CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 808 11261 4772 4773 2353 3562 23523 1437 3559 3558 3458 356 10231 959 55509 5451 8061 9495 1390 2280 3726 3565 5566 5743 4775 1827 3725 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 2353 3725 6670 8850 1385 2033 4092 25942 2625 1019 3915 1017 60436 4609 3312 2908 6667 8648 55802 5931 5933 10499 8928 2309 4208 2308 3693 1030 7050 3172 1745 145258 8819 3567 1026 367 1387 1386 4654 207 2290 23309 6498 7421 6497 7027 2099 1482 3066 3065 1875 79753 1874 6929 3456 1278 51586 51588 4149 4303 2648 5054 4087 4088 4089 10284 9611 1051 7030 7709 5928 860 861 1487 467 864 3586 865 3665 4435 10401 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 11009 3717 8809 51561 3553 3675 6347 4843 8807 916 7297 4283 5295 5970 3594 3593 5290 242 3569 920 3558 2919 3458 6776 3606 3605 112744 4790 4792 6772 7124 4353 6775 6774 149233 29949 9021 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 4193 5903 3065 7341 5905 8554 7514 9759 7329 5901 9063 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 5295 5970 2353 5290 9564 6850 6696 8394 3725 9020 3611 998 10451 5599 5879 3690 5594 9475 5595 2185 387 960 1147 3685 4313 4790 4214 4792 5328 4318 2934 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 4093 90 92 857 93 659 94 4086 5499 2022 3397 3196 2658 3624 409 2280 4089 4092 5594 5595 7043 7046 7048 1460 4090 7040 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 5295 4690 5781 5290 6654 9260 3265 2668 2887 2886 1796 2885 220164 1398 85358 5578 5979 2549 8660 6464 10818 5566 9564 5829 5906 2674 55715 3725 5921 3667 1385 6714 5747 5599 55816 5879 5594 5595 387 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 6382 1291 1290 682 1302 1301 1289 1288 1287 4312 4316 1278 5566 3082 8573 6352 5594 9965 4233 5595 1286 1285 1282 1281 1280 8074 10855 1277 5479 4318 3911 6386 2264 1294 1293 2261 7040 1292 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 808 5581 8831 4893 3958 25780 27342 6654 4763 5579 3265 10156 10235 816 3956 9610 2885 5590 115727 51196 153090 5578 6655 6237 8437 10125 5922 5923 5924 3845 5921 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 9212 6795 3021 3619 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 3717 5295 5290 6776 959 3565 8651 6198 6356 3561 3716 3690 3718 598 3159 3598 3597 4049 5777 6667 4602 3635 4603 6361 2242 246 3566 2113 2475 604 10344 5284 9046 3662 1432 84666 6403 3567 6688 1959 4988 2208 7033 9655 207 7070 383 2971 57379 6777 867 54625 6778 2885 1278 8660 6464 1051 3667 3586 1277 9021 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 808 207 5295 5970 5781 5290 6654 3320 3559 3560 3558 6194 6609 596 2885 3932 5590 8661 7015 7357 259230 9846 1869 6464 6198 3561 5879 3716 3718 598 4609 4602 4790 2309 2475 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 3717 5295 4893 5290 3569 3559 3558 3458 5566 3845 3561 3716 3718 387 5781 6654 3265 3560 2885 3932 9846 2549 2909 3480 6464 3479 10818 10817 4846 4803 7010 5155 8543 3667 3572 3570 284 7422 2770 3459 1950 4908 4909 5159 4301 55824 1956 6383 3791 5894 6772 4914 4915 4916 2773 627 5604 5605 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 3280 256297 3717 2690 23028 2548 3516 2623 55502 367 632 1387 23462 84441 4654 50674 5932 2627 817 2626 3091 9794 9612 23013 920 7291 3065 142 1027 23493 4851 6929 405 429 7528 5925 1869 1827 9611 2033 860 1487 4602 8648 3791 6774 7088 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 3675 3680 3681 3682 3683 3684 3674 3696 3676 3655 3678 3679 22801 3691 3672 3694 3690 3673 3695 8516 3687 8515 3688 3689 3685 3693 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 10735 994 147841 1894 995 699 51343 8945 3796 10112 5515 5518 7178 5058 64689 22981 9055 79682 23291 10403 983 10726 79866 701 5500 5347 55857 54821 4659 4957 3619 9475 387 6790 7465 5861 8555 63967 1062 22974 7283 2801 891 26271 991 151648 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 5932 7323 7520 2177 2176 2175 2130 55120 472 2547 672 1477 2189 898 10111 5591 4361 7332 1017 5111 4683 7157 11073 2188 580 545 2178 5888 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 387 2768 2775 2771 2773 2781 2770 53637 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 116986 572 595 5335 814 1958 815 10971 7532 7531 7534 7533 207 5295 5170 4893 2932 2810 2036 5290 7529 6654 3265 6776 2885 2549 6464 3845 4803 1385 6714 4914 2309 5580 7222 7442 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 8809 8807 1387 916 2353 3123 3122 3559 30009 920 3558 915 3458 917 3659 3606 919 5551 3596 2119 940 941 942 5601 9063 3725 5599 6775 6774 7040 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 699 10112 10403 4691 8452 10051 5684 10592 23468 9212 6795 332 3021 55143 5921 1731 3619 29127 1058 1674 6867 7813 9918 11004 64151 4869 7431 387 5037 6790 23397 90293 9493 3925 5501 54888 5528 4638 55958 151648 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 9423 116986 4651 1612 1630 5335 1793 219699 815 2534 7525 90249 8976 5306 5295 5058 4690 5290 9564 998 6714 5747 5879 5594 5595 387 4131 8633 5604 9844 5605 7204 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 5335 998 8698 2770 10672 5594 5595 387 2768 2775 2771 2781 2773 53637 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 5294 5594 5604 5140 146850 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 3280 5292 23118 595 463 100 10043 947 2623 4893 920 1027 7329 5743 3845 2033 25942 2625 4609 3312 6667 4602 2113 891 6688 1026 1387 4654 4173 6497 6595 4254 8535 3265 8379 1021 22797 4094 596 2944 27044 1211 5897 1278 3950 5657 759 10454 839 4144 5079 6885 4069 161882 4618 9611 1029 1051 51176 2114 5481 290 28996 490 330 1436 3815 1314 136 171558 3015 10401 1991 8900 10155 51701 8826 4353 5250 8089 5530 1052 1050 7471 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 6453 9448 8997 6093 8976 2050 2049 2048 5295 4893 2047 5058 7018 4690 8867 1759 5290 5908 1949 3265 1948 1947 1946 2886 2885 1398 6237 6464 5829 5906 3845 5921 998 6714 5747 5879 5594 5595 5604 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 1432 207 5295 5170 5290 8772 6609 356 5981 695 355 1213 637 836 7430 3551 5601 23017 5291 5608 5609 6850 841 843 8517 8737 5600 329 6714 5602 5599 8837 330 1147 4214 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 10733 10769 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 56848 572 8717 9448 207 5970 8772 6609 596 5590 637 5925 3479 841 8737 5599 7186 5594 8575 330 1950 5610 5595 8844 4609 7132 5074 9530 5154 8567 4790 83939 4214 4792 5894 9131 581 7124 55512 8439 427 6416 5580 1509 5604 54205 5605 8738 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 572 7345 6531 10273 1457 2268 2534 6622 7525 5337 5338 4129 2869 7054 5330 4067 5653 3055 5071 640 1861 9627 11315 3932 2280 6850 6714 7332 2185 5528 5580 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 1432 6850 8945 6714 5295 5970 409 5290 4790 602 4792 5966 3932 3551 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 5337 6093 5338 1386 2353 1027 6550 5590 5585 5586 6456 286205 4659 2151 7430 8395 6722 7414 6548 5608 50855 58 6300 8394 7094 3725 1072 3491 998 57591 5728 5599 23396 5962 4478 1729 9475 4633 3984 11113 387 3985 3688 5606 6416 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 1435 3717 55503 5770 1447 1445 2212 823 7297 5295 5290 6776 3674 9564 3690 387 857 2268 2534 7525 207 4067 6777 3055 640 1796 2885 3932 1398 6464 5155 3667 6714 1950 1436 5159 50507 5618 1956 10253 3630 3952 3953 27040 5617 2241 7295 6774 3643 1000 9021 4904 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 284217 3576 858 10399 3827 2048 2335 51399 3909 23495 2035 4763 1437 3265 836 7430 5566 5921 6714 5599 8573 3673 5594 9965 5595 387 3688 8074 6383 4313 581 6386 2264 5580 2261 7040 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 3845 5594 4893 5595 2353 1326 673 5579 3265 2002 5778 5894 5578 5604 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 3280 595 51561 4843 3576 2353 4763 3569 5268 3458 7042 10856 1850 10891 11221 5451 5156 9555 5925 6401 3727 5601 3726 122953 8452 1466 3048 8739 890 255631 3725 10524 1843 5600 1847 1385 1649 2033 43 5599 1647 1019 5594 598 5595 4313 5328 1432 1386 7054 383 2099 596 5578 672 467 865 3630 9021 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 5335 2268 2534 7525 6093 5294 4067 146850 3055 867 640 1946 3932 1398 6714 10451 22899 1020 1399 2046 285220 7410 2045 387 2044 2043 2042 2041 1943 1942 25791 1969 1944 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 2623 5970 9612 7341 5905 7514 7528 9759 7329 5901 5903 5566 8850 2033 4092 25942 7132 5931 23408 23409 2624 125997 10419 51564 10013 9219 10014 2287 8819 23410 57154 79084 8945 23411 1387 1107 79885 5468 8932 1108 23309 22933 7024 7181 83933 23381 55869 3066 51548 3065 51547 54815 4084 9734 8841 57459 53615 4149 161882 10284 9611 5928 4790 4792 7124 6774 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 3675 5337 5338 1213 9744 3680 8853 1363 23265 9043 9341 274 154 554 3676 1499 3655 60412 3678 23162 3679 55763 22801 999 5898 3672 23396 54536 3831 3673 7253 1495 8516 382 185 8515 1500 3688 55770 1785 3685 10066 4830 3630 10640 6517 11336 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 1452 6502 53944 5899 5934 847 6446 10971 6648 7532 4485 7531 7874 7534 2538 7533 2810 7529 356 1027 7514 5901 3551 5601 8850 2033 5602 5599 1647 1017 1147 2309 891 2308 604 23411 1387 207 5347 4303 1499 5898 7763 114907 10018 1456 1455 1454 1453 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 56848 9630 8698 4363 2770 10672 81537 9294 2767 2776 8879 8877 1903 1901 2769 2768 2775 2771 2781 2773 53637 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 572 1026 10971 7532 7531 7534 7533 207 5170 2932 2810 7529 3320 9882 1027 253260 3836 64223 2931 842 10000 79109 208 4303 4217 5566 6714 5591 598 1147 5894 6517 2309 2475 2308 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 595 207 5295 5290 5908 1398 3682 7082 26999 55740 2889 5906 8907 1499 1739 10163 7074 998 27252 6714 999 3728 2017 23396 5879 10787 10006 3695 1495 382 7410 387 1500 4301 4830 8826 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 207 5295 50937 4043 409 64399 91653 5290 8643 4036 6491 3549 6608 7042 156 55733 6469 5744 2619 50846 2736 5727 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 5347 10733 10769 1263 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 6776 5601 26999 5608 9564 5609 3725 8394 10163 29127 5599 10787 5879 10006 4214 6416 10093 10092 4296 10095 1432 10094 10097 10096 394 5062 1536 10811 1386 396 1535 10458 55845 5330 5058 4688 10109 8936 10152 124056 653361 27035 128239 1398 8395 1499 1072 999 23396 1495 3984 5606 8826 6774 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 25769 5959 2986 388531 2784 145226 54714 5149 10681 407 9626 2979 2978 6011 6121 131890 8787 9227 5146 2793 3000 2780 1261 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 55114 55619 5335 6453 396 29127 998 10451 23229 8412 8874 10928 7410 115557 23268 392 23348 23263 4830 2245 50618 9459 25791 9855 4168 221178 57572 28964 139818 324 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 8553 5460 10370 4891 2056 2034 2395 23411 1387 55662 135 2321 4323 6921 6923 5230 112399 112398 54583 2002 6513 7291 9429 328 7428 3646 405 5054 2033 7422 6667 3791 1942 2113 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 1958 10399 2932 6599 190 354 5451 83637 11143 10498 8805 5152 25803 4193 6256 5608 6258 6257 29843 3725 7182 10524 10513 8850 3817 6605 2033 7113 5599 10481 10919 25898 3301 6736 2908 8648 10499 6416 2624 2308 51564 1432 367 23411 1387 7181 6595 3320 3065 5966 5585 6714 1050 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 6464 2889 5335 857 1457 3725 5295 3716 1399 6461 2353 5290 90525 6654 859 2002 3685 2885 1398 5156 6722 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 2534 3576 6714 2017 8573 9965 9672 5443 5663 1956 181 8074 4160 55851 1463 23385 5764 2264 83464 51107 2261 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 5321 9261 3315 1432 2005 2664 8569 4205 4843 1978 3856 1977 1386 4286 8986 22926 9252 7391 466 7867 5868 2099 10891 6548 5743 3725 1051 5600 1385 1649 7157 4208 26959 8550 3880 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 1793 7534 2335 929 58494 4192 975 4620 120425 7057 5573 1398 7058 5575 7412 93185 5786 5567 10863 5566 9564 5829 6696 3676 7094 6714 5747 5879 10006 382 2185 3688 28964 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 79412 83999 7855 284654 4920 10159 22943 4040 8321 7473 8322 89780 4041 7472 7474 8325 115908 7477 8326 7476 8323 11197 8324 2535 3487 6259 11211 7471 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 23373 2354 595 1906 7205 9988 1997 1958 6347 573 2167 3576 4502 1758 4312 7076 5179 183 4772 3105 4773 2697 2353 4878 3091 6934 3569 1437 3558 3458 1027 8061 3727 3726 3565 4775 3725 1843 1385 2033 4609 2908 6667 4602 5328 4318 2113 2624 7040 3567 1386 7054 2099 983 4094 1278 58 1499 3491 1029 5728 467 3586 7157 865 10018 4097 4922 10987 2355 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 5292 3717 3567 5295 4067 6777 5781 5290 1154 3568 1439 6776 2885 6386 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 595 207 2932 3320 64098 7145 142 11140 81706 253260 10856 391 63916 26472 29780 7514 55742 4659 9815 10398 4666 8607 7791 8440 5829 9793 10460 1499 94274 3725 80895 3611 55679 1385 998 6935 6615 3987 5879 87 1729 8874 6790 9459 8826 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 5770 5335 6093 808 5295 2697 5781 5290 1499 998 3728 5599 2017 23396 5879 8312 2891 4041 3799 1495 4633 1639 818 221955 387 1500 2260 1268 2596 22919 747 2934 2241 1000 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 10062 6720 19 5467 5469 84498 5468 7421 9612 596 6256 6258 6257 6198 8648 7068 7067 7124 5465 3164 5915 5916 5914 9971 7040 7376 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 8626 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 595 9612 6776 190 9759 3725 2033 4609 1147 8648 10499 1509 5469 64714 10011 5457 5458 718 7494 9112 9039 3298 162 4738 322 2099 522 4731 1826 3065 21 8431 9166 4350 5241 9687 8313 9040 286827 6294 80781 79039 6647 3732 135112 4089 8204 8125 9611 672 8543 8202 1051 2100 63977 7031 57658 84458 11331 6418 5111 10521 3823 5617 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 1997 5295 2335 5970 5290 2002 6776 3678 6198 5599 5879 5594 5595 3688 4313 2242 2113 2308 9046 1432 1026 2534 5338 207 5058 4690 6777 5781 2886 2885 1398 6464 5829 4846 7010 5921 5747 284 185 5340 2147 285 51378 79155 4790 1998 2888 2247 7124 660 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 3451 7293 3604 3449 3448 3447 1958 3446 3445 3444 916 567 3443 5581 5588 808 925 4772 4893 926 3105 4773 3455 2353 3454 8320 1961 673 5579 3559 2002 3558 5778 915 917 3458 356 919 5551 8061 5601 3726 4775 3845 3725 5599 3561 5594 5595 3265 3560 5578 5894 7124 3442 3002 6775 3441 3440 5604 8784 5605 3452 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 595 5335 5295 5290 5908 673 23092 9826 11279 64283 50807 6455 11099 824 9815 6237 5601 9564 8440 2889 3725 3678 5599 5879 87 5594 9475 3688 387 3685 2113 6416 3693 9844 1793 2534 7525 8976 5058 4690 6654 2886 2885 1398 2909 7414 5829 58 5906 7094 5921 23162 6714 5747 8874 5894 660 5604 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 3655 284217 3691 3911 3913 3914 3918 3908 3915 3909 3912 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 3280 8945 23291 378708 5883 2177 5982 2176 5884 2175 5983 3364 55120 472 29089 675 672 84126 3014 2189 1111 83990 22909 10111 5810 7517 4361 91442 7398 7156 4683 2187 11073 80233 2188 641 55215 57697 545 57599 2178 6117 5984 5985 79728 6118 80010 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 3280 2194 3084 252983 83439 100 1750 23682 3675 8626 558 1289 11047 3852 10413 10399 64065 7153 3070 9133 2932 5452 2810 7421 6862 3552 83737 55294 2877 624 3861 5525 1749 4851 11059 4193 472 675 1029 861 4361 26959 6236 1052 3486 23541 2355 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 142 5551 637 842 836 841 843 8737 329 7186 7132 7431 8567 4214 581 2934 54205 8738 6720 8717 596 351 397 4926 6709 2620 55367 6304 317 839 834 835 3875 58 837 56616 1073 840 9748 5747 7020 84823 331 1677 1676 330 4000 4001 3984 7150 7124 3002 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events 3576 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 55114 1793 8997 396 6654 5923 5924 7074 29127 10451 5879 10006 8874 10928 7410 64333 115557 29 9181 392 57580 80243 26230 1794 613 9459 25791 5910 50619 4168 221178 1124 57572 2059 1123 9844 7409 7204 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 3383 177 338 6404 6403 4486 1490 83700 3146 4485 5327 6093 4018 5329 7070 3055 5908 3569 58494 4620 3684 5906 7094 5340 387 3689 4313 4790 5328 4318 7124 4035 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 8394 7074 8997 5337 5338 5329 8766 5879 375 5594 9727 5595 382 387 4830 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 5335 5295 5970 8611 4773 5783 2353 10219 5290 7456 5579 7462 8877 2207 1901 2206 2205 3937 3059 695 5319 2213 868 3702 3551 5609 6850 3725 8517 1843 5599 5594 5595 1147 3635 4214 6416 5321 2534 5062 5338 207 4067 5781 867 6654 3265 1796 2885 9846 6464 5829 5921 5747 4790 5894 27040 2241 5604 7409 5605 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 3717 2321 9630 207 10672 2767 2776 1903 2769 7852 10000 5155 6714 7422 5879 2770 5594 5595 5159 387 2768 2775 2771 2781 2773 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 387 3688 5829 3676 5747 7412 3695 8174 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 595 5335 5295 4893 1759 5290 5908 391 5590 5584 6993 9500 9743 5923 23327 4804 3845 2889 25759 4145 55179 53358 7074 998 25 6014 6016 10755 5879 30844 5594 1399 9093 10287 5595 8878 387 9844 1793 5781 6654 3265 2885 1398 9846 2549 6464 10818 10817 5906 4803 5921 4908 4909 23263 4914 4915 4916 6774 627 5604 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 5335 2268 6446 2534 7525 375 5295 5170 4893 5294 4067 146850 3055 5290 640 3265 3320 695 3932 3702 5291 6850 5906 3845 6714 5728 5879 382 9267 9265 387 9266 64411 29760 5336 3635 7535 3636 381 27040 59339 59338 2309 11033 27071 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 10718 3084 3717 51741 23118 1839 2904 6868 2066 2064 2534 685 1742 10413 863 145957 4734 5295 6777 5290 83737 6776 2885 11059 4193 6464 5291 9611 5594 5595 5618 5617 9542 26018 2069 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 5292 3717 6347 7534 1438 5295 4893 3394 4067 5568 2353 6777 5008 5781 5290 6654 1154 1437 3265 1439 6776 2885 9846 3551 5567 6464 5566 6850 3845 5594 5595 3635 5894 6772 6774 5604 5605 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 6640 5608 4137 595 51776 5606 5603 6300 29904 3925 5585 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 6093 4690 5819 57662 4026 4248 4646 360 362 144100 51474 6810 7408 3480 7414 3801 26999 3479 7791 55740 1499 60412 999 23396 3082 10787 87 10006 1729 1950 1495 4633 4233 382 387 1500 4301 1956 1942 11336 1969 28964 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 5335 6093 808 2321 375 5295 5170 5290 673 5579 5608 5566 8440 5600 998 3690 5594 5595 6461 2185 387 5777 3685 2242 9261 1432 857 2534 5062 207 4734 4690 5781 867 23291 3320 2887 2885 5578 2549 7414 9146 5795 5829 4846 3326 7448 1499 9047 8165 26509 6714 5771 5747 10645 1003 7422 1495 5606 1785 3791 5894 8826 5580 5604 5605 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 648 5292 11235 7343 6135 5366 10075 389421 894 3939 1871 84864 9913 5757 3811 3658 8886 7037 91942 5213 6513 2023 3398 1965 661 10856 80177 586 4831 4953 8061 86 3308 4691 8607 332 10524 2033 6615 1019 3159 4869 4609 581 4318 891 1387 1977 9112 3320 7015 4149 2648 4088 4089 23089 8295 7083 790 6470 92140 4683 83879 7157 993 1973 10935 8464 4830 6881 5274 6880 6883 3329 57678 1104 2597 1981 6875 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 1432 5899 2268 2534 5062 7525 5058 4067 3055 640 1850 3932 11221 5063 7189 7786 10454 83605 5592 5608 80824 4215 1843 8737 5600 998 6714 5898 5879 5606 6416 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 3717 572 2056 5295 5170 2932 5290 6776 11184 7006 4145 6591 10019 8651 5287 6198 9402 5599 161742 200734 26228 1399 10603 2057 5595 5800 5777 2309 1387 4286 207 4067 5781 867 6654 4254 3265 2887 596 1796 2885 2549 6464 5728 3815 5894 6772 2241 6774 5604 7409 5605 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 652 5045 2252 2719 6469 5599 5727 5601 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 4843 1438 2335 1437 7412 3680 9564 5829 6696 6714 7422 5879 3688 8751 7424 8038 6303 3772 2162 3371 7052 2515 101 196743 2277 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 64421 3981 11284 1791 27434 200558 2547 79840 54840 27343 7518 5591 7520 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 572 5770 5335 1958 5295 5170 5290 5908 5590 64223 5584 208 9564 8440 2889 3725 998 6615 5599 5879 5594 1399 5595 387 3635 4214 3636 2113 2475 6416 5062 1978 1977 8976 8650 64798 207 3837 10298 5058 200958 4690 30011 5781 50649 867 5868 6654 54453 57521 3265 2060 84335 57610 10048 2885 1398 6456 2151 9846 2549 6464 9146 5795 5829 50855 5906 1499 6714 5771 999 5747 3082 1495 4233 382 5894 5604 5605 324 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 5770 5335 8976 5295 4893 5058 4690 5781 5290 6654 3265 2885 2549 6464 5291 8440 3845 7094 5921 6714 5747 23396 2770 5594 1950 5595 5777 1956 6772 2934 2773 6774 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 6093 396 9630 10672 5295 5330 2767 1759 5290 2776 5579 2769 5582 7225 5585 54331 2149 157 5578 5331 2151 6643 9138 6642 7408 2782 7791 23236 11214 4846 408 2770 9475 4633 387 2147 1785 2768 2775 2771 2781 2773 5580 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 284217 2335 3909 23495 4192 7057 5578 7852 2251 7035 3678 6385 6387 84309 5747 10755 5879 87 6352 5340 387 3688 2147 2260 1785 8038 8324 2247 4318 6386 3371 5580 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 1452 6502 53944 6135 10075 7874 2932 7528 5601 4193 890 10524 8850 25 2033 1111 5599 25898 1017 10419 1432 1387 5515 207 4738 472 1029 7321 9349 5300 11186 28996 8493 80204 387893 1616 6125 7157 64326 4194 91875 1877 545 1434 84148 10155 56950 11200 63970 8445 1456 80854 5580 1455 10848 1454 900 1453 5524 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 6520 3662 5796 5770 1493 2635 1960 1958 3567 79589 1959 10320 1606 3576 50943 808 5588 5468 4772 4773 2353 3562 83737 1961 1437 3559 30009 3558 3458 356 4094 959 55509 5451 868 8061 836 1390 1869 3726 3565 5743 4775 3725 2625 1019 7124 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 1499 3728 999 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 1432 3725 3667 1003 5599 9630 5879 2770 10672 5594 5058 9294 5595 2353 2767 2776 387 2002 2769 2768 2775 2771 2781 2773 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 5335 367 27043 6462 2796 207 5295 5330 2353 5290 3265 54331 5331 2782 23236 1385 998 6714 5747 5879 2770 5594 5595 5336 5894 2775 2771 2781 2773 5604 5605 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 7157 995 11200 898 1263 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 595 9988 6347 632 3576 4312 5329 4256 4772 3162 4773 1634 2697 3909 55787 3976 3713 7056 3569 7392 468 1278 8061 3727 3726 890 4846 4775 3725 1029 2033 3691 6667 4313 5328 4318 2355 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 64421 995 7518 5932 7529 9025 9126 51720 84142 8243 7334 637 7158 9656 7014 5883 2177 4193 5884 472 10524 672 25 3014 10111 4361 1487 7156 4683 993 64326 641 10155 11200 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 8717 5970 8772 356 596 919 355 637 842 836 7185 156110 4217 317 839 835 5609 841 9020 8737 840 5599 8837 7186 330 1616 7132 9530 1147 4790 4792 7124 54205 8738 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 3146 929 3551 653509 114609 6279 1462 23643 148022 8517 633 3654 3656 10333 7099 7098 6288 6280 7097 7096 51135 387 4615 1147 3329 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 3717 3553 7297 3594 3593 3569 30009 3558 3458 6776 3606 3605 3572 2625 3716 9466 6773 3595 3592 246778 10148 6772 7124 6775 6774 7040 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 572 7531 4316 5295 5290 5590 842 836 5584 7189 3551 5601 9500 4804 8517 3654 329 5602 5599 5879 8878 4615 5045 387 1147 5663 55851 4692 4099 23385 57142 6272 83464 11108 51107 8767 27018 54205 28986 4974 10782 55859 6610 6868 56160 388 389 84894 4314 396 207 351 1869 5567 317 839 6464 4803 56616 331 330 4908 4909 5340 7157 4914 10018 627 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 8452 53944 7855 857 1499 4040 8498 55361 85409 89780 8312 1855 2932 59349 1857 1856 5525 2931 8395 324 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 5335 815 632 5329 207 5295 5170 10298 2353 6777 5781 6195 5290 867 6654 54434 2246 152831 54756 4684 2263 2885 2549 6464 10818 6696 3725 6714 999 2017 860 5594 9965 5595 2185 1500 2260 8074 10253 6383 5328 6772 4318 2264 1000 2261 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 4093 90 4089 659 4086 268 269 655 3196 4090 2280 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 595 23028 27043 354 8554 10498 7329 841 3817 10451 7113 2185 5074 10499 2934 7050 5469 367 207 9039 1021 10048 58190 6197 2274 7041 51588 23081 7520 8926 6722 3092 5036 6840 3178 26524 1499 24149 8204 2547 10106 672 1029 146225 23054 55818 8031 896 5591 2288 7337 4824 6925 7110 5052 23598 57178 4117 10401 26060 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 7791 5335 8394 1499 2534 6714 3728 999 207 5879 5295 1495 5290 387 1500 1956 342184 84962 846 208 7408 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 3929 3717 1432 7297 7076 4286 207 5295 2353 5781 3055 5290 6654 3569 3659 2885 8554 9846 2549 3726 5608 3725 8543 1051 5600 3572 3570 5879 3716 598 4609 10401 6772 4170 7184 2266 6774 5791 6416 5580 2308 8600 1052 2 7409 9021 1401 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 2045 2044 2043 2042 1946 1969 2046 285220 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 4176 5521 22897 4171 995 990 54962 8945 50485 8914 5515 7534 5518 7529 23291 5347 5883 2177 4193 5982 5884 5983 890 3364 675 84126 1111 5810 1017 4683 993 11073 545 63967 6117 5888 5984 5985 6118 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 1452 7855 1499 8945 4040 8454 6500 89780 8312 1855 2932 1857 1856 2931 8313 1454 324 1453 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 572 5770 7531 10399 7534 5587 207 5295 5170 5781 5290 6654 3265 2887 2885 5590 1398 8660 3480 6464 3479 9564 8440 5829 3667 6198 5747 1399 5894 5580 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 5608 834 5609 3553 808 118429 5594 22861 728358 5595 45025501 45025512 45025515 84168 5606 3606 7124 5241 7412 6416 5604 5605 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 2782 5959 2986 388531 145226 10681 9626 2979 2978 6010 6295 5145 6011 5158 6121 2792 9187 8787 2779 9227 1259 1258 5148 3000 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 994 6502 595 1387 9133 2353 2099 983 5347 2119 2931 5925 4751 1163 1063 2305 1059 7515 890 3910 4775 9212 7039 332 3175 675 3304 1029 255626 2033 1058 898 1019 1017 4609 6667 4313 11200 2619 891 5604 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 2268 3576 5337 5581 9630 207 5170 5294 5330 4067 409 146850 1759 3055 867 5868 5579 2769 5582 54331 5578 5331 2782 23236 408 3577 156 2771 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 3383 2212 83700 5327 5329 718 7070 3827 959 7412 3681 3683 3684 3491 50848 7045 3386 3385 3384 10417 2244 3687 2243 2811 2159 3689 5624 5328 2266 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 252983 10971 7532 7531 7534 808 7533 207 2932 2810 7529 9882 5590 5584 6810 208 9322 4012 434 3630 6844 5501 6517 23433 2997 5506 3643 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 5521 5770 5335 1445 10971 7532 7531 7534 5581 7533 4893 2810 2353 7529 673 2002 5601 3727 3845 3725 7410 4609 6503 9351 6876 6494 9368 5321 116985 59 9712 5867 93649 9732 2534 81 7525 8976 5294 146850 6777 867 5868 3932 2909 5155 5300 5159 4301 1785 55824 5894 6772 8826 6774 2059 5604 5605 4035 3717 5295 5290 5908 8877 1901 6776 5291 26999 8440 5609 9564 2889 10163 25 5602 5599 2017 10787 5879 10006 3690 5594 5610 5595 8844 387 3685 6416 10093 10092 10095 10094 10097 10096 2268 396 5515 5518 10458 55845 5058 4067 4690 10109 5781 3055 6654 640 3265 2887 1796 2885 1398 6197 5578 2549 6722 6464 5795 5906 5921 6714 5771 5728 5580 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 90 94 2280 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 25945 5817 5818 5797 9076 5295 5290 5908 5819 1398 2889 5906 1499 7094 5155 998 6714 50848 999 5747 23396 5879 3690 1495 7410 5159 4301 3685 8826 9855 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 1445 808 5295 5170 4772 5970 2353 5290 2002 695 2213 7189 3551 6850 11184 3725 8517 5599 5879 5594 5595 7410 818 5777 1147 29760 5336 3635 4214 2113 27071 1432 1457 207 9467 597 5533 4067 5452 10892 25998 84433 6654 5788 4793 3265 971 973 930 1796 974 2885 933 5532 8915 6464 6885 5921 5728 55824 4790 4792 5894 5530 5604 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 116985 1894 394 396 9826 64283 1027 397 4650 7984 55160 23365 9138 2909 393 395 55200 398 11214 57522 50650 4983 10395 9639 10276 10451 23779 10160 22899 23370 9828 7410 64333 115557 387 29 64411 9181 23263 613 25791 50619 4168 7409 7204 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 5185061 25782 10497 6812 6616 6857 6804 6844 3772941 22999 1134 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 4854 6502 4855 595 28514 2011 23028 8076 3516 26292 182 57534 102 8454 1840 84441 6500 4237 8766 10683 5932 1759 9794 9612 23013 2023 4851 7528 3565 2033 2625 4609 5045 8038 55851 23385 83464 51107 1026 8945 8650 867 83737 55294 2060 3065 9611 1487 171558 9148 92737 3714 8788 1272 84708 54567 27255 4853 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 4192 221914 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 1997 894 50943 5295 6777 5781 5290 6654 3559 3560 3558 1021 6776 356 596 2885 3932 5551 9846 6464 3565 890 3561 896 3716 3718 598 4609 4049 6667 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 3084 572 3717 2064 207 5295 9101 4893 4771 10193 2353 5781 2065 5290 6654 1145 4776 3265 85440 2885 5532 5601 6464 5291 5566 3845 3725 998 6714 5602 5599 5879 5594 1134 5595 5894 6774 2475 9542 5604 5605 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 2268 3576 5338 5515 5518 9630 8766 207 5170 5294 5330 4067 409 146850 1759 3055 867 5868 5579 5880 3579 2769 7879 5582 54331 5578 5331 7408 2782 23236 408 1794 2771 9844 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 3170 3169 3171 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 6382 9672 6383 6385 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 6382 1288 3146 5817 1287 5329 7070 2335 8877 7057 3381 1278 2200 3897 5175 3912 10085 961 3674 3910 6696 7448 6385 5155 3491 50848 7045 7422 3690 3915 2244 1286 2243 1285 5159 1282 3685 3791 1277 5328 3371 2266 7048 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 2147 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 5581 5295 4893 2353 5290 1154 5579 3559 3558 3458 6776 5601 10254 22806 8027 3845 6850 8835 3725 5600 8651 5599 3561 3716 3718 5594 1017 5595 2185 4609 387 9046 9261 1432 2534 6777 5781 6654 3265 3560 596 2885 3932 9846 8660 6464 5921 3667 5894 6772 6774 5604 5605 9021 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 2719 2817 221914 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 8553 9575 11091 5187 8864 8914 9572 1111 4862 4841 406 1408 1407 545 1454 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 3717 8809 3553 4843 8807 916 567 7297 925 926 5970 3105 3594 2353 3593 8320 3123 3122 3559 920 30009 3558 915 917 3458 6776 356 7879 3606 919 3565 5608 8651 3561 6351 3001 3554 6348 4616 4791 3595 3142 3592 10912 1234 5971 2475 8767 56848 1432 1386 6778 3560 3932 5606 4790 6772 3002 6775 6774 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 6382 3696 7448 3676 3491 5329 3694 2335 3695 3685 5328 7046 2200 7412 8174 3693 10085 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 1435 6382 1291 1290 1302 1301 1289 1288 1287 6093 5295 2335 5290 1027 10085 9564 841 6696 3611 6198 10451 50848 5879 3690 5594 5595 2185 387 3685 27329 5286 25960 7048 4240 5297 5298 207 5781 867 3320 1278 3480 7414 3479 5829 7448 7094 3667 6714 5747 7422 1436 1286 1285 1282 1281 1280 3791 1277 2247 1294 1293 1292 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 7280 8370 55902 10376 4209 23410 3008 3206 1026 84532 23411 1387 4654 22933 51547 10891 2274 9759 4303 2547 8850 2033 7157 581 2309 2308 155871 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 1432 4331 1387 1022 902 207 5947 7421 9612 983 3065 5582 8841 5578 6256 5566 6258 6257 8204 8850 8202 2033 5599 5594 5595 8648 10499 5915 5916 5914 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 1029 55662 10399 8453 64344 6921 8260 6923 10956 3091 112399 9978 7157 112398 54583 3320 7428 405 10987 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 338 367 1387 7494 2353 162 5265 7026 2099 23761 522 2641 4731 6441 1826 4781 1027 3170 7356 4782 3169 729238 3171 354 5451 1562 4774 725 653509 80781 6647 7448 8204 3725 672 8202 1051 2033 63977 7031 4824 6667 3630 6469 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 1452 23118 815 7525 6093 5468 1855 4773 1857 409 1856 5590 23002 2316 5601 10454 9869 55636 7855 6885 4920 998 5602 5599 5879 7474 115908 387 8323 8324 51701 2535 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 1839 27043 9630 207 10672 5295 4893 5330 2767 5290 2776 6654 2099 3265 2769 2885 54331 5331 3480 6464 2782 3479 6801 23236 9564 2774 4846 3845 5600 2100 6714 2770 4478 9475 387 4313 4318 2775 2771 2781 2773 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 4513 6932 595 10642 814 10971 894 7532 3576 8454 7531 7534 6500 7533 2810 7529 6934 3398 10856 7514 1462 3725 6591 3619 2033 4609 4313 4318 10499 26959 83439 367 8945 4286 1857 6862 3066 3065 7015 8313 7089 6597 27121 1499 6907 113 3491 1029 22943 23043 51176 999 9314 7091 4617 8295 166 3848 1487 4656 607 6925 5308 1044 57680 29969 2249 56998 57167 170261 79718 4762 389058 25776 80333 1046 9968 7088 324 8913 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 3717 1432 5335 2056 5295 4067 6777 5781 867 6654 3265 6776 596 695 2885 2549 8660 6464 2889 5906 7006 10019 5599 1399 598 2057 7410 5777 5336 3635 4790 6772 9021 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 23118 1432 9344 4294 9064 51347 57551 4216 808 816 7189 10454 4217 83605 5608 6885 4215 472 5600 1647 5879 7186 5606 4616 10912 4214 7295 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 6502 5062 5371 5515 9913 2932 55294 5525 10856 86 4149 2648 8607 10524 1029 7709 5300 8312 8295 4609 8464 6881 6880 6883 26959 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 5743 5335 5155 7422 5879 4363 2770 5594 5330 5595 387 5159 8877 1901 3791 2775 2771 2781 2773 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 3084 2268 2534 284217 7525 5320 2321 9353 462 5621 4067 6997 3055 640 3932 351 4087 2817 6714 7422 2260 2247 7043 7046 7048 7040 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 3717 1906 4312 5581 9630 5588 5583 2353 2767 57105 2776 111 112 5579 114 115 1909 2769 1908 1907 196883 1910 10800 107 108 109 9564 3725 998 5599 5879 5594 5595 2185 387 5321 1432 207 5330 3265 5582 6550 7225 1398 1278 5578 5331 6548 23236 2774 113 6714 2770 1281 5894 2768 2775 2771 2781 2773 5580 5604 5605 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 5228 8828 8829 7424 3791 7422 2321 2324 7423 2277 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 572 5335 2534 8976 207 5295 409 4690 5290 7225 2885 5590 2151 5584 5601 7082 5291 50855 8440 23607 55243 4868 3725 7827 5602 5599 5879 6416 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 5335 7205 3576 5581 5587 9630 5295 5970 2932 2353 2767 2776 111 112 114 115 2769 196883 107 836 108 109 5291 9564 3725 23566 7074 1902 2846 9170 5879 147 2185 387 4313 4318 9351 1839 5338 207 10672 4067 4137 3265 54331 1398 5331 2549 9138 2782 5829 113 6714 5747 2770 1956 4790 4792 2768 2775 2771 2781 2773 5580 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 1291 1290 1302 3675 1301 1289 284217 1288 1287 5329 2335 3909 3913 3914 2200 3918 3680 3908 3912 3910 3676 6696 3655 3678 3679 22801 7045 3672 255743 3673 1464 3915 4811 8516 2244 2243 8515 3688 3685 5328 2162 3371 7052 929 58494 4192 975 7057 7058 1278 7412 93185 80781 7448 7422 1286 1285 1282 1281 1280 1277 3911 2266 1294 1293 1292 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 1793 3675 4314 5329 2335 1398 4691 3684 5054 9564 7448 3678 6714 3082 5879 3690 9622 2244 2822 2243 5340 1511 5159 3688 7436 3689 4321 1956 4322 3685 1991 80310 2359 2358 5328 2357 4318 11330 2266 3693 4035 7040 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 595 3398 3956 1027 3655 1385 1649 2033 3691 8837 1647 4609 3688 6667 5933 6278 2672 2309 6908 81855 3158 677 1030 4800 4801 4802 1791 1191 1788 7249 6688 1026 6556 2064 84233 2495 2966 57447 10397 7812 9414 3394 6422 223 10608 23671 3065 596 8841 1278 4149 4087 4088 4089 672 22943 7709 6352 7474 5159 1052 1050 5524 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 10718 3084 1839 7039 2066 2064 685 145957 1950 2065 374 3320 1956 9542 2069 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 7280 51564 10013 10376 10014 814 2623 7531 79885 7529 83933 2099 9612 3320 57763 8625 54880 7341 9734 54331 8841 5905 7514 9759 7329 5901 6722 2782 5903 2908 156 4208 2624 604 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 23118 1490 815 7531 5371 5170 2280 23327 6198 4092 8312 83939 7043 7046 7048 7040 857 57154 5499 10413 5515 409 83737 6654 100506658 64750 7049 2885 11059 23645 9392 168002 6711 25805 5520 10454 9765 83658 6464 54778 50855 5516 4087 6885 11171 4088 4089 9372 1499 1601 331 1616 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 999 3695 3682 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 6885 11184 3725 28988 9402 5599 1399 1326 5579 3937 4214 27040 1398 6416 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 1452 5292 572 814 10971 7532 7531 7534 5581 7533 5588 808 11261 4772 2932 4773 2810 5583 7529 23523 1326 5579 10231 5590 7514 836 9495 2280 5901 5601 5566 4775 1827 2033 5599 598 5595 4214 581 3164 1432 4209 1457 1387 3837 5582 596 5578 3838 8021 23770 5580 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 55503 5335 1445 916 5581 5588 5170 4893 3123 1326 3122 5579 920 915 10235 917 3937 919 940 3702 941 942 7189 3551 10125 3845 11184 8517 9020 998 9402 5777 1147 3635 7535 2534 207 4690 10892 5781 867 84433 6654 5788 3265 2885 3932 8915 5578 9846 2316 6464 5906 28988 5728 83593 7454 84876 6452 27347 6786 2533 84174 55824 27040 7409 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 5335 857 808 2321 207 5295 5170 4690 5781 3091 5290 867 5579 3320 5578 7423 5228 8828 5566 8829 23607 4846 25759 5921 7422 5594 5595 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 6464 6654 1906 3265 1956 1909 2885 2475 1950 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 1452 53944 8819 8945 1387 207 23309 2932 3958 409 23291 3066 3065 3170 54331 8554 7514 2782 5566 10284 5928 25942 2770 9788 27148 51684 6608 8405 11127 5931 8100 6469 2735 2775 2737 2771 26160 2781 2773 51715 1456 2736 5580 1455 5604 5727 1454 1453 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 5770 857 6446 1978 207 5295 5170 4690 5781 5290 867 6654 3265 2887 1796 2885 5590 1398 2151 5584 5786 208 23265 6464 50855 8440 2889 60412 5921 3667 55763 6198 54536 10603 55770 9322 3635 3630 10640 2888 23433 11336 2309 10580 3643 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 5159 5154 80310 5155 5156 56034 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 6464 9564 7074 6714 10451 5747 5879 5295 5058 7410 5290 867 387 1942 3636 2885 1969 52 2909 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 572 1958 10971 7532 7531 7534 808 7533 5170 4893 2810 2353 7529 673 2002 9610 5590 824 5601 3845 3725 1843 1385 598 7410 5037 4208 2475 9712 1386 8976 8986 207 9252 466 5868 6194 5520 5898 1950 1956 5894 6772 8826 1124 6774 2059 5604 5605 5536 378 5607 81624 29895 5598 10746 5900 7538 1848 5295 5290 253260 64223 79109 5291 26999 10163 998 5599 10787 5879 10006 5594 5595 8844 4214 6416 10093 10092 10095 10094 10097 10096 4086 5337 5338 5515 5518 10458 55845 10109 6654 3265 2885 6197 5578 2151 2549 6722 6548 9047 6714 5580 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 1457 8851 7531 7941 808 5048 1778 6249 11104 8941 5050 1600 1641 81565 5049 10726 7804 5649 6993 25 998 5879 1020 4043 387 7436 8826 5528 4131 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 9564 890 10376 1958 389 1026 6714 6093 3672 898 5879 183 5594 5595 1017 387 3688 8073 5875 22809 5876 11156 7803 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 2268 2534 7525 2050 2048 5295 2047 4067 5783 1759 3055 5290 640 1948 1947 3932 5998 3674 8440 6885 7074 6714 5599 5879 3690 6416 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 1432 207 5295 2335 6195 5290 6654 2885 1398 1278 2324 6464 3676 3678 5600 1385 3672 3673 5594 5595 3688 7424 1277 6416 2277 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 9630 409 4690 2767 2776 2769 9744 23527 23303 26034 3973 3674 26269 5829 154 9098 408 116984 51454 9922 6714 3082 3690 7253 1950 4233 382 185 9265 9266 1956 1942 1969 11033 28964 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 100 2623 5371 10399 5970 8611 2810 23493 355 5925 4193 23327 890 10524 675 6273 5600 9540 25 2033 7161 1111 9184 196513 3716 3556 25898 4720 9635 1017 9191 3297 4609 7490 7846 2319 6667 174 27065 578 54894 9518 581 10277 3566 64782 2309 8682 891 9134 200933 1263 3029 27113 2194 23151 51741 5204 1432 699 1026 8626 23411 10413 5265 83737 983 1021 5347 5567 5054 274 835 5300 5888 4914 3714 63970 10018 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 6373 1432 5196 2833 10563 3627 4283 207 5295 5170 4893 1759 5290 3265 253260 54331 64223 79109 2782 5291 5608 408 3845 5600 6714 6356 2770 5594 5595 5606 5894 2775 2771 2781 2773 2475 5604 5605 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 5292 3717 3563 6726 7532 10256 7534 3397 5295 5568 6777 5008 5781 3562 5290 1154 1439 3065 6776 2885 9846 5567 6464 5566 1051 598 3635 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 3383 6093 5581 9630 5588 8766 5583 2767 1759 2776 5579 2769 5590 6401 5592 5566 6850 5600 5879 387 156 7052 9368 1432 2268 2534 7525 5739 207 6915 10672 5729 5294 5330 4067 409 146850 3055 640 5582 3932 54331 157 5578 7412 9138 2782 4846 6714 10681 407 1950 1956 2768 2771 5580 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 4486 2064 284217 10971 7532 4485 7531 7534 7533 207 5295 5376 2810 3909 1308 928 3552 2065 5290 7529 3265 2885 3913 3914 3918 5578 3908 3912 6464 6256 6258 6257 3910 3655 840 6198 999 3691 5879 3915 1950 4233 3688 1956 3911 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 6446 10971 7532 7531 5371 7534 7533 5170 4893 6249 2810 7529 673 253260 10891 64223 7528 79109 3551 3845 6198 5594 1017 5595 2475 54205 6720 7249 1978 8945 5337 5338 1977 64798 207 9821 6195 7248 1975 23291 57521 1938 3265 29904 8408 84335 64121 27250 55615 84271 58528 9706 10670 5578 6009 9776 54541 664 54700 10325 3667 898 1973 5894 5604 5605 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 1147 4791 4790 9020 8945 5971 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 2232 29108 133746 23368 55240 5366 1655 29102 84883 55800 1871 93624 5371 58484 2876 1820 50484 3064 2810 51065 10153 7159 255488 7306 4436 5268 1907 10498 7039 3725 6591 3304 1843 1847 2033 1647 25898 598 6667 1969 604 3486 4800 4801 4802 7249 1026 1387 64065 10397 597 7421 7027 3066 624 596 1869 55367 317 839 2648 5054 834 22943 467 64326 1956 1434 900 9448 3976 3169 355 637 5925 4193 1462 843 6696 6273 9540 7161 174 4313 578 9518 581 891 1509 1263 27113 857 8626 5457 5458 54541 80781 79370 57060 3732 6597 4292 94241 599 57103 27244 7832 5728 639 3082 5395 3090 8295 4068 28984 54487 4233 5111 51499 8812 7157 6890 8794 8795 8793 6376 5564 6880 8797 4170 1870 333926 3276 1643 665 3663 25946 324 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 5566 2774 113 1385 2846 5581 9252 111 112 114 115 196883 107 108 109 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 5770 2534 102 1387 4314 4316 10672 54453 5868 3265 2668 6091 3481 7879 79872 1832 4225 91768 6585 836 10009 5979 6642 3480 9146 2674 1499 7074 25 998 6714 999 3728 5879 1950 1495 4233 382 1500 5777 1785 1956 4830 2768 8826 4915 627 1000 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 994 51343 207 5058 2932 81565 9787 23424 5901 54998 4193 4946 64506 5566 9793 9212 10460 332 5921 672 1058 1647 6867 8874 7157 6790 4792 84962 22974 5528 28964 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 1432 207 5295 5294 5970 146850 5290 6776 959 868 7189 7185 5601 5291 3565 7187 83953 51567 958 3725 9020 722 7128 5600 329 5602 5599 7186 3718 330 598 4609 4790 4214 4792 6416 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 79039 6597 8202 7561 2100 6605 6598 718 9039 4738 8648 8431 190 10499 9040 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 6790 9212 6795 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 2011 7249 10971 7532 7531 7534 7533 2932 2810 7529 7248 4137 2099 57521 3320 84335 11140 64223 7430 5566 4089 1385 51719 9024 6794 4133 5664 23387 57787 114790 4609 7157 84446 51765 6604 150094 92335 23235 200186 2118 55437 2475 1509 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 1948 1947 2050 2049 2048 2047 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 9261 5607 1432 5598 1958 10746 8851 4893 9252 2353 6195 5908 673 3265 2002 6722 5608 5906 3845 1385 6014 6016 1020 30844 5594 4908 5595 5606 5894 23623 4208 5580 5604 7442 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 5871 203447 23118 8717 1540 6610 857 6868 9448 10399 5970 8772 6609 5590 5584 7185 3551 10454 4217 5609 6885 841 4215 8517 8737 7128 23043 329 7186 330 8878 7132 5606 9530 1147 8567 4790 4214 6772 7124 8439 11183 7295 8491 117584 7133 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 3172 7080 3484 2294 6927 211 2645 213 126129 2538 335 207 3157 1375 5313 34 7351 7037 4763 7276 37 3651 1374 3033 622 3170 6898 3169 229 3171 5105 6514 6833 3767 1051 1385 2147 2908 174 6667 3630 8788 1052 1050 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 81624 5581 5295 2932 5290 673 5590 5601 5608 5923 9564 55740 5609 1739 3725 7074 998 6198 5599 5879 5594 5595 7410 4214 2475 6416 10093 10092 4296 10095 1432 10094 10097 10096 5062 7525 5337 1386 8976 396 10458 10298 5058 10109 867 3265 128239 2151 388585 10188 4735 23265 8476 5080 50855 1499 1072 6714 999 1495 4633 8874 3984 3985 5606 5894 9459 8826 2059 324 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 3717 572 5899 1445 916 10399 5295 5170 1759 5290 3123 5908 3122 920 915 917 6776 919 253260 5590 64223 7852 79109 5291 9564 998 5879 2185 387 5777 6773 3635 156 4318 2475 2308 388 2268 2534 389 7525 207 10672 5294 5330 5058 4067 409 146850 6777 5781 3055 54434 83737 640 5788 3932 54331 1398 5331 2782 9146 23236 2870 5829 9525 5996 27183 1072 29979 6387 6714 407 5747 2770 3984 55824 6772 2775 2771 2781 2773 6774 7409 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 9261 994 3315 1432 7249 4046 5600 10971 7532 1385 2115 7531 7534 7533 7054 2810 7867 7529 5894 6929 6722 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 1452 28514 595 5467 3516 1457 6927 8945 102 1387 1840 4734 1855 2932 2353 23291 3065 4851 10454 79412 6885 1499 3725 22943 4040 27123 8321 85407 10023 8312 166 5594 1487 5595 4609 5663 11197 55851 51701 23385 5528 83464 51107 7088 7471 324 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 2232 100 5366 3675 182 10971 5371 5268 355 91768 3551 4193 6273 9540 25 2033 3691 1647 9635 1147 2319 6667 6604 6469 9518 581 64782 4240 26959 3486 27113 1026 8626 1959 8945 64065 7421 83737 2877 11059 5347 1029 23405 26155 9618 6749 4968 7022 132671 9249 2125 667 1728 5580 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 4296 3717 1612 3553 815 1387 808 207 5295 817 5781 5290 867 5908 3458 816 3659 8554 51588 834 2889 5906 1051 8651 5771 2033 4092 3716 3459 1399 5594 5595 818 4214 80142 6772 10379 6774 2475 5580 5604 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 8615 8729 55738 8394 5338 5879 375 1314 9266 920 50807 23647 160 1211 1173 9570 10945 1212 23163 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 23118 3557 54472 3553 23085 7850 7335 353376 11213 5295 5970 3552 5290 5590 7334 7189 5584 3551 10454 834 5608 6885 4215 8517 3725 3654 5599 3556 8878 51135 3554 4615 1147 4790 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 3383 1447 1958 6446 632 3576 8851 4312 3872 7533 7251 5106 4772 5087 5970 2932 1081 2810 2353 2289 6601 6602 3569 1437 9970 30009 7433 3558 51111 3458 6776 6613 3659 5449 6599 3596 5451 6401 5601 3565 4193 5566 3725 5600 1385 2033 5602 5599 1020 2625 5594 5595 2908 5443 174 8648 581 10499 3164 6908 1432 3567 6688 1026 1387 3852 207 5568 6777 3320 3066 3065 3861 5567 6597 2288 7157 4790 6772 5617 2266 5536 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 6453 7251 5295 9101 4893 8867 30011 1759 5290 867 6654 5868 3265 2060 7322 273 2885 29924 10617 868 6456 57732 51652 7323 6464 5291 9146 3845 998 6714 7321 5747 1950 8874 1956 10253 5894 26018 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 5934 990 1871 5932 1027 7528 5925 4172 5422 1066 283848 6822 7515 4605 8409 890 6241 23468 6240 7298 8850 1031 23491 2033 7161 5902 23429 221223 144455 1876 8824 1017 1719 7029 4609 4998 6667 5328 5933 9134 26959 10419 1026 23411 1387 8936 6595 7027 983 3065 1875 1874 1869 317 2648 5054 472 672 1029 840 7030 898 5928 896 8295 3090 7083 993 11073 10155 4170 1870 1050 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 1540 472 23085 8517 8945 7128 329 5970 10892 7132 64127 1147 4790 4792 7124 8915 7514 5578 8767 7189 7323 3551 5901 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 2044 1946 2534 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 55503 5335 1445 916 567 5581 5588 925 5170 4893 926 3105 1326 5579 915 10235 917 3937 919 5551 940 941 942 7189 3551 10125 3845 8517 9020 9402 5777 1147 7535 2534 207 10892 867 84433 6654 5788 3265 2885 3932 8915 5578 6464 5906 83593 84876 6786 55824 27040 7409 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 595 7531 3455 2353 3558 3458 1027 3659 7014 4691 5883 3364 3725 6670 25 6198 25942 5810 5594 5595 4609 7490 7486 641 80119 6667 26277 1736 5931 25913 7013 65057 23293 8658 2475 3183 1489078 57169 7040 10038 54386 54984 10728 8819 207 23309 7026 2099 23381 3320 3066 3065 4084 7015 1869 4149 7520 4088 472 10284 2547 5928 10111 7337 4361 1950 4683 1956 4790 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 6502 595 7343 1997 894 632 1871 1437 7042 1027 5925 5601 4193 890 3725 5600 25 6598 2033 1019 1017 6908 4208 1432 6872 145258 5077 6046 6688 28227 1026 5948 23411 6839 1387 1786 1386 4654 1158 5515 4286 5468 26574 11016 7027 8535 1021 6441 3065 1874 8841 1869 6597 1029 1051 898 5928 896 860 1487 4233 5894 1870 1052 1050 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 4087 4088 4089 10106 3838 8021 808 3837 9972 5594 5494 5595 10217 4214 58190 9392 51588 7329 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 1906 8553 10370 2056 4843 3939 3162 7018 2353 5230 3091 112399 7037 54583 6513 2023 9429 3398 405 7852 3725 1385 2033 4869 5045 3689 6667 8648 10499 2113 2624 51564 3172 3484 1387 2645 7033 2022 207 10397 3099 3098 79365 123 2235 768 5243 6095 133 1356 7015 4907 5236 5315 5211 226 664 5209 5054 4088 4089 6387 7422 3952 4170 10987 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 4296 2904 3675 2534 8851 5048 207 5295 2932 5290 867 1600 4137 7804 5649 2903 9479 8440 5609 2889 5906 5599 1020 1399 4043 3688 7436 9181 4131 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 8717 5295 5290 8772 6609 3551 5291 7818 8743 841 843 8517 8737 5599 8837 7186 5594 5595 8794 1147 8795 8793 4214 8797 6416 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 2782 2774 1432 1392 5600 54331 5599 5601 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 1435 5770 5867 1387 3837 5295 6777 5290 6654 6778 6776 2885 8554 2549 6464 5291 3998 5155 3838 5771 6714 3672 3082 7422 3716 3718 1950 4233 1436 5610 5159 3688 1956 545 3630 3791 83939 6772 6774 3643 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 4093 23118 659 57154 4086 5499 2932 5494 10217 6497 64750 23645 655 58190 25805 9765 10454 6885 4089 25928 10106 91851 4091 8021 9241 4092 197 650 331 148738 654 5594 657 8646 652 285704 9350 56963 26585 10468 4090 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 2782 6093 9630 10672 5330 9475 4633 2767 2776 387 2147 9002 2769 54331 2151