2 HSD3B1 HSD17B3 HSD17B4 HSD11B1 HSD11B2 SULT2A1 SRD5A2 CYP17A1 AKR1C1 AKR1C2 AKR1C4 CYP3A4 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260410%WP727%HOMO SAPIENS Monoamine transport and regulation SYN1 ACHE TPH2 DBH ADORA2A SLC6A2 SLC6A3 HRH3 MAPK14 SLC5A7 AMPH IL1R1 NECTIN2 TDO2 SLC6A1 TNFRSF11B ITGB3 TGFB1I1 TNF RBL2 TSC2 FBXO32 STX1A IL1B UNC13B TH IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260410%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL1A STAT2 STAT3 HEL-S-10 JAK1 IL6 IL10RB IL10RA IL10 HMOX1 STAT1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence SLCO2A1 ALOX5 PTGS2 ALOX15B DECR1 PTGES3 ALOX5AP FADS1 SIRT1 PTGIS PTGS1 ALOXE3 AKR1B1 EPHX2 CYP4F8 HEL-S-53e NAT2 PTGES PRXL2B RB1 HEL-S-298 HPGD ALOX15 FADS2 ALOX12 ELOVL5 GPX1 ELOVL2 MAPK11 LTC4S HEL-S-22 CDKN1A DPEP2 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260410%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors LAMC1 LAMA4 XB SDC2 COL4A2 COL4A1 ITGA1 THBS2 COL1A2 COL3A1 COL5A3 LAMB2 COL5A2 ITGB5 THBS1 COL6A1 ITGB6 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260410%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCC CYB UQCC3 UQCC2 UQCR11 UQCR10 TTC19 LYRM7 UQCRC1 UQCRFS1 UQCRC2 UQCRB UQCRH CYC1 UQCRQ GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260410%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation NFATC1 PLCB3 PRKCZ PPP3CC PRKCH PRKCB PRKCE PRKCA PRKCI ANGPT2 PKN2 PRKCQ PRKD3 PKN3 PPP3CA PKN1 PPP3R2 PPP3R1 PRKD2 PRKD1 PDGF PATHWAY%WIKIPATHWAYS_20260410%WP2526%HOMO SAPIENS PDGF pathway PIK3R1 CDC42 STAT1 ARHA MAPK1 STAT3 PTPN11 FOS HRAS TIAM1 PLCG1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 NFKB1 GRB2 SOS1 RAF1 PDGFA MAPK8 PAK1 WASL SRC RAC1 JAK1 CHUK VAV1 NFKBIA COX2 VAV2 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260410%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ALDH18A1 HEL-S-20 HEL-S-29 GLUD1 ARG1 HEL-S-5 ASL NAGS ASS1 SMS SRM OTC ARG2 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260410%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1C3 SULT1C2 SULT1B1 SULT6B1 UGT1A10 SULT1A4 SULT1A2 UGT1A9 SULT1C4 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT1A5 UGT2B4 UGT2A2 UGT2A1 CYP4F8 NAT2 NNMT TPMT INMT HEL-S-75 CYP4Z1 CHST6 CYP2U1 CYP4F22 CYP4X1 CHST10 NAA50 CHST11 CYP2J2 GATF-C GLYATL2 CYP4F11 CYP27C1 AKR1B10 NAT8 CYP2S1 CYP11B2 NAT9 NAA40 CYP21A2 NAT10 AKR1C1 NAT14 AKR1C2 LOC51064 AKR1C4 CYP4V2 CYP3A4 HYAL3 GSTM1 CYP2R1 GAL3ST3 UGT1A3 FMO4 EPHX1 GAL3ST4 FMO5 CHST8 CYP1B1 CYP2E1 CHST9 KCNAB1 KCNAB3 CYP2A7 CHST4 CHST5 NAA20 CYP2F1 HS3ST5 HS3ST6 HS3ST4 GSTZ1 CYP1A1 CYP20A1 CYP46A1 SULT2A1 CYP3A43 UGT1A4 CYP2A6 AKR1B1 SULT2B1 SULT1A1 UGT1A1 GSTM4 GSTM3 GSTM2 GPX2 GSTM5 GPX4 GPX3 CYP3A7 CYP51A1 HEL-75 CYP26C1 CYP27B1 GSTT2 CYP24A1 CYP17A1 GAL3ST2 NAT8L HS3ST3A1 EPHX2 HS6ST1 HS6ST2 HS2ST1 HS6ST3 CHST12 NDST3 BAAT CHST13 CHST14 CYP7B1 HS3ST3B1 CYP8B1 CYP27A1 CYP11A1 CHST7 UGT1A7 HS3ST1 HS3ST2 MGST3 CHST1 CHST3 MGST1 CYP4F3 MGST2 GSTT2B CYP2C9 CYP2C8 CYP2B6 CYP2C19 CYP2C18 HEL-S-75p CYP26A1 CYP26B1 CYP7A1 GSTA5 GSTA4 GSTA3 CYP2W1 HEL-S-166mP CYP2A13 CYP4B1 CYP4F2 HEL-S-64p CYP4F12 HEL-S-21 HEL-S-22 SULT1E1 UGT2B7 HEL-S-165mP SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260410%WP1455%HOMO SAPIENS Serotonin transporter activity IL1R1 STX1A IL1B TPH2 ITGB3 TGFB1I1 MAOA PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260410%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS NCK1 TLN1 VTN PCNA FYN CTSL SCARB2 CD151 PTPRO PLCE1 PARVA LMX1B PLCG1 SYNPO ITGB1 TRPC6 ITGB4 PAX2 CD2AP MYO1E HEL-S-28 INF2 TGFB1 NPHS1 NPHS2 MYH9 IRF6 FAT1 ITGAV CDKN1C CDKN1A CLDN1 MME TLR4 LAMA5 YWHAQ SMARCAL1 MKI67 AGRN KIRREL3 KIRREL2 HEL113 PLAUR LIMS1 LAMB2 DKK1 LRP5 LRP6 ACTN4 CD80 ITGB3 CDH2 CDKN1B WNT1 COL4A4 DAG1 COL4A3 WT1 CTNNB1 COL4A5 NOTCH1 HEL114 CR1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260410%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260410%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS DPYD UMPS TYMP DHFR CES2 ABCG2 CES1 CDA FPGS TYMS UPP2 SLC22A7 TK1 ABCC5 GGH UCK2 CYP2A6 UCK1 XRCC3 ABCC3 TDG RRM2 ERCC2 SMUG1 SLC29A1 RRM1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260410%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAA2 RHOD RHOB MOB1A YAP1 PRKAG1 PRKAG2 RHO ARHA PRKAA1 PRKAG3 PRKAB2 LATS1 TEAD2 STK4 LATS2 HMGCR PRKAB1 TEAD3 TEAD4 CYR61 CTGF GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260410%WP4521%HOMO SAPIENS Glycosylation and related congenital defects SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 ALG11 DPM1 GMPPB DPM3 MGAT2 GCS1 MPDU1 MAGT1 TUSC3 DPM2 ALG1 DPAGT1 ALG8 ALG9 B4GALT1 ALG6 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260410%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC3 CYP2E1 ATF2 HDAC7 DHFR HDAC5 TYMS ACSS2 HDAC10 ADH1A HDAC2 HEL-S-53e HDAC1 MTR MAT1A ADH1C ALDH1A3 HEL-S-117 HAT1 ALDH2 KAT2B HDAC8 ALDH1A2 HDAC9 HDAC6 SLC19A1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP26%HOMO SAPIENS S1P receptor signal transduction S1PR2 PLCB3 S1PR5 PLCB1 SPHK2 PLCB2 SPHK1 MAPK7 PIK3C2B GNAI3 GNAI1 AKT3 S1PR3 MAPK1 MAPK4 MAPK3 SMPD2 S1PR1 MAPK12 MAPK6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260410%WP4595%HOMO SAPIENS Urea cycle and associated pathways GOT2 SLC25A12 HEL-S-32 GLUD1 NOS2 SLC25A15 LDHB GLS2 ARG1 ASL NAGS ASS1 SLC25A13 FH GPT OTC MDH2 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260410%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 FBL MAFG IRF2 HEL23 SMAD4 FOXO1 PCNA CREB1 NPAS2 CREBBP DDX21 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members ARAF MAP3K10 MAP3K5 MAPK1 MAP3K8 MAP2K6 MAPK3 MAP3K11 MAP2K3 MAP2K4 MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 MAPK12 TNKS MAPK10 ATF4 PARP14 RAF1 MAP3K12 MAPK8 MAPK11 MAP3K21 MAPK9 MAP3K7 PARP1 MAPK13 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases D2HGDH HEL-S-5 GCDH ADHFE1 L2HGDH MDH2 ALDH7A1 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260410%WP5031%HOMO SAPIENS Biotin metabolism including IMDs MCCC2 BTD PCCA HLCS ACACB MCCC1 ACACA PCCB PC HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260410%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260410%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling SAR1A CDK8 RNF139 SEC23B SEC31B SEC31A AMFR SEC24C INS CAMP SP1 PRKAA1 HMGCS1 MTOR PRKAB2 PRKAB1 HMGCR MED15 SREBF2 SCD FASN ACACA ACLY SAR1B PIK3CA PPARG HEL-S-32 SEC23A PPARGC1B PRKAG1 PRKAG2 PRKAG3 GSK3A NFYA LPL PRKAA2 SCARB1 DBI FGF21 LDLR SIRT1 INSIG1 ACSS1 NR1H2 YY1 IDI1 MBTPS1 FDPS GPAM CYP51A1 SQLE MVD MBTPS2 LPIN1 FDFT1 CREB1 RBP4 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260410%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 XDH CYP2A6 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260410%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC8 EXOC2 RAC1 HRAS KRAS YBX3 RALA CDC42 RAC3 NRAS RALBP1 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer SLC16A4 LDLR PDHX GLUD1 BCAT2 GFPT1 PGM3 HK2 SOAT1 HMGCR GNPNAT1 FASN ACLY CS CARM1 RPIA RPE PFKL KRAS GOT2 DLD ME1 HEL-S-32 HEL-S-30 HEL-S-133P GLS2 DLAT GPT PDHA1 SLC7A5 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260410%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NOD1 NLRC4 IKBKB NAIP MEFV CASP5 IKBKG NLRP7 NLRP2 NLRP1 AAMP CARD8 CARD9 DUOX2 CARD6 ACAP1 AIM2 NLRP10 ERBIN NOD2 PRDM1 PYCARD NLRP12 COPS6 NDUFA13 IL18 CASP9 CASP8 RAC1 CHUK IL1B RELA NFKBIA NLRP3 RIPK2 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260410%WP5572%HOMO SAPIENS Nucleosome remodeling complex ASF1A CHEK2 SUPT16H H4C9 HIST1H4L PRKDC SSRP1 SMIM40 RBBP4 NASP PCNA CHAF1A HAT1 XRCC5 CHAF1B ASF1B MCM2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD6 SMAD2 INHBA STAT1 RUNX3 STAT3 SMAD1 ZFYVE9 BAMBI ITGB6 SMAD9 TGFB1 DKFZp781O1323 FKBP1A ZNF423 TNF SKIL SMAD4 TGFBR1 TGFBR2 LIF TGFBR3 BMP4 EP300 SKI LEFTY1 LEFTY2 FOS HRAS MAPK3 EGF THBS1 RUNX2 JUN FOXH1 NFKB1 CREBBP NOG FST SPP1 WNT1 TGIF1 CTNNB1 ZEB2 JAK1 IFNG LEF1 MAPK9 LTBP1 ENG NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2064%HOMO SAPIENS Neural crest differentiation RBPJ GJB1 HES5 DLX5 TBX6 MYC PAX3 MSX2 HAND1 NOTCH2 NOTCH3 NFKB2 SMAD1 ZIC5 FGFR1 ITGB1 HDAC11 HDAC10 DMBX1 FOXD3 MSX1 MIA OLIG3 BMP7 SOX10 TFAP2B PHOX2B ZIC1 DCT HOXB1 HDAC2 PRTG HDAC1 LHX5 PAX7 NEUROG1 GSK3B COL11A2 GBX2 FGF8A WNT3A AXIN1 ASCL1 HDAC9 ISL1 GFAP BMP4 TCF4 HDAC3 COL2A1 RHOB SNAI1 MPZ FGFR3 PMP22 HDAC7 ID1 HDAC5 TLX2 OLIG1 OLIG2 TWIST1 MBP AXIN2 SNAI2 HOXA1 FGF2 NFKB1 CDH6 CTBP2 FGF8 CDH2 SOX5 DVL1 DVL2 DVL3 MYB WNT1 HEY2 TFAP2A CTNNB1 SOX9 HDAC8 FZD3 LHX1 TCF7L1 NOTCH1 FGFR2 WNT8A DLL3 HDAC6 DLL4 HES1 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260410%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C1 CD36 CYP2C9 NR1C2 NR1i1 NPC1L1 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TGFB1 TLR4 CD80 IL2RG IL4 SOCS1 CCL5 CCL2 IL2RA IL2RB STAT3 CTLA4 NFKB2 IRAK4 PDCD1 TGFBR2 TLR8 NFKB1 TLR7 TRAF6 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260410%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism FFAR3 GCG SLC2A4 PYY FFAR2 NR1C2 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260410%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation CXCL8 IKBKB IKBKG PLCG2 MAPK1 PLCE1 PLCG1 MAPK3 IL6 RETN NFKB1 MAPK14 PLCB4 PIK3CA PLCB3 PLCD3 PLCB1 PLCB2 PLCD4 TNF AKT3 PIK3CD CHUK IL12B RELA IL12A NFKBIA AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260410%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension HAL UROC1 GPT2 FTCD GLUD1 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260410%WP143%HOMO SAPIENS Fatty acid beta oxidation LPL ECHS1 LIPE ACADL GPD2 ACSL3 DECR1 ACSL1 ACSL6 ACSL5 PNPLA2 ACSS2 LIPC FACL4 ACADVL LIPF ACADS CHKB DLD ACAT1 CRAT CPT2 SLC25A20 HADHB GCDH ACADM CPT1A HEL-S-49 IL4 SIGNALING%WIKIPATHWAYS_20260410%WP395%HOMO SAPIENS IL4 signaling PIK3R2 ATF2 PIK3R1 EP300 CBL SOCS3 SOCS1 BAD IKBKB INPP5D STAT1 MAPK1 STAT3 PTPN11 FOS MAPK3 RPS6KB1 CEBPA PTPN6 CEBPB NFKB1 MAPK14 PIK3CA FES GRB2 SOS1 IL2RG FLNA IL4 JAK3 IRS1 PIK3CD SOCS5 MAPK11 JAK1 CHUK RELA TYK2 GAB2 NFKBIA STAT5B PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5103%HOMO SAPIENS Progeria associated lipodystrophy TGFB1 FFAR3 SMAD2 PPARG ZMPSTE24 FNTA INS BANF1 ICMT LMNB2 MUCL3 SPRTN WRN SMAD4 LMNA RECQL PARP1 FBN1 KCNJ6 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260410%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis ARHGEF1 TBXA2R PTGS1 GNA13 ARHA CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260410%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT MTOR PRKAB2 SIRT1 IGF1 PPARGC1A JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260410%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells EPOR SOCS3 SOCS1 CCND2 PRLR NRAS STAT1 CDK4 STAT3 HRAS MTOR SOCS2 CISH IL6 IL6R FOXM1 CCND3 GHR KRAS EPO AKT3 RPTOR GH1 MLST8 IFNGR1 PRL IFNGR2 IFNG AKT1S1 STAT5B ARYLAMINE METABOLISM%WIKIPATHWAYS_20260410%WP694%HOMO SAPIENS Arylamine metabolism SULT1A1 NAT2 UGT1A9 SULT1A2 UGT1A4 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260410%WP185%HOMO SAPIENS Integrin mediated cell adhesion CRK MAP2K5 PIK3R2 ROCK1 TLN1 RAP1A CDC42 FYN VASP CAV3 MAPK4 ITGB5 ITGB1 SHC3 CAPN3 ITGB4 ITGB8 ITGB7 ITGB6 HEL-S-28 ITGA7 DOCK1 PDPK1 ITGAM ITGAV ZYX AKT3 ITGA4 ITGA2 PAK1 RHO ITGAE MYPN ITGA1 CAPN9 CAPN6 ITGAX CAPN7 CAPN5 TNS1 GIT2 CAPN11 CAPN10 ITGA6 VAV3 VAV2 ROCK2 CAPNS1 MAPK7 RAC3 PAK6 ARAF MAPK1 PAK4 CSK HRAS ARHGEF7 MAP2K6 MAP2K3 MAP2K1 MAP2K2 BRAF MAPK6 MAPK12 MAPK10 GRB2 SOS1 RAF1 ITGB3 ITGA2B RAC1 SRC PXN MYLK2 SELENOP HEL114 CAV2 RAPGEF1 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260410%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGFR BDNF RAF1 NTRK2 HTT RPS6KA5 MAPK1 CASP3 HRAS MAPK3 EGF MAP2K1 MAP2K2 CREB1 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260410%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition CDH6 SNAI1 SMAD2 CDH2 ID1 AKT3 MAPK1 HEL113 SMAD4 MAPK3 SNAI2 RUNX2 TNC CDH16 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260410%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer MAPKAP1 PTEN PIK3R1 EIF4EBP1 ARAF NRAS MAPK1 TSC1 HRAS MTOR MAPK3 RPS6KB1 MAP2K1 MAP2K2 INPP4B BRAF PIK3CA GRB2 KRAS SOS1 DEPTOR RAF1 SOS2 PARP2 TSC2 IRS1 AKT3 RPTOR MLST8 AKT1S1 RICTOR PARP1 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260410%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MMP9 STAT1 RUNX3 ALPL HMGCS1 FGFR1 TGFB1 BMP7 IGF1R IGF2 IGF1 CDKN1C PTCH1 FRZB IHH CHST11 GLI3 THRA PTH1R PTHLH COL2A1 ACAN FGF18 FGFR3 ENPP1 KIF3A RUNX2 FGF2 CALM1 ADAMTS4 GHR PTH ADAMTS5 COL10A1 TIMP3 PLAT SOX6 NKX3-2 SOX5 SPP1 DDR2 CAB39 CST5 SCIN BMP6 GH1 MGP SOX9 MEF2C STAT5B VEGFA BMPR1A TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260410%WP2113%HOMO SAPIENS Type III interferon signaling STAT2 IRF9 JAK1 IFNL2 IL10RB IFNLR1 TYK2 IFNL3 IF1IB1 STAT1 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260410%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis GATA3 EGR2 PPARG CEBPA KLF15 KLF2 CEBPB KLF5 DDIT3 GATA2 CEBPG CEBPD OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260410%WP5574%HOMO SAPIENS Oligodendrocyte development OPALIN ZBTB33 HES5 TMEM98 CNTN1 NFATC2 CHD8 SOX2 ID2 SOX11 OLIG1 OLIG2 MBP BMP1 NKX6-1 SMAD1 FGF2 NKX2-2 SOX10 EGR2 RELN SOX6 SOX5 PDGFRA SHH ID4 PRKCA SOX8 NFIA SOX9 TCF7L2 ZEB2 WNT10A CSPG4 MYRF ASCL1 PTN ZNF24 DUSP15 ZNF488 LGI1 NKX2-6 MYT1 BMP4 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260410%WP2001%HOMO SAPIENS miR targeted genes in adipocytes LPL SRSF10 TMED10 CYP1B1 TMEM43 ELOVL5 SRSF9 CAP1 PHC2 IGF2R FADS1 CEBPB PICALM TGFBR2 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260410%WP45%HOMO SAPIENS G1 to S cell cycle control CDK6 MYC CCNH CDKN2B CDK7 CDC2 PCNA CDK4 CDKN2C ORC6 ORC3 ORC2 ATF6B CDKN2D ORC1L CCND3 RB1 TFDP1 TFDP2 E2F2 E2F3 CCND1 CDKN1C MCM7 CDKN1A CCNG2 PRIM2 GADD45A MNAT1 POLA2 CCND2 RPA3 MCM3 RPA1 MCM5 MCM6 CDKN2A CCNE1 CDK2 MDM2 MCM2 PRIM1 CCNE2 CDC45 ATM CDKN1B CREB3L3 CREB3L4 POLE CREB3 CCNB1 POLE2 CREB1 MYT1 WEE1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5406%HOMO SAPIENS 13q12 12 copy number variation MIPEP LINGO1 C1QTNF9 ATXN1 SGCD CDC42 SGCB SACS SGCG TNFRSF19 C1QTNF9B ARHA SPATA13 SGCA DMD SSPN TRAF1 TRAF5 SNTB1 RTN4 MAPK8 RTN4R DAG1 SNTA1 TRAF2 RAC1 MAPK9 TRAF3 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260410%WP3945%HOMO SAPIENS TYROBP causal network in microglia NCKAP1L IL13RA1 PLEK CXCL16 RUNX3 SH2B3 HEL-S-66 RPS6KA1 PYCARD MAF ITGAM NCF2 ITGAX TYROBP C1QC TGFBR1 HCLS1 GAL3ST4 DPYD TNFRSF1B CD84 NRROS FKBP15 SLC7A7 LOXL3 TCIRG1 PPP1R18 ZFP36L2 CD37 RNASE6 LGALS9C NPC2 IL10RA APBB1IP BIN2 ELF4 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ADAP2 HLX CYTL1 LHFPL2 HIMAP2 GAPT LYL1 SPP1 IL18 CREB3L2 GPX1 RGS1 HEL-S-62p INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260410%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC3 NFATC3 NFATC2 EP300 HDAC7 HDAC5 NELFCD CDK9 PPP3CC SP1 NELFB NELFA PPP3CA PPP3R1 NFKB1 CREBBP NFATC1 HDAC2 HDAC1 SUPT4H1 HEXIM1 SUPT5H HDAC8 RELA HDAC9 PPP3R2 NFKBIA NFATC4 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5153%HOMO SAPIENS N glycan biosynthesis DDOST RPN1 FUT8 TUSC3 ALG1 MGAT1 MPDU1 DPM2 B4GALT2 B4GALT1 RFT1 DPAGT1 ALG8 ALG9 ALG6 SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 ALG11 DPM1 GMPPB DPM3 MAN1A2 MGAT2 MAN1A1 GCS1 ST6GAL1 ST6GAL2 ALG5 ALG10 MAN1B1 ALG10B GANAB MAN2A2 MAN2A1 MGAT5 MGAT5B MGAT3 MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B STT3A RPN2 STT3B LAC PHE PATHWAY%WIKIPATHWAYS_20260410%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260410%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer RPH3A RAB27A SYTL1 RAB27B MYRIP SYTL5 UNC13D TBC1D10A SYTL2 MLPH EXPH5 MADD GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260410%WP455%HOMO SAPIENS GPCRs class A rhodopsin like BRS3 MC4R CCKAR GHSR LHCGR TBXA2R NPY5R AVPR1B NPY1R HRH3 PTGIR OPRM1 AVPR1A SSTR3 SSTR4 FPRL2 TRHR SSTR5 OPRD1 NPY4R OPN1SW FPR1 OPN1MW MC2R GALR3 OPN1LW GALR2 GALR1 NTSR2 RHO NMBR MC1R MC5R CMKLR1 CCKBR MGRA OR1G1 F2RL2 GRPR OR1F1 OR2H1 GPR15 OR3A3 OR10A5 OR3A1 PTGFR OR1E1 C5AR2 GPR83 CXCR4 OR2B6 NTSR1 P2RY13 GPR17 P2RY11 OR2F1 OR2A4 GPR18 OPN4 OPN3 FFAR2 MC3R GPR68 NPFFR1 CNR1 MTNR1A P2RY6 P2RY4 P2RY2 P2RY1 P2RY10 P2RY14 ADORA2A ADRA1D GPER ADRA1B ADRA1A DRD2 DRD3 DRD4 CHRM2 NPFFR2 RRH GPR174 GPR173 GPR171 CMKLR2 GPR37L1 OR1I1 NPBWR2 OR6B1 OR2J3 OR2J2 OR2J1 RGL4 OR6A2 OR7C2 OR7C1 GPR19 IL8RB OR10J1 GPR27 GPR25 PTGDR2 GPR22 FFAR1 CCR10 GPR39 OR5F1 CCR1 GPR37 XCR1 GPR34 GPR32 CCR5 GPR31 OR5V1 OR3A2 OR10H1 OR10H3 GPR45 OR10H2 GPR42 HTR2A MAS1L OR2AG1 CHML CXCR1 GPR52 GPR50 GPR4 SSTR2 GPR3 GPR6 F2RL1 CCR8 OR1C1 CCR7 GPR65 CCR6 GPR63 CCR4 CCRL2 CCR3 OR2D2 CCR2 GPR75 OR2T1 OR1A2 OR1A1 OR2C1 5HT1A SUCNR1 CX3CR1 OR5I1 AGTR2 GPR87 CXCR5 MCHR1 OR2S2 HCAR3 OR1Q1 HCAR1 OR2B3 OR2B2 NMUR2 NMUR1 OR7A10 OR14J1 CXCR3 MLNR PRLHR OR8D2 OR7A17 OR7A5 OR10A4 OR1E2 CNR2 OR8B8 OR2W1 OR12D3 OR1D5 OR1D2 OR2F2 ACKR4 ACKR2 ADRB2 OR11A1 KPG_010 AGTR1 AVPR2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B ADRB1 HRH1 HRH2 DRD5 HTR1E F2R HTR1F HTR1D OPRK1 HTR1B ADRA2C HTR5A ADRA2B ADRA2A ADRB3 ADORA2B FFAR3 OXTR NPY2R GPR85 DRD1 PTGDR EDNRA FSHR EDNRB HCRTR2 HCRTR1 MTNR1B LPAR4 PTGER4 PTGER1 PTGER2 ACKR3 PTGER3 HTR4 HTR6 HTR7 F2RL3 FPR2 GPR161 BDKRB2 BDKRB1 LTB4R KPG_011 C3AR1 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5366%HOMO SAPIENS NF1 copy number variation syndrome H3C15 MCL1 JARID2 H4C9 HIST1H4L MAVS ARF6 PCNA RIGI ARHA EXOC7 NGFR SDC2 OMG RBBP7 RAD51 EED RTN4R NGF IFNB1 TUBB SYN1 EXOC8 ROCK2 EGFR BCL2 LIMK1 EXOC4 EXOC3 EXOC6 NF1 EXOC5 MAPK1 ATR EXOC2 SUZ12 RAD9A EXOC1 MAPK3 MAP3K2 EGF CCNE1 HOXA1 CRY1 MAP3K1 USP1 WDR48 PER1 HOXA9 CCNE2 EVL ADAP2 INPP5A E2F6 RAB11FIP4 SOS1 TEFM RAF1 UTP6 ATAD5 COPRS EVI2A SUPT5H CRLF3 POLRMT EVI2B EIF3A EZH1 METAP2 RFC3 RFC4 RAB11A CCNA2 RFC2 H3C8 HEL-S-15 MYT1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260410%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NAMPT FOXO3A SIRT1 PPARG HIF1A SIRT3 ROS1 FOXO1 PARP1 TFAM NFKB1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260410%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction ACVRL1 EPOR IL18RAP IL18R1 TNLG5A TNFRSF10B TNFRSF4 TNFRSF18 NGFR TNLG2B BMP8B TNFRSF14 IL10 CXCL2 BMP4 LTB TNLG7A CXCL8 TNFRSF25 IL9 IL9R TNFRSF10C IF2B1 IL23R IL25 IL27 IL34 IL6 IL-21 IL27RA IL21R TNFSF10 IL17F IL17A CSF3 CSF2 IL17D IL17C CSF1 IL17B EPO IL18 GDF3 CSF1R CXCR4 NODAL BMP5 ACVR1B TPO CCL4L2 CXCL17 IF2D IF2G IL36A IL36B IL36RN TSLP IL36G IFNW1 IL1F10 IL3 CXCL12 CXCL6 IL24 IL5 IF1IB1 PF4V1 IL19 CD40LG XCL2 IFNK CCL14 CCL13 IFNL2 CCL18 IFNL3 IL33 CCL23 IL31 IL37 BMP7 CXCL1 LEP CXCL5 LTBR CNTF IL1R2 NGF IFNB1 IFNLR1 BMP10 LIF CNTFR ANP32B CCL5 PRLR TNFRSF1B CCL4 LTA CCL2 TNFRSF19 BMP3 IL10RB IL10RA IL1RL2 GDF10 CD40 IL6ST GDF11 CXCL13 CXCL14 CXCL16 TNFRSF10A IL8RB CCR10 CCR1 XCR1 PPBP CCR5 CXCL11 CXCR1 CXCL9 CXCL3 CX3CL1 CCR8 CCR7 CCR6 IL17RC CCR4 IL17RA CCR3 CCR2 XCL1 CX3CR1 CCL11 CXCR5 TNLG7C CCL1 CXCR6 BMPR2 CCL7 gdf7 CCL3 CCL19 CCL15 CCL25 CCL24 CCL22 CCL21 IL11RA GDF15 CCL20 CCL28 ACKR4 CCL27 LEPR PF4 CCL26 GHR TNFSF11 TNFRSF11B IL20RA BMP6 IL20RB GH1 TNFSF14 CCL8 GDF1 IFNGR1 GDF6 IFNGR2 IL22RA1 CD27 IFNAR2 TNFRSF12A IL17RB RELT CLCF1 TNLG8A INHA IL12RB1 TWEAK MPL TNFRSF8 IL13RA2 EDAR TNFRSF17 ACVR1 CSF3R IFNAR1 TNFRSF9 IL5RA INHBC INHBE IL13RA1 INHBA TNLG1B TNFRSF21 ACVR1C INHBB ACVR2B ACVR2A IL1RN IL3RA TGFB1 IL1R1 IL2RG TNF IL2RA BMP15 IL2RB GDF9 IL11 TNFRSF11A IL15RA IL23A TGFBR1 TGFBR2 IL1A TNFSF6 TACI TNFRSF13C FAS IFNA2 IL15 IL13 ACKR3 GHB2 IL6R TNFRSF1A GDF8 CSF2RB CSF2RA AMHR2 IL2 IL4 IL7 IL7R PRL AMH IFNG GDF5 BMPR1A IL1RL1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260410%WP4249%HOMO SAPIENS Hedgehog signaling SMURF1 EVC2 BCL2 CSNK1A1L SPOP CCND2 CSNK1G3 SMURF2 FBXL17 SPOPL CSNK1G2 BOC CSNK1G1 KIF3A PRKACG GAS1 CSNK1E DHH EVC SHH CCND1 SMO ARRB2 SUFU GPR161 PTCH1 HHIP ADRBK1 PTCH2 IHH CSNK1D KIF7 GLI3 CSNK1A1 CDON HUNGER AND SATIETY%WIKIPATHWAYS_20260410%WP5445%HOMO SAPIENS Hunger and satiety LEP NPY GCG MC4R PYY AgRP GHRL POMC VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260410%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling ADAM10 BRD4 GLUD1 PNP KDR PLCG1 VPS39 OCRL INPP4B EPHA2 PIK3CA MYH9 TBCA TEAD4 CNP ARF4 PRKD2 ANXA1 PRKD1 PPP2CA hEMMPRIN BMP2 ATF2 HBEGF CXCL8 SH3BGRL3 HDAC7 PTGS2 FOXO1 TNFRSF25 HDAC5 CTNNA1 MAP3K5 TNFRSF10C PLAUR ERN1 ACOT9 PPP3CA MDM2 CREBBP CTGF AMOT MMRN2 ATF4 ITGB3 DPM1 FGA GPX1 GJA1 SIAH2 GRB10 PRKCI MEF2C HGS SH2D2A GATA2 IQGAP1 HEL-S-15 TXN SYNJ1 RAB5A NFATC2 AP2A1 SELE XB DUSP5 NCK1 EPN1 HEL-S-78p ARF6 HEL-S-2a ALB PABPC1 AP2S1 ITCH EIF4G1 ITGB1 FLT1 ACACB ACACA TFAM NRP2 PRKG1 NFATC1 HMGB1 NUMB NCF2 MAPKAPK5 ITGAV HEL-S-133P CACNA2D1 CYBB TXNIP FRS2 BMP10 AKT1S1 SARS1 NFKBIA FXR2 PRKAA2 MOV10 NOX4 CYP2C8 CCL2 CAMKK2 DNAJB9 ADAM9 HLX PRKCB HEL164 RPL5 PRKCE PRKCA SRC PXN HEL-S-99n RELA F3 RPL10A MAPK9 PTK2B RICTOR EGR1 HEL114 RPL7 VEGFA PLA2G5 RPL18A HBD RPLP2 HEL2 NCL PTMAP7 RPS11 SDCBP PRKAA1 FOXO3A QK3 P4HA2 RPL13A SHC2 ITGB5 RPL27 RPL26 CYR61 AAG1 PDPK1 FLNB EPHB2 LDB2 ABCF2 TMSB4X CCRL2 FBXW11 HDAC9 VAV2 PFN1 TUBA1C ROCK2 ATP6V1E1 TUBB8 DECR1 TRPC1 MAPK1 CSK HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 JUN MAP2K1 TMOD1 MAP2K2 TPM3 ADRB2 S1PR1 MAPK14 EIF2A MAPK12 PLCB3 GRB2 RAF1 MYL2 SLC8A1 ELOC RPS6KA5 MLST8 RAC1 RAB11A HEL-S-87p RPS6 TPP1 HEL-S-68p HEL-S-162eP NCF1 PSMD11 CREB1 RAPGEF1 ENG MMP2 CRK MAPKAP1 MMP14 EZR PIK3R2 PIK3R1 ROCK1 SHB FOXO4 CBL CSRP2 PRKCZ RAP1A BMX CDC42 tal-1 PSMD4 FYN EIF4E TRAF3IP2 STAT1 ARHA LUC7L UBAP2L STAT3 CHAC1 PTPN11 IER5 MTOR TMEM170A SND1 ERG RPS6KB1 KATNAL2 FUT1 EWSR1 PTPN6 BIN1 ATP6V0D1 SET GIGYF2 DHX36 MYO6 MICAL2 PRRC2C BIRC5 LARP7 SRPK1 HEL-S-128m EPRS1 CALU FHOD1 HYOU1 HDAC1 DHX29 FARSB FAF1 KCNC3 GSK3B CCDC124 SRP54 EEA1 ACTG1 CCND1 CLIC1 CGNL1 ARRB2 MAPK8 SLC2A14 PAK1 SSR4 GPC1 FLII SSR3 FJX1 NAPA KANK1 CRIP2 SLC7A1 FADD APOLD1 FHL2 CLTC LMAN1 FGD5 PRKRA HEL-S-102 COPG1 CTNND1 PLOD3 TMSB10 TMOD3 SEMA6D DOK1 ARMCX1 TRPC3 RAB37 ZNF555 MAPKAPK2 DSC1 LRRC59 BCL2 FAS HTRA1 ZC3H15 CYCS CCT7 HEL-S-94n KL SDF2L1 LIMK1 HEL-S-84 AFDN TFCP2 SPIRE1 TAOK2 GRSF1 C15orf39 NRARP RND1 RAB4A CAPZB LRRFIP2 ACKR3 ADAMTS9 MMP10 ARHGEF15 SHROOM2 IGFBP7 EIF3S3 DKK1 SLC25A11 PPM1G BCL2L1 DNAJB4 FAM120A NFKB1 WASF1 SLC25A25 PDE4DIP CDC42BPB ELOA NR4A3 PTPN1 FMNL3 PTPN9 EIF3F EIF3D CTNNB1 MYO1C HEL107 DLL4 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260410%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260410%WP4220%HOMO SAPIENS Neurotransmitter disorders TPH2 PNMT TPH1 DBH DDC TH MAOA SLC18A2 SLC6A3 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260410%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK1 GCG GLP1R INS PCSK2 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260410%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia LRP6 MYC TCF3 GSK3B WIF1 JUP PML CCND1 RARA NR1C2 PYGO1 BCL9 WNT1 SALL4 CTNNB1 ZBTB16 AXIN2 LEF1 CSNK1A1 DKK1 FLT3 RUNX1T1 LRP5 APC VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260410%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPI HEL-S-302 ALPL HEL-S-1a PIGV ALDH7A1 PLPBP EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260410%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PLA2G5 PLA2G6 EHHADH PTGS2 PTGIS TBXA2R PTGS1 PTGDR2 AKR1B1 PTGIR ACOX1 PTGES PRXL2B PPARG HEL-S-298 HPGD CYP4F2 CYP4A22 NR1C2 PTGR1 PTGFR CYP4F12 PTGDR PLA2G4B CYP4A11 ACOX3 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260410%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation IGF1R FOXM1 MYC KRAS IGF1 PDGFA INS FOXO1 INSR RASSF1 AKT3 CDK4 MAPK1 PDX1 RAB43 MAPK3 FLT1 TGFBR1 CDK2 BRAF CRTC2 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260410%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder PRKAA2 GRIN3A PTEN BDNF PIK3R2 PIK3R1 EIF4EBP1 CACNA1C SYNGAP1 NRAS NF1 NTRK2 HOMER1 PRKAA1 MAPK1 TSC1 DLG4 HRAS MTOR PRKAB2 MAPK3 RPS6KB1 SHANK3 PRKAB1 RHEB GRIN1 PIK3R3 PIK3CA KRAS GSK3B UBE3A TSC2 PRKAG1 AKT3 PIK3CD PRKAG2 CAMK4 RPTOR ARC PRKAG3 GRIN2B GRIN3B NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260410%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells AOX1 UGT1A9 CYP2B6 UGT1A4 CYP2A6 APOPTOSIS%WIKIPATHWAYS_20260410%WP254%HOMO SAPIENS Apoptosis BBC3 MCL1 MYC PIK3R1 TNFRSF21 BAD NFKBIE BCL2L11 IRF1 TNFRSF10B TRAF1 BIRC5 TP63 IGF1R BIRC2 BIRC3 IRF6 IGF2 TP73 IGF1 TNF TRADD BCL2L2 CASP9 NFKBIB CASP8 CASP6 TRAF2 CASP10 CASP3 CHUK FADD DFFB NFKBIA DFFA IRF3 APAF1 TRAF3 IRF7 TNFSF6 HRK BCL2 FAS CYCS CASP4 TNFRSF25 IKBKB TNFRSF1B LTA IKBKG BAK1 CDKN2A MAP2K4 BAX JUN MAP3K1 MDM2 BCL2L1 NFKB1 TNFRSF1A TNFSF10 CASP2 MAPK10 BOK RIPK1 PMAIP1 IRF4 IRF2 BNIP3L HELLS SCAF11 RELA DIABLO CRADD PRF1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260410%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure MAPK10 HSD3B2 CASP3 STAR BAX PARP2 HEL-S-2a CYP11A1 FOLATE METABOLISM%WIKIPATHWAYS_20260410%WP176%HOMO SAPIENS Folate metabolism PLG CBS INS HEL-S-78p INSR CTH HEL-S-44 ALB SAA1 SAA2 NFKB2 MTHFD2 MTRR TNF MAT1A SHMT1 SCARB1 MPO APOB DHFR LDLR ABCA1 CCL2 HEL-S-51e FLAD1 IL6 CRP NFKB1 SERPINA3 CSF1 HBB MTR PLAT IL2 IL4 FGA GPX2 GPX1 GPX4 GPX3 GPX6 HBA2 IL1B F2 RELA IZUMO1R F7 IFNG SLC46A1 FOLR3 FOLR2 MTHFS MTHFD1 SAA4 FOLR1 SLC19A1 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260410%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 FTL FADD TICAM1 RIPK3 TNF TRADD PARP1 MAPK8 TNFRSF1A CASP8 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260410%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 ACE2 ACAT1 NRP1 SLC6A19 TMPRSS4 FURIN TLR7 CTSL MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260410%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADL EHHADH ACSL3 ACSL1 HADHB CPT2 SLC25A20 CPT1A ACADM PECR SLC22A5 FACL4 ACADVL ACSF2 ACADS FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260410%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor MAPK10 TGFB1 STAT3 ACTA2 COL1A1 MAPK9 ENPP2 LPA MAPK8 RHO CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260410%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway HSPA4 HEL-S-91n UBE2G1 CASK PSMD13 UBE2G2 SNCAIP PSMD9 PSMD6 PSMD7 FBXW7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SIAH1 HEL-S-72p PSMC6 PSMC4 PSMC1 GPR37 CASP8 UBE2J2 UBE2J1 TUBA1C TUBB PARK2 TUBB2A TUBA1A TUBA3E TUBB4B HSPA2 TUBB4A TUBB8 TUBB6 TUBB1 TUBA1B TUBA4A TUBA2 TUBA8 TUBAL3 CCNE1 UBE2L6 SNCA HEL-S-89n SIAH2 SEPT5 PSMD10 RNF19A PSMD12 STUB1 HEL-S-103 PSMD11 TUBA4B HSPA14 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260410%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PPP1CC DCAF1 MYC CUL4A LIN28B RBX1 INSR NF2 FGFR4 PRKACG KDR PRKAR1B PRKAR1A ITGB5 FGFR1 ITGB1 DDB1 FLT1 ITGB4 ITGB8 FLT3 ITGB7 ITGB6 EPHA2 FLT4 PLCB4 ITGA7 IGF1R WWTR1 FOXM1 NGFR ITGAM CCND1 ITGAV ITGA4 ITGA2 PAK1 ITGAE ITGA1 ITGAX TEAD2 LATS1 LATS2 TEAD3 CDH10 TEAD4 CDH11 CDH12 ITGA6 CDH15 CDH16 CDH17 CDH18 CDH19 KIT MET EGFR VGLL4 FGFR3 CD44 YAP1 CTNNA1 PAK6 NRAS NTRK1 NTRK2 PAK4 HRAS CDH9 PPP1R14A CDH8 CTGF AMOT HEL-S-80p CDH6 CDH4 KRAS ITGB3 CDH2 ITGA2B PDGFRA CTNNB1 AJUBA CSF1R FGFR2 CDH24 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260410%WP4823%HOMO SAPIENS Genes controlling nephrogenesis NCK2 TCF21 NCK1 ROBO2 CD36 KIRREL1 CXCL12 ETV4 FOXD1 NOTCH2 KDR LMX1B LAMB2 ITGB1 SLIT2 PAX2 CD2AP HEL-S-28 NPHS1 EMX2 NPHS2 FGF8 SHH FOXC2 WT1 SIX1 HOXD11 CTNNB1 MAFB HOXA11 LHX1 GLI3 GDNF EYA1 FGFR2 CXCR4 WNT4 TCF2 FOXC1 VEGFA RET GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260410%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways CUL4A CCNH REV1 GTF2H2C_2 FANCM FANCL FANCB MSH6 FANCE MSH2 FANCF CETN2 REV3L POLI RAD51C FAN1 FAAP24 RAD54B CENPX APEX2 GTF2H2 GTF2H3 GTF2H5 CENPS XPC PMS2 MGMT FANCC ERCC1 APEX1 ERCC2 USP1 WDR48 MPG OGG1 PNKP UNG POLE4 POLD3 POLD4 NTHL1 TDG POLD2 POLE TERF2 MUTYH MBD4 RFC3 RFC4 LIG1 RFC1 RFC2 DDB2 SMUG1 NEIL3 NEIL2 POLE2 POLE3 RAP1A CDK7 RBX1 MSH3 PCNA DDB1 HMGB1 CUL4B PRKDC PARP2 RAD51 FANCG WRN XRCC5 POLM POLL NHEJ1 PARP1 MNAT1 RPA3 CHEK1 BRCA2 RPA1 H2AX FEN1 ATR FANCD2 XPA RAD50 BRIP1 MRE11A ATM BRCA1 NBN FANCA PALB2 RAD52 POLK ERCC5 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260410%WP5088%HOMO SAPIENS Prostaglandin signaling IL1A AHR MMP9 CXCL8 CCL2 CCL3 PTGER4 PTGER2 IL6 KLRD1 IFNA1 NFKB1 CXCL1 TGFB1 IL17F IL17A PTGES CSF1 PYCARD TNF CXCL9 AREG IL1B IL12A IFNG CCR2 NLRP3 VEGFA IRF7 FOXA2 PATHWAY%WIKIPATHWAYS_20260410%WP5066%HOMO SAPIENS FOXA2 pathway ABCC3 FOXA2 ABCC2 APOB INS GSTM2 FOXO1 PPARGC1B IRS1 MLXIPL SLCO1B1 SLC27A5 FOXA1 MTTP FASN ACACA QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260410%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG FOS KEAP1 JUN PTGS2 NFKBIA IKBKB CYP2A6 NFE2L2 MAFK NFKB1 VEGFA WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260410%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis LRP6 FZD3 WNT3A PROX1 NEUROD1 CCND1 WNT7A WNT3 NEUROG2 FZD1 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260410%WP2249%HOMO SAPIENS Metastatic brain tumor CDK6 MYC PIK3R1 E2F3 CDC42 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260410%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TLR4 IRAK1 SPI1 RELA NFKB2 APOE TRAF6 INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260410%WP4558%HOMO SAPIENS Interferon mediated signaling IRF9 IFNAR1 PIK3R1 IFNA4 IFNA13 IFNE IFNA7 IFNA14 IFNA6 IFNA16 IFNA2 IFNA17 IFNW1 IFNA8 IFNA10 IF1IB1 STAT1 STAT2 IFNK IFNA21 IFNL2 IL10RB IFNL3 IFNA1 IFNL4 PIK3CA IF1AA9 PRKCA IFNGR1 IFNGR2 JAK1 IFNAR2 IFNB1 IFNG IFNLR1 TYK2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260410%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 GCKR LPL APOA2 DGAT2 APOA5 FAS LDLR SEL1L GPIHBP1 LMF1 APOA4 GCK MTTP APOC2 LIPC ACSS1 PLTP PDIA2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260410%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN1 MATN3 COL9A1 COL9A3 COL9A2 COMP PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260410%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection TUBB TLR4 TUBB2A ROCK2 TUBA1A WAS TUBA3E YWHAQ EZR ROCK1 NCK2 TUBB4B NCK1 TUBB4A TUBB8 TUBB6 TUBB1 NCL CDC42 TUBA1B TUBA4A FYN ARHA TUBA2 TUBA8 TUBAL3 ITGB1 ARPC4 ARPC5 HEL-68 KRT18 ARPC2 ARPC3 LY96 ARHGEF2 ARPC1B ACTG1 CD14 PRKCA CTNNB1 WASL PS1TP5BP1 YWHAZ CLDN1 HCLS1 TUBA1C TLR5 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260410%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin ADRB1 ANKRD23 FHL1 PRKACG MAPK1 PRKAR1A TTN GUCY1B1 MAP2K1 MDM2 MAP2K2 ADRB2 RAF1 CSRP3 ANKRD2 TCAP HEL-S-101 C22orf13 NBR1 TRIM63 TRIM55 MYPN PRKCA ANKRD1 NUP62 FHL2 CAMK2A HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260410%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260410%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling CSF3R IFNAR1 IL5RA MAPKAP1 DUSP2 SOCS3 F2R MAPK4 STAT3 MTOR PTPRC CTF1 IL3RA IL2RG MAPK8 IL2RA IL2RB PTPRT SETD7 MAPK15 AKT1S1 IFNLR1 IL15RA MAPK13 AGTR2 EGFR CNTFR MAPK7 IL9R MAPK1 F2RL2 TRIM28 MAPK3 IL10RB IL27RA IL10RA IL11RA IL21R F2RL3 IL6R CREBBP MAPK14 MAPK6 MAPK12 MAPK10 CSF2RB CSF2RA GHR DEPTOR AGTR1 PDGFRA JAK3 IL7R MAPK11 PRKCB RPTOR IL20RA IL20RB OSMR MLST8 IFNGR1 IL6ST IFNGR2 SRC JAK1 IL22RA1 IFNAR2 MAPK9 TYK2 RICTOR MPL PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260410%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 RIPK1 BIRC3 CYCS TNF TRADD CASP9 CASP8 TRAF2 CASP3 FADD BAX RIPK3 TNFRSF1A INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260410%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 JARID2 EZH2 RBBP4 SETX RBBP7 EED AEBP2 EZH1 SUZ12 MORC3 ELL BCLAF1 STK38 TRIM35 THRAP3 LUPUS THERAPIES%WIKIPATHWAYS_20260410%WP5560%HOMO SAPIENS Lupus therapies TNLG7A CD22 C4A CD40LG C2 IL25 IL6 C4B_2 IL6R IL17F IL17A IL17D CD40 CD80 IL17C C1QB IL17B C1QA IL12B IL12A C1QC IFNG MS4A1 HEL-S-62p IL23A CD19 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence EPHX2 CYP2E1 PTGES GPR32 HPGD GSTM4 CYP2C9 ALOX5 PTGS2 CYP2C8 ALOX15 ALOX15B FADS2 ELOVL5 ALOX12 ELOVL2 FPR2 LTC4S FADS1 PTGIS HEL-S-22 PTGS1 CYP3A4 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260410%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAP2K5 PIK3R2 ROCK1 PIK3R1 CDK7 ARHA MAPK4 STAT3 MTOR CTF1 CISH PIK3R3 PRKG1 PIK3CA TGFB1 IGF1R MAP3K14 PLCB2 PDPK1 GSK3B IGF1 TNF MAPK8 IKBKE CHUK WNT3A EIF2B5 HDAC9 MAP3K7IP1 LIF NPPB NFATC4 NPPA ROCK2 PLA2G2A HDAC7 MAPK7 HDAC5 CDK9 IKBKB IKBKG EDN1 MAPK1 MAP2K6 MAPK3 EGF MAP2K3 MAP2K4 PPP3CA MAP2K1 FGF2 MAP2K2 NFKB1 MAPK14 MYLK LRP5 LRP6 CALM1 RAF1 MYEF2 GATA4 DVL1 NRG1 PIK3CD PRKCB FZD1 CTNNB1 IL6ST RAC1 FZD2 FGFR2 CAMK2D MYLK3 PROLACTIN SIGNALING%WIKIPATHWAYS_20260410%WP2037%HOMO SAPIENS Prolactin signaling MYC PIK3R2 PIK3R1 CBL SOCS3 SOCS1 EIF4EBP1 FYN STAT1 STAT3 PTPN11 MTOR SOCS2 RPS6KB1 CISH PTPN6 ITGB1 PPIB PIK3CA GSK3B HEL-S-130P FLNA MAPK8 PAK1 NFKBIB CASP3 YWHAZ SIRPA HEL-S-69p NEK3 NFKBIA VAV2 ERBB2 TEC PRLR YWHAG MAPK1 FOS HRAS MAPK3 JUN MAP2K1 MAP2K2 NFKB1 MAPK14 PTPN1 GRB2 SOS1 RAF1 IRS1 RPS6KA2 PRL RAC1 SRC JAK1 PXN RELA RPS6 AGAP2 MAPK9 GAB2 VAV1 STAT5B ZAP70 CAMKK2 PATHWAY%WIKIPATHWAYS_20260410%WP4874%HOMO SAPIENS CAMKK2 pathway CHRM3 NFATC2 EPOR IFI44L KLF1 NLRP1 KDR MTOR GCK HK2 RPS6KB1 DGIC FASN ULK1 ACACA STIM1 CRTC2 SLCO3A1 MAF AQP1 C1QTNF12 TNF CXCL11 CCND1 PAK1 SLC38A5 MS4A3 HFE PARP1 IFGGE HMBS CPOX OASL TSPAN8 ERMAP GALNT9 MAMDC2 MID1 CAMK1 ERAF SPINT1 DKFZp762B153 EP300 SFI1 SQSTM1 S100A8 KEAP1 ATP10D TSPAN33 RHD ENHO CCL5 ABCA1 CYB5R3 MAP1LC3A HMOX1 SLC25A21 WFS1 MX2 SPIRE1 IL15 CAMKK2 LR8 TRPV4 TSC1 MAPK1 RHAG FAM20C FIS1 SIRT1 ARHGEF7 SLC2A4 MAPK3 CCNE1 NFE2L2 ASNS CALM1 WDR35 RAF1 SMC1A TBXT CAMK4 RPTOR PFKFB2 RAC1 VCAM1 SELL HIF1A RELA RPS6 ATP1B2 CREB1 PCK2 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260410%WP247%HOMO SAPIENS Small ligand GPCRs S1PR2 CNR1 MTNR1A S1PR3 PTGFR GPR50 PTGER4 S1PR4 PTGDR PTGER1 PTGER2 PTGER3 CNR2 MTNR1B TBXA2R LPAR1 S1PR1 PTGIR MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260410%WP5236%HOMO SAPIENS Markers of kidney cell lineage EGLN2 NR2A1 PECAM1 TCF21 NOTCH2 KDR SMAD1 DCN PAX2 BMP7 NPHS1 NPHS2 DKFZp781O1323 HNF1A GDNF BMP4 KIT NTN1 FOXD1 TLX1 CITED1 RSPO3 DACT1 OSR1 AXIN2 KCTD1 TSHZ3 TBX18 FAT4 VSX2 SFRP1 EMX2 ACTA2 NT5E FGF7 FGF8 EPO PBX1 tmp_locus_29 WT1 REN SIX1 SALL1 RSPO1 LHX1 SIX2 ALDH1A2 NOTCH1 EYA1 WNT4 TCF2 TNC EGLN1 EGLN3 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260410%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 ERBB2 AREG HEL113 MYC EGF TIMP1 CCND1 FOSL1 PGR REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260410%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds TNKS DKK3 GSK3B DVL2 WNT1 FZD1 CTNNB1 LEF1 CSNK1A1 AXIN1 FZD7 SFRP4 MBOAT1 FZD8 APC TCF4 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP304%HOMO SAPIENS Kit receptor signaling DOK1 CRK TEC KIT PIK3R2 PIK3R1 EP300 CBL SOCS1 BAD RPS6KA3 FYN KITLG INPP5D STAT1 MAPK1 STAT3 FOXO3A PTPN11 HRAS PLCG1 MAPK3 RPS6KB1 PTPN6 MAP2K1 MAP2K2 SOCS6 MATK MAPK14 SH2B2 LYN GRB2 RPS6KA1 SOS1 RAF1 GRB7 MAPK8 CRKL PRKCB GRB10 PRKCA SRC RPS6 GAB2 BTK VAV1 STAT5B TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260410%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway H4C9 TAF13 TAF8 MED27 MED23 TBP IL1 SIGNALING%WIKIPATHWAYS_20260410%WP195%HOMO SAPIENS IL1 signaling IL1A MYD88 PIK3R2 MAPKAPK2 ATF2 PIK3R1 SQSTM1 PRKCZ IKBKB IKBKG MAPK1 PTPN11 PLCG1 MAP2K6 MAPK3 MAP3K2 REL MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 NFKB1 ECSIT MAPK14 HSPB2-C11orf52 IRAK2 IL1R1 MAP3K14 TAB3 MAPK8 NFKBIB IRAK1 CHUK IL1B RELA IRAK3 HEL-S-71 MAPK9 MAP3K7 IRAK4 PELI1 NFKBIA MAP3K7IP1 TRAF6 UBE2V1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260410%WP528%HOMO SAPIENS Acetylcholine synthesis ChAT ACHE CHKA PEMT PDHA1 PDHA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260410%WP3925%HOMO SAPIENS Amino acid metabolism G6PC2 RARS1 CBS PDHX GLUD1 CTH P4HA2 TPH1 FH DBH MDH2 HEL-S-61p SDHA ACLY CS PC OGDH TDO2 SUCLG1 EPRS1 MARS2 ACO2 DLD GOT2 PNMT HMGCL FARSB HAL HEL-S-32 GPT2 HEL-S-30 PIG59 ADH1C HEL-S-133P GCLM ADH7 HEL-S-4 ADH5 SRM DDC TH CAD MAOA ARG2 HDC EHHADH BCAT1 HEL-S-26 SMS ACSS1 ALDH7A1 ASNS PDK4 ALDH18A1 LARS2 PPM1L IARS HEL-S-53e PCK1 HEL-S-64p GLS ARG1 ACADM HEL-75 ASS1 OTC PDHA1 FTCD MCCC1 TPO TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260410%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome AHR TDO2 AADAT HAAO GOT2 AFMID KYAT3 KYAT1 IFNA6 IDO2 TNF KYNU KMO IL1B IFNB1 IL6 IFNG DDC IDO1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260410%WP100%HOMO SAPIENS Glutathione metabolism GSTM1 GSTM2 GPX2 GCLC GPX1 GPX4 GCLM HEL-S-64p GPX3 GSTT2 HEL-S-26 OPLAH HEL-75 GSTA5 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260410%WP2363%HOMO SAPIENS Gastric cancer network 2 OTUD5 UBE2C SNURF EGFR MYC COL9A1 COL9A3 DGIC CEBPZ CHTF18 TOP2A S100A6 DSCC1 CHTF8 BRIX1 ATAD2 LMNB2 CACYBP FAM91A1 RNF144B UBE2T AHCTF1 CD48 RAD17 CTNNB1 RFC3 RFC4 MTDH LBR TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260410%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 LATS1 TEAD2 LATS2 HDAC1 SKI MERTK TEAD3 TEAD4 SKIL SIN3A NF1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260410%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome RAB5A NFATC2 PLN SH2B1 RABEP2 INSR KDR RAB4A ATP2A1 SLN TRAF1 CD82 GRB2 IL4 NFATC2IP TUFM TRAF2 ATXN2L SPNS1 CD81 LAT SDCCAG8 PRMT1 CR2 IFITM1 HEL-S-62p MPL VAV2 CD19 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NEU2 B3GNT5 FUCA1 FUT5 NAGA FUT2 SIAT4C FUT1 B4GALT4 B4GALT1 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260410%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions LPL YWHAQ FOXO4 MOB1A YAP1 RAP1A FOXO1 ARHA FOXO3A MAPK14 STK38L WWTR1 FOXP3 PRDM1 RAC1 TEAD2 LATS1 LATS2 TEAD3 FOXO6 CCR7 TEAD4 FYB1 KNSTRN RAB13 FERMT3 CD19 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260410%WP2596%HOMO SAPIENS Gastric acid production PGA5 MUC6 GAS CCK CBLIF SCT PGA3 VIP PGC IL6 SIGNALING%WIKIPATHWAYS_20260410%WP364%HOMO SAPIENS IL6 signaling PIK3R2 PIK3R1 SOCS3 BAD NCOA1 STAT1 MAPK1 STAT3 PTPN11 IRF1 MAPK3 RPS6KB1 IL6 MAP2K4 MAP2K1 CRP BCL2L1 MAP2K2 IL6R CREBBP GRB2 HDAC1 PRDM1 NLK SOS1 GSK3B TIMP1 NR2F6 JUNB IL6ST RAC1 JAK1 MAP3K7 TYK2 VAV1 VIP CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260410%WP4504%HOMO SAPIENS Cysteine and methionine catabolism SUOX SQOR CBS MTR MAT1A pcap HEL-S-61p GCLC CTH CDO1 HEL-S-64p ETHE1 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260410%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260410%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects RPS6KA6 TTF2 TTF1 NHSL1 DUOXA2 SECISBP2L DEHAL1 BAD SLC26A4 TRH ADRB3 TG MTOR DUOX2 SIRT6 RPS6KB1 MC4R FGFR1 AgRP ITPR2 AQP7 PIK3CA SLCO1C1 PRDM16 TSHB PPARG SLC16A10 GSK3B SLC16A2 PPARGC1A SHH ITGAV ADCY3 CASP9 AKT3 ZNF516 ACTL6B KDM3B UCP1 TSHR FRS2 THRA AKT1S1 NPPB MAPKAPK3 SLC5A5 NPY ATF2 ADCY8 FGF21 FOXO1 POMC PLIN1 MGLL PNPLA2 TSC1 MAPK1 HRAS MAFA RXRA RHEB MAP2K1 TBC1D4 MDM2 MAPK14 GRB2 SOS1 RAF1 ITGB3 TSC2 KDM1A RPTOR PFKFB2 CTNNB1 MLST8 DIO1 SRC CREB3 NOTCH1 RPS6 PAX8 WNT4 NR1A2 TPO COMPLEMENT SYSTEM%WIKIPATHWAYS_20260410%WP2806%HOMO SAPIENS Complement system PLG TXN C1QBP RPS19 SERPING1 SELE MASP1 CD46 CLEC4M ICAM2 VTN HEL-S-78p C4A FCGR3A C1S VSIG4 CFH CD93 ALB HEL-S-92n CFI FCER2 FKBP2 CFP CD59 CFHR2 CFHR4 PTX3 SFTPA1 F10 PROS1 DCN ADM CPN1 ELANE LAMC1 FPR1 GNAI3 ARRB2 ITGA2 SELP CR2 CD19 LAMA5 WAS F13A1 CFD C2 PLAUR CD55 THBS1 LAMB1 CRP GNA15 IBSP CD40 ITGB3 ITGA2B SPP1 FGA PRNP PRKCA C5AR2 SELL FCN1 FCN2 HEL-S-99n F11 SELPLG C6 C4BPA C7 CSNK1A1 SFTPA2 HEL-S-62p C9 KLKB1 C5AR1 C3AR1 MBL2 MASP2 C8A CR1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260410%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR DHFR AHCYL2 MAT1A TCN2 HEL-S-51e FOLH1 MTHFD1L SHMT1 MTFMT GLRX TYMS HEL-S-70p AMT MTHFS HEL-S-61p FTCD MTHFD2 CHDH MTHFD1 DNMT3B PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260410%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins PRKAA2 LARP1 ATG9A DKFZp762B153 ATG3 SQSTM1 APOB ATG12 EIF4B ATG16L1 MTOR VPS39 RPS6KB1 RHEB VPS11 VPS16 VPS18 VPS33A ULK1 CALCOCO2 VAMP8 VPS41 OPTN RAB7A DEPTOR RB1CC1 LAMP2 PPP1R9A LAMTOR1 HEL-S-30 TMEM59 NBR1 RPTOR MLST8 RPS6 AKT1S1 ATG2B ATG5 GABARAPL2 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260410%WP5559%HOMO SAPIENS Lupus pathogenesis TLR4 IL17A TNFRSF13C TNLG7A CD40 BCR CD80 ICOSLG IFNA2 CD40LG ICOS IL6 PDCD1 TLR9 TLR7 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260410%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PTEN MYC PIK3R2 PIK3R1 BAD EIF4EBP1 EIF4E PLCG2 KDR STAT3 FOXO3A BCL2L11 MTOR PLCG1 RPS6KB1 SHC4 SHC2 SHC3 PIK3R3 PIK3CA PDGFD PDGFC IGF1R PDPK1 GSK3B IGF1 PDGFA CCND1 AKT3 HGF TGFA ERBB2 MET EGFR FGFR3 BCL2 ERBB3 ARAF NRAS NF1 RRAS NRG2 MAPK1 HRAS MAPK3 EGF IL6 BAX MAP2K1 RPS6KB2 BCL2L1 FGF2 MAP2K2 RRAS2 BRAF IL6R GRB2 KRAS SOS1 RAF1 SOS2 PDGFRA NRG1 PIK3CD PRKCB PRKCA AXL SRC JAK1 RPS6 FGFR2 VEGFA VITAMIN D METABOLISM%WIKIPATHWAYS_20260410%WP1531%HOMO SAPIENS Vitamin D metabolism CYP24A1 CYP2R1 PTH RXRB RXRA DHCR7 CYP27A1 CYP27B1 NR1i1 GC TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260410%WP465%HOMO SAPIENS Tryptophan metabolism AHR ECHS1 AANAT AOX1 STAT1 CYP1A1 IL4I1 TPH2 TPH1 ASMT IDO1 AOC1 ALDH8A1 TDO2 HAAO AADAT AFMID GOT2 DLD ACAT1 KYAT3 KYAT1 IDO2 KYNU INMT ALDH2 KMO GCDH DDC MAOA KALLMANN SYNDROME%WIKIPATHWAYS_20260410%WP5074%HOMO SAPIENS Kallmann syndrome OTX2 SOX10 SEMA3E TMEM98 GRB2 FGF8 NEUROG1 LHB PLXND1 OLIG2 MAPK1 PTPN11 FRS2 GNRH1 PROK2 FGFR1 MYRF ASCL1 MAP2K2 ANOS1 PIK3CA BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260410%WP3927%HOMO SAPIENS BMP signaling in eyelid development EGFR DKFZp781O1323 SHH FOXC2 INHBB SMAD4 MAPK3 NOTCH1 SMAD1 MAPK9 FGFR2 FGF10 JUN TGFA FOXC1 DKK2 MAP3K1 PITX2 SFRP1 BMP4 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260410%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 IVD ACSF3 DBT DLD ECHS1 ACAT1 MLYCD HSD17B10 ACADSB BCAT1 BCAT2 MCCC2 PCCA MCCC1 PCCB IL19 SIGNALING%WIKIPATHWAYS_20260410%WP5422%HOMO SAPIENS IL19 signaling TGFB1 CCL11 ACTA2 MUC5AC TNF IL4 SOCS1 MAPK8 SOCS5 STAT1 IL20RA IL19 IL20RB STAT3 MAPK1 RAC1 COL1A1 JAK1 MAPK3 CCNB1 CXCR4 NFKB1 MAPK14 TNFRSF1A KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260410%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 SERPING1 KLKB1 CPN1 BDKRB2 BDKRB1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260410%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV SHANK1 RPH3A CAMK2G TJP1 YWHAG SYNGAP1 DLGAP1 HOMER1 MAPK1 MAPK3 GRIN1 CYFIP1 FMR1 DLG2 RYR2 NLGN1 NRXN1 NRXN3 ARC NRXN2 STX1A CAMK2D CAMK2A GRIN2B NLGN3 NLGN2 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260410%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH3 ALKBH2 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260410%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ZMPSTE24 ICMT COCAINE METABOLISM%WIKIPATHWAYS_20260410%WP2826%HOMO SAPIENS Cocaine metabolism CES2 CES1 BCHE CYP3A4 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260410%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling STEAP3 ACE2 CTSL IL18RAP IFIT1 APOL1 ULK1 HEL-S-72p APOH COQ8B RTN4 SELP TP53I3 IFITM1 IL10 CXCL2 LARP1 MX1 CXCL8 PTGS2 IL9 INTS4 IKBKG IF2B1 FOS CD3G CD3E IL6 IL-21 RHEB GGH FGF2 TNFSF10 IL17A HBB DEPTOR TOMM70 IL18 FGA IL1B TPO NLRP3 C1QBP IFI44L HEL-S-78p CXCL12 CXCL6 C1S CFH IL5 CASP5 ALB C1R CFI SAA1 NLRP1 CFP SAA2 ITCH SMAD1 VPS11 VPS16 CEBPB VPS18 IL33 VPS33A VPS41 CXCL1 DDIT4 CXCL5 DKFZp781O1323 HEL-S-130P IFITM3 CCNB2 HEL117 GTSE1 VPS36 WDR74 IFI27 IL1R2 CD226 TBK1 HEL103 TRAF2 BST2 IRAK1 HRG CTSZ SERPINA10 IFNB1 SDF2 IL16 HMFT1766 AKT1S1 IFI6 OS9 SRP19 CARD11 HEL-S-81p IRF3 HP TRAF3 PMPCB TRAF6 CLCC1 NFATC3 GTF2F2 UGCGL2 MYD88 PITRM1 G3BP2 NPTX1 DKFZp762B153 MOV10 MDN1 FAM83A TRO TRIM59 ITIH4 TBKBP1 ITIH3 CCL5 CCL4 ATE1 CCL2 ATP13A3 FAM98A NTRK1 APOC1 CRP APOA2 TLE3 ADAM9 LBP CD14 JUNB HIF1A EGR1 HBD IFIH1 MAVS CDC2 RIGI CXCL13 CXCL16 IL8RB LGALS3BP TF CCR5 SIGMAR1 TRPM2 CXCR1 CXCL9 CXCL3 RRM2 CCR6 CCL11 AHR CD163 CCL1 EIF4A2 RRAS CCL3 APOD CCL15 CCL22 JUN CCL21 CCL20 CCL27 PF4 CCL26 CAMK4 RPTOR CCL8 GP1BA CD8A MLST8 RAC1 JAK1 CCNB1 RPS6 PIAS1 ZAP70 LCK GABARAPL2 IRF9 EIF4EBP1 OAS2 FYN EIF4E STAT1 MTOR NFKB2 PTPN6 CPN1 BIRC5 NRF NEK9 CD8B1 PRG3 CD2 MMP25 IGLL1 TNF SRP54 PARP2 ACTG1 CASP9 MAPK8 CASP8 PS1TP5BP1 CASP3 PRKCQ IL12A TGFBR2 IL1A IL13 HLA-DRB5 HLA-DRA HLA-DRB1 MIB1 IL4 IL7 IFNG C8A ROTENONE METABOLISM%WIKIPATHWAYS_20260410%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260410%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260410%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly HIRA H4C9 HIST1H4L CHAF1B SMIM40 RBBP4 CHAF1A H2BC12 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome ADAM10 MYC MCRS1 TFRC SLC40A1 RNF168 FBXW7 NF2 PIK3R3 TGFB1 TF SLC51A SLC51B DYNLRB2 PIGX HEL-S-71 PIGM HFE CEP19 DYNLT3 DYNC2I2 DYNLT1 UBXN7 SMCO1 NCBP1 NRROS NCBP2 FNDC8 MFI2 SIRT1 MYCBP2 FBXO45 ZDHHC19 BRINP1 TM4SF19 JUN CEP350 MAD2L1BP WDR53 ZNF76 RABL2B RNF8 DYNC2H1 H2BC21 HAMP DYNLL2 PXN HIF1A DNCL1 DYNLT2B STAT5B DYNC2LI1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP558%HOMO SAPIENS Complement and coagulation cascades PLG SERPING1 MASP1 CD46 F2R HEL-S-78p C1S CFH C1R CFI KNG1 F9 PROC F10 PROS1 F13B C4B_2 VWF C1QB C1QA THBD C1QC CLTC CR2 LMAN1 CFD C2 PLAUR CD55 SERPINA1 CPB2 SERPINC1 TFPI PLAT BDKRB1 SERPINF2 F2 F3 F5 F7 C6 F8 C7 HEL-S-62p CLU C9 KLKB1 C8G C5AR1 C3AR1 MASP2 CR1 SERPIND1 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260410%WP4814%HOMO SAPIENS Somatic sex determination DMRT1 DHH GATA4 FOXL2 NR5A1 FGF9 WT1 CTNNB1 SOX8 SOX9 SRY RSPO1 AMH WNT4 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260410%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum GPS1 H4C9 CUL4A MNAT1 CCNH HIST1H4L CDK7 GTF2H2C_2 RPA3 RPA1 RBX1 PCNA CETN2 GTF2H2 GTF2H3 DDB1 GTF2H5 XPA SLX4 CUL4B SLX4IP CHD1L BRCA1 POLE4 POLD3 POLD4 HMGN1 H2AC6 RAD18 POLD2 XPC POLE POLK RFC3 RFC4 LIG1 ERCC1 RFC1 ERCC2 RFC2 DDB2 H3F3B PARP1 XAB2 POLE2 UVSSA POLE3 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260410%WP4298%HOMO SAPIENS Acute viral myocarditis MMP9 PIK3R1 SOCS1 FYN PABPC1 STAT1 CD40LG STAT3 NFKB2 EIF4G1 SGCA HEL-S-28 TGFB1 AAG1 NOD2 HLA-DMA PYCARD CCR5 GSK3B TNF CCND1 CASP9 CASP8 CASP6 PS1TP5BP1 CASP3 IL12B IL12A TICAM1 IL10 CCR3 DFFB DFFA PARP1 TLR5 TLR4 AIF1 BCL2 CYCS SGCD SGCB RAC3 SGCG EDN1 MAPK1 ABL2 MICA CD55 MAPK3 IL6 BAX DMD BCL2L1 CASP2 CAAP1 CD80 CXADR SOS1 CHRAC1 BNIP2 TLR3 IL2 MYH6 DAG1 SRC JAK1 IFNG CXCR4 CREB1 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NPC1 GLB1 LIPA NEU3 GM2A PSAP NEU4 NEU1 GLA SCARB2 NEU2 NPC2 HEXB HEXA KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260410%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB SUCLG2 SUCLG1 FH GPT PDHX MPC1 DHTKD1 HEL-S-133P SUCLA2 PCK2 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260410%WP186%HOMO SAPIENS Homologous recombination RAD50 MRE11A ATM RAD54B NBN POLD3 POLD4 BRCA2 POLD2 RPA1 RAD51 RAD52 NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP268%HOMO SAPIENS Notch signaling PSEN2 RBPJ HES5 DTX1 APH1B NCOR2 NOTCH2 KCNJ5 NOTCH3 DTX3L MAML3 DTX4 MAML1 CREBBP CTBP2 CTBP1 NUMB HDAC2 HDAC1 JAG2 DVL1 DVL2 DVL3 RBPJL DTX2 DTX3 KAT2B KAT2A PSEN1 MFNG NOTCH1 ADAM17 DLL3 DLL4 LFNG HES1 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260410%WP619%HOMO SAPIENS Type II interferon signaling IRF9 ISG15 H4C9 MHC2TA SOCS3 IFNA2 SOCS1 EIF2AK2 OAS1 IRF8 STAT1 NOS2 STAT2 PTPN11 IRF1 HLA-B SPI1 IRF4 CXCL9 CYBB IFNGR1 IRF2 GBP1 IFNGR2 JAK1 IL1B IFNB1 IFNG IFI6 IFIT2 TAP1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases RBPJ PIK3C2G PIK3C2A PIK3C2B PIK3R3 PIK3R5 PIK3CA SMO PTCH1 IHH GLI3 PRKD1 FGF7B MAPK13 BMP4 BMP2 FGF7A FGF18 FGFR3 BMPR2 MAPK1 MAPK3 FGF5C RUNX2 FGF2 MAPK14 LRP5 MAPK12 LRP6 MAPK10 FGF7 FGF8 JAG2 FZD4 PIK3CD HEY2 HES6 PRKCI WNT9B WNT9A NOTCH1 WNT8A WNT8B PIK3R4 PIK3R2 PIK3R1 PRKCZ NOTCH2 NOTCH3 STAT1 FGFR4 MAPK4 SMAD1 FGF10 FGFR1 SMAD9 DKFZp781O1323 PPARG MYOD1 PRKDC MAPK8 PRKCQ SMAD4 WNT3A WNT2B FZD10 MAPK7 WNT5B WNT16 MAPK6 PRKCH WNT1 MAPK11 FGF9 PRKCB WNT3 PRKCE FZD1 PRKCA CTNNB1 WNT10B SOX9 WNT10A FZD3 HES3 HES2 FZD2 FZD5 FGFR2 MAPK9 WNT4 WNT7B FZD7 FZD9 DLL3 DLL4 WNT7A FZD8 BMPR1A MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma CRK PIK3R2 PIK3R1 CBL RPL11 RAP1A BAD CDC42 KDR STAT3 PTPN11 PLCG1 ALK PIK3R3 PIK3CA AKT3 MAPK8 PAK1 CDKN1A HGF MET STRN PAK6 ARAF NRAS MAPK1 PAK4 HRAS MAPK3 JUN MAP2K1 MAP2K2 BRAF PRCC ELOA GRB2 KRAS SOS1 RAF1 SOS2 JAK3 PIK3CD CRKL RAC1 SRC INSL3 C8orf34 VEGFA RAPGEF1 IL17 SIGNALING%WIKIPATHWAYS_20260410%WP2112%HOMO SAPIENS IL17 signaling IKBKB IKBKG TRAF3IP2 SP1 MAPK1 STAT3 IL25 MAPK3 CEBPB NFKB1 CEBPD PIK3CA IL17F IL17A MAP3K14 IL17D IL17C IL17B GSK3B NFKBIB JAK1 RELA MAP3K7 IL17RB IL17RC IL17RA TRAF3 TRAF6 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260410%WP2005%HOMO SAPIENS miR targeted genes in muscle cell CDK6 EZH2 ABCG2 IGF2BP1 SPARC ARID4B PHLDB2 TXN2 CHORDC1 CDK5RAP3 VPS39 ATP6V0E1 TNFRSF10B IFRD1 HEL-S-66 PISD MTHFD2 RAB34 PPIF PPIB ANAPC1 MYO1E TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 RDH10 SNX6 CD164 BRPF3 HMGA1 TBCA IGF2R CDKN1A CLDN1 SFXN1 SLC25A1 ARF4 SNAP23 TNFAIP2 ATP2A2 SLC7A11 MRC2 HYAL3 KIT SPTLC1 YWHAQ TMEM43 TMED3 CCNG1 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC HMOX1 SCYL1 SLC7A6 CDCP1 RFT1 FRG1 TYMS RHEB THBS1 PPP3CA HEL-S-47e EHMT1 PTPA DNAJB1 FGF2 POLR2C USP1 SHOC2 CDIPT SRSF10 CA12 AP3D1 ARHG ARCN1 WDR11 CSF1 POLE4 FMNL2 TDG POLD2 GJA1 PRKCI NOTCH1 ACVR1B BACE1 MCL1 C1QBP PXDN CXCL12 NF2 CAND1 GFPT1 NEDD4 CEBPB ITGB4 LAMC2 CUL4B CPNE8 LAMC1 VEZT TMEM41B PWP1 MTRR RAVER2 CIAO2A SEC62 HEL-S-30 ITGA2 MBNL1 SLC38A1 HEL-S-303 TRAM1 CBFB CACNA2D1 FNDC3B GRIA2 CSNK1D FNDC3A CARHSP1 WDR82 HACD3 SLC38A5 UBE2J1 COMMD9 GRPEL2 ATP6V1C1 RAB27B UHRF1 MOV10 POLA2 NCEH1 MAPK7 STRN ANP32B MYLIP RNP24 GFM1 MAGT1 PANX1 COIL COL1A1 SERP1 DHX15 COL3A1 GNPNAT1 TMED7 MRPS24 ELMOD2 TMT1A PSAT1 AP3B1 CSDE1 SSNA1 NAPG NT5E PGRMC1 PPP1R7 MPZL1 SPRYD4 CDKN1B TTC9C SPCS3 TPPP3 GPAM NFIA AXL SNX15 PKN2 LAMTOR5 TMEM87A SLC25A13 VSNL1 FAR1 FSTL1 LTN1 CAMTA1 ABHD10 DSG2 POGLUT3 KPNA3 BACH1 RARS1 ATG9A STX7 UBE4A CDKAL1 RAB30 SYPL1 ADAR GPD2 NCL PLK1 PTMAP7 GEMIN7 SRSF9 RAI14 SDCBP SLC4A10 GNL3L COL1A2 P4HA2 CHMP2A SRPRB DKFZp761E1322 PICALM DOCK5 CALCOCO2 DOCK7 CYR61 SYNE2 SYNE1 SNAP29 HSDL1 RCN2 RBMS1 SEC23A LUZP1 NUFIP2 NXN HSD17B12 GNA13 TP53INP1 ASH2L SH3BP4 ZNF622 PDLIM7 SLC25A24 SLC12A2 GALNT7 NHERF2 TM6SF1 SLC4A7 CPOX RQCD1 SLC25A32 LPL BET1 EGFR CYP1B1 GALNT1 NRP1 ERBB3 HEL-S-273 HEL-S-108 TPM3 MAPK14 MAPK12 TPM1 KRAS LAMTOR3 GSTM4 IRS1 CYP51A1 EIF4E NOTCH2 ARID1A ERG PDE3A RB1 E2F3 LMNB2 CCND1 TGFBR2 ERBB2 MET AMIGO2 BCL2 PTPRF FADS2 CTNNB1 HES1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260410%WP4147%HOMO SAPIENS PTF1A related regulatory pathway CTNNB1 KAT2B RBPJ PDX1 NKX6-1 NOTCH1 PROX1 FGF10 PTF1A RBPJL HES1 CHOLESTASIS%WIKIPATHWAYS_20260410%WP5238%HOMO SAPIENS Cholestasis ABCC3 SCARB1 ABCC2 EPHX1 NR1I3 ATP8B1 ABCB4 SLCO1A2 LDLR ABCB11 HMGCR RXRA NR1H4 SLC22A1 ABCG8 ABCG5 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260410%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex PWWP2A H3C15 RRN3 TAF1D EP400 MTA2 H4C9 MBD2 HIST1H4L GATAD2B GATAD2A CDK2AP1 HIST1H2AB SRCAP ASF1B H2BC15 HDAC2 HDAC1 UBTF MBD3 TAF12 EP300 RBBP4 H2AX POLR1A POLR1C POLR1D TLK2 MAPK3 CREBBP ASF1A H2AC19 H2AC14 H2BC26 SIRT7 H2BC12L H2BC21 H2BC9 H2BC8 H2AC6 H2BC3 H2BC1 TBP H2BC17 HAT1 H2BC12 H2BC13 KAT2B KAT2A H2BC14 CHD4 H2AC20 H2BC11 HIST1H2BE TAF1B H2AZ1 H2AZ2 H3C8 H3F3B H2AB1 PWWP2B CHD3 H2AJ CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260410%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260410%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MCL1 C1QBP USP9X PLEK PYCR2 UBXN1 CLPB FLJ10842 TXN2 MICOS13 OPA3 STAT2 GDAP1L1 PMPCA UBXN6 PAM16 OXA1L PPA2 TMEM126A YME1L1 MICU1 SPG7 MFF TIMM50 MSTO1 MARCHF5 DNAJC19 ATAD3A TIMM8A GFER COQ5 COQ3 NPLOC4 SFXN4 RTN4IP1 TXNRD2 HSPD1 PMPCB PARK2 PITRM1 MIPEP SACS OPA1 PINK1 MFN1 MFN2 TIMMDC1 CLPP LONP1 AIFM1 TRAK1 UFD1L XPNPEP3 VCP HTRA2 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260410%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA RPE HEL-S-304 HEL107 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies EGFR F2RL1 IFNG IL-21 DHODH IL2 TNF ITGA4 ITGB7 IL15 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260410%WP4155%HOMO SAPIENS Endometrial cancer PTEN MYC PIK3R2 PIK3R1 BAD FOXO3A FGFR1 PIK3R3 PIK3CA HEL-S-28 PDPK1 GSK3B CCND1 CASP9 AKT3 CDKN1A AXIN1 APC ERBB2 EGFR GADD45B GADD45A FGFR3 GADD45G CTNNA1 ARAF CTNNA3 BAK1 APC2 NRAS CTNNA2 MAPK1 FOS HRAS MAPK3 AXIN2 EGF BAX MAP2K1 FGF2 MAP2K2 BRAF GRB2 KRAS SOS1 RAF1 SOS2 PIK3CD POLK CTNNB1 TCF7L2 TCF7L1 DDB2 LEF1 FGFR2 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260410%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling MAP3K14 CXCL8 TNF TRADD CCL5 IKBKB MAPK8 IKBKG MAPK1 IRAK1 CHUK IFNB1 RELA NFKB2 MAP3K7 PDLIM7 CCL20 NFKBIA TRAF1 NFKB1 TRAF6 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260410%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition RAD21 ESPL1 MAD1L1 BUB1B CENPE SMC3 CDC20 SMC1A MAD2L1 PTTG1 STAG1 APC VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2877%HOMO SAPIENS Vitamin D receptor pathway SULT1C2 ATP2B1 MYC CDKAL1 CDKN2B IRF8 CDKN2C LGALS9 CTLA4 TRPV6 DND1 CDKN2D G0S2 CCNC S100A6 MED9 LPGAT1 GXYLT2 KRT71 IGFBP1 SLC34A2 S100A2 TNLG2B LCE1F LCE1D LCE2B CDC34 NINJ1 COL13A1 HNF1A CRACR2A CRACR2B BCL6 BTLA KRTAP4-1 CDKN1A SLC37A2 KRTAP12-2 CYP2S1 PNOC CLPTM1L ALPG PTHLH ZNF257 SPRR1B ORM1 ORM2 CYP3A4 DUSP10 DACT2 KRTAP5-1 CA9 ABCD1 KRTAP5-4 S100A8 KRT34 CEACAM1 KRT38 SATB1 FOXO1 HEL57 SEMA3B ASAP2 CST6 CST1 MX2 EPHB4 CYP1A1 CLMN CREG2 LRRC25 S100G IL25 KRTAP10-2 CDKN2A KRTAP10-4 SLC2A4 KRTAP10-7 KRTAP10-9 KRT13 SULT2A1 CCNE1 CDX2 MYO9B DEFB132 CDK2 KRT16 CD9 ADRB2 LRP5 TPM1 MXD1 BGLAP PTH TNFSF11 ADAMTS5 TNFRSF11B TIMP3 SLC8A1 BMP6 EFNA5 FGF23 NFATC2 CASP14 SOSTDC1 CBS ALOX5 IGFBP5 CAMP CASP5 DEFB4B CYP27B1 NR1i1 KNG1 CYP24A1 S100A4 HSD17B2 CEBPA CLDN2 KLK6 TGFB1 KRTAP8-1 ABCB1 TRPV5 PRDM1 CD200 ITGAM CCND1 ID4 TNFAIP3 TREM1 THBD CLEC16A DNER PRKCQ IL12A GADD45A CYP2C9 ID1 KL CYP2B6 HILPDA PTGER4 HLA-DQA2 HLA-DQA1 RXRA CYP7A1 HLA-DRB1 STEAP4 SFRP1 ADRA1B TRAK1 CD40 KLF4 S100A9 CDKN1B IRF4 SPP1 CD14 JUNB NR1C2 SALL4 BDKRB1 ALPI ADGRE5 STS HIF1A COLEC11 IL1RL1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260410%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS PSAT1 PHGDH SLC7A11 PSPH PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260410%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence ALOX5 PTGS2 IGFBP5 ALOX15B NRAS ALOX5AP PTGER4 PTGER1 HRAS PTGER2 SIRT1 PTGER3 PTGIS PTGS1 KRAS PTGES PRXL2B RB1 ALOX15 ADCY3 ALOX12 GNAI1 MAPK11 LTC4S CDKN1A GNAS PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260410%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MYEF2 GATA4 MAPK11 MAPK8 EDN1 PRKCB PRKCE ARHA STAT3 MAPK1 FOS IL6ST RAC1 CTF1 MAP2K3 CAMK2D JUN PPP3CA MAPK14 NFATC4 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260410%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP2K5 NFATC2 CDK7 MTOR PRKG1 TGFB1 MAP3K14 PDPK1 GSK3B IGF1 TNF MAPK8 IKBKE CHUK MAP3K7 MAP4K1 TGFBR1 HDAC9 PRKD1 NPPA PLA2G2A HDAC7 MAPK7 HDAC5 CDK9 IKBKB IKBKG MAPK1 MAP2K6 MAPK3 EGF MAP2K3 MAP2K4 PPP3CA MAP2K1 MAP3K1 GUCA1A FGF2 MAP2K2 NFKB1 TNFRSF1A MAPK14 CALM1 RAF1 NRG1 PRKCA RAC1 FGFR2 CAMK2D HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260410%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TFAP2A TP63 IRF6 ARHGEF2 ARHGAP29 ARHA GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260410%WP4157%HOMO SAPIENS GABA metabolism aka GHB GLS GLS2 PON3 HEL-S-166mP ABAT ADHFE1 GAD2 GAD1 ALDH5A1 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260410%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NQO1 TGFB1 BMP2 COL2A1 FGF7 NRF1 CDC37 EXOC6 SUV39H1 PKD1 SIRT1 IGFBP7 NFE2L2 HEL-S-7 DDR1 ECSIT LOXL4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260410%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling ATF2 BCL2 RPS6KA3 EIF4E MAP3K10 MAPK1 FOS MAP2K6 MAPK3 MAP3K11 MAP2K3 MAP2K4 JUN DDIT3 MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK12 IFITM2 MAPK10 RPS6KA1 RAF1 IFITM3 JUNB MAPK8 MAPK11 RPS6KA2 IFI27 BST2 MAPK9 IFITM1 MAPK13 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAA2 FMO5 KIRREL1 TJP1 AFDN PRKAA1 PRKAB2 PRKAB1 F11R ACP6 AMELX CHD1L NBPF12 PYGO2 TJP3 PRKAG1 PYGO1 PRKAG2 BCL9 GJA1 GJA3 CTNNB1 PRKAG3 GJA5 GJA8 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260410%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE6D ADCY1 ADCY8 ADCY6 PDE8A ADCY9 PDE1C PDE3B GUCY1A2 GUCY1B1 PDE1B CHRNA7 GRIN1 PDE1A PDE4B PDE3A ADORA2A PDE4A PDE5A PRKG1 PDE7B PDE7A PDE11A PDE4D PDE6C PDE6A PPP1R1B DRD2 PDE6H ADCY3 PDE6G PDE10A PDE12 PDE9A DRD1 HEL-S-7a CAMK2A PDE2A GRIN2B CREB1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway UBA7 PARK2 UBE2G1 UBE2G2 SNCAIP CYCS LRRK2 UBB PINK1 CCNE1 SLC6A3 MAPK14 MAPK12 UBE2L6 CASP2 CCNE2 SNCA GPR37 EPRS1 CASP9 MAPK11 SYT11 CASP6 UBE2J2 CASP3 SEPT5 HEL-117 HEL-S-67p HTRA2 DDC UBE2J1 TH ATXN2 APAF1 MAPK13 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260410%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy PIK3R4 ATG3 RB1CC1 ATG10 ATG12 MAP1LC3A WIPI1 ATG16L1 ZFYVE1 ATG16L2 MTOR ULK2 ULK1 ATG5 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260410%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging IGF1R PTEN MTOR SIRT1 FOXO1 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260410%WP2261%HOMO SAPIENS Glioblastoma signaling MAP2K5 CDK6 PTEN PIK3R2 PIK3C2G PIK3R1 PIK3C2A FOXO4 CBL CDKN2B PRKCZ PIK3C2B MSH6 MDM4 PLCG2 CDK4 CDKN2C FOXO3A PLCG1 SPRY2 FGFR1 PIK3CA IGF1R RB1 PDPK1 CCND1 AKT3 PRKCQ CDKN1A ERBB2 MET EGFR EP300 ERBB3 CCND2 BRCA2 FOXO1 ARAF NRAS NF1 TSC1 MAPK1 HRAS CDKN2A MAP2K6 MAPK3 MAP2K3 MAP2K4 CCNE1 MAP2K1 CDK2 MDM2 MAP2K2 BRAF GRB2 ATM KRAS BRCA1 RAF1 ERRFI1 CDKN1B PDGFRA TSC2 IRS1 PIK3CD PRKCH PRKCB PRKCA PRKCI SRC FGFR2 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260410%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification CALU FGFR3 JAG2 PLAT SOX6 ITGA1 MGP ALPL GJA5 NOTCH1 LPAR1 DLL3 DLL4 VEGFA MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260410%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms SGMS1 YWHAQ YAP1 CTNNA1 PAK6 NF2 MAP4K3 PAK4 ITGB5 ITGB1 ITGB4 ITGB8 ITGB7 HEL-S-31 ACTG2 ITGB6 MAPK10 WWTR1 ACTA2 ITGB3 ACTG1 MAPK8 LIMD1 PAK1 CTNNB1 PS1TP5BP1 SRC TEAD2 LATS1 TEAD3 MAPK9 TEAD4 MAP4K1 MAP4K2 ACTA1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260410%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy TGFB1 STAT3 MYEF2 RASGRF1 PPP3R1 NFKB1 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260410%WP4217%HOMO SAPIENS Ebola virus infection in host ACTN1 RIGI CTSL CAV3 TIAM1 VPS39 PIK3R3 PIK3CA IGF1R FLNA FLNB HAVCR2 VAV2 EGFR RHOB NPC1 EP300 MAPK1 MAPK3 VPS4A CREBBP ACTN4 ITGB3 HLA-G PIK3CD SCIN CLEC10A ICAM3 RAC1 KPNA1 CD300A RFC1 TIMD4 CD209 CLEC6A ASGR1 IQGAP1 HAVCR1 HLA-DQB2 DAB2IP MBL2 RAB9A CAV2 RAB5A TYRO3 C1QBP PIK3R2 PIK3R1 SOCS3 CLEC4M EIF2AK2 CDC42 ICAM2 STAT1 ARHA RASA2 NEDD4 CLTCL1 HLA-B NFKB2 REL MERTK HLA-C HLA-A VPS11 HLA-F VPS16 ITGB1 VPS18 VPS33A HLA-E VPS41 HLA-DMA ACTG1 ITGAV ITGA4 ITGA2 PAK1 ITGA1 TBK1 PS1TP5BP1 BST2 IKBKE CLTC ADAM17 CLTB RELB PRKRA ITGA6 CLTA IRF3 EIF2S1 IRF7 TLR4 MFGE8 HLA-DOA HLA-DOB HLA-DPA1 HLA-DQB1 HLA-DMB HLA-DQA2 HLA-DQA1 HLA-DRB5 NPC2 HLA-DPB1 HLA-DRA HLA-DRB1 NFKB1 RAB7A IL4 TFAP2A AXL TSG101 RELA FOLR1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders PTH FGFR3 KL DMP1 ROS1 SPP1 CCND1 ENPP1 SLC34A1 CYP27B1 CYP24A1 ALPL FAM20C SLC34A3 CDKN1A NFKB2 FGFR2 CYP11B2 NFKB1 GALNT3 ORAI1 FGF23 FOXP3 IN COVID 19%WIKIPATHWAYS_20260410%WP5063%HOMO SAPIENS FOXP3 in COVID 19 STAT3 IL6ST FOXP3 CD80 IL6 IL2RG IL2 STAT5B IL7R IL2RA IL2RB IL6R TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260410%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling IKBKB MAPK1 MAPK3 NFKB2 JUN TRAF1 NFKB1 TRAF5 MAPK14 RIPK1 MAP3K14 BIRC2 BIRC3 HDAC1 RAF1 GSK3B TNF MAPK8 NFKBIB CASP8 TRIM63 CTNNB1 TRAF2 CASP3 RAC1 CHUK RELA FADD TNFRSF12A MAPK9 MAP3K7 RELB NFKBIA TWEAK TRAF3 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260410%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260410%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMRK1 TDO2 AADAT HAAO AFMID NMNAT1 NAPRT KYNU NMRK2 NAMPT KMO NADSYN1 NMNAT3 NMNAT2 IDO1 HEL-S-90n VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260410%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism LPL RETSAT SCARB1 DHRS3 RBP7 RBP2 CYP2E1 CD36 NR1B3 MAPK1 CYP26A1 CYP26B1 RXRB RXRA RXRG ABCG8 ADH1A NPC1L1 ABCG5 DGAT1 SULT2B1 SDR16C5 SULT1A1 RDH8 HEL-S-53e RLBP1 AWAT2 RPE65 BCO1 RDH12 RDH10 RARA ALDH1A3 RBP1 RDH5 LRAT HEL-S-4 CRABP2 CRABP1 ALDH1A2 RARB RBP4 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260410%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 ID1 HFE2 HFE HAMP BMP6 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260410%WP5293%HOMO SAPIENS Acute myeloid leukemia MYC PIM2 PIK3R2 PIK3R1 CEBPE BAD EIF4EBP1 IL3 STAT3 MTOR ZBTB16 RPS6KB1 CEBPA PIK3R3 FLT3 PER2 PIK3CA BCL2A1 ITGAM CCND1 PML AKT3 FCGR1A CHUK KIT MPO IKBKB ARAF IKBKG NRAS MAPK1 HRAS MAPK3 MAP2K1 RPS6KB2 MAP2K2 BRAF NFKB1 CSF2 SPI1 GRB2 KRAS SOS1 RAF1 SOS2 RARA CD14 JUP NR1C2 PIK3CD PIM1 TCF7L2 RUNX1 TCF7L1 CCNA2 CSF1R RELA LEF1 STAT5B RUNX1T1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4224%HOMO SAPIENS Purine metabolism and related disorders RRM2B HPRT1 MOCOS DGUOK AOX1 TPMT AMPD1 PFAS APRT XDH PAICS PNP ADSL IMPDH1 HEL-S-70p ADSS ADA 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260410%WP5546%HOMO SAPIENS 22q11 2 distal CNV RPS17 RPS16 RPS19 SNW1 RPS18 CD79A RPS11 RPS10 SNRNP200 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA PPIB RPS15A RPS3 RPS2 RPS27A RPS26 LRP4 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 CAMK1 MAPK1 IQUB PTPA MDM2 ROPN1L RSPH6A NME5 HEL-S-125m SNRPB2 AQR DYDC1 BCR CAMK4 ELOC RSPH14 RPS6 CBL RNF19B VPREB1 SNRPD2 RBX1 SNRPD1 CWC22 SNRPD3 CRNKL1 PDIA4 RAB36 SNRPG PPIE SNRPE NEDD4 SNRPF SNRPB UBA6 CABP1 DNAJB13 PRPF8 AK8 CWC15 WDR57 TDRD3 GGTLC2 ZNF280A DHX16 HEL-S-107 ARIH1 CCDC116 BUD31 HYOU1 PLRG1 IGLL1 YDJC CANX SNRPA1 RBM22 SF3B5 SF3B2 PPM1F RNF113A PAK1 RILP UGGT1 PPIL1 SF3A1 SF3A2 CDC5L IGLL5 PHF5A YPEL1 RSPH9 PPIL4 PPIL6 RSPH3 PARK2 CD79B CHEK1 SDF2L1 XBP1 GNAZ PDIA2 DNAJB11 UBE3A HEL-S-89n SOX9 SF3B1 HEL-S-99n CAMK2A RPS15 XAB2 RPS14 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260410%WP1584%HOMO SAPIENS Type II diabetes mellitus PRKCZ TNF IKBKB IRS1 INSR MAPK8 MAPK1 PDX1 MTOR MAFA PHKA2 SLC2A4 SURF1 INS-IGF2 SOCS4 PIK3R5 SLC2A2 CACNA1A IL3 SIGNALING%WIKIPATHWAYS_20260410%WP286%HOMO SAPIENS IL3 signaling IL5RA PIK3R2 YWHAQ PIK3R1 BCL2 CXCL8 CBL BAD IL3 FYN INPP5D MAPK1 STAT3 PTPN11 FOS HRAS ENPP3 MAPK3 PTPN6 JUN MAP2K1 BCL2L1 IL3RA TGFB1 CSF2RB LYN GRB2 SOS1 RAF1 HEL-S-1 PIK3CD MAPK8 CRKL SYK SRC JAK1 CD69 GAB2 CCR3 VAV1 STAT5B RAPGEF1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260410%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria COX11 ATP5PB ATP5F1D ATP5F1E ATP5PO NDUFB9 UCP2 UCP3 SDHC SDHD SDHA SDHB SLC25A5 UCP1 SLC25A4 SURF1 NDUFA12 ATP5IF1 NDUFC2 ND3 NDUFC1 SLC25A14 NDUFS6 ATP5J NDUFS5 ATP5H NDUFS4 SLC25A27 NDUFS3 ATP5MG ND1 ATP5MF NDUFS1 ATP5ME DMAC2L ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 NDUFA11 NDUFB10 COX6A1 NDUFB6 COX6A2 NDUFB5 SLC25A6 NDUFB4 COX6B1 NDUFB3 COX7A2L NDUFB2 UQCRC1 NDUFB1 COXFA4 UQCRC2 NDUFV3 UQCRB NDUFV2 COX7A2 NDUFA7 COX7A1 UQCRH COX3 NDUFA6 COX17 ZNF183 NDUFA3 UQCRQ COX7B NDUFA2 COX4I1 ND4L ATP5G1 COX7C SCO1 NDUFA9 CYB HEL-S-271 NDUFA5 NDUFAB1 COX8A NDUFS8 UQCR11 UQCR10 COX5A NDUFA13 UQCRFS1 ATP8 ATP6 ATP5MC2 ATP5MC3 NDUFA10 HEL-S-123m COX2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260410%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PPP1CC GJB1 ADCY1 ADCY8 RAP1A ARAF PRKACG MAPK1 MAPK3 GRIN1 MAP2K1 MAP2K2 ACTG2 HEL-S-80p CALM1 RAF1 DRD2 ACTG1 GNAI1 DRD4 CAMK4 PRKCB PRKCA PS1TP5BP1 DRD1 GRIA2 PPP1R1A GNAS GRIA3 CAMK2A GRIA4 CREB1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260410%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta MIA3 TMEM38B COLGALT1 IFITM5 CRTAP P3H2 P3H1 LOX PLOD2 BMP1 COL1A1 COL1A2 P4HA2 PLOD1 ADAMTS2 P4HA1 PPIB LRP5 LRP6 TNFSF11 TNFRSF11B WNT1 SP7 MBTPS1 FZD1 TNFRSF11A MBTPS2 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260410%WP2369%HOMO SAPIENS Histone modifications H3C15 H4C9 HIST1H4L EZH2 MLL2 AEBP2 KMT2E SETD4 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L PRDM2 SMYD2 KMT5B SET EHMT1 SMYD4 SMYD3 H4C7 KMT5C SETD1B SETD1A SETDB2 SETMAR ASH1L SETBP1 KMT2A SETDB1 SETD5 SETD2 EED EZH1 SUV39H2 SUV39H1 SETD7 KMT2C SMYD1 H3C8 H3F3B LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260410%WP5146%HOMO SAPIENS Lung pathology of COVID 19 CSF2 CGAS MITA TLR3 TNF IFIH1 CXCL11 MAVS IL18 CCL2 RIGI CXCL9 TBK1 IL1B IL6 TLR8 IRF3 NFKB1 TLR7 TRANSLATION FACTORS%WIKIPATHWAYS_20260410%WP107%HOMO SAPIENS Translation factors EEF1A1 EIF5A EIF6 EIF4EBP1 EIF2AK2 EIF4A2 EIF4E EIF4B PABPC1 EIF4G1 EIF3S3 EIF3F GSPT2 EIF3D SUI1 EEF1B2 EIF3CL EIF4EBP3 EIF2B1 EIF2B3 EIF4A1 PAIP1 CLUH EIF1AY EIF3A EIF1AX EEF1G EIF5 EIF2AK1 EIF2S3 EIF3S2 EEF1A2 EIF3J EIF3G ETF1 EIF3E EIF3C EIF4EBP2 EIF2B5 EIF3B EIF2B2 EEF2K EIF2S2 EEF2 EIF2S1 EIF5B EIF4H OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260410%WP1434%HOMO SAPIENS Osteopontin signaling MAPK1 MMP9 MAP3K14 CHUK MAPK3 RELA ITGB3 MAP2K1 SPP1 IKBKB ITGAV NFKB1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies S1PR5 S1PR4 MS4A1 ITGB1 BTK HEL-S-171mP ITGA4 S1PR1 S1PR3 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260410%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 ACE2 AGTR1 MGRA REN IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260410%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity FCER1A IL1R1 MMP9 MYD88 PLA2G7 HBEGF S100A9 TIMP1 F2R IL18 CCL2 IRAK1 HEL-S-134P IL1B F2 IFNG TLR1 CCR3 NFKB1 NLRP3 PIK3CA DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260410%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development HES5 CDK6 DCAF7 PSENEN DYRK1A CDK4 MTOR SPRY2 NEUROG2 AMPH NFATC1 CRY2 TFDP1 TFDP2 GSK3B RBL2 CCND1 CASP9 DNER CASP3 LATS2 AKT1S1 EIF2B5 REST RBL1 LIN9 E2F5 RBBP4 FOXO1 TSC1 SIRT1 APP E2F4 FGF2 DEPTOR CDKN1B TSC2 RPTOR MLST8 PSEN1 NOTCH1 CSNK1A1 LIN54 GMNN H3F3B LIN52 CREB1 TFDP3 BACE1 LIN37 HES1 TFAP4 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260410%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease DMPK HP1BP3 HSPB3 HEL25 MYOD1 tmp_locus_29 NOTCH3 MEF2C LMNA H2AZ1 LBR MYOG ACTA1 HSPB2-C11orf52 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260410%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling PLG TLR4 MYD88 IKBKB HEL-S-78p CCL2 IKBKG ARHA NOS2 IL6 REL NFKB1 IRAK2 PIK3CA LBP TICAM2 ITGAM PLAT TLR3 LY96 TNF CD14 FGA FCER1G SYK CXCL3 IRAK1 SRC TYROBP CHUK IL12B IFNB1 RELA IRAK4 TICAM1 TIRAP IRF3 TRAF6 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260410%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX5 PTGS2 ALOX15 FADS2 ALOX12 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260410%WP5390%HOMO SAPIENS Pancreatic cancer subtypes GPR87 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 FAM83A PLA2G10 TFF2 KRT20 LGALS4 LYZ VSIG2 AGR2 AGR3 FAM3D CST6 KRT6C SERPINB3 BTNL8 REG4 KRT7 ANXA10 LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 KRT6A DHRS9 SCEL S100A2 AREG CYP3A7 TNS4 FGFBP1 CDH17 SPRR1B TSPAN8 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism CD36 APOB LDLR ABCA1 APOA4 HMGCS1 FABP2 HMGCR MTTP TM7SF2 HSD17B7 SAR1B ABCG8 SLC27A4 NPC1L1 ABCG5 DGAT1 MGAT1 ACAT2 IDI1 FDPS MVK CYP51A1 DHCR24 MSMO1 SQLE EBP PMVK SC5D MVD DHCR7 LBR FDFT1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 MIF AIFM1 GLYCINE METABOLISM%WIKIPATHWAYS_20260410%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260410%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260410%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DCTN6 CDK5 DCTN5 YWHAQ DCTN1 DCTN4 HEL2 HEL-S-77 HEL-S-1 YWHAG NDEL1 DYNC1H1 YWHAZ PAFAH1B1 DISC1 DBH DDC DCTN3 TH PPP2CA FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260410%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 STAT3 IL10 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260410%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia IL1A EP300 SMAD2 IKBKB MAP1LC3A IKBKG ACVR2A STAT3 FOXO3A MTOR NFKB2 IL6 REL CEBPB NFKB1 IL6R TNFRSF1A GDF8 IL1R1 IGF1R IGF1 TNF MAPK11 RPTOR TRIM63 FBXO32 MLST8 JAK1 CHUK IL1B SMAD4 RELA TNFRSF12A AKT1S1 RELB NFKBIA TWEAK PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260410%WP4022%HOMO SAPIENS Pyrimidine metabolism ENPP3 ENTPD1 ENTPD3 NME3 CTPS2 CTPS1 NME4 DCTD NME6 CMPK1 CMPK2 UPRT DCTPP1 POLR2J3 DUT DTYMK POLR2J2 POLR3A POLR3B POLR3D POLR3H NME7 POLR3K POLA1 RRM2 NME2 POLR2A POLR2B POLR2D CAD POLR2G POLR2H POLR2I RRM1 RRM2B POLR2J DPYS POLR2K DPYD POLR2L HEL74 UMPS PRIM2 TYMP NT5M DHODH POLA2 ZNRD1 ENPP1 POLR1A POLR1C POLR1D POLR1F POLR3E CDA TYMS TK1 PNPT1 UCK2 POLR2C UCK1 PRIM1 POLR3GL POLE4 POLD3 POLR3C POLD4 POLR3F POLR3G POLD2 POLE POLE2 POLE3 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260410%WP5603%HOMO SAPIENS Caffeine in myocytes MYH2 MYL11 HEL-S-273 MYL6 TNNI1 RYR3 TNNI2 TNNI3 HEL-S-108 RYR1 ACTG2 TPM3 TNNC1 TPM1 TNNC2 ACTA2 MYL1 TNNT1 MYL2 MYL3 RYR2 TNNT3 MYH8 ACTG1 MYH6 MYH13 PS1TP5BP1 MYH1 MYH4 MYH7 ACTA1 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260410%WP4707%HOMO SAPIENS Aspirin and miRNAs NR1C1 MVD PTGS2 PTGS1 WNT1 NFKB1 VEGFA MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids CERK TSC1 IGF1R SPHK2 MTOR ASAH2 HIF1A CERS1 NFKB1 S1PR1 PIK3CA S1PR3 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260410%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis ABAT SDCBP GRIK2 CABIN1 HDAC10 STIM1 ORAI1 FFAR1 PLCB1 MBD5 EFNB2 FRMPD3 ADARB1 SLC6A13 SLC6A12 NETO2 CPEB3 GRM6 NPTN ADIJ PPP2CA ADII ARHGEF9 SLC7A11 CACNG8 NWD1 SNX27 ERBB4 CACNG2 ATAD1 SYVN1 LHFPL4 SNX14 HOMER1 MAPK1 DLG4 MAPK3 MAP2K1 CREBBP SUMO1 CDH2 HEL-S-162eP AP2A1 GAD1 STAT1 STAT3 GRM3 GABRB3 GABRB2 GABRB1 AP2A2 HDAC1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 PIG59 GABRA3 GABRG3 GABRG2 GABRG1 ARC CRTC1 GRIA2 GRIP1 SLC1A1 SLC1A2 SLC1A3 GRIA3 GRIA4 GRIN2B GRIN3B GRIN3A GRIK5 GRIK3 DKFZp762B153 GRIK1 GRM2 GRM4 GRM8 GRIN1 SH3GL2 PDIA2 SLC6A8 SLC6A1 SLC32A1 SLC6A11 NRG1 PRKCA NRXN3 GABRR3 GLS2 SRC GABRR1 DLGAP3 CAMK2A GNA11 PICK1 FANCONI ANEMIA%WIKIPATHWAYS_20260410%WP5465%HOMO SAPIENS Fanconi anemia EGFR UHRF1 PTEN DCLRE1B UHRF2 REV1 BRCA2 FANCM FANCL FANCB FANCE FANCF ATR RAD51C FAN1 FAAP24 CENPX FANCD2 MAD2L2 CENPS MCM2 USP1 CEBPD HEL-S-125m RAD50 SLX4 BRIP1 MRE11A ATM BRCA1 MEN1 NBN FANCA PALB2 RAD51 UBE2T RFWD3 FANCG CTDP1 FANCC ERCC1 SMARCA4 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1B1 MSRB2 MSRB3 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260410%WP1403%HOMO SAPIENS AMP activated protein kinase signaling NR2A1 PIK3R2 PIK3R1 EIF4EBP1 INSR PRKACG PRKAA1 MTOR PRKAB2 RPS6KB1 PRKAB1 HMGCR PIK3R3 FASN ACACB ACACA CRTC2 STK11 PIK3CA LEP PLCB1 ADIPOR2 STRADA PPARGC1B PRKAG1 PRKAG2 CPT1C PRKAG3 CDKN1A EEF2K INS-IGF2 EEF2 ELAVL1 GYS1 PRKAA2 LIPE SLC2A4RG CAMKK1 CAMKK2 STRADB TSC1 SLC2A4 RPS6KB2 GYS2 ADRA1B LEPR ADRA1A ADIPOR1 TSC2 CAB39 PIK3CD RPTOR CPT1A CCNA2 CCNB1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members PARP10 EP300 ZC3HAV1 TIPARP MAVS IKBKB PARP16 RBX1 PARP12 RIGI IKBKG BTRC ERN1 NFKB2 CLDN6 TFPI2 CREBBP MAP3K14 PARP14 GSK3B TBK1 CHUK SKP1 RELB NFKBIA PARP1 NRF2 PATHWAY%WIKIPATHWAYS_20260410%WP2884%HOMO SAPIENS NRF2 pathway UGT1A9 FTH1 SLC39A8 SLC39A14 SLC6A2 EPHA2 SLC6A3 SLC5A7 HEL-S-10 GCLM SLC6A13 SLC7A11 SLC5A2 SLC6A20 NQO1 GSTM1 UGT1A3 SLC5A5 HBEGF KEAP1 SLC6A19 SLC6A18 HMOX1 GCLC SLC6A17 SLC6A16 SLC5A6 ALDH3A1 SLC5A8 SLC5A9 CES8 CES3 EPHA3 SLC5A3 SLC2A4 SLC5A4 SLC2A9 SLC6A5 SLC6A7 ABCC5 MAFF SRXN1 DNAJB1 UGT1A4 NFE2L2 SLC2A6 CYP2A6 SLC2A2 SLC2A7 SLC2A8 SLC5A1 SLC2A11 SLC2A10 SLC2A13 HEL-S-25 UGT1A1 SLC5A12 SLC5A10 SLC39A9 SLC39A6 SLC39A5 GSTM4 SLC39A2 GSTM3 SLC39A1 GSTM2 SLC39A3 GPX2 GSTM5 GPX3 MAFG SLC39A11 SLC39A10 SLC39A13 HEL-75 SLC39A12 TXN HEL126 AGER CES2 SLC2A12 CES1 GSTT2 FGF13 HSP90AB1 TGFB1 ABCC3 HEL-S-128m ABCC2 TXNRD3 SLC2A14 ADH7 FTL UGT1A7 HGF TGFA MGST3 TGFBR2 MGST2 SLC6A9 SQSTM1 SLC2A3 RXRA GSTA5 GSTA4 GSTA3 SERPINA1 SLC6A8 SLC6A1 SLC6A11 ME1 NRG1 NR1C2 PTGR1 CYP4A11 HEL-S-22 UGT2B7 EGR1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260410%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP27B1 CYP24A1 CYP17A1 CYP4F8 CYP4Z1 CYP7B1 CYP2U1 CYP8B1 CYP27A1 CYP4F22 CYP4X1 CYP11A1 CYP2J2 CYP4F11 CYP27C1 CYP2S1 CYP11B2 CYP4F3 CYP4V2 CYP3A4 CYP2R1 CYP1B1 POR CYP2E1 CYP2A7 CYP2C9 CYP2C8 CYP2B6 CYP2C19 CYB5R3 CYP2F1 CYP2C18 CYP20A1 CYP1A1 CYP26A1 CYP26B1 CYP46A1 CYP7A1 CYP3A43 CYP2A6 CYP2W1 CYB5R1 CYP2A13 CYB5R4 CYP4B1 CYB5B CYP4F2 CYP4A22 CYP4F12 CYP4A11 CYP3A7 CYP51A1 CYP26C1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260410%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit SPN CD3G CD80 BCL2 CD27 CD3E CD3D IL2 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260410%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 ADAM17 AVPR1B GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260410%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs G6PC1 PFKL LIPE GLYCTK GPD2 AGXT AQP9 PGAM1 PCK1 ALDOB FBP1 MGLL PNPLA2 GPD1 HEL-S-87p PKLR KHK ENO1 HEL-S-68p HEL-S-162eP HEL-S-49 AQP7 PC HEL-S-165mP CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260410%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 DAGLA PLCB1 CNR1 CCKBR CCK RYR3 RYR2 RYR1 GNAI1 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260410%WP5175%HOMO SAPIENS Disorders in ketone body synthesis BDH1 OXCT1 ACAT1 HMGCL INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260410%WP5120%HOMO SAPIENS Inclusion body myositis PSEN2 PSEN1 SIRT1 APP NFKB2 PSENEN NFKB1 BACE1 GDF8 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260410%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system VHL HSPA4 EP400 BDNF SNCAIP SMAD2 CDC20 PRKCZ FUS FAT10 MAPRE1 HEL-S-2a BBIP1 MAP1B HEL-S-44 TARDBP SP1 ERG HDAC11 HEL-S-72p OPTN BIRC5 FOXP3 MYH9 GSK3B DLG2 HEL-S-32 SHH MIF AURKA MAPK8 FREP1 ADRBK1 CYBB GRIA2 KAT5 HEL-S-102 HDAC9 POU5F1 GSK3A TUBA1C APC TUBB PARK2 MYD88 EGFR ISG15 CD133 EP300 SQSTM1 BCL2 APOE ITIH4 TUBA4A MAP1LC3A MAP3K5 TUBA2 MAPK1 CSNK2A2 TWIST1 DLG4 HEL113 MAPK3 BAX CFTR SGK1 CSNK2B RHOT1 NR3C1 SNCA SIRT2 DCTN1 IKBKAP VCP NEDD9 KALRN ATXN3 CCDC141 MIIP PRKCE ARID3A HTT HSF1 GARS1 CTNNB1 CNOT6 RAC1 PXN HIF1A HEL-S-67p PTK2B STUB1 HDAC6 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260410%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling TEC CRLF2 TSLP EIF4EBP1 STAT4 FYN STAT1 MAPK1 STAT3 PTPN11 MAPK3 NFKB2 MAP2K1 MAP2K2 NFKB1 MAPK14 LYN FES IL7R MAPK8 SRC JAK1 RELA MAPK9 RPS6 RELB GAB2 BTK NFKBIA STAT5B YES1 LCK PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer TFEB MAPKAP1 PTEN PIK3R2 PIK3R1 FOXO4 BAD FOXO1 EIF4EBP1 NRAS FOXO3A HRAS MTOR RHEB PIK3R3 ULK1 PIK3CA KRAS RB1CC1 GSK3B CDKN1B TSC2 RPTOR GRB10 MLST8 RICTOR HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260410%WP4540%HOMO SAPIENS Hippo signaling regulation SMAD2 PRKCZ CDC42 INSR ARHA NF2 FGFR4 PRKACG KDR PRKAA1 PRKAR1B PRKAR1A MTOR PRKAB2 PRKAB1 FGFR1 FLT1 FLT3 EPHA2 FLT4 PLCB4 IGF1R PLCB1 WWTR1 PLCB2 NGFR GNAI3 PRKAG1 PRKAG2 PRKAG3 TEAD2 LATS1 PRKCQ LATS2 TEAD3 CDH10 TEAD4 CDH11 GNAS CDH12 CDH15 CDH16 CDH17 CDH18 CDH19 KIT PRKAA2 MET EGFR FGFR3 YAP1 NTRK1 NTRK2 PRKD3 CDH9 CDH8 CDH6 PLCB3 GNAL CDH4 CDH2 PDGFRA PRKCH PRKCB PRKCE PRKCA CTNNB1 PRKCI TCF7L2 RAC1 TCF7L1 CSF1R LEF1 FGFR2 CDH24 GNA11 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC3 NQO1 ABCC2 EPHX1 KEAP1 ABCG2 CES1 GCLC HMOX1 MAPK11 MAPK8 GCLM NQO2 FOS HEL-S-22 JUN SRXN1 NFE2L2 MAPK14 MAPK13 ABCC6 MAPK12 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260410%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY4 LPAR4 P2RY2 LTB4R P2RY1 ADORA2B ADORA2A P2RY6 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260410%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260410%WP2333%HOMO SAPIENS Trans sulfuration pathway CBS MTR pcap CTH GCLM SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260410%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization TGFB1 CSF2 CCR1 CCR5 IL2 IL4 CCL4 IL5 CXCR3 CD40LG CCL3 IFNGR1 IFNGR2 IL12B IL18R1 IL12A IFNG CCR7 CXCR4 CCR4 CCR3 CCR2 IL12RB1 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CTNNB1 RB1 CSRP2 PMAIP1 MED1 CCND1 SOX4 MACROH2A1 CDK4 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP69%HOMO SAPIENS T cell receptor signaling CRK PIK3R2 NFATC2 PIK3R1 NCK1 CBL CDC42 FYN MAP3K8 PTPN11 PLCG1 SH2B3 REL NFATC1 MAP3K14 PDPK1 MAPK8 PAK1 ITK CHUK PRKCQ LAT MAP3K7 MAP4K1 NFKBIA CARD11 HEL-S-81p VAV3 BCL10 RIPK2 TRAF6 WAS ATF2 IKBKB IKBKG MAPK1 FOS CD3G HRAS CD3E MAPK3 CD3D JUN MAP2K1 MAP2K2 NFKB1 MAPK14 GRB2 SOS1 RAF1 CRKL GRAP2 CD8A PSTPIP1 LCP2 ICOS RELA MAPK9 PTK2B FYB1 GAB2 VAV1 ZAP70 CREB1 LCK PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies CXCL1 IL17F IL17A CXCL8 TNF IF2B1 IL23R STAT3 IL1B IL12B HLA-C TYK2 IL17RC CCR6 CCL20 IL23A IL12RB1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260410%WP34%HOMO SAPIENS Ovarian infertility CCND2 ZP3 PRLR ZP2 NR1i1 CDK4 TSC1 NCOR1 MTOR PTGER2 CEBPB LHCGR FMR1 SYNE2 DAZL NR3A2 ATM CDKN1B TSC2 SMPD1 NR5A1 RAD51 TBP PGR GDF9 GJA4 FSHR FIGLA DMC1 EGR1 INHA CREB1 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260410%WP1984%HOMO SAPIENS Integrated breast cancer pathway BLM BACH1 CHEK2 PTEN MYC SMAD2 BARD1 BAD PLK1 CDC25B MSH6 MSH2 NUP85 CDK4 NOXA1 HMGCR GRN XRCC3 AURKA RHO SMARCA4 FAU ANXA1 CERK AHR EGFR EP300 FOXO1 BMPR2 ARAF NF1 RRAS TSC1 MAPK1 SIRT1 RHEB JUN CDK2 MDM2 BRAF GDI1 RPP38 KRAS TSC2 IRS1 DAG1 RAC1 JAK1 ZMYND8 NAB1 MAX MAP3K7CL ALKBH1 RALGAPA1 CCNB1IP1 PIAS1 LGALS13 PLK3 CREB1 ERAL1 HIPK2 MYT1 FOSL2 WEE1 EDAR FER PIGR RASGEF1A SELENOK SMAD6 DCAKD PIK3R2 PKIA ITPKC USP15 USP16 USP21 RAP1A CDK7 FILIP1 CDC42 UBE2F STAT1 SP1 TPR MTOR SMAD1 STK11 HDAC1 RB1 TRADD CCND1 PML SMEK1 CASP9 RAD51 PAK1 CASP8 APOBEC3G ZNF655 CSNK1D CASP3 CHUK SMAD4 FADD PPP4R3B TGFBR1 TGFBR2 MAP3K7IP1 GSK3A GADD45A BCL2 CHEK1 BRCA2 BAK1 ATR MYCBP2 MAP3K13 BAX NFKB1 TFPI RAD50 MRE11A ATM BRCA1 RASGRP3 ZMIZ1 DHTKD1 CTNNB1 RALA VEGFA ATF1 FOSL1 BMPR1A NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260410%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP2 MMP9 EGFR MET SNAI1 SMAD2 PECAM1 NRP1 PLXNA4 KDR MAPK1 COL1A1 COL1A2 SEMA3A MAPK3 EGF NFKB2 REL SNAI2 CCNE1 FLT1 MAP2K1 CDK2 PLXNA1 MAP2K2 NFKB1 CTGF CCNE2 CDKN1B AKT3 SRC PLXNA2 RAC1 SMAD4 RELA HGF RELB TGFBR1 TGFBR2 GSK3A CHD2 TGFBR3 VEGFA GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260410%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GPRC5D GABBR1 GRM2 GRM4 GRM8 GRM3 CASR GRM6 GPRC5A GPRC5C GABBR2 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260410%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2J GTF2F2 POLR2K TAF12 TAF13 MNAT1 CCNH CDK7 GTF2H2C_2 TAF7 TAF6 GTF2E1 POLR1A POLR1D POLR3E GTF2H2 GTF2H3 GTF2B POLR2C TAF5 HEL-S-28 POLR3B POLR3D TBP POLR3H POLR3K TAF9 ERCC2 GTF2E2 POLR2A POLR2B POLR2F POLR2G POLR2H POLR2I KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260410%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy SCN8A SCN2A SCN4B KCNQ2 RAB1A ZNF547 TRAPPC3 GIGYF1 FGF13 TRAPPC6B FGF12 KCNQ5 NEDD4 AKAP5 CALM1 SNAP25 DAG1 PRKCE STX1A RAB11A KCNQ3 VAMP2 CAMK2A PRRT2 BACE1 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome CCL3L3 MED1 PIP4K2B CCL14 DHRS11 RPL23 CCL13 TBC1D3B TBC1D3E SOCS7 TBC1D3C CCL18 CWC25 TBC1D3I CCL16 AATF IKZF3 CISD3 CACNB1 ACACA TMEM132E TBC1D3H RDM1 ARL5C C17orf50 GPR179 UNC45B SLC35G3 SRCIN1 SLFN12 PNMT SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 SLFN5 GGNBP2 PGAP3 FBXO47 MLLT6 PIGW CCT6B MRM1 FBXL20 NEUROD2 MIEN1 ZNHIT3 LYZB C17orf78 ASIC2 GAS2L2 HEATR9 TAF15 RASL10B PCGF2 SYNRG EPOP PLXDC1 NLE1 ERBB2 RFFL ARHGAP23 CCL11 TBC1D3K TEC STAC2 CDK12 SPMAP1 PEX12 CCL1 CCL5 CCL7 CCL4 STARD3 CCL2 CCL3 FNDC8 MMP28 CCL15 DUSP14 PPP1R1B GRB7 TCAP CCL8 LHX1 TCF2 CCL4L2 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260410%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 NR3A2 MYC H3Y1 EP300 MYF5 H3Y2 PAX7 MYOD1 DUX4 PPARGC1A TRIM63 FBXO32 CDKN1A MYOG ADRB2 VEGFA RET SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260410%WP4658%HOMO SAPIENS Small cell lung cancer CDK6 PTEN LAMB4 MYC PIK3R2 PIK3R1 CDKN2B CDK4 ITGB1 PIK3R3 TRAF1 TRAF4 TRAF5 LAMC2 PIK3CA BIRC7 LAMC1 BIRC2 BIRC3 RB1 E2F2 E2F3 CCND1 ITGAV CDKN1C CASP9 AKT3 ITGA2 NFKBIB CASP8 TRAF2 CASP3 CHUK CDKN1A FHIT SKP1 ITGA6 NFKBIA APAF1 TRAF3 TRAF6 LAMA5 LAMA1 GADD45B LAMA4 GADD45A LAMA3 GADD45G BCL2 CYCS CKS2 PTGS2 IKBKB IKBKG BAK1 NOS2 LAMB3 RXRB RXRA LAMB2 CCNE1 RXRG LAMB1 BAX CDK2 BCL2L1 NFKB1 CCNE2 ITGA2B CDKN1B COL4A2 PIK3CD CKS1B COL4A1 COL4A4 COL4A3 POLK COL4A6 COL4A5 RELA DDB2 MAX RARB MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX AOX1 GPHN MOCS2 XDH MTARC2 MOCS1 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP3941%HOMO SAPIENS Oxidative damage response GADD45A BCL2 CYCS BAD CDC42 TNFRSF1B PCNA C1S BAG4 BAK1 C1R NFKBIE C2 MAP2K4 C4B_2 MAP3K1 TRAF1 NFKB1 MAPK10 C1QB C1QA TNF CDKN1B CDKN1C CASP9 TRAF2 CASP3 CDKN1A C1QC CR2 C5AR1 C3AR1 APAF1 TRAF3 MAPK13 TRAF6 TNK2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260410%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS2 ALAS1 FECH UROD UROS HMBS CPOX NEPHROGENESIS%WIKIPATHWAYS_20260410%WP5052%HOMO SAPIENS Nephrogenesis BMP7 FGF8 TCF21 FOXD1 GREB1L NOTCH2 MEIS1 WNT9B RSPO3 RSPO1 SIX2 WNT3A OSR1 ALDH1A2 WNT4 FGF20 PAX2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260410%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC6A20 SLC7A7 CLTRN SLC7A9 SLC1A1 SLC3A2 SLC6A19 SLC36A2 SLC3A1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260410%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 SP1 MAFG CYP2E1 MAP2K1 MAFF MAP2K2 NFE2L2 MAPK8 MAFK SIGNALING LIPIDS%WIKIPATHWAYS_20260410%WP5584%HOMO SAPIENS Signaling lipids EPHX2 PLCB1 PTGES PRXL2B HPGD CYP2C9 ALOX5 CYP4F2 PTGS2 CYP2C8 ALOX15 CYP2B6 FADS2 ALOX12 CYP7B1 CYP8B1 GPX4 CYP27A1 LTC4S CYP7A1 PLA2G1B PLA1A GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5292%HOMO SAPIENS Glycosphingolipid metabolism GBA2 NEU3 UGCG NEU4 B3GALT2 GLA B3GALT1 B4GALNT1 ST3GAL5 B4GALT5 UGT8 B3GNT5 A4GALT A3GALT2 B4GALT4 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260410%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 CYP2J2 COX8A HEL-S-22 CYP2C9 CYP2C8 COX5A GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260410%WP661%HOMO SAPIENS Glucose homeostasis INS WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260410%WP4150%HOMO SAPIENS Wnt signaling in kidney disease NPHP3 WNT2B INVS WNT5B ARHA WNT16 LRP5 LRP6 MAPK10 DVL1 DVL2 DVL3 FZD4 MAPK8 WNT1 WNT3 FZD1 CTNNB1 WNT10B WNT10A FZD3 WNT9B FZD2 WNT3A MAPK9 FZD5 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260410%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BBC3 MYC SMAD2 CSNK1A1L BAD MSH3 MSH6 MSH2 ARHA BCL2L11 REL BIRC5 TGFB1 GSK3B CCND1 CASP9 AKT3 MAPK8 TBK1 CASP3 SMAD4 CDKN1A AXIN1 TGFBR1 TGFBR2 APC NTN1 GADD45B GADD45A GADD45G BCL2 CYCS PTGS2 RAC3 ARAF BAK1 APC2 MAPK1 FOS EXOC2 MAPK3 AXIN2 BAX JUN MAP2K1 BRAF MAPK10 KRAS RAF1 PMAIP1 POLK CTNNB1 APPL1 TCF7L2 RAC1 DCC TCF7L1 DDB2 LEF1 MAPK9 RALA CSNK1A1 RALB CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260410%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway TREX1 CGAS IFNA13 ADAR IFNA14 IFNA16 MITA IFNA17 MAVS RIGI IFNA10 TRIM25 IFNA21 AIM2 IL33 IFNA1 PYCARD TRADD POLR3A POLR3B POLR3D POLR3H NFKBIB CASP8 POLR3K TBK1 CASP10 IKBKE CHUK IFNB1 FADD RIPK3 NFKBIA IRF3 POLR2F ATG5 POLR2H IRF7 POLR2K POLR2L ISG15 RNF125 IFNA4 IFNA7 CYLD IFNA6 IFNA2 CCL5 IFNA8 IKBKB ATG12 CCL4 IKBKG POLR1C POLR1D ZBP1 POLR3E IL6 NFKB1 RIPK1 POLR3GL POLR3C POLR3F NLRX1 POLR3G IL18 IF1AA9 IL1B RELA CCL4L2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260410%WP691%HOMO SAPIENS Tamoxifen metabolism SULT1A1 CYP1B1 CYP2E1 UGT1A10 CYP2C9 CYP2C8 CYP2C19 CYP1A1 UGT2B15 UGT1A8 SULT1E1 UGT2B7 SULT2A1 UGT1A4 CYP2A6 CYP3A4 JOUBERT SYNDROME%WIKIPATHWAYS_20260410%WP4656%HOMO SAPIENS Joubert syndrome TMEM67 NPHP1 PDE6D NPHP3 BBS2 NEK8 BBS1 INPP5E TTC8 CETN2 ARHA MKS1 CEP41 MTOR TMEM138 MYO6 TMEM237 UNC119 ZNF423 AHI-1 FLNA SHH SUFU KAT5 PARP1 RAB8A TCTN3 TCTN2 TCTN1 B9D2 CEP97 CC2D2A OFD1 INVS ARMC9 RPGRIP1L CEP164 CCP110 ARR3 ARL2 PCNT RAB3IP RHEB BBS9 BBS7 BBS5 CEP290 BBS4 CPLANE1 RAD50 ATF4 TMEM231 MRE11A TMEM17 ATM B9D1 PDE6A DVL1 PDE6G RP2 DVL3 TMEM216 PIBF1 PCM1 CEP104 ARL3 ARL13B T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer TNFSF6 TNFRSF9 FAS CXCL12 NR1i1 IL13 CD40LG LGALS9 CTLA4 CCL17 VEGFB VTCN1 IL6 VSIR TNLG5A VEGFC TIGIT TNFRSF4 CCL22 VEGFD HLA-A B2M PDCD1 PDCD1LG2 FAP ENTPD1 IDO1 PDGFD PDGFC TGFB1 NT5E CD40 CD80 PDGFA IL4 SHH TNLG2B CD226 ARG1 ICOS CXCR4 IL10 HAVCR2 VEGFA SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260410%WP615%HOMO SAPIENS Senescence and autophagy in cancer GABARAPL1 RNASEL PTEN MMP14 TNLG1B INHBA IGFBP5 INS SPARC GABARAP VTN IL3 CDC25B PCNA IL24 CXCL14 IRF1 MTOR CEBPB MAP1LC3C ULK1 CXCL1 TGFB1 IGF1R KMT2A RB1 RB1CC1 GSK3B IGF1 BMI1 HMGA1 SMAD4 IFNB1 CDKN1A AKT1S1 ATG5 IRF7 IL1A BMP2 SERPINB2 SH3GLB1 DKFZp762B153 ATG3 SQSTM1 CD44 BCL2 CXCL8 UVRAG ATG10 AMBRA1 ATG14 ATG12 MAP1LC3A ATG16L1 CCL3 MAPK1 HRAS CDKN2A COL1A1 COL3A1 IL6 MAP2K3 THBS1 IGFBP7 JUN MAP2K1 MDM2 ING1 IFI16 BRAF IL6R CREG1 MAPK14 RSL1D1 COL10A1 RAF1 PLAT LAMP2 SLC39A2 CDKN1B SLC39A1 SLC39A3 MLST8 IL6ST SRC IL1B IFNG GABARAPL2 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260410%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis CSN1S1 PRKAA2 EIF4A2 TSC2 PRKAG1 PRKAG2 EIF4E RPTOR CSN2 PRKAA1 PRKAG3 MLST8 MTOR PRKAB2 RPS6KB1 CSN3 PRKAB1 EIF4G1 EEF2K EEF2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260410%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling PRKAA2 MYC CD80 SLC2A3 GSK3B TSC2 HEL-S-133P PFKFB4 NR1i1 HK3 TSC1 CYP24A1 MTOR RELA IL12A RXRA IL10 HLA-DRA PDHA1 PIK3CA NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260410%WP2882%HOMO SAPIENS Nuclear receptors meta pathway UGT1A9 FTH1 SLC39A8 IP6K3 SLC39A14 UGT2B4 SLC6A2 EPHA2 SLC6A3 SLC5A7 HEL-S-10 FGF8A SLC6A13 SLC7A11 SLC7A5 SERPINB2 HBEGF KEAP1 PTGS2 FOXO1 HMOX1 SLC6A17 SLC6A16 SLC5A6 ALDH3A1 SLC5A9 CES8 CES3 EPHA3 SLC5A3 SLC5A4 SLC2A9 SULT2A1 SLC6A5 SLC6A7 ABCC5 PTPA MAFF SRXN1 DNAJB1 NFE2L2 SLC2A6 SLC2A7 SLC2A8 SLC2A11 PDK4 SLC2A10 SLC2A13 SULT1A1 HEL-S-25 UGT1A1 SLC5A12 SLC5A10 IL17B PCK1 GPX2 GPX3 MAFG IL1B HEL-75 TXN SLC2A12 NR1i1 ALOX5AP FGF13 PDE4B ABCC3 ABCC2 ABCB1 ABCB4 PPARGC1A BAAT ABCB11 CYP8B1 ADH7 SLCO1B1 SLC27A5 FTL SLC6A9 SLC27A1 SQSTM1 DBI SLC2A3 CYP2C9 CYP2B6 CYP2C19 CCL2 FABP1 SNAI2 CYP7A1 PLTP SERPINA1 ABCG8 ABCG5 GCC1 NR3C1 APOA2 APOC3 APOA5 SLC6A1 SLC6A11 SMC1A CDKN1B JUNB GPAM KAT2B CYP4A11 KLK15 SRC CPT2 ACADM EGR1 SMARCA1 NR0B2 JUND MYC CDC2 CDK4 NR1H3 NR1C1 SCD FASN IGFBP1 GCLM NCOA6 MYOF ALAS1 SLC5A2 CYP3A4 SLC6A20 NQO1 GSTM1 AHR UGT1A3 SLC5A5 EGFR CAP2 CYP1B1 EP300 EHHADH AIP SLC6A19 FKBP5 SLC6A18 GCLC CDC37 CYP1A1 AHRR SLC5A8 SLC2A4 JUN CCL20 SLCO2B1 UGT1A4 CYP2A6 SLC2A2 DNAJC7 SLC5A1 SLC39A9 SLC39A6 GSTM4 SLC39A5 GSTM3 SLC39A2 GSTM2 SLC39A1 SLC39A3 GSTM5 CYP3A7 SLC39A11 SRPX2 SLC39A10 CPT1A SLC39A13 SLC39A12 NR1H4 HEL126 AGER CES2 CES1 GSTT2 SP1 STAT3 B3GNT5 NFKB2 HSP90AB1 ACOX1 TGFB1 HEL-S-128m BIRC2 BIRC3 TNF TXNRD3 CCND1 CDKN1C TNFAIP3 SLC2A14 THBD EPB41L4B ARL5B RGS2 DNER ENC1 ANKRD1 IL12B TNS4 UGT1A7 IL12A SRGN IL11 HGF FGFBP1 TGFA EDN2 TSC22D3 MGST3 POU5F1 TGFBR2 NAV3 MGST1 TGFBR3 ADGRF4 MGST2 CDC42EP3 SCNN1A PMP2 ANGPTL4 MFGE8 SLC26A2 GADD45B ABHD2 NR1I3 AMIGO2 BHLHB2 PRRG4 FGD4 GPR153 SERTAD2 STOM NCOA1 PPP1R14C CAVIN2 PTGES3 PLK2 NR1i2 DNAJC15 KTN1 ACKR3 ZIC2 S100P SPRY1 CPEB4 RXRA BAX GSTA5 GSTA4 GSTA3 SLC6A8 ME1 IL2 NRG1 NR1C2 PTGR1 POLK CYP4F12 HEL-S-22 IFNG UGT2B7 SLC19A2 HES1 ALSTROM SYNDROME%WIKIPATHWAYS_20260410%WP5202%HOMO SAPIENS Alstrom syndrome ALMS1 IFT172 IFT27 E2F4 CEP192 RABL2B BLOC1S4 ACTN4 VCPIP1 BLOC1S6 BLOC1S1 CIMAP3 SNAPIN TFDP2 RFX2 VCP DTNBP1 RFX3 IFT25 RFX1 TUBG1 SMO DNM3 IFT81 RILPL1 GPR161 PTCH1 MYO5B STX5A IFT74 CEP19 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260410%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 EBI3 CD79A CXCL12 C4A CXCL13 IRF8 CD40LG PTPRC SH2D1A HEL-S-72p CD82 PRDM1 MAF TNF SYK ITGAX TNFSF13 BLNK BCL6 IL12A BTLA CCR7 CR2 MS4A1 IFITM1 IL10 IFIT2 TMSB10 TLR7 CD19 TLR4 MFGE8 ISG15 CXCR5 TNLG7A CD22 ICOSLG FOXO1 XBP1 CCL19 IL6 IL-21 CCL21 PDCD1 CRP TBX21 GPR183 CD40 BCR CD80 IL2 IL4 IRF4 BACH2 PAX5 AID ZEB2 FCRL5 CD1D ICOS SELL IFNAR2 SLAMF7 CD69 IFNG CXCR4 HEL-S-62p CR1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260410%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GH1 GNRH1 IGF1 SST GHRH NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260410%WP4753%HOMO SAPIENS Nucleotide excision repair CUL4A MNAT1 CCNH CDK7 GTF2H2C_2 RPA3 RPA1 RBX1 PCNA CETN2 GTF2H2 GTF2H3 DDB1 GTF2H5 XPA CUL4B POLE4 POLD3 POLD4 POLD2 XPC POLE RFC3 RFC4 LIG1 ERCC1 RFC1 ERCC2 RFC2 DDB2 POLE2 POLE3 ERCC5 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism A3GALT2 ST8SIA1 FUT1 SLC33A1 B3GALT4 ST8SIA5 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 ST3GAL5 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer ADAM10 MYC CCL1 FOXO1 CCL5 CCL4 FCGR3A CCL2 CCL3 MICA TIGIT CSF2 TNF NCR1 NCR3 BMI1 CD226 IFNG PRF1 ADAM17 GATA2 KLRK1 NCR3LG1 MICB CD96 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260410%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis NR3C1 LEP PPARG PPARGC1A TNF FOXO1 IRS1 INSR MAPK8 TWIST1 SLC2A4 CEBPA IL6 RXRA CEBPB LPIN1 CREB1 CEBPD PCK2 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260410%WP2197%HOMO SAPIENS Endothelin pathways HEL-S-14 RIIAD1 NPY ADRB1 CALCA CALCRL EDN1 MAPK1 MAP2K1 NPY1R ADRA1A MYLK PTGIR GNA15 CALM1 PLCB1 MYL1 RAF1 GNG13 ECE1 GNAI1 GNB5 PRKCA HEL-S-7a EDNRA EDNRB GNAS RAMP1 CAD ATP2A2 COX2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260410%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 EPHX2 LPL APOA2 APOA4 GHR PCSK9 USF1 APOB LDLR LIPC GPIHBP1 PLTP DNA MISMATCH REPAIR%WIKIPATHWAYS_20260410%WP531%HOMO SAPIENS DNA mismatch repair POLE4 POLD3 POLD4 RPA3 RPA1 POLD2 PCNA PMS2 POLE MSH6 MSH2 RFC3 RFC4 LIG1 RFC1 RFC2 POLE2 POLE3 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260410%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IL17F TLR4 IL17A CSF2 TNF STAT4 STAT1 IF2B1 STAT3 RORC IL12B IFNG TYK2 IL23A STAT5B IL12RB1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260410%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan TDO2 HAAO KMO AFMID NMNAT1 NADSYN1 KYNU HEL-S-90n BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260410%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation FGFR4 MAPK1 FXR1 FGF8A MAPK3 SLC10A2 LDLR CYP7A1 ABCB11 ABCG8 ABCG5 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260410%WP5178%HOMO SAPIENS Disorders of fructose metabolism G6PC1 PFKL HEL-S-53e KHK GLYCTK SORD SLC2A2 HEL-S-49 ALDOB FBP1 SLC5A1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway NQO1 AHR UGT1A3 SERPINB2 EGFR CAP2 CYP1B1 EP300 UGT1A9 AIP NCOA1 CDC37 PTGES3 CYP1A1 ALDH3A1 AHRR CES3 BAX JUN UGT1A4 NFE2L2 TGFB1 UGT1A1 IL17B IL2 TNF CDKN1B IGFBP1 JUNB POLK SRC MYOF IL1B IL12B UGT1A7 IL12A IFNG JUND MGST1 HES1 SLC7A5 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260410%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GNA15 TRPC3 PLCB3 PLCB1 PLCB2 HOMER3 CA8 GRIA2 ATP2B2 RYR3 GRIA3 GRIA4 CACNA1A PLCB4 GNA11 GNA14 COPPER METABOLISM%WIKIPATHWAYS_20260410%WP5189%HOMO SAPIENS Copper metabolism SLC11A2 SLC31A1 ATP7B ATP7A COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260410%WP545%HOMO SAPIENS Complement activation MASP1 C1QB C1QA C1S C4A CFD C1R CFP C2 CD55 C1QC C6 C7 HEL-S-62p C4B_2 C9 C8G MASP2 C8A METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260410%WP5355%HOMO SAPIENS Metabolic epileptic disorders SQOR MOCS3 MPC2 CBS AASS FBP2 XDH PGAM1 SLC7A2 SPCS1 GLUD1 CTH ALDOB HK3 ETHE1 SUOX ENO2 ENO3 GCK HK2 MDH2 PC CDO1 SLC25A5 G6PC1 AADAT DLD GOT2 ACAT1 HEL-S-32 HEL-S-30 PSPH HEL-S-133P PFKP HEL60 SHMT1 SFXN1 SLC25A1 SLC2A3 ECHS1 MOCS2 PHGDH MOCS1 HEL-S-51e SLC2A4 GLDC AMT PSAT1 SLC2A2 ALDH7A1 HEL-S-20 PFKL MPC1 PCK1 DHTKD1 FBP1 SLC25A15 LDHB GLS2 DLAT ARG1 ASL GCDH HEL-S-87p PKLR ASS1 GPHN PGAM2 GPT OTC ENO1 BTD HEL-S-68p PDHA1 HLCS PFKM HEL-S-162eP HEL-S-49 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260410%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells CSF2 KIR2DL1 KIR2DL3 TNF FYN NLRP7 NLRP2 SYK PRKCA TYROBP ELF3 LCP2 RAC1 PRKCQ PLCG1 LAT HLA-C IFNG PTPN6 VAV1 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260410%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP2 CERK PLPP1 SGMS1 SPHK2 SPTLC1 SPHK1 SGMS2 GBA2 SGPP2 SGPP1 UGCG SPTLC2 SGPL1 SMPD1 DEGS2 KDSR UGT8 CERS6 CERS1 CERS2 CERS3 DEGS1 PLPP3 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260410%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates G6PC1 VHL SIRT7 MYC PGAM1 FOXO1 OTUB2 USP37 HEL-S-133P FBP1 USP44 USP28 USP19 KDR U2AF2 MTOR OTUD6B HIF1A HK2 OTUD7B HEL-S-68p VEGFA PIK3CA NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260410%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260410%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO SLC26A1 PXMP2 GOT2 HAO1 HOGA1 AGXT PRODH2 HEL-S-133P HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260410%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 LAMA5 EDAR SNAI1 MYC NCAM1 TNLG7C INHBA CCND2 GTPBP4 ITGB1 FOXI3 RUNX2 NFKB1 LRP5 TP63 GJB6 PDGFA PDGFRA SHH CCND1 SMO FZD1 PTCH1 CTNNB1 LEF1 FGFR2 BMP4 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260410%WP2007%HOMO SAPIENS Iron metabolism in placenta HEL60 TF STEAP3 TFRC SLC40A1 HEPHL1 SLC11A2 TFR2 MCOLN1 HAMP IREB2 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260410%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFATC3 CD8B1 NFATC1 NFATC2 STAT3 PTPN11 BATF CD8A CD3G CD3E CD3D IFNG HLA-A JUN PDCD1 PDCD1LG2 HLA-DRB1 ZAP70 NFAT5 NFKB1 NFATC4 LCK SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260410%WP2267%HOMO SAPIENS Synaptic vesicle pathway SYN1 AP2A1 AP2S1 SLC17A6 SLC17A7 CLTCL1 SLC22A3 CPLX2 CLN8 CPLX1 RIMS1 SLC17A8 AP2A2 SLC18A1 UNC13C SLC18A3 SYT1 SLC32A1 SYP SNAP25 SYN2 STX1B STX3A SLC18A2 DNM3 SLC38A1 AP2M1 NAPA STX1A SLC1A3 UNC13B CLTC HEL-S-67p UNC13A SLC25A4 STXBP1 VAMP2 CLTA STX2 CACNA1B CACNA1A HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260410%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming PIP4K2A CADM1 HDAC2 HDAC1 EP300 EZH2 TET2 IFITM3 ANKRD13C IRS1 NOL9 CREBBP GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260410%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells GNA15 PLCB3 DCT PLCB1 PLCB2 GPR143 POMC PMEL ARRB2 PRKCB TYRP1 MC1R PRKACG ADCY9 ASIP GNAS TYR CREB1 VEGFA PLCB4 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260410%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways PTEN PIK3C2G PIK3C2A PIK3C2B BAD PRKAA1 HMGCS1 PRKAB2 PRKAB1 HMGCR SREBF2 PIK3R3 NEUROD1 PIK3R5 PIK3CA PRKAG1 PRKAG2 SIN3A ABCG4 PI3 KIF5A RAB3GAP1 PRKAG3 SLC12A2 REST EGFR IKBKB TSC1 MAPK1 MBP HRAS CYP46A1 MAPK3 IL6 RHEB MAP2K4 MAP2K1 MAP2K2 NR1H2 MAPK10 DEPTOR RAF1 TSC2 PIK3CD RPTOR RPS6KA5 MLST8 CYP51A1 IL1B DHCR7 CREB1 PIK3R4 BDNF PIK3R2 PIK3R1 EIF4EBP1 MAP3K10 EIF4E SP1 BCL2L11 MTOR RPS6KB1 GABRB3 GABRB2 GABRB1 HDAC2 HDAC1 GABRE GABRQ C1QA GABRA2 PPARGC1A AHI-1 GABRP SLC12A5 GABRA6 GABRA5 AKT3 GABRA4 MAPK8 GABRA3 GABRG3 GABRG2 CASP8 GABRG1 CASP3 AKT1S1 PRKAA2 BCL2 HEL-S-29 APOE ABCA1 NTRK2 OPA1 EGF BNIP3 BAX BCL2L1 NFKB1 ABCG1 HTT MAPK9 RICTOR HAP1 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260410%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 ABCA1 ELOVL4 MYLIP ELOVL3 ACSL1 HMGCS1 NR1H3 FADS1 CYP46A1 SOAT1 HMGCR SOAT2 TM7SF2 SREBF2 HSD17B7 SCD FACL4 FASN NR1H2 CH25H GGPS1 ACAT2 ABCG1 FADS2 ELOVL5 ELOVL2 IDI1 CYP27A1 FDPS MVK CYP51A1 DHCR24 MSMO1 SQLE EBP PMVK SC5D MVD DHCR7 LBR FDFT1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260410%WP5604%HOMO SAPIENS Sickle cell disease TLR4 HBA2 IL1B HBB IL18 FELBAMATE METABOLISM%WIKIPATHWAYS_20260410%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260410%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF3F EIF3D SUI1 EIF3CL EIF3A EIF1AX EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3E EIF3C EIF3S3 EIF3B EIF2S2 EIF2S1 CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260410%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CRHR1 FOSB PLCG2 ARHA SP1 PLCG1 HSD3B1 ACACA TGFB1 GSK3B ECE1 GNB2 CASP9 GNAI1 GNB3 ARRB2 MAPK8 GNB5 CYP11A1 CRHBP CASP3 KRT1 PRKCQ IVL GNAO1 KRT14 GNB1 GNAS CRH NFKBIA CYP21A2 PARP1 TCF4 TLR4 PRKAA2 BCL2 CXCL8 POMC MAP3K5 MAPK1 FOS TRIM28 ERN1 MAPK3 STAR GNAZ SULT2A1 MAP2K1 BRAF NFKB1 MAPK14 RAF1 IL2 IL18 JUP CASP12 JUNB GJA1 PRKCB CRHR2 PRKCA TFAP2A CTNNB1 HSD3B2 PRKCI RELA MAPK9 CACNA1H CAMK2A JUND CREB1 GNA11 FOSL2 FOSL1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260410%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ MAPK1 MAP3K14 CHUK MAP2K6 RAF1 NFKBIA IKBKB MAP3K1 IKBKG NFKB1 TRAF6 RRAS CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260410%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP2 SCN10A MMP9 SCN8A BDNF MMP14 SLC2A3 AGER PRKCZ MMP21 NOS2 MMP20 MMP24 MMP27 MMP28 PRKD3 MMP10 MMP11 MMP16 MMP15 MMP17 MMP19 MMP25 MMP23B SNAP25 TRPA1 SORD PRKCH PRKCB TRPV1 PRKCE MMP3 PRKCA PRKCI PRKCQ SCN9A HEL-S-62p MMP12 MMP7 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260410%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia MCL1 BCL2 ZAP70 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260410%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 OXCT1 HMGCS1 ACAT2 ACAT1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260410%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway PLPP2 CERK PLPP1 SGMS1 SPHK2 SPTLC1 SPHK1 SGMS2 SGPP2 SGPP1 UGCG SPTLC2 SGPL1 SMPD1 DEGS2 KDSR CERS5 UGT8 CERS6 CERS1 CERS2 CERS3 DEGS1 PLPP3 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260410%WP5360%HOMO SAPIENS KCNQ2 related epilepsies CHRM1 CALM1 AGTR1 KCNQ2 PPP1R10 PPP3CC BDKRB2 PLCG2 CSNK2A1 PRKCA STX1A P2RY1 KCNQ3 SCN1B AKAP5 BACE1 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260410%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling PTEN MYC TCF3 INSR NFKBIE FGFR4 KDR STAT3 MTOR ZBTB16 REL FGFR1 FLT1 ULK2 FLT3 EPHA2 FLT4 PIK3CA IGF1R NGFR GSK3B CCND1 PML AKT3 TTI1 CHUK CDKN1A GAREM2 AKT1S1 NFKBIA APC KSR1 KIT MET EGFR FGFR3 FOXO1 IKBKB IKBKG NTRK1 NTRK2 TSC1 MAPK1 FOS HRAS MAPK3 AXIN2 IL6 RETN RHEB JUN MAP2K1 MDM2 MAP2K2 BRAF NFKB1 IL6R LRP5 LRP6 GRB2 KRAS SOS1 DEPTOR RAF1 SOS2 PDGFRA TSC2 RARA JUP NR1C2 PYGO1 PIK3CD WNT1 BCL9 SALL4 RPTOR CTNNB1 MLST8 SRC CSF1R RELA LEF1 FGFR2 CSNK1A1 RUNX1T1 MRNA PROCESSING%WIKIPATHWAYS_20260410%WP411%HOMO SAPIENS mRNA processing HNRNPK SRSF9 U2AF2 PRMT2 TMED10 YBX1 HNRPR POLR2A CLP1 PAPOLA TXNL4A PSKH1 PRP4K CDC40 PRPF4 PRPF6 PRPF3 SRSF4 SREK1 SRSF6 SRSF7 SNRPA DHX8 CSTF3 CSTF2 SFRS5 SFRS8 CSTF1 DHX38 SRPK2 PTBP1 CPSF4 CPSF1 PRPF40A CPSF3 CPSF2 DICER1 SFRS3 CLK4 LSM2 CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 HNRNPAB SUGP1 CELF2 CELF4 RBM5 RBM17 SNRPB2 SRSF10 PRPF18 NHP2L1 DNAJC8 RNMT CSTF2T U2AF1 PABPN1 TRA2B NUDT21 HNRNPA2B1 RBMX PRMT1 HNRNPH1 SPOP FUS SNRPD2 SNRPD1 SNRPD3 SNRPG SNRPE SNRPF SNRPB PRPF8 WDR57 METTL3 DHX16 SRPK1 NONO SNRPA1 SRP54 SF3B5 SF3B2 HNRNPD SF3A1 SF3A2 PHF5A DDX1 NCBP1 NCBP2 CELF1 DHX15 PPM1G SFPQ SMC1A SUPT5H CLK2 SF3B1 HNRNPL SNRPN MEVALONATE PATHWAY%WIKIPATHWAYS_20260410%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 ACAT2 HMGCR PMVK MVD FDPS HINT1 PATHWAY%WIKIPATHWAYS_20260410%WP5523%HOMO SAPIENS HINT1 pathway NFATC2 MNAT1 CCNH CDK7 GTF2H2C_2 RUVBL1 KARS1 SH3RF1 HINT1 RUVBL2 CTNNB1 FOS ERCC2 MAPK9 GTF2H2 JUN GTF2H3 GTF2H5 USF2 NFKB1 TCF4 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260410%WP5382%HOMO SAPIENS TGFB Smad signaling WWTR1 SMAD2 SMAD4 POSTN SPARC TGFBR1 TGFBR2 YWHAG TGFBR3 CTGF KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260410%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 AHR TDO2 AADAT HAAO AFMID IDO2 TNF KLF5 KYNU FOXO1 IL1R2 EIF2AK1 EIF2AK4 KMO IFNB1 CDKN1A IFNG IDO1 HEL-S-90n AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260410%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 OSTM1 SNX10 TCIRG1 RAB7A TNFSF11 TNFRSF11A IKBKB PLEKHM1 NFKB1 TRAF6 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260410%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 IL1A AGTR2 SERPING1 ROCK1 ACE2 AGTR1 TNF BDKRB2 NR1i1 ARHA BDKRB1 REN KNG1 CYP24A1 MAPK1 IL1B KLNA1 KLKB1 CPN1 NFKB1 CYP3A4 PRKG1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MMP2 TNFSF6 EGFR MCL1 ATF2 BCL2 FAS HBEGF BMF BAK1 MAP3K5 BCL2L11 FOS CDKN2A MAP2K6 IL6 MAP2K3 MAP2K4 CCNE1 BAX JUN BCL2L1 NFE2L2 TRAF5 MAPK14 TNFRSF1A TNFSF10 MAPK12 FGF7 RB1 IL2 TNF PDGFRA CCND1 JUNB MAPK8 MAPK11 TRAF2 CDKN1A CCNA2 IFNG MAPK13 TRAF6 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260410%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDK6 EZH2 RBBP4 ARID1A CDK4 SUZ12 CDKN2A SMARCC2 SMARCE1 RB1 SMARCD1 DPF1 DPF3 SMARCC1 SMO SMARCD2 EED SMARCD3 ACTL6B PTCH1 ACTL6A GLI4 ARID1B GLI3 DPF2 SMARCA4 H3F3B EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260410%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A IL1B NLRP3 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC42 CDC27 ARHA TUBA2 STAT3 RAC1 AMER3 STMN2 MZT2A FAM168B CCDC74A POTEE GPR148 ARHGEF4 APC CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias CYP51A1 DHCR24 EBP SC5D DHCR7 LBR 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5408%HOMO SAPIENS 15q25 copy number variation BNC1 SHANK1 TENT4B SYNJ1 BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB HOMER2 SPCS1 AP3B2 SPCS2 ALPK3 ZSCAN2 PDE8A SHANK3 EGF RYR1 WDR73 AP3D1 RNMT RAF1 SH3GL3 RYR2 DNM3 SPCS3 NMBR HTT AGAP2 TM6SF1 RAMAC ZNF592 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway DOK1 CRK ATF2 PIK3R1 BCL2 SPAG1 CBL ARAF INPP5D NRAS EIF4B MAPK1 HRAS MAPK3 MAP3K2 SHC4 SHC2 SHC3 BRAF MAPK14 HSPB2-C11orf52 PIK3CA GRB2 RPS6KA1 BCR KRAS SOS1 RAF1 AKT3 BCL9 MAPK11 CRKL SRC MEF2C PXN BCLAF1 HEL-S-102 GAB2 VAV1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260410%WP2855%HOMO SAPIENS Dopaminergic neurogenesis SOX2 PITX3 STAT3 EN2 LMX1A NKX6-1 LMX1B NEUROD1 SLC6A3 MSX1 NKX2-2 NEUROG2 OTX2 TGFB1 FOXA2 HEL-S-53e FGF8 SHH CDKN1C SLC18A2 WNT1 GBX2 EN1 ASCL1 DDC TH RET CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260410%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide TGFB1 CTLA4 CD80 FAS IL12A IFNG IL2 IL10 IL4 IL5 VIP OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260410%WP623%HOMO SAPIENS Oxidative phosphorylation ATP5PB ATP5F1D ATP5F1E ATP5PO NDUFB9 NDUFC2 ND3 NDUFC1 NDUFS6 ATP5J NDUFS5 ATP5H NDUFS4 NDUFS3 ATP5MG ND1 ATP5MF NDUFS1 ATP5ME DMAC2L ND2 ND5 ND4 ATP6AP2 ND6 NDUFB8 NDUFB7 NDUFA11 NDUFB10 NDUFB6 NDUFB5 COXFA4L2 NDUFB4 NDUFB2 NDUFB1 COXFA4 NDUFV3 NDUFV2 NDUFA7 NDUFA6 NDUFA3 NDUFA2 ND4L ATP5G1 NDUFA9 HEL-S-271 NDUFA5 NDUFAB1 NDUFS8 ATP6 ATP5MC2 ATP5MC3 NDUFA10 HEL-S-123m INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260410%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL1A TLR4 SMAD2 STAT4 IL5 STAT1 IF2B1 IL13 IL23R IL18RAP STAT3 RORC IL6 IL-21 JUN TBX21 IL21R NFKB1 RORA GATA3 TGFB1 IL17F NFATC1 NOD2 FOXP3 HLA-DMA MAF IL2RG IL2 TNF IL4 IL18 IFNGR1 IL12A IFNG IL10 IL23A IL12RB1 TLR5 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260410%WP3930%HOMO SAPIENS EDA signaling in hair follicle development EDAR BMP1 EDARADD TNLG7C SOSTDC1 DKK1 RELB SHH DKK4 WNT3 PTCH1 LTB ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260410%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL ABAT ASPA GOT2 ASS1 GAD2 GPT AGXT GAD1 PC 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5380%HOMO SAPIENS 5q35 copy number variation ADAM10 GPRIN1 MYC PIK3R1 BARD1 KDM6B RGS14 FBXW7 INPP5D HK3 FGFR4 PLCG1 PRR7 KIAA1191 FAF2 NELFB DDX41 TRIAP1 BABAM1 CAPN3 BABAM2 TMED9 RNF44 UNC5A MYO7B ARFGAP2 HIC2 IGF1R DOK3 CDHR2 TMED10 FAM193B DBN1 MAGED1 LMAN2 RAB24 ZNF346 SNCB GNAI3 PRELID1 PTPRN2 GNAI1 NOP16 EED MAPK8 MUPCDH ARL10 HIGD2A TSPAN17 ANKS4B MXD3 FGF8A FRS2 PDLIM7 CLTB GRIN2B PFN3 NTN1 EIF4E1B ABHD5 H2AX RNP24 COX6A1 SLC34A1 PNPLA2 COX6B1 HEL-S-273 UIMC1 CYP7A1 JUN GRIN1 USH1C COX7A1 COX3 ABRAXAS1 COX7B BRCC3 MAPK10 COX4I1 COX7C SNCA GRB2 PTH BRCA1 COX8A SOS1 COX5A DRD2 SRC MAX MAPK9 CXCR4 H3F3B COX2 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260410%WP4630%HOMO SAPIENS Measles virus infection CDK6 BBC3 ADAR IFIH1 BAD MAVS OAS1 RIGI CDK4 PIK3R3 HEL-S-72p PIK3CA CCND3 TP73 NFKBIB MX1 IKBKB IKBKG FOS CD3G CD3E IL6 CD3D CCNE1 JUN CDK2 MAPK10 IF1AA9 PIK3CD EIF2AK4 JAK1 IL1B IFNAR2 CD209 TYK2 RAB9A HEL70 IRF9 IFNAR1 PIK3R2 PIK3R1 IFNA13 CD46 IFNA14 IFNA16 IFNA17 CLEC4M EIF2AK2 OAS2 FCGR2B IFNA10 STAT1 STAT2 STAT3 IFNA21 NFKB2 IFNA1 IL2RG TRADD CCND1 CASP9 TNFAIP3 MAPK8 IL2RA IL2RB CASP8 TBK1 LNIR IRAK1 CASP3 IKBKE RCHY1 CHUK RAB9B IL12B IFNB1 IL12A FADD MAP3K7 IRAK4 NFKBIA TLR9 IRF3 EIF2S1 APAF1 TRAF3 TLR7 TRAF6 IRF7 IL1A TLR4 TNFSF6 MYD88 BCL2 HSPA2 IFNA4 FAS CYCS IFNA7 IFNA6 CCND2 IFNA2 IFNA8 BAK1 CSNK2A1 CSNK2A3 CSNK2A2 EIF3S3 BAX BCL2L1 NFKB1 CSNK2B CCNE2 IL2 CDKN1B JAK3 EIF2AK1 RELA MAPK9 STAT5B HEL-S-103 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome ESPL1 PTTG1 PLK1 CDC2 STAG2 SMC1B PTPA WAPAL RAD21 PDS5B PDS5A PPP2R1B SMC3 PPP2R5C SMC1A NIPBL AURKB PPP2R5E REC8 HDAC8 PPP2R5B PPP2R1A PPP2R5A CDCA5 SGOL1 ESCO1 ESCO2 PPP2R5D MAU2 STAG3 PPP2CA APC AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260410%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260410%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development L1CAM ATF4 SCN2A KCNQ2 SNAP25 CSNK2A1 CSNK2A2 SEMA3A SCN5A SPTAN1 DDIT3 SPTBN4 BRSK1 PRRT2 ANK2 CSNK2B EIF2A NUCLEAR RECEPTORS%WIKIPATHWAYS_20260410%WP170%HOMO SAPIENS Nuclear receptors NR0B1 NR2A1 NR5A2 NR1I3 NR1B3 NR1i1 NR2F1 NR1i2 RORC NR1H3 NR1C1 RXRB RXRA RXRG NR1H2 NR1D2 RORA ROR1 NR3A2 NR3C1 ESRRA NR2F2 PPARG NR2F6 RARA NR1C2 NR5A1 PGR THRA RARB NR2C2 NR1A2 NR2E1 ESRRB CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SHANK1 CASK HES5 HOMER3 PECAM1 AQP4 SOX2 LMX1B TPH1 GAD2 S100B SLC6A2 SLC6A3 NGFR FEV SYP SNAP25 NEF3 CNP CSPG4 NEFL BMP4 FGF7A 5HT1A CACNG2 SNAI1 ROBO1 MAP2 HOMER1 OLIG2 DPPA3 ZFP42 MBP DLG4 SHANK3 MOG SLC6A5 TPM1 GATA6 CDH2 CD34 GLS LHX1 NOTCH1 LEF1 NODAL NR2A1 AP2A1 TWIST2 PAX3 PAX6 MSX2 GAD1 HOMER2 ADRA2C HTR5A ADRA2B ADRA2A ITGB1 FOXD3 MSX1 MIXL1 FOXA2 SOX10 CLDN11 AP2A2 DLG2 NLGN1 PIG59 SLC1A2 SLC1A3 UNC13A ITGA6 TH POU5F1 GRIN2B DCX GFAP ESRRB RIMS2 SLC6A9 BSN RBFOX3 FBXO15 ACHE TBR1 LIN7A FUT4 CD24 SOX17 PCLO ERC1 DPPA2 ERAS GLRA1 GLRA2 GLRA3 GLRB TWIST1 RIMBP2 SLC17A6 SLC17A7 SNAI2 GRIN1 SLC6A1 GABBR1 SLC18A3 KLF4 GATA4 TBXT SOX9 ChAT HES3 GPHN TNC GABBR2 HES1 KCNJ6 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260410%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 HBG2 MTA2 HDAC1 HBG1 HBB GATAD2B HBE1 HBD PPARGC1A KLF1 tal-1 LDB1 MYB KDM1A BCL11A LMO2 ZFPM1 ZBTB7A GATA1 NR2C2 CHD3 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling MCL1 SLC2A3 PTGS2 BAK1 EDN1 NOS2 ANGPT2 ANGPT1 IGFBP2 BNIP3 BAX BCL2L1 BIRC5 PFKL EPO BCL2A1 PMAIP1 IGFBP1 HEL-S-30 HEL-S-133P HIF1AN BNIP3L HIF1A TGFA PDHA1 HEL-S-68p EGLN1 VEGFA CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP3869%HOMO SAPIENS Cannabinoid receptor signaling AHR DAGLA CNR1 ADCY1 CYP2C9 CYP2C19 CYP1A1 PRKACG MAPK1 PRKAR1B PRKAR1A CNR2 MAPK3 NAPEPLD DAGLB ADORA2A MAPK14 MAPK12 MAPK10 MAPK8 MAPK11 FAAH MAPK9 MAPK13 CYP3A4 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260410%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response IL1A CXCL8 TNF ITGA4 KNG1 VCAM1 SELP SELPLG IL6 C6 C7 ITGB1 HEL-S-62p LUNG FIBROSIS%WIKIPATHWAYS_20260410%WP3624%HOMO SAPIENS Lung fibrosis MMP2 ATP11A MMP9 CALCA IL5 PTX3 SFTPA1 CEBPB TERT TGFB1 BMP7 IGF1 TNF TIMP1 PDGFA SKIL SFTPC IL12B HGF TGFA CXCL2 CCR3 CCR2 CCL11 CXCL8 CMA1 CCL5 CCL4 CCL2 HMOX1 EDN1 IL13 CCL3 EGF IL6 FAM13A ELMOD2 GREM1 RTEL1 DPP9 FGF2 STN1 NFE2L2 SERPINA1 MUC5B CTGF CSF3 CSF2 FGF7 MT2A IL4 SPP1 KPG_011 IL1B SFTPA2 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260410%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients NEDD4 SMAD2 TGFBR1 TGFBR2 ATG16L1 TMEPAI ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP1541%HOMO SAPIENS Energy metabolism PRKAA2 CAMK2G ATF2 EP300 NRF1 FOXO1 PPP3CC MED1 NCOA1 MEF2D PRKAA1 UCP2 FOXO3A NR1C1 PRKAB2 SIRT1 UCP3 PRKAB1 RXRA PPP3CA PPP3R1 TFAM MAPK14 HDAC1 ESRRA SIRT3 PPARG GSK3B PPARGC1A TFB2M TFB1M PPARGC1B PRKAG1 NR1C2 PPRC1 PRKAG2 CAMK4 PRKAG3 MEF2C GABPA PRMT1 MEF2B PPP3R2 MYBBP1A CREB1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260410%WP167%HOMO SAPIENS Eicosanoid synthesis PLA2G5 PLA2G6 PTGES PRXL2B ALOX5 PTGS2 ALOX15 ALOX15B ALOX12 LTC4S ALOX5AP PLA2G4B PTGIS PTGS1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260410%WP51%HOMO SAPIENS Regulation of actin cytoskeleton ACTN1 PIK3C2G PIK3C2A CHRM2 STM7 PIK3C2B NCKAP1 PIP4K2A PIP5K1A PIP4K2B PIP5K1C PIK3R3 PIK3R5 PIK3CA ARPC5 DOCK1 GNG12 RASSF7 GNA13 FGF8A TMSB4X FGF7B PFN1 FGF7A FGF18 ROCK2 EGFR FGFR3 WAS FGF21 FGF6B PAK6 NRAS RRAS MAPK1 PAK4 BAIAP2 CSK ARHGEF7 MAPK3 FGF5C MAP2K1 FGF2 MAP2K2 BRAF MOS MYLK FGF7 KRAS FGF8 MYL1 SOS1 RAF1 MYL3 SOS2 PDGFRA PIK3CD RAC1 F2 IQGAP1 VAV1 HEL-S-15 FGF20 ARHGEF4 HEL70 FGF23 CHRM3 CRK CHRM1 FGF22 CHRM4 PIK3R4 CHRM5 EZR PIK3R2 PIK3R1 ROCK1 F2R FGF14 CDC42 ARHA FGFR4 FGF13 MAPK4 CFL2 FGF12 FGF10 FGFR1 FGF16 PDGFA ACTG1 PAK1 ITGA1 PS1TP5BP1 APC LIMK1 RAC3 APC2 ARHGEF1 EGF RDX RRAS2 WASF1 MYH10 MAPK6 SSH2 SSH3 SSH1 BRK1 PIP5KL1 FGD1 WASF2 ABI2 CD14 FGF9 BDKRB2 BDKRB1 CYFIP2 PXN FGFR2 HEL114 ARHGAP35 SLC25A46 PATHWAY%WIKIPATHWAYS_20260410%WP5521%HOMO SAPIENS SLC25A46 pathway APOOL MMGT1 IMMT TMEM85 COX4NB MICOS10 APOO MICOS13 CHCHD3 CHCHD6 EMC1 EMC2 EMC3 OPA1 EMC6 EMC7 MFN1 EMC10 MFN2 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260410%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PSEN2 CSNK1A1L APH1B VDAC3 PSENEN ATP2A1 DDIT3 ULK2 ULK1 PPIF PLCB4 PIK3CA SLC25A5 CACNA1F PLCB1 PLCB2 CACNA1S RTN4 KIF5A HEL-S-61 ATP2A2 TUBA1A PTGS2 IKBKB MAP3K5 NOS2 ERN1 APP IL6 RYR3 PPP3CA LRP5 LRP6 ATF4 CSF1 PSEN1 IL1B GPR83 BACE1 NAE1 MCU RB1CC1 WIPI1 CYBB TRAF2 ATG2A CHUK ADAM17 GRIN2B EIF2S1 APOE NOX4 CDK5R1 GRIN1 SHFM1 RELA MAPK9 BAD PPP3CC CHRNA7 PIK3R3 ITPR2 SLC25A4 PPP3R2 NRBF2 ATG2B IDE TUBA1C MME TUBB LPL TUBB2A KNS2 PSMA8 TUBA3E TUBB4B TUBB4A TUBB8 TUBB6 TUBB1 AMBRA1 ATG14 TUBA4A HSD17B10 RTN3 CACNA1C ARAF KLC4 NRAS KLC3 KLC2 TUBA2 TUBA8 MAPK1 SLC25A6 HRAS TUBAL3 BECN2 MAPK3 ADRM1 SLC25A31 MAP2K1 MAP2K2 BRAF MAPK10 CALM1 PLCB3 CDK5 KRAS RAF1 IRS1 PIK3CD HEL-S-162eP PSMD12 HEL-S-276 HEL-S-91n PIK3R4 PSMD13 PIK3R2 PIK3R1 PSMB6 AGER PSMD9 PSMD6 INS PSMD7 EIF2AK2 PSMB2 PSMD4 INSR PSMB3 PSMD2 PSMD3 PSMD1 MTOR PPP3R1 PSMC6 PSMA4 PSMC4 PSMA2 PSMC1 GSK3B TNF AKT3 CASP9 MAPK8 CALML6 CASP8 CALML3 CALML4 CASP3 FADD WNT3A AXIN1 DKK4 APAF1 APC IL1A WNT2B FZD10 FAS FRAT1 CYCS FRAT2 IRS4 TUBA1B APC2 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 XBP1 CSNK1E AXIN2 WNT16 DKK1 DKK2 SFRP4 NFKB1 CSNK2B TNFRSF1A SNCA ATG101 DVL1 WIPI2 DVL2 CASP12 DVL3 WNT1 WNT3 FZD1 CTNNB1 WNT10B WNT10A FZD3 FZD2 FZD5 CSNK1A1 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 IL26 SIGNALING%WIKIPATHWAYS_20260410%WP5347%HOMO SAPIENS IL26 signaling MMP9 IF2G MPO SMAD2 CXCL8 SOCS3 DEFB4B STAT1 MAPK1 STAT3 RORC EPHA3 MAPK3 ATP6V0D2 IL6 IL10RB BAX JUN DDIT3 IL33 CCL20 MAPK14 PIK3CA NFATC1 IL17A CSF2 CTSK ACTA2 DCSTAMP TNFSF11 TNF MAPK8 IL20RA CASP3 JAK1 IL1B RELA MAPK9 TYK2 IL10 NFKBIA COX2 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260410%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer NQO1 SQSTM1 TNFRSF21 YBX3 SOCS3 APOE ERBB3 F2R CTNNA1 GCLC MAPK1 HEL113 RNF7 ERN1 RPS6KB1 APP TNFRSF10B THBS1 PKN1 TRAF1 HEL-S-7 NFKB1 BIRC5 HDAC1 TNF CDKN1B HEL-S-89n NRG1 IL7R CUL5 HELLS BEX3 CDKN1A NET1 PTK2B AXIN1 CARD14 HEL-S-102 HSPD1 VAV3 JUND RIPK2 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260410%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GLS2 HEL-S-20 ARG1 ASL NAGS F10 ASS1 F7 GPT OTC EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260410%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria H3C15 HDAC2 MTA2 HDAC1 HEL25 MBD2 RB1 RBBP4 RBBP7 KDM1A SUV39H1 CHD4 MBD3 LEF1 MTA3 CBX3 CBX1 H3C8 H3F3B CHD3 DNA REPLICATION%WIKIPATHWAYS_20260410%WP466%HOMO SAPIENS DNA replication PRIM2 POLA2 RPA3 MCM3 RPA1 PCNA MCM5 MCM6 UBC ORC6 CDC6 ORC3 ORC2 DBF4 CDK2 MCM2 PRIM1 ORC1L CDC45 POLD3 POLD4 POLD2 POLE CDT1 POLA1 RFC3 RFC4 MCM7 RFC1 MCM10 RFC2 RPA4 GMNN POLE2 MAPK SIGNALING%WIKIPATHWAYS_20260410%WP382%HOMO SAPIENS MAPK signaling DUSP9 DUSP7 RAPGEF2 TAOK3 CACNB4 CACNA1G RASGRF2 DUSP16 PPM1B CACNG6 CACNG7 RPS6KA3 TAOK1 CACNG3 CACNG4 CACNG5 pk MAP3K8 DDIT3 HEL-S-72p CACNB1 CACNA1F CACNG1 CACNA1S FGF8A STK4 MAP4K1 MAP4K2 FGF7B CACNG8 MAPK13 FGF7A CACNG2 FGF18 FGFR3 ATF2 FGF6B NTF4 NTF3 IKBKB IKBKG MAP3K5 MAP4K3 FOS FGF5C PPP3CA FGF2 ATF4 FGF7 FGF8 MAP3K6 MEF2C IL1B MAX FGF20 MAPK8IP2 FGF23 MAP2K5 FGF22 BDNF DUSP4 DUSP2 FGF14 FGFR4 FGF13 FGF12 MAP3K11 PTPN5 FGF10 FGFR1 HEL-S-31 NFATC1 MAPKAPK5 IL1R2 CACNA2D1 TRAF2 NGF CHUK MAP3K7IP1 TRAF6 NFATC3 PPP5C HSPA2 MAPK7 NTRK1 NTRK2 EGF CD14 PRKCA RELA MAPK9 PLA2G4F JUND DUSP3 PLA2G4D PLA2G4E PLA2G4C MYC PPP3CC CDC25B PRKACG RASGRF1 GNG12 FLNA FLNB MAPK8IP1 PPP3R2 DUSP10 EGFR FGF21 CACNA1C ARAF NRAS NF1 RRAS MAPK1 HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 MAPK12 MAPK10 GRB2 KRAS SOS1 RAF1 LAMTOR3 SOS2 MAP3K12 CRKL RPS6KA4 RPS6KA5 RAC1 CACNB3 CACNA1B CACNA1A CRK RAP1A CDC42 RASA2 NFKB2 PPP3R1 FGF16 ECSIT TGFB1 IL1R1 MAP3K14 PDGFA TNF AKT3 ARRB2 MAPK8 PAK1 CACNA1I CASP3 MAP3K7 RELB HEL-S-102 TGFBR1 TGFBR2 IL1A TNFSF6 MAPKAPK3 GADD45A MAPKAPK2 FAS SMIM40 LRRK2 RAC3 TAOK2 MAP3K13 RRAS2 NFKB1 TNFRSF1A RASGRP4 NLK RASGRP3 MAPK11 FGF9 PLA2G4B FGFR2 CACNA1H CACNA2D3 CACNA2D2 CACNA2D4 HEL-S-103 MAPK8IP3 DUSP8 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260410%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G4B PLA2G5 PLA2G6 ACOX3 FADS1 ACSL3 FACL4 FADS2 ELOVL5 ACSL1 ELOVL2 ACOX1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260410%WP5314%HOMO SAPIENS Lactate shuttle in glial cells HEL-76 LDHB SLC4A4 CA4 SLC16A3 SLC1A2 SLC2A3 SLC16A7 HEL-S-133P NUDT14 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260410%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling TGIF2 SMAD2 FGF8 FOXG1 GLI3 NODAL SHH NKX2-1 TGIF1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260410%WP363%HOMO SAPIENS Wnt signaling NetPath CDK6 NFATC2 TCF3 STM7 FRAT1 CSNK1G1 ARHA MAPK1 TSC1 MTOR CSNK1E LRP5 ROR1 LRP6 GCKR ROR2 CTBP1 NLK PPARG PI4K2A GSK3B SOX1 DVL1 CCND1 DVL2 TSC2 DVL3 ARRB2 MAPK8 BCL9 PRKCB PRKCA CTNNB1 TCF7L2 RAC1 CSNK1D LEF1 MAPK9 MAP3K7 CSNK1A1 AXIN1 RYK GSK3A APC TCF4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260410%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260410%WP3958%HOMO SAPIENS GPR40 role in insulin secretion FFAR1 PLCB3 PLCL1 PLCD3 PLCE1 PLCB1 PKD1 PLCB2 PLCG1 PLCH1 GNA11 PLCG2 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260410%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition MTOR RPS6KB1 SLC2A4 RPS6 TBC1D4 IRS1 INSR ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP1B1 UGT1A10 CYP2C9 CYP2C8 HSD17B10 CYP2C19 CYP3A7 UGT1A8 HSD17B1 HSD17B2 SULT1E1 UGT2A2 HSD17B3 HSD17B4 UGT2B7 HSD17B7 CYP3A4 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260410%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 BDNF SNCA APP CEBPB SET AKT3 SRPK2 BACE1 TARDBP STAT1 ID SIGNALING%WIKIPATHWAYS_20260410%WP53%HOMO SAPIENS ID signaling RBL1 RB1 MYOD1 ID3 ID1 RBL2 ID2 PAX5 ELK3 PAX8 CCNE1 CDK2 PAX2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5049%HOMO SAPIENS Glycolysis in senescence PRKAA1 RB1 ENO1 HEL-S-68p HEL-S-162eP HEL-S-30 HEL-S-133P TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260410%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma PTEN GRB2 KRAS SOS1 RAF1 SOS2 TSC2 JAK3 AKT3 NRAS RPTOR STAT3 TSC1 EREG MTOR HRAS JAK1 EGF RHEB TYK2 BTC TGFA BREAST CANCER PATHWAY%WIKIPATHWAYS_20260410%WP4262%HOMO SAPIENS Breast cancer pathway CDK6 HES5 PTEN MYC CSNK1A1L CDK4 CETN3 SHC4 SHC2 SHC3 PIK3R3 PIK3CA IGF1R IGF1 FGF8A CDKN1A FGF7B FGF7A KIT FGF18 EGFR FGF21 FGF6B ARAF NRAS MAPK1 FOS HRAS MAPK3 FGF5C JUN MAP2K1 FGF2 MAP2K2 BRAF LRP5 LRP6 GRB2 FGF7 KRAS FGF8 TNFSF11 SOS1 RAF1 JAG2 SOS2 PIK3CD PGR HEY2 NOTCH1 DDB2 LEF1 FGF20 FGF23 FGF22 PIK3R2 PIK3R1 NOTCH2 NOTCH3 SP1 MTOR RPS6KB1 NFKB2 FGF10 FGFR1 FGF16 FLT4 RB1 E2F2 GSK3B E2F3 CCND1 AKT3 RAD51 WNT3A SKP1 AXIN1 PARP1 APC ERBB2 GADD45B GADD45A WNT2B GADD45G FZD10 FRAT1 FRAT2 BRCA2 NCOA1 BAK1 APC2 WNT5B CSNK2A1 CSNK2A3 ATR CSNK2A2 AXIN2 EGF WNT16 BAX RPS6KB2 SFRP4 CSNK2B NR3A2 RAD50 MRE11A ATM BRCA1 NBN DVL1 DVL2 DVL3 WNT1 FGF9 WNT3 FZD1 POLK CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 WNT4 CSNK1A1 WNT7B FZD7 FZD9 DLL3 DLL4 WNT7A FZD8 HES1 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260410%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer KSR1 MYC KRAS SOS1 RAF1 SOS2 FOS MAPK3 GAREM2 ALK JUN MAP2K1 MAP2K2 BRAF FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism HADHB NR1C1 ESRRA SLC2A4 ACADM MTTP APOB PPARGC1B ACLY STK11 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260410%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IL1A MYD88 MYC MAPKAPK2 ATF2 IKBKB EIF4E MAPK1 MAP3K8 MBP FOS MAP2K6 SAFB MAPK3 MAP2K3 MAP2K4 MAP2K1 MAP3K1 MAP2K2 NFKB1 MAPK14 IRAK2 MAPK10 IL1R1 MAP3K14 TAB3 MAPK8 MAPK11 NFKBIB RPS6KA5 IRAK1 CHUK RELA MAPK9 MAP3K7 IRAK4 NFKBIA MAP3K7IP1 TRAF6 TANK IRF7 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260410%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 MR1 TNFRSF11A TLR3 IFIH1 MAVS TLR8 IRF3 RIGI TLR7 IRF7 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260410%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence ELAVL1 SIRT5 SIRT2 GOT2 SIRT3 HEL-S-32 PRKAA1 HMGA1 NAMPT SIRT1 IL1B SLC2A4 RELA IL6 MDH2 NMNAT2 PARP1 CCL27 G13 SIGNALING%WIKIPATHWAYS_20260410%WP524%HOMO SAPIENS G13 signaling ROCK2 WAS PIK3R2 ROCK1 CDC42 LIMK1 ARHA PIP4K2A ARHGEF1 CFL2 RPS6KB1 RTKN RHPN2 MYBPH PKN1 CYFIP1 PIK3CA HEL-S-80p MAPK10 CALM1 MYL1 ARHGDIG PIK3CD SH3RF1 GNA13 WASL RAC1 ARHGDIB IQGAP1 HEL-S-15 CIT PFN1 TNK2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260410%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES7 EPHA4 RIPPLY2 TBX6 FGF8 NOTCH1 WNT3A MESP2 LFNG HES1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A CCL5 FYN KAT2B FAN1 MTMR10 GOLGA8R CHRNA7 FANCD2 ARHGAP11B GRM6 KLF13 GPR75 OTUD7A GOLGA8O CREBBP GOLGA8Q TRPM1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260410%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways HEL-S-14 CAMK2G HEL2 CRHR1 PLCG2 PRKAR1B PRKAR1A ADCY9 PLCG1 ADM ATF6B ITPR2 GRK5 GRK4 CRCP RXFP2 IGFBP4 CNN2 CALD1 GNG12 IGFBP6 GNG11 PDE4D GNG13 RAMP2 RYR2 RAMP3 GNB2 CORIN IGFBP1 GNB4 ADCY3 GUCA2B GNB3 GUCA2A GNB5 ACKR5 GNG2 YWHAZ GNGT1 GABPA GNB1 GNAS PRKD1 ATP2A2 YWHAQ ATF2 ADCY1 ADCY8 ADCY6 GNG3 GNG5 GNG4 GNG7 GNG8 FOS IL6 RYR3 JUN MAFF RYR1 CALM1 PLCB3 ATF4 ACTA2 MYL4 MYL2 GABPB1 SLC8A1 RGS4 GJA1 RGS5 RGS1 IL1B CREB3 RGS6 RGS7 CACNB3 CREB1 PKIB PKIA PKIG CALCA PRKCZ RGS18 IGFBP5 RGS17 RGS14 RGS16 RGS20 SP1 DGKZ RGS11 PDE4B RGS10 ATF5 OXTR HEL-S-1 ACTG1 OXT ARRB2 RGS2 PS1TP5BP1 PRKCQ CRH RAMP1 LPAR1 ACTA1 SFN YWHAG ACKR3 IGFBP2 NFKB1 ETS2 ATF3 PRKCH PRKCB PRKCE PRKCA HEL-S-21 MYLK2 CAMK2D CAMK2A RLN1 ATF1 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260410%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL3 FADS2 ELOVL5 ACSL1 ELOVL2 ELOVL1 SCD5 ELOVL6 FADS1 SCD FACL4 FASN OXYTOCIN SIGNALING%WIKIPATHWAYS_20260410%WP2889%HOMO SAPIENS Oxytocin signaling OXTR COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2881%HOMO SAPIENS Estrogen receptor pathway GPAM SP1 PDK4 STAT3 CYP1B1 NR1C1 JUN NR0B2 PCK1 ACOX1 CYP1A1 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260410%WP5461%HOMO SAPIENS Primary ovarian insufficiency BLM ATG9A MST1R PPM1B FANCM FANCL MSH4 STRA8 FMR1 DAZL CENPE POLR3H PRORP ANTXR1 MEIOSIN POF1B FANCC MEIOB MCM9 SIL1 NANOS3 GNAS PREPL EIF2B5 NOBOX AARS2 AIRE HMMR WDR62 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 HROB LHX8 MCMDC2 ELAVL2 BMPR2 C1orf146 MRPS22 SIX6OS1 HAX1 ZAR1 CCDC185 MGME1 C10orf2 MND1 NLRP11 XPNPEP2 SPATA33 CLPP POLR2C LARS2 POLG BMP6 FIGLA DMC1 PCCA PCCB ERAL1 BNC1 NOTCH2 HSD17B1 KHDRBS1 HSD17B4 CYP17A1 TP63 LAMC1 PRDM1 DCAF17 RAD51 BMP15 WRN GDF9 FSHR LMNA STAG3 TGFBR3 BRCA2 ZP3 STAR EIF4ENIF1 NR3A2 SLX4 RECQL4 AMHR2 ATM PGRMC1 NBN EIF2B1 FANCA FOXL2 ALOX12 NR5A1 SALL4 RFWD3 NUP107 WT1 SOX8 AMH PSMC3IP EIF2B2 BMPR1A EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP581%HOMO SAPIENS EPO receptor signaling GRB2 EPOR SOS1 EPO RAF1 SOCS1 IRS1 STAT1 STAT3 MAPK1 SRC PTPRC MAPK3 PTPRU CISH MAP2K1 STAT5B MAP2K2 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260410%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ACTN1 CACNB4 CACNG6 CACNG7 CACNG3 CACNG4 CACNG5 DSC2 ITGB5 ITGB1 SGCA ITGB4 ITGB8 PKP2 ITGB7 CACNB1 ITGB6 ITGA7 CACNA1F CACNG1 CACNA1S RYR2 ACTG1 ITGAV ITGA4 ITGA2 ITGA1 PS1TP5BP1 CACNA2D1 LMNA ITGA6 ATP2A2 CACNG8 CACNG2 SGCD SGCB CTNNA1 SGCG CACNA1C CTNNA3 CTNNA2 EMD DMD ACTN2 ACTN4 ITGB3 CDH2 ITGA2B JUP SLC8A1 tmp_locus_29 GJA1 DAG1 CTNNB1 TCF7L2 TCF7L1 LEF1 CACNB3 CACNA2D3 DSG2 CACNA2D2 CACNA2D4 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer MMP9 CXCL8 CCL5 CXCL12 CCL2 IL5 REG4 IL13 LGALS9 IL25 VEGFB IL6 VEGFC VEGFD CCL20 CCL28 CXCL1 TGFB1 IL17F IL17A CSF2 IL17D CXCL5 IL17C IL17B IL2 TNF IL4 IL1B IL12B IL12A IFNG IL10 IL23A VEGFA IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260410%WP5172%HOMO SAPIENS Iron metabolism disorders TF STEAP3 TFRC SLC40A1 FTH1 PANK2 SLC11A2 HAMP CP FTL UQCRFS1 CYBRD1 HFE2 HEPH TFR2 HFE HIPPO YAP SIGNALING%WIKIPATHWAYS_20260410%WP4537%HOMO SAPIENS Hippo YAP signaling STK38L WWTR1 YAP1 RASSF1 NF2 MAP4K3 TNIK LATS1 TEAD2 LATS2 TEAD3 TEAD4 MAP4K1 MAP4K2 MINK1 HEL-S-31 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260410%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis CPLX1 RPH3A RIMS1 SYT1 SYP SNAP25 STX1B NAPA UNC13A STXBP1 VAMP2 STXBP5 STXBP6 CACNA1B GDI1 CACNA1A GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA1 SIAT4C NEU3 B3GALT4 ST8SIA5 ST3GAL1 NEU4 ST8SIA6 B4GALNT1 HEXB ST3GAL5 HEXA ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260410%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK2 ATF2 PPP5C RNF168 CHEK1 IKBKG ATR TRIM28 MTOR CDK2 ATMIN RIF1 NFKB1 CEP63 STK11 MAPK14 MDC1 RNF8 MAPK12 RAD50 PPM1D CDK5 MRE11A ATM RBBP8 NBN PRKDC TP53BP1 SMC1A HMGN1 LMNB2 TSC2 MAPK11 AURKB NHEJ1 KAT5 HEL-S-102 PPP2CA MAPK13 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades PLG SERPING1 MASP1 CD46 F2R HEL-S-78p C1S CFH C1R CFI KNG1 F9 PROC F10 PROS1 F13B C4B_2 VWF C1QB C1QA THBD C1QC CLTC CR2 LMAN1 CFD C2 PLAUR CD55 SERPINA1 CPB2 SERPINC1 TFPI APOA2 PLAT BDKRB1 SERPINF2 F2 F3 F5 F7 C6 F8 C7 HEL-S-62p CLU C9 KLKB1 C8G C5AR1 C3AR1 MASP2 CR1 SERPIND1 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260410%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling TGFB1 SMAD2 BMPR2 MAPK8 LOX BMP1 SMAD4 MAPK9 GREM1 TGFBR1 TGFBR2 LOXL2 MAPK14 LOXL1 LOXL4 BMPR1A CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260410%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC3 UGT1A3 ABCC2 ABCB1 UGT1A1 UGT1A10 UGT1A9 CYP2C8 SLCO1B1 UGT1A8 UGT2B4 UGT2B7 CYP3A4 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260410%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX11 COX10 COX6A1 COX6B1 COXFA4 COX7A2 COX3 COX17 COX19 COX7B COX16 COX18 COX4I1 TACO1 COX7C HIGD1A COX14 COA6 COX8A CSRP2BP PET100 FAM36A CMC1 COX5A TMEM177 PNKD SMIM20 COA3 SURF1 COX2 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260410%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways PTEN FGF8A HNF1A ACTR2 FGF7B BMP4 FGF7A FGF18 EGFR FGFR3 FGF21 FGF6B BMPR2 ARAF MAPK1 FOS HRAS MAP2K6 FGF5C MAP2K3 JUN MAP2K1 MDM2 FGF2 MAP2K2 BRAF LRP5 MAPK12 LRP6 GRB2 FGF7 FGF8 SOS1 RAF1 PDGFRA FZD4 PIK3CD JAK1 WNT9B SELENOP FGF20 FGF23 MAP2K5 FGF22 ACVR1 SMAD6 PIK3R2 FGF14 ACVR2B FGFR4 FGF13 MAPK4 STAT3 FGF12 PTPN11 MTOR SMAD1 FGF10 FGFR1 FGF16 SMAD9 DKFZp781O1323 GSK3B PDGFA AKT3 SMAD4 WNT3A AXIN1 LIF APC WNT2B MAPK7 ERAS WNT5B EGF WNT16 MAPK6 NOG DVL1 DVL2 DVL3 WNT1 FGF9 WNT3 FZD1 CTNNB1 WNT10B IL6ST WNT10A FZD3 FZD2 FZD5 FGFR2 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 BMPR1A MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260410%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260410%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH3A2 ALDH2 ACO2 ALDH9A1 ACSS2 CS 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5400%HOMO SAPIENS 6q16 copy number variation LEP BDNF NPY INS INSR POMC SIM1 NTRK2 MC4R GHSR AgRP GHRL LEPR 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5407%HOMO SAPIENS 15q11q13 copy number variation MLSN2 SLF2 CGN CXNO FAN1 GOLGA8R CHRNA7 KLF13 OTUD7A GOLGA8O GOLGA8Q TRPM1 GOLGA8H HDAC1 CANX STX1B ANKRD2 SIN3A TJP1 CCL5 APP FANCD2 CREBBP CDC42BPB CALM1 CXADR TJP3 GJA1 SPEF1 SMC5 KAT2B SMC6 STX1A ANKRD32 GOLGA8T MTMR10 NSMCE3 NSMCE2 RELA NSMCE1 GOLGA8K STXBP1 GOLGA8J GJD3 MYZAP NECAB3 LYPD6 ENTREP2 UBN1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260410%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS BMP2 OLIG1 OLIG2 MBP MOG FGF2 NKX2-2 CXCL1 SOX10 SOX6 IGF1 TNF SOX5 SHH OMG CNTF SOX8 SOX9 IL1B CNP ASCL1 CXCL2 LIF NKX2-6 MYT1 BMP4 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260410%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 PRL KLF2 CXCL12 RGS16 MYB OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260410%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy VHL ACAN COL2A1 CNMD P4HTM FGFR3 GANC FOSB NTRK1 FGFR4 KDR MAPK1 STAT3 FOS COL1A1 MAPK3 COL3A1 FGFR1 CEBPB JUN RUNX2 NFKB1 CTGF PIK3CA IBSP COL10A1 SPP1 LAMTOR1 DDR2 AKT3 JUNB PRKCA SOX9 NGF HIF1A RELA FGFR2 RELB JUND VEGFA FGF23 FOSL2 FOSL1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260410%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 ROBO2 SOX17 ROBO1 SOX11 IFT27 SPRY1 GREM1 FAT4 SLIT2 PAX2 GATA3 IFT25 FOXC2 WT1 HOXD11 CTNNB1 HOXA11 SALL1 LHX1 GLI3 SIX2 GDNF ALDH1A2 EYA1 TCF2 FOXC1 HOXC11 RET BMP4 RAS SIGNALING%WIKIPATHWAYS_20260410%WP4223%HOMO SAPIENS Ras signaling PLA2G4C PLA2G3 PLA2G5 PLA2G6 PLA2G10 RASGRF2 BAD RASSF1 PLCG2 PRKACG KDR PLCE1 TIAM1 PLCG1 RAPGEF5 SHC4 SHC2 SHC3 RASGRF1 PIK3R3 EPHA2 GNG10 PIK3CA IGF1R RAB5C NGFR GNG12 GNG11 GNG13 GNB2 GNB4 GNB3 GNB5 GNG2 GNGT1 STK4 GNGT2 GNB1 KSR2 KIT EGFR FGFR3 PLA2G2A GNG3 IKBKB GNG5 PAK6 SYNGAP1 IKBKG GNG4 NF1 NRAS RRAS GNG7 MAPK1 GNG8 PAK4 EXOC2 ABL2 HRAS MAPK3 MAP2K1 MAP2K2 SHOC2 MAPK10 CALM1 RASA3 GRB2 RAB5B KRAS SOS1 RAF1 SOS2 PDGFRA PIK3CD RAC1 RIN1 CSF1R GAB2 ZAP70 RAB5A PIK3R2 PIK3R1 RASAL1 FOXO4 RASAL3 TTBK1 RAP1A RASA4B PLAAT3 CDC42 RASA4 ARF6 INSR PLA2G2F PLA2G2E PLA2G2C ARHA FGFR4 RASA2 PTPN11 REL FGFR1 FLT1 FLT3 FLT4 AKT3 MAPK8 PAK1 CALML6 CALML3 CALML4 CHUK LAT GRIN2B PLA1A KSR1 TNFSF6 MET AFDN RAC3 NTRK1 NTRK2 GRIN1 HTR7 BCL2L1 NFKB1 RRAS2 ETS2 RALBP1 RASGRP4 PLD2 RASGRP3 PRKCB PRKCA PLA2G4B RELA FGFR2 MAPK9 RALA PLA2G2D PLA2G12A RALB PLA2G4F PLA2G12B PLA2G4D PLA2G1B PLA2G4E CORI CYCLE%WIKIPATHWAYS_20260410%WP1946%HOMO SAPIENS Cori cycle SLC2A4 HEL-S-87p GPT INS PGAM1 HEL-S-68p HEL-S-162eP SLC2A2 HEL-S-49 HEL-S-133P PFKP DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP707%HOMO SAPIENS DNA damage response BBC3 CDK6 CHEK2 MYC TLK1 CDC2 CDK4 TNFRSF10B TP53AIP1 SESN1 CCND3 RB1 PRKDC CCNB2 CCND1 PML CASP9 RAD51 CASP8 CASP3 CDKN1A APAF1 RRM2B GADD45B GADD45A GADD45G FAS CYCS CCND2 SFN CHEK1 H2AX RAD1 ATRIP HUS1B ATR TLK2 RAD9A CCNB3 CCNE1 BAX FANCD2 CDK2 MDM2 RAD50 CCNE2 CDK5 MRE11A ATM BRCA1 NBN PMAIP1 SMC1A CDKN1B RAD52 RAD17 PIDD1 RFC1 CCNB1 DDB2 CREB1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260410%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CACNA1C CHRNB4 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260410%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment TNFSF6 FAS NRP1 CCL5 CXCL12 BAG3 CCL2 CXCR3 KDR CTLA4 HLA-DRA HLA-DRB1 ITGB6 IFITM2 TGFB1 CSF2 CSF2RA CSF1 CD80 CCR5 CSF1R CXCR4 CCR2 LAG3 VEGFA TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD6 SMAD2 INHBA STAT1 ADAMTSL2 RUNX3 pp6425 STAT3 SMAD1 ZFYVE9 BAMBI ITGB6 SMAD9 TGFB1 DKFZp781O1323 FKBP1A ZNF423 TNF SKIL SMAD4 TGFBR1 TGFBR2 LIF TGFBR3 BMP4 EP300 SKI LEFTY1 LEFTY2 FOS HRAS MAPK3 EGF THBS1 RUNX2 JUN FOXH1 NFKB1 CREBBP NOG FST SPP1 WNT1 TGIF1 CTNNB1 ZEB2 JAK1 IFNG LEF1 MAPK9 LTBP1 FBN1 ENG VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260410%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression CHRM1 ATP2B1 BCL2 KCNQ2 KDM6B CACNA1C GCLC CYP27B1 NR1i1 ATP2B3 KDM1B ATP2B2 CALB1 ATP2B4 TPH2 PVALB TPH1 RXRA GRIN1 ITPR2 NFE2L2 SLC8A1 KDM1A CYP27A1 KDM3A HEL-75 KCNQ3 GRIN2B WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260410%WP399%HOMO SAPIENS Wnt signaling and pluripotency MYC PRKCZ SOX2 ARHA FBXW2 PPM1J FOXD3 CCND3 PPP2R1B PPP2R5C GSK3B CCND1 PPP2R5E PPP2R1A PRKCQ WNT3A PPP2R3A MAP3K7 AXIN1 PPP2R2C PPP2R2B CTNND1 POU5F1 PRKD1 PPP2CA NFYA ESRRB APC ZBTB33 WNT2B EP300 CD44 FZD10 FRAT1 LRRK2 CCND2 LDLR WNT5B PAFAH1B1 CSNK1E AXIN2 WNT16 MAP2K4 JUN PTPA CREBBP LRP5 LRP6 MAPK10 CTBP2 CTBP1 NLK NKD1 NKD2 DVL1 DVL2 NR1C2 DVL3 FZD4 PRKCH WNT1 PPP2R2A PRKCB WNT3 PRKCE FZD1 PRKCA CTNNB1 WNT10B PPP2R3B PRKCI TCF7L2 WNT10A WNT9B FZD3 TCF7L1 FZD2 LEF1 MAPK9 FZD5 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 MMP7 FOSL1 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260410%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis SLC2A3 MPC2 FBP2 PGAM1 ALDOB HK3 ENO2 ENO3 GCK SLC2A4 HK2 MDH2 SLC2A2 PC G6PC1 PFKL GOT2 DLD HEL-S-32 MPC1 PCK1 HEL-S-30 HEL-S-133P FBP1 PFKP LDHB DLAT HEL-S-87p PKLR PGAM2 ENO1 PDHA1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260410%WP3407%HOMO SAPIENS FTO obesity variant mechanism UCP1 PRDM16 IRX3 PPARGC1A IRX5 TBX1 ARID5B