SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors 7341 7376 7068 5241 6256 7421 5465 8554 2099 7181 6095 367 4929 6612 2908 51588 9759 5468 7329 6613 4306 5914 10401 2516 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen 9562 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 1892 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA 5478 NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes 7157 1373 5009 383 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis 23659 57153 9791 23259 57678 84879 58488 150763 50640 50487 151056 10390 137964 9600 114884 80736 80339 1040 56910 117245 56994 10554 57605 10555 8904 54979 5130 8760 10162 114879 123745 171586 84895 114882 85465 2819 5920 8895 9468 26279 1460 10809 590 23446 126969 1459 201164 1457 81579 2820 55326 56894 57104 56895 51365 11343 6901 253558 158835 22925 200879 56261 63874 64600 57110 204962 27132 23171 1103 79887 248 23175 255189 254531 79888 283871 30814 10423 8398 8399 64850 5320 5321 9489 5322 255043 1120 9362 283748 80821 55500 114971 55224 5833 5319 1119 8443 64900 3032 3030 79143 55750 100137049 149998 122618 10400 54947 154141 9926 43 9663 374986 8694 129642 23760 23761 162466 23646 84803 84649 54675 347516 8605 51205 5337 11145 5338 81490 83394 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling 1950 5335 2064 1956 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition 6790 8454 9662 8655 7840 6233 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 84962 1454 1453 55125 5577 9814 7316 9738 10133 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 23291 1069 5500 5347 22919 54801 10142 7846 9702 10540 5108 4218 4659 11116 4751 5048 55142 22897 891 54930 8945 5116 79959 80184 5518 93323 7277 9133 7311 7314 6500 23354 22981 8481 80254 983 121441 55755 54820 10806 79866 10121 5566 55835 55559 8636 11258 84131 4957 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 596 27113 598 5366 6774 637 90427 572 10018 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix 5663 3914 1215 3915 3918 1299 1298 4323 5654 999 4324 4325 10893 4326 4327 6868 3911 3912 9510 7177 91522 92291 2 85007 9507 1509 1508 649 1504 6650 5045 1514 1634 1513 1511 80781 147968 3817 3818 26254 1991 23385 1515 10753 84290 7077 50859 7076 222663 440387 1520 170690 823 824 825 826 827 170692 84570 5340 440854 388743 831 836 7373 9313 136227 7093 7092 682 63827 1305 1303 960 726 4811 80274 1308 1307 1306 8751 6696 8754 176 3339 1310 56999 64386 11096 5650 11095 4320 11131 4321 164656 4322 1297 101 102 23473 3909 4312 5644 4313 11132 5645 4314 4316 4317 4318 4319 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression 5928 5929 79862 9968 57678 30834 9969 340252 902 10445 5925 10555 84962 9862 9188 6595 7562 4297 6597 285676 6599 6598 29947 51082 55683 6908 6907 57504 55689 8648 10891 5931 9739 404672 7695 7576 94239 22880 9070 729359 1107 123 23054 9869 51535 60481 65251 155054 1108 22976 7343 162967 25 5166 162963 29128 7581 10514 147686 54934 11168 9757 54815 91661 9533 6940 8202 54145 55596 284306 23272 11176 948 53615 58508 9422 8331 8337 8334 8335 1022 200424 1020 1810 51562 84246 26993 197320 5977 7913 10179 8341 8342 8347 8348 8345 8467 23378 29915 25799 8340 79685 84911 6839 79447 29115 1024 1387 80312 60 8338 605 9443 259282 8473 8110 9442 2494 25885 9440 23468 79595 57325 147646 84148 85236 6601 8349 6603 10155 9439 51105 6602 6605 6604 54737 22822 22823 10284 64425 125893 57693 64426 1050 7270 79101 2932 147658 51230 57459 80335 10849 7700 86 4331 6871 2033 26039 8370 51003 6256 2146 2145 79813 284058 8800 9219 10499 51129 55729 9477 6760 9112 162655 4221 7329 3013 6613 90390 221830 8819 23451 6996 8932 10025 255626 55617 5440 23309 5441 7069 3021 63924 91272 2966 892 2965 3018 3017 2167 3014 5434 5435 5437 10474 57104 79718 121536 2968 11343 2967 9014 2180 9015 8289 9013 90853 8841 474382 9370 26147 10919 57492 10001 11335 84172 23175 8970 8850 128312 2074 54790 25942 2071 81931 340602 55766 79611 2068 8726 8968 4023 23411 3054 26009 9274 9275 90075 9031 29079 1789 1788 1786 2874 5346 7767 7403 5469 3720 6319 133522 113835 23067 9282 8193 3066 3065 112869 653604 143689 55422 51742 84661 10793 2648 84649 11091 5252 23517 9612 30827 3991 9611 100170841 23512 8085 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides 245936 245937 245938 6278 245939 5266 5068 4057 6279 6037 613210 116842 613211 245930 728358 245932 245934 671 503841 641517 475 613209 55600 400830 5657 51248 10578 130120 729230 4069 1671 1670 1511 245940 6280 338324 7097 7096 1191 1991 55894 1668 57119 100133267 140683 140881 51297 920 57115 6556 6039 128859 1669 245913 8993 503618 503614 245911 122665 117285 80341 1235 114770 1113 114771 1673 140850 1672 538 417 6406 3934 5320 245927 245928 245929 81623 84659 3347 3346 820 149954 117159 644414 5646 92747 504180 5645 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis 4851 5687 5688 5689 6911 5700 5701 10683 5702 5704 5705 9861 5682 5683 5684 5685 5686 28514 5717 3516 5718 5719 1499 84667 11047 10213 5713 5714 7979 3955 343930 5690 5691 5692 134701 5693 5694 5695 2043 5706 5707 145873 5708 5709 51176 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism 56922 3141 31 51248 32 5095 64087 5096 686 8884 5091 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport 204962 57153 345274 60482 23446 126969 80736 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements 5687 5688 5689 5700 5701 5702 5704 5705 5580 11340 8570 9261 23404 3315 54512 3312 677 7514 5578 55802 5393 7534 8741 23016 8021 5073 51010 167227 1981 51013 207 6233 3842 7529 118460 22894 1994 1432 56915 7538 8125 26986 54464 3304 5600 6418 7316 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state 5687 5688 5689 5700 5701 5702 5704 5705 8454 6233 8650 7289 9742 5577 23322 55081 7316 111 112 113 114 115 55764 51684 1452 79659 9978 374654 8100 83737 80199 51098 55811 79809 26160 196883 6608 11127 57728 5573 5575 5576 23432 2735 2778 27152 9861 107 5682 108 5683 5567 5684 8945 109 5685 5568 5686 57539 54903 5717 2737 5727 5718 2736 5719 7311 7314 11047 6500 10213 5713 5714 8481 7979 5690 5691 5692 5693 5694 5566 5695 5706 5707 2932 5708 5709 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 55624 729920 1605 120071 2218 10329 10559 9486 79147 11041 9215 113829 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 5928 10919 57504 8341 11335 8342 8970 8347 8370 8348 128312 5931 8345 2074 94239 8340 9219 55766 1107 8968 9112 3013 8338 1108 255626 3021 85236 54815 8349 3018 3066 3017 54145 3065 3014 653604 53615 8331 8337 8334 8335 7270 474382 57459 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs 22821 153090 5687 5688 8437 5689 5921 5922 5700 5701 5702 5704 5705 6233 7316 9978 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 8452 5692 4893 9462 5693 4763 5694 64926 5695 84078 5706 8831 5707 3265 399473 5708 10156 5709 161742 200734 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation 1675 3004 629 718 HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle 6908 902 129685 6872 404672 22916 6874 6873 23327 2547 27243 55048 23165 4686 128866 89853 10015 6749 9631 7175 6881 6880 5430 6883 5431 6882 5432 8148 5433 6884 7852 6917 11168 79643 1104 51652 51497 11198 6875 6878 83860 6233 8812 6877 51534 2959 2958 6879 8815 2957 348995 920 9883 9525 57122 1022 2963 2962 2961 1234 2960 29082 7316 5436 55746 6921 5438 6924 137492 5439 6923 27183 91782 23279 25978 79023 51271 7469 138474 10762 8178 92421 6396 8732 7520 129401 8731 51160 6829 3836 4927 3159 7518 155382 6827 9397 93343 9150 7251 5905 79720 2237 1025 5901 5902 7311 51616 7314 5903 3981 9688 23225 25920 54457 51224 7936 55706 3978 23636 9972 11097 23511 8086 53371 8480 79902 51510 904 905 4836 4331 5478 7514 5440 5441 5045 8021 2966 2965 5434 5435 5437 2968 2967 2071 2068 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 1462 2990 23553 3373 8372 112937 3074 1634 3073 3425 79411 411 2720 63827 3423 633 89944 1463 10675 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes 7318 3309 3429 7706 9246 64135 22926 3551 23586 25820 51191 9451 2537 10964 1147 2289 8517 9636 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling 6456 1175 160 161 163 26052 4914 1785 1213 1211 1759 10126 4803 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade 5518 1452 1499 8312 23401 5519 324 10023 5525 5515 5526 5516 5527 2932 5528 139285 5529 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib 3320 2064 11140 55914 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 90550 91689 6687 5245 9512 10939 23203 55486 55013 79568 221154 11331 30968 10367 10730 286097 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development 7484 153572 6495 6299 130497 79192 6092 2296 7481 2625 6928 2668 10736 2303 652 57526 2247 3237 3214 3975 28514 5979 5076 9353 5455 2122 1499 182 54361 7490 3172 3207 255743 2018 3955 10406 3227 2138 3203 2674 3400 26585 8516 3688 51316 7849 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK 3718 29126 238 5777 6774 639 2033 5295 3091 5296 10818 5290 5291 25942 5764 4613 3667 5803 1786 5335 3066 3065 285016 3561 4192 8841 389658 4609 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat 5436 6921 4331 5438 6924 5439 6923 902 404672 22916 2071 7469 8178 2068 4686 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 2966 51497 2965 11198 8812 25920 5434 5435 51224 5437 7936 2968 2967 1022 2963 2962 904 905 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs 192669 23112 27327 26523 27161 192670 57690 1009 4343 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF 9759 2033 595 861 6046 864 865 7040 3845 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins 1544 1576 1565 1571 2053 240 1559 1558 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants 3320 2064 11140 55914 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 7341 79047 7329 7022 7021 83741 51741 339488 7020 284252 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX 27338 119504 10919 1051 246184 1029 3569 51434 51433 6934 79813 4343 192669 23112 27327 26523 192670 57690 595 7157 1499 7321 4790 25906 11065 8697 7324 10393 29945 29882 1436 996 27287 51343 51529 8881 64682 5970 51176 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection 5777 5925 7097 6233 7096 3320 7316 7532 7531 6230 6232 6231 6234 64398 6235 63982 253832 6227 6229 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 7335 64601 79760 6480 10427 256435 27090 9868 9641 11282 8678 5289 3661 7311 29801 7314 85437 81631 51304 3654 55107 3656 91662 6383 10082 6385 7113 59272 22863 5170 6382 143 58505 2697 51311 79668 821 3665 27072 3442 3441 3440 23367 114548 3439 2589 51201 54956 100128731 55129 10971 10610 221914 9672 3452 3451 2239 3449 3448 29110 3326 3446 3445 26762 3444 54960 3443 89122 10392 84818 3456 3454 55823 857 7534 5045 6607 8487 1514 6185 8021 6188 6187 6189 2262 23479 6184 207 23118 121601 7529 2931 2810 3107 3106 3105 6733 11253 746 54625 51114 6732 2817 5648 1603 5781 6632 7841 203859 6191 6193 6192 7284 6194 57101 1452 26276 51125 51128 65082 84282 6628 7297 23339 6885 338440 3134 3133 9908 6634 6633 2719 6636 6635 10146 3339 3921 6637 7187 7189 84061 6773 6772 80143 55741 79833 3135 11320 8829 7991 92359 340061 4245 4124 3276 11218 10802 56965 201595 10484 10000 3703 50628 2197 7082 23765 3716 140032 3838 1655 51284 1650 4247 4249 10454 50636 6441 6201 30849 6203 6202 7533 64127 26007 25834 567 83666 196527 84875 27243 79844 5589 23165 57719 208 128866 11311 375790 7405 3605 9631 6210 7175 112744 4153 25929 25921 51065 7415 6205 6204 6207 6206 6209 6208 6223 79643 6222 7555 51652 6224 257397 23193 10207 2530 7428 6218 6217 57617 348995 9883 57122 29082 55746 91782 23279 25978 79023 10762 92421 6396 1387 129401 4927 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 2932 79902 7341 64135 3551 23586 7329 1147 8517 9636 7706 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome 6908 4331 902 129685 6872 404672 22916 6874 6873 4686 6749 6881 6880 5430 6883 5431 6882 5432 8148 5440 5433 6884 5441 6917 2966 51497 11198 2965 6875 6878 83860 8812 6877 5434 5435 2959 5437 2958 6879 2957 2968 2967 1022 2963 2962 2961 2960 5436 6921 5438 6924 5439 6923 2071 7469 138474 8178 2068 8732 8731 6829 6827 9150 1025 51616 25920 54457 51224 7936 904 905 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels 808 487 488 489 6543 6546 6547 490 491 492 493 6717 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors 1135 1134 8973 1143 1142 1141 1138 1137 1136 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 2767 10238 59345 10517 6774 26330 898 1155 347733 84261 2769 9134 7278 22948 63971 26985 2782 26224 79861 81027 54461 2776 10528 5203 5204 10681 8877 10564 7157 1460 1459 1457 8841 908 113457 10383 6950 10382 7203 2793 2792 7280 2791 2790 26272 6905 2788 2787 2786 83752 7846 2785 2784 60 26234 2783 51764 10693 6468 10376 10574 10694 6902 10576 2629 10575 80086 26190 6904 26270 6903 7277 9630 94235 51807 6000 22803 8787 10381 7411 8786 55294 112714 55135 55970 402 9628 84790 10471 5201 5202 6499 5082 84617 11328 54331 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 5928 7700 79862 57504 340252 8370 5931 7695 7576 94239 9219 55729 1107 9112 9869 162655 3013 7329 65251 155054 6613 1108 162967 255626 162963 7581 147686 3021 54815 91661 6940 3018 3017 54145 3014 284306 53615 9422 8331 8337 8334 8335 474382 197320 8341 8342 8970 8347 8348 128312 8345 25799 81931 8340 55766 84911 8968 8338 90075 23468 7767 85236 113835 8349 10155 3066 3065 653604 55422 10793 125893 57693 7562 285676 147658 57459 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia 54657 DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG 2582 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies 3938 6476 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing 4851 2033 8370 94239 4343 192669 23112 27327 26523 27161 192670 57690 3013 595 861 5584 255626 100996717 7157 84441 9794 5870 6400 2683 5045 3021 55534 56983 4853 5986 4854 4855 3018 1869 3017 54145 3725 23509 3014 22938 1991 7027 1871 487 10959 488 51548 489 1999 8331 4242 8337 100996763 8334 388677 8335 7029 10046 10402 474382 8341 8342 8970 8347 8850 8348 128312 8345 8340 55766 8968 1387 8338 6484 6487 3516 85236 8349 653604 3955 2648 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 5607 5598 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) 283652 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 5921 6774 898 3091 2908 595 1950 2064 1956 207 6233 9542 2909 2034 7316 9021 3084 1019 10657 27043 10656 1017 2069 10457 5829 1027 685 120892 9564 9844 116985 63916 1796 1398 10718 1793 55620 5753 1839 5879 6725 5770 6421 202559 387 867 145957 7311 7314 4893 3265 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) 10055 6612 10054 7341 6613 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism 8034 51248 8875 8876 5167 5168 5169 2194 80025 284439 254552 80347 8884 53354 79877 79646 60496 79717 55229 60490 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion 948 2182 2181 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 55253 55039 57570 9836 127253 129450 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript 6431 9984 10250 22794 29107 57187 51362 199746 7919 84324 84248 22916 6427 84321 6426 9939 6429 10212 6428 23165 728343 4686 9877 51213 10189 84271 65109 9631 80145 7175 26097 8563 8683 9775 10482 9295 10569 10921 11338 2733 55110 79228 4116 7307 8021 348995 9883 57122 55746 23279 79023 10762 6396 129401 4927 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 9785 6430 6432 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD 215 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 140803 7220 7222 7442 7224 7223 7226 7225 59341 79054 55283 26133 54795 8989 55503 4308 162514 255231 57192 80036 56302 51393 57113 29850 54822 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation 7099 929 8772 7186 8795 8743 8797 353376 23643 148022 355 356 841 8737 8717 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation 10454 5687 5688 5689 5700 5701 5702 5704 5705 3551 1147 8517 257397 8454 6233 23118 7321 4790 5970 7316 23291 7322 6885 997 10892 4067 84433 5588 4792 10235 115727 10125 7334 8915 7335 9861 7189 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5170 5706 5707 5708 5709 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 5879 4915 1020 8851 627 7074 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization 3091 5753 1839 1956 10457 120892 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 2646 2645 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 84515 4172 4173 4174 4175 4176 64785 8318 9837 84296 4171 51659 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 7046 7040 7048 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation 673 4803 5906 5594 5595 1399 5604 5605 10818 2889 7529 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling 2247 10818 4893 6654 2254 8074 2249 3265 2246 10817 8823 5781 8817 26281 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters 10568 6569 142680 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly 341 5034 346 338 4547 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase 5687 5688 5689 5700 5701 9184 5702 991 5704 26271 5705 890 8900 4085 701 8454 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 1017 51433 5347 9861 5682 891 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E 7316 7311 7314 6233 METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism 9968 9969 51248 5646 9861 5682 5683 5684 5685 5686 5717 5718 5719 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 64087 5096 686 8884 5091 56922 3141 31 32 5095 9261 5578 8021 207 111 112 113 114 115 196883 5573 5575 5576 2778 107 108 5567 109 5568 11041 23165 9631 7175 348995 9883 57122 55746 23279 79023 10762 6396 129401 4927 9397 5901 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 4836 1462 2990 23553 3373 8372 112937 3074 3073 3425 79411 411 2720 3423 633 89944 1463 10675 1785 5519 5515 5516 5528 5295 5296 5290 5291 1558 1544 1576 1565 1571 2053 240 1559 6230 6232 6231 6234 6235 6227 6229 6228 6483 6482 9871 6484 6487 9632 10427 5289 6383 10082 6385 6382 143 79668 54956 221914 9672 2239 3326 857 6188 6187 6189 2262 54625 2817 6191 6193 6192 6194 51128 2719 3921 10802 56965 10484 2197 140032 6201 30849 6203 6202 26007 83666 84875 375790 6210 51065 6205 6204 6207 6206 6209 6208 6223 6222 6224 6218 6217 808 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 2629 9630 94235 55970 54331 2767 59345 26330 2769 2782 2776 10681 8877 54657 2582 2683 10402 8034 8875 8876 5167 5168 5169 2194 80025 284439 254552 80347 53354 79877 79646 60496 79717 55229 60490 2182 2181 215 2646 2645 5906 338 81849 81846 4969 27087 3638 170685 56898 1455 27089 121278 340485 3630 3631 3632 3633 3635 3636 4967 10654 340481 5827 2799 1468 55572 55576 9 140801 5825 5826 160428 2331 2328 55586 4507 2327 4508 55101 4509 27063 2326 57761 55588 27068 5831 5834 374291 5836 5837 10632 64064 134147 4520 1491 81857 4519 171546 4512 4513 4514 158584 64077 5860 2350 81889 2346 81894 4522 4524 5859 4540 285521 6720 4541 6718 6713 4534 64080 4535 5867 4536 6715 5868 4537 4538 6716 113675 4552 653689 8908 56474 1036 6721 6723 617 4548 376497 79581 79586 5409 10606 622 27034 5406 1066 23563 2395 3242 51121 635 79934 55967 55969 8942 23576 3251 339896 3248 644 645 5424 151531 11112 6770 4594 113235 5443 4597 5444 1081 51141 51144 55501 54659 54658 6783 4123 6785 6301 51151 660 10249 55512 79944 4598 5445 669 5446 5447 10243 9807 56848 10247 6794 5464 10690 23521 3284 3283 670 54677 51166 4125 4126 6303 55526 6305 4128 4129 57704 6307 6309 3291 5471 3290 4141 4143 4144 5476 23530 389396 123099 3295 23533 3294 3293 51171 3292 51170 683 10229 203 51179 204 79966 205 6799 5467 8976 54205 137682 10226 113278 51181 79993 10678 210 211 212 213 216 217 218 219 8503 8509 345275 6342 6341 4166 5498 5499 57733 221 222 51196 223 226 10682 229 5007 10201 326625 8534 79094 64834 230 231 116255 51520 83594 239 8528 11069 5018 5019 83592 8529 8540 23057 241 242 246 247 4199 9885 165679 116228 4190 4191 51540 55902 60495 11046 8564 5053 9415 9412 9896 8566 6389 130589 8560 262 51552 347527 8574 9420 270 6391 271 272 6390 23007 6392 275 117145 122961 84002 7252 161247 9435 23498 116285 23491 54600 51573 9429 55937 7263 9441 9446 291 64419 51582 51102 51586 11001 11000 51103 2806 2805 10157 51109 7274 646486 131870 9453 7276 153642 11010 23474 23475 5092 64428 26503 646480 128240 1962 10165 84498 51117 10166 9469 57226 2821 201562 79018 79017 84842 83990 7296 7299 134526 7298 7295 79001 8140 1503 27010 84833 84836 259307 133688 340075 133686 92483 55065 9481 284716 84869 55066 346606 9016 341392 9495 728568 3704 3705 3706 3707 400569 122970 3708 3709 1528 9023 113612 26119 401494 100131187 2864 3710 3712 1537 92014 55090 64801 132789 64802 2877 83549 2876 1545 2875 79048 1543 23097 119391 1549 1548 2879 11081 9045 9049 79071 64816 79077 1557 5917 1555 123876 1553 1551 51504 3735 1572 79064 27430 1562 3745 84890 3747 1583 9061 1582 1581 9060 1580 23600 1579 1577 1573 5950 1594 1593 122481 1592 1591 5948 1589 54363 1588 79642 1586 79644 1585 1584 55697 55217 56548 3767 1109 5947 64174 729020 125981 147323 1595 57407 6804 3790 1131 204219 6818 6817 6819 10768 125965 57412 6812 706 126410 80201 55245 27165 80205 3313 389434 3795 6821 6822 160728 1152 166012 55256 1149 5501 6834 6833 133121 5507 6837 80219 3340 1160 83733 80221 1158 10715 80224 6844 4669 50814 6861 4682 4200 55270 2023 114876 388121 81537 81544 55276 114880 441282 114881 27158 114883 10728 10720 4694 4695 4696 23683 25865 23205 51241 2027 2026 759 5538 11224 10380 3376 25873 25874 760 761 762 763 765 25870 766 4697 768 55613 5549 11238 166929 5563 5565 64579 2052 392636 771 56953 773 775 776 777 55627 84188 91703 51268 6888 89874 9917 9915 790955 25852 783 784 89869 2058 788 6898 57818 158067 25828 9942 8611 8612 391365 5587 339983 790 54797 314 113189 8604 316 10331 5593 90871 9953 9951 25830 51292 51293 56985 51295 57834 79603 79602 4257 5105 4258 5106 8613 4259 100131801 64131 64132 9962 9963 2098 56997 10317 335 336 337 9957 9955 6448 9956 10797 9971 25816 8644 4289 23632 10327 196743 344 345 348 79626 91734 9967 7306 8639 6472 11185 23169 93034 222537 283927 6470 337876 142891 353 8647 51647 10 13 9997 15 9514 19 23179 494143 8659 22 5162 5163 9521 125061 5164 93058 5165 9524 26 28 11164 11163 5160 5161 375 377 51660 6007 9517 6006 11165 30 33 7352 34 7351 35 36 37 38 9536 7358 39 7357 7350 384 54704 7363 7365 47 7364 48 7367 7366 10295 7368 160287 8692 7360 84129 10296 51686 50 51204 54 9551 5198 8226 7378 9556 25796 7372 7371 85441 109703458 51218 7385 7384 127281 7386 7389 7388 7381 8228 9575 23597 7390 9572 90809 23590 221264 2939 2938 2937 9107 55163 9583 79133 2944 2941 146850 1610 2940 27124 26275 29785 2949 95 2948 120227 2947 2946 1615 92579 158833 9110 2954 2953 1622 388931 2952 1621 2950 26289 29796 9108 1629 92126 79153 79152 27109 80146 1635 84987 1633 1632 26251 80142 1638 55191 55190 64902 134429 1646 1645 1644 403313 80168 2987 79178 3837 26230 619189 377841 2998 1666 2997 2992 80150 9167 130013 93492 93010 2526 4705 4706 2525 2524 4707 2523 4708 81034 4709 4700 4701 2529 4702 2528 2527 4704 26227 26229 4716 4717 4718 4719 84532 2531 4710 4711 4712 4713 2539 4714 1208 2538 4715 25902 23729 22874 22876 2548 4728 4729 79777 80765 2542 54477 4720 55328 4722 137872 10411 4723 10894 4724 4725 4726 25915 54480 6916 55331 123688 57515 4731 4736 22856 728294 4750 378884 3420 54490 3417 445329 79799 55347 55349 10873 3419 3418 66002 2584 144193 2583 2581 54020 81616 80777 1244 3422 80775 3421 246181 4758 4759 91452 339221 2110 2593 123264 2592 55361 10855 2108 57546 27284 2588 10858 2101 6945 6948 6947 2109 5631 80308 80306 2597 113451 284486 7804 5625 10861 66036 348158 5641 132158 2132 2131 84701 5634 340665 57571 114757 145482 2137 2135 866 10840 10841 5660 115677 23324 154807 51360 338328 126328 873 874 51363 875 10498 4329 162417 6520 25994 2166 116519 883 54884 6513 405 406 6515 6999 6514 4338 84274 55739 142827 64210 25961 126792 2173 2172 644096 2171 51380 23305 2170 54893 100303755 410 55744 412 2169 2168 414 55748 415 8703 416 8704 54898 8702 8707 6528 8708 10476 8705 8706 10478 25979 4363 5210 5211 8720 5213 3034 3033 25974 2184 10007 253782 3028 341947 8714 6535 4357 6534 427 11332 29090 56603 5207 6539 5208 6538 10003 5209 29095 10005 6555 5223 6554 5224 3038 435 3037 3036 5214 438 6548 285362 5230 5232 80704 3052 440 29078 56623 56624 443 445 5226 192286 6573 5244 3067 751071 23743 55300 79751 55788 55304 55301 151742 5236 7416 10434 6584 6583 5255 25939 5256 113026 5257 80724 55790 10449 55312 6579 90527 5261 3081 5264 8776 28976 471 5260 118672 51763 9615 53947 6120 126282 6122 6124 6123 6125 92292 3099 3098 414149 30815 152100 8310 6130 6133 5286 6132 5287 6135 11283 5288 6134 11285 6137 6136 131669 57089 28958 498 23262 51300 51302 6128 8789 6129 8309 5294 6142 9653 6141 6144 9651 5297 6143 5298 6146 6147 5293 200895 6139 84693 6138 51312 6152 6155 6154 11261 6157 6156 6159 6158 119559 84245 6164 6166 6165 9673 6168 7498 6167 9677 6169 65977 6160 221357 6161 50484 50486 84233 6175 9200 6176 65985 6171 6170 6173 387712 25880 150379 1719 1718 1717 1716 347735 347734 128486 9217 23236 6181 1723 3906 55711 1728 1727 9227 27249 55289 1734 27242 1733 120103 390916 9218 1738 1737 1735 7054 641371 112950 1743 80232 10825 80230 8396 375775 57001 8394 84618 8395 3939 3930 51703 1757 9256 9254 9255 57494 57491 57017 27231 3948 57019 3949 27235 27232 27233 57016 2618 3945 166785 7084 7083 7086 283209 60678 4800 4801 3954 2628 4802 51727 53905 130367 92259 93100 124975 124976 2632 80270 51733 2639 2638 80271 373156 2644 1312 2643 2642 29841 2641 574537 3972 3992 1327 493753 4837 2653 51750 4830 4831 4832 4833 4835 1329 30833 1340 51085 51084 1337 4846 1339 285440 4860 1352 1351 1350 51091 51094 55454 1349 2678 1347 1346 1345 51099 22977 65263 22978 2694 377677 10998 2687 2203 2686 1355 83930 1353 4862 10993 5730 1374 1371 55471 169355 5728 152926 124872 5723 284541 5740 2232 1384 2230 441024 10975 58510 29104 2224 1376 57664 952 1375 2222 953 954 955 956 957 548596 219970 116832 58526 284129 2235 5742 5743 7923 4899 221823 22934 22937 6610 3101 6609 10955 28234 978 161823 22949 613227 26063 84812 10965 55034 167127 501 57214 389203 6611 506 6616 509 26061 284184 64795 5783 2274 2271 54996 253430 51000 54511 54994 513 8802 514 79814 51004 515 10131 8803 516 517 8801 518 10135 7957 200916 8821 521 51495 522 7965 55856 5305 284161 349565 6652 219541 10591 3145 55863 8824 79837 539 8826 54539 10599 266722 5330 5331 5332 91942 5333 200931 3155 54545 549 8833 23408 23409 3163 3162 3161 256987 3158 3157 6667 5336 90639 440567 23410 3176 90624 6677 10101 10588 8871 65220 4035 4036 6697 570 51061 10558 54578 54577 54576 54575 135154 8869 8867 54579 135152 8402 4047 51070 51071 51074 100 586 587 51079 8879 10560 4051 10090 8897 8898 4056 64711 593 594 29940 84320 4048 150274 6241 6240 8424 29956 4060 29958 124 125 126 127 128 4074 54928 405753 6257 100996939 29923 23389 29920 130 131 132 253017 51422 347411 4082 1800 23396 60386 1807 1806 7108 54949 138199 29906 26873 64757 150 152 158 159 10057 51447 197322 10062 10063 64768 8460 29914 54963 53630 8459 6296 64777 178 55825 1836 9334 9331 64781 183 200576 54981 189 1841 51478 51477 54988 10048 7167 91012 7166 9348 9349 191 90161 196 57107 26031 84725 83875 26035 22908 81693 51805 8029 7179 22928 7172 7173 2713 2712 81689 2710 79369 56267 10948 2717 10941 440957 27349 10908 374569 122622 57128 4907 148811 2729 117283 112812 9377 22901 26027 1890 112817 9374 26020 2731 83884 2730 83401 2739 50506 9380 8050 58472 63826 2746 2745 2744 2740 58478 50512 102157402 50515 2747 2760 9391 92370 9390 259230 9394 59339 59338 2752 1428 94103 96764 2771 29967 27304 2770 59344 94101 27306 29968 3615 4947 3614 4948 3613 2766 3612 1431 84300 4942 4946 4958 5805 3620 83440 4952 4953 54905 3628 54902 7376 6256 7421 5465 6095 51588 5468 7329 6613 9562 1892 7157 1373 5009 383 8895 9468 26279 1460 10809 590 23446 126969 1459 201164 1457 81579 2820 55326 56894 57104 56895 51365 11343 6901 253558 158835 22925 200879 56261 63874 64600 57110 204962 27132 23171 1103 79887 248 23175 255189 254531 79888 283871 30814 10423 8398 8399 64850 5320 5321 9489 5322 255043 1120 9362 283748 80821 55500 114971 55224 5833 5319 1119 8443 64900 3032 3030 79143 55750 100137049 149998 122618 10400 54947 154141 9926 43 9663 374986 8694 129642 23760 23761 162466 23646 84803 84649 54675 347516 8605 51205 5337 11145 5338 81490 83394 23659 57153 9791 23259 57678 84879 58488 150763 50640 50487 151056 10390 137964 9600 114884 80736 80339 1040 56910 117245 56994 10554 57605 10555 8904 54979 5130 8760 10162 114879 123745 171586 84895 114882 85465 2819 5920 5335 6233 3320 5577 7316 5500 5518 7311 7314 5566 85007 1504 1514 1634 440387 63827 960 176 3339 5644 9862 6907 8648 10891 22880 123 23054 60481 5166 8202 948 84246 1024 1387 9443 9442 9440 9439 6604 2033 51003 8800 10499 51129 9477 90390 10025 7069 63924 892 2167 79718 2180 8841 9370 10001 25942 79611 2068 4023 29079 2874 5346 5469 6319 133522 9282 9612 3991 9611 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds 54490 445329 79799 10327 55347 23169 27306 54659 54658 6783 10249 10 119391 1544 494143 27284 123876 221357 51504 27430 348158 4143 4144 389396 7358 7363 7365 7364 7367 7366 6799 7360 54578 54577 54576 54575 6818 6817 54579 6819 57412 6822 27233 55748 2939 79094 2938 2937 2944 2941 2940 54928 2949 124975 2948 2947 2946 373156 2954 1312 2953 2952 11046 574537 2950 10720 4837 54657 26873 80146 10380 8460 9 8459 2678 116285 54600 9446 54988 2687 2686 191 7172 391365 29104 10941 79017 2729 25830 219970 4552 653689 92292 4257 84836 4258 4548 133688 2730 4259 2098 341392 50512 167127 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis 121278 438 1644 7166 15 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes 596 3162 598 114548 7295 4791 9447 4210 24145 58484 9051 29108 22861 4790 351 10910 10628 5027 834 3326 5970 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model 9481 7350 9016 7352 7351 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects 27338 119504 246184 51434 51433 5925 7321 25906 11065 8697 7324 10393 6502 29945 29882 996 51343 51529 8881 64682 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation 2617 7965 3376 5917 9521 9255 5464 2058 1615 3735 5859 7453 16 8565 6301 3035 2193 833 6897 4141 51520 4677 10056 7407 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 3082 5906 5908 4233 1398 1399 85440 2549 5879 2889 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 596 4851 598 1387 1950 2033 374 6667 5154 4780 7975 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 50814 6720 7108 1595 6307 51478 6721 1718 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA 5777 151888 8764 5781 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 6160 6189 6161 6233 6218 6217 6175 6176 6171 6170 6173 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 1938 1937 6235 1936 1933 1917 6227 1915 6229 6228 3921 6122 6124 6123 116832 6125 7311 6130 6133 6132 6135 2197 6134 6137 6136 140032 51121 4736 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation 2247 9982 83888 2248 2255 2252 27006 143282 2246 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border 6657 1749 4602 7022 7021 1499 7020 89780 5460 2249 5077 7545 4487 5081 652 83439 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) 7248 10000 208 7249 207 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism 6611 57153 55349 100131187 3712 144193 79814 2875 79048 2593 200916 9045 7965 5917 3735 6233 113451 84890 5625 9061 9060 549 23408 57571 256987 10841 54363 6230 6232 6231 3176 6234 6235 55217 6227 875 6229 4329 6228 162417 6520 51061 57407 883 9861 6999 5682 5683 5684 5685 5686 5717 51074 5718 586 5719 587 27165 7311 11047 389434 51380 10213 5713 5714 6821 7979 1152 593 5690 594 55256 5691 5692 5693 5694 5695 8424 5706 5707 29958 5708 1160 5709 6528 1158 5687 5688 5689 5700 405753 5701 5702 5704 5705 29920 64087 3034 2184 56922 3028 6535 4357 6534 121278 138199 6539 85007 6538 10003 4967 11224 5827 857 3376 1468 25873 6188 435 140801 6187 6189 438 4507 440 2326 189 443 445 5831 3067 7166 23743 9349 191 6191 51268 1491 6193 6192 89874 6194 6583 5860 2058 6898 2346 22928 7173 25828 5859 90527 3081 56267 339983 3921 8604 118672 374569 6122 6124 113675 6123 4552 6125 1036 112817 6723 4548 2731 6130 83884 6133 6132 5409 50506 6135 9380 27034 58472 6134 2197 63826 2746 6137 6136 3242 2744 131669 51121 140032 635 58478 8942 2747 6128 339896 6129 6201 6142 6203 6202 196743 6141 11112 2752 6144 1428 6143 6146 7306 6147 1081 11185 6139 29968 6138 4947 6470 6152 6155 4948 6154 6301 6210 51151 6157 6156 10249 6159 6158 51065 4942 4946 15 84245 6205 6164 6204 6166 6207 3620 6165 6206 9673 6209 8659 6168 6208 4953 6223 6167 10247 6222 9521 6169 6224 125061 6160 23521 6161 26 6218 51166 6217 6175 6176 6303 55526 6171 6170 6173 4141 347735 4143 36 38 6181 1728 384 1734 1733 120103 10295 1738 1735 7054 1743 51686 1757 9255 57494 223 27232 60678 51520 2628 8528 1610 53905 26275 92259 2639 1615 2954 51540 1621 8564 5053 1629 4837 2653 1892 262 7157 1373 5009 383 1638 64902 23446 275 1644 51091 7252 23498 619189 65263 7263 80150 130013 51582 2806 10993 2805 10157 169355 152926 5723 23474 26227 5092 1384 58510 10165 10166 548596 7296 7299 116832 8140 259307 10955 284716 123688 57515 4736 501 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 4803 6774 4914 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 240 5743 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production 11311 25 1020 5577 85440 7975 23468 4602 9585 23046 24137 1062 64837 10019 26153 10938 80005 147700 998 55605 55604 91768 221037 139818 22920 55614 146909 5566 55619 7465 3660 55582 23303 23028 29127 10112 3659 8165 9371 3442 221458 3441 9493 3440 25970 547 10362 3439 51317 11216 829 9927 4097 55083 3046 3045 81928 3043 3452 23764 3451 81930 2624 3449 3717 3448 2623 84643 830 3446 832 3445 3796 3797 3444 113220 3831 3443 3798 3832 3799 7157 3833 3456 3834 2627 2626 3021 3835 90990 285643 161882 23414 23095 10749 3048 3047 4778 50808 81704 23348 124602 56992 1795 23186 1794 30846 30845 89953 55669 11004 64780 5890 64145 64147 9732 57572 10603 5889 140628 1017 25942 8968 1793 11127 5573 5575 5576 2625 5879 5567 5868 5568 3066 3065 653604 3705 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion 11181 248 8513 8972 8544 2980 280 119548 27159 1118 278 279 2984 1056 2981 5407 5408 5406 3938 6476 1208 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 8893 1965 8894 8891 8892 1968 8890 1967 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation 7316 7879 5868 4843 26276 7311 7314 6233 3837 3836 9146 51606 11151 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling 5908 6888 5034 6950 829 7297 3717 5478 759 3181 9049 9987 6775 3185 5062 3936 654483 3458 5898 3313 6845 6647 6627 6648 998 4282 6175 4507 5055 4001 3595 3594 375 3593 3592 1072 27250 2939 302 3716 3586 1265 9446 5721 4478 5306 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 7316 6502 7311 7975 8454 7314 9978 6500 64839 6233 571 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 23428 92745 6511 6533 6510 206358 84889 6509 55089 117247 340024 10991 6506 6505 54716 120103 6507 9056 9057 8501 153201 6541 6520 81539 123096 23657 55117 56301 11254 6512 6539 11136 6519 124935 54407 8140 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 55683 5929 6907 9968 57678 55689 9969 8648 10891 10445 9739 5925 94239 9070 729359 123 23054 60481 10555 22976 25 5166 54934 11168 9757 8202 54145 948 58508 8331 8337 8334 8335 84962 1020 1810 51562 84246 26993 8341 8342 8347 8348 8345 29915 8340 79447 1024 1387 8338 9443 259282 8473 9442 2494 9440 57325 84148 85236 8349 9439 51105 22822 1050 51230 80335 6871 2033 8370 51003 6256 284058 8800 10499 51129 9477 4221 3013 90390 10025 255626 55617 7069 3021 63924 91272 892 3018 3017 2167 3014 10474 57104 79718 11343 2180 8841 474382 9370 10001 23175 8970 8850 128312 55766 79611 8968 4023 23411 3054 26009 29079 2874 5346 7403 5469 6319 133522 23067 9282 112869 653604 84661 2648 9862 84649 11091 9612 4297 30827 3991 9611 8085 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors 10797 9390 1528 26119 4594 113235 83666 27304 92014 84875 6472 200895 64802 6470 10135 119391 51248 10243 349565 6948 6947 80308 1719 10840 1727 27249 683 10588 65220 4036 113278 6513 5646 54 6515 4338 55739 10560 27231 160728 326625 166785 143 55163 83594 79668 93100 4363 23057 54956 64087 5096 25974 686 8884 5091 56922 3141 31 32 60386 5095 4837 8566 1504 55191 5826 160428 79178 80704 54981 440387 54625 2694 6573 9446 55788 81034 81693 8029 2350 23475 4522 4524 55312 441024 128240 952 316 25902 4907 8034 8875 51293 8876 4552 5167 5168 5169 2194 80025 27010 284439 254552 55328 80347 4548 5644 53354 79877 79581 79646 56965 133686 60496 79717 55065 55229 60490 9962 9963 55034 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated 51231 1849 1848 1846 1845 5518 5594 5595 5519 5515 5516 5528 5598 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response 1432 79651 3569 5045 10769 6868 9332 4627 3586 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 5928 639 902 4343 192669 23112 27327 26523 27161 2877 192670 57690 5305 10769 25904 6790 4850 57060 4292 472 6233 94241 79837 4848 4849 117584 10419 144715 8649 5810 10650 5932 5933 5934 5395 11073 55571 84701 28984 55215 6117 7316 6119 6118 10542 80196 4194 1029 8794 8795 7532 8550 7531 8793 8797 1121 253260 389541 355 22974 28956 4193 246175 57521 1111 6009 4869 10498 5052 64065 9656 8445 9891 9099 5608 10524 7486 9540 8851 7001 5982 5983 891 2353 1263 125965 23368 55240 84126 27166 5518 85456 55367 55004 27165 835 7311 839 7314 29117 64769 23019 1820 1026 53632 983 2475 1386 843 5984 5985 604 58528 5170 5883 55835 5884 116028 124446 54971 5875 5876 10397 9212 7156 27113 5892 9337 5366 4683 7159 637 27154 10848 79109 133383 4436 5300 890 8900 3486 10971 3364 79370 51422 7161 26155 995 57103 341947 7832 84289 1616 57472 641 55615 51499 9125 7862 5562 5564 2177 2176 144455 204851 1874 26013 56950 7534 29883 11200 10111 4361 5571 7994 64223 7874 54541 207 4697 1643 1763 7529 665 2810 545 5325 80010 1432 5563 1647 5565 25946 133746 672 79733 387893 5600 317 5457 84883 5458 9156 64121 5111 8621 23774 83667 8738 91875 28996 4512 332 4513 147923 4514 143686 8626 6446 10670 83695 5371 63970 153129 580 112858 581 3622 900 51755 10325 9377 3276 10000 2744 6908 5931 7533 129685 404672 6872 6874 6873 1107 208 6749 1108 6881 6880 5430 6883 9997 5431 6882 5432 8148 5433 6884 6917 54815 6794 51497 11198 6875 6878 58484 50484 83860 8812 6877 53615 6879 834 1022 2963 1020 2962 5436 6921 5438 6924 5439 6923 7469 138474 8178 1387 54205 6829 8396 6827 9150 7248 7249 1025 51616 25920 54457 51224 7936 90809 51230 57459 904 905 4331 2033 898 9134 79813 9219 1327 7157 5440 1329 5441 1340 1460 1337 2966 1339 2965 1459 1869 1351 3725 1457 1350 5434 7027 5435 5437 1349 5519 1347 1346 2968 1345 2967 5515 7029 5516 5527 9167 10919 1017 5728 1027 2071 2068 2539 2821 83990 7296 7295 3066 3065 613227 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism 1158 1152 548596 6535 6534 6539 1160 2593 6538 2628 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE 7098 CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes 5928 5929 10445 595 4790 10419 5970 10498 10524 64769 1386 27154 84289 7862 56950 6187 7994 387893 23774 29943 22992 84444 79084 57634 27097 55693 55578 84678 51412 9767 7468 10196 9643 54496 51780 83933 54014 353238 55352 23030 3276 10765 64754 117143 10856 11143 6944 5978 8464 55929 93624 6595 23133 23135 4297 55250 6597 80314 55257 6599 10629 6598 55818 11240 26610 55683 317772 23587 6907 9682 57504 55140 55689 83852 8648 85235 54859 5931 79918 9739 8242 51111 23326 23569 94239 55167 10933 9070 64324 23210 1107 55170 23338 10943 9869 56943 84159 84864 9913 55869 1108 51147 6881 51702 6880 55193 8284 6883 25855 221613 55870 23522 8295 23081 54556 54934 56970 92815 9757 8969 54815 56979 4791 8607 84193 440689 79960 10902 79723 196528 7404 6314 29072 53615 339287 58508 84787 8520 8331 8089 8337 5253 8334 63976 8335 221656 5926 5927 80854 1810 80853 51562 54904 8518 8341 8342 8347 8348 8345 8340 79685 6839 1387 60 8338 5077 8473 79595 57325 84148 85236 6601 8349 6603 6602 6605 6604 9575 10284 64426 23028 51230 57459 86 6871 2033 8370 10362 51317 2146 79813 284058 9219 10499 55729 9112 3717 3013 8819 255626 3018 3017 3014 10474 79718 121536 23186 8289 8841 474382 10919 57492 1019 8970 8850 128312 55766 8726 8968 3054 26009 1788 2874 7403 2122 23067 3066 3065 112869 653604 51742 84661 2648 11091 9612 9611 23512 8085 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 27338 119504 246184 51434 51433 9184 991 4085 701 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules 23443 292 2030 293 23568 55343 389812 10999 3933 286256 7355 28965 222962 51000 3177 8884 9197 9153 9154 84912 23169 55315 347 11046 51248 10559 376497 402 291 64078 347734 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle 5295 5296 5783 11180 7126 1362 390 57584 29766 22852 6093 394 1832 57449 222584 55704 11188 3895 54514 10970 857 55789 8502 8301 91544 81839 27316 9231 9352 23513 57216 56667 10505 1152 253980 23592 667 1828 1969 9462 2319 2909 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants 3815 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins 3248 240 4048 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) 6528 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor 581 4916 25920 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 285195 84679 6550 6553 389015 6548 6549 23315 10479 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 3929 929 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 7450 11093 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 10250 6510 7919 6279 91452 4627 6280 7074 55240 55004 1499 2889 5594 5595 6654 10817 9212 9184 991 5300 4085 701 995 5580 7514 5578 7534 5825 7529 1432 5600 332 8776 4548 8452 9462 23081 348995 57122 55746 9217 23279 79023 6396 8976 11180 7126 1362 10226 390 57584 29766 22852 6093 394 1832 57449 222584 55704 11188 3895 54514 3930 10970 8503 5905 55789 8502 8301 91544 81839 27316 9231 5903 9352 23513 57216 56667 10505 253980 23592 667 1828 1969 2319 8086 79902 3954 65124 25909 9183 9181 55200 79658 399693 253959 5930 10652 3998 23616 124540 367 115703 201176 2316 10788 57514 57636 57630 55219 64283 10424 10787 143098 4628 4629 57405 55227 57522 4983 26092 1495 66008 22865 79784 10403 124997 58504 81624 1213 1124 80776 1123 10409 55114 6811 4637 708 5519 4638 22836 4650 5525 4771 5515 6709 5526 27289 5516 10979 5527 114793 5528 4646 4649 5529 4660 11140 91687 55914 57551 84904 79682 26084 57679 6711 5747 6714 5880 5881 114885 2010 2491 55023 57569 79598 55143 3336 284119 2245 27145 613 6722 5756 26050 92799 10602 57579 2017 10726 27035 10963 4690 115557 1063 1060 151648 55843 752 54874 1058 55968 182 10134 4688 55845 10254 4689 4580 2040 55971 51133 54763 55852 89846 11113 10144 3688 9901 51138 85360 8936 5337 1080 348235 5338 64333 7984 25963 23421 147179 11329 51143 79834 5295 537 9912 5296 5783 64105 10818 2185 5290 23433 101059918 116984 79822 6655 9928 11214 10006 10489 23526 6793 5585 6434 5586 286205 10458 10451 54438 9815 10211 5216 5579 5217 157285 29062 9938 23779 7410 9710 51291 5590 10109 54443 9826 9824 8655 90627 9828 7409 8826 22899 1781 3320 5361 64130 5364 6453 8997 1778 8874 124056 56990 3183 695 699 7535 10552 8987 10672 3163 140735 10435 9738 3071 25936 4162 9793 7532 7431 7531 9855 4168 80728 23332 25813 79980 6232 224 79869 8773 54908 5500 10093 5347 4296 11060 22919 10092 7444 10095 10094 7204 10097 9743 4659 8654 10096 94240 23048 5048 354 29941 85415 83478 151246 9735 84681 6242 5518 7454 11075 7456 9754 5289 120 84317 143872 9748 27 9886 29 9644 1152 23268 220134 57082 54820 64857 5501 23380 23141 23263 221472 5170 6249 9639 51306 2697 9411 7112 8440 9414 5058 28964 94134 200894 388 389 9528 54821 5063 23122 23365 23002 391 10971 644150 392 393 999 128272 23129 395 26999 396 397 398 3326 399 121512 55920 51566 84364 10298 171177 51209 148170 23013 23256 94274 23370 857 25791 1829 9322 23229 8476 10152 64411 23221 23344 3817 89839 23580 84144 11243 70 2810 10395 51466 71 10398 51347 10276 55701 9318 2802 65992 5099 7037 9459 10160 10163 9578 11130 25894 55831 128239 1729 11135 89941 8239 51479 54509 55839 55717 56924 87 8379 55160 10928 91010 9341 57580 1855 26030 10811 55288 10810 80243 55166 1730 56254 79019 1857 1856 22800 9235 93663 9475 8027 26049 9590 57473 7170 7171 57591 79003 1742 55055 123720 26286 80115 81565 1627 9367 158747 57120 8153 57480 117289 147841 84986 50855 3932 343578 50619 50618 9497 157769 9138 22906 30849 221178 401541 7533 27237 55075 653361 57498 257106 94239 84612 50508 378708 6472 153478 1780 79172 57144 114822 57381 1536 1535 29984 1894 445582 58480 23092 25 3728 7415 30851 2631 2873 1783 144402 347902 4952 4810 83540 80152 50649 29843 2886 50650 5910 54145 3619 7428 152273 79180 64946 9055 808 23191 80179 1445 23074 8331 23075 8337 23197 8334 3984 8335 3985 103910 51517 5924 8341 85440 8342 908 8347 8348 8345 8340 60 8338 10376 10574 10576 85236 1062 8349 64837 80005 147700 998 139818 55619 23028 29127 898 8370 9927 10499 81930 4221 3013 84643 832 3796 1629 3831 3798 255626 3799 3021 3018 3017 3014 81704 23348 26230 1795 1794 89953 55669 11004 474382 2909 9732 57572 8970 128312 1027 55766 116985 63916 8968 1793 5879 9146 387 7879 5062 4722 653604 4001 1072 DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells 4851 5928 5929 6907 57504 2033 5931 9219 9070 1107 9112 9759 4221 55869 1108 861 864 84441 9794 55534 54815 4853 8459 3725 22938 53615 79718 10046 7124 8535 8841 4772 4773 4094 10538 51564 6348 6304 10013 10014 8850 6045 79885 3567 3566 3565 2113 648 7528 6015 3662 23466 51621 30009 1387 1912 1911 5451 5452 9734 2625 3596 80012 57332 84733 6777 6776 6778 2353 6775 3516 3458 83933 3066 3065 3595 84661 2648 11091 9612 4297 6597 9611 57459 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration 3417 48 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine 64841 55577 2673 6675 5973 51005 5238 9945 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling 10133 8772 7186 841 8737 8717 29110 9099 9641 27005 220213 330 331 10616 142678 56957 7132 7375 55072 81858 1540 9825 7128 329 7124 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex 90780 8313 5929 283149 26108 6932 2033 8370 94239 9070 4221 3013 864 255626 8295 3021 9757 8607 3018 3017 54145 3014 8331 8337 8334 8335 474382 8341 8342 8970 8347 8348 128312 8345 6934 8340 55766 8968 1387 8338 10524 83439 85236 8349 1499 3065 653604 84661 11091 7088 7089 8290 79577 6597 7015 7091 7090 123169 4609 51176 607 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins 4284 360 375318 361 362 363 364 282679 343 366 358 359 89872 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome 7316 5687 5688 5689 5700 5701 51684 1452 5702 5704 9978 5705 9861 5682 5683 5567 5684 8945 5685 5568 5686 5717 5718 2736 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5566 5695 5706 5707 2932 5708 5709 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 7316 7099 929 10133 9641 353376 7311 23643 7314 148022 6233 10010 29110 7187 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes 1435 3458 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi 4249 2525 25834 1081 64377 338596 51046 3972 4248 4122 6484 8128 2517 6480 2683 11282 11320 9486 4124 2530 9334 9331 8703 8704 8702 4247 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation 10454 64127 3551 9261 6197 6196 1147 6195 4205 8517 4208 10392 79155 51231 2002 1849 5599 1848 9252 1846 1326 1845 5609 466 6416 5601 257397 7867 8454 5602 5606 3725 6233 23118 4790 5519 1432 5515 5516 5600 5528 5598 7316 23291 6885 8767 5608 7334 7335 7189 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway 117608 5928 640 5929 4336 79862 7621 9968 650 894 9969 896 340252 51385 902 171392 7633 5925 148156 23314 79943 7626 7625 7627 3280 126375 374900 55762 79973 7638 348327 7652 57711 55778 10224 25925 7422 163732 2593 221785 374928 200845 148103 3064 694 79755 55786 79759 140612 2101 4149 158399 10432 7673 5494 25937 169270 463 79744 619279 30818 728957 84449 7678 117581 8784 7692 7694 5275 7697 84701 7699 163227 163223 79088 84676 84436 84671 54807 163255 23269 59269 54811 55900 5054 8317 11059 80095 10172 7004 9668 7003 7005 10498 201514 94039 5079 115196 23493 51333 126070 7025 26974 65988 405 25888 406 728927 6515 9861 23460 5682 23462 5683 286075 5684 7039 5685 126068 5686 374879 127396 28514 2811 5717 51592 3516 55713 5718 10168 5719 1499 9464 114907 11047 84838 10213 26152 163081 5713 374655 5714 7057 7979 7291 57474 5690 91120 5691 7050 5692 169841 83744 5693 163071 5694 83746 5695 390927 147837 7067 5706 1998 5707 1997 84626 5708 80264 5709 51176 1750 26149 4851 5687 63934 5688 163087 5689 79027 144348 3958 5700 60436 5701 3726 84874 5702 84870 5704 80032 5705 93134 199692 163059 2891 92285 92283 256051 341947 5915 5916 146713 341359 3977 349075 2660 163049 163051 4839 163050 654254 901 30832 65243 7514 79891 2669 79898 4605 7534 23619 65018 100287226 388536 10308 124411 10781 10780 207 4852 10782 162966 7529 100289635 388569 388566 388567 1432 388561 3549 284309 284307 400720 58500 5600 10520 4878 3562 3559 3558 147741 1378 253639 284370 115509 90233 1392 57677 3329 79230 339327 339559 9978 146434 26053 83737 353274 158431 57209 91584 7710 387032 27153 7703 4435 219749 10370 220992 5775 7712 442319 7711 79818 10138 266743 148254 5308 90827 7728 2290 23429 2737 7743 148266 2736 148268 80818 342926 23660 6886 7733 54778 7738 23439 730087 7752 6662 7753 2063 441234 55634 51276 353088 7745 56729 7988 7748 136051 10127 7761 7760 91975 7762 114026 3164 339500 4004 4488 100129543 129685 6872 7755 4005 6874 7757 6873 55888 23327 7770 8861 219578 7771 7773 90874 162972 148213 3174 6749 148203 51058 148206 6881 7525 6880 55659 5430 7766 6883 7769 5431 55657 6882 7768 5432 730291 8148 126231 5433 55663 6884 579 6688 6917 10794 10795 7539 7552 51497 7551 9975 11198 6875 285267 6878 285268 50484 4287 83860 8812 7556 6877 255403 7549 57615 90649 6879 100131827 7561 7565 7323 122809 7567 7566 7559 2963 8409 2962 94115 7571 7574 29959 5436 7568 54925 6921 8431 5438 7582 6924 7101 7587 5439 6498 6923 7586 6497 6258 84108 8427 7594 4086 7469 7596 138474 4087 4088 8178 4089 9534 7592 142 126382 84333 112950 199777 7122 6829 64750 4091 4092 8396 84124 2904 2903 6827 54715 5196 9310 8463 9150 3930 9314 440519 10273 440515 1025 162239 181 54989 152687 51616 8013 8493 170960 57343 25920 125919 54457 147948 51224 147949 7936 9358 170959 26048 80108 80110 221044 6097 342132 285971 7182 4800 6096 4801 1876 904 4904 905 1875 4802 282890 344787 92595 80139 168417 1649 79175 93474 84527 84765 57154 121340 58491 58492 1437 27300 59348 147929 340385 84775 1327 2289 1329 1340 1337 1339 1351 1350 8312 1349 5519 1347 1346 1345 5515 5516 5527 5728 2625 5979 182 3172 613227 4609 639 4343 192669 23112 27327 26523 27161 192670 57690 595 861 6046 864 865 10135 7040 3845 5305 79047 7022 7021 83741 51741 339488 7020 284252 79837 7321 4790 25906 11065 8697 7324 10393 29945 29882 1436 996 27287 51343 51529 8881 64682 5970 27338 119504 1051 246184 1029 3569 6667 51434 51433 6934 23410 3654 6241 5170 6257 10971 51422 857 2810 5781 6772 9377 3276 10000 7082 2744 7533 208 58484 808 10628 834 6502 4233 83439 6657 1749 4602 7248 7249 898 9134 2624 2623 84441 9794 2626 55534 4853 161882 4854 4855 1869 3725 4778 22938 7027 7029 10046 9021 1019 1017 1027 5770 3458 6648 10769 25904 7222 4850 57060 4292 472 94241 4848 4849 117584 10419 144715 8649 5810 10650 5932 5933 5934 5395 11073 55571 28984 55215 6117 6119 6118 10542 80196 4194 8794 8795 8550 8793 8797 1121 253260 389541 22974 355 28956 356 4193 246175 57521 1111 6009 4869 5052 64065 9656 5588 8445 9891 9099 5608 10524 7486 8851 9540 627 7001 5982 5983 2353 2645 1263 23368 55240 84126 27166 85456 55367 55004 835 839 29117 64769 23019 1820 1026 53632 2475 1386 5594 843 5595 5984 5985 604 58528 5883 5884 116028 124446 54971 5875 5876 10397 9212 7156 5892 9337 4683 7159 27154 10848 79109 133383 4436 890 5300 8900 3486 3364 79370 7161 26155 995 57103 7832 84289 1616 57472 641 55615 51499 3630 9125 7862 5562 5564 2177 2176 144455 204851 1874 26013 56950 29883 11200 10111 4361 5571 7994 64223 7874 54541 1643 1763 665 545 5325 80010 1647 25946 133746 672 79733 387893 317 5457 84883 5458 9156 64121 5111 8621 23774 83667 81857 8738 91875 28996 4512 332 4513 147923 4514 143686 8626 6446 10670 83695 5371 63970 153129 580 112858 581 3622 900 6720 51755 10325 51412 83933 10765 5978 80314 5443 1081 55170 55869 55193 6794 196528 8089 5467 54205 3815 7341 7376 7068 5241 6256 7421 5465 2099 7181 6095 367 4929 2908 9759 5468 7329 5914 2516 7157 1460 1459 1457 9441 51586 6714 6722 2821 83990 7296 7295 57678 2877 5579 2064 1956 6790 8454 6233 7316 7532 7531 891 125965 5518 27165 7311 7314 6500 983 5566 55835 10018 27113 5366 637 5045 1514 1513 4697 1515 5563 10398 5565 9915 8239 6696 4322 5105 9862 6595 7562 4297 6597 285676 6599 6598 6908 6907 10891 5931 9739 348 404672 7695 7576 94239 9070 1107 65251 155054 1108 162967 25 9997 162963 7581 147686 9757 54815 6940 54145 284306 53615 58508 9422 8331 8337 8334 8335 1022 1020 8535 84246 4773 4094 197320 51564 7913 8341 10013 8342 10014 8347 8348 6045 8345 79885 25799 648 8340 7528 84911 6015 23466 1024 1912 1387 1911 8338 9734 9443 80012 57332 84733 9442 9440 23468 85236 6601 8349 6603 10155 9439 6602 6605 6604 9572 90809 57693 2932 51230 57459 7700 86 4331 6932 2033 8370 51003 2146 79813 9219 9477 162655 4221 3013 90390 10025 4208 255626 5440 23309 5441 3021 2966 892 2965 3018 100506658 3017 168374 5816 3014 29028 5434 284459 5435 90317 5437 155061 2309 79718 2308 10413 2968 121274 2967 54487 284443 6910 90589 8289 2572 9167 147694 2571 8841 1482 474382 80778 6929 147687 10919 90338 57492 100129842 10001 814 11335 4986 815 8970 816 8850 4988 128312 817 818 22869 25942 90576 2071 90333 2100 285349 55766 1493 353355 2068 81856 8726 1490 8968 6938 100131980 23411 79788 283337 22835 3683 1021 90075 114787 80317 29079 2539 146540 84914 84924 2538 57547 2874 2104 57541 7767 2103 3674 5469 3676 3678 90594 133522 1030 113835 90592 23067 146542 9282 847 440077 3066 1278 3065 1277 4303 653604 56242 57573 55422 147657 57336 84661 440073 10793 57335 2648 5888 11091 50943 6750 3484 9612 199704 632 389114 9611 51123 11105 23512 146198 8085 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis 5018 80224 284184 100996939 4694 4695 4696 119559 55572 55863 84233 54539 55101 29078 91942 25880 374291 4705 4706 51103 4707 4708 4709 4700 55471 4701 4702 126328 4704 4716 4717 4540 4718 4719 137682 4541 4710 4711 28976 4712 4713 57226 4535 4714 4536 90871 4715 4537 4538 4728 4729 51295 51079 3313 4720 4722 4723 55744 4724 4725 4726 25915 150274 4731 79133 55967 51300 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 4862 6095 9575 9572 8553 1387 150094 5187 8864 6097 8863 23373 4297 85457 7942 1628 406 1408 1407 5936 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion 51095 3028 54931 9692 60528 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway 7450 11093 196527 221914 9672 2239 375790 5657 2155 2153 2152 2149 2147 710 2266 3690 2262 5197 7056 3818 2243 2165 351 2162 3053 2161 2160 5270 2159 2158 2157 5104 8858 5624 5627 2817 10544 57126 2244 462 2812 203859 3827 51156 2815 2814 5054 2719 3339 5196 3674 2811 6609 6383 10082 6385 6382 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling 148811 9481 7350 9016 291 7352 7351 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle 6908 902 129685 6872 404672 22916 6874 6873 23327 27243 55048 23165 4686 128866 89853 10015 6749 9631 7175 6881 6880 5430 6883 5431 6882 5432 8148 5433 6884 6917 79643 1104 51652 51497 11198 6875 6878 83860 6233 8812 6877 51534 2959 2958 6879 2957 348995 9883 9525 57122 1022 2963 2962 2961 2960 29082 7316 5436 55746 6921 5438 6924 137492 5439 6923 27183 91782 23279 25978 79023 51271 7469 138474 10762 8178 92421 6396 8732 129401 8731 51160 6829 4927 155382 6827 9397 93343 9150 7251 5905 79720 1025 5901 5902 7311 51616 7314 5903 9688 23225 25920 54457 51224 7936 55706 23636 9972 11097 23511 8086 53371 8480 79902 51510 904 905 4836 4331 5478 7514 5440 5441 5045 8021 2966 2965 5434 5435 5437 2968 2967 2071 2068 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins 6612 51588 9641 7341 5610 4792 10210 7329 4791 10401 8517 5970 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 3251 1633 270 51292 271 100 272 4860 132 161823 353 2766 1716 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase 5567 808 5568 114 5573 5566 5613 5575 5576 5577 107 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins 4851 11093 9510 9507 4853 4854 4855 170690 170692 145173 57188 2591 143662 10417 118430 10418 170689 171019 54437 9037 4582 5199 4583 4584 7058 4585 4586 200958 157869 29954 727897 56999 29071 140766 11096 80070 10585 11095 9508 9509 10071 94025 339366 221981 140453 79875 81794 4588 55901 11041 4589 81792 9215 7057 56667 283463 3955 55624 9719 56913 394263 1605 11173 11174 80731 54507 92949 170691 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 23165 6139 6138 6152 6155 9631 6154 6210 7175 6157 6156 5430 6159 6158 51065 200916 5431 6205 5432 6164 6204 6166 9045 6207 5433 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 3320 6176 6171 6170 348995 6173 9883 57122 2963 2962 5436 55746 5438 6181 5439 6230 6232 23279 6231 6234 79023 6235 10762 6227 6229 6396 6228 142 129401 4927 7311 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 5440 11224 5441 25873 8021 6188 140801 6187 6189 5434 5435 5437 9349 6191 6193 6192 6194 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 5611 51121 140032 3843 2926 4736 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures 197342 7516 7156 84464 5892 7517 5889 4683 63979 23514 80198 55732 79008 79728 580 641 10524 7486 51750 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 348654 10635 5890 146956 9156 675 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 246213 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action 8454 3437 6500 3434 3433 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) 7316 137492 27183 91782 25978 51271 11267 51028 27243 84313 55048 92421 128866 89853 51160 9146 155382 93343 7251 79720 8027 79643 51652 7311 7314 10254 6233 51534 9525 51510 29082 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport 50636 537 23327 196527 65125 1187 57719 23200 1186 1185 1184 1183 1182 1181 133308 1180 476 79895 477 478 1179 479 51761 150159 51248 53822 7439 53826 155066 51802 7220 9114 7222 7442 53828 22802 7224 219931 7223 286410 7226 6233 9635 7225 57198 59341 480 79054 55283 1193 808 481 487 26133 2281 488 54795 57194 489 8989 482 55503 483 4308 486 162514 255231 523 490 57192 1188 491 525 492 80036 56302 526 493 527 51393 6717 57113 528 529 29850 10786 54822 7316 140803 285175 65266 65268 65267 285335 127124 23545 51382 495 496 144453 533 11059 534 538 535 10110 63982 9914 10079 50617 6263 6262 94015 57130 6261 23678 540 28962 5205 55515 40 41 266675 245972 245973 23400 374868 54831 23120 9311 5350 161003 259232 9550 7311 84239 7314 7809 444 23250 284525 55107 5348 5349 10345 8992 90423 57205 1831 344905 10396 10312 6340 6588 5894 9296 80727 57578 148229 27032 51076 53373 6337 6339 6338 55129 121601 203859 815 57101 816 817 818 6446 338440 51606 2040 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 7316 23370 50848 2280 5590 57530 7311 56288 7314 57154 7046 7048 6233 7040 50855 387 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection 59345 3708 3709 57105 2268 3710 917 2771 3055 6850 2770 136 2782 2209 346562 2781 1800 10800 2534 2214 6868 2212 2773 10681 7525 79651 5045 5335 10769 9332 4627 808 2678 1432 5577 2687 111 112 113 114 115 3569 5336 5613 2793 2792 2791 2790 2788 2787 2786 4067 196883 64174 2785 2784 5573 2783 5575 51764 5576 2778 107 108 5567 10768 109 5568 94235 55970 5566 3586 54331 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function 611 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 7316 2549 5295 10818 5290 2591 10253 8569 867 2247 5518 5335 7311 7314 6233 673 5594 5595 4893 6654 5515 2254 8074 5516 2249 3265 2246 10817 8823 5781 8817 26281 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 10454 64127 51231 1849 1848 1846 1845 4791 257397 8454 6233 351 4790 5970 7316 7099 929 7186 353376 23643 148022 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 57161 3725 57162 177 23118 121457 28511 80216 54106 5519 1432 5515 5516 5600 5528 5598 6885 7189 51295 51284 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) 11136 6519 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation 2247 10755 2248 7049 2255 27006 2246 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 57678 23175 150763 646486 5500 2713 2712 646480 2710 10226 64900 5567 5346 5568 857 2173 2172 2171 5499 9663 2167 2170 8694 80168 8228 2820 2169 2168 5501 84649 11343 51099 5566 392636 346606 150379 3991 116255 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism 81539 2752 6506 6507 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage 121642 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU 5045 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein 2931 56965 7341 7329 54625 143 54956 2932 83666 79668 84875 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism 64064 79611 38 622 65985 5019 3158 56898 3155 54511 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs 999 8826 808 10788 1495 128239 4221 1499 6249 5879 998 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste 6337 6339 6338 255022 119395 6340 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation 6480 4249 2683 11282 11320 25834 9334 9331 338596 51046 6484 8128 8703 8704 8702 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 891 8021 9133 5903 9688 23225 983 55706 23636 348995 9972 9883 11097 91754 23511 57122 140609 8086 53371 10783 8480 79902 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A 10000 208 2308 207 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry 5045 1514 8829 2262 221914 9672 6383 10082 2239 6385 7113 375790 59272 2719 6382 26762 3339 2817 7415 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR 2232 2230 112812 1583 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 2353 596 7514 7039 2002 1950 374 5747 2069 1956 1027 685 207 5594 5595 10000 208 2309 6722 595 1839 127933 255324 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism 9348 2137 90161 2135 4669 9394 9653 26035 3425 3423 221914 9672 2239 222537 60495 11046 375790 2719 3339 9953 10855 9951 8509 1514 2262 64711 6383 266722 10082 6385 64579 6382 2132 2131 2817 3340 9957 9955 6448 9956 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis 6844 3312 4952 6456 1785 375 7164 7037 9026 10053 8775 388552 3482 7163 6272 10618 286451 8546 6643 162 164 27131 81567 55330 2512 54885 152503 408 9829 8673 9685 26258 1362 2495 2647 8907 10717 8905 5878 84062 2804 51429 130340 9698 1176 23431 64746 1174 2580 23557 8301 25977 6845 5286 THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis 53905 857 405753 1734 389434 1733 7252 1081 7173 50506 1735 90527 51061 6528 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 6441 653509 6440 729238 6439 1439 1438 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 9738 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 22897 54930 5116 79959 80184 5518 93323 7277 23354 22981 4926 8481 114791 80254 85378 983 10426 121441 27175 55755 653784 54820 29922 10806 27229 440145 10121 10844 5566 55835 80097 55559 8636 11258 84131 4957 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling 146850 5058 59345 23236 5294 23533 2793 2792 2791 2790 2782 2788 2787 2786 208 2785 2784 2783 10681 51764 387 94235 207 998 10000 5330 55970 5331 5170 695 9459 54331 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling 1442 6772 9021 8835 5617 5777 6774 3667 5594 5595 4067 3717 6868 8651 8660 5770 1154 2690 5618 6777 2689 6776 2688 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis 84842 84274 57107 57017 51805 10229 27235 56910 51004 23590 56997 51117 79934 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling 5145 3708 144165 3709 1212 5534 5158 5148 409 7855 7976 51701 3710 8321 8322 4343 7474 8325 192669 8323 23112 8324 27327 7471 26523 4919 27161 6259 192670 5582 57690 4920 5592 5530 5532 2780 2535 81029 5216 2775 5579 6233 808 5330 5331 4772 7316 23236 6934 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 64750 9861 5682 83439 5683 5684 5685 5686 5717 5718 5719 94235 1499 7311 7314 11047 10213 5713 23513 5714 57216 7979 5690 5691 55970 5692 5693 5694 5695 5706 5707 5708 5709 51176 54331 5687 5688 59345 5689 6932 5700 5701 5702 5704 5705 57154 23002 2782 10681 5578 1175 160 161 163 1213 1211 815 5880 5881 6885 1855 7481 5879 387 5593 1857 1856 54361 50855 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation 8218 1212 1785 1213 2697 4646 1211 1759 1601 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription 200845 8312 57678 861 865 2099 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) 3595 6348 30009 6775 3458 861 864 8459 7124 4772 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease 1738 593 594 1629 152926 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants 238 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 7157 64326 11200 57060 472 6233 25946 7316 1029 4194 1017 1027 4193 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 1026 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 51230 5709 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport 55081 140735 9371 55764 79659 8100 51098 79809 26160 11127 57728 3797 89891 6991 57539 64792 9321 92104 11020 57560 83657 150737 83658 8655 200132 56912 51668 3842 255758 51626 112752 90410 23059 55112 22920 26146 28981 57576 79989 80173 9742 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants 5518 1452 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha 400569 9971 6907 9968 9969 8648 10891 2274 96764 9967 55090 123 23054 1543 23097 19 23179 2101 219541 8202 50486 80306 948 1581 1579 34 84246 3158 3157 6667 27242 10498 1024 1387 112950 116519 9443 405 406 9442 211 9440 85441 57491 80205 9439 6822 6604 9575 9572 2168 6837 4800 4801 4802 2033 6257 7376 51003 6256 23389 5465 4199 8800 10499 6095 51129 9477 29841 5468 3992 90390 9412 10025 10062 892 79718 26230 183 27063 54600 57761 55588 2180 9441 5244 8841 51586 4520 10001 196 4862 81857 9915 1374 25942 11010 84498 54797 1376 29079 2222 2874 7296 5469 133522 9282 6721 4899 376497 9862 335 9612 336 9611 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants 238 ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets 51231 2002 1849 1848 9252 1846 1845 5518 5594 5595 5519 1432 5515 5516 5600 6197 5528 6196 5598 6195 4205 4208 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma 1545 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions 8745 203190 10369 27092 53616 10368 1742 4185 6804 112755 9211 59283 163175 55203 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism 56922 3141 31 5095 64087 5096 686 5091 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation 9730 154214 151636 80176 23194 9604 136371 10324 10489 200845 8454 6233 7321 11065 8697 7324 10393 29945 29882 996 51343 51529 8881 64682 7316 84676 27338 80196 246184 51434 51433 11059 23291 7322 997 7334 7335 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 114907 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 991 5705 89122 9978 83737 54778 8452 8651 84078 23327 7428 6502 7323 6921 154881 7320 6923 23608 6478 7325 6477 131405 283807 221687 79654 26272 51088 9616 90678 7317 56658 7319 10533 3093 26234 22888 7332 64750 9870 6468 7336 10425 150726 64718 118424 23295 55336 7327 7326 9867 26190 197131 10273 7328 26270 4734 10422 54926 9520 65264 10193 10616 10075 142678 93611 127247 401036 79791 55294 55585 57520 51665 89910 7337 51666 55905 26091 63891 63893 142686 57531 142685 55236 51676 142689 223082 10517 22954 8453 91694 10293 9666 51320 84261 80204 57542 57154 51444 5930 11146 135892 55008 6047 6049 26224 23376 23014 9246 5071 54461 29116 57674 143279 57630 25793 84231 51191 11275 9320 55819 64410 90025 222235 84937 7318 140691 51465 54850 140456 140458 90933 140459 90135 25897 25898 9690 146330 140460 140461 140462 255488 114088 54620 23352 868 8916 115290 6737 7704 55958 8139 390594 127544 55284 27246 84961 8924 122769 8925 9021 64320 9354 81559 55175 84708 7174 27252 51130 642 51132 26046 9903 4591 25847 158506 92369 55182 126433 26259 64219 7064 23304 201456 80028 144699 899 84861 92912 10477 26268 55070 90293 84727 92591 26263 26267 53339 285231 89890 4012 9820 26235 26118 79176 26232 55521 84085 4008 9817 51725 9039 25831 26249 8065 55658 140739 51619 9040 148581 79876 79754 84541 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors 1816 1815 1814 1813 1812 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin 217 4128 6532 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 10238 10517 6774 26330 898 908 6950 84261 7203 9134 22948 63971 26985 26272 26224 54461 83752 10528 26234 8877 10693 10564 6468 10574 10694 10576 7157 2629 10575 26190 26270 22803 55294 55135 6499 8841 11328 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion 111 112 59345 783 2793 784 2792 2771 2791 2790 2770 2782 2788 2787 2786 2785 2784 2783 10681 51764 150 152 9254 94235 55970 775 776 54331 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency 2937 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 5928 8370 5931 2146 94239 23649 5422 993 994 995 11035 197259 2801 5557 5558 3013 1687 255626 7157 3021 3018 3017 54145 3725 3014 351 2309 84290 708 8331 8337 8334 8335 1020 823 824 474382 826 8772 8341 1029 7186 831 8342 8970 8347 7531 8348 128312 8345 356 8340 841 8737 55766 8717 8726 8968 5052 8338 8851 7001 1789 1788 1786 85236 8349 6648 653604 4001 23512 10018 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism 122970 3248 8644 8309 26061 58488 113612 401494 4594 22880 5444 59344 51144 81616 27306 84693 2877 283927 60481 2876 6785 1545 1543 91452 5445 2879 1558 1544 51495 5446 79071 55856 2053 240 1557 1559 215 9524 54677 9200 284486 1582 1580 23600 30 1579 33 1573 34 35 145482 37 9536 3295 3293 55289 47 873 51179 390916 79966 5467 64174 641371 2166 84129 79993 142827 51703 126410 109703458 6342 127281 4051 23305 4056 23597 84320 4048 166785 64834 54898 239 80221 10478 8529 4363 241 242 6256 246 247 3033 5096 158833 253017 51422 1622 31 1800 5095 10728 3992 9415 11332 9261 23205 1892 5538 10005 1632 197322 7069 80142 117145 6296 55825 2678 5563 5565 1666 2180 2687 51102 4706 11001 11000 55301 5730 1374 6584 158584 788 284541 5740 80724 5321 1384 10449 1962 5264 1376 27349 1375 201562 3032 3030 134526 58526 6319 79777 26027 57834 2194 5742 414149 5743 9374 7923 8310 376497 83401 11283 2182 84869 2181 22949 6916 26063 10965 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors 10369 27092 10368 815 816 817 818 4193 2891 5582 9463 7102 2892 2890 23426 4905 1739 5579 80852 2036 5578 2893 160 1742 9495 4646 59283 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors 134 135 140 136 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants 5156 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 5295 10818 5290 22916 4686 10253 8569 5430 5431 5432 5440 5433 5441 80004 5335 3178 54845 4670 3187 2251 23543 7073 6233 7072 5434 5725 5435 5437 5515 5516 2963 2962 5781 7316 5436 5438 2549 5439 9982 83888 2248 2255 2252 27006 143282 867 2247 3185 5518 7311 7314 673 5594 5595 4893 6654 2254 8074 2249 3265 2246 10817 8823 8817 26281 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 5436 6908 4331 5438 5439 902 129685 6872 404672 6874 2071 6873 138474 2068 6881 6880 5430 6883 5431 6882 5432 5440 8148 5433 5441 6884 2966 2965 51616 6875 6878 83860 5434 6877 54457 5435 5437 2959 2958 6879 2968 2957 2967 1022 2963 2962 2961 2960 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 5687 5688 5689 5700 5701 5702 5704 5705 999 3728 1508 1495 1514 1785 6233 27085 1500 79872 10399 2060 1520 7316 6714 4193 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 54971 5708 5709 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis 5058 147179 3708 3709 5295 5296 5290 5291 2268 3710 917 644150 3055 6850 2209 10006 26999 2534 2214 2212 5580 3326 10458 10451 7525 10787 25 7410 5335 4627 10109 10152 7409 3320 23191 71 5581 4650 4651 4771 4644 3984 196051 84513 695 4620 51517 4641 10552 10163 3071 5747 5336 8398 10093 9844 63916 10092 4067 1398 10095 8976 10094 1793 60 10097 5879 10096 10810 4690 10768 7454 7456 122618 55845 998 5594 5595 23646 1072 5337 8936 5338 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope 5266 3728 1829 5045 823 404203 4014 26239 826 6707 84648 353132 353131 6700 643414 11187 6701 6704 643418 6703 3713 6706 6705 643394 63036 353134 43847 23254 353133 43849 353135 64065 7051 353137 353139 26085 126638 199834 353141 2312 149018 1832 353140 353143 353142 1825 1824 1823 5046 6698 8502 353145 353144 1041 7062 448835 1830 2125 23581 1475 142910 6768 5317 11005 11202 1828 147409 5318 9333 5493 25818 5652 254910 6699 340654 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response 840 842 578 56616 1029 51074 836 55075 331 5594 5595 581 708 54205 1687 317 22900 57099 79792 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase 4843 3708 5152 5153 5136 2977 10846 4846 2983 27345 2982 10242 5138 4842 50940 27094 3778 3779 10335 8654 5593 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere 5436 5438 8341 8342 8970 5439 8347 8370 8348 128312 8345 94239 8340 55766 26277 1616 25913 65057 7013 3013 8338 7014 54386 546 5430 5431 255626 5432 5440 5433 5441 3021 85236 8349 3018 3017 54145 3014 5434 5435 5437 8331 8337 8334 8335 8290 474382 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling 3082 4233 5295 2549 5290 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function 2652 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint 23421 51143 401541 64105 378708 1780 79172 1783 83540 80152 8655 3619 7321 64946 1781 25906 11065 8697 7324 1778 10393 29945 348995 29882 996 57122 699 51529 8881 64682 27338 140735 119504 55746 246184 25936 9793 51434 51433 23332 6232 23279 79980 79023 54908 5347 22919 6396 5048 151246 9735 5905 5518 1062 5903 220134 57082 54820 5501 6249 79902 9212 25909 9183 54821 9184 991 23122 4085 701 81930 84643 55920 3796 57405 7514 10403 80776 11243 5519 5525 5515 5526 5516 5527 11004 5528 5529 91687 57551 79682 11130 332 2491 55839 8379 55143 55166 10726 79019 1063 1060 151648 1058 79003 55055 81565 147841 348235 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals 90249 137970 6714 219699 8633 5781 1630 9423 PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy 2034 7316 4077 5830 8878 84749 7311 7314 81631 472 6233 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism 2954 3081 3242 6898 2184 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction 64398 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants 2322 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 6208 25873 6223 6167 6222 84164 10973 6169 6188 6224 140801 6187 90850 23521 6160 6189 6161 6233 6218 7321 6217 6175 6176 6171 6170 7323 6173 7316 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 6235 7322 6227 6229 6228 3921 6122 6124 6123 116832 6125 7311 7314 6130 6133 6132 6135 2197 6134 6137 6136 140032 51121 4736 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs 22868 9238 60493 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 5687 5688 5689 5700 5701 5702 5704 5705 208 1460 1459 8975 207 6233 81847 1457 23252 5987 8658 80351 2444 7316 23608 5728 11060 80243 9861 5682 5683 5684 5685 5686 10273 5717 4734 5718 5719 7311 7314 331 11047 10213 5713 5714 7979 5690 5691 10000 5692 5693 5694 5695 5706 5707 5708 5709 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs 808 28964 10645 84254 8536 5879 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection 147179 3708 3709 718 3710 2771 7474 2770 10006 8324 1535 10458 10451 7525 25 79651 7410 10769 5335 9332 4627 4791 10109 4210 9051 29108 7409 4790 808 10910 23191 10628 5027 834 4651 4644 124056 4620 695 51517 4641 10552 5577 5970 3162 3071 3569 5336 2793 2792 2791 2790 10093 2788 10092 2787 2786 4067 10095 64174 8976 10094 2785 2784 60 10097 2783 51764 10096 10768 7454 7456 94235 998 5594 5595 55970 5566 79792 54331 59345 114548 57105 2268 917 644150 3055 6850 136 2782 2209 346562 1800 2781 10800 26999 2534 2214 6868 2212 3326 2773 10681 10787 5599 5045 1511 10152 3725 2678 1432 71 4650 5025 3552 3553 719 3606 2687 10163 111 112 113 114 115 5747 5613 9844 63916 196883 1398 1793 1855 5573 10811 5575 5576 5879 10810 2778 953 27035 107 108 4690 1857 5567 1856 4907 109 5568 957 7295 55845 3586 8936 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism 6489 5476 10020 54187 80896 7903 129807 2720 10610 81849 26503 338596 51046 6483 6482 6484 8128 4758 29906 10825 4759 6487 8869 6480 256435 27090 10559 30815 10402 140838 84620 55907 55808 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 29126 6774 639 2033 3091 25942 3066 3561 8841 3065 1786 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency 56922 64087 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) 9337 2033 8370 94239 27161 57472 3013 9125 9775 255626 29128 7157 3021 29883 25904 4850 1981 3018 3017 54145 3014 4848 4849 8331 10413 8337 8334 26986 8335 200424 5927 6732 55571 474382 8341 8342 8970 23405 8347 129563 8348 128312 5620 8345 201516 100288687 503835 5619 1975 8340 7004 1974 246175 1973 55766 342900 678 1977 8968 8106 390245 1387 7290 503627 55211 8338 100033411 54766 285051 79670 284355 23318 132243 10361 390748 359787 10605 7403 124512 57379 151871 85456 85236 8349 23019 10765 653604 23135 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 3768 2570 2569 55584 2567 2566 3773 8825 4900 4747 55879 9647 170572 2771 8573 2900 2743 2770 2742 2741 2906 2905 2902 2901 5582 285242 200959 9463 22843 7102 320 27330 2892 116443 2890 23426 1146 4905 1145 1739 57554 5579 1144 80852 2036 116444 9568 2893 27020 89832 9177 8001 2899 2898 2897 2774 5923 808 64130 5330 5331 57576 5924 59283 1138 1137 5577 1136 1135 1134 10369 8973 23236 27092 1143 1142 10368 1141 2793 2792 2791 4193 2790 2788 2787 2786 2785 2784 2783 51764 2904 2903 94235 53632 5594 5595 55970 5566 5170 54331 28964 59345 2891 51422 2782 346562 2773 10681 6197 6196 5562 6195 5564 5578 160 23229 5571 5563 10645 5565 84254 8536 4646 111 3084 112 113 114 814 115 815 816 5613 6714 817 818 196883 5573 5575 5576 5879 107 108 5567 109 5568 88 3760 3761 2550 3759 3359 55327 200909 3772 1742 2562 2561 2560 2559 2558 2557 2556 4893 83988 2555 1741 2554 1740 26960 3265 9495 3838 3762 3763 3765 3766 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development 4851 2033 8850 3280 208 1387 2255 3174 6928 3630 2645 6514 84441 9794 3516 55534 390874 256297 5080 207 6927 22938 50674 4821 4825 3170 4760 10000 2308 3651 2648 3375 3175 389692 3171 222546 10046 3642 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 5928 8341 8342 8970 8347 8370 8348 128312 5931 8345 2146 94239 8340 23649 5422 55766 8726 8968 5557 5558 3013 1687 8338 1789 1788 1786 255626 3021 85236 8349 3018 3017 54145 3014 653604 8331 8337 8334 8335 474382 23512 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium 89891 6991 64792 9321 92104 11020 57560 83657 150737 83658 9662 8655 200132 7840 56912 51668 11064 255758 1781 51626 3320 112752 22994 90410 22995 23059 7283 55112 26146 1778 28981 10733 80321 57576 203068 79989 55722 80173 6753 1454 5147 1453 27241 55125 5310 5577 5311 9814 261734 140735 9738 55212 117177 11190 51134 403 9793 10013 51259 7532 54806 7531 10383 4735 10382 6010 6950 7203 23332 23265 92482 115106 84902 79441 95681 84747 378 1069 60412 84100 54536 5347 22919 4867 54801 2847 10142 9657 7846 91147 27077 9702 10540 85302 10640 5108 4218 11336 129880 11116 149371 4751 347240 5048 1262 1260 55142 22832 10694 22897 57787 54930 57545 10576 1258 123016 10575 5116 79959 55763 79738 80184 8729 5518 93323 26005 166379 7277 55770 79600 26123 79969 50807 23354 22981 8195 132320 8481 80254 6102 8766 983 146057 121441 55755 582 54820 583 10806 54585 22920 585 10121 27031 5566 79867 192668 55835 9727 55559 8636 11258 84131 4957 9371 200894 22948 3797 80776 3842 56623 9742 23322 55081 55764 79659 8100 51098 79598 79809 26160 6608 11127 57728 57539 54903 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes 1387 2033 4780 7975 468 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling 4915 4908 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6157 6156 6159 6158 200916 7415 6164 6166 9045 6165 6168 6167 6169 23521 6160 6161 6233 7321 6175 6176 6171 6170 6173 7316 6921 6181 6923 7322 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 7353 5708 22980 5709 9147 23008 55139 5687 55666 5688 5689 8453 5700 5701 5702 5704 5705 11224 25873 140801 25898 9349 9978 26046 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 6137 6136 51121 4736 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 55788 1504 4552 51293 4363 26119 4594 27249 6948 81693 5826 6947 8029 25974 5644 4548 4036 326625 166785 440387 2694 5646 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members 650 409 4613 23327 4343 192669 23112 27327 26523 27161 192670 57690 7040 5590 5494 25937 6233 8812 7321 7323 5933 7316 6498 6667 6497 5054 4086 4087 5500 4088 4089 1024 142 64750 4091 4092 10273 51592 1025 7311 7314 5499 7046 7048 5594 7050 5595 5501 4904 904 1875 905 4052 7043 4053 4054 2033 5664 50848 60436 5663 130399 2280 3726 7042 57530 56937 6256 56288 91 57154 92 93 94 4323 8928 8425 9110 9350 4617 4325 4738 4618 51377 55851 4221 83464 9765 9241 657 658 5914 659 11167 6925 11171 268 269 7514 91851 1874 4090 23645 23370 4093 5045 3693 3694 3685 4654 892 4656 10468 3690 10589 25805 10272 27302 22938 83855 23385 7027 3696 9958 51107 10755 3070 7049 7077 64388 2658 7076 3625 3624 3623 7029 6929 8239 408 6938 387 867 2247 1030 3065 1278 54778 23439 8516 3688 9612 9040 9611 50855 4609 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins 11164 56985 55270 131870 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors 27198 8843 338442 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 4869 4605 3329 4839 7020 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily 5928 57504 7341 8370 5931 94239 9219 1107 9112 3013 7329 1108 8932 255626 3021 54815 3018 3017 54145 3014 53615 8331 8337 8334 8335 8099 26038 114825 474382 125997 2203 55205 6941 22806 22807 8341 57592 11335 8342 23613 8970 8347 10263 8348 170394 128312 8345 9640 7026 22850 85509 10951 8340 23394 10320 55766 152485 84295 8968 8338 2538 85236 8349 5105 3066 3065 653604 7182 57459 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 1544 8529 1557 1559 1545 113612 1543 1579 1558 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) 56606 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression 6908 57678 8648 94239 4343 192669 23112 27327 26523 27161 192670 57690 595 861 5430 865 5431 5432 200845 5433 8202 54145 3320 2958 2957 8331 8337 8334 8335 2963 2962 5436 5438 8341 8342 5439 6667 8347 8348 8345 8340 7528 10498 1387 5451 8338 10524 2494 2353 7039 4602 85236 1025 8349 1386 23028 7090 904 596 2033 8370 5241 2099 10499 10728 3013 3326 255626 1509 5440 5441 3021 3018 3017 3725 3014 5434 5435 8312 5437 474382 8970 8850 128312 55766 51523 9126 8968 2288 8204 4435 6387 7764 10735 2625 3727 3169 2354 9166 9687 23189 10274 7033 8243 7392 7391 5469 7031 5885 3276 23030 3065 653604 3838 1655 4609 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants 4893 3265 3845 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 3032 3030 33 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling 5295 7010 5296 9046 6464 5290 284 2886 5291 285 2888 51378 4893 6654 3265 5781 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors 9337 23405 1975 1974 246175 1973 678 1977 27161 57472 54766 9125 9775 390748 10605 29883 85456 25904 4850 1981 23019 4848 4849 26986 55571 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 7534 7532 7531 11200 7533 890 8900 10971 7529 983 1111 2810 995 7465 891 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 29844 10714 54891 86 4331 79913 51426 7341 50813 5424 54617 57804 902 10038 10445 2067 404672 10920 1642 8554 283899 83444 5886 4798 5887 54107 6612 7507 7508 7329 6613 10401 2873 8607 2966 2965 6233 1643 2968 2967 1022 9318 6117 7316 5111 6119 6118 9978 2071 1069 7528 2068 142 60 7334 7336 5982 5983 7311 7314 8451 5981 54778 8533 8450 2073 2072 64708 56655 5984 3978 85015 5985 7515 9557 125476 10987 51138 5425 5426 10980 5427 93973 3980 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance 1175 160 338 161 26119 163 1213 1211 3949 8435 23491 57552 51599 4864 6646 255738 3988 10577 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events 1135 1134 8973 1143 55584 89832 1142 1141 1146 1138 1145 1137 1136 1144 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation 5594 5595 6654 6464 8660 3630 2887 3643 3667 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria 4836 637 841 3002 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling 3460 9021 5777 7341 3717 8651 3716 3458 5770 8554 5781 3459 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism 8611 130367 8612 125981 55331 340485 8879 221 81537 222 8613 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs 6128 6129 22794 6201 6142 6203 6202 6141 6144 22916 6143 6146 9939 6147 8861 6139 4686 6138 6152 6155 65109 6154 6210 6157 6156 9775 6159 6158 51065 200916 6205 10921 6164 6204 9355 6166 9045 6207 8022 6165 6206 23053 55110 6209 23708 6168 6208 6091 4116 6223 26019 6167 6222 56956 3670 6169 6224 23032 23521 2107 6160 89884 6161 65110 4440 6233 6585 6218 3199 6217 6175 1287 2935 6176 6171 6170 6173 7316 6921 6181 6923 6230 6232 6231 6234 6235 6227 6229 6228 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 8453 5700 5701 5702 5704 5705 11224 25873 6188 140801 6187 6189 1981 26986 9349 6191 6193 6192 6194 9978 6092 3921 6122 6124 6123 116832 9353 6125 6130 6133 6132 1605 6135 6134 2197 6137 6136 51121 140032 4736 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 5929 6907 9968 57678 9969 8648 10891 5925 94239 9070 729359 123 23054 60481 10555 22976 25 5166 8202 54145 948 58508 8331 8337 8334 8335 84962 1020 84246 8341 8342 8347 8348 8345 8340 79447 1024 1387 8338 9443 9442 2494 9440 85236 8349 9439 22822 1050 2033 8370 51003 6256 8800 10499 51129 9477 3013 90390 10025 255626 7069 3021 63924 892 3018 3017 2167 3014 57104 79718 11343 2180 8841 474382 9370 10001 23175 8970 128312 55766 79611 8968 4023 23411 29079 2874 5346 7403 5469 6319 133522 9282 653604 84661 9862 84649 11091 9612 3991 9611 8085 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants 3815 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6201 6203 6202 6210 51065 6205 6204 6207 6206 6209 6208 6223 6222 6188 6224 6187 6189 1981 6233 6218 6217 1978 8662 8663 8661 8666 8667 26986 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6191 6193 6192 6194 6230 6232 6231 6234 1975 6235 1974 1973 6227 6229 1977 6228 1965 8894 1968 3921 2197 140032 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing 4913 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events 2767 111 112 23236 156 113 3708 114 5137 814 3709 115 5153 815 5136 5613 816 817 2769 818 3710 5321 196883 2776 5582 5580 5573 5575 5576 107 108 5567 5578 10768 109 5568 9630 808 5594 5330 10645 5331 84254 5332 5566 3838 26960 5577 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus 51447 9807 64768 253430 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane 55300 55361 22876 30849 5289 55697 8898 9110 54893 5286 200576 9896 4534 54545 3631 8821 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin 7450 2157 2147 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling 3084 2064 2886 9542 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation 5034 3914 3918 1299 1298 91522 1508 649 1514 80781 1287 1515 1520 84570 50509 8974 10491 7373 256076 9313 23127 136227 10536 7093 81578 7092 871 283208 5339 1305 7837 1303 5351 3691 5352 5033 8985 1308 1302 1307 1301 1306 1300 55214 4015 4016 4017 64175 1310 1286 26577 140766 1285 1284 1282 9508 169044 9509 1281 1280 255631 57642 4322 977 1297 5479 3655 5118 340267 3909 84171 1278 131873 1277 1296 1295 1294 1293 4314 1292 4316 1291 1290 4318 1289 1288 85301 84695 79709 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy 95 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle 8500 10815 6854 6853 6844 6616 5864 10497 9256 6857 8825 55327 8573 64130 320 6571 6804 8541 8497 22999 8224 8499 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 808 814 5566 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex 5977 57492 86 26039 8193 6602 6605 6760 60 6595 9274 605 9275 8289 6597 8110 6599 6598 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) 7316 55741 6400 9695 6048 7311 91445 7314 80267 10206 56886 10956 6233 267 84447 7844 10299 55757 11236 51009 11253 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation 6657 6932 51592 1499 8928 4087 4088 4089 8320 6862 145258 387332 79923 5460 83881 652 51176 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome 411 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling 5928 5295 5296 10818 5290 5291 3667 4343 192669 23112 27327 26523 27161 192670 57690 3643 5156 1950 5305 2064 1956 2251 6233 79837 7409 8649 7316 10542 253260 389541 28956 4193 57521 11060 6009 4915 627 9861 5682 5683 7039 5684 5685 5686 5717 5518 5718 5719 55004 7311 7314 11047 10213 5713 3654 5714 1026 7979 2475 1386 5690 5594 5691 5595 5692 5693 58528 5694 5170 2254 5695 8074 5706 2249 5707 2246 5708 8823 5709 8817 572 26281 842 5687 5688 5689 5700 5701 5702 79109 5704 5705 391 23396 2534 55615 3630 6591 5155 118788 51135 2323 4615 930 5159 6801 23035 84335 940 941 2322 942 1822 84232 1958 2264 23239 64223 6615 7874 6199 8975 207 81847 50852 23252 90865 5987 2931 8870 8658 9965 80351 57167 2444 152831 9173 9846 57761 255324 5781 64121 6446 10670 5371 153129 10325 80243 7189 10000 5978 8660 3932 57504 5294 3164 5931 5293 1107 208 1108 54815 53615 8535 3082 51564 4233 7101 2549 23533 374 10014 6045 23608 648 6015 23466 1912 2248 1911 2255 2252 27006 80012 57332 8396 84733 8394 8395 7249 8503 10273 4734 331 3815 4916 2932 4908 23028 57459 146850 2146 2099 9219 9112 5468 1147 7157 1460 1459 117145 3725 1457 2309 5519 2308 23186 5525 5515 5526 5516 5527 5528 5529 8841 9542 3084 6714 5880 2069 5728 1027 685 2100 8726 10718 1839 5879 145957 2247 2122 3066 3065 4303 23512 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis 3659 578 27243 11035 5071 197259 128866 10015 1687 10211 3002 7157 3146 79643 51652 57162 6233 1991 3320 834 837 838 6386 3552 3553 3606 11140 29082 7316 8772 7186 8795 836 8743 8797 91782 8626 355 25978 356 83737 841 8737 8717 92421 581 54205 7332 8473 10273 7311 330 7314 331 329 2319 3660 79792 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 59345 9138 388 389 9181 27237 23365 6655 2782 128272 11214 121512 10681 1894 10451 23370 25791 7410 23229 50649 50650 9826 9828 7409 22899 26230 5364 6453 8997 8874 10276 55701 100271715 6915 695 54848 5924 2768 389337 445328 9459 10672 146 147 84904 148 26084 4168 2793 2792 2791 2790 55160 2788 2787 2786 2245 57580 2785 7204 2784 2783 51764 6093 57449 7074 387 9475 94235 29 55970 64857 89846 6654 23263 221472 9639 7984 54331 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease 5928 5929 9968 9969 894 896 902 5925 3280 4057 6279 6280 7097 7096 1191 920 23493 9861 23462 5682 5683 5684 7039 5685 5686 28514 2811 5717 3516 5718 5719 1499 11047 10213 5713 5714 7057 7979 7291 3955 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 4851 5687 5688 5689 5700 5701 3726 5702 5704 5705 64087 5096 686 5091 56922 3141 31 5095 60482 3312 7514 7534 8021 1981 207 7529 1994 1432 3549 26986 54464 3304 111 112 113 114 115 1452 9978 83737 196883 5573 5575 5576 2778 107 108 5567 109 5568 10559 6886 11041 9215 55624 1605 8452 4893 4763 3265 399473 161742 200734 3164 718 129685 6872 22916 6874 6873 23327 2547 27243 55048 23165 4686 128866 89853 10015 6749 9631 7175 6881 7525 6880 5430 6883 5431 6882 5432 8148 5433 6884 7852 6917 79643 1104 51652 51497 11198 6875 6878 83860 8812 6877 51534 2959 2958 6879 8815 2957 348995 9883 9525 57122 2963 2962 2961 1234 2960 29082 29959 5436 55746 6921 5438 6924 137492 5439 6923 27183 91782 23279 25978 79023 51271 7469 138474 4087 10762 4088 8178 4089 92421 6396 8732 142 7520 129401 8731 51160 6829 3836 4927 3159 7518 155382 6827 9397 93343 9150 7251 5905 79720 2237 1025 5901 5902 51616 5903 3981 9688 23225 25920 54457 51224 7936 55706 3978 23636 9972 11097 23511 8086 53371 8480 79902 51510 904 4904 905 4836 1462 2990 3373 3074 3073 3425 411 2720 3423 633 1463 10675 9246 64135 3551 23586 25820 51191 9451 1147 8517 9636 7318 3309 7706 6456 1175 2153 160 161 2147 163 710 2266 3690 1213 1211 2243 8312 2161 5519 2160 324 2159 5525 2158 5515 2157 5526 5516 5527 5624 5528 5627 139285 5529 11140 2244 55914 2812 2815 5245 2814 5610 5613 145173 57188 2591 143662 10417 118430 10418 170689 171019 54437 9037 4582 5199 4583 4584 7058 4585 4586 200958 157869 29954 727897 29071 140766 80070 2247 10585 9508 9509 10071 94025 339366 221981 140453 79875 182 81794 4588 55901 4589 81792 283463 9719 56913 394263 11173 11174 80731 54507 92949 170691 3688 5611 3843 2926 10635 675 4609 3718 7516 238 5777 5295 5296 10818 79728 5290 5291 246213 3437 3434 3667 3433 11267 4343 51028 192669 84313 26523 27161 1185 192670 57690 595 861 476 7040 3845 477 478 53822 53826 53828 7321 4790 480 25906 11065 481 8697 7324 482 10393 483 29945 486 29882 996 51343 51529 8881 64682 5970 27338 119504 1051 246184 1029 3569 51434 51433 6934 6230 6232 6231 6234 64398 6235 63982 253832 6227 6229 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 7335 64601 79760 6480 10427 256435 27090 9868 9641 11282 8678 5289 3661 29801 85437 81631 51304 3654 55107 5348 3656 5349 91662 6383 10082 6385 7113 59272 22863 5170 6382 143 5894 58505 2697 51311 79668 821 3665 27072 3442 3441 3440 23367 114548 3439 2280 2589 51201 54956 57105 100128731 2268 55129 917 3055 10971 10610 6850 221914 136 9672 2209 3452 346562 3451 2781 10800 2239 2534 3449 3448 2214 2212 29110 3326 2773 611 3446 3445 26762 3444 54960 51135 3443 89122 4615 10392 84818 3456 3454 3146 55823 857 6607 8487 6185 6188 6187 4793 6189 2262 23479 6184 23118 121601 2931 2810 3107 54106 3106 3105 6733 11253 746 54625 51114 6732 2817 255324 5648 1603 5781 6632 10053 7841 203859 6191 6193 6192 7284 6194 8546 57101 26276 51125 162 51128 164 65082 84282 6628 7297 23339 6885 408 338440 3134 3133 9908 9685 6634 6633 2719 8907 6636 6635 8905 10146 5878 3921 6637 2804 7187 7189 84061 130340 6773 6772 80143 55741 1174 79833 3135 11320 8829 653509 7991 6440 92359 340061 729238 4245 6439 4124 1439 3276 1438 11218 10802 56965 201595 10484 10000 3703 50628 2197 7082 23765 3716 8660 140032 3838 1655 51284 1650 4247 4249 10454 50636 6441 6201 30849 6203 6202 7533 64127 409 7855 26007 25834 567 83666 8322 196527 84875 7474 8325 79844 5589 8323 57719 8324 208 11311 375790 7405 3605 6210 112744 4153 25929 25921 51065 7415 6205 6204 6207 6206 6209 6208 6223 9321 6222 7555 6224 257397 23193 10207 2530 7428 6218 6217 57617 808 112755 2793 2792 2791 2790 2788 2787 2786 7317 2785 2784 10533 2783 51764 94235 55970 55236 54331 59345 898 9134 2782 57674 10681 54657 2582 3938 6476 84441 9794 6400 2683 55534 4853 4854 4855 1869 3725 22938 7027 1871 23352 7029 10046 283652 9542 3084 1019 1017 2069 1027 685 9844 63916 1398 10718 1793 1839 5879 6421 867 145957 2194 4008 9817 9039 8065 79876 9785 6430 6432 6431 10250 51362 199746 6427 6426 23649 5422 6429 993 6428 994 11035 197259 2801 10189 5557 5558 1687 8683 9775 9295 10921 11338 5156 7307 215 3178 54845 4670 3187 2251 5725 1500 79872 2060 4651 4644 4620 4641 7099 929 8772 7186 23643 148022 356 841 8737 8717 7322 4067 4792 4915 8851 627 2646 2645 7046 7048 673 5906 5594 5595 5604 5605 6654 2254 8074 2249 2246 10817 8823 8817 26281 79792 10568 842 6569 142680 5034 4969 546 2652 2799 8878 2322 140801 5826 2331 2328 5987 8658 80351 5025 55588 3552 3553 719 3606 10020 81857 1974 1973 1977 8106 5868 4552 8908 4548 51121 3251 4594 5443 54658 23521 4128 4143 5476 23533 8976 51181 55763 8503 8729 4166 5499 229 326625 4908 7353 55666 5664 55851 83464 5053 9412 130589 9420 51107 9441 291 51586 7276 10951 56606 26503 2288 10166 9469 23189 83990 7296 7295 6464 400569 3708 3709 113612 3710 3712 55090 1545 23097 3002 3459 11081 3460 9045 1583 9061 9060 5950 1594 1593 4913 1591 8974 1589 1588 1586 79644 1585 1584 283208 3767 5033 5947 64174 57407 6804 10768 126410 5479 3795 5501 6833 5507 6837 6844 4669 6857 6048 91445 2023 10956 84447 51009 10728 5155 118788 2323 930 5159 6801 11224 84335 940 25873 941 942 2264 6199 50852 5549 9965 152831 9846 837 2305 4968 6888 5824 1479 1478 1477 55109 2342 2339 2335 1488 1487 10613 27044 1028 57794 5869 317649 127833 145226 1052 11100 10256 10262 54797 90701 56829 113189 85365 123041 10236 53335 5593 79947 4131 23524 115004 57703 4140 51293 684 689 9843 5002 51185 5495 4158 4170 5037 64840 79087 138050 51530 1901 10195 23020 85313 11045 11044 9879 335 9410 11052 9899 11051 9416 6448 10181 9444 51585 2803 26508 23476 23478 5093 5094 51593 199857 54623 84844 83999 26154 1982 1993 50616 1524 1523 23169 8175 79053 3714 8189 26127 2885 51503 353 27436 8647 399687 23601 9076 55690 55696 5959 5956 19 3791 79661 283455 55247 712 716 388585 721 722 91319 725 57448 6843 4666 4691 11221 5551 56949 9900 375 5546 7750 55630 115361 10332 10333 10342 7301 6455 5119 10313 5133 54344 6457 51639 38 23168 163351 23164 6469 51645 6005 9990 368 369 21 11160 24 8671 8672 9532 10295 9530 5172 6017 9526 10291 10294 51692 11123 2923 116150 10280 10283 25777 8241 51234 10286 10285 27121 79139 27123 9111 2956 29760 1639 9148 1660 56052 60559 1654 3839 9152 1665 84991 3840 3841 2521 81030 81031 2937 81608 22872 9187 10898 30011 55339 10421 146850 54492 79796 80304 811 26275 22866 57534 81622 95 285755 22845 120227 2120 22808 22826 22827 92579 6993 3480 6521 55733 54883 4351 6531 6530 54894 6524 6523 11325 55749 1629 4360 64220 64225 30061 3040 54431 10450 64241 64240 6566 6557 10461 6559 10465 11314 6575 7414 91869 54463 3069 6578 53938 28972 23283 3837 3092 440400 24148 7448 2998 9646 8315 2997 57085 2992 5292 9648 53981 222236 51340 9208 57461 27248 10827 50846 116085 27238 29894 2621 51726 51729 7094 2634 2633 402569 80273 1798 29851 30835 26229 79412 2677 926 928 114609 1356 10992 22987 10525 10527 945 10523 4891 10978 2538 3554 57670 3570 81793 973 974 2548 22943 2263 2261 2260 3587 2542 988 4437 5782 440138 6629 54518 8805 220988 23450 8813 6638 8818 10594 4000 6916 91937 550 551 552 553 4736 554 22856 558 8844 5356 378884 80824 54567 79849 3417 3188 3184 9715 9716 3192 4040 3191 4041 3190 2584 5373 79868 8896 597 4061 6238 51411 1244 29929 7100 4072 10084 9789 4758 6271 1811 8449 10058 10060 23350 9343 2592 8496 56259 1852 1850 22924 80349 2588 10945 10946 10949 57599 6948 8036 10907 9360 10914 1870 80306 50507 9382 27339 4939 8087 83443 2132 2131 340665 162417 6520 6513 6514 126792 6528 25974 56603 435 5230 445 5244 55788 5236 6584 471 6122 6124 6123 6125 3098 6130 6133 6132 6135 6134 11285 6137 6136 6128 6129 5294 6142 6141 6144 6143 6146 6147 5293 6139 6138 6152 6155 6154 6157 6156 6159 6158 6164 6166 6165 6168 6167 6169 6160 6161 6175 6176 6171 6170 6173 6181 9227 27249 1738 112950 166785 2632 1312 4860 2678 2694 2687 5728 152926 2232 2230 953 957 116832 22934 22937 28234 10965 6616 7957 200916 219541 8826 10599 549 3162 6667 5336 100 593 594 4060 23389 1800 26873 8460 8459 1836 9349 191 81693 8029 7172 4907 2729 112812 2730 2771 2770 3615 3614 4958 4791 4210 9051 29108 351 10910 10628 5027 834 6502 833 3082 5908 4233 2549 374 4780 1938 1937 1915 2248 2255 2252 27006 89780 7249 998 23028 10362 51317 3043 3717 3831 3799 23186 1794 5890 5889 2984 9146 51606 11151 7879 4843 3181 3185 5062 6627 6648 4001 3586 4478 340024 6505 54716 6507 9056 153201 11254 11136 6519 1849 1848 79651 10769 9332 4627 4292 472 144715 5810 5932 5395 11073 6117 6119 6118 253260 4193 57521 4869 5052 10524 7486 7001 5982 5983 84126 1026 2475 5984 5985 5883 5884 116028 7156 5892 4683 79109 4436 3364 995 1616 641 55615 10111 4361 64223 1763 545 80010 672 9156 83695 5371 580 7098 83933 5978 317772 85235 55869 25855 221613 92815 8969 440689 5926 80853 23443 292 293 55343 10999 7355 9197 55315 6093 27316 56667 3815 4916 10479 285195 7450 11093 7341 2099 2908 9759 7329 10787 1892 5478 7157 1373 5009 383 1460 1459 1457 708 4650 57551 6711 5747 6714 5880 613 27035 4690 55750 10134 55845 10254 8936 1080 147179 51143 10006 10458 10451 1950 7410 5335 2064 1956 10109 8454 8655 6233 7409 1781 3320 1778 124056 203068 3183 695 7535 10552 5577 140735 7316 3071 7431 7532 7531 79869 5500 10093 4296 10092 10142 10095 10094 10097 11116 10096 4751 891 8945 5518 7454 7456 7311 7314 6500 5566 6249 572 10018 598 6774 5663 391 644150 999 26999 6868 9510 9507 5045 1514 1634 10152 1511 3818 23385 84290 71 170690 823 824 826 170692 10163 831 682 63827 1855 10811 10810 176 3339 56999 11096 1857 11095 1856 9475 8027 102 7170 7171 4318 9862 3932 6908 6907 57504 22906 5931 404672 94239 9070 1107 1780 1535 1108 25 1783 11168 54815 54145 23191 948 53615 1445 8331 8337 8334 8335 1022 51517 1020 84246 51564 8341 10013 8342 10014 8347 8348 8345 79885 8340 79685 3662 1024 1387 60 8338 9734 9443 6777 9442 6776 9440 2673 85236 8349 10155 9439 142678 10284 64426 79577 2932 57459 123169 4331 2033 8370 51003 2146 9219 9477 9112 3013 90390 8819 23451 10025 255626 5440 2002 5599 5441 5609 3021 6416 2966 5601 892 2965 3018 3017 3014 5434 5435 5437 2309 79718 2308 2968 2967 8841 474382 10001 814 8970 815 816 8850 128312 817 818 25942 2071 2100 55766 2068 8726 8968 1021 29079 1789 1788 1786 2874 3674 5469 3676 9282 3066 3065 653604 4303 51742 84661 2648 5888 11091 9612 9611 23512 8085 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery 6201 6203 6202 6210 25929 54960 51065 6205 6204 6207 6206 6209 6208 6607 6223 8487 6222 6188 6224 6187 6189 6233 6218 6217 6632 6191 6193 6192 6194 6230 6232 6231 6234 6628 6235 6227 6229 6228 6634 6633 6636 6635 3921 6637 79760 79833 11218 50628 2197 140032 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI 1040 57605 10423 9600 83394 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 11001 122970 10005 3295 1962 215 26063 30 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 6772 6801 3791 2803 6774 5295 5156 5296 2120 5290 57599 5291 51411 4893 6654 81608 3265 23189 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis 5478 PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 2247 5295 2549 10818 5290 2251 2248 2255 27006 2254 8074 2249 2246 5781 26281 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor 30849 5295 537 5296 10818 5290 5291 3667 208 3630 2887 3643 2323 1509 2322 155066 9114 2264 2251 117145 9965 54106 152831 5140 9846 5792 3416 57761 523 525 526 527 528 5781 529 2549 127124 23545 51382 533 534 535 50617 2248 2255 2252 27006 5770 51606 245972 245973 2247 5289 6464 9550 5594 8992 5595 90423 4893 6654 2254 10312 5170 8074 8660 2249 3265 2246 9296 8823 8817 26281 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis 2524 2523 28 CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly 808 837 1992 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis 54659 10062 7376 6257 8648 6256 9612 2172 9611 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs 51585 1479 29894 1478 1477 22916 79869 10914 23283 8106 4686 8189 81608 51692 53981 10898 11051 10978 55339 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins 1594 1592 1591 120227 56603 340665 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation 5578 5582 6810 6814 5579 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 7316 29126 5687 5688 1019 5689 7532 5700 5701 5702 5704 9978 5705 595 9861 5682 5683 5684 5685 5686 5717 1460 5718 5719 7311 7314 11047 1459 10213 5713 6233 1457 5714 7979 5690 5691 8452 5692 5693 5694 5695 5706 8405 5707 5708 5709 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins 7450 5908 3674 5747 6714 7094 2266 3690 2335 9564 2243 54518 5906 1398 2244 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS 6440 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis 1213 1211 AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport 59345 4284 360 375318 361 362 363 364 282679 343 366 358 2782 359 89872 10681 4645 22841 5577 111 112 113 114 115 2793 2792 2791 2790 2788 2787 2786 196883 2785 2784 5573 2783 5575 51764 5576 2778 107 108 5567 109 5568 94235 8766 55970 5566 551 554 54331 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters 10723 6558 6557 6559 9990 57468 6560 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD 5443 4158 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus 54492 7316 4851 113878 54567 23220 92737 8788 57534 5664 1272 5663 1840 409 83737 408 3714 55851 6868 83464 28514 7311 182 102 7314 9148 142678 6233 23385 51107 8650 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation 84545 85476 5018 78988 122704 92259 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 51073 118487 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 7284 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 54998 10573 11222 128308 51649 9553 64960 63875 64963 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 10102 56945 28998 64975 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA 7316 5687 5688 5689 5700 5701 5702 5704 5705 3315 9861 3312 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 1981 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 26986 5695 3304 5706 5707 5708 5709 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 5111 7316 6119 6118 7311 7314 6233 5981 5984 5985 5980 10459 5982 51455 5983 6117 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 4481 1284 286133 1282 7184 1281 117156 811 81035 78989 338 348 1278 2512 1277 2495 335 5648 8685 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System 7039 5617 1950 2255 374 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 842 84335 7249 23608 1027 4193 207 1026 2931 10000 208 2932 1147 572 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib 3320 2064 11140 55914 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection 8815 11168 3159 5478 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 6692 3249 4485 4486 10653 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly 57128 4519 54902 790955 7385 55245 7384 440567 7386 3313 90624 617 7388 7381 1537 10975 27089 150274 2395 29796 440957 728568 84300 3954 SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer 145957 3084 5295 1950 2549 5335 2064 6464 2069 1956 5290 5782 685 3320 10718 4893 6654 1839 3265 9542 11140 55914 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria 578 581 56616 54205 1687 79792 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade 7450 2155 2153 2152 2147 2262 221914 9672 6383 10082 2239 6385 2159 375790 2158 2157 2719 6382 3339 2817 5627 462 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis 3659 578 836 91782 8626 25978 27243 92421 581 128866 54205 1687 3002 7157 3146 79643 51652 1991 834 837 838 3552 3553 3660 3606 79792 29082 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 8992 427 523 9114 9550 533 526 527 528 51606 529 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 54623 7415 255626 80349 92305 3018 6596 3017 9781 6233 56852 7321 51322 5591 5195 5192 5193 7324 5194 3105 5828 7323 51255 9646 257218 55829 9810 220441 7316 5111 23168 8341 8342 8970 8347 7320 8348 8345 10670 8340 7322 7319 7332 7334 8915 7336 56254 118424 79139 85236 7311 7314 79577 123169 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion 11185 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 23708 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 2107 6160 6189 6161 51504 6233 6218 6217 6175 2935 6176 6171 6170 6173 327 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 6235 6227 6229 6228 29104 3921 6122 6124 6123 116832 6125 7311 6130 6133 6132 6135 2197 6134 6137 6136 140032 51121 4736 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling 2686 79017 2678 494143 2729 124975 55748 79094 2937 26873 2687 2730 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria 51181 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling 3718 6772 6774 3716 3578 3561 6777 3581 6776 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation 4072 11045 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation 2254 2246 8817 26281 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism 10568 6441 653509 6440 729238 6439 1439 21 1438 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression 4520 1465 6620 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome 5925 85437 1655 7428 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 51072 145957 3084 1950 1729 2064 2069 1956 685 10718 1839 9542 387 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer 5295 1950 2549 5335 6464 1956 5290 3320 4893 6654 3265 11140 867 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 6844 9900 22987 9899 6843 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) 4891 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA 6431 5356 9984 10250 22794 29107 3188 57187 3184 51362 199746 9716 7919 3192 84324 84248 3191 6427 84321 3190 6426 9939 8896 6429 10212 6428 728343 9877 51213 10189 84271 6434 10084 65109 80145 26097 8563 8683 8449 9775 10482 23350 9295 9343 10569 10921 56259 11338 2733 55110 79228 4116 7307 10946 3178 4670 3187 10907 9360 10914 6233 5725 27339 83443 3183 7316 79869 5500 7311 7314 85437 3312 8021 6632 11066 10772 11193 24144 8899 1479 64852 1478 55100 1477 143884 51428 10081 23398 3550 9092 6628 22985 55234 55599 8559 57794 58509 1977 6936 8106 59286 79576 6634 56339 6633 58517 51690 6636 51691 10262 6635 11157 8233 64895 6637 151903 10713 10236 5511 55702 5514 5411 23524 153527 60625 57703 84811 55954 11017 9584 6631 9589 154007 10929 6625 6626 135295 27258 84950 9128 9129 26017 23020 10915 85313 7737 63932 9130 9879 4236 9410 79706 57819 84081 1655 11051 25949 9416 7884 10181 79171 4809 51585 91603 1659 23658 55094 27336 5093 79165 5094 26121 51593 163859 25804 57721 22916 84844 79753 55660 7536 51747 23759 79622 51634 23165 51759 4686 8175 8189 9631 7175 51503 5430 5431 55696 5432 5433 56949 5546 348995 9883 57122 2963 2962 5436 55746 51639 10179 5438 5439 51645 23279 79023 10762 6396 129401 10291 51692 4927 10283 8241 10286 10285 27316 5903 5499 22803 1660 9688 23225 1665 55706 10284 84991 23636 2521 9972 11097 23511 81608 8086 53371 8480 10898 79902 55339 4904 22826 5930 22827 54883 11325 55749 23451 10450 5440 5441 10465 53938 22938 5434 5435 23283 5437 24148 53981 51340 57461 27238 29894 51729 10992 10523 10978 3181 3185 988 6627 6629 220988 23450 6638 10594 23517 9785 6430 6432 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 51094 5563 51085 5565 6794 79602 9370 51422 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 10071 94025 140453 143662 4588 118430 4589 56667 283463 394263 4582 4583 4584 4585 4586 200958 727897 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking 22878 208 22879 79090 221960 79890 84958 57589 2665 80006 2664 57465 23163 51762 23682 83874 10890 11345 8408 729873 10260 6764 9230 9909 84315 51256 160518 27095 163259 126432 9363 81876 26130 3257 27342 6305 79958 9135 201627 338382 125058 163486 382 54662 201475 51399 55357 1122 57533 10133 117177 7109 11337 6399 5861 11021 7531 51560 1121 79735 25782 57706 5872 5873 11031 126003 58485 23258 79961 51693 26000 116442 26088 60684 122553 4218 23011 10981 5866 84079 9827 374403 22930 22931 22898 54453 23062 7248 55667 7249 27147 83696 5874 54734 51622 83452 4943 259173 81631 89781 23637 9610 64786 8766 414918 51112 128637 5864 81846 51209 51552 5870 207 57679 5869 5878 5867 7879 5868 10000 9367 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation 6119 3320 1915 6118 3297 3281 10728 10013 7531 3326 7415 6117 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly 3691 667 1308 977 3914 3655 3918 3909 5339 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway 80086 6904 1155 7277 113457 10383 347733 6903 10382 51807 7278 7280 10381 6905 79861 112714 81027 7846 402 84790 10376 84617 6902 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 5436 56165 136991 5438 5439 5430 5431 5432 5440 5433 5441 54514 201164 5434 143689 5435 3320 5437 221400 122402 55124 84944 54456 11022 91646 4603 113802 8468 9271 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity 22797 1908 3094 2033 1906 7341 4157 1910 7533 27022 257 6926 4161 1615 5443 8600 4286 6663 5454 999 3397 4160 7030 1435 4159 7329 6591 7942 6195 7514 7965 7534 3376 5917 9521 3735 7529 4141 7532 7531 2058 5859 1387 23411 89780 5077 7545 6657 4140 9255 1499 3065 5594 5595 6662 10000 3815 2932 51520 51176 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin 5687 5688 5689 5700 5701 5702 991 5704 5705 9232 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 7316 27338 119504 246184 51434 51433 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) 60482 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 3060 347148 84109 8620 64106 10886 3062 3061 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins 840 6304 7431 836 5747 2339 841 5339 22985 999 5588 5580 660 6093 63967 1832 2620 8428 118 51765 28988 4137 2934 1829 1499 10134 839 1830 100506658 5317 4001 324 1828 329 7082 6709 9414 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c 29929 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 2645 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 1143 1141 1146 1145 1137 1136 1144 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 5393 7534 23016 5073 51010 167227 51013 207 118460 22894 1432 56915 11340 8570 5600 23404 54512 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 811 30849 51128 567 3134 6396 3133 9871 2923 9632 10427 3309 6890 3135 6892 6891 8678 5289 64167 51752 10802 3107 10484 3106 3105 22863 22872 821 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 7316 80196 4194 1029 1017 79109 253260 890 6446 8900 4193 208 1616 900 9099 55615 7157 5518 11200 7311 7314 64223 7874 472 207 6233 983 117584 2475 5519 10000 5515 5170 5516 5527 51230 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 6888 7086 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 10166 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer 842 84335 7249 3164 79109 253260 64223 1027 6199 4193 207 1026 4303 2931 2475 10000 208 2309 2308 5170 55615 2932 1147 572 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes 1594 1593 191 1591 1589 113612 95 1588 120227 1586 1585 1584 7172 2232 23169 2230 54658 1545 56603 26873 54657 9420 2729 112812 126410 2328 2730 2678 1583 4128 6916 2937 340665 4143 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA 35 142827 6296 3033 1892 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 8968 3013 8338 285051 255626 29128 359787 124512 7403 57379 3021 85236 8349 3018 3017 54145 3014 10765 653604 8331 8337 8334 8335 23135 200424 5927 474382 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation 192669 29126 23112 27327 26523 27161 192670 57690 4343 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 5578 1856 1175 1212 160 161 163 409 1213 1211 8322 7474 5582 5579 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia 2153 5624 5627 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 51082 5440 5441 9533 51728 27297 661 10623 171568 5434 84265 5435 55703 5437 55718 11128 10622 10621 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation 222236 MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis 7156 4683 63979 8370 55732 94239 26277 25913 65057 7013 3013 641 7329 7014 54386 255626 3021 56979 10111 4361 3018 4292 3017 54145 472 3014 545 8331 9985 8337 27127 8334 10734 672 5932 8335 11144 50511 93426 10388 23626 23345 23224 474382 6117 256126 6119 56158 6118 6847 644186 1019 23353 5889 8341 29893 8342 3306 8970 8347 27030 1017 8348 84057 128312 8345 4438 4439 8340 55766 8968 9126 8338 10735 10274 25777 8243 5885 85236 8349 653604 4001 5888 8290 8468 675 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway 5687 5688 5689 144165 1212 5700 5701 5702 409 5704 57154 5705 7855 23002 7976 8321 8322 7474 8325 8323 8324 7471 4919 6259 5582 4920 2535 81029 5216 5579 5578 1175 160 161 163 1213 1211 6233 7316 5880 5881 1855 7481 64750 5879 9861 387 5682 1857 5683 1856 5684 5685 5686 5717 5718 5719 7311 54361 7314 11047 10213 5713 23513 5714 57216 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 50855 5709 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants 2322 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 3320 4893 6654 2064 6464 3265 5782 11140 55914 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1378 1493 8784 50943 3458 861 865 3559 3558 4773 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants 598 5295 2322 5290 50507 1026 4893 9846 6654 2885 5292 3265 6777 5781 6776 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer 4088 4089 2280 7046 7040 7048 4087 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 3032 37 3030 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands 28514 1392 6750 25942 3065 627 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay 10179 51593 23144 22916 10438 1797 124245 54439 91746 84186 5394 23211 4686 8106 64848 196441 10200 64282 64062 11340 23404 64895 54512 5393 23016 51010 22803 51013 55596 118460 22894 56915 11044 23517 80335 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 79155 7316 8945 1326 6416 7311 8454 7314 6500 23291 6233 4790 3551 5604 1147 8517 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors 204851 2626 28996 8850 25937 1066 4880 4881 6910 4882 4311 4878 10699 1482 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway 111 109 112 113 114 115 2774 2771 2770 346562 196883 2773 107 108 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME 1576 5446 10599 54659 1244 28234 5243 5444 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell 7316 6457 4233 6456 8027 7311 7314 10254 6233 2060 9146 6455 30011 867 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD 26873 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle 10489 8452 9367 22836 898 10226 9146 7428 51209 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants 2263 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination 51082 10849 6908 4331 30834 84172 902 404672 2071 2068 284119 221830 7343 25885 5440 5441 2966 9533 2965 5434 5435 5437 64425 2968 2967 9014 1022 9015 7270 79101 9013 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 1544 2686 1576 91703 8574 124975 95 1553 4257 4258 4259 1800 2678 64174 22977 246181 1577 2687 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events 5724 257313 1133 5731 3708 5737 3709 5295 64407 2911 5296 387129 2358 5290 846 2915 8111 2864 8477 3710 2922 5996 5997 5998 5999 6846 2925 160851 10161 6863 185 623 624 1609 1608 747 1607 10287 1606 56923 6870 8490 2151 23566 2150 3358 3357 1956 3356 7222 6865 2829 2828 6866 6869 7225 221955 353299 885 886 887 2837 9002 5330 57121 5331 5581 8997 338557 5332 3814 10911 2840 2846 695 594857 301 57113 3269 5583 129521 128674 2867 2865 156 2863 2862 60675 4922 2869 4923 680 27334 84634 139189 4935 5367 23620 9162 10316 4828 4829 26575 5588 2520 7204 9170 10235 84539 10125 1131 5594 5595 6654 57105 10800 5580 5578 6288 183 6915 146 147 148 4314 4893 3265 351 23236 2793 2792 2791 2790 2788 2787 2847 2786 2785 2784 2783 51764 8503 9630 94235 55970 54331 2767 59345 1908 1906 1910 2769 2782 2642 2641 2776 3060 347148 84109 8620 10681 64106 10886 6197 3062 6196 3061 6195 2149 2147 11343 5598 3827 1839 5020 4295 7200 5021 115557 7201 431704 56413 8527 8525 8526 5031 5032 6003 1909 6004 94233 2798 2797 2796 1907 5028 5029 84432 1902 6375 1241 2693 26090 57406 551 10874 552 29933 553 222545 10887 1128 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 2737 2736 2735 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs 53632 808 10645 5563 5565 5571 5562 5564 51422 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS 114882 100137049 26279 255189 254531 154141 30814 8399 114884 81579 5320 5321 5322 51365 283748 22925 10162 11145 114879 5319 64600 123745 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation 5111 6119 10714 6118 5424 57804 23649 5422 5557 5558 5982 5983 84515 4172 4173 4174 4175 4176 2237 64785 8318 9837 84296 4171 51659 5981 1763 3978 5984 5985 5425 6117 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 6441 653509 6440 729238 6439 1439 1438 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation 2626 23478 3670 6934 1499 2864 5080 2922 60559 2782 28972 346562 2641 338557 2784 5122 9789 2695 51764 1045 90701 3952 139760 1803 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization 4067 2534 5295 9846 5296 6654 5170 5290 5291 7462 6850 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 5062 79658 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress 1019 1029 1021 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins 6870 6863 6865 6866 6869 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance 335 81693 8029 3069 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions 64399 91653 2619 50846 3549 5727 6469 50937 RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle 10250 6510 7919 91452 7074 55240 55004 2889 6654 10817 5825 8776 4548 8452 9462 9217 8976 11180 7126 1362 390 57584 29766 22852 6093 394 1832 57449 222584 55704 11188 3895 54514 3930 10970 8503 55789 8502 8301 91544 81839 27316 9231 9352 23513 57216 56667 10505 253980 23592 667 1828 1969 2319 8086 3954 65124 9181 55200 79658 399693 253959 5930 10652 3998 23616 124540 115703 201176 10788 57514 57636 57630 55219 64283 10424 10787 143098 55227 57522 4983 26092 22865 124997 58504 81624 1213 1124 1123 10409 55114 6811 708 4650 6709 27289 10979 114793 4646 4649 11140 55914 84904 26084 57679 6711 6714 5880 5881 114885 2010 55023 57569 79598 3336 284119 2245 27145 613 5756 26050 92799 10602 57579 10726 27035 10963 4690 115557 55843 752 54874 55968 182 10134 4688 55845 10254 4689 4580 2040 55971 51133 55852 89846 11113 10144 3688 9901 51138 85360 8936 5337 1080 5338 64333 7984 25963 147179 11329 79834 5295 537 9912 5296 5783 10818 2185 5290 23433 101059918 116984 79822 6655 9928 11214 10006 23526 6793 5585 6434 5586 10458 10451 54438 9815 10211 157285 29062 9938 23779 7410 9710 51291 54443 9826 9824 90627 9828 7409 8826 22899 3320 5361 5364 6453 8997 8874 124056 56990 3183 7535 8987 10672 3163 10435 9738 3071 4162 7431 9855 4168 80728 25813 224 79869 8773 4296 11060 7444 7204 9743 8654 94240 23048 29941 85415 83478 84681 6242 7454 11075 7456 9754 120 84317 143872 9748 27 9886 29 9644 1152 23268 64857 23380 23141 23263 221472 9639 51306 2697 9411 7112 8440 9414 5058 28964 94134 200894 388 389 9528 5063 23365 23002 391 644150 392 393 128272 23129 395 26999 396 397 398 3326 399 121512 51566 84364 10298 171177 148170 23013 23256 23370 857 25791 1829 9322 23229 8476 10152 64411 23221 23344 89839 23580 84144 70 10395 71 51347 10276 55701 9318 2802 65992 5099 7037 9459 10160 10163 9578 25894 55831 128239 1729 11135 8239 51479 54509 55717 56924 87 55160 10928 91010 9341 57580 26030 10811 10810 80243 1730 56254 22800 9235 93663 9475 8027 26049 9590 57473 7170 7171 123720 26286 80115 1627 158747 57120 8153 57480 117289 84986 50855 3932 343578 50619 50618 9497 157769 9138 221178 27237 55075 653361 57498 257106 84612 50508 6472 153478 57144 114822 57381 1536 1535 29984 1894 445582 58480 23092 3728 7415 2631 2873 144402 347902 4952 4810 50649 29843 2886 50650 152273 79180 23191 1445 23074 23075 23197 5924 85440 908 60 10376 10574 10576 80005 998 139818 55619 29127 832 1629 81704 23348 26230 1795 1794 2909 9732 57572 116985 63916 1793 5879 9146 387 7879 5062 4722 4001 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation 4803 5295 5296 5290 4914 8660 5291 3667 387 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 7841 23478 100128731 999 5589 23396 9789 9743 90701 29954 3728 10585 283106 5046 9159 5045 288 1460 6185 1499 23193 1459 6184 60559 1457 28972 3703 746 58505 1603 1650 821 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 9424 3775 10089 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 7316 5687 5688 5689 5700 5701 5702 5704 5705 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 920 5695 5706 5707 5708 5709 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 5929 2033 8370 9739 94239 4343 9070 192669 55170 23112 27327 26523 192670 2623 57690 3013 861 865 255626 23309 3021 9757 161882 3018 3017 54145 4778 3014 58508 8331 10398 8337 8334 8335 474382 8341 8342 8970 8347 8850 8348 128312 8345 25942 8340 55766 8968 5588 8338 5196 3674 2811 85236 8349 23067 8013 3065 3276 7057 653604 84661 11091 4297 8085 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 55624 1605 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism 216 229 6652 132158 26007 231 3795 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 4088 4089 4087 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression 7157 639 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation 4803 396 4804 387 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine 4968 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 26277 25913 65057 7013 3013 8338 7014 54386 255626 55247 85236 8349 4350 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 23478 6934 1499 2864 5080 2922 60559 2782 28972 346562 2641 338557 2784 5122 9789 51764 1045 90701 3952 139760 1803 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR 5295 5290 6868 10253 6456 1950 5335 1956 6233 1445 2060 8874 255324 6455 5781 7316 6457 2549 374 6714 2069 5829 685 1839 9146 222584 867 7039 8027 6464 7311 102 7314 81610 5782 58513 10252 10254 14 998 5796 8038 26018 29924 84985 55824 4893 5774 6654 3265 30011 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling 145957 3084 10718 1950 5753 2064 2069 1839 1956 685 9542 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 91433 23463 79672 79831 92715 51389 285381 120526 100137047 55239 56648 411 1725 1802 1801 23210 84864 6157 11338 347527 2155 5045 8460 2147 2107 8459 25870 285362 2159 2158 2157 8858 5624 5627 6194 2621 79642 1938 153642 2677 6228 22901 444 340075 6132 410 412 79697 414 89978 1819 415 83475 64122 416 632 1984 55854 51611 4733 65094 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes 6932 7088 7089 6934 1488 7091 1487 7090 3065 166 83439 51176 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR 4803 4804 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation 83475 56648 1984 1725 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade 1378 629 718 3080 4179 1361 1380 10877 10878 730 731 27202 732 975 733 713 735 714 81494 930 715 717 3078 3075 1370 3426 1369 712 966 716 727 2147 728 710 721 1604 722 729 725 1991 1191 7448 719 5627 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation 5436 5438 5439 22916 4686 2248 2255 2252 27006 5430 5431 2247 5432 5440 5433 5441 2263 2251 5434 5435 5437 2254 8074 2249 2963 2962 2246 8823 8817 26281 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function 5928 23478 5931 5925 4613 94239 4343 192669 5589 23112 27327 26523 27161 192670 57690 9789 3728 23193 54145 7020 6233 27085 1500 3170 79872 10399 2060 8331 117581 7750 8337 8334 8335 7316 8341 8342 6667 8347 8348 8345 4193 8340 8338 9743 9861 5682 5683 5684 5685 5686 283106 9314 5046 9159 5717 288 85236 5718 5719 8349 1499 7311 7314 11047 10213 5713 5714 60559 7979 7291 54737 5690 5594 5691 5595 5692 5693 5694 7088 5695 5706 5707 58505 54971 5708 23028 5709 821 5687 5688 5689 5700 5701 60436 8370 5702 2146 5704 5705 100128731 999 23396 3013 6591 11171 255626 1508 1495 5045 3021 1514 1460 6185 7414 116092 3018 1785 1459 94234 3017 6615 5315 6184 1457 3014 10009 6935 28972 93986 55810 687 9839 348262 746 1520 387893 8289 1603 474382 7841 6929 8970 6714 128312 1488 1487 55766 8726 8968 6938 23411 7764 90701 29954 10585 7490 3066 3065 653604 3703 6597 1650 23512 4609 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones 5928 317772 6907 57504 85235 8370 10362 5931 51317 9219 1107 9112 3013 55869 1108 8819 25855 221613 255626 92815 8969 54815 440689 3018 3017 53615 79718 8331 23186 8337 8334 8335 5926 8841 8341 8342 8970 8347 8348 128312 8345 8340 79685 8968 8338 2874 85236 8349 83933 3066 3065 653604 51742 10284 5978 64426 9612 9611 23028 57459 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling 3162 7099 6907 4862 2033 8648 338 10891 4780 6256 23643 7975 96764 5465 113235 6095 10499 3043 10498 23054 1387 8204 23411 23373 10424 406 3040 4208 7514 5469 85441 80205 6604 9575 1386 79718 9572 51266 4209 64784 200186 335 10743 9611 8841 571 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism 3707 27124 9651 253430 80271 23165 170685 9631 3613 7175 9108 3612 3631 3632 3633 9562 3635 3636 8821 51447 4952 9807 5335 64768 3628 9677 8021 55190 23007 55586 808 11163 5330 5331 348995 66036 5332 9883 5333 57122 11165 51477 55746 23236 5336 23279 5728 89869 79023 113026 10762 6396 129401 4927 8867 117283 122618 5903 9688 23225 51196 55706 23636 9972 11097 23511 8086 53371 84812 8480 79902 23262 3705 3706 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells 4072 11045 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants 5295 1950 2549 5335 2064 6464 1956 5290 3320 4893 6654 3265 11140 55914 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere 5111 10714 5424 57804 23649 5422 26277 5557 25913 5558 65057 7013 7014 54386 5982 5983 5981 5984 5985 63922 5425 79075 79991 80169 100134934 54921 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation 2247 3730 2251 10755 7049 2248 2255 27006 2254 8074 2249 2246 26281 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling 22914 9402 3937 7305 5295 3822 3824 5336 5296 54209 5290 5291 567 6850 3133 2534 5879 10451 7410 5335 4893 6654 695 3265 3932 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 4802 27113 2033 1649 10891 5443 10971 2908 208 2660 3630 901 694 7534 857 65018 6794 57060 207 4852 4287 7529 2810 10628 2309 2308 1647 5934 84676 7532 8850 23410 25942 1027 356 4087 91584 4088 4089 1387 23411 6720 10370 23460 2538 2645 9314 2290 7295 181 114907 847 5105 3066 3065 6648 1026 4303 10000 604 3484 56729 4800 4801 10018 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint 7316 5687 5688 5689 5700 5701 63943 5702 51512 5704 5705 5347 22919 3326 9861 5682 891 5683 7157 5684 5685 5686 5717 5718 5719 9133 7311 7314 11047 10213 5713 6233 5714 7979 1026 983 3320 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 30849 79643 8678 5289 51652 91782 25978 23479 81631 27243 92421 128866 7405 29082 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX 1593 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) 5111 6119 10714 6118 4913 4968 5424 57804 10038 8930 11284 23583 8505 252969 54936 5423 328 54107 142 6996 5982 5983 79661 2237 4350 5981 56655 3978 5984 5985 7515 5425 5426 5427 3980 6117 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) 6584 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation 6774 5295 5290 11160 1523 9530 613 26127 11116 399687 6777 6776 2247 6772 2260 2251 8805 9846 7750 2254 8074 2249 2246 11052 9208 26281 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 7039 1950 374 2069 1839 1956 685 255324 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins 240 239 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 283 60528 23405 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism 6844 5034 23478 1215 2864 5443 2922 1081 2782 1361 346562 2641 3972 9789 3630 3798 3799 1509 2626 3670 590 1511 5080 7252 28972 183 338557 3625 4644 3624 3623 94115 6934 23265 5873 60412 54536 2028 3479 1395 2784 64924 57393 10640 2999 5122 11336 51764 3800 2695 149371 90701 25924 6804 1045 3952 619373 4311 7941 139760 1363 1803 290 1360 83729 1359 2488 55763 9314 10159 1636 5972 3626 169026 55770 1522 1499 7349 5126 56605 43 60559 1066 59272 2688 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling 10148 6772 6774 3717 3716 9466 9244 7297 3572 821 246778 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation 51602 286053 25950 23137 11315 4152 8648 59343 10891 6294 165918 7153 7155 23314 7158 3190 5893 7150 1107 23165 7508 9631 7175 7022 4791 29843 6790 7021 3619 7428 348995 9883 57122 3183 8535 6117 5970 55746 51564 6304 1029 6045 23279 79023 648 4193 1069 6015 10762 4869 6396 1912 142 1387 1911 9656 129401 4792 80012 7486 4927 57332 84733 7518 23468 5905 9641 10155 5903 9688 23225 55706 23636 9972 83746 11097 23511 8086 53371 8480 79902 9212 2033 7341 7376 8370 7068 5241 6256 7421 5465 8554 2099 4286 7181 10499 6095 367 59348 4929 6612 2908 9112 51588 1616 9759 5468 641 7329 6613 4306 5914 10401 6996 2516 8517 7157 8021 5987 672 8924 5111 5610 10210 28996 332 25942 1487 5371 55143 9126 3622 7703 8204 10735 1789 1788 1786 10274 10055 8243 10054 5885 57591 3066 3065 9189 197370 493861 9994 3090 115426 7690 79677 56160 9612 54780 668 10521 1655 6670 6672 23512 205564 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR 1508 7184 1514 81622 1513 10695 1515 54106 7098 5641 1520 51284 51311 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis 7316 8772 7186 8795 8743 8797 355 356 83737 841 8737 8717 11035 5071 197259 10015 7332 8473 10211 10273 7311 330 7314 331 57162 6233 3320 329 2319 6386 11140 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 10454 64127 59307 11213 6279 6271 51231 1849 1848 1846 1845 4791 257397 8454 6280 7097 6233 7096 351 4790 948 10333 695 5970 7316 7099 929 7186 23643 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 2266 5602 4793 5606 28512 57161 3725 57162 2243 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 2244 6885 114609 7189 51295 8651 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e 54344 8813 8818 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling 7316 3730 10818 2248 2255 27006 10253 8569 867 2247 5518 7311 7314 2251 6233 673 5594 5595 5515 2254 8074 5516 2249 2246 5781 26281 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 7316 2549 5295 10818 5290 10253 8569 867 2247 5518 5335 7311 7314 2264 2251 6233 673 9965 5594 152831 5595 4893 6654 5515 2254 8074 5516 2249 3265 2246 10817 8823 5781 8817 26281 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle 5058 9738 28964 94134 79834 5295 6711 8239 84612 56924 79598 4296 11180 8976 57630 9815 10298 171177 4690 55789 5062 81839 57473 7170 7171 9231 1213 9352 998 8826 667 1969 8874 6709 50855 4649 8440 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle 7841 7316 811 5700 9695 6048 91445 80267 10206 56886 10956 267 84447 7844 5887 9761 10299 5589 64772 55757 55768 11236 51009 51035 2923 7415 55741 6400 79139 7311 7314 23193 6233 11253 821 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions 5058 388 389 5063 23365 23129 23396 2534 10570 10371 56896 3326 2242 57556 10507 6237 5788 80031 4628 5362 4629 5365 9723 64218 971 10154 3672 1809 8482 2064 79784 1400 4627 1808 55558 9826 3320 5361 4637 5364 10398 3984 3985 27289 103910 1020 2909 4233 7305 9855 54209 7094 91584 9037 5879 6093 8851 387 9475 5062 8829 1072 3688 2932 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 2247 5295 2549 10818 5290 2251 2248 2255 2252 27006 2254 8074 2249 2246 8823 5781 8817 26281 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME 7367 1576 54659 866 3291 1645 3290 5243 7364 213 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis 6929 4617 4618 6938 5608 25 6925 4205 4208 50937 1495 4654 1499 4656 1000 9043 1013 1496 4207 998 6300 4917 663 1002 1432 4756 4209 5600 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation 55746 5905 7341 25909 1104 5901 23279 79023 9688 3842 3837 23165 6396 55706 23636 348995 129401 9883 7329 9631 23511 57122 53371 79902 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening 10369 27092 781 782 785 9254 55799 774 783 784 773 777 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling 7316 3084 2069 685 208 10718 1839 145957 10273 1950 2064 1956 7311 7314 5782 10193 207 6233 3320 10000 8065 9101 4145 26469 9542 11140 55914 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 79944 728294 137872 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 640 5929 57678 894 896 4004 902 9739 4005 94239 4343 9070 8861 192669 55170 23112 27327 26523 27161 192670 57690 595 861 55193 865 25 5579 200845 6688 9757 54145 6233 196528 58508 8331 8337 122809 8784 8334 8335 1022 5275 8535 4773 7316 8341 8342 8347 6045 8348 8345 648 8340 6015 23466 1912 5079 1387 1911 5588 84333 8338 7122 80012 57332 84733 9861 5682 5683 5196 5684 4602 5685 5686 5717 2811 85236 5718 6601 5719 8349 6603 7311 7314 8013 11047 10213 5713 6602 5714 6605 7057 7979 6604 5690 5691 5692 5693 5694 5695 5706 5707 1998 1997 5708 5709 5687 5688 86 4331 5689 2033 5700 3958 5701 8370 5702 5704 84870 5705 2099 1437 7161 2624 2623 3977 3013 255626 23309 3021 1514 1460 1513 161882 3018 100506658 1459 3017 1457 3014 4778 8312 1515 10413 10398 8289 3562 3559 5781 474382 3558 6929 1378 9021 57492 8970 28996 8850 6714 128312 25942 26053 83737 5371 55766 1493 8968 6938 2625 1021 10138 51412 3674 23429 23067 3458 6886 3276 3065 653604 84661 11091 7082 50943 6595 4297 6597 6599 6598 8085 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 7316 7099 10454 929 353376 7311 257397 23643 7314 148022 6233 23118 6885 3656 7189 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization 7316 4734 7311 7314 5728 331 7874 5371 6233 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 50964 27121 22943 27123 4040 54361 4041 83999 7474 79412 89780 7483 6423 11197 6422 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol 113179 4234 8270 134637 79691 81605 54974 55644 55621 51002 84267 81890 2058 84520 152992 91801 57604 51605 54517 112858 93587 115708 90353 63892 221078 54482 348180 23536 1787 24140 60487 54802 54901 54888 54920 10785 83480 51504 55253 55039 57570 9836 127253 129450 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway 7316 197342 6119 6118 84464 80198 79008 2067 378708 2177 2176 199990 84126 2175 55120 64858 29089 2189 7311 57599 22909 7314 9937 91442 7398 6233 2188 353497 2187 80233 545 2072 201254 57697 2178 146956 55215 6117 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 8454 6233 7321 25906 11065 8697 7324 6502 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 1017 51433 9978 9861 5682 5683 84515 5684 4172 5685 4173 5686 4174 4175 5717 4176 5718 5719 7311 7314 4171 11047 6500 10213 5713 5714 7979 5690 5691 5692 990 51053 5693 5000 5694 5001 5695 23595 5706 23594 5707 81620 4998 5708 4999 5709 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS 1244 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines 6352 6354 6357 6356 6347 6349 10850 2826 6361 6364 9034 6363 5473 6366 6367 1230 6360 2833 1524 643 6846 2919 10663 6373 6372 6374 6376 6370 1238 2921 57007 2920 1237 3579 1236 3577 3576 1233 7852 56477 1232 729230 4283 6346 10803 51554 2829 10563 3627 1234 6348 1235 6387 5196 6375 6351 58191 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling 8772 843 355 356 841 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription 56978 26508 9839 6667 3224 6615 3609 2294 27319 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) 8671 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 4851 84441 9794 2033 3516 55534 8850 390874 22938 50674 3280 1387 2648 3175 10046 6928 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases 10250 6510 7919 6279 91452 4627 6280 7074 55240 55004 1499 2889 5594 5595 6654 10817 9212 9184 991 5300 4085 701 995 5580 7514 5578 7534 5825 7529 1432 5600 332 8776 4548 8452 9462 23081 348995 57122 55746 9217 23279 79023 6396 8976 11180 7126 1362 390 57584 29766 22852 6093 394 1832 57449 222584 55704 11188 3895 54514 3930 10970 8503 5905 55789 8502 8301 91544 81839 27316 9231 5903 9352 23513 57216 56667 10505 253980 23592 667 1828 1969 2319 8086 79902 3954 65124 25909 9183 9181 55200 79658 399693 253959 5930 10652 3998 23616 124540 367 115703 201176 2316 10788 57514 57636 57630 55219 64283 10424 10787 143098 4628 4629 57405 55227 57522 4983 26092 1495 22865 79784 10403 124997 58504 81624 1213 1124 80776 1123 10409 55114 6811 4637 708 5519 4638 4650 5525 4771 5515 6709 5526 27289 5516 10979 5527 114793 5528 4646 4649 5529 4660 11140 91687 55914 57551 84904 79682 26084 57679 6711 5747 6714 5880 5881 114885 2010 2491 55023 57569 79598 55143 3336 284119 2245 27145 613 6722 5756 26050 92799 10602 57579 2017 10726 27035 10963 4690 115557 1063 1060 151648 55843 752 54874 1058 55968 182 10134 4688 55845 10254 4689 4580 2040 55971 51133 54763 55852 89846 11113 10144 3688 9901 51138 85360 8936 5337 1080 348235 5338 64333 7984 25963 23421 147179 11329 51143 79834 5295 537 9912 5296 5783 64105 10818 2185 5290 23433 101059918 116984 79822 6655 9928 11214 10006 23526 6793 5585 6434 5586 286205 10458 10451 54438 9815 10211 5216 5579 5217 157285 29062 9938 23779 7410 9710 51291 5590 10109 54443 9826 9824 8655 90627 9828 7409 8826 22899 1781 3320 5361 64130 5364 6453 8997 1778 8874 124056 56990 3183 695 699 7535 10552 8987 10672 3163 140735 10435 9738 3071 25936 4162 9793 7532 7431 7531 9855 4168 80728 23332 25813 79980 6232 224 79869 8773 54908 5500 10093 5347 4296 11060 22919 10092 7444 10095 10094 7204 10097 9743 4659 8654 10096 94240 23048 5048 354 29941 85415 83478 151246 9735 84681 6242 5518 7454 11075 7456 9754 5289 120 84317 143872 9748 27 9886 29 9644 1152 23268 220134 57082 54820 64857 5501 23380 23141 23263 221472 5170 6249 9639 51306 2697 9411 7112 8440 9414 5058 28964 94134 200894 388 389 9528 54821 5063 23122 23365 23002 391 10971 644150 392 393 999 128272 23129 395 26999 396 397 398 3326 399 121512 55920 51566 84364 10298 171177 148170 23013 23256 94274 23370 857 25791 1829 9322 23229 8476 10152 64411 23221 23344 3817 89839 23580 84144 11243 70 2810 10395 51466 71 10398 51347 10276 55701 9318 2802 65992 5099 7037 9459 10160 10163 9578 11130 25894 55831 128239 1729 11135 8239 51479 54509 55839 55717 56924 87 8379 55160 10928 91010 9341 57580 1855 26030 10811 10810 80243 55166 1730 56254 79019 1857 1856 22800 9235 93663 9475 8027 26049 9590 57473 7170 7171 57591 79003 1742 55055 123720 26286 80115 81565 1627 158747 57120 8153 57480 117289 147841 84986 50855 3932 343578 50619 50618 9497 157769 9138 30849 221178 401541 7533 27237 55075 653361 57498 257106 94239 84612 50508 378708 6472 153478 1780 79172 57144 114822 57381 1536 1535 29984 1894 445582 58480 23092 25 3728 7415 30851 2631 2873 1783 144402 347902 4952 4810 83540 80152 50649 29843 2886 50650 54145 3619 152273 79180 64946 9055 808 23191 1445 23074 8331 23075 8337 23197 8334 3984 8335 3985 103910 51517 5924 8341 85440 8342 908 8347 8348 8345 8340 60 8338 10376 10574 10576 85236 1062 8349 64837 80005 147700 998 139818 55619 23028 29127 8370 10499 81930 4221 3013 84643 832 3796 1629 3831 3798 255626 3799 3021 3018 3017 3014 81704 23348 26230 1795 1794 89953 11004 474382 2909 9732 57572 8970 128312 1027 55766 116985 63916 8968 1793 5879 9146 387 7879 5062 4722 653604 4001 1072 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine 1312 220074 6531 4128 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors 2796 7253 2488 122876 170589 3973 3972 2492 2798 7252 2797 1081 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 1174 940 1175 160 161 163 162 164 567 926 375 3105 920 8907 8905 51606 55690 3932 130340 10053 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD 191 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux 9682 6907 341 2033 346 6257 8648 7376 344 6256 348 4343 192669 23112 27327 26523 347 27161 192670 57690 2874 64241 19 64240 10062 79718 80820 9619 221656 9612 1071 10123 9611 23028 8841 55818 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown 55746 23175 23279 2010 79023 5347 10762 23165 6396 129401 9631 7175 4927 891 5579 64900 5578 8021 9133 5903 9663 9688 23225 983 4001 23592 55706 8815 23636 348995 9972 9883 11097 91754 23511 57122 140609 8086 53371 10783 7443 8480 255919 79902 221496 23399 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling 7316 5518 7311 7314 6233 673 5594 5595 5515 10253 5516 8569 5781 867 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance 506 509 3418 4343 192669 513 23112 514 27327 26523 27161 192670 515 57690 516 517 518 521 522 2101 9662 8655 7840 11064 539 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 23408 5577 23409 9814 140735 9738 11190 9793 7532 7531 10383 10382 23332 25813 115106 23410 79441 95681 1069 5347 22919 54801 10498 10142 7846 9702 10540 5108 4218 11116 4751 5048 55142 22897 54930 5116 79959 28514 80184 5518 93323 7277 80205 3313 23354 22981 8481 80254 53632 983 121441 1386 55755 54820 10806 10121 5566 55835 55559 8636 11258 84131 4957 4851 10476 200894 51422 7161 5564 1874 5571 3842 4508 1432 4509 5563 5565 56623 4209 64784 200186 5600 9742 10632 23322 55081 55764 79659 8100 51098 79809 26160 6608 11127 57728 57539 54903 2746 498 2747 6907 8648 10891 96764 23054 89891 6991 64792 9321 92104 11020 57560 83657 150737 83658 200132 56912 51668 6300 255758 51626 808 112752 90410 23059 55112 26146 28981 57576 79989 80173 6753 5147 27241 5310 5311 261734 55212 117177 51134 403 10013 51259 54806 4735 6010 6950 7203 23265 92482 84902 84747 378 60412 84100 54536 4867 2847 9657 1387 91147 27077 54205 85302 10640 11336 129880 149371 347240 1262 1260 9551 211 22832 10694 57787 57545 10576 1258 9556 4602 123016 10575 55763 79738 85441 8729 26005 166379 55770 79600 26123 79969 50807 8195 132320 6604 6102 8766 146057 582 9572 583 54585 22920 585 27031 51053 79867 192668 9727 1875 9371 6256 5465 22948 10499 55902 29841 23373 3797 27109 4208 80776 7027 79718 8841 2551 2302 56652 10651 125988 10309 814 54927 124093 5990 5991 10989 647309 7019 51106 159989 6742 79598 84808 79135 11232 55735 345643 5442 64216 7978 3054 139322 8834 440574 23082 57822 79977 84303 5469 133522 4899 84833 6648 4580 9611 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily 8313 8341 2033 8342 8970 8347 8370 8348 1728 128312 4780 8345 7975 94239 8340 55766 8968 1387 3013 8338 84181 57680 255626 3481 85409 79843 55636 10664 3021 85236 27123 8349 1499 80205 3018 3017 54145 3014 653604 8331 8337 11091 8334 8335 474382 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis 159 7372 1723 10606 3615 2618 3614 790 5471 471 8833 5198 122622 158 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation 2767 59345 5173 9630 4988 94235 2769 2793 2792 5443 2791 2790 2782 2788 2787 2786 55970 2776 2785 2784 2783 10681 51764 54331 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway 5058 2534 940 941 942 5062 5063 5879 3932 998 7409 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release 811 821 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation 2990 3161 23553 3373 8372 3074 55576 3073 6677 6548 960 10894 26503 8692 11261 57214 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage 836 837 3553 3606 79792 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 10585 1605 29954 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules 5058 9402 3937 5336 5063 917 4690 7454 3123 5062 5335 3122 3120 55740 3119 3118 3117 3115 3113 915 27040 916 9398 51466 2533 3127 3126 3125 920 7408 3702 7535 3932 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation 5699 9554 50489 10952 653361 567 6279 1536 1535 6271 6280 7097 6233 7096 948 6810 10333 695 7316 7099 929 23643 8773 2923 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 811 5689 5700 5701 5702 5704 5705 2209 3551 4360 1147 8517 4615 3146 6890 3693 6892 1514 6891 3685 2266 2243 1515 3107 3106 3105 1520 2244 3134 3133 8673 9341 114609 3135 4012 4688 4689 55176 9902 29927 5721 5696 5720 23480 5698 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 55584 6844 6853 6616 129446 5864 440699 25861 9381 27445 161497 124590 246213 829 51168 11344 8573 64072 8927 4647 53904 494513 3778 9750 3779 9478 259236 65217 23136 339768 830 117532 832 117531 25794 283310 643226 340990 286262 375611 2036 3781 4354 10518 5357 53405 2934 7430 10083 57053 4627 64787 222662 83715 9132 80331 389207 2059 51475 5962 140469 6855 6709 490 4641 776 6711 783 5756 6804 9254 4478 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 6929 2033 5664 6667 5663 7042 6256 409 92 4613 4323 4343 4088 192669 4089 23112 4617 408 27327 4325 26523 4618 27161 6938 192670 55851 57690 83464 5914 7040 6925 2247 4654 4656 7046 7048 83855 23385 51107 10755 3070 7049 7077 7076 3624 3623 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade 2812 7450 2815 2814 2153 2811 2147 196527 3053 2160 5270 2159 2158 2157 5104 5624 5627 462 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) 2033 3726 3397 1108 9261 6197 6196 6195 4205 4208 51231 2002 1849 1848 9252 1846 1845 2152 466 1958 1785 6236 5519 1432 3399 4066 4209 8941 8061 5515 10221 4664 5516 4665 5600 1020 1959 5528 5598 3398 23237 1961 7166 1960 7425 429 6457 6446 6938 6722 3727 2354 8851 2353 5518 5594 1386 5595 5978 3400 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 7316 4052 7043 4053 4054 2280 7042 56937 57154 23327 4087 8425 9110 5500 4088 4089 4738 51377 64750 4092 7040 11171 867 7514 23645 5045 10273 3693 3694 3685 7311 7314 3690 5499 25805 7046 7048 6233 3696 9958 7049 5501 8516 3688 9040 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 7316 3084 10000 208 2064 9101 7311 7314 10193 207 9542 6233 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 130589 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids 5740 11283 8529 126410 1582 6916 57834 1580 4051 66002 1579 284541 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 3665 54106 7334 51284 51135 7335 7189 3654 4615 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters 51296 6564 121260 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation 8660 3630 2887 3643 3667 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption 6514 6248 6518 6523 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism 7316 378884 83592 5236 2632 5255 5256 5257 5261 7360 5260 7957 2548 8908 7311 7314 6233 178 808 2998 2997 2992 5507 5834 5836 5837 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 6480 256435 27090 6483 6482 2589 6484 6487 10610 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins 10714 5929 51143 56259 80349 4627 8655 4292 6233 1870 4790 1781 1778 920 5395 5970 7316 140735 4298 8888 4068 85403 5971 114836 2213 6830 959 4300 6712 3689 59067 5079 3221 3112 10540 3111 7709 3109 3108 27125 55840 1075 93661 5982 5429 5983 23308 8832 3384 3383 55860 1512 1510 11201 1519 8722 3394 7311 115650 7314 10120 51164 7412 83547 84516 10437 27301 10671 10673 5984 60468 5985 55677 604 10121 11258 6774 4436 114876 1380 11340 23404 5980 54512 10459 51455 1509 144455 1508 5393 23016 1514 1513 51010 51013 118460 1515 22894 56915 79733 1520 9156 1378 5111 11127 57379 6595 6597 6599 6598 6908 718 129685 54623 6872 6874 6873 9070 1780 23054 6749 22976 6881 6880 5430 6883 5431 6882 5432 8148 1783 5433 6884 6917 4791 51497 11198 6875 6878 83860 4207 8812 6877 58508 6879 2963 2962 4094 5436 5476 10538 5977 6921 5438 23168 6924 5439 6923 7975 3565 7469 138474 3662 79447 8178 1387 60 605 6829 8110 6827 6778 4602 9150 24137 1025 6601 1062 2956 64837 6603 1639 51616 26153 6602 6605 147700 6604 25920 54457 51224 7936 22920 1050 79577 29127 123169 904 1875 10112 905 86 9371 9493 26039 829 6760 81930 84643 830 832 3796 3797 3831 3798 3832 3799 5440 5441 3835 285643 5434 5435 5437 56992 9646 89953 8289 11004 6929 57492 10438 29851 5394 10200 9274 3683 9275 3727 2354 7879 973 7403 974 3676 3123 3122 3120 3119 3118 8193 3117 3115 5981 3113 84661 3127 3126 3125 11091 3688 5425 8085 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 8647 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 1798 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) 6616 9900 22987 9899 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy 7417 7419 79065 200894 54543 11315 51143 9804 9927 51422 1780 123 5071 29110 5564 3312 7415 1783 4077 5830 8408 8878 84749 65018 1460 5571 8655 1459 472 6233 1457 1781 3320 5563 1778 5565 7323 55669 2034 7316 140735 10133 10013 7416 8100 7322 10226 7332 7334 7335 5116 9868 7311 7314 81631 53632 3297 9140 51001 10452 9474 1068 84557 100188893 1080 139341 401505 56993 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress 10808 2033 27000 26353 259217 1410 116835 7266 51182 573 3337 6767 51501 57805 23165 9531 22824 6782 3310 10728 91582 3326 3305 9631 9529 7175 10049 9261 3308 3312 7415 3309 84335 8021 64223 472 3320 545 348995 9883 57122 3304 6117 6119 6118 55746 10013 3306 7531 815 816 817 818 23279 79023 57521 10762 1915 9532 6396 9530 1387 2288 23411 129401 4927 3313 5903 9688 23225 2475 5594 5595 3297 55706 3281 23636 9972 11097 23511 8086 53371 8480 2932 79902 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 7099 929 11035 8772 353376 23643 148022 841 8737 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle 10576 10250 11329 908 7919 27316 23221 9352 55023 87 124540 3320 8452 71 1627 6434 3326 5756 29766 3183 4646 10574 11140 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer 4088 2280 7046 7040 7048 4087 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP 8772 7186 8795 8743 8797 355 356 841 8737 8717 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling 4023 338 344 116519 345 335 336 348 337 338328 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6531 NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein 55746 23279 79023 10762 23165 4869 6396 129401 9631 7175 4927 8021 1104 5901 5903 9688 23225 3837 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing 6431 5356 10250 22794 3188 3184 51362 199746 9716 7919 3192 3191 6427 3190 6426 9939 8896 6429 6428 10189 6434 10084 65109 8683 8449 9775 23350 9295 9343 10569 10921 56259 11338 55110 4116 7307 10946 3178 4670 3187 10907 9360 5725 27339 83443 3183 3312 6632 10772 11193 24144 8899 55100 143884 51428 23398 3550 9092 6628 22985 55234 8559 57794 58509 6936 59286 79576 6634 6633 58517 51690 6636 51691 10262 6635 11157 6637 151903 10713 10236 5511 55702 5411 23524 153527 60625 57703 84811 11017 9584 6631 10929 6625 6626 135295 27258 84950 9128 9129 26017 23020 10915 85313 7737 63932 9130 9879 4236 9410 79706 57819 84081 1655 25949 9416 10181 79171 4809 91603 1659 23658 55094 27336 5093 79165 5094 26121 51593 163859 25804 22916 84844 79753 55660 7536 51747 23759 51634 51759 4686 8175 51503 5430 5431 55696 5432 5433 56949 5546 2963 2962 5436 51639 10179 5438 5439 51645 10291 10283 8241 10286 10285 27316 1660 1665 10284 84991 2521 4904 22826 22827 54883 11325 55749 23451 10450 5440 5441 10465 53938 22938 5434 5435 5437 24148 51340 57461 27238 51729 10992 10523 3181 3185 988 6627 6629 220988 23450 6638 10594 23517 9785 6430 6432 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation 7316 6457 374 2069 685 1839 10253 9146 867 7039 6456 1950 8027 1956 7311 7314 5782 58513 10252 10254 6233 998 5796 29924 2060 5774 8874 255324 6455 30011 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) 6844 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion 1729 2766 634 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system 2161 2147 710 3818 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling 10454 64127 11035 51231 1849 1848 1846 1845 4791 257397 8454 6233 7321 351 4790 7323 5970 7316 7099 10133 929 8772 7186 353376 23643 148022 23291 841 8737 7322 8767 4792 5608 7334 7335 2353 8945 9641 5518 3661 7311 330 7314 6500 3654 3656 5594 1386 5595 5604 329 3665 10010 3551 29110 9261 6197 84166 6196 92610 1147 6195 4205 8517 4208 10392 79155 79671 7157 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 3725 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 5781 6885 7187 7189 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis 27248 7316 5687 5688 5689 5700 5701 6048 5702 91445 5704 5705 10956 11160 10613 51009 9861 7415 5682 5683 5684 5685 5686 6400 5717 79139 5718 5719 7311 7314 11047 91319 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 1080 5708 5709 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly 9391 83990 22 64210 5424 4682 57019 10101 2068 64428 27158 51647 51750 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism 2023 5230 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia 445 57407 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere 5928 23421 8370 401541 5931 64105 94239 378708 79172 3013 55320 51773 55355 255626 11339 387103 54069 80152 8607 3018 3017 54145 3014 64946 8331 8337 8334 8335 474382 91687 79682 8341 8342 8970 8347 8348 128312 8345 8467 2491 55839 8340 55766 4869 8338 55166 79019 1060 85236 1058 8349 201254 57082 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation 2247 2261 2254 8074 2249 2246 8823 8817 26281 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis 111 112 113 3708 114 3709 115 5336 5613 2268 3710 917 3055 6850 2209 4067 196883 2534 2214 2212 5573 5575 5576 7525 107 108 5567 10768 109 5568 5335 808 5566 3586 5577 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA 9060 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases 29844 317772 5687 54891 5688 86 79913 5689 5700 5701 85235 54617 5702 10445 5704 5705 283899 83444 4798 4738 51377 3013 7040 221613 114785 55252 55777 92815 3607 8969 8314 7345 8607 7347 221937 123228 171023 6233 9958 8331 8337 8334 8335 221656 7316 7528 580 3054 60 8338 4092 8473 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 7046 5713 7048 5714 7979 5690 5691 5692 5693 5694 125476 5695 5706 5707 5708 5709 93973 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 145957 3084 5295 1950 2549 5335 2064 6464 2069 1956 5290 685 3320 10718 4893 6654 1839 3265 9542 11140 55914 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling 6773 9021 3456 3442 3454 3441 5777 3440 11274 3439 7297 3452 3451 3449 3448 3446 8651 3716 3445 5770 3444 3443 5781 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO 6091 9353 6092 6714 6586 4753 6585 1630 9423 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors 2893 5578 160 2891 5582 9463 7102 2892 2890 23426 4905 80852 5579 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 6790 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 9738 3161 11190 9793 7532 7531 10383 10382 23332 115106 79441 22974 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 22897 54930 5116 79959 80184 5518 93323 7277 23354 22981 8481 80254 983 121441 55755 54820 10806 10121 5566 55835 55559 8636 11258 84131 4957 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) 6844 127833 6857 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding 4074 6844 1212 27243 3312 4952 2799 6456 1785 1213 1211 1777 11154 351 8906 9179 134829 157807 375 6810 7164 7037 9026 10053 8775 388552 3482 7163 6272 10618 286451 8546 6643 162 164 27131 81567 8773 55330 2512 54885 152503 408 9829 8673 9685 26258 1362 2495 2647 8907 10717 8905 5878 84062 9146 2804 51429 130340 9698 1176 23431 64746 1174 8729 2580 23557 8301 25977 1522 6845 5286 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i 85365 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 9152 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis 10062 8204 6257 6256 5105 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters 153201 206358 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels 30818 80333 30819 3750 3751 3752 30820 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors 23421 147179 51143 64105 23433 9928 10006 6279 5585 5586 286205 10458 5216 5579 5217 4627 5590 10109 6280 8655 8826 1781 64130 1778 124056 695 699 10552 140735 3071 25936 9793 7532 7531 23332 6232 79980 54908 10093 5500 5347 22919 10092 10095 10094 10097 4659 10096 5048 354 29941 85415 151246 9735 6242 7454 5518 7456 5289 1499 220134 5594 57082 54820 5595 23380 5501 5170 6249 5058 9212 388 389 54821 9184 5063 23122 991 23002 5300 391 4085 644150 10971 701 999 995 26999 5580 55920 7514 5578 94274 7534 10152 3817 7529 11243 2810 51466 1432 71 10398 5600 10163 11130 128239 1729 332 55839 8379 91010 1855 10811 10810 55166 79019 1857 1856 9475 57591 79003 1742 55055 81565 57120 147841 30849 401541 7533 653361 94239 50508 378708 1780 79172 114822 1536 1535 29984 25 30851 1783 23081 83540 80152 54145 3619 64946 9055 808 23191 8331 348995 8337 8334 3984 8335 3985 57122 103910 51517 55746 8341 8342 8347 8348 8345 23279 79023 8340 6396 8976 60 8338 6093 3895 5905 85236 8349 1062 64837 5903 147700 998 79902 23028 25909 9183 8370 10499 367 2316 81930 10788 4221 3013 84643 3796 10787 4628 3831 4629 3798 57405 255626 3799 1495 3021 79784 10403 81624 3018 3017 80776 3014 4637 5519 4638 5525 4771 5515 5526 89953 5516 5527 114793 11004 5528 5529 4660 474382 91687 57551 79682 5747 8970 5880 128312 1027 2491 55766 55143 8968 6722 5879 2017 10726 387 27035 4690 1063 1060 151648 5062 752 1058 4688 55845 4689 653604 54763 1072 11113 3688 8936 1080 348235 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family 5928 29126 5929 5777 5295 3091 5296 5290 5291 4613 4343 192669 23112 27327 26523 27161 192670 57690 595 8454 25937 6233 7409 4790 920 8405 5970 7316 7532 6934 253260 7004 7003 7005 4067 4751 9861 23308 5682 2353 5683 5684 8945 5685 5686 5717 5518 5718 5719 1499 7311 7314 11047 6500 10213 5713 5714 7979 53632 2475 5690 5691 5692 5693 5694 5170 5695 5706 5707 58505 5708 5709 51176 5058 5687 5688 5689 6774 5700 5701 5702 5063 6048 79109 5704 91445 5705 100128731 917 10956 51422 51009 2534 55615 5562 5564 940 941 942 6185 5571 64223 6184 207 5563 5565 57761 746 80380 9020 467 1603 5781 9402 9978 10613 10331 84061 6772 7991 201595 10000 8452 3703 3716 4297 3932 1650 23476 5294 5931 94239 9070 5293 208 7525 7415 4791 91319 54145 58508 1445 8331 8337 8334 8335 5133 8341 8342 23533 8347 8348 4780 8345 151888 8764 8340 11160 1387 8338 83439 8463 8503 79139 85236 8349 142678 998 2932 3659 146850 6932 2033 8370 2146 3013 255626 6400 1326 3021 1460 3018 1459 117145 3017 3725 1457 3014 5519 10413 5525 5515 5526 5516 5527 5528 5529 474382 2034 27248 1019 8970 128312 55766 1493 8726 8968 5879 3727 2354 5062 3123 3122 3120 3119 3118 3117 3115 3113 915 653604 916 84661 3127 3126 3125 11091 10987 23512 4609 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 2626 23478 3670 2864 5080 60559 28972 5122 9789 2695 90701 139760 1803 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway 5687 5688 5689 5700 5701 5702 5704 5705 8600 1147 8741 4791 8454 6233 8784 9020 7124 8771 4055 4050 1896 7316 4049 8740 7133 8744 7186 4982 8742 7293 7292 3604 60401 51330 5971 8764 356 23495 23291 608 8792 959 128178 8995 970 10913 939 943 944 9966 8718 7187 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 330 7314 115650 11047 6500 10213 5713 5714 7132 7979 5690 10673 5691 9039 5692 329 5693 5694 5695 5706 5707 9040 5708 5709 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation 7316 5687 5688 5689 5700 5701 5702 5704 5705 9861 5682 5683 5684 5685 5686 5717 5062 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand 7099 3929 929 3146 338 23643 2266 6280 7097 2243 7096 948 6279 1687 6271 10333 51284 2244 79792 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins 503614 245911 117285 1235 1673 245936 140850 245937 1672 245938 245939 245927 245928 245929 81623 613210 613211 245930 245932 245934 644414 503841 641517 504180 613209 400830 729230 245940 7097 7096 55894 100133267 140881 245913 503618 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions 3672 8829 286 3688 27255 3673 8515 10752 3312 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF 4803 4914 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes 64764 148327 84699 10488 8720 51360 81501 153222 90993 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders 10568 285195 6569 142680 340024 246213 6505 54716 6507 6521 9056 23165 6531 153201 6530 60482 6524 6523 9631 7175 1811 11254 11136 30061 6519 6566 6557 6559 8021 6575 6578 1836 10599 348995 9883 55630 57122 283652 23443 55746 116085 55343 10999 6005 6584 9990 7355 23279 682 79023 9197 8671 10762 56606 55315 6396 26503 5172 6520 129401 1356 4927 6513 4891 123041 2646 6514 2645 9843 3098 5002 10559 5903 9688 23225 9152 55706 28234 23636 9972 11097 81031 23511 8086 551 53371 9187 552 8480 553 79902 554 6528 10479 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling 4233 388 9475 389 2064 79784 4627 23365 9826 4637 5364 10398 3984 3985 27289 5879 103910 10507 6093 6237 4628 4629 387 2909 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) 7355 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 64900 57678 23175 150763 9663 8694 80168 2713 2712 2710 84649 392636 346606 116255 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose 54344 8813 8818 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin 217 4128 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 113457 347733 10383 27183 10382 91782 7278 25978 7280 27243 79861 92421 81027 128866 7846 10376 80086 260334 6683 9798 79643 7277 200014 51652 347688 51807 10381 112714 84790 84617 221496 29082 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 3073 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex 2874 6907 79718 9612 9611 8841 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 57134 4121 10905 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 4851 54492 54567 6907 26508 2033 57534 5664 3091 5663 409 3280 3714 55851 9759 6868 83464 55869 84441 9794 55534 388585 892 8454 6233 22938 23385 51107 79718 10046 8650 8841 7316 51564 113878 23220 92737 10013 8788 10014 1272 8850 1840 79885 9978 83737 408 1024 1387 23493 9734 23462 28514 3516 83933 7311 182 102 7314 9148 6500 3066 3065 142678 2648 7088 7089 9612 26960 7091 9611 4609 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C 5687 5688 5689 5700 5701 5702 5704 5705 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 51433 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer 2305 1051 5777 6774 6194 3726 5925 9978 4343 29851 3662 597 192669 4869 26523 27161 192670 57690 3002 6776 891 1786 3587 8454 6500 3065 7291 5594 5551 51530 5595 7535 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 7378 84618 4907 30833 1807 1806 151531 1890 64902 56953 51733 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle 57128 38 6391 6390 23410 644096 6392 3418 122961 81689 2395 54949 50 1431 6389 135154 751071 57001 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects 3251 100 353 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation 5436 6921 5438 6924 5439 6923 7469 8178 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 51497 11198 8812 25920 5434 5435 51224 5437 7936 2963 2962 904 905 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway 5959 126 216 127 8644 1592 51109 112724 10170 9249 8854 64577 157506 1381 220 10901 195814 57665 8608 56603 124 340665 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching 6091 6092 8440 6585 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling 145957 3084 10718 4893 6654 6464 2069 1839 3265 685 9542 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 7157 144455 898 1017 9134 57060 890 1027 8900 1869 1820 1026 25946 79733 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 6119 7516 7156 6118 5892 5889 4683 79728 3364 83695 580 641 10524 7486 5982 5983 83990 84126 10111 4361 472 7979 1763 545 144715 80010 5984 5810 5985 5888 672 5932 5883 5884 116028 11073 10635 5890 9156 675 6117 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription 7425 429 6457 2033 3726 6446 3397 6938 6722 3727 1108 2354 8851 2353 2002 2152 466 1958 1785 1386 6236 3399 5978 4066 3400 4209 8941 8061 10221 4664 4665 1020 1959 3398 23237 1961 7166 1960 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 5921 5829 9564 9844 63916 1398 4893 1793 5753 5879 3265 387 2909 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) 675 7979 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 5111 6119 10714 6118 5424 57804 2956 4436 4292 3978 5395 5425 9156 6117 RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle 65124 9138 388 5295 9181 5296 23365 23002 392 11214 6793 5585 398 5586 1894 64283 23092 10211 3728 4983 857 7410 54443 50650 9826 81624 90627 9828 70 10395 4650 10276 5099 4649 7037 2909 55914 4162 128239 1729 4168 80728 8773 55160 284119 9341 57580 613 9743 57584 6093 394 29941 85415 115557 6242 9475 55789 9754 81839 9748 29 2040 11113 2319 23263 9639 29127 7984 9414 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL 8503 5295 5296 5290 29760 5291 3055 6850 2889 7409 5293 4067 1398 2534 1399 7525 867 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions 30835 79908 7498 5493 11119 11118 696 56244 11120 10385 153579 10384 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation 54107 56655 5557 5558 5426 5427 23649 5422 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID 4790 3551 4792 4791 1147 8517 5970 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death 7316 8772 7186 8795 8743 8797 355 356 83737 841 8737 8717 11035 5071 197259 10015 7332 8473 10211 10273 7311 330 7314 331 57162 6233 3320 329 2319 6386 11140 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling 51561 149233 5034 6774 829 3717 5478 759 9049 6175 4507 375 9446 5908 6888 6950 7297 6772 3181 9987 6775 3185 5062 3936 654483 3458 5898 3313 6845 9466 6647 6627 9244 3572 6648 998 4282 246778 10148 5055 4001 3595 3594 3593 3592 1072 27250 2939 302 3716 3586 1265 5721 4478 5306 821 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway 673 5594 5595 5604 5605 5894 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade 2549 5295 30849 5296 10818 5290 5291 3667 208 2248 2255 2252 27006 3630 2887 3643 2323 2247 2322 5289 6464 2264 2251 117145 9965 5594 54106 152831 5595 5140 4893 9846 6654 57761 2254 5170 8074 2249 8660 3265 2246 8823 5781 8817 26281 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 9738 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 22897 54930 5116 79959 80184 5518 93323 7277 23354 22981 8481 80254 983 121441 55755 54820 10806 10121 5566 55835 55559 8636 11258 84131 4957 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism 9962 9963 1528 1727 9446 6513 119391 6515 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 5335 4915 627 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) 1811 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 2247 5295 2549 10818 5290 2254 8074 2249 2246 8823 5781 8817 26281 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 3320 8578 811 10808 338 10525 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 6480 256435 27090 6483 6482 2589 6484 6487 10610 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism 55312 55065 5167 113278 54 80308 79581 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 7157 23368 7159 332 1121 8626 79370 7161 64065 604 9540 5875 5876 10397 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism 161823 22978 5105 124 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) 3098 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) 123041 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling 10148 6772 3595 6775 6774 3717 3592 3716 9466 7297 3572 821 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells 7316 999 1500 79872 6714 1499 7311 7314 6233 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 1019 894 898 896 1017 5925 9134 1027 1869 1870 1026 7027 1028 1871 595 7029 1021 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis 4969 11046 6483 79369 6482 6484 176 9469 10678 6487 10331 4958 11081 2683 4166 11041 2331 9334 9435 5549 9331 8534 23563 8703 10402 8704 4060 8702 93010 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 10605 1977 8106 129563 26986 1981 79670 9775 23318 1975 1974 1973 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 11001 10478 26061 5264 55825 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle 23013 2873 10576 10250 11329 7431 9475 27316 9352 79869 5930 9886 8452 1627 6434 8654 3183 9318 51138 6093 4646 10574 56254 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin 5687 5688 5689 5700 5701 5702 5704 5705 890 8900 8454 6233 6502 7316 1017 9978 9861 5682 5683 84515 5684 4172 5685 4173 5686 4174 4175 5717 4176 5718 5719 7311 7314 4171 11047 6500 10213 5713 5714 7979 5690 5691 5692 990 5693 5000 5694 5001 5695 23595 5706 23594 5707 81620 4998 5708 4999 5709 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 4809 51602 10171 6201 79050 84916 6203 10813 23160 27042 55127 54555 54433 84128 51202 8602 92856 65083 11103 1736 9277 25879 10528 9790 51096 55651 55813 5822 27292 4839 56902 2091 115939 25926 114049 27340 27341 10436 57647 6208 55623 55226 88745 55505 10199 6187 9136 57050 51504 22984 55272 51077 10607 11056 9724 84135 134430 51118 10885 6194 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB 5567 111 109 112 5568 113 114 115 5613 808 196883 5573 5566 5575 5576 26960 5577 107 108 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity 7316 5687 5688 5689 1029 2033 5700 5701 6714 5702 5704 57154 5705 4193 64750 864 865 7040 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli 5928 3417 5925 7422 475 1670 1870 50507 84701 2137 2135 51360 538 10498 25994 405 406 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 11047 10213 5713 5714 7979 5690 5691 5692 2168 5693 5694 5695 5706 5707 5708 5709 4851 5687 5688 5689 5700 4363 5701 5702 8720 5704 5705 341947 8714 5580 11340 8570 9261 23404 54512 3312 7514 7184 5393 23016 8021 5073 51010 167227 51013 207 118460 22894 440 1432 56915 5226 3304 5600 1465 6620 111 112 113 114 115 3329 9978 196883 10370 5573 5575 5576 2778 107 108 5567 109 5568 6122 6124 6123 6125 6130 6133 6132 6135 8452 6134 6137 6136 6128 6129 6142 6141 6144 6143 6146 6147 5293 6139 23165 6138 6152 6155 9631 6154 7175 6157 6156 6159 6158 6164 6166 6165 6168 6167 6169 6160 6161 6175 6176 6171 6170 6173 7323 348995 9883 57122 55746 6921 6181 6923 1728 23279 79023 10762 6396 129401 4927 3159 5903 9688 23225 3297 55706 3281 23636 9972 11097 23511 7086 8086 53371 8480 79902 4800 4801 4802 1649 3397 22926 3551 1327 9451 23373 1147 2289 8517 118 3309 1329 1340 1337 4846 1339 3690 1351 1350 1349 5519 1347 1346 1345 5515 5526 139285 4862 3306 11331 30968 10730 116832 4899 5029 3688 613227 5611 4609 3091 5296 79728 5290 5291 4343 192669 23112 27327 26523 192670 57690 200916 155066 9114 7321 4790 25906 11065 8697 7324 10393 29945 29882 523 996 27287 525 51343 526 51529 527 528 8881 64682 529 5970 3163 27338 119504 3162 1051 246184 1029 127124 3569 6667 51434 51382 51433 6230 23410 6232 533 6231 534 6234 6235 6227 6229 6228 245972 245973 9641 9550 81631 8992 90423 10312 5170 9296 2697 114548 2534 3326 3456 6188 6187 6189 2931 51266 4209 64784 200186 10743 9349 6191 6193 6192 6194 3921 6772 2729 9377 2730 10000 2197 140032 6201 6203 6202 96764 208 6210 51065 7415 6205 6204 6207 6206 6209 6208 6223 6222 6224 24145 7428 6218 6217 808 10628 5027 781 6502 782 374 5154 4780 7975 2793 2792 2791 2790 2788 1915 2787 2786 2785 2784 2783 51764 94235 55970 54331 2767 59345 6347 8453 898 829 9134 4097 2782 3043 2776 830 10681 832 5584 3576 1869 3725 7027 1871 6737 7029 5598 2034 1019 1017 1027 1965 55620 5753 8894 1968 5770 84181 51606 9820 6647 6648 4001 9817 302 64839 571 23657 472 59341 8649 6117 6119 6118 7099 10542 4194 8550 23643 253260 389541 28956 4193 57521 7322 6009 5052 4792 7709 5608 10524 7001 93661 2353 55860 55004 51164 1026 84516 2475 10671 1386 5594 5595 58528 5034 4683 10808 27000 338 26353 79109 259217 1410 116835 890 7266 8900 51182 573 3337 6767 51501 57805 9531 22824 6782 26277 25913 3310 65057 91582 7013 3305 7014 55615 9529 54386 10049 3308 8878 10111 4361 140801 64223 545 57761 672 3552 467 64121 4520 83667 4512 4513 4514 10670 153129 7290 10325 57634 81501 153222 90993 64764 148327 84699 10488 23135 51121 644 645 113235 23521 8091 493869 10897 140809 30001 2324 4501 4502 4504 1003 64061 10641 55364 1032 1031 2114 79594 22809 1054 56005 2134 8912 6734 6745 112399 112398 23334 3490 3009 3008 3007 3006 54205 3005 10266 55738 3024 440275 126374 23523 9812 652968 79726 213 8994 3068 115209 54468 10203 23043 4189 7466 84219 59284 96459 50488 9448 154743 9681 11015 8131 27244 55062 144577 27230 2880 2878 27429 79094 2882 29855 468 201163 79400 55466 7353 81502 3301 729438 1388 10985 55666 5520 10954 55033 10130 55846 4217 5241 2056 25842 6256 6649 5465 10113 4199 64344 23677 2099 4493 4494 6095 4495 367 4496 2077 81929 2908 4490 4489 318 2081 10106 4306 4499 10424 10587 9709 57600 55662 9973 54583 84560 7157 10072 133 23645 5175 9780 10061 9797 1460 3685 257202 116138 9570 11133 9588 1459 10935 26043 1457 9361 27102 58477 1663 1200 9429 5747 3336 2288 8204 10963 7296 100137049 7295 6464 4688 4689 51143 2877 2876 5586 2887 9045 1950 8454 8655 6233 1781 3320 1778 84962 5577 140735 7316 7531 10540 6818 8945 125965 5518 7311 80205 7314 6500 3313 10121 5566 11258 596 598 6774 9695 4323 84447 10728 11224 84335 25873 4697 768 84290 5563 824 826 6888 783 784 25828 6696 3339 335 6907 8648 10891 5931 653361 94239 1780 23054 1536 1535 25 1783 3791 54145 8331 8337 8334 8335 8535 37 8341 10013 8342 8347 8348 6045 8345 2113 648 8340 6015 23466 9532 9530 1912 1387 1911 8338 10294 80012 57332 84733 2673 85441 85236 8349 1639 6604 9575 9572 2938 8290 22872 2932 2940 811 2033 8370 2146 79813 343 10499 2950 3013 6197 6196 6195 3040 4208 255626 5599 5609 3021 6416 5601 7867 5602 7414 5606 3018 3017 3014 2309 79718 10413 9167 8841 474382 10919 815 8970 816 51726 128312 817 7094 818 25942 55766 8726 8968 23411 10525 1021 2539 5469 3678 1030 847 653604 4000 3484 9612 30827 9611 4736 23512 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME 389396 54490 79799 7363 7365 682 7364 7367 7366 54659 8714 54658 1244 574537 10720 54578 54577 54576 10941 54657 10249 1558 213 54579 1576 1565 6566 1571 219970 1557 1559 92292 590 123876 8824 133688 54600 1066 348158 341392 54988 167127 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 9575 1387 4297 406 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease 5436 5438 2549 5295 5439 10818 5290 22916 4686 2248 2255 2252 27006 5430 5431 2247 5432 5440 5433 5441 5335 2263 2251 5434 5435 5437 4893 6654 2254 8074 2249 2963 3265 2962 2246 8823 8817 26281 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids 23421 51143 401541 64105 378708 1780 79172 1783 83540 80152 8655 3619 6233 7321 64946 1781 25906 11065 8697 7324 1778 10393 29945 348995 29882 996 57122 699 51529 8881 64682 7316 27338 140735 119504 55746 246184 25936 9793 51434 51433 23332 6232 23279 79980 79023 54908 5347 22919 6396 5048 9861 5682 5683 151246 5684 9735 5685 5686 5905 5717 5518 5718 1062 5719 7311 7314 11047 5903 10213 5713 5714 7979 220134 5690 57082 5691 54820 5692 5501 5693 5694 5695 6249 5706 5707 79902 5708 5709 9212 5687 5688 5689 25909 5700 9183 5701 54821 9184 5702 991 5704 23122 5705 4085 701 81930 9232 84643 55920 3796 57405 7514 10403 80776 11243 23047 5519 113130 9700 23244 5525 23063 5515 5526 5516 5527 11004 5528 5529 91687 57551 79682 11130 332 2491 55839 8379 55143 9126 10735 55166 10726 79019 10274 8243 1063 1060 151648 5885 1058 79003 55055 81565 147841 348235 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs 140735 51143 3306 5241 829 3337 367 1780 2908 2288 10728 10540 3305 3326 10294 830 832 4306 2289 93661 3312 10963 1783 55860 1639 8655 51164 84516 1781 3320 10671 1778 10121 3304 11258 55466 3301 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines 317772 57492 86 1019 85235 8370 5931 94239 55766 55170 10498 8968 3717 3013 8338 595 55193 79084 221613 1788 51412 10196 92815 8969 54496 6601 6603 6187 55352 6602 3276 3014 6605 196528 653604 6604 10419 8331 8337 11091 8334 6595 8335 8289 6597 6599 6598 474382 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells 4893 25780 10125 3265 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins 999 5317 1828 1829 836 7082 1499 1830 100506658 1832 9414 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response 9682 165918 1642 7158 51035 25 54145 472 6233 7316 8341 8342 8347 8348 8345 8467 8340 9656 7334 10524 7336 9861 5682 5683 5684 5685 5686 5717 85236 5718 5719 8349 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 8290 5706 5707 5708 5709 5687 5688 5689 4683 5700 7341 5701 8370 5702 5704 5705 51588 7329 255626 7157 5599 8314 11200 10111 4361 3018 3017 3014 672 347442 5536 139425 29086 9025 2070 8924 51720 322 84142 9577 79184 2140 2139 8970 128312 9978 84295 580 9031 7468 23030 8451 8450 2138 3838 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation 808 10768 3708 3709 5534 4775 5530 5532 3710 4772 4773 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage 840 842 54205 836 317 331 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited 8772 7186 8795 8743 8797 355 356 841 8737 8717 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 8772 7186 8795 8743 8797 355 356 841 8737 8717 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis 3708 3709 5023 5024 9127 5026 22953 3710 6786 80228 84876 7222 7225 808 487 488 5027 489 6543 6546 5025 6547 490 491 492 493 6717 57113 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins 5905 7341 7329 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER 7316 5111 6119 10714 6118 51426 5424 57804 54107 5982 5983 7311 7314 6233 5981 56655 3978 5984 5985 7515 5425 5426 5427 3980 6117 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport 5687 5688 5689 5700 5701 4363 6048 5702 91445 5704 5705 26154 10956 8714 51009 1244 10058 10060 7415 10057 64241 64240 6400 22 215 5825 91319 6233 9619 5244 27248 7316 5824 368 21 10613 11160 10257 24 11194 23456 3767 23457 10349 89845 85320 10347 1965 8894 20 23 340273 10350 1968 64137 23461 5243 10351 9861 23460 8504 5682 225 5683 5684 5685 5686 79139 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 335 5706 5707 1080 5708 5709 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry 5868 7099 929 5045 1956 23643 2262 3480 221914 4691 9672 1524 6383 5869 10082 2239 6385 375790 2719 6382 3339 2817 5878 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease 219988 23644 1656 55802 23658 196513 27257 80153 25804 167227 27258 51690 54464 11157 57819 RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants 4893 3265 3845 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs 5058 5062 79784 5063 4627 5500 998 808 4637 2316 4638 10398 4771 3984 5879 103910 4659 2017 4628 4660 4629 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias 3767 6833 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD 27249 25974 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) 3162 114548 718 3326 953 4907 957 7295 4791 1511 4210 9051 29108 4790 10910 10628 5027 834 5025 3552 3553 719 3606 79792 5970 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA 23171 23259 57678 248 150763 254531 79888 30814 137964 8399 5320 5321 5322 10554 283748 10555 80821 5319 8443 84895 2819 100137049 26279 149998 201164 374986 81579 2820 55326 56894 56895 84803 253558 51205 22925 5337 200879 5338 64600 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 9738 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 22897 54930 5116 79959 80184 5518 93323 728642 7277 984 23354 22981 8481 114791 80254 85378 983 10426 121441 27175 55755 653784 54820 29922 10806 27229 440145 10121 10844 5566 55835 80097 55559 8636 11258 84131 4957 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm 2627 7852 2626 64321 6934 1499 4087 4088 999 4089 3170 8320 6862 145258 83881 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se 875 27232 51540 191 1491 4837 3176 4143 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors 4803 135 116 4914 117 4915 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants 2322 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K 79001 29914 154807 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib 3320 2064 11140 55914 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels 4233 4986 4988 7222 25942 3066 3065 2891 5775 5770 114787 2289 2904 6515 2903 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD 23169 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 9971 1593 9420 8644 8648 6256 80270 1646 1645 10499 1109 1582 1581 6718 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts 51302 11001 9971 1593 8644 8309 3295 9023 26031 8648 6256 80270 114876 9885 10499 114880 114881 1109 114883 570 6718 8647 10005 9420 10858 5825 1646 1645 5007 1582 1581 23600 10998 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 836 5062 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) 3777 51305 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation 4057 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 2247 5295 2549 5335 10818 5290 2251 23768 23769 23767 2248 4893 2255 6654 27006 2254 8074 2249 3265 2246 10817 5781 26281 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils 649 84695 4015 4016 7093 5118 4017 7092 84171 7837 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 2812 11069 7450 5908 2815 2814 5747 6714 7094 2335 9564 6850 1398 10235 10125 5770 150 152 3674 2811 2147 6464 2266 3690 207 2243 54518 7066 10411 4352 5906 151 1445 6654 5170 2244 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 3481 3479 4893 6654 3265 3480 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA 10714 5424 57804 23649 5422 54107 5557 5558 8454 6233 7321 25906 11065 8697 7324 6502 10393 29945 29882 996 51343 51529 8881 64682 6117 7316 6119 27338 119504 6118 246184 51434 51433 9861 5982 5682 5983 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 4176 2237 5718 64785 5719 8318 9837 7311 84296 7314 4171 11047 6500 51659 10213 5713 5714 7979 5690 5691 5692 5984 3978 990 5985 5693 51053 5694 5000 5695 5001 23595 5706 23594 5707 81620 4998 5708 4999 5709 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 1763 5111 1017 9978 5981 56655 5425 5426 5427 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 10499 367 8968 5585 3013 8338 354 255626 23081 3021 85236 8349 3018 3817 3017 54145 3014 653604 8331 8337 8334 8335 23028 474382 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 54567 3091 4343 192669 3280 23112 27327 26523 27161 192670 57690 595 861 3002 1950 1956 8454 6233 7316 113878 23220 92737 8788 1272 1840 11060 23493 6484 6487 9861 23462 5682 5683 5684 5685 5686 28514 5717 3516 5718 5719 2173 7311 7314 11047 6500 10213 5713 5714 7979 3955 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 4851 5687 5688 5689 5700 5701 5663 5702 5704 5705 23129 6868 7534 5045 207 1991 23385 8650 9978 83737 408 6772 83933 102 26960 6907 26508 409 94239 3714 55869 388585 54145 487 488 489 8331 8337 8334 8335 2324 51564 8341 8342 10013 8347 10014 8348 79885 8345 8340 4088 1024 1387 8338 9734 85236 8349 9148 142678 7088 7089 7091 4904 54492 57534 2033 5664 8370 9759 55851 83464 3013 255626 5584 100996717 7157 84441 9794 5870 6400 2683 3021 55534 56983 4853 5986 892 4854 4855 3018 1869 3017 3725 3014 23509 22938 7027 1871 10959 51107 51548 79718 1999 4242 100996763 388677 7029 10046 10402 8841 474382 8970 8850 128312 55766 8968 182 3066 3065 653604 23286 171558 2208 2648 9787 59 5087 10460 9612 9611 4192 4609 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway 2706 2705 2697 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD 6916 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 4803 396 4168 4804 4099 57142 387 4974 84894 INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling 3718 50615 6772 59067 6775 6774 3716 3561 6777 6776 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions 4690 89 23607 9863 55243 5295 84623 6711 88 81 5296 84063 4868 5290 5291 8573 87 8826 2534 8976 6709 8440 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud 3237 5979 5076 9353 3207 255743 3227 6495 2138 6299 2674 6092 26585 2296 8516 7481 3688 2668 10736 2303 652 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 35 3032 3030 3033 1892 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin 9314 23478 590 7349 43 60559 28972 3479 2641 1395 5122 9789 90701 3630 619373 3952 7941 2688 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 5929 80176 23194 50813 3091 136371 10324 10537 79728 55208 10920 28952 1642 23142 26094 54939 9655 23038 140825 23369 10489 54951 23363 54165 9306 149951 1161 80344 55827 23113 55832 84259 56929 79016 51122 200845 54876 50717 83987 150684 8816 90864 170622 10116 29099 8454 79269 51397 55884 55527 6233 23412 7321 56995 28991 80067 123879 8883 122416 51514 7316 23291 7322 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 114907 7314 11047 6500 10213 5713 5714 1026 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 8878 7347 123228 1643 672 9318 332 9978 8452 84078 1154 8835 5931 25879 7415 2873 64326 7428 6502 7323 6921 154881 79594 6923 4780 283807 26272 51088 9616 26234 6468 150726 55336 26190 26270 93611 127247 401036 79791 55294 51665 51666 7353 142686 142685 51676 142689 10238 55666 10517 8453 84261 80204 57542 64344 26224 4738 23014 54461 25793 11275 64410 222235 10072 54850 140456 140458 140459 90135 146330 140460 140461 26043 140462 54620 115290 7704 55958 8139 390594 139285 84961 2034 122769 9021 55175 27252 51130 9903 92369 126433 26259 201456 80028 144699 899 84861 26268 90293 84727 92591 26263 26267 53339 285231 89890 9820 26235 26118 8451 79176 26232 8533 8450 84085 4008 9817 64708 51725 9039 26249 11091 8065 10987 51138 140739 9040 10980 79754 84541 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 9021 6774 55620 5753 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria 3795 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production 1800 10800 2678 64174 57105 2687 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins 4836 811 5034 7341 23478 100128731 7329 9789 54431 7514 3309 6185 6184 6233 28972 3837 746 1603 7316 54344 8974 51726 402569 283208 5033 10525 3836 90701 10527 2923 5593 84061 7991 7311 7314 60559 22937 3839 201595 8813 3840 3703 3841 8818 5611 335 3838 10965 58505 1650 821 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport 4750 389203 3420 506 509 284184 64795 10873 3419 2271 3418 1537 54994 513 8802 514 515 80775 10131 3421 8803 516 2875 517 8801 518 2110 521 522 2108 57546 2109 55863 6233 539 79064 54539 91942 84701 23409 7316 90639 440567 23410 90624 126328 25994 135154 8402 125965 55245 7311 51079 644096 7314 3313 100303755 55744 6834 150274 80219 83733 10476 80224 100996939 4200 5091 347411 341947 27089 4694 54949 4695 4696 29090 51241 4967 10063 55572 25874 64777 4697 4508 3052 55101 4509 29078 192286 374291 10048 751071 10632 79751 4519 4512 790955 7416 4513 25852 4514 81889 4540 81689 285521 4541 28976 440957 4535 8604 4536 57128 90871 4537 4538 148811 9377 51295 152100 617 2739 100131801 8050 2395 28958 498 55967 55969 51300 4289 1431 84300 79944 9997 5166 119559 5162 5163 54902 5164 93058 5165 84233 5160 5161 51660 25880 7352 7351 23530 38 7350 54704 1738 1737 160287 54205 137682 10296 1743 80232 50 51204 9551 57001 9556 3939 7385 6341 7384 7386 7388 3948 7381 3945 79133 3954 5018 92259 4199 116228 4190 2954 4191 29796 1327 493753 6389 27109 84987 1329 1340 6391 1337 6390 1339 6392 1351 122961 1350 1349 1347 1346 1345 9167 291 4705 1355 4706 1353 51103 2806 4707 2805 4708 4709 55471 4700 4701 4702 4704 4716 4717 4718 10975 4719 10165 4710 4711 4712 4713 57226 4714 79018 4715 4728 4729 4720 84833 4722 137872 4723 92483 4724 4725 9481 4726 25915 55066 613227 9016 4731 728568 728294 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia 64241 64240 THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome 834 58484 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes 64061 37 2137 10954 2135 55033 10130 51726 9695 7094 56005 2134 10113 6734 6745 84447 7709 10106 55738 10525 6818 118 3068 2673 100137049 9797 4189 7466 6464 116138 9114 9570 9820 1639 11015 58477 2931 1663 55062 1200 27230 4000 10897 5526 5611 22872 30827 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade 10454 64127 11035 51231 1849 1848 1846 1845 4791 257397 8454 6233 7321 351 4790 7323 5970 7316 10133 8772 7186 148022 23291 841 8737 7322 8767 4792 5608 7334 7335 2353 8945 9641 5518 3661 7311 330 7314 6500 3654 3656 5594 1386 5595 5604 329 3665 10010 3551 29110 9261 6197 84166 6196 92610 1147 6195 4205 8517 4208 10392 79155 79671 7157 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 3725 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 6885 7098 7187 7189 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes 84699 5046 5045 344 8720 51360 338328 51129 4023 91289 55908 3990 116519 5125 64788 27329 337 26291 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l 79796 DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair 4913 79661 4968 55247 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE 368 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants 3815 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 2247 5295 2549 10818 5290 2264 2251 9965 152831 2254 8074 2249 2246 8823 5781 8817 26281 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 4784 51082 5440 4774 5441 9533 51728 27297 661 10623 171568 5434 84265 5435 55703 5437 55718 11128 10622 10621 4781 4782 6741 SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism 26227 10955 256987 29968 619189 113675 10993 63826 57515 5723 347735 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 5111 5928 91750 286826 132660 898 55957 26271 8900 5422 1874 7298 8318 1869 3065 7027 983 990 7083 5933 6241 7029 5934 1719 81620 4998 1876 1875 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation 3082 4233 6692 3083 3249 10653 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 6530 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 2247 2254 2260 8074 2249 2246 2251 26281 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis 10476 506 6907 509 8648 10891 6256 5465 96764 3418 10499 51422 513 514 23054 55902 515 516 517 23373 518 5564 27109 4208 521 522 2101 5571 539 6300 808 4508 1432 79718 5563 4509 5565 4209 64784 200186 5600 8841 23408 23409 2551 10632 56652 10651 125988 814 54927 10989 25813 23410 7019 51106 6742 84808 79135 11232 10498 55735 1387 5442 54205 64216 3054 7978 139322 8834 440574 23082 9551 211 84303 9556 5469 85441 133522 80205 3313 84833 4899 6648 4580 6604 53632 1386 9572 2746 9611 498 2747 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 197342 7516 7156 84464 5892 7517 5889 4683 63979 23514 80198 55732 79008 79728 580 641 10524 7486 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 348654 10635 5890 146956 9156 675 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids 1565 8529 126410 1555 57834 1553 4051 66002 131 1572 284541 11283 1580 1579 1549 1573 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 718 567 909 56253 56654 4068 5817 5819 89858 114836 910 2213 911 912 959 3803 3804 3805 3689 3806 374383 8778 925 10666 3802 285852 3386 3385 23547 29121 4345 10990 6402 3384 933 3383 10871 10870 3811 27180 3812 27181 353514 1525 124599 117157 342510 3820 7412 946 3821 7087 126014 100132285 340205 10219 146894 57823 10859 11024 120425 11027 11026 135250 131450 9436 9437 4267 3695 259197 79168 29992 29990 10225 89790 4277 54210 114132 51348 917 11126 11006 339390 100131439 999 2209 9976 100507436 80329 79465 3903 2214 3904 27036 79865 146722 975 10288 6614 196500 8519 930 81035 11314 3107 3106 3105 22914 7305 3824 54209 3134 3133 926 3683 945 3135 3676 915 916 3688 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function 5956 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential 338567 3768 83795 60598 89822 54207 3776 9424 56659 3775 50801 3761 10089 3759 3777 51305 8645 3770 56660 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency 56922 3141 31 5095 64087 5096 5091 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function 64220 7276 5950 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles 2327 2326 2328 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly 3320 3843 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 2538 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange 6119 7516 7156 6118 5892 5889 4683 3364 83695 1111 580 641 10524 7486 5982 5983 83990 84126 10111 4361 472 7979 1763 545 144715 80010 5984 5810 5985 5888 672 5932 5883 5884 116028 11073 5890 9156 675 6117 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type 51302 9971 29785 8529 8648 113612 120227 6256 5443 131 66002 10499 1545 1543 56603 1549 1548 1558 1544 1576 1565 5447 9420 1571 64816 54905 1557 1559 10858 1555 285440 1553 1551 1572 1562 1583 1582 1581 1580 1579 1577 1573 340665 1594 1593 1592 196 1591 1589 9915 1588 1585 1584 284541 5740 2232 2230 1595 405 112812 126410 57834 57491 4051 11283 6916 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea 6844 6853 6616 129446 5864 440699 25861 9381 27445 161497 124590 246213 829 51168 11344 8573 64072 8927 4647 53904 494513 3778 9750 3779 9478 259236 65217 23136 339768 830 117532 832 117531 25794 643226 286262 2036 10518 5357 53405 7430 10083 4627 64787 222662 83715 9132 80331 389207 2059 51475 5962 140469 6855 6709 490 4641 776 6711 783 5756 6804 9254 4478 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling 673 5501 8036 22808 5894 369 5500 7529 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) 4056 3248 240 22949 241 239 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 4750 7316 4289 64795 7416 4200 25852 10873 54704 4199 81889 54994 5091 347411 2954 1738 1737 160287 10296 2875 80232 5166 79018 3939 57546 5162 25874 5163 7311 5164 7314 5165 64777 3948 6233 2739 92483 5160 5161 8050 3945 51660 55066 10048 23409 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a 5373 CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism 378884 2584 51000 54020 132789 7957 2592 11081 10855 2588 6652 5631 6233 2597 266722 10861 9061 9060 132158 2132 2131 5634 7316 2137 3161 2135 23324 6677 56548 51363 729020 6483 6482 6484 6487 6513 2646 2645 135152 51071 5518 80201 126792 7311 7314 10090 3795 64711 6383 166012 10082 29940 6385 5566 6382 5507 8703 8704 4060 3340 8702 8707 8708 8705 4669 5210 5211 2023 5213 221914 5091 55276 10007 9672 4969 27087 2239 5207 5208 2027 2026 5209 10057 2799 5223 1514 5224 55576 8021 1634 3038 3037 3036 2262 5214 2331 6548 178 5230 1836 5232 9334 5549 9331 64579 5226 5834 2817 5836 7167 5837 9348 90161 6888 9917 5236 26035 5255 63827 5256 57818 5257 960 55790 9942 5261 79369 2719 176 64080 3339 113189 5260 10331 5567 6120 9953 5568 9951 8908 3099 3098 30815 5105 11041 5106 79586 64131 64132 11285 23563 10317 9957 9955 50515 6448 9956 8789 92370 9394 10327 9653 26007 23165 55501 222537 375790 4123 337876 9631 11261 7175 4958 669 83440 10690 28 4125 808 4126 348995 9883 6007 387712 6006 57122 347734 55746 3906 23279 79023 10762 6396 8692 7360 129401 51181 4927 10678 216 25796 8509 4166 5903 9688 23225 226 55706 229 23636 9972 8534 11097 23511 7086 8086 230 283209 53371 231 8480 79902 1462 2990 23553 83592 3373 26330 8372 112937 3074 2632 3073 3425 79411 411 2720 3423 92579 633 89944 1463 10675 60495 11046 92126 2582 130589 80146 2683 51084 55454 9435 5519 2998 5515 2997 5516 2992 10402 5528 93010 2203 2526 2525 2524 2523 2529 124872 2528 2527 26229 26503 9469 2539 2821 2538 23729 2548 284129 2542 221823 22934 3101 10894 54480 22856 57214 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants 5156 ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes 5111 7316 10714 11201 7311 7314 6233 5981 27301 5984 5985 5425 5980 10459 5982 51455 5429 5983 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex 5111 5928 91750 1874 286826 132660 55957 4149 7153 1869 3065 7027 993 990 7029 5933 5934 1875 4609 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type 166785 4594 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants 2322 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) 2720 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D 2799 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine 875 1491 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 7316 29126 5687 5688 5689 5700 5701 5702 5704 9978 5705 4751 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 10987 5706 5707 2932 5708 5709 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation 5617 8370 348 567 4057 9246 5071 55851 83464 3013 3630 23163 255626 2934 6288 5045 3021 4069 7045 9027 793 796 3018 6622 3017 54145 10098 6233 54959 2243 3014 1471 351 325 23385 9627 9445 51107 6653 23621 8331 3375 340348 8337 3015 8334 4240 8335 81619 23555 4878 474382 7316 8341 8342 8970 8347 8348 128312 8345 6478 8239 6477 7276 8340 6406 8968 26088 8338 3339 23062 85236 8349 7311 102 7314 653604 335 337 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling 5034 338 4547 1071 319 4018 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases 2534 2322 3055 6850 2323 3932 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex 7316 5111 6119 10714 6118 5424 7320 57804 9978 1642 54107 5982 5983 7311 57599 7314 8451 7398 6233 5981 56852 8450 56655 5984 5985 51514 5425 5426 5427 6117 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins 5687 5688 5689 5700 5701 9184 5702 991 5704 5705 890 8900 4085 701 9232 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 7316 27338 119504 246184 51434 51433 4751 9861 5682 891 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization 84570 50509 7373 256076 136227 81578 1299 1298 1305 1303 1308 1302 1307 1301 1306 1300 91522 1310 1286 1285 1284 1282 169044 1281 1280 255631 57642 1297 80781 340267 1278 131873 1277 1296 1295 1294 1287 1293 1292 1291 1290 1289 1288 85301 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates 51727 122481 203 204 158067 205 26289 4830 4831 4832 1635 4833 7296 79077 25961 7298 7295 56474 1503 50484 2987 10201 221264 2745 6241 1841 6240 102157402 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling 3082 4233 4893 6654 200958 3265 57610 10048 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 5111 7157 1874 2033 6790 3276 7027 983 2810 995 10498 581 1647 25946 7029 5933 5934 891 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling 2549 5295 30849 5296 10818 5290 5291 3667 208 2248 2255 2252 27006 2323 2247 2322 5289 2264 2251 117145 9965 54106 152831 5140 4893 9846 6654 57761 2254 5170 8074 2249 8660 3265 2246 8823 5781 8817 26281 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism 9390 93100 23057 54956 683 83666 92014 84875 23475 65220 64802 128240 4837 952 10135 4907 55739 349565 55191 27231 55328 160728 56965 133686 54981 54625 143 83594 79668 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 3688 5829 3611 55742 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication 5928 89 23607 9863 5777 55243 5295 84623 81 5296 84063 4868 5290 2185 5925 5291 4613 4343 192669 23112 27327 26523 27161 192670 57690 1009 9789 7410 7020 6233 27085 4790 8826 1500 79872 10399 2060 117581 5970 7316 3569 6667 9855 5817 5819 64398 4193 5339 3691 9743 9861 7074 5682 5683 5684 5685 283106 5686 5046 9159 5717 288 5718 977 5719 3655 1499 7311 7314 11047 10213 5713 5714 7979 7291 5690 5594 5691 5595 5692 5693 5694 5695 5706 5707 58505 54971 5708 5709 8440 821 5687 5688 5689 6774 5700 5701 50848 60436 5702 3914 5704 56288 5705 100128731 3918 999 23396 2534 6591 1508 5045 1514 6185 116092 94234 6615 6184 5315 10009 6935 93986 55810 687 9839 348262 746 1520 387893 1603 3611 9459 5781 55742 9069 81607 7841 5818 57863 137075 24146 7305 9073 9071 9074 9075 84552 2318 6251 23705 1488 9080 1487 53842 7297 1010 87 1008 1007 1006 283 1005 1004 1308 1366 1365 1001 1364 1016 1015 90701 1012 51208 7016 64403 961 49861 221935 80332 23562 29780 54751 88 253559 149461 26285 140885 92359 8935 3909 80149 54549 25945 3572 8728 28513 55423 5010 10326 55679 3703 10686 3987 3716 6597 50855 1650 26508 23478 5931 94239 8573 84612 5589 9076 3728 50649 1000 23193 10207 54145 1013 1002 3170 8331 8337 7750 8334 8335 1003 8341 8342 8347 8348 8345 8340 8976 8338 7122 9314 85236 8349 331 60559 998 54737 667 329 7088 23028 57531 8370 2146 6663 51129 2316 3717 3013 84231 11171 255626 5584 1495 3021 1460 7414 3018 1785 1459 3224 3017 3609 1457 2294 3014 27319 28972 56978 6709 10979 8289 127544 474382 6929 6711 5747 8970 6714 128312 5829 55766 9844 8726 8968 6938 23411 1793 7764 5879 29954 4690 3570 10585 7490 3066 3065 653604 2533 7408 3688 23512 4609 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A 7450 2159 2158 2157 8460 2147 8459 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins 5476 7841 79796 2683 199857 91869 2720 56052 440138 1798 79868 79087 29929 10195 79053 11253 9526 4758 85365 4247 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 3799 3895 89953 5879 64837 391 3831 387 147700 3798 998 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 55343 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 6119 7156 6118 4683 3364 83695 580 641 10524 7486 5982 5983 83990 84126 10111 4361 472 7979 1763 545 144715 80010 5984 5810 5985 5888 672 5932 5883 5884 116028 11073 9156 675 6117 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis 142 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium 10576 55212 117177 123016 10575 79738 166379 6950 7203 92482 22948 8195 84100 582 2847 583 54585 6608 585 129880 6753 27241 10694 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs 10163 147179 3071 5747 644150 10093 10006 10092 26999 10095 8976 10094 60 10097 10458 5879 10096 10810 10787 25 4690 7454 7456 10152 10109 55845 998 23191 5594 5595 71 695 51517 8936 10552 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events 317772 85235 8370 3190 11267 51028 27243 84313 55048 23165 128866 89853 3013 9631 7175 221613 255626 92815 8969 79643 8021 51652 440689 3018 3017 8331 8337 348995 8334 9883 8335 57122 5119 29082 55746 8341 8342 137492 8970 8347 8348 128312 8345 27183 91782 23279 25978 79023 8340 51271 10762 92421 6396 8968 129401 1052 8338 51160 4927 155382 93343 7251 79720 85236 8349 5903 9688 23225 653604 55706 23636 9972 11097 23511 8086 53371 8480 79902 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins 9212 5111 55746 7341 332 7153 7155 23279 79023 7150 55143 10762 23165 6612 6396 51588 129401 7329 9631 6613 7175 4927 10401 5905 8021 6790 5903 3619 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD 2729 2730 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis 4086 8861 4089 8320 6722 6862 23493 10524 23462 4208 2627 2626 3670 9464 1499 4303 2648 9421 11091 93649 150572 57057 6910 55897 6899 1482 51176 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 3684 10454 9450 30849 64127 10695 59307 11213 6279 11035 7100 1687 6271 671 51231 1849 1848 1846 1845 4791 257397 8454 6280 7097 6233 7096 7321 351 4790 948 7323 5641 10333 695 5970 7316 7099 10133 929 8772 7186 121260 5336 353376 23643 148022 23291 841 8737 7322 3689 8767 4792 5608 7334 7335 2353 8945 9641 5518 5289 3661 7311 330 7314 6500 3654 3656 5594 1386 5595 5604 329 51311 79792 3665 3929 81622 338 10010 3551 29110 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 1508 246330 2002 7184 9097 5599 9252 3146 6285 1326 5609 6288 1514 11274 466 6416 6283 1513 5601 9683 7867 9684 26052 2266 5602 4793 5606 1785 28512 57161 3725 57162 1759 2243 177 23118 121457 28511 1515 80216 54106 5519 1432 5515 1520 5516 5600 5528 5598 5781 2244 64145 6885 114609 7098 5775 7187 7189 81793 51295 8651 8411 4064 51284 80231 3663 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h 79053 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 9420 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 5442 64216 7019 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons 2706 2705 2697 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation 29935 10926 55388 23633 94239 23649 5422 54107 5557 5558 54145 6233 7321 25906 11065 8697 7324 8331 10393 29945 8337 29882 8334 8335 996 51343 51529 8881 64682 6117 7316 6119 27338 119504 6118 246184 8341 8342 51434 8347 51433 8348 8345 8317 8340 8338 3836 9861 5682 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 4176 85236 5718 5719 8318 8349 7311 7314 4171 11047 10213 5713 5714 7979 5690 5691 5692 990 5693 51053 5694 5000 5695 5001 23595 5706 23594 5707 81620 4998 5708 4999 5709 5687 5688 5689 5700 5701 8370 5702 5704 5705 3013 255626 3021 3018 3017 3014 3837 474382 8970 1017 128312 55766 8968 653604 56655 5426 5427 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation 84335 2033 3306 815 26353 816 1410 817 818 64223 3337 57521 3320 2475 3297 3281 1387 2288 10728 3305 3326 3304 3312 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins 4249 7341 2589 51201 54956 100128731 25834 83666 10610 84875 79844 5589 7329 25921 6185 23193 2530 6184 6233 2931 6733 11253 746 54625 51114 6732 1603 7841 7316 1452 51125 253832 6483 6482 6484 6487 84061 6480 256435 27090 55741 11282 11320 7991 7311 29801 7314 4245 4124 51304 3276 56965 201595 3703 143 2932 58505 1650 79668 4247 821 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 4067 3717 2057 2056 8660 6777 6776 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome 5925 85437 1655 7428 SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions 2263 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose 5346 10062 7376 6257 6256 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 1582 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants 5594 5595 5604 5605 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 4860 CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily 8370 1106 54623 84844 22827 94239 8175 6749 3013 11325 23451 6925 23350 255626 80349 3021 10946 4654 4656 11198 3018 3017 54145 3014 83443 8331 8337 9646 8334 8335 474382 6632 6929 51639 23168 8341 8342 8970 8347 8348 128312 8345 6628 8340 55766 8968 6938 6634 6633 10291 8338 10992 6636 10262 6635 6637 10523 10285 85236 8349 6627 6629 653604 1665 23450 84991 6638 9879 79577 123169 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives 59344 2877 2876 242 246 239 2879 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport 537 10539 94033 79689 113235 7018 3658 7036 3077 51310 79901 4738 55832 30061 155066 9114 8454 6233 9429 523 57192 525 526 527 528 7037 529 3163 7316 3162 127124 23545 51382 533 534 535 2512 48 3934 50617 2495 1356 26234 4891 51606 245972 245973 55240 9843 9550 7311 7314 6500 8992 90423 10312 9296 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium 403 27031 192668 84747 6102 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors 7022 7020 10765 4609 1026 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation 7186 84282 64135 57506 3551 4792 23586 1147 7189 4214 8517 89122 3146 7706 6285 6288 6283 4791 4793 28512 177 4790 351 28511 5970 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A 5687 5688 5689 5700 5701 9184 5702 991 5704 5705 890 8900 4085 701 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 7316 27338 119504 246184 51434 51433 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle 5058 28964 9497 200894 6510 23433 392 115703 54438 9815 10298 23092 143098 3728 144402 4983 857 9322 23229 8476 81624 23580 8826 55114 10395 6453 8874 7037 2909 10435 9578 128239 11135 8773 11060 9341 8976 57580 26030 9743 57584 10602 23048 394 7879 55240 55789 5062 55004 81839 23513 998 2040 23380 57120 85360 1080 2697 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription 117608 5928 640 5929 4336 79862 7621 9968 650 894 9969 896 340252 51385 902 171392 7633 5925 148156 23314 79943 7626 7625 7627 3280 126375 374900 55762 79973 7638 348327 7652 57711 55778 10224 25925 7422 163732 2593 221785 374928 200845 148103 3064 694 79755 55786 80349 79759 140612 2101 4149 158399 10432 7673 5494 25937 10914 169270 463 79744 619279 30818 728957 84449 7678 117581 8784 7692 7694 5275 7697 84701 7699 163227 163223 79088 84676 84436 84671 54807 163255 23269 59269 54811 55900 5054 8317 11059 80095 10172 7004 9668 7003 7005 10498 201514 94039 5079 115196 23493 51333 126070 7025 26974 65988 405 25888 406 728927 6515 9861 23460 5682 23462 5683 286075 5684 7039 5685 126068 5686 374879 127396 28514 2811 5717 51592 3516 55713 5718 10168 5719 1499 9464 114907 11047 84838 10213 26152 163081 5713 374655 5714 7057 7979 7291 57474 5690 91120 5691 7050 5692 169841 83744 5693 163071 5694 83746 5695 390927 147837 7067 5706 1998 5707 1997 84626 5708 80264 5709 51176 1750 26149 4851 5687 63934 5688 163087 5689 79027 144348 3958 5700 60436 5701 3726 84874 5702 84870 5704 80032 5705 93134 199692 163059 2891 92285 92283 256051 341947 5915 5916 146713 341359 3977 349075 2660 163049 163051 4839 163050 654254 901 30832 65243 7514 79891 2669 79898 4605 7534 23619 65018 100287226 388536 10308 124411 10781 10780 207 4852 10782 162966 7529 100289635 388569 388566 388567 1432 388561 3549 284309 284307 400720 58500 5600 10520 4878 3562 3559 3558 147741 1378 253639 284370 115509 90233 1392 57677 3329 79230 339327 339559 9978 146434 26053 83737 353274 158431 57209 91584 7710 387032 27153 7703 4435 219749 10370 220992 5775 7712 442319 7711 79818 10138 266743 148254 5308 90827 7728 2290 23429 2737 7743 148266 2736 148268 80818 342926 23660 6886 7733 54778 7738 23439 730087 7752 6662 7753 2063 441234 55634 51276 353088 7745 56729 7988 7748 7884 136051 10127 7761 7760 91975 7762 114026 3164 339500 4004 4488 100129543 129685 6872 7755 4005 22916 6874 7757 6873 55888 23327 7770 8861 219578 7771 7773 4686 90874 162972 148213 3174 6749 148203 51058 148206 6881 7525 6880 55659 5430 7766 6883 7769 5431 55657 6882 7768 5432 730291 8148 126231 5433 55663 6884 579 6688 6917 10794 10795 7539 7552 51497 7551 9975 11198 6875 285267 6878 285268 50484 4287 83860 8812 7556 6877 255403 7549 57615 2959 90649 2958 6879 100131827 7561 7565 2957 7323 122809 7567 7566 7559 2963 8409 2962 94115 2961 7571 7574 2960 29959 5436 7568 54925 6921 8431 5438 7582 6924 7101 7587 5439 6498 6923 7586 6497 6258 84108 8427 7594 4086 7469 7596 138474 4087 4088 8178 4089 9534 7592 8732 142 126382 84333 8731 112950 199777 7122 6829 64750 4091 4092 8396 84124 2904 2903 6827 54715 5196 9310 8463 9150 3930 9314 440519 10273 440515 1025 162239 181 54989 152687 51616 8013 8493 170960 57343 25920 125919 54457 147948 51224 147949 7936 9358 170959 26048 80108 80110 221044 6097 342132 285971 7182 4800 6096 4801 1876 904 4904 905 1875 4802 282890 344787 92595 80139 168417 1649 79175 93474 84527 84765 57154 121340 58491 58492 1437 27300 59348 147929 340385 84775 1327 2289 1329 1340 1337 1339 1351 1350 8312 1349 5519 1347 1346 1345 5515 5516 5527 5728 2625 5979 182 3172 613227 4609 639 4343 192669 23112 27327 26523 27161 192670 57690 595 861 6046 864 865 10135 7040 3845 5305 79047 7022 7021 83741 51741 339488 7020 284252 79837 7321 4790 25906 11065 8697 7324 10393 29945 29882 1436 996 27287 51343 51529 8881 64682 5970 27338 119504 1051 246184 1029 3569 6667 51434 51433 6934 23410 3654 6241 5170 6257 10971 51422 857 2810 5781 6628 6634 6636 6635 6637 6772 9377 3276 10000 7082 2744 7533 208 58484 808 10628 834 6502 4233 83439 6657 1749 4602 7248 7249 898 9134 2624 2623 84441 9794 2626 55534 4853 161882 4854 4855 1869 3725 4778 22938 7027 7029 10046 9021 1019 1017 1027 5770 3458 6648 10769 25904 7222 4850 57060 4292 472 94241 4848 4849 117584 10419 144715 8649 5810 10650 5932 5933 5934 5395 11073 55571 28984 55215 6117 6119 6118 10542 80196 4194 8794 8795 8550 8793 8797 4298 1121 253260 389541 85403 22974 355 28956 356 4193 246175 6830 57521 4300 1111 6009 4869 5052 64065 9656 5588 8445 9891 9099 5608 10524 27125 7486 55840 8851 9540 627 7001 5982 5983 2353 2645 1263 23368 55240 84126 27166 85456 55367 55004 835 839 29117 64769 23019 1820 1026 53632 2475 1386 5594 843 5595 5984 5985 55677 604 58528 5883 5884 116028 124446 54971 5875 5876 10397 9212 7156 5892 9337 4683 7159 27154 10848 79109 133383 4436 890 5300 8900 3486 3364 79370 7161 26155 995 57103 7832 84289 1616 57472 641 55615 51499 3630 9125 7862 5562 5564 2177 2176 144455 204851 1874 26013 56950 29883 11200 10111 4361 5571 7994 64223 7874 54541 1643 1763 665 545 5325 80010 1647 25946 133746 672 79733 387893 317 5457 84883 5458 9156 64121 5111 8621 23774 83667 81857 8738 91875 28996 4512 332 4513 147923 4514 143686 8626 6446 10670 83695 5371 63970 153129 580 112858 8106 581 3622 900 6720 51755 10325 51412 83933 10765 5978 80314 5443 1081 55170 55869 55193 6794 196528 8089 5467 54205 3815 7341 7376 7068 5241 6256 7421 5465 2099 7181 6095 367 4929 2908 9759 5468 7329 5914 2516 7157 1460 1459 1457 9441 51586 6714 6722 2821 83990 7296 7295 57678 2877 5579 2064 1956 6790 8454 6233 7316 7532 7531 79869 891 125965 5518 27165 7311 7314 6500 983 5566 55835 10018 27113 5366 637 5045 1514 1513 4697 1515 5563 10398 5565 1479 1478 9915 1477 8239 6696 4322 5105 9862 6595 7562 4297 6597 285676 6599 11051 6598 51585 6908 6907 10891 51593 5931 9739 54623 348 404672 7695 7576 94239 9070 65123 1107 57508 80789 26173 134353 55726 8189 55756 65251 155054 64859 26512 1108 23248 25896 80237 162967 79035 25 10302 9997 162963 79664 29101 22936 7581 81556 147686 6621 6619 7702 6618 9757 54815 6617 55656 79871 6940 23379 54973 54145 92105 84967 284306 51808 55174 57117 55197 53615 83640 58508 84524 9422 58490 8331 8337 8334 8335 1022 1020 8535 84246 4773 4094 197320 51564 7913 8341 23168 10013 8342 10014 8347 8348 6045 8345 79885 25799 648 8340 7528 84911 6015 23466 1024 1912 1387 1911 5451 5452 8338 9734 9443 51692 80012 57332 84733 9442 9440 23468 85236 6601 8349 6603 10155 9439 6602 6605 6604 9572 90809 57693 81608 79577 2932 10898 51230 55339 57459 123169 7700 86 4331 6932 2033 8370 51003 2146 79813 9219 9477 162655 4221 3013 90390 10025 4208 255626 5440 23309 5441 3021 2966 892 2965 3018 100506658 3017 168374 5816 3014 29028 5434 284459 5435 90317 5437 23283 155061 2309 79718 2308 10413 2968 121274 9646 2967 54487 284443 6910 90589 8289 2572 53981 9167 147694 2571 8841 1482 474382 80778 6929 147687 10919 90338 57492 100129842 10001 814 11335 4986 29894 815 8970 816 8850 4988 128312 817 818 22869 25942 90576 2071 90333 2100 285349 55766 1493 353355 2068 81856 8726 1490 8968 6938 100131980 23411 79788 283337 22835 3683 1021 90075 114787 80317 29079 2539 146540 84914 10978 84924 2538 57547 2874 2104 57541 7767 2103 3674 5469 3676 3678 90594 133522 1030 113835 90592 23067 146542 9282 847 440077 3066 1278 3065 1277 4303 653604 56242 57573 55422 147657 57336 84661 440073 10793 57335 2648 5888 11091 50943 6750 3484 9612 199704 632 389114 9611 51123 11105 23512 146198 8085 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation 9846 2322 6777 5781 2323 6776 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME 2686 445329 4363 124975 95 10257 7366 8714 54658 2952 1244 6783 2950 54578 54575 10 6818 6817 10057 1571 9 6822 27233 2678 54600 55748 9429 2944 2687 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np 55733 50846 3549 6469 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts 55746 29894 23279 22916 79023 10762 23165 1977 6396 4686 10189 129401 8189 9631 7175 51692 4927 10482 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 81608 57122 8086 53371 53981 8480 10898 79902 7884 55339 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B 4669 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 7157 25946 57060 1026 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 7157 25842 5925 4001 3009 3008 3007 7290 3006 8091 3005 3024 29855 23523 3159 57634 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 9397 7316 93343 7251 79720 137492 7311 7314 51271 6233 55048 89853 51160 155382 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 4913 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 2353 7514 2669 5979 10769 9915 4193 5594 5595 440073 146713 1387 341359 3630 1020 8851 405 10135 406 627 266743 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant 7450 11093 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation 146850 5058 9402 5294 5295 23533 5296 5063 79109 253260 5290 5291 1493 5293 4067 208 2534 55615 5879 7525 8503 1326 940 5518 941 5062 942 64223 117145 207 998 7409 2475 5519 10000 5525 57761 5515 5170 5526 5516 5527 9020 5528 5529 3932 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6301 79048 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 6160 6189 6161 6233 6218 51091 6217 6175 6176 6171 6170 6173 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 6235 22928 6227 6229 6228 3921 118672 6122 6124 6123 116832 6125 7311 6130 6133 6132 6135 2197 6134 6137 6136 140032 51121 60678 4736 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis 7316 7879 5868 80824 4843 26276 7311 1511 7314 2023 6233 5230 2931 5987 5594 3837 5595 57674 3836 6421 9146 51606 11151 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 3032 3030 1632 1666 33 34 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation 1294 649 3914 7093 3918 3909 7092 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle 5058 28964 147179 9497 200894 6510 5295 5296 5063 392 57381 9815 10298 23092 143098 3728 2631 144402 4983 4952 857 8476 81624 81704 8874 7037 2909 9578 128239 11135 8773 11060 91010 9341 8976 57580 7204 9743 57584 23048 394 7879 55240 7454 55789 5062 54874 55004 81839 23513 998 2040 85360 2697 7112 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 7316 5687 5688 5689 4194 1029 5700 5701 5702 5704 5705 4193 9861 5682 5683 7157 5684 64326 5685 5686 5717 11200 5718 5719 7311 7314 11047 10213 472 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 51230 5709 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus 23165 9631 7175 51095 60528 8021 11260 1653 348995 79897 9883 51367 11102 57122 10775 54913 80746 79042 51493 10940 339487 79074 55746 10799 10557 283989 283742 29894 1478 10556 116461 10248 51637 23279 79023 10762 6396 129401 4927 10978 5901 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 10898 79902 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions 7903 256076 783 9048 784 779 8912 1299 6900 1298 64096 4902 4684 2675 1463 5621 8913 5623 8911 375790 8128 2668 1286 1285 1284 1282 1297 131873 1287 1293 1292 1291 2674 782 785 775 776 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 2247 5335 2264 2251 9965 152831 2254 8074 2249 2246 8823 8817 26281 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling 127124 23545 537 51382 533 534 535 50617 3630 5770 3643 51606 245972 245973 1509 155066 9114 9550 8992 90423 5792 3416 10312 523 525 526 9296 527 528 529 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 2247 5295 2549 5335 10818 5290 2264 2251 9965 152831 4893 6654 2254 8074 2249 3265 2246 10817 8823 5781 8817 26281 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 5683 5699 5684 5687 5685 5688 5686 5689 5690 5691 5692 5693 5694 5695 5721 5696 5720 5682 5698 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling 8312 50943 861 84870 865 2099 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion 3028 54931 9692 55006 55687 84705 25821 64172 79693 54802 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression 4790 4851 1387 2033 4780 7975 4609 5970 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage 353 MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle 80179 22906 66008 89941 55288 55669 5910 9927 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport 9554 10113 10652 3998 2801 79090 2890 4905 23256 2153 966 9570 27095 81876 6811 10959 2157 10342 1453 51399 8775 7109 6399 5861 374 51128 126003 58485 51693 6396 122553 9871 5265 8774 9632 1075 23243 22870 2348 10175 10972 10427 7039 5537 9117 11196 64689 83696 55291 254263 25956 1522 55014 81562 63908 8615 149111 9919 90411 10802 10282 1294 26984 79748 10484 128637 89866 10960 22872 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis 5478 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle 1019 898 1017 5753 595 1027 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase 5537 55291 1017 55505 8607 890 54433 8900 10856 55135 1736 26277 25913 80119 65057 55164 7013 7014 55651 54386 7015 51750 23243 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) 7100 4615 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 1586 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate 1468 58472 7263 100131187 6821 23474 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 5687 5688 5689 144165 5700 5701 5702 5704 57154 5705 7855 7976 8321 8322 7474 8325 8324 2535 6233 7316 64750 9861 5682 5683 1856 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 23513 5714 57216 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 50855 5709 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism 2760 259230 94103 2583 2581 94101 80777 142891 4758 4759 55512 339221 9514 56848 57704 9517 5476 9217 123099 5660 7357 79642 9218 7368 6483 125981 10558 10825 6487 204219 8869 2629 8879 57733 221 222 410 412 5007 414 415 416 29956 10715 8705 4074 8706 130367 4363 112937 124976 3074 3073 79411 411 2720 81537 165679 81849 89944 253782 388931 1455 427 340485 8877 23683 29906 25865 79152 8560 347527 29095 25870 84002 285362 9334 9331 166929 64781 56624 9429 91012 55627 2524 55304 2523 151742 171546 153642 8611 8612 5587 2531 2717 53947 22901 79603 30815 8613 340075 6610 6609 55331 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) 10479 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance 22794 9939 65109 9775 1739 10921 55110 4116 7430 4627 7220 7222 7224 7223 7225 5962 4651 57113 1272 6712 4067 5588 8851 9861 7074 5682 5683 5684 5685 5686 5717 5718 5719 11047 10213 5713 5714 7979 5690 5594 5691 5595 5692 5604 5605 5693 6654 5694 5695 2043 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 219699 8633 3312 1630 9423 90249 137970 5578 140801 1981 6586 4753 26986 8650 7903 9978 91584 286 5576 27255 3673 8515 10752 5567 5568 6122 6124 6123 6125 6130 6133 6132 1605 6135 4893 6134 6137 1741 6136 51121 3265 6128 6129 5921 6142 6141 6144 22916 6143 6146 8861 6147 5293 6139 4686 6138 2902 6152 6155 6154 7525 6157 27330 6156 6159 6158 6164 6166 6165 7852 6168 6167 6169 23521 6160 6161 6175 6176 6171 6170 6173 6921 6181 6923 8912 8976 6093 2904 8503 1969 5664 1463 55851 83464 64283 4628 4629 57522 6456 1175 160 1460 79784 3685 161 163 26052 3690 1785 1459 1213 1211 1457 1759 4637 51107 4650 6709 27289 6711 5747 6714 9037 6387 6092 2668 4690 5979 116832 9353 9046 6464 23767 2674 3688 9901 9495 5295 5296 10818 5290 5291 6655 10451 2887 200916 5216 5217 9355 9045 8022 23053 23708 7410 6091 5335 26019 56956 2064 3670 1956 10109 23032 2107 9826 89884 65110 4440 6585 6233 3199 1287 3320 5361 2935 5364 6453 8997 8874 10552 7316 9855 80728 256076 23332 6230 6232 6231 6234 6235 10093 6227 10092 6229 10095 6228 10094 7204 10097 10096 1286 1285 1284 1282 288 7311 7314 27 131873 1293 1292 6383 1291 23380 5566 8440 5058 28964 388 389 5663 5063 23122 23365 3915 1299 1298 23129 23396 2534 3326 3912 10298 11224 25791 25873 6188 6187 6189 23385 51466 71 9846 10398 6386 2817 775 10048 776 5781 9349 6191 6193 7305 6192 6194 54209 783 784 56924 3921 9475 1297 8829 102 4313 1742 4318 2197 8660 140032 6201 1212 6203 6202 57144 10570 375790 10371 56896 2242 6210 57556 10507 5532 6237 5788 51065 25 80031 5362 5365 6205 9723 6204 8218 64218 6207 971 6206 6209 10154 3672 6208 6223 1809 6222 8482 1400 6224 1808 55558 2886 6218 6217 4756 782 785 3984 3985 103910 1020 4233 2549 6478 9048 779 6477 6900 64096 4902 4684 2675 5621 8913 5623 8911 60 24137 998 284217 22885 2676 3897 285220 2932 3785 30011 3786 3680 6708 10627 100133941 2596 6710 4897 8453 148738 57453 57698 5649 2045 2044 2042 2041 5786 116986 2051 2050 2049 2048 2047 2046 8828 56963 10486 10487 8986 8128 6324 6323 6197 53358 6196 11313 6195 6331 6330 6332 6335 6334 214 9252 6326 8506 6328 285643 6327 6329 57731 6336 84448 7436 11280 59277 220164 55800 1943 287 1942 51332 1949 1948 1826 1947 1946 55816 1945 5598 1944 85358 23114 2909 1600 55715 1641 9260 284656 5909 285704 3983 7094 1796 1793 5879 387 3674 3678 5062 55740 1072 7408 4478 4736 5306 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins 7341 6045 648 6015 7703 1912 1911 7329 80012 57332 84733 8535 1789 1788 1786 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization 58494 8076 10319 1311 650 4148 8082 54221 4038 5802 7040 1287 50509 8974 10491 256076 5054 23127 10536 81578 871 283208 5339 7837 5351 3691 3689 5352 5033 8985 1302 1301 1300 55214 4015 3386 4016 3385 4017 64175 1286 26577 1285 1284 1282 3384 3383 169044 1281 1280 255631 57642 977 5479 3655 5118 340267 84171 131873 7412 1296 1295 7057 9644 1294 8038 7087 1293 6383 1292 1291 6385 1290 1289 1288 85301 84695 6382 79709 4060 3695 5034 50848 5663 3914 1215 3915 3918 1299 1298 4323 5654 9672 999 4324 4325 10893 4326 4327 6868 3911 3912 9510 7177 91522 634 5155 92291 2 85007 9507 1509 1508 5578 649 1504 6650 5045 1514 1634 1513 1511 80781 147968 3817 2331 3818 26254 1991 23385 1515 10753 84290 7077 50859 7076 222663 440387 1520 170690 823 824 825 826 827 170692 84570 5340 440854 388743 831 836 7373 9313 136227 7093 2335 7092 682 63827 1305 87 1303 960 726 4811 80274 1308 1307 1306 8751 6696 8754 3673 176 3339 8515 1310 56999 64386 961 11096 5650 11095 4320 11131 4321 164656 4322 1297 101 102 23473 3909 4312 5644 4313 8728 11132 5645 4314 4316 1605 4317 4318 4319 3684 8573 375790 3791 3672 51399 5154 4684 284217 3680 1462 4052 7043 4053 4054 7042 633 8425 1463 5175 3693 3694 3685 2266 3690 59277 2243 27302 3696 7448 2244 137868 8785 10516 84467 2202 2201 7276 2200 30008 8200 54829 3681 3682 3675 3679 1821 83700 3687 7143 3683 7148 2006 1838 1837 1834 4680 652 3908 140766 2247 8910 3913 9508 3910 9509 22801 3674 6641 3676 6640 3678 3371 4593 1088 63923 3381 1756 655 1278 6645 1277 1758 9378 780 1404 4237 4238 4239 7402 2199 22795 8516 3688 2192 4921 6443 6442 6445 4146 6444 6678 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance 5928 23421 10714 5424 57804 401541 5931 64105 54433 94239 23649 5422 378708 79172 1736 5557 5558 55651 5430 5431 5432 5433 80152 55505 8607 54145 64946 8331 8337 8334 8335 6117 6119 5436 6118 5438 8341 8342 5439 8347 8348 8345 8467 8340 4869 8338 7486 23243 5982 5983 5537 55291 2237 85236 8349 201254 57082 55135 5984 3978 80119 5985 55164 8290 7015 8370 890 8900 26277 1616 25913 65057 3013 641 7013 7014 54386 546 55320 51750 51773 55355 255626 11339 387103 5440 54069 5441 3021 3018 3017 3014 5434 1763 5435 5437 63922 79075 79991 80169 474382 100134934 54921 91687 5111 79682 8970 1017 128312 2491 55839 55766 55166 79019 1060 1058 5981 10856 5425 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade 3684 10454 9450 64127 59307 11213 6279 11035 6271 671 51231 1849 1848 1846 1845 4791 257397 8454 6280 7097 6233 7096 7321 351 4790 948 7323 10333 695 5970 7316 7099 10133 929 8772 7186 5336 353376 23643 148022 23291 841 8737 7322 3689 8767 4792 5608 7334 7335 2353 8945 9641 5518 3661 7311 330 7314 6500 3654 3656 5594 1386 5595 5604 329 3665 3929 10010 3551 29110 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 26052 2266 5602 4793 5606 1785 28512 57161 3725 57162 1759 2243 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 5781 2244 6885 114609 5775 7187 7189 51295 8651 4064 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 55802 5393 23016 51010 167227 51013 207 7529 118460 22894 56915 11340 54464 9261 23404 54512 677 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism 23659 57153 9791 23259 57678 5295 84879 58488 5296 150763 5783 50640 5290 50487 5291 151056 10390 137964 9600 114884 80736 80339 1040 56910 117245 56994 10554 57605 10555 8904 54979 5130 8760 10162 114879 123745 8821 171586 84895 55361 114882 85465 2819 5920 5305 284161 79837 66036 54545 55697 8871 8867 5289 8897 8898 54893 133121 388121 81544 81846 23396 3631 3635 3636 55613 200576 56623 55300 84725 22908 7179 8776 4534 5867 10908 51763 5868 126282 5286 5287 5288 25816 5294 30849 59339 59338 5297 79626 5298 5293 660 4952 65977 375 6305 377 23533 80230 8396 375775 8394 8395 8503 90809 9107 146850 27124 9110 9108 9896 79153 51552 8895 9468 26279 1460 10809 590 23446 126969 1459 201164 1457 81579 2820 55326 56894 57104 56895 51365 51573 11343 6901 253558 158835 22925 200879 56261 63874 64419 93492 64600 57110 204962 27132 23171 1103 79887 248 23175 255189 254531 79888 283871 30814 5728 10423 8398 8399 64850 5320 5321 9489 5322 255043 1120 9362 283748 80821 55500 114971 57664 55224 5833 5319 1119 8443 64900 3032 3030 22874 79143 22876 55750 100137049 149998 122618 10400 54947 154141 54477 9926 43 9663 374986 8694 129642 23760 23761 162466 23646 84803 84649 54675 347516 8605 51205 5337 11145 5338 81490 83394 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus 124512 8341 8342 3021 8970 8347 85236 8348 8370 128312 8345 5620 8349 3018 54145 5619 3017 8340 3014 7290 6732 132243 10361 255626 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function 145226 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 23220 4361 3661 3428 51428 340061 147945 11277 197358 2547 5591 7520 29110 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels 3768 3761 3759 3770 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B 120227 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 104 164668 403314 200315 339 9582 10930 27350 29974 103 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE 7098 148022 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 19 335 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis 2161 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 129446 440699 25861 9381 27445 161497 124590 51168 11344 64072 8927 4647 53904 494513 9750 9478 259236 65217 23136 56656 339768 120065 117532 121275 117531 120066 25794 283365 283310 390883 643226 390882 340990 390649 286262 390648 375611 5949 3781 2036 124538 4354 388531 10518 283111 5357 4991 53405 4992 7430 4993 10083 442184 57053 442185 4627 64787 442186 222662 79310 83715 79317 9132 284433 80331 341799 389207 5957 2059 219954 51475 219952 5962 121130 140469 79541 6855 79544 7804 54795 121364 125963 125962 4994 79549 4995 283694 4641 121129 133060 5726 219965 29850 130075 219960 390431 390433 442361 390436 390437 390439 341418 1259 79334 341416 79339 219959 338328 219958 219957 219956 283162 138804 65055 138805 283160 138802 5588 138803 390441 390442 390321 390201 54884 390323 390445 390326 390327 144124 254973 144125 79324 10988 283159 219968 127608 219865 219986 219983 219982 390892 219981 401994 401993 401992 259289 285659 259287 259286 259285 81309 79473 81797 390538 7932 219858 259293 259292 219875 259290 219874 219873 219870 259296 259295 390429 79346 79345 338 26188 81300 26189 50700 219869 347168 26716 286365 283093 283092 3778 347169 3779 138799 390113 3000 134083 391211 392309 150681 338674 338675 340980 2652 283189 219417 219438 219437 219436 26707 5578 219432 219431 126541 338662 403282 403284 127623 79823 254879 283297 219429 255725 284383 54429 219428 126370 219447 390271 390151 390152 391121 441308 390154 390275 390155 441669 80835 390157 390036 80834 390037 390038 441670 158131 138882 138883 138881 23538 390162 5475 219453 390167 390168 347468 8630 219469 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 109 391114 219473 390148 79501 286362 390072 390195 390075 3759 390197 390077 219487 390199 10170 392376 9249 390078 390079 219484 157506 219482 392138 127385 5406 143502 119764 8608 119765 143503 81050 390081 390082 390083 390084 6121 131890 26687 119749 26689 55584 402135 219493 23173 81168 81285 9626 392391 81282 392390 504190 6011 8573 390174 8861 390054 26533 256892 390058 26532 390059 26534 26658 26539 26659 26538 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 81061 2774 390190 390191 403274 127062 403277 403278 127069 127068 127066 127064 403273 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 119679 2914 390093 403253 6295 392392 441608 403257 6010 391189 3292 26735 9227 128371 26737 8590 128372 391190 196335 391192 346525 391191 391194 391196 391195 403244 128366 128367 128368 128360 119774 1262 119772 1260 26740 403239 346517 79490 9397 1258 81328 120586 83756 256148 81696 81697 50831 9254 50833 50832 50834 50837 8387 50836 8388 50839 3949 50838 8386 8383 81318 57016 79482 81448 81327 81442 50840 132112 393046 8390 8392 122742 26494 26493 401427 4836 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 1879 122748 127074 341152 256144 127077 283617 120796 81469 119694 119695 120793 81466 282763 81341 343563 119692 2979 387748 2978 344892 79290 79296 135924 2934 79295 2986 26595 26476 284532 125958 285440 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 6709 55937 121214 158835 26692 402317 26693 81399 26333 26696 26212 26211 81392 388761 2779 343406 6711 26341 51109 7276 5756 6616 2911 246213 151056 3710 9355 5330 5950 5948 1109 4035 5947 4036 6804 6383 10082 6385 6340 6382 6844 6853 6337 5864 6339 6338 221914 9672 346562 2239 611 53630 2262 255022 119395 2817 776 57101 83875 2342 783 2339 145226 2719 3339 26020 335 336 337 8644 5145 5158 344 5148 345 348 29967 375790 5959 5956 808 490 2792 24 6017 2784 51764 9187 829 2782 830 832 6324 64220 6330 6335 6326 6328 6327 1645 4023 1208 4478 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence 7316 1019 1032 4194 1031 1029 2114 6667 5925 2113 4193 4343 3397 192669 23112 2077 27327 26523 192670 57690 1021 7157 1030 7311 7314 1869 6233 1870 7027 1871 5594 5595 7029 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 5567 5578 5568 6092 5566 5576 5532 9495 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib 3320 2064 11140 55914 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants 3815 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation 199857 2584 5373 79868 29929 79053 375790 4758 4958 2592 11081 9060 2132 2131 5476 54344 79644 9526 6487 116150 2673 126792 4166 56052 7057 56667 3955 6383 10082 6385 6382 4060 4851 1462 79796 11093 3074 22845 3073 2720 633 221914 1463 9672 4969 10675 4351 2239 9510 2582 130589 9507 2683 1634 4853 4854 4855 91869 2262 2331 1836 5549 11253 170690 2817 7841 170692 10020 5236 145173 57188 2591 143662 10417 118430 63827 10418 1798 170689 171019 54437 26229 9037 4582 5199 4583 4584 7058 2719 4585 4586 200958 176 9469 157869 113189 3339 29954 85365 727897 56999 29071 140766 11096 80070 79947 10585 11095 9508 9509 10071 94025 339366 221981 140453 79875 81794 4588 55901 440138 11041 4589 81792 9215 283463 79087 55624 9719 56913 394263 1605 8813 11173 10195 11174 8818 80731 54507 11285 92949 170691 22856 4247 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production 4843 3837 3836 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins 23479 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot 5340 5345 3273 6281 5054 5271 5269 5327 5328 5329 5055 5270 302 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic 140735 51143 51560 2589 25782 829 8398 2590 636 23299 5321 1780 5050 5049 10540 830 832 5048 93661 22930 22931 1783 55860 5870 1639 8655 51164 84516 1781 56894 10671 1778 10121 11258 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake 10062 29116 7376 6257 6256 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs 192669 999 23112 27327 26523 27161 192670 57690 4613 4609 4343 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 2262 221914 9672 6383 10082 2239 6385 375790 2719 6382 2132 2131 3339 2817 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism 339896 440 2806 2805 443 10165 339983 8604 374569 2346 10003 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 91603 4331 50813 9716 902 404672 10920 1642 7507 1161 5430 5431 10450 5432 2873 5440 5433 5441 6917 2966 2965 7874 6233 5434 5435 27339 5437 56949 2968 2967 1022 9318 57461 7316 5436 5438 5439 2074 9978 2071 2068 57654 7311 7314 8451 8533 8450 64708 10987 51138 10980 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway 7316 80824 369 152559 5778 1844 1843 1847 1849 1852 1848 1850 1846 5518 4140 7311 7314 6233 5037 6300 7529 673 11221 5594 5519 5595 4893 5774 5604 5525 5605 8315 5515 5526 5516 5536 5527 3265 5894 5528 5529 8844 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells 7316 9402 6774 5295 5336 6714 5290 5291 3055 5293 1435 4067 2534 146433 8563 139716 7525 3635 3845 3636 867 6772 6464 7311 7314 6233 9846 6654 1436 5781 DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle 1373 5009 383 162417 445 435 57407 10166 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 92715 285381 89978 120526 1938 1802 51611 1801 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC 10071 94025 140453 2591 143662 4588 118430 4589 56667 283463 394263 4582 4583 4584 4585 4586 200958 727897 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) 3425 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 3162 4780 7975 81502 571 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants 6934 1488 1487 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 83401 10005 3295 60481 6342 215 3992 2180 9415 64834 30 54898 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System 5928 640 5929 6279 6271 200845 56259 80349 6280 25937 7097 7096 1870 920 5641 6810 8405 84676 11059 7004 7003 7005 5079 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 114907 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 51176 5687 5688 5689 5700 5701 5702 5704 5705 11340 23404 5980 10459 54512 51455 5393 7534 81035 23016 51010 51013 207 7529 118460 22894 56915 1378 9978 83737 11127 5567 5568 54778 8452 4893 84078 3265 5294 718 129685 6872 6874 6873 23327 5293 6749 6881 7525 6880 5430 6883 5431 6882 5432 8148 5433 6884 6917 7498 51497 11198 6875 6878 83860 8812 6877 6879 7323 2963 2962 5436 6921 5438 6924 5439 6923 7469 138474 8178 6396 6829 64750 6827 8463 9150 10273 1025 51616 25920 54457 51224 7936 904 905 1875 57154 9246 3551 51191 1147 8517 7318 3309 6456 1175 6890 6892 160 6891 161 64167 163 51752 26052 2266 1785 1213 1211 1759 2243 5519 5525 5515 5526 5516 5527 5528 5529 2244 10438 5728 5394 10200 27071 26191 4794 3902 5966 972 5795 6494 23108 3688 4609 29126 5777 5295 3091 5296 5290 5291 4613 4343 192669 23112 27327 26523 27161 192670 57690 595 7321 4790 11065 8697 7324 10393 29945 29882 996 51343 51529 8881 64682 5970 27338 246184 51434 5336 51433 6934 8767 9871 7334 9632 7335 10427 8678 5289 55824 22863 5170 5894 58505 821 2280 100128731 917 6850 51422 2209 1380 2534 2214 975 89122 4615 3146 6185 4793 6184 23118 3107 3106 3105 746 1603 5781 10053 22914 9402 3937 7305 3824 54209 162 51128 164 6885 3134 3133 8673 8907 8905 7189 84061 130340 6772 1174 3135 7991 10802 201595 10484 10000 3703 3716 8651 1650 30849 5534 567 208 5530 5532 5788 7415 4791 7428 4207 808 6502 5908 154881 7320 4780 23608 7975 6478 151888 7325 8764 6477 131405 283807 221687 79654 26272 51088 9616 90678 7317 56658 7319 10533 3093 26234 22888 7332 9870 6468 7336 10425 150726 64718 118424 83439 23295 55336 4602 7327 7326 26190 9867 197131 7328 26270 4734 24137 10422 1062 64837 54926 9520 26153 65264 10193 10075 93611 147700 998 127247 401036 79791 55294 55585 57520 51665 89910 22920 7337 51666 55905 26091 63891 63893 142686 57531 29127 142685 55236 10112 3659 51676 142689 223082 9371 10517 22954 9493 8453 91694 10293 9666 51320 84261 80204 829 57542 51444 11146 135892 55008 6047 6049 26224 23376 23014 54461 5071 81930 29116 57674 143279 84643 25793 830 84231 832 11275 3796 9320 3797 55819 64410 90025 3831 222235 3798 84937 3832 3799 140691 51465 54850 140456 6400 140458 90933 3835 140459 90135 285643 25897 25898 9690 146330 140460 3725 140461 140462 255488 114088 54620 23352 868 56992 8916 115290 6737 7704 55958 89953 8139 390594 11004 127544 55284 27246 84961 8924 122769 2034 8925 9021 64320 1019 9354 81559 55175 84708 7174 27252 51130 642 51132 26046 9903 4591 25847 158506 92369 55182 126433 26259 64219 7064 23304 201456 5879 80028 144699 899 84861 92912 10477 26268 7879 55070 90293 84727 92591 26263 26267 53339 5062 3123 3122 285231 3120 89890 55740 4012 9820 3119 3118 26235 26118 3117 3115 79176 3113 26232 55521 915 27040 84085 916 4008 9817 9398 51725 2533 9039 3127 3126 25831 3125 26249 7408 8065 3702 55658 140739 55176 9902 51619 9040 5721 29927 5696 148581 5720 79876 79754 23480 5698 84541 5699 9730 9554 154214 50489 151636 10952 80176 23194 9604 136371 10324 7220 4627 4292 5395 7099 929 80196 4298 8888 23643 4068 253260 85403 5971 114836 2213 6830 959 4300 7322 6712 997 10892 3689 59067 4067 3221 84433 3112 5588 4792 3111 10235 7709 3109 3108 10125 8915 27125 55840 1075 93661 5429 5982 23308 5983 2353 8832 3384 3383 55860 1512 1510 11201 1519 8722 3394 115650 10120 51164 7412 83547 84516 10437 53632 5906 2475 27301 10671 10673 60468 5984 5985 55677 604 5493 6654 79109 991 4436 55615 5562 5564 3635 144455 5571 64223 57761 79733 80380 9020 467 9156 5111 57379 11119 11118 696 56244 11120 10385 153579 10384 79908 5476 23533 8503 11069 5930 57630 5478 3693 1460 3685 1459 117145 1457 25780 4775 6786 80228 84876 3727 2354 4690 4688 5981 4689 10987 5425 10714 3708 51143 3709 3710 10489 5579 5335 8454 8655 6233 7409 1781 1778 695 7535 140735 7316 7532 909 56253 56654 5817 5819 89858 8773 23291 910 911 912 3803 3804 3805 3806 374383 8778 10540 925 10666 3802 285852 3386 4751 3385 23547 29121 4345 10990 6402 8945 933 10768 10871 10870 3811 7454 27180 5518 3812 27181 353514 1525 7311 124599 7314 6500 117157 342510 3820 946 3821 7087 126014 100132285 340205 10219 146894 10121 57823 10859 5566 11024 120425 11027 11026 11258 135250 131450 9436 9437 5058 4267 3695 259197 79168 6774 29992 29990 10225 89790 5063 4277 6048 91445 54210 114132 51348 114876 11126 11006 10956 339390 100131439 999 9976 100507436 80329 79465 3903 51009 3904 27036 79865 146722 10288 6614 196500 8519 118788 930 1509 1508 940 941 1514 942 1513 50852 1515 51466 5563 5565 1520 10613 9341 10331 6595 4297 6597 6599 6598 3932 6908 23476 5931 54623 653361 94239 9070 1780 23054 1536 1535 22976 1783 91319 54145 948 58508 1445 375 8331 8337 8334 8335 10333 4772 4773 5133 4094 10538 5977 8341 23168 8342 8347 8348 8345 3565 8340 11160 3662 79447 1387 60 8338 605 2923 8110 6778 79139 85236 6601 8349 2956 6603 29760 1639 10616 6602 142678 6605 6604 1050 22872 79577 2932 30011 123169 146850 86 811 6932 2033 26039 8370 2146 6760 3013 4360 255626 5440 5441 1326 3021 11314 3018 3017 3014 5434 5435 5437 10413 9646 8289 474382 6929 27248 57492 5909 8970 128312 55766 29851 1493 30835 8726 8968 926 114609 9274 3683 9275 945 7403 973 974 3676 8193 653604 10411 84661 11091 23512 8085 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins 3248 240 4048 246 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases 7316 64127 5728 84282 2099 8737 64135 8767 57506 23586 7187 7189 7415 387 8517 89122 10392 79155 7157 7706 80124 10318 79931 161725 55593 7311 78990 7314 55432 79589 55611 54764 6233 56957 7321 23252 983 324 7128 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement 717 1675 78989 3004 712 716 629 718 721 2220 1401 8547 10584 2219 4153 713 5648 714 715 MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction 3784 4632 89 4633 4634 3708 4635 3709 4636 7125 10174 493829 59285 7134 7136 7135 3710 7138 7137 7140 7139 93408 859 7273 2259 2258 2257 2256 140465 7169 7168 29767 476 29765 10060 10008 477 29098 478 29895 1760 309 8291 10580 53822 25802 1674 53826 58498 4703 7220 23630 3741 53828 25937 480 1193 30818 481 2281 482 483 486 301 7431 3767 6263 6262 10142 6261 8654 10768 9424 5350 3775 10089 444 5348 5349 10345 5566 6588 5058 2977 2983 2982 4842 8645 3770 56660 338567 204851 83795 60598 89822 54207 3776 56659 50801 80333 30819 10398 3750 3751 3752 30820 4878 775 28996 783 88 3761 3759 7170 7171 1066 3768 3672 808 487 488 489 6543 782 6546 6547 490 491 103910 492 493 6717 59283 27092 8912 8913 8911 29766 217 9254 59284 10627 6324 6323 4629 6331 6330 6332 6335 6334 2626 6326 3693 6328 6327 6329 7414 6336 11280 55800 4637 4638 6910 1482 815 816 8850 817 7094 5829 818 6786 80228 84876 4880 4881 4882 4311 10699 5062 3777 1756 51305 4606 4607 3753 3757 4604 9992 302 800 23704 8557 4621 4624 4626 7111 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs 5295 5296 10818 5802 5290 5291 57498 3667 1108 51231 1849 1848 135 1846 1845 5335 5899 25759 6014 6016 5603 6300 5900 5800 6236 3399 4066 8941 8061 10221 5125 4664 4665 1020 1959 3398 23237 1961 1960 7425 429 6457 2549 4915 8851 2904 627 7074 2353 5046 5518 25920 2889 673 5906 5594 1386 5595 1399 5604 5605 6654 4916 4908 10817 6774 2033 3726 3397 9261 6197 6196 53358 6195 4205 4208 2002 9252 6456 5045 1175 2152 160 466 161 163 7867 26052 1958 4914 1785 1213 1211 1759 10126 7529 4803 5519 1432 1795 4209 5515 5516 5600 5607 5528 5598 5781 7166 6714 6446 1398 581 6938 6722 3727 5879 2354 387 6464 116 117 5898 5978 3400 4893 8660 3265 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery 6191 6193 6192 6201 6194 6203 6202 6230 6232 6231 6234 6235 6227 1915 6229 6228 6210 3921 51065 6205 6204 6207 6206 6209 6208 6223 6222 3178 6188 6224 6187 6189 6233 6218 6217 2197 140032 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events 111 112 156 113 114 5137 814 115 5153 815 5136 5613 816 817 818 5321 196883 5582 5580 5573 5575 5576 107 108 5567 5578 109 5568 808 5594 10645 84254 5566 3838 26960 5577 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors 3354 147 1132 148 1133 3352 3274 3351 3350 1129 11255 1816 1815 1814 1813 1812 4935 1131 150 152 3358 3357 3356 9287 3363 151 3362 3361 3360 59340 153 154 155 3355 83551 134864 319100 3269 134860 9038 1128 146 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate 6657 9839 5453 5015 79923 5460 6656 25925 7546 5080 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor 7450 2157 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors 567 23165 9631 7175 55690 11168 1104 6233 8815 375 348995 920 9883 57122 7316 55746 292 6921 293 6923 23279 79023 10762 4869 6396 129401 3836 4927 3159 9861 5682 5683 5684 8945 5685 5686 5905 5717 5718 1025 5719 5901 5902 7311 7314 11047 5903 6500 10213 5713 9688 5714 23225 7979 5690 5691 55706 5692 23636 5693 9972 5694 11097 5695 23511 8086 5706 53371 5707 8480 79902 5708 5709 904 5687 5688 5689 5700 5701 5702 5704 5705 3055 2534 5478 7514 940 1175 160 8021 161 163 3837 3105 1794 291 10053 162 9978 164 9844 926 8907 5879 8905 51606 130340 1174 5062 8065 3932 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 5432 5436 5440 5433 5441 5438 23405 5439 5901 8575 6895 144233 57510 5434 29102 192669 5435 5437 26523 27161 192670 54487 5430 5431 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins 808 5609 5045 5604 10015 5605 6416 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response 840 842 56616 51074 836 55075 331 5594 5595 54205 317 22900 57099 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema 2161 710 3818 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 7516 7156 5892 5889 4683 79728 580 641 10524 7486 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 10635 5890 9156 675 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription 93986 55810 3170 687 9314 9839 6667 5925 8289 7020 11171 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR 1816 1815 1814 1813 1812 134 135 140 729230 7222 7225 5581 5140 5726 57113 1235 5660 5588 10235 10125 7074 259289 259287 5594 259286 5595 259285 6654 259293 259292 259290 259296 259295 5153 5136 10846 5138 50940 5580 2652 5578 4852 207 54429 10645 3549 84254 719 80835 80834 111 112 113 114 1392 115 196883 6608 5573 5575 5576 2778 107 108 5567 109 5568 5727 2550 4893 26960 3265 5294 718 5443 1081 9568 7852 2774 3375 6753 1234 2914 23236 23533 6010 2847 10266 6093 57449 5196 83756 8503 10203 50831 50833 50832 50834 5499 50837 50836 50839 50838 50840 1908 1906 4157 9181 1910 4161 4160 2642 4159 2641 3060 347148 3972 84109 8620 64106 10886 3062 3061 133 2149 2147 7252 5519 11343 5515 27198 5516 8843 5528 338442 84904 3827 26084 2779 5613 6714 7484 5321 2245 6387 7481 5020 4295 7200 115557 5021 7201 431704 56413 8527 8525 8526 5031 116 5032 54361 117 6003 1909 6004 94233 2798 2797 2796 1907 5028 151 5029 84432 89846 1902 6375 1241 2693 3688 26090 57406 10874 29933 222545 10887 1128 7984 5724 257313 1133 5731 3708 5737 3709 5295 64407 2911 387129 5296 2358 846 5290 2915 8111 2864 8477 3710 2922 5996 6655 5997 5998 11214 5999 6846 2925 160851 10161 6863 185 623 624 10451 1609 1608 747 1607 10287 5579 1606 56923 6870 8490 2151 23566 2150 7410 3358 3357 3356 1956 6865 2829 9826 2828 6866 6869 221955 9828 353299 7409 885 22899 886 9287 3363 887 3362 5364 2837 3361 5330 6453 9002 3360 5331 8997 57121 338557 5332 8874 59340 153 3814 154 10911 155 2840 3355 695 2846 594857 83551 301 134864 3269 319100 5583 5577 134860 129521 10672 9038 3354 128674 1132 2867 3352 2865 3274 156 2863 3351 5137 2862 3350 60675 1129 4922 4168 11255 2869 4923 680 27334 84634 139189 4935 5367 23620 9162 3640 10316 51083 4828 90226 4829 2692 26575 338398 2520 1240 7204 9170 56670 84539 2691 10636 2695 4985 4987 3792 1131 10888 5729 2696 27199 10768 5741 5739 80326 2587 5732 5518 4886 5733 5734 4887 4889 122042 1394 1393 2359 26086 29 1269 2357 1268 5744 5745 64857 5746 976 5995 5566 23263 4543 221472 5170 4544 259294 9639 2015 353164 6751 5540 6752 5533 5058 5539 116512 54886 10022 388 79924 389 6755 6754 8811 10268 10267 23365 57105 84152 339403 51384 151306 85397 136 163404 128272 8601 346562 5697 2781 256933 10800 79948 11211 7504 797 27202 2773 611 126006 121512 51289 799 10692 9934 4142 150 8622 152 8862 51052 114131 9718 7433 23370 6344 25791 7432 6288 6343 727 7434 23229 728 8643 5368 1604 5141 796 5143 30817 5144 117579 5139 5151 5030 6001 53829 6002 183 5150 113091 53831 10276 1903 55701 100271715 7473 6915 7472 7475 54848 7477 2768 389337 8326 445328 7476 9459 7479 146 5179 147 7478 148 9890 64748 6019 8698 7480 7482 157 2918 2917 2916 2913 53637 2912 9560 221391 408 11245 55160 8484 11250 11251 1395 23596 57580 186 187 9340 165140 50835 285601 2834 2832 2831 26166 2838 1880 2488 283869 2843 2841 9475 57486 2848 29899 27115 7349 2854 2853 2852 4158 2850 2859 50865 1889 2870 4314 63940 2861 10000 1901 64805 9283 9290 9294 59350 84658 1325 2740 2532 3838 9138 5534 27237 409 7855 7976 2771 8321 8322 7474 2770 8325 8323 1524 8324 208 7471 5582 5530 1894 5532 2780 2535 5956 50649 50650 351 808 1020 5924 7483 6348 6469 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 89780 51764 9630 94235 6000 8787 998 8786 55970 9628 6351 54331 58191 6352 146850 2767 6354 6357 59345 6356 6347 6349 10850 2826 6361 6364 2769 9034 6363 5473 6366 6367 1230 2782 6360 2833 643 2919 10663 2776 6373 6372 6374 10681 6376 6370 1238 2921 6197 6196 57007 2920 6195 1237 3579 1236 3577 3576 1233 56477 1232 4283 6346 10803 51554 10563 3627 7253 122876 26230 170589 3973 2492 5598 50846 814 4986 815 816 4988 817 818 1839 387 5173 3678 6750 551 552 553 554 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress 115209 1965 8894 1968 11331 30968 9812 10730 27102 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS 1588 PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis 221823 5631 5634 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation 5594 5595 5170 27330 6197 6196 6195 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling 5058 5921 5747 10093 10092 4067 10095 2902 2534 8976 10094 60 10097 5879 64283 10096 7525 6093 2904 7074 387 9475 10109 998 6383 6453 71 8997 1072 3984 3985 3265 10552 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 5929 6907 9968 57678 9969 8648 10891 5925 94239 9070 729359 123 23054 60481 10555 22976 25 5166 8202 54145 948 58508 8331 8337 8334 8335 84962 1020 84246 8341 8342 8347 8348 8345 8340 79447 1024 1387 8338 9443 9442 2494 9440 85236 8349 9439 22822 1050 2033 8370 51003 6256 8800 10499 51129 9477 3013 90390 10025 255626 7069 3021 63924 892 3018 3017 2167 3014 57104 79718 11343 2180 8841 474382 9370 10001 23175 8970 128312 55766 79611 8968 4023 23411 29079 2874 5346 7403 5469 6319 133522 9282 653604 84661 9862 84649 11091 9612 3991 9611 8085 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation 50846 6662 2626 5730 2254 23414 1761 7490 6736 2516 268 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins 240 246 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus 5925 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation 10476 10651 506 125988 509 54927 25813 10989 79135 513 514 55735 515 139322 516 8834 440574 517 518 84303 9551 27109 521 9556 522 3313 84833 539 4580 4508 4509 498 10632 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 7316 7099 929 353376 7311 23643 7314 148022 330 6233 8737 7321 7322 11035 3551 7323 329 7334 1147 7335 7189 8517 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs 4686 6634 134353 6636 6635 22916 25888 6637 84967 6628 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA 8815 11168 3159 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry 929 5295 2621 221914 9672 30835 4061 7317 2239 375790 10533 2719 4360 26762 3339 945 3921 9076 7318 51234 3309 22924 5045 1175 10461 160 161 163 11314 2262 6383 10082 440400 6385 9039 91937 6382 2817 5627 7301 79876 558 55236 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell 50846 3549 6868 6469 2262 85455 57758 147111 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B 27338 7316 119504 246184 51434 51433 7311 991 7314 6233 7321 983 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 891 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) 7157 2033 151871 201516 100288687 503835 7004 342900 390245 1387 10413 503627 55211 100033411 79670 284355 23318 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation 10974 688 400569 27332 6907 6517 9968 168544 2033 9969 8648 896 10891 51003 6256 23389 5465 96764 1879 9967 10499 51129 55090 9477 23054 7471 5468 90390 9412 23097 7040 10025 219541 892 8202 2167 80306 4790 948 79718 55588 9441 1959 7124 8841 84246 5970 9370 51586 1051 1019 10001 81857 7480 7026 10498 1024 4023 1387 1052 112950 84498 54797 9443 3952 29079 9442 9440 5346 9314 5469 85441 80205 9282 6721 9439 5105 6604 9862 1050 9612 6837 9611 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism 2875 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 23385 4325 51107 7077 7049 55851 7076 5664 83464 5663 4323 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V 2812 7450 2815 2814 2811 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 5567 5346 5568 857 2173 646486 2172 5499 2171 2167 2170 5500 8228 2820 646480 2169 2168 5501 11343 51099 5566 10226 150379 3991 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) 948 3693 1536 1535 3685 653361 4688 4689 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response 840 842 56616 54205 836 317 331 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade 4836 5145 2779 6295 23173 5158 6010 1259 5148 9626 5475 2342 2339 2792 6011 2782 3000 5588 2979 2978 9397 1258 5578 388531 10988 2986 79823 5957 808 9187 131890 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling 4915 627 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C 138050 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 7516 7156 5892 7517 5889 4683 79728 580 641 10524 7486 51750 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 10635 5890 9156 675 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection 902 6233 920 7316 4869 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 3055 2534 7514 940 5045 8021 3105 10053 162 9978 164 8907 8905 130340 1174 3932 6908 129685 404672 6872 22916 6874 567 6873 23327 2547 27243 55048 23165 4686 128866 89853 10015 6749 9631 7175 6881 6880 5430 6883 55690 5431 6882 5432 8148 5433 6884 7852 6917 11168 79643 1104 51652 51497 11198 6875 6878 83860 8812 6877 51534 2959 2958 6879 375 8815 2957 348995 9883 9525 1022 57122 2963 2962 2961 1234 2960 29082 5436 292 55746 6921 293 5438 6924 137492 5439 6923 27183 91782 23279 25978 79023 51271 7469 138474 10762 8178 92421 6396 8732 7520 129401 8731 51160 6829 3836 4927 3159 7518 155382 6827 9397 93343 9150 7251 5905 79720 2237 1025 5901 5902 51616 5903 3981 9688 23225 25920 54457 51224 7936 55706 3978 23636 9972 11097 23511 8086 53371 8480 79902 51510 904 905 4836 4331 5478 5440 5441 1175 160 161 163 2966 2965 5434 5435 5437 3837 2968 2967 1794 291 2071 9844 2068 926 5879 51606 5062 8065 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System 5928 640 5929 3428 245936 147945 245937 11277 245938 197358 6278 245939 5266 103 5068 4057 6279 6037 613210 116842 613211 245930 728358 245932 245934 671 503841 7422 641517 475 613209 55600 200845 400830 5657 51248 10578 130120 729230 4069 1671 1670 245940 6280 338324 25937 7097 7096 1191 55894 1668 57119 100133267 140683 140881 51297 8784 920 57115 6556 6039 128859 1669 245913 8993 503618 84676 503614 245911 122665 117285 80341 1235 114770 1113 114771 1673 140850 11059 1672 538 417 6406 7004 3934 245927 7003 245928 7005 245929 81623 5079 84659 3347 3346 820 149954 117159 644414 5646 92747 504180 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 114907 11047 10213 5713 5714 7979 7291 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 51176 5687 5688 5689 3958 5700 5701 3726 5702 5704 5705 3977 5580 11340 9261 23404 54512 3312 5393 7534 8741 23016 8021 51010 1981 51013 207 7529 118460 22894 1432 56915 3304 5600 3562 3559 3558 1378 9978 83737 11127 5775 5567 5568 54778 8452 4893 84078 3265 56729 1675 3004 629 718 129685 6872 6874 6873 23327 2547 23165 6749 9631 7175 6881 7525 6880 5430 6883 5431 6882 5432 8148 5433 6884 6917 51497 11198 6875 6878 83860 8812 6877 6879 7323 348995 9883 57122 2963 2962 1234 5436 55746 6921 5438 6924 5439 6923 23279 79023 7469 138474 10762 4088 8178 6396 7520 129401 6829 64750 3836 4092 4927 6827 9150 8463 10273 1025 51616 5903 9688 23225 25920 54457 51224 7936 55706 23636 9972 11097 23511 6097 8086 53371 8480 79902 904 4904 905 1875 2990 3074 57154 411 2720 1437 9246 64135 22926 3551 23586 25820 51191 9451 2537 10964 1147 2289 8517 9636 7318 3309 3429 7706 6456 1175 160 161 2147 163 710 26052 2266 1785 1213 1211 1759 2243 2162 2161 5519 5525 5515 5526 5516 5527 5528 5627 5529 57126 2244 3827 5610 3273 5269 143662 5328 118430 5329 5049 4582 5199 4583 5778 4584 4585 4586 146433 2625 139716 200958 27071 26191 4794 727897 3902 5966 2247 972 5795 6494 23108 10071 94025 55593 140453 4588 4589 2220 283463 1401 8547 10584 394263 2219 3688 5611 51316 3561 4609 3718 29126 5777 5295 3091 5296 5290 5291 3437 4613 3434 3667 3433 5803 4343 192669 23112 27327 26523 23200 27161 192670 57690 595 7040 79895 3845 240 155066 9114 5603 7321 4790 11065 8697 7324 10393 29945 29882 523 1436 996 525 51343 526 51529 527 528 8881 64682 529 5970 27338 246184 127124 3569 23545 51434 51382 51433 6934 6230 6232 533 6231 8575 534 6234 6895 535 6235 50617 6227 6229 8767 6228 57506 9871 4985 7334 9632 7335 245972 245973 10427 9868 9641 8678 5289 3661 9550 23250 3654 3656 2357 8992 90423 976 22863 10396 10312 5170 6382 5894 58505 9296 51311 821 3665 3442 3441 3440 114548 3439 2280 100128731 2268 917 3055 6850 2209 3452 3451 2534 3449 3448 2214 2212 29110 3326 3446 3445 84166 3444 92610 51135 3443 4214 89122 4615 10392 79671 84818 3456 246330 9097 3454 3146 6285 6288 11274 6185 6283 9683 6188 9684 6187 4793 6189 28512 57161 6184 57162 23118 177 121457 28511 2810 80216 3107 54106 3106 3105 746 53831 5648 1603 5781 10053 3482 6191 6193 6192 6194 51125 162 51128 164 84282 81567 7297 2512 6885 3134 8673 3133 2495 8907 8905 5878 3921 7187 7189 84061 130340 6773 6772 80143 1174 3135 7991 340061 1439 1438 10802 201595 10484 10000 3703 2197 23765 84658 3716 8651 8660 140032 1154 3838 2690 51284 5618 1650 2689 2688 1442 10454 8835 5617 6201 2317 30849 1 5534 6203 81844 6202 4973 1476 64127 1489 26007 3664 3669 567 2352 10612 196527 55128 6727 127829 5589 3240 79930 208 5896 5897 51127 85363 3605 1084 6210 4599 112744 5530 284266 4153 5532 23529 89777 9830 51065 6317 7415 5004 6205 55540 6204 56888 6207 5005 6206 8514 6209 5008 6208 326624 6223 79097 6222 84443 11074 6224 5036 257397 26525 387921 11009 222487 7428 9470 6218 7294 6217 50604 84867 808 84868 386653 258010 23087 26578 64806 5912 23071 84418 2896 374395 4600 55223 1116 6809 27189 64170 6813 1143 387263 27179 27177 154881 27178 7320 23608 93978 6950 6836 6478 83716 7325 4692 6477 131405 160364 283807 10379 23218 221687 79654 85480 26272 5553 51088 4215 9616 5547 90678 7726 7317 25840 56658 56954 7319 64581 10533 64109 26234 3093 84174 22888 64114 7332 9870 115362 57826 6468 7336 4261 10425 23650 150726 10694 10346 64718 118424 9961 25801 23295 10576 4281 55336 8638 7327 8635 7326 26190 9867 10321 51646 197131 12 7328 26270 53833 4734 53832 10422 9522 54926 9520 53840 9535 65264 10193 201626 6036 10075 9545 93611 127247 11141 401036 55 25798 79791 55294 55585 25797 6041 57520 51665 6059 282617 89910 7337 282618 51666 282616 55905 54739 23593 26091 79132 63891 80128 63893 3809 142686 170506 57531 26253 142685 55236 3810 51676 3813 8288 142689 9145 223082 84514 10517 22954 3848 8453 91694 79169 10293 2519 9180 9666 81603 51320 84261 80204 22875 54472 57542 54476 51444 11146 10410 135892 201294 80301 55008 6047 10875 6049 26224 3430 10857 23376 23014 114790 5071 124583 54461 1271 29116 1270 57674 388698 143279 25793 388697 338339 84231 4332 11275 8877 10493 9320 117854 55819 64410 23321 90025 6503 7850 222235 84937 4353 140691 353189 11322 51465 10475 54850 5870 23317 140456 6400 55754 140458 11333 90933 2683 170482 140459 90135 163702 10462 25897 5229 25898 25930 9690 146330 55313 24138 140460 3725 6590 140461 5273 140462 255488 199675 114088 5284 54620 401258 7006 23352 868 10394 8916 150372 115290 100049587 6737 3916 7704 3920 55958 80263 8139 50856 390594 51719 57020 127544 5598 55284 84639 27246 1774 84961 2635 8924 3965 2034 122769 53916 8925 9021 53917 1315 64320 1019 388646 9354 81559 3976 55175 133396 10549 84708 56300 7174 27252 200081 51130 2207 642 2206 1027 51132 26095 2205 26046 9903 2204 4591 932 9844 25847 91543 158506 2215 63916 58985 92369 55182 132014 126433 3563 1398 26259 116844 64219 1793 3560 7064 3557 23304 3574 3568 201456 5879 80028 963 144699 965 899 967 5770 84861 968 92912 3575 387 10477 5771 26268 867 3590 55070 3589 90293 3588 5768 84727 92591 5780 26263 5784 26267 8808 8876 53339 8809 285231 3598 89890 3597 6624 4012 9820 8807 26235 8804 26118 5787 79176 5799 26232 8836 55521 23406 84085 10581 4008 4025 9817 10107 51725 566 9039 4033 25831 8887 26249 9725 10562 8065 55658 441864 140739 29949 51619 84329 9040 116379 148581 54918 79876 29952 79754 154664 84541 54941 9730 55801 6286 154214 151636 7130 80176 6282 23194 10068 9604 175 136371 10043 10324 9342 197 51806 83858 22918 51816 84766 3603 4938 3601 3600 11035 3608 1440 4940 5806 1441 1687 8563 9775 7220 7226 5581 4651 4644 196051 84513 4620 4641 7099 929 8772 7186 353376 23643 148022 356 841 8737 7322 997 10892 4067 84433 5588 4792 10235 115727 10125 8915 1823 2889 5906 5317 5594 5595 1399 5604 5493 6654 79792 842 5034 338 991 4842 3635 3636 2799 8878 2322 4507 2444 57761 3552 3553 719 5834 3606 5836 1974 1973 1977 57379 5443 57554 4125 4126 4128 5476 23533 683 8976 210 8503 221 226 230 11069 246 8566 8560 51552 3693 3685 272 117145 9446 11001 7276 11010 3727 2354 2821 7295 6464 5981 10987 5425 10714 3708 3709 3710 10577 2887 3459 3460 9049 8662 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 10480 1964 6804 10768 3313 6844 5864 6048 91445 114876 10956 55276 51009 79923 118788 2323 930 759 940 941 942 1958 50852 90865 5563 9173 9846 5565 837 838 6386 6888 25852 2342 2339 2335 10613 5869 317649 1052 10331 115004 684 51295 5495 4257 4170 138050 1901 23476 5094 54623 1982 50616 2885 353 23601 712 716 721 722 91319 725 26 375 115361 10333 30 5133 23168 163351 47 11160 8672 2923 79139 2956 29760 1639 1660 1654 3839 3840 3841 2939 81030 22872 30011 146850 811 81622 6993 2950 4360 10450 80142 11314 7414 3837 7448 9646 2992 5292 9208 27248 2634 2633 402569 29851 30835 926 4718 114609 945 3554 3570 81793 973 974 2548 3587 5782 10411 3417 51411 7100 4758 6271 56259 10855 80349 2588 6947 1870 4939 1992 5641 6810 8405 23220 5660 6515 2171 410 5211 427 5980 10459 51455 7184 81035 5223 78989 5591 327 3578 3581 5236 51428 25939 5294 5293 2665 10890 7498 6175 1727 5873 11031 58485 9218 374403 22931 93100 8600 4831 28988 2934 6890 6892 6891 64167 4846 51752 51728 27297 4860 661 10623 171568 84265 55703 55718 11128 10622 10621 3306 10438 5728 5394 10200 4311 5743 3101 978 5724 6616 2358 5783 8826 301 3163 3162 5336 7462 51071 14 55824 4048 3080 51422 4179 1361 1380 10877 10878 730 731 27202 732 975 733 713 735 714 81494 715 717 3078 3075 51447 1370 3426 1369 966 727 728 1604 729 5315 178 6935 22914 9402 3937 7305 3822 3824 54209 2717 290 10159 1522 9466 9244 3572 246778 10148 6672 2760 94103 10695 59307 11213 9761 3615 3614 5788 4791 9447 4210 24145 58484 9051 4207 29108 6300 22861 351 10910 10628 5027 834 6502 26469 3082 5908 4780 7975 151888 8764 1938 1915 83439 6657 54920 4602 199990 2175 55120 24137 1062 64837 2189 10019 26153 91442 147700 2188 998 2187 80233 201254 57697 2178 22920 3660 6351 29127 10112 3659 6352 9371 6356 6347 9493 6349 6364 829 6363 5473 6367 1230 3043 81930 2919 3717 84643 830 832 3796 3797 2920 3831 3798 3832 3579 3799 3577 3576 3835 285643 3627 3609 56992 1794 89953 11004 64145 8972 1118 1965 8894 1968 51606 7879 4843 3181 9987 6775 3185 5062 3123 3936 3122 654483 3120 3458 55740 5898 3119 6845 3118 3117 6647 3115 6627 3113 6648 4282 915 27040 5055 916 4001 3595 9398 2533 3594 3593 3127 3592 3126 1072 3125 7408 27250 3702 302 55176 3586 9902 1265 5721 29927 5696 4478 5720 5306 23480 5698 5699 9554 50489 10952 51231 1849 1848 1846 1845 4627 4292 80331 8649 5395 80196 121260 6518 4298 8888 253260 4068 85403 5971 114836 28956 2213 6830 959 4300 6712 3689 4869 59067 3221 3112 3111 7709 3109 5608 3108 27125 55840 1075 93661 5429 5982 5983 23308 2353 8832 3384 3383 55860 1512 1510 11201 1519 8722 55004 3394 835 115650 10120 51164 7412 83547 1026 84516 10437 53632 2475 27301 10671 1386 10673 843 60468 5984 5985 55677 604 9140 9474 79109 4436 5300 3310 3305 55615 634 5562 5564 2176 144455 4361 5571 64223 79733 317 80380 9020 467 8771 9156 4055 4050 5111 1896 8621 4049 8740 7133 8744 4982 8742 7293 332 7292 3604 60401 51330 23495 608 8792 5371 128178 8995 970 10913 939 943 944 9966 8718 7098 9798 54014 11119 11118 696 56244 11120 10385 153579 10384 11240 79908 51561 149233 4502 6093 1832 10970 56667 1828 3929 7341 8554 5930 6095 2316 10788 7329 57630 10787 5478 7157 5175 383 8895 1460 9588 1459 1457 708 4650 4771 6709 25780 4775 5747 6714 5023 5880 79888 6786 80228 8398 84876 5320 4690 122618 4688 55845 4689 8694 2040 23646 2208 8936 5337 5338 64333 50615 57153 147179 51143 2185 6655 9655 10006 10489 23526 6793 9306 10555 8904 10458 10451 55832 5579 7410 5335 29099 10109 8454 8655 23412 6233 7409 1781 3320 1778 203068 695 7535 10552 8987 140735 7316 3071 10133 7431 7532 10383 909 56253 56654 5817 79980 5819 89858 8773 23291 910 911 912 10093 3803 3804 3805 10092 3806 374383 10095 8778 10094 10540 925 10666 10097 3802 285852 3386 10096 3385 4751 23547 29121 4345 10990 6402 8945 933 10871 10870 3811 80184 27180 5518 7454 3812 27181 7456 353514 1525 7311 7314 124599 117157 6500 342510 27 3820 946 3821 7087 983 126014 100132285 340205 10219 146894 57823 10121 5566 10859 11024 120425 11027 11026 11258 135250 131450 9436 9437 10018 5058 4267 596 3695 259197 598 79168 6774 29992 29990 10225 89790 5663 5063 4277 54210 114132 51348 391 11126 11006 644150 339390 100131439 9976 999 100507436 80329 26999 79465 3903 3904 27036 6868 3911 79865 146722 10288 6614 196500 8519 2 51209 1509 1508 5045 1514 1513 10152 1511 6622 3818 1471 1991 23385 1515 51466 71 7077 3015 7076 81619 1520 823 10163 836 1729 54509 960 9341 10810 64386 961 9235 101 140885 102 4312 4313 5645 4314 10326 4317 4318 158747 6595 4297 6597 8411 6599 4064 6598 80231 3932 3663 3684 51082 9450 6908 5931 653361 94239 9070 378708 1780 23054 1536 1535 22976 58480 3728 25 1783 9533 54145 23191 948 58508 1445 8331 23197 8337 8334 3984 8335 51517 7124 4772 4773 4094 5977 10538 6348 8341 8342 8347 8348 8345 3567 3566 3565 8340 4684 3662 79447 1387 5451 60 8338 605 3596 5265 8110 6777 6776 6778 85236 6601 8349 6603 330 10616 6602 142678 6605 6604 7132 1540 7128 329 1050 79577 2932 123169 86 6932 2033 26039 8370 2146 10010 6760 1435 3013 10487 2517 6197 6196 6195 4205 4208 255626 79155 5440 2002 5599 5441 9252 1326 5609 3021 466 6416 5601 7867 5602 5606 3018 3017 3014 5434 5435 5437 2309 2308 10413 8289 23114 474382 6929 57492 5909 8970 815 816 4988 128312 817 818 55766 1493 8726 8968 3687 9274 3683 9275 4680 7403 3676 1088 8193 847 1278 653604 84661 11091 23512 8085 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 9971 1593 11001 10005 8644 3295 8309 8648 6256 80270 5825 1646 1645 10499 1109 570 1582 1581 6718 8647 23600 10998 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint 5687 5688 5689 5700 5701 5702 5704 5705 993 79858 11200 8454 6233 1432 5600 1454 7316 1452 9978 23291 1111 9861 5682 5683 1263 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 2932 5708 5709 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID 3551 1147 8517 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism 64064 38 622 5019 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer 4851 54492 54567 6907 26508 2033 57534 5664 5663 3280 3714 55851 9759 6868 83464 55869 84441 9794 55534 388585 892 8454 6233 22938 23385 51107 79718 10046 8841 7316 51564 10013 10014 8850 79885 9978 1024 1387 23493 9734 23462 28514 3516 83933 7311 182 102 7314 9148 6500 3066 3065 142678 2648 9612 9611 4609 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes 5034 1299 1298 91522 649 80781 1287 84570 50509 8974 10491 7373 256076 23127 136227 10536 7093 81578 7092 871 283208 1305 1303 5351 5352 5033 8985 1308 1302 1307 1301 1306 1300 55214 64175 1310 1286 26577 140766 1285 1284 1282 9508 169044 9509 1281 1280 255631 57642 1297 5479 5118 340267 1278 131873 1277 1296 1295 1294 1293 1292 1291 1290 1289 1288 85301 79709 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters 115584 114134 6526 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins 240 4048 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER 7316 6119 6118 4331 7341 902 10038 2067 9978 404672 1642 8554 2071 1069 5886 5887 2068 6612 7507 7508 142 7329 6613 7334 7336 10401 2966 7311 2965 7314 8451 6233 54778 1643 8450 2073 2072 85015 2968 2967 9557 1022 6117 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway 10454 10133 7186 8737 8717 6885 3551 9099 7185 1147 8517 27005 220213 257397 330 331 10616 56957 23118 7132 7375 55072 81858 10399 1540 9825 7128 329 7124 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity 10369 27092 10368 815 816 817 818 4193 2891 5582 9463 7102 2892 2890 23426 4905 1739 5579 80852 2036 5578 2893 160 1742 9495 4646 59283 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) 83795 89822 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 1738 593 594 1629 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation 6529 10815 6844 6616 5864 6857 80331 6804 2572 6540 6539 22999 18 2571 3312 140679 6538 7915 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes 23760 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport 114757 4151 58157 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function 580 672 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 4056 2948 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate 5111 6119 10714 6118 2237 5424 57804 23649 5422 1763 5557 5558 5425 6117 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF 729238 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling 10454 5687 5688 3708 5689 3709 5700 5534 5701 5702 5704 5705 3710 6850 3551 5580 5530 5532 1147 8517 4791 257397 8454 6233 29108 23118 7321 4790 808 3553 9020 4772 4773 5970 7316 64170 4775 5336 5971 23291 841 7322 6885 997 10892 84433 4792 64581 7334 8915 7335 9861 7189 5682 5683 5684 8945 10768 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 9039 5692 5693 5694 5695 5170 5706 5707 9040 5708 5709 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing 23463 598 9986 81926 377630 58489 51104 10434 2342 51125 2339 808 4893 402 5588 51114 3265 5147 3845 5593 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage 84164 221120 10973 51008 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle 50619 5058 28964 5295 5296 5290 653361 392 3998 10006 396 1536 1535 51566 10451 10424 10787 9815 10298 23092 143098 4983 4810 857 7410 1829 9710 10152 81624 23344 23580 7409 8826 55114 23191 1795 23075 1794 51347 7037 8987 2909 55914 10163 9732 9217 3071 4162 4168 11135 5880 80728 25813 2010 7444 9341 57580 1793 613 7204 9743 57584 26050 7074 7879 3930 8503 55789 5062 55004 81839 4688 143872 55845 4689 998 4580 29 55971 23592 1969 23141 3688 55619 85360 5338 7112 29127 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 9915 4193 4343 192669 23112 27327 2908 26523 146713 27161 1387 192670 341359 6722 57690 3630 8851 10135 405 406 627 266743 2353 7514 2669 5979 10769 30818 5594 5595 5978 440073 1020 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane 2706 2697 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules 6819 10380 25830 54928 27284 445329 8460 8459 84836 6822 27233 6799 6783 391365 50512 6818 6817 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions 5777 7097 6233 7096 3320 7532 7531 6230 6232 6231 6234 64398 6235 6227 6229 8767 6228 57506 9871 7334 9632 7335 64601 79760 10427 9868 9641 8678 5289 3661 81631 3654 3656 91662 22863 5170 2697 51311 3665 27072 3442 3441 3440 23367 114548 3439 10971 3452 3451 3449 3448 29110 3326 3446 3445 3444 54960 3443 89122 10392 84818 3456 3454 55823 857 7534 6607 8487 8021 6188 6187 6189 207 23118 7529 2810 3107 3106 3105 5648 5781 6632 6191 6193 6192 7284 6194 26276 51128 65082 84282 6628 7297 23339 6885 3134 3133 9908 6634 6633 6636 6635 10146 3921 6637 7187 7189 6773 6772 80143 79833 3135 92359 340061 11218 10802 10484 10000 50628 2197 7082 23765 3716 140032 3838 51284 10454 6441 6201 30849 6203 6202 7533 64127 26007 567 23165 208 11311 7405 3605 9631 6210 7175 112744 4153 25929 51065 6205 6204 6207 6206 6209 6208 6223 6222 7555 6224 257397 10207 6218 6217 57617 348995 9883 57122 55746 23279 79023 10762 6396 1387 129401 4927 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 64135 3551 23586 1147 8517 9636 7706 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 2617 23438 57176 25973 55157 3735 80222 10667 79731 79587 51067 55699 5859 124454 23395 57038 10352 92935 27068 54938 57505 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 5395 4292 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 4128 4129 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 10585 1605 29954 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation 4706 2230 1737 1743 1629 11019 2653 387787 27247 51601 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor 151 150 152 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis 57551 30849 8678 5289 79109 253260 4793 64223 54463 8737 57521 2475 1616 4792 22863 55615 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis 2812 7450 11093 2815 2814 2153 2811 8460 2147 2266 8459 2243 196527 2677 2160 2159 2158 2157 5624 5627 2244 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 5928 91750 1874 286826 132660 4605 55957 890 1869 3065 7027 983 7029 5933 5934 1875 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 3354 3352 3363 3362 3351 3361 3350 3360 3358 3357 3356 3355 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 54492 4851 7316 54567 28514 57534 7311 182 102 7314 9148 142678 6233 3714 6868 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism 378884 3417 113612 2584 3712 5373 79868 29929 1545 4758 7957 2592 11081 2588 6948 6233 1583 9060 2132 2131 549 340665 7316 1594 1593 1591 1589 1588 1586 79644 1585 1584 162417 57407 6487 126410 100 126792 7311 7314 3795 7057 3955 593 6383 594 10082 6385 6382 5507 4060 4851 10568 4669 64087 5096 25974 686 221914 5091 9672 56922 4969 3141 31 2239 5095 9510 56603 26873 9507 2799 1634 435 5826 2262 2331 2328 1836 5549 11253 445 170690 2817 170692 7841 10020 191 55788 6888 5236 81693 8029 63827 7172 2719 176 3339 113189 85365 56999 11096 79947 11095 2729 4552 112812 51293 8908 653509 6440 729238 6439 1439 4158 11041 4548 1438 9215 2730 79087 55624 138050 1605 10195 11285 6448 4247 3251 6441 199857 4594 5443 23169 54658 79053 375790 353 4958 4128 4143 5476 54344 38 27249 21 10295 1738 9526 51181 116150 2673 4166 56052 56667 229 326625 166785 2937 1462 79796 2990 11093 26275 3373 95 3074 22845 2632 3073 3425 120227 411 2720 3423 92579 633 1463 10675 4351 5053 1629 54657 2582 130589 3938 6476 1892 1373 5009 383 9420 2683 4853 4854 4860 4855 91869 2678 2998 2997 2992 2694 145173 57188 2591 143662 10417 152926 118430 10418 1798 170689 171019 2232 54437 26229 9037 2230 4582 5199 4583 4584 7058 4585 4586 10166 200958 9469 157869 29954 727897 29071 140766 2538 80070 10585 9508 9509 10071 2548 94025 339366 221981 140453 79875 2542 81794 4588 55901 440138 4589 22934 81792 283463 9719 56913 394263 11173 8813 11174 8818 80731 54507 92949 6916 170691 22856 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS 6464 7867 4914 5898 5899 25759 5603 6300 5900 4803 1432 4893 6654 9261 5600 3265 53358 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids 389396 116285 219970 348158 92292 123876 341392 10249 54988 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins 23556 257194 266727 27076 420 1368 80055 1048 54742 284348 6975 50863 123904 154064 2813 4061 349667 94005 5067 54344 8733 146183 116372 2822 248 84720 54872 53942 128869 152330 284098 683 338328 353091 2350 51604 5329 4062 5277 137797 2215 5279 390243 93183 8581 84628 10942 55650 171169 80235 51299 249 7007 54965 84992 10026 4978 360226 147719 5283 9487 8875 9488 8876 135228 23627 161357 130576 8434 1043 1087 58530 146760 251 5281 22854 80740 8813 503542 646627 8818 51227 10232 419 349633 8000 4241 4045 7512 80328 7070 83639 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS 4128 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 6529 79751 246213 340024 6532 54716 6582 6580 57084 9152 57030 6531 6536 6530 6534 55117 11254 6540 83733 140679 6538 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors 134 135 140 5031 5032 27334 136 5030 5028 53829 64805 5029 10161 2840 2846 9934 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 8772 7706 84282 841 8737 64135 843 3551 57506 23586 1147 8517 89122 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation 4094 10013 2737 6714 5925 121340 23314 25937 1277 3280 367 5594 5595 10413 23493 221044 7525 25925 632 865 25 8841 23462 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane 6128 6129 10952 6201 23478 6142 6203 6202 6141 6144 6143 6146 6147 6727 6139 6138 6152 6155 6154 9789 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 6176 6171 6170 6173 6181 6230 6232 6231 6234 6734 6745 6235 6227 6229 6228 7311 60559 27230 6746 6748 6747 6731 6730 6729 6726 6728 23471 11224 25873 6188 140801 6187 6189 28972 58477 9349 6191 6193 6192 6194 90701 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 55176 6136 51121 140032 29927 4736 23480 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection 5928 317772 6907 51143 85235 5931 3190 11267 51028 27243 84313 55048 1780 23165 128866 89853 9631 7175 221613 1783 92815 79643 8969 51652 1956 440689 8655 1781 4790 8331 1778 348995 8337 9883 8334 8335 57122 5119 29082 140735 55746 8341 137492 8342 8347 8348 27183 8345 91782 23279 25978 79023 51271 8340 10762 92421 6396 129401 8338 51160 4927 155382 93343 7251 79720 85236 8349 10155 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 8370 2146 1616 3013 255626 2002 8021 3018 3017 79718 8841 8970 128312 10951 5371 8726 8968 1052 2874 653604 3688 9612 9611 23512 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres 8076 4052 7043 4053 650 4054 7042 10516 2202 30008 8200 8425 7040 652 3693 3694 3685 3690 655 27302 3696 4237 4238 4239 7448 2199 8516 2192 3688 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation 9 10 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 7316 80196 4194 639 1029 1017 79109 253260 890 6446 8900 4193 208 1616 900 9099 55615 7157 5518 11200 7311 7314 64223 7874 472 207 6233 983 117584 2475 5519 10000 5515 5170 5516 5527 51230 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism 84618 4907 30833 7498 56985 55270 131870 10591 4860 11164 93034 22978 3704 9615 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 3718 80824 5295 896 5296 10818 5290 5291 3667 4343 192669 23112 27327 26523 27161 192670 57690 1739 3845 1849 1848 1852 9986 1846 1850 81926 5156 1950 377630 58489 51104 2064 1956 8036 2251 25759 6233 5900 8826 8649 8997 7316 10435 3569 8550 28956 5500 4296 6712 5588 115727 10125 9861 5682 5683 7039 5684 5685 5686 5717 5518 5718 5719 7311 7314 11047 10213 5713 5714 7979 983 673 5906 5690 5594 5691 5595 5692 5604 5501 5774 5605 5693 6654 5694 5566 2254 5695 8074 5706 2249 5707 2246 5894 10817 5708 8823 5709 8817 26281 5058 23463 5687 598 5688 5689 5700 5701 5702 5063 5704 5705 3337 2534 5155 3315 8556 8555 2323 8682 148170 5159 10642 7514 221002 2118 5863 9693 989 2322 54756 84292 57139 5596 2264 5597 7529 9965 152831 51114 255324 3562 10048 3559 3558 5781 10434 2342 51125 9978 2339 2335 7297 408 10256 5593 5567 5568 4140 88 1439 1438 5037 1742 8452 4893 9462 4763 1741 64926 3716 84078 8660 1740 8831 3265 399473 10156 161742 200734 22821 153090 8437 5921 5922 4747 409 2906 2902 5896 5897 57554 23179 283455 5923 8202 6300 808 11221 1445 5924 5147 3082 5908 4233 374 3567 9048 369 64096 4902 4684 2675 5623 2248 2255 2252 27006 2904 998 402 3815 2676 6708 7450 6710 22866 22808 5786 1437 3717 53358 57731 2266 7414 3690 3725 2243 2309 5519 2308 51332 5525 8315 5515 6709 25780 5526 5516 5527 5536 5528 5529 9542 2244 3084 5245 6711 815 5747 816 6714 2069 817 7094 818 685 3563 152559 10718 3560 5778 1844 1843 3568 1839 1847 5879 10602 2668 145957 2247 3570 3674 5979 5062 7010 6464 284 54518 2674 3561 4609 8844 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 941 5518 942 207 1493 4067 5519 10000 208 2534 5525 5515 5526 5516 7525 5527 5528 5529 5781 3932 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH 7296 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation 23649 5422 26277 25913 5557 65057 5558 7013 7014 54386 79991 80169 100134934 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation 6483 6482 6484 6487 10678 6480 256435 27090 7057 56667 11093 2589 10610 9510 9507 22915 55568 79812 11227 84002 11226 374378 51809 9334 9245 9331 168391 63917 51146 51301 50614 148789 23275 170690 8693 129080 442117 374907 64409 93010 146664 170692 84752 140687 84750 84197 114805 2650 192134 117248 145173 146712 57188 26290 2591 170384 143662 57452 10417 79623 118430 84892 10418 2590 10164 170689 171019 54437 9037 4582 5199 4583 4584 79369 7058 4585 4586 200958 157869 29954 727897 56999 10331 29071 140766 11096 80070 10585 11095 9508 9509 10071 94025 339366 221981 2218 140453 79875 10329 10559 81794 9486 4588 55901 79147 11041 4589 81792 9215 283463 113829 55624 9719 729920 56913 394263 1605 120071 11173 11174 80731 54507 92949 170691 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 6657 79923 5460 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS 6439 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 3768 59345 3773 2793 2792 2791 2790 3758 2782 3764 2788 3767 2787 2786 2785 2784 2783 10681 51764 10060 3770 9568 3760 3761 2550 94235 3759 3772 55970 6833 3762 3763 3765 54331 3766 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome 7316 5687 5688 5689 5700 5701 51684 5702 5704 9978 5705 83737 2735 9861 5682 5683 5567 5684 8945 5685 5568 5686 5717 5718 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5566 5695 5706 5707 8650 5708 5709 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 6201 6203 6202 6210 51065 6205 6204 6207 6206 6209 6208 6223 6222 6188 6224 6187 6189 1981 6233 6218 6217 8662 8663 8661 8666 8667 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6191 6193 6192 6194 6230 6232 6231 6234 1975 6235 1974 1973 6227 1983 6229 1977 6228 1965 8894 1968 3921 2197 140032 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA 9337 1975 1974 246175 1973 1977 9924 255967 57472 9125 79670 9775 23318 10605 29883 85456 5073 25904 4850 1981 23019 4848 4849 26986 55571 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k 56052 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism 10057 2990 3161 23553 3373 8372 3074 3038 55576 3073 3037 3036 6677 6548 960 10894 26503 8692 11261 57214 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation 10714 5929 51143 56259 80349 4627 8655 4292 6233 1870 4790 1781 1778 920 5395 5970 7316 140735 4298 8888 4068 85403 5971 114836 2213 6830 959 4300 6712 3689 59067 5079 3221 3112 10540 3111 7709 3109 3108 27125 55840 1075 93661 5982 5429 5983 23308 8832 3384 3383 55860 1512 1510 11201 1519 8722 3394 7311 115650 7314 10120 51164 7412 83547 84516 10437 27301 10671 10673 5984 60468 5985 55677 604 10121 11258 6774 4436 114876 1380 11340 23404 5980 54512 10459 51455 1509 144455 1508 5393 23016 1514 1513 51010 51013 118460 1515 22894 56915 79733 1520 9156 1378 5111 11127 57379 6595 6597 6599 6598 6908 718 129685 54623 6872 6874 6873 9070 1780 23054 6749 22976 6881 6880 5430 6883 5431 6882 5432 8148 1783 5433 6884 6917 4791 51497 11198 6875 6878 83860 4207 8812 6877 58508 6879 2963 2962 4094 5436 5476 10538 5977 6921 5438 23168 6924 5439 6923 7975 3565 7469 138474 3662 79447 8178 1387 60 605 6829 8110 6827 6778 4602 9150 24137 1025 6601 1062 2956 64837 6603 1639 51616 26153 6602 6605 147700 6604 25920 54457 51224 7936 22920 1050 79577 29127 123169 904 1875 10112 905 86 9371 9493 26039 829 6760 81930 84643 830 832 3796 3797 3831 3798 3832 3799 5440 5441 3835 285643 5434 5435 5437 56992 9646 89953 8289 11004 6929 57492 10438 29851 5394 10200 9274 3683 9275 3727 2354 7879 973 7403 974 3676 3123 3122 3120 3119 3118 8193 3117 3115 5981 3113 84661 3127 3126 3125 11091 3688 5425 8085 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 1384 10005 3295 8309 55289 23600 8310 54677 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions 4897 8828 286 1741 6900 1742 1739 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 3718 80824 5295 5296 10818 5290 5291 3667 1739 3845 1849 1848 1852 9986 1846 1850 81926 5156 1950 377630 58489 51104 2064 1956 8036 2251 25759 6233 5900 8826 8649 7316 28956 5500 4296 6712 5588 115727 10125 9861 5682 5683 7039 5684 5685 5686 5717 5518 5718 5719 7311 7314 11047 10213 5713 5714 7979 673 5906 5690 5594 5691 5595 5692 5604 5501 5774 5605 5693 6654 5694 2254 5695 8074 5706 2249 5707 2246 5894 10817 5708 8823 5709 8817 26281 23463 5687 598 5688 5689 5700 5701 5702 5704 5705 2534 5155 2323 8682 5159 221002 5863 9693 2322 54756 84292 57139 2264 7529 9965 152831 51114 255324 3562 10048 3559 3558 10434 2342 51125 9978 2339 2335 408 10256 5593 4140 88 1439 1438 5037 1742 8452 4893 9462 4763 1741 64926 3716 84078 8660 1740 8831 3265 399473 10156 161742 200734 22821 153090 8437 5921 5922 4747 409 2906 2902 57554 23179 283455 5923 6300 808 11221 1445 5924 5147 3082 5908 4233 374 3567 9048 369 64096 4902 4684 2675 5623 2248 2255 2252 27006 2904 402 3815 2676 6708 7450 6710 22866 22808 5786 1437 3717 53358 57731 2266 7414 3690 2243 5519 51332 5525 8315 5515 6709 25780 5526 5516 5527 5536 5528 5529 9542 2244 3084 5245 6711 815 5747 816 6714 2069 817 7094 818 685 3563 152559 10718 3560 5778 1844 1843 3568 1839 1847 2668 145957 2247 3674 5979 7010 6464 284 54518 2674 3561 8844 METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host 3043 3040 NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance 1312 6580 220074 217 6531 4128 590 43 6532 6582 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization 5861 64689 9133 8615 983 5347 81876 5594 5862 2801 26003 8548 891 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling 10454 5777 10068 5783 64127 59307 11213 240 4791 257397 8454 26525 6233 351 4790 84867 834 26469 5970 7316 7186 27179 27177 27178 3565 23291 841 4088 4215 8767 4792 5608 3596 7334 7335 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 3654 5714 7979 11141 3656 5690 5691 5692 5604 5693 5694 5695 5706 5707 5708 5709 79792 5687 5688 5689 6774 5700 5701 5702 5704 54472 5705 3551 29110 84166 92610 1147 51135 7850 8517 4615 10392 79155 79671 7157 246330 9097 5599 3146 6285 1326 8878 6288 11274 6416 6283 9683 1511 9684 4793 25930 28512 57161 57162 177 23118 90865 121457 28511 80216 9173 3552 3553 3606 84639 5781 56300 9978 26095 6885 5778 3557 5775 7189 5771 3554 5780 5784 8808 8809 8807 5782 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors 7157 1029 7341 7022 7021 7158 8554 4286 4193 6612 9112 51588 3090 7329 6613 668 10401 6670 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia 383 DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC 51293 6948 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase 23421 51143 55732 401541 64105 378708 1780 79172 27436 1783 83540 80152 9662 8655 3619 7840 11064 64946 1781 3320 22994 22995 7283 1778 348995 10733 80321 203068 55722 57122 1454 699 1453 55125 5577 9814 140735 9738 55746 11190 25936 9793 7532 7531 10383 10382 23332 6232 23279 115106 79980 79441 95681 79023 54908 1069 5347 22919 54801 10142 6396 7846 9702 10540 5108 11116 4751 5048 55142 22897 891 54930 151246 9735 5116 79959 5905 80184 5518 93323 7277 1062 9133 5903 23354 22981 8481 80254 983 121441 220134 55755 57082 54820 10806 5501 10121 5566 55835 6249 55559 8636 11258 79902 84131 4957 9212 25909 9183 54821 9184 991 23122 4085 701 81930 84643 55920 3796 57405 7514 1460 10403 1459 80776 1457 11243 23047 5519 113130 23244 5525 23063 5515 91754 5526 140609 5516 10783 5527 11004 5528 5529 91687 57551 79682 11130 332 2491 55839 8379 55143 9126 64151 10592 10735 9918 23397 10051 55166 10726 79019 10274 8243 1063 1060 151648 5885 1058 79003 4926 55055 114791 85378 10426 27175 81565 653784 29922 27229 440145 10844 80097 147841 348235 NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing 4803 5046 5045 5125 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis 1462 92370 9917 63827 633 221914 9672 1463 10675 26229 27087 2239 375790 2719 3339 80146 135152 126792 1634 2262 64131 6383 64132 10082 6385 11285 6382 2817 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 10454 3708 3709 5534 3710 5530 5532 4791 257397 8454 6233 29108 7321 4790 808 4772 5970 4773 7316 64170 5336 93978 5971 23291 841 7322 997 10892 4067 84433 1387 64581 4792 7334 8915 3385 7335 9861 5682 5683 5684 3384 8945 10768 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 56667 7979 5690 5691 5692 5693 5694 5566 5695 5170 5706 5707 5894 5708 5709 26253 5058 5687 5688 5689 2033 5700 5701 5702 5063 5704 5705 6850 2534 3551 5580 338339 1147 8517 9252 170482 10462 23118 50856 3553 9020 4775 2207 143662 118430 6885 30835 4582 4583 4584 4585 4586 200958 727897 7189 5567 5568 10071 94025 5062 140453 4588 4589 283463 394263 9039 4893 3265 9040 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 6176 8662 8663 6171 8661 6170 8666 6173 8667 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6181 6230 6232 6231 6234 6235 6227 6229 6228 7311 11224 25873 6188 140801 6187 6189 1981 9349 6191 6193 6192 6194 1975 1974 1973 1983 1977 1965 8894 1968 3921 9669 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 6160 6189 6161 6233 6218 6217 6175 6176 6171 6170 6173 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 6235 6227 6229 6228 3921 53918 6122 6124 6123 116832 6125 7311 6130 6133 6132 6135 6059 2197 6134 6137 6136 140032 51121 4736 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi 4851 5870 6400 5045 2683 4853 5986 4854 4855 3955 487 10959 488 489 4242 6484 10402 6487 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling 3977 861 1997 865 3562 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes 55788 1504 440387 2694 5646 81693 6947 5826 8029 5644 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH 2678 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 3032 3030 3033 34 1892 51102 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors 2677 2155 2159 2621 2158 2147 8858 5624 632 5627 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts 9971 6555 6554 8648 6256 2172 80765 10499 10599 8714 28234 6579 570 200931 8647 10998 123264 213 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR 5295 10818 5290 22916 4686 10253 8569 5430 5431 5432 5440 5433 5441 80004 5335 3178 54845 4670 3187 2264 2251 23543 7073 6233 7072 5434 5725 5435 9965 5437 10755 152831 7049 5515 5516 2963 2962 5781 7316 3730 5436 5438 2549 5439 2591 9982 83888 2248 2255 2252 27006 143282 53834 867 2247 3185 5518 7311 7314 23768 23769 23767 673 5594 5595 4893 6654 2254 8074 2249 3265 2246 10817 8823 8817 161742 26281 200734 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex 5518 1452 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases 54890 121642 84164 221120 10973 51008 79068 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors 1896 4049 8740 7133 8744 4982 7293 7292 3604 60401 8764 356 8600 23495 608 128178 8995 970 10913 939 943 944 9966 8718 8741 7132 10673 8784 8771 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 9855 8829 7094 55558 91584 5361 23396 2534 10371 2242 27289 5879 6237 5362 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) 340024 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) 10999 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions 9530 2260 11160 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB 808 10645 814 84254 815 816 817 818 3838 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition 5928 29935 10926 55388 894 896 902 7153 5925 23649 5422 993 54107 208 5557 5558 595 25 4149 8454 6233 1870 6502 5933 5934 1022 1719 6117 7316 6119 6118 91750 286826 1032 132660 1031 1029 55957 8317 4067 9861 5682 891 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 5518 4176 5718 5719 8318 7311 7314 4171 11047 6500 10213 5713 5714 7979 1026 983 91768 5690 5691 5692 990 5693 51053 5694 5000 6241 5695 7083 5001 7465 23595 5706 23594 5707 81620 4998 5708 1876 4999 5709 1875 5687 5688 5520 4331 5689 5700 898 5701 5702 5704 26271 5705 9134 890 8900 3717 1874 4605 1869 207 7027 1871 5519 5515 7029 5516 5111 1019 1017 1027 1028 5753 1021 1859 28227 1163 7298 1030 3065 10000 56655 5426 5427 4609 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 7450 5908 5245 22866 815 816 6714 817 7094 409 818 2335 369 4296 408 3717 10256 3845 3674 283455 4140 2266 7414 3690 5037 2243 54518 7529 673 8826 808 5906 5594 5595 1445 4893 5604 5605 8315 3265 5894 2244 8844 FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct 2247 3214 3975 5979 5076 2122 1499 255743 2018 10406 3203 130497 3400 2625 51316 7849 652 57526 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR 1738 5160 1737 5161 8050 5162 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing 5436 5438 5439 22916 4686 5430 5431 5432 5440 5433 5441 3185 80004 3178 54845 4670 3187 23543 7073 7072 5434 5725 5435 5437 2963 2962 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses 23168 54623 64135 57506 3326 4153 23601 6773 8241 115004 55763 7706 9641 80349 712 716 721 340061 722 725 1654 1191 3320 23352 7448 9646 335 79577 123169 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) 6128 6129 22794 6201 6142 6203 6202 6141 6144 22916 6143 6146 9939 6147 6139 4686 6138 6152 6155 65109 6154 6210 6157 6156 9775 6159 6158 51065 200916 6205 10921 6164 6204 6166 9045 6207 6165 6206 55110 6209 23708 6168 6208 4116 6223 26019 6167 6222 6169 6224 23521 2107 6160 6161 65110 6233 6218 6217 6175 2935 6176 6171 6170 6173 6181 6230 6232 6231 6234 6235 6227 6229 6228 5518 7311 5520 11224 55802 25873 6188 140801 6187 6189 1981 5515 26986 9349 6191 6193 6192 6194 3921 6122 23049 6124 6123 23293 116832 6125 9887 55181 23381 55629 5976 56006 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors 3417 57107 51805 10229 48 2644 2643 56910 6697 51004 51117 5593 5805 84842 84274 4846 57017 207 27235 808 3320 23590 56997 1719 79934 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling 2247 7316 5518 10818 7311 7314 6233 673 5594 5595 5515 2254 8074 10253 5516 2249 8569 2246 8823 5781 8817 867 26281 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping 5436 4331 5438 5439 902 404672 22916 2071 2068 4686 8732 8731 6829 5430 5431 5432 5440 5433 5441 2966 2965 5434 5435 5437 83640 2968 2967 1022 2963 2962 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 831 7531 356 3725 6648 351 993 4001 994 995 84290 5052 2309 2801 1020 823 8851 824 7001 826 10018 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane 146850 27124 5294 5295 59339 59338 5296 5783 5290 5291 81846 5293 23396 660 3631 3635 3636 8821 51552 55361 4952 5305 65977 79837 55613 375 66036 64419 55300 23533 84725 5728 8871 8776 57664 4534 80230 8396 5867 51763 8867 8394 5868 8395 22874 8503 54477 8897 8898 5286 5287 5288 9107 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n 91869 DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism 55788 4552 51293 4594 27249 6948 64087 81693 5826 5096 8029 25974 686 4548 5091 56922 3141 31 5095 326625 166785 2694 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 23165 6139 197259 6138 6152 6155 9631 6154 6210 7175 6157 6156 5430 6159 7040 6158 51065 200916 5431 6205 5432 6164 6204 6166 9045 6207 5433 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 3320 6176 6171 6170 348995 6173 9883 57122 2963 2962 5436 55746 5438 293 6181 5439 6230 6232 23279 6231 6234 79023 6235 10762 6227 6229 6396 6228 142 129401 3836 4927 5901 7311 5903 9688 23225 3839 55706 3840 3841 23636 9972 11097 23511 8086 53371 8480 10898 79902 821 811 9636 7514 5440 11224 5441 25873 8021 6188 140801 6187 6189 1213 1211 5434 5435 5437 3837 3304 9349 6191 6193 6192 5610 6194 2633 402569 8106 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 5611 51121 140032 3843 3838 2926 4736 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE 81622 7098 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 6907 4862 2033 8648 10891 6256 96764 5465 6095 10499 10498 23054 1387 8204 23411 23373 406 4208 5469 85441 80205 6604 9575 1386 79718 9572 4209 64784 6097 200186 10743 6096 9611 8841 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints 10926 55388 7533 165918 7158 993 54145 472 6233 144715 5810 5932 11073 6117 7316 6119 6118 8341 8342 7532 8347 7531 8348 8345 8317 8340 1111 9656 7334 10524 7336 7486 9861 5982 5682 891 5983 5683 5684 84515 4172 5685 4173 5686 4174 84126 4175 5717 4176 85236 5718 5719 9133 8318 8349 7311 7314 4171 11047 10213 5713 5714 7979 983 5690 5691 5692 5984 990 5985 5693 5694 5000 5695 5001 5883 7465 8290 5884 23595 5706 116028 23594 5707 4998 5708 4999 5709 5687 7156 5688 5689 4683 5700 5701 8370 5702 5704 5705 890 8900 3364 10971 995 51588 641 63967 255626 7157 7534 11200 10111 4361 3018 3017 3014 1763 7529 545 2810 80010 672 29086 9025 9156 8924 51720 84142 9577 79184 8970 1017 128312 51512 83695 580 83990 7468 9088 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway 8808 27179 27177 56300 26525 84639 M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase 23421 51143 55732 64105 5925 2801 5579 9662 8655 7840 6233 7321 11064 1781 25906 3320 11065 22994 22995 8697 7324 7283 10393 1778 29945 10733 80321 29882 203068 55722 996 1454 699 1453 51529 55125 8881 64682 5577 9814 7316 27338 140735 9738 119504 11190 246184 25936 9793 7532 51434 7531 51433 10383 10382 23332 6232 115106 79980 79441 95681 54908 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 9861 22897 5682 891 54930 5683 151246 5684 9735 5685 5116 5686 79959 80184 5717 5518 93323 5718 7277 5719 9133 7311 7314 11047 23354 10213 5713 22981 5714 8481 7979 80254 983 121441 220134 5690 55755 5594 57082 54820 5691 5692 10806 5501 23141 5693 10121 5694 5566 55835 5695 6249 55559 5706 8636 5707 11258 84131 5708 4957 5709 9212 5687 5688 5689 5700 5701 54821 9184 5702 5704 23122 991 5705 26271 4085 701 55920 7514 5578 8021 3842 11243 91754 387893 140609 10783 6418 11130 332 55839 8379 5862 26003 8548 64151 10592 9918 23397 10051 55166 79019 260334 6683 9798 200014 347688 10776 79003 79648 4926 23383 114791 55055 22933 85378 10426 84930 27175 2029 653784 29781 81565 29922 55844 27229 54892 23310 440145 10844 25836 80097 147841 401541 94239 378708 27243 1780 23165 79172 128866 9631 7175 27436 1783 83540 79643 80152 1104 51652 54145 3619 64946 81876 8815 8331 348995 8337 9883 8334 8335 57122 29082 55746 8341 5861 8342 8347 113457 8348 27183 8345 91782 23279 25978 7280 79023 8340 10762 92421 6396 129401 8338 4927 10376 80086 3930 5905 64689 85236 8349 1062 5901 51807 5903 8615 9688 23225 10381 23592 112714 55706 23636 9972 84790 11097 23511 8290 8086 53371 8480 79902 84617 10112 5520 9493 25909 7341 9183 347733 8370 7278 79861 81027 81930 9232 7329 3013 84643 3796 57405 255626 3021 1460 10403 3018 1459 3017 80776 1457 3014 3837 23047 5519 113130 9700 23244 5525 5515 23063 5526 5516 5527 7443 11004 5528 255919 221496 5529 23399 474382 91687 57551 79682 23175 8970 128312 2010 2491 55766 55143 9126 8968 10735 10726 10274 64900 8243 1063 1060 151648 5885 1058 9663 653604 4001 348235 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels 131096 3784 3756 3736 23416 9312 90134 93107 23415 9196 169522 3748 3749 170850 27012 27133 3742 3787 3743 3788 3744 3746 3790 8514 26251 3741 9132 3745 3747 3757 3750 3751 7881 3752 3737 56479 3738 3739 3785 81033 3786 3754 3755 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination 7156 4683 63979 8370 55732 94239 3013 641 255626 3021 56979 10111 4361 3018 4292 3017 54145 472 3014 8331 8337 8334 672 5932 8335 11144 23626 474382 6117 6119 6118 1019 5889 8341 29893 8342 8970 8347 27030 1017 8348 84057 128312 8345 4438 4439 8340 55766 8968 8338 85236 8349 653604 5888 8290 675 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose 29880 256281 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex 86 26039 6601 6603 6602 6604 6760 60 23506 6595 65980 9274 605 29998 9275 6597 6599 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function 673 5501 8036 22808 5894 369 5500 7529 MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins 7514 5045 23478 1460 5499 1459 60559 1457 5500 28972 3837 5501 9789 90701 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption 6514 6248 6518 6523 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 6616 9900 9899 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events 28964 8825 4900 4747 9647 8573 2891 51422 2906 2905 2902 22843 320 27330 2892 6197 116443 2890 6196 5562 6195 5564 1739 57554 116444 2893 5571 5923 808 64130 5563 10645 5565 84254 8536 57576 5924 5577 3084 114 814 815 5613 6714 816 817 818 5573 5575 5879 5576 2904 2903 107 5567 5568 88 55327 1742 53632 5594 5595 4893 5566 1741 5170 1740 3838 26960 3265 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5908 6888 6950 829 5478 759 3181 9049 9987 6775 3185 5062 3936 654483 3458 5898 3313 6647 6627 6648 998 4282 6175 4507 5055 4001 375 1072 27250 2939 302 3586 1265 9446 5721 4478 5306 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression 3105 1174 8907 162 8905 164 567 55690 130340 10053 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants 5518 1452 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells 3781 3778 3779 55584 57053 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport 389203 284184 1537 10131 80775 84300 2110 9997 119559 2108 54902 93058 55863 2109 84233 79064 54539 91942 25880 84701 90639 440567 90624 126328 54205 25994 137682 51204 8402 125965 55245 7385 6341 7384 51079 3313 7386 7388 7381 100303755 55744 6834 150274 80219 79133 3954 83733 5018 80224 100996939 116228 4190 4191 341947 4694 27089 4695 29796 1327 4696 29090 493753 6389 51241 84987 1329 1340 6391 10063 55572 1337 6390 1339 6392 1351 1350 4697 1349 3052 55101 1347 29078 1346 1345 192286 9167 374291 4705 1355 79751 4706 1353 51103 4707 2806 4519 2805 4708 790955 4512 4513 4709 55471 4514 4700 4701 4702 4704 4716 4717 4540 4718 10975 285521 4719 4541 10165 4710 4711 28976 4712 440957 4713 57226 8604 4535 4714 4536 57128 90871 4715 4537 4538 4728 9377 4729 51295 4720 152100 617 4722 4723 100131801 4724 4725 4726 25915 2395 613227 4731 28958 728568 55967 55969 51300 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 197342 7516 10714 84464 7517 51426 63979 23514 80198 5424 55732 57804 79008 165918 2067 79728 7158 5893 54107 54962 151987 5531 25 8914 54145 472 6233 144715 5810 5932 11073 6117 7316 6119 6118 8341 8342 8347 8348 8345 8340 1111 9656 7334 10524 7336 7486 5429 5982 5983 84126 85236 8349 7311 7314 7979 5984 3978 5985 5883 8290 5884 116028 7156 5892 4683 8370 890 8900 3364 6047 51588 641 7329 6613 51750 63967 255626 10111 4361 3018 3017 3014 1763 545 51548 80010 672 29086 9025 5890 9156 8924 51720 5111 84142 9577 79184 5889 8970 1017 128312 83695 580 83990 7468 5981 2072 56655 5888 5425 5426 348654 5427 10635 146956 675 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 5928 5929 2033 8370 5931 2146 6256 94239 9070 5915 23054 5916 57472 3013 22976 9125 5914 5430 4211 5431 3200 255626 9063 5432 9935 5440 5433 3211 3201 5441 63925 3021 3213 3212 5316 3233 3232 3198 3018 8202 3231 3017 54145 3725 5080 3014 5434 3199 5435 5437 58508 8331 8337 8334 8335 84962 1959 8841 474382 5436 5438 8341 8342 8970 8347 5439 8348 128312 8345 8340 7528 55766 79447 8726 8968 1387 3221 7703 8338 3214 7403 10664 85236 8349 653604 84661 11091 5087 9611 23512 8085 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling 238 5764 4192 5803 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions 9444 7450 22866 22906 9715 409 1185 3717 283455 54845 2266 7414 3690 2243 7529 8826 808 8087 1445 9061 57085 80853 2244 10827 5908 23164 815 8546 6714 816 55109 7094 817 818 2335 369 27044 408 10142 10533 10256 56829 57670 3674 55750 4140 5037 54518 673 8805 5906 5594 5595 4893 5604 5605 4000 11044 3265 5894 10018 8844 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants 8325 8323 54894 4040 89780 7855 4041 8322 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 815 816 4747 817 818 2906 2902 27330 6197 6196 6195 2904 1739 57554 88 5923 1742 808 5594 5595 4893 5170 1741 1740 3265 5924 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 596 10454 842 598 114548 64127 3551 3326 1147 8517 10392 4791 9447 257397 4210 24145 58484 9051 29108 23118 5603 6300 22861 351 4790 10910 10628 5027 1432 834 837 5600 5970 3162 64170 83737 841 6885 8767 5608 7334 7335 7189 7295 835 330 14 3654 3656 1540 7128 329 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin 2232 2230 112812 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs 23220 4791 3661 4793 148022 147945 28512 1660 8737 4790 28511 11035 3551 4792 29110 81030 7098 1147 8517 5970 4615 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis 596 3094 23405 25942 79444 3065 5454 4343 597 192669 23112 27327 26523 27161 192670 57690 4308 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants 598 9846 2322 2885 5292 6777 5781 6776 50507 1026 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines 5928 10919 5929 83852 8370 5931 79918 2146 9739 51111 79813 64324 9070 6839 55729 8726 8968 9869 84444 55870 7468 56950 9757 56979 4791 2122 23067 84193 79723 64754 653604 4790 29072 84787 84661 58508 121536 11091 63976 387893 4297 80854 54904 23512 5970 8085 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells 2255 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis 4074 6844 1212 162 164 81567 27243 408 9829 8673 2647 8907 10717 8905 9146 3312 130340 23431 6456 1174 2799 1522 6845 1785 1213 1211 1777 11154 351 8906 9179 134829 157807 375 10053 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis 6007 6006 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine 389396 116285 219970 348158 92292 10249 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway 59345 5145 3708 3709 6932 5534 5158 5148 7855 7976 3710 51701 8322 4343 7474 2782 192669 8323 23112 27327 26523 27161 192670 57690 5592 10681 5530 5532 2780 2535 2775 5578 808 5330 5331 4772 23236 815 6934 2793 2792 2791 2790 6885 2788 2787 2786 2785 2784 7481 2783 51764 83439 5593 1499 94235 55970 51176 54331 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation 640 5687 5688 5777 3708 5689 3709 5700 5295 5534 5701 2280 5702 5704 5705 3710 6850 5293 2534 3551 5530 5532 1147 118788 8517 5579 930 5478 7220 8454 4793 6233 7409 4790 808 25780 695 4772 4773 5970 7316 4775 5336 6786 80228 23291 84876 6885 10892 4067 84433 4792 10125 8915 27071 4794 9861 5682 5966 4690 5683 5684 8945 933 10768 5685 5686 973 974 5717 5718 5719 29760 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 4893 5693 6654 5694 5695 5706 5707 3265 5708 30011 5709 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM 5432 2247 5436 5440 5433 5441 5438 2263 5439 22916 5434 5435 5437 4686 2963 2962 2246 5430 5431 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 5567 5209 5568 5519 5518 5210 5566 5515 5516 5207 5528 5208 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 113612 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity 7316 6498 60436 6497 8239 23327 4087 4088 4089 142 64750 4092 51592 7311 7314 5494 3065 25937 6233 54778 7321 22938 23439 5594 5595 7050 7323 9612 9611 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition 5347 26271 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels 338567 83795 89822 54207 3776 9424 56659 3775 50801 10089 3777 51305 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 3570 5594 3569 3717 5605 3716 7297 5781 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions 137075 24146 9073 50848 9071 9074 9075 56288 84552 64398 9080 84612 53842 1366 1365 7122 1364 51208 9076 5584 49861 23562 149461 26285 92359 10207 5010 10686 50855 9069 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling 6610 4803 4804 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases 5578 30849 5880 5289 5590 653361 5300 6280 4688 50508 4689 5594 6279 5595 1432 1536 5580 124056 1535 10811 5879 5600 27035 5579 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability 5058 5063 79109 253260 208 55615 5879 10451 3728 857 1495 7410 5062 4846 1499 64223 117145 207 7409 808 3320 1500 2475 10000 57761 5170 1003 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 79796 22845 199857 2720 4597 5373 10610 79868 81849 4351 79053 29929 338596 29880 51046 256281 8128 4758 29906 4759 91869 207063 84920 144245 197258 7264 8790 29926 29925 2762 5372 57171 282969 10402 140838 84620 55907 55808 5476 6489 10020 54344 54187 80896 7903 55343 129807 79644 1798 26503 6483 9526 6482 6484 10825 6487 85365 116150 8869 64841 6480 79947 55577 256435 2673 6675 27090 5973 51005 5238 9945 3098 10559 30815 56052 440138 79087 8813 10195 8818 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism 36 9673 38 26275 586 587 11112 64087 152926 3712 56922 3028 10295 1384 593 1738 594 4329 27034 1629 10249 549 1892 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 4851 54492 54567 6907 26508 2033 57534 5664 5663 3280 3714 55851 9759 6868 83464 55869 84441 9794 55534 388585 892 8454 6233 22938 23385 51107 79718 10046 8841 7316 51564 10013 10014 8850 79885 9978 1024 1387 23493 9734 23462 28514 3516 83933 7311 182 102 7314 9148 6500 3066 3065 142678 2648 9612 9611 4609 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism 216 229 132158 26007 3795 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase 2033 3306 3337 3320 3297 3281 1387 2288 10728 3305 3326 3304 3312 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations 10585 1605 84197 148789 29954 84892 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) 4851 5928 5929 6907 57504 2033 5931 9219 9070 1107 9112 9759 4221 55869 1108 84441 9794 55534 54815 4853 3725 22938 53615 79718 10046 8535 8841 4773 4094 10538 51564 6304 10013 10014 8850 6045 79885 3567 3566 3565 2113 648 7528 6015 3662 23466 51621 1387 1912 1911 5451 5452 9734 2625 3596 80012 57332 84733 6777 6776 6778 2353 3516 83933 3066 3065 84661 2648 11091 9612 4297 6597 9611 57459 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 54516 9617 84340 4539 92399 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 54998 10573 11222 128308 51649 9553 64960 63875 64963 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 64976 79590 64979 64978 23107 28957 64928 7818 57129 51263 29088 51021 54534 51023 51264 51069 84545 5018 78988 122704 92259 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 51073 118487 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 4508 4509 4519 4512 4513 4514 4540 4541 4535 4536 4537 4538 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia 2302 4851 10309 124093 5990 5991 647309 159989 7161 4343 192669 23112 27327 29841 26523 345643 27161 192670 57690 57822 79977 1874 4602 28514 7027 51053 1875 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells 5617 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes 9314 694 2290 857 57060 1027 4087 1026 4303 4088 4089 2309 2308 1647 2660 5934 901 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks 4683 10111 4361 10524 3838 472 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE 64900 85465 23175 10390 9663 64850 23761 162466 1120 55500 55224 5833 1119 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic 9266 8775 8675 27128 22796 250 143187 347517 9342 84342 91949 9950 25839 27314 10228 10652 51272 83548 27333 57511 9527 1523 9609 10466 11311 4122 57589 8774 9827 4905 9321 54734 83452 9570 57134 4121 63908 10905 4124 9382 6811 375 9267 9265 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs 840 842 56616 54205 836 317 331 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion 8243 9126 23047 157570 113130 5885 114799 23244 23063 10735 10274 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling 2247 10818 2251 2248 4893 2255 2252 6654 27006 2254 8074 2249 3265 2246 10817 8823 5781 8817 26281 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm 6431 9984 10250 22794 29107 57187 51362 199746 7919 84324 84248 22916 6427 84321 6426 9939 6429 10212 6428 23165 728343 4686 9877 51213 10189 8189 84271 65109 9631 80145 7175 26097 8563 8683 9775 10482 9295 10569 10921 11338 2733 55110 79228 4116 7307 8021 348995 9883 57122 53981 55746 29894 23279 79023 10762 1977 6396 129401 51692 4927 5903 9688 23225 55706 23636 9972 11097 23511 81608 8086 53371 8480 10898 79902 9785 6430 7884 55339 6432 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency 1051 23645 1649 22809 1054 27102 440 1965 8894 57761 79094 468 1968 2887 467 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs 55746 23279 79023 10762 23165 6396 129401 9631 7175 3836 4927 3159 11168 8021 5903 9688 23225 55706 8815 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants 3815 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation 27092 815 816 59285 817 783 818 2259 2258 2257 2256 6324 6323 6331 29098 6330 6332 6335 6334 6326 6328 6327 9254 6329 59284 6336 11280 55800 808 782 775 59283 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling 4915 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia 2159 2158 2157 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) 3425 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape 51082 10849 6908 4331 30834 8370 902 404672 94239 3013 221830 7343 255626 5440 5441 3021 2966 9533 2965 3018 3017 54145 3014 5434 5435 5437 8331 2968 8337 2967 8334 9014 8335 1022 9015 9013 474382 8341 11335 8342 84172 8970 8347 8348 128312 8345 2071 8340 55766 84295 2068 8968 54700 8338 25885 85236 8349 653604 64425 79101 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 1019 1029 1021 IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex 246330 3551 7334 1147 57161 7335 57162 7189 8517 3654 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers 5928 57504 1106 5931 54623 84844 94239 1107 8175 6749 1108 23350 80349 10946 54815 11198 54145 53615 83443 8331 8337 8334 8335 51639 23168 8341 8342 8347 8348 1728 4780 8345 7975 8340 1387 10291 8338 10285 27123 85236 8349 1499 80205 1665 84991 79577 7182 123169 57459 8313 2033 7341 8370 22827 9219 9112 3013 7329 11325 23451 8932 6925 255626 3021 4654 4656 3018 3017 3014 9646 8099 26038 474382 114825 6632 125997 2203 55205 6929 6941 22806 22807 57592 11335 23613 10263 8970 170394 9640 128312 7026 22850 85509 10951 6628 23394 10320 152485 55766 84295 8968 6938 6634 6633 10992 6636 10262 6635 6637 10523 84181 57680 2538 3481 85409 79843 55636 10664 5105 3066 6627 3065 6629 653604 23450 6638 11091 9879 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 3043 4035 3240 8542 9332 3512 335 259 3263 3250 3040 213 HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC 23659 5321 79887 100137049 283748 255189 8605 56261 123745 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 4851 8454 9978 6500 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 1978 6176 8662 8663 6171 8661 6170 8666 6173 8667 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6181 6230 6232 6231 6234 6235 6227 6229 6228 7311 11224 25873 6188 140801 6187 6189 1981 26986 9349 6191 6193 6192 6194 1975 1974 1973 1983 1977 8893 1965 8894 8891 8892 1968 8890 3921 9669 1967 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification 29126 5687 5688 5689 5700 5701 6048 5702 91445 5704 5705 100128731 10956 51422 51009 595 5562 5564 7415 6400 1460 6185 5571 8454 91319 1459 6184 6233 1457 5563 5565 746 80380 8405 1603 27248 7316 5133 1019 7532 9978 10613 11160 4751 9861 10331 84061 5682 5683 5684 8945 5685 5686 79139 5717 5718 5719 7991 7311 7314 11047 6500 10213 142678 5713 5714 7979 53632 201595 5690 5691 8452 5692 3703 5693 5694 5695 3716 10987 5706 5707 2932 58505 5708 1650 5709 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration 5364 4233 27289 5879 10507 6237 387 2909 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K 5295 2549 5290 4915 627 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins 6710 4897 6711 6712 286 6324 6323 6331 6330 6332 6335 6334 6326 288 6328 6327 6329 57731 6336 11280 55800 287 51332 6709 3897 3785 3786 23114 6708 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle 5058 50618 28964 79834 5295 6711 5296 6714 5063 2185 8239 257106 11060 11180 57514 58480 9815 10298 9146 4690 55789 5062 8027 81839 9231 1213 9352 10254 998 8826 667 23380 1969 8874 6709 4646 50855 8440 9459 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis 3708 3709 3710 4842 7137 476 10060 477 478 1760 53822 53826 7220 53828 480 1193 808 481 487 2281 488 489 482 6543 6546 483 6547 486 490 491 492 493 6717 815 816 817 818 6786 80228 84876 3767 6263 6262 6261 10768 5350 444 5348 5349 10345 5566 6588 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) 3423 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 2697 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling 7316 5094 5300 54476 84282 83737 7322 9246 64135 57506 23586 29110 3093 51191 84166 7187 89122 9636 79671 7318 7706 9641 55593 3661 7311 7314 6233 7321 1540 8887 7128 7323 9140 9474 54941 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation 3674 2147 2266 3690 2243 2165 2162 3053 5270 5104 5624 2244 462 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 84693 5095 166785 4594 5096 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis 1462 1634 10090 63827 633 79586 51363 1463 56548 55790 55454 10675 166012 55501 54480 337876 9469 22856 50515 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation 3082 4233 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 983 5347 991 26271 51343 891 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery 5436 6921 5438 6924 5439 6923 7469 8178 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 51497 11198 8812 25920 5434 5435 51224 5437 7936 2963 2962 904 905 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 1019 894 898 896 1017 5925 9134 1027 1869 1870 1026 7027 1028 1871 595 7029 1021 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives 2877 2876 246 5743 247 2879 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade 146850 3937 5777 388 5294 5295 23533 5336 5296 5880 2207 5290 5291 391 6850 4067 2534 5879 10451 80739 51206 10630 387 8503 7410 5590 998 7409 27040 51266 5170 5781 3932 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) 2914 259296 259295 2911 2918 846 2917 2915 2916 2913 2912 338398 50835 9568 83756 50831 50833 2550 50832 50834 50837 50836 50839 54429 259289 50838 259287 259286 259285 50840 259294 259293 80835 259292 353164 222545 5726 259290 80834 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation 1212 10052 1601 57165 8218 375519 57369 2702 2701 2700 127534 2709 2707 2703 219770 125111 1785 1213 10804 1211 81025 1759 84694 7082 2706 2705 4646 2697 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex 23633 94239 54145 6233 7321 25906 11065 8697 7324 8331 10393 29945 8337 29882 8334 8335 996 51343 51529 8881 64682 7316 27338 119504 246184 8341 8342 51434 8347 51433 8348 8345 8340 8338 3836 9861 5682 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 4176 85236 5718 5719 8349 7311 7314 4171 11047 10213 5713 5714 7979 5690 5691 5692 990 5693 51053 5694 5000 5695 5001 23595 5706 23594 5707 81620 4998 5708 4999 5709 5687 5688 5689 5700 5701 8370 5702 5704 5705 3013 255626 3021 3018 3017 3014 3837 474382 8970 128312 55766 8968 653604 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 7316 2033 60436 6667 3726 5054 4087 4088 4089 1024 4221 4092 1874 5045 1025 1030 892 7311 7314 3065 1278 25937 6233 54778 8812 7027 5594 5595 7050 5933 7029 4904 904 1875 4609 905 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 983 3570 5595 3569 3717 5604 3716 7297 5781 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat 5432 5436 5440 5433 9150 5441 5438 5439 51497 22916 7469 25920 5434 5435 5437 7936 4686 6829 2963 2962 5430 5431 6827 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 1019 1029 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events 1432 4893 7867 5600 5898 5899 9261 3265 5603 6300 5900 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere 5111 6119 10714 6118 2237 5424 57804 1763 26277 3978 25913 65057 7013 641 7014 54386 5425 7486 6117 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency 6948 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication 246243 7156 56652 9941 11232 5428 5442 6742 92667 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation 7316 10062 1175 7376 160 161 163 7311 7314 1213 7436 1211 6233 29116 255738 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis 147179 2268 917 644150 3055 6850 10006 26999 2534 2214 10458 10451 7525 10787 25 7410 4627 10109 10152 7409 23191 71 4650 4651 4644 695 4620 51517 4641 10552 10163 3071 5747 10093 9844 63916 10092 4067 1398 10095 8976 10094 1793 60 10097 5879 10096 10810 4690 7454 7456 55845 998 5594 5595 8936 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 1544 1576 1565 1571 3248 2053 240 1559 2948 246 5743 4056 4048 1543 1558 239 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants 238 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA 51082 3665 22954 2033 81844 3428 147945 11277 197358 2547 11035 3551 29110 1147 8517 4615 5440 5441 4791 4361 9447 9533 51728 4793 27297 28512 661 10623 6233 171568 84265 5434 5591 4790 28511 55703 5435 5437 55718 11128 10622 10621 6737 9208 5970 7316 23220 51428 148022 8737 1387 7520 4792 7098 6778 115004 1499 3661 7311 7314 340061 1660 81030 170506 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors 23236 59345 2899 94235 2793 2792 2791 2790 2782 2788 2787 2786 5330 55970 5331 2785 2784 2783 10681 51764 54331 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins 596 5533 140735 27113 5366 637 7532 7159 5534 7531 90427 7533 8626 10971 7161 208 7157 23368 5599 7534 8655 1869 207 7529 7027 2810 10000 7029 572 10018 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 1795 5879 4915 627 SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 92579 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1019 1029 1021 TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation 10952 9789 200916 9045 7965 23708 5917 2107 23438 57176 25973 51504 55157 3735 6233 80222 7321 10667 79731 79587 2935 1978 51067 8662 55699 8663 124454 8661 23395 8666 57038 8667 10352 8664 92935 8665 54938 57505 27335 3646 51386 7458 8668 8669 7316 10480 1964 64432 6230 65003 6232 64951 6231 65005 6234 65008 28977 6235 90480 51081 7322 6150 6227 55168 64949 6229 28973 6228 65080 51642 54998 10573 11222 128308 51649 9553 64960 63875 9861 64963 64965 5682 64968 5683 55052 5684 55173 5685 64969 5686 51373 5717 26284 51650 5718 51253 60488 5719 51258 7311 219927 7314 11047 29074 10213 10102 5713 56945 5714 28998 64975 7979 64976 79590 64979 5690 64978 5691 23107 5692 28957 5693 64928 7818 5694 57129 5695 51263 5706 29088 5707 51021 54534 5708 51023 5709 51264 51069 84545 85476 5687 78988 5688 122704 5689 65993 5700 64981 5701 10240 64983 5702 3396 5704 26589 5705 63931 6182 54460 6183 51073 118487 116540 740 124995 54148 6746 116541 55037 6748 6747 29093 6731 9801 6730 51116 10884 6729 54948 6726 51318 6728 23471 11224 3376 25873 84164 10973 6188 140801 6187 90850 6189 1981 4508 4509 26986 27068 327 9349 6191 6193 6192 4519 7284 6194 4512 4513 4514 9978 2058 1975 1974 1973 1983 1977 5859 4540 4541 90701 3921 9669 4535 53918 4536 4537 4538 6122 6124 6123 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 6128 6129 6201 23478 6142 6203 6202 6141 6144 6143 6146 6147 6727 6139 6138 6152 6155 6154 6301 6210 6157 6156 6159 6158 51065 7415 6205 6164 6204 6166 6207 6165 6206 6209 6168 6208 6223 6167 6222 9521 6169 5464 6224 6160 23521 6161 6218 6217 6175 6176 6171 6170 7323 7453 6173 16 8565 54516 3035 9617 2193 84340 833 4539 6897 4677 4141 92399 10056 7407 2617 6921 6181 6923 1938 6734 1937 6745 1936 1933 1917 1915 9255 60559 54471 91574 6059 27230 123263 4528 219402 51250 115416 7353 51520 22980 9147 23008 55139 55666 5018 8453 92259 1615 25898 28972 58477 4706 26046 8893 1965 8894 29104 8891 8892 1968 8890 1967 116832 55176 29927 4736 23480 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes 1387 6347 2033 4780 7975 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants 2322 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling 9444 80824 7450 22866 22906 9715 409 22808 1185 3717 3845 1849 1852 1848 1850 283455 54845 2266 8036 7414 3690 2243 7529 8826 11221 808 8087 1445 9061 8315 57085 80853 2244 10827 5908 5245 23164 815 8546 6714 816 55109 7094 817 818 2335 369 27044 5500 4296 408 10142 10533 10256 56829 57670 3674 55750 4140 5037 54518 673 8805 5906 5594 5595 4893 5501 5604 5605 4763 4000 11044 3265 5894 399473 161742 10018 8844 200734 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 10454 5777 6441 30849 64127 26007 567 23165 3605 9631 7175 112744 4153 7555 257397 7097 7096 3320 348995 9883 57122 55746 23279 79023 10762 8767 6396 1387 57506 129401 9871 7334 4927 9632 7335 10427 9868 9641 8678 5289 3661 5903 9688 3654 23225 3656 91662 55706 23636 9972 22863 11097 23511 8086 53371 8480 79902 51311 3665 3442 3441 3440 23367 114548 3439 3452 3451 64135 3449 3551 3448 29110 23586 3326 3446 3445 3444 1147 3443 89122 8517 9636 10392 84818 3456 3454 7706 8021 23118 3107 3106 3105 5648 5781 51128 84282 7297 6885 3134 3133 9908 10146 7187 7189 6773 6772 80143 3135 340061 10802 10484 23765 3716 3838 51284 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate 79947 57171 22845 79644 116150 207063 4597 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) 55630 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 2247 2261 2254 8074 2249 2246 8823 8817 26281 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes 3417 4780 4199 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin 130399 91 10468 92 10589 93 10272 8928 4087 4088 4089 5594 5595 7049 3625 3624 3623 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer 4088 4089 4087 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion 7852 920 1234 5478 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression 204851 8463 2626 28996 8850 25937 7004 7003 7005 1490 10413 6910 4878 1482 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling 3718 3560 6464 3716 2185 3561 3559 6777 3558 6850 6776 3932 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28234 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis 159 10606 3615 2618 3614 5471 471 8833 5198 122622 158 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 5244 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport 6005 57127 51458 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer 4088 4089 4087 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI 1591 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 2034 2247 79727 6657 9314 6774 27022 64344 2041 4087 4089 57167 6299 55211 5087 79923 5460 63978 2516 6997 7547 84891 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants 4893 3265 3845 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 10599 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization 81607 5818 57863 5817 5819 23705 25945 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans 1462 7043 1311 4148 4038 7042 5802 3915 1299 1298 633 1463 375790 3911 3912 7040 3693 3694 3685 1634 3690 2331 7448 8785 5054 63827 4684 54829 3679 3687 7143 7148 176 3673 3339 1834 3908 3913 3910 3674 3371 4593 1297 63923 3381 3909 1758 1404 1605 284217 8516 3688 4060 4146 3680 6678 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) 285195 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 292 293 291 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis 50618 1212 50813 26119 409 10920 7018 8322 7474 185 1601 2873 8218 1950 1956 6869 6233 2060 6453 920 154 6455 7316 6457 156 374 1129 4036 7039 8301 7311 7314 58513 3949 29924 30011 23208 9185 9856 4074 6844 115548 1861 8674 338 6857 27348 23149 85439 9892 22905 917 3267 85021 29988 950 143425 22848 4738 6572 286749 90019 55707 29978 29979 84251 6456 1175 160 161 163 1213 1211 9318 255324 7037 3482 10618 157 2069 685 408 8673 9341 127833 1839 9146 3575 867 1856 8027 25977 6845 10254 8533 915 64708 51138 10987 551 1080 10980 554 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression 983 84930 2029 5519 55844 5518 5515 5516 10776 891 MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation 10128 22868 81892 9238 6832 2926 25996 60493 87178 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors 5739 5731 11251 5737 5732 5733 5734 6915 5729 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function 5947 9227 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis 1589 3972 3284 1585 3283 1081 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 7316 163351 7311 7314 2634 2633 6233 7322 808 3043 4072 837 11045 115361 3040 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development 10891 7533 5443 7306 4343 597 192669 994 23112 27327 26523 208 27161 192670 57690 595 2766 7965 5917 9521 9114 1000 79444 7020 3735 4308 4644 523 526 527 528 4141 529 5977 4233 1029 7532 7531 6934 5054 533 5873 4935 7837 3662 5347 1387 60 605 89780 5077 8110 7545 891 83439 6657 4174 6601 9255 1499 9550 6603 4171 6602 6605 1026 6604 5594 8992 5595 3978 3815 7015 2932 51520 51176 596 22797 86 1908 3094 6932 2033 1906 7341 26039 4157 1910 27022 257 6926 4161 1615 8600 4286 6663 5454 999 3397 4160 7030 6760 1435 4159 7329 427 6591 634 7942 6195 6909 79083 2315 7514 6490 10085 727936 3376 7534 54843 1638 6935 7529 1432 672 8289 57492 23405 1729 1017 5829 25942 2058 5859 23411 9274 9275 3673 25924 51606 7391 7299 4140 8193 3065 201595 6662 10000 6595 6597 6599 6598 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling 8772 843 8795 8837 8743 8793 8797 841 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 2247 1950 2255 2252 2249 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants 79412 27121 22943 27123 4041 83999 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS 3718 5928 57504 23476 2280 10362 5931 51317 9219 6850 1312 1107 2908 10800 9112 3615 3717 10728 29110 3614 3326 1108 8819 476 25855 477 478 3459 3460 3454 53822 5045 1175 53826 160 161 54815 163 53828 7409 480 3320 481 54106 53615 482 23186 483 486 203068 5926 695 5133 5336 4780 2342 9978 2339 7297 79685 8737 2288 6093 10280 3554 4690 6773 3570 973 974 3676 9475 29760 51185 3066 3065 5348 5349 9817 51742 1901 10284 8452 5978 59272 6654 81030 64426 3688 3716 51284 30011 23028 57459 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 4690 5058 6091 9353 5062 5063 6655 56924 57144 6654 5879 10298 8440 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly 5928 57504 7341 8370 5931 94239 9219 1107 9112 3013 7329 1108 8932 255626 3021 54815 3018 3017 54145 3014 53615 8331 8337 8334 8335 8099 26038 114825 474382 125997 2203 55205 6941 22806 22807 8341 57592 8342 23613 8970 8347 10263 8348 170394 128312 8345 9640 7026 85509 8340 10320 55766 152485 84295 8968 8338 2538 85236 8349 5105 3066 3065 653604 7182 57459 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants 3320 2064 11140 55914 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 1978 6176 8662 8663 6171 8661 6170 8666 6173 8667 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6181 6230 6232 6231 6234 6235 6227 6229 6228 7311 11224 25873 6188 140801 6187 6189 1981 26986 9349 6191 6193 6192 6194 1975 1974 1973 1983 1977 8893 1965 8894 8891 8892 1968 8890 3921 9669 1967 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance 229 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes 6888 1387 2033 4780 5226 7086 4097 2539 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 7039 2064 7022 1956 7021 2099 7020 7528 1081 29028 3815 94115 7422 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification 51606 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol 4809 51602 6128 6129 10171 6201 79050 6142 84916 6203 10813 6202 23160 6141 6144 27042 55127 54555 6143 84128 6146 51202 6147 8602 92856 65083 11103 6139 6138 9277 25879 6152 9790 51096 6155 6154 6210 55813 5822 6157 6156 6159 56902 6158 2091 51065 200916 25926 6205 114049 6164 6204 27340 6166 9045 6207 27341 6165 6206 10436 6209 57647 6168 6208 6223 6167 6222 88745 6169 6224 10199 9136 23521 6160 57050 22984 6161 55272 6233 51077 6218 10607 6217 4691 11056 6175 9724 6176 84135 134430 6171 51118 10885 6170 6173 79897 11102 1454 54913 1453 10799 10557 6181 10556 6230 6232 6231 6234 6235 6227 6229 6228 7311 22803 10528 11340 23404 54512 11224 5393 25873 55720 23016 8780 54881 6188 51010 26168 140801 6187 81875 6189 79159 51013 51388 90459 8568 55759 705 118460 79707 22894 57418 23246 23481 56915 26354 55131 81887 84946 55781 117246 83732 10969 9349 6191 6193 6192 27043 6194 10438 5394 10200 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 9188 6137 23517 6136 51121 140032 4736 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling 148738 285704 57453 3983 5747 6714 6478 6477 116986 8976 1793 5588 7204 56963 5879 219699 8633 1630 9423 4690 90249 137970 6091 7430 5335 9353 7220 7222 7224 84448 7223 6586 7225 6585 59277 998 4756 4651 1826 22885 57113 5306 5781 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 6557 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport 7274 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants 2322 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding 2767 10238 59345 10517 6774 26330 898 347733 84261 2769 9134 7278 22948 63971 26985 2782 26224 79861 81027 54461 2776 10528 5203 5204 10681 8877 10564 7157 1460 1459 1457 8841 908 113457 10383 6950 10382 7203 2793 2792 7280 2791 2790 26272 2788 2787 2786 83752 7846 2785 2784 60 26234 2783 51764 10693 6468 10376 10574 10694 10576 2629 10575 80086 26190 26270 7277 9630 94235 51807 6000 22803 8787 10381 7411 8786 55294 112714 55135 55970 9628 84790 10471 5201 5202 6499 5082 84617 11328 54331 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 9738 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 22897 54930 5116 79959 80184 5518 93323 7277 23354 22981 8481 80254 983 121441 55755 54820 10806 10121 5566 55835 55559 8636 11258 84131 4957 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells 4025 4353 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate 6657 9839 6911 5453 89780 5015 6656 25925 2253 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 91603 10714 4331 51426 5424 9716 57804 902 404672 1642 54107 1161 5430 5431 10450 5432 5440 5433 5441 6917 2966 2965 7874 6233 5434 5435 27339 5437 56949 2968 2967 1022 57461 6117 7316 5111 6119 5436 6118 5438 5439 2074 9978 2071 2068 57654 5982 5983 7311 7314 8451 5981 8450 56655 5984 3978 5985 7515 5425 5426 5427 3980 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions 27330 1739 3672 7410 7430 1808 1956 5962 1272 6900 4684 6712 288 24137 5594 5595 5604 5605 284217 3897 3785 3786 3680 6708 5058 100133941 2596 6710 4897 57698 3915 1463 2048 8828 3912 8986 6324 6197 6323 6196 6195 11313 3312 6331 6330 6332 6335 6334 9252 214 6456 6326 8506 1175 160 6328 1460 285643 161 3685 6327 163 6329 26052 57731 6336 3690 1785 1459 1213 1211 11280 1457 1759 55800 287 51332 6386 6709 8650 10048 23114 1641 6711 286 27255 5879 3673 8515 10752 3674 3678 8829 1742 1741 3688 4478 DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME 3251 54490 445329 79799 5444 54659 54658 1244 3615 6783 3614 10451 10249 10 1558 1576 5446 1565 1571 7410 7498 1557 1559 123876 8824 7409 10599 348158 3291 3290 8833 64078 2030 389396 866 7363 7365 3177 7364 9153 7367 7366 55315 54578 54577 54576 54575 6818 6817 213 54579 100 6822 27233 55748 2939 2938 2944 124 4363 124975 95 55270 132 6582 6580 8714 2952 574537 2950 10720 54657 4830 4831 10057 6566 9 590 4860 1645 2987 2678 54600 9429 22978 54988 2687 9376 6581 2686 682 10257 7172 6579 5879 10941 5243 219970 92292 5105 133688 28234 1066 161823 341392 3704 167127 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 9212 23421 51143 25909 9183 401541 54821 9184 64105 23122 991 4085 701 378708 1780 79172 81930 84643 55920 3796 57405 7514 1783 83540 80152 10403 8655 3619 80776 64946 1781 11243 5519 1778 348995 5525 5515 5526 57122 5516 5527 699 11004 5528 5529 91687 57551 140735 55746 79682 11130 25936 9793 332 23332 6232 23279 79980 2491 79023 55839 54908 8379 5347 55143 22919 6396 55166 5048 10726 79019 151246 1063 9735 1060 151648 5905 5518 1062 1058 5903 79003 55055 220134 81565 57082 54820 5501 6249 147841 79902 348235 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 908 113457 347733 10383 6950 10382 7203 7278 7280 22948 79861 81027 7846 5203 60 5204 10693 10376 10574 10694 10576 10575 80086 7277 51807 10381 7411 112714 84790 10471 5201 5202 84617 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression 6908 8341 8342 8970 8347 8370 8348 128312 8345 23378 94239 8340 55766 6839 8968 23411 3013 8338 255626 3021 85236 8349 3018 3017 54145 3014 653604 8331 8337 8334 9014 8335 9015 79101 9013 474382 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer 7316 7039 5295 1950 2549 374 5335 6464 2069 1956 7311 5290 7314 685 6233 3320 4893 6654 1839 3265 255324 11140 867 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants 238 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 6772 6774 8503 5295 5296 5290 4067 2534 4893 3717 6654 3815 7525 3265 6777 6776 3932 CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic 5928 23194 894 896 902 5925 23649 5422 993 994 2801 5557 5558 4149 1870 5933 5934 6117 6119 6118 8317 22974 4067 5982 9861 5983 5682 5683 5684 84515 5685 4172 5686 4173 4174 5717 4175 4176 5718 64785 5719 8318 9837 84296 4171 11047 10213 51659 5713 5714 1026 7979 5690 5594 5691 5984 5692 5985 5693 5694 5695 5706 5707 5708 5709 9212 5687 5688 5689 5700 5701 9184 5702 5704 991 5705 26271 890 8900 4085 701 995 55320 8556 55355 7514 5578 1874 4605 8021 207 3842 1763 387893 6418 5111 332 9978 5862 26003 8548 64151 10592 9918 23397 10051 1859 28227 1163 260334 6683 9798 200014 347688 9088 10776 79648 23383 22933 84930 2029 29781 55844 54892 23310 25836 5424 27243 23165 128866 9631 7175 79643 1104 51652 81876 8815 348995 9883 57122 1719 29082 55746 1032 1031 5861 27183 91782 23279 25978 79023 10762 92421 6396 157570 114799 129401 4927 3930 5905 2237 5901 5903 9688 23225 23592 55706 3978 23636 9972 11097 23511 7083 8086 53371 8480 79902 1876 1875 5520 25909 7341 9183 9232 7329 57405 7157 1460 10403 1459 80776 1457 5519 23047 113130 9700 5525 23244 5515 23063 5526 5516 5527 5528 5529 91687 57551 90381 79596 79682 51400 51451 23175 2010 2491 55143 9126 10735 10726 10274 64900 8243 1063 1060 151648 5885 7298 728642 984 1058 9663 5981 56655 5425 5426 5427 348235 4609 10714 23421 51143 55732 57804 64105 54107 595 5579 6790 8454 9662 8655 7840 6233 7321 11064 1781 25906 3320 22994 11065 22995 8697 7324 7283 10393 1778 10733 29945 80321 29882 203068 55722 996 84962 1454 699 51343 1453 51529 55125 8881 64682 5577 9814 140735 7316 27338 9738 119504 10133 3161 91750 246184 25936 11190 286826 1029 9793 132660 7532 55957 7531 51434 10383 51433 10382 23332 115106 79980 6232 79441 95681 23291 1069 54908 5500 5347 22919 54801 10142 7846 9702 10540 5108 4218 4659 11116 4751 5048 55142 22897 891 54930 8945 151246 5116 9735 79959 80184 5518 93323 7277 9133 7311 7314 6500 23354 22981 8481 80254 983 121441 55755 220134 57082 54820 10806 5501 79866 10121 23141 5566 6241 55835 55559 6249 8636 11258 84131 4957 54821 23122 3326 55920 11243 91754 140609 10783 2305 11130 63943 51512 55839 1028 8379 55166 79019 79003 4926 114791 55055 85378 10426 27175 653784 10000 81565 29922 27229 440145 10844 80097 147841 29935 10926 55388 401541 7153 94239 378708 1780 79172 208 27436 25 1783 83540 80152 54145 3619 64946 6502 8331 8337 8334 8335 1022 8341 8342 8347 113457 8348 8345 7280 8340 8338 10376 80086 64689 85236 1062 8349 51807 8615 10381 22822 91768 112714 990 51053 5000 84790 5001 7465 23595 8290 23594 81620 2932 4998 4999 84617 10112 4331 9493 2033 898 347733 8370 9134 7278 79861 81027 81930 3717 3013 84643 3796 255626 3021 3018 3017 1869 3014 7027 1871 3837 7029 7443 11004 255919 221496 474382 23399 1019 8970 1017 128312 1027 55766 8968 5753 80028 1021 1030 3065 653604 4001 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA 55746 23279 22916 79023 10762 23165 1977 6396 4686 10189 129401 9631 7175 4927 10482 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema 2161 2147 3818 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing 10657 10656 5753 6421 202559 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) 5295 2549 5335 6714 10818 5290 1795 4893 6654 5879 3265 1020 4915 4908 8851 10817 627 2904 5781 7074 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 1017 51433 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 990 5693 5694 5695 5706 5707 5708 5709 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) 6505 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 29780 3987 5829 6251 7016 9459 55742 87 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) 197342 7516 10714 7156 84464 5892 7517 51426 4683 63979 23514 80198 5424 55732 57804 79008 79728 3364 54107 641 51750 10111 4361 472 6233 1763 545 144715 80010 5810 672 5932 11073 5890 9156 6117 7316 5111 6119 6118 5889 83695 1111 580 10524 7486 5982 5429 5983 83990 84126 7311 7314 5981 7979 56655 5984 5985 5888 5883 5884 5425 116028 5426 348654 5427 10635 146956 675 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 5929 6907 9968 57678 9969 8648 10891 5925 94239 9070 729359 123 23054 60481 10555 22976 25 5166 8202 54145 948 58508 8331 8337 8334 8335 84962 1020 84246 8341 8342 8347 8348 8345 8340 79447 1024 1387 8338 9443 9442 2494 9440 85236 8349 9439 22822 1050 2033 8370 51003 6256 8800 10499 51129 9477 3013 90390 10025 255626 7069 3021 63924 892 3018 3017 2167 3014 57104 79718 11343 2180 8841 474382 9370 10001 23175 8970 128312 55766 79611 8968 4023 23411 29079 2874 5346 7403 5469 6319 133522 9282 653604 84661 9862 84649 11091 9612 3991 9611 8085 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 3718 5777 5295 5296 5290 3567 5291 3055 6850 1437 5293 3563 1398 4067 2534 3560 3717 3568 7525 6777 3635 6776 3636 867 8503 7534 6464 29760 1439 1438 2889 7409 7006 1399 9846 6654 5566 3716 3562 3561 3559 5781 3558 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling 7039 1950 4893 374 6654 6464 2069 1839 1956 3265 685 255324 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1387 2033 1499 3661 9208 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle 50619 147179 6510 5295 221178 9912 5296 5290 653361 257106 116984 6655 50508 10006 23526 57144 5585 1536 5586 1535 10458 1894 10451 9815 23092 9938 347902 4810 7410 9710 51291 50649 9826 152273 7409 8826 22899 23191 8997 23075 8874 124056 5924 10672 3071 85440 4162 9855 4168 80728 8773 7444 8976 7204 9743 57584 394 7074 83478 11188 3895 3930 8503 7454 55789 7456 55004 81839 143872 80005 27 998 29 23592 139818 64857 23380 1969 6654 23263 55619 9639 51306 9411 7112 29127 5058 28964 94134 55200 5063 79658 10652 644150 392 23616 393 128272 115703 201176 26999 10788 396 57514 397 57636 10787 143098 10298 57522 4983 23370 25791 857 8476 10152 58504 64411 81624 1124 23344 1123 23580 84144 55114 81704 23348 10395 26230 1795 4650 1794 51347 10979 7037 9459 55914 2909 10160 10163 9732 84904 57572 25894 57679 128239 11135 2010 57569 56924 116985 10928 9341 57580 1793 613 26030 10811 5879 10810 80243 27035 7879 115557 55843 752 5062 182 4688 55845 4689 55971 11113 10144 9901 3688 57480 117289 8936 5337 50855 5338 64333 7984 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping 1857 1856 8324 5599 1855 1535 124056 10811 5879 3725 27035 7474 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO 91653 2619 50846 156 132884 2121 23288 5727 2622 6469 84455 1452 409 408 6608 3549 11127 50937 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins 364 366 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis 143662 118430 10610 4582 4583 6483 4584 6482 4585 6484 4586 200958 6487 727897 6480 256435 27090 10071 94025 140453 4588 4589 283463 56667 394263 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions 6431 5356 10250 3188 3184 51362 199746 9716 3192 3191 6427 3190 6426 8896 6429 6428 10189 10084 8683 8449 9775 23350 9295 9343 10921 56259 11338 80349 7307 10946 3178 10949 4670 3187 10907 10914 5725 1191 9382 3320 27339 83443 3183 7099 7431 253260 23643 79869 8737 57521 57506 4792 4751 9641 8678 5289 1499 2475 6383 10082 6385 22863 6382 79109 221914 9672 2239 1616 3326 55615 3312 4793 2262 64223 1994 2817 6632 5824 1479 1478 1477 6628 57794 8106 6634 6633 11100 2719 6636 10262 6635 3339 6637 10236 6773 23524 115004 57703 340061 6886 4318 23020 85313 7082 9879 335 9410 1655 11051 9416 10181 317772 51585 30849 85235 5093 5094 6141 51593 54623 22916 84844 1993 4686 8175 375790 10015 8189 51503 4153 23601 5430 5431 221613 55696 5432 5433 92815 712 8969 716 721 722 440689 725 56949 8331 5546 8337 8334 8335 2963 2962 29959 5436 51639 5438 23168 8341 8342 8347 5439 8348 51645 8345 8340 10291 8338 51692 10283 8241 10286 10285 55763 8729 85236 8349 27316 1660 1654 1665 84991 2521 81608 79577 10898 55339 123169 4904 10421 285755 8370 22826 22827 6993 54883 64135 7329 3013 11325 55749 23451 255626 10450 5440 7706 5441 2147 3018 3017 54463 53938 22938 5434 5435 23283 5437 23352 24148 7448 9646 53981 51340 57461 57551 27238 29894 815 8970 816 128312 51729 817 818 80273 8968 10992 10523 10978 3181 3185 2194 988 6627 6629 653604 220988 23450 6638 10594 550 9785 6430 6432 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation 7316 10454 7186 64127 841 6885 8767 3551 4792 7334 84166 92610 1147 7335 7189 8517 10392 79671 7157 9097 3146 6285 6288 11274 6283 9683 4791 9684 7311 257397 4793 7314 28512 6233 177 3654 23118 121457 4790 351 28511 3656 80216 5970 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer 238 80304 5777 6774 5295 3726 5296 10818 5290 5925 5291 3667 4343 597 50616 192669 6238 26523 27161 192670 57674 57690 2885 7175 9451 27436 3831 3002 8496 3799 7157 6801 5599 8878 5335 4627 5601 8454 7414 1213 3725 57448 6233 3092 5551 9648 833 10342 7535 7316 2305 1051 6194 9978 2335 1937 4193 7297 29851 3662 4869 5573 471 6776 1786 891 53335 6772 7311 3587 7170 1639 7314 7171 5903 5495 6500 4170 3065 1026 7291 4008 5594 51530 5595 3586 22872 10817 4478 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 9197 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases 9261 6197 6196 6195 4205 4208 2353 51231 2002 1849 5599 1848 9252 1846 1845 5518 466 5601 5602 3725 5594 1386 5519 1432 5595 5515 5516 5600 5528 5598 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription 7003 7005 8463 1490 10413 864 25937 7004 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle 9497 94134 5295 5296 101059918 392 3998 57144 29984 832 10424 23092 144402 26092 857 81624 23344 79180 55114 5361 5364 8987 2909 9217 4162 1729 80728 51479 2010 56924 87 7444 9341 27145 9743 57584 394 7879 55240 84681 3930 55789 9590 81839 120 123720 4001 23592 1627 158747 7112 29127 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling 4690 3983 5747 6714 84448 998 8976 1793 7204 22885 5879 1630 9423 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste 2914 259296 259295 2911 3710 2782 346562 2784 51764 6324 6330 6335 83756 6326 6328 50831 6327 50833 50832 50834 50837 50836 50839 54429 259289 50838 259287 259286 54795 259285 5330 255022 119395 50840 259293 80835 259292 5726 259290 29850 80834 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 1356 30061 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements 5928 79862 57504 340252 5931 7695 7576 94239 22880 1107 9869 51535 65251 155054 1108 162967 162963 7581 147686 54815 91661 6940 54145 55596 284306 23272 53615 9422 8331 8337 8334 8335 197320 5977 10179 8341 8342 8347 8348 8345 25799 8340 84911 60 8338 605 8110 23468 147646 85236 6601 8349 6603 10155 6602 6605 6604 54737 125893 57693 147658 57459 7700 86 26039 8370 79813 9219 55729 6760 9112 162655 3013 7329 6613 255626 3021 3018 3017 3014 8289 90853 474382 10919 57492 8970 128312 81931 55766 8968 9274 9275 90075 1788 7767 113835 8193 3066 3065 653604 143689 55422 10793 6595 23517 7562 6597 285676 6599 6598 29947 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation 2247 2254 8074 2249 2591 2246 8823 8817 26281 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation 4913 4968 8341 8342 8970 8347 8370 8348 128312 8345 8930 23583 94239 8340 252969 55766 26277 25913 65057 7013 3013 8338 7014 54386 6996 255626 79661 55247 85236 8349 4350 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors 22794 6655 9939 65109 9775 200916 5216 10921 5217 9355 9045 8022 23053 55110 23708 6091 4116 26019 56956 3670 23032 2107 89884 65110 4440 6233 6585 3199 1287 2935 7316 80728 6230 23332 6232 6231 6234 6235 6227 6229 6228 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 27 5713 5714 7979 5690 5691 5692 23380 5693 6654 5694 5566 5695 5706 5707 5708 5709 8440 5058 5687 5688 5689 5700 5701 5702 5063 5704 23122 5705 10298 1630 9423 5578 11224 25873 6188 140801 6187 6189 1981 6586 4753 51466 26986 2817 9349 6191 6193 6192 6194 9978 56924 5576 3921 5567 5568 6122 6124 6123 6125 8829 6130 6133 6132 1605 6135 6134 2197 6137 6136 51121 140032 6128 6129 6201 6142 6203 6202 6141 6144 22916 6143 6146 6147 8861 6139 4686 57144 6138 6152 6155 6154 6210 6157 5532 6156 6159 25 6158 51065 6205 6164 6204 6166 6207 6165 6206 6209 6168 7852 6208 6223 6167 6222 6169 6224 6160 23521 6161 6218 6217 6175 6176 6171 6170 6173 6921 6181 6923 998 8453 10486 10487 57522 4650 6714 6387 6092 5879 387 4690 116832 5062 9353 55740 23767 7408 9901 9495 4736 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) 2956 5395 4436 4437 4292 PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway 6120 23729 25796 6888 51071 221823 5631 22934 55276 729020 7086 5226 64080 2539 5634 TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling 10454 3551 6868 29110 9261 7185 1147 55512 8517 8408 257397 6233 23118 7321 10399 7323 7124 7316 10133 8772 7186 84888 25999 90268 8439 841 56928 8737 8717 7322 6885 9530 9099 7332 9641 10273 27005 220213 7311 330 7314 331 10616 142678 56957 7132 7375 6610 55072 81858 1540 9825 7128 8887 329 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 6908 4331 902 129685 6872 404672 54623 22916 6874 6873 4686 6749 6881 6880 5430 6883 5431 6882 5432 8148 5440 5433 6884 5441 80349 6917 2966 51497 11198 2965 6875 6878 83860 8812 6877 5434 5435 2959 5437 2958 6879 2957 2968 9646 2967 1022 2963 2962 2961 2960 5436 6921 5438 23168 6924 5439 4298 6923 85403 2071 6830 7469 138474 4300 8178 2068 6829 27125 55840 6827 9150 1025 51616 25920 54457 51224 7936 55677 79577 123169 904 905 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A 7316 27338 119504 246184 51434 51433 9184 991 4085 701 4751 7311 7314 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 57522 23380 6091 9353 9901 80728 5879 998 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora 7316 378884 2997 7311 2992 5507 7314 7957 6233 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) 81031 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 4851 84441 9794 2033 3516 55534 8850 388585 4853 4855 22938 3280 4088 1387 2648 23493 59 10046 2324 23462 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions 10319 8082 54221 3914 3915 3918 8573 9672 375790 3911 3912 5155 7040 5578 3693 3685 3690 59277 7448 51399 137868 5154 7276 87 3691 1821 3673 3339 1838 1837 3908 2247 8910 3913 3910 6641 6640 3371 3655 1756 3909 6645 7057 9378 780 6383 1605 6385 7402 284217 3688 4921 6382 6443 6442 6445 6444 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation 5058 147179 917 644150 6850 2209 10006 26999 2214 2212 3326 10458 10451 10787 25 7410 4627 10109 10152 7409 3320 23191 71 4650 4651 4771 4644 3984 695 4620 51517 4641 10552 10163 3071 5747 10093 9844 63916 10092 1398 10095 8976 10094 1793 60 10097 5879 10096 10810 4690 7454 7456 55845 998 5594 5595 1072 8936 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 5687 5688 5689 5700 5295 5701 5296 5702 5704 5290 5705 5291 917 3551 1147 3635 8517 8454 6233 50852 23118 7321 4790 920 5970 7316 5728 23291 7322 6885 997 10892 8767 84433 5588 4792 7334 8915 7335 9861 7189 5682 5683 5684 8945 5685 5686 5717 3123 3122 5718 3120 5719 7311 3119 7314 3118 11047 6500 3117 10213 3115 5713 3113 5714 915 7979 916 5690 5691 3127 5692 3126 3125 5693 5694 5695 5170 5706 5707 5708 5709 3932 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs 5058 388 9475 389 79784 4627 5500 4637 10398 1072 3984 3985 103910 4659 6093 4628 4660 4629 387 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions 221935 54549 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 5928 57504 5931 2146 9219 1107 9112 5468 1108 6591 7157 1822 54815 84232 1958 64223 6615 3725 57167 53615 8649 23186 8535 8841 64121 51564 10542 7101 10014 6045 389541 28956 10670 648 6015 57521 153129 23466 6009 8726 1912 1911 10325 80012 57332 84733 55004 2122 3066 3065 2475 5594 1386 5595 5978 58528 23028 23512 57459 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling 7316 10818 10253 8569 867 2247 5518 7311 7314 2264 2251 6233 673 9965 5594 152831 5595 5515 2254 8074 5516 2249 2246 8823 5781 8817 26281 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors 1135 1134 8973 1143 1142 1141 1146 1138 1145 1137 1136 1144 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling 9682 6907 341 2033 346 6257 8648 7376 344 6256 348 4343 192669 23112 27327 54659 26523 347 27161 29116 192670 8204 57690 2874 64241 19 5346 64240 10062 6319 2172 2194 5105 79718 80820 9619 221656 9612 1071 10123 27329 9611 23028 8841 55818 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs 10818 57498 1398 9261 53358 6464 7867 5898 5899 4914 25759 6014 6016 5603 2889 6300 5900 7529 673 4803 5906 5594 1432 5595 1399 4893 5604 5605 6654 5600 3265 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins 4803 5046 5045 5125 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 8605 56261 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) 6119 7156 6118 4683 2067 5893 3364 83695 580 641 10524 7486 25 5982 5983 83990 84126 10111 4361 472 1763 545 2072 144715 80010 3978 5984 5810 5985 5888 672 5932 5883 5884 116028 11073 9156 6117 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria 140735 5599 90427 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis 7316 80824 26276 2023 567 4057 57674 3836 4360 6421 9146 51606 11151 7879 5868 4843 1511 7311 7314 7097 6233 5230 2931 5987 3837 5594 5595 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation 3665 3442 3441 7186 3440 2033 3439 84282 3452 10010 3451 64135 3449 1387 57506 3448 23586 29110 3446 3445 3444 3443 7189 89122 3456 80143 7706 9641 3661 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin 8243 9126 23047 5885 23244 25836 23063 10735 23383 10274 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility 3082 10319 5908 4233 85440 2549 5747 6714 3914 3915 3918 64759 84951 1398 3675 3911 3912 5879 3673 3908 3913 3910 3909 2889 5906 1399 284217 3688 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins 8644 5948 338 51109 83875 7274 344 9227 345 154807 348 151056 338328 7276 29967 221914 9672 4035 1109 4036 2239 5947 4023 375790 2719 54884 3339 1208 79001 29914 53630 2262 1645 26020 3949 6383 10082 57016 7804 6385 5406 55937 335 6382 336 337 2817 5950 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle 4190 79751 8402 4191 2806 2805 10165 8604 83733 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins 955 956 957 377841 57089 9583 953 954 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) 60482 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle 25963 50619 9138 5295 537 9912 5296 257106 116984 79822 11214 23526 6793 114822 5585 5586 1894 10451 91452 23092 10211 3728 23779 7410 51291 50649 54443 50650 9826 9824 90627 9828 7409 8826 22899 8997 8874 23197 5924 8987 3163 9217 4162 4168 80728 8773 7204 9743 57584 6093 394 29941 7074 57449 85415 83478 3895 3930 6242 55789 9754 81839 84317 143872 9748 29 2319 23263 8086 9639 9411 7112 29127 9414 65124 9181 55200 79658 23365 23002 10652 3998 392 393 128272 395 396 57514 397 57636 55219 64283 10424 57522 23256 4983 23370 25791 857 5825 58504 64411 81624 89839 6811 70 10395 708 4650 1794 10276 55701 65992 5099 4649 7037 55914 2909 10160 25894 55831 128239 1729 57569 116985 55160 284119 91010 9341 57580 613 26030 80243 387 115557 93663 9475 10134 2040 55852 11113 10144 117289 5337 84986 64333 7984 343578 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 57492 86 2033 28996 6045 26053 648 6015 23466 1912 1911 84333 861 80012 55193 57332 84733 865 10138 51412 23429 1460 6601 6603 1459 6602 1457 6605 196528 6604 6595 8289 6597 8535 6599 6598 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs 5058 388 389 8370 7533 10971 94239 10499 367 995 5585 5586 3013 4628 4629 255626 23081 94274 7534 3021 79784 4627 3018 3817 3017 54145 3014 7529 2810 4637 8331 10398 8337 8334 8335 103910 4660 474382 8341 8342 7532 8970 8347 7531 8348 128312 8345 8340 55766 5500 8968 8338 4659 5879 354 29941 387 85236 8349 653604 5170 23028 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization 128486 161247 1149 345275 63924 29923 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen 51706 759 606495 3043 51167 51700 760 762 6005 3040 358 6521 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling 2812 7450 2316 2815 7534 2814 5295 2811 5894 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 23428 3684 58494 5777 5295 5296 4973 5290 5291 23759 9056 9057 4072 23657 9463 1084 56301 7102 7525 11136 7040 5335 2886 481 482 483 8795 8793 8797 3689 4067 6520 3512 51206 8832 6402 5196 3655 1525 6383 6385 6654 6382 120425 3897 4267 50848 338 1048 54210 9672 2534 634 3635 5478 5175 6566 857 10461 3685 2147 3690 5197 7056 5624 5627 2817 10544 57126 5781 2621 2207 2335 682 960 3675 7441 440533 914 83700 5670 3687 5671 5672 3683 5673 965 6401 90952 5675 5669 4680 5680 961 9123 972 29802 6403 5676 5678 6404 3676 2734 3678 7010 3543 9046 1088 83953 6464 8140 140885 23539 284 285 2995 2994 2888 51378 962 4312 2993 6693 83692 4282 55423 51744 4893 3688 3265 4099 3932 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes 4802 27113 2033 1649 65018 6794 356 4303 2309 1387 2308 604 10370 4800 4801 10018 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival 7316 8878 7311 4804 7314 6233 3654 4790 4803 3551 4792 7189 5970 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 596 4851 5687 2940 598 5688 5689 6347 3417 2033 5700 5701 4363 5702 5704 5705 6649 4097 4199 8714 23657 8878 10061 1950 8454 6233 4790 5563 9429 140809 5226 5970 7316 3162 6888 1029 6667 374 5154 1728 4780 7975 9978 5052 1387 2539 9861 84181 5682 5683 5684 8945 5685 7296 5686 2729 5717 7295 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 2730 9817 5690 5691 5692 5693 5694 5695 2938 7086 5706 468 5707 2932 5708 5709 4609 571 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins 55746 7341 23279 8554 79023 4193 5371 10762 23165 6396 51588 129401 7329 9631 7175 4927 8021 5903 9688 7428 23225 5987 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response 4939 8638 2316 6041 6059 4940 23586 201626 4938 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium 1258 117177 55763 8729 6010 55770 23265 50807 378 60412 8766 54536 10640 4218 11336 9727 149371 1262 1260 5310 5311 SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection 6441 6201 30849 6203 6202 5094 7533 5925 26007 3437 3434 3433 83666 84875 27243 5589 11035 128866 7405 6210 861 51065 7415 6205 6204 6207 6206 6209 6208 6223 79643 6222 3178 51652 6224 23193 9360 7428 6233 29108 6218 6217 4790 834 29082 5970 7316 7532 6667 7531 6230 91782 6232 6231 25978 6234 64398 6235 4088 6227 1915 4089 6229 4869 92421 6228 57506 6483 4792 6482 6484 11123 6487 6480 256435 27090 9868 9641 9111 8678 5289 5479 3661 7311 7314 85437 81631 3656 7113 59272 5170 5706 143 2932 79668 821 598 2033 7341 114548 2280 2589 54956 10971 10610 64135 29110 23586 7329 5478 7706 7534 857 1514 10465 6188 6187 6189 7529 2931 2810 3837 54625 7841 6191 6193 6192 6194 83737 3921 7187 7189 80143 684 340061 4245 56965 2197 140032 3838 1655 51284 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 2998 8908 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence 4174 3978 672 7015 4171 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 7316 5687 5688 5689 5700 5701 4780 5702 5704 9978 5705 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 2932 5708 5709 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism 112937 3074 3073 79411 2720 89944 4969 11046 6483 79369 6482 6484 176 9469 10678 6487 10331 4958 11081 2799 2683 2588 4166 11041 2331 9334 9435 5549 9331 8534 23563 8703 10402 8704 4060 8702 93010 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport 6248 6584 5002 6583 6582 6580 6563 8170 55244 115286 146802 85413 55356 861 6581 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) 6521 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 146850 5294 5295 5296 10818 5290 5291 391 2099 3667 5293 2534 5155 118788 2323 930 5159 6801 940 5156 1950 941 2322 942 2064 1956 2264 2251 50852 7409 9965 152831 9846 255324 9542 5781 3082 3084 4233 2549 23533 374 6714 2069 5880 685 2100 2248 10718 2255 2252 27006 1839 5879 4915 627 2247 145957 7039 8503 3815 2254 4916 8074 8660 2249 4908 2246 8823 8817 3932 26281 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs 5864 81846 22878 208 22879 79090 221960 79890 57589 2665 80006 2664 51209 51762 23682 51552 10890 5870 8408 10260 6764 9909 84315 160518 207 27095 163259 126432 81876 26130 3257 6305 27342 79958 201627 338382 163486 201475 51399 1122 117177 7109 6399 57679 5861 11021 7531 51560 1121 25782 57706 5872 5873 11031 126003 58485 23258 79961 51693 5869 116442 60684 122553 23011 4218 10981 5866 84079 5878 9827 22930 22931 7879 5868 22898 54453 55667 27147 83696 5874 54734 51622 259173 89781 9610 414918 51112 10000 9367 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 8320 6862 2260 6615 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 4436 4437 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression 2034 2908 27043 3091 5753 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases 8496 8500 22865 5802 11141 5792 8495 4916 26050 94030 114798 8541 84631 8497 5789 84189 139065 8499 26280 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition 5928 23194 902 993 994 6790 8454 9662 8655 7840 6233 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1022 84962 1454 51343 1453 55125 5577 9814 7316 9738 10133 3161 91750 11190 286826 9793 132660 7532 55957 7531 10383 10382 23332 115106 22974 79441 95681 23291 1069 5500 5347 22919 54801 10142 7846 9702 10540 5108 4218 4659 11116 4751 5048 55142 9861 22897 5682 891 5683 54930 5684 8945 5685 5116 5686 79959 80184 5717 5518 93323 5718 7277 5719 9133 7311 7314 11047 6500 10213 23354 5713 22981 5714 8481 7979 80254 1026 983 22822 121441 5690 55755 5691 54820 5692 10806 79866 5693 10121 5694 5566 5695 55835 7465 55559 5706 8636 5707 11258 84131 5708 4957 5709 5687 5688 5520 4331 5689 2033 5700 5701 5702 5704 5705 890 8900 995 3326 55320 55355 7514 7157 4605 5519 5515 5516 90381 79596 2305 51400 51451 1017 63943 51512 9978 80028 1063 28227 151648 728642 984 9088 114791 85378 10426 27175 653784 29922 27229 440145 10844 80097 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters 5442 64216 7978 7019 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass 9100 7316 5111 6119 83932 10714 55666 6118 9768 124739 51426 5424 7320 57804 9978 1642 54107 9246 5980 10459 5982 7415 51455 5429 5983 9636 7318 7706 11201 7311 25898 57599 7314 8451 7398 6233 5981 56852 8450 56655 5984 5985 51514 5425 5426 7353 5427 6117 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors 1135 1134 8973 1143 55584 89832 1142 1141 1146 1138 1145 1137 1136 1144 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions 400569 3442 3441 9968 3440 2033 9969 3439 51003 23389 221914 9672 55090 3452 1524 9477 3451 9246 2239 64135 3449 3448 375790 23586 25820 90390 3446 51191 3445 9412 23097 3444 3443 10025 9636 3456 3454 7706 219541 892 2262 7097 6233 80306 4939 55588 10332 10333 9441 2817 84246 7316 51586 7099 929 6921 10001 8341 81857 5610 6923 23643 9978 7297 30835 1024 1387 57506 112950 2719 7098 54797 9443 3339 29079 9442 6773 9440 4131 5469 8678 3661 7311 10134 9282 7314 9439 6383 10082 6385 9862 8065 3716 6382 6837 51284 SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes 378807 117144 117155 79820 157855 57828 84329 347732 257062 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement 5687 5688 5689 6774 5700 5701 5702 5704 5705 999 3717 1009 84231 3728 1508 1495 7410 1514 50649 7414 6233 4790 1500 79872 1520 127544 5970 7316 3569 9855 6714 7297 9844 1793 5879 9861 7074 5682 5683 3570 5684 5685 5686 5717 5718 5719 1499 7311 7314 331 11047 10213 5713 3572 5714 998 7979 5690 5691 5692 329 5693 5694 5695 3716 5706 5707 5708 57531 5709 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 2157 8460 8459 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling 10542 84335 6194 2280 55004 389541 64223 1981 29904 28956 10670 1975 57521 153129 2475 6009 1978 1977 8649 58528 10325 64121 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling 5780 5777 5784 6774 10068 8809 27178 5783 25930 26095 5782 59307 4088 84867 834 5778 29110 5775 26469 5781 5771 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 4851 5687 5688 5689 6932 2033 5700 5701 5702 5704 57154 5705 3280 9759 595 861 6046 864 865 7040 3845 7157 84441 9794 55534 25937 6233 22938 463 2309 10413 10046 7316 1029 8850 6714 6934 4193 7004 7003 4088 7005 4089 1490 1387 6696 64750 3683 9861 83439 5682 5683 5684 8463 5685 5686 3676 5717 3516 5718 5719 1499 7311 182 7314 11047 10213 5713 5714 1026 7979 5690 5691 5692 2648 5693 5694 5695 5706 5707 5708 5709 10018 4609 51176 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 5058 5687 5688 5689 5700 5701 896 5063 5702 5704 5705 3337 4343 192669 23112 27327 26523 5896 27161 5897 192670 57690 3315 8556 8555 148170 7514 10642 2118 989 5596 5597 8202 3725 6233 2309 2308 8997 7316 10435 8550 5879 10602 9861 5682 5683 5567 5684 5685 5568 5686 5717 5062 5718 5719 7311 7314 11047 10213 5713 5714 998 7979 983 5690 5691 5692 5693 5694 5566 5695 5706 5707 5708 5709 4609 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 1460 5499 1459 1457 5500 5501 5187 8864 8863 1020 1454 1453 1408 1407 UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle 7157 1373 5009 383 162417 445 435 57407 384 10166 23408 83884 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 1836 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) 11136 6519 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones 83729 2488 3626 3625 3972 3624 3623 94115 7252 1081 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer 5294 5295 3164 5296 10818 5290 5291 3667 5293 208 5156 1950 2064 1956 2251 7409 3082 4233 2549 23533 374 253260 4193 2248 2255 2252 27006 4915 627 7039 7249 8503 1026 2475 3815 5170 4916 2254 8074 2249 4908 2246 2932 8823 8817 572 26281 146850 842 79109 391 2099 2534 55615 5155 1147 118788 2323 930 5159 6801 84335 940 941 2322 942 2264 64223 6199 207 50852 2931 9965 2309 152831 2308 9846 255324 5781 9542 3084 6714 2069 5880 5728 1027 685 2100 10718 1839 5879 145957 2247 4303 10000 8660 3932 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly 5928 23421 8370 401541 5931 64105 94239 378708 79172 3013 55320 51773 55355 255626 11339 387103 54069 80152 8607 3018 3017 54145 3014 64946 8331 8337 8334 8335 474382 91687 79682 8341 8342 8970 8347 8348 128312 8345 8467 2491 55839 8340 55766 4869 8338 55166 79019 1060 85236 1058 8349 201254 57082 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE 79887 255189 50640 254531 50487 30814 8398 8399 5320 5321 5322 117245 283748 54979 10162 5319 123745 5920 100137049 26279 154141 81579 129642 8605 22925 11145 63874 64600 57110 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) 5687 5688 5689 5700 5534 5701 2280 5702 5704 5705 3551 5530 5532 1147 8517 5579 5478 8454 4793 6233 4790 808 25780 4772 4773 5970 7316 4775 23291 6885 10892 84433 4792 10125 8915 4794 9861 5682 5966 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 4893 5693 5694 5695 5706 5707 3265 5708 5709 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG 9489 23646 122618 114971 8760 5337 201164 5338 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 1544 1576 1565 1571 1559 1558 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity 11254 METHYLATION%REACTOME%R-HSA-156581.6 Methylation 1544 191 57412 4552 51504 4548 7172 1312 27430 29104 4837 9446 4143 4144 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation 673 4803 5906 1398 4914 57498 7529 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 1019 1029 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion 2767 948 23236 5330 2776 5331 2182 2181 9630 2769 2864 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein 7841 4249 51201 51125 100128731 25834 10610 253832 79844 5589 6483 6482 6484 6487 25921 84061 6480 256435 55741 27090 11282 11320 6185 7991 29801 23193 4245 4124 2530 51304 6184 201595 3703 11253 746 51114 58505 1603 1650 4247 821 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation 506 509 6770 2271 3419 3418 54995 4976 197257 6472 29928 51142 5832 56910 1891 26519 26520 8192 10845 10440 8801 1431 522 5162 5163 539 5160 55699 36 292 38 293 3158 384 1738 50 211 217 55173 115209 219 27166 7385 51079 3313 5566 27429 10476 5019 64983 4200 6182 3033 5096 4191 3028 27089 4695 1327 51116 51499 1629 4967 1329 1632 9361 4508 10632 56652 91689 6687 10939 23203 4512 3329 4513 221154 7019 10730 6742 4540 4719 4541 4712 4535 4536 9377 2235 4722 4723 133686 622 27034 2746 10965 4731 498 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease 6774 5295 10818 5290 22916 1523 4686 26127 399687 5430 5431 5432 5440 5433 5441 5335 2264 2251 5434 5435 5437 9846 7750 2963 2962 9208 5436 5438 2549 5439 11160 9530 2248 613 2255 2252 27006 11116 6777 6776 2247 6772 2263 2261 2260 8805 4893 6654 2254 8074 2249 3265 2246 11052 8823 8817 26281 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism 166785 4594 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU 2328 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade 10454 64127 11035 51231 1849 1848 1846 1845 4791 257397 8454 6233 7321 351 4790 7323 5970 7316 7099 10133 929 8772 7186 353376 23643 148022 23291 841 8737 7322 8767 4792 5608 7334 7335 2353 8945 9641 5518 3661 7311 330 7314 6500 3654 3656 5594 1386 5595 5604 329 3665 10010 3551 29110 9261 6197 84166 6196 92610 1147 6195 4205 8517 4208 10392 79155 79671 7157 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 3725 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 5781 6885 7187 7189 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer 5594 5595 5295 5296 6249 5290 5291 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 908 113457 347733 10383 6950 10382 7203 7278 7280 22948 81027 7846 5203 60 5204 10693 10574 10694 10576 10575 7277 10381 7411 84790 10471 5201 5202 84617 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 59345 94235 2793 2792 2771 2791 2790 2782 2770 346562 2788 2787 64805 2786 55970 2785 2784 2773 2783 10681 51764 54331 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 7039 1950 374 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 145957 3084 1950 2064 2069 1956 685 10718 4893 6654 1839 3265 9542 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) 81793 7100 51135 4615 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation 51143 1780 1783 8655 1781 375 1778 5641 5476 140735 6712 6396 3112 10540 3111 9871 3109 3108 9632 1075 93661 10427 55860 1512 1510 24137 1519 1062 8722 64837 1639 26153 10120 51164 147700 83547 84516 10437 10671 22920 10121 22872 11258 29127 10112 821 9371 9493 829 114876 81930 84643 830 832 3796 3797 3831 3798 3832 1509 3799 1508 6456 3835 1175 1514 160 285643 161 1513 163 26052 1785 1213 1211 1759 1515 56992 1520 89953 11004 10053 162 51128 164 11127 8907 8905 3902 130340 7879 972 1174 3123 3122 3120 3119 3118 3117 3115 3113 10802 10484 3127 3126 3125 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus 90809 5305 8396 79837 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins 104 103 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor 5739 59345 94235 2793 2792 2791 2790 2782 2788 2787 2786 55970 2785 2784 2783 10681 51764 2778 54331 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle 50619 147179 5295 221178 9912 5296 27237 101059918 257106 116984 153478 23526 57144 10458 1894 10451 9815 23092 3728 29062 144402 7410 51291 50649 9826 90627 8826 22899 6453 8874 56990 5924 10672 10435 85440 4168 80728 8773 4296 8976 7204 9743 57584 23048 394 7074 83478 3895 3930 55240 7454 55789 7456 9754 55004 81839 143872 23513 998 29 9644 23268 139818 64857 23380 23263 55619 221472 9639 51306 9411 7112 29127 5058 28964 5063 79658 23365 23002 10652 644150 392 393 128272 115703 201176 10788 396 57514 397 398 121512 84364 10298 148170 57522 4983 25791 857 23229 8476 124997 58504 64411 81624 89839 1123 23580 55114 81704 23348 10395 4650 114793 7037 9459 2909 10160 9578 57572 26084 25894 128239 11135 57569 56924 116985 10928 91010 2245 9341 57580 613 26030 92799 10602 80243 7879 115557 752 5062 54874 2040 26286 51133 89846 9901 57480 85360 117289 5337 50855 64333 7984 343578 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants 145957 3084 1950 5335 2064 6464 2069 1956 685 3320 10718 4893 6654 1839 3265 9542 11140 55914 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction 3768 3784 3708 3709 59285 3710 7137 2259 2258 2257 2256 476 10008 10060 477 29098 478 1760 53822 53826 7220 23630 3741 53828 25937 480 1193 808 30818 481 487 2281 488 489 482 6543 782 483 6546 486 6547 490 491 492 493 6717 59283 27092 3767 6263 10142 6262 6261 10768 9424 5350 3775 9254 10089 59284 444 5348 5349 10345 5566 6588 4842 6324 6323 8645 3770 6331 56660 6330 338567 6332 204851 83795 6335 60598 6334 89822 2626 54207 6326 3776 56659 6328 50801 6327 6329 6336 11280 55800 80333 30819 3750 3751 3752 30820 6910 4878 775 1482 815 28996 816 8850 817 783 818 6786 80228 84876 4880 4881 4882 4311 10699 3761 3759 3777 51305 3753 1066 3757 9992 23704 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence 5928 5931 5925 94239 4343 192669 23112 27327 26523 192670 57690 54145 472 6233 1870 7321 4790 25906 11065 8697 7324 8331 10393 29945 8091 8337 29882 8334 8335 996 27287 51343 51529 8535 8881 64682 5970 7316 27338 119504 1051 246184 1032 4194 8341 1031 1029 8342 3569 2114 8550 51434 6667 8347 51433 6045 8348 8345 2113 648 4193 8340 6015 3490 23466 3009 3008 3007 1912 3006 1911 3005 8338 3024 5608 10524 80012 57332 84733 23523 3159 2353 23043 85236 8349 7311 7314 50488 9448 1026 5594 5595 8290 29855 6774 4683 898 8370 4217 2146 25842 9134 79813 890 8900 3397 2077 26277 25913 65057 3013 7013 7014 54386 9261 6197 6196 6195 255626 7157 3456 3576 5599 3021 5609 10111 6416 4361 5601 7867 5602 3018 5606 1869 3017 3725 3014 7027 1871 1432 3552 7029 5600 5598 474382 10919 1019 8970 1017 128312 1027 55766 8726 8968 7290 1021 57634 7295 1030 653604 4001 23135 23512 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange 6119 7516 7156 6118 5892 7517 5889 4683 79728 3364 83695 1111 580 641 10524 7486 5982 5983 83990 84126 10111 4361 472 7979 1763 545 144715 80010 5984 5810 5985 5888 672 5932 5883 5884 116028 11073 10635 5890 9156 675 6117 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane 55300 55361 4952 30849 5289 22908 5297 5298 7179 55697 5286 375 5288 200576 56623 377 9896 93492 DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE 4552 4548 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins 9397 7316 93343 7251 79720 137492 7311 7314 51271 6233 55048 89853 51160 155382 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 1019 1029 1021 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 23385 51107 55851 5664 83464 5663 4854 4904 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript 5436 6921 4331 5438 6924 5439 6923 902 404672 22916 2071 7469 8178 2068 4686 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 2966 51497 2965 11198 25920 5434 5435 51224 5437 7936 2968 2967 1022 2963 2962 904 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers 5928 57504 1106 5931 54623 84844 94239 1107 8175 6749 23506 65980 1108 29998 64919 55274 55193 23350 80349 10946 54815 11198 54145 196528 53615 83443 8331 8337 8334 8335 5977 51639 23168 8341 8342 8347 8348 1728 4780 8345 7975 8340 1387 60 10291 8338 605 8110 10285 27123 85236 6601 8349 1499 6603 80205 29117 6602 6605 6604 1665 84991 79577 7182 123169 57459 8313 86 2033 7341 26039 8370 22827 9219 6760 9112 3013 7329 11325 23451 8932 6925 255626 3021 4654 4656 3018 3017 3014 9646 8289 8099 26038 474382 114825 6632 125997 2203 55205 6929 6941 22806 57492 22807 57592 11335 23613 10263 8970 170394 9640 128312 7026 22850 85509 10951 6628 23394 10320 152485 55766 84295 8968 6938 6634 6633 10992 6636 9274 10262 6635 9275 6637 10523 84181 53335 57680 2538 3481 85409 51412 79843 55636 10664 8193 5105 3066 6627 3065 6629 653604 23450 6638 11091 6595 9879 6597 6599 6598 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK 10542 389541 28956 10670 57521 51422 153129 6009 10325 92335 5562 81617 5564 55437 7248 7249 6794 55004 5571 64223 5494 53632 2475 5563 8649 5565 58528 51719 64121 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 54716 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 5687 5688 4331 5689 5700 5701 8370 4004 902 5702 5704 5705 4005 94239 7161 8861 2624 2623 3013 861 865 25 255626 6688 3021 3018 3017 54145 6233 3014 8331 10413 8337 8334 8335 1022 474382 7316 6929 8341 8342 8970 8347 8348 128312 8345 83737 8340 55766 8968 6938 8338 2625 9861 5682 5683 5684 4602 5685 5686 5717 85236 5718 5719 8349 7311 7314 11047 10213 6886 5713 5714 653604 7979 5690 5691 5692 5693 5694 5695 4297 5706 5707 5708 5709 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage 7378 3251 1633 270 51292 7371 271 100 272 151531 1890 54963 4860 132 83549 978 161823 7084 7083 353 2766 1716 8226 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI 5111 7316 6119 6118 11201 7311 7314 6233 5981 5984 5985 5980 10459 5982 51455 5983 6117 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus 10000 208 2309 2308 3164 6199 207 4303 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling 111 112 156 113 3708 114 5137 814 3709 115 5153 815 5136 5613 816 817 818 3710 196883 5582 5580 5573 5575 5576 107 108 5567 5578 10768 109 5568 5335 808 10645 5581 84254 5566 3838 26960 5577 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 10062 8204 7376 6257 6319 6256 2194 27329 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis 2232 83930 2230 112812 1583 706 9256 147323 10948 6770 134429 231 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 239 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway 5699 9554 5687 5688 811 10952 5689 5700 5701 5702 5704 5705 567 6279 3551 6271 1147 8517 4615 3146 6890 6892 6891 2266 6280 7097 6233 2243 7096 948 3107 3106 3105 6810 10333 695 2244 7316 7099 929 23643 8773 3134 3133 8673 9341 114609 2923 9861 5682 5683 5684 5685 5686 5717 3135 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 55176 5706 5707 29927 5721 5696 5708 5720 23480 5709 5698 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 2322 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 4802 3309 7184 811 22926 1649 468 4800 4801 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling 10454 3708 3709 5295 5534 5296 5290 5291 3710 5530 10451 5532 7410 5335 257397 8454 6233 7321 7294 7409 4790 808 695 4772 5970 4773 7316 5336 23291 7322 997 10892 4067 84433 5588 4792 10235 115727 10125 7334 8915 7335 9861 7462 5682 5683 2353 5684 8945 10768 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5594 5691 5595 5692 5693 6654 5694 5695 5170 5706 5707 5708 5709 5058 5687 5688 5689 5700 5701 5702 5704 5705 6850 2534 3551 1147 4214 8517 5599 5609 6416 5601 5602 3725 23118 7006 9846 9402 3937 4775 2207 2206 2205 6885 5879 7189 5062 4893 3702 3265 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 10454 64127 59307 11213 6279 6271 51231 1849 1848 1846 1845 4791 257397 8454 6280 7097 6233 7096 351 4790 948 10333 695 5970 7316 7099 929 7186 23643 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 2266 5602 4793 5606 28512 57161 3725 57162 2243 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 2244 6885 114609 7189 51295 8651 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism 1462 2990 23553 3373 8372 112937 3074 3073 3425 79411 411 2720 63827 3423 633 89944 51363 1463 56548 10675 55790 55501 337876 9469 92126 113189 1634 10090 79586 55454 166012 29940 54480 22856 50515 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic 9554 2803 51143 9342 1780 1523 11311 57589 4905 26958 10139 60592 55850 1783 84316 400 51014 8677 9321 10945 339122 23423 372 51542 7110 381 8655 662 10244 23647 79571 1781 9382 9276 81876 9712 90196 11316 375 122830 377 1778 60561 60560 22818 6293 2800 1314 54732 51226 738 9267 53407 9265 22820 9266 140735 55275 8675 51594 27128 11014 22796 250 143187 5861 347517 84342 51560 91949 25782 9950 6836 25839 27314 10228 378 51272 83548 27333 57511 9527 9609 10466 10540 10226 55738 8774 5048 9827 93661 22930 22931 10972 55860 9585 8729 23046 24137 54734 1062 64837 83452 1639 26153 63908 51164 147700 84516 11015 55605 10671 22920 55614 10121 146909 55582 11258 23303 29127 10112 9371 4074 221458 9493 9183 8674 547 2589 829 10652 55083 81930 84643 4122 830 832 3796 84364 3797 113220 3831 3798 51209 3832 3799 3833 3834 5870 3835 90990 285643 9570 23095 10749 6811 56894 124602 10959 56992 22836 89953 9648 11004 64147 8775 3482 1315 10618 8398 2590 636 23299 5321 5050 5049 9341 11127 57134 4121 10905 4124 26286 9367 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease 6888 22934 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) 2990 SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF 5921 6774 5295 5296 5290 5291 1299 1298 5155 5159 5156 5045 5335 2886 1287 5781 5340 7059 80310 7060 6714 256076 5327 9564 1398 7058 6696 1286 6777 6776 1285 6778 4690 1284 6772 1282 1297 5782 131873 7057 2889 1293 1292 1291 1399 4893 6654 3265 8440 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage 3251 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 5395 4292 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle 8500 10815 6854 6853 6844 6616 5864 10497 9256 6857 6571 6804 8541 8497 22999 8224 8499 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding 5518 1452 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling 6809 3588 5657 9235 6844 6616 6813 836 163702 200081 7297 3603 5803 1440 1435 282618 1441 920 1436 6382 3716 146433 6810 6804 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation 10196 151194 22944 79091 6187 399818 79823 254013 221143 1938 196483 2109 79609 808 1915 3312 7415 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway 111 109 112 113 196883 114 115 2774 107 108 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane 7478 1452 4040 7855 4041 8321 7471 1855 1455 89780 2535 1857 1856 857 5518 1499 8312 23401 5519 324 10023 5525 5515 5526 5516 5527 2932 5528 139285 5529 7479 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 25979 8540 8443 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling 208 5140 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism 341 5034 346 7376 338 4547 26119 344 8720 345 348 51129 29116 8435 57552 51599 4864 6646 255738 3988 10577 2 19 10062 5045 1175 160 161 163 1213 7436 1211 3069 6233 23491 91289 55908 9619 3990 1071 5125 319 64788 27329 4018 26291 7316 51128 51360 81693 338328 8029 9388 3931 55911 4023 116519 213 5567 84699 5568 5046 7311 29801 7314 3949 5566 335 336 337 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN 1795 6714 5879 4915 627 2904 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 5436 4331 5438 5439 902 404672 2071 2068 8732 8731 6829 5430 5431 5432 5440 5433 5441 2966 2965 5434 5435 5437 83640 2968 2967 1022 2963 2962 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing 200916 9045 51504 6233 1454 1453 6230 6232 6231 6234 6235 387338 6227 6229 26995 51335 6228 81554 55178 79922 130916 84881 285367 29960 7311 51001 3028 11340 23404 4839 54512 11224 5393 25873 23016 6188 140801 6187 51010 22868 6189 51013 118460 22894 56915 9349 6191 6193 6192 6194 3921 6122 6124 6123 6125 6130 6133 6132 6135 6134 2197 9188 6137 6136 51121 140032 4809 51602 6128 6129 10171 6201 79050 6142 84916 6203 10813 6202 23160 6141 6144 27042 55127 54555 6143 54433 84128 6146 51202 6147 8602 92856 65083 6139 11103 1736 6138 9277 25879 6152 9790 51096 6155 6154 55651 6210 55813 5822 6157 6156 27292 6159 56902 6158 2091 51065 115939 25926 6205 114049 6164 6204 6166 27340 6207 6165 27341 6206 10436 6209 57647 6168 6208 55623 6223 55226 6167 6222 88745 6169 55505 6224 10199 6160 9136 23521 57050 22984 6161 55272 51077 6218 10607 6217 11056 6175 4691 9724 6176 84135 134430 6171 51118 10885 6170 6173 79897 11102 54913 10799 6181 10557 10556 22803 10528 54931 9692 60528 55720 8780 54881 26168 81875 79159 51388 90459 8568 55759 705 79707 57418 23246 23481 26354 55131 81887 84946 55781 117246 83732 10969 27043 10438 51106 5394 10200 116832 23517 4736 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system 3827 8341 3848 8342 8970 8347 8370 8348 3273 128312 8345 8340 5329 5547 8968 3013 8338 2 255626 3021 85236 8349 710 3018 3017 54145 3818 3014 653604 2161 708 8331 8337 3015 8334 8335 474382 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 2155 2159 2621 2158 2147 8858 5624 632 5627 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism 1594 4036 51588 1591 7329 5641 6613 26119 120227 7421 2638 8029 AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy 7316 140735 1783 5116 200894 51143 11315 10013 7311 7314 8100 8655 6233 1781 1780 3320 3297 5071 1778 7334 1068 1080 7335 7415 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections 5928 5925 11035 3178 9360 7097 7096 8737 4869 4792 6654 5706 7534 8021 207 7529 1452 9978 83737 5978 8452 27243 23165 128866 9631 7175 25855 79643 51652 348995 9883 57122 5926 29082 55746 91782 23279 25978 79023 10762 4088 4089 92421 6396 129401 6093 4927 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 7341 1312 64135 2908 3551 23586 7329 1147 8517 5478 9636 7706 1175 160 161 163 2288 4690 3688 3718 5777 3437 3434 3433 861 476 477 3459 478 3460 53822 53826 53828 6233 7409 4790 480 3320 481 482 483 486 203068 695 5970 7316 7532 6667 7531 5336 6230 6232 6231 6234 64398 6235 63982 253832 6227 6229 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 7335 64601 79760 6480 10427 256435 27090 9868 9641 11282 8678 5479 5289 3661 7311 7314 29801 85437 81631 51304 3654 55107 5348 3656 5349 91662 6383 10082 6385 7113 59272 22863 5170 6382 143 58505 2697 51311 79668 821 3665 27072 3442 598 3441 3440 23367 114548 3439 2280 2589 51201 54956 100128731 55129 10971 10610 6850 221914 9672 3452 3451 2239 10800 3449 3448 10728 29110 3326 3446 3445 26762 3444 54960 3443 89122 10392 84818 3456 3454 55823 857 6607 5045 8487 1514 6185 6188 6187 6189 2262 23479 6184 23118 121601 2931 2810 3107 54106 3106 3105 6733 11253 746 54625 51114 6732 2817 5648 1603 5781 6632 7841 203859 6191 6193 6192 7284 6194 57101 26276 2342 51125 2339 51128 65082 84282 6628 7297 23339 6885 338440 3134 3133 9908 6634 6633 2719 6636 6635 10146 3339 3921 6637 7187 7189 84061 6773 6772 80143 55741 79833 3135 9475 11320 684 8829 7991 92359 51185 340061 4245 4124 3276 11218 10802 56965 201595 10484 10000 1901 3703 50628 2197 7082 23765 3716 140032 3838 1655 51284 1650 4247 4249 10454 50636 6441 57504 6201 23476 30849 6203 6202 5094 5931 7533 64127 26007 25834 567 83666 196527 84875 79844 1107 5589 57719 208 11311 3615 375790 7405 3614 3605 6210 1108 112744 4153 25929 25921 51065 7415 6205 6204 6207 6206 6209 6208 6223 6222 7555 54815 6224 257397 23193 10207 2530 7428 29108 6218 6217 57617 53615 834 5133 4780 79685 1915 1387 11123 10280 9111 29760 10284 64426 81030 2932 30011 23028 57459 2033 10362 51317 9219 9112 3717 8819 10465 3837 23186 3554 3570 973 974 3676 3066 3065 9817 51742 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors 11315 7341 4152 2033 28996 8648 10210 6294 10891 6045 25942 8554 1487 648 6015 10499 59348 4869 6612 51588 1912 3622 1387 7703 1616 1911 8204 7329 6613 80012 57332 10401 84733 10155 57591 9994 115426 7690 9612 1655 10521 8535 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions 55423 10326 2533 5777 7305 5747 140885 2185 8935 5781 961 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 23658 9337 25804 57472 11340 9125 23404 9775 54512 55802 5393 80349 29883 23016 5073 25904 51010 4850 167227 1981 51013 4848 4849 118460 22894 56915 26986 54464 55571 1975 1974 246175 1973 1977 9924 255967 51690 11157 79670 115024 9652 23318 10767 28960 219988 23644 1656 10605 196513 27257 80153 85456 23019 27258 6499 57819 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors 5519 51085 5518 5515 5516 5207 5528 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding 4913 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation 5436 6908 4331 5438 5439 902 129685 6872 404672 6874 2071 6873 138474 2068 6881 6880 5430 6883 5431 6882 5432 5440 8148 5433 5441 6884 2966 2965 51616 6875 6878 83860 5434 6877 54457 5435 5437 2959 2958 6879 2968 2957 2967 1022 2963 2962 2961 2960 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A 6448 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins 5295 9321 6711 2120 5290 50507 1026 4893 9846 7750 6654 5292 399687 3265 6777 2804 6776 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 51082 5928 10849 6908 57504 30834 2033 8370 5931 94239 9219 1107 9112 3013 221830 1108 23451 255626 5440 10514 5441 3021 54815 9533 3018 3017 54145 3014 5434 5435 5437 53615 8331 8337 8334 9014 8335 9015 9013 474382 10919 7913 8341 11335 8342 84172 8970 8347 8850 8348 128312 8345 2074 8467 8340 55766 8968 60 8338 9031 25885 85236 8349 3066 3065 653604 64425 2648 9188 7270 79101 2932 57459 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) 2997 2992 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 3768 59345 3773 2793 2792 2791 2790 2782 2788 2787 2786 2785 2784 2783 10681 51764 9568 3760 3761 2550 94235 3759 3772 55970 3762 3763 3765 54331 3766 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock 6907 8648 10891 96764 23054 10135 8454 6233 7321 1454 1020 1453 7316 5054 23291 5500 10498 1387 406 9861 56938 5682 79365 5683 5684 8945 28999 5685 25819 5686 5717 85441 5718 5719 7311 80205 7314 11047 6500 5499 10213 5713 5714 7979 6604 9575 5690 1386 5691 9572 5692 5501 5693 5694 6097 5695 5706 5707 6096 5708 5709 5687 5688 5689 2033 5700 5701 5702 5704 6256 5705 5465 10499 6095 26224 8553 150094 5187 8864 8863 23373 85457 7942 1628 1408 1407 4208 5936 2155 1460 1459 1457 79718 4209 64784 200186 10743 8841 4862 1374 9978 8204 23411 6720 5469 4297 551 9611 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 6652 231 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 1584 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors 3768 111 112 59345 113 114 115 3773 2793 2792 2771 2791 2790 2770 2782 2788 346562 2787 2786 196883 2785 2784 2773 2783 10681 51764 107 108 9568 109 3760 3761 2550 94235 2774 3759 3772 55970 3762 3763 3765 54331 3766 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation 808 5137 5153 5136 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor 2034 1387 2033 3091 25994 10370 2056 7422 405 768 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine 104 103 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen 2266 2244 2243 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation 7157 90809 3622 2033 5305 5608 5300 8396 79837 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways 80824 79849 6844 6616 6857 2023 567 999 4057 3043 57674 10015 4072 3326 4360 3040 6456 5045 5609 6416 1511 7097 6233 6843 5230 5987 2931 3320 1500 808 3837 79872 9900 2060 837 115361 112755 6455 7316 6457 4233 163351 6714 26276 2634 2633 1938 7322 2984 928 127833 1839 22987 3836 6804 6421 9146 51606 11151 867 7879 5868 4843 7296 8027 1499 7311 7314 10254 5594 5595 5604 5605 11045 9899 30011 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN 7316 8313 5687 5688 5689 5700 5701 5702 5704 5705 64750 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 6233 81847 5714 7979 8312 8658 5690 80351 5691 5692 5693 5694 5695 5706 5707 5708 5709 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD 1462 1634 2262 63827 633 221914 9672 1463 26229 10675 6383 10082 2239 6385 375790 2719 6382 3339 2817 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 6513 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function 5959 6017 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance 10714 5424 8370 57804 890 54433 8900 94239 23649 5422 1736 26277 1616 25913 5557 65057 5558 7013 3013 641 7014 55651 54386 546 5430 51750 5431 255626 5432 5440 5433 5441 3021 8607 55505 3018 3017 54145 3014 5434 1763 5435 5437 8331 8337 8334 8335 63922 79075 79991 80169 474382 100134934 6117 54921 5111 6119 5436 6118 5438 8341 8342 8970 8347 5439 1017 8348 128312 8345 8340 55766 8338 7486 23243 5982 5983 5537 55291 2237 85236 8349 5981 10856 55135 5984 3978 80119 5985 55164 8290 5425 7015 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling 7316 8835 9402 5295 5290 1027 3055 6850 208 2534 9306 84174 2887 6503 6777 2323 6776 867 5795 2322 7311 10019 7314 27 207 6233 2309 1445 10000 4893 9846 6654 3265 5781 3932 10018 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD 1738 593 594 1629 DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 2153 5624 5627 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 4802 3309 7184 811 22926 1649 8720 468 51360 4800 4801 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia 5687 5688 5689 8453 2033 5700 3091 5701 5702 2056 5704 5705 64344 7422 55662 54583 7428 6233 7321 768 7323 84962 2034 7316 6921 6923 9978 112399 112398 7322 1387 25994 10370 126374 405 9861 5682 5683 8994 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 79947 116150 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 7415 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 7321 6217 6175 6176 6171 6170 7323 6173 7316 6921 6181 6923 6230 6232 6231 6234 6235 7322 6227 6229 6228 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 6059 5693 5694 5695 5706 5707 7353 5708 22980 5709 9147 23008 55139 5687 55666 5688 5689 8453 5700 5701 5702 5704 5705 11224 25873 84164 10973 6188 140801 90850 6187 25898 6189 9349 6191 6193 6192 6194 9978 26046 3921 53918 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function 51129 1500 80332 1006 1495 1009 1499 3728 64403 8728 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling 5724 5777 3437 3434 3433 4938 103 3608 4940 9775 3459 3460 5335 8454 6233 4939 8662 7324 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 7316 10480 1964 6230 6232 6231 6234 8575 6895 6235 6227 6229 4869 6228 57506 5608 7334 3383 5518 8678 3661 3394 7311 7314 6500 7412 983 10437 5594 5595 5894 3665 3442 3441 3440 6774 3439 5300 2209 3452 3451 3449 3448 3305 5580 3446 3445 3444 8519 3443 3312 2176 3456 51447 3454 5045 11274 8021 6188 1958 6187 6189 1981 6622 2810 3107 3106 71 3105 3304 5781 6191 6193 6192 6194 2342 2339 25939 1974 7297 5371 1973 960 1977 3134 317649 3133 3921 6773 6772 3135 684 5495 2197 8651 3716 140032 3838 6672 3663 6201 2317 6203 6202 3664 3669 567 10612 1982 55128 378708 23165 51127 85363 9631 6210 7175 4599 9830 51065 6205 6204 6207 6206 6209 6208 6223 79097 6222 11074 6224 9470 6218 6217 834 23087 348995 9883 115361 57122 4600 4502 55223 55746 163351 23279 79023 10379 4684 3662 10762 8672 6396 7726 60 129401 3836 115362 4092 4927 4261 23650 10346 54920 4281 8638 199990 2175 55120 4734 2189 53840 5903 201626 91442 1660 9688 23225 2188 2187 3839 80233 201254 6041 55706 57697 6059 2178 3840 3841 23636 9972 11097 54739 23511 8086 3660 53371 8480 80128 79902 4904 3659 7341 81603 10410 8554 3430 9246 2316 64135 22926 3551 3717 23586 7329 25820 51191 9451 8877 2537 10964 117854 1147 23321 2289 8517 9636 7318 7157 3309 3429 10475 7706 5229 24138 3609 3837 5519 5525 6737 5515 80263 5292 5516 2635 9021 388646 3306 5610 815 816 817 818 2634 2633 402569 91543 1965 8894 1968 5770 5771 4690 3123 3122 3120 3458 3119 3118 3117 3115 3113 10581 10107 3127 3126 3125 5611 5696 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 6160 6189 6161 6233 6218 6217 6175 6176 6171 6170 6173 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 1938 6235 6227 1915 6229 6228 3921 6122 6124 6123 116832 6125 7311 6130 6133 6132 6135 2197 6134 6137 6136 140032 51121 4736 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal 54890 4255 121642 84164 221120 10973 51008 79068 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions 6441 6201 6203 6202 5094 7533 26007 3437 3434 3433 11035 6210 861 51065 6205 6204 6207 6206 6209 6208 6223 6222 3178 6224 9360 6233 29108 6218 6217 4790 834 5970 7316 7532 6667 7531 6230 6232 6231 6234 64398 6235 4088 6227 1915 4089 6229 4869 6228 57506 4792 11123 9868 9641 9111 5479 3661 7311 7314 3656 5170 5706 598 2033 114548 2280 10971 64135 29110 23586 7329 5478 7706 7534 857 10465 6188 6187 6189 7529 2810 3837 6191 6193 6192 6194 83737 3921 7187 7189 80143 684 340061 2197 140032 3838 51284 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog 409 7415 8454 6233 8405 5577 7316 156 6469 64750 9861 5682 50937 64399 5683 91653 5684 8945 5685 2619 5686 22873 25989 5717 339745 5718 5719 7311 7314 11047 6500 10213 5713 5714 8481 7979 5690 5691 5692 5693 5694 5566 5695 5706 79577 5707 2932 5708 5709 5687 5688 5689 5034 5700 5701 5702 5704 5705 57154 10956 84447 55733 51009 6868 6400 2262 3549 8650 7289 9742 23322 27248 55081 111 112 50846 113 114 132884 115 2121 23288 55764 2622 51684 1452 84455 79659 9978 374654 8100 83737 80199 51098 55811 408 79809 26160 196883 6608 11127 57728 5573 5575 5576 23432 2735 2778 27152 107 108 5567 109 5568 57539 54903 2737 5727 2736 8452 85455 57758 147111 CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects 3708 5152 5153 5136 10846 27345 10242 5138 50940 27094 3778 3779 10335 8654 5593 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection 3162 114548 718 3326 953 4907 957 7295 4791 1511 4210 9051 29108 4790 10910 10628 5027 834 5025 3552 3553 719 3606 79792 5970 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly 5699 5687 5688 5689 5700 5701 5702 5704 5705 9861 5682 5683 5684 5685 5686 5717 143471 5718 389362 5719 56984 51371 80227 11047 10213 5710 10197 5713 122706 5714 5711 7979 8624 5715 5716 5690 84262 5691 5692 9491 23198 5693 5694 5695 5706 5707 5721 5696 5708 5720 5709 5698 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors 8578 811 10808 338 348 2512 3043 4035 3240 5052 2495 8542 3512 259 10525 3263 3250 3040 213 8685 1284 4481 1282 286133 7184 1281 117156 3146 81035 78989 6288 9332 55576 6280 1278 1277 3320 948 23166 284297 922 335 5648 6678 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 5929 84661 11091 9070 8085 S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase 5928 10714 5424 57804 902 5925 23649 5422 993 994 54107 208 5557 5558 595 4149 8454 6233 7321 25906 11065 8697 7324 6502 10393 29945 29882 996 5934 1022 51343 51529 8881 64682 6117 7316 6119 27338 119504 6118 91750 286826 246184 132660 55957 51434 51433 157570 114799 9861 5982 5682 5983 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 4176 2237 5718 64785 5719 8318 9837 7311 84296 7314 4171 11047 6500 51659 10213 5713 5714 7979 1026 91768 5690 5691 5692 5984 3978 990 5985 5693 51053 5694 5000 5695 5001 7465 23595 5706 23594 5707 81620 2932 4998 5708 4999 5709 1875 5687 5688 4331 5689 5700 898 5701 5702 5704 5705 9134 890 8900 1874 1869 207 1763 7027 23047 113130 23244 23063 7029 5111 1019 1017 9978 1027 9126 5753 10735 10274 8243 1163 5885 5981 10000 56655 5425 5426 5427 4609 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX 581 637 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling 1442 8945 5617 8454 9978 6500 3717 2690 5618 6777 5781 2689 6776 2688 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling 146850 5294 5295 23533 5296 79109 253260 5290 5291 5293 208 2534 55615 8503 1326 940 941 942 64223 117145 207 2475 10000 57761 5170 9020 3932 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events 5928 91750 1063 2305 286826 132660 4605 2033 55957 9133 9088 993 5347 995 7465 891 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism 10841 138199 131669 3034 3176 3067 26 144193 57571 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants 3815 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases 9100 10454 317772 3091 85235 409 23326 993 6881 221613 8295 9986 92815 377630 8969 8607 57599 23032 440689 6233 6314 27430 6502 8331 8337 3416 8334 8335 154 9101 7316 9738 4194 7186 8341 8342 8347 79594 8348 8345 6478 4193 4086 8340 8737 4087 4088 4089 4792 8338 9099 64750 4092 9861 5682 5683 5684 5685 5686 9868 5717 85236 8678 5718 27005 5719 8349 7311 51616 330 7314 11047 10213 7046 5713 5714 7979 7375 5690 5691 1540 5692 5693 329 5694 64426 5695 25862 100287513 5706 63891 100287238 5707 100287478 7353 401447 5708 9736 5709 645836 728386 7417 51651 8313 5687 7419 100287178 5688 29761 5689 57646 9804 5700 84101 5701 100287327 100287205 5702 100287441 991 5704 645402 5705 100288520 890 8724 392188 8900 219333 100287144 10868 367 10869 23770 91833 84196 64135 9960 8078 728419 23586 3013 100287404 100287364 55031 23358 83844 57695 63967 84132 8517 10600 255626 7157 9097 84749 11274 3018 3017 7874 8975 81847 1643 90865 8658 8312 9958 80351 10474 8970 7416 128312 8239 5728 6885 5423 408 55288 2625 9146 7189 79589 55611 10254 4303 9817 2648 93624 1080 4609 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS 10071 94025 140453 143662 4588 118430 4589 56667 283463 56913 394263 4582 4583 4584 4585 4586 200958 727897 29071 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events 208 5140 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis 64241 64240 5824 215 5825 26154 21 10349 10347 20 9619 335 10350 64137 23461 23460 8504 225 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation 5777 3708 3709 5295 81 5296 197 5290 5291 3710 7273 160851 1609 10451 1608 747 7422 1607 7040 5216 1606 5579 2151 1950 7410 5590 7222 7225 221955 1191 7409 9002 5581 6810 6814 57113 5583 10672 5660 5336 5054 139189 9162 4067 5588 10235 10125 2811 135228 7277 14 7057 5906 5594 5595 6654 5170 5894 388 27154 391 6850 346562 2534 5580 2773 5155 2 150 152 5267 350 94121 5578 8407 51097 23052 7534 9749 54495 813 7114 3671 66005 7123 22915 29106 83706 207 10184 51571 3699 54863 7044 10490 1432 29789 51368 51266 5552 7076 22927 2277 10916 6915 7078 7873 5099 1521 2768 6414 5781 308 3700 5341 3959 5340 54676 3937 1893 259215 78991 9948 6694 7424 7423 334 2335 5919 55664 374354 10447 87 408 3479 88 64805 335 3932 5294 1675 1 409 7018 2771 2770 5582 5004 5005 351 808 948 1445 3082 5908 6813 23533 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 5265 80739 51206 10630 213 5196 8503 12 5874 9630 94235 998 226 55970 54331 146850 2767 11069 7450 59345 7043 7042 2769 5473 2782 2316 2776 10487 10681 5478 3309 5175 2153 2149 2147 710 2266 7414 3690 2243 2162 11343 2157 3920 5627 2244 2812 3827 2815 2814 5747 5345 2621 6714 3273 5880 2207 7094 9564 10257 51706 5321 1398 928 139322 5879 967 5770 387 3481 5768 6403 3674 8527 8525 8526 6464 6647 54518 10411 27040 7066 4352 5028 151 1072 26090 57406 6678 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) 6559 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g 79087 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) 6774 8370 79813 890 8900 94239 3013 6197 6196 6195 255626 3576 3021 3018 3017 54145 3725 6233 3014 7321 4790 25906 11065 8697 7324 8331 10393 8337 29945 8334 29882 8335 3552 996 27287 51343 51529 5598 8881 64682 474382 5970 7316 27338 119504 10919 1051 1019 1032 246184 8341 1031 1029 8342 3569 8970 8347 51434 1017 8348 51433 128312 8345 1027 8340 55766 3490 8968 8338 1021 2353 85236 1030 8349 7311 7314 1026 653604 5594 5595 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders 2874 808 6907 79718 814 5566 9612 25942 9611 8841 3065 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines 29110 340061 6778 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation 2247 2254 8074 2249 2591 2246 8823 8817 26281 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 6888 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins 3082 4233 3688 64759 84951 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 7316 5295 1950 2549 5335 6464 1956 7311 5290 7314 6233 3320 4893 6654 3265 11140 867 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane 55300 6305 22908 5297 8898 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling 6774 7341 378708 103 3608 9246 3551 25820 7329 3305 51191 8877 1147 3312 8517 2176 9636 7157 7706 6622 3609 5519 5525 5515 5516 3304 5610 3306 8575 6895 4869 57506 1965 8894 5608 1968 5771 4690 54920 6772 199990 2175 5518 55120 2189 1660 91442 2188 2187 983 80233 201254 57697 2178 5611 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function 1500 1495 1499 80149 3728 6663 28513 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling 596 59345 5295 5296 5290 2771 2099 3480 2770 2782 346562 208 2773 595 10681 8877 7514 2002 6801 340481 857 1950 4846 5590 1956 207 3320 808 2309 1903 127933 255324 5747 374 6714 2069 2793 2792 1027 685 2791 2790 2100 55625 858 2788 2787 2786 2785 2784 6722 2783 1839 51764 2353 7039 8503 94235 3276 4313 4314 5594 4316 5595 10000 55970 4318 4893 5170 3265 54331 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL 9350 4838 7044 10637 55997 6998 199699 130399 91 92 93 6997 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG 4552 4548 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing 6431 9984 51585 10250 22794 3188 57187 27336 3184 51362 5093 199746 5094 7919 3192 51593 84324 84248 3191 22916 84844 6427 84321 55660 3190 6426 9939 6429 10212 6428 4686 9877 8175 51213 10189 84271 6434 8189 65109 80145 26097 8563 8683 5430 9775 5431 9295 23350 10569 5432 10921 11338 5433 55110 79228 4116 7307 10946 3178 4670 3187 10914 6233 5725 83443 3183 2963 2962 7316 5436 51639 5438 5439 79869 5500 10291 51692 8241 10285 7311 7314 27316 5499 22803 1660 1665 84991 2521 81608 10898 55339 4904 22826 5930 22827 11325 55749 23451 5440 5441 5434 5435 23283 5437 53981 6632 10772 1479 29894 64852 1478 1477 6628 57794 8106 6634 6633 10992 58517 6636 10262 6635 6637 10523 64895 10236 10978 5511 5514 23524 3181 3185 9584 6631 10929 6625 6627 6626 6629 135295 220988 23450 6638 10915 9879 1655 11051 9785 6430 6432 10181 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport 9123 6566 9194 133418 23539 682 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL 5175 5777 5518 338 2268 5321 5519 1432 7804 5525 5515 5526 5516 5527 5528 5529 5781 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing 6431 5356 10250 22794 3188 3184 51362 199746 9716 7919 3192 3191 6427 3190 6426 9939 8896 6429 6428 10189 6434 10084 65109 8683 8449 9775 23350 9295 9343 10569 10921 56259 11338 55110 4116 7307 10946 3178 4670 3187 10907 9360 5725 27339 83443 3183 85437 3312 6632 11066 10772 11193 24144 8899 55100 143884 51428 10081 23398 3550 9092 6628 22985 55234 55599 8559 57794 58509 6936 59286 79576 6634 6633 58517 51690 6636 51691 10262 6635 11157 8233 6637 151903 10713 10236 5511 55702 5411 23524 153527 60625 57703 84811 55954 11017 9584 6631 154007 10929 6625 6626 135295 27258 84950 9128 9129 26017 23020 10915 85313 7737 63932 9130 9879 4236 9410 79706 57819 84081 1655 25949 9416 10181 79171 4809 91603 1659 23658 55094 27336 5093 79165 5094 26121 51593 163859 25804 22916 84844 79753 55660 7536 51747 23759 79622 51634 51759 4686 8175 51503 5430 5431 55696 5432 5433 56949 5546 2963 2962 5436 51639 10179 5438 5439 51645 10291 10283 8241 10286 10285 27316 1660 1665 10284 84991 2521 4904 22826 22827 54883 11325 55749 23451 10450 5440 5441 10465 53938 22938 5434 5435 5437 24148 51340 57461 27238 51729 10992 10523 3181 3185 988 6627 6629 220988 23450 6638 10594 23517 9785 6430 6432 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase 1312 4128 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 10319 8082 54221 137868 3914 3915 3918 1821 375790 3911 3912 3339 1838 1837 3908 8910 3913 3910 6641 6640 1756 3909 6645 1605 7402 284217 6443 6442 6445 6444 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis 51144 6716 3972 3293 1586 79644 3284 5443 3283 6715 1081 DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells 3913 10319 3910 1950 3914 3915 2335 3918 3909 7448 284217 3911 3912 3908 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants 2322 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 5423 79661 4968 7515 11284 252969 3980 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen 2812 7450 11093 2815 2814 2811 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate 8566 55163 316 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1544 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions 5742 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 2247 2251 2248 4893 2255 2252 6654 27006 2254 8074 2249 3265 2246 8823 8817 26281 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade 10454 64127 7100 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 51231 246330 2002 1849 5599 9097 1848 9252 3146 1846 6285 1326 1845 6288 5609 11274 466 6283 6416 9683 4791 5601 9684 257397 7867 8454 4793 5602 28512 5606 57161 3725 57162 6233 177 23118 121457 351 4790 28511 80216 5519 1432 5515 5516 5600 5528 5598 5970 7316 7186 23291 841 6885 8767 4792 5608 7334 7335 7189 2353 8945 81793 5518 51295 7311 7314 6500 3654 3656 5594 1386 5595 5604 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling 145957 3084 10718 5295 2069 1839 5290 685 9542 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 4683 8370 165918 7158 2547 51588 22976 255626 10111 4361 3018 3017 54145 472 3014 5591 672 29086 9025 51720 8924 84142 9577 79184 8341 8342 8970 8347 8348 128312 8345 8340 580 7520 9656 51567 79840 7334 55775 10524 7336 55183 27343 7518 64421 27434 7468 85236 8349 3981 8290 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 7879 80824 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 51082 6908 5451 10302 55290 55814 5440 5441 6621 6619 7702 6618 6617 9533 51728 27297 661 10623 171568 84265 5434 55703 5435 5437 55718 11128 10622 10621 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 1738 593 594 1629 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism 4552 326625 166785 4594 27249 25974 4548 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) 153201 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins 286053 23137 7341 165918 8554 5893 23165 6612 7508 51588 641 7329 9631 6613 7175 6996 8021 348995 672 9883 57122 8535 8924 6117 55746 51564 1029 6045 23279 79023 648 1069 5371 6015 10762 6396 9126 1912 142 7703 1911 9656 129401 10735 80012 7486 4927 57332 84733 7518 10274 8243 5885 5903 9688 23225 197370 493861 55706 23636 9972 11097 79677 23511 8086 56160 53371 54780 8480 79902 6672 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease 5928 5356 80824 79849 9968 3188 3184 9969 902 9716 3192 5925 3191 3190 8896 4057 4061 6238 4072 10084 9789 8449 23350 9343 56259 22924 80349 10945 10946 10949 10907 9360 7097 10914 7096 80306 1191 9382 27339 4939 83443 920 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 3312 7514 7534 8021 1981 207 5230 7529 1994 1432 26986 54464 3304 111 112 113 114 115 1452 9978 83737 196883 5573 5575 5576 2778 107 108 5567 109 5568 6122 6124 6123 6125 6886 6130 6133 6132 6135 8452 6134 6137 6136 6128 6129 6142 6141 718 6144 129685 6872 22916 6143 6874 6873 23327 6146 2547 6147 27243 55048 6139 23165 4686 6138 128866 89853 10015 6152 6749 6155 9631 6154 7175 6157 6881 7525 6156 6880 5430 6159 6158 6883 5431 6882 5432 6164 6166 8148 5433 6165 6884 7852 6168 6917 6167 79643 1104 6169 51652 51497 6160 11198 6875 6161 6878 83860 8812 6877 51534 6175 2959 6176 2958 6879 6171 8815 6170 2957 6173 348995 9883 9525 57122 2963 2962 2961 1234 2960 29082 29959 5436 55746 6921 5438 6181 6924 137492 5439 6923 27183 91782 23279 25978 79023 51271 7469 138474 10762 4088 8178 4089 92421 6396 8732 142 7520 129401 8731 112950 51160 6829 3836 4927 3159 7518 155382 6827 9397 93343 9150 7251 5905 79720 2237 1025 5901 5902 51616 5903 3981 9688 23225 25920 54457 51224 7936 55706 3978 23636 9972 11097 23511 8086 53371 8480 79902 51510 904 4904 905 4836 1312 9246 64135 3551 23586 25820 51191 1147 8517 9636 7318 3309 7706 6456 1175 160 161 2147 163 1213 1211 2678 5627 2687 5610 5613 953 957 116832 22937 3688 5611 3843 10965 2926 3718 6616 5777 5295 3437 3434 3433 11267 51028 84313 861 476 7040 477 200916 478 53822 53826 219541 53828 4790 480 481 482 483 486 5970 3162 3569 6667 5336 6230 6232 6231 6234 64398 6235 63982 253832 6227 6229 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 7335 64601 79760 6480 10427 256435 27090 9868 9641 11282 8678 5289 3661 29801 85437 81631 51304 3654 55107 5348 3656 5349 91662 6383 10082 6385 7113 59272 22863 5170 6382 143 58505 2697 51311 79668 821 3665 27072 3442 3441 3440 23367 114548 3439 2280 2589 23389 51201 54956 57105 100128731 2268 55129 917 3055 10971 10610 6850 221914 136 9672 2209 3452 346562 3451 1800 2781 10800 2239 3449 2534 3448 2214 2212 29110 3326 2773 3446 3445 26762 3444 54960 3443 89122 10392 84818 3456 3454 55823 857 6607 8487 6185 6188 6187 4793 6189 2262 23479 6184 23118 121601 2931 2810 3107 54106 3106 3105 6733 11253 746 54625 51114 6732 2817 5648 1603 5781 6632 10053 7841 9349 203859 6191 6193 6192 7284 6194 57101 26276 51125 162 51128 164 65082 84282 6628 7297 23339 6885 338440 3134 3133 9685 9908 6634 6633 2719 8907 6636 6635 8905 10146 5878 3921 6637 7187 7189 84061 130340 6773 6772 4907 80143 55741 1174 79833 3135 11320 8829 7991 92359 340061 4245 4124 3276 11218 10802 56965 201595 10484 10000 3703 50628 2197 7082 23765 3716 140032 3838 1655 51284 1650 4247 4249 10454 50636 6441 6201 30849 6203 6202 7533 64127 26007 25834 567 2771 83666 196527 7474 84875 2770 79844 5589 57719 8324 208 11311 3615 375790 7405 3614 3605 6210 112744 4153 25929 25921 51065 7415 6205 6204 6207 6206 6209 6208 6223 6222 7555 4791 6224 257397 4210 23193 10207 2530 7428 9051 29108 6218 6217 57617 808 10910 10628 5027 834 112755 4233 4780 2793 2792 1938 2791 2790 2788 1915 2787 2786 7317 2785 2784 10533 2783 51764 94235 998 55970 23028 55236 54331 59345 10362 51317 2782 3043 3717 57674 10681 3725 22938 23352 23186 1794 9844 2984 63916 1398 1793 1839 5879 6421 9146 51606 867 11151 7879 4843 3181 3185 5062 2194 6627 9817 9039 8065 3586 79876 9785 6430 6432 6431 10250 51362 199746 6427 6426 6429 6428 11035 197259 10189 8683 9775 9295 10921 11338 79651 10769 7307 3178 9332 4627 4670 3187 5725 1500 79872 2060 4651 4644 4620 4641 7099 929 23643 253260 8737 57521 7322 4869 4067 4792 2475 5594 5595 5604 5605 6654 79792 5034 79109 1616 55615 140801 64223 5987 5025 55588 3552 3553 719 3606 81857 1974 5371 1973 1977 8106 7098 5868 5978 51121 317772 85235 25855 221613 92815 8969 23521 440689 5926 292 293 8976 6093 55763 8729 27316 5499 7353 55666 7341 2908 7329 9412 10787 5478 1460 1459 1457 4650 9441 291 57551 51586 5747 6714 10951 2288 27035 4690 7296 7295 10134 55845 10254 8936 400569 147179 3708 51143 3709 3710 55090 10006 10458 10451 23097 3459 3460 9045 7410 5335 1956 10109 8655 6233 7409 1781 3320 1778 124056 203068 3183 695 10552 5577 140735 7316 3071 7431 7532 8974 7531 79869 283208 5500 10093 10092 5033 64174 10095 10094 10097 6804 10096 4751 8945 10768 7454 7456 5479 7311 7314 6500 5501 5566 6837 598 6844 6857 2023 644150 999 26999 10728 6868 11224 940 5045 25873 1514 10152 1511 71 837 10163 5824 1479 1478 1477 2342 2339 57794 5869 317649 127833 1052 1855 11100 10811 10262 54797 90701 10810 3339 10236 5593 1857 4131 1856 23524 115004 57703 9475 684 8027 689 51185 1901 4318 23020 9862 85313 11045 9879 335 9410 9899 11051 9416 3932 10181 51585 6908 6907 57504 23476 23478 5093 5094 51593 5931 54623 404672 84844 1982 1993 1524 1780 1107 8175 8189 1535 51503 1108 23601 9076 25 55690 55696 1783 11168 712 54815 716 721 722 725 6843 4666 4691 23191 53615 56949 9900 375 8331 5546 8337 8334 8335 115361 1022 10332 51517 10333 7301 6455 84246 5119 10313 5133 54344 6457 51639 8341 23168 8342 163351 8347 8348 8345 51645 8340 79685 8672 9532 1024 1387 60 8338 10291 10294 9443 51692 11123 2923 9442 10280 10283 25777 9440 8241 51234 10286 10285 85236 9111 8349 29760 10155 9439 1660 60559 1654 3839 1665 10284 84991 3840 3841 2521 64426 81030 81608 79577 2932 10898 30011 55339 57459 123169 10421 811 4331 2033 285755 8370 51003 2146 22826 22827 6993 3480 9219 54883 9477 9112 3013 11325 90390 55749 4360 8819 23451 64225 10025 3040 54431 255626 10450 5440 2002 5599 5441 5609 10461 10465 6416 11314 2966 892 2965 3018 3017 54463 3069 5434 53938 5435 28972 5437 23283 3837 79718 440400 24148 7448 2968 9646 2967 53981 51340 8841 57461 10001 27238 29894 815 8970 2621 816 51726 128312 51729 817 818 2634 2633 402569 2071 80273 30835 2068 8726 8968 926 928 10992 22987 10525 10527 945 29079 10523 10978 3554 2874 3570 973 5469 974 3676 9282 988 3066 3065 6629 653604 220988 51742 23450 8813 6638 8818 10594 91937 9612 550 9611 4736 23512 558 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses 7316 6441 114548 5094 2280 26007 3437 3434 3433 83737 11035 64135 57506 4792 23586 29110 861 11123 7187 7189 5478 80143 7706 9868 9641 684 9111 10465 5479 3661 7311 340061 7314 9360 6233 29108 4790 3656 3837 834 3838 51284 5970 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA 55746 23279 22916 79023 10762 23165 1977 6396 4686 10189 129401 9631 7175 4927 10482 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 7884 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate 23169 7358 11046 7360 80146 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions 4691 4067 7251 9685 5045 8729 10945 4904 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 1462 126792 1634 2262 63827 633 221914 9672 1463 10675 6383 10082 2239 6385 375790 2719 6382 3339 2817 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT 1312 220074 4128 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer 7046 7040 7048 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy 51143 11315 30849 27243 55048 1780 123 128866 89853 7405 7415 1783 11345 8408 79643 51652 8655 472 6233 1781 3320 8649 1778 7323 29082 7316 140735 10133 10542 11337 10013 137492 91782 389541 25978 28956 51271 57521 7322 6009 1915 92421 10533 10226 51160 7332 7334 7335 155382 93343 5116 7248 7251 9868 7249 79720 8678 5289 55004 7311 7314 81631 8897 53632 2475 55062 3297 9140 51001 22863 58528 10452 9474 1068 84557 100188893 139341 401505 56993 7417 7419 79065 200894 54543 9804 9927 51422 3043 5071 29110 3326 5562 5564 3312 4077 5830 8878 84749 65018 1460 5571 64223 1459 1457 5563 5565 3920 55669 64419 64121 2034 7416 8100 10670 153129 10325 2670 115201 55054 89849 285973 56270 55626 9776 23710 84971 440738 9821 6035 60673 11152 84938 83734 64422 23192 26100 1080 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins 503614 245911 117285 1235 1673 245936 140850 245937 1672 245938 417 245939 245927 245928 245929 81623 613210 613211 245930 728358 245932 245934 644414 5646 503841 641517 504180 613209 400830 729230 1671 1670 245940 7097 7096 55894 5645 1668 100133267 140881 920 1669 245913 503618 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 4686 6634 134353 6636 6635 22916 25888 6637 84967 6628 7884 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import 100287932 1678 84269 506 51025 54543 131474 9804 134266 131118 79145 388753 10245 1537 197257 29928 51142 26519 26520 3421 516 10440 29090 1431 5009 10063 6901 291 10651 293 9512 54927 23203 3329 7416 90639 25813 80273 10165 50 8604 4714 9868 3313 617 4580 27235 2671 26515 26517 150274 2395 51287 10452 100272147 10531 400916 26521 100188893 10469 498 56942 401505 92609 56993 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 9554 9342 2801 2890 4905 10945 9332 4627 6280 9382 2060 920 4644 6810 6814 4641 1121 6712 5052 1075 93661 7039 55860 51164 84516 53632 10671 10808 338 81846 3630 5564 3312 8685 4481 286133 7184 117156 2799 7534 81035 78989 55576 5571 207 1777 7529 11154 8906 9179 134829 157807 11127 286 5867 5868 57134 4121 10905 5286 8578 27243 55048 22878 22879 128866 89853 79090 221960 79890 84958 57589 2665 80006 2664 57465 23163 51762 23682 83874 10890 11345 8408 729873 79643 10260 6764 51652 9230 9909 84315 51256 160518 27095 163259 126432 51534 9363 81876 26130 3257 6305 27342 79958 9135 201627 338382 9525 125058 163486 382 54662 201475 51399 9267 55357 29082 9265 1122 9266 57533 8675 7109 27128 117177 11337 22796 250 6399 143187 5861 137492 11021 347517 84342 51560 27183 91949 79735 91782 9950 23265 25782 57706 25839 5872 25978 27314 5873 10228 51272 51271 378 11031 126003 60412 83548 58485 27333 57511 54536 23258 79961 9527 92421 9609 51693 10466 6396 26000 116442 8976 26088 1362 60684 10640 10226 8542 122553 3512 55738 11336 51160 23011 10981 259 5866 3263 149371 3250 84079 9827 374403 155382 22930 22931 213 10052 22898 57165 54453 375519 93343 57369 23062 55763 55667 7251 2702 27147 2701 8729 79720 2700 83696 5874 127534 8301 54734 2709 55770 2707 51622 2703 83452 219770 4943 259173 125111 89781 10804 23637 81025 9610 84694 64786 11015 3949 414918 8766 51112 128637 51510 23208 9185 9856 115548 1861 9183 8674 27348 23149 85439 9892 10113 22905 3267 10652 85021 3998 29988 950 143425 22848 4738 6572 286749 90019 55707 29978 29979 84251 51552 6456 1175 2153 160 161 163 26052 9570 1785 1213 1211 1759 6811 56894 22836 2157 6709 4646 57679 6711 8398 2590 636 23299 5321 5050 5049 2017 54874 10254 8533 64708 10987 51138 2706 2705 10980 1080 51143 50813 26119 23433 10920 11267 51028 84313 185 26958 10139 60592 55850 84316 400 51014 8677 1950 339122 23423 372 1956 10109 51542 7110 381 662 8655 6869 10244 23647 6233 79571 1781 9276 3320 9712 90196 11316 6453 122830 1778 60561 60560 22818 154 6293 2800 1314 54732 1453 51226 738 10552 53407 22820 55275 140735 7316 51594 10133 11014 156 7532 1129 7531 8773 10093 8871 4035 10092 4036 10094 10540 10097 4218 9871 10096 23048 9632 5048 8867 1284 10427 1282 1281 288 7311 7314 81631 58513 1294 29924 10121 23166 284297 922 11258 2697 6844 4074 5864 6857 2589 917 10971 51422 23396 84364 51209 23256 3146 6288 966 9322 1604 2810 5563 5565 9318 5648 255324 7037 7164 9026 10053 8775 388552 3482 7163 6272 10618 286451 8546 6643 157 162 51128 164 27131 81567 55330 2512 54885 152503 408 5869 9829 8673 127833 9685 9341 26258 2495 2647 8907 10717 8905 5878 84062 2804 51429 130340 9698 1176 1856 23431 64746 1174 2580 23557 8027 25977 1522 4124 10802 26286 10484 10000 9367 7082 335 50618 2803 6517 1212 7533 409 375056 348 112574 7018 23216 4253 9847 8322 57186 7474 11070 9882 1780 3240 273 1523 208 274 11311 11252 29763 79058 57148 29993 1601 8218 2873 1783 4952 9321 351 808 948 375 377 10342 6455 6457 374 6836 5265 8774 23243 22870 2348 10175 10972 5537 7248 9117 11196 7249 64689 9585 23046 55291 24137 254263 1062 25956 55014 64837 81562 1639 26153 63908 8615 149111 9919 147700 90411 55605 10282 26984 79748 89866 10960 22920 55614 146909 22872 55582 23303 30011 29127 6708 10112 9371 811 6710 221458 9493 547 829 55083 3043 81930 84643 830 4122 832 3796 3797 113220 3831 3798 3040 3832 3799 3833 3834 5870 3835 90990 285643 57731 23095 10749 10959 3092 287 124602 56992 51332 89953 9648 11004 64147 1315 2069 685 1839 10525 5879 3575 9146 867 7879 4012 5898 6845 1278 1277 915 551 554 6678 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression 6929 2033 6667 6256 4613 4343 4088 192669 4089 23112 4617 27327 26523 4618 27161 6938 192670 57690 5914 6925 4654 4656 83855 3070 7049 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism 51727 3251 151531 55270 51733 132 93034 3615 83549 1807 3614 1806 26289 353 2766 4830 4831 158 4832 159 1635 4833 1633 30833 270 7498 79077 271 272 54963 64902 10591 4860 50484 2987 11164 377841 1841 22978 56953 5471 1716 8833 122481 1723 131870 25939 203 204 158067 205 790 471 953 5198 954 9615 8226 122622 955 7378 84618 956 4907 957 7296 7372 51292 7371 7298 56985 25961 100 7295 56474 1890 1503 10606 2618 978 10201 161823 221264 7084 7083 2745 6241 6240 57089 9583 102157402 3704 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 55247 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling 7316 5687 5688 5689 5700 5701 5702 5704 5705 5971 23291 1147 9861 5682 5683 5684 8945 5685 5686 5717 5718 4791 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 9039 5693 5694 5695 5706 9040 9020 5707 5708 5709 5970 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres 10714 5424 57804 890 54433 8900 23649 5422 1736 26277 25913 5557 65057 5558 7013 641 7014 55651 54386 51750 8607 55505 1763 63922 79075 79991 80169 100134934 6117 54921 5111 6119 6118 1017 7486 23243 5982 5983 5537 55291 2237 5981 10856 55135 5984 3978 80119 5985 55164 5425 7015 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency 7172 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation 933 4067 973 5777 974 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer 7157 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 5133 29126 6185 7991 100128731 6184 142678 201595 3703 746 3716 80380 58505 1603 1650 10331 84061 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation 2247 3730 10755 7049 2254 8074 2249 2246 2251 26281 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 2584 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers 808 6543 6546 6547 80024 57419 9187 25769 6717 283652 123041 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis 5111 6119 10714 6118 5424 57804 23649 5422 26277 5557 25913 5558 65057 7013 641 7014 54386 7486 5982 5983 2237 5981 1763 3978 5984 5985 63922 5425 79075 79991 80169 100134934 6117 54921 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH 5111 7316 6119 83932 55666 6118 7311 25898 7314 6233 5981 5984 5985 7353 5982 7415 5429 5983 6117 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion 9397 7316 93343 7251 5045 79720 137492 7311 7314 51271 6233 55048 89853 51160 155382 5478 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 8547 2219 5648 2220 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling 521 9556 10476 522 506 509 84833 539 513 4508 514 4509 515 516 517 518 9551 498 27109 10632 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade 10454 64127 51231 1849 1848 1846 1845 4791 257397 8454 6233 351 4790 5970 7316 7099 929 7186 121260 353376 23643 148022 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 51311 3665 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 57161 3725 57162 177 23118 121457 28511 80216 54106 5519 1432 5515 5516 5600 5528 5598 6885 7189 51295 51284 80231 3663 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing 4790 834 4791 3552 1511 3553 3606 5970 79792 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions 2247 5578 3693 3371 3685 3655 3690 8573 7057 87 9672 3691 6383 6385 7448 3688 6382 3673 7040 51399 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane 9662 8655 7840 80776 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 23322 9814 261734 9738 117177 11190 51134 9793 7532 51259 7531 54806 10383 4735 10382 23332 115106 79441 84902 95681 1069 79598 5347 22919 4867 54801 10142 9657 7846 91147 9702 27077 10540 85302 5108 4218 11116 347240 4751 5048 55142 22832 22897 57787 57545 54930 5116 79959 80184 54903 5518 26005 93323 7277 79600 26123 23354 22981 132320 8481 80254 8766 983 146057 121441 55755 54820 10806 10121 79867 5566 55835 55559 8636 11258 84131 4957 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 3708 5921 3709 5295 5296 2185 5290 5291 653361 3710 10006 208 1536 1535 10458 10451 2321 7422 3728 5228 9047 5579 6461 3791 7410 5335 5590 25759 5603 6300 7409 1500 808 3320 23191 2324 1003 3071 253260 6093 10768 1499 14 998 2475 5566 5170 8440 5058 5063 79109 26999 2534 8828 5580 55615 8877 9261 10787 3315 5578 1495 857 3685 4846 7867 10152 64223 3690 117145 207 1432 57761 2277 5600 10163 5747 7424 7423 5829 9564 9844 63916 1398 1793 5879 10810 387 4690 5567 5568 9475 5062 8829 4688 55845 4689 10000 4893 8936 3265 558 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis 293 7040 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters 9498 8671 23382 9497 83697 6522 57835 6508 57282 6521 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) 142680 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport 6580 9429 5243 6582 6581 SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS 9791 81490 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation 5058 9402 3937 5336 6850 4067 5879 10451 4214 2353 5599 7410 5609 5062 5335 6416 5601 5602 3725 7409 5594 5595 4893 6654 3265 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins 55746 7341 10210 23279 79023 10762 23165 6396 51588 129401 7329 9631 6613 7175 4927 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling 7316 10818 2248 2255 2252 27006 10253 8569 867 2247 5518 7311 7314 2251 6233 673 5594 5595 5515 2254 8074 5516 2249 2246 8823 5781 8817 26281 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins 840 118 28988 4137 2934 7431 836 6709 839 841 2620 5339 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases 7316 378884 2548 8908 2632 7311 7314 2542 92579 6233 2998 2997 2992 5507 7957 2538 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production 111 112 59345 113 114 115 3569 5613 2793 2792 2771 2791 2790 2770 136 2782 2788 346562 2787 2781 2786 196883 2785 2784 5573 2773 2783 5575 10681 51764 5576 2778 107 108 5567 109 5568 94235 55970 5566 5577 54331 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse 25791 9475 79784 4627 4637 4067 2534 10398 103910 7525 6093 4628 4629 387 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 7157 843 834 8738 55367 835 8626 317 839 58484 472 7161 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 10576 10575 908 60 6950 7203 10693 22948 10574 10694 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d 2683 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 5977 86 6601 6603 6602 6605 6604 6760 60 9274 605 9275 64919 8289 55274 6597 6599 6598 53335 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling 4851 84441 9794 2033 3516 55534 8850 182 22938 3280 1387 2648 10046 864 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling 127124 23545 537 51382 79689 533 7018 534 535 7036 3077 50617 51606 245972 245973 55240 155066 9114 9550 8992 90423 10312 523 57192 525 526 9296 527 7037 528 529 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation 3084 88 815 6714 816 4900 4747 817 818 2891 1742 808 2906 2905 2902 1741 1740 2890 2904 57554 1739 2903 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E 7316 7311 7314 6233 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 2673 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events 30849 91782 5925 25978 221914 27243 9672 92421 2239 128866 375790 7405 2719 26762 3339 7415 5045 1514 79643 8678 8829 5289 51652 85437 2262 81631 23479 7428 6383 10082 6385 7113 59272 6382 2817 1655 29082 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors 3417 1528 26119 151056 92014 56910 64802 51004 10135 119391 51248 349565 6948 6947 80308 3320 7804 5950 5948 10840 154807 338328 10588 65220 1109 4035 5947 4036 6697 54884 5646 6513 6515 4338 84274 55739 10560 160728 6383 10082 6385 6382 143 79668 4363 338 54956 64087 5096 25974 686 8884 221914 5091 9672 56922 3141 31 32 2239 60386 5095 1504 29914 53630 5826 2262 160428 207 80704 54981 54625 440387 2817 6573 55788 57107 83875 81693 51805 2350 8029 4522 4524 55312 2719 3339 316 5593 4907 4552 51293 26020 4548 5644 79581 56965 9962 5406 9963 56997 335 336 337 79934 10797 9390 8644 344 345 4594 348 113235 83666 29967 27304 84875 6472 200895 375790 6470 5805 10243 808 1719 1727 9227 27249 683 10229 48 113278 54 57017 27231 3949 27235 57016 23590 326625 166785 55163 83594 93100 23057 2644 2643 4837 8566 55191 4846 1645 79178 55937 2694 9446 51109 81034 7274 7276 23475 441024 4023 128240 51117 952 1208 25902 84842 8034 8875 8876 5167 5168 5169 79001 2194 80025 284439 27010 254552 55328 80347 53354 79877 79646 60496 133686 79717 55229 55065 60490 55034 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway 10454 842 64170 64127 83737 841 6885 8767 3551 5608 7334 1147 7335 7189 8517 10392 835 257397 330 3654 14 23118 5603 6300 3656 1432 1540 834 7128 837 329 5600 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB 208 57761 5170 117145 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines 5687 6611 5688 5689 5700 5701 196743 1728 5702 5704 5705 79814 4947 51686 9861 4946 5682 262 5683 5684 5685 5686 4953 5717 5718 5719 11047 6723 10213 5713 5714 7979 113451 6303 5690 5691 5692 5693 5694 5695 5706 5707 5708 51582 5709 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption 11181 6248 248 8513 6518 8972 8544 2980 280 119548 27159 1118 278 279 2984 1056 2981 5407 5408 6523 3938 6476 1208 6514 5406 G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase 1871 1017 890 8900 1869 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins 3295 8540 6342 219743 5264 51 30 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly 4343 192669 23112 27327 26523 27161 192670 57690 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 140735 9738 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 4218 11116 4751 5048 55142 22897 54930 5116 79959 28514 80184 5518 93323 7277 23354 22981 8481 80254 983 121441 55755 54820 10806 10121 5566 55835 55559 8636 11258 84131 4957 4851 200894 7161 1874 3842 56623 9742 23322 55081 55764 79659 8100 51098 79809 26160 6608 11127 57728 57539 54903 89891 6991 64792 9321 92104 11020 57560 83657 150737 83658 200132 56912 51668 255758 51626 112752 90410 23059 55112 26146 28981 57576 79989 80173 6753 5147 27241 5310 5311 261734 55212 117177 51134 403 10013 51259 54806 4735 6010 6950 7203 23265 92482 84902 84747 378 60412 84100 54536 4867 2847 9657 91147 27077 85302 10640 11336 129880 149371 347240 1262 1260 22832 10694 57787 57545 10576 1258 4602 123016 10575 55763 79738 8729 26005 166379 55770 79600 26123 79969 50807 8195 132320 6102 8766 146057 582 583 54585 22920 585 27031 51053 79867 192668 9727 1875 9371 22948 29841 3797 80776 7027 2302 10309 124093 5990 5991 647309 159989 79598 345643 57822 79977 RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events 5959 5956 9227 7276 24 5947 145226 6017 611 64220 2652 222236 5950 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin 340351 84871 113457 347733 10383 10382 7278 7280 81027 7846 10376 260334 347688 25809 23287 254173 25941 374969 60509 10381 79739 54839 158135 284076 112714 22846 9654 164395 123624 26140 84790 23170 23093 83887 79841 91978 84617 84276 150465 79805 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease 6774 2549 5295 10818 5290 11160 1523 9530 613 26127 11116 399687 6777 6776 2247 6772 5335 2260 2251 8805 4893 9846 7750 6654 2254 8074 2249 3265 2246 11052 9208 26281 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis 866 1589 3291 1586 3284 3290 5443 1585 3283 1584 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 2812 2677 2815 2160 2814 2811 2159 2158 2157 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 2247 2248 2255 5335 27006 2254 8074 2249 2246 2251 26281 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking 51070 4846 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 999 6657 201595 10085 727936 5054 5829 3673 1000 6935 7837 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events 23507 57185 57380 56172 152519 55144 54896 1497 6005 119 79815 56262 93380 81614 563 2039 348938 5304 80131 123606 84230 84061 118 7991 120 57127 51458 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription 3312 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs 51495 11000 79071 197322 51703 3293 401494 9524 23305 253017 83401 9200 51144 81616 2182 2181 60481 6785 2180 64834 79993 23205 54898 201562 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs 57533 10133 11337 11021 51560 79735 5869 26000 26088 84958 4218 5878 374403 57465 5867 23163 51762 7879 5868 83874 23062 7248 11345 5870 8408 7249 729873 9230 83452 4943 51256 81631 23637 64786 9363 8766 128637 27342 9135 338382 125058 382 54662 55357 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding 9965 152831 2264 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus 54492 7316 54567 57534 5664 5663 11060 3714 55851 83464 28514 1950 1956 7311 182 102 7314 4854 9148 142678 6233 23385 51107 10460 4904 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 11001 122970 10005 3295 8309 10478 26061 215 79777 55289 8310 54677 51179 55825 390916 1384 283927 1962 5264 26063 91452 23600 30 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation 4967 1738 92259 1743 275 2653 2731 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly 389203 1355 1353 4512 90639 4513 4514 116228 341947 285521 25994 80775 1327 493753 29090 51204 51241 9997 84987 125965 1329 1340 10063 9377 1337 6341 1339 93058 152100 1351 1350 4697 79064 100303755 100131801 55744 1349 1347 1346 1345 6834 192286 9167 80219 28958 84701 55969 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD 2694 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression 4802 1051 6347 1649 1054 22926 1965 8894 11340 8570 9451 1968 23404 9709 54512 3309 3576 5393 23016 5073 51010 167227 51013 118460 22894 440 56915 3484 468 4800 467 4801 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 3320 2064 11140 55914 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins 51602 55746 7341 6045 23279 3190 79023 648 6015 10762 23165 6396 1912 7703 1911 129401 7329 9631 6613 7175 80012 4927 57332 84733 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 3183 8086 53371 8480 79902 8535 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs 5436 5438 8341 8342 8970 5439 8347 8370 8348 128312 8345 94239 8340 55766 27327 8968 26523 27161 10526 3013 8338 5430 5431 255626 5432 5440 5433 5441 3021 85236 8349 5901 3018 3017 54145 3014 653604 5434 5435 5437 8331 8337 8334 8335 474382 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism 51268 1738 55526 89874 10157 1743 1428 123688 2639 501 85007 51166 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex 6885 7316 10454 7098 7311 257397 7314 148022 7189 6233 23118 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation 3146 836 3837 3009 3008 3007 3006 3005 1677 1676 3024 3148 3836 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction 639 378807 63979 117144 117155 55732 79820 157855 57828 347732 257062 94239 7852 56979 7022 4292 54145 472 8331 8337 5932 8334 8335 6117 6119 6118 8341 8342 8347 8348 8345 8340 6677 8338 22917 5460 5016 9139 49 10630 100129669 57829 25777 126123 2515 342977 113177 7783 11085 7784 85236 284359 8747 8349 8748 8290 8468 7156 4683 8370 26277 25913 8320 65057 3013 641 7329 7013 7014 79923 54386 255626 2683 3021 10111 4361 3018 3017 3014 545 9985 27127 10734 672 11144 50511 93426 10388 23626 23345 474382 23224 256126 56158 6847 644186 1019 23353 5889 29893 3306 8970 27030 84057 1017 128312 4438 4439 54790 55766 9126 8968 928 10735 652 10274 8243 5885 64321 653604 4001 5888 84329 675 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling 1809 1400 8829 1808 55558 91584 5361 2534 10570 10371 56896 2242 1020 2932 8851 5362 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine 389396 219970 348158 92292 123876 341392 10249 54988 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 80339 57104 84649 11343 347516 158835 8694 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) 1356 30061 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants 5518 1452 1499 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 26275 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding 59345 23236 2793 2792 2791 2790 2900 2782 2788 2787 2786 2785 2901 2784 2783 10681 51764 1739 2899 2898 2897 94235 1742 808 5330 55970 5331 83988 1741 54331 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling 7316 4734 6714 7311 7314 11059 83737 6233 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction 5959 5956 9227 7276 24 5947 145226 6017 611 64220 2652 222236 5950 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) 3423 OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins 221391 5956 23596 5995 6010 611 2652 10692 94233 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle 9212 5687 5688 5689 5700 5701 9184 5702 991 5704 5925 26271 5705 890 8900 4085 701 9232 8556 6790 8454 6233 7321 25906 11065 8697 7324 6502 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 1017 51433 5347 4751 9861 5682 891 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome 10454 64127 51231 1849 1848 1846 1845 4791 257397 8454 6233 351 4790 5970 7316 7099 929 7186 353376 23643 148022 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 3665 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 57161 3725 57162 177 23118 121457 28511 80216 54106 5519 1432 5515 5516 5600 5528 5598 6885 7189 51295 51284 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib 3320 2064 11140 55914 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein 578 637 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex 6885 7316 3656 10454 7311 257397 7314 7189 6233 23118 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity 3827 2161 708 3848 3273 710 2 3818 5329 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors 7157 23368 7159 10848 8626 207 7161 10000 208 25946 5457 54971 51230 5458 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK 9138 9181 27237 23365 6655 128272 11214 121512 1894 10451 5599 23370 25791 7410 23229 50649 50650 9826 9828 7409 4803 22899 26230 6453 8997 8874 10276 55701 100271715 54848 5924 389337 445328 9459 10672 84904 26084 4168 55160 2245 57580 7204 5879 57449 7074 4804 9500 26574 29 64857 89846 6654 23263 221472 9639 572 10018 7984 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking 1212 10052 1601 57165 8218 375519 57369 2702 2701 2700 127534 2709 2707 2703 219770 125111 1785 1213 10804 1211 81025 1759 84694 2706 2705 4646 2697 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER 7316 5111 6119 10714 6118 51426 5424 57804 10038 2067 9978 404672 1642 2071 2068 54107 7507 142 5982 5983 2966 7311 2965 7314 8451 6233 5981 1643 8450 2073 2072 56655 5984 2968 5985 2967 9557 5425 5426 5427 6117 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints 23421 51143 64105 993 79858 8454 57060 8655 472 6233 7321 1781 25906 11065 144715 8697 7324 5810 10393 1778 29945 5932 29882 996 1454 11073 699 51529 8881 64682 6117 7316 6119 27338 140735 119504 6118 246184 25936 4194 9793 1029 7532 51434 7531 51433 23332 6232 8317 79980 23291 4193 54908 1111 5347 22919 9656 7334 10524 7486 5048 9861 5982 5983 5682 891 5683 151246 1263 5684 8945 84515 4172 9735 5685 4173 5686 4174 84126 4175 5717 5518 4176 5718 5719 8318 9133 7311 7314 4171 11047 6500 10213 5713 5714 1026 7979 983 220134 5690 57082 54820 5691 5984 5692 5985 5501 5693 5694 5883 5695 6249 5884 5706 116028 5707 5708 5709 9212 7156 5687 5688 5689 4683 5700 5701 54821 9184 5702 5704 23122 991 5705 890 8900 4085 10971 3364 701 995 641 55920 7514 7534 11200 10111 4361 1763 7529 11243 2810 545 80010 1432 25946 672 5600 9156 11130 332 1452 51512 9978 55839 83695 8379 580 55166 79019 7468 9088 79003 55055 81565 147841 10926 55388 401541 7533 165918 7158 378708 1780 79172 64326 1783 83540 80152 54145 3619 64946 348995 57122 55746 8341 8342 8347 8348 8345 23279 79023 8340 6396 7336 5905 85236 8349 1062 5903 990 5000 5001 7465 23595 8290 23594 2932 4998 79902 4999 51230 25909 898 9183 8370 9134 81930 51588 84643 3796 63967 57405 255626 7157 10403 3018 3017 80776 3014 5519 5525 5515 5526 5516 5527 11004 5528 29086 5529 9025 91687 8924 51720 57551 84142 79682 9577 79184 8970 1017 128312 1027 2491 55143 10726 1063 83990 1060 151648 1058 348235 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 2153 5624 5627 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription 51082 5928 10849 6908 4331 57504 30834 8370 902 5931 404672 94239 9219 1107 9112 3013 221830 1108 7343 8932 255626 5440 5441 3021 54815 2966 9533 2965 3018 3017 54145 3014 5434 5435 5437 53615 8331 2968 8337 2967 8334 9014 8335 1022 9015 9013 474382 10919 8341 11335 8342 84172 8970 8347 8850 8348 128312 8345 2074 2071 8340 55766 84295 2068 284119 8968 54700 8338 25885 85236 8349 3066 3065 653604 5595 64425 2648 7270 79101 57459 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors 147 148 151 153 154 155 150 152 146 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer 4851 8454 9978 6500 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway 111 112 156 113 114 5137 814 115 5153 815 5136 5613 816 817 818 196883 5582 5580 5573 5575 5576 107 108 5567 5578 109 5568 808 10645 84254 5566 3838 26960 5577 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion 7316 7879 5868 26276 7311 7314 9146 6233 11151 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic 9554 9371 221458 9493 9183 547 55083 81930 84643 3796 84364 3797 113220 3831 4905 26958 3798 3832 3799 3833 55850 3834 51014 3835 90990 10945 285643 23423 372 23095 10749 381 662 9276 81876 124602 10959 11316 56992 375 60561 377 22818 89953 1314 54732 11004 51226 53407 64147 22820 8775 51594 1315 11014 5861 6836 378 11127 55738 8774 10972 9585 8729 23046 24137 1062 64837 26153 63908 147700 11015 55605 26286 22920 55614 146909 55582 23303 29127 10112 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology 5928 3861 5929 3866 10319 3868 9968 9969 896 3192 5266 3280 597 25925 25937 80306 1272 5054 7004 7003 10498 23493 9861 5682 23462 6514 5683 5684 7039 5685 5686 28514 5717 51592 3516 5718 5719 1499 9464 84667 11047 10213 5713 5714 7979 3955 343930 5690 5691 5692 134701 5693 5694 5695 2043 5706 5707 145873 5708 5709 51176 4851 5687 5688 5689 6911 5700 5701 10683 5702 5704 5705 5915 5916 427 3312 7514 5578 7534 1981 207 7529 1432 3549 26986 5600 8650 9978 91584 7703 5576 5567 5568 6122 6124 6123 6125 6886 6130 6133 6132 1605 6135 6662 4893 6134 6137 6136 3265 6128 6129 5921 6142 6141 6144 22916 6143 6146 6147 8861 5293 6139 4686 6138 6152 3174 6155 6154 6157 7525 6156 5430 6159 6158 5431 5432 6164 6166 5433 6165 7852 6168 6688 6167 6169 6160 6161 6175 6176 6171 6170 6173 5436 6921 5438 6181 5439 6923 5873 4086 4087 4088 4089 112950 2904 8463 9314 9255 3978 22797 1908 3094 1906 4157 1910 27022 257 6926 4161 8600 1879 4286 6663 5454 1463 3397 4160 7030 4159 7942 6456 1175 160 161 163 26052 3690 1785 1213 1211 1759 1346 5730 7484 153572 9037 6495 6299 130497 79192 6092 2296 7481 2625 6928 2668 10736 2303 652 57526 2247 3237 3214 3975 5979 5076 116832 9353 5455 2122 182 54361 7490 3172 3207 255743 2018 10406 3227 2138 3203 2674 3400 26585 8516 3688 51316 7849 4609 5295 5296 10818 5290 5291 4343 192669 23112 27327 26523 27161 192670 57690 595 861 864 865 7040 200916 7965 7022 7021 219541 9114 7020 4790 523 526 527 528 529 5970 1051 1029 6934 5453 5015 6230 6656 6232 533 7546 6231 6234 4935 6235 6227 6229 6228 3952 50937 288 9550 8992 6383 23389 23396 2534 3326 6188 6187 6189 8459 6935 9839 4209 6732 2817 10048 5781 9349 6191 6193 6192 7305 7480 6194 54209 25924 3921 8829 83401 201595 10000 2197 8660 140032 1761 6736 10974 688 5617 27332 6517 168544 6201 1212 6203 6202 7533 96764 208 7471 375790 10570 10371 56896 2242 6210 57556 2766 10507 5532 6237 5788 80031 51065 5362 5365 6205 9723 6204 8218 64218 6207 971 6206 10154 6209 3672 6208 6223 1809 6222 8482 1400 6224 1808 55558 1000 9043 1013 1496 4207 6218 6300 6217 4917 663 1002 4756 782 785 4185 112755 9211 59283 163175 55203 8745 203190 10369 27092 4233 53616 2549 10368 374 6478 6477 2255 2252 89780 5460 5077 7545 4487 5081 83439 6657 1749 4602 24137 998 8453 3848 2624 84441 9794 2627 2626 55534 285643 4853 23414 1869 3725 2294 22938 7027 7029 10046 5598 2909 2034 1019 1017 5829 1796 1793 5879 387 51606 10664 6775 5062 3458 55740 3595 1072 7408 4478 5306 22794 9939 994 1441 65109 9775 1739 10921 55110 4116 7430 7220 4627 25904 7222 4850 7224 7223 7225 4848 4849 5962 4308 4651 4644 4664 4665 1959 55571 404203 4014 57113 26239 6707 84648 353132 353131 6700 643414 11187 6701 6704 643418 6703 3713 6706 6705 643394 246175 63036 353134 43847 6712 23254 353133 4067 43849 64065 353135 3221 7051 5588 353137 353139 26085 5608 126638 10524 199834 353141 2312 8851 149018 353140 7074 353143 2353 353142 2645 1825 1824 1823 4174 5046 6698 353145 85456 353144 1041 7062 448835 4171 1830 2125 23019 23581 1475 1026 142910 6768 5317 11005 5594 11202 5595 147409 5604 5318 5605 9333 5493 6654 2254 25818 5652 254910 2249 6699 340654 9337 57472 3630 9125 634 219699 8633 1630 9423 90249 137970 29883 140801 6586 4753 672 55588 81857 7903 23405 129563 5620 201516 100288687 503835 5619 1975 1974 1973 342900 678 1977 5859 8106 390245 7290 503627 55211 286 100033411 27255 54766 3673 285051 8515 79670 10752 284355 23318 132243 10361 390748 359787 10605 124512 57379 151871 83933 6721 10765 1741 23135 51121 5443 2902 55869 27330 4211 3200 9063 9935 3211 3201 63925 3213 3212 5316 3233 3232 23521 3198 3231 390874 256297 79444 5080 6927 50674 4821 4825 3170 4760 3651 3375 3175 63976 389692 3171 222546 3642 5927 4141 8912 79966 8976 6093 1832 8503 8502 1828 1969 3815 63978 6997 51520 7547 84891 79727 7341 5664 130399 6256 91 5465 92 64344 93 8928 9350 4617 4618 55851 9759 5468 83464 7329 9241 64283 9412 5914 2516 6925 4628 6909 4629 79083 268 2315 7157 57522 6490 10085 727936 1495 54843 1460 79784 3685 4654 4656 10589 1459 1457 51107 4637 4650 6709 27289 9441 2253 51586 6711 5747 6714 7026 6722 6387 84498 3169 4690 7391 7299 9046 64321 6464 23767 5087 9901 9495 4099 400569 6655 55090 10451 23097 2887 5216 5217 9045 9355 8022 23053 23708 7410 1950 6091 5335 26019 5917 56956 2064 3670 1956 23032 10109 2107 9826 89884 65110 3735 4440 6585 6233 3199 1287 3320 5361 2935 5364 6453 8997 8874 84962 10552 7316 7532 9855 7531 80728 256076 23332 7837 10093 5347 10092 10095 10094 7204 10097 1595 6804 10096 1286 1285 891 1284 1282 7311 80205 7314 131873 27 1293 1292 1291 1149 23380 5566 6837 8440 5058 596 28964 6774 388 389 5663 5063 3914 23122 3915 23365 3918 1299 1298 999 23129 8320 6862 145258 3911 387332 3912 79923 83881 6591 10298 11224 3376 25791 5045 25873 1829 6615 23385 7044 57167 51466 71 9846 10398 6386 823 775 776 826 1729 783 784 2335 2058 56924 4838 10637 55997 6998 199699 1052 54797 4140 9475 1297 102 3909 5105 4313 1742 4318 9862 9421 93649 6595 150572 57057 55897 4297 6597 6899 6599 6598 6907 57504 8648 10891 5931 94239 9967 7306 9070 1107 23054 57144 1108 22976 3728 25 29128 54815 9521 2886 8202 54145 948 53615 58508 8331 8337 8334 3984 8335 3985 103910 200424 1020 7124 8535 4772 84246 4773 4094 10538 5977 51564 7913 6348 6304 8341 10013 8342 10014 8347 8348 6469 6045 8345 79885 7350 3567 9048 3566 3565 779 6900 2113 64096 648 8340 7528 4902 4684 6015 3662 2675 5621 23466 79447 8913 51621 30009 1024 5623 8911 1912 1387 1911 5451 60 5452 8338 605 9734 9443 3596 80012 57332 8110 84733 6777 9442 6776 6778 9440 85441 85236 6601 8349 6603 9439 728279 3880 6602 3881 6605 286887 6604 3882 353323 54474 81850 81851 3872 3875 284217 643812 140807 22885 1050 3890 2676 3891 3897 3892 7015 285220 2932 353332 3785 353333 30011 3786 2313 3680 57459 3883 6708 3884 10627 3885 100133941 3886 2596 86 3887 6710 3888 6932 4897 728299 148738 2033 162605 57453 26039 81870 8370 57698 81871 5649 51003 81872 2146 2045 390792 2044 728224 2042 100505753 2041 1615 440051 5786 440050 116986 9219 728255 10499 2051 1053 51129 2050 192666 2049 25984 9477 2048 440021 6760 2047 1435 100505724 2046 9112 100533177 8828 338785 4221 56963 3013 440023 10486 84059 10487 90390 4359 8986 8128 100131902 6324 6323 57716 6197 53358 4155 6196 11313 643803 6195 10025 6331 337979 4205 6330 337978 4208 255626 6332 337977 5440 6335 337976 6334 337975 5441 214 196374 9252 6326 344022 3021 8506 337969 6328 337967 1638 6327 337966 6329 337974 892 57731 337973 6336 337972 3018 84448 337971 3017 7436 337970 2167 11280 144501 3014 59277 337959 5434 337963 220164 5435 337960 55800 5437 64641 1943 287 51350 2309 79718 1942 728318 2308 51332 388818 10413 7448 1949 84616 1948 386684 386683 1826 1947 386685 6910 1946 374454 386680 55816 8289 1945 386682 1944 386681 85358 386677 8841 1482 386679 474382 23114 386678 1600 9370 6929 55715 386672 386675 1641 50846 57492 9260 386674 10001 23090 284656 5909 2657 100132476 285704 8970 3983 2672 100288323 8850 128312 83902 7094 121391 83901 25942 83900 387264 100507608 387273 55766 57211 254950 387266 8726 387267 8968 353288 6938 125115 4023 3156 23411 1821 147183 85291 9274 85290 9275 85293 85294 85280 29079 57830 85289 85285 3908 5376 337879 3913 3570 5346 337882 3910 337880 7403 100132386 3674 5469 140258 8688 3678 8689 8687 133522 2260 112802 83899 9282 83895 8193 83897 655 3066 83896 3065 9119 284827 4303 653604 653240 319101 3849 342574 84661 3846 3860 7402 2648 3858 11091 3859 3850 3851 9612 3852 3853 3854 9611 3855 4736 3856 23512 3857 439915 8085 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 6772 6774 8503 5295 5296 5290 4067 2534 4893 3717 6654 3815 7525 3265 6777 6776 3932 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation 2247 2254 8074 2249 2246 2251 8823 8817 26281 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis 10974 5928 400569 688 27332 6907 6517 9968 57504 168544 9969 8648 896 10891 5931 3192 96764 9967 55090 1107 23054 7471 1108 23097 7040 54815 219541 8202 80306 4790 948 53615 63976 1959 7124 84246 5970 1051 7350 4086 4089 10498 1024 1387 112950 9443 3952 9442 9440 9314 85441 80205 9439 6604 1149 1050 6837 57459 2033 51003 6256 23389 5465 1879 9219 10499 51129 9477 9112 5468 90390 9412 10025 892 2167 64641 79718 1346 55588 9441 8841 9370 51586 10001 1019 23090 81857 7480 7026 4023 1052 84498 54797 29079 5346 5469 133522 9282 6721 655 5105 3066 3065 83401 9862 9612 9611 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport 9554 51143 1780 4905 26958 55850 1783 51014 10945 23423 372 381 8655 662 1781 9276 81876 11316 375 377 1778 60561 22818 1314 54732 51226 53407 22820 140735 51594 11014 5861 51560 25782 6836 378 10540 55738 8774 5048 93661 22930 22931 10972 55860 9585 8729 23046 24137 1062 64837 1639 26153 63908 51164 147700 84516 11015 55605 10671 22920 55614 10121 146909 55582 11258 23303 29127 10112 9371 221458 9493 9183 547 2589 829 55083 81930 84643 830 832 3796 84364 3797 113220 3831 3798 3832 3799 3833 3834 5870 3835 90990 285643 23095 10749 56894 124602 10959 56992 89953 11004 64147 8775 1315 8398 2590 636 23299 5321 5050 5049 11127 26286 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis 441282 3294 1588 51171 3292 51170 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis 59345 5777 5051 3708 5152 3709 5153 338 5136 2977 10846 2983 27345 2268 2982 3710 10242 5138 4842 2782 50940 27094 3778 3779 10335 10681 5175 4846 7222 7225 808 487 488 5027 7804 5519 1432 489 6543 6546 5525 5025 6547 5515 490 5526 491 5516 492 5527 493 5528 6717 57113 5529 5781 5023 5024 9127 5026 2793 2792 22953 6786 2791 80228 2790 84876 2788 5321 2787 2786 2785 2784 2783 8654 51764 2778 5593 4843 5739 5518 94235 55970 54331 DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants 238 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion 2767 5578 4082 23236 5330 2776 5331 9630 2769 1131 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression 10891 7306 4343 597 192669 994 23112 27327 26523 208 27161 192670 57690 595 2766 9114 1000 79444 7020 4308 4644 523 526 527 528 529 5977 4233 1029 6934 5054 533 5873 4935 7837 3662 5347 60 605 8110 891 83439 6657 4174 6601 1499 9550 6603 4171 6602 6605 1026 6604 8992 3978 7015 51176 596 86 3094 6932 26039 6663 5454 999 6760 427 634 6909 79083 2315 6490 10085 727936 54843 1638 6935 1432 672 8289 57492 23405 1729 1017 5829 25942 23411 9274 9275 3673 25924 51606 7391 7299 8193 3065 201595 6595 6597 6599 6598 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 5335 4916 4908 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis 2592 79947 10020 54344 2673 5236 22845 79644 5373 2584 4351 8813 8818 2582 116150 130589 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters 8313 6932 6934 1499 864 83439 4609 51176 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated 5518 1452 1499 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence 1019 1029 1021 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease 7316 598 5295 6711 2120 5290 2885 399687 2804 6777 2323 6776 867 9321 2322 7311 7314 6233 50507 1026 4893 9846 7750 6654 5292 3265 5781 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation 5977 57492 86 26039 5873 4935 6663 7306 3662 6760 208 60 9274 605 9275 25924 8110 79083 2315 6490 7391 7299 54843 1638 6601 1499 6603 8193 7020 6602 6605 6604 1432 4644 6595 8289 6597 6599 6598 51176 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT 388 389 79784 4627 1027 1742 5500 9928 9055 4637 10398 11113 5879 103910 4659 4628 4660 4629 387 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids 35 3032 37 3030 142827 6296 33 3033 34 1892 51102 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains 5795 3123 3122 3120 3119 3118 3117 917 3115 3113 915 916 1445 3127 55824 3126 3125 920 5788 26191 3932 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed 6612 7341 59343 29843 6613 205564 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 4803 11108 4804 3066 8841 3065 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated 324 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway 4851 51564 6907 10013 10014 8850 79885 1387 9759 55869 9734 84441 9794 3516 55534 4853 83933 4854 4855 3066 3065 22938 79718 2648 9612 10046 9611 8841 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome 7316 5687 5688 5689 5700 5701 51684 1452 5702 5704 9978 5705 9861 5682 5683 5567 5684 8945 5685 5568 5686 5717 2737 5718 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5566 5695 5706 5707 2932 5708 5709 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants 2322 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation 2247 9965 152831 2254 8074 2249 2264 2246 2251 8823 8817 26281 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 3708 6616 3709 2864 3710 2771 2770 10554 6794 6945 8826 948 3745 5330 3747 5331 5577 23236 2793 2792 2791 47 2790 2788 3767 2787 2786 2785 2784 2783 51764 6804 6513 3790 1131 6514 10768 6812 5518 9254 9630 94235 5906 55970 5566 6833 7086 54331 2767 11069 59345 6844 6861 2769 51422 2782 4082 31 2642 32 2641 2776 10681 3630 5207 150 152 5578 26251 51085 51094 5519 5563 5565 5515 5516 773 5528 775 776 777 9370 111 112 113 6888 114 115 783 784 196883 5573 5575 5576 2778 107 108 5567 109 5568 2194 79602 10411 2182 2181 2740 9495 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation 9397 23576 114757 4836 340481 857 4846 10434 207 808 3320 80777 6697 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 56656 120065 121275 120066 283365 390883 390882 390649 390648 124538 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219865 219986 219983 219982 390892 219981 401994 401993 401992 285659 81309 79473 81797 390538 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 219869 347168 26716 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 126541 338662 403282 403284 127623 254879 283297 219429 255725 284383 219428 126370 219447 390271 390151 390152 391121 441308 390154 390275 390155 441669 390157 390036 390037 390038 441670 158131 138882 138883 138881 23538 390162 219453 390167 390168 347468 219469 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 390081 390082 390083 390084 26687 119749 26689 402135 219493 81168 81285 392391 81282 392390 504190 390174 8861 390054 26533 256892 390058 26532 390059 26534 26658 26539 26659 26538 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 81061 390190 390191 403274 127062 403277 403278 127069 127068 127066 127064 403273 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 119679 390093 403253 392392 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 391192 346525 391191 391194 391196 391195 403244 128366 128367 128368 128360 119774 119772 26740 403239 346517 79490 81328 120586 256148 81696 81697 8387 8388 8386 8383 81318 79482 81448 81327 81442 132112 393046 8390 8392 122742 26494 26493 401427 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 1879 122748 127074 341152 256144 127077 283617 120796 81469 119694 119695 120793 81466 282763 81341 343563 119692 387748 344892 79290 79296 135924 79295 26595 26476 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 26692 402317 26693 81399 26333 26696 26212 26211 81392 388761 343406 26341 9355 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels 131096 3768 3784 3756 3736 23416 9312 10021 90134 3780 3773 93107 3782 23415 9196 3783 348980 169522 57657 3748 610 3749 170850 27012 27133 3742 3787 3743 3788 3744 3746 10060 3781 9568 8514 3741 9132 3745 3747 2793 2792 2791 2790 2788 3767 2787 2786 2785 2784 2783 51764 3790 9424 3775 10089 94235 55970 6833 3785 3786 54331 59345 27345 10242 2782 27094 3778 3779 10681 3770 338567 83795 89822 26251 54207 3776 56659 50801 3750 3751 3752 3758 3764 3760 3761 2550 3759 3777 51305 3772 3757 7881 3737 56479 3738 3762 3739 3763 81033 3754 3765 3755 3766 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters 169026 7781 23516 7780 64116 29986 25800 57181 27173 29985 283375 64924 7922 55630 7779 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE 7098 148022 7187 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 84295 8968 3013 8338 7343 8932 255626 3021 85236 8349 3018 3017 54145 3014 653604 5595 8331 8337 8334 8335 474382 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer 2280 7046 7040 7048 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade 2549 5295 30849 5296 10818 5290 5291 3667 3480 208 2248 3479 2255 2252 27006 8471 2323 3481 2247 2322 5289 2264 2251 117145 9965 54106 152831 5140 4893 9846 6654 57761 2254 5170 8074 2249 8660 3265 2246 8823 5781 8817 26281 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 4851 54492 54567 6907 26508 2033 57534 5664 5663 3280 3714 55851 9759 6868 83464 55869 84441 9794 55534 388585 892 8454 6233 22938 23385 51107 79718 10046 8841 7316 51564 10013 10014 8850 79885 9978 1024 1387 23493 9734 23462 28514 3516 83933 7311 182 102 7314 9148 6500 3066 3065 142678 2648 9612 9611 4609 CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT 808 5534 4775 2280 5530 5532 4772 4773 5478 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 4056 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 2247 5335 2251 2248 2255 2252 27006 2254 8074 2249 2246 8823 8817 26281 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling 6091 9353 10486 10487 23122 23332 25 27 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency 686 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 79661 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors 9890 64748 54886 23566 8698 53637 163404 1901 79948 57121 1902 9170 9294 1903 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency 1373 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 246330 3551 7334 1147 57161 7335 57162 7189 8517 3654 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs 7316 5887 5071 126119 7311 92552 7314 9929 4287 6233 7415 5886 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis 192669 26523 27161 192670 23405 8575 7257 6895 7247 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) 9056 6520 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling 2247 10818 2251 2248 4893 2255 6654 27006 2254 8074 2249 3265 2246 10817 5781 26281 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly 838 DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS 170692 11093 145173 57188 10417 10418 170689 171019 54437 9037 5199 7058 9510 157869 56999 11096 9507 140766 80070 11095 9508 9509 339366 221981 79875 81794 55901 81792 7057 9719 11173 11174 80731 54507 92949 170691 170690 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events 4249 50636 7341 2589 51201 54956 100128731 25834 55129 83666 10610 196527 84875 79844 5589 57719 7329 25921 5045 6185 23193 2530 6184 6233 121601 2931 6733 11253 746 54625 51114 6732 1603 7841 7316 203859 57101 1452 51125 63982 253832 338440 6483 6482 6484 6487 84061 6480 256435 27090 55741 11282 11320 7991 7311 29801 7314 4245 4124 51304 3276 55107 56965 201595 3703 7113 59272 143 2932 58505 1650 79668 4247 821 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation 91433 11338 79831 51389 6194 100137047 55239 2107 444 23210 6132 6228 79697 2158 84864 1819 6157 55854 4733 65094 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR 5610 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 10919 10179 8341 8342 8970 8347 8370 8348 128312 8345 79813 94239 8340 22880 55766 55729 8968 9869 51535 3013 8338 255626 3021 85236 8349 3018 3017 54145 55596 3014 653604 23272 54737 8331 8337 8334 8335 23517 474382 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 7378 1633 7371 83549 978 151531 7084 7083 54963 1890 8226 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers 5928 3708 3709 5295 5296 10818 5290 5291 3710 3667 4343 192669 23112 27327 26523 27161 192670 57690 3643 5156 1950 5305 5335 2064 1956 2251 6233 79837 7409 8649 5581 5577 7316 10542 156 5137 253260 389541 28956 4193 57521 11060 6009 4915 627 9861 5682 5683 10768 7039 5684 5685 5686 5717 5518 5718 5719 55004 7311 7314 11047 10213 5713 3654 5714 1026 7979 2475 1386 5690 5594 5691 5595 5692 5693 58528 5694 5566 5170 2254 5695 8074 5706 2249 5707 2246 5708 8823 5709 8817 572 26281 842 5687 5688 5689 5153 5700 5701 5136 5702 79109 5704 5705 391 23396 2534 5580 55615 3630 6591 5155 118788 51135 2323 4615 930 5159 6801 5578 23035 84335 940 941 2322 942 1822 84232 1958 2264 23239 64223 6615 7874 6199 8975 207 81847 50852 23252 90865 5987 2931 8870 8658 9965 80351 57167 2444 152831 10645 9173 84254 9846 57761 255324 5781 64121 111 112 113 114 115 6446 10670 5371 153129 196883 5573 10325 5575 5576 80243 7189 107 108 5567 109 5568 10000 5978 8660 26960 3838 3932 57504 5294 3164 5931 5293 1107 208 5582 1108 54815 808 53615 8535 3082 51564 4233 7101 2549 23533 374 10014 6045 23608 648 6015 23466 1912 2248 1911 2255 2252 27006 80012 57332 8396 84733 8394 8395 7249 8503 10273 4734 331 3815 4916 2932 4908 23028 57459 146850 2146 2099 9219 9112 5468 1147 7157 1460 1459 117145 3725 1457 2309 5519 2308 23186 5525 5515 5526 5516 5527 5528 5529 8841 9542 3084 814 815 816 5613 6714 5880 2069 817 818 5728 1027 685 2100 8726 10718 1839 5879 145957 2247 2122 3066 3065 4303 23512 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation 8038 9644 8751 8728 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death 11035 8772 7098 148022 841 8737 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm 2626 3549 6469 652 2294 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 5578 4314 4893 6654 1839 1956 3265 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors 5928 57504 8370 5931 94239 9219 1107 9112 3013 1108 8932 255626 3021 54815 3018 3017 54145 3014 53615 8331 8337 8334 8335 8099 26038 474382 2203 55205 6941 22806 22807 8341 57592 8342 23613 8970 8347 10263 8348 128312 8345 9640 7026 8340 10320 55766 152485 84295 8968 8338 2538 85236 8349 5105 3066 3065 653604 7182 57459 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion 22868 51106 387338 26995 51335 81554 55178 79922 130916 51001 84881 285367 29960 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase 3784 27092 9254 23630 59285 59284 783 10142 782 3753 9992 23704 775 59283 10008 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane 10454 64127 7100 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 51231 246330 2002 1849 5599 9097 1848 9252 3146 1846 6285 1326 1845 6288 5609 11274 466 6283 6416 9683 4791 5601 9684 257397 7867 8454 4793 5602 28512 5606 57161 3725 57162 6233 177 23118 121457 351 4790 28511 80216 5519 1432 5515 5516 5600 5528 5598 5970 7316 7186 23291 841 6885 8767 4792 5608 7334 7335 7189 2353 8945 81793 5518 51295 7311 7314 6500 3654 3656 5594 1386 5595 5604 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 5436 6921 4331 5438 6924 5439 6923 902 404672 22916 2071 7469 8178 2068 4686 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 2966 51497 2965 11198 25920 5434 5435 51224 5437 7936 2968 2967 1022 2963 2962 904 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes 127124 23545 51382 5880 653361 533 534 535 4842 50617 1536 1535 51606 4353 245972 245973 4843 155066 4846 9114 9550 4688 4689 4025 8992 90423 10312 523 6556 84329 525 526 9296 527 528 529 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) 9187 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis 11035 197259 841 8737 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants 7450 5908 5245 22866 815 816 6714 817 7094 409 818 2335 369 4296 408 3717 10256 3845 3674 283455 4140 2266 7414 3690 5037 2243 54518 7529 673 8826 808 5906 5594 5595 1445 4893 5604 5605 8315 3265 5894 2244 8844 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome 5929 84661 11091 9070 8085 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes 7157 25946 57060 1026 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 111 112 59345 113 114 115 2791 2790 2782 2788 2787 2642 2786 196883 2641 2785 2784 5573 2783 5575 51764 5576 2778 107 108 5567 109 5568 94235 55970 5566 5577 54331 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants 11221 80824 1849 5594 1852 1848 1850 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT 5929 3708 3709 4040 4041 3710 4343 192669 23112 27327 26523 27161 192670 57690 864 343637 5216 83595 5579 8549 55366 51699 51339 9559 25776 440193 340419 84133 9580 8454 55737 6658 6659 79971 6233 284654 50999 59349 56998 59352 55553 5330 23072 5331 1454 7316 6934 10524 9861 5682 5683 5684 8945 5685 80326 5686 5717 5518 5718 5719 1499 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 9736 5709 51176 5687 5688 5689 5700 5701 5702 5704 84870 5705 23002 8724 51384 166 1455 7514 5578 857 7534 207 81847 8658 80351 7473 7472 7475 7477 7476 7479 7478 7480 7482 1452 9978 1488 1487 6885 1855 5593 1857 1856 64840 6662 8452 6597 6736 50855 5145 144165 1212 5534 5158 5148 409 7855 7976 83999 51701 94239 8321 8322 9070 7474 8325 8323 8324 7471 208 4919 6259 5582 4920 5592 5530 5532 2780 2535 81029 2775 8295 9757 8607 54145 808 8331 8337 8334 8335 9101 7483 6423 11197 4772 6422 50964 23236 8341 8342 8347 8348 8345 2793 2792 2791 8340 2790 2788 2787 2786 1387 2785 2784 8338 2783 51764 64750 89780 83439 6657 8395 27121 85236 27123 8349 94235 331 23513 57216 55970 7088 7089 8290 79577 7015 2932 7091 7090 123169 607 54331 90780 8313 283149 59345 26108 6932 2033 8370 57154 2782 54894 4221 3013 10681 255626 1175 3021 160 1460 161 163 3018 1459 1213 3017 1211 1457 3014 8312 23401 5519 324 10023 5525 5515 5526 5516 5527 5528 139285 5529 474382 815 8970 5880 128312 5881 55766 7484 79412 8968 7481 5879 387 57680 22943 64321 54361 54764 3065 653604 84661 11091 4609 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol 11163 170685 9807 117283 64768 9677 55190 11165 3705 23262 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling 9173 90865 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia 54658 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) 340024 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC 90249 842 1613 1612 836 23604 26060 9500 219699 1630 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events 387129 1816 409 5443 1812 2771 1081 2770 135 9287 3363 3362 5140 3360 3375 153 154 155 594857 83551 134864 319100 5577 134860 9038 3274 156 2863 2869 2793 2792 2791 2790 3640 2788 2787 2786 2692 2785 2784 10266 2783 2691 51764 2695 10888 5729 2696 5741 5739 10203 5732 5734 94235 122042 1394 5744 55970 5745 5746 5566 54331 59345 5153 79924 4157 5136 10846 10268 57105 10267 4161 5138 151306 136 2782 50940 346562 4160 2642 2781 4159 2641 3972 797 2773 10681 799 8622 133 7433 6344 7432 6343 7434 5141 5143 796 5144 117579 5139 7252 5151 7253 122876 170589 5150 3973 113091 2492 53831 111 112 113 114 6019 115 1392 6714 157 408 11245 196883 11250 1395 5573 9340 5575 5576 285601 2778 107 108 2838 5567 109 5568 2488 2843 2848 3678 27115 116 5032 2854 117 2852 2850 4158 2870 59350 3688 551 2740 554 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis 10715 9217 55304 123099 259230 151742 4363 171546 124976 94103 165679 253782 94101 9218 388931 80777 5587 1455 10558 2531 142891 8877 23683 25865 79152 204219 8560 29095 56848 79603 166929 5007 9429 9517 29956 91012 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 11277 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades 7099 929 81622 23643 148022 6279 7100 114609 3551 4792 7098 6271 1147 7187 51135 8517 4615 81793 3146 4791 2266 6280 7097 2243 7096 4790 948 695 10333 51284 2244 5970 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 9575 1460 1020 406 1457 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions 3320 3326 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription 4088 4089 2309 864 10018 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction 5921 6774 5295 5296 6714 5290 5291 9564 1398 5155 6777 6776 6778 4690 5159 6772 5156 5335 2886 2889 1399 4893 6654 3265 5781 8440 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling 6932 595 6934 1499 864 83439 4609 51176 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus 3304 GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis 8789 26330 2023 92579 5091 57818 54020 2821 2027 2026 2538 5223 5224 2542 5105 5106 5230 5232 2597 226 229 387712 230 7167 2203 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 2694 81693 8029 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins 7841 7316 7341 2589 54956 83666 10610 84875 5589 6483 6482 7329 6484 6487 6480 256435 27090 7311 7314 23193 4245 6233 2931 56965 54625 143 2932 79668 821 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle 5295 5296 5783 10818 224 57498 392 9928 23129 11180 7126 22852 23048 394 10726 222584 55227 11188 157285 3895 10970 857 55789 8502 91544 81839 27316 9231 9352 23513 57216 56667 253980 23592 667 23074 1828 1969 8153 2802 10817 7037 2909 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol 27124 4952 3628 55586 66036 3613 9108 3612 51477 3631 3632 3633 8867 8821 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 9212 7156 6908 4683 129685 6872 5300 890 6874 8900 6873 3364 51422 26155 6749 641 6881 6880 5562 6883 5564 6882 7157 8148 204851 6884 11200 6794 1460 10111 4361 6790 5571 11198 6875 1459 6878 472 83860 6233 94241 1457 6877 1763 545 144715 6879 1432 80010 5563 5810 5565 672 5932 5600 1020 11073 9156 6117 7316 6119 6118 4194 8550 28996 1017 22974 4193 83695 138474 1111 580 112858 8445 9891 10524 7486 8851 5982 5983 1263 83990 84126 7311 51616 7314 53632 54457 5984 5985 5883 5884 116028 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 51302 9971 1593 196 8648 9915 1589 1588 6256 5443 1585 1584 10499 2232 2230 1545 1595 405 9420 112812 10858 285440 57491 1583 1582 1581 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 5111 5928 91750 286826 132660 898 55957 1017 7153 9134 890 8900 993 1859 1874 4605 4149 1869 3065 7027 983 990 5933 7029 5934 1875 4609 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins 64130 54763 388 6242 114822 389 387 30851 85415 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription 5928 60436 8370 5931 2146 5925 94239 3013 6591 11171 255626 3021 116092 3018 94234 3017 54145 6615 7020 5315 3014 10009 6935 93986 55810 3170 687 9839 348262 8331 8337 117581 7750 8334 8335 387893 8289 474382 6929 8341 8342 8970 6667 8347 8348 128312 8345 1488 8340 1487 55766 8726 8968 6938 23411 7764 8338 9314 85236 8349 7490 3066 3065 653604 7291 54737 5594 5595 7088 6597 23028 23512 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 7514 8021 5901 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors 3274 59340 11255 3269 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization 5928 5925 4613 4343 192669 23112 27327 26523 27161 192670 57690 1009 9789 7410 7020 6233 27085 4790 1500 79872 10399 2060 117581 5970 7316 3569 6667 9855 5817 5819 64398 4193 9743 9861 7074 5682 5683 5684 5685 283106 5686 5046 9159 5717 288 5718 5719 1499 7311 7314 11047 10213 5713 5714 7979 7291 5690 5594 5691 5595 5692 5693 5694 5695 5706 5707 58505 54971 5708 5709 821 5687 5688 5689 6774 5700 5701 50848 60436 5702 5704 56288 5705 100128731 999 23396 6591 1508 5045 1514 6185 116092 94234 6615 6184 5315 10009 6935 93986 55810 687 9839 348262 746 1520 387893 1603 9069 81607 7841 5818 57863 137075 24146 9073 9071 9074 9075 84552 23705 1488 9080 1487 53842 7297 1010 1008 1007 1006 283 1005 1004 1366 1365 1001 1364 1016 1015 90701 1012 51208 64403 49861 221935 80332 23562 253559 149461 26285 92359 80149 54549 25945 3572 8728 28513 5010 3703 10686 3716 6597 50855 1650 26508 23478 5931 94239 84612 5589 9076 3728 50649 1000 23193 10207 54145 1013 1002 3170 8331 8337 7750 8334 8335 1003 8341 8342 8347 8348 8345 8340 8338 7122 9314 85236 8349 331 60559 998 54737 329 7088 23028 57531 8370 2146 6663 51129 3717 3013 84231 11171 255626 5584 1495 3021 1460 7414 3018 1785 1459 3224 3017 3609 1457 2294 3014 27319 28972 56978 8289 127544 474382 6929 8970 6714 128312 55766 9844 8726 8968 6938 23411 1793 7764 5879 29954 3570 10585 7490 3066 3065 653604 23512 4609 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism 148811 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 10642 10644 10643 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer 4088 4089 7046 7040 7048 4087 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria 435 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription 3280 84441 9794 2033 2208 3516 55534 388585 4853 10046 3002 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function 7516 7156 5892 5889 4683 79728 580 641 10524 7486 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 10635 5890 9156 675 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation 7450 5908 22866 6714 7094 409 2335 28956 369 408 10256 3674 283455 4140 54756 84292 2266 7414 3690 5037 2243 54518 7529 673 8826 5906 5594 5595 1445 8649 4893 5604 5605 3265 5894 2244 8844 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis 197258 7264 8790 55343 2762 282969 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 2247 2264 2251 9965 152831 4893 6654 2254 8074 2249 3265 2246 8823 8817 26281 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses 57369 56666 24145 84694 10052 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases 5340 1215 4323 4324 4325 10893 4326 7177 64386 4320 1504 5045 4322 1513 1511 80781 3817 4312 3818 5644 4313 1991 5645 1515 4314 4316 4317 7077 4318 50859 4319 7076 440387 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions 4128 4129 196743 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 27338 119504 246184 51434 51433 991 7321 25906 11065 8697 7324 10393 29945 29882 996 51343 51529 8881 8556 64682 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing 6844 5034 23265 5873 60412 54536 64924 57393 10640 5122 11336 3800 25924 149371 3630 6804 1363 3798 3799 55763 169026 55770 5126 56605 4644 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 5002 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 64924 169026 7779 7781 7780 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 192669 23112 27327 26523 27161 192670 57690 5728 4343 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 9154 292 55315 2030 293 23568 402 222962 291 3177 64078 9153 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin 9021 6774 3717 8660 3952 6777 3667 5781 6776 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 7316 5295 1950 2549 5335 6464 1956 7311 5290 7314 6233 3320 4893 6654 3265 11140 867 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation 3043 3040 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity 6091 9353 4650 387 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine 339896 1491 2806 1468 1036 100131187 51380 6821 23474 25828 84890 58472 4357 2326 7263 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response 10808 27000 259217 116835 7266 51182 573 3337 6767 51501 57805 23165 9531 22824 6782 3310 91582 3305 9631 9529 7175 10049 9261 3308 3312 3309 8021 472 545 348995 9883 57122 3304 6117 6119 6118 55746 3306 7531 23279 79023 10762 9532 6396 9530 23411 129401 4927 3313 5903 9688 23225 5594 5595 3297 55706 23636 9972 11097 23511 8086 53371 8480 2932 79902 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 7534 857 7532 2033 7531 6667 7533 10971 7529 4088 4089 2810 7329 5170 5706 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 5286 30849 200576 66036 5289 9108 9896 4534 55697 8898 9110 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK 5578 1956 4314 5594 887 5595 4893 2520 6654 1839 6197 3265 6196 5598 6195 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine 116285 348158 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism 8789 26330 5210 5211 5213 2023 92579 5091 10007 54020 23165 132789 9631 7175 5207 5208 2027 2026 669 5209 83440 5223 5224 8021 5214 5230 5232 2597 5519 348995 9883 387712 5515 57122 5516 5528 7167 2203 55746 23279 79023 57818 10762 6396 129401 4927 2821 2646 2538 2645 5567 5568 5518 80201 3099 3098 2542 5903 5105 9688 5106 23225 3101 226 55706 229 23636 9972 11097 5566 23511 8086 230 283209 53371 8480 79902 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) 3373 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy 57617 27072 55823 11311 7284 7405 26276 65082 81631 64601 23339 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates 4056 2948 CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization 5928 5929 10445 595 64919 55274 23350 80349 10946 4790 10419 83443 5970 10498 10524 1499 80205 29117 64769 1386 27154 84289 7862 56950 6187 7994 387893 6632 23774 6628 6634 6633 6636 29943 10262 6635 22992 84444 79084 6637 57634 27097 55693 53335 55578 84678 51412 9767 7468 10196 9643 54496 51780 83933 54014 353238 55352 5105 23030 3276 10765 64754 117143 10856 11143 6944 5978 8464 55929 93624 6595 23133 9879 23135 4297 55250 6597 80314 55257 6599 10629 6598 55818 11240 26610 55683 317772 23587 6907 9682 57504 55140 55689 83852 8648 85235 1106 54859 5931 79918 9739 8242 51111 54623 23326 84844 23569 94239 55167 10933 9070 64324 23210 1107 55170 23338 10943 8175 9869 56943 84159 84864 6749 9913 23506 65980 55869 1108 51147 29998 6881 51702 6880 55193 8284 6883 25855 221613 55870 23522 8295 23081 54556 54934 56970 92815 9757 8969 54815 56979 4791 8607 84193 11198 440689 79960 54145 10902 79723 196528 7404 6314 29072 53615 339287 58508 84787 8520 8331 8089 8337 5253 8334 63976 8335 221656 5926 5927 80854 1810 80853 51562 54904 8518 5977 51639 23168 8341 8342 8347 8348 1728 4780 8345 7975 8340 79685 6839 1387 60 10291 8338 605 5077 8473 8110 79595 57325 10285 84148 85236 27123 6601 8349 6603 6602 6605 6604 9575 1665 10284 84991 64426 79577 7182 23028 51230 57459 123169 8313 86 6871 7341 2033 26039 8370 10362 51317 2146 79813 22827 284058 9219 10499 55729 6760 9112 3717 7329 3013 11325 8819 23451 6925 8932 255626 3021 4654 4656 3018 3017 3014 10474 79718 121536 23186 9646 8289 8099 26038 8841 474382 114825 125997 2203 55205 6929 6941 10919 22806 57492 1019 22807 57592 11335 23613 10263 8970 170394 8850 9640 128312 7026 22850 85509 10951 23394 10320 152485 55766 84295 8726 8968 6938 3054 10992 26009 9274 9275 10523 84181 1788 57680 2538 3481 2874 85409 79843 55636 7403 10664 2122 23067 8193 3066 6627 3065 6629 112869 653604 23450 51742 84661 6638 2648 11091 9612 9611 23512 8085 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 344 9619 345 335 1071 348 9388 213 3931 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 55846 23677 81929 57600 155066 9114 11133 64223 8649 523 525 526 527 528 529 64121 10641 10542 83667 127124 51382 389541 533 28956 534 10670 57521 23334 153129 6009 6396 10325 652968 51606 245972 79726 245973 54468 55004 84219 9550 96459 154743 9681 8131 27244 2475 8992 90423 144577 58528 10312 201163 9296 729438 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 51082 4784 2972 2971 4774 6908 9328 9329 5451 10302 55290 55814 5440 5441 6621 6619 7702 6618 6617 9533 51728 27297 661 10623 171568 84265 5434 55703 5435 5437 55718 11128 10622 10621 112495 4781 9330 4782 2976 6741 2975 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling 5567 11069 6494 5908 5568 23108 7534 5909 7529 10411 5906 5566 10235 10125 5894 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system 103 7422 5657 729230 4939 8784 920 6810 3934 9861 5682 5683 5684 5685 5686 5717 5718 5719 11047 10213 5713 5714 7979 7291 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 3726 5702 5704 5705 3977 5580 9261 3312 7184 7534 8741 8021 1981 207 1432 3304 5600 3562 3578 3559 3581 3558 9978 25939 5775 4893 3265 5293 23165 9631 7175 7525 6175 7323 348995 9883 57122 1234 55746 6921 6923 23279 79023 10762 4088 6396 129401 3836 4092 4927 5903 9688 23225 55706 23636 9972 11097 23511 6097 8086 53371 8480 79902 4904 8600 1437 9246 64135 22926 3551 23586 25820 51191 9451 2537 10964 1147 2289 8517 9636 7318 3309 3429 7706 2162 5519 5525 5515 5516 5528 5610 3306 4582 5778 2625 146433 139716 2247 5795 5743 3688 5611 3561 4609 3718 5724 6616 5777 5295 3091 5296 5783 5290 5291 3437 3434 3667 3433 5803 595 7040 3845 240 7321 4790 7324 1436 301 5970 3162 3569 5336 6230 6232 6231 8575 6234 6895 6235 6227 6229 8767 6228 57506 4985 7334 7335 8678 3661 3654 3656 2357 6382 5894 821 3665 3442 3441 3440 3439 3055 6850 2209 3452 3451 3449 2534 3448 29110 3446 3445 3444 84166 92610 3443 51135 10392 4615 79671 84818 3456 246330 3454 9097 51447 3146 6285 6288 11274 6283 9683 6188 9684 6187 4793 6189 28512 57161 57162 177 23118 6935 121457 28511 2810 80216 3107 3106 3105 5781 9402 6191 6193 6192 6194 7297 6885 3134 3133 3921 7187 7189 6773 6772 3135 9466 1439 9244 1438 3572 246778 10148 10000 2197 23765 3716 8651 8660 140032 1154 3838 2690 5618 2689 6672 2688 1442 10454 8835 5617 6201 2317 6203 6202 64127 1489 3664 3669 567 10612 55128 59307 11213 208 5896 5897 51127 85363 3605 6210 4599 112744 23529 9830 51065 6205 55540 6204 6207 6206 6209 5008 6208 6223 79097 6222 4791 11074 6224 257397 26525 11009 9470 6218 6217 50604 351 84867 84868 386653 834 23087 64806 26469 4600 55223 6809 3082 27189 5908 6813 27179 27177 27178 6950 8764 4692 10379 85480 9616 4215 7726 64109 84174 115362 4261 23650 10346 6657 4281 54920 8638 199990 2175 55120 4734 53833 53832 2189 10019 53840 91442 201626 2188 998 11141 2187 80233 201254 57697 6041 2178 6059 282617 282618 282616 54739 3660 80128 6351 3659 6352 6356 6347 6349 9180 81603 6364 54472 829 6363 10410 6367 1230 3430 2919 1271 1270 3717 8877 117854 23321 6503 2920 7850 10475 3576 163702 5229 25930 3627 24138 3725 3609 7006 6737 80263 84639 5598 2635 3965 9021 388646 3976 133396 56300 200081 1027 26095 91543 58985 132014 3563 1398 3560 1965 3557 3574 8894 3568 1968 5770 3575 5771 867 3590 3589 4843 3588 3181 5780 9987 6775 5784 8808 3185 5062 3123 8809 3936 3122 3598 654483 3120 3597 3458 6624 5898 3119 8807 6845 3118 3117 6647 3115 6627 3113 6648 4282 5055 10581 4001 3595 10107 3594 9039 3593 3127 3592 3126 1072 3125 27250 8065 302 3586 29949 1265 9040 5721 116379 5696 4478 5306 55801 10068 3603 4938 3601 3600 3608 1440 4940 1441 8563 9775 51231 1849 1848 1846 1845 7186 5971 356 841 959 7322 3689 4869 59067 4067 4792 5608 2353 3383 3394 115650 7412 1026 2889 10437 1386 5594 10673 5595 1399 5604 604 6654 79792 5034 5300 3305 3635 3636 2176 8878 2322 4507 3552 3553 9020 3606 8771 4055 4050 1896 4049 8740 7133 8744 4982 8742 7293 332 7292 3604 60401 51330 23495 608 8792 1974 5371 1973 128178 8995 970 1977 10913 939 943 944 9966 8718 54014 51561 149233 5443 4128 4502 8503 3929 7341 246 8554 6095 2316 7329 5478 7157 9446 6714 4690 6464 2208 50615 2185 6655 9655 9306 2887 3459 3460 9049 5335 8454 6233 7409 3320 8662 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 10480 7316 1964 7431 23291 6804 8945 5518 7311 7314 6500 3313 27 983 5566 10018 596 598 6844 6774 6868 3911 79923 8519 2323 759 5045 941 942 1958 1511 6622 90865 71 9173 9846 7076 6888 836 2342 2339 2335 960 317649 1052 9235 684 5495 4312 4170 4313 4314 1901 4318 6597 3932 3663 3684 1982 378708 50616 2885 58480 948 1445 375 115361 7124 10538 6348 163351 3567 3566 3565 4684 3662 8672 5451 60 3596 6777 6776 6778 29760 330 1660 7132 3839 3840 3841 329 2939 1435 6197 6196 6195 4205 4208 79155 2002 5599 9252 1326 5609 466 6416 5601 7867 5602 5606 3837 2309 2308 5292 815 816 4988 817 818 2634 2633 402569 8968 3687 3554 3570 3587 5782 1278 653604 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation 2686 2940 2949 10327 124975 2948 2947 2946 373156 2954 2953 27306 2952 2950 26873 119391 79017 2729 494143 653689 221357 4257 4258 2730 4259 2678 2098 55748 2939 79094 2938 2937 9446 2944 2687 2941 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation 146850 5293 8503 5294 5295 23533 5296 5290 5291 23308 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion 2157 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors 1132 1133 1129 1131 1128 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development 22794 9939 65109 9775 1739 10921 55110 4116 7430 4627 7220 7222 7224 7223 25937 7225 5962 4651 4664 4665 1959 57113 1272 7003 6712 4067 5588 8851 9861 7074 5682 5683 5684 5685 5686 5717 5718 5719 11047 10213 5713 5714 7979 5690 5594 5691 5595 5692 5604 5605 5693 6654 5694 5695 2043 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 219699 8633 3312 1630 9423 90249 137970 5578 140801 1981 6586 4753 26986 8650 7903 9978 91584 286 5576 27255 3673 8515 10752 5567 5568 6122 6124 6123 6125 6721 6130 6133 6132 1605 6135 4893 6134 6137 1741 6136 51121 3265 6128 6129 5921 6142 6141 6144 22916 6143 6146 8861 6147 5293 6139 4686 6138 2902 6152 6155 6154 7525 6157 27330 6156 6159 6158 6164 6166 6165 7852 6168 6167 6169 23521 6160 6161 6175 6176 6171 6170 6173 6921 6181 6923 8912 79966 8976 6093 2904 8503 1969 5664 6663 5454 1463 55851 83464 64283 4628 4629 57522 6456 1175 160 1460 79784 3685 161 163 26052 3690 1785 1459 1213 1211 1457 1759 4637 51107 4650 6709 27289 6711 5747 6714 9037 6387 6092 2668 4690 5979 116832 9353 9046 6464 23767 2674 3688 9901 9495 4099 5295 5296 10818 5290 5291 6655 10451 2887 200916 5216 5217 9355 9045 8022 23053 23708 7410 6091 5335 26019 56956 2064 3670 1956 10109 23032 2107 9826 89884 65110 4440 6585 6233 3199 1287 3320 5361 2935 5364 6453 8997 8874 10552 7316 9855 5453 80728 256076 23332 6230 6232 6231 6234 6235 10093 6227 10092 6229 10095 6228 10094 7204 10097 1595 10096 1286 1285 1284 1282 288 7311 7314 27 131873 1293 1292 6383 1291 23380 5566 8440 5058 28964 388 389 5663 5063 23122 23365 3915 1299 1298 23129 23396 2534 3326 3912 10298 11224 25791 25873 6188 6187 6189 23385 51466 71 9846 10398 6386 2817 775 10048 776 5781 9349 6191 6193 7305 6192 6194 54209 783 784 56924 3921 9475 1297 8829 102 4313 1742 4318 2197 8660 140032 6597 6201 1212 6203 6202 57144 10570 375790 10371 56896 2242 6210 57556 10507 5532 6237 5788 51065 25 80031 5362 5365 6205 9723 6204 8218 64218 6207 971 6206 6209 10154 3672 6208 6223 1809 6222 8482 1400 6224 1808 55558 2886 6218 6217 4756 782 785 3984 3985 103910 1020 4233 2549 6478 9048 779 6477 6900 64096 4902 4684 2675 5621 8913 5623 8911 60 24137 998 284217 22885 2676 3897 285220 2932 3785 30011 3786 3680 6708 10627 100133941 2596 6710 4897 8453 148738 57453 57698 5649 2045 2044 2042 2041 5786 116986 2051 2050 2049 2048 2047 2046 8828 56963 10486 84059 10487 4359 8986 8128 6324 6323 57716 6197 53358 4155 6196 11313 6195 6331 6330 6332 6335 6334 214 9252 6326 8506 6328 285643 6327 6329 57731 6336 84448 7436 11280 59277 220164 55800 1943 287 1942 51332 10413 1949 1948 1826 1947 1946 55816 1945 5598 1944 85358 23114 2909 1600 55715 1641 9260 284656 5909 285704 3983 7094 57211 1796 3156 1821 1793 5879 387 5376 3908 3674 3678 5062 55740 3066 7402 1072 7408 4478 4736 5306 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes 51706 759 606495 3043 51167 51700 760 762 6005 3040 358 6521 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system 5959 5956 9227 7276 24 5947 145226 6017 611 64220 2652 222236 5950 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling 3659 3665 3442 3441 5777 3440 3439 3437 3664 3434 10410 3669 3433 4938 103 3430 3452 3451 3449 4940 3448 3446 3445 4599 2537 3444 8519 3443 9636 3456 51447 3454 3429 11274 1958 24138 6233 3837 4939 3107 3106 3105 4600 5781 7316 9021 5610 2634 25939 10379 7297 91543 3662 3134 3133 3836 5770 6773 6772 8638 3135 684 3661 7311 3394 7314 10581 6041 6059 54739 8651 3716 3660 5696 3663 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation 135 116 4914 117 4915 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation 8074 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication 8341 8342 23633 8970 8347 8370 8348 128312 8345 94239 8340 55766 8968 3013 8338 3836 255626 3021 85236 8349 3018 3017 54145 3014 653604 3837 8331 8337 5000 8334 5001 8335 23595 23594 4998 4999 474382 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling 640 5079 861 1998 1997 865 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids 9968 9969 2583 2581 81616 80777 3422 4758 4759 91452 339221 123264 55361 10858 215 2101 80306 284486 66036 5641 145482 866 5660 51360 873 10498 2166 116519 405 406 142827 2173 2172 2171 23305 2170 54893 410 412 2169 2168 414 415 416 54898 8705 8706 10478 25979 4363 8720 3033 5096 81849 81846 253782 31 3638 8714 32 5095 56898 1455 427 11332 340485 9261 3631 3635 3636 10654 29095 10005 6555 6554 5825 285362 27063 56623 56624 57761 55588 5244 64064 55300 4520 55304 81857 55301 151742 171546 6584 158584 80724 10449 6579 6720 6718 5264 6713 8776 4534 5867 51763 6715 5868 5567 53947 5568 126282 6716 6721 414149 30815 8310 376497 5286 5287 622 11283 5288 51302 3248 8309 5294 6770 4594 5297 5443 4597 5298 5444 1081 51141 5293 51144 84693 6785 660 55512 4598 5445 5446 56848 65977 3284 3283 54677 50486 9200 65985 6305 57704 6307 6309 150379 3291 1718 3290 1717 5476 128486 9217 123099 3295 23533 3294 55711 3293 51171 3292 51170 55289 27242 51179 79966 390916 9218 5467 641371 10226 112950 79993 10825 80230 8396 211 375775 213 8394 8395 3930 8503 51703 345275 9256 6342 5901 57491 5499 57733 221 222 10682 5007 166785 64834 231 116255 4800 4801 239 4802 5019 130367 8529 8540 7376 112937 3074 124976 3073 241 242 6256 80270 79411 7421 246 411 5465 247 4199 2720 2638 9885 165679 89944 6095 29841 51588 5468 3972 7329 3992 6613 9415 9412 9896 8560 1892 51552 347527 9420 8895 9468 26279 1460 10809 590 23446 126969 1459 117145 201164 1457 84002 81579 161247 2820 55326 56894 2678 57104 56895 51365 54600 11343 51573 6901 51099 9429 253558 158835 9441 22925 200879 56261 10998 63874 64419 2687 64600 51102 57110 51586 204962 11001 27132 83930 23171 11000 1103 79887 4862 248 5730 23175 1374 255189 254531 79888 646486 283871 5728 30814 9453 10423 153642 8398 11010 8399 284541 64850 5740 5320 2232 5321 1384 9489 2230 5322 646480 255043 1120 1962 9362 283748 2224 80821 84498 1376 55500 114971 57664 55224 5833 1375 2222 5319 1119 201562 8443 64900 3032 3030 7296 79143 55750 100137049 134526 149998 58526 122618 10400 5742 54947 5743 154141 7923 9926 4899 43 9663 374986 22937 8694 6610 129642 340075 23760 6609 23761 162466 28234 23646 84803 84869 84649 22949 54675 347516 346606 26063 8605 51205 10965 5337 11145 5338 81490 83394 23659 400569 57153 9791 122970 23259 57678 26061 5295 84879 9023 58488 150763 5296 113612 5783 26119 50640 2274 5290 50487 401494 5291 151056 10390 137964 9600 114884 54511 80736 80339 55090 1040 64801 56910 117245 56994 2877 10554 57605 2876 10555 1545 8904 54979 5130 1543 8760 23097 10162 114879 123745 8821 171586 2879 1558 1544 84895 1576 114882 51495 85465 1565 2819 79071 1571 55856 2053 5920 5305 240 284161 1557 1559 219541 79837 10599 1583 1582 1581 200931 1580 3155 23600 54545 1579 1573 1594 1593 1591 3158 3157 1589 6667 1588 79642 1586 79644 1585 1584 55697 5500 8871 1109 4036 64174 570 125981 6483 147323 10558 1595 9871 6487 9632 204219 8869 8867 10427 4047 706 126410 5289 80205 8879 4051 8897 6822 8898 4056 1149 5501 84320 4048 5566 133121 6837 29956 80221 10715 4074 50814 6257 29923 23389 114876 388121 81537 81544 253017 51422 114880 441282 114881 1800 23396 114883 10728 7108 23683 29906 25865 23205 5538 197322 857 10062 25870 6296 55825 55613 9334 9331 166929 64781 5563 183 5565 200576 392636 51478 91012 55627 84188 196 9915 26031 84725 51128 22908 788 8029 7179 2713 8611 2712 8612 2710 5587 10948 54797 2717 27349 10908 112812 22901 57834 26027 79603 9374 8613 10802 83401 10484 9862 335 336 2760 9971 25816 6907 8644 259230 30849 8648 59339 10891 59338 94103 79626 96764 91734 9967 22880 59344 94101 123 27306 23054 283927 60481 142891 8647 9514 19 23179 4952 8202 9524 948 375 377 9517 30 33 34 84246 35 37 38 9536 39 7357 47 1024 7368 1387 84129 9443 9442 9440 2629 85441 109703458 127281 9439 6604 8228 9575 23597 9572 90809 9107 146850 27124 2033 51003 2948 120227 8800 158833 10499 9110 51129 9477 1622 388931 90390 8877 9108 79153 79152 10025 1632 7069 80142 63924 892 134429 1646 1645 2167 403313 80168 3837 79718 26230 1666 2180 8841 93492 4706 10001 2524 2523 25942 79611 2531 29079 2874 5346 22874 22876 5469 6319 133522 79777 80765 2194 9282 54477 2182 2181 6916 55331 9612 3991 9611 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions 204962 57153 116085 53919 6576 28231 11309 6567 284111 9058 9356 159963 682 64849 80736 26503 6579 345274 9194 60482 133418 9123 353189 8402 6566 1468 23539 23446 126969 6578 160728 10599 28234 551 9376 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs 2322 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD 27248 7316 5687 5688 5689 5700 5701 6469 5702 5704 5705 10956 84447 51009 9861 7415 5682 5683 5684 5685 5686 6400 5717 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis 5111 10714 5424 57804 23649 5981 5422 5984 5985 5557 5558 5425 5982 5983 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport 90550 7417 8165 91689 7419 6687 5245 9512 10939 23203 55486 7416 55013 79568 221154 11331 30968 10367 10730 286097 6547 80024 3954 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway 8431 7101 3164 6257 7376 7068 5241 6256 6258 7421 5465 2099 7181 2100 6095 367 4929 5915 5916 5467 126382 3174 5468 7025 5914 2516 2104 2103 5469 2101 9975 3172 9572 2063 6097 9612 7067 7182 6096 9611 29959 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria 5053 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o 54344 8813 8818 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 55683 5929 6871 55689 8850 10445 9739 29915 284058 9070 79447 23054 4221 3054 26009 22976 259282 8473 55617 57325 7403 54934 84148 11168 9757 91272 23067 51105 112869 10474 84661 58508 2648 11091 4297 30827 1810 51562 51230 26993 8085 80335 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis 51363 1463 1462 10675 29940 1634 92126 113189 63827 10090 633 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway 5423 328 7515 3980 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation 9212 23421 51143 25909 9183 401541 54821 9184 64105 23122 991 4085 701 378708 1780 79172 81930 84643 55920 3796 27436 57405 7514 1783 83540 80152 10403 8655 3619 80776 64946 1781 11243 5519 1778 348995 5525 5515 91754 5526 140609 57122 5516 10783 5527 699 11004 5528 5529 91687 57551 140735 55746 79682 11130 25936 9793 332 23332 6232 23279 79980 2491 79023 55839 54908 8379 5347 55143 22919 6396 55166 5048 10726 79019 151246 1063 9735 1060 151648 5905 5518 1062 1058 5903 79003 55055 220134 81565 57082 54820 5501 6249 147841 79902 348235 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly 5034 338 4547 344 345 335 336 348 51128 337 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 2247 4893 6654 2254 8074 2249 2246 3265 8823 8817 26281 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs 7316 317772 84142 9577 79184 2033 114548 85235 8850 114803 10617 23172 580 57559 3013 8338 221613 92815 8969 8027 7311 7314 10213 6233 8331 8337 8334 672 8335 29086 51720 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis 2302 4851 10309 124093 5990 5991 647309 159989 7161 4343 192669 23112 27327 29841 26523 345643 27161 192670 57690 57822 79977 1874 4602 28514 7027 51053 1875 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism 51302 11001 9971 1593 8644 8309 3295 9023 26031 8648 6256 80270 114876 9885 10499 114880 114881 1109 8714 114883 6579 570 6718 8647 123264 213 10005 9420 6555 6554 10858 2172 80765 5825 1646 1645 10599 28234 5007 1582 1581 200931 23600 10998 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions 5928 5925 4613 4343 192669 23112 27327 26523 27161 192670 57690 1009 9789 7410 7020 6233 27085 4790 1500 79872 10399 2060 117581 5970 7316 3569 6667 9855 5817 5819 4193 9743 9861 7074 5682 5683 5684 5685 283106 5686 5046 9159 5717 288 5718 5719 1499 7311 7314 11047 10213 5713 5714 7979 7291 5690 5594 5691 5595 5692 5693 5694 5695 5706 5707 58505 54971 5708 5709 821 5687 5688 5689 6774 5700 5701 60436 5702 5704 5705 100128731 999 23396 6591 1508 5045 1514 6185 116092 94234 6615 6184 5315 10009 6935 93986 55810 687 9839 348262 746 1520 387893 1603 81607 7841 5818 57863 23705 1488 1487 7297 1010 1008 1007 1006 283 1005 1004 1001 1016 1015 90701 1012 64403 80332 253559 80149 25945 3572 8728 28513 3703 3716 6597 1650 26508 23478 5931 94239 5589 3728 50649 1000 23193 54145 1013 1002 3170 8331 8337 7750 8334 8335 1003 8341 8342 8347 8348 8345 8340 8338 9314 85236 8349 331 60559 998 54737 329 7088 23028 57531 8370 2146 6663 51129 3717 3013 84231 11171 255626 1495 3021 1460 7414 3018 1785 1459 3224 3017 3609 1457 2294 3014 27319 28972 56978 8289 127544 474382 6929 8970 6714 128312 55766 9844 8726 8968 6938 23411 1793 7764 5879 29954 3570 10585 7490 3066 3065 653604 23512 4609 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 79646 79717 60490 80025 80347 53354 79877 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 29126 5687 5688 5689 5700 5701 6048 5702 91445 5704 5705 10956 51422 51009 5562 5564 7415 6400 5571 91319 6233 5563 5565 27248 7316 10613 11160 9861 5682 5683 5684 5685 5686 79139 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 53632 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 5687 5688 5689 6932 5700 5701 5702 5704 5705 166 8454 6233 8312 23401 5519 324 10023 5525 5515 5526 5516 5527 5528 139285 5529 7316 1452 6934 9978 1488 1487 9861 83439 5682 5683 5684 8945 5685 5686 5717 5518 5718 5719 1499 7311 7314 11047 6500 10213 54764 3065 5713 5714 7979 5690 5691 5692 5693 7088 5694 7089 5695 5706 5707 2932 7091 7090 5708 5709 51176 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) 1616 546 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT 3815 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events 111 112 59345 113 114 115 2793 2792 2771 2791 2790 2770 2782 2788 5999 346562 8601 2787 2781 2786 196883 26575 2785 5588 5582 2784 5580 2773 2783 10681 51764 2778 150 152 107 10287 5579 108 5578 109 94235 6004 353299 151 55970 5581 5583 54331 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 10682 6309 1718 1717 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors 10800 56413 1241 2840 57105 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol 3707 23236 27124 5336 9651 5728 89869 80271 113026 3633 8867 3635 3636 4952 5335 122618 23007 51196 808 5330 5331 5332 5333 84812 3705 3706 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity 7316 3082 5795 6457 4233 6456 8027 7311 7314 10254 6233 26018 2060 9101 5770 9146 6455 30011 5771 867 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation 126 216 127 217 128 55902 219 84532 130 131 124 125 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions 57453 1826 1630 9423 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking 57120 23433 1080 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins 111 112 59345 113 114 115 360 361 2793 2792 2791 2790 358 2782 359 2788 2787 2786 196883 2785 2784 5573 2783 5575 10681 51764 5576 2778 107 108 5567 109 5568 94235 8766 55970 5566 551 4645 554 22841 5577 54331 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins 5645 1668 920 1671 728358 1670 5646 1669 417 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination 4968 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 26277 25913 65057 7013 3013 8338 7014 54386 255626 55247 85236 8349 4350 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway 3665 3456 80143 7706 9641 2033 3661 84282 64135 1387 57506 23586 29110 7187 89122 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants 4893 4763 3265 399473 161742 200734 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 121260 3551 1147 80231 8517 3663 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) 5295 5335 6714 5802 5290 3667 25920 5800 581 4893 6654 4916 3265 4908 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin 5294 5295 23533 2549 2057 5335 5336 6464 2056 5290 5291 2889 7409 5293 4067 1399 4893 3717 6654 8660 3265 6777 6776 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII 5295 1950 2549 5335 6464 1956 5290 3320 4893 6654 3265 11140 867 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network 2803 4074 8674 57589 4905 51209 10139 60592 84316 5870 400 8677 339122 51542 7110 10244 23647 79571 9382 9712 90196 122830 22836 60560 6293 2800 9648 738 8775 55275 8675 3482 22796 143187 10618 51560 84342 91949 25839 10228 83548 57511 10466 9341 10226 8774 9827 63908 9367 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling 7316 56937 57154 23327 4087 9110 5500 4088 51377 64750 4092 7040 11171 7514 23645 10273 7311 7314 5499 25805 7046 7048 6233 9958 5501 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 83592 2548 5236 8908 5255 5256 178 5257 808 5261 2992 5834 5260 5836 5837 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 192669 23112 27327 26523 27161 192670 57690 266743 4343 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose 4351 29926 29925 5372 3098 5373 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity 1019 894 896 595 1021 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins 1509 1359 10159 1636 5972 1522 1215 1511 1361 2028 183 1066 59272 2999 4311 290 1360 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development 4094 10013 6714 5925 121340 23314 4086 3280 367 4089 9759 23493 4091 7525 25925 865 25 23462 2737 2736 10432 25937 1277 5594 5595 10413 3549 221044 632 8841 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry 7113 1514 59272 7415 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells 4825 3651 2255 3175 6928 390874 256297 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses 6511 6616 6506 6505 6532 6507 81539 9463 7102 2892 6512 2890 23426 6540 18 4905 140679 1739 7915 54407 5579 80852 2036 6529 2893 80331 64130 5330 5331 5577 4193 27163 10550 6804 27165 53632 5594 5595 5566 5170 6571 8541 8497 22999 8224 8499 8500 28964 10815 6854 6844 6853 5864 10497 6857 2891 51422 6582 6580 346562 57030 60482 2773 5562 6539 5564 3312 6538 5578 23229 5571 10645 5563 84254 5565 8536 773 777 111 112 113 114 115 783 784 196883 5573 5575 5576 107 108 5567 109 5568 88 3760 3761 2550 3759 3359 55327 200909 3772 1742 2562 2561 2560 2559 2558 2557 2556 4893 83988 2555 1741 2554 2744 1740 26960 3265 3838 3762 3763 3765 3766 3768 2570 2569 55584 2567 2566 3773 8825 4900 2752 4747 55879 9647 170572 2771 8573 2900 2743 2770 2742 2741 2906 2905 2902 2901 5582 285242 200959 22843 320 27330 116443 1146 1145 57554 1144 116444 9568 27020 89832 9177 8001 2899 2898 2897 2774 5923 808 781 782 4128 785 57576 55799 774 5924 59283 1138 1137 1136 1135 1134 23236 10369 8973 27092 1143 1142 1141 10368 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 2904 2903 217 9256 9254 94235 55970 54331 59345 2782 1312 6572 6531 10681 6197 6196 6195 160 590 220074 2572 4646 2571 3084 1103 814 815 816 5613 6714 817 818 5879 43 9495 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 7514 5045 23478 1460 5499 1459 60559 1457 5500 28972 3320 3837 5501 3326 9789 90701 3312 SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste 3759 133060 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P 22934 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 2646 2645 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P 22934 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 506 6907 8648 10891 6256 5465 96764 3418 10499 23054 55902 23373 4208 2101 808 79718 4209 64784 200186 8841 23408 23409 2551 56652 814 23410 7019 51106 6742 84808 11232 10498 1387 5442 54205 64216 3054 7978 23082 211 5469 85441 133522 80205 4899 6648 6604 1386 9572 2746 9611 2747 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape 5436 6908 4331 5438 5439 902 129685 6872 404672 6874 2071 6873 138474 2068 6881 6880 5430 6883 5431 6882 5432 5440 8148 5433 5441 6884 2966 2965 51616 6875 6878 83860 5434 6877 54457 5435 5437 2959 2958 6879 2968 2957 2967 1022 2963 2962 2961 2960 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs 3248 240 4048 246 5743 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 57698 8986 27330 6197 6196 6195 9252 6456 7430 1175 160 24137 285643 161 163 1808 26052 1785 1213 1211 1759 5962 5594 3897 8650 4478 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport 6710 51143 829 10652 11070 1780 2801 830 832 3630 84364 4905 26958 1783 51014 10945 966 23423 372 9570 57731 1604 381 8655 1781 9382 9276 81876 6811 287 10959 11316 51332 375 1778 377 22818 6709 1314 54732 51226 22820 8775 140735 1315 11014 22796 5861 6711 84342 91949 25839 378 51272 83548 57511 6712 9527 10466 10540 286 55738 8774 93661 2804 2348 10972 55860 8729 64689 288 1639 63908 51164 8615 84516 11015 10282 26286 10671 10121 11258 6708 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade 2812 7450 2815 2814 2153 2811 8460 2147 2266 8459 2243 196527 2677 2160 2159 2158 2157 5624 5627 2244 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization 3861 3866 3868 5266 404203 4014 26239 6707 84648 353132 353131 6700 643414 11187 6701 6704 643418 6703 3713 6706 6705 643394 63036 353134 43847 23254 353133 43849 64065 353135 7051 353137 353139 26085 126638 199834 353141 2312 149018 353140 353143 353142 1825 1824 1823 5046 6698 353145 353144 1041 7062 448835 1830 2125 23581 1475 142910 6768 5317 11005 11202 147409 5318 9333 5493 25818 5652 254910 6699 340654 5045 1829 823 826 3728 1832 8502 728279 3880 3881 286887 3882 353323 54474 81850 81851 1828 3872 3875 643812 140807 3890 3891 3892 353332 353333 3883 3884 3885 3886 3887 3888 3848 728299 162605 81870 81871 81872 390792 728224 100505753 440051 440050 728255 192666 25984 440021 100505724 100533177 338785 440023 100131902 643803 337979 337978 337977 337976 337975 196374 337969 337967 337966 337974 337973 337972 337971 337970 144501 337959 337963 337960 51350 728318 388818 84616 386684 386683 386685 374454 386680 386682 386681 386677 386679 386678 386672 386675 386674 100132476 100288323 83902 121391 83901 83900 387264 100507608 387273 254950 387266 387267 353288 125115 147183 85291 85290 85293 85294 85280 57830 85289 85285 337879 337882 337880 100132386 140258 8688 8689 8687 112802 83899 83895 83897 83896 9119 284827 653240 319101 3849 342574 3846 3860 3858 3859 3850 3851 3852 3853 3854 3855 3856 3857 439915 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds 51302 9971 8648 113612 196743 54996 5443 66002 8639 80777 1545 1543 13 1549 1548 1558 1544 1576 5447 9049 1565 1571 64816 54905 1557 1559 10858 1555 1553 1551 8824 670 26 1572 1562 1583 4128 4129 1582 1581 1580 1579 1577 1573 340665 1594 1593 1592 1591 1589 1588 1727 1585 1584 874 1595 405 216 217 218 219 126410 57491 4051 124 125 126 127 128 29785 8529 120227 6256 130 131 10499 55902 10728 3326 56603 64757 4835 9420 285440 2328 2327 23491 2326 2052 134147 196 9915 284541 5740 2232 2230 84532 314 112812 57834 5742 11283 1066 6916 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants 7450 5908 22866 815 816 6714 817 7094 409 818 2335 369 408 3717 10256 3674 283455 4140 2266 7414 3690 2243 54518 7529 673 8826 808 5906 5594 5595 1445 4893 5604 5605 3265 5894 2244 8844 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma 146850 59345 5294 23533 2793 2792 2791 2790 2782 2788 2787 2786 208 2785 2784 2783 10681 51764 387 94235 207 10000 55970 5170 54331 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation 5436 6921 4331 5438 6924 5439 6923 902 404672 22916 2071 7469 8178 2068 4686 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 2966 51497 2965 11198 25920 5434 5435 51224 5437 7936 2968 2967 1022 2963 2962 904 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators 78989 712 716 2220 1401 8547 10584 2219 4153 713 5648 714 715 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) 6507 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER 9554 374 375056 51128 10113 4253 3998 9871 5265 2890 9632 1075 2348 10175 10972 7039 10427 2153 966 254263 1522 9570 81562 149111 90411 10802 1294 6811 10959 79748 10484 10960 2157 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation 54516 9617 84340 4539 92399 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 54998 10573 11222 128308 51649 9553 64960 63875 64963 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 10102 56945 28998 64975 64976 79590 64979 54471 64978 91574 23107 28957 123263 4528 64928 219402 7818 51250 57129 115416 51263 29088 51021 54534 51023 51264 51069 84545 85476 5018 78988 122704 92259 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 51073 118487 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 4508 4509 4706 7284 4519 4512 4513 4514 4540 4541 4535 4536 4537 4538 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome 2874 808 6907 79718 814 5566 9612 25942 9611 8841 3065 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere 1616 546 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) 7316 9021 6921 6774 6923 3055 6850 7297 7322 9616 1440 4067 3717 1441 2885 6777 6776 3845 6772 6464 7311 7314 6233 7321 9846 7323 8065 8651 3716 5781 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation 3678 1088 3688 2335 634 4680 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 3417 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids 51302 9971 6907 8644 8309 57678 8648 9023 26119 6770 96764 5443 91734 4597 1081 51141 51144 64801 23054 3422 8647 4598 123264 79071 10858 3284 3283 10599 1583 1582 1581 6307 5641 200931 6309 3291 23600 1718 3290 1717 1594 1593 1591 3295 866 3157 1589 39 6667 3294 3293 1588 51171 3292 1586 51170 51360 79644 1585 1584 10498 1109 4036 1387 570 147323 9871 1595 9632 213 10427 4047 3930 706 85441 9256 5901 2172 80205 6604 10682 412 5007 231 4800 4801 4802 50814 120227 6256 8720 80270 7421 5465 114876 2638 9885 10499 114880 441282 31 114881 3638 32 8714 51588 114883 3972 7329 7108 6613 10654 10005 9420 6555 6554 5825 134429 1646 1645 403313 3837 79718 51478 10998 11001 83930 4520 26031 51128 9453 8029 2232 2230 6579 6720 10948 2224 6718 6713 2222 6715 6716 5469 112812 6319 80765 2194 6721 10802 22937 10484 28234 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins 9212 5687 5688 5689 5700 5701 9184 5702 991 5704 5925 26271 5705 890 8900 4085 701 9232 8556 6790 8454 6233 7321 25906 11065 8697 7324 6502 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 1017 51433 5347 4751 9861 5682 891 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 5058 59345 94235 2793 2792 2791 2790 2782 998 2788 2787 2786 55970 2785 2784 2783 10681 51764 9459 54331 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism 2806 2752 57494 27165 29920 284716 2746 65263 2744 883 5831 4942 2747 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines 10797 25902 10840 81034 113235 160428 2350 10588 6472 200895 4522 4524 441024 6470 1719 6573 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism 3251 100 353 4860 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 11081 4969 5549 4166 176 4060 2331 4958 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system 7316 7311 4360 7314 567 7097 6233 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 1836 10861 9061 284129 9060 51000 347734 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 1544 2053 1557 1559 1545 1543 1573 1558 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins 23421 51143 401541 64105 378708 1780 79172 286205 29984 5216 5217 1783 83540 80152 8655 3619 64946 1781 1778 348995 57122 699 140735 55746 25936 9793 23332 6232 23279 79980 79023 54908 5347 22919 6396 60 5048 151246 9735 5905 5518 1062 5903 998 220134 57082 54820 23380 5501 6249 79902 9212 388 25909 389 9183 54821 9184 991 23122 23002 4085 701 81930 84643 55920 3796 57405 7514 10403 81624 80776 11243 5519 51466 71 5525 5515 5526 5516 5527 114793 11004 5528 5529 91687 57551 79682 11130 1729 332 2491 55839 8379 55143 91010 1855 6722 5879 55166 10726 387 79019 1857 1856 1063 1060 151648 752 1058 57591 79003 55055 81565 3688 147841 348235 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes 9662 8655 7840 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1454 1453 55125 5577 9814 9738 11190 9793 7532 7531 10383 10382 23332 115106 79441 95681 1069 5347 22919 54801 10142 7846 9702 10540 5108 11116 4751 5048 55142 22897 54930 5116 79959 80184 5518 93323 728642 7277 984 23354 22981 8481 114791 80254 85378 983 10426 121441 27175 55755 653784 54820 29922 10806 27229 440145 10121 10844 5566 55835 80097 55559 8636 11258 84131 4957 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 91603 10714 4331 51426 50813 5424 9716 57804 902 2067 404672 10920 1642 54107 7507 1161 5430 5431 10450 5432 2873 5440 5433 5441 6917 2966 2965 7874 6233 5434 5435 27339 5437 56949 2968 2967 1022 9318 57461 6117 7316 5111 6119 5436 6118 5438 5439 2074 9978 2071 8178 2068 57654 5982 5983 7311 7314 8451 5981 8533 8450 2073 2072 64708 56655 5984 3978 5985 7515 10987 51138 5425 5426 10980 5427 3980 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 8644 5948 338 51109 83875 344 9227 345 348 151056 338328 7276 29967 221914 9672 4035 1109 4036 2239 5947 4023 375790 2719 54884 3339 1208 53630 2262 1645 26020 3949 6383 10082 57016 7804 6385 5406 55937 335 6382 336 337 2817 5950 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations 10585 84197 2218 10329 10559 9486 79147 11041 84892 9215 113829 55624 729920 1605 120071 148789 29954 146664 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle 5058 28964 6510 5295 5296 653361 116984 10652 50508 392 3998 10006 395 397 1536 1535 10458 10424 10787 9815 10298 23092 143098 4983 347902 4952 4810 857 7410 1829 9710 22865 10152 64411 81624 23344 55114 23191 23075 51347 124056 10979 7037 8987 2909 55914 10163 3071 4162 4168 11135 80728 5881 2010 8773 7444 9341 57580 613 7204 9743 57584 10811 26050 394 7074 27035 7879 9235 3930 55843 55789 5062 55004 81839 182 4688 143872 55845 27 4689 998 29 2889 55971 23592 23380 1969 3688 55619 85360 8936 7112 29127 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL 1857 8395 1856 1855 1460 1454 1459 1457 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis 7157 1029 831 7531 356 3725 6648 351 993 4001 994 995 84290 5052 2309 708 2801 1020 823 8851 824 7001 826 10018 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 4049 8740 7186 8742 330 115650 51330 8600 8792 959 10673 329 9020 7187 4055 4050 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 1616 546 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production 6610 10399 7124 55512 8439 7132 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway 6885 7316 80216 10454 7311 257397 7314 92610 7189 6233 23118 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization 5928 5925 4613 4343 192669 23112 27327 26523 27161 192670 57690 1009 9789 7410 7020 6233 27085 4790 1500 79872 10399 2060 117581 5970 7316 3569 6667 9855 5817 5819 64398 4193 5339 3691 9743 9861 7074 5682 5683 5684 5685 283106 5686 5046 9159 5717 288 5718 977 5719 3655 1499 7311 7314 11047 10213 5713 5714 7979 7291 5690 5594 5691 5595 5692 5693 5694 5695 5706 5707 58505 54971 5708 5709 821 5687 5688 5689 6774 5700 5701 50848 60436 5702 3914 5704 56288 5705 100128731 3918 999 23396 6591 1508 5045 1514 6185 116092 94234 6615 6184 5315 10009 6935 93986 55810 687 9839 348262 746 1520 387893 1603 3611 9459 55742 9069 81607 7841 5818 57863 137075 24146 9073 9071 9074 9075 84552 2318 6251 23705 1488 9080 1487 53842 7297 1010 87 1008 1007 1006 283 1005 1004 1308 1366 1365 1001 1364 1016 1015 90701 1012 51208 7016 64403 49861 221935 80332 23562 29780 54751 253559 149461 26285 92359 3909 80149 54549 25945 3572 8728 28513 5010 55679 3703 10686 3987 3716 6597 50855 1650 26508 23478 5931 94239 84612 5589 9076 3728 50649 1000 23193 10207 54145 1013 1002 3170 8331 8337 7750 8334 8335 1003 8341 8342 8347 8348 8345 8340 8338 7122 9314 85236 8349 331 60559 998 54737 667 329 7088 23028 57531 8370 2146 6663 51129 2316 3717 3013 84231 11171 255626 5584 1495 3021 1460 7414 3018 1785 1459 3224 3017 3609 1457 2294 3014 27319 28972 56978 10979 8289 127544 474382 6929 8970 6714 128312 5829 55766 9844 8726 8968 6938 23411 1793 7764 5879 29954 3570 10585 7490 3066 3065 653604 7408 3688 23512 4609 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters 1836 65010 5172 115111 10861 115019 284129 1811 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 814 88 815 816 4747 817 818 9647 1742 808 2906 2905 2902 8536 22843 1741 1740 2904 57554 1739 2903 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA 18 7915 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling 6352 5724 6348 7133 6774 6347 3976 6349 3569 6364 6363 1437 7297 6367 1230 1440 1435 2919 3557 2920 7850 3554 3588 3383 3576 941 729230 942 3587 5743 3627 7132 2357 3593 2208 3592 7076 3552 3716 3553 3586 3606 7124 1234 6351 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) 6569 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) 338567 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 4851 54492 54567 6907 26508 2033 57534 5664 5663 3280 3714 55851 9759 6868 83464 55869 84441 9794 55534 388585 892 8454 6233 22938 23385 51107 79718 10046 8841 7316 51564 10013 10014 8850 79885 9978 1024 1387 23493 9734 23462 28514 3516 83933 7311 182 102 7314 9148 6500 3066 3065 142678 2648 9612 9611 4609 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism 151531 55270 131870 51733 25939 93034 1807 1806 953 954 9615 84618 955 7378 4907 956 957 30833 7498 56985 1890 64902 10591 4860 11164 377841 22978 56953 57089 9583 3704 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways 147179 3708 3709 718 3710 2771 7474 2770 10006 8324 1535 10458 10451 7525 25 79651 7410 10769 5335 9332 4627 4791 10109 4210 9051 29108 7409 4790 808 10910 23191 10628 5027 834 4651 4644 124056 4620 695 51517 4641 10552 5577 5970 3162 3071 3569 5336 2793 2792 2791 2790 10093 2788 10092 2787 2786 4067 10095 64174 8976 10094 2785 2784 60 10097 2783 51764 10096 10768 7454 7456 94235 998 5594 5595 55970 5566 79792 54331 59345 114548 57105 2268 917 644150 3055 6850 136 2782 2209 346562 1800 2781 10800 26999 2534 2214 6868 2212 3326 2773 10681 10787 5599 5045 1511 10152 3725 2678 1432 71 4650 5025 3552 3553 719 3606 2687 10163 111 112 113 114 115 5747 5613 9844 63916 196883 1398 1793 1855 5573 10811 5575 5576 5879 10810 2778 953 27035 107 108 4690 1857 5567 1856 4907 109 5568 957 7295 55845 3586 8936 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) 3329 22809 1670 23410 3313 847 4899 2099 207 9361 6648 3336 3297 2309 27429 3304 3301 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK 5111 7316 6119 6118 51426 7311 7314 6233 5981 5984 5985 5980 10459 5982 51455 5983 6117 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis 3157 50814 39 9453 91734 4597 64801 3422 6720 7108 2224 1595 6713 2222 4598 10654 4047 3930 6721 403313 10682 6307 6309 51478 1718 1717 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import 5827 5824 10478 215 5825 5195 5193 5194 5828 8799 55670 54332 84896 91452 51024 11264 9409 8504 225 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions 1641 4897 8506 1272 286 6386 23114 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division 8243 9493 5885 23383 5347 9126 23047 23244 25836 23063 10735 10274 10112 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 7296 9061 9060 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) 5295 5296 10818 5290 5291 57498 3667 1108 51231 1849 1848 135 1846 1845 5335 5899 25759 6014 6016 5603 6300 5900 6236 3399 4066 8941 8061 10221 4664 4665 1020 1959 3398 23237 1961 1960 7425 429 6457 4915 8851 2353 5518 2889 673 5906 5594 1386 5595 1399 5604 5605 6654 6774 2033 3726 3397 9261 6197 6196 53358 6195 4205 4208 2002 9252 6456 1175 2152 160 466 161 163 7867 26052 1958 4914 1785 1213 1211 1759 10126 7529 4803 5519 1432 4209 5515 5516 5600 5607 5528 5598 7166 6446 1398 6938 6722 3727 2354 387 6464 116 117 5898 5978 3400 4893 8660 3265 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling 5928 29126 5929 5777 23476 3091 5931 4613 94239 4343 9070 192669 23112 27327 26523 27161 192670 57690 595 7415 4791 8454 91319 54145 25937 6233 4790 58508 1445 8331 8337 920 8334 8335 8405 5970 7316 5133 8341 8342 7532 8347 8348 6934 4780 8345 8340 11160 7004 7003 7005 1387 8338 4751 9861 5682 83439 5683 2353 5684 8945 5685 8463 5686 79139 5717 85236 5718 5719 8349 1499 7311 7314 11047 6500 10213 142678 5713 5714 7979 53632 5690 5691 5692 5693 5694 5695 5706 5707 58505 2932 5708 5709 51176 3659 5687 5688 5689 6774 6932 2033 5700 5701 8370 5702 6048 2146 5704 91445 5705 100128731 917 10956 51422 51009 3013 5562 5564 255626 6400 3021 1460 6185 5571 3018 1459 3017 3725 6184 1457 3014 5563 10413 5565 746 80380 467 1603 5781 474382 2034 27248 1019 8970 128312 9978 10613 55766 8726 8968 3727 2354 10331 84061 6772 3123 3122 3120 7991 3119 3118 3117 3115 3113 915 653604 916 201595 84661 3127 3703 8452 3126 3125 11091 3716 10987 4297 3932 1650 23512 4609 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia 64241 64240 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body 55788 4036 51293 4363 26119 6948 6947 5826 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation 8815 7520 11168 3159 3981 7518 2547 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a 4247 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade 7450 11093 196527 221914 9672 2239 375790 5657 2155 2153 2152 2149 2147 710 2262 5197 7056 3818 351 3053 2161 2160 5270 2159 2158 2157 5104 8858 5624 5627 2817 10544 57126 462 2812 203859 3827 51156 2815 2814 5054 2719 3339 5196 2811 6609 6383 10082 6385 6382 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules 57497 2893 78999 5802 1742 2906 2905 2902 5792 2319 1741 2892 2890 5789 10211 2904 57622 1739 2903 79414 10313 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes 3437 3434 3433 4938 103 3608 4940 9775 5335 8454 6233 4939 8662 7324 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 7316 10480 1964 6230 6232 6231 6234 8575 6895 6235 6227 6229 4869 6228 57506 5608 7334 5518 8678 3661 7311 7314 6500 983 5595 6774 5300 3305 3312 2176 5045 11274 8021 6188 6187 6189 1981 6622 2810 71 3304 6191 6193 6192 6194 2342 2339 1974 1973 1977 317649 3921 6772 5495 2197 3716 140032 3838 6201 2317 6203 6202 1982 378708 23165 9631 6210 7175 4599 51065 6205 6204 6207 6206 6209 6208 6223 6222 6224 9470 6218 6217 834 348995 9883 115361 57122 4600 55746 23279 79023 10762 8672 6396 60 129401 3836 115362 4927 54920 8638 199990 2175 55120 4734 2189 5903 201626 91442 1660 9688 23225 2188 2187 3839 80233 201254 6041 55706 57697 6059 2178 3840 3841 23636 9972 11097 23511 8086 53371 8480 79902 7341 9246 2316 3551 23586 7329 25820 51191 8877 1147 8517 9636 7318 7157 7706 5229 24138 3609 3837 5519 5525 5515 5292 5516 2635 3306 5610 2634 2633 402569 1965 8894 1968 5771 4690 5611 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 5687 5688 5689 8453 5700 3091 5701 5702 5704 5705 64344 54583 7428 6233 7321 7323 84962 2034 7316 6921 6923 9978 112399 112398 7322 126374 9861 5682 5683 8994 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC 25974 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 4331 902 404672 54623 22916 4686 6749 5430 5431 5432 5440 5433 5441 80349 6917 2966 51497 11198 2965 8812 5434 5435 5437 2968 9646 2967 1022 2963 2962 5436 6921 5438 23168 6924 5439 4298 6923 85403 2071 6830 7469 4300 8178 2068 6829 27125 55840 6827 9150 1025 25920 51224 7936 55677 79577 123169 904 905 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN 8658 80351 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation 5567 111 109 112 5568 113 114 115 808 196883 5573 5566 5575 5576 26960 5577 107 108 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events 28964 4900 4747 2891 51422 2906 2905 2902 27330 6197 2890 6196 5562 6195 5564 1739 57554 5571 5923 808 5563 10645 5565 84254 8536 5924 5577 3084 114 814 815 5613 6714 816 817 818 5573 5575 5879 5576 2904 2903 107 5567 5568 88 1742 53632 5594 5595 4893 5566 1741 5170 1740 3838 3265 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint 7156 4683 8370 7533 165918 890 7158 8900 3364 10971 995 51588 641 255626 7157 7534 11200 10111 4361 3018 3017 54145 472 3014 7529 1763 2810 545 144715 80010 5810 672 5932 11073 29086 9025 9156 51720 8924 6117 6119 6118 84142 9577 79184 8341 8342 7532 8970 8347 7531 8348 128312 8345 8340 83695 1111 580 9656 7334 10524 7486 7336 5982 5983 891 83990 84126 7468 85236 8349 983 5984 5985 5883 8290 7465 5884 116028 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 11041 9215 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway 4507 55256 51074 2805 58478 84245 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis 162 164 567 3055 9844 926 2534 8907 5879 8905 51606 55690 130340 1174 940 1175 5062 160 161 163 375 3105 1794 920 3932 10053 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 9682 4683 7341 8370 165918 7158 51588 51035 7329 25 255626 7157 5599 8314 11200 10111 4361 3018 3017 54145 472 6233 3014 672 5536 29086 9025 2070 51720 8924 7316 322 84142 9577 79184 8341 2140 8342 2139 8970 8347 8348 128312 8345 8467 8340 84295 580 9656 7334 10524 7336 9031 7468 85236 8349 7311 7314 23030 2138 8290 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) 5949 5956 6017 611 158835 2652 9249 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm 2247 3975 130497 5076 2296 7849 2303 652 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy 7316 7417 7419 10133 79065 54543 9804 7416 9927 7322 5071 29110 7332 7334 7335 8408 8878 9868 65018 1460 7311 7314 1459 81631 6233 1457 7323 9140 51001 10452 9474 55669 84557 100188893 139341 401505 56993 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling 1816 1815 1814 1812 134 135 140 729230 7222 7225 5581 5140 5726 57113 1235 5660 5588 10235 10125 7074 259289 259287 5594 259286 5595 259285 6654 259293 259292 259290 259296 259295 5153 5136 10846 5138 50940 5580 2652 5578 4852 207 54429 10645 84254 719 80835 80834 111 112 113 114 1392 115 196883 5573 5575 5576 2778 107 108 5567 109 5568 2550 4893 26960 3265 5294 718 5443 1081 9568 7852 2774 3375 6753 1234 2914 23236 23533 6010 2847 10266 6093 57449 5196 83756 8503 10203 50831 50833 50832 50834 5499 50837 50836 50839 50838 50840 1908 1906 4157 9181 1910 4161 4160 2642 4159 2641 3060 347148 3972 84109 8620 64106 10886 3062 3061 133 2149 2147 7252 5519 11343 5515 27198 5516 8843 5528 338442 84904 3827 26084 2779 5613 6714 5321 2245 6387 5020 4295 7200 115557 5021 7201 431704 56413 8527 8525 8526 5031 116 5032 117 6003 1909 6004 94233 2798 2797 2796 1907 5028 151 5029 84432 89846 1902 6375 1241 2693 3688 26090 57406 10874 29933 222545 10887 1128 7984 5724 257313 1133 5731 3708 5737 3709 5295 64407 2911 387129 5296 2358 846 5290 2915 8111 2864 8477 3710 2922 5996 6655 5997 5998 11214 5999 6846 2925 160851 10161 6863 185 623 624 10451 1609 1608 747 1607 10287 5579 1606 56923 6870 8490 2151 23566 2150 7410 3358 3357 3356 1956 6865 2829 9826 2828 6866 6869 221955 9828 353299 7409 885 22899 886 9287 3363 887 3362 5364 2837 3361 5330 6453 9002 3360 5331 8997 57121 338557 5332 8874 59340 153 3814 154 10911 155 2840 3355 695 2846 594857 83551 301 134864 3269 319100 5583 5577 134860 129521 10672 9038 3354 128674 1132 2867 3352 2865 3274 156 2863 3351 5137 2862 60675 1129 4922 4168 2869 4923 680 27334 84634 139189 4935 5367 23620 9162 3640 10316 51083 4828 4829 2692 26575 338398 2520 7204 9170 56670 84539 2691 10636 2695 4985 4987 1131 10888 5729 2696 27199 10768 5741 5739 2587 5732 5518 4886 5733 5734 4887 4889 122042 1394 2359 26086 29 1269 2357 1268 5744 5745 64857 5746 5995 5566 23263 4543 221472 5170 4544 259294 9639 353164 6751 5540 6752 5533 5058 5539 10022 388 79924 389 6755 6754 8811 10268 10267 23365 57105 84152 339403 151306 85397 136 128272 8601 346562 5697 2781 256933 10800 797 2773 611 126006 121512 51289 799 10692 9934 150 8622 152 8862 7433 23370 6344 25791 7432 6288 6343 727 7434 23229 728 5368 5141 796 5143 5144 117579 5139 5151 5030 6001 53829 6002 183 5150 113091 53831 10276 1903 55701 100271715 6915 54848 2768 389337 445328 9459 146 5179 147 148 6019 8698 157 2918 2917 2916 2913 53637 2912 9560 221391 408 11245 55160 8484 11250 11251 1395 23596 57580 186 187 9340 165140 50835 285601 2832 2831 26166 2838 1880 2488 283869 2843 2841 9475 2848 29899 27115 2854 2853 2852 4158 2850 50865 2870 4314 63940 2861 10000 64805 9283 9290 9294 59350 1325 2740 3838 9138 5534 27237 409 2771 2770 1524 208 5582 5530 1894 5532 2780 5956 50649 50650 351 808 1020 5924 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 9630 94235 6000 8787 998 8786 55970 9628 6351 54331 58191 6352 146850 2767 6357 59345 10850 2826 6364 2769 6363 5473 6366 1230 2782 6360 2833 643 2919 10663 2776 6373 6372 6374 10681 6376 6370 2921 6197 6196 57007 2920 6195 1237 3579 1236 3577 3576 1233 56477 1232 4283 6346 10803 10563 3627 7253 122876 26230 170589 3973 2492 5598 814 4986 815 816 4988 817 818 1839 387 5173 3678 6750 551 552 553 554 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis 3906 2683 6513 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway 2525 64377 3972 4122 2517 9486 4124 2530 4247 1081 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation 54490 7358 79799 55347 7363 7365 7364 7367 7366 23169 54659 54658 574537 11046 7360 10720 54578 54577 54576 10941 54575 54657 80146 54579 133688 54600 167127 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 5928 57504 5931 4343 192669 1107 23112 27327 26523 208 27161 192670 57690 1108 54815 6233 53615 8649 8535 7316 10542 51564 7101 10014 6045 23608 389541 28956 648 6015 57521 11060 6009 23466 1912 1911 80012 57332 84733 9861 5682 5683 5684 5685 5686 5717 10273 4734 5718 5719 55004 7311 7314 11047 331 10213 5713 5714 7979 2475 5690 5594 1386 5691 5595 5692 5693 5694 58528 5695 5706 5707 5708 23028 5709 57459 5687 5688 5689 5700 5701 5702 2146 5704 5705 9219 9112 5468 6591 7157 1460 1822 84232 1958 64223 1459 7874 6615 8975 207 3725 81847 1457 23252 5987 8658 80351 57167 2444 23186 8841 64121 5728 10670 5371 153129 8726 10325 80243 2122 3066 3065 10000 5978 23512 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation 1675 1 81 197 7018 7273 7422 7040 5216 5004 5005 1950 1191 351 808 948 3082 6813 5660 5054 5265 213 5196 12 135228 5874 7277 7057 226 7450 7043 27154 7042 5473 2316 10487 5155 2 5267 5478 350 94121 3309 8407 51097 5175 23052 2153 9749 54495 813 7114 3671 710 2266 66005 7414 22915 7123 3690 29106 83706 10184 2243 51571 2162 3699 54863 7044 10490 29789 51368 5552 7076 22927 2157 3920 2277 10916 7078 7873 5627 1521 5099 6414 308 2244 3700 5341 3827 3959 5340 54676 1893 259215 78991 5345 2621 9948 3273 6694 7424 7094 7423 334 2335 5919 55664 374354 10447 10257 87 51706 3479 928 139322 967 3481 6403 5768 3674 88 6647 1072 335 6678 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production 4790 3665 4791 1660 170506 5970 4615 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus 8815 7520 11168 3836 3159 3981 7518 2547 5478 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling 4916 4908 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK 4058 10188 5295 5296 6654 2885 5290 5291 285016 3667 389658 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM 10568 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy 7316 2670 5116 200894 11315 10013 7311 7314 8100 6035 6233 3320 3043 1915 123 3326 3920 10226 1068 1080 3312 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated 5518 1452 1499 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels 3781 27094 3778 3779 3780 3782 3783 27345 10242 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes 8714 1387 10061 2033 4363 9429 4780 7975 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K 5295 6714 4916 5290 4908 3667 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) 6005 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling 3684 3718 51561 149233 5295 3091 5443 9655 3605 595 112744 58480 7422 7040 5008 240 948 3320 4128 301 7124 3082 10538 3162 3569 7431 3566 4692 3565 356 3934 3662 3689 5451 3596 4985 6778 6657 2353 3383 7412 1026 7291 604 6097 596 3929 598 6356 6347 6774 3726 246 6367 6095 3717 3911 79923 3312 7157 7184 3576 6288 207 6935 2162 2309 2308 7076 3552 5292 3553 3606 9021 7133 3976 332 4988 2335 7297 4582 1052 3687 2625 2247 4843 6772 3570 3598 3597 6624 5743 4312 4170 1278 4313 4314 1901 3593 4318 2208 3592 3688 8651 3716 3586 3561 4609 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS 199857 79868 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides 51296 6564 121260 1497 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions 29780 54751 5829 2318 6251 87 2316 55679 3987 7408 3688 10979 7016 3611 9459 55742 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases 27032 51076 23200 476 79895 477 478 479 51761 51248 53822 53826 53828 286410 57198 480 808 481 487 488 57194 489 482 483 486 490 491 492 493 6717 815 816 495 496 817 818 538 9914 10079 57130 540 5205 23400 374868 23120 5350 84239 23250 5348 5349 57205 344905 10396 6588 148229 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation 10628 2309 1387 2308 2033 23411 8850 7295 23410 4303 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors 2810 10000 208 2309 7534 2308 7532 207 10971 4303 7529 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA 7316 22954 23220 81844 7311 3661 51428 340061 7314 147945 11277 6233 29110 6737 81030 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor 2767 59345 9630 94235 2769 2793 2792 2791 14 2790 2782 2788 2787 2786 55970 2776 2785 2784 2783 10681 51764 6915 54331 10672 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 7316 116985 1796 5753 7311 7314 207 6233 867 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR 3791 8828 8829 2321 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 4968 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification 26995 51335 55149 81554 55006 51001 84881 10128 285367 22868 81892 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia 3712 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis 4967 1738 92259 1743 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones 9682 8370 8242 23210 8968 84159 84864 22992 8284 55693 84678 23081 7403 51780 23030 10765 653604 7404 5253 23133 221656 23135 5927 80853 23028 55818 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade 10454 30849 64127 51231 1849 1848 1846 1845 4791 257397 8454 6233 351 4790 5970 7316 7099 929 7186 121260 353376 23643 148022 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 5289 7311 7314 6500 3654 3656 5594 1386 5595 5604 3665 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 5602 4793 5606 28512 57161 3725 57162 177 23118 121457 28511 80216 54106 5519 1432 5515 5516 5600 5528 5598 64145 6885 7189 51295 8411 51284 80231 3663 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors 59345 2793 2792 2791 2790 2782 2788 2787 2642 2786 2692 2641 2785 2784 2691 9340 2783 10681 51764 2695 2778 2696 7433 6344 7432 6343 7434 116 94235 117 55970 2740 54331 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 27338 119504 246184 51434 51433 9184 991 4085 701 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis 5534 7533 55075 4976 208 1687 660 3002 8655 6233 1613 1612 23604 26060 7316 140735 7099 929 8772 7186 6304 1029 8795 7532 7431 8743 7531 8797 353376 23643 148022 355 356 841 5339 8737 8717 3009 3008 3007 3006 5588 54205 3005 1677 1676 3024 3148 3836 6093 1832 9861 5682 5683 5684 5685 23368 115209 5686 5717 10059 51074 5718 5719 1499 7311 9500 839 7314 11047 331 1830 10213 5713 5714 7979 5317 5690 5594 5691 5595 5692 1828 5693 329 5694 5695 5706 5707 5708 22900 5709 57099 572 10018 79792 9414 596 5533 840 4836 27113 5687 842 598 5688 578 5689 56616 5366 6774 637 5700 7159 5701 90427 5702 79658 5704 5705 10971 7161 999 5580 219699 63967 1630 2620 8428 118 7157 90249 51765 28988 5599 3146 4137 7534 2934 1829 100506658 1869 207 7529 7027 2810 3837 708 324 6709 7029 317 836 5747 2339 8626 22985 581 5062 10134 4001 10000 7082 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis 4338 10243 55034 27304 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 84676 10891 23410 25942 5443 4087 91584 4088 4089 2908 6720 3630 23460 2538 2645 181 114907 847 3066 5105 3065 4287 4852 6648 4303 2309 2308 3484 56729 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development 7484 3955 153572 3975 28514 79192 5455 182 6928 54361 7490 3172 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria 7157 7027 27113 23368 7159 7029 8626 1869 7161 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas 2247 3913 10319 3910 1950 3914 3915 2335 3918 3909 2255 7448 2252 284217 3911 3912 2249 3908 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 4851 54492 54567 6907 26508 2033 57534 5664 5663 3280 3714 55851 9759 6868 83464 55869 84441 9794 55534 388585 892 8454 6233 22938 23385 51107 79718 10046 8841 7316 51564 10013 10014 8850 79885 9978 1024 1387 23493 9734 23462 28514 3516 83933 7311 182 102 7314 9148 6500 3066 3065 142678 2648 9612 9611 4609 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle 8500 10815 1103 6844 6616 5864 10497 9256 6857 6572 60482 6804 8541 8497 22999 8499 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid 126 127 8644 1592 6257 51109 6256 6258 5915 1738 5916 1737 5467 5914 56603 5166 5959 216 5162 1382 5163 5164 2171 112724 5165 10170 9249 8854 64577 157506 1381 5160 5161 220 8050 10901 195814 57665 8608 340665 124 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 84188 25979 8540 55711 158835 158833 8443 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair 6119 7516 7156 6118 5892 5889 4683 79728 3364 83695 580 641 10524 7486 5982 5983 83990 84126 10111 4361 472 7979 1763 545 144715 80010 5984 5810 5985 5888 672 5932 5883 5884 116028 11073 10635 5890 9156 675 6117 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling 2247 2248 2255 27006 8074 2249 161742 53834 8817 200734 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 7082 92359 10207 2697 64398 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling 145957 3084 5295 1950 2549 2064 2069 1956 5290 685 10718 1839 9542 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling 145957 5578 3084 1950 2064 6464 2069 1956 5782 685 10718 5581 4893 5580 6654 1839 3265 9542 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones 26610 55683 317772 23587 55140 55689 8648 85235 54859 5931 10445 23326 55167 10933 23338 10943 56943 9913 51147 6881 6880 6883 221613 23522 8295 54556 54934 56970 92815 8969 8607 440689 79960 10902 6314 339287 8520 8331 8089 8337 8334 8335 1810 51562 8518 8341 8342 8347 8348 8345 8340 1387 60 8338 10524 5077 8473 79595 57325 84148 85236 8349 64769 9575 1386 51230 86 6871 2033 27154 8370 284058 10499 84289 3013 7862 255626 7994 3018 3017 10474 23774 8970 8850 128312 8968 3054 26009 57634 27097 55578 9767 9643 112869 653604 117143 10856 11143 6944 8464 2648 55929 11091 93624 55250 80314 55257 10629 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion 27248 7316 5687 5688 50846 5689 5700 5701 6469 5702 5704 5705 10956 84447 55733 51009 9861 7415 5682 5683 5684 5685 5686 6400 5717 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 3549 5693 5694 5695 5706 5707 5708 5709 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands 7157 23368 8794 8795 7159 8793 8797 8626 355 124446 3486 7161 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis 596 5533 840 4836 842 27113 598 578 56616 5366 6774 637 7159 5534 90427 7533 55075 10971 7161 208 1687 3002 7157 5599 7534 8655 1869 207 7529 7027 2810 708 7029 317 140735 1029 7532 836 7531 8626 841 581 54205 23368 51074 331 5594 5595 10000 22900 572 57099 10018 79792 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 10454 5599 5609 6416 5601 64127 257397 5602 23118 3654 6885 3656 8767 7334 7335 7189 8517 10392 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells 81539 2752 6506 6507 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration 9358 10000 208 4322 3678 865 207 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 79611 38 622 65985 3158 56898 3155 54511 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR 7039 1950 374 2069 1839 1956 685 255324 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape 5436 6908 4331 5438 5439 902 129685 6872 404672 6874 2071 6873 138474 2068 6881 6880 5430 6883 5431 6882 5432 5440 8148 5433 5441 6884 2966 2965 51616 6875 6878 83860 5434 6877 54457 5435 5437 2959 2958 6879 2968 2957 2967 1022 2963 2962 2961 2960 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 6907 5469 2033 85441 8648 1374 10891 6256 80205 96764 5465 6095 10499 6604 10498 9572 23054 79718 1387 8204 6720 6097 9611 8841 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants 7450 5908 5245 22866 815 816 6714 817 7094 409 818 2335 369 4296 408 3717 10256 3845 3674 283455 4140 2266 7414 3690 5037 2243 54518 7529 673 8826 808 5906 5594 5595 1445 4893 5604 5605 8315 3265 5894 2244 8844 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain 2157 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism 55788 4552 51293 4594 27249 6948 81693 5826 8029 25974 4548 326625 166785 2694 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal 4255 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) 4067 3717 2057 5335 5336 2056 8660 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP 650 6497 57154 92 93 94 4086 9350 4089 9765 9241 64750 657 4091 658 4092 659 11167 268 269 91851 4090 4093 27302 7321 7049 64388 2658 7323 3624 3623 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 9212 23421 51143 25909 9183 401541 54821 9184 64105 23122 991 4085 701 378708 1780 79172 81930 84643 55920 3796 57405 7514 1783 83540 80152 10403 8655 3619 80776 64946 1781 11243 5519 1778 348995 5525 5515 5526 57122 5516 5527 699 11004 5528 5529 91687 57551 140735 55746 79682 11130 25936 9793 332 23332 6232 23279 79980 2491 79023 55839 54908 8379 5347 55143 22919 6396 55166 5048 10726 79019 151246 1063 9735 1060 151648 5905 5518 1062 1058 5903 79003 55055 220134 81565 57082 54820 5501 6249 147841 79902 348235 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism 38 26275 64087 152926 3712 56922 10295 593 1738 594 1629 549 1892 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy 8408 9140 1460 9474 84557 1459 81631 139341 1457 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants 7450 5908 5245 22866 815 816 6714 817 7094 409 818 2335 369 4296 408 3717 10256 3845 3674 283455 4140 2266 7414 3690 5037 2243 54518 7529 673 8826 808 5906 5594 5595 1445 4893 5604 5605 8315 3265 5894 2244 8844 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair 10714 5424 8370 57804 10038 94239 54107 26277 25913 65057 7013 3013 7014 54386 6996 255626 79661 55247 3018 3017 54145 3014 8331 8337 8334 8335 474382 6117 5111 6119 6118 4913 4968 8341 8342 8970 8347 8348 128312 8345 8930 11284 23583 8340 8505 252969 55766 54936 5423 328 142 8338 5982 5983 2237 85236 8349 4350 5981 56655 5984 3978 5985 7515 8290 5425 5426 5427 3980 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction 2534 1794 5062 5879 3055 3932 9844 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones 10954 55033 10130 9695 10113 84447 2081 10106 118 3309 9797 116138 9114 9570 58477 2931 1663 1200 10897 5526 64061 37 2137 2135 51726 7094 56005 2134 6734 6745 7709 55738 10525 6818 3068 2673 100137049 4189 7466 6464 9820 1639 11015 55062 27230 4000 5611 22872 30827 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 11194 23456 22 10058 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules 23428 92745 6511 6533 6510 206358 84889 6509 55089 117247 340024 10991 6506 7781 6505 6532 23516 7780 54716 6507 64116 29986 9056 25800 9057 8501 57181 27173 153201 1244 6541 29985 81539 283375 7922 123096 23657 7779 55117 115584 56301 114134 6526 1811 11254 6512 6540 10058 11136 6519 10060 140679 124935 54407 6529 4151 58157 51248 215 7220 7222 7442 7224 7223 7226 7225 59341 79054 55283 26133 54795 8989 10861 55503 4308 162514 255231 6556 57192 80036 56302 4645 51393 22841 57113 57468 29850 6560 54822 140803 114757 10723 6558 51296 6564 121260 53919 6576 6248 28231 11309 6567 284111 9058 51360 11059 9356 159963 338328 538 64849 3934 65010 6520 115111 115019 116519 6513 6515 9861 23460 5682 6514 5683 5684 5685 55240 5686 5046 5717 154091 5718 155184 5719 144195 80772 66035 11047 83850 10213 5713 55974 5714 6527 7979 125206 6561 55532 5690 6574 5691 6568 5692 254428 91749 5693 11182 5694 85414 5695 84102 51228 5706 200010 5707 57488 26266 5708 1317 5709 1201 6528 7417 10568 5687 6569 7419 5688 142680 5689 341 5034 5700 346 5701 4363 338 4547 5702 5704 8720 5705 8884 6582 6580 57084 57030 8714 6536 345274 6534 60482 6539 6538 1468 5825 6548 5244 79751 111 112 113 114 115 7416 6584 6583 6446 196883 6579 5573 5575 5576 2778 107 108 5567 109 5568 84699 10559 376497 113235 23327 64078 347734 23443 292 2030 293 23568 55343 389812 10999 3933 286256 7355 28965 222962 3177 9197 120103 9153 9154 84912 55315 347 213 3949 8766 84679 6550 57127 6553 51458 389015 6549 23315 3954 10479 285195 7376 29988 4738 11046 118 1175 160 161 163 23446 126969 1213 1211 23491 9429 291 9376 6581 90550 204962 91689 6687 5245 9512 10939 23203 55486 55013 79568 221154 11331 30968 10367 10730 10257 286097 11194 51706 23456 56606 606495 23457 51167 10349 26503 51700 89845 85320 10347 20 23 340273 10350 64137 23461 10351 5243 8504 225 9123 284129 23539 8140 2040 6563 8170 55244 28234 115286 146802 85413 55356 1080 57153 537 26119 246213 51000 80736 65125 1187 23200 1186 8435 57552 1185 1184 51599 4864 1183 1182 6646 861 1181 255738 133308 3988 1180 10577 476 55832 79895 477 478 1179 479 51761 150159 53822 7439 53826 155066 51802 9114 53828 8454 22802 219931 286410 6233 9635 57198 480 1193 10599 481 2281 57194 482 483 91289 486 55908 523 3990 1188 5125 525 64788 526 27329 26291 527 528 529 5577 10786 285175 3163 7316 65266 3162 65268 65267 285335 127124 23545 51382 495 496 144453 533 534 535 10110 9388 9914 63982 3931 10079 55911 3767 50617 6263 6262 94015 57130 6261 23678 540 28962 5205 55515 40 41 266675 245972 245973 23400 8402 374868 54831 23120 9311 5350 161003 259232 7311 120 9550 7314 29801 84239 7809 6500 444 23250 284525 55107 5348 160728 5349 10345 8992 90423 57205 1831 344905 5566 10396 10312 6340 6588 5894 9296 80727 83733 57578 148229 27032 51076 53373 6337 6339 6338 6048 91445 55129 10956 51009 2 759 10057 10062 5045 760 762 23344 121601 1836 319 4018 7037 203859 5824 84725 57101 51128 81693 682 8029 10613 2512 338440 9194 2495 64924 133418 123041 84061 169026 7991 9843 5002 335 336 337 9497 50636 6517 10539 344 345 94033 79689 348 7018 3658 7036 26154 196527 3077 51310 79901 57719 23169 80024 57419 25769 7415 9498 19 23382 83697 6522 57835 6508 22 57282 91319 808 487 488 489 375 6543 6546 55630 6547 490 491 492 493 6717 23507 57185 57380 56172 152519 55144 54896 1497 6005 2793 119 9990 2792 79815 368 56262 2791 93380 21 2790 81614 11160 563 24 48 2039 8671 2788 348938 2787 5304 2786 80131 5172 123606 2785 84230 2784 26234 2783 51764 79139 94235 9152 55970 402 81031 9187 54331 8165 59345 4284 360 375318 361 362 363 364 282679 343 366 6521 358 2782 51129 359 89872 3043 6531 29116 6530 6524 6523 10681 30061 3040 353189 64241 64240 6566 6400 6557 6559 6575 7436 3069 6578 9619 1071 283652 27248 116085 815 816 817 818 4023 1356 1965 8894 1968 4891 51606 551 554 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing 6431 22916 6427 6426 79622 4686 11325 23451 5430 5431 9343 5432 5440 5433 5441 10907 5434 5435 5437 24148 83443 2963 2962 6632 5436 11066 51639 5438 5439 10081 6628 55599 6634 6633 10992 6636 10262 6635 8233 6637 55954 154007 85437 23450 23020 10594 9410 9416 4904 6432 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation 4851 2033 8370 94239 4343 192669 23112 27327 26523 27161 192670 57690 3013 595 861 5584 255626 100996717 7157 84441 9794 3021 55534 4853 4854 4855 3018 1869 3017 54145 3725 3014 22938 1991 7027 1871 51548 1999 8331 8337 100996763 8334 388677 8335 7029 10046 474382 8341 8342 8970 8347 8850 8348 128312 8345 8340 55766 8968 1387 8338 3516 85236 8349 653604 2648 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription 5928 60436 8370 5931 2146 94239 3013 6591 255626 3021 116092 3018 94234 3017 54145 6615 5315 3014 10009 6935 9839 348262 8331 8337 117581 7750 8334 8335 387893 474382 6929 8341 8342 8970 8347 8348 128312 8345 1488 8340 1487 55766 8726 8968 6938 23411 7764 8338 85236 8349 7490 3066 3065 653604 7291 54737 5594 5595 7088 6597 23028 23512 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication 3320 3326 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 708 1029 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids 4056 5446 2877 240 2876 241 5444 5445 2879 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase 7316 5520 4331 1019 1032 1031 1029 894 898 896 1017 902 5925 9134 1027 1028 4067 3717 5753 595 1021 25 1874 28227 1163 5518 1030 7311 8454 7314 6500 1869 6233 1870 1026 7027 1871 5519 6502 5515 5933 7029 1022 5934 5516 1875 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 8708 2525 8705 2524 2523 10690 30815 2529 124872 2528 2527 28 6007 10317 6484 6006 10402 6487 8707 2526 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) 59345 79924 10268 10267 7855 7976 51384 8321 8322 7474 2782 8325 8323 2642 8324 7471 2641 11211 797 10681 799 2535 114131 133 7433 6344 7432 6343 7434 8643 1604 796 30817 3375 3549 113091 7473 7472 7475 7483 7477 8326 7476 7479 7478 50846 1392 7480 7482 6469 2793 2792 2791 2790 7484 2788 2787 2786 90226 2692 6608 2785 2784 10266 9340 7481 2783 2691 51764 89780 2695 2778 2696 5741 80326 10203 5727 116 94235 7349 117 54361 1394 1393 5744 55970 5745 5746 976 84658 2740 2015 54331 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation 9554 51143 5373 79868 5887 29929 2801 4758 4759 2890 4905 26958 51014 10945 23423 372 381 8655 6233 1781 9382 9276 11316 1778 22818 1314 54732 1453 51226 22820 7316 140735 11014 79644 6712 6483 10540 6482 9871 6484 6487 9632 1075 93661 8869 6480 10427 7039 256435 27090 55860 288 11282 7311 7314 51164 84516 1294 10671 10121 8703 58505 11258 8704 8702 821 7369 79694 432 433 5700 9695 6048 91445 80267 100128731 10206 56886 10956 267 10610 81849 84447 7844 10299 55757 11236 51009 3630 29906 84364 23256 966 6185 1604 6184 9334 9331 11253 746 140838 1603 84620 55907 55808 8775 6489 7841 10020 54187 80896 7903 129807 51128 286 85365 2804 84061 79947 55741 11320 7991 1522 3098 57134 4121 10559 30815 9486 4245 10905 4124 10802 79087 26286 201595 10484 10195 3703 1650 4247 4249 199857 375056 25834 4597 4253 1081 11070 9761 1780 5589 64772 55768 51035 79053 79090 29880 256281 7415 1783 23193 2530 27095 207063 84920 144245 197258 81876 7264 8790 29926 29925 375 377 2762 5372 57171 282969 10342 51399 5476 54344 7109 22796 6399 55343 5861 374 84342 91949 25839 378 51272 126003 83548 58485 57511 9527 51693 6396 10466 9526 122553 55738 10825 5265 2923 8774 116150 23243 22870 2348 64841 10175 55577 10972 2673 5537 9117 6675 11196 5973 79139 51005 64689 8729 83696 55291 5238 254263 9945 25956 55014 81562 1639 63908 8615 149111 56052 9919 11015 90411 10282 26984 79748 128637 89866 10960 22872 6708 79796 811 6710 22845 829 10113 2720 10652 3998 4351 64377 338596 51046 3972 4248 830 4122 832 8128 2517 6400 2683 2153 9570 57731 91869 6811 287 10959 51332 2157 6709 10402 2525 1315 6711 124872 1798 26503 440138 8813 8818 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex 90780 7316 5929 283149 26108 6932 6934 1487 9070 208 4221 57680 83439 83595 7514 6657 8945 7534 25776 9757 64321 9580 1499 7311 7314 331 6658 6659 3065 207 6233 56998 84661 6662 55553 324 11091 7088 7089 7091 6736 7090 51176 607 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 3589 5008 3976 133396 9180 1489 9244 7297 3572 386653 1271 1270 3717 3977 3716 23529 3590 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 5928 5929 10319 650 896 5802 3280 6279 7422 200845 729230 6280 5494 25937 5726 1235 5054 11059 23493 9861 23462 5682 5683 5684 7039 5685 5686 28514 5717 51592 3516 5718 5719 1499 11047 10213 5713 5714 7057 7979 259289 3955 259287 5690 259286 5691 7050 259285 5692 5693 5694 5695 5706 259293 5707 259292 5708 259290 5709 51176 4851 5687 259296 5688 259295 5689 5700 60436 5701 3726 5702 84870 5704 5705 5915 5916 5580 9261 3315 7514 5578 7534 1981 207 4852 54429 7529 1432 3549 5600 8650 3562 80835 7289 3559 3558 9742 23322 80834 55081 111 112 113 114 1392 115 55764 51684 1452 79659 9978 374654 8100 83737 80199 51098 55811 79809 26160 196883 6608 11127 4435 57728 5573 5575 5576 23432 2735 2778 27152 107 108 5567 109 5568 57539 54903 2737 5727 2736 54778 23439 6662 8452 4893 9462 4763 64926 84078 8831 3265 399473 10156 161742 200734 22821 153090 8437 5921 5922 3164 718 22916 23327 4686 7525 5430 5431 5432 5433 7852 8812 2958 2957 7323 348995 57122 2963 2962 1234 5436 2914 55746 5438 7101 5439 6498 6497 6258 23279 79023 4086 4087 4088 4089 6396 142 64750 4091 4092 2904 5196 83756 5905 10273 1025 50831 50833 50832 50834 5903 50837 50836 25920 50839 50838 50840 8086 79902 904 4904 905 1875 57154 1437 3551 1147 2289 8517 6456 1175 2152 160 2149 161 2147 163 26052 2266 4914 3690 1785 1213 1211 1759 2243 10126 4803 8312 23401 5519 324 10023 5525 5515 5526 5516 5527 5528 139285 5529 11140 2244 55914 3827 5245 2779 5613 2591 5327 7484 152559 5778 1844 7058 1843 7481 1847 2625 200958 2668 2247 5795 5979 2122 182 54361 54764 2674 3400 8516 3688 285016 3561 4192 389658 4609 3718 29126 238 5777 639 5295 3091 5296 10818 5290 5291 5764 4613 3667 5803 4343 192669 23112 27327 26523 27161 192670 57690 595 861 864 865 7040 3845 155066 9114 5899 25759 51741 6014 6016 5603 5900 7321 4790 5800 9287 3363 3362 3361 3360 59340 153 523 154 155 3355 525 83551 526 134864 527 319100 528 134860 529 9038 5970 3354 1132 3352 3274 3351 3350 127124 3569 23545 1129 51382 11255 6934 6232 533 534 535 3640 50617 51083 8767 90226 2692 338398 1240 56670 2691 10636 6484 4985 4987 6487 3792 10888 5729 245972 2696 245973 27199 5741 5739 80326 2587 9641 5732 4886 5733 5289 5734 9550 4887 4889 122042 1394 1393 3654 2359 26086 1269 2357 8992 1268 90423 5744 5745 5746 976 5995 4543 10312 5170 4544 259294 5894 2015 353164 9296 2697 6751 5540 6752 5533 5539 116512 54886 10022 79924 6755 50848 6754 2280 57530 8811 10268 56288 10267 57105 84152 339403 51384 10971 6850 151306 85397 136 163404 8601 346562 5697 2781 10800 256933 79948 2534 11211 29110 7504 3326 797 2773 611 126006 10253 51289 8569 799 10692 9934 51135 4142 8622 4615 8862 51052 114131 9718 7433 6344 857 6285 7432 6288 6343 7434 8643 5368 5141 5143 2262 30817 5144 117579 23118 5139 5151 2931 5030 2810 6001 54106 10755 53829 6002 7049 5150 113091 53831 1903 51114 7473 7472 7475 127933 255324 7477 8326 7476 5781 7479 5179 7478 9890 64748 6019 8698 7480 6194 7482 157 51125 2918 2917 2916 2913 53637 7297 2912 9560 6885 221391 408 11245 8484 11250 11251 23596 186 187 9340 165140 50835 285601 2834 2832 2831 7189 26166 2838 6772 1880 283869 2843 2841 57486 2848 29899 8829 27115 2854 2853 2852 2850 1439 3276 2859 1438 50865 1889 2870 63940 2861 64805 10000 9283 9290 9294 7082 59350 84658 3716 8651 1325 8660 2532 3838 6736 1655 85455 57758 147111 10454 5145 144165 1212 30849 5534 5158 5148 7533 409 7855 7976 51701 8321 8322 7474 8325 8323 8324 208 7471 5896 4919 5897 6259 5582 4920 5592 5530 5532 2780 2535 81029 7415 2775 257397 7428 808 487 488 489 908 23608 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 7332 51764 10376 10574 10576 4734 9630 94235 6000 10193 8787 8786 55970 402 9628 54331 2767 59345 898 2769 2782 29116 2776 10681 8877 5584 100996717 84441 9794 5870 6400 2683 55534 56983 4853 5986 4854 4855 1869 3725 23509 22938 7027 1871 7006 10959 51548 1999 4242 100996763 388677 7029 10046 10402 51719 5607 5598 9542 2909 2034 53916 9021 3084 1019 10657 27043 10656 1017 2069 10457 5829 1027 685 120892 9564 9844 116985 63916 1796 3563 1398 10718 1793 3560 55620 5753 3568 1839 5879 6725 5770 6421 202559 387 5771 867 145957 2194 8887 8065 9040 10250 7919 1816 1815 1814 1813 1812 7185 1739 134 9986 135 81926 140 5156 377630 80004 58489 51104 3178 54845 7222 4670 3187 2251 23543 7073 7225 7072 5725 1500 10399 2060 5581 57113 8772 7186 8795 8743 8797 355 356 841 8737 8717 7322 4067 5588 4792 10235 115727 10125 4915 8851 627 7074 5046 7046 7048 2889 673 5906 5594 5595 1399 5604 5605 6654 2254 8074 2249 2246 10817 8823 8817 26281 842 341 5034 346 5153 5136 9184 10846 991 5138 4085 701 50940 1455 3630 2652 8556 8555 8682 10642 221002 340481 2118 5863 9693 8878 989 2322 54756 84292 57139 5596 5825 5597 8975 81847 23252 5987 8658 80351 2444 10645 84254 57761 719 1975 1977 5867 53834 88 2550 4548 2562 2561 2560 1741 2554 1740 26960 2567 2566 4747 55879 5443 1081 2906 54659 2902 55512 57554 9568 6794 2774 5923 3375 6753 5147 261734 23533 6010 2847 5467 8976 10226 216 8503 5499 4908 11069 4052 7043 4053 4054 5664 130399 7042 56937 91 92 93 94 8928 8425 9350 4617 4738 4618 51377 55851 83464 9765 9241 657 658 659 11167 6925 11171 268 269 91851 4090 23645 4093 3693 8837 3694 3685 4654 4656 10468 10589 117145 25805 10272 27302 7252 83855 3696 9958 51107 3070 64388 2658 3625 3624 3623 27198 8843 338442 132884 2121 23288 51109 2622 84455 84888 25999 90268 8439 56928 64759 84951 51523 9126 2288 8204 6387 7764 10735 3727 3169 2354 9166 9687 23189 10274 7033 8243 7392 7391 7031 5885 7010 6464 284 3708 3709 2864 3710 29904 92335 2887 81617 3643 55437 3002 1287 1978 1592 7059 156 5137 80310 7060 256076 1131 1286 1285 1284 10768 1282 22873 25989 339745 131873 1152 1293 1292 1291 5501 9736 8724 10956 84447 51009 10728 6591 5155 118788 2323 930 5159 6801 23035 84335 940 941 942 1822 84232 1958 2264 23239 6615 6199 50852 90865 8870 9965 57167 152831 5563 9173 9846 5565 2277 100271715 6915 54848 2768 389337 445328 146 147 148 7424 2342 7423 2339 2335 1488 1487 55625 858 10256 5593 2670 4140 4158 5105 5037 64840 1901 26508 8644 344 348 83999 6472 1524 3714 2885 2321 5228 9047 6461 5959 5956 19 3791 23179 283455 5162 5163 388585 5164 5165 11221 5160 5161 6455 6457 6469 369 9530 27121 27123 9500 26574 9148 30011 146850 54492 22866 57534 22808 3480 9110 55733 54894 1629 64241 64240 7414 26230 8315 27248 50846 7094 79412 3570 22943 5782 4722 54518 10411 551 552 553 554 558 8844 80824 54567 11108 4040 4041 8471 91452 343637 83595 8549 55366 51699 1852 51339 1850 9559 25776 440193 340419 84133 9580 55737 8036 6658 6659 79971 284654 50999 59349 56998 59352 55553 23072 5140 5792 3416 8405 340665 113878 23220 92737 8788 1272 5660 1840 10498 4058 10188 1382 2173 2172 2171 10608 6788 6789 5481 60485 26524 11033 27018 10750 55233 9113 92597 154810 3925 2241 51421 10076 8483 1447 56603 6692 3249 4485 4486 10653 5230 51072 10434 8776 5294 5293 23163 8408 382 9217 23236 1738 1737 8396 8394 8395 3930 3954 1908 1906 4157 1910 4161 3397 4160 2642 4159 2641 3060 347148 3972 84109 8620 64106 10886 3062 3061 4846 5728 5020 4295 7200 5021 7201 431704 56413 8527 8525 8526 5031 5032 6003 1909 6004 94233 2798 2797 2796 6610 1907 5028 5029 84432 1902 6375 1241 2693 26090 57406 10874 29933 222545 10887 1128 5724 257313 1133 5731 5737 64407 2911 387129 2358 5783 846 2915 8111 8477 2922 5996 5997 5998 5999 6846 2925 160851 10161 6863 185 623 624 1609 1608 747 1607 10287 1606 56923 6870 8490 2151 23566 2150 5305 3358 3357 3356 6865 2829 2828 6866 6869 221955 79837 353299 885 8826 886 887 2837 9002 5330 5331 57121 338557 5332 3814 10911 2840 2846 594857 301 3269 5583 129521 128674 3163 2867 2865 2863 2862 60675 6667 4922 2869 5336 4923 680 27334 84634 139189 4935 5367 23620 9162 10316 4828 4829 26575 2520 9170 84539 2695 3952 50937 64399 91653 2619 4804 81610 58513 10252 14 5796 8038 26018 29924 84985 55824 5774 124 126 23463 127 6257 166 51422 23396 27202 150 152 10062 727 728 1604 183 4209 10048 7166 3730 9402 3479 1395 2488 7349 8050 2740 2771 2770 2242 4952 6300 351 9101 4145 26469 7483 6423 11197 6422 50964 3082 5908 4233 85440 2549 374 9982 83888 2248 2255 2252 27006 143282 89780 83439 6657 4602 7248 7249 1062 64837 10019 80005 147700 998 139818 55619 23028 6351 29127 58191 6352 6354 6357 6356 6347 6349 10850 2826 6361 6364 9034 6363 9927 5473 6366 6367 1230 6360 2833 643 81930 2919 10663 6373 3717 6372 6374 84643 6376 6370 832 3796 1238 2921 57007 2920 3831 3798 1237 3579 3799 1236 3577 3576 1233 56477 1232 4283 6346 10803 51554 10563 3627 81704 23348 7253 122876 170589 1795 23186 3973 2492 1794 80820 9619 1071 89953 55669 10123 11004 9732 57572 10603 9146 51606 57680 3481 7879 5173 3185 5062 5898 4001 1072 6510 51231 1849 1848 1846 1845 4627 6236 3399 8649 4066 8941 8061 10221 5933 4664 4665 1959 3398 23237 1961 1960 7425 429 10542 8550 8793 253260 389541 28956 4193 57521 1111 6712 6009 9099 10524 2353 55240 55004 835 1026 53632 2475 1386 843 58528 9212 79109 5300 3337 995 55615 5562 5564 1874 5571 64223 7874 64121 332 6446 10670 5371 153129 581 10325 3673 83933 112724 23030 10170 9249 8854 64577 157506 1381 220 5978 10901 195814 57665 8608 55818 9682 55869 8295 23081 8607 221656 2324 1003 347 11180 7126 1362 10266 390 57584 29766 22852 6093 394 1832 57449 222584 55704 11188 3895 54514 10203 10970 55789 8502 8301 91544 81839 27316 9231 9352 23513 57216 56667 10505 253980 23592 667 1828 1969 2319 3815 4916 7450 65124 25909 7376 9183 9181 55200 2056 5241 79658 6256 399693 253959 5930 10652 2099 3998 23616 367 124540 115703 201176 2316 2908 10788 57514 9759 5468 57636 57630 55219 64283 5914 10424 10787 143098 4628 4629 57405 55227 7157 57522 4983 133 26092 1495 66008 22865 1460 79784 10403 124997 58504 81624 1459 1124 80776 1457 1123 10409 55114 6811 4637 708 4638 22836 4650 11343 4771 6709 25780 27289 5536 10979 114793 4646 4649 4660 91687 57551 84904 79682 26084 57679 6711 5747 6714 5880 5881 114885 2010 2491 55023 57569 79598 55143 3336 5321 284119 2245 27145 613 6722 5756 26050 92799 10602 57579 2017 10726 27035 10963 4690 115557 1063 1060 151648 55843 752 54874 1058 64321 55968 116 10134 117 4688 55845 10254 23768 4689 23769 4580 23767 2040 55971 51133 151 54763 23286 171558 55852 89846 2208 11113 9787 59 10144 5087 9901 51138 10460 85360 8936 5337 1080 4099 348235 5338 57142 4974 64333 84894 7984 25963 23421 147179 11329 51143 57678 79834 537 9912 64105 2185 23433 101059918 116984 79822 6655 9928 11214 10006 10489 23526 6793 5585 6434 9306 5586 286205 10458 10451 54438 9815 10211 5216 5579 5217 157285 29062 9938 23779 1950 7410 5335 9710 2064 51291 1956 5590 10109 54443 8454 9826 9824 8655 90627 9828 6233 7409 22899 1781 3320 5361 64130 5364 6453 8997 1778 8874 124056 56990 5125 3183 695 1454 699 27329 7535 10552 8987 5577 10672 140735 7316 10435 9738 3071 10133 25936 4162 9793 7431 7532 9855 3083 7531 4168 80728 25813 23332 79980 224 79869 8773 54908 5500 10093 4296 5347 11060 22919 10092 7444 10095 10094 7204 10097 9743 4659 8654 10096 94240 23048 5048 354 29941 85415 83478 8945 151246 9735 84681 6242 5518 7454 11075 7456 9754 7311 120 7314 84317 143872 6500 9748 27 9886 8481 29 9644 983 23268 220134 57082 54820 64857 23380 23141 5566 23263 221472 6249 9639 51306 9411 7112 572 8440 9414 10018 5058 596 28964 598 94134 200894 6774 388 389 9528 5663 54821 5063 3914 23122 1215 3915 23365 23002 3918 391 1299 644150 1298 392 4323 393 128272 999 23129 395 4325 26999 396 397 6868 398 399 3911 121512 3912 55920 51566 84364 10298 171177 51209 148170 23013 1509 23256 94274 23370 25791 5045 1829 9322 23229 8476 10152 64411 796 23221 3817 23344 89839 23580 1991 84144 11243 23385 70 10395 51466 71 7077 10398 51347 7076 10276 55701 9318 2802 65992 5099 57610 7037 9459 10160 10163 9578 11130 5340 25894 55831 128239 836 1729 11135 89941 8239 51479 54509 55839 55717 56924 87 8379 55160 10928 91010 9341 57580 1855 26030 10811 6696 55288 10810 80243 55166 1730 56254 79019 1857 1856 22800 9235 93663 9475 8027 1297 26049 9590 57473 102 7170 3909 7171 57591 79003 4313 1742 55055 123720 26286 4314 80115 4316 81565 1627 4318 9367 158747 57120 8153 57480 117289 147841 6597 84986 50855 3932 343578 50619 50618 9497 6908 6907 157769 9138 57504 22906 221178 2057 8648 401541 5931 27237 55075 653361 57498 257106 94239 84612 50508 9070 378708 153478 1107 1780 79172 57144 114822 57381 1536 1535 29984 1108 1894 445582 58480 23092 3728 25 5166 30851 2631 2873 1783 144402 347902 4810 83540 80152 9757 50649 54815 29843 2886 50650 5910 8202 54145 3619 152273 79180 64946 9055 23191 80179 53615 1445 23074 23075 8331 23197 8337 8334 3984 8335 3985 103910 51517 1020 5924 7124 8535 4772 51564 6348 8341 10013 8342 10014 8347 6045 8348 8345 79885 3567 9048 64096 648 8340 7528 4902 4684 6015 2675 23466 1024 5623 1912 1387 1911 5451 60 8338 9734 80012 57332 84733 6777 6776 2494 6778 85236 27005 8349 220213 330 331 10616 142678 56957 7132 7375 55072 81858 1540 9825 7128 329 284217 7088 7089 8290 2676 79577 2932 7015 7091 7090 57459 123169 6708 607 90780 8313 283149 6710 26108 6932 2033 8370 2146 5786 9219 10499 9112 8828 4221 3013 6197 53358 6196 6195 4205 4208 255626 5440 2002 5599 5441 9252 3021 466 57731 892 7867 3018 3017 3014 5434 5435 5437 2309 79718 2308 51332 10413 8841 474382 6929 814 4986 8970 815 816 8850 4988 128312 817 818 25942 2100 55766 8726 3675 8968 6938 3908 1786 2874 3913 5346 3910 3674 5469 3678 6319 1030 3066 1278 3065 653604 4303 84661 2648 11091 6750 9612 9611 23512 6678 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma 7039 1950 374 5335 2069 1839 1956 685 255324 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense 5045 2342 5229 2339 2634 2633 2810 834 71 60 115361 5292 115362 2635 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency 5009 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination 5453 3915 6663 5454 57211 7003 79966 3156 1821 1595 3912 84059 4359 57716 4155 5376 3908 6721 3066 25937 1605 7402 10413 4664 4665 6597 1959 4099 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair 9146 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins 55746 23279 79023 10762 23165 4869 6396 129401 9631 7175 4927 7514 5905 8021 1104 5901 5902 5903 9688 23225 3837 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 3773 3766 3758 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance 1616 546 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 2767 5520 5747 2776 3551 4792 5770 1147 25 8517 6772 9780 9641 5518 3678 3685 7414 3690 4790 5519 84290 10413 5515 302 3688 824 826 5970 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway 56656 120065 121275 120066 283365 390883 390882 390649 390648 124538 283111 4991 4992 4993 442184 442185 442186 79310 79317 284433 341799 219954 219952 121130 79541 79544 121364 125963 125962 4994 79549 4995 283694 121129 219965 130075 219960 390431 390433 442361 390436 390437 390439 341418 79334 341416 79339 219959 219958 219957 219956 283162 138804 65055 138805 283160 138802 138803 390441 390442 390321 390201 390323 390445 390326 390327 144124 254973 144125 79324 283159 219968 127608 219865 219986 219983 219982 390892 219981 401994 401993 401992 285659 81309 79473 81797 390538 7932 219858 219875 219874 219873 219870 390429 79346 79345 26188 81300 26189 219869 347168 26716 286365 283093 283092 347169 138799 390113 134083 391211 392309 150681 338674 338675 340980 283189 219417 219438 219437 219436 26707 219432 219431 126541 338662 403282 403284 127623 254879 283297 219429 255725 284383 219428 126370 219447 390271 390151 390152 391121 441308 390154 390275 390155 441669 390157 390036 390037 390038 441670 158131 138882 138883 138881 23538 390162 219453 390167 390168 347468 219469 219464 338751 391107 391109 338755 254786 254783 10798 390260 390261 219479 390142 219477 162998 390264 391112 390144 390265 109 391114 219473 390148 79501 286362 390072 390195 390075 390197 390077 219487 390199 392376 390078 390079 219484 219482 392138 127385 143502 119764 119765 143503 81050 390081 390082 390083 390084 26687 119749 26689 402135 219493 81168 81285 392391 81282 392390 504190 390174 8861 390054 26533 256892 390058 26532 390059 26534 26658 26539 26659 26538 26531 343173 390181 390061 343172 343171 343170 390063 441639 390064 389090 390066 390067 26664 343169 81061 2774 390190 390191 403274 127062 403277 403278 127069 127068 127066 127064 403273 120787 119687 81099 119682 26529 441933 127059 26648 120775 120776 119678 119679 390093 403253 392392 441608 403257 391189 26735 128371 26737 8590 128372 391190 196335 391192 346525 391191 391194 391196 391195 403244 128366 128367 128368 128360 119774 1262 119772 1260 26740 403239 346517 79490 81328 120586 256148 81696 81697 8387 8388 8386 8383 81318 79482 81448 81327 81442 132112 393046 8390 8392 122742 26494 26493 401427 26496 401667 401666 282775 122740 401665 26497 81470 81472 282770 341276 1879 122748 127074 341152 256144 127077 283617 120796 81469 119694 119695 120793 81466 282763 81341 343563 119692 387748 344892 79290 79296 135924 79295 26595 26476 284532 125958 442191 26246 442194 26248 442197 81127 26245 284521 135941 26339 26338 135946 26219 135948 26692 402317 26693 81399 26333 26696 26212 26211 81392 388761 343406 26341 9355 57101 51764 2782 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling 5533 2767 59345 3708 3709 5153 5534 5136 2769 84152 3710 5443 2771 2770 2782 346562 2776 5582 5580 2773 10681 5530 5532 5578 2774 5141 5143 5144 808 5519 5330 10645 5331 84254 5332 5515 5516 1020 5528 5577 111 112 23236 156 113 114 5137 814 115 815 5613 816 4988 817 2793 818 2792 2791 2790 2788 5321 2787 2786 196883 2785 2784 5573 2783 5575 51764 5576 107 108 5567 10768 109 5568 5518 5173 9630 94235 5499 5594 55970 5566 3838 26960 54331 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation 5699 9730 9554 154214 50489 151636 10952 80176 23194 9604 136371 10324 6279 10489 6271 200845 8454 6280 7097 6233 7096 7321 11065 8697 7324 10393 29945 29882 6810 996 695 51343 51529 8881 64682 7316 84676 27338 7099 929 80196 246184 51434 51433 23643 11059 8773 23291 7322 997 9871 7334 9632 7335 9861 5682 5683 10427 5684 8945 5685 5686 5717 8678 5718 5289 5719 7311 114907 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 22863 5694 5695 5706 5707 5708 5709 821 5687 5688 5689 5700 5701 5702 5704 991 5705 2209 89122 4615 3146 1514 1515 3107 3106 3105 1520 9978 51128 83737 3134 8673 3133 9341 3135 54778 10802 10484 8452 8651 84078 30849 653361 567 23327 1536 1535 7428 948 6502 7323 10333 6921 154881 7320 6923 23608 6478 7325 6477 131405 283807 221687 79654 26272 51088 9616 90678 7317 6396 56658 7319 10533 3093 26234 22888 7332 64750 9870 6468 7336 2923 10425 150726 64718 118424 23295 55336 7327 7326 9867 26190 197131 10273 7328 26270 4734 10422 54926 9520 65264 10193 10616 10075 142678 93611 127247 401036 79791 55294 55585 57520 51665 89910 7337 51666 55905 26091 22872 63891 63893 142686 57531 142685 55236 51676 142689 223082 10517 811 22954 8453 91694 10293 9666 51320 84261 80204 57542 57154 51444 5930 11146 135892 55008 6047 6049 26224 23376 23014 9246 5071 54461 29116 3551 57674 143279 57630 25793 84231 51191 11275 9320 4360 55819 1147 64410 90025 222235 8517 84937 7318 140691 3309 51465 54850 140456 140458 3693 90933 6890 140459 6892 3685 90135 6891 64167 25897 25898 51752 9690 2266 146330 140460 140461 2243 140462 255488 114088 54620 23352 868 8916 115290 6737 7704 55958 8139 390594 127544 55284 27246 2244 84961 8924 122769 8925 9021 64320 9354 81559 55175 84708 7174 27252 51130 642 51132 26046 9903 4591 25847 158506 92369 55182 126433 26259 114609 64219 7064 23304 201456 80028 144699 899 84861 92912 10477 26268 55070 90293 84727 92591 26263 26267 53339 285231 89890 4012 9820 4688 26235 26118 79176 4689 26232 55521 84085 4008 9817 51725 9039 25831 26249 8065 55658 55176 140739 9902 51619 29927 5721 9040 5696 148581 5720 79876 23480 79754 5698 84541 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD 1463 1462 10675 1634 9469 63827 633 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling 7316 5687 5688 5689 5700 5701 5702 5704 5705 5971 23291 1147 9861 5682 5683 5684 8945 5685 5686 5717 5718 4791 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 9039 5693 5694 5695 5706 9040 9020 5707 5708 5709 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair 197342 7516 10714 84464 7517 51426 63979 23514 80198 5424 55732 57804 79008 165918 10038 2067 79728 7158 5893 54107 54962 151987 5531 25 8914 54145 472 6233 144715 5810 5932 11073 6117 7316 6119 6118 8341 8342 8347 8348 8345 8340 1111 142 9656 7334 10524 7336 7486 5429 5982 5983 84126 2237 85236 8349 7311 7314 7979 5984 3978 5985 5883 8290 5884 116028 7156 5892 4683 8370 890 8900 3364 6047 51588 10721 641 7329 6613 51750 63967 255626 10111 4361 3018 3017 3014 1763 545 51548 80010 672 29086 9025 5890 9156 8924 51720 5111 84142 9577 79184 5889 8970 1017 128312 83695 580 83990 7468 5981 2072 56655 7515 5888 5425 5426 348654 5427 10635 146956 675 3980 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism 2592 5236 231 2582 2584 130589 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism 5092 5053 883 80150 5860 259307 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 2810 10000 208 7534 857 7532 7531 7533 5170 207 10971 7529 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases 2984 79849 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination 4913 4968 8341 8342 8970 8347 8370 8348 128312 8345 8930 23583 94239 8340 252969 55766 26277 25913 65057 7013 3013 8338 7014 54386 6996 255626 79661 55247 85236 8349 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME 55315 2030 100 22978 4860 3704 132 4830 4831 64078 9153 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport 375 84725 51228 80772 57488 83850 23344 1201 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment 7316 7311 7314 148022 330 6233 8737 7321 7322 11035 3551 7323 329 7098 7334 1147 7335 7189 8517 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion 5478 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 4893 6654 10818 4915 3265 10817 627 5781 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System 3417 3428 245936 147945 245937 11277 245938 197358 6278 245939 5266 5068 4057 6279 51411 6037 613210 116842 7100 613211 245930 728358 4758 245932 6271 245934 671 503841 641517 475 613209 55600 400830 10855 5657 51248 10578 130120 2588 729230 4069 1671 1670 245940 6947 6280 338324 7097 7096 1191 55894 1668 57119 100133267 140683 140881 51297 920 5641 1992 57115 6556 6039 128859 1669 245913 8993 503618 503614 245911 122665 23220 117285 80341 1235 114770 5660 1113 114771 1673 140850 1672 538 417 6406 3934 245927 245928 245929 81623 84659 3347 3346 820 149954 117159 644414 5646 92747 504180 6515 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 2171 11047 10213 5713 5714 7979 410 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 3958 5700 5701 5211 5702 5704 5705 427 5580 9261 3312 7184 5223 78989 5591 1432 3304 5600 327 1378 5236 51428 83737 5775 5567 5568 4893 3265 56729 1675 3004 629 718 2547 2665 7525 10890 7323 1727 5873 11031 58485 9218 7520 374403 22931 2990 93100 3074 411 2720 9246 64135 3551 23586 51191 1147 8517 4831 9636 7318 28988 7706 2934 161 2147 4846 710 26052 51728 2266 27297 1785 4860 661 10623 171568 1759 2243 84265 55703 55718 2161 11128 10622 5519 10621 5515 5516 5627 5528 57126 2244 3827 3273 5269 143662 5328 118430 5329 5049 4582 5199 4583 4584 4585 4586 200958 4311 727897 5795 10071 94025 55593 140453 4588 4589 2220 283463 1401 8547 3101 10584 394263 2219 978 5611 51316 5724 6616 5777 5295 5296 2358 5290 5291 23200 79895 240 155066 9114 5603 7321 4790 8826 523 525 526 527 528 529 5970 3163 3162 127124 23545 51382 5336 533 534 535 50617 8767 57506 7334 7335 7462 245972 245973 9868 51071 9641 5289 3661 9550 23250 3654 14 3656 2357 8992 90423 976 4048 10396 10312 5170 5894 9296 51311 3665 3442 3441 3440 114548 3439 2268 917 3055 6850 3080 4179 2209 3452 1361 3451 1380 10877 10878 3449 2534 3448 2214 730 2212 29110 731 27202 3326 3446 732 3445 975 733 3444 713 84166 92610 735 3443 51135 714 89122 4214 81494 10392 4615 715 79671 717 3456 3078 246330 3075 9097 1370 3146 3426 6285 1369 6288 11274 966 727 6283 9683 728 9684 1604 4793 729 28512 57161 5315 57162 177 178 23118 121457 28511 80216 3107 54106 3106 53831 5648 5781 22914 3482 9402 3937 7305 3822 3824 54209 51125 84282 81567 2512 6885 3133 8673 2495 8907 2717 5878 7187 290 7189 84061 80143 10159 1522 340061 84658 8651 51284 1650 2760 10454 30849 1 5534 81844 4973 1476 64127 26007 94103 567 2352 10695 196527 59307 6727 11213 127829 5589 9761 3240 79930 3615 3614 1084 5530 284266 4153 5532 89777 5788 6317 7415 5004 56888 5005 8514 326624 84443 4791 5036 9447 257397 4210 24145 387921 58484 222487 9051 29108 22861 6300 7294 351 808 10910 10628 5027 834 258010 26578 5912 23071 84418 2896 374395 1116 5908 64170 1143 387263 93978 6836 83716 1938 160364 23218 5553 1915 5547 25840 56954 10533 64581 3093 64114 57826 10694 9961 10576 25801 8635 10321 51646 12 9522 9535 10075 6036 9545 998 55 25798 25797 23593 79132 3809 170506 26253 3810 3813 8288 9145 22954 84514 3848 79169 2519 22875 54472 829 54476 5473 201294 80301 10875 10857 3043 114790 124583 2919 388698 388697 830 338339 4332 10493 4353 3579 353189 11322 3577 5870 23317 55754 11333 2683 170482 10462 55313 6590 3725 5273 199675 5284 401258 7006 23352 10394 150372 100049587 6737 3916 1794 3920 50856 51719 57020 5598 1774 64145 53916 53917 1315 10549 8972 2207 2206 2205 1118 2204 932 9844 2215 63916 1398 116844 1793 5879 963 965 967 968 387 51606 7879 4843 5768 8876 5062 8804 5787 5799 8836 23406 4282 4025 566 9039 4033 8887 1072 9725 10562 3702 302 441864 1265 84329 9040 54918 29952 154664 54941 6286 7130 6282 175 10043 9342 197 51806 83858 22918 51816 84766 11035 3608 5806 1687 51231 1849 1848 1846 1845 4627 80331 7226 8649 5581 4651 4644 196051 84513 4620 4641 7099 929 8772 121260 7186 6518 353376 23643 148022 5971 28956 841 8737 7322 997 10892 3689 4067 84433 5588 4792 10235 115727 5608 10125 8915 1075 2353 3384 55860 1823 1512 55004 835 10120 5906 5317 1386 5594 843 5595 5604 9140 6654 9474 79792 842 338 5300 4842 3310 634 2799 4361 2444 3553 719 317 5834 9020 3606 5836 8621 7133 7098 9798 11240 57554 4125 4126 5476 683 8976 6093 210 1832 10970 221 56667 226 1828 230 3929 10788 8566 10787 8560 5478 51552 7157 5175 383 8895 1460 3685 272 9588 708 4650 4771 6709 11001 4775 5747 5023 5880 79888 7276 8398 11010 5320 2821 4690 7295 122618 4688 55845 4689 8694 2040 23646 8936 5337 5338 64333 57153 147179 3708 51143 3709 3710 10006 23526 6793 10555 8904 10458 10451 10577 55832 7410 5335 29099 10109 8454 8655 23412 6233 7409 3320 1778 203068 695 10552 8987 7316 3071 10133 10383 79980 8773 23291 10093 10092 10095 8778 10094 10097 10096 3385 6402 8945 10768 80184 7454 27180 5518 7456 7311 124599 7314 6500 342510 126014 100132285 5566 11026 9436 5058 596 598 5864 5663 5063 54210 391 644150 55276 26999 3903 10288 2 51209 930 1509 1508 1514 1513 10152 1511 3818 1471 1991 23385 1515 7077 71 9846 837 3015 838 81619 6386 1520 823 10163 836 1729 25852 54509 960 5869 10810 64386 961 115004 684 51295 101 140885 102 4257 5645 138050 10326 4317 4318 158747 8411 4064 80231 3932 3663 3684 51082 9450 5094 653361 1536 1535 353 23601 3728 25 712 716 721 9533 722 54145 725 26 948 23191 8331 8337 23197 8334 3984 8335 51517 10333 30 4772 4773 8341 8342 8347 8348 8345 8340 47 1387 60 8338 5265 6778 85236 8349 330 1660 1654 1540 7128 329 81030 2033 81622 8370 6993 10010 2950 3013 10487 2517 6197 6196 6195 4205 4208 255626 10450 79155 5440 2002 5599 5441 9252 1326 5609 3021 80142 466 6416 5601 11314 7867 5602 7414 5606 3018 3017 3014 5434 5435 5437 3837 7448 2992 9208 474382 23114 8970 128312 30835 8968 4718 114609 3687 3683 945 4680 81793 2548 1088 847 653604 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism 284161 51573 133121 79153 375775 10908 81544 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs 55247 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 7316 378884 2990 6888 4669 3373 2632 3425 411 2720 92579 3423 51181 3938 7957 6476 2538 2799 2548 2588 8908 7311 2542 7314 3795 22934 6233 138050 229 2998 2997 2992 5507 6448 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions 8218 1212 1785 1213 2697 1211 1759 1601 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 54675 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 3791 7424 2277 7423 2324 7422 2321 5228 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism 5476 2760 4074 112937 5660 3074 3073 79642 79411 411 2720 153642 89944 2581 427 2717 4758 10825 4759 339221 55512 2629 347527 22901 57733 25870 285362 340075 6610 410 6609 412 414 56624 57704 415 416 55627 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6128 6129 22794 6201 6142 6203 6202 6141 6144 22916 6143 6146 9939 6147 6139 4686 6138 6152 6155 65109 6154 6210 6157 6156 9775 6159 6158 51065 200916 6205 10921 6164 6204 6166 9045 6207 6165 6206 55110 6209 23708 6168 6208 4116 6223 26019 6167 6222 6169 6224 23521 2107 6160 6161 65110 6233 6218 6217 6175 2935 6176 6171 6170 6173 6181 6230 6232 6231 6234 6235 6227 6229 6228 5518 7311 5520 11224 55802 25873 6188 140801 6187 6189 1981 5515 26986 9349 6191 6193 6192 6194 3921 6122 23049 6124 6123 23293 116832 6125 9887 55181 23381 55629 5976 56006 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 4851 5687 54567 5688 5689 2033 5700 5664 5701 5663 5702 5704 5705 3280 55851 83464 84441 9794 7534 55534 388585 4853 8454 4855 207 6233 22938 23385 51107 10046 2324 7316 8850 9978 4088 1387 23493 9861 5682 23462 5683 5684 5685 5686 5717 3516 5718 5719 7311 182 102 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 2648 5693 59 5694 5695 10460 5706 5707 5708 5709 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine 4913 4968 8341 8342 8970 8347 8370 8348 128312 8345 8930 23583 94239 8340 252969 55766 26277 25913 65057 7013 3013 8338 7014 54386 6996 255626 79661 55247 85236 8349 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 6176 8662 8663 6171 8661 6170 8666 6173 8667 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6181 6230 6232 6231 6234 6235 6227 6229 6228 7311 11224 25873 6188 140801 6187 6189 1981 26986 9349 6191 6193 6192 6194 1975 1974 1973 1977 1965 8894 1968 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage 836 838 3553 3606 79792 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 408 10755 7049 7042 409 7046 7040 7048 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I 7450 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism 83401 10005 3295 60481 6342 215 3992 2180 9415 64834 30 54898 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 23385 54567 51107 7534 55851 5664 83464 5663 102 182 4855 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling 7316 9021 6921 6774 6923 3055 6850 7297 7322 9616 1440 4067 3717 1441 6777 6776 6772 7311 7314 6233 7321 7323 8065 8651 3716 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 2549 5295 30849 5296 10818 5290 5291 3667 3480 208 2248 3479 8483 2255 2252 27006 8471 2323 3481 2247 2322 5289 2264 2251 117145 9965 54106 152831 5140 4893 9846 6654 57761 2254 5170 8074 2249 8660 3265 2246 8823 5781 8817 26281 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins 2155 2159 5045 2621 2158 2147 8858 5624 632 5627 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors 5468 4208 54715 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism 92370 9394 9653 51000 55501 222537 375790 337876 11261 4958 11081 10855 2588 266722 10861 9061 9060 2132 2131 347734 3161 2137 2135 6677 51363 56548 8692 6483 6482 6484 6487 10678 135152 8509 126792 4166 10090 64711 6383 166012 10082 29940 6385 8534 8703 6382 8704 4060 3340 8702 1462 2990 23553 3373 4669 8372 112937 3074 3073 3425 79411 411 2720 3423 633 221914 89944 1463 9672 4969 10675 27087 2239 60495 11046 92126 80146 10057 2799 2683 1514 55576 1634 3038 3037 3036 2262 2331 6548 1836 55454 5549 9435 9334 9331 64579 10402 2817 93010 9348 90161 9917 26035 63827 960 26229 55790 26503 79369 2719 176 9469 113189 3339 10331 9953 9951 284129 11041 79586 10894 64131 64132 23563 54480 11285 9957 9955 22856 50515 6448 9956 57214 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 7316 5795 8835 2322 7311 7314 10019 27 6233 1445 9306 84174 6503 2323 867 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair 5423 328 142 3978 2237 10038 8505 54936 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity 894 896 6714 5371 4343 192669 23112 27327 26523 27161 192670 57690 595 861 1021 865 5781 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 54716 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair 5111 6119 10714 6118 2237 5424 57804 5981 5423 328 54107 56655 5984 3978 5985 5425 5426 5427 5982 5983 6117 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH 2678 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex 4052 7043 4053 4054 2033 60436 50848 2280 3726 7042 57530 56937 56288 57154 23327 8425 9110 4738 51377 4221 7040 11171 7514 1874 23645 23370 3693 5045 3694 3685 5590 892 3690 25805 5494 25937 6233 8812 7321 22938 7027 3696 9958 7049 7323 5933 7029 7316 6667 6498 6497 5054 8239 5500 4087 4088 4089 1024 142 64750 4092 387 867 10273 51592 1025 1030 7311 7314 5499 7046 3065 1278 7048 54778 23439 5594 5595 7050 5501 8516 3688 9612 9040 9611 50855 4904 904 4609 1875 905 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis 10654 4047 3157 39 9453 91734 4597 403313 3422 2224 6713 2222 4598 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs 3815 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs 6801 3092 238 4869 5573 9451 27436 5495 2335 1213 57448 53335 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA 7514 5578 1994 8741 8125 5580 8021 6418 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse 388 9475 389 2064 79784 4627 23365 9826 4637 5364 10398 3984 3985 27289 103910 10507 6093 4628 4629 387 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 717 727 629 718 721 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells 7316 6457 4233 6456 8027 6714 7311 1499 7314 10254 6233 999 1500 79872 2060 9146 6455 30011 867 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation 166785 4594 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism 4750 7316 4289 64795 25852 54704 4199 54994 2954 1738 1737 10296 80232 5166 79018 3939 57546 5162 5163 7311 5164 7314 5165 64777 6233 5160 5161 8050 55066 10048 23409 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane 200894 22948 56623 6753 5147 27241 5310 5311 55212 117177 403 10013 6950 6010 7203 23265 92482 84747 378 60412 84100 54536 2847 6608 10640 4218 11336 129880 149371 1262 1260 10694 10576 1258 123016 10575 55763 79738 8729 166379 55770 79969 50807 8195 6102 8766 582 583 54585 585 27031 192668 9727 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions 7082 7122 861 100506658 865 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance 338 3990 26119 348 3949 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import 8528 1610 122970 3417 8309 26061 8540 196743 373156 1891 283927 5189 5190 5191 4358 54469 10005 2053 219743 51 6233 54677 7321 55825 5195 5192 5193 5194 5828 7323 3416 189 3155 23600 30 7316 11001 51268 3295 54363 8239 51179 7322 390916 1384 83752 570 1962 5264 55670 8443 4843 6342 7311 7314 847 8310 10901 26063 10965 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 7157 1263 9337 29883 10769 85456 25904 4850 23019 246175 4848 4849 995 5325 4869 7832 57472 55835 9125 55571 28984 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) 6844 9900 22987 9899 6843 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) 6844 6857 6843 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation 375 1175 160 920 161 163 51606 3932 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 3082 4233 6774 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs 240 246 5743 239 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants 5156 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 6888 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 5805 808 2643 3320 6697 4846 1719 207 5593 2644 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes 8341 8342 8970 8347 8370 8348 128312 8345 5925 94239 8340 55766 5347 8968 3013 8338 10592 10051 891 255626 3021 85236 8349 3018 3017 54145 3014 79648 653604 983 29781 8331 54892 8337 23310 8334 8335 8290 387893 6418 474382 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis 5687 5688 5689 5034 5700 5701 5702 5704 5705 10956 84447 55733 51009 6868 7415 6400 2262 6233 3549 27248 7316 50846 6469 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 85455 5708 5709 57758 147111 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 4851 54567 28514 3714 6868 102 182 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis 5111 6119 10714 6118 2237 5424 57804 23649 5981 5422 1763 5984 3978 5985 5557 5558 5425 5982 5983 6117 SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes 10714 5929 6908 129685 6872 54623 6874 6873 9070 23054 6749 6881 22976 6880 5430 6883 5431 6882 5432 56259 8148 5433 6884 80349 6917 4791 51497 11198 6875 4292 6878 83860 6233 4207 8812 1870 6877 4790 6879 58508 5395 2963 2962 5970 7316 5436 10538 5977 6921 5438 23168 6924 5439 4298 6923 8888 7975 85403 5971 7469 6830 138474 4300 8178 79447 5079 1387 3221 60 7709 605 6829 27125 55840 8110 5429 5982 6778 5983 6827 4602 9150 11201 1025 6601 2956 3394 6603 7311 51616 7314 6602 6605 25920 6604 54457 27301 51224 7936 5984 60468 5985 55677 604 1050 79577 123169 904 1875 905 86 6774 26039 4436 6760 11340 23404 5980 54512 10459 51455 144455 5440 5393 5441 23016 51010 51013 5434 5435 118460 5437 22894 56915 9646 79733 8289 9156 6929 5111 57492 10438 5394 10200 9274 9275 3727 2354 7403 57379 8193 5981 84661 11091 6595 5425 6597 6599 6598 8085 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis 7316 378884 5236 8908 2632 7311 7314 6233 7360 2998 2997 2992 5507 7957 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins 292 55746 293 23279 79023 10762 23165 6396 129401 9631 7175 3836 4927 3159 11168 8021 5903 9688 23225 55706 8815 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 291 79902 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis 688 6774 2033 8370 6256 94239 1053 2624 1441 3013 861 5914 865 255626 6688 3021 3018 1869 3017 54145 3014 7027 8331 8337 8334 8335 7029 474382 7913 1051 1019 8341 8342 8970 2672 8347 1017 8348 128312 8345 8340 55766 8968 8338 3570 4602 85236 8349 6886 1026 653604 1050 4297 2313 4609 51176 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking 8976 857 115677 4846 1785 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 11081 2799 112937 2588 3074 3073 79411 2720 2331 89944 4969 5549 176 4060 4958 EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle 7852 11168 2237 3981 2547 8815 3978 7520 920 3836 3159 1234 7518 5478 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle 7316 811 9695 6048 91445 80267 10206 56886 10956 267 84447 7844 10299 5589 55757 11236 51009 2923 55741 6400 7311 7314 23193 6233 11253 821 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense 2810 834 5292 2633 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants 238 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism 3248 8644 8529 4363 113612 241 242 246 247 158833 5444 59344 27306 1800 2877 10728 2876 1545 9261 1543 2879 1558 5445 1544 5446 2053 240 80142 1557 1559 2678 1582 1580 1579 1573 2687 145482 9536 5730 158584 873 284541 5740 5321 64174 2166 126410 57834 5742 5743 127281 4051 376497 4056 11283 4048 22949 6916 239 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors 133 10203 79924 3375 797 10266 10268 799 10267 796 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity 1735 1734 1733 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions 3684 58494 3695 1311 50848 1299 1298 999 375790 91522 3791 5175 3672 3693 3694 3685 2266 80781 3690 2243 3696 7448 2244 2335 682 2200 1305 960 3681 3682 3689 3675 3679 1307 83700 3687 6696 3683 3386 3673 3385 3339 8515 1286 961 1285 1284 3384 1282 3383 22801 3674 3676 3678 3371 1297 3655 3381 7412 7057 7087 8516 3688 4060 3680 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation 712 716 713 714 1401 715 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO 10055 6612 25950 10054 7341 59343 7329 29843 6613 205564 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters 285195 7781 23516 7780 64116 29986 25800 57181 27173 29985 283375 1356 64924 7922 7779 80024 57419 25769 4891 30061 123041 169026 9843 6548 808 55532 254428 6543 6546 6547 55630 84102 84679 6556 6550 6553 9187 389015 6717 6549 1317 283652 23315 10479 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter 51082 2972 6908 9328 9329 55814 5440 5441 9533 51728 27297 661 10623 171568 84265 5434 55703 5435 5437 55718 11128 10622 10621 112495 9330 2976 2975 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK 59345 94235 2793 2792 2791 2790 2782 2788 2787 2786 55970 2785 2784 2783 10681 51764 695 54331 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters 6561 26266 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion 164668 403314 200315 339 9582 10930 27350 29974 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle 5928 23194 894 896 902 5925 23649 5422 993 994 2801 5557 5558 79858 4149 57060 4292 472 1870 144715 5810 5932 5933 5934 11073 6117 6119 6118 4194 8317 22974 4193 1111 4869 4067 9656 10524 7486 5982 9861 5983 5682 5683 1263 5684 84515 5685 4172 5686 4173 4174 84126 5717 4175 4176 5718 64785 5719 8318 9837 84296 4171 11047 10213 51659 5713 5714 1026 7979 5690 5594 5691 5984 5692 5985 5693 5694 5883 5695 5884 5706 116028 5707 5708 5709 9212 5687 7156 5688 5689 4683 5700 5701 9184 5702 5704 991 5705 26271 890 8900 3364 4085 701 995 26277 25913 1616 65057 641 7013 7014 54386 546 55320 51773 8556 55355 11339 387103 7514 54069 5578 1874 4605 7534 11200 10111 8021 4361 207 3842 7529 1763 545 80010 1432 25946 672 387893 5600 6418 9156 5111 332 1452 9978 83695 580 5862 26003 8548 64151 10592 9918 23397 10051 1859 28227 1163 7468 260334 6683 9798 200014 347688 9088 10776 79648 23383 22933 10856 84930 2029 29781 55844 54892 23310 25836 5424 54433 27243 23165 1736 128866 55651 9631 7175 5430 5431 5432 5433 79643 1104 56979 55505 8607 51652 81876 8815 348995 9883 57122 1719 29082 5436 55746 1032 5438 1031 5861 5439 27183 91782 23279 25978 79023 10762 92421 6396 157570 114799 129401 4927 3930 5905 2237 5901 5903 9688 23225 23592 55706 3978 23636 9972 11097 23511 7083 8086 53371 8480 79902 1876 8468 1875 5520 25909 7341 9183 51588 9232 7329 51750 63967 57405 7157 1460 10403 1459 80776 1457 5519 23047 113130 9700 9985 5525 23244 27127 10734 5515 23063 5526 11144 5516 50511 5527 93426 5528 10388 29086 23626 5529 23345 9025 23224 91687 256126 51720 57551 90381 56158 79596 6847 84142 79682 51400 644186 9577 51451 23353 79184 29893 3306 27030 23175 84057 4438 4439 2010 2491 55143 9126 10735 10726 10274 64900 8243 1063 83990 1060 151648 5885 7298 728642 984 1058 9663 5981 56655 5425 5426 5427 348235 4609 675 10714 23421 51143 63979 55732 57804 64105 54107 595 5579 6790 8454 9662 8655 7840 6233 7321 11064 1781 25906 3320 22994 11065 22995 8697 7324 7283 10393 1778 10733 29945 80321 29882 203068 55722 996 84962 1454 699 51343 1453 51529 55125 8881 64682 5577 9814 140735 7316 27338 9738 119504 10133 3161 91750 246184 25936 11190 286826 1029 9793 132660 7532 55957 7531 51434 10383 51433 10382 23332 115106 79980 6232 79441 95681 23291 1069 54908 5500 5347 22919 54801 10142 7846 9702 10540 5108 4218 4659 11116 7334 4751 5048 55142 22897 891 54930 8945 151246 5116 9735 79959 80184 5518 93323 7277 9133 7311 7314 6500 23354 22981 8481 80254 983 121441 55755 220134 57082 54820 10806 5501 79866 10121 23141 5566 6241 55835 55559 6249 8636 11258 84131 4957 54821 23122 10971 3326 55920 11243 2810 91754 140609 10783 63922 79075 79991 80169 100134934 54921 2305 11130 63943 51512 55839 1028 8379 55166 79019 79003 4926 114791 55055 85378 10426 27175 653784 10000 81565 29922 27229 440145 10844 80097 147841 29935 10926 55388 401541 5931 7533 165918 7153 7158 94239 378708 1780 79172 208 27436 25 64326 1783 83540 80152 54145 3619 64946 6502 8331 8337 8334 8335 1022 8341 8342 8347 113457 8348 8345 8467 7280 8340 8338 7336 10376 23243 25777 5537 80086 64689 85236 55291 1062 8349 51807 8615 10381 22822 91768 112714 201254 55135 990 80119 51053 55164 5000 84790 5001 7465 23595 8290 23594 81620 7015 2932 4998 4999 51230 84617 10112 4331 9493 2033 898 347733 8370 9134 7278 79861 81027 81930 3717 3013 84643 3796 255626 5440 5441 3021 3018 3017 1869 3014 5434 5435 7027 5437 1871 3837 7029 7443 11004 255919 221496 474382 23399 8924 1019 5889 8970 1017 128312 1027 55766 8968 5753 80028 1021 1030 3065 653604 4001 5888 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) 6514 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines 196743 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 54492 4851 7316 54567 28514 57534 7311 182 102 7314 9148 142678 6233 3714 6868 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle 9138 5295 389 23365 399693 23002 392 3998 11214 6793 396 5585 5586 55219 64283 91452 23092 10211 3728 4983 857 7410 54443 5825 9826 81624 90627 9828 8826 6811 10395 708 4650 55701 114793 7037 2909 55914 9217 4162 128239 1729 4168 80728 55160 284119 91010 9341 57580 613 9743 57584 6093 394 29941 387 115557 3930 93663 6242 9475 55789 81839 9748 29 2040 11113 2319 23263 9639 7112 29127 7984 9414 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP 4148 197 718 375056 348 7018 5589 57719 255738 721 1000 351 7425 80341 3569 3490 8542 116519 26085 5265 354 213 3895 10970 7466 6383 10232 8074 4241 1462 4052 5034 10130 2519 338 8720 3915 3486 1435 4221 3912 3485 11167 3483 51246 54757 8404 3491 91851 3489 7184 3488 3487 2153 64856 10117 3816 813 2147 1114 1511 258 2266 7857 5954 3817 56955 29106 3270 10272 265 2243 1471 401138 5069 51280 3053 56975 57104 60676 3956 4924 7076 8614 4240 174 54972 3698 5624 84141 9210 11098 54587 462 5179 3827 51156 5340 10618 2621 6694 334 2335 2200 3479 1356 2719 2999 6696 652 3481 3913 5768 3371 11320 102 4312 1758 4313 3484 5611 335 336 147111 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina 64900 5578 23175 2010 9663 983 4001 23592 255919 221496 23399 891 5579 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics 1544 1576 1565 1571 196 64816 29785 54905 1557 9915 1559 1555 57491 1553 1551 1572 1562 1543 405 1577 1549 1573 1548 1558 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD 1738 593 594 1629 152926 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus 7316 23421 5599 8878 5664 5663 7311 4804 7314 6233 23385 4803 51107 55851 83464 7189 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 3032 3030 3033 34 1892 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B 26154 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 4802 6907 57678 8648 6256 8720 5465 96764 4597 10499 51141 31 3638 23054 32 3422 7108 4598 10654 79071 3837 79718 6309 1717 4520 3157 6667 51128 51360 9453 10498 1387 2224 9871 1595 6713 9632 2222 10427 4047 5469 85441 6319 5901 2194 80205 6721 22937 6604 10802 10484 4800 4801 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome 842 5594 5595 56616 51074 54205 55075 317 331 22900 57099 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs 5156 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors 5567 5568 51085 5566 5207 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 9990 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis 2931 5987 5594 5595 57674 1511 6421 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein 7341 1452 54956 3276 83666 84875 2931 56965 6733 7329 54625 143 6732 2932 79668 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) 4683 142 2237 7515 10721 10111 5932 4361 10038 5893 675 3980 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer 4088 7046 7040 7048 4087 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair 7516 7156 5892 4683 79728 4436 3364 641 79661 55247 10111 4361 4292 472 1763 545 144715 80010 5810 672 5932 5395 11073 5890 9156 6117 6119 6118 4913 4968 5889 83695 580 10524 7486 5982 5983 83990 84126 2956 4437 7979 5984 5985 5888 5883 5884 116028 10635 675 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion 5928 26508 23478 5931 5925 4613 94239 4343 192669 5589 23112 27327 26523 27161 192670 57690 1009 9789 3728 23193 54145 7020 6233 27085 1500 3170 79872 10399 2060 8331 117581 7750 8337 8334 8335 7316 8341 8342 6667 8347 8348 8345 4193 8340 8338 9743 9861 5682 5683 5684 5685 5686 283106 9314 5046 9159 5717 288 85236 5718 5719 8349 1499 7311 7314 11047 10213 5713 5714 60559 7979 7291 54737 5690 5594 5691 5595 5692 5693 5694 7088 5695 5706 5707 58505 54971 5708 23028 5709 821 5687 5688 5689 5700 5701 60436 8370 5702 2146 5704 5705 100128731 6663 999 51129 23396 3013 6591 11171 255626 1508 1495 5045 3021 1514 1460 6185 7414 116092 3018 1785 1459 94234 3017 3224 6615 5315 3609 6184 1457 2294 3014 10009 6935 27319 28972 56978 93986 55810 687 9839 348262 746 1520 387893 8289 1603 474382 7841 6929 8970 6714 128312 1488 1487 55766 1006 8726 8968 6938 23411 7764 90701 29954 64403 10585 80332 80149 7490 3066 3065 8728 28513 653604 3703 6597 1650 23512 4609 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation 10768 5578 3791 3708 5921 3709 5335 5590 3710 808 4893 5580 5170 8877 3265 5579 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 5058 3674 7410 3678 1460 3685 8829 1956 3690 1459 1457 4684 5594 5595 5604 5605 3688 5879 3897 3680 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 23443 84912 23169 55343 11046 10559 7355 51000 347734 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis 4057 PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance 7316 341 346 338 7376 26119 348 81693 8029 55911 8435 29116 57552 51599 4864 6646 255738 3988 10577 10062 1175 160 161 163 7311 7314 1213 7436 1211 3069 6233 3949 23491 3990 335 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG 11343 26090 57406 747 221955 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 4057 6279 6280 338324 6278 3934 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism 4125 4126 4123 23324 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions 1565 1571 29785 1557 1559 1555 1553 1549 1572 1548 1558 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) 2990 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis 22845 2720 4597 5373 10610 81849 4351 338596 29880 51046 256281 8128 4758 29906 4759 207063 197258 7264 8790 29926 29925 2762 5372 57171 282969 10402 140838 84620 55907 55808 5476 6489 10020 54344 54187 80896 7903 55343 129807 79644 26503 6483 6482 6484 10825 6487 116150 8869 64841 6480 79947 55577 256435 2673 6675 27090 5973 51005 5238 9945 3098 10559 30815 8813 8818 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling 2247 10818 2264 2251 9965 152831 4893 6654 2254 8074 2249 3265 2246 10817 8823 5781 8817 26281 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB 7316 8878 7311 4804 7314 6233 3654 4790 4803 8767 3551 4792 7189 5584 5970 4615 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases 10319 5802 8471 7422 51231 1849 1848 135 1846 1845 5156 80004 3178 54845 4670 3187 2251 23543 7073 7072 5725 1500 6236 2060 3399 5581 5140 4066 5792 8941 3416 8061 10221 4664 4665 1959 3398 23237 1961 1960 7425 429 253260 11059 1111 4067 4915 8851 627 7074 2353 7039 4058 10188 5046 1499 7057 2889 673 2475 5906 1386 5594 5595 1399 5604 5605 6654 2254 8074 2249 2246 10817 8823 8817 26281 10608 3726 79109 11033 10750 3925 2241 10076 8483 1447 5580 55615 3630 9261 3315 5578 2322 6692 3249 4485 4486 10653 64223 207 7529 1432 57761 5600 51072 6446 83737 581 3673 5867 53834 5567 5568 2562 2561 2560 5978 4893 2554 3265 161742 200734 5921 2567 2566 55879 22916 4686 7525 5430 5431 23163 5432 5433 2963 2324 382 2962 1003 5436 5438 5439 6093 2904 222584 8503 10273 25920 3815 4916 4908 5664 5241 2099 3397 55851 83464 10787 1495 6456 1175 2152 160 3685 161 4846 163 26052 4914 3690 1785 1213 117145 1211 1759 10126 4803 51107 5519 5515 5516 5528 11140 55914 5747 6714 2591 5327 64759 84951 6722 6387 7058 3727 200958 2354 2247 4690 5795 6464 116 117 4688 55845 10254 23768 4689 23769 23767 3400 3688 8936 285016 3561 4192 389658 4609 3718 29126 238 5777 3708 639 3709 5295 537 3091 5296 10818 2185 5290 5291 5764 4613 3710 3667 5803 10006 9306 10458 10451 2887 3643 5579 7410 1950 5335 155066 2064 5590 1956 9114 5899 25759 51741 6014 6016 5603 6233 7409 5900 1287 5800 3320 8874 523 5125 525 526 527 528 529 7316 3071 7059 80310 127124 7060 23545 3083 51382 256076 533 534 535 50617 1286 1285 245972 1284 245973 10768 1282 5518 5289 7311 9550 7314 81610 58513 10252 131873 14 5796 8038 1293 26018 1292 8992 29924 1291 90423 84985 55824 5774 5566 10312 5170 9296 8440 5058 6774 5663 5063 3914 1215 3915 3918 1299 1298 26999 2534 6868 3911 3912 10253 8569 5155 2323 5159 1509 857 6285 5045 10152 1958 2264 23118 23385 9965 54106 10755 152831 7049 9846 4209 2277 57610 255324 10048 5781 7166 10163 3730 5340 9402 1729 7424 7423 3479 6696 10810 2670 6772 9475 8027 1297 8829 102 3909 1742 10000 4318 8651 8660 3932 30849 348 653361 57498 208 1536 1535 2242 2885 1108 2321 5228 3728 9047 6461 3791 2886 6300 808 23191 1445 9101 4145 1020 26469 6455 3082 6457 5908 4233 85440 2549 374 9982 83888 2248 2255 2252 27006 143282 6777 6776 6778 4734 10019 10193 998 284217 30011 2033 3480 8828 3717 8877 6197 53358 6196 6195 4205 4208 2002 5440 5441 9252 466 7867 5434 5435 5437 7006 1795 10413 5607 5598 8841 9542 53916 10603 3084 2069 5829 25942 685 9564 9844 63916 3675 1398 6938 10718 1793 5753 1839 5879 5770 9146 5771 387 51606 867 3908 1786 3481 145957 3913 3910 3185 5062 5898 5782 3066 3065 8065 9611 558 6678 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET 10319 6774 5295 3914 5290 3915 3918 3911 3912 23163 6456 6692 3249 10653 6233 2060 9101 382 57610 10048 6455 5781 7316 53916 3082 5908 6457 4233 85440 2549 3083 5747 6714 64759 84951 3675 1398 5879 200958 3673 5770 9146 5867 5771 3908 867 3913 5795 3910 8027 7311 7314 3909 10254 2889 5906 26018 1399 4893 284217 6654 3688 3265 30011 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 7485 51608 3162 7917 439 6844 10952 6449 9381 2010 351 5621 9218 6811 27230 6804 8266 23480 819 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 7316 5687 5688 5689 5700 5701 5702 5704 5705 9861 5682 5683 7157 5684 64326 5685 5686 5717 5718 5719 7311 7314 11047 10213 472 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion 7316 137492 27183 91782 25978 51271 23327 27243 55048 92421 128866 89853 10015 51160 155382 5478 93343 7251 79720 79643 51652 7311 7314 6233 51534 9525 51510 29082 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D 7316 5687 5688 1019 5689 5700 5701 5702 5704 5705 595 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 2932 5708 5709 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 7156 7516 5892 83990 5889 4683 10111 4361 79728 472 1763 580 80010 5888 672 641 5932 116028 10524 7486 5890 10635 9156 675 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide 759 11238 23632 760 761 771 762 763 765 377677 766 768 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation 5436 6921 5438 6924 5439 6923 7469 8178 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 51497 11198 25920 5434 5435 51224 5437 7936 2963 2962 904 ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes 5111 7316 10714 11201 2956 7311 7314 4436 4292 6233 5981 5984 5985 5395 5425 5980 10459 9156 5982 51455 5429 5983 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence 5928 8370 4217 5931 2146 94239 4343 192669 23112 27327 26523 192670 57690 3013 9261 255626 7157 3456 5599 3021 5609 6416 5601 7867 5602 3018 5606 1869 3017 54145 3725 6233 1870 3014 7027 1871 1432 8331 8337 8334 8335 7029 5600 8535 474382 7316 1019 1032 8341 1031 1029 4194 8342 8970 8347 8550 6045 8348 128312 8345 8340 648 4193 55766 6015 23466 8726 8968 1912 1911 8338 5608 1021 80012 57332 84733 2353 23043 85236 7295 1030 8349 7311 7314 50488 9448 653604 5594 5595 23135 23512 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins 1025 904 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription 4851 6772 84441 9794 26508 2033 3516 55534 8850 388585 2173 4854 22938 3280 23129 23286 1387 171558 2648 9787 23493 5087 10046 23462 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria 7157 7027 5366 7029 1869 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 6523 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 7316 7099 10454 929 353376 7311 257397 23643 7314 148022 6233 23118 6885 3656 7189 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway 5058 3708 5921 3709 5295 5296 5063 79109 2185 5290 5291 653361 3710 10006 26999 208 2534 1536 5580 1535 55615 10458 8877 9261 10451 10787 3315 3728 9047 5579 6461 5578 3791 857 1495 7410 5335 3685 4846 5590 10152 7867 25759 3690 64223 117145 207 5603 7409 6300 3320 1500 808 23191 1432 57761 5600 1003 10163 3071 5747 253260 5829 9564 9844 63916 1398 1793 5879 10810 6093 387 4690 5567 10768 5568 9475 5062 1499 4688 55845 4689 998 2475 10000 4893 5566 5170 8936 3265 558 8440 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 11081 4969 5549 176 6487 4060 2331 4958 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation 84570 7373 9313 136227 1299 1298 4323 1305 1303 4324 1308 4327 1307 6868 1306 8754 91522 1310 85007 1509 1508 4320 4321 5045 164656 1514 4322 1297 1513 102 80781 4312 4313 1991 5645 4314 4316 4317 4318 4319 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex 57546 5162 5163 5164 54704 5165 2954 5160 1738 5161 1737 8050 55066 5166 23409 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle 5467 7069 5563 5565 58526 1374 6584 6256 1376 1375 788 51422 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin 3320 7296 928 3326 1839 1938 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade 2549 5295 30849 5296 10818 5290 5291 3667 208 2248 2255 2252 27006 2323 2247 2322 5289 2264 2251 117145 9965 54106 152831 5140 9846 57761 2254 5170 8074 2249 8660 2246 8823 5781 8817 26281 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events 5950 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 6176 8662 8663 6171 8661 6170 8666 6173 8667 8664 8665 27335 3646 51386 8668 8669 10480 1964 6181 6230 6232 6231 6234 6235 6227 6229 6228 7311 11224 25873 6188 140801 6187 6189 9349 6191 6193 6192 6194 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling 7049 3624 3623 92 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade 10454 64127 7100 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 51231 246330 2002 1849 5599 9097 1848 9252 3146 1846 6285 1326 1845 6288 5609 11274 466 6283 6416 9683 4791 5601 9684 257397 7867 8454 4793 5602 28512 5606 57161 3725 57162 6233 177 23118 121457 351 4790 28511 80216 5519 1432 5515 5516 5600 5528 5598 5970 7316 7186 23291 841 6885 8767 4792 5608 7334 7335 7189 2353 8945 81793 5518 51295 7311 7314 6500 3654 3656 5594 1386 5595 5604 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated 5518 1452 1499 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis 5464 27068 64077 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation 51082 4784 2972 2971 4774 6908 9328 9329 5451 10302 55290 55814 5440 5441 6621 6619 7702 6618 6617 9533 51728 27297 661 10623 171568 84265 5434 55703 5435 5437 55718 11128 10622 10621 112495 4781 9330 4782 2976 6741 2975 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants 6772 6774 5295 5290 8805 1523 613 9846 7750 26127 11116 11052 399687 6777 6776 9208 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing 8106 10898 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD 4143 VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 5928 5356 9968 3188 3184 9969 902 9716 3192 5925 3191 3190 8896 4061 6238 10084 9789 8449 23350 9343 56259 22924 80349 10945 10946 10949 10907 9360 7097 10914 7096 80306 1191 9382 27339 4939 83443 920 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 3312 7514 7534 8021 1981 207 7529 1994 26986 54464 3304 1452 9978 83737 6122 6124 6123 6125 6886 6130 6133 6132 6135 8452 6134 6137 6136 6128 6129 6142 6141 6144 129685 6872 22916 6143 6874 6873 23327 6146 2547 6147 27243 55048 6139 23165 4686 6138 128866 89853 10015 6152 6749 6155 9631 6154 7175 6157 6881 6156 6880 5430 6159 6158 6883 5431 6882 5432 6164 6166 8148 5433 6165 6884 7852 6168 6917 6167 79643 1104 6169 51652 51497 6160 11198 6875 6161 6878 83860 8812 6877 51534 6175 2959 6176 2958 6879 6171 8815 6170 2957 6173 348995 9883 9525 57122 2963 2962 2961 1234 2960 29082 29959 5436 55746 6921 5438 6181 6924 137492 5439 6923 27183 91782 23279 25978 79023 51271 7469 138474 10762 4088 8178 4089 92421 6396 8732 142 7520 129401 8731 112950 51160 6829 3836 4927 3159 7518 155382 6827 9397 93343 9150 7251 5905 79720 2237 1025 5901 5902 51616 5903 3981 9688 23225 25920 54457 51224 7936 55706 3978 23636 9972 11097 23511 8086 53371 8480 79902 51510 904 4904 905 4836 1312 9246 64135 3551 23586 25820 51191 1147 8517 9636 7318 3309 7706 1175 160 161 2147 163 1213 1211 5627 5610 116832 22937 3688 5611 3843 10965 2926 3718 5777 5295 3437 3434 3433 11267 51028 84313 861 476 7040 477 200916 478 53822 53826 219541 53828 4790 480 481 482 483 486 5970 6667 5336 6230 6232 6231 6234 64398 6235 63982 253832 6227 6229 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 7335 64601 79760 6480 10427 256435 27090 9868 9641 11282 8678 5289 3661 29801 85437 81631 51304 3654 55107 5348 3656 5349 91662 6383 10082 6385 7113 59272 22863 5170 6382 143 58505 2697 51311 79668 821 3665 27072 3442 3441 3440 23367 114548 3439 2280 2589 23389 51201 54956 100128731 55129 3055 10971 10610 6850 221914 9672 3452 3451 10800 2239 3449 2534 3448 29110 3326 3446 3445 26762 3444 54960 3443 89122 10392 84818 3456 3454 55823 857 6607 8487 6185 6188 6187 4793 6189 2262 23479 6184 23118 121601 2931 2810 3107 54106 3106 3105 6733 11253 746 54625 51114 6732 2817 5648 1603 5781 6632 10053 7841 9349 203859 6191 6193 6192 7284 6194 57101 26276 51125 162 51128 164 65082 84282 6628 7297 23339 6885 338440 3134 3133 9685 9908 6634 6633 2719 8907 6636 6635 8905 10146 5878 3921 6637 7187 7189 84061 130340 6773 6772 80143 55741 1174 79833 3135 11320 8829 7991 92359 340061 4245 4124 3276 11218 10802 56965 201595 10484 10000 3703 50628 2197 7082 23765 3716 140032 3838 1655 51284 1650 4247 4249 10454 50636 6441 6201 30849 6203 6202 7533 64127 26007 25834 567 83666 196527 84875 79844 5589 57719 208 11311 3615 375790 7405 3614 3605 6210 112744 4153 25929 25921 51065 7415 6205 6204 6207 6206 6209 6208 6223 6222 7555 6224 257397 23193 10207 2530 7428 29108 6218 6217 57617 834 4780 1915 7317 10533 23028 55236 10362 51317 3717 22938 23352 23186 1794 9844 5879 51606 3181 3185 5062 2194 6627 9817 9039 8065 79876 9785 6430 6432 6431 10250 51362 199746 6427 6426 6429 6428 11035 197259 10189 8683 9775 9295 10921 11338 7307 3178 4670 3187 5725 7099 929 23643 253260 8737 57521 4869 4067 4792 2475 6654 5034 79109 1616 55615 140801 64223 55588 81857 1974 5371 1973 1977 8106 7098 5868 5978 51121 317772 85235 25855 221613 92815 8969 23521 440689 5926 292 293 6093 55763 8729 27316 5499 7353 55666 7341 2908 7329 9412 5478 1460 1459 1457 9441 291 57551 51586 10951 2288 4690 10134 400569 51143 55090 23097 3459 3460 9045 1956 8655 6233 7409 1781 3320 1778 203068 3183 695 140735 7316 7431 7532 8974 7531 79869 283208 5500 5033 4751 8945 5479 7311 7314 6500 5501 6837 598 10728 11224 940 5045 25873 1514 5824 1479 1478 1477 2342 2339 57794 5869 317649 1052 11100 10262 54797 90701 3339 10236 5593 4131 23524 115004 57703 9475 684 689 51185 1901 4318 23020 9862 85313 9879 335 9410 11051 9416 3932 10181 51585 6908 6907 57504 23476 23478 5093 5094 51593 5931 54623 404672 84844 1982 1993 1524 1780 1107 8175 8189 51503 1108 23601 9076 55690 55696 1783 11168 712 54815 716 721 722 725 4666 4691 53615 56949 375 8331 5546 8337 8334 8335 1022 10332 10333 7301 84246 5119 10313 5133 54344 51639 8341 23168 8342 8347 8348 8345 51645 8340 79685 8672 9532 1024 1387 8338 10291 10294 9443 51692 11123 2923 9442 10280 10283 25777 9440 8241 51234 10286 10285 85236 9111 8349 29760 10155 9439 1660 60559 1654 3839 1665 10284 84991 3840 3841 2521 64426 81030 81608 79577 2932 10898 30011 55339 57459 123169 10421 811 4331 2033 285755 8370 51003 2146 22826 22827 6993 3480 9219 54883 9477 9112 3013 11325 90390 55749 4360 8819 23451 64225 10025 54431 255626 10450 5440 2002 5441 10461 10465 11314 2966 892 2965 3018 3017 54463 3069 5434 53938 5435 28972 5437 23283 3837 79718 440400 24148 7448 2968 9646 2967 53981 51340 8841 57461 10001 27238 29894 815 8970 2621 816 51726 128312 51729 817 818 2633 402569 2071 80273 30835 2068 8726 8968 926 10992 10525 10527 945 29079 10523 10978 3554 2874 3570 973 5469 974 3676 9282 988 3066 3065 6629 653604 220988 51742 23450 8813 6638 8818 10594 91937 9612 550 9611 4736 23512 558 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM 166785 4594 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 2247 6657 57167 6299 6774 55211 27022 79923 5460 2041 6997 7547 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication 10714 29935 10926 55388 23633 5424 57804 94239 23649 5422 54107 5557 5558 8454 54145 6233 7321 25906 11065 8697 7324 6502 8331 10393 29945 8337 29882 8334 8335 996 51343 51529 8881 64682 6117 7316 6119 27338 119504 6118 246184 8341 8342 51434 8347 51433 8348 8345 8317 8340 8338 3836 9861 5982 5682 5983 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 4176 2237 85236 5718 64785 5719 8318 8349 9837 7311 84296 7314 4171 11047 6500 51659 10213 5713 5714 7979 92667 246243 9941 5428 5690 5691 5692 5984 3978 990 5985 5693 51053 5694 5000 5695 5001 23595 5706 23594 5707 81620 4998 5708 4999 5709 5687 7156 5688 5689 5700 898 5701 8370 5702 5704 5705 9134 890 8900 3013 255626 3021 3018 3017 3014 1763 3837 474382 5111 56652 8970 1017 128312 9978 6742 55766 11232 8968 5442 5981 653604 56655 5425 5426 5427 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 3589 6772 9021 3570 6774 5008 3976 3569 133396 9180 1489 9244 7297 3572 386653 1271 1270 3717 3977 3716 23529 5781 3590 867 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway 4790 10892 3553 841 29108 5970 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis 83729 2488 3626 3625 3972 3624 3623 5122 94115 5443 7252 1081 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins 240 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 3074 PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization 100287932 1678 122970 84269 506 51025 10952 3417 8309 131474 134266 26061 131118 79145 9381 196743 388753 10245 1537 197257 29928 51142 1891 26519 283927 26520 3421 516 10440 91452 1431 2053 219743 215 51 6233 54677 7321 351 7323 3416 3155 23600 30 7316 3162 293 3295 54363 90639 25813 51179 7322 390916 9218 5621 83752 570 8799 55670 54332 6804 50 84896 51024 11264 9409 9868 6342 7311 7314 3313 27235 27230 150274 10452 100188893 401505 56993 8528 1610 54543 6844 10478 9804 8540 373156 5189 5190 29090 5191 4358 54469 10005 5009 5827 10063 5825 55825 6811 5195 5192 5193 5194 5828 6901 189 291 8266 819 7485 51608 11001 10651 51268 7917 439 9512 5824 6449 54927 23203 3329 7416 8239 2010 80273 1384 1962 10165 5264 8604 4714 8504 8443 225 4843 847 617 8310 4580 10901 2671 26515 26517 2395 51287 100272147 26063 10531 400916 10965 26521 498 10469 56942 23480 92609 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death 598 REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway 2534 5649 7436 30011 1600 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 4088 7046 7040 7048 4087 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome 834 9447 29108 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor 808 2901 2899 83988 2898 2897 1741 2900 1742 1739 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis 3708 3709 3710 139189 9162 160851 5588 5580 10235 10125 1609 1608 747 1607 1606 8527 8525 8526 7222 7225 221955 5581 11343 26090 57406 57113 5583 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis 8708 2525 8705 2524 10690 30815 2529 124872 2528 2527 10317 6484 10402 6487 8707 2526 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins 7450 5908 3674 5747 6714 7094 2266 3690 2335 2243 54518 5906 6654 2244 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism 83401 60481 215 3992 2180 9415 64834 54898 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein 7841 5589 23193 4245 821 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes 51585 6908 51593 129685 22916 65123 57508 4686 80789 26173 55726 55756 64859 26512 23248 6880 25896 5430 80237 79035 5431 10302 6882 79664 29101 5432 5440 22936 5433 81556 6884 5441 6621 6619 7702 6618 6617 55656 79871 23379 54973 92105 6878 51808 8812 55174 6877 5434 57117 5435 2959 5437 55197 2958 84524 58490 2957 1022 2963 2962 2961 2960 5436 5438 6667 5439 8178 5451 5452 6829 6827 1025 904 905 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism 10568 6569 6441 5222 1755 221395 29080 51201 643834 9476 29995 51816 643847 21 136 150 152 135 2627 1512 10970 653509 6440 729238 6439 1439 1438 5029 7270 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses 8500 2911 6857 8825 5802 2915 8573 143425 2906 2905 2902 341359 23136 320 2892 2890 10211 1739 8496 2036 2893 28988 22865 64130 5792 85358 10313 9546 22839 26037 22871 9066 57502 57669 58512 127833 10611 91683 321 57596 26050 26045 2037 6804 2035 57555 2904 9229 57622 2903 9369 79414 54413 9454 57497 78999 9455 347731 347730 9379 6812 9456 22829 22941 80059 50944 55327 1742 11141 9378 81858 2319 8495 1741 4916 94030 1740 114798 8541 84631 8497 5789 84189 139065 8499 26280 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function 5687 5688 5689 5700 5701 5702 5704 5705 999 3728 1508 1495 1514 7414 1785 6233 27085 1500 79872 10399 2060 1520 7316 6714 4193 9861 5682 5683 5684 5685 5686 5717 5718 5719 1499 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 54971 5708 5709 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway 400569 9968 23478 9969 55090 1524 375790 9789 23097 1956 219541 7097 6233 80306 4691 3320 4939 10332 10333 84246 7316 7099 929 6921 8341 6923 23643 5500 1024 1387 57506 112950 9443 9442 9440 8678 3661 7311 7314 9439 5499 60559 6383 10082 6385 5501 6382 6837 3442 3441 3440 2033 3439 51003 23389 3480 221914 9672 3452 9477 9246 3451 2239 64135 3449 3448 23586 25820 3326 90390 3446 51191 9412 3445 3444 3443 10025 3312 9636 7514 3456 3454 7706 5045 1460 892 2262 1459 1457 28972 3837 55588 9441 2817 51586 10001 81857 5610 9978 7297 30835 5869 2719 7098 54797 90701 3339 5878 29079 6773 5868 4131 5469 10134 9282 9862 8065 3716 51284 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type 1463 1462 10675 1634 113189 63827 633 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 2767 11069 59345 6844 3708 6616 3709 6861 2769 2864 3710 2771 2770 2782 4082 2641 2776 10681 3630 150 152 5578 26251 8826 948 3745 5330 3747 5331 773 775 776 5577 777 111 112 23236 114 783 2793 784 2792 2791 2790 2788 3767 2787 2786 2785 2784 5573 2783 5575 51764 5576 6804 6513 3790 1131 2778 6514 5567 10768 5568 6812 9254 9630 94235 10411 5906 55970 2182 2181 6833 5566 2740 9495 54331 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity 842 5594 5595 56616 51074 54205 55075 317 331 22900 57099 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery 5436 6921 5438 6924 5439 6923 7469 8178 6749 6829 5430 5431 6827 5432 5440 5433 9150 5441 6917 1025 51497 11198 25920 5434 5435 51224 5437 7936 2963 2962 904 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation 2617 1615 2058 5859 6301 7965 3376 5917 9521 5464 9255 23438 57176 25973 3735 55157 80222 10667 79731 79587 51067 55699 124454 23395 7453 57038 10352 16 92935 8565 27068 54938 3035 2193 57505 833 6897 51520 4141 4677 10056 7407 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome 3767 10060 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling 3659 3665 5724 5777 7341 81603 3664 567 8554 10612 55128 4938 2209 4940 3717 51127 5580 85363 117854 23321 9830 3459 3460 10475 7706 79097 11074 4939 3107 3106 3105 23087 6737 115361 80263 4502 5781 2635 55223 9021 388646 163351 815 816 817 2634 818 2633 10379 5371 4684 960 3662 3134 3133 7726 115362 4092 5770 4261 23650 10346 4281 3383 8638 3135 3123 3122 3120 3661 3458 3394 3119 53840 3118 3117 3115 7412 3113 10437 5594 10107 5595 3127 3126 3125 8651 3716 3660 80128 5894 6672 4904 3663 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones 1388 3309 8720 51360 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification 4249 9554 51143 375056 25834 4253 1081 11070 1780 2801 79090 2890 4905 26958 1783 51014 10945 23423 372 381 8655 2530 27095 1781 9382 9276 81876 11316 375 377 1778 22818 1314 10342 54732 1453 51226 51399 22820 140735 7109 11014 22796 6399 5861 374 84342 91949 25839 378 51272 126003 83548 58485 57511 9527 6712 51693 6396 10466 10540 122553 9871 55738 6484 5265 8774 9632 1075 93661 23243 22870 2348 6480 10175 10427 10972 7039 5537 9117 55860 11196 64689 8729 288 83696 55291 11282 254263 25956 55014 81562 1639 63908 51164 8615 149111 9919 84516 90411 11015 10282 1294 26984 10671 79748 128637 89866 10960 10121 8703 22872 8704 11258 8702 6708 79694 6710 829 10113 10652 3998 64377 338596 51046 3972 4248 4122 830 832 8128 3630 2517 84364 23256 2153 2683 966 9570 57731 1604 6811 9334 287 10959 9331 51332 2157 6709 8775 2525 1315 6711 51128 286 2804 11320 1522 57134 4121 9486 4245 10905 4124 10802 26286 10484 4247 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events 111 112 156 113 114 5137 814 115 5153 815 5136 5613 816 817 818 196883 5582 5580 5573 5575 5576 107 108 5567 5578 109 5568 808 10645 84254 5566 3838 26960 5577 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants 238 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy 7316 200894 11315 10013 137492 91782 25978 8100 51271 27243 3043 55048 92421 123 128866 89853 10226 51160 3312 155382 93343 5116 7251 79720 79643 51652 7311 7314 6035 6233 1068 1080 29082 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases 347527 22901 79642 411 25870 153642 285362 340075 410 412 414 415 416 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism 57153 1757 55349 6583 23446 635 29958 501 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 2247 5295 2549 5335 10818 5290 2251 2248 4893 2255 2252 6654 27006 2254 8074 2249 3265 2246 10817 8823 5781 8817 26281 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants 5156 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations 55624 10585 1605 29954 146664 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling 2247 10755 7049 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters 10568 6569 6574 142680 6568 6575 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen 2812 7450 2815 2814 2811 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation 10454 64127 257397 7867 5606 23118 3654 6885 3656 1432 8767 5608 7334 9261 5600 7335 7189 8517 10392 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 54492 7316 4851 54567 26508 2033 57534 5664 8850 5663 3280 11060 23129 1387 3714 55851 23493 83464 23462 6772 84441 9794 28514 1950 3516 55534 2173 1956 388585 7311 182 102 7314 4854 9148 142678 6233 22938 23385 51107 23286 171558 2648 9787 5087 10460 10046 4904 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 6169 6224 23521 6160 6161 6233 6218 6217 6175 6176 6171 6170 6173 55364 1051 6181 1054 6230 6232 6231 6234 6235 6227 6229 6228 440275 7311 1386 468 10985 1649 11224 25873 6188 140801 6187 6189 440 57761 467 9349 6191 6193 6192 6194 1965 8894 1968 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events 5533 5567 5568 5518 5534 5141 5143 5499 84152 5144 808 5519 5573 5566 5515 5575 5530 5576 5516 5532 1020 5528 5577 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 3082 4233 2549 5781 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 9780 3678 3685 59284 783 784 3690 24145 8912 207 5027 781 782 6696 3688 3339 2697 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling 2280 29904 4343 51422 192669 23112 27327 26523 208 27161 192670 57690 92335 5562 81617 5564 55437 84335 6794 5571 1981 64223 5494 207 5230 7529 1978 8649 5563 5565 51719 64121 10542 6194 389541 28956 10670 1975 57521 153129 6009 1977 10325 7248 7249 55004 53632 2475 10000 58528 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 808 10645 814 84254 816 818 3838 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 113451 79814 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 7039 1950 4893 374 6654 2069 1839 1956 3265 685 255324 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 1589 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization 378807 117144 117155 79820 157855 57828 347732 257062 6677 928 22917 5016 49 100129669 57829 126123 2515 113177 7783 11085 2683 7784 284359 8747 8748 84329 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT 2592 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 240 8529 4363 126410 241 57834 246 4051 284541 4056 1800 2678 64174 11283 4048 22949 1580 9261 1579 2687 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 7316 5687 5688 5689 23194 5700 5701 5702 5704 9978 5705 80028 9861 5682 5683 5684 5685 5686 5717 5718 5719 6790 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 86 6601 6603 29117 6602 196528 6605 6604 60 6595 9274 605 9275 55274 6597 55193 6599 6598 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome 596 598 22861 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA 56603 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland 7039 5617 1950 2255 374 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease 5393 80349 23016 51010 51013 118460 22894 56915 11340 6499 23404 115024 9652 10767 54512 28960 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 5687 5688 5689 5700 5701 9184 5702 991 5704 5705 890 8900 4085 701 9232 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 7316 27338 119504 246184 51434 51433 5347 4751 9861 5682 891 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events 10818 4914 57498 2889 7529 673 4803 5906 5594 5595 1398 1399 5604 5605 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism 191 339896 1491 2806 2805 100131187 23474 25828 875 4357 84245 4552 51074 1468 1036 51380 4548 6821 4507 55256 84890 58472 2326 7263 58478 635 4143 23743 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle 80179 22906 66008 89941 55669 5910 9927 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense 7322 7316 808 163351 837 115361 7311 2634 7314 2633 6233 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition 5928 29935 10926 55388 902 5925 23649 5422 993 54107 208 5557 5558 595 4149 8454 6233 6502 5933 5934 1022 1719 6117 7316 6119 6118 91750 286826 132660 55957 8317 9861 5682 891 5683 5684 84515 4172 5685 4173 5686 4174 4175 5717 5518 4176 5718 5719 8318 7311 7314 4171 11047 6500 10213 5713 5714 7979 1026 983 91768 5690 5691 5692 990 5693 51053 5694 5000 6241 5695 7083 5001 7465 23595 5706 23594 5707 81620 4998 5708 1876 4999 5709 1875 5687 5688 4331 5689 5700 898 5701 5702 5704 26271 5705 9134 890 8900 1874 1869 207 7027 5519 5515 7029 5516 5111 1019 1017 1027 5753 28227 1163 7298 3065 10000 56655 5426 5427 4609 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) 4802 4520 6907 57678 3157 8648 6667 6256 96764 5465 9453 4597 10499 10498 31 32 23054 1387 3422 7108 2224 1595 6713 2222 4598 10654 4047 79071 5469 85441 6319 2194 80205 6721 6604 79718 6309 1717 4800 4801 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated 5518 1452 1499 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription 5925 85437 1655 7428 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 7978 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance 55911 341 346 338 51599 7436 MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase 5925 94239 23165 2801 9631 7175 5579 54145 81876 8815 8331 348995 8337 9883 8334 8335 57122 55746 8341 5861 8342 8347 8348 8345 23279 79023 8340 10762 5347 6396 129401 8338 4927 891 64689 5518 85236 9133 8349 5903 8615 9688 23225 983 5594 23592 55706 23636 9972 11097 23511 8290 8086 53371 8480 79902 8370 3013 255626 5578 3021 8021 3018 3017 3014 5519 5515 91754 387893 140609 5516 10783 7443 6418 255919 221496 474382 23399 23175 8970 128312 2010 55766 8968 5862 26003 8548 10592 10051 64900 10776 9663 79648 4926 653604 4001 84930 2029 29781 55844 54892 23310 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 9337 2033 898 9134 890 8900 995 7832 57472 9125 144455 7157 1874 29883 10769 6790 25904 4850 57060 1869 4848 4849 7027 2810 5325 1647 25946 79733 5933 7029 5934 55571 28984 5111 1017 1027 246175 10498 4869 581 891 1263 85456 23019 3276 1820 1026 983 55835 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex 84515 990 5000 5001 23595 23594 4998 4999 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation 9252 466 9261 6197 6196 6195 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 6907 644 6774 645 114548 8648 4363 6256 5465 96764 10499 3043 341947 23054 1327 3040 1329 1340 1337 1339 1351 1350 4697 1349 10628 79718 1347 1346 1345 9167 84701 8841 3163 3162 4512 4780 4513 7975 4514 25942 10498 1387 54205 55620 5753 213 125965 5469 85441 9377 80205 6604 2168 613227 9612 9611 81502 571 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle 80179 22906 66008 55288 5910 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation 3549 9759 2736 865 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function 26508 6667 4343 51129 192669 23112 27327 1006 26523 27161 192670 57690 1009 3728 64403 80332 1495 1499 3224 6615 3609 2294 8728 27319 56978 1500 9839 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity 5928 6908 639 5931 129685 6872 6874 6873 1107 208 6749 1108 6881 6880 6883 6882 8148 6884 5305 54815 6794 6790 11198 6875 6878 472 83860 6233 94241 79837 6877 117584 10419 53615 144715 6879 5810 5932 11073 1020 6117 7316 6119 6118 80196 4194 1029 8550 253260 22974 4193 138474 1111 8445 9891 9099 5608 10524 7486 8396 8851 5982 5983 1263 23368 84126 5518 7311 51616 7314 29117 64769 53632 54457 983 2475 5984 90809 5985 5170 5883 5884 116028 54971 51230 57459 9212 7156 4683 2033 7159 27154 10848 79109 133383 5300 79813 890 8900 3364 9219 7161 51422 26155 84289 1616 641 55615 7862 5562 5564 7157 204851 26013 56950 11200 1460 10111 4361 5571 7994 64223 1459 7874 207 1457 1763 545 80010 5519 1432 5563 5565 25946 133746 672 5515 387893 5516 5600 5527 5457 5458 9156 10919 23774 91875 28996 1017 8626 6446 83695 5371 580 112858 3622 900 83990 3066 3065 10000 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 111 11069 112 59345 3708 114 3709 2793 2792 3710 2791 2790 2782 2788 2787 2786 2641 2785 2784 5573 2783 5575 10681 51764 5576 3790 2778 5567 5568 26251 94235 10411 8826 5906 3745 55970 3747 5566 2740 9495 5577 54331 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 54623 8078 7415 255626 80349 7347 92305 3018 6596 3017 7874 9781 6233 56852 7321 51322 5591 5195 11065 5192 5193 7324 5194 3105 5828 7323 51255 9646 257218 55829 9810 220441 55284 7316 5111 27338 23168 8341 8342 8970 8347 7320 8348 8345 8239 90268 10670 8340 7322 997 7317 7319 3093 7332 7334 8915 7336 92912 56254 10477 118424 7327 7326 79139 7328 85236 29089 54926 7311 7314 65264 79577 123169 55236 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 1387 3958 861 865 1437 5579 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis 11035 8772 197259 7186 841 8737 8717 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells 3913 10319 3910 3914 3915 2335 3918 3909 7448 284217 3911 3912 3908 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing 23165 9631 7175 51504 11260 348995 1653 79897 9883 51367 11102 57122 10775 54913 80746 79042 51493 10940 339487 55746 113179 79074 4234 10799 8270 10557 134637 283989 283742 79691 81605 10556 116461 54974 10248 55644 55621 51637 51002 23279 84267 79023 81890 84520 152992 91801 10762 57604 51605 54517 6396 93587 115708 55006 90353 55687 63892 129401 84705 221078 54482 25821 64172 348180 79693 23536 4927 1787 24140 60487 54802 54901 54888 54920 10785 83480 5901 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 10898 79902 3028 51095 54931 9692 60528 8021 29894 1478 2058 112858 10978 55253 55039 57570 9836 127253 129450 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly 5567 19 5568 5566 335 29801 2 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency 5009 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 3815 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis 223 6470 8424 55217 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects 4860 IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response 6201 6203 6202 3437 3434 3433 6210 51065 6205 6204 6207 6206 6209 6208 6223 6222 6188 6224 6187 8454 6189 24138 6233 6218 6217 8662 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 10480 1964 6191 6193 6192 6194 6230 6232 6231 6234 6235 6227 6229 6228 3921 6500 2197 140032 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 2261 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 5294 5295 5296 10818 5290 5291 3667 5293 3643 5156 5305 1950 2064 1956 2251 79837 7409 3082 4233 2549 23533 374 2248 2255 2252 27006 4915 8396 627 8394 8395 7039 8503 5518 3654 5594 5595 3815 4916 2254 8074 2249 4908 2246 8823 8817 26281 146850 391 2099 23396 2534 3630 5155 118788 51135 2323 4615 930 5159 6801 940 941 2322 942 2264 207 50852 90865 8870 9965 5519 152831 9173 9846 5525 5515 5526 5516 5527 5528 255324 5529 5781 9542 3084 6714 2069 5880 685 2100 10718 1839 5879 7189 145957 2247 8660 3932 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes 27113 5366 8738 8794 8795 637 7159 8793 8797 332 1121 147923 8626 355 3486 79370 7161 63970 581 64065 1387 51499 9540 7157 23368 55240 27166 55367 835 839 58484 472 94241 665 843 834 10650 604 317 124446 84883 5875 5876 10397 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism 113675 10993 10247 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism 1462 3074 3073 63827 633 221914 9672 1463 4969 10675 26229 2239 375790 2719 176 9469 3339 113189 6487 4958 11081 2683 126792 1634 4166 2262 2331 1836 5549 6383 10082 6385 11285 9060 6382 2132 2131 2817 4060 22856 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME 6580 6579 9429 9376 213 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters 246213 340024 26154 6505 54716 6507 9056 23165 153201 1244 9631 7175 8647 1811 11254 10058 11136 6519 10060 7415 19 215 91319 6233 10599 348995 9883 55630 57122 23443 7316 55746 55343 10999 6005 9990 7355 23279 368 79023 21 9197 11160 8671 10762 3767 55315 6396 5172 6520 129401 6513 4927 9861 5682 2646 6514 5683 2645 5684 5685 5686 79139 5717 5718 5719 7311 7314 11047 5903 10213 5713 9688 5714 23225 7979 9152 5690 5691 55706 5692 23636 5693 9972 5694 6833 11097 5695 81031 23511 8086 5706 53371 9187 5707 8480 79902 5708 5709 6528 10479 285195 10568 5687 6569 142680 5688 5689 5700 5701 5702 6048 5704 91445 5705 10956 6521 6531 51009 6530 60482 6524 6523 30061 64241 64240 6566 6400 6557 6559 8021 6575 5826 6578 1836 5244 283652 27248 55788 116085 6584 682 10613 56606 26503 1356 123041 4891 9843 3098 5002 10559 28234 335 551 552 1080 553 554 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ 1675 1 81 197 7018 7273 5582 7422 7040 5216 5579 5004 5005 1950 1191 351 808 948 6810 6814 3082 6813 5660 5054 5265 213 5196 12 135228 5874 7277 7057 226 7450 7043 27154 7042 5473 2316 10487 5155 2 5267 5478 350 94121 3309 5578 8407 51097 5175 23052 2153 9749 54495 813 7114 3671 710 2266 66005 7414 22915 7123 3690 29106 83706 10184 2243 51571 2162 3699 54863 7044 10490 29789 51368 5552 7076 22927 2157 3920 2277 10916 7078 7873 5627 1521 5099 6414 308 2244 3700 5341 3827 3959 5340 54676 1893 259215 78991 5345 2621 9948 3273 6694 7424 7094 7423 334 2335 5919 55664 374354 10447 10257 87 51706 3479 928 139322 967 3481 6403 5768 3674 88 6647 1072 335 6678 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding 4968 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling 23421 10454 11108 9138 27237 6655 11214 1894 10451 7185 55512 8408 7410 50649 257397 50650 9826 6233 9828 7321 7409 22899 4790 10399 6453 8997 7323 8874 5924 7124 5970 10672 7316 10133 8772 7186 8795 8743 7531 8793 8797 4168 355 356 841 8737 8717 7322 8767 9530 7204 4792 9099 7332 7074 57449 9641 10273 27005 4804 835 220213 7311 9500 330 7314 331 26574 10616 142678 3654 56957 29 7132 7375 55072 81858 843 1540 64857 9825 7128 329 6654 23263 221472 9639 572 10018 5664 5663 9181 27018 23365 128272 396 55851 3551 6868 83464 29110 121512 9261 1147 8517 4615 5584 5599 23370 25791 8878 8837 23229 23118 23385 4803 51107 26230 10276 55701 100271715 54848 8841 389337 445328 9459 84904 26084 836 84888 25999 90268 8439 56928 6885 55160 2245 57580 5879 7189 387 3066 3065 6610 89846 8887 4099 57142 4974 7984 84894 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication 84515 28227 5518 5925 1869 23649 5422 7027 983 5519 5557 5558 5000 5515 5001 7029 23595 5516 23594 4998 4999 891 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression 400569 9971 6907 9968 9969 8648 10891 2274 96764 9967 55090 123 23054 1543 23097 19 23179 2101 219541 8202 50486 80306 948 1581 1579 34 84246 3158 3157 6667 27242 10498 1024 1387 112950 116519 9443 405 406 9442 211 9440 85441 57491 80205 9439 6822 6604 9575 9572 2168 6837 4800 4801 4802 2033 6257 7376 51003 6256 23389 5465 4199 8800 10499 6095 51129 9477 29841 5468 3992 90390 9412 10025 10062 892 79718 26230 183 27063 54600 57761 55588 2180 9441 5244 8841 51586 4520 10001 196 4862 81857 9915 1374 11010 84498 54797 1376 29079 2222 2874 7296 5469 133522 9282 6721 4899 376497 9862 335 9612 336 9611 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors 2867 2865 338557 2853 2864 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 7516 7156 5892 5889 4683 79728 580 641 10524 7486 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 10635 5890 9156 675 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle 5295 9528 5296 5783 10818 224 57498 9928 11180 1362 22852 94240 57579 394 1832 57449 222584 10963 55704 22800 857 55789 8502 11075 91544 2886 81839 27316 9231 9352 57216 56667 5361 23592 667 1969 9462 2319 27289 10817 7037 2909 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome 7039 5295 1950 2549 374 6714 2069 1956 5290 5829 685 1445 55824 1839 255324 5781 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication 4836 55666 811 5034 7341 23478 100128731 1982 6238 7329 9789 9775 64225 3312 7415 54431 7514 3309 6185 1981 6184 3069 6233 4666 28972 3837 26986 746 54464 3304 1603 10313 7316 54344 7431 8974 51726 402569 283208 1974 1973 8672 1977 9532 5033 317649 10294 10525 3836 90701 10527 2923 5593 84061 25777 689 7991 2194 7311 7314 81631 60559 22937 3839 201595 8813 3840 3703 3841 8818 5611 335 3838 10965 58505 7353 1650 4904 821 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 7316 27338 7320 8239 90268 7322 997 7317 8078 7319 3093 7332 92912 10477 7327 7326 7328 7347 29089 7311 54926 7314 65264 7874 6233 7321 11065 7324 55284 55236 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling 3718 3082 8835 6774 5295 5296 3667 85480 8968 5896 5897 3574 64109 3575 6777 6776 8503 54014 653604 8651 3716 8660 6597 1154 3561 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants 2322 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 1950 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis 7299 1638 4948 51151 7306 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation 926 1175 160 161 163 51606 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint 983 9133 7465 890 8900 9088 891 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling 5295 5296 5290 5291 5788 5335 8454 6233 7321 4790 1445 920 7535 5970 7316 5336 23291 7322 997 10892 8767 84433 5588 4792 7334 8915 7335 9861 5682 5683 5684 8945 5685 5686 7454 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 55824 5693 5694 5695 5170 5706 5707 5708 5709 5058 5687 5688 5689 5700 5701 5702 5063 5704 5705 917 3551 1147 3635 8517 50852 23118 51466 9402 3937 5728 6885 26191 7189 4690 5795 3123 5062 3122 3120 55740 3119 3118 3117 3115 3113 915 27040 916 9398 2533 3127 3126 3125 7408 3702 3932 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects 1029 VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis 5436 55746 5438 5439 23279 79023 10762 23165 6396 129401 9631 7175 4927 5430 5431 5432 5440 5433 5441 8021 5903 9688 23225 5434 5435 5437 55706 23636 348995 9972 9883 11097 23511 57122 8086 2963 53371 2962 8480 79902 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate 9942 10327 51084 6652 51181 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 7316 5520 4331 1019 1032 1031 1029 894 898 896 1017 902 5925 9134 1027 1028 4067 3717 5753 595 1021 25 1874 28227 1163 5518 1030 7311 8454 7314 6500 1869 6233 1870 1026 7027 1871 5519 6502 5515 5933 7029 1022 5934 5516 1875 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases 5921 6774 898 3091 2908 595 1950 2064 1956 207 6233 9542 2909 2034 7316 9021 3084 1019 10657 27043 10656 1017 2069 10457 5829 1027 685 120892 9564 9844 116985 63916 1796 1398 10718 1793 55620 5753 1839 5879 6725 5770 6421 202559 387 867 145957 7311 7314 4893 3265 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 9100 7316 5111 6119 83932 10714 55666 6118 9768 124739 51426 5424 57804 54107 9246 5980 10459 5982 7415 51455 5429 5983 9636 7318 7706 11201 7311 25898 7314 6233 5981 56655 5984 5985 5425 5426 7353 5427 6117 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions 57369 56666 24145 84694 10052 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants 3815 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis 26330 5210 5211 5213 2023 10007 23165 132789 9631 7175 5207 5208 2027 2026 669 5209 83440 5223 5224 8021 5214 5230 5232 2597 5519 348995 9883 387712 5515 57122 5516 5528 7167 55746 23279 79023 10762 6396 129401 4927 2821 2646 2645 5567 5568 5518 80201 3099 3098 5903 9688 23225 3101 226 55706 229 23636 9972 11097 5566 23511 8086 230 283209 53371 8480 79902 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 908 113457 347733 10383 6950 10382 7203 7278 7280 22948 79861 81027 7846 10693 10376 10574 10694 10576 10575 80086 7277 51807 10381 112714 84790 84617 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures 3914 3918 1299 1298 1508 649 1514 80781 1287 1515 1520 50509 256076 9313 7093 7092 5339 7837 3691 1302 1301 1306 1300 4015 4016 4017 1286 1285 1284 1282 1281 1280 255631 4322 977 1297 3655 5118 3909 84171 1278 131873 1277 1296 1295 1294 1293 4314 1292 4316 1291 1290 4318 1289 85301 84695 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 7316 3665 10133 9641 7311 3661 7314 148022 6233 10010 29110 7098 7187 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway 1515 3107 3134 3106 3133 3105 3135 1514 1520 4012 567 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis 7372 1723 790 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 340665 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels 3708 3709 5023 5024 7222 9127 5026 22953 6786 3710 80228 7225 84876 5027 5025 57113 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors 5030 5028 53829 5029 64805 10161 5031 5032 2840 27334 2846 9934 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste 2914 259296 259295 6337 6339 6338 2911 3710 2782 346562 2784 51764 6324 6330 6335 83756 6326 6328 50831 6327 50833 50832 3759 50834 50837 50836 50839 54429 259289 50838 259287 259286 54795 259285 5330 255022 119395 50840 6340 259293 80835 259292 133060 5726 259290 29850 80834 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 4851 54567 28514 3714 6868 102 182 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type 326625 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis 5476 4758 2720 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling 3082 3913 10319 3910 4233 5747 6714 3914 3915 3918 3909 3675 284217 3911 3688 3912 3673 3908 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand 5111 6119 10714 6118 2237 5424 57804 1763 26277 25913 65057 7013 7014 54386 5425 7486 6117 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling 5058 10627 28964 5062 5063 2051 2050 2049 2048 2047 2534 1949 8874 1948 6386 1947 5879 8440 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 6772 9021 3570 6774 3717 3569 3716 7297 5781 3572 867 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency 5009 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 5046 2657 5045 130399 91 92 10589 93 8928 4087 4088 9350 4089 4838 7044 5594 10637 5595 55997 2309 6998 199699 6997 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 8968 3013 8338 1789 1788 1786 255626 29128 3021 85236 8349 3018 3017 54145 3014 653604 8331 8337 8334 8335 474382 29947 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism 2317 5300 3434 1982 23165 9246 23586 25820 9631 51191 7175 4599 9775 9636 7318 7706 5335 11274 8021 1981 6233 9470 3837 7324 348995 9883 57122 4600 7316 55746 5610 23279 402569 79023 1974 1973 10762 8672 1977 6396 317649 129401 3836 7334 4927 6772 4734 8678 3661 7311 7314 5903 5495 9688 23225 3839 5595 55706 3840 3841 23636 9972 11097 23511 3716 8086 53371 3838 8480 79902 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions 84560 4520 4493 4494 4495 4496 4490 4489 4499 4501 4502 1465 4504 6620 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer 5728 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) 2767 59345 2769 409 2793 2792 2791 2790 2782 2788 408 2787 2786 2776 2785 2784 2783 10681 51764 2151 2149 2147 9630 94235 5594 5595 9002 55970 2768 54331 10672 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines 6303 196743 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling 3146 6285 6288 3958 6283 829 177 351 5589 5594 5595 830 1650 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 11081 4969 5549 2683 176 4060 2331 4958 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling 3718 50615 5777 6774 5295 5296 2185 5290 3567 5291 6850 1437 6655 5293 3601 3600 3563 59067 3560 3717 2885 3568 6777 3635 6776 3636 6772 6775 8503 6464 1439 1438 84868 9846 6654 3716 3562 3561 3578 3581 3559 3558 3932 3965 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) 6566 682 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane 23428 92745 6533 6510 206358 84889 6509 55089 117247 340024 10991 54716 120103 9056 9057 8501 153201 6541 6520 81539 123096 23657 55117 56301 11254 6539 11136 6519 124935 54407 8140 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 26277 25913 65057 7013 3013 8338 7014 54386 255626 85236 8349 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 4913 4968 8341 8342 8970 8347 8370 8348 128312 8345 8930 23583 94239 8340 252969 55766 26277 25913 65057 7013 3013 8338 7014 54386 6996 255626 79661 55247 85236 8349 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway 4248 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t 5236 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) 551 554 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters 116085 9356 9376 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 23421 9138 5664 5663 9181 27237 23365 27018 6655 128272 11214 55851 83464 121512 1894 10451 5599 23370 25791 8878 7410 23229 50649 50650 9826 6233 9828 7409 4803 22899 23385 51107 26230 6453 8997 8874 10276 55701 100271715 54848 5924 389337 445328 9459 10672 7316 84904 26084 836 7531 4168 55160 2245 57580 7204 5879 7189 57449 7074 4804 835 7311 9500 7314 26574 29 64857 89846 6654 23263 221472 9639 572 10018 7984 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 4791 4793 148022 28512 1660 8737 4790 28511 11035 3551 4792 81030 7098 1147 8517 5970 4615 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC 79887 255189 50640 254531 79888 50487 151056 30814 8398 8399 5320 5321 5322 255043 283748 10162 5319 123745 100137049 26279 54947 81579 129642 8605 22925 11145 64600 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p 440138 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly 5520 25909 7341 347733 7278 27243 79861 23165 81027 128866 7329 9631 79643 1104 51652 3842 3837 8815 348995 9883 5515 57122 7443 221496 29082 55746 113457 10383 10382 27183 91782 23279 2010 25978 7280 79023 92421 6396 7846 129401 10376 891 80086 3930 260334 5905 6683 5518 9798 7277 200014 5901 9133 347688 51807 9688 10381 22933 983 4001 112714 23592 55706 23636 23141 84790 23511 53371 79902 84617 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) 3373 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family 5336 93978 2207 143662 118430 6850 4582 4067 2534 4583 4584 4585 338339 4586 200958 727897 10071 94025 170482 140453 10462 4588 4589 283463 56667 394263 50856 26253 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 2247 2263 2251 2248 2255 2252 27006 2254 8074 2249 2246 8823 8817 26281 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease 5295 4893 2549 5335 6654 10818 5290 2264 3265 GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV 2997 2992 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 2911 6857 8825 2915 8573 143425 2906 2905 2902 341359 23136 320 2036 28988 64130 85358 9546 22839 26037 22871 9066 57502 57669 58512 127833 10611 91683 321 57596 26045 2037 6804 2035 57555 2904 9229 2903 9369 54413 9454 9455 347731 347730 9379 6812 9456 22829 22941 80059 50944 55327 1742 9378 81858 1741 1740 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 6575 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation 8547 10584 2219 78989 4153 5648 2220 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 7316 1508 1495 7410 9855 1514 50649 6714 7311 1499 7314 6233 9844 998 999 1500 79872 1793 1009 1520 5879 3728 7074 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 5293 4067 5294 5295 3717 23533 2549 2057 2056 5290 8660 5291 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis 147179 2268 917 644150 3055 6850 10006 26999 2534 2214 10458 10451 7525 10787 25 7410 4627 10109 10152 7409 23191 71 4650 4651 4644 695 4620 51517 4641 10552 10163 3071 5747 10093 9844 63916 10092 4067 1398 10095 8976 10094 1793 60 10097 5879 10096 10810 4690 7454 7456 55845 998 5594 5595 8936 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function 580 672 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer 7040 7048 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane 196527 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification 5929 4148 10445 23314 3190 5373 79868 4061 29929 4758 126119 4759 92552 9929 200845 80349 10945 57599 2109 9382 3416 80341 338328 114803 10617 23172 57559 116519 9861 5682 5683 5684 7039 5685 5686 5717 5718 5719 114907 11047 10213 5713 5714 7057 7979 410 5690 412 5691 5692 414 5693 5694 83746 415 5695 8703 416 5706 8704 5707 8702 5708 5709 7369 79694 5687 432 5688 433 5689 5700 5701 5702 8720 5704 5705 3312 51246 54757 8404 3491 7184 3488 3487 64856 10117 8021 1114 258 79823 7857 92305 5954 6596 56955 3270 9781 56852 285362 265 51322 401138 5591 51280 5195 56975 5192 5193 3956 5194 5828 4924 51255 8614 174 257218 54972 55829 3698 9810 220441 84141 9210 11098 54587 7416 9978 7703 2218 3098 10329 115827 10559 64284 30815 9486 57799 79147 5865 11041 376267 9215 84932 113829 8934 55624 6132 51715 729920 57403 1605 120071 401409 10966 8452 55647 25837 115273 142684 84078 83871 57111 8073 718 23165 79090 9631 7175 6157 6881 51762 23682 10890 9230 27095 4287 9363 81876 7323 348995 9883 338382 57122 201475 51399 1122 55746 6921 7109 6399 5861 11021 6923 51560 23279 5872 5873 79023 11031 4086 126003 4087 58485 10762 4088 4089 51693 6396 1737 116442 142 129401 122553 23011 1743 10981 64750 10825 4092 4927 7518 22931 5905 83696 5874 54734 83452 51616 5903 9688 23225 128637 55706 23636 9972 11097 23511 8086 53371 8480 79902 1462 411 2720 4286 59348 64135 3972 23586 2653 63967 8517 7706 2155 2153 2147 2266 2243 3053 8312 324 2159 2158 2157 8858 5624 5627 139285 462 3827 51156 5610 10210 145173 57188 2591 143662 5728 10417 118430 124872 5329 10418 2590 170689 171019 54437 9037 4582 2230 5199 4583 4584 7058 4585 4586 2625 200958 157869 29954 727897 652 29071 140766 80070 10585 9508 9509 10071 80124 94025 10318 79931 339366 161725 221981 55593 140453 78990 79875 81794 55432 79589 4588 55901 55611 4589 54764 81792 283463 9719 56913 394263 11173 11174 80731 54507 92949 170691 5611 4609 3091 79728 7040 7022 7021 7321 11065 7324 154 5970 27338 1029 3569 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 8869 6480 10427 256435 27090 9868 9641 288 11282 8678 444 6383 79697 89978 1819 83475 64122 1984 58505 55854 51611 4733 821 65094 91433 23463 79672 79831 92715 51389 114548 285381 120526 100137047 2589 55239 56648 100128731 1725 1802 1801 10610 29906 89122 10392 9097 11274 966 6185 8460 6187 1604 8459 6184 9334 9331 3105 11253 746 1603 7841 8775 5179 10618 6194 51128 84282 5423 6885 408 79369 2719 5878 2804 7187 7189 84061 55741 11320 22901 1522 7991 4245 4124 10802 9189 201595 10484 197370 493861 3703 9994 3090 115426 7690 79677 56160 54780 668 1154 10521 1655 6670 6672 1650 205564 147111 4247 4249 51602 10454 286053 8835 25950 23137 11315 4152 59343 6294 165918 409 64127 7153 7155 25834 7158 5893 7150 5589 9761 57719 64772 55768 51035 7415 64326 326624 4791 1000 23193 2530 7428 351 808 6502 9101 154881 374 113457 7320 4780 6478 1938 7280 283807 26272 51088 9616 1915 7317 7319 3093 26234 7332 6468 7336 10376 150726 118424 55336 7327 7326 26190 7328 26270 29089 54926 65264 93611 10381 9545 127247 401036 79791 55294 112714 51665 84790 51666 63891 142686 84617 142685 55236 51676 10238 142689 10517 8453 2519 347733 84261 80204 829 57542 7278 26224 23014 81027 54461 5071 25793 830 832 11275 64410 222235 54850 5870 140456 6400 140458 2683 140459 90135 146330 140460 140461 140462 401258 54620 10959 115290 7704 55958 8139 10402 390594 55284 84961 8924 122769 53916 2034 9021 53917 1315 55175 27252 51130 9903 2215 92369 126433 26259 201456 80028 144699 899 84861 92912 9146 10477 387 26268 7879 90293 10055 5768 10054 84727 92591 8875 26263 8876 26267 53339 285231 89890 9820 26235 26118 79176 26232 84085 4008 9817 51725 9039 26249 8065 140739 9040 5721 5696 5720 79754 5698 84541 5699 9554 80176 23194 136371 10324 197 993 2801 2890 4905 11338 9986 377630 11019 387787 27247 51601 349667 6117 7425 94005 5067 8733 146183 4194 116372 7186 2822 84720 54872 53942 1121 128869 152330 284098 353091 4193 51604 8737 4062 5277 137797 7322 6712 5279 997 4869 390243 93183 8581 9656 84628 4792 10942 55650 9099 171169 80235 8915 51299 249 7486 1075 7007 54965 93661 84992 10026 4978 360226 147719 5283 55860 9487 9488 135228 23627 161357 130576 8434 1043 1087 51164 7046 58530 7048 146760 1026 251 84516 5281 22854 80740 10671 503542 646627 51227 10232 419 349633 8000 8074 4241 4045 7512 5875 80328 5876 7070 83639 23556 7417 9212 7419 257194 266727 27076 420 9804 5034 1368 80055 338 1048 54742 284348 991 6975 890 50863 8900 3486 123904 154064 2813 81849 1616 641 3630 114785 55252 55777 8878 84749 3607 8314 7345 7347 221937 123228 171023 22915 55568 7874 8975 79812 81847 11227 1643 23252 11226 374378 5987 8658 51809 9245 80351 168391 63917 51146 51301 672 50614 148789 23275 8693 129080 140838 442117 374907 84620 55907 64409 146664 55808 5111 6489 84752 10020 140687 54187 84750 80896 84197 7903 114805 129807 2650 28996 192134 332 117248 146712 26290 170384 57452 10670 79623 2350 84892 10164 5371 580 5862 3622 286 5867 5868 260334 10196 347688 57134 4121 10905 93624 317772 85235 23326 4597 1081 23210 29880 25879 256281 84864 221613 8295 92815 8969 8607 440689 207063 84920 144245 6314 197258 7264 8790 29926 29925 2762 5372 57171 282969 221656 5476 22796 55343 79594 347517 84342 91949 25839 683 27314 51272 378 83548 57511 3490 9527 9609 10466 8542 55738 10678 213 3895 10970 8729 7466 56667 11015 8766 7353 55666 4052 11093 10130 7341 7376 7068 5241 6256 7421 5465 10113 8554 64344 10652 2099 3998 7181 6095 367 4929 4738 6612 2908 51377 51588 9759 5468 7329 6613 4306 5914 10401 11167 2516 51552 7157 91851 347527 10072 9570 10272 26043 84002 6811 9958 57104 6709 29086 51720 84142 9577 79184 6711 248 90268 153642 55143 26503 9126 8204 10735 10274 8243 5885 10254 8451 8533 340075 8450 64708 125476 51138 10987 1080 10980 93973 29844 9100 54891 79913 51143 50813 54617 10537 55208 10920 28952 1642 283899 23142 26094 83444 5886 54939 4798 9655 5887 23038 140825 10489 23369 7508 54951 23363 54165 9306 149951 1161 80344 255738 55827 23113 55832 84259 26958 56929 79016 51122 54876 50717 83987 150684 51014 8816 339122 90864 170622 23423 10116 372 29099 6790 23032 2107 79269 8454 51397 381 55884 8655 55527 23412 6233 56995 1781 9276 28991 27430 80067 123879 11316 8883 122416 1778 51514 22818 3183 1314 54732 1453 51226 22820 140735 7316 9738 11014 151194 22944 10383 79091 10382 79642 399818 254013 221143 79644 196483 23291 79609 1069 7846 10540 4218 8945 143471 389362 56984 7311 51371 7314 6500 80227 5710 10197 122706 5711 1294 983 8624 5715 5716 84262 9491 23198 10121 25862 100287513 11258 100287238 100287478 401447 9736 645836 728386 51651 100287178 29761 5864 57646 84101 100287327 9695 100287205 100287441 6048 91445 645402 3915 80267 100288520 8724 10206 56886 392188 10956 219333 100287144 267 10868 84447 10869 7844 23770 10299 55757 91833 11236 84196 51009 9960 8078 728419 100287404 100287364 3912 55031 9510 23358 83844 84364 57695 84132 10600 51209 9507 23256 5045 813 29106 25870 1471 90865 7076 4240 9318 170690 170692 6694 8239 334 2335 1487 5869 6696 55288 85365 56999 10331 56254 11096 79947 11095 8027 102 57591 79087 26286 10195 9367 335 336 8648 10891 5931 199857 54623 375056 348 7018 4253 11070 1780 1107 79053 2873 1783 29843 721 25809 23287 254173 25941 3619 374969 60509 79739 54839 158135 284076 22846 9654 375 8331 164395 377 8337 123624 8334 26140 8335 23170 23093 83887 79841 10342 91978 84276 8535 150465 79805 340351 84871 54344 51564 6304 8341 23168 8342 8347 8348 6045 8345 648 8340 7528 6015 1912 1387 1911 9526 60 8338 80012 57332 5265 8473 2923 8774 116150 84733 23243 22870 2348 64841 10175 55577 23468 10972 2673 5537 6675 9117 5973 11196 64689 51005 79139 5238 55291 85236 254263 9945 25956 8349 27005 55014 10155 81562 330 1639 63908 8615 149111 56052 9919 56957 90411 7375 10282 26984 79748 1540 89866 10960 7128 329 64426 22872 79577 123169 6708 79796 8313 86 811 6710 2033 8370 22845 10499 4351 1435 64377 9112 338596 4221 51046 3013 4248 4122 8128 1629 2517 6996 255626 79155 57731 3018 91869 3017 10474 287 51332 9646 93010 4706 2525 8970 2621 8850 128312 25942 2200 1798 2677 3054 1356 1789 1788 1786 3913 3371 3066 3065 440138 1758 4303 8813 2648 8818 11091 3484 9612 632 23512 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation 5928 23774 2033 27154 5931 5300 9219 5371 1107 208 84289 3622 5608 1108 7862 8396 7157 5305 54815 7994 29117 3066 64769 3065 207 79837 53615 10000 90809 57459 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway 7099 842 929 8772 7186 8795 836 8743 8797 353376 23643 148022 355 356 841 8737 8717 219699 1630 90249 9500 1613 1612 23604 26060 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 4067 1399 3717 4893 2057 6654 6464 2056 8660 3265 2889 7409 PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair 7295 4482 5110 253827 51734 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 2694 81693 8029 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency 38 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 5245 815 816 6714 817 22808 818 369 5500 4296 3717 5518 4140 8036 7529 673 808 5519 4893 5501 5604 5525 5605 8315 5515 5526 5516 5527 3265 5894 5528 5529 8844 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors 948 5052 3146 6288 338 284297 922 335 6280 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors 23166 338 55576 6678 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 126123 113177 928 284359 49 100129669 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 5687 5688 5689 5700 5701 6048 5702 91445 5704 5705 26154 10956 51009 1244 8647 10058 10060 7415 64241 19 64240 6400 215 91319 5826 6233 5244 27248 7316 55788 368 21 10613 11160 3767 9861 5682 5683 5684 5685 5686 79139 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 6833 5694 5695 335 5706 5707 1080 5708 5709 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) 7099 929 3146 23643 2266 6280 7097 2243 7096 948 6279 114609 6271 695 10333 51135 2244 4615 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 10454 64127 59307 11213 6279 6271 51231 1849 1848 1846 1845 4791 257397 8454 6280 7097 6233 7096 351 4790 948 10333 695 5970 7316 7099 929 7186 23643 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 2266 5602 4793 5606 28512 57161 3725 57162 2243 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 2244 6885 114609 7189 51295 8651 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 9021 1515 1514 122809 1513 861 5275 865 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 2033 60436 3726 23327 4221 1874 5045 892 5494 25937 6233 8812 7321 22938 7027 7323 5933 7029 7316 6667 6498 6497 5054 8239 4087 4088 4089 1024 142 64750 4092 51592 1025 1030 7311 7314 3065 1278 54778 23439 5594 5595 7050 9612 9611 4904 904 4609 1875 905 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 6209 6168 6208 6223 6167 6222 155066 6169 6224 9114 23521 6160 6161 6233 6218 6217 6175 6176 8649 6171 6170 6173 523 525 526 527 528 529 10641 10542 55364 1051 6181 127124 51382 1054 6230 6232 389541 6231 533 6234 28956 534 6235 57521 23334 6227 6009 6229 6396 6228 440275 652968 245972 79726 245973 54468 84219 55004 9550 7311 96459 154743 9681 8131 27244 2475 1386 8992 144577 90423 58528 10312 201163 468 9296 729438 10985 1649 55846 23677 81929 57600 11224 25873 6188 140801 6187 6189 11133 64223 440 57761 467 64121 9349 6191 6193 83667 6192 6194 10670 153129 1965 8894 10325 1968 3921 51606 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling 10454 64127 3551 3605 112744 9261 6197 6196 1147 6195 4205 8517 4208 10392 84818 79155 55540 51231 2002 1849 5599 1848 9252 1846 1326 1845 5609 466 6416 5601 257397 7867 8454 5602 5606 3725 6233 23118 4790 5519 1432 64806 5515 5516 5600 5528 5598 7316 27189 23291 6885 132014 8767 5608 7334 7335 7189 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 23765 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination 9100 29844 54891 79913 3091 54617 10445 283899 83444 5886 4798 5887 993 126119 92552 9929 7040 9986 377630 23032 57599 6233 7321 27430 3416 154 7316 9738 4194 7186 4193 8737 114803 10617 23172 57559 8767 57506 4792 9099 9861 5682 5683 5684 5685 5686 9868 5717 8678 5718 5719 7311 7314 11047 10213 5713 7046 5714 7048 7979 983 5690 5691 5692 5693 5694 5695 25862 5706 100287513 100287238 5707 100287478 5708 401447 9736 5709 645836 728386 7417 51651 5687 7419 100287178 5688 29761 5689 57646 9804 5700 84101 5701 100287327 114548 100287205 5702 100287441 5704 991 645402 5705 100288520 890 8724 392188 8900 219333 100287144 10868 10869 23770 91833 84196 9960 8078 728419 100287404 100287364 55031 23358 83844 57695 84132 89122 10600 10392 9097 114785 55252 55777 84749 3607 8314 11274 7345 7347 221937 123228 171023 7874 8975 81847 1643 23252 90865 8658 80351 672 7416 8239 84282 6885 5423 408 580 55288 7187 7189 8027 93624 317772 10454 85235 409 64127 23326 6881 221613 7415 8295 92815 8969 8607 440689 4287 6314 8331 6502 8337 8334 8335 221656 9101 8341 8342 8347 79594 8348 8345 6478 4086 8340 7528 4087 4088 4089 60 8338 64750 4092 8473 85236 8349 27005 51616 330 56957 7375 1540 7128 329 64426 63891 7353 8313 86 2033 2099 367 4738 5071 64135 51377 23586 3013 63967 8517 255626 7157 79155 7706 3018 3017 8312 9958 10474 324 29086 51720 84142 9577 79184 8970 8850 128312 5728 3054 2625 9146 387 80124 10318 79931 161725 55593 78990 55432 79589 55611 10254 54764 4303 9817 2648 125476 1080 93973 4609 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 9212 5687 5688 5689 5700 5701 5702 991 5704 5925 5705 9232 6790 6233 7321 25906 11065 8697 7324 6502 10393 29945 29882 996 51343 51529 8881 64682 7316 27338 119504 246184 51434 51433 5347 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events 2767 3708 3709 5153 5136 2769 3710 2771 2770 346562 2776 5582 5580 2773 5578 2774 808 5330 10645 5331 84254 5332 5577 111 112 23236 156 113 114 5137 814 115 815 5613 816 817 818 5321 196883 5573 5575 5576 107 108 5567 10768 109 5568 9630 5594 5566 3838 26960 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 55802 5393 23016 51010 167227 51013 3842 7529 118460 22894 56915 7538 11340 54464 9261 23404 54512 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction 5058 10627 4636 10174 2977 493829 2983 7094 5829 2982 8912 93408 859 8913 8911 140465 7169 8654 7168 4629 29895 217 309 8291 10580 25802 3672 3693 5062 58498 7414 7170 7171 808 4637 4638 10398 302 800 103910 301 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling 6908 57678 5295 8648 5296 5290 2771 94239 4343 2770 192669 23112 27327 26523 208 27161 192670 57690 595 861 5430 865 5431 5432 200845 5433 1950 5590 1956 8202 54145 808 3320 2958 2957 8331 8337 8334 8335 2963 2962 5436 5438 8341 8342 374 5439 6667 8347 8348 8345 2793 2792 2791 8340 2790 7528 2788 2787 10498 2786 1387 2785 2784 5451 8338 2783 51764 10524 2494 2353 7039 4602 8503 85236 1025 8349 94235 5594 1386 5595 55970 5170 23028 7090 904 54331 596 59345 2033 5481 8370 5241 2099 3480 10499 2782 346562 10728 3013 3326 2773 10681 8877 2289 255626 1509 7514 5440 6801 2002 340481 5441 857 3021 4846 3018 3017 207 3725 3014 5434 5435 8312 5437 2309 1903 5536 127933 255324 474382 8970 5747 8850 6714 128312 2069 1027 685 2100 55625 55766 858 51523 9126 8968 2288 8204 4435 6387 6722 7764 10735 1839 2625 3727 3169 2354 9166 9687 23189 10274 7033 8243 7392 7391 5469 7031 5885 3276 23030 3065 4313 653604 4314 4316 10000 4318 4893 3265 3838 1655 4609 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) 2720 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 2247 5295 2549 5335 10818 5290 4893 6654 2254 8074 2249 3265 2246 10817 8823 5781 8817 26281 GSD II%REACTOME%R-HSA-5357609.5 GSD II 2548 2992 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism 3620 125061 8140 169355 120103 51166 23498 6520 8564 56267 883 130013 8942 6999 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 7514 8021 5901 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 3304 53371 8480 79902 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants 7450 5908 22866 6714 7094 409 2335 369 408 10256 3674 283455 4140 2266 7414 3690 5037 2243 54518 7529 673 8826 5906 5594 5595 1445 4893 5604 5605 3265 5894 2244 8844 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling 5599 8808 84639 11141 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling 9049 196 10728 9915 3326 57491 405 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination 51585 1479 29894 1478 1477 22916 79869 6628 4686 8106 6634 134353 8189 6636 51692 6635 25888 6637 10978 84967 10914 23283 81608 53981 10898 11051 7884 55339 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels 50636 23327 196527 65125 1187 57719 1186 1185 1184 1183 1182 1181 133308 1180 1179 150159 7439 51802 7220 7222 7442 22802 7224 219931 7223 7226 6233 9635 7225 59341 79054 55283 1193 808 26133 2281 54795 8989 55503 4308 162514 255231 57192 1188 80036 56302 51393 6717 57113 29850 10786 54822 7316 140803 285175 65266 65268 65267 285335 144453 11059 10110 63982 6263 6262 94015 6261 23678 28962 55515 40 41 266675 54831 9311 161003 259232 7311 7314 7809 444 284525 55107 10345 1831 6340 5894 80727 57578 53373 6337 6339 6338 55129 121601 203859 57101 6446 338440 2040 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions 9723 64218 971 10154 3672 7305 8482 54209 91584 5361 23129 9037 3688 57556 10507 5788 80031 5362 5365 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA 80312 200424 54790 6996 CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis 5409 7054 1621 1644 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) 5687 5688 5689 5700 5701 1728 5702 5704 5705 4947 51686 9861 4946 5682 5683 5684 5685 5686 4953 5717 5718 5719 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 51582 5709 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 396 4168 4804 4099 57142 387 4974 84894 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 5423 328 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle 8500 10815 6511 6854 6844 6853 6616 5864 10497 6857 8825 6506 8573 6505 6507 6582 6580 57030 6572 60482 320 6512 6540 6539 18 3312 140679 6538 7915 54407 6529 80331 64130 4128 2572 2571 1103 27163 10550 6804 9256 27165 55327 2744 6571 8541 8497 22999 8224 8499 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation 51082 5928 10849 10919 6908 4331 57504 30834 84172 8850 902 5931 2074 404672 2071 9219 2068 1107 9112 54700 221830 1108 7343 25885 5440 5441 54815 2966 9533 2965 3066 3065 5434 5435 5437 53615 64425 2968 2648 2967 9014 1022 9015 7270 79101 9013 57459 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion 54931 9692 60528 22868 51106 387338 3028 26995 51335 81554 55178 79922 130916 51001 84881 285367 29960 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide 759 3043 760 762 6005 3040 358 6521 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling 4803 7531 836 4804 835 27018 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants 2322 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 197342 9100 29844 83932 10714 7516 84464 9768 54891 79913 7517 124739 51426 63979 50813 23514 80198 54617 55732 57804 9716 902 10038 79008 10445 2067 79728 10920 1642 283899 83444 5886 4798 5887 54107 7507 7508 1161 221120 51008 57599 4292 472 6233 27339 144715 5810 51514 5932 5395 11073 55215 6117 7316 6119 6118 4913 1069 1111 9656 7334 10524 7486 9861 5982 5429 5983 5682 5683 5684 5685 5686 4255 84126 5717 11201 5718 5719 7311 4350 7314 11047 10213 5713 5714 7979 5690 5691 5984 5692 5985 5693 5694 5883 5695 5884 5706 116028 5707 5708 5709 7156 5687 5892 5688 5689 4683 5700 5701 5702 5704 5705 4436 890 8900 3364 26277 25913 65057 10721 7013 641 7014 54386 5980 10459 51455 2177 2176 8314 11200 84164 10111 10973 4361 7874 1643 56852 1763 5591 545 80010 121642 672 9318 9156 5111 4968 9978 8930 11284 23583 8505 83695 252969 54936 5423 328 580 51567 79840 55775 55183 27343 64421 27434 79068 54890 7468 23030 54778 3838 91603 9682 5424 165918 404672 7158 5893 94239 2547 378708 51035 22976 54962 151987 5531 5430 25 8914 5431 7415 5432 2873 5433 79661 6917 55247 8607 54145 56949 8331 8337 8334 8335 1022 5436 5438 8341 8342 8347 5439 7320 8348 8345 8467 8340 7528 8178 142 7520 60 8338 7336 7518 199990 2175 55120 2237 85236 64858 8349 2956 29089 2189 22909 9937 91442 3981 7398 2188 353497 2187 80233 201254 57697 2178 3978 8290 7353 55666 86 4331 7341 8370 8554 6047 6612 9246 51588 7329 3013 6613 10401 6996 51750 63967 9636 255626 7318 7157 10450 5440 5599 7706 5441 2966 25898 2965 3018 3017 3014 5434 5435 5437 51548 2968 2967 347442 5536 139425 29086 5890 9025 474382 2070 57461 8924 51720 322 84142 9577 5889 79184 2140 2139 8970 1017 128312 2074 2071 55766 84295 2068 57654 9031 83990 4437 8451 5981 8533 8450 2073 2138 2072 64708 56655 85015 5888 7515 9557 125476 10987 51138 5425 5426 348654 10980 10635 5427 93973 146956 675 3980 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 3791 2803 51411 2120 23189 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 10608 2567 2566 5295 5664 5663 5241 11033 5290 348 55879 2099 3925 55851 1447 6868 83464 6285 1950 1956 51741 6233 23118 23385 51107 10413 9542 7316 3084 6714 2069 11059 685 83737 10718 6387 1839 6776 145957 2670 4734 6464 7311 7314 1742 2562 2561 2560 4893 6654 2554 3265 9611 6678 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis 2572 2571 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism 2760 8705 4074 8706 112937 3074 3073 79411 411 2720 81849 2583 89944 2581 427 4758 29906 4759 339221 55512 9514 347527 25870 84002 285362 9334 9331 64781 56624 57704 55627 5476 2524 2523 5660 7357 79642 153642 7368 6483 2717 10825 6487 8869 53947 2629 22901 30815 57733 340075 6610 410 6609 412 414 415 416 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death 4976 11035 197259 1687 10211 3002 8655 6233 3320 1613 1612 23604 26060 7316 140735 7099 929 8772 1029 7186 8795 7532 7431 8743 7531 8797 353376 23643 148022 355 356 841 5339 8737 8717 5588 9861 5682 5683 5684 23368 5685 5686 5717 10059 51074 5718 5719 1499 7311 839 7314 11047 1830 10213 5713 5714 7979 5317 5690 5594 5691 5595 5692 5693 5694 5695 5706 5707 5708 22900 5709 57099 572 79792 9414 10018 596 840 5533 842 27113 5687 598 5688 578 5689 56616 5366 6774 5700 7159 637 5701 90427 5702 5704 5705 10971 7161 999 5580 219699 1630 90249 3146 7534 1829 207 57162 1991 7529 2810 837 838 6386 3552 3553 317 3606 836 2339 8626 83737 22985 581 10000 7082 5534 7533 55075 27243 208 128866 10015 660 79643 51652 834 29082 6304 91782 25978 92421 3009 3008 3007 3006 54205 3005 1677 1676 7332 3024 3148 3836 8473 6093 1832 115209 10273 9500 330 331 1828 2319 329 3660 3659 4836 79658 5071 63967 2620 8428 118 7157 51765 28988 5599 4137 2934 100506658 1869 7027 3837 708 324 6709 7029 11140 5747 5062 10134 4001 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 3032 3030 33 3033 1892 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins 1544 4048 246 1543 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling 5578 10603 5777 10019 4067 2534 9306 6654 3815 8651 7525 3932 867 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 840 842 56616 54205 836 317 331 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 5928 5687 5688 4331 5689 5700 898 5701 902 5702 5704 5925 5705 9134 890 8900 993 208 595 1874 4149 8454 1869 207 6233 7027 6502 7029 1022 5934 7316 91750 1019 286826 132660 55957 1017 1027 5753 9861 5682 5683 5684 5685 5686 1163 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 1026 7979 91768 5690 5691 10000 5692 5693 5694 5695 7465 5706 5707 5708 5709 4609 1875 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G 7316 5687 6921 5688 5689 5700 5701 6923 5702 5704 9978 5705 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 8065 5695 5706 5707 5708 5709 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors 5021 551 552 553 554 5020 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 1056 5407 5408 5406 8513 119548 1208 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 5034 6649 653361 538 343 25828 5052 2877 54205 1536 318 2876 2950 1535 10587 7001 475 9973 7296 7295 257202 9588 4688 847 10935 6647 4689 6648 50507 2880 2878 493869 2882 30001 79400 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex 6119 6118 29935 10926 55388 1017 8317 23649 5422 54107 5557 5558 84515 4172 4173 4174 4175 4176 8318 4171 56655 990 51053 5000 5001 23595 23594 81620 5426 4998 5427 4999 6117 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 10559 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 6772 6774 5295 5156 4893 5296 6654 5290 5291 3265 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes 100996717 100996763 388677 1991 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly 5567 19 5568 341 5034 346 338 4547 344 345 29801 348 51128 5566 335 336 337 2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA 51585 1479 29894 1478 1477 22916 79869 6628 4686 8106 6634 134353 8189 6636 51692 6635 25888 6637 10978 84967 10914 23283 81608 53981 10898 11051 7884 55339 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL 5321 3032 3030 6901 253558 8398 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 3163 3162 644 645 4363 10599 1244 28234 54658 2168 9429 2938 54657 213 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 83930 866 3294 1589 3293 51171 1588 6770 3292 51170 1586 79644 5443 1585 1584 1081 2232 51144 441282 2230 3972 147323 10948 6715 6716 112812 706 9256 134429 3284 3283 412 1583 3291 231 3290 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 7316 3730 2549 5295 10818 5290 2248 2255 27006 10253 8569 53834 867 2247 5518 5335 7311 7314 2251 23768 23769 6233 23767 673 5594 10755 5595 7049 4893 6654 5515 2254 8074 5516 2249 3265 2246 10817 5781 161742 8817 200734 26281 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 91603 10714 4331 51426 5424 9716 57804 902 2067 404672 1642 54107 7507 1161 5430 5431 10450 5432 5440 5433 5441 6917 2966 2965 7874 6233 5434 5435 27339 5437 56949 2968 2967 1022 57461 6117 7316 5111 6119 5436 6118 5438 5439 2074 9978 2071 2068 57654 5982 5983 7311 7314 8451 5981 8450 2073 2072 56655 5984 5985 5425 5426 5427 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants 238 80304 5777 6774 5295 3726 5296 10818 5290 5925 5291 3667 4343 597 50616 192669 6238 26523 27161 192670 57674 57690 2885 7175 9451 27436 3831 3002 8496 3799 7157 6801 5599 8878 5335 4627 5601 8454 7414 1213 3725 57448 6233 3092 5551 9648 833 10342 7535 7316 2305 1051 6194 9978 2335 1937 4193 7297 29851 3662 4869 5573 471 6776 1786 891 53335 6772 7311 3587 7170 1639 7314 7171 5903 5495 6500 4170 3065 1026 7291 4008 5594 51530 5595 3586 22872 10817 4478 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels 3768 59345 3773 2793 2792 2791 2790 2782 2788 2787 2786 2785 2784 2783 10681 51764 9568 3760 3761 2550 94235 3759 3772 55970 3762 3763 3765 54331 3766 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 29986 25800 57181 27173 29985 283375 7922 55630 23516 64116 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 21 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 4233 3094 1029 6932 1017 6934 1499 25942 3065 1026 5347 994 595 6909 891 83439 51176 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 9554 51143 375056 4253 11070 1780 2801 79090 2890 4905 26958 1783 51014 10945 23423 372 381 8655 27095 1781 9382 9276 81876 11316 375 377 1778 22818 1314 10342 54732 1453 51226 51399 22820 140735 7109 11014 22796 6399 5861 374 84342 91949 25839 378 51272 126003 83548 58485 57511 9527 6712 51693 6396 10466 10540 122553 9871 55738 5265 8774 9632 1075 93661 23243 22870 2348 10175 10427 10972 7039 5537 9117 55860 11196 64689 8729 288 83696 55291 254263 25956 55014 81562 1639 63908 51164 8615 149111 9919 84516 90411 11015 10282 1294 26984 10671 79748 128637 89866 10960 10121 22872 11258 6708 6710 829 10113 10652 3998 830 832 3630 84364 23256 2153 966 9570 57731 1604 6811 287 10959 51332 2157 6709 8775 1315 6711 51128 286 2804 1522 10802 26286 10484 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA 26147 5928 8341 8342 8970 8347 8370 8348 128312 5931 8345 2146 2145 94239 8340 340602 55766 8726 8968 3013 8338 1789 1788 1786 255626 3021 3720 85236 8349 3018 3017 54145 3014 653604 22823 121536 8331 8337 8334 5252 8335 100170841 474382 23512 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth 6710 1299 1298 5786 1463 2534 375790 8128 9252 57731 1287 51332 782 785 6709 775 776 7903 6711 5747 256076 783 9048 784 779 8912 6900 64096 4902 4684 2675 5621 6712 8913 5623 8911 2668 1286 1285 1284 1282 1297 131873 1293 5594 1292 5595 1291 2674 4893 6654 3265 6708 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site 811 821 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels 3764 3767 6833 10060 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 80824 3570 1849 1852 1848 1850 1846 3569 7297 983 11221 5594 5595 3717 5604 1844 5605 1843 1847 3716 5781 8682 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors 3640 10022 6019 59350 51289 122042 339403 117579 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex 4331 902 404672 54623 22916 4686 6749 5430 5431 5432 5440 5433 5441 80349 6917 2966 51497 11198 2965 8812 5434 5435 5437 2968 9646 2967 1022 2963 2962 5436 6921 5438 23168 6924 5439 4298 6923 85403 2071 6830 7469 4300 8178 2068 6829 27125 55840 6827 9150 1025 25920 51224 7936 55677 79577 123169 904 905 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis 11001 11000 55301 3293 401494 47 253017 22880 79966 51144 31 81616 60481 6785 79993 23205 201562 5538 51495 79071 197322 51703 109703458 6319 2194 9374 7923 9524 23305 83401 9200 2182 84869 2181 2180 64834 54898 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism 79178 80704 60386 27010 10560 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors 2893 2892 2890 2891 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends 7156 4683 8370 165918 890 7158 8900 3364 6047 51588 641 7329 6613 54962 151987 5531 63967 8914 255626 10111 4361 3018 3017 54145 472 6233 3014 1763 545 144715 51548 80010 5810 672 5932 11073 29086 9025 9156 51720 8924 6117 7316 6119 6118 84142 9577 79184 8341 8342 8970 8347 1017 8348 128312 8345 8340 83695 1111 580 9656 7334 10524 7486 7336 5982 5983 83990 84126 7468 85236 8349 7311 7314 5984 5985 5883 8290 5884 116028 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors 5739 5731 56413 5737 5732 5733 5734 57105 10800 11251 1241 165140 2840 6915 5729 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy 7316 7417 7419 10133 79065 54543 9804 7416 9927 7322 5071 29110 7332 7334 7335 8878 9868 65018 7311 7314 81631 6233 7323 9140 51001 10452 9474 55669 84557 100188893 401505 56993 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization 3791 7424 2277 7423 2324 7422 2321 5228 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion 2158 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 7039 1950 374 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency 162417 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 4919 1212 1175 160 4920 161 163 7855 2535 1213 1211 7474 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E 200894 56623 5147 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination 100 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function 24 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) 4802 1388 10954 811 6347 55033 10130 1649 9695 8720 10113 84447 22926 2081 11340 10106 8570 9451 23404 9709 54512 118 3309 7184 3576 5393 9797 23016 5073 116138 9114 51010 9570 167227 51013 58477 118460 2931 1663 22894 1200 440 56915 10897 5526 467 64061 37 1051 2137 2135 51726 1054 7094 56005 2134 51360 6734 6745 1965 8894 7709 55738 10525 1968 81501 153222 6818 90993 64764 148327 3068 2673 84699 10488 100137049 4189 7466 6464 9820 1639 11015 55062 27230 4000 3484 5611 22872 30827 468 4800 4801 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ 79644 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 5687 5688 5689 5700 5701 5702 409 5704 57154 5705 6233 3549 8405 8650 7316 50846 156 132884 2121 23288 2622 51684 6469 1452 84455 9978 374654 83737 408 6608 11127 64750 23432 2735 9861 5682 50937 64399 5683 91653 5684 5685 2619 5686 22873 25989 5717 2737 339745 5727 5718 2736 5719 7311 7314 11047 10213 5713 5714 7979 5690 5691 8452 5692 5693 5694 5695 79577 5706 5707 5708 5709 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 10020 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways 55746 5610 23279 2633 79023 402569 10762 23165 6396 8106 197259 129401 9631 7175 3836 4927 9636 8021 5903 9688 23225 3839 3837 55706 3840 23636 3841 348995 9972 9883 11097 23511 57122 8086 53371 3838 8480 10898 79902 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle 10250 11329 7431 908 7919 5930 79869 55023 87 124540 6434 5756 3326 8654 29766 6093 10574 56254 10576 23013 2873 9475 27316 23221 9352 9886 3320 8452 71 1627 3183 9318 51138 4646 11140 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) 6616 6804 112755 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 6531 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants 5156 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 54207 3776 50801 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 11253 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 5111 6119 10714 6118 5424 57804 10038 8505 54936 5423 328 54107 142 5982 5983 2237 5981 56655 3978 5984 5985 5425 5426 5427 6117 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant 2159 2158 2157 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation 983 84515 5000 5001 23595 23594 4998 4999 891 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 1135 1134 8973 55584 1143 89832 1142 1141 1138 1137 1136 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT 9402 10603 5777 6774 5295 5296 1215 5290 10750 1111 2241 10076 4067 2534 3717 9306 2242 5879 7525 2887 6777 6776 867 6772 5578 8503 2886 10019 7409 7006 4318 4893 9846 6654 3815 8651 3265 5781 3932 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome 164668 403314 200315 339 9582 10930 27350 29974 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor 88 815 816 4747 817 5923 818 1742 808 2906 2902 4893 1741 1740 3265 5924 2904 57554 1739 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription 30818 2908 5978 6722 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type 1462 1634 2262 63827 633 221914 9672 1463 10675 6383 10082 2239 6385 375790 11285 2719 6382 3339 2817 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling 3718 6774 6464 6655 3601 3600 3560 9846 6654 2885 3716 3561 6777 6776 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins 51602 286053 23137 11315 4152 8648 10891 6294 165918 7153 7155 23314 7158 3190 5893 7150 1107 23165 7508 9631 7175 7022 4791 6790 7021 3619 7428 348995 9883 57122 3183 8535 6117 5970 55746 51564 6304 1029 6045 23279 79023 648 4193 1069 6015 10762 4869 6396 1912 142 1387 1911 9656 129401 4792 80012 7486 4927 57332 84733 7518 23468 5905 9641 10155 5903 9688 23225 55706 23636 9972 83746 11097 23511 8086 53371 8480 79902 9212 2033 7341 7376 8370 7068 5241 6256 7421 5465 8554 2099 4286 7181 10499 6095 367 59348 4929 6612 2908 9112 51588 1616 9759 5468 641 7329 6613 4306 5914 10401 6996 2516 8517 7157 8021 5987 672 8924 5111 5610 10210 28996 332 25942 1487 5371 55143 9126 3622 7703 8204 10735 1789 1788 1786 10274 8243 5885 57591 3066 3065 9189 197370 493861 9994 3090 115426 7690 79677 56160 9612 54780 668 10521 1655 6670 6672 23512 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes 7316 8878 7311 4804 7314 6233 3654 4803 8767 3551 7189 5584 4615 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol 4809 51602 6128 6129 10171 6201 79050 6142 84916 6203 10813 6202 23160 6141 6144 27042 55127 54555 6143 54433 84128 6146 51202 6147 8602 92856 65083 11103 6139 1736 6138 9277 25879 6152 9790 51096 6155 6154 55651 6210 55813 5822 6157 6156 27292 6159 56902 6158 2091 51065 200916 115939 25926 6205 114049 6164 6204 27340 6166 9045 6207 27341 6165 6206 10436 6209 57647 6168 6208 55623 6223 55226 6167 6222 88745 55505 6169 6224 10199 9136 23521 6160 57050 22984 6161 51504 55272 6233 51077 6218 10607 6217 4691 11056 6175 9724 6176 84135 134430 6171 51118 10885 6170 6173 79897 11102 1454 54913 1453 10799 10557 6181 10556 6230 6232 6231 6234 6235 6227 6229 6228 7311 22803 10528 11340 23404 4839 54512 11224 5393 25873 55720 23016 8780 54881 6188 51010 26168 140801 6187 81875 6189 79159 51013 51388 90459 8568 55759 705 118460 79707 22894 57418 23246 23481 56915 26354 55131 81887 84946 55781 117246 83732 10969 9349 6191 6193 6192 27043 6194 10438 5394 10200 3921 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 9188 6137 23517 6136 51121 140032 4736 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u 54344 8813 8818 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling 4803 5335 4914 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression 4343 192669 23112 30818 27327 26523 2908 27161 5978 192670 57690 6722 266743 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) 23530 3420 38 92259 2271 3419 23410 3418 4191 8802 1738 81689 10131 8803 3421 1743 54949 8801 50 1431 135154 6389 57001 57128 4967 6391 6390 644096 6392 122961 2395 751071 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis 9514 53947 8705 2524 8706 2523 7357 30815 84002 81849 2583 9334 9331 64781 7368 6483 29906 6487 8869 FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants 7316 2322 7311 7314 2323 6233 867 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 126410 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation 9397 23576 114757 4836 340481 51070 857 115677 4846 10434 1785 207 808 3320 80777 6697 8976 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation 6286 7130 6282 3417 175 10043 9342 197 51806 83858 22918 51816 6278 84766 4057 6279 3608 51411 6037 5806 728358 4758 671 10855 5657 2588 4069 6947 6280 80331 7226 7097 8649 1992 6556 1669 8993 929 121260 6518 5660 353376 28956 3934 3689 820 5646 1075 6515 9861 5683 5686 55860 1823 1512 5717 5718 5719 55004 2171 10120 10213 5713 410 5317 5906 5594 5695 5707 5708 5709 79792 5689 3958 5701 5702 5211 3310 427 5580 634 3312 2799 5223 2444 1432 3304 719 317 5834 327 5836 1378 8621 7133 5236 9798 4893 56729 11240 1675 718 2547 2665 57554 10890 4125 4126 5476 1727 683 5873 11031 58485 9218 7520 6093 210 374403 1832 22931 10970 221 226 1828 230 2990 93100 3074 411 2720 10788 8566 8560 4831 5478 51552 28988 5175 383 8895 2934 1460 3685 272 161 4860 9588 6709 57126 11001 5023 79888 5269 5328 7276 5329 11010 5049 5199 4311 2821 5795 8694 2040 3101 2219 978 5611 51316 5337 64333 5724 57153 6616 5777 51143 2358 23200 23526 6793 10555 8904 10577 55832 79895 240 29099 8655 23412 4790 8826 3320 1778 203068 527 8987 3163 3071 10383 51382 79980 535 8773 10092 8778 10097 6402 51071 80184 27180 23250 2357 126014 976 4048 10396 10312 11026 5864 5663 2268 391 55276 3903 2212 3326 10288 51209 1509 1508 3146 966 6283 728 1604 1511 5315 178 1471 1991 23385 3107 3106 7077 53831 81619 6386 1520 823 3482 7305 1729 25852 51125 54509 81567 2512 960 5869 8673 2495 8907 2717 5878 64386 290 961 84061 10159 684 101 1522 140885 102 340061 4257 5645 138050 10326 4317 4318 158747 84658 1650 3684 2760 1 4973 1476 94103 567 2352 196527 6727 127829 9761 3240 79930 3615 1536 3614 1535 1084 353 23601 5788 89777 3728 6317 7415 5004 56888 5005 8514 326624 84443 5036 387921 222487 29108 26 948 23191 258010 26578 23197 5912 23071 84418 30 2896 374395 1116 5908 1143 387263 6836 83716 160364 1938 47 23218 5553 1915 5547 25840 56954 10533 64114 57826 5265 10694 9961 10576 25801 8635 10321 51646 12 9522 9535 10075 6036 9545 1654 55 25798 25797 23593 8288 9145 84514 3848 79169 2519 22875 54472 5473 201294 6993 80301 10875 10857 3043 114790 124583 2919 388698 2950 388697 338339 10487 4332 10493 2517 3579 4353 353189 10450 3577 11322 5870 23317 55754 2683 11333 80142 170482 11314 7414 55313 6590 5273 199675 5284 401258 23352 3837 10394 150372 100049587 3916 1794 3920 2992 51719 57020 1774 23114 53916 53917 1315 10549 8972 2207 1118 2204 932 2215 116844 4718 3687 3683 963 5879 965 945 967 968 4680 387 7879 5768 2548 8876 1088 847 8804 5787 5799 8836 23406 4282 566 4033 9725 10562 302 441864 1265 84329 54918 29952 154664 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 2767 23236 5330 2776 5331 9630 2769 2864 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 5687 5688 5689 5700 5701 9184 5702 991 5704 5705 890 8900 4085 701 6233 7321 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 7316 27338 119504 246184 51434 51433 4751 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 7979 983 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 10058 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 2247 5335 2254 8074 2249 2246 8823 8817 26281 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 3815 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly 57165 375519 57369 2702 2701 2700 127534 2709 2707 2703 219770 125111 10804 81025 84694 2706 2705 2697 10052 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants 2322 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN 23220 29110 81030 3661 147945 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 54492 7316 54567 57534 5664 1272 5663 3714 55851 83464 100996717 28514 4853 7311 182 102 7314 9148 142678 6233 23385 51107 100996763 388677 4192 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 116085 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea 55584 129446 25861 161497 124590 51168 11344 8573 64072 4647 53904 494513 3778 9750 3779 259236 65217 23136 339768 117532 117531 25794 283310 643226 340990 286262 375611 2036 3781 4354 10518 5357 53405 2934 7430 10083 57053 4627 64787 222662 83715 9132 389207 2059 5962 140469 6709 4641 6711 5756 4478 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression 51082 10849 6908 30834 2033 8370 94239 3013 221830 23451 255626 5440 10514 5441 3021 9533 3018 3017 54145 3014 5434 5435 5437 8331 8337 8334 9014 8335 9015 9013 474382 7913 8341 8342 84172 8970 8347 8850 8348 128312 8345 2074 8467 8340 55766 8968 60 8338 9031 25885 85236 8349 653604 64425 2648 9188 79101 2932 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 7516 7156 5892 5889 4683 79728 580 641 10524 7486 83990 10111 4361 472 7979 1763 80010 5888 672 5932 116028 10635 5890 9156 675 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy 51143 11315 30849 27243 1780 123 128866 7405 7415 1783 11345 8408 79643 51652 8655 472 6233 1781 3320 8649 1778 7323 29082 7316 140735 10133 10542 11337 10013 91782 389541 25978 28956 57521 7322 6009 92421 10533 10226 7332 7334 7335 5116 7248 9868 7249 8678 5289 55004 7311 7314 81631 8897 53632 2475 55062 3297 9140 51001 22863 58528 10452 9474 1068 84557 100188893 139341 401505 56993 7417 7419 79065 200894 54543 9804 9927 51422 5071 29110 5562 5564 3312 4077 5830 8878 84749 65018 1460 5571 64223 1459 1457 5563 5565 55669 64419 64121 2034 7416 8100 10670 153129 10325 115201 55054 89849 285973 56270 55626 9776 23710 84971 440738 9821 60673 11152 84938 83734 64422 23192 26100 1080 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA 6529 6540 6539 6538 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors 815 8825 816 4747 817 818 8573 2906 2905 2902 320 116443 2904 1739 2903 57554 116444 88 55327 1742 64130 57576 1741 1740 26960 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity 9212 6907 814 28996 815 816 817 818 25942 4343 192669 23112 27327 26523 27161 192670 57690 2874 3064 3930 2290 3066 3065 808 79718 5566 9612 9611 8841 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases 808 836 837 838 1992 3553 3606 79792 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) 6524 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 7316 5687 5688 5689 5700 5701 5702 991 5704 26271 5705 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 51343 5707 5708 5709 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants 238 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters 160728 8402 26503 1468 6576 159963 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System 7099 929 81622 23643 148022 6279 7100 114609 3551 4792 7098 6271 1147 7187 51135 8517 4615 81793 3146 4791 2147 710 2266 6280 3818 7097 2243 7096 4790 948 2161 695 10333 51284 2244 5970 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity 5687 5688 5689 650 5700 5701 10891 4488 5702 5704 57154 5705 2099 2908 865 579 2101 8454 6233 6502 7316 59269 9978 11059 9861 5682 5683 1749 6772 5684 5685 5686 10273 5717 133522 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 7291 5690 5691 5692 5693 5694 5695 5706 5707 2932 5708 5709 1750 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion 23421 51143 55732 401541 64105 378708 1780 79172 1783 83540 80152 8655 3619 64946 1781 1778 348995 57122 699 140735 55746 25936 9793 23332 6232 23279 79980 79023 54908 5347 22919 6396 5048 891 151246 9735 5905 5518 1062 9133 5903 983 220134 57082 54820 5501 6249 79902 9212 25909 9183 54821 9184 991 23122 4085 701 81930 84643 55920 3796 57405 7514 10403 80776 11243 23047 5519 113130 23244 5525 23063 5515 5526 5516 5527 11004 5528 5529 91687 57551 79682 11130 332 2491 55839 8379 55143 9126 10735 55166 10726 79019 10274 8243 1063 1060 151648 5885 1058 79003 55055 81565 147841 348235 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME 3251 10057 2030 7498 7410 55270 3177 9153 10257 7409 7172 2987 3615 3614 2939 2938 5879 10451 4830 8833 2944 4831 64078 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 6801 57599 81608 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase 23421 51143 64105 8655 6233 7321 1781 25906 11065 8697 7324 10393 1778 29945 29882 996 699 51529 8881 64682 7316 27338 140735 119504 246184 25936 9793 51434 51433 10383 10382 23332 6232 79980 54908 5347 22919 7846 5048 9861 5682 891 5683 151246 5684 9735 5685 5686 5717 5518 5718 7277 5719 9133 7311 7314 11047 10213 5713 5714 7979 983 220134 5690 57082 54820 5691 5692 5501 23141 5693 5694 5695 6249 5706 5707 5708 5709 9212 5687 5688 5689 5700 5701 54821 9184 5702 5704 23122 991 5705 26271 4085 701 55920 7514 3842 11243 11130 332 55839 8379 55166 79019 260334 6683 9798 200014 347688 79003 55055 22933 81565 147841 401541 378708 27243 1780 23165 79172 128866 9631 1783 83540 79643 80152 1104 51652 3619 64946 8815 348995 9883 57122 29082 55746 113457 27183 91782 23279 25978 7280 79023 92421 6396 129401 10376 80086 3930 5905 1062 5901 51807 5903 9688 10381 23592 112714 55706 23636 84790 23511 53371 79902 84617 5520 25909 7341 9183 347733 7278 79861 81027 81930 9232 7329 84643 3796 57405 10403 80776 3837 23047 5519 113130 9700 23244 5525 5515 23063 5526 5516 5527 7443 11004 5528 221496 5529 91687 57551 79682 2010 2491 55143 9126 10735 10726 10274 8243 1063 1060 151648 5885 1058 4001 348235 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) 6578 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA 1738 55526 1743 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress 4802 1051 6347 1649 1054 22926 11340 8570 23404 9709 54512 3576 5393 23016 5073 51010 167227 51013 118460 22894 440 56915 3484 468 4800 467 4801 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation 2893 88 815 816 4747 817 818 2891 1742 808 2906 2905 2902 1741 2892 1740 2890 2904 57554 1739 2903 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f 9526 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina 4001 839 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 551 552 553 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 3551 1147 8517 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling 5058 5567 3384 5568 9252 2033 5062 5063 5971 4790 30835 4067 2534 1387 4893 5566 5894 3265 3385 5970 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 9371 6517 6844 7533 23433 23216 10971 9847 57186 51422 9882 208 79058 57148 5564 51552 10890 7534 4627 5571 207 7529 808 2810 5563 5565 4644 6810 6814 4641 7532 7531 23265 5872 8773 60412 54536 11127 10640 4218 11336 5879 149371 5867 55763 55770 4012 5898 53632 8766 22920 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex 30849 79643 8678 5289 51652 91782 25978 81631 27243 92421 128866 7405 29082 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 6772 6774 5295 5156 4893 5296 6654 5290 5291 3265 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins 240 4048 246 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress 6119 6118 10926 55388 1017 8317 3364 993 1111 995 63967 5982 5983 84515 4172 4173 4174 84126 4175 4176 8318 4171 545 144715 5984 990 5810 5985 5000 5001 5883 5884 23595 23594 4998 4999 6117 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 7913 7341 2033 3329 348 2099 7528 1081 4869 1387 4435 10370 7329 4839 7422 163732 7039 5308 4605 2064 79047 7022 1956 7021 83741 51741 339488 7020 284252 10765 29028 1026 8089 3815 94115 4609 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation 5436 6908 4331 5438 5439 902 129685 6872 404672 6874 2071 6873 138474 2068 6881 6880 5430 6883 5431 6882 5432 5440 8148 5433 5441 6884 2966 2965 51616 6875 6878 83860 5434 6877 54457 5435 5437 2959 2958 6879 2968 2957 2967 1022 2963 2962 2961 2960 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence 4683 898 8370 25842 5925 9134 890 8900 94239 26277 25913 65057 7013 3013 7014 54386 255626 7157 10111 4361 3018 3017 54145 472 3014 8331 8337 8091 8334 8335 474382 8341 8342 8970 8347 1017 8348 128312 8345 1027 8340 55766 3009 3008 3007 7290 3006 3005 8338 3024 10524 23523 3159 57634 85236 8349 1026 4001 8290 29855 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair 197342 7516 10714 84464 7517 9682 51426 63979 23514 80198 5424 55732 57804 79008 165918 10038 2067 79728 1642 7158 5893 2547 54107 51035 22976 54962 151987 5531 25 8914 54145 472 6233 144715 5810 5932 11073 6117 7316 6119 6118 8341 8342 8347 8348 8345 8467 8340 1111 142 9656 7520 7334 10524 7336 7486 7518 9861 5429 5982 5682 5983 5683 5684 5685 5686 84126 5717 2237 85236 5718 5719 8349 7311 7314 11047 10213 3981 5713 5714 7979 5690 5691 5692 5984 3978 5985 5693 5694 5695 5883 8290 5884 5706 116028 5707 5708 5709 5687 7156 5688 5892 5689 4683 5700 7341 5701 8370 5702 5704 5705 890 8900 3364 6047 51588 10721 641 7329 6613 51750 63967 255626 7157 5599 8314 11200 10111 4361 3018 3017 3014 1763 5591 545 51548 80010 672 347442 5536 139425 29086 9025 5890 2070 9156 8924 51720 5111 322 84142 9577 79184 5889 2140 2139 8970 1017 128312 9978 83695 84295 580 51567 79840 55775 55183 9031 27343 64421 27434 83990 7468 23030 8451 5981 8450 2072 2138 56655 7515 5888 5425 5426 3838 348654 5427 10635 146956 675 3980 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle 8500 10815 6844 6616 5864 10497 9256 6857 6582 6580 4128 6571 6804 8541 8497 22999 8499 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling 5567 111 109 112 5568 113 114 115 196883 5573 5566 5575 5576 2778 5577 107 108 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C 27338 119504 246184 51434 51433 7321 983 5347 25906 11065 8697 7324 10393 29945 29882 996 51529 8881 64682 891 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells 342977 7852 639 8320 7022 64321 79923 5460 54790 9139 652 10630 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) 5699 5687 5688 50489 5689 5700 5701 5702 5704 5705 2209 4360 9861 5682 5683 5684 5685 5686 5717 5718 5719 11047 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 9902 5707 5721 5696 5708 5720 5709 5698 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism 3163 3162 1355 644 645 4363 1371 54658 1244 54657 210 211 212 213 2235 5498 3145 7389 1352 10599 7390 28234 2168 9429 2938 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 5928 86 57504 26039 8370 5931 94239 9219 1107 6760 9112 3013 1108 255626 3021 54815 3018 3017 54145 3014 53615 8331 8337 8334 8335 8289 90853 474382 5977 57492 8341 8342 8970 8347 8348 128312 8345 8340 55766 8968 60 8338 9274 605 9275 8110 1788 147646 85236 6601 8349 6603 8193 3066 3065 6602 6605 653604 6604 143689 6595 6597 6599 6598 57459 29947 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 29844 91603 10714 54891 79913 51426 50813 5424 54617 57804 9716 902 10038 10445 2067 404672 10920 1642 283899 83444 5886 4798 5887 54107 7507 7508 1161 5430 5431 5432 2873 5433 6917 8607 6233 27339 56949 1022 6117 7316 6119 5436 6118 5438 5439 1069 7528 8178 142 60 7334 7336 5982 5983 7311 7314 5984 3978 5985 86 4331 7341 8554 6612 7329 6613 10401 10450 5440 5441 2966 2965 7874 1643 5434 5435 5437 2968 2967 9318 57461 5111 2074 9978 2071 2068 57654 8451 54778 5981 8533 8450 2073 2072 64708 56655 85015 7515 9557 125476 51138 10987 5425 5426 10980 5427 93973 3980 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation 2247 2251 9982 83888 2248 2255 2252 27006 2254 143282 8074 2249 2246 8823 8817 26281 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 3659 5928 5929 6774 23476 6932 2033 3091 8370 5931 2146 4613 94239 9070 3013 255626 3021 4791 3018 3017 54145 3725 25937 3014 4790 58508 8331 10413 8337 8334 8335 467 474382 5970 2034 8341 8342 8970 8347 8348 128312 4780 8345 6934 8340 7004 55766 7003 7005 8726 8968 1387 8338 3727 2354 83439 2353 6772 8463 85236 8349 1499 653604 84661 11091 4297 23512 4609 51176 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation 2812 2815 2160 2814 2811 2158 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling 111 112 59345 113 114 115 6714 2793 2792 2771 2791 2790 2770 2782 2788 346562 2787 2781 2786 196883 2785 2784 5573 2773 2783 5575 10681 51764 5576 2778 107 108 5567 109 5568 3678 94235 2852 55970 5566 3688 5577 54331 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis 9100 7316 5111 6119 10714 6118 9768 124739 51426 5424 57804 54107 9246 5982 51455 5429 5983 9636 7318 7706 11201 7311 7314 6233 5981 56655 5984 5985 5425 5426 5427 6117 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 23556 5283 9487 9488 84720 54872 284098 5277 5281 5279 93183 51227 8818 55650 80235 54965 84992 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus 55746 23279 79023 10762 23165 6396 129401 9631 7175 3836 4927 8021 5903 9688 23225 3837 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 2262 221914 9672 6383 10082 2239 6385 375790 2719 6382 2132 2131 3339 2817 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 7157 27113 23368 5366 55240 7159 27166 637 147923 8626 472 94241 63970 7161 665 581 1387 10650 51499 84883 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER 29844 7316 54891 86 79913 50813 54617 10038 10445 9978 10920 1642 283899 83444 1069 5886 7528 4798 5887 7508 142 60 2873 8607 7311 7314 8451 6233 1643 8533 8450 64708 125476 9318 10987 51138 10980 93973 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA 6431 5356 9984 10250 22794 29107 3188 3184 57187 51362 9716 199746 902 7919 3192 84324 3191 84248 6427 3190 84321 6426 27350 9939 29974 6429 103 8896 10212 104 6428 164668 728343 403314 9877 200315 339 51213 10189 9582 84271 10930 65109 10084 80145 26097 8563 8683 8449 9775 10482 23350 9295 10569 9343 10921 11338 56259 2733 55110 79228 4116 80349 7307 3178 10946 25904 4670 4850 3187 10907 9360 10914 4848 5725 4849 27339 10419 83443 10644 10643 55571 246175 25888 9861 5682 5683 5684 5685 5686 55149 5717 85456 5718 5719 11047 10213 5713 23019 5714 7979 5690 5691 5692 5693 51001 5694 5695 5706 5707 5708 5709 5687 5688 5689 9337 5700 5701 5702 5704 5705 3028 57472 5580 11340 8570 9125 9261 23404 4839 3315 54512 3312 677 10642 7514 5578 55802 5393 7534 8741 29883 23016 8021 5073 140801 51010 22868 167227 9238 1981 51013 60493 207 3842 7529 118460 22894 1994 1432 56915 7538 8125 26986 54464 3304 5600 6418 11066 10772 11193 24144 8899 64852 55100 143884 51428 10081 23398 3550 9092 1975 22985 1974 55234 1973 55599 8559 58509 9924 1977 112858 6936 255967 8106 59286 79576 56339 58517 51690 51691 11157 79670 8233 79084 64895 151903 23318 10713 5511 55702 5514 5411 10605 6122 153527 60625 23049 6124 84811 6123 23293 6125 9887 55954 11017 55181 23381 9584 6631 55629 5976 9589 56006 154007 10929 6625 6626 6130 135295 6133 27258 6132 84950 9128 6135 9129 26017 10915 7737 6134 63932 6137 9130 4236 6136 51121 79706 57819 84081 25949 7884 79171 10073 4809 91603 6128 1207 1659 23658 6129 10171 55094 79050 27336 84916 6142 79165 10813 26121 163859 23160 6141 27042 25804 6144 55127 57721 54555 79753 22916 54433 55660 6143 7536 84128 6146 51202 51747 8602 23759 6147 92856 79622 65083 51634 11103 23165 6139 51759 4686 1736 6138 9277 25879 6152 9790 51096 6155 55651 9631 6154 55813 7175 5822 6157 27292 6156 5430 6159 56902 2091 6158 115939 5431 25926 5432 114049 6164 6166 27340 5433 6165 27341 10436 57647 6168 55623 55226 6167 88745 55505 6169 10199 23521 6160 9136 57050 22984 6161 55272 51077 10607 11056 6175 9724 6176 84135 134430 6171 51118 10885 6170 348995 6173 9883 57122 2963 2962 5436 55746 5438 6181 5439 23279 79023 10762 6396 8732 129401 8731 6829 4927 5901 27316 5499 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 4904 5520 5930 10128 81892 6832 25996 87178 51095 54931 9692 60528 55720 8780 54881 26168 81875 79159 51388 90459 8568 55759 705 79707 57418 23246 23481 26354 55131 81887 5515 84946 55781 117246 83732 10969 23144 10438 1797 124245 54439 91746 84186 5394 23211 64848 196441 10200 64282 64062 219988 23644 1656 196513 27257 116832 80153 2926 6434 200916 9045 23708 26019 2107 65110 51504 6233 2935 3183 1454 1453 7316 6230 6232 6231 79869 6234 6235 5500 387338 6227 6229 26995 51335 81554 6228 55178 79922 130916 84881 285367 29960 115024 9652 10767 28960 79760 5518 7311 7314 85437 54960 11224 6607 25873 8487 6188 6187 6189 6632 9349 6191 6193 6192 1479 1478 6194 1477 2058 6628 57794 6634 6633 6636 10262 6635 3921 6637 10236 23524 79833 57703 11218 23020 50628 2197 85313 9188 11044 9879 9410 140032 1655 11051 9416 10181 51602 51585 6201 6203 5093 6202 5094 51593 404672 84844 96764 8175 134353 8189 6210 51503 25929 51065 55696 6205 6204 6207 6206 6209 6208 6223 6222 6224 55596 84967 6218 51808 6217 4691 83640 56949 5546 11260 1653 79897 51367 1022 11102 10775 54913 80746 79042 51493 10940 339487 113179 79074 4234 10799 10557 51639 10179 8270 134637 283989 79691 283742 81605 10556 116461 54974 10248 55644 51645 55621 51637 51002 84267 81890 84520 152992 91801 57604 51605 54517 93587 115708 55006 90353 55687 63892 10291 84705 221078 54482 25821 64172 348180 51692 79693 23536 1787 24140 60487 54802 10283 54901 54888 8241 54920 10785 10286 83480 10285 22803 1660 1665 10284 84991 2521 81608 6499 10898 55339 80335 4331 22826 22827 54883 10528 11325 55749 23451 10450 5440 5441 10465 2966 2965 22938 5434 53938 5435 5437 23283 24148 2968 2967 53981 51340 57461 27238 27043 29894 51729 2071 51106 2068 10992 10523 10978 3181 3185 988 6627 6629 220988 23450 6638 10594 55253 55039 23517 57570 9836 127253 129450 4736 9785 6430 6432 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab 3320 2064 11140 55914 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants 2322 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm 8463 344022 6932 6469 1499 7004 8928 4087 4088 3170 10413 6862 3169 51176 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria 596 5533 7534 7532 637 7531 5534 7533 207 10971 7529 2810 10000 208 572 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 54492 7316 54567 2033 57534 5664 1272 5663 3280 3714 55851 83464 3002 100996717 84441 9794 28514 3516 55534 388585 4853 7311 182 102 7314 9148 142678 6233 23385 51107 2208 100996763 388677 10046 4192 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand 5111 6119 10714 6118 2237 5424 57804 23649 5422 1763 3978 5557 5558 5425 6117 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 347 389812 10999 3933 286256 28965 376497 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity 6844 6616 127833 9900 6857 22987 6804 112755 9899 6843 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 5436 4331 5438 5439 902 404672 2071 2068 8732 8731 6829 5430 5431 5432 5440 5433 5441 2966 2965 5434 5435 5437 2968 2967 1022 2963 2962 HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation 10855 4669 1514 3425 2262 3423 221914 9672 6383 10082 2239 6385 60495 375790 2719 6382 3339 2817 6448 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d 10195 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation 4148 197 718 375056 348 7018 5589 57719 255738 721 1000 351 7425 80341 3569 3490 8542 116519 5265 213 3895 10970 7466 6383 10232 8074 4241 1462 4052 5034 10130 2519 338 8720 3915 3486 1435 4221 3912 11167 51246 54757 8404 3491 91851 7184 3488 3487 2153 64856 10117 813 1114 258 2266 7857 5954 56955 29106 3270 10272 265 2243 1471 401138 51280 3053 56975 57104 3956 4924 7076 8614 4240 174 54972 3698 5624 84141 9210 11098 54587 462 5179 3827 51156 10618 2621 6694 334 2335 2200 1356 2719 6696 652 3913 5768 3371 11320 102 1758 3484 5611 335 336 147111 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions 1500 1006 1495 1009 1499 3728 64403 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase 840 999 5580 660 63967 2620 8428 118 51765 28988 4137 3146 2934 1829 100506658 3837 324 6709 6304 7431 836 5747 2339 841 5339 22985 3009 3008 3007 3006 5588 3005 1677 1676 3024 3148 3836 6093 1832 10059 5062 1499 10134 839 1830 5317 4001 1828 329 7082 9414 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 6907 4862 8648 6256 5054 96764 5465 10499 10498 23054 8553 1387 10135 406 56938 79365 28999 25819 2155 5469 85441 80205 6604 9575 79718 551 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling 10454 64127 11213 4791 257397 8454 6233 351 4790 5970 7316 7186 23291 841 4215 8767 4792 5608 7334 7335 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 3654 5714 7979 3656 5690 5691 5692 5604 5693 5694 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 54472 5705 3551 84166 92610 1147 51135 7850 8517 4615 10392 79155 79671 7157 246330 9097 3146 6285 1326 8878 6288 11274 6416 6283 9683 9684 4793 28512 57161 57162 177 23118 121457 28511 80216 3552 3553 9978 6885 3557 7189 3554 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression 51082 10849 6908 4331 30834 8370 902 404672 94239 3013 221830 8819 7343 8932 255626 5440 23309 5441 3021 2966 9533 2965 3018 3017 54145 3014 5434 5435 11176 5437 8331 2968 8337 2967 8334 9014 8335 1022 9015 9013 474382 8341 8342 84172 8970 8347 8348 128312 8345 8467 23378 25942 2071 8340 79685 55766 6839 2068 29115 8968 23411 8338 1789 1786 25885 79595 85236 8349 3066 3065 653604 51742 10284 64425 64426 7270 79101 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins 26508 6667 6663 4343 51129 192669 23112 27327 1006 26523 27161 192670 57690 1009 3728 64403 80332 1495 1499 80149 3224 6615 3609 2294 8728 28513 27319 56978 1500 9839 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers 80824 54567 9715 4040 5925 4041 3280 597 6238 51411 8496 1849 1848 1852 1850 5156 4627 54845 57599 8036 2251 50507 8087 253260 4193 4869 4067 23493 4915 627 9861 5682 23462 5683 5684 7039 5685 5686 28514 5717 3516 5718 5719 1499 11047 10213 5713 7046 5714 7048 1026 7979 673 7291 2475 5906 5690 5594 5691 5595 5692 5604 5605 5693 6654 5694 2254 5695 8074 5706 2249 5707 2246 10817 5708 8823 5709 8817 26281 4851 842 5687 5688 5689 5700 5701 3726 5702 79109 5704 5705 55615 8878 2322 64223 207 7529 8658 80351 3549 1452 9978 5573 471 83933 4893 4763 3265 399473 161742 200734 3164 5294 22916 5293 4686 55869 7175 7525 5430 5431 5432 5433 2963 2962 80853 5436 5438 23533 5439 4087 4088 4089 8503 5903 3815 4916 4908 7450 5664 2099 55851 9759 83464 9451 1147 7157 2266 3690 1213 2243 8312 51107 5519 324 5525 5515 5526 5516 5527 5528 139285 5529 2244 11140 55914 5245 6711 6714 5880 5728 613 23189 2247 55750 6464 182 4609 238 5777 5295 5296 10818 5290 5291 3667 4343 192669 26523 27161 192670 1185 57690 7040 3002 3845 1950 5335 2064 1956 8454 6233 7409 8826 3320 9061 7535 7316 1051 6934 5500 4296 10142 11116 891 5518 7311 7314 6500 5501 5170 6249 5894 572 10018 598 6774 5663 2280 391 10956 84447 51009 2534 6868 5155 118788 2323 930 5159 6801 84335 940 941 942 2264 6199 50852 23385 2931 9965 152831 9846 255324 5781 2305 6194 8546 55109 2335 1488 1487 7297 27044 408 10256 56829 2804 53335 6772 4140 102 7170 5495 7171 4170 5037 64840 51530 10000 11044 8660 11052 3932 9444 2803 6907 26508 22906 409 7855 83999 8322 8325 50616 8323 1523 208 3714 26127 2885 27436 399687 7415 3791 283455 9321 388585 57448 808 11221 5551 1445 7750 833 10342 3082 51564 5908 4233 2549 10013 10014 23164 374 6469 79885 369 1937 11160 3662 1024 9530 1387 2248 2255 10533 2252 27006 9734 89780 6777 6776 7249 27121 27123 1639 9148 142678 81608 22872 2932 54492 146850 80304 22866 57534 2033 2120 22808 55733 57674 54894 3717 3831 3799 5440 84441 5599 9794 5441 6400 55534 5601 892 7414 3725 22938 5434 5435 5437 3092 2309 79718 2308 8315 57085 5292 10046 9648 8841 9542 9208 27248 10827 3084 50846 815 816 8850 2069 817 7094 818 1027 685 2100 29851 79412 10718 1839 5879 867 1786 57670 145957 3674 22943 2263 2261 2260 3587 5782 3066 3065 4303 54518 8805 4008 2648 4000 3586 9612 4478 9611 8844 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin 3625 3624 10468 10272 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 2767 59345 908 6950 7203 2769 2793 2792 22948 2791 2790 2782 2788 2787 2786 2776 2785 2784 2783 10681 51764 10693 10574 10694 10576 10575 1460 9630 94235 6000 1459 8787 1457 8786 55970 9628 5082 54331 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo 261734 1856 6788 6789 7531 836 60485 26524 55233 9113 25937 92597 154810 7529 51421 23286 10413 7082 9414 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors 2898 2897 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation 8076 4052 7043 4053 650 4054 7042 10516 84467 2202 2201 2200 30008 8200 8425 4015 2006 4016 4017 7040 652 5045 3693 3678 3694 3685 3690 655 84171 27302 3696 4237 4238 4239 7448 2199 8516 2192 84695 3688 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis 57128 81894 2232 2230 81689 112812 51312 51218 150274 2395 122961 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 3084 10608 5664 5663 6714 5241 2069 11033 348 685 2099 3925 10718 1447 55851 6868 6387 83464 1839 6776 145957 2670 6285 51741 23118 23385 51107 10413 9611 9542 6678 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration 3676 6696 3683 864 865 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression 31 32 51085 10554 6945 2194 47 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling 7157 79671 7316 9097 7186 11274 9683 9684 7311 7314 841 6233 121457 3551 84166 1147 7189 8517 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors 2353 5594 1386 5599 5595 1432 5601 5600 5602 3725 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins 7316 5687 5688 5689 5700 5701 5702 5704 9978 5705 23291 26224 5187 8864 8863 1408 9861 1407 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 8454 7314 11047 6500 10213 5713 6233 5714 7321 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 284656 1212 5664 5663 2045 2044 2042 2041 2051 2050 2049 2048 2047 4067 2046 2534 55851 83464 5879 10451 7525 7074 8218 7410 1175 160 161 163 102 1213 1211 1759 4313 23385 1943 51107 1942 4318 1949 1969 1948 1947 2043 1946 285220 1945 1944 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 145482 8644 3248 9536 80142 5730 5742 127281 5743 873 5740 27306 10728 1582 6916 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation 6431 51585 3188 27336 3184 51362 5093 199746 5094 3192 51593 3191 22916 84844 6427 55660 3190 6426 6429 6428 4686 8175 6434 8189 8683 5430 5431 9295 23350 5432 11338 5433 7307 10946 3178 4670 3187 10914 6233 5725 83443 3183 2963 2962 7316 5436 51639 5438 5439 79869 5500 10291 51692 8241 10285 7311 7314 27316 5499 22803 1660 1665 84991 2521 81608 10898 55339 4904 22826 5930 22827 11325 55749 23451 5440 5441 5434 5435 23283 5437 53981 6632 10772 1479 29894 64852 1478 1477 6628 57794 8106 6634 6633 10992 58517 6636 10262 6635 6637 10523 64895 10236 10978 5511 5514 23524 3181 3185 9584 6631 10929 6625 6627 6626 6629 135295 220988 23450 6638 10915 9879 1655 11051 6430 6432 10181 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 5928 317772 6907 51143 85235 8370 5931 2146 1780 23165 1616 3013 9631 7175 221613 255626 1783 2002 92815 8969 8021 1956 440689 3018 8655 3017 1781 4790 79718 8331 1778 8337 348995 8334 9883 8335 57122 8841 140735 55746 8341 8342 8970 8347 8348 128312 8345 23279 10951 79023 8340 5371 10762 8726 6396 8968 129401 8338 4927 2874 85236 8349 10155 5903 9688 23225 653604 55706 23636 9972 11097 3688 23511 9612 8086 53371 8480 9611 79902 23512 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib 3320 2064 11140 55914 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions 5175 4067 5777 2534 5335 3685 7525 3690 5781 3932 3635 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 8500 10815 6511 6844 6616 5864 10497 9256 6857 27165 6506 6505 6507 57030 10550 2744 6804 8541 6512 8497 22999 8499 54407 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 2677 2158 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency 1585 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD 26503 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 2209 4067 2534 2214 2212 7525 2268 917 3055 6850 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism 2954 5092 3081 5053 883 3242 80150 5860 259307 6898 2184 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification 2767 59345 2769 2793 2792 2771 2791 2790 2770 2782 5321 2788 346562 2787 2786 2776 2785 2784 2773 2783 10681 51764 9630 94235 14 5028 1432 64805 55970 6915 54331 10672 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate 11181 8972 280 27159 1118 3938 278 6476 279 GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation 3768 111 112 59345 113 114 115 3773 2793 2792 2771 2791 2790 2770 2782 2788 346562 2787 2786 196883 2785 2784 2773 2783 10681 51764 107 108 9568 109 3760 3761 2550 94235 2774 3759 3772 55970 3762 3763 3765 54331 3766 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 593 594 1629 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling 53916 3082 4233 1398 1399 2549 382 5867 23163 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription 4088 7157 4089 864 7040 463 1026 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) 10568 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking 9554 9342 2801 2890 4905 10945 4627 9382 2060 920 4644 6810 6814 4641 1121 6712 1075 93661 7039 55860 51164 84516 53632 10671 338 81846 3630 5564 3312 2799 7534 5571 207 1777 7529 11154 8906 9179 134829 157807 11127 286 5867 5868 57134 4121 10905 5286 27243 55048 22878 22879 128866 89853 79090 221960 79890 84958 57589 2665 80006 2664 57465 23163 51762 23682 83874 10890 11345 8408 729873 79643 10260 6764 51652 9230 9909 84315 51256 160518 27095 163259 126432 51534 9363 81876 26130 3257 6305 27342 79958 9135 201627 338382 9525 125058 163486 382 54662 201475 51399 9267 55357 29082 9265 1122 9266 57533 8675 7109 27128 117177 11337 22796 250 6399 143187 5861 137492 11021 347517 84342 51560 27183 91949 79735 91782 9950 23265 25782 57706 25839 5872 25978 27314 5873 10228 51272 51271 378 11031 126003 60412 83548 58485 27333 57511 54536 23258 79961 9527 92421 9609 51693 10466 6396 26000 116442 8976 26088 1362 60684 10640 10226 122553 55738 11336 51160 23011 10981 5866 149371 84079 9827 374403 155382 22930 22931 10052 22898 57165 54453 375519 93343 57369 23062 55763 55667 7251 2702 27147 2701 8729 79720 2700 83696 5874 127534 8301 54734 2709 55770 2707 51622 2703 83452 219770 4943 259173 125111 89781 10804 23637 81025 9610 84694 64786 11015 3949 414918 8766 51112 128637 51510 23208 9185 9856 115548 1861 9183 8674 27348 23149 85439 9892 10113 22905 3267 10652 85021 3998 29988 950 143425 22848 4738 6572 286749 90019 55707 29978 29979 84251 51552 6456 1175 2153 160 161 163 26052 9570 1785 1213 1211 1759 6811 56894 22836 2157 6709 4646 57679 6711 8398 2590 636 23299 5321 5050 5049 2017 54874 10254 8533 64708 10987 51138 2706 2705 10980 1080 51143 50813 26119 23433 10920 11267 51028 84313 185 26958 10139 60592 55850 84316 400 51014 8677 1950 339122 23423 372 1956 10109 51542 7110 381 662 8655 6869 10244 23647 6233 79571 1781 9276 9712 90196 11316 6453 122830 1778 60561 60560 22818 154 6293 2800 1314 54732 1453 51226 738 10552 53407 22820 55275 140735 7316 51594 10133 11014 156 7532 1129 7531 8773 10093 8871 10092 4036 10094 10540 10097 4218 9871 10096 23048 9632 5048 8867 10427 288 7311 7314 81631 58513 1294 29924 10121 11258 2697 6844 4074 5864 6857 2589 917 10971 51422 23396 84364 51209 23256 966 9322 1604 2810 5563 5565 9318 255324 7037 7164 9026 10053 8775 388552 3482 7163 6272 10618 286451 8546 6643 157 162 51128 164 27131 81567 55330 2512 54885 152503 408 5869 9829 8673 127833 9685 9341 26258 2495 2647 8907 10717 8905 5878 84062 2804 51429 130340 9698 1176 1856 23431 64746 1174 2580 23557 8027 25977 1522 4124 10802 26286 10484 10000 9367 7082 50618 2803 6517 1212 7533 409 375056 112574 7018 23216 4253 9847 8322 57186 7474 11070 9882 1780 273 1523 208 274 11311 11252 29763 79058 57148 29993 1601 8218 2873 1783 4952 9321 351 808 375 377 10342 6455 6457 374 6836 5265 8774 23243 22870 2348 10175 10972 5537 7248 9117 11196 7249 64689 9585 23046 55291 24137 254263 1062 25956 55014 64837 81562 1639 26153 63908 8615 149111 9919 147700 90411 55605 10282 26984 79748 89866 10960 22920 55614 146909 22872 55582 23303 30011 29127 6708 10112 9371 6710 221458 9493 547 829 55083 81930 84643 830 4122 832 3796 3797 113220 3831 3798 3832 3799 3833 3834 5870 3835 90990 285643 57731 23095 10749 10959 3092 287 124602 56992 51332 89953 9648 11004 64147 1315 2069 685 1839 5879 3575 9146 867 7879 4012 5898 6845 915 551 554 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins 55801 10068 3603 3601 3600 1440 1441 7422 51231 1849 5657 1848 1846 1845 729230 920 6810 7186 356 841 3934 3689 4067 59067 4792 5608 9861 5682 2353 5683 5684 5685 3383 5686 5717 5718 5719 11047 10213 5713 7412 5714 1026 7979 2889 7291 1386 5690 5594 5691 5595 1399 5692 5604 604 5693 6654 5694 5695 5706 5707 5708 5709 79792 5687 5688 5689 5034 5700 5701 3726 5702 5704 5705 3977 9261 3635 3312 3636 7184 7534 8878 207 4507 1432 3552 3553 5600 3606 3562 3578 3559 3581 3558 7133 332 9978 5775 54014 51561 149233 5443 5293 7525 6175 4128 1234 4088 8503 6097 3929 246 1437 6095 3551 1147 8517 5478 7157 2162 5519 5515 5516 5528 9446 4582 5778 146433 2625 2247 6464 5743 2208 3688 3561 4609 5724 50615 3718 6616 5777 5295 3091 5296 5783 2185 5290 5291 3667 6655 5803 9655 595 7040 9049 240 8454 6233 7409 4790 3320 1436 301 5970 7316 3162 3569 7431 23291 8767 4985 6804 7334 7335 8945 5518 7311 7314 3313 6500 3654 3656 2357 5566 6382 821 596 598 6844 6774 3055 6850 2534 29110 3911 79923 84166 92610 51135 4615 10392 79671 84818 759 246330 9097 3146 6285 941 6288 942 11274 6283 9683 9684 1511 4793 28512 57161 57162 177 23118 6935 90865 121457 28511 80216 9173 9846 7076 5781 6888 836 2335 7297 6885 1052 7189 6773 6772 9235 4312 9466 1439 4170 9244 1438 3572 4313 246778 10148 4314 1901 4318 23765 8651 3716 8660 1154 6597 3932 3684 8835 10454 64127 1489 59307 11213 50616 5896 5897 3605 2885 112744 23529 58480 55540 5008 4791 257397 26525 11009 351 50604 948 84867 84868 386653 834 375 64806 26469 7124 6809 10538 27189 3082 5908 6813 6348 27179 27177 27178 6950 3567 3566 3565 4692 85480 3662 4215 5451 64109 3596 6777 6776 6778 6657 53833 53832 29760 998 11141 7132 282617 282618 282616 2939 6351 6352 6356 6347 6349 9180 6364 54472 829 6363 6367 1230 2919 1435 1271 1270 3717 6197 6196 2920 6195 4205 7850 4208 79155 2002 3576 5599 9252 1326 5609 466 6416 163702 5601 7867 5602 25930 5606 3627 3725 7006 2309 2308 5292 5598 84639 3965 9021 3976 133396 56300 200081 4988 26095 58985 132014 3563 1398 8968 3560 3557 3574 3687 3568 3575 5771 3554 3590 867 3589 4843 3570 3588 3181 5780 9987 5784 6775 8808 3185 8809 5062 3598 3936 3597 654483 3458 3587 6624 5898 8807 6845 5782 6647 1278 6627 6648 653604 4282 5055 4001 3595 3594 3593 3592 1072 27250 302 3586 29949 1265 5721 116379 4478 5306 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 5308 10370 7022 7020 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN 64840 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects 27338 119504 1019 246184 894 898 896 51434 1017 51433 5925 9134 1027 1028 595 1021 1869 1870 7321 1026 7027 25906 1871 11065 8697 7324 10393 6502 29945 29882 7029 996 51343 51529 8881 64682 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi 79694 57134 4121 10905 4245 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 5928 29126 5929 23476 3091 5931 4613 94239 4343 9070 192669 23112 27327 26523 27161 192670 57690 595 7415 4791 8454 91319 54145 25937 6233 4790 58508 8331 8337 8334 8335 8405 5970 7316 5133 8341 8342 7532 8347 8348 6934 4780 8345 8340 11160 7004 7003 7005 1387 8338 4751 9861 5682 83439 5683 2353 5684 8945 5685 8463 5686 79139 5717 85236 5718 5719 8349 1499 7311 7314 11047 6500 10213 142678 5713 5714 7979 53632 5690 5691 5692 5693 5694 5695 5706 5707 58505 2932 5708 5709 51176 3659 5687 5688 5689 6774 6932 2033 5700 5701 8370 5702 6048 2146 5704 91445 5705 100128731 10956 51422 51009 3013 5562 5564 255626 6400 3021 1460 6185 5571 3018 1459 3017 3725 6184 1457 3014 5563 10413 5565 746 80380 467 1603 474382 2034 27248 1019 8970 128312 9978 10613 55766 8726 8968 3727 2354 10331 84061 6772 7991 653604 201595 84661 3703 8452 11091 3716 10987 4297 1650 23512 4609 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation 84545 5018 78988 122704 92259 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 51073 118487 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 54998 10573 11222 128308 51649 9553 64960 63875 64963 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 64976 79590 64979 64978 23107 123263 28957 4528 64928 219402 7818 57129 51263 29088 51021 54534 51023 51264 51069 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation 2264 INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling 51561 149233 3594 5034 6775 6774 3593 3717 7297 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 5111 6119 10714 6118 5424 57804 4436 4437 4292 3978 5395 5425 9156 6117 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling 11069 7450 5908 5747 6714 7094 2335 9564 6850 1398 10235 10125 5770 3674 6464 2266 3690 207 2243 54518 10411 5906 1445 6654 5170 2244 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane 2157 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation 51082 2972 2971 6908 9328 9329 5451 10302 55290 55814 5440 5441 6621 6619 7702 6618 6617 9533 51728 27297 661 10623 171568 84265 5434 55703 5435 5437 55718 11128 10622 10621 112495 9330 2976 2975 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism 10073 1207 22916 96764 23165 4686 9631 7175 25929 54960 6607 8487 8021 51808 10419 348995 9883 57122 6632 55746 23279 79023 6628 10762 6396 6634 129401 6633 6636 6635 4927 79084 6637 79760 79833 5903 9688 23225 11218 55706 50628 23636 9972 11097 23511 8086 53371 8480 79902 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism 146850 25816 27124 30849 5294 5295 59339 59338 5296 5783 5290 5291 5297 79626 388121 5298 81544 9110 81846 5293 23396 9108 9896 660 3631 79153 3635 3636 8821 51552 55361 4952 5305 284161 65977 79837 55613 6305 375 56623 377 200576 51573 66036 54545 93492 64419 55300 23533 84725 22908 5728 7179 55697 8871 8776 57664 4534 80230 8396 5867 375775 10908 51763 8867 8394 5868 8395 126282 22874 22876 8503 5289 54477 8897 8898 54893 5286 23760 5287 90809 5288 133121 9107 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling 23421 11108 9138 5664 5663 9181 27237 23365 27018 6655 128272 11214 396 55851 3551 6868 83464 121512 1894 10451 5584 4615 5599 23370 25791 8878 7410 23229 50649 50650 9826 6233 9828 7409 4803 22899 4790 23385 51107 26230 6453 8997 8874 10276 55701 100271715 54848 5924 389337 8841 445328 9459 10672 5970 7316 84904 26084 836 7531 4168 55160 8767 2245 57580 7204 4792 5879 7189 57449 7074 387 4804 835 7311 9500 7314 26574 3066 3065 3654 29 6610 64857 89846 6654 23263 221472 9639 4099 57142 4974 572 10018 7984 84894 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability 7157 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers 5977 57492 86 26039 84295 6760 60 23506 65980 9274 605 29998 9275 64919 55274 55193 8110 53335 51412 6601 6603 8193 29117 6602 6605 196528 6604 6595 8289 6597 6599 6598 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 7533 10971 4343 51422 192669 23112 27327 57103 341947 26523 208 27161 2877 192670 57690 1327 5562 5564 9997 7157 1329 1340 7534 1337 1339 5571 64223 1351 50484 207 54541 1350 4697 7529 2810 1349 8649 1347 5563 1346 5565 1345 9167 84701 64121 10542 83667 7532 7531 4512 4513 143686 4514 389541 8626 5728 28956 10670 57521 153129 6009 5052 54205 10325 2539 7001 2821 125965 7248 7296 7249 9377 7295 55004 27165 53632 2475 10000 58528 613227 2744 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition 90381 79596 5520 2305 51400 4331 51451 1017 902 890 8900 993 5347 994 995 55320 55355 891 7514 28227 151648 5518 9133 9088 983 5519 79866 5515 7465 1022 5516 51343 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals 4495 84560 4496 4490 4489 4499 4501 4502 4493 4504 4494 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle 5295 27237 391 10652 392 3998 6472 396 10788 397 398 10451 10424 10298 143098 4983 857 7410 1829 9710 81624 23344 7409 23191 6811 6453 1795 8997 1794 7037 8987 2909 55914 9732 9217 26084 4162 4168 11135 80728 2010 4296 63916 3336 7444 9341 57580 1793 7204 26030 9743 57584 394 7879 3895 3930 55789 5062 55004 81839 80005 4722 998 26286 23592 1969 23141 23263 3688 5337 7112 3954 7984 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism 8659 5625 58510 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control 84545 5018 78988 122704 92259 65993 64981 10240 64983 3396 26589 63931 6182 54460 6183 51073 118487 116540 740 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 4706 64432 65003 64951 65005 65008 28977 90480 51081 6150 55168 64949 28973 65080 51642 54998 10573 11222 128308 51649 9553 64960 63875 64963 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 56945 28998 64975 64976 79590 64979 54471 64978 91574 23107 28957 64928 7818 51250 57129 115416 51263 29088 51021 54534 51023 51264 51069 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins 6844 79849 6616 6857 1938 2984 127833 928 10015 3326 1839 22987 6804 7296 5045 5609 6416 6843 808 3320 9900 5604 5605 112755 9899 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL 7316 5687 5688 5689 5700 5701 5702 5704 9978 5705 1855 9861 5682 5683 1857 5684 1856 5685 5686 51339 5717 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 59349 5690 5691 8452 5692 23072 5693 5694 5695 5706 5707 5708 5709 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) 5724 257313 1133 5731 5737 387129 1816 2358 1815 1814 1813 8111 2864 1812 8477 2922 6846 2925 10161 6863 185 623 624 56923 6870 134 135 2151 140 23566 2150 729230 3358 3357 3356 6865 2829 2828 6866 6869 885 886 9287 3363 887 3362 2837 3361 9002 3360 57121 338557 59340 153 3814 154 10911 155 2840 3355 2846 594857 83551 301 134864 3269 319100 134860 129521 9038 3354 128674 1132 2867 3352 2865 3274 2863 3351 2862 1235 3350 60675 1129 4922 11255 5660 4923 680 27334 84634 4935 5367 23620 3640 10316 51083 4828 4829 1240 9170 56670 84539 4985 4987 3792 1131 5729 27199 5739 2587 5732 4886 5733 5734 4887 4889 122042 2359 1269 2357 1268 5995 4543 4544 6751 5540 6752 5539 116512 54886 10022 6755 6754 8811 57105 339403 151306 136 163404 5697 10800 256933 79948 7504 27202 611 51289 10692 2652 9934 150 4142 152 8862 51052 9718 6288 727 728 5368 4852 117579 5030 53829 183 1903 6915 719 146 5179 147 148 9890 64748 6019 8698 53637 221391 8484 11251 23596 186 187 165140 2834 2832 2831 1880 2488 283869 2841 57486 2853 2852 4158 2859 50865 1889 2861 1901 64805 9283 9290 9294 59350 1325 2532 718 5443 1081 1524 5956 7852 351 6753 1234 6348 6010 2847 5196 6351 58191 6352 6354 6357 6356 1908 6347 6349 1906 10850 4157 1910 2826 6361 6364 9034 6363 4161 5473 6366 6367 1230 6360 2833 4160 643 2919 4159 10663 6373 3060 6372 347148 3972 6374 84109 6376 8620 6370 64106 1238 10886 2921 3062 57007 3061 2920 1237 3579 1236 3577 3576 1233 56477 1232 4283 2149 6346 2147 10803 51554 10563 3627 7252 7253 122876 170589 3973 2492 27198 8843 338442 3827 4986 4988 6387 5020 4295 7200 5021 7201 56413 5173 5031 5032 1909 94233 2798 2797 2796 1907 5028 151 5029 84432 1902 6375 1241 2693 6750 551 10874 552 29933 553 554 10887 1128 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) 10559 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses 138050 2990 2799 3373 4669 2588 3425 411 2720 3423 6448 NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response 7316 5687 5688 5689 5700 5701 5702 5704 9978 5705 1642 580 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 8451 5713 6233 5714 7979 8450 5690 5691 5692 5693 672 5694 5695 347442 5706 139425 5707 5708 5709 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants 673 5501 8036 22808 5894 369 5500 7529 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion 104 103 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement 730 731 727 732 733 729 735 1191 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 55315 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) 117608 5928 640 5929 4336 79862 7621 9968 650 30834 894 9969 896 340252 51385 902 171392 10445 7633 5925 148156 23314 79943 7626 7625 7627 3280 126375 374900 55762 79973 7638 348327 7652 57711 55778 10224 25925 7422 7257 163732 7247 2593 221785 374928 200845 148103 3064 694 79755 55786 80349 79759 140612 2101 4149 158399 10432 7673 5494 25937 10914 169270 463 79744 619279 30818 728957 84449 7678 117581 8784 7692 7694 5275 7697 84701 7699 112495 163227 9330 163223 2976 79088 2975 84676 2972 84436 2971 84671 9328 54807 9329 163255 23269 59269 54811 55900 5054 8317 11059 80095 10172 7004 9668 7003 7005 10498 201514 94039 5079 115196 23493 51333 126070 7025 26974 65988 405 25888 406 728927 6515 9861 23460 5682 23462 5683 286075 5684 7039 5685 126068 5686 374879 127396 28514 2811 5717 51592 3516 55713 5718 10168 5719 1499 9464 114907 11047 84838 10213 26152 163081 5713 374655 5714 7057 7979 7291 57474 5690 91120 5691 7050 5692 169841 83744 5693 163071 5694 83746 5695 390927 147837 7067 5706 1998 5707 1997 84626 5708 80264 5709 51176 1750 26149 4851 5687 63934 5688 163087 5689 79027 144348 3958 5700 60436 5701 3726 84874 5702 84870 5704 80032 5705 93134 199692 163059 2891 92285 92283 256051 341947 5915 5916 146713 341359 3977 349075 2660 163049 163051 4839 163050 654254 901 30832 65243 7514 79891 2669 79898 4605 7534 23619 65018 100287226 388536 10308 124411 10781 10780 207 4852 10782 162966 7529 100289635 388569 388566 388567 1432 388561 3549 284309 284307 400720 58500 5600 10520 4878 3562 3559 3558 147741 1378 253639 284370 115509 90233 1392 57677 3329 79230 339327 339559 9978 146434 26053 83737 353274 158431 57209 91584 7710 387032 27153 7703 4435 219749 10370 220992 5775 7712 442319 7711 79818 10138 266743 148254 5308 90827 7728 2290 23429 2737 7743 148266 2736 148268 80818 342926 23660 6886 7733 54778 7738 23439 730087 7752 6662 7753 2063 441234 55634 51276 353088 7745 56729 7988 7748 7884 136051 10127 7761 7760 91975 7762 114026 3164 339500 4004 4488 100129543 129685 6872 7755 4005 22916 6874 7757 6873 55888 23327 7770 8861 219578 7771 7773 4686 90874 162972 148213 3174 6749 148203 51058 148206 6881 7525 6880 55659 5430 7766 6883 7769 5431 55657 6882 7768 5432 730291 8148 126231 5433 55663 6884 579 6688 6917 10794 10795 7539 7552 51497 7551 9975 11198 6875 285267 6878 285268 50484 4287 83860 8812 7556 6877 255403 7549 57615 2959 90649 2958 6879 100131827 7561 7565 2957 7323 122809 7567 7566 7559 2963 8409 2962 94115 2961 7571 7574 2960 29959 5436 7568 54925 6921 8431 5438 7582 6924 7101 7587 5439 6498 6923 7586 6497 6258 84108 8427 7594 4086 7469 7596 138474 4087 4088 8178 4089 9534 7592 8732 142 126382 84333 8731 112950 199777 7122 6829 64750 4091 4092 8396 84124 2904 2903 6827 54715 5196 9310 8463 9150 3930 9314 440519 10273 440515 1025 162239 5901 181 54989 152687 51616 8013 8493 170960 57343 25920 125919 54457 147948 51224 147949 7936 9358 170959 26048 221400 80108 122402 80110 55124 221044 84944 6097 54456 342132 11022 285971 91646 7182 4800 4603 6096 113802 4801 1876 904 8468 4904 9271 905 1875 56165 4802 282890 136991 344787 92595 80139 168417 1649 79175 93474 84527 84765 57154 121340 58491 58492 1437 27300 59348 147929 340385 84775 1327 2289 1329 60528 1340 1337 1339 51728 27297 661 10623 1351 171568 1350 84265 55703 8312 55718 1349 11128 10622 5519 10621 1347 1346 1345 5515 5516 5527 5728 2625 5979 182 3172 613227 4609 639 4343 192669 23112 27327 26523 27161 192670 57690 595 861 6046 864 865 10135 7040 3845 5305 79047 7022 7021 83741 51741 339488 7020 284252 79837 7321 4790 25906 11065 8697 7324 10393 29945 29882 1436 996 27287 51343 51529 8881 64682 5970 27338 119504 1051 246184 1029 3569 6667 51434 51433 6934 23410 8575 6895 144233 57510 29102 3654 6241 5170 6257 10971 51422 857 2810 5781 6628 283 6634 6636 6635 6637 6772 9377 3276 10000 7082 2744 7533 208 58484 808 10628 834 6502 4233 83439 6657 1749 4602 7248 7249 898 9134 2624 2623 84441 9794 2626 55534 4853 161882 4854 4855 1869 3725 4778 22938 7027 7029 10046 9021 1019 1017 1027 7019 5442 64216 7978 5770 3458 6648 10769 25904 7222 4850 57060 4292 472 94241 4848 4849 117584 10419 144715 8649 5810 10650 5932 5933 5934 5395 11073 55571 28984 55215 6117 6119 6118 10542 80196 4194 8794 8795 8550 8793 8797 4298 1121 253260 389541 85403 22974 355 28956 356 4193 246175 6830 57521 4300 1111 6009 4869 5052 64065 9656 5588 8445 9891 9099 5608 10524 27125 7486 55840 8851 9540 627 7001 5982 5983 2353 2645 1263 23368 55240 84126 27166 85456 55367 55004 835 839 29117 64769 23019 1820 1026 53632 2475 1386 5594 843 5595 5984 5985 55677 604 58528 5883 5884 116028 124446 54971 5875 5876 10397 9212 7156 5892 9337 4683 7159 27154 10848 79109 133383 4436 890 5300 8900 3486 3364 79370 7161 26155 995 57103 7832 84289 1616 57472 641 55615 51499 3630 9125 7862 5562 5564 2177 2176 144455 204851 1874 26013 56950 29883 11200 10111 4361 5571 7994 64223 7874 54541 1643 1763 665 545 5325 80010 1647 25946 133746 672 79733 387893 317 5457 84883 5458 9156 64121 5111 8621 23774 83667 81857 8738 91875 28996 23405 4512 332 4513 147923 4514 143686 8626 6446 10670 83695 5371 63970 153129 580 112858 8106 581 3622 900 6720 51755 10325 51412 83933 10765 5978 80314 5443 1081 55170 55869 55193 6794 196528 8089 5467 54205 54700 54514 3815 7341 7376 7068 5241 6256 7421 5465 2099 7181 6095 367 4929 2908 9759 5468 7329 6613 5914 2516 7157 1460 1459 201164 1457 57104 11343 9441 51586 23175 6714 84295 284119 6722 2821 83990 7296 7295 84649 57678 2877 10555 5579 2064 1956 6790 8454 6233 3320 84962 4781 4782 6741 4784 7316 4774 7532 7531 79869 891 125965 5518 27165 7311 7314 6500 983 5566 55835 10018 27113 5366 637 5045 1514 1513 4697 1515 5563 10398 5565 1479 1478 9915 1477 8239 6696 55290 55814 4322 5105 9862 9188 6595 7562 4297 6597 285676 6599 11051 6598 29947 51082 51585 55683 6908 6907 57504 55689 8648 10891 51593 5931 9739 54623 348 404672 7695 7576 94239 22880 9070 729359 65123 1107 57508 123 80789 23054 26173 9869 134353 51535 55726 60481 8189 55756 65251 155054 64859 26512 1108 23248 22976 25896 7343 80237 162967 79035 25 10302 9997 5166 162963 79664 29128 29101 22936 7581 10514 81556 147686 6621 6619 54934 7702 11168 6618 9757 54815 6617 91661 55656 79871 9533 6940 23379 8202 54973 54145 92105 55596 84967 284306 51808 23272 55174 11176 57117 948 55197 53615 83640 58508 84524 9422 58490 8331 8337 8334 8335 1022 200424 1020 1810 8535 51562 84246 4773 26993 4094 197320 5977 51564 7913 10179 8341 23168 10013 8342 10014 8347 8348 6045 8345 79885 8467 23378 29915 25799 648 8340 79685 7528 84911 6015 6839 23466 79447 29115 1024 1912 1387 80312 1911 5451 10526 60 5452 8338 605 9734 9443 51692 259282 80012 57332 8473 8110 84733 9442 2494 25885 9440 23468 79595 57325 147646 84148 85236 6601 8349 6603 10155 9439 51105 6602 6605 6604 54737 22822 22823 10284 9572 64425 90809 125893 57693 64426 1050 81608 7270 79577 79101 2932 10898 147658 51230 55339 57459 123169 80335 10849 7700 86 4331 6932 6871 2033 26039 8370 51003 2146 2145 79813 284058 8800 9219 10499 51129 55729 9477 6760 9112 162655 4221 3013 90390 221830 8819 23451 6996 8932 10025 4208 255626 55617 5440 23309 5441 7069 3021 63924 91272 2966 892 2965 3018 100506658 3017 168374 2167 5816 3014 29028 5434 284459 5435 90317 5437 23283 155061 10474 2309 79718 2308 121536 10413 2968 121274 9646 2967 54487 9014 284443 2180 6910 9015 90589 8289 2572 53981 9013 9167 147694 90853 2571 8841 1482 474382 80778 9370 6929 26147 147687 10919 90338 57492 100129842 10001 814 11335 4986 29894 84172 815 8970 816 8850 4988 128312 817 2074 818 54790 22869 25942 90576 2071 90333 81931 2100 340602 285349 55766 1493 79611 353355 2068 81856 8726 1490 8968 6938 4023 100131980 23411 79788 3054 283337 26009 22835 9274 3683 9275 1021 90075 114787 9031 80317 29079 2539 146540 1789 84914 1788 10978 84924 1786 2538 57547 2874 2104 5346 57541 7767 2103 7403 3674 5469 3676 3720 3678 6319 90594 133522 1030 113835 90592 23067 146542 9282 847 8193 440077 3066 1278 3065 1277 112869 4303 653604 56242 143689 57573 55422 147657 51742 57336 84661 440073 10793 57335 2648 5888 11091 50943 5252 6750 23517 3484 9612 199704 30827 632 3991 389114 9611 51123 100170841 11105 23512 146198 8085 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria 5599 8655 10018 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling 4893 6654 8660 3265 3667 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation 389396 116285 219970 348158 92292 123876 341392 10249 54988 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency 10295 1738 593 594 1629 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 7316 10010 10133 9641 29110 7098 7311 7314 148022 7187 6233 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms 1857 1856 8324 5599 1855 1535 124056 10811 5879 3725 27035 7474 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants 2322 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 2515 7783 11085 2683 7784 8747 8748 22917 5016 6677 57829 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR 5111 6119 10714 6118 5424 57804 2956 4436 4437 4292 3978 5395 5425 9156 6117 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 1544 1576 1565 1571 3248 2053 240 1559 241 2948 246 5743 4056 4048 22949 1543 1558 239 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) 7099 929 3146 23643 2266 6280 7097 2243 7096 948 6279 114609 6271 695 10333 2244 4615 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand 51284 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 5977 57492 86 26039 6760 60 9274 605 9275 64919 55274 8110 53335 51412 6601 6603 8193 6602 6605 6604 6595 8289 6597 6599 6598 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling 55715 9260 5909 2549 5295 5296 10818 5290 9048 5291 64096 4902 5293 2675 1796 5623 2668 2887 53358 5567 5578 5568 8503 5979 5335 9046 6464 2886 220164 2674 9846 6654 5566 2676 8660 55816 5598 85358 5781 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) 23443 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis 84188 55711 158835 158833 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins 2589 10610 55568 84002 11227 11226 374378 51809 9334 9245 9331 168391 63917 51146 51301 50614 8693 442117 374907 64409 93010 84752 140687 114805 2650 192134 117248 146712 26290 2591 143662 57452 79623 118430 2590 10164 4582 4583 6483 4584 79369 6482 4585 6484 4586 200958 6487 10678 727897 10331 29071 6480 256435 27090 10071 94025 140453 4588 4589 56667 283463 56913 394263 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation 3784 10142 3753 3757 9992 23630 3741 23704 10008 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses 7316 3442 6921 3441 3440 2033 5610 3439 6923 9978 7297 3452 3451 64135 3449 1387 57506 3448 23586 3446 3445 3444 3443 6773 3456 3454 7706 3661 7311 7314 6233 8065 3716 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors 1387 8089 2033 4435 10370 7022 7021 83741 51741 339488 163732 7020 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 1029 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria 549 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 4851 3955 4853 4854 4855 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization 9402 3937 3708 3709 5534 4775 5336 3710 6850 4067 5530 10451 5532 10768 7410 5335 7294 7409 808 7006 6654 3702 695 4772 4773 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands 351 2357 6288 2358 301 2359 50865 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA 22822 6790 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation 35 4706 37 58488 4594 5096 3033 80724 1622 10449 84693 5095 641371 84129 11332 27349 1892 3032 3030 1632 55856 142827 134526 26027 414149 6296 117145 23597 284486 84320 166785 1666 10965 33 34 80221 51102 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells 5687 5688 5689 5700 5701 5702 5704 5705 3551 1147 8517 5579 8454 4793 6233 4790 5970 7316 23291 6885 10892 84433 4792 8915 4794 9861 5682 5966 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 56165 136991 8370 94239 192669 23112 27327 26523 27161 192670 57690 3013 7257 5430 7247 5431 255626 5432 5440 5433 5441 60528 3021 3018 3017 54145 201164 3014 5434 5435 3320 5437 8331 8337 8334 54487 8335 474382 5436 5438 8341 8342 8970 23405 8347 5439 8348 128312 8345 8575 8340 6895 144233 55766 57510 29102 283 8968 10526 8338 54514 85236 5901 8349 653604 143689 221400 122402 55124 84944 54456 11022 91646 4603 113802 8468 9271 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m 22845 ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI 79143 79887 26279 255189 30814 8399 81579 5320 5321 5322 283748 8605 22925 11145 5319 64600 123745 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs 3460 5594 5595 3717 3716 3458 5894 3459 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction 89 4632 4633 4634 4635 7431 7125 7134 7136 7135 7138 7137 7140 7139 7273 7169 29766 7168 29767 29765 1674 88 4703 7170 1756 7171 4606 4607 4604 8557 4621 4624 4626 7111 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 2956 4436 4437 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV 2998 8908 2632 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR 94005 8733 80055 128869 5329 51604 10026 CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport 6514 6517 154091 155184 144195 66035 55974 29988 6527 125206 56606 91749 11182 6524 85414 6523 81031 200010 6513 26291 6515 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 5034 338 4547 344 8720 345 348 51360 338328 9388 3931 51129 4023 116519 213 84699 5046 5045 91289 55908 9619 3990 5125 335 1071 336 319 64788 27329 337 4018 26291 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase 23421 51143 64105 8655 6233 7321 1781 25906 11065 8697 7324 10393 1778 29945 29882 996 699 51529 8881 64682 7316 27338 140735 119504 246184 25936 9793 51434 51433 10383 10382 23332 6232 79980 54908 5347 22919 7846 5048 9861 5682 891 5683 151246 5684 9735 5685 5686 5717 5518 5718 7277 5719 9133 7311 7314 11047 10213 5713 5714 7979 983 220134 5690 57082 54820 5691 5692 5501 23141 5693 5694 5695 6249 5706 5707 5708 5709 9212 5687 5688 5689 5700 5701 54821 9184 5702 5704 23122 991 5705 4085 701 55920 7514 3842 11243 11130 332 55839 8379 55166 79019 260334 6683 9798 200014 347688 79003 55055 22933 81565 147841 401541 378708 27243 1780 23165 79172 128866 9631 1783 83540 79643 80152 1104 51652 3619 64946 8815 348995 9883 57122 29082 55746 113457 27183 91782 23279 25978 7280 79023 92421 6396 129401 10376 80086 3930 5905 1062 5901 51807 5903 9688 10381 23592 112714 55706 23636 84790 23511 53371 79902 84617 5520 25909 7341 9183 347733 7278 79861 81027 81930 9232 7329 84643 3796 57405 10403 80776 3837 23047 5519 113130 9700 23244 5525 5515 23063 5526 5516 5527 7443 11004 5528 221496 5529 91687 57551 79682 2010 2491 55143 9126 10735 10726 10274 8243 1063 1060 151648 5885 1058 4001 348235 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6128 6129 6201 6203 6142 6202 6141 6144 22916 6143 6146 6147 6139 4686 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 23708 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 2107 6160 6189 1981 6161 6233 6218 6217 6175 2935 6176 6171 6170 6173 26986 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 6235 6227 6229 6228 3921 6122 6124 6123 116832 6125 7311 5976 6130 6133 6132 6135 2197 6134 6137 6136 140032 51121 4736 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors 257313 387129 2358 2922 6846 2925 6863 185 623 624 56923 6870 2151 2150 729230 6865 2829 6866 6869 885 886 887 2837 9002 3814 10911 594857 301 129521 128674 2862 1235 60675 4922 5660 4923 680 84634 5367 23620 3640 10316 51083 4828 4829 84539 4985 4987 3792 2587 4886 4887 4889 122042 2359 2357 6751 5540 6752 5539 116512 10022 6755 6754 8811 339403 5697 256933 7504 27202 51289 4142 8862 51052 9718 6288 727 728 5368 4852 117579 183 719 5179 6019 8484 186 187 2834 2832 2831 283869 57486 2852 4158 50865 1889 2861 9283 59350 1325 2532 718 5443 1524 7852 351 6753 1234 6348 2847 5196 6351 58191 6352 6354 6357 6356 1908 6347 6349 1906 10850 4157 1910 2826 6361 6364 9034 6363 4161 5473 6366 6367 1230 6360 2833 4160 643 2919 4159 10663 6373 3060 6372 347148 6374 84109 6376 8620 6370 64106 1238 10886 2921 3062 57007 3061 2920 1237 3579 1236 3577 3576 1233 56477 1232 4283 2149 6346 2147 10803 51554 10563 3627 3827 4986 4988 6387 5020 4295 7200 5021 7201 5173 1909 1907 84432 6375 2693 6750 551 10874 552 553 554 10887 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses 115004 23220 4361 3661 3428 51428 340061 147945 11277 197358 2547 5591 7520 29110 6737 6778 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins 7341 8370 23314 8554 1107 23165 6612 9759 7329 9631 6613 7175 8021 348995 9883 57122 8535 55746 6304 6045 23279 79023 648 6015 10762 6396 1912 7703 1911 129401 80012 4927 57332 84733 23468 5903 3066 9688 3065 23225 9189 55706 23636 9972 83746 11097 23511 8086 53371 8480 79902 23512 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome 3162 114548 7295 4791 4210 24145 9051 29108 4790 351 10910 10628 5027 834 3326 5970 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A 2588 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 5928 23090 57504 8648 10891 5931 3192 7350 6256 5465 4086 9219 4089 1107 9112 5468 1108 133522 54815 3066 655 3065 83401 64641 53615 1149 1346 63976 57459 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 9843 30061 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus 675 7979 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A 1594 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex 5436 4331 5438 5439 902 404672 22916 2071 7469 2068 4686 6829 5430 5431 6827 5432 5440 5433 9150 5441 2966 51497 2965 25920 5434 5435 5437 7936 2968 2967 1022 2963 2962 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 3815 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs 246 239 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression 940 VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction 4836 5145 8644 23173 338 5158 5148 9626 344 345 151056 348 50700 6011 29967 4647 221914 2782 9672 2239 3000 375790 611 64220 2652 2979 2978 5949 5959 5578 5956 388531 2986 79823 285440 53630 2262 1645 5957 808 7804 55937 121214 158835 2817 5950 2779 6295 5948 51109 1259 83875 6010 9227 5475 3292 2342 2339 2792 338328 7276 8630 24 1109 4035 5947 4036 4023 5588 145226 6017 2719 54884 3339 1208 9397 1258 10988 26020 10170 9249 3949 157506 6383 10082 57016 6385 5406 8608 335 6382 336 9187 337 6121 131890 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 55788 5826 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle 9497 94134 65124 4162 5295 1729 5296 80728 54509 8773 392 87 9341 60 9743 57584 8776 832 445582 394 1730 7879 55240 26092 857 55789 26049 29843 9590 81839 120 81624 23344 10409 4001 55971 80115 23380 4650 85360 7112 10160 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA 25942 3065 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation 5928 23090 57504 8648 10891 5931 3192 7350 6256 5465 4086 9219 4089 1107 9112 5468 1108 133522 54815 3066 655 3065 83401 64641 53615 1149 1346 63976 57459 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases 5928 23194 902 993 994 6790 8454 9662 8655 7840 6233 11064 1781 3320 22994 22995 7283 1778 10733 80321 203068 55722 1022 84962 1454 51343 1453 55125 5577 9814 7316 9738 10133 3161 91750 11190 286826 9793 132660 7532 55957 7531 10383 10382 23332 115106 22974 79441 95681 23291 1069 5500 5347 22919 54801 10142 7846 9702 10540 5108 4218 4659 11116 4751 5048 55142 9861 22897 5682 891 5683 54930 5684 8945 5685 5116 5686 79959 80184 5717 5518 93323 5718 7277 5719 9133 7311 7314 11047 6500 10213 23354 5713 22981 5714 8481 7979 80254 1026 983 22822 121441 5690 55755 5691 54820 5692 10806 79866 5693 10121 5694 5566 5695 55835 7465 55559 5706 8636 5707 11258 84131 5708 4957 5709 5687 5688 5520 4331 5689 2033 5700 5701 5702 5704 5705 890 8900 995 3326 55320 55355 7514 7157 4605 1869 1871 5519 5515 5516 90381 79596 2305 51400 51451 1017 63943 51512 9978 80028 1063 28227 151648 728642 984 9088 114791 85378 10426 27175 653784 29922 27229 440145 10844 80097 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway 5321 5594 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade 4836 5145 2779 6295 23173 5158 6010 1259 5148 9626 5475 2342 2339 2792 6011 2782 3000 5588 2979 2978 9397 1258 5578 388531 10988 2986 79823 5957 808 131890 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions 23428 682 23759 9056 9057 3675 6520 23657 56301 11136 5478 9123 6566 857 3655 23539 8140 4312 6693 481 482 483 3688 3897 4099 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis 1355 1371 2235 5498 3145 7389 1352 7390 9429 210 211 212 213 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 2767 59345 5296 79109 5290 5291 4323 2782 5293 2534 2776 5586 55615 10681 133 3791 5175 9780 4846 7414 24145 64223 207 59341 808 84290 2324 824 5577 826 1003 111 112 113 114 115 7094 253260 2793 2792 2791 2790 2788 2787 2786 196883 2785 2784 10266 5573 2783 5575 51764 5576 2778 107 108 5567 109 5568 10203 1499 94235 2475 5029 55970 5566 5170 54331 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation 8528 4967 1610 5827 92259 8659 2806 54363 64902 112817 275 2731 27232 1738 9380 58510 189 1743 2653 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis 50618 1212 50813 26119 409 10920 7018 112574 8322 7474 273 274 11252 29763 185 29993 1601 2873 8218 4952 1950 1956 10109 6869 6233 26130 2060 6453 920 154 382 6455 10552 7316 6457 156 374 1129 10093 8871 10092 4036 8976 10094 10097 55738 10096 23048 8867 7039 8301 7311 7314 58513 3949 29924 30011 23208 9185 9856 4074 6844 115548 1861 8674 338 6857 27348 23149 85439 9892 22905 917 3267 85021 29988 950 143425 22848 4738 6572 23396 286749 90019 55707 29978 29979 84251 3312 6456 1175 160 9322 161 163 26052 1785 1213 1211 1759 3092 9318 255324 7037 9026 3482 10618 157 2069 685 408 9829 5869 8673 9341 127833 1839 5878 2017 9146 3575 51429 867 5868 1856 2580 8027 54874 25977 6845 10254 8533 915 5286 64708 51138 10987 551 1080 10980 554 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 9212 4336 6907 2891 4343 192669 23112 27327 26523 27161 192670 5468 57690 2289 2593 4208 3064 7222 5816 808 79718 54487 2572 2571 8841 4233 814 1392 4986 28996 815 816 4988 817 818 25942 6446 5728 5775 114787 5770 2904 627 2903 6515 54715 2874 6657 3930 2290 28514 3066 3065 3654 5566 6750 9612 9611 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 53632 1432 5563 5565 10891 5571 5600 5564 6300 51422 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System 3784 6511 6616 10021 3780 2911 3782 3783 5802 348980 57657 2915 610 6506 6505 6532 6507 81539 23136 9463 7102 2892 6512 2890 23426 6540 18 10060 4905 10211 140679 1739 7915 54407 5579 80852 3781 8496 2036 6529 2893 3741 9132 80331 64130 3745 5330 3747 5331 5792 56666 5577 4193 3767 27163 10550 6804 3790 57622 79414 57497 78999 6812 9424 3775 10089 27165 53632 5594 5595 6833 5566 5170 6571 8541 8497 22999 8224 8499 8500 28964 10815 6854 6844 6853 5864 10497 6857 27345 10242 2891 51422 6582 27094 6580 3778 346562 3779 57030 341359 60482 2773 5562 6539 5564 3770 3312 6538 338567 83795 5578 89822 54207 3776 56659 50801 23229 5571 10645 5563 84254 5565 8536 3750 3751 3752 773 777 111 112 113 114 115 783 784 9546 22839 3758 26037 22871 3764 9066 57502 57669 196883 58512 127833 10611 91683 5573 321 57596 5575 26045 5576 2037 2035 57555 9229 9369 107 54413 108 9454 5567 9455 109 347731 5568 347730 9379 9456 22829 88 3760 22941 3761 80059 2550 50944 3759 3359 55327 200909 3772 1742 2562 2561 2560 2559 2558 2557 2556 4893 83988 2555 1741 7881 2554 2744 3737 56479 1740 26960 3265 3838 3738 3762 3739 3763 81033 3754 3765 3755 3766 131096 3768 3756 2570 2569 3736 55584 23416 2567 9312 2566 90134 3773 93107 8825 23415 9196 4900 2752 4747 169522 55879 3748 9647 3749 170572 170850 2771 8573 27012 2900 27133 2743 2770 3742 3787 2742 2741 3743 3788 2906 2905 3744 2902 3746 2901 5582 285242 200959 22843 320 27330 116443 1146 1145 57554 1144 116444 9568 27020 89832 8514 9177 8001 2899 2898 2897 2774 5923 24145 808 781 782 4128 785 57576 55799 774 5924 59283 1138 1137 1136 10313 1135 1134 23236 10369 8973 27092 1143 1142 1141 10368 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 2904 2903 10052 217 57369 9256 9254 94235 84694 11141 81858 55970 2319 4916 3785 3786 54331 59345 2782 143425 1312 6572 6531 10681 6197 6196 6195 28988 26251 22865 160 590 220074 2572 4646 2571 85358 3084 1103 814 815 816 5613 6714 817 818 26050 5879 3777 51305 43 9378 3757 8495 94030 114798 9495 84631 5789 84189 139065 26280 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse 3123 3122 3120 3119 3118 3117 917 3115 3113 915 916 3127 3126 3125 920 7535 26191 3932 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 328 4913 4968 4350 8930 23583 6996 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine 4968 8341 8342 8970 8347 8370 8348 128312 8345 94239 8340 55766 26277 25913 65057 7013 3013 8338 7014 54386 255626 55247 85236 8349 4350 3018 3017 54145 3014 8331 8337 8334 8335 8290 474382 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR 4790 23385 51107 55851 5664 83464 6868 5663 4804 7189 5970 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination 7316 8549 55366 340419 84133 4040 7311 84870 7314 7855 4041 8322 6233 284654 8325 8323 59352 54894 89780 9101 343637 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 10723 10568 6569 6558 142680 9497 9990 6521 8671 65010 5172 115111 115019 1811 9498 23382 83697 6522 6557 57835 6508 57282 6559 284129 6575 1836 160728 6561 6574 6568 10861 26266 57468 6528 6560 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors 57678 5295 5296 5290 4343 192669 23112 27327 26523 27161 192670 57690 595 861 865 200845 1950 1956 5590 3320 27329 340665 1592 6667 10498 10524 2353 7039 1382 2172 2171 1386 5594 5595 5170 124 596 126 127 341 346 6257 5481 346562 5915 5916 10728 3326 2773 56603 1509 7514 6801 340481 10062 857 207 1903 127933 255324 55625 858 4435 112724 5105 23030 10170 3276 4313 9249 8854 64577 4314 157506 1381 4316 10000 220 4318 8050 10901 4893 195814 57665 8608 3265 3838 1655 55818 6908 6907 9682 8644 8648 344 348 2771 94239 2770 54659 208 5430 5166 5431 5959 5432 19 5433 5162 5163 5164 8202 5165 54145 808 5160 2958 5161 8331 2957 8337 8334 8335 221656 2963 2962 5436 5438 8341 8342 374 8347 5439 8348 8345 6258 2793 2792 2791 8340 2790 7528 2788 2787 1738 2786 1737 5467 347 1387 2785 2784 5451 8338 2783 51764 2494 216 4602 8503 85236 1025 8349 94235 55970 23028 7090 904 54331 59345 2033 7376 8370 5241 6256 2099 3480 10499 2782 29116 3013 10681 8877 5914 2289 255626 2002 5440 64241 64240 5441 3021 4846 3018 3017 3725 3014 5434 5435 8312 5437 2309 79718 80820 9619 1071 5536 10123 8841 474382 5747 8970 6714 51109 8850 128312 2069 1027 685 2100 55766 51523 9126 8968 2288 8204 6387 6722 7764 10735 1839 2625 3727 3169 2354 9166 9687 23189 10274 7033 2874 8243 5346 7392 7391 7031 5469 5885 6319 2194 3065 653604 9612 9611 4609 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events 3708 3709 64407 2358 1815 846 1814 3710 5996 5998 5999 623 624 10287 56923 134 8490 140 23566 729230 353299 3361 5330 57121 5331 5332 59340 2840 3355 301 5726 5577 129521 3354 1132 3352 156 5137 3351 1235 1129 5660 5367 10316 51083 26575 338398 9170 56670 84539 10636 4985 4987 27199 10768 2587 5518 4886 5733 4887 4889 2359 26086 1269 259289 2357 1268 259287 5594 259286 259285 5995 5566 4543 4544 259294 259293 259292 353164 6751 259290 5540 6752 5533 5539 259296 259295 10022 5153 6755 5136 6754 8811 84152 339403 85397 346562 8601 5697 2781 256933 5580 2773 611 126006 51289 10692 2652 9934 150 152 8862 5578 6288 727 728 5368 5141 5143 5144 4852 117579 54429 5030 6001 53829 6002 10645 183 84254 1903 719 80835 80834 5179 111 112 113 114 115 8698 2918 2917 2916 2913 53637 2912 9560 221391 8484 196883 11251 23596 186 187 5573 5575 165140 5576 50835 2778 2832 2831 107 26166 108 5567 1880 109 283869 5568 2841 29899 2550 2853 2852 50865 63940 2861 64805 9283 9290 9294 1325 26960 3838 5534 718 5443 2771 2770 1524 5582 5530 5532 2780 5956 9568 7852 2774 351 808 1020 6753 1234 2914 23236 6010 2793 2792 2791 2790 2788 2787 2847 2786 2785 2784 2783 51764 5196 83756 50831 9630 50833 94235 50832 50834 6000 50837 5499 8787 50836 50839 8786 50838 55970 9628 50840 6351 58191 54331 6352 2767 6357 59345 10850 2826 6364 2769 6363 5473 6366 1230 2782 6360 2833 643 2919 10663 2776 6373 6372 6374 6376 10681 6370 2921 57007 2920 1237 3579 1236 3577 3576 1233 56477 1232 4283 6346 10803 10563 3627 5519 5515 27198 5516 8843 5528 338442 3827 2779 814 4986 815 816 5613 6714 4988 817 818 5321 6387 431704 5173 6003 6004 151 1902 6750 10874 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription 5925 85437 1655 7428 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME 6580 161823 9429 22978 5105 5243 124 6582 6581 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle 27338 119504 1019 246184 894 898 896 51434 1017 51433 5925 9134 1027 1028 1616 595 1021 546 1869 1870 7321 1026 7027 25906 1871 11065 8697 7324 10393 6502 29945 29882 7029 996 51343 51529 8881 64682 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT 5929 4040 7855 4041 83999 94239 8321 8322 9070 7474 8325 8323 7471 208 6259 864 2535 343637 83595 8549 8295 55366 51339 25776 9757 440193 340419 8607 84133 9580 6658 54145 6659 6233 284654 59349 56998 59352 55553 23072 8331 8337 8334 8335 9101 1454 7483 6423 11197 6422 7316 50964 8341 8342 8347 8348 6934 8345 8340 1387 8338 64750 89780 10524 9861 5682 83439 5683 6657 5684 8395 8945 5685 5686 27121 5717 5518 27123 85236 5718 5719 8349 1499 7311 7314 11047 331 10213 5713 5714 7979 5690 5691 5692 5693 5694 7088 5695 7089 8290 5706 79577 5707 7015 2932 7091 5708 7090 9736 5709 123169 51176 607 90780 8313 5687 5688 283149 5689 26108 6932 2033 5700 5701 8370 5702 5704 84870 5705 54894 1455 4221 3013 255626 7514 7534 857 3021 1460 3018 1459 3017 207 81847 1457 3014 8658 8312 80351 23401 5519 324 10023 5525 5515 5526 7473 5516 5527 5528 139285 5529 474382 7479 7478 8970 1452 128312 9978 1487 55766 79412 8968 1855 57680 1857 1856 22943 64321 54361 3065 653604 6662 84661 8452 11091 6597 6736 4609 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 983 5347 9133 91754 140609 10783 891 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry 5928 5687 5688 4331 5689 5700 898 5701 902 5702 5704 5925 5705 9134 890 8900 993 994 208 595 1874 4149 8454 1869 207 6233 7027 6502 7029 1022 5934 51343 7316 91750 1019 286826 132660 55957 1017 1027 5753 9861 5682 5683 5684 5685 5686 1163 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 1026 7979 91768 5690 5691 10000 5692 5693 5694 5695 7465 5706 5707 5708 5709 4609 1875 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 640 5777 3708 3709 5295 5336 3710 6786 80228 6850 84876 5293 4067 2534 27071 118788 930 4690 933 10768 973 974 7220 29760 7409 808 6654 695 30011 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants 5518 1452 1499 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib 2542 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions 353189 10599 53919 28234 6579 28231 11309 6567 551 6578 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs 240 246 5743 239 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis 23428 58494 5051 197 9056 9057 4072 23657 9463 56301 7102 7422 11136 5657 7222 7225 1191 7804 5581 6810 6814 57113 8795 5660 8793 8797 5054 3689 4067 6520 5588 10235 10125 8832 2811 135228 7057 5906 5594 5595 6654 5152 5153 27154 338 5136 1048 2977 10846 2983 27345 2982 10242 5138 4842 50940 27094 3778 3779 10335 5580 634 3635 5578 7534 22915 207 1432 5025 11127 5573 5575 5576 3673 8515 2778 5868 5567 5568 88 4893 3265 5294 1675 23759 7525 23533 3512 80739 51206 10630 213 5196 8503 5874 226 11069 7450 7043 11093 7042 2316 5478 7157 3309 5175 2155 2153 2152 3685 2149 4846 2147 710 2266 3690 5197 7056 2243 2165 2162 3053 2161 5519 2160 5270 2159 5525 11343 2158 5515 2157 5526 5104 5516 8858 5624 5527 5627 5528 10544 5529 57126 2244 462 2812 3827 51156 2815 2814 5747 5345 6714 3273 5023 5880 5024 6281 5271 9127 5026 5269 22953 5327 6786 5328 5329 80228 84876 10257 51706 5321 7441 440533 914 5670 5671 5672 2625 5673 6401 90952 5675 5669 5680 972 9123 29802 6403 5676 5678 6404 8527 8525 7010 2734 3543 8526 9046 83953 6464 23539 284 8140 285 2995 2994 2888 962 51378 2993 6693 83692 7066 51744 4352 6609 5028 151 3688 26090 57406 4099 3705 5777 3708 3709 5295 81 5296 5290 5291 3710 7273 160851 10451 1609 1608 747 1607 7040 5216 5579 1606 2151 7410 1950 5335 5590 221955 7409 481 9002 482 483 5583 5577 10672 5336 139189 9162 8654 6402 5739 5518 7277 3655 1525 14 6383 10082 6385 5566 5170 6382 120425 5894 4267 3442 3441 3440 388 50848 3439 54210 2268 391 6850 221914 9672 3452 346562 3451 2239 3449 2534 3448 2773 3446 3445 3444 5155 2 3443 150 152 5267 350 3456 94121 8407 51097 857 23052 9749 54495 813 7114 3671 66005 2262 7123 29106 83706 3818 10184 51571 3699 54863 7044 10490 29789 51368 51266 5552 7076 22927 2277 10916 6915 7078 7873 2817 5099 1521 2768 6414 5781 308 3700 5341 203859 3959 5340 54676 3937 1893 259215 78991 9948 6694 7424 7423 334 2335 5919 682 55664 374354 10447 87 960 408 3479 2719 3339 961 5593 140885 4312 55423 64805 335 3932 3684 1 4973 409 7018 2771 196527 2770 11311 375790 5582 1084 25 5004 5005 3672 2886 351 808 948 487 488 5027 1445 489 6543 6546 6547 490 491 492 1020 493 6717 3082 5908 6813 85440 7975 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 51764 5265 23468 4602 9585 23046 12 24137 1062 9630 64837 94235 10019 26153 10938 80005 147700 998 55605 55604 91768 221037 139818 55970 22920 55614 146909 55619 7465 3660 3897 55582 23303 23028 29127 10112 54331 3659 146850 2767 8165 9371 59345 221458 9493 25970 547 10362 51317 11216 2769 829 9927 5473 4097 55083 3046 3045 2782 81928 3043 23764 81930 2624 2776 3717 2623 84643 830 10487 10681 832 3796 3797 113220 3831 3798 3832 3799 3833 3834 6566 2627 2626 3021 10461 3835 90990 285643 161882 23414 7414 23095 10749 3048 3047 4778 50808 81704 23348 124602 56992 1795 23186 1794 3920 30846 30845 89953 55669 11004 64780 5890 64145 64147 9732 57572 10603 5889 140628 2621 1017 2207 7094 25942 9564 3675 1398 8968 928 1793 83700 3687 139322 3683 5879 965 967 5770 4680 387 3481 4843 5768 3674 3676 3678 1088 6647 3066 3065 54518 653604 4282 10411 27040 5055 1072 302 6678 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex 5518 1452 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels 10021 348980 57657 610 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 5928 3417 5925 23657 7422 475 1670 472 1870 50507 8649 84701 6117 6119 6118 7099 10542 2137 2135 4194 8550 23643 389541 51360 538 28956 4193 57521 7322 6009 10498 5052 25994 7709 5608 10524 405 406 7001 93661 9861 5682 2353 5683 5684 5685 5686 55860 5717 5718 5719 55004 11047 51164 10213 5713 5714 1026 7979 84516 2475 1386 5690 5594 10671 5691 5595 5692 2168 5693 58528 5694 5695 5706 5707 5708 5709 4851 5687 5688 5689 4683 5034 5700 10808 5701 4363 338 27000 26353 5702 259217 5704 8720 1410 5705 116835 890 7266 8900 51182 573 3337 6767 51501 57805 341947 9531 22824 8714 6782 26277 25913 3310 65057 91582 3305 5580 7013 11340 9529 7014 54386 8570 10049 3308 9261 23404 54512 3312 7514 7184 5393 8878 23016 10111 8021 4361 5073 140801 51010 167227 64223 51013 207 118460 545 22894 440 1432 56915 57761 672 3552 3304 5226 5600 467 64121 83667 4512 3329 4513 4514 9978 10670 153129 7290 10370 10325 57634 81501 153222 90993 64764 148327 84699 10488 6122 6124 6123 6125 6130 6133 6132 6135 8452 6134 6137 6136 23135 51121 6128 6129 644 645 6142 6141 6144 113235 6143 6146 6147 23165 6139 6138 6152 6155 9631 6154 7175 6157 6156 6159 6158 6164 6166 6165 6168 6167 6169 23521 6160 6161 6175 6176 6171 6170 8091 7323 348995 6173 493869 9883 10897 140809 57122 30001 64061 10641 55746 6921 55364 1032 6181 1031 2114 79594 6923 22809 1728 1054 56005 2134 23279 6734 79023 6745 112399 112398 10762 23334 3490 3009 3008 6396 3007 3006 54205 3005 129401 55738 3024 440275 126374 4927 23523 3159 9812 652968 79726 213 8994 3068 115209 54468 23043 4189 7466 84219 96459 50488 5903 9448 154743 9688 23225 9681 11015 8131 27244 55062 3297 55706 144577 3281 27230 23636 2880 9972 2878 27429 11097 23511 79094 2882 7086 29855 8086 201163 53371 468 79400 8480 55466 7353 79902 4800 81502 4801 3301 729438 1388 4802 10985 55666 10954 55033 10130 1649 55846 4217 2056 5241 25842 6256 6649 10113 5465 64344 4199 23677 2099 6095 3397 367 2077 81929 2908 22926 318 2081 10106 1327 4306 23373 9451 10424 10587 9709 57600 2289 55662 9973 54583 118 7157 3309 10072 1329 23645 1340 10061 9797 1460 1337 257202 116138 1339 9570 11133 9588 1459 10935 1351 26043 1457 1350 9361 27102 58477 1663 1349 1200 1347 1346 1345 9429 5526 139285 4862 3306 11331 30968 10730 3336 2288 8204 10963 7296 100137049 116832 7295 6464 4688 4899 4689 613227 5611 4609 51143 3091 79728 4343 192669 23112 27327 26523 2877 192670 57690 2876 2887 200916 9045 1950 155066 9114 8454 8655 6233 7321 4790 1781 25906 3320 11065 8697 7324 10393 1778 29945 29882 523 996 27287 525 84962 526 51343 527 51529 528 8881 64682 529 5970 3163 140735 7316 27338 3162 119504 1051 246184 1029 3569 127124 6667 7531 51434 51382 51433 6230 23410 6232 533 6231 534 6234 6235 6227 6229 6228 10540 6818 245972 245973 8945 125965 7311 9550 80205 7314 3313 6500 81631 8992 90423 10121 10312 11258 9296 596 598 6774 114548 9695 84447 10728 3326 3456 11224 84335 25873 6188 6187 6189 4697 768 2931 5563 51266 4209 64784 200186 10743 9349 6191 6888 6193 6192 6194 25828 3921 2729 9377 2730 10000 2197 335 140032 6907 6201 6203 8648 10891 6202 5931 653361 96764 94239 1780 208 23054 1536 1535 6210 51065 7415 6205 6204 6207 1783 6206 6209 6208 6223 6222 6224 54145 7428 6218 6217 10628 6502 8331 8337 8334 8335 8535 37 8341 10013 8342 374 8347 5154 6045 8348 4780 8345 7975 2113 648 8340 6015 1915 23466 9532 9530 1387 1912 1911 8338 10294 80012 57332 84733 2673 85441 85236 8349 1639 6604 9575 9572 2938 8290 22872 2932 2940 811 6347 8453 2033 898 8370 2146 829 9134 79813 4097 343 10499 3043 2950 3013 830 832 6197 6196 6195 3040 4208 255626 5584 3576 5599 5609 3021 6416 5601 7867 5602 5606 3018 3017 1869 3725 3014 7027 1871 2309 79718 6737 7029 9167 5598 8841 474382 2034 10919 1019 815 8970 816 1017 51726 128312 817 7094 818 1027 25942 55766 8726 8968 23411 55620 1965 5753 8894 10525 1021 1968 2539 84181 51606 5469 1030 9820 847 6647 6648 653604 4001 9817 4000 3484 9612 30827 9611 4736 23512 64839 571 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants 2322 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen 2812 7450 11093 2815 3672 2814 2811 2207 4067 2534 3688 3673 8515 51206 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection 6431 5356 10250 3188 5295 3184 51362 199746 9716 3192 3191 6427 3190 6426 8896 6429 4061 6428 6238 10189 10084 9789 8683 8449 9775 23350 9295 9343 10921 56259 11338 22924 80349 10945 7307 10946 3178 10949 4670 3187 10907 10914 6233 5725 1191 9382 3320 27339 83443 3183 7316 7099 929 7431 8974 253260 23643 79869 283208 8737 57521 5033 4067 57506 4792 4751 9641 8678 5289 1499 7311 7314 81631 2475 6383 10082 6385 22863 6382 58505 821 5034 79109 100128731 221914 9672 2239 1616 3326 55615 26762 3312 7514 5045 6185 4793 2262 1981 64223 6184 1994 26986 746 54464 3304 2817 1603 6632 5824 1479 1478 1477 6628 1974 1973 57794 1977 8106 317649 9685 6634 6633 11100 2719 6636 10262 6635 90701 3339 3921 6637 10236 84061 5593 6773 23524 115004 57703 689 7991 340061 6886 201595 4318 3703 23020 85313 7082 9879 335 9410 3838 1655 11051 9416 1650 10181 317772 51585 23478 30849 85235 5093 5094 6141 51593 54623 22916 84844 1982 1993 4686 8175 375790 10015 8189 51503 4153 23601 5430 9076 5431 221613 7415 55696 5432 5433 92815 712 8969 716 721 722 440689 725 4666 4691 56949 8331 5546 8337 8334 8335 2963 2962 7301 29959 10313 5436 54344 51639 5438 23168 8341 8342 8347 5439 8348 51645 8345 8340 8672 9532 7317 10533 10291 8338 10294 51692 3836 2923 10283 25777 8241 51234 10286 7251 10285 55763 8729 85236 8349 27316 1660 60559 1654 3839 1665 84991 3840 3841 2521 81608 79577 10898 7353 55339 123169 4904 10421 55236 4836 55666 811 7341 285755 8370 22826 22827 6993 54883 64135 7329 3013 11325 55749 4360 23451 64225 255626 54431 7318 10450 3309 5440 7706 5441 1175 10461 160 161 163 2147 11314 3018 3017 54463 3069 53938 22938 5434 28972 5435 23283 5437 23352 3837 440400 24148 7448 9646 53981 5627 51340 57461 57551 27238 29894 815 8970 2621 816 51726 128312 51729 817 818 402569 80273 30835 8968 10992 10525 10527 945 10523 10978 3181 3185 2194 988 6627 6629 22937 653604 220988 23450 8813 6638 9039 8818 10594 91937 5611 550 10965 9785 79876 6430 558 6432 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN 673 4803 4914 6014 6016 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress 2767 5520 59345 5296 79109 5290 5291 4323 2782 5293 2534 2776 3551 5586 55615 10681 1147 25 8517 133 3791 5175 9780 3685 4846 7414 3690 24145 64223 207 59341 4790 808 5519 84290 10413 5515 2324 824 5577 826 5970 1003 111 112 113 114 115 5747 7094 253260 2793 2792 2791 2790 2788 2787 2786 196883 2785 2784 4792 10266 5573 2783 5575 51764 5576 5770 2778 107 108 5567 6772 109 5568 10203 9641 5518 3678 1499 94235 2475 5029 55970 5566 3688 5170 302 54331 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology 2874 5929 6907 814 25942 3065 9070 808 84661 79718 11091 5566 9612 9611 8841 8085 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX 2159 2158 2157 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism 6128 6129 6201 6142 6203 6202 6141 6144 6143 6146 6147 11185 6139 6138 6152 6155 6301 6154 6210 79048 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 6165 6206 7965 6209 6168 6208 6223 6167 6222 5917 9521 6169 6224 23521 6160 6161 3735 6233 6218 6217 6175 6176 6171 6170 9061 6173 9060 4141 4143 6181 6230 6232 6231 3176 6234 6235 875 6227 6229 6228 9255 7311 27232 60678 51520 1615 51540 4837 11224 3376 25873 6188 140801 6187 6189 51091 9349 191 6191 6193 1491 6192 6194 2058 22928 5859 3921 118672 7296 6122 6124 6123 116832 6125 6130 6133 6132 6135 6134 2197 6137 6136 51121 140032 4736 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) 56659 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS 4893 6654 4915 3265 627 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages 2247 7039 3913 10319 3910 5617 1950 374 3914 3458 3915 2335 3918 3909 1435 2255 7448 2252 284217 3911 3912 2249 3908 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli 5296 5290 5291 5293 5586 25 3791 24145 59341 4790 808 5027 781 782 2324 5577 5970 1003 253260 2793 2792 8912 2791 2790 2788 2787 2786 2785 2784 4792 10266 2783 51764 10203 9641 5518 94235 59284 1499 2475 55970 5566 5170 2697 54331 2767 5520 59345 79109 4323 2782 2534 2776 3551 55615 10681 1147 8517 133 5175 9780 3685 4846 7414 64223 3690 207 84290 5519 10413 5515 824 826 111 112 113 114 115 5747 783 7094 784 196883 5573 5575 6696 5576 3339 5770 2778 107 108 5567 6772 109 5568 3678 5029 302 3688 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching 5111 10714 5424 57804 23649 5981 5422 5984 5985 5557 5558 5425 5982 5983 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling 7316 10133 8772 7186 84888 25999 90268 841 56928 8737 8717 7322 3551 29110 9099 7332 9261 7185 1147 8517 8408 9641 10273 27005 220213 7311 330 7314 331 10616 142678 6233 56957 7321 7132 7375 55072 81858 10399 1540 9825 8887 7128 7323 329 7124 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 5436 4331 5438 5439 902 404672 22916 2071 7469 2068 4686 6829 5430 5431 6827 5432 5440 5433 9150 5441 2966 51497 2965 25920 5434 5435 5437 7936 2968 2967 1022 2963 2962 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion 5058 5062 8829 5063 55558 91584 5361 3320 2534 10371 1072 3326 3984 2242 5879 5362 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly 8341 11335 8342 8970 8347 8370 8348 128312 8345 22850 10951 94239 8340 23394 55766 8968 3013 8338 1108 255626 85236 8349 3018 3017 54145 3014 653604 8331 8337 8334 8335 474382 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 7316 51072 3084 2549 5295 1729 6714 2069 5290 685 208 10718 2534 5580 5753 1839 7525 387 145957 5578 10273 1950 5335 2064 1956 6464 2886 7311 7314 5782 10193 207 6233 3320 10000 5581 4893 6654 8065 9101 4145 3265 26469 9542 11140 55914 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 192669 23112 27327 26523 27161 192670 57690 4343 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface 51248 6556 538 475 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 5959 5949 51109 6010 9227 3292 285440 50700 7276 10170 8630 24 4647 157506 5947 145226 6017 8608 121214 64220 6121 5950 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 28227 5518 5925 1869 23649 5422 7027 5519 5557 5558 5515 7029 5516 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes 983 1460 64151 9133 10592 9918 23397 10051 1459 1457 891 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions 3813 22914 9402 3937 7305 5295 3822 3824 5336 5296 54209 54210 5290 5291 567 6850 3133 2534 5879 10451 284266 23601 7410 5335 124599 342510 100132285 10326 3107 3106 4893 100049587 6654 695 3265 3809 3932 9436 3810 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 5436 6908 4331 5438 5439 902 129685 6872 404672 6874 2071 6873 138474 2068 6881 6880 5430 6883 5431 6882 5432 5440 8148 5433 5441 6884 2966 2965 51616 6875 6878 83860 5434 6877 54457 5435 5437 2959 2958 6879 2968 2957 2967 1022 2963 2962 2961 2960 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism 23411 10891 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 10055 6612 25950 10054 7341 7329 6613 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling 3320 2064 11140 55914 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway 3718 80824 5295 5296 10818 5290 5291 3667 1739 3845 1849 1848 1852 9986 1846 1850 81926 5156 1950 377630 58489 51104 2064 1956 8036 2251 25759 6233 5900 8826 8649 7316 3569 28956 5500 4296 6712 5588 115727 10125 9861 5682 5683 7039 5684 5685 5686 5717 5518 5718 5719 7311 7314 11047 10213 5713 5714 7979 983 673 5906 5690 5594 5691 5595 5692 5604 5501 5774 5605 5693 6654 5694 2254 5695 8074 5706 2249 5707 2246 5894 10817 5708 8823 5709 8817 26281 23463 5687 598 5688 5689 5700 5701 5702 5704 5705 2534 5155 2323 8682 5159 221002 5863 9693 2322 54756 84292 57139 2264 7529 9965 152831 51114 255324 3562 10048 3559 3558 5781 10434 2342 51125 9978 2339 2335 7297 408 10256 5593 4140 88 1439 1438 5037 1742 8452 4893 9462 4763 1741 64926 3716 84078 8660 1740 8831 3265 399473 10156 161742 200734 22821 153090 8437 5921 5922 4747 409 2906 2902 57554 23179 283455 5923 6300 808 11221 1445 5924 5147 3082 5908 4233 374 3567 9048 369 64096 4902 4684 2675 5623 2248 2255 2252 27006 2904 402 3815 2676 6708 7450 6710 22866 22808 5786 1437 3717 53358 57731 2266 7414 3690 2243 5519 51332 5525 8315 5515 6709 25780 5526 5516 5527 5536 5528 5529 9542 2244 3084 5245 6711 815 5747 816 6714 2069 817 7094 818 685 3563 152559 10718 3560 5778 1844 1843 3568 1839 1847 2668 145957 2247 3570 3674 5979 7010 6464 284 54518 2674 3561 8844 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 3417 79728 208 23657 7415 1950 8454 6233 4790 6502 140809 5970 7316 3162 1029 374 6667 79594 5154 1728 4780 7975 5052 1387 9861 5682 5683 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 81631 10213 5713 5714 7979 1026 27244 5690 5691 5692 5693 5694 5695 2938 7086 5706 468 5707 2932 7353 5708 5709 596 4851 5687 55666 2940 598 5688 5689 6347 2033 5700 5701 4363 5702 5704 5705 6649 4199 4097 8714 5580 9451 5584 10072 8878 10061 1460 1459 26043 207 1457 5563 6737 672 9429 5226 139285 6888 83667 9978 2539 84181 7296 2729 7295 2730 9817 10000 8452 64839 4609 571 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells 9371 51143 9493 829 114876 1780 81930 84643 830 832 3796 3797 3831 3798 3832 3799 1509 1783 1508 3835 1514 285643 1513 8655 1781 1515 56992 1778 89953 1520 11004 5476 140735 6712 11127 3112 10540 3111 3109 3108 1075 93661 7879 55860 1512 1510 3123 3122 24137 1519 3120 1062 8722 64837 3119 1639 26153 3118 10120 51164 3117 3115 3113 147700 83547 84516 10437 10671 3127 22920 3126 3125 10121 11258 29127 10112 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 4821 4760 3642 50674 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 9575 1387 4862 5187 8864 8863 4297 1454 1453 406 1408 1407 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression 51082 10849 6908 4331 30834 8370 902 404672 94239 3013 221830 8819 7343 8932 255626 5440 23309 5441 3021 2966 9533 2965 3018 3017 54145 3014 5434 5435 11176 5437 8331 2968 8337 2967 8334 9014 8335 1022 9015 9013 474382 8341 8342 84172 8970 8347 8348 128312 8345 8467 25942 2071 8340 79685 55766 2068 29115 8968 8338 1789 1786 25885 79595 85236 8349 3066 3065 653604 51742 10284 64425 64426 7270 79101 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 5058 9497 157769 6510 9528 55075 114885 253959 55717 56924 57144 9341 396 397 398 399 1629 6093 10376 10298 3728 7415 2631 7879 857 9475 5062 55004 55968 81839 4548 2040 1445 1627 7535 7037 3932 GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation 25925 7852 7022 7021 5080 7020 3170 6469 5453 6934 5015 6656 7546 7004 4087 4088 4089 1387 89780 5460 5077 7545 4487 9861 5081 5682 83439 5683 6657 1749 5684 4602 5685 8463 5686 28514 5717 3516 51592 5718 5719 1499 84667 11047 10213 5713 5714 7979 3955 343930 5690 5691 5692 134701 5693 5694 5695 2043 5706 2249 5707 145873 5708 5709 51176 4851 5687 5688 5689 6911 6932 2033 5700 5701 10683 5702 5704 5705 8928 999 8320 6862 145258 387332 9241 79923 83881 84441 9794 2627 344022 2626 55534 6615 2294 22938 9839 10413 3549 10046 2253 8850 130497 2296 3169 2303 652 2247 3975 5076 64321 2260 2648 7849 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b 7841 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling 2572 2571 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport 23428 92745 57153 6511 6533 6510 206358 84889 6509 55089 117247 246213 340024 10991 6506 7781 51000 6505 6532 23516 54716 7780 6507 64116 80736 29986 9056 25800 9057 57181 8501 153201 27173 6541 29985 81539 283375 7922 123096 23657 7779 55117 115584 56301 861 114134 1811 11254 6526 6512 11136 6540 6519 140679 124935 54407 6529 51248 10599 10861 6556 26291 57468 6560 10723 6558 51296 6564 121260 53919 6248 6576 28231 11309 6567 284111 9058 9356 159963 64849 65010 6520 115111 115019 6513 6515 6514 8402 154091 155184 144195 66035 55974 6527 125206 160728 6561 55532 6574 6568 254428 91749 11182 85414 84102 200010 26266 1317 83733 6528 10568 6569 142680 8884 6582 6580 57084 57030 6536 345274 60482 6534 6539 6538 1468 6548 1836 79751 6584 6583 682 6579 9194 64924 133418 123041 169026 9843 5002 10559 376497 9497 6517 23169 80024 57419 25769 9498 23382 83697 6522 57835 6508 57282 808 6543 6546 55630 6547 6717 64078 347734 23443 292 2030 293 23568 55343 389812 10999 3933 1497 286256 9990 7355 28965 222962 3177 9197 120103 9153 8671 9154 84912 55315 347 5172 9152 402 81031 84679 6550 9187 6553 389015 6549 23315 10479 285195 29988 6521 6531 6530 11046 6524 6523 30061 353189 6566 6557 6559 6575 23446 126969 6578 291 283652 9376 6581 204962 116085 56606 26503 1356 4891 9123 284129 8140 23539 6563 8170 55244 115286 28234 146802 85413 55356 551 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling 10627 5058 28964 5921 1212 5664 5663 5063 2045 2044 2042 2041 2051 2050 2049 2048 2047 2902 2046 2534 55851 83464 64283 10451 7525 4628 4629 8218 25791 7410 1175 160 161 79784 163 4627 10109 1213 1211 1759 23385 1943 51107 4637 1942 6453 71 1949 8997 10398 1948 8874 3984 1947 6386 3985 1946 103910 1945 1944 10552 284656 5747 10093 10092 4067 10095 8976 10094 60 10097 5879 10096 6093 2904 7074 387 9475 5062 102 4313 998 6383 4318 1969 1072 2043 3265 285220 8440 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 21 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation 7157 7316 10919 26013 4194 56950 91875 2033 11200 7311 133383 7314 79813 4193 472 6233 10419 133746 387893 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 898 1017 5925 9134 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells 3958 861 865 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins 5928 23478 5931 5925 4613 94239 4343 192669 5589 23112 27327 26523 27161 192670 57690 9789 3728 23193 54145 7020 6233 27085 1500 3170 79872 10399 2060 8331 117581 7750 8337 8334 8335 7316 8341 8342 6667 8347 8348 8345 4193 8340 8338 9743 9861 5682 5683 5684 5685 5686 283106 9314 5046 9159 5717 288 85236 5718 5719 8349 1499 7311 7314 11047 10213 5713 5714 60559 7979 7291 54737 5690 5594 5691 5595 5692 5693 5694 7088 5695 5706 5707 58505 54971 5708 23028 5709 821 5687 5688 5689 5700 5701 60436 8370 5702 2146 5704 5705 100128731 999 23396 3013 6591 11171 255626 1508 1495 5045 3021 1514 1460 6185 7414 116092 3018 1785 1459 94234 3017 6615 5315 6184 1457 3014 10009 6935 28972 93986 55810 687 9839 348262 746 1520 387893 8289 1603 474382 7841 6929 8970 6714 128312 1488 1487 55766 8726 8968 6938 23411 7764 90701 29954 10585 7490 3066 3065 653604 3703 6597 1650 23512 4609 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA 55746 23279 79023 10762 23165 6396 129401 9631 7175 4927 7514 5905 8021 1104 5901 5902 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 57122 8086 53371 8480 79902 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) 10682 3930 50814 7108 1595 6307 51478 6309 1718 1717 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 5928 10919 11335 23269 6045 5931 2146 84108 8317 79813 648 6015 1111 8726 7703 1911 80012 10138 23468 23429 4149 1869 7027 5888 672 5932 83746 6241 7029 317 8409 80314 1876 23512 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling 5335 7220 7222 7224 7223 57113 5306 1630 7225 9423 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 5687 5688 5689 5700 5701 5702 5704 5705 993 79858 11200 8454 6233 1432 5600 1454 7316 1452 9978 23291 1111 9861 5682 5683 1263 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 2932 5708 5709 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations 55624 10585 1605 29954 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development 2874 808 6907 79718 814 5566 9612 25942 9611 8841 3065 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm 4851 5687 5688 5689 6911 2033 5700 5701 10683 5702 5704 5705 6862 9241 84441 9794 55534 22938 10046 8850 1387 89780 9861 652 5682 5683 5684 5685 5686 28514 5717 3516 5718 5719 2260 1499 84667 11047 10213 5713 5714 7979 3955 343930 5690 5691 5692 2648 134701 5693 5694 5695 2043 5706 5707 145873 5708 5709 51176 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 5929 4148 10445 23314 4057 200845 4069 80341 6406 9861 5682 5683 5684 7039 5685 5686 5717 5718 5719 1499 114907 11047 10213 5713 5714 7057 7979 5690 5691 5692 5693 5694 83746 5695 5706 5707 5708 5709 5687 5688 5689 5700 5701 5702 5704 5705 5096 3312 8021 79823 1981 26986 4878 3329 9978 7703 2218 10329 10559 9486 79147 11041 9215 113829 55624 729920 1605 120071 8452 84078 718 23165 9631 7175 6881 4287 7323 348995 9883 57122 94115 55746 6921 6923 23279 79023 4086 4087 10762 4088 4089 6396 142 129401 64750 4092 4927 7518 9314 5905 51616 5903 9688 23225 55706 23636 9972 11097 23511 8086 53371 8480 79902 1462 411 2720 59348 9246 64135 23586 8517 7706 2155 2153 2147 2266 2243 3053 8312 324 2159 2158 2157 8858 5624 5627 139285 462 91689 3827 51156 6687 5610 10939 10210 23203 145173 57188 221154 2591 143662 10417 118430 5329 10730 10418 2590 170689 171019 54437 9037 4582 5199 4583 4584 7058 4585 4586 2625 200958 157869 29954 727897 652 29071 140766 80070 10585 9508 9509 80124 10071 10318 94025 79931 339366 161725 221981 55593 140453 78990 79875 81794 55432 79589 4588 55901 55611 4589 54764 81792 283463 9719 56913 394263 11173 11174 80731 54507 92949 170691 5611 4609 3091 79728 7040 7022 7021 7321 11065 7324 154 5970 27338 1029 3569 6934 6230 6232 6231 6234 6235 6227 6229 8767 6228 57506 6483 6482 9871 6484 7334 6487 9632 6480 10427 256435 27090 9868 9641 11282 8678 444 6383 59272 58505 821 114548 2589 51201 100128731 10610 136 346562 89122 10392 9097 6288 11274 6185 6188 6187 6189 6184 3105 11253 746 1603 5179 7841 8775 6191 6193 6192 10618 7284 6194 51128 84282 6885 408 2719 5878 3921 2804 7187 7189 84061 55741 11320 653509 7991 6440 729238 4245 6439 4124 1439 1438 10802 201595 10484 3703 2197 140032 1154 1655 1650 4247 2688 147111 4249 10454 8835 5617 6441 6201 6203 6202 64127 409 25834 567 6727 5589 57719 6210 51065 7415 6205 6204 64326 6207 6206 6209 6208 326624 6223 6222 6224 23193 2530 7428 6218 6217 808 154881 908 7320 113457 6950 7203 6478 2793 2792 6477 7280 2791 283807 2790 26272 6905 51088 2788 9616 2787 2786 7317 83752 2785 7319 2784 26234 3093 2783 7332 51764 10693 6468 7336 10376 150726 10574 10694 118424 6902 10576 55336 2629 7327 10575 80086 7326 26190 6904 7328 26270 6903 9630 94235 54926 51807 6000 65264 22803 8787 10381 9545 93611 127247 7411 401036 8786 79791 55294 112714 55135 55970 51665 6059 402 9628 51666 84790 10471 5201 5202 63891 6499 5082 142686 84617 11328 142685 55236 54331 51676 2767 10238 142689 59345 10517 26330 8453 898 1155 2519 347733 84261 80204 2769 9134 57542 7278 22948 63971 26985 2782 26224 79861 23014 81027 5071 54461 2776 10528 5203 25793 5204 10681 11275 8877 10564 64410 222235 54850 5870 140456 6400 140458 2683 140459 90135 25898 146330 140460 140461 140462 54620 401258 10959 115290 7704 55958 8139 10402 390594 55284 84961 8924 2034 122769 53916 9021 53917 1315 55175 27252 51130 26046 9903 2215 92369 126433 26259 201456 80028 144699 899 84861 92912 387 10477 26268 90293 10055 5768 10054 84727 92591 26263 8875 26267 8876 53339 285231 89890 9820 26235 26118 79176 26232 84085 4008 9817 51725 9039 26249 8065 140739 9040 79754 84541 80176 23194 136371 10324 197 51816 993 2801 2890 4905 11338 9986 135 377630 23438 57176 25973 55157 80222 10667 79731 79587 51067 55699 124454 23395 57038 4644 10352 92935 54938 57505 11019 387787 27247 51601 349667 94005 5067 8733 146183 116372 7186 2822 84720 54872 53942 128869 152330 284098 353091 51604 8737 4062 5277 7322 137797 5279 997 390243 93183 8581 84628 4792 10942 55650 26085 171169 80235 8915 51299 249 7007 54965 84992 10026 4978 360226 147719 5283 9487 9488 135228 23627 161357 130576 8434 1043 1087 7046 58530 7048 146760 251 5281 22854 80740 503542 646627 51227 10232 419 349633 8000 8074 4241 4045 7512 80328 7070 83639 23556 10568 257194 6569 266727 27076 5034 420 1368 80055 338 1048 54742 284348 991 6975 890 50863 8900 123904 154064 2813 81849 6746 6748 6747 27089 6731 6730 6729 3630 6726 6728 23471 4967 8878 84749 84164 10973 140801 90850 22915 55568 8975 79812 81847 11227 11226 23252 374378 5987 8658 51809 4508 9245 80351 168391 4509 63917 51146 51301 50614 148789 27068 23275 8693 129080 140838 442117 374907 84620 55907 64409 10632 146664 55808 6489 84752 140687 10020 54187 84750 84197 80896 114805 7903 4519 129807 2650 192134 4512 117248 4513 146712 4514 26290 170384 57452 79623 2350 1975 84892 10164 1974 1973 1983 1977 5859 5862 4540 4541 4535 9669 5867 53918 4536 5868 4537 4538 622 27034 1066 51121 6770 5443 4597 1081 29880 256281 6301 5464 23521 5080 207063 84920 144245 197258 7264 8790 29926 29925 3375 2762 5372 57171 282969 54516 9617 84340 4539 4141 92399 5476 22796 347517 84342 91949 23265 25839 683 27314 51272 378 60412 83548 57511 54536 9527 9609 10466 10640 8542 11336 149371 10678 211 213 217 219 55763 8729 55770 8766 54471 91574 123263 4528 219402 51250 115416 7353 51520 22980 9147 23008 55139 55666 5018 4052 5019 4191 4738 51377 55851 83464 11167 51552 347527 91851 10272 84002 7252 9958 51107 3625 3624 3623 90268 7276 153642 26503 9126 8204 10735 10274 8243 5885 7295 8451 8533 340075 8450 133686 64708 125476 10987 10980 93973 9100 29844 54891 79913 50813 54617 10920 2864 1642 283899 54995 83444 4976 5886 197257 4798 5887 29928 51142 5832 7508 1891 26519 26520 8192 10845 10440 255738 26958 9045 23708 51014 339122 5917 23423 3670 372 23032 2107 381 51504 3735 27430 9276 2935 1978 8662 11316 8663 8661 8666 8667 22818 8664 8665 1314 27335 3646 54732 51226 51386 7458 8668 8669 22820 10480 1964 11014 151194 22944 79091 79642 399818 254013 221143 79644 196483 79609 6804 143471 389362 56984 51371 3313 80227 5710 10197 122706 5711 8624 1294 5715 5716 84262 9491 23198 25862 100287513 100287238 100287478 401447 9736 645836 728386 51651 100287178 6844 29761 5864 57646 84101 100287327 100287205 9695 4200 6048 100287441 645402 91445 100288520 80267 10206 8724 56886 392188 219333 10956 267 100287144 84447 10868 10869 7844 10299 23770 55757 91833 11236 84196 9960 51009 8078 728419 100287404 100287364 4695 55031 23358 83844 57695 84132 10600 11224 3376 25873 813 25870 29106 90865 6694 334 2335 2058 1487 5869 90701 85365 10331 79947 79087 10195 335 336 337 23478 199857 54623 348 375056 4253 11070 6472 79053 5162 5163 9521 721 25809 23287 254173 25941 374969 60509 79739 54839 158135 5160 284076 22846 375 9654 164395 377 123624 26140 23170 23093 83887 10342 79841 91978 84276 150465 79805 340351 84871 54344 36 38 23168 384 21 9526 50 2923 116150 79139 7385 1639 56052 60559 22872 79796 811 22845 1615 4351 1629 1632 91869 28972 9646 93010 4706 2525 2621 1798 2677 4719 1356 4712 440138 4722 4723 8813 8818 4731 4736 3419 3418 3190 5373 79868 4061 29929 9789 126119 4758 92552 4759 9929 80349 10945 57599 2109 9382 3416 64432 65003 64951 65005 65008 338328 28977 90480 114803 10617 51081 23172 6150 55168 57559 64949 28973 65080 51642 54998 10573 11222 116519 128308 51649 9553 64960 63875 64963 64965 64968 55052 55173 64969 51373 26284 51650 51253 60488 51258 219927 29074 10102 56945 28998 64975 64976 79590 410 64979 64978 412 23107 28957 64928 414 7818 415 57129 51263 8703 29088 416 8704 51021 54534 8702 51023 51264 7369 51069 79694 84545 85476 10476 432 433 78988 122704 65993 64981 10240 64983 3396 26589 8720 63931 6182 3033 54460 6183 51073 118487 116540 740 3028 124995 54148 116541 55037 29093 9801 51116 10884 54948 51318 3485 3483 51246 54757 8404 3491 3489 7184 3488 3487 64856 10117 3816 1114 258 7857 5954 92305 56955 6596 3270 9781 56852 265 285362 401138 51322 5069 5591 51280 5195 56975 5192 5193 60676 5194 3956 5828 4924 51255 8614 257218 174 54972 55829 3698 9810 84141 220441 327 9210 11098 54587 5222 1755 7416 221395 29080 643834 9476 29995 643847 6122 6124 6123 6125 3098 115827 64284 30815 57799 5865 376267 6130 84932 6133 8934 6132 51715 57403 6135 401409 10966 55647 25837 6134 115273 6137 142684 6136 83871 57111 8073 4482 5110 498 253827 51734 6128 6129 6142 6141 6144 6143 6146 6147 6139 6138 79090 6152 6155 6154 6157 6156 6159 6158 23163 51762 23682 6164 6166 10890 6165 6168 6167 6169 9230 6160 6161 27095 6175 9363 81876 6176 6171 6170 6173 338382 201475 51399 1122 7109 6181 6399 5861 11021 51560 5872 5873 11031 126003 58485 51693 1738 1737 116442 26088 122553 23011 1743 10981 10825 22931 23062 83696 5874 54734 9255 83452 128637 92259 4286 2641 3972 1327 2653 63967 1329 2934 5728 124872 2230 29104 4311 116832 2235 5029 10965 506 509 2271 2922 8801 200916 522 7965 539 338557 3158 5122 2695 1045 3952 139760 8869 1803 288 51079 79697 89978 1819 83475 64122 1984 55854 51611 4733 65094 91433 23463 79672 79831 92715 51389 285381 120526 100137047 55239 56648 1725 1802 1801 1361 29906 150 152 966 8460 1604 8459 9334 9331 183 9349 5423 2028 3479 1395 64924 79369 57393 2999 3800 25924 619373 7941 1363 290 1360 83729 1359 2488 10159 1636 5972 9377 3626 169026 22901 1522 7349 5126 56605 9189 197370 493861 9994 3090 115426 7690 2746 79677 56160 54780 668 10521 6670 6672 205564 51602 286053 25950 23137 11315 4152 59343 6294 165918 7153 7155 7158 5893 7150 9761 64772 55768 51035 1431 4791 1000 351 6502 7453 16 8565 9101 3035 2193 833 6897 4677 10056 7407 2617 374 4780 1938 1937 1936 1933 1917 1915 29089 829 830 832 3798 3799 2627 2626 56652 7019 6742 8893 1965 8894 8891 8892 1968 8890 1967 9146 3481 7879 55176 5721 29927 5696 5720 23480 5698 5699 9554 10952 6117 7425 4194 1121 4193 6712 4869 9656 9099 7486 1075 93661 55860 1512 27166 51164 1026 84516 10671 5875 5876 7417 9212 7419 9804 3486 1616 641 51499 114785 55252 55777 3607 8314 7345 7347 221937 123228 171023 7874 1643 672 5111 28996 332 10670 5371 580 3622 286 260334 10196 347688 57134 4121 10905 93624 317772 85235 23326 23210 25879 84864 221613 8295 92815 8969 8607 440689 6314 221656 292 293 55343 79594 6734 6745 3490 55738 3895 115209 10970 7466 11015 56667 27230 27429 11093 7341 10130 7376 7068 5241 6256 7421 5465 10113 8554 64344 10652 2099 3998 7181 6095 367 4929 6612 2908 51588 9759 5468 7329 6613 4306 5914 10401 2516 7157 10072 1460 9570 590 1459 26043 1457 9361 58477 6811 57104 6709 29086 51720 84142 9577 79184 6711 248 55143 43 10254 51138 1080 51143 10537 55208 28952 23142 26094 54939 9655 23038 140825 56910 10489 23369 54951 23363 54165 9306 149951 1161 80344 55827 23113 55832 84259 56929 79016 51122 54876 50717 83987 150684 8816 90864 170622 10116 6790 29099 79269 8454 51397 8655 55884 55527 23412 6233 56995 1781 28991 80067 123879 8883 122416 51514 1778 3183 1453 140735 7316 9738 10383 10382 23291 1069 7846 10540 4218 354 8945 7277 7311 7314 6500 983 10121 5566 11258 6774 1215 3915 3912 9510 84364 51209 9507 1509 23256 5045 7045 1511 9027 793 796 3817 6622 10098 54959 1471 325 23385 9627 9445 6653 23621 340348 3015 7076 4240 81619 23555 9318 170690 170692 5340 8239 6696 55288 3339 56999 56254 11096 11095 8027 102 4312 57591 4313 26286 9367 8648 10891 5931 7018 1107 1780 2873 1783 29843 54145 3619 8331 8337 8334 8335 8535 51564 6304 8341 8342 8347 6045 8348 8345 648 8340 7528 6015 1912 1387 1911 60 8338 80012 57332 5265 8473 8774 84733 23243 22870 2348 64841 10175 55577 23468 10972 5537 2673 9117 6675 5973 11196 64689 51005 5238 55291 85236 9945 254263 27005 25956 8349 55014 10155 330 81562 63908 8615 149111 9919 56957 90411 7375 10282 26984 79748 1540 89866 10960 7128 329 64426 7270 79577 123169 6708 8313 86 6710 2033 8370 10499 1435 9112 64377 338596 4221 51046 4248 3013 4122 8128 2517 6996 255626 79155 3021 57731 3018 3017 3014 287 10474 51332 8841 474382 8970 8850 128312 25942 2200 8968 3054 1789 1788 1786 3913 3371 3066 3065 1758 653604 4303 2648 11091 3484 9612 632 23512 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 650 10891 4488 5925 23314 3280 208 595 861 7525 25925 865 25 579 2101 8454 10432 25937 6233 6502 117581 7316 4094 10013 59269 11059 4086 4089 23493 4091 9861 5682 891 23462 5683 1749 5684 5685 5686 5717 10273 5718 5719 9464 7311 7314 11047 6500 8493 10213 5713 5714 7979 1026 7291 983 9358 5690 5594 5691 5595 5692 5693 221044 5694 5695 5706 5707 2932 5708 5709 1750 5687 5688 5689 5700 3958 5701 5702 5704 5705 57154 121340 2099 367 2908 9759 207 10413 3549 8841 1019 6714 9978 581 6772 2737 3678 4322 2736 133522 1277 6662 10000 632 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress 3417 79728 2877 2876 23657 475 1950 8454 6233 50507 4790 84701 5970 7316 3163 3162 1029 6667 538 10498 5052 7001 9861 5682 5683 5684 8945 125965 5685 5686 5717 5718 5719 7311 80205 7314 11047 6500 81631 10213 5713 5714 1026 7979 5690 5691 5692 2168 5693 5694 5695 5706 5707 5708 5709 596 4851 5687 598 5688 5689 5034 6774 5700 5701 114548 4363 5702 5704 5705 341947 8714 5580 8878 207 4697 5563 672 5226 6888 83667 4512 4513 4514 9978 25828 2729 9377 2730 10000 8452 6907 644 645 8648 653361 96764 23054 208 1536 1535 7415 10628 6502 493869 140809 30001 374 79594 5154 1728 4780 7975 1387 54205 213 85441 6604 27244 2880 2878 2938 2882 7086 468 79400 2932 7353 81502 55666 2940 6347 2033 6256 6649 5465 4199 4097 343 10499 3043 2950 318 1327 9451 10587 3040 9973 5584 10072 1329 1340 10061 1460 1337 257202 1339 9588 1459 10935 1351 26043 1457 1350 1349 79718 1347 1346 1345 6737 9429 9167 139285 8841 25942 55620 5753 2539 84181 7296 5469 7295 847 4688 6647 4689 6648 9817 613227 9612 9611 64839 4609 571 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling 3718 55801 6774 7297 50616 58985 3717 6777 6776 6773 6772 3588 6775 163702 53833 53832 11009 50604 282617 282618 282616 29949 3716 116379 5781 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles 8815 11168 3159 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly 10073 1207 22916 96764 23165 4686 9631 7175 25929 54960 6607 8487 8021 51808 10419 348995 9883 57122 6632 55746 23279 79023 6628 10762 6396 6634 129401 6633 6636 6635 4927 79084 6637 79760 79833 5903 9688 23225 11218 55706 50628 23636 9972 11097 23511 8086 53371 8480 79902 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs 192669 23112 27327 26523 27161 192670 57690 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors 2812 3827 2161 2815 2160 2814 2811 2158 3818 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling 10068 240 8809 27178 3596 8807 3565 3606 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins 170692 11093 145173 57188 10417 10418 170689 171019 54437 9037 5199 7058 9510 157869 56999 11096 9507 140766 80070 11095 9508 9509 339366 221981 79875 81794 55901 81792 7057 9719 11173 11174 80731 54507 92949 170691 23275 170690 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 1616 546 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis 7316 5687 5688 5689 5700 5701 5702 79658 5704 5705 4976 9861 5682 5683 5684 5685 115209 5686 5717 5062 5718 5719 7311 7314 11047 10213 5713 6233 5714 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG 100137049 26279 255189 254531 79888 50487 30814 9926 8399 81579 5320 5321 5322 283748 54675 22925 5319 64600 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter 51082 2972 2971 6908 9328 9329 55814 5440 5441 9533 51728 27297 661 10623 171568 84265 5434 55703 5435 5437 55718 11128 10622 10621 112495 9330 2976 2975 INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion 203859 50636 5045 57101 55129 196527 63982 121601 55107 338440 57719 7113 59272 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network 5294 5295 5296 10818 5290 5291 3667 5293 208 3643 5156 5305 1950 2064 1956 2251 79837 7409 3082 4233 2549 23533 374 2248 2255 2252 27006 4915 8396 627 8394 8395 7039 8503 5518 3654 5594 5595 3815 4916 2254 8074 2249 4908 2246 8823 8817 26281 146850 391 2099 23396 2534 3630 5155 118788 51135 2323 4615 930 5159 6801 23035 940 941 2322 942 2264 23239 117145 207 50852 90865 8870 9965 5519 152831 9173 9846 5525 57761 5515 5526 5516 5527 5528 255324 5529 5781 9542 3084 6714 2069 5880 5728 685 2100 10718 1839 5879 7189 145957 2247 10000 8660 3932 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation 5753 6725 5770 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation 6128 6129 6201 6203 6142 6202 6141 6144 6143 6146 6147 6139 6138 6152 6155 6154 6210 6157 6156 6159 6158 51065 200916 6205 6164 6204 6166 9045 6207 11224 6165 6206 6209 6168 6208 25873 6223 6167 6222 6169 6188 6224 140801 6187 23521 6160 6189 6161 6233 6218 6217 6175 6176 6171 6170 6173 9349 6191 6193 6181 6192 6194 6230 6232 6231 6234 6235 6227 6229 6228 3921 6122 6124 6123 116832 6125 7311 6130 6133 6132 6135 2197 6134 6137 5611 6136 140032 51121 2926 4736 KINESINS%REACTOME%R-HSA-983189.5 Kinesins 9371 221458 9493 547 55083 81930 11127 84643 3796 3797 113220 3831 3798 3832 3799 3833 3834 9585 3835 23046 90990 24137 285643 1062 64837 23095 26153 10749 147700 55605 124602 56992 22920 55614 146909 89953 55582 11004 23303 29127 10112 64147 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 3162 2940 7296 2729 2033 7295 1728 4780 7975 6649 2730 5052 1387 23657 2938 140809 468 84181 571 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum 4851 56983 4853 4854 4855 23509 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R 2549 5295 30849 5296 10818 5290 5291 3667 3480 208 2248 3479 2255 2252 27006 8471 2323 3481 2247 2322 5289 2264 2251 117145 9965 54106 152831 5140 4893 9846 6654 57761 2254 5170 8074 2249 8660 3265 2246 8823 5781 8817 26281 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations 54490 445329 79799 55347 113612 54996 66002 80777 1545 246181 1543 119391 1549 1548 1558 1544 1576 9049 1565 1571 64816 27284 1557 1559 10858 1555 123876 1553 1551 51504 8824 1572 27430 1562 1583 1582 348158 1581 1580 1579 1577 1573 340665 1594 1593 1592 1591 1589 1588 1585 1584 874 64174 1595 54578 54577 54576 54575 405 6818 6817 54579 6819 57412 126410 4051 6822 55748 124 125 126 127 128 54928 130 131 1800 10728 10720 3326 56603 26873 64757 10380 8460 9 8459 2328 2327 2326 2052 54988 134147 91703 191 196 9915 7172 391365 10941 314 2729 25830 4552 112812 653689 92292 57834 4257 4548 4258 2730 4259 11283 1066 2098 50512 51302 9971 8648 10327 196743 5443 8639 23169 27306 54659 54658 6783 10249 10 13 5447 494143 54905 221357 670 26 4128 4129 4143 4144 389396 7358 1727 7363 7365 7364 7367 7366 6799 7360 216 217 218 219 57491 27233 2939 79094 2938 2937 2944 2941 2940 8529 29785 2949 124975 95 2948 6256 120227 2947 2946 373156 10499 2954 1312 2953 55902 2952 11046 574537 2950 4837 54657 80146 4835 8574 9420 285440 2678 116285 23491 54600 22977 9446 2687 2686 284541 5740 2232 2230 84532 29104 79017 219970 5742 84836 133688 6916 341392 167127 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling 7316 5687 5688 5689 5700 5701 5702 5704 9978 5705 9861 5682 5683 5684 5685 5686 7534 5717 5718 5719 7311 8454 7314 11047 6500 4855 10213 5713 207 6233 5714 7979 5690 5691 5692 5693 5694 5695 10460 5706 5707 5708 5709 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC 204962 57153 1103 84879 58488 23175 79888 10390 80736 56910 56994 1120 5130 1119 171586 64900 9468 1460 10809 10400 590 23446 126969 1459 43 9663 1457 162466 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival 59345 3708 3709 57105 2268 3710 917 2771 3055 6850 2770 136 2782 2209 346562 2781 1800 10800 2534 2214 6868 2212 2773 10681 7525 79651 5045 5335 10769 9332 4627 808 2678 1432 5577 2687 111 112 113 114 115 3569 5336 5613 2793 2792 2791 2790 2788 2787 2786 4067 196883 64174 2785 2784 5573 2783 5575 51764 5576 2778 107 108 5567 10768 109 5568 94235 55970 5566 3586 54331 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta 3665 3442 3441 3440 2033 3439 5094 26007 5300 54476 3452 10010 3451 9246 64135 3449 3448 3551 29110 23586 3326 3446 51191 3445 84166 3444 1147 3443 4214 89122 8517 9636 7318 79671 3456 3146 7706 6285 6288 6283 4791 4793 28512 6233 177 7321 351 4790 28511 3320 7323 5970 7316 8772 7186 84282 83737 841 8737 7322 1387 57506 4792 3093 7187 7189 80143 9868 9641 55593 3661 7311 7314 843 1540 7128 8887 9140 9474 79132 54941 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 993 79858 7157 64326 11200 8454 57060 472 6233 1432 25946 5600 1454 7316 1029 4194 1017 1452 9978 1027 23291 4193 1111 9861 5682 5683 1263 5684 8945 5685 5686 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 1026 7979 5690 5691 5692 5693 5694 5695 5706 5707 2932 5708 51230 5709 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade 1258 2779 5145 6295 5158 6010 1259 5148 2792 9187 2782 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 7157 64326 11200 57060 472 6233 25946 7316 1029 4194 1017 1027 4193 9861 5682 5683 5684 5685 5686 5717 5718 5719 7311 7314 11047 10213 5713 5714 1026 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 51230 5709 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 2767 59345 9630 94235 2769 2793 2792 2791 2790 2782 5321 2788 2787 5028 2786 1432 55970 2776 2785 2784 2783 10681 51764 54331 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 51302 1593 11001 8644 10858 80270 5825 1646 1645 1109 6718 23600 10998 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy 53632 123 5563 5565 10226 5571 5564 3312 51422 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS 1463 1462 10675 1634 63827 22856 633 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation 3768 2570 2569 59345 2567 2566 3773 55879 2771 2770 2782 346562 200959 2773 10681 9568 27020 23229 2774 111 112 113 114 115 2793 2792 2791 2790 2788 2787 2786 196883 2785 2784 2783 51764 107 108 109 3760 3761 2550 94235 3759 3772 2562 2561 2560 2559 2558 55970 2557 2556 2555 2554 3762 3763 3765 3766 54331 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 7316 3665 7099 929 10133 9641 353376 7311 3661 23643 7314 148022 6233 10010 29110 7187 5781 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription 7316 4851 51564 6907 26508 2033 10013 10014 3091 8850 79885 9978 3280 1024 1387 9759 23493 55869 9734 23462 84441 9794 3516 55534 388585 892 83933 7311 8454 7314 6500 3066 3065 6233 22938 79718 2648 7088 7089 9612 10046 26960 9611 7091 8841 4609 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 5892 4331 902 404672 4436 6749 5430 5431 2177 2176 5432 7157 5440 5433 5441 6917 2966 51497 11198 2965 4292 472 3725 8812 1643 5434 5435 5437 545 2968 2967 672 1022 5395 2963 2962 55215 5436 8621 6921 5438 6924 5439 6923 2071 7469 1111 8178 2068 9656 51755 6829 6827 2353 9150 1025 25920 51224 1386 7936 904 905 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors 808 2901 2899 83988 2898 2897 1741 2900 1742 1739 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 6201 6203 6202 6210 51065 6205 6204 6207 6206 6209 6208 6223 6222 6188 6224 6187 6189 6233 6218 6217 8662 8663 8661 8666 8667 8664 8665 27335 3646 51386 8668 8669 10480 1964 6191 6193 6192 6194 6230 6232 6231 6234 6235 6227 6229 6228 1965 8894 1968 3921 2197 140032 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer 1452 6934 4040 7855 4041 83999 1488 1487 8322 8325 79412 8323 54894 89780 27121 5518 22943 27123 1499 64840 8312 8658 80351 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels 3768 59345 3773 2793 2792 2791 2790 2782 2788 2787 2786 2785 2784 2783 10681 51764 9568 3760 3761 2550 94235 3759 3772 55970 3762 3763 3765 54331 3766 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 5687 5688 5689 5700 898 5701 5702 5704 5705 9134 890 8900 595 8454 6233 6502 7316 1019 1017 1027 5753 9861 5682 5683 5684 5685 5686 1163 5717 5718 5719 7311 7314 11047 6500 10213 5713 5714 1026 7979 5690 5691 5692 5693 5694 5695 5706 5707 5708 5709 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation 5864 51209 51762 23682 51552 10890 5870 326624 339122 9230 9363 81876 401258 338382 201475 53916 1122 53917 5861 11021 347517 51560 1121 5872 27314 5873 11031 5869 9609 5862 116442 23011 4218 10981 5878 5867 22931 7879 5868 5874 54734 83452 115827 64284 57799 5865 9545 376267 84932 8934 8766 51715 57403 401409 10966 55647 9367 25837 115273 142684 83871 57111 8073 5875 5876 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade 1675 3004 629 718 3080 4179 1361 1380 10877 10878 730 731 27202 732 975 4153 733 713 735 714 81494 715 930 717 3078 3075 1370 3426 78989 1369 712 966 716 727 2147 728 710 721 1604 722 729 725 1191 1991 7448 719 5627 5648 1378 2220 1401 8547 10584 2219 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants 5518 1452 8312 5519 324 5525 5515 5526 5516 5527 2932 5528 139285 5529 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) 5172 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 1565 64816 29785 54905 8529 126410 113612 57834 1580 4051 1579 284541 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation 6201 6203 6202 6210 51065 6205 6204 6207 6206 6209 6208 6223 6222 6188 6224 6187 6189 1981 6233 6218 6217 8662 8663 8661 8666 8667 26986 8664 8665 27335 3646 51386 7458 8668 8669 10480 1964 6191 6193 6192 6194 6230 6232 6231 6234 1975 6235 1974 1973 6227 6229 1977 6228 1965 8894 1968 3921 2197 140032 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells 2645 6514 5080 207 6927 4821 4825 3170 4760 10000 208 3651 2308 3375 3174 389692 3171 222546 3630 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 2261 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease 2247 5295 2549 5335 2261 10818 5290 4893 6654 2254 8074 2249 3265 2246 8823 8817 26281 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1857 1856 1855 440193 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription 864 865 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis 8370 94239 26277 25913 65057 7013 3013 7329 7014 54386 255626 3018 3017 54145 3014 545 8331 9985 8337 27127 8334 10734 672 8335 50511 93426 10388 23345 23224 474382 256126 56158 6847 644186 23353 8341 8342 3306 8970 8347 8348 128312 8345 8340 55766 9126 8338 10735 10274 25777 8243 5885 85236 8349 4001 8290 8468 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity 7082 2697 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ 5594 4893 5170 5590 3265 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 2956 4436 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 23236 59345 94235 2793 2792 2791 2790 2782 2788 2787 2786 5330 55970 5331 2785 2784 2783 10681 51764 54331 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding 1816 1815 1814 1813 1812 134 135 140 729230 5726 1235 5660 259289 259287 259286 259285 259293 259292 259290 259296 259295 2652 4852 54429 3549 719 80835 80834 1392 6608 2778 5727 2550 718 5443 1081 9568 7852 3375 6753 1234 2914 6010 2847 10266 5196 83756 10203 50831 50833 50832 50834 50837 50836 50839 50838 50840 1908 1906 4157 1910 4161 4160 2642 4159 2641 3060 347148 3972 84109 8620 64106 10886 3062 3061 133 2149 2147 7252 27198 8843 338442 3827 7484 6387 7481 5020 4295 7200 5021 7201 56413 5031 116 5032 54361 117 1909 94233 2798 2797 2796 1907 5028 151 5029 84432 1902 6375 1241 2693 10874 29933 222545 10887 1128 5724 257313 1133 5731 5737 2911 387129 2358 846 2915 8111 2864 8477 2922 6846 2925 10161 6863 185 623 624 56923 6870 2151 23566 2150 3358 3357 3356 6865 2829 2828 6866 6869 885 886 9287 3363 887 3362 2837 3361 9002 3360 57121 338557 59340 153 3814 154 10911 155 2840 3355 2846 594857 83551 301 134864 3269 319100 134860 129521 9038 3354 128674 1132 2867 3352 2865 3274 2863 3351 2862 3350 60675 1129 4922 11255 4923 680 27334 84634 4935 5367 23620 3640 10316 51083 4828 90226 4829 2692 338398 1240 9170 56670 84539 2691 2695 4985 4987 3792 1131 5729 2696 27199 5741 5739 80326 2587 5732 4886 5733 5734 4887 4889 122042 1394 1393 2359 1269 2357 1268 5744 5745 5746 976 5995 4543 4544 259294 2015 353164 6751 5540 6752 5539 116512 54886 10022 79924 6755 6754 8811 10268 10267 57105 339403 51384 151306 136 163404 5697 256933 10800 79948 11211 7504 797 27202 611 51289 799 10692 9934 4142 150 152 8862 51052 114131 9718 7433 6344 7432 6288 6343 727 7434 728 8643 5368 1604 796 30817 117579 5030 53829 183 113091 1903 7473 6915 7472 7475 7477 8326 7476 7479 146 5179 147 7478 148 9890 64748 6019 8698 7480 7482 2918 2917 2916 2913 53637 2912 221391 8484 11251 23596 186 187 9340 165140 50835 2834 2832 2831 1880 2488 283869 2841 57486 7349 2853 2852 4158 2859 50865 1889 2861 1901 64805 9283 9290 9294 59350 84658 1325 2740 2532 7855 7976 8321 8322 7474 8325 8323 1524 8324 7471 2535 5956 351 7483 6348 6469 2793 2792 2791 2790 2788 2787 2786 2785 2784 2783 89780 51764 94235 55970 6351 54331 58191 6352 6354 6357 59345 6356 6347 6349 10850 2826 6361 6364 9034 6363 5473 6366 6367 1230 2782 6360 2833 643 2919 10663 6373 6372 6374 10681 6376 6370 1238 2921 57007 2920 1237 3579 1236 3577 3576 1233 56477 1232 4283 6346 10803 51554 10563 3627 7253 122876 170589 3973 2492 50846 4986 4988 5173 6750 551 552 553 554 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis 9348 2137 90161 2135 9394 9653 26035 221914 9672 2239 222537 11046 375790 2719 3339 9953 9951 8509 2262 64711 6383 266722 10082 6385 64579 6382 2132 2131 2817 3340 9957 9955 9956 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation 5520 3930 5518 9133 2010 22933 983 4001 3837 23592 8815 23141 5515 7443 221496 891 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking 7478 7480 7482 8724 51384 7474 7484 7471 7481 89780 81029 51699 80326 9559 54361 55737 79971 50999 64840 7473 7472 7475 7483 7477 7476 7479 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS 4893 6654 4916 4908 3265 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 147179 2268 917 644150 3055 6850 10006 26999 2534 2214 10458 10451 7525 10787 25 7410 4627 10109 10152 7409 23191 71 4650 4651 4644 695 4620 51517 4641 10552 10163 3071 5747 10093 9844 63916 10092 4067 1398 10095 8976 10094 1793 60 10097 5879 10096 10810 4690 7454 7456 55845 998 5594 5595 8936 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b 4351 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis 10768 3708 3709 5295 5335 5296 5336 122618 5290 5291 3710 917 8398 6850 2209 23646 5581 2214 2212 5580 196051 84513 5337 5338 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 1019 1029 1021 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 2677 2155 2159 5045 2621 2158 2147 8858 5624 632 5627 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones 53905 857 405753 1734 389434 438 1644 1733 7252 1081 7173 5409 50506 1735 7054 1621 90527 51061 121278 7166 15 6528 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases 831 7531 356 3725 6648 351 993 4001 994 995 84290 5052 2309 2801 1020 823 8851 824 7001 826 10018 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 2247 2251 2248 4893 2255 6654 27006 2254 8074 2249 3265 2246 26281 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis 5928 5929 2033 8370 5931 2146 6256 94239 9070 5915 23054 5916 57472 3013 22976 9125 5914 5430 4211 5431 3200 255626 9063 5432 9935 5440 5433 3211 3201 5441 63925 3021 3213 3212 5316 3233 3232 3198 3018 8202 3231 3017 54145 3725 5080 3014 5434 3199 5435 5437 58508 8331 8337 8334 8335 84962 1959 8841 474382 5436 5438 8341 8342 8970 8347 5439 8348 128312 8345 8340 7528 55766 79447 8726 8968 1387 3221 7703 8338 3214 7403 10664 85236 8349 653604 84661 11091 5087 9611 23512 8085 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing 4968 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade 10454 64127 59307 11213 6279 6271 51231 1849 1848 1846 1845 4791 257397 8454 6280 7097 6233 7096 351 4790 948 10333 695 5970 7316 7099 929 7186 23643 23291 841 8767 4792 5608 7334 7335 2353 8945 5518 7311 7314 6500 3654 3656 5594 1386 5595 5604 3551 9261 6197 84166 6196 92610 1147 6195 51135 4205 4214 8517 4208 4615 10392 79155 79671 7157 246330 2002 9097 5599 9252 3146 6285 1326 5609 6288 11274 466 6416 6283 5601 9683 7867 9684 2266 5602 4793 5606 28512 57161 3725 57162 2243 177 23118 121457 28511 80216 5519 1432 5515 5516 5600 5528 5598 2244 6885 114609 7189 51295 8651 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling 3718 5777 5295 5296 5290 3567 5291 1437 5293 3563 3560 3717 3568 3635 3636 8503 6464 1439 1438 9846 6654 3716 3562 3561 3559 3558 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript 55746 29894 23279 22916 79023 10762 23165 1977 6396 4686 10189 129401 8189 9631 7175 51692 4927 10482 8021 5903 9688 23225 55706 23636 348995 9972 9883 11097 23511 81608 57122 8086 53371 53981 8480 10898 79902 55339 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions 3913 10319 3910 3672 3685 3914 3655 3915 80781 3918 3909 3691 4811 3675 3679 22795 284217 3911 3688 3912 3673 3339 3908