S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1-1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A13;CYP2A6;CYP2A7-1 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 EHHADH-1 ELOVL2 HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation ACAT2 ACAT1 GCDH ECHS1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5D ITPKA INPP5J INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS;CBSL CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS RRM2-1 RRM1 DUT DTYMK NME4-1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 DDC TPH1 AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis SLC27A2 ACSBG2 FADS2 ACSM3 ACSL1 ACSM5 ACSBG1 ACSM4 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 ACAT2 MVK ACAT1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 FDPS L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 ADH1C;ADH1B;ADH1A LRTOMT ALDH3A2 ALDH2 MAOB MAOA COMT PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair GAPDH-1 NAXE NAXD URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C IPMK INPPL1 SACM1L PTEN ITPK1 OCRL PLCB3 PLCB4 SYNJ2 PIK3CA INPP5B ITPKB PIK3C3 ITPKC PLCB1 MINPP1 PLCB2 PI4K2A INPP5A IPPK MTMR3 SYNJ1 PIK3R4 PIK3R3 PIK3R2 PIK3R1 INPP5D ITPKA PIK3R6 PIK3R5 INPP5J PLCG2 INPP5K PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH;LOC102724788 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT GPT2 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing SLC27A4 CERS3 TGM1 ALOX12B CYP4F22 ALOXE3 PNPLA1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD DHODH UMPS GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation GDA NT5C2 PNP-1 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA1 IMPA2 ISYNA1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) UQCRC1 NDUFS2 NDUFS1 UQCRC2 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB10 NDUFB6 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A NDUFC2;NDUFC2-KCTD14 CYC1 NDUFV3 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 COX6C UQCRQ NDUFAB1 NDUFS5-1 COX7B NDUFA13 NDUFA11 NDUFA12 COX4I1 NDUFA10 COX6A1 COX7C UQCRFS1 COX8A SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 AK1 AK2 GMPS AK3 AK5 PFAS AK7 AK8 ATIC GUK1 PPAT AK4-1 ADSL PAICS IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 GART NME4-1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMRK1 NMNAT3 NMNAT2 NMNAT1 NMRK2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt ALDH5A1 GAD1 GAD2 ABAT GLUL GLUD1;GLUD2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) UBIAD1 COQ3 COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 GMPS RRM2-1 GUK1 IMPDH1 IMPDH2 RRM1 NME4-1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME2 NME3 GUK1 DGUOK NME5 DCK NME1 NME6 NME7 NME4-1 AK5 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DIO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP-1 ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GGT5 GSTM3 GSTK1 GSTO2 GSTP1 MGST3 NAT8-2 MGST1 MGST2 GSTT1 GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA4 ANPEP GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 GART ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2-2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 DTYMK CMPK2 NME4-1 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis GPX4 ALOX15 ALOX12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATPAF2-2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP6V1F ATP5ME ATP6V0A1 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP5PD ATP5PB ATP5F1C ATP5F1D ATP6V0E2;ATP6V0E1 ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation SHMT2 SHMT1 MTHFD1 MTHFD1L FPGS L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis PFAS PPAT GART PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis ACAT2 SQLE ACAT1 EBP KCNH7 SC5D DHCR24 DHCR7 LSS FDFT1 HMGCS1-1 FDPS IDI1 MVK GGPS1 IDI2 PMVK MVD HMGCR NSDHL HMGCS2 HSD17B7 LBR TM7SF2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCS2 HMGCL BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR AKR1A1 CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation DBT ACAT2 BCKDHB ACAT1 BCAT1 DLD ACADSB HSD17B10 BCAT2 BCKDHA ECHS1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 BLVRA HMOX2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 ST8SIA2 ST8SIA3 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PCYT1B PCYT1A PEDS1-UBE2V1;PEDS1 CHKA AGPAT1 GNPAT AGPS CHKB FAR1 PCYT2 FAR2 ETNK2 ETNK1 CEPT1 SELENOI L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) TDO2 KYNU AFMID KYAT3 ALDH8A1 IDO2 IDO1 AADAT DHTKD1 KYAT1 GOT2-1 HAAO KMO ACMSD ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A13;CYP2A6;CYP2A7-1 HSD17B1 CYP19A1 HSD17B3 HSD17B7 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3GALT1 ST3GAL3 FUT6;FUT5;FUT3 FUT2 B3GALT5 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III AKR1B15;AKR1B10 AKR1B1 CYP2E1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT1A MAT2B MAT2A PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS NME4-1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2;ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGDS PTGR1-1 CBR1-1 PTGES PTGS2-2 PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation TPTE;TPTE2 INPP4A INPP4B SACM1L INPPL1 INPP5E PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 INPP5F INPP5D MTMR14 INPP5J INPP5K PIP4P2 PIP4P1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 TECR HSD17B12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis GPX4 ALOX5 ALOX15 ALOX12 EPHX3 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGR1-1 PTGES GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S EPHX3 CYP2J2-1 CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX15B DPEP2 LTA4H PTGS2-2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IPPK PPIP5K1 IP6K2 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2-2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 BDH1 OXCT1-1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3B2;ALDH3B1 ALDH1B1 PGM2 DERA ALDH3A1 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX5 ALOX15 ALOX12 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR-1 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 MAOA CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX1 GPX4 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT3 NMNAT2 NAMPT NMNAT1 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM AGPAT1 LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 CDS2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt BPGM MINPP1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III HACL1 ALDH3A2 FA2H GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 G6PC3 PC GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PCK1 FBP1 FBP2 BPGM PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 ALDH2 AOC3 MAOB MAOA AOC2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE;RPEL1 TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 TECR ELOVL1 HSD17B12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) SLC27A2 ACSBG2 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 HSD17B12 ACSM5 ACSBG1 ACSM4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGT5 GGCT GCLC GSS GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 PGM2 PYGB MGAM HKDC1 PYGM PYGL PGM1 HK2 GCK HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation DBT BCKDHB BCAT1 DLD ABAT BCAT2 ACAD8 ALDH6A1 HIBADH BCKDHA ECHS1 HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2-2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1-1 GOT1L1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 PGM2 HKDC1 PGM1 HK2 GCK HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage CDA TK2 TK1 TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 RRM2-1 RRM1 DUT DTYMK NME4-1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA3;GSTA1 GSTA4 GSTA3;GSTA5;GSTA1;GSTA2 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation GDA NT5C2 PNP-1 XDH ADA NT5C3A NT5E IMPDH1 NT5C1A IMPDH2 NT5C1B;NT5C1B-RDH14 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT1A MAT2B CBS;CBSL CTH AHCY MAT2A L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT1A MAT2B ADI1 APIP MTAP MRI1 SRM KYAT1 MAT2A ENOPH1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5J INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 ZFYVE16 BMPR2 BMPR1B ACVR2A SKI SMAD4 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP2 GGT5 LTA4H GSTM4 ALOX5 DPEP1 LTC4S PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B1;HSD3B2 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1;GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II XDH RBP4 RBP5 RBP1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation ALDH3A2 MAOB MAOA COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX15 ALOX12 EPHX3 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1-1 GOT1L1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHB LDHA;LDHC LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III ALDH3B2;ALDH3B1 ALDH1B1 ALDH3A2 ALDH2 MAOB MAOA SAT2 SAT1 ALDH3A1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKMT1A;CKMT1B CKM CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation DBT BCKDHB BCAT1 DLD MCCC2 AUH BCAT2 IVD HMGCL MCCC1 HMGCLL1 BCKDHA GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASRGL1 GOT1-1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation ADH1C;ADH1B;ADH1A ALDH3A2 ALDH2 MAOA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK7 AK8 AK4-1 ADSL AK1 ADSS1 AK2 ADSS2 AK3 AK5 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU AFMID IDO2 IDO1 HAAO KMO UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLD1 PLA2G6 PLB1 PLA2G2A-1 PLD3 PLD2 PLCZ1 OC90 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLCE1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4E PLCB3 PNPLA8 PLCB4 PLA2G4A PLCB1 PLCB2 PLCG2 PLCG1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1-1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK1 PPCS COASY PPCDC PANK3 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation ALDOC TKFC ALDOB TPI1 SI ALDOA KHK PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage NME2 NME3 TK2 TK1 NME5 TYMS NME1 NME6 NME7 CMPK1 CMPK2 CDA DCK DTYMK NME4-1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis PCYT1B PCYT1A CHKA CHPT1 CHKB CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization TDO2 ADH1C;ADH1B;ADH1A KYNU NMNAT3 AFMID NMNAT2 ALDH2 MAOB ALDH8A1 MAOA IDO2 IDO1 DHTKD1 TPH2 DDC TPH1 AANAT ASMT CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GCDH ECHS1 POR ACAT2 CYP4X1 ACAT1 CYP2C9;CYP2C19 CYP2U1 ALDH3A2 CYP2S1 CYP1A2 CYP1B1 QPRT NADSYN1 AKR1A1 HAAO KMO NMNAT1 ACMSD FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) SLC27A2 ACSBG2 HSD17B10 ACOX2 SCP2 EHHADH-1 ACOX1 ACAA1-1 HSD17B4 ACSBG1 HADH ECHS1 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine ALDH3A2 DDC MAOB AKR1A1 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 LARS2 GARS1 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 PNP-1 ADA APRT HPRT1 AK1 AK2 GMPS AK3 AK5 AK7 ADK AK8 GUK1 AK4-1 ADSL IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 NME4-1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC3 DEGS1 KDSR CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 DCTD RRM2-1 RRM1 DTYMK NME4-1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME2 CTPS2 NME3 CTPS1 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine CHDH ALDH7A1 SHMT2 SHMT1 BHMT DMGDH TCA CYCLE%BIOCYC%PWY66-398 TCA cycle MDH1 DLD MDH2 FH IDH3G DLST CS SUCLA2 SDHC IDH3B OGDH SDHD SUCLG2 SDHA SUCLG1 SDHB ACO2 IDH3A N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 HADHA HADHB-1 ACSBG1 HADH ACAA2 ECHS1 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC3 DEGS1 KDSR CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C;ADH1B;ADH1A SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 FUT2 B3GALT5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) ACAT2 TDO2 ACAT1 KYNU AFMID ALDH8A1 IDO2 IDO1 DHTKD1 HAAO GCDH KMO ECHS1 ACMSD PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT-1 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I RBP4 RBP5 RBP1 SDR16C5 ALDH1A3 ALDH1A2 ALDH1A1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL4 ST3GAL3 B4GALT2 B4GALT3 ST8SIA2 FUT6;FUT5;FUT3 B4GALT1 FUT9 CHST1 FUT1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPB1 UPP1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) FADS2 ELOVL5 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis GCNT2 GCNT3 B3GNT2 B4GALT2 B4GALT3 B4GALT1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis GPI TPI1 HK3 PGAM1 HKDC1 PGAM2 ENO1 ENO2 ENO3 HK2 GCK HK1 GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PKLR PFKL PKM PFKM PFKP BPGM HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS;CBSL CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis GCNT3 B3GNT2 B4GALT4 LALBA ST3GAL3 ST6GALNAC6 ST6GAL1 B4GALT2 FUT6;FUT5;FUT3 B4GALT1 FUT2 B3GALT5 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5C2 PNP-1 XDH NT5E IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis TYR DCT TRPC1 TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) NDUFAB1 OXSM MCAT ACSF3 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 HK2 GCK HK1 TREH LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX4 CYP2C9;CYP2C19 EPHX2 EPHX3 EPHX1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RDH8 RLBP1 RPE65 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B1;HSD3B2 HSD17B3 SRD5A2 SRD5A1 CYP17A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME2 NME3 GUK1 NME5 IMPDH1 NME1 NME6 IMPDH2 NME7 GMPS NME4-1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis LIPC BCO1 PNLIP CES2 CES1 RDH8 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RDH11 RDH10 LRAT CES5A DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 GPX4 ALOX5 ALOX15 ALOX12 EPHX3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI HK3 GALE HKDC1 PGM3 GNPNAT1 GNPDA1 UAP1 GNPDA2 HK2 GCK HK1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1-1 CDO1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis SLC27A2 ACSBG2 ACOT2;ACOT1 ACOT4 ELOVL7 ELOVL6 ACSL1 HSD17B12 ACOT7 ACSBG1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 HOGA1 GOT2-1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F3;CYP4F2;CYP4F12;CYP4F11 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism SLC27A2 ACSBG2 PTGR1-1 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 ACSL1 ACSBG1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PGM2 PNP-1 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation CDA TYMP UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 PIP4P1 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I SHMT2 SHMT1 MTR-1 ST20-MTHFS;MTHFS ALDH1L1 MTHFD2 MTHFD2L MTHFR MTHFD1 ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT1A MAT2B AHCY MAT2A ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP-1 ADA HPRT1 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX5 GPX8 CAT GPX1 SOD2 SOD3 GPX7 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C2 PNP-1 XDH ADA NT5C3A NT5E NT5C1A NT5C1B;NT5C1B-RDH14 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AKR1B15;AKR1B10 CYP2E1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis SHMT1 TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 ITPK1 OCRL SYNJ2 INPP5B ITPKB ITPKC INPP5A IPPK SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX15B GPX4 ALOX5 ALOX15 ALOX12 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation LIPC PNPLA2 PNLIP LIPF LIPE DAGLA LIPG PNPLA3 PNPLA4 LPL CEL DAGLB CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 TIGAR PFKFB4 PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) SHMT2 TYMS DHFR2;DHFR ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT3 NMNAT2 QPRT NADSYN1 NMNAT1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1-1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) FADS2 ELOVL5 ELOVL7 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) GCNT2 GCNT3 ST6GAL2 ST3GAL4 B3GNT2 ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CYP2E1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ADH1C;ADH1B;ADH1A ACSS2 ALDH3A2 ALDH2 ACSS1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation DBT BCKDHB MCEE DLD PCCA PCCB MMUT BCKDHA LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO2 FMO3 FMO4 FMO5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALM-2 GALK1 PGM2 GALE PGM1 GALT UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GPI HK3 GFPT2 GFPT1 HKDC1 PGM3 GNPNAT1 UAP1 HK2 GCK HK1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT GPT2 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) ALDH7A1 AASS AADAT DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation HACL1 SLC27A2 ALDH3A2 ACSM1 PHYH-4 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 FDPS THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1;TYW1B TYW3 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I GDE1 PLAAT2 PLAAT5 ENPP2 PLA2G1B NAPEPLD PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ACAT2 ACAT1 ACADSB ACSM1 ECHS1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis TDO2 KYNU NMNAT3 AFMID NMNAT2 IDO2 IDO1 QPRT NADSYN1 HAAO NMNAT1 KMO LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation SLC27A2 ACSL3 ACSBG2 ACSL1 ACSBG1 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DDHD1 DAGLA PLCB1 DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6AMT1 PNP-1 TRMT112 SLC34A2 SLC20A2 SLC20A1 AQP9 SLC2A1 LOC100509620;LOC112267859;AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I PGM2 PGM1 UGP2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2-2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB MPI GPI PMM1 PMM2 GMPPA CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) SHMT2 SHMT1 BHMT DMGDH SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation DBT BCKDHB SDSL DLD SDS BCKDHA GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP-1 HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation DBT BCKDHB MCEE DLD BHMT PCCA BHMT2 PCCB MTR-1 MMUT CDO1 SUOX AHCY MAT2A MAT1A GOT1-1 MAT2B CBS;CBSL CTH BCKDHA TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II FMO1 ADO PPCS ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MOGAT3 PLPPR2 PLPPR3 MOGAT1 PLPPR4 DGAT2 DGAT1 PLPP4 MBOAT7 PLPP3 MBOAT1 PLPP2 MBOAT2 PLPP1 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 AGPAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 MINPP1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1;TYW1B TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I FMO1 CSAD CDO1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle GOT1-1 MDH1 MDH2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 UBE2I XPO1 SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PTPN11 PRKCA PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE DAB2IP PRKCA RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 CALM3;CALM1 EIF3A PTPN11 IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB FRS2 ARHGAP35 PTPN11 IGF1R KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 CENPA SMC4 NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN POMC MC4R APH1A NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 WNT7A FZD8 KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 CALM3;CALM1 KIF5B PTPN11 CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 ELF2 PTPN11 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 ITGA6 LAMC2 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 PPP2R5A WWP1 NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 FRS2 PTPN11 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 MAPK8 APH1A CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FRS2 FOS PTPN11 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 RHO SAG CNGA1 PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B SNAP25 RIMS1 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 NFATC4 MAPK10 PTPN11 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB CXCR2 PRKCA RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 C4BPB SOD1 CYP2C18-1 SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 PRKCA ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 EIF2A WWP1 PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 NFATC1 XPO1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB CALM3;CALM1 PTPN11 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 MST1R PRKCA GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 CENPA AURKAIP1 MDM2-2 GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 KREMEN2 APH1A CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL SHH NQO1 WWP1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A CALM3;CALM1 PTPN11 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 POMC MAPK8 SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD MALT1 ERC1 TNFAIP3 PRKCA RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 PGD TKT HK2 HK1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism ALDOC ALDOB HKDC1 ALDOA KHK HK2 HK1 GALE GALT P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 MAPK14 MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 EIF4E MEF2D MAP3K7 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR RAC3 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway MAPK3 NOS3 BRAF IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 AKT3 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK IL15 PDPK1 IL11RA IL13 IL18 FOS IL1A IL23A IL3RA SOS1 IL6ST SOS2 IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 MAPK6 ELK1 IL12RB1 IL12RB2 STAT5A STAT5B MKNK1 STAT1 MKNK2 IL10RB STAT2 IL10RA STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL9 IL2RB SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis EPRS1 UROD RSAD1 HMBS CPOX PPOX EARS2 COX10 ALAD QARS1 FECH NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CHRNA3 KCNK9 CHRNA5 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA PPP1R1B GNB1 KCNK3 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system PER2 PER1 CRY2 CRY1 TPTEP2-CSNK1E;CSNK1E CSNK1D CLOCK ARNTL CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis MVD PDSS1 HMGCR LSS FDFT1 HMGCS1-1 FDPS SQLE MVK GGPS1 IDI2 PMVK IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIA1 GRIA2 SNAP25 STX19 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 SHANK3 VAMP2 SHANK1 VAMP3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 CDKN1A MAPK13 MAPK11 PIK3CD PIK3CB PIK3C2A AKT2 PIK3CG PIK3C2B AKT3 AKT1 HRAS PDPK1 PIK3CA CCNE1 PIK3C3 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 TP63 SIAH1 PIK3R3 TPTE;TPTE2 PIK3R2 RBL1 PIK3R1 CDK2 CCNG1 CTNNB1 NRAS ATM KRAS TP53 TP73 ATR THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PLCG1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 HRH1 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN1 PRKAR1A GRINA ITPR1 PRKACA-1 GRIN3A PRKCB GRIK5 GNA11 GRIK1 PLCB4 GNAQ GRIN2A HOMER1 PRKX GRM1 GRIN2C PRKACB-1 GRIN2B GRM5 GRIN2D PRKAR1B OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAP2K6 MAP2K3 MAP2K4 JUN MEF2C MAX TXN MAPK14 MAPK9 MAPK12 MAPK8 MAPK13 DDIT3 PLA2G4A MAPK11 BCL2 ELK1 MYC EEF2K STAT1 MKNK1 MKNK2 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 KCNK9 PRKX PRKACB-1 ADCY2 GNAI1 PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A HTR1E GNB1 HTR1F KCNK3 HTR1D HTR1A HTR1B GNAO1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ OXTR PRKCZ PLCG2 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 HTR4 GNAL ADCY2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GABBR2 GABBR1 ADCY9 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 PRKACB-1 ADCY2 PRKAR1B GNAI1 PRKAR1A CACNA1G PRKACA-1 GNAI3 ADCY7 PRKAR2B PRKAR2A GNB1 GNAO1 ADCY4 CACNA1B CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2B UBE2D4 UBA6 UBE2C UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 UBE2G2 UBE2D3;UBE2D2 UBE2D3-1 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 ATG7 UBE2K ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway GSK3B APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 CTNNB1 NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 WNT8A PSEN2 WNT8B LRP4 LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 WNT2 APBB3 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A LRP1B AFDN ACTB-1 NECTIN1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 IL4I1 ALDH1B1 ALDH3B2;ALDH3B1 ALDH2 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 MDM2-2 MDM4 TP63 TP53 TP73 COP1 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK3 PANK1 PPCS DCAKD METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation MAPK3 PPP3CA PPP3CB BLNK VAV3 SYK IKBKB NFKBIL1 VAV1 VAV2 BTK CD79B CD79A CD19 LYN MAP3K2 MAP3K3 CALM3;CALM1 NFKBIA MAPK10 PTPRC PTPN6 GRB2 CD22 CHUK FOS SOS1 SOS2 ITPR1 ITPR2 ITPR3 MAPK14 MAPK12 MAPK13 MAPK11 ARAF PIK3CD PIK3CB PIK3CG RAC1 HRAS JUN PRKCB MAPK9 MAPK8 PRKCD PIK3CA RAF1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 EIF4EBP1 PPP2CB;PPP2CA TP63 AKT2 AKT3 TP53 AKT1 TP73 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis LPL PLA1A PLCB1 PLCB2 DAGLA PLCB3 LIPH MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB PMM1 GMDS GMPPA PMM2 MPI MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN2 RORC MTOR ARNT TXN2 VHL TXN AKT2 HIF1A AKT3 EGLN1 CREBBP AKT1 EGLN3 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C CREB3L1 POLR2C CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L TBP BRF2 TAF12 PRKAR1B BRF1 PRKAR1A MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TBPL2 TAF8 TAF7 TBPL1 TAF6 PRKAR2B TAF4 PRKAR2A TAF2 CREB5 CREBBP OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNAI1 GNG2 GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 POMC GNB2 GNB4 GNAO1 GNB3 GNB5 ADCY2 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1A2 EDN1 MAPK3 GUCY1A1 ADCY9 NOS3 EDN2 EDN3 GNAS-1 ADCY3 ADCY10 AKT2 AKT3 ITPR1 ITPR2 ITPR3 GNA14 GNA11 PLCB3 PLCB4 ARAF GNAQ PLCB1 PLCB2 PRKACB-1 AKT1 ADCY2 PRKAR1B PRKAR1A PRKCG PRKACA-1 PRKCI PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA ADCY7 PRKAR2B PRKAR2A PRKCQ RAF1 GNAL ADCY4 PRKCZ GUCY1B1 ADCY1 EDNRA ADCY8 MAP2K2;MAP2K1 EDNRB ADCY6 PRKG2 ADCY5 MAPK1 PRKG1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis GCH1 FPGS TYMS DHFR2;DHFR 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 HTR2B GNA11 HTR2A GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway CSK LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 COL3A1 LIMS2 BCAR1 MAP3K2 MAP3K3 MAPK10 MAP3K4 MAP2K4 MAPK13 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 HRAS MAP2K3 MAPK9 MAPK8 PIK3CA PIK3C3 RAF1 PXN PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK3 BRAF PTK2 COL16A1 COL12A1 ITGA2B ARPC5L CRKL MAP3K5 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 ELMO1 COL8A2 COL4A5 ELMO2 ACTG1 COL8A1 TLN1 VCL COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 SOS1 PARVA PARVB SOS2 ARPC5 ARHGAP26 COL1A2 LIMS4;LIMS1 ARPC2 COL5A1 ARPC3 ITGA10 MAPK6 COL5A3 ACTBL2 ITGA11 COL5A2 COL20A1 COL9A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ARPC1A ITGB2 ILK LAMC2 SHC1-1 LAMC1 ITGAE RND2 ITGAL RND3 RND1 ITGAX COL10A1 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 ITGA8 FLNA RAPGEF1 ITGA7 COL6A3 ITGA6 ACTB-1 ITGA5 CRK DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 LAMA1 SRC LAMA4 COL11A1 LAMA3 COL11A2 NTN4 ASAP1 CDC42 MICALL1 PTK2B FLNB FYN PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARHGAP42 OPHN1 GRAP2 PDGFRB PDGFRA PDGFRL VAV3 ERF ERG SHC3 VAV1 PDGFB VAV2 PDGFA ARHGAP15 ARHGAP12 SRGAP3 SRGAP1 FLI1 MAP3K2 FEV GRAP ARHGAP9 GSK3A MAPK10 ARHGAP5 ARHGAP6 GRB2 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA JAK1 NCK1 GAB1 GAB2 ETV3 RPS6KB1 ELF1 ELF2 RPS6KB2 ELF3 ELF4 ELF5 RASA1 RASA2 RPS6KC1 PIK3R5 SPDEF MYCBP-1 SRF ELP1 USF2 ELK1 RAB11B RPS6KA4 NIN PKN2 RPS6KA5 MKNK1 MKNK2 MAP3K4 ITPR1 ITPR2 ITPR3 MAPKAPK2 ARAF ARHGAP1 PIK3CD PIK3CB ETS1 PIK3CG ARHGAP8;PRR5-ARHGAP8 HRAS JUN MAPK8 PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 RPS6KA3 RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 JAK3 CHUK PDPK1 FOS SOS1 SOS2 ARHGAP26 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 SHC1-1 ARHGAP10 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A SLC5A7 MYH1 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 CHRNA3 MYH11 MYH10 CHRNA5 MYH7B MYO10 CHRNA4 MYO5A CHRNA6 MYO19 MYO1G;MYO1D MYO9A MYO16 MYO1E MYO1B SLC6A8 MYO1C MYO1A MYO15A MYO5B MYO5C MYO1F CHRNB2 CHRNB4 ACTB-1 CHRNB3 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT4 JAK2 STAT6 JAK1 STAT5A STAT5B STAT1 JAK3 STAT3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PLCG1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 VASP PIK3CA NTN1 NTN3 ABLIM1 NTNG1 NTNG2 UNC5B PIK3R5 DCC NFATC3 NFATC2 PIK3R3 UNC5C PIK3R2 UNC5D PIK3R1 NFATC4 NTN4 RHOU CDC42 PLCG2 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC18A1 SLC6A2 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 INMT COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MAT1A MTR-1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 TUBB3;TUBB6 PFN3 ROCK1 ROCK2 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 LIMK1 ACTG1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 ACTA2 ARPC2 ACTA1 ARPC3 ACTBL2 MYH1 MYH3 ARPC1B MYO3B ARPC1A MYO3A MYH8 MYH9 MYH6 MYH7 MYH13 MYH14 MYH11 MYH10 MYH7B RHOC RAC1 ACTB-1 RHOU CDC42 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade MAPK3 IRS1 IRS2 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 MAP2K3 IRS4 IGF1R INS;INS-IGF2 INSR FOS INSRR IGF2 RPS6KB1 IGF1 IGF2R RPS6KB2 SOS1 SOS2 RASA1 RAF1 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway JAK2 JAK1 STAT1 IFNG IFNGR1 IFNGR2 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UCK1 NME4-1 NME2 NME3 UPRT UPP1 ADAT2 UCKL1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GRIA1 GRIA2 SNAP25 ADCY10 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 GRIN2A SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 VAMP2 VAMP3 GRM4 GRM7 GRM6 GRM8 CACNB1 STX1A CACNA1E VTI1A SLC17A7 GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A GNAI1 PRKACA-1 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 CACNA1B CACNA1A APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway MAPK3 IKBKB MAP3K5 AKT2 AKT3 NFKBIA MAPK10 CHUK FOS IGF2R ATF1 TP53 MAP2K4 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 CASP10 CASP3 TNFSF10 GZMH;GZMB-1 MAP4K2 DAXX ENDOG APAF1 TRAF2 PIK3CD TNFRSF1B PIK3CB TNFRSF1A GZMH-1 MADD PIK3CG LTA LTB CASP9 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF6 ATF3 JDP2 AKT1 BIRC2 ATF4 BIRC3 PRKCG ATF6B MAP2K3 CREM PRKCH XIAP JUN PRKCB RELA RELB CYCS-1 MAPK9 PRKCE MAPK8 BCL2L11 PRKCD RIPK1 BAK1 BCL2 PRKCA FADD PIK3CA MAP2K7 MAP4K3 MAP4K4 MAP3K1 PRKCQ CRADD BIK EIF2AK2 DIABLO-1 EIF2S1 NFKB1 NFKB2 ATF7;ATF7-NPFF PRKRA REL BAX FAS MAP3K14 BCL2L1 MAPK1 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway EXOC2 RALB MAPK3 PLD1 PLD2 BRAF RALGDS RGL1 GSK3B RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 PAK1 PAK3 PAK2 GSK3A MAPK10 GRB2 PDPK1 SOS1 SOS2 SRF ELK1 STAT1 KRAS STAT3 MAP3K4 MAP2K6 MAP2K4 ATF2 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 ARAF PIK3CD PIK3CB ETS1 PIK3CG RHOC RAC3 RHOA AKT1 RHOB RAC1 HRAS MAP2K3 JUN MAPK9 MAPK8 PIK3CA MAP2K7 PIK3C3 MAP3K1 RAF1 CDC42 NRAS MAP2K2;MAP2K1 MAP3K7CL RALA-1 MAPK1 TIAM1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin MAPK3 ITPR1 ITPR2 ITPR3 ARRB1 GNG10 ARRB2 GRK3 GRK2 GNG4 EGR1 AGT GNG8 AGTR1 PLCB3 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PRKCA GNB1 RAF1 ELK1 MAP2K2;MAP2K1 MAPK1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TAF7 TBPL1 TAF6 TAF4 TAF2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway MDM2-2 MDM4 CDKN1A HDAC1 CCNB1 WRN SUMO1 SIN3A CHEK2 SUMO3 TRAF2 SUMO2 HMGB1-1 AKT2 SFN MTA2 EP300 GTSE1 CDKN2D AKT3 GADD45B CDKN2A GADD45A CDC25C AKT1 SIRT1 PML GADD45G KAT2B KAT6B CDK1 PDPK1 PIK3CA CCNE1 PTEN TP63 TPTE;TPTE2 CDK2 ATM TP53 CREBBP TP73 ATR THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway PLCG1 SNAP25 SNAP23 SNAP29 VAMP8 VAMP1 TRH TSHB VAMP2 TRHR CACNB2 VAMP3 CACNB3 CACNB4 STX3 CGA CACNB1 CACNA1E GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI PRKCH GNG2 PRKCB PRKCE PRKCD PRKCA PRKCQ GNB1 CACNA1B CACNA1A PRKCZ PLCG2 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 SOAT1 SOAT2 HSD17B1 HSD17B2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CTNNB1 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 ACTC1;ACTG2 WNT2B FZD10 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ACTB-1 UNTITLED%PANTHER PATHWAY%P06664 untitled RELA SKIL TGIF1-1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle OGDH SUCLG1 SDHC ACO2 PDK2 CS FH PDHA1 MDH1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1-2 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism NT5E DPYSL5 ABAT DPYSL2 DPYS DPYD DPYSL3 UPB1 CDA ALDH6A1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB1 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade MDM2-2 MDM4 PDPK1 IRS4 IGF1R GSK3B TSC2 INS;INS-IGF2 INSR TSC1 INSRR FOXO1-1 IGF2 IGF1 PIK3CA IRS1 IGF2R IRS2 FOXO3 PTEN TPTE;TPTE2 GSK3A HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway PRKACA-1 GNG2 GNG10 GNG5 GNG4 HRH2 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 ADRB3 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 GNAL ADCY2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG2 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 CRHR1 GNB1 CRHR2 POMC GNB2 CRH GNAQ GNB4 GNB3 GNB5 GNAL ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway MAPK3 APP MAPK10 KAT5 PSENEN CACNB2 MAPK7 ADAM17 PKN3 BACE1 CACNA1D CACNA1F BACE2 KLC1 MAPK6 KLC4 KLC3 KLC2 PKN2 CACNA1S MAPK4 APBA1 PKN1 APBA3 CACNB1 APBA2 MAPK15 PSEN2 MAPK14 PSEN1 MAPK12 MAPK13 MAPK11 NCSTN APH1B CHRNA7;CHRFAM7A CACNA1C PRKCG PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PRKCQ PRKCZ MAPK1 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo CXCR4 ROBO1 CXCL12 ABL1 SLIT1 SLIT3 SLIT2 NTN1 NTN3 NTNG1 NTNG2 DCC SRGAP1 NTN4 RHOC CDC42 RAC1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis NME4-1 NME2 NME3 CPS1 CAD CTPS2 CTPS1 DSCAML1 DHODH NME1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PLCG1 MAPK3 BRAF MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 RASA4;RASA4B GAB1 GAB2 RRAS SOS1 SOS2 RASA1 RASA2 PIK3R5 STAT4 STAT6 STAT5A STAT5B STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ERBB4 PEBP1 PEBP4 RRAS2 ARAF GAB3 MRAS PIK3CD PHLDB2 PIK3CB RASAL2 PIK3C2A EGFR ERBB3 PIK3CG ERBB2 PIK3C2B SPRY4 DAB2IP SPRY3 NF1 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 SHC2 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGA SERPINB2 MMP1 MMP3 FGG SERPINE1 SERPINF2 PLAUR PLAT PLG MMP9 MMP13 PLAU FGB PNAT%PANTHER PATHWAY%P05912 PNAT SLC6A3 SNAP25 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 KCNK9 SNAP29 EPB41 PRKX PRKACB-1 ADCY2 GNAI1 VAMP8 PRKACA-1 VAMP1 EPB41L1 EPB41L2 VAMP2 FLNA DRD2 VAMP3 DRD4 SLC18A2 GNAI3 STX3 ADCY7 GNAI2 GNAZ PRKAR2B PPP1CA PPP1CC PRKAR2A PPP1R1B DRD1 GNB1 DRD5 KCNK3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SHH SMO STK36 FBXW11 PTCH1 BTRC GLI1 GLI3 CREBBP MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway SLC5A7 GNG10 ADCY10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A PRKACA-1 SLC6A8 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 KCNJ3 SLC18A3 KCNJ9 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 NPL GFPT2 GFPT1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway MAPK3 ACVRL1 BMP10 BMPR2 MSTN SKIL AMHR2 CITED1 CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 GDF10 SMAD1 GDF11 SMAD4 TGFB2 JUND SMURF2 MAPK10 GDF15 TGFB3 SMURF1 GDF2 BMP8B GDF1 SMAD9 INHBB GDF3 INHBA GDF6 RRAS SMAD6 BMP7 GDF5 INHBC SMAD5 ACVR2B BMP6 ACVR2A INHBE BMP5 SMAD7 GDF7 BMP4 FOSL1 SKI BMP3 GDF9 BMP2 BMP1 GDNF TLL2 CREBBP TLL1 MAP3K7 BMPR1B NODAL BMPR1A DCP1B ATF2 MAPK14 MAPK12 MAPK13 MAPK11 TAB1 EP300 HRAS JUN MAPK9 MAPK8 NRAS MAP3K7CL MAPK1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 TFPI KNG1 THBD VWF F10 GP1BB F12 F2R GP1BA F2 GP5 ITGA2B F3 GP9 PROCR F7 F8 F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 GNA14 GSK3B GNA11 IRS1 GNB2 GNAQ GNB4 GNB3 PIK3CB GNB5 AKT2 PTGER1 FOXO4 CASP9 AKT3 GNGT1 YWHAZ AKT1 GNAI1 PDPK1 INSR FOXO1-1 GNAI3 RPS6KB1 PIK3CA GNAI2 RPS6KB2 SOS1 SOS2 GNB1 FOXO3 PIK3R5 PIK3R3 PIK3R2 PIK3R1 NRAS GNAT2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway GRM3 GRM2 CALM3;CALM1 GSK3A CREBBP GNG10 HRH1 GNG5 GNG4 GNG8 CREB3L3 CREB3L4 GNB2 CREB3L1 CREB3L2 EP300 GNGT1 GRM1 CHRM3 PRKACB-1 CHRM1 GRM5 CHRM5 PRKAR1B HTR6 PRKAR1A HTR7 ADORA3 ADORA1 PHKA1 PHKA2 MTNR1A MTNR1B ADRB2 HRH3 CLTCL1 GNAI3 HRH4 ADCY7 PHKB GNAI2 PRKAR2B PYGB PRKAR2A CLTC HTR1E CLTB CREB5 HTR1F CLTA OPRD1 HTR1D PYGM HTR1A ADRA1D HTR1B PYGL ADRA1B ADRA1A HTR4 GYS2 GNAL GYS1 GNRHR ADCY4 SSTR1 OPRM1 SSTR2 ADCY1 ADRA2C ADCY8 SSTR3 ADCY6 ADRA2B ADCY5 SSTR4 KCNJ3 SSTR5 CREB3 ADCY9 CREB1 ADORA2A ADORA2B OPRL1 ADCY3 PHKG1 GSK3B PHKG2 OPRK1 GPR50 HTR5A HTR2B HTR2A RAP1B ADRB1 RAP1A HRH2 ADRB3 GRM4 GRM7 GRM6 GRM8 ADCY2 GNAI1 CREM PRKACA-1 GNG2 DRD2 DRD4 DRD1 GNB1 DRD5 CHRM2 CHRM4 KCNJ5 KCNJ6 KCNJ9 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway PLCG1 MAPK3 MAP3K6 FRS2 FRS3 FGFR4 FGFR3 FGFR2 FGFR1 MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 PTPN6 RASA4;RASA4B SOS1 SOS2 RASA1 RASA2 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 PEBP1 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B SPRY4 SPRY3 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PIK3C3 PRKCQ RAF1 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis ASL NAGS ASS1 OTC CPS1 CAD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB5 CALML3 PDC GRK1 RHO CNGA1 GNGT1 PDE6B CALM3;CALM1 CNGA3 PDE6A RGS9 RCVRN GNG13 CNGB3 CNGB1 GNG2 GNB1 GNAT1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK15 PSMA1 MAPK3 TH SLC6A3 CCNE2 PLD2 MAPK14 MAPK12 SFN YWHAZ MAPK10 YWHAE PRKN YWHAB PPP1R8;STX12 MAPK9 PSMA7 MAPK8 PSMB10 PSMA8 PSMB7 YWHAQ PSMB3 CCNE1 PSMB1 NDUFV2 YWHAG YWHAH MAPK7 SNCA GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 ELK1 CASK GPR37L1 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 MAPK1 PSMA3 PSMA4 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway ITPR1 ITPR2 SLC5A7 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 GRIN2A CHRM3 GRIN2C CHRM1 GRIN2B GRIN2D GRIN1 PRKCG PRKCI GRIN3A PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PKN3 PKN2 PRKCZ PKN1 SLC18A3 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNAI1 PDYN GNG2 PENK GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 GNB2 GNB4 GNB3 GNB5 ADCY2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 PRIM1 RPA2 POLA1 POLD1 POLD2 TOP1 DNA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis DSCAML1 NME1 AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 RRM2B NME6 NME7 IMPDH2 ADSS1 ADSS2 RRM2-1 GART NME4-1 NME2 NME3 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13B RXRA VDR RARA GC HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway SSTR5 ADORA2A ADORA2B OPRL1 OPRK1 GRM3 GRM2 GNG13 DNAJC27 RAP1B RAP1A GRM4 GRM7 GRM6 GRM8 CACNA1E ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 GNGT1 GRM1 CHRM3 RHOA CHRM1 GRM5 CHRM5 PRKCG ADORA3 PRKCI ADORA1 PRKCH GNG2 PRKCB PRKCE DRD2 PRKCD DRD4 PRKCA CLTCL1 CLTC CLTB PRKCQ DRD1 GNB1 CLTA BDKRB2 OPRD1 DRD5 BDKRB1 GARNL3 ARHGEF1 GPR45 GNAO1 RASGRP2 RASGRP1 RASGRP4 GNRHR RAP1GAP CHRM2 SSTR1 CACNA1B RASGRP3 CHRM4 OPRM1 CACNA1A PRKCZ SSTR2 SSTR3 SSTR4 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis DOK2 DOK3 EPHA3 PLD1 GRB7 PLD2 TCF7 EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PLA2G4D PDGFRB AXIN1 PDGFRA BIRC5 GRB14-1 DLL1 DLL3 DLL4 PDGFB ANGPT1 PDGFA DLK1 APC TEK GRAP NCK2 JAK1 NCK1 RASA1 HSPB1 CTNNB1 MAP2K4 MAPK14 MAPKAPK3 F2R MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 HRAS PRKCG PRKCI PRKCH JUN PRKCB SPHK2 SPHK1 PRKCE MAPK8 PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA GSK3B FRS2 FRS3 CRKL FGFR1 AKT2 AKT3 PAK1 PAK3 PAK2 WNT2B RBPJ FOS WNT5B SOS1 WNT5A SOS2 RBPJL NOTCH2 STAT1 NOTCH1 NOTCH4 STAT3 SHC1-1 DVL1 DVL2 DVL3 WNT1 WNT2 FZD1 TCF7L2 WNT10B RHOC WNT10A FZD3 RHOA FZD2 RHOB FZD5 WNT7B WNT7A CRK MAP3K1 SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM1 RRM2B NME4-1 NME2 NME3 DTYMK DUT ADAT2 RRM2-1 TYMS DSCAML1 NME1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking LOC102724488;SYT15 STX1A STXBP1 SYT7 UNC13D VAMP1 SYT6 RIMS1 SYT12 SNAP25 SYT11 STX2 SYT5 UNC13B UNC13C SYT3 SYT2 RAB3A SYT1 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 ARRB2 BCAR1 EGR1 PPP3CA LYN CALM3;CALM1 NFKBIA MAPK10 GRB2 JAK2 CLU IER3 RPS6KB1 RPS6 RHEB PTGS2-2 CETP EIF4EBP1 ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 SRF RYR1 HSPB1 ELK1 RYR2 ELAVL1 RYR3 CD38 CTNNB1 GAST NOS1 CCKBR EIF4E AKT1S1 MEF2D PPARG HBEGF MAP2K6 GUCY2D MAP2K4 ITPR1 NR2C2 MEF2C AKAP1 HDAC7 BAD MAPK14 MEF2B;BORCS8-MEF2B PTPN11 CCK TPCN2 TPCN1 CAMK4 TRAF6 ARAF PIK3CB PRKACB-1 AKT1 RAC1 PRKCH JUN PRKCB MAPK9 PRKCE MAPK8 PRKCD BCL2 PLA2G4A PRKCA PRKD2 PRKCQ PRKD1 RAF1 PXN NFATC2 PIK3R1 ADCY1 MAP2K2;MAP2K1 MAPK1 PRKG1 PLCG1 MAPK3 CREB1 BRAF PTK2 GSK3B CXCL8 IRS1 ELK4 RPS6KA3 ODC1 ROCK1 RPS6KA1 PAK1 CDH1 PDPK1 YWHAB FOS FOXO1-1 SOS1 FOXO3 MAPK7 ITGB1 STAT3 ATF2 SHC1-1 CASP3 ITGAV RHOA CREM PRKACA-1 MMP3 GNG2 SLC18A2 PLAU CRK GNB1 SRC BAX MAP3K14 CDC42 BCL2L1 PTK2B GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GPI HKDC1 HK2 HK1 TPI1 PKLR PGAM2 BPGM ENO1 ENO2 PFKL GAPDH-1 ALDOA PKM PGK1 PFKM NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway JAG2 JAG1 DLL3 DLL4 DLK1 MAML1 NCOR2 NUMB RBPJL CIR1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 RBPJ GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ABAT ALDH5A1 GAD1 GAD2 CSAD FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway MAP2K4 FASLG CASP7 CASP8 CASP10 CASP3 DAXX MAP3K5 APAF1 CASP9 MAPK10 FAF1 CAPG LMNB2 LMNB1 SCIN CASP6 JUN LMNA DFFB MAPK9 PARP3 MAPK8 GSN PARP4 PARP1 FADD PARP2 CFLAR FAS INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway JUNB VAV1 GRAP JUND JAK2 KRAS ITPR1 ITPR2 ITPR3 MYH1 MYH3 GNA14 GNG10 MYO3B VWF MYO3A MYH8 GNG5 PLCZ1 MYH9 MYH6 GNG4 MYH7 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 ARAF GNAQ GNB3 PIK3CD MYH13 PIK3CB MYH14 PLCB1 PLCB2 MYH11 PIK3CG PLCD4 MYH10 PLCD1 MYH7B PRKX PRKACB-1 AKT1 RAC1 JUN PRKCB PRKCE GNAI3 PIK3CA PREX1 GNAI2 CCRL2 PF4;PF4V1-1 LTB4R2 CCL3L1;CCL3L3;CCL3;CCL18 RAF1 IFNAR1 CCL13;CCL2 C5AR1 FPR1 NFATC3 GNAO1 CCR10 NFATC2 CCR1 XCR1 NFATC1 NFATC4 CXCL10 PRKCZ CX3CL1 CCR9 NRAS CCR8 PLCG2 CCR7 ADCY6 CCR6 ADCY5 MAPK1 CCR5 PLCG1 CCR4 CCR3 MAPK3 CCR2 RHOG CX3CR1 NFAT5 CAMK2D CCL11 CAMK2A MYLK2 CXCL8 CXCR5 BUB1B-PAK6;PAK6 CXCR6 CCL4L2;CCL4L1;CCL4 CCL8 MYLK3 CCL5 COL12A1 MYLK CXCR3 CCL22 ARPC5L CCL21 IKBKB CCL20 CCL27 CCL26 AKT2 ROCK1 AKT3 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 ACTG1 ARPC4 CHUK PDPK1 RRAS SOS1 IFNG ARPC5 CXCR1 ARPC2 ACTA2 CXCR2 ARPC3 ACTA1 CASK ACTBL2 COL20A1 ITGB1 STAT3 CXCR4 IL2 COL14A1 ARPC1B ARPC1A SHC1-1 ITGAL ITGB7 RHOC RHOA ADCY2 GNAI1 PRKACA-1 GNG2 COL6A2 RELA COL6A1 RELB COL6A3 ACTB-1 NFKB2 CDC42 PTK2B XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway HPRT1 PNP-1 PRTFDC1 GDA HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease RHOG GRIK5 GRIK3 GRIK4 ARPC5L GRIK1 GRIK2 TUBB1 TUBB2B;TUBB2A TUBB3;TUBB6 CYFIP2 GRIN2A CYFIP1 HIP1 AP2A1 AP2A2 ACTC1;ACTG2 CAPN9 CAPNS1 GRIN2C CAPN6 GRIN2B CAPN7 GRIN2D ACTG1 CAPNS2 GRIN1 CAPN5 TUBB4B CAPN2 GRIN3A CAPN3 CAPN1 TUBB4A;TUBB;TUBB8B;TUBB8 IFT57 DYNC2H1 DNAI2 ACTR2 FOS DYNC1LI1 DYNC1LI2 RHOJ GAPDHS HAP1 RHOQ DNAH3 DYNC1I2 ARPC5 DNAH7 DCTN1 SP1 DNAH8 ACTA2 DNAH5 TP63 HTT ACTA1 KALRN CYC1 ACTBL2 DYNC1I1 DYNC1H1 BDNF HIP1R CAPN11 CAPN12 TP53 CAPN10 CREBBP DLG4 TP73 DNAL4 MAP2K4 ARPC1B ARPC1A CASP8 CASP3 MAP3K10 GAPDH-1 APAF1 EP300 TBP RAC1 JUN MAPK9 MAP2K7 ACTB-1 TAF4 CLTB CDC42 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism ACLY PC PKM ME1 PCK1 CLYBL CS PKLR PDHA1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation PLCG1 MAPK3 BRAF PPP3CA GRAP2 PPP3CB VAV3 IKBKB VAV1 VAV2 AKT2 AKT3 PAK1 PAK3 CALM3;CALM1 PAK2 NFKBIA PTPRC CHUK NCK2 NCK1 FOS SOS1 SOS2 ITPR1 CD86 CD80 CD3G CD3E CD3D PPP3CC ZAP70 LCK LCP2 CD28 CD247 LAT ARAF PIK3CD PIK3CB PIK3CG AKT1 RAC1 HRAS JUN MAPK9 MAPK8 PIK3CA PIK3C3 MAP3K1 PRKCQ RAF1 PIK3R3 PIK3R2 PIK3R1 CDC42 NRAS MAP2K2;MAP2K1 MAPK1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway MAPK3 MAPK14 TRAF6 TAB1 IKBKB ECSIT TANK TBK1 IRAK1 MAP3K8 IKBKE TICAM2 IRAK4 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TLR9 TLR8 TLR7 TLR10 MAP2K3 CHUK TLR6 JUN NFKBIE TLR4 TLR3 MAPK9 MYD88 MAPK8 TLR2 ELK1 MAP2K2;MAP2K1 MAP3K7 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway TBL1Y CTNNA3 CTNNA2 CSNK1A1 TLE4 CSNK1G3 TLE3 TLE2 TLE1 CHD1L TLE6 PYGO1 PYGO2 TBL1XR1 CSNK1G2 EP400 BCL9 PPP2R5E DACT1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A SMAD1 SAG SMARCD1 SMAD4 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 GNG13 CDH3 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 LRP5 WNT8A WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ARRB1 ARRB2 PPP3CA PPP3CB AXIN1 HDAC1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CREBBP CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 EP300 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 PRKCG FAT2 PRKCI DCHS1 PRKCH FAT3 PRKCB PCDHB3 PCDHB7 PCDHGB7 PRKCE PCDHGB6 PRKCD PCDHGB2 PCDHA8;PCDHA6-1 PRKCA PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PRKCQ PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 NFATC1 CDH15 CDH16 PRKCZ CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 GSK3B PPP3CC GNG2 SMARCAL1 SMARCB1 ARR3 SMARCC1 SMARCC2 CSNK2A2 CSNK2B GNB1 SRCAP NLK PPP3R1 HLTF SIAH2 FBXW11 SMARCA5 TPTEP2-CSNK1E;CSNK1E BTRC CSNK1D INO80 SMARCA1 SMARCA2 SMARCA4 ANKRD6 HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 CTNNA1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway ADA APRT HPRT1 PNP-1 PRTFDC1 XDH TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway STX1A CACNA1E GNG10 SNAP25 ADCY10 GNG5 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 GRM3 GNB5 GRM2 SNAP29 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A VAMP8 PRKACA-1 VAMP1 VAMP2 VAMP3 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CACNA1B CACNA1A GNAT2 CACNB1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI1 PDYN GNG2 GNG10 OPRK1 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 GNB2 GNB4 GNAO1 GNB3 GNB5 AVP OXT-1 ADCY2 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins DPYSL5 DPYSL2 DPYS NRP1 SEMA4D SEMA3A CRMP1 CDK5 DPYSL4 FES PLXNA1 PLXNB1 FRK ARHGEF1 PAK1 RHOA FYN RAC1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNAI1 CACNA1G GNG5 GNAI3 GNG4 GNG8 PLCB3 CNR1 GNB1 GNB2 GNB4 GNAO1 GNB3 PLCB1 PLCB2 CACNA1B CACNA1A GRM1 GRM5 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBPL2 TAF8 TBPL1 TTF1 PSMC3IP RRN3 CAVIN1 TAF1B TAF1C POLR1B TAF1A UBTF POLR1D TBP PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides TK1 ADAT2 CDA BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release CREB1 PDYN PENK GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 ADCY2 GNAI1 CREM PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A GNB1 OPRD1 GNAO1 GNAL OPRM1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG ITPR1 PRKCE PRKCD PRKCA GNA11 PLCE1 PLCB3 PLCB4 ADRA1B ADRA1A PLCB1 PLCB2 ADRA2A ADRA2C ADRA2B LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway AGT ACE REN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD FH ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway NFKBIA IKBKB CD40LG TRAF3 TRAF6 IKBKG CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway AGT ACE REN STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD FH GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway NDUFS3 NDUFS2 XDH CBR3 ABCG2 CBR1-1 NQO1 ABCC1 ABCC2 ABCB1 NOS3 RALBP1-1 AKR1A1 POR NDUFS7 SLC22A16 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLS2 GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT ASNS GLUL ASRGL1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages NFKBIA PRKCB ITPR1 PLCB1 CACNA1D PRKCA CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS MAPK3 CACNA1C NFKB1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNA2D2 CACNB1 ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis ODC1 SMS AMD1 MAT2B SRM MAT2A ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism AGT ACE REN MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACAT1 ACADL ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT ADH1C;ADH1B;ADH1A RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway AGT ACE REN DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis TYR DCT PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism HGD PAH TAT FAH YARS1 GSTZ1 FARSA IL4I1 HPD FARSB GOT1-1 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway AGT ACE REN INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone CREB1 FSHR CGA PPP1CA GNAS-1 GNB1 ADCY2 PRKACB-1 GNGT1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency DDC TH PNMT GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 ACSM2A;ACSM2B GLYAT PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 CRLS1 CDS2 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ABCC2 CYP2D6;LOC107987479;LOC107987478-1 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK PER1 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNAQ CHRM1 GNB1 PLCB1 GNGT1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 FARSA RPL6 RPL7 FARSB RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway AGT ACE REN GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 PGK1 PFKM PKLR SLC2A2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCC5 SULT2A1-4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 CYP2E1 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCG2 GSTP1 GSTT1 ABCC4 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation MMUT PCCA PCCB DBT SDS DLD BCKDHA BCKDHB METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1 MTHFD1L MTHFD2 MTHFR FPGS GGH DHFR2;DHFR FTCD CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 ATP5F1A SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB GAPDH-1 SLC25A4 SLC37A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 GGCX NQO1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SCN1B CYP1A2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway AGT ACE REN OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 GLB1 GAA LCT GLA B4GALT1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP2E1 ALDH3A1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism ACAT1 ACADS OXCT1-1 ACSM1 HADH ECHS1 HMGCL CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway ACAT1 FDPS IDI1 PMVK MVK MVD FDFT1 HMGCS1-1 HMGCR LSS SQLE BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 JMJD7-PLA2G4B;PLA2G4B CDS1 GPAM DGKA PTPMT1 CHAT GPD1 GDE1 LYPLA1-1 CRLS1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway CFB CFD C5 C6 C7 C9 C3-1 CFP C8A NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides TYRP1 CAT SOD2 SOD3 SOD1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway AGT ACE REN WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway SLC2A4 GHR SOCS1 RPS6KA1 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SLC14A2 SLC4A1 SCNN1G ATP1B3-1 AQP2 AQP3 ATP6V1B1 SCNN1D REN SCNN1B SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1A4 ATP1B1 ATP1A3 CA1 ATP1A2 ATP1A1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GAPDH-1 GPD1 GPD2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STAT5A INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD SPTAN1 MAP3K7 PAK2 DFFB MAP2K4 DAXX JUN DFFA PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 TUBB1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 AGXT GPT AARS2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway AGT ACE REN FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 GPX1 DNAJB11 PTGIS ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 SLC22A6 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC3A1 SLC3A2 SLC6A20 SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 AQP1 CA1 SLC4A4 SLC9A1 SLC22A6 SLC22A2 SLC1A1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway MAPK8 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 JUN MAP2K2;MAP2K1 RAF1 HRAS STAT5A EPO MAPK3 FOS ELK1 EPOR CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell ITPR3 CAMKK1 RIMS2 ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CACNA2D2 PRKCA CHRM3 CACNB1 GLP1R CACNA1A RAB3A SLC2A2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin CREB1 PPP1CA GNAS-1 HTR6 GNB1 PRKACB-1 GNGT1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GRIN3A CYP2B6 GRIN2A CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP2C9;CYP2C19 GRIN1 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism CBS;CBSL CTH AHCY MARS1 SLC39A8 METTL6 SCLY MAT2B GGT1 SEPHS2 PAPSS1 MAT2A GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNAS-1 PTGDR GNB1 ADCY2 PRKACB-1 GNGT1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria HGD PAH TAT FAH YARS1 GSTZ1 FARSA IL4I1 HPD FARSB GOT1-1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR4 PLCB1 ADCY1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism SLC19A2 THTPA TPK1 NTPCR TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G PEX13 CRAT PEX14 ACSL1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 FAH GSTZ1 DCT ACSS2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 AGXT GPT AARS2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III GALT GCK UGP2 PGM1 UGDH GALE UXS1 GALK1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway PRKCA PLCG1 AKT1 PLCB1 VAV1 PIK3CG PIK3R6 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NPR1 NAMPT RORA NMNAT3 NMNAT2 CLOCK PPARGC1A SIRT1 NQO1 NADK NMNAT1 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin CREB1 PPP1CA HTR7 GNAS-1 GNB1 PRKACB-1 GNGT1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC22A8 PTGS2-2 SLC22A6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 PRKACB-1 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CYP2B6 AOX1 CHRNA4 CHRNB2 CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 FMO3 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis SHMT1 TMLHE SETD7 BBOX1 ALDH9A1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STAT5A GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA ABCC4 SLC29A1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME2 AK1 AK2 NME1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA ABCC4 SLC29A1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism GCLC CTH LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SRF GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 RASA1 PRKCA CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOS ELK1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1 MTHFD1L MTHFD2 MTHFR FPGS GGH DHFR2;DHFR FTCD FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism AOX1 PDXK PNPO PDXP ALPL NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway AGT ACE REN PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 MARS1 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway SLC28A1 TYMP TYMS CES1 CDA DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism TYR FLAD1 RFK ENPP1 ACP1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACAT1 ACADL ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis PLPP1 AGPAT1 GNPAT AGPS CEPT1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency CHST11 BPNT1 SUOX PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway AGT ACE REN CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME2 AK1 AK2 NME1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation GCK FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 SLC2A2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AOX1 MAOA MAOB SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle SLC2A4 GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 SLC2A2 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect DLST PDHB DHTKD1 MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 TALDO1 PGD PDHA1 IDH3G RPIA IDH1 PFKL PGAM2 ENO1 PGLS SDHC SDHD HK2 SDHA TKT GAPDH-1 SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD PKLR SLC2A2 MDH1 LDHA SLC16A1 PKM ALDOB PGK1 FH ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STAT5A WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) EBP SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR NSDHL ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MTOR MAPK1 TYK2 JAK1 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE CES2 CES1 OPRM1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CASP9 CDC42 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 CHUK AKT1 RAF1 RALGDS RALBP1-1 HRAS MAPK3 ELK1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis HSD3B1;HSD3B2 CYP11B1;CYP11B2 CYP11A1 GNG2 CYP21A2 GNAQ GNB1 AGTR1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis DDC TH PNMT ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria GCLC CTH LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling SRF GNAS-1 GNG2 ROCK1 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR5 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 HRAS PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G PEX13 CRAT PEX14 ACSL1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS-1 DRD1 ADCY2 PRKACB-1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 EPHX1 CYP2C9;CYP2C19 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway PCNA GADD45B CCNB1 CCND1 CCNE1 CDK4 CDK2 BCL2 CDKN1A CDK1 E2F1 BAX APAF1 RB1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMC5 PSMA3 PSMA4 PSMC6 PSMC3 PSMA1 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH CYP2E1 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway CD79B CD79A PPP3CA PPP3CB PPP3CC GRB2 BLNK RAC1 PLCG1 LYN SYK PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 FOS ELK1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism BDH1 ACAT1 OXCT1-1 HMGCL ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STAT5A STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A CHKA PCYT2 PISD PEMT CEPT1 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis TOP2A CAD DFFA CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKACA-1 ADCY10 GNAS-1 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNB1 PRKACB-1 GNGT1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1S C1R C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC C6 C7 C9 C3-1 C8A GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNA2D2 CACNB1 ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NAMPT NMNAT2 NADK AOX1 PNP-1 NNMT QPRT NADSYN1 ENPP1 BST1 NNT NT5C2 NMRK1 NUDT12 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 PTGS2-2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK ABCB1 BCL2L1 STAT5A SLC22A1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism TPH1 ASMT KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 KYNU AFMID CYP1A1 IDO1 AADAT DDC CAT HAAO LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation NFKBIA IKBKB TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA CHUK MDH1 NFKB1 ACACA HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis FSHR GNAS-1 AVPR2 GNB1 ADCY2 PRKACB-1 GNGT1 COAGULATION%SMPDB%SMP0000586 Coagulation VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ADH1C;ADH1B;ADH1A CAT ALDH2 CYP2E1 ACSS1 ALDH1B1 ACSS2 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GALT UGP2 PGM1 HK1 G6PC1 GALE AKR1B1 GLB1 GAA LCT GLA B4GALT1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) EBP SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR NSDHL TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) HGD PAH TAT FAH YARS1 GSTZ1 FARSA IL4I1 HPD FARSB GOT1-1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCG2 ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 TUBB1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NAMPT TP53 NMNAT3 NMNAT2 SIRT1 NQO1 AIFM2 NADK CD38 NMNAT1 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer DLST PDHB DHTKD1 MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 FH PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1A4 SLC12A6 ATP1B1 ATP1A3 SLC12A1 ATP1A2 ATP1B3-1 ATP1A1 REN FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1 MTHFD1L MTHFD2 MTHFR FPGS GGH DHFR2;DHFR FTCD GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency DDC TH PNMT SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway NFKBIA PTK2B BCAR1 PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK PXN RAF1 CXCR4 HRAS PIK3C2G MAPK3 PTK2 GNAI1 NFKB1 GNGT1 CXCL12 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway AGT AGTR1 ACE REN DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 AOX1 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 AGXT GPT AARS2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling NFKBIA IKBKB MAPK8 MAP2K3 ATF1 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 CHUK MAPK14 NFKB1 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids HADHA CPT2 ACADL SLC25A20 HADH CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway CYP2A13;CYP2A6;CYP2A7-1 PCSK2 CYP2B6 AOX1 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 FMO3 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CHRNA3 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CNDP1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle SLC25A11 GOT2-1 SLC25A12 MDH2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway CHDH SARDH ALDH7A1 SHMT1 DMGDH SLC44A1 SLC44A2 MAT2B SHMT2 MTR-1 BHMT GNMT MAT2A PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C2 MBL2-1 MASP2 LOC110384692;C4A;C4B_2;C4B MASP1 C5 C6 C7 C9 C3-1 C8A FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway SLC28A1 TYMP TYMS CES1 CDA L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria ACLY PDHB PC MPC1 SLC25A11 ME1 PDHA1 MDH1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNA2D2 CACNB1 ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CHRM2 HCN4 RYR2 ADRA1A KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) PPT1 HADHA HSD17B10 ECHS1 HADHB-1 ACAA2 MECR THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K3 GRB2 RAC1 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MS4A2 VAV3 MAP2K4 LAT PIK3R1 PIK3CA AKT1 INPP5D MAPK14 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD FH PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GAD1 CSAD ADO GGT6 CDO1 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA ABCC4 SLC29A1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation TP53 BTG2 CHAF1A HOXB9 BTG1 PRMT1 NGF CCND1 FGF1 RB1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNA2D2 CACNB1 ABCC8 INS;INS-IGF2 CACNA1A SLC2A2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium KCNQ4 PRKG2 KCNQ5 ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 GUCY1A1 NOS3 TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PCYT1A SLC22A3 ABCG2 CHPT1 ABCC3 PCYT2 CMPK1 ABCC1 ABCC2 ABCB1 DCK NME1 PGK1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A1 SLC22A2 ABCC4 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 ABCB1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) GALT GCK UGP2 PGM1 UGDH GALE UXS1 GALK1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP2C9;CYP2C19 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 PTGS2-2 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A4 SLC2A1 PNP-1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) HGD PAH TAT FAH YARS1 GSTZ1 FARSA IL4I1 HPD FARSB GOT1-1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine SARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling SRF GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR2 PLCB1 ADCY1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell CACNA2D2 SCN5A SNTA1 CACNB1 GCG ABCC8 SNTB1 SNTB2 CACNA1A SLC2A2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids CPT2 ABCD2 ABCD1 SLC25A20 CROT PEX11G PEX13 CRAT PEX14 ACSL1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNAS-1 GNB1 PTGIR ADCY2 MYL3 PRKACB-1 MYLK GNGT1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 NFKBIA IKBKB TRAF6 IKBKG ECSIT IRAK1 TLR1 TOLLIP TLR9 TLR8 TAB3 RELA TLR7 TAB2 TAB1 TLR6 TLR5 TLR3 TLR2 MAPK8 MAP3K7 LY96 MAP2K4 TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK MAPK14 NFKB1 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis PPCDC PANK1 ENPP1 VNN1 PPCS COASY METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway AGT ACE REN 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ATF2 MAPK8 PRKCZ PAK1 RAP1A PARD6A MAP3K4 BRAF NFKB2 MAPK11 ADORA2A RAPGEF2 ARHGEF7 RAPGEF3 JUN CDC42 PIK3CA MAP3K1 AKT1 CHUK ELK1 PRKACB-1 GNGT1 NFKB1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor PRKCA GNAQ ITPR1 PLCB1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1 MTHFD1L MTHFD2 MTHFR FPGS GGH DHFR2;DHFR FTCD SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria PPT1 HADHA HSD17B10 ECHS1 HADHB-1 ACAA2 MECR ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism GALT GCK UGP2 PGM1 UGDH GALE UXS1 GALK1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CHRM2 HCN4 RYR2 ADRA1A KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway AGT ACE REN BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ7 COQ6 COQ5 COQ3 COQ2 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CNDP1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PDE4D-1 CYP2C9;CYP2C19 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHA ACSM1 ACADM SLC25A20 HADH ECHS1 HADHB-1 ACAA2 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism CHST11 BPNT1 SUOX PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism HSD11B1 PDIA2 UGT1A1;UGT1A6 PDIA6 CYP11B1;CYP11B2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD FH BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 VEGFA KDR NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis CHKA PCYT2 PISD PTDSS1 CEPT1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A YARS1 RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism PLCD3 PI4KA PIK3C3 VAC14 BECN1 PIK3R4 IPPK MIOX ISYNA1 AMBRA1 INPP1 PIK3CA PTPMT1 IPMK ITPK1 FIG4 INPP4A MINPP1 PIKFYVE IMPA1 ITPKA INPP5J PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway ACADSB HADHA CYP2B6 EHHADH-1 ACSM1 IVD HSD17B10 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 LCT SLC2A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway AGT ACE REN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTA1 SNTB1 SNTB2 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 ABCC10 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway PAK1 PCNA RAC1 CAP1 PDGFRA CCND1 WASF1-1 LIMK1 CCND3 CDK5 CDKN1A ACTB-1 MYLK MYL2 VAV3 CFL1 ARFIP2 PPP1R12B PLD1 RPS6KB1 MAP3K1 RALBP1-1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 PGK1 PFKM PKLR SLC2A2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway NFKBIA IKBKB TRAF6 IKBKG TRADD TNF RIPK1 IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B RELA TNFRSF1A IL1A TAB1 MAP3K14 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 CHUK NFKB1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CYP2B6 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 SST GAST CLIC2 SSTR4 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STAT5A ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism JMJD7-PLA2G4B;PLA2G4B FADS2 ELOVL4 ELOVL5 FADS1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism CHDH ALDH7A1 PEMT AHCY MAT2B MTR-1 BHMT MAT2A BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway AGT ACE REN ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A CARS1 RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STAT5A PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 AGXT GPT AARS2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 CES2 CES1 IMPDH2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT ADH1C;ADH1B;ADH1A RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis TG NOX3 CYBB NOX4 CYBA DUOX2 SLC5A5 DUOX1 TPO HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 ATF2 MAPK8 PRKCZ PAK1 RAP1A PARD6A MAP3K4 BRAF NFKB2 ADORA2B MAPK11 RAPGEF2 ARHGEF7 RAPGEF3 JUN CDC42 PIK3CA MAP3K1 AKT1 CHUK ELK1 PRKACB-1 GNGT1 NFKB1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 PGK1 PFKM PKLR SLC2A2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNA2D2 CACNB1 SST ABCC8 CACNA1A SLC2A2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS2 TSC2 TSC1 RHEB SLC7A5 EIF4EBP1 EIF4E MTOR RPS6KB1 AKT1 PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR CBR1-1 PTS SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency BDH1 ACAT1 OXCT1-1 HMGCL BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling SIRT3 TLR4 P4HA3 IL1B NLRP3 HIF1A GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 OPRK1 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin CREB1 HTR4 PPP1CA GNAS-1 GNB1 PRKACB-1 GNGT1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway GNRH1 HBEGF CGA MAP2K3 ATF4 GNAS-1 GRB2 PRKCB SOS1 ITPR1 PLCB1 MAP2K7 CACNA1D PRKCA CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CACNA2D2 SRC CALML6 PLD1 LHB CAMK2A CACNB1 CDC42 GNA11 GNRHR EGFR MAP3K2 MAP3K1 EGR1 MMP2 ADCY1 FSHB ACTN4 ELK1 MAPK14 MMP14 LRRC7 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 NFKBIA IKBKB MAP2K3 EIF2AK2 TRAF6 PPARA IKBKG MAP2K6 ECSIT IRAK1 TOLLIP TLR9 RELA TLR7 TAB2 TAB1 TLR3 TLR2 MAPK8 MAP3K7 LY96 MAP2K4 TIRAP JUN CD14 TLR4 MYD88 MAP3K1 CHUK FOS ELK1 MAPK14 NFKB1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 GPAM PTPMT1 GPD1 AGPAT5-1 CRLS1 CDS2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway NFKBIA PPP3CA PPP3CB PPP3CC GRB2 CD3G RAC1 CD3E PLCG1 CD3D PRKCB SOS1 RASGRP1 NFATC3 NFATC2 ZAP70 SHC1-1 NFATC1 LCK CALM3;CALM1 PTPN7 NFATC4 CD247 PRKCA RELA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 PIK3CG MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 FOS ELK1 NFKB1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC5 SLC28A3 XDH TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 IMPDH1 AOX1 GMPS ABCC4 SLC29A1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNA2D2 CACNB1 CACNA1C ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PTK2B PRKCA PLCG1 PRKCB P2RY2 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type CBS;CBSL CHDH CTH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MAT2B SRM IL4I1 BHMT MTAP MAT2A MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway GRIN3A PPP3CA XDH PRKCA ALDH2 GRIN2A ITPR1 CALM3;CALM1 NOS1 PRKACB-1 DLG4 GRIN1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia AOX1 PDXK PNPO PDXP ALPL PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP5E PI4KA PIP5K1A PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic GCLC CTH LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) NR1H4 SLC10A2 ABCC4 SLCO1A2 GPBAR1 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids CPT2 ABCD2 HACL1 ALDH2 PHYH-4 ABCD1 SLC25A20 PEX13 CRAT PEX14 ACSL1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome GALT UGP2 CANT1 CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 ATP1A4 SLC6A3 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 ATP1A1 HTR1A OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GAMT SARS1 SRR PSAT1 CTH SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production MC2R GNAS-1 GNB1 PRKACB-1 GNGT1 POMC GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway ARNT AHR HSP90AA1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling SRF LPAR6 GNAS-1 GNG2 ROCK1 GNB1 AKT1 ADCY1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis SLC27A5 HSD3B7 AKR1D1 HSD17B4 BAAT CYP46A1 CYP7B1 CYP8B1 CYP7A1 LIPA CYP39A1 CYP27A1 CH25H AMACR ACOX2 SCP2 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway SLC6A2 SLC6A4 CYP2D6;LOC107987479;LOC107987478-1 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin CREB1 CGA PPP1CA GNAS-1 LHCGR LHB GNB1 ADCY2 PRKACB-1 GNGT1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 LCT SLC2A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 SLC2A2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism LIPC LPL PLPP2 GPAM PLPP1 GPD1 AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM GBE1 PYGL HK2 GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis LPIN1 GPAM DGAT1 GPD1 AGPAT1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway AGT GNG2 GNAQ GNB1 AGTR1 ACE REN CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST DHTKD1 ALDH8A1 ACMSD DLD BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 NUDT3 IPMK PPIP5K1 ITPK1 IP6K1 INPP4A INPP4B MINPP1 IMPA1 ITPKA INPP5J ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule CLCNKA;CLCNKB SLC12A3 ATP1B3-1 AQP2 AQP3 REN FXYD2;FXYD6-FXYD2 ATP1B2 ATP4B ATP1A4 ATP1B1 ATP4A ATP1A3 ATP1A2 TRPV5 ATP1A1 SLC8A1 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation CREB1 IKBKB IKBKG MAPK11 PLCB1 PTGS1 PRKCA MAPK1 CHUK NOS3 SUCNR1 MAPK3 NFKB1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 ADSL RRM1 PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ITPA ADA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway CASP1 CASP8 CASP10 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 PRF1 ARHGAP5 ARHGAP32 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CBR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine CREB1 PPP1CA GNAS-1 HRH2 GNB1 ADCY2 PRKACB-1 GNGT1 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis EBP SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACAT2 TM7SF2 SQLE NSDHL LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling LPAR3 GNAS-1 GNG2 GNB1 ITPR1 AKT1 PLCB1 ADCY1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD FH GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors AR PIAS3 SUMO1 VDR RARA NR3C1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis SLC44A2 PITPNB CPNE6 PLA2G3 PGS1 PTDSS2 GPAT4 PTPMT1 CPNE3 GPAT2 CHKB DGAT2 MBOAT7 STARD10 PLAAT3 GPCPD1 CRLS1 ABHD3-2 HADHA PHOSPHO1 ETNK2 LPCAT4 ETNK1 CSNK2B PNPLA3 CHPT1 CSNK2A1;CSNK2A3 LPIN1 MGLL PLA1A PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling EGFR REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition CEP63 AJUBA DYNC1I2 DCTN2 SSNA1 CEP164 CCNB2 ACTR1A CCNB1 TUBA1A CEP250 BTRC CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix COL17A1 COL18A1 COL15A1 TMPRSS6 COL12A1 PLG MMP20 ACAN CAPN9 SCUBE1 ADAMTS1 CAPN7 CASP3 SPOCK3 CTSG MMP7 CMA1 MMP1 MMP9 MMP10 MMP12 ADAM17 PRSS3;PRSS2;PRSS1 BMP1 CAPN10 MMP17 MMP19 TLL1 KLKB1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression POLR2L ZNF382 SETD1B MCRS1 ZNF669;ZNF670 GTF2H3 EPOP CIDEC GATAD2A CDK8 H2BC15;H2BC3;H2BC11;H2BC12 FABP4 TADA2A MYBBP1A CDK5 ERCC3 YEATS2 KANSL2 SCD MED31-1 MPHOSPH8 DGAT2 PHF19 EZH2 LPIN1 MGLL AJUBA PHF20 AKAP8L PSIP1 MED16 MED17 SAP130 UBTF PHLDA1 MEN1 SAP30BP BOD1L2;BOD1 NCOA6 ELOVL5 HCFC1 SAP30 MED23 MED24 AEBP2 PLIN2 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 CXXC1 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 TAF1D SAP30L TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZNF324B;ZNF324 MORC2 PPARGC1B ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PDZD11 REG3G;REG3A-1 RNASE7 RNASE3;RNASE2-2 S100A9 CTSG CHGA PGLYRP2 PRSS3;PRSS2;PRSS1 DEFB129 DEFB127 S100A7A;S100A7 ATOX1 ART1 BPIFB2 BPIFA1 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis DLL3 PSMD8 PSMA6 EPHA4 PSMD12 PSMD11 RIPPLY2 MSGN1 PSMB1 CTNNB1 PSMC2-1 PSMA7 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism PDZD11 SLC5A6 BTD PC ACACB SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC10A6 SLC44A2 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements EXOSC2 EXOSC1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 PABPC1;PABPC3 DIS3 MAPK14 EXOSC6 ZFP36 EXOSC4 EXOSC9 EXOSC8 AKT1 DCP2-1 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state IFT140 IFT122 FUZ KIF7 PSMD8 RBX1 PSMA6 PRKACB-1 PSMD12 IFT52 PSMD11 ITCH SMO PRKAR1A PRKAR2A PSMB1 PSMC2-1 PSMA7 BTRC MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 CRPPA LARGE2 FKTN SLC35A1 SLC35A4 FKRP ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) HDAC1 GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs PSMD8 RBX1 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 DAB2IP RASAL3 SPRED3 SPRED2 SPRED1 RASA4;RASA4B NF1 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD CFB HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle POLR2L GTF2H3 ERCC3 NUP205 NUP107 TSG101 ELL TAF7L PSIP1 NUP85 MVB12A RCC1 NUP88 POLR2G SEC13 PDCD6IP NUP133 XRCC4 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CHMP2B NMT1 UBAP1 GTF2H2C;GTF2H2C_2;GTF2H2 CHMP3 TAF7 TAF5 CHMP6 TAF2 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation HEXB HYAL3 CSPG5 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes UBA7 DDX58 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling AP2A1 AP2A2 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 FRAT2 PPP2R5E RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib CDC37 ERBIN PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 PMPCB SPG7 PHB MICU1 PHB2 MCU PARL KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development JAG1 CTNNB1 EYA1 HOXD11 HOXA11 GDNF PAX8 HNF4A SIX2 LHX1 HOXB4 ID4 HOXA6 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK HDAC1 ALK IRS1 MDK FRS2 PIK3R1 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 SSRP1 GTF2F1 ELL ERCC3 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs TNRC6A-1 CDH11 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF BRD2 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins CYP2D6;LOC107987479;LOC107987478-1 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants CDC37 ERBIN NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD1 KCTD15 SUMO1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX FZR1 UBE2C CDKN2A CDC26 ANAPC1 ANAPC10 ANAPC11 CTNNB1 TNRC6A-1 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection SUMO1 MGAT4A-1 GEMIN2 MAGT1 ZDHHC3 RPS15 TBK1 AKT2 AKT3 RPS11 RPS13 JAK1 ST6GAL1 RIPK2 VPS33A VPS33B SFTPD ANO6 GOLGA7-1 TYK2 AKT1 TUFM TMEM258 DAD1 TLR7 UBE2V1 SNRPF MASP1 ST6GALNAC3 ISCU RPN2 SDC3 RPN1 PIK3R4 DDX20 NOD1 GANAB IRAK1 MGAT5 ST3GAL4 GPC3 VPS11 GPC2 SNRPE-2 GPC4 SNRPG-2 ST3GAL1 ST3GAL3 VPS16 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 NUP205 PTPN11 NUP107 MPP5 SRPK1 RPS25 RPS27 NUP85 ZDHHC9 RPS29 MGAT4B NUP88 IL17F TAB2 SEC13 FAU STT3B NUP133 RPS21 RPS24 IL17A CHMP2B CHMP3 CHMP6 DDX58 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 SSRP1 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 ELL REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels ATP2B2 ATP2B1 SLC8A1 SLC8A2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding CSNK2B CSNK2A1;CSNK2A3 FBXW4 TUBA1A TUBB2B;TUBB2A TUBAL3 SPHK1 GNA14 AP3M1 CCNE1 GNB2 XRN2 KIF13A GNB1 PDCL GNB4 CCT7 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins ZNF382 HDAC1 ZNF669;ZNF670 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZNF324B;ZNF324 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing SNW1 TFDP1 ELF3 TFDP2 ST3GAL6 E2F3 MAMLD1 H2BC15;H2BC3;H2BC11;H2BC12 ST3GAL4 ST3GAL3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NOTCH3 TNRC6A-1 JUN SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 EPAS1 PTK6 EGFR NR3C1 CBL RHOA DOK1 SFPQ-1 STAP2 CRK DOCK1 CCNE1 AKT1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) SUMO1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism PANK4 PDZD11 SLC5A6 PPCS FASN ENPP2 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion ACSL3 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript NUP85 NUP88 DDX39B SEC13 THOC1 DHX38 NUP133 THOC3 THOC6 NUP205 NUP107 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPC6 TRPV6 TRPV4 TRPM8 TRPM4 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TLR4 LY96 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation UBE2V1 BTRC PSMD8 CDC34 TAB2 PSMA6 UBE2D3;UBE2D2 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 BDNF CDK5 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization PTK6 EGFR DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 NUP88 SEC13 NUP133 GCK NUP205 NUP107 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA GINS1 GINS2 CDC45 MCM8 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1-1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation MAPK1 FRS2 RAP1A MAP2K2;MAP2K1 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling PTPN11 FRS2 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly MTTP APOC1 APOB REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNB1 BTRC CCNA1 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism ST3GAL6 PANK4 PPCS FASN ENPP2 ACSL3 GCK RAP1A APOB RPL4 PI4K2B RPL30 RPL31 XYLT2 ENO1 ENO2 RPL6 RPL7 GLS AS3MT NDST3 RPL35 RPL38 PIP4K2C RPL39 ACOT9 STARD3 GSTK1 MECR STARD5 GLCE SECISBP2 RPL22 MED8 CLPS SCO1 MTHFD1 CKMT1A;CKMT1B SCO2 ETHE1 HMBS NHLRC1 UQCRC2 RPL29 IDO2 HACD1 TPH1 RETSAT MTMR4 GNS MTMR6 MTMR7 HSD11B1 ADH4 UGT8 AFMID PLCG2 SLC19A3 SLC19A1 GLYATL3 TCN2 TCN1 OGDH PPT1 PLCH2 ADA LGMN GPI PYGB PRKAG2 PYGM PYGL ECSIT AACS TMEM186 TRMT112 MCEE SMPD1 B3GALT2 ENOPH1 RAB5IF ELOVL1 MIOX ARG2 ITPK1 ELOVL6 TIMM21 PTGR2 ITPKB PLCB4 MTF1 SDHAF1 L2HGDH TKT CHST2 ASAH1 MED28-1 SGMS2 CARNS1 HAS3 SC5D RPL18 MDH1 CKM MDH2 KCNB1 FMO2 NMNAT2 GNMT AGMAT LYRM2 GATM FABP3 LYRM4 FABP5 FABP6 COQ8A CRAT PLCD1 KCNG2 VKORC1L1 SLC27A1 ALDH1L1 FADS2 PPP1CC ABHD10 UROD MPC2 RPL37A-1 CHP1 FADS1 NUDT12 DIO1 PIPOX SLC25A51;SLC25A52 ACLY RPE;RPEL1 SLC27A5 PFKFB2 PFKFB1 PFKFB4 SLC26A2 CEMIP PFKFB3 GSTT1 HMMR ABHD5 AK6 SLC9A1 MTM1 NDOR1 AMDHD1 PSAP MPC1L HACL1 KDSR IP6K3 IP6K2 ESRRA COA3 M6PR G6PC1 SYNJ1 ACO1 HPSE SERINC3 SERINC2 SERINC4 AMD1 FHL2 GADL1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PIK3CG PIK3C2B RPL7A SPR ME1 IDH3B PGM2 UGT2A1 SLC37A4 LBR PGM1 CERS3 CERS6 GGPS1 APOA2 APOA1 ARNT APOA4 INMT ADRA2A SLC25A18 SLC25A17 SLC25A10 ASPA ST6GALNAC5 CERS1 CERS2 NDUFB8 NDUFB6 NME4-1 GLS2 NDUFB4 NDUFB2 NDUFB1 PPM1K HSD17B10 SRM SLC25A27 D2HGDH SLC25A21 IARS1 TSPOAP1 CYB5A NDUFA7 MMAB TXNRD1 NDUFA3 APOC3 PTPN13 BCKDK TMLHE UROC1 RAB14 APOC2 NAGS FOLR2 CDO1 PFKP DMGDH SLC35B3 SLC23A2 SLC46A1 AHCYL1 CERK SLC23A1 ACSM5 ACSM4 MTR-1 HS6ST2 NUBP1 CBS;CBSL PPAT CHAC1 CIAO2B MFSD2B PTGDS SEPHS2 GLUL GALM-2 CPT1A ENTPD4 ENTPD8 TALDO1 BCS1L SLC52A1;SLC52A2 CYP39A1 INPP4A POR PPA2 PPP1R3C VDAC1 TRIB3 ALDH7A1 CES2 RTEL1 SMIM4 MAOA MTARC1 MGST3 SLC35D2 MGST1 PHYH-4 PIK3R5 INPP5B NEU3 INPP5F ARSJ NEU1 ARSH ARSI ASL B4GALNT1 APOE PCK1 DECR2 B4GALNT2 CTSA TRAP1 SLC10A2 PYCR2 PYCR3 PAICS DERA AIMP1 CYP2S1 ACER3 NDUFAF2 C12orf73 NDUFAF1 GSTA3;GSTA5;GSTA1;GSTA2 CD320 MOGAT3 MOGAT1 TECR AKR1B1 HSCB COX7C INS;INS-IGF2 SLC22A13 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 AUH NNT TNFAIP8L1 FFAR1 STARD3NL GAA AMPD2 AMPD3 CYP7B1 NME1 NME6 FAM20B B3GNT2 PPA1-1 AGL-1 NUDT11;NUDT10-1 AHCY INPP1 GDPD1 HSD17B4 FITM1 AKAP5 TYMS GDPD5 CYP7A1 GNAI2 XDH ACOT2;ACOT1 NQO1 ARNT2 GCH1 RANBP9 ORMDL1 PLEKHA6 COX6C KCNS3 PNPLA4 CBR1-1 ACAA2 GDA NDUFA12 COMT COX6A1 COX6A2 AKR7A3 GGT1 CA14 G6PD ACOT12 NOSIP SDHC SDHB SHPK DPEP1 GLYAT HIGD1A ADIPOR2 ATP5MC1 FUT9 DHRS7B MPST EEFSEC HSPA9 ACBD6 IDH1 IDH2 EPHX1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 NMRAL1 COQ6 HIGD2A GLUD1;GLUD2 SEPSECS AMACR CRYL1 MAN2B1 COX20 ABCD3 PODXL2 TAT OPLAH ADAL GAPDH-1 CA1 PLCZ1 CA3 CA2 CA7 AOX1 UQCRFS1 CA6 A4GALT SULT4A1 HIBCH GLRX5 BCKDHB LMBRD1 NDUFS8 DCT THRAP3 CHDH NDUFS3 NDUFS2 LALBA NAT8L B4GALT6 FBP2 PON3 PDXK PTGES3-1 PON2 PON1 LTC4S RMND5B HMGCL MAT2A TGS1 AK4-1 PDSS2 CHSY3 BPNT1 CRYM MBTPS1 RRM1 SGPP2 HS3ST2 CYP11B1;CYP11B2 VDR SLC44A2 PITPNB CPNE6 PLA2G3 PGS1 PTDSS2 GPAT4 PTPMT1 CPNE3 GPAT2 CHKB DGAT2 MBOAT7 STARD10 PLAAT3 GPCPD1 CRLS1 ABHD3-2 HADHA PHOSPHO1 ETNK2 LPCAT4 ETNK1 CSNK2B PNPLA3 CHPT1 CSNK2A1;CSNK2A3 LPIN1 MGLL PLA1A ACAN PRSS3;PRSS2;PRSS1 MED16 MED17 NCOA6 ELOVL5 MED23 MED24 PLIN2 CCNC-1 MORC2 PPARGC1B CIDEC CDK8 FABP4 SCD MED31-1 PDZD11 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 SLC5A6 BTD PC ACACB AKT1 PRKACB-1 PRKAR1A PRKAR2A NUP205 NUP107 NUP85 NUP88 SEC13 NUP133 NMT1 HEXB HYAL3 CSPG5 PPP2R5D PIK3R1 CYP2D6;LOC107987479;LOC107987478-1 RPS15 RPS11 RPS13 SDC3 PIK3R4 ST3GAL4 GPC3 GPC2 GPC4 ST3GAL1 ST3GAL3 RPS25 RPS27 RPS29 FAU RPS21 RPS24 SPHK1 GNA14 GNB2 GNB1 GNB4 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds SULT4A1 GSTK1 COMT GGT1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MAT2A ACSM5 GSTA3;GSTA5;GSTA1;GSTA2 ACSM4 GLYAT MTR-1 BPNT1 UGT2A1 CHAC1 GLYATL3 ABHD10 PODXL2 AHCY OPLAH TRMT112 MGST3 SLC35D2 MGST1 GSTT1 AS3MT SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis TPH1 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes PYCARD P2RX7 AIM2 CASP1 SUGT1 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model SLC25A27 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects FZR1 UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation IARS1 PPA1-1 AIMP1 GARS1 FARSA YARS1 TARS1 VARS1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 HGF RAP1A DOCK7 CRK GAB1 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes AREG ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA BTLA PTPN11 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPS27 RPL35 RPS29 RPL38 RPL39 FAU RPS21 RPS24 RPL22 RPL37A-1 RPS15 RPL18 EEF1G RPS11 RPS13 RPL4 RPL30 RPL29 RPL31 RPL7A RPL6 RPL7 RPS25 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation FGF7 FGF22 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border TCF7L1 ZIC1 MYB POU5F1;POU5F1B CTNNB1 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) AKT2 AKT3 TSC2 AKT1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism IARS1 NQO1 TXNRD1 BCKDK SLC44A2 TMLHE UROC1 CARNS1 NAGS CDO1 RPL18 DMGDH CKM GNMT AGMAT GLYAT MTR-1 GATM CBS;CBSL MPST EEFSEC CRAT SEPHS2 PSMD8 GLUL PSMA6 PSMD12 NMRAL1 PSMD11 GLUD1;GLUD2 RPL37A-1 PSMB1 SEPSECS PSMC2-1 RPS15 PSMA7 DIO1 PIPOX TAT RPS11 RPS13 ALDH7A1 RPL4 RPL30 RPL31 RPL6 RPL7 GLS RPL35 HIBCH RPL38 BCKDHB AMDHD1 RPL39 DCT ASL CHDH SECISBP2 RPL22 NAT8L PYCR2 PYCR3 CKMT1A;CKMT1B SERINC3 SERINC2 ETHE1 AIMP1 SERINC4 AMD1 GADL1 RPL29 IDO2 RPL7A TPH1 CRYM RPS25 RPS27 RPS29 AFMID AUH FAU RPS21 RPS24 INMT OGDH SLC25A10 ASPA AHCY GLS2 PPM1K ENOPH1 HSD17B10 SRM ARG2 SLC25A21 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production KLC2 ITPK1 RACGAP1 MFN1 KIF1C HMG20B MFN2 KIF21B PRKACB-1 SH2B3 RBSN KIF27 KIF18A PRKAR1A KIFC1 PRKAR2A CAPZA1 MAFF CDK5 KIF2C ZFPM2 DOCK1 ZFPM1 DOCK7 HDAC1 MYB KDM1A KIF12 GATA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PHF21A AKAP1 CDC42 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion LIPF PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUCA2A CLPS RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B4 EIF2S2 EIF2S3;EIF2S3B EIF2B1 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation NOS2 VPS33B ATP6V1H CORO1A RAB7A INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling PDCD4 IL12B HSPA9 SNRPA1 IL12A IL12RB1 IL12RB2 TALDO1 CAPZA1 JAK1 CA1 TYK2 SOD2 CFL1 CDC42 HNRNPA2B1 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity BACH1 RBX1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC7A7 SLC7A8 SLC7A11 SLC38A3 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes AJUBA SETD1B MCRS1 CIDEC CDK8 H2BC15;H2BC3;H2BC11;H2BC12 FABP4 TADA2A CDK5 YEATS2 KANSL2 SCD MED31-1 DGAT2 PHF20 AKAP8L PSIP1 MED16 MED17 LPIN1 PHLDA1 MGLL MEN1 BOD1L2;BOD1 NCOA6 ELOVL5 HCFC1 MED23 MED24 PLIN2 CXXC1 CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1B METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors CYB5A MMAB LMBRD1 FOLR2 PANK4 PDXK MTHFD1 PPCS FASN ENPP2 SLC23A2 SLC46A1 NMNAT2 SLC23A1 PRSS3;PRSS2;PRSS1 CD320 MTR-1 PDZD11 SLC22A13 SLC19A3 ALDH1L1 SLC19A1 TCN2 TCN1 SLC52A1;SLC52A2 NUDT12 SLC5A6 SLC25A51;SLC25A52 BTD PC ACACB AOX1 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated MAPK1 PPP2R5D CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response ADAM17 MAPK14 MYH9 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 POLR2L TFDP1 TFDP2 TXNRD1 GTF2H3 GATAD2A CDK5 ERCC3 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53RK USP7 RHNO1 MEAF6 MAPKAP1 MDM2-2 NPM1-2 PCBP4 BCL2L14 CCNA1 PRELID3A BANP BARD1 FANCI MAPK14 PRELID1 CRADD FANCC CNOT6 CNOT7 GLS AKT1 JMY PIN1 CDK12 CNOT9 ATR PIP4K2C RAD9A BTG2 DYRK2 SETD9 PRKAG3 ING5 PIDD1 ING2 EXO1 MLST8 CASP2 ZNF385A RFC5 RFC3 RFC4 SCO2 RFC2 RABGGTA PCNA WRN PERP PLAGL1 RBBP8 RFFL E2F7 E2F8 RPA2 HIPK1 POU4F1 ELL PML COX7C TAF7L TTC5 RPA3 LAMTOR2 POLR2G TAF12 TAF13 TAF11 SSRP1 GTF2F1 GPI PRKAG2 TAF7 TAF5 TAF2 PPP2R5C COX6C COX6A1 COX6A2 G6PD TNRC6A-1 CSNK2B CSNK2A1;CSNK2A3 CCNB1 AKT2 AKT3 CENPJ PHF20 CASP1 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 CCNE1 GLS2 TSC2 RBBP7 JUN CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism CKMT1A;CKMT1B CKM GATM TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes TADA1 SETD1B MCRS1 HMG20B GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 TADA2A YEATS2 KANSL2 EZH2 MEAF6 ING5 PHF20 SUV39H2 KDM5B SAP130 KDM5C SETD3 TRRAP KDM1B SETD7 VPS72 TAF12 RUVBL2 RUVBL1 HCFC1 KMT5B SAP30 PBRM1 KDM2A PRMT7 AEBP2 ARID5B SUPT3H MSL1 HDAC1 BRMS1 KAT6B PADI4 KDM3A KDM3B SAP30L PADI6 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 BRD8 RBBP7 KDM4B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM4D PHF21A USP22 ELP1 ELP6 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules PDZD11 SLC5A6 ARL2BP SLC27A6 SLC35B3 SLC29A4 SLC28A2 SLC27A1 SLC29A3 SLC35D2 SLC35A1 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle DSP TMOD3 TXNL1 PTPN13 SEMA4F TNFAIP1 LEMD3 RND3 CKAP4 KTN1 VANGL2 KCTD13 PKP4 ANKRD26;CCDC144A;LOC105375816 PICALM PIK3R1 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A1 SLC9A2 SLC9A3 SLC9A4 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 KLC2 PKN2 RACGAP1 GOPC MFN1 B9D2 PKN1 MFN2 PTPN13 KIF18A RHOA H2BC15;H2BC3;H2BC11;H2BC12 KIF2C DOCK1 DDX39B MTR-1 RAB7A CFL1 S100A9 MYH9 CTNNB1 MAPK1 MAPK14 PIN1 NUP107 NUP85 SEC13 NUP133 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C AR CDC37 ERBIN DSP TMOD3 TXNL1 SEMA4F TNFAIP1 LEMD3 RND3 JAG1 CKAP4 KTN1 VANGL2 KCTD13 PKP4 ANKRD26;CCDC144A;LOC105375816 PICALM CPNE8 PLXND1 PRAG1 FAM13B WIPF3 FRS2 FAM13A PIK3R1 ARHGDIG SYDE2 PREX2 GOLGA3 PREX1 ARHGAP42 BAIAP2L1 OPHN1 PRKCB FNBP1 PPP1CC TPM3 ACTN1 DYNC1I2 CYBB CYBA TEX2 BCR ALDH3A2 DAAM1 SPATA13 BTK ABCD3 STAM2 RHOBTB3 ARHGAP17 ARHGAP15 DYNC1H1 IQGAP2 IQGAP3 SKA1 SKA2 ARHGAP22 MYO6 STK38 PLXNA1 ABL2 NCKAP1L SRGAP2 MYH10 SRGAP1 SCAI MCAM ARPC4 PTK2 DIAPH2 DIAPH3 NOXA1 NDUFS3 PIK3R4 NOX3 ACTR3-1 NF2 MAP3K11 ACTC1;ACTG2 AHCTF1 RASGRF2 C1QBP NUF2 EFHD2 SPTAN1 EMD GIT1 ARHGEF11 ACTR2 NUDC PLEKHG1 ARHGEF15 ATP6AP1 CCDC115 ARHGEF17 ARAP2 RPS27 RHOF LBR RHOD NIPSNAP2 SENP1 CDC42EP1 EVL PKN3 MEN1 WAS FAM169A CENPA NSL1 SH3BP1 SLITRK3 NHS DOCK7 EMC3 SLITRK5 STOM FLNA CSK RBBP6 WASF2 WASF3 CCNE1 FARP1 USP9X CDC42BPA MYO9A KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF ABI2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI CCT7 TAOK1 CENPM CDC42 RAB9A DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells SNW1 HDAC5 KLF13 IL12RB2 CBX4 MAMLD1 SATB1 MEN1 IL13 GATAD2A BMI1 PHC3 TNF BATF YY1 MAF CCL3L1;CCL3L3;CCL3;CCL18 HDAC1 RBBP7 JUN NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration IDH1 ACO1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine NAGK AMDHD2 GFPT1 RENBP TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling TBK1 RIPK1 TRAF2 SHARPIN MIB2 BIRC2 TNFRSF1A BIRC3 TNF FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex HDAC1 TCF7L1 TRRAP MEN1 AXIN2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RUVBL1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CTNNB1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP6 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome BTRC PSMD8 PSMA6 RBX1 PRKACB-1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TBK1 TLR4 LY96 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi ST3GAL4 MGAT4B ST6GAL1 MGAT4A-1 MGAT3 B4GALT6 MGAT5 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation PPP2R5D UBE2V1 TAB2 NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC RIPK2 MAPK14 MEF2C MAP3K8 JUN GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway SNW1 TFDP1 TFDP2 MAMLD1 ZFPM1 SOD2 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BDNF GCK TP53RK USP7 RHNO1 MEAF6 MAPKAP1 MAPK1 MDM2-2 NPM1-2 PCBP4 BCL2L14 CCNA1 PRELID3A BANP BARD1 FANCI PRELID1 CRADD FANCC CNOT6 CNOT7 GLS JMY PIN1 CDK12 CNOT9 ATR PIP4K2C RAD9A BTG2 DYRK2 SETD9 PRKAG3 ING5 PIDD1 ING2 EXO1 MLST8 MED8 CASP2 ZNF385A RFC5 RFC3 RFC4 SCO2 RFC2 RABGGTA PCNA WRN PERP PLAGL1 RBBP8 RFFL E2F7 E2F8 RPA2 HIPK1 POU4F1 PML TTC5 RPA3 LAMTOR2 KDM5B PBRM1 GPI PRKAG2 AR SUMO1 VDR RARA NR3C1 KIT CSNK2B CSNK2A1;CSNK2A3 PRKCB EGFR CCNB1 CENPJ ESRRA G6PC1 PHF20 LBR MED16 MED17 MEN1 ARNT MED23 MED24 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GLS2 USP9X H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZNF324B;ZNF324 PPARGC1B POLR2L ZNF382 SETD1B ZNF669;ZNF670 HDAC5 GTF2H3 TXNRD1 CBX4 GATAD2A BMI1 CDK8 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 YY1 MAF CDK5 ERCC3 MED31-1 EZH2 MEF2C ZNF605 ZNF555;ZNF57;ZNF556 ZNF713 ZNF157 ZNF398 TWIST2 ZNF707 PSMD8 NKX2-5 UCMA PSMA6 CTLA4 ZNF248 PSMD12 TEAD2 PSMD11 TEAD3 TEAD4 ZNF599 PSMB1 ZNF473 CTNNB1 PSMC2-1 SERPINB13 SATB2 PSMA7 ZNF557;ZNF558 NPY ZNF226 ZNF583 CDKN2B PCGF2 ATAD2 RYBP CAMK4 MAPK14 AGRP ZNF697 ZFP28 ZNF573 CSF2 AKT1 ZNF274;ZNF74 ZFP30 ZNF567 ZNF445 PITX2 ZNF202 ZNF160;ZNF347;ZNF665-1 MSX2 LIFR RBX1 FOXP3 APOE NRBP1 PCK1 ITCH PVALB ZNF793 ZNF791 KRBA1 ZNF546 ZKSCAN5 ZNF664 ZFHX3 SMAD4 AUTS2 ESRRB IL2 CDK6 ZNF426-1 ZNF771 LDB1 DGCR8 MYBL2 ZNF641 RBM14 ZNF75A CAMK2B ELL CAMK2D COX7C TAF7L CAMK2A INS;INS-IGF2 ZNF746 E2F6 CAMK2G ZNF740 POLR2G ZNF747;ZNF764 ZNF184 KCNIP3 MGA TBX5 TAF12 ZNF614 TAF13 TAF11 SSRP1 GTF2F1 TAF7 TAF5 TAF2 ARNT2 PPP2R5C COX6C JAG1 COX6A1 COX6A2 HNF4A G6PD TNRC6A-1 BRD2 KCTD1 KCTD15 FZR1 UBE2C CDKN2A CDC26 ANAPC1 ANAPC10 ANAPC11 AKT2 AKT3 IRAK1 PTPN11 CASP1 TCF7L1 CCNE1 MYB TSC2 GATA1 NOTCH3 JUN COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis HSPA9 NDUFA7 NDUFS8 NDUFA3 NDUFS3 NDUFS2 NDUFA12 NDUFB8 NDUFB6 ECSIT TMEM186 NDUFAF2 NDUFB4 NDUFB2 NDUFAF1 NDUFB1 LYRM2 HSCB PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CRTC1 CRY1 TFEB TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion HSD17B10 TRMT10C PRORP COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway SDC3 FGB FGA GPC3 PF4;PF4V1-1 SERPINE2 GPC2 F10 F12 GPC4 F11 FGG F2 F9 SMPD1 ANO6 KLKB1 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling SLC25A27 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle POLR2L GTF2H3 ERCC3 NUP205 NUP107 TSG101 ELL TAF7L NUP85 MVB12A RCC1 NUP88 POLR2G SEC13 PDCD6IP NUP133 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CHMP2B NMT1 UBAP1 GTF2H2C;GTF2H2C_2;GTF2H2 CHMP3 TAF7 TAF5 CHMP6 TAF2 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins PIAS3 SUMO1 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage ADAL AMPD2 AMPD3 ADA CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKACB-1 PRKAR1A PRKAR2A DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins ADAMTS20 MUC1 ADAMTSL5 THSD7A MUC4 MUC21 ADAMTS1 SEMA5A MUC5B CFP THBS2 NOTCH3 THSD4 ADAMTS10 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication POLR2L RPL35 RPL38 RPL39 RPL22 RPL18 RPL29 RPL7A NUP205 NUP107 RPS25 RPS27 NUP85 RPS29 NUP88 POLR2G SEC13 FAU NUP133 RPS21 RPS24 RPL37A-1 GTF2F1 RPS15 RPS11 RPS13 RPL4 RPL30 RPL31 RPL6 RPL7 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures WRN MUS81 RTEL1 BARD1 EME1-1 EME2 RBBP8 PALB2 SLX1A;SLX1B EXO1 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action IFIT3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) UBAP1 MVB12A CHMP3 STAM2 CHMP6 VPS25 TSG101 CHMP2B ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP8A1 TCIRG1 ATP12A TSC22D3 ATP11B ATP1B1 SLC9B2 SCNN1G SCNN1D SCNN1B ATP6V0D2 ATP6V1A TRPC6 TTYH2 ATP6V1H ATP1A1 TRPV6 CLCN3 TRPV4 CLCN2 TRPM8 CLCN1 TRPM4 ASIC4 PDZD11 BSND CLCA1 ATP6V0A4 SGK3;C8orf44-SGK3 ASIC2 ATP9B ASIC3 ATP6V1F ATP8B3 ATP13A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 TPCN2 TPCN1 CLCN7 ATP4B CLCN6 ATP4A CLCN5 CLCN4 ANO6 ATP6AP1 CAMK2B CAMK2D CAMK2A CAMK2G ATP2B2 ATP2B1 STOM TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) RHOA TGFBR1-1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection PLCG2 PRKACB-1 PRKAR1A MYH9 PRKAR2A GGT1 GNAZ CD3G AHCYL1 CYSLTR1 ADAM17 GNB2 MAPK14 DPEP1 GNB1 GNB4 GNAI2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 MAPK1 CBL PTPN11 FRS2 PIK3R1 GAB1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation TLR7 PPP2R5D TRAF2 UBE2V1 TLR4 TAB2 NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MEF2C MYD88 MAP3K8 JUN LY96 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation FGF22 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism LPIN1 MGLL PRKACB-1 PPP1CC PNPLA4 FABP4 GPAT2 DGAT2 MOGAT3 MOGAT1 FABP3 ABHD5 FABP5 FABP6 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism GLUL ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein SUMO1 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism AACS HMGCL RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs IQGAP2 IQGAP3 MEN1 CTNNB1 CDC42 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B CALHM1 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation ST3GAL4 MGAT4B ST6GAL1 MGAT4A-1 B4GALT6 MGAT5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 NUP88 SEC13 NUP133 NUP205 CCNB2 NUP107 NEK9 CCNB1 NEK6 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A AKT2 AKT3 AKT1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry GPC3 GPC2 GPC4 SDC3 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling MAPK1 AREG AKT2 AKT3 PTK2 EGFR AKT1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism NDST3 HPSE GPC3 HS3ST2 GPC2 GPC4 SDC3 GLCE SLC35D2 HS6ST2 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis TBC1D8B RAB5C SORT1 HIP1R ARRB1 AP3B1 TPD52L1 BLOC1S4 BLOC1S1 DNAJC6 FTH1 BLOC1S3 AP1S3 PICALM THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DIO1 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 SFTPD CSF2RA RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes CEP63 DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBGCP5 TUBGCP6 TUBA1A TUBGCP4 CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling AKT2 BTK AKT3 GNB2 PIK3CG GNB1 RHOA GNB4 AKT1 PIK3R5 CDC42 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling MAPK1 IRS2 PRLR ADAM17 IRS1 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis COQ8A COQ6 PDSS2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling RHOA VANGL2 PRICKLE1 PPP3CB GNAT2 PDE6B PDE6A WNT5B FZD4 FZD7 WNT5A FZD6 TNRC6A-1 CAMK2A PSMD8 PRKCB PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 DAAM1 TCF7L1 GNB2 GNB1 AP2A1 GNB4 AP2A2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation MYO6 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) IL12RB2 TNF CCL3L1;CCL3L3;CCL3;CCL18 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease BCKDHB PPM1K NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants ALK P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 ZNF385A PSMA7 MDM2-2 PCBP4 CCNA1 CCNE1 COP1 PHF20 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport IFT81 DYNLT2B IFT140 IFT122 IFT52 TTC26 IFT43 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R5E REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha ARNT2 TXNRD1 MTF1 THRAP3 CDK8 ESRRA MED28-1 MED8 MED31-1 FHL2 TGS1 ME1 MED16 MED17 SLC27A1 APOA2 CPT1A APOA1 ARNT NCOA6 FADS1 MED23 MED24 PLIN2 TRIB3 CCNC-1 CYP7A1 PPARGC1B ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets MAPK1 PPP2R5D MAPK14 MEF2C DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions LGI2 ADAM23 ADAM11 CACNG3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism BTD PC ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation FBXL19 KLHL2 FBXL16 FBXL14 KLHL20 SPSB2 SPSB1 UBOX5 MKRN1 ASB7 BLMH TRIM37 RNF220 MIB2 FZR1 PSMD8 CDC34 UBE2C PSMA6 UBE2D3;UBE2D2 CDC26 ANAPC1 PSMD12 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 BTRC UBE2V1 RBX1 ITCH UBE2D4 FBXO21 DCAF1 HERC2 TRIM21 UNKL FBXO7 FBXW8 KCTD7 RNF126 FBXW4 RNF138-1 UBE2R2 RNF213-2 UBA6 RBBP6 RNF6 RCHY1 ASB16 UBE2J1 FBXL20 HECTD1 UBA7 BTBD1 HECTD3 LONRF1 UBE2B KLHL25 RNF25 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors DRD4 DRD5 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin MAOA ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis FBXW4 SPHK1 AP3M1 CCNE1 XRN2 KIF13A CCT7 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion GNB2 GNB1 ADRA2A GNB4 GNAI2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death RIPK1 TRAF2 H2BC15;H2BC3;H2BC11;H2BC12 CDK5 GOLGA2 POLA2 C1QBP GSDME EZH2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SOD2 JUN FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism ELOVL6 PTGR2 ACOT9 HACL1 MECR CBR1-1 ACAA2 DECR2 PON3 PTGES3-1 GGT1 PON2 SCD FASN PON1 LTC4S ACOT12 ACSL3 HACD1 DPEP1 HADHA TECR CRAT PTGDS ACBD6 SLC27A1 FADS2 CPT1A CYP4F3;CYP4F2;CYP4F12;CYP4F11 ELOVL5 PPT1 AMACR SLC25A17 FADS1 PRKAG2 ACLY HSD17B4 MCEE PHYH-4 ELOVL1 MORC2 ACOT2;ACOT1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors CAMK2A MDM2-2 CAMK2G CACNG3 PRKCB AKAP5 MYO6 AP2A1 CAMK2B CAMK2D ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 POLR2L POLR2G CBL GTF2F1 GAB1 MAPK1 ESRP1 FGF7 HNRNPA1-1 FGF22 PTPN11 FRS2 PIK3R1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 MDM2-2 EPS15 PSMD8 PSMA6 BANP PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis PLCG2 ARPC4 PTK2 WAS ACTR3-1 MYH9 NF2 CRK DOCK1 MAPK1 BTK WASF2 MYO10 CD3G WASF3 AHCYL1 MYO5A ACTR2 ABI2 WIPF3 PIK3R1 CFL1 CDC42 NCKAP1L FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope IVL DSP PKP4 PERP KLK5 KLK14 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 LIPJ LIPN PKP1 SPINK9 LIPK APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response MAPK1 GSDMD C1QBP GSDME CASP3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase PDE11A PDE10A PDE1A KCNMB1 KCNMB4 NOS2 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere POLR2L POLR2G ATRX TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling HGF PIK3R1 GAB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 UBE2C SEC13 CDC26 PPP1CC NUP133 ANAPC1 DYNC1I2 CENPA ANAPC10 NSL1 ANAPC11 DYNC1H1 SKA1 SKA2 CENPF CENPI TAOK1 CENPM PPP2R5E NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals DCC UNC5C PTPN11 PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy EPAS1 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism TAT SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction MPP5 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants FLT3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPS27 RPL35 RPS29 RPL38 RPL39 UBE2D3;UBE2D2 FAU RPS21 RPS24 RPL22 RPL37A-1 ASCC2 RPS15 RPL18 RPS11 RPS13 RPL4 RPL30 RPL29 RPL31 RPL7A RPL6 RPL7 RPS25 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity PREX2 CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 MKRN1 PSMD11 PSMB1 PSMC2-1 RNF146 PSMA7 FRK AKT2 AKT3 AKT1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs CAMKK2 GIT1 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection ARPC4 PTK2 PRKACB-1 NOXA1 PRKAR1A ACTR3-1 PRKAR2A CRK DOCK1 CTSG GGT1 MYO10 AHCYL1 MYO5A ADAM17 ACTR2 DPEP1 FZD7 WNT5A WIPF3 GSDMD PYCARD PLCG2 P2RX7 CASP1 WAS SUGT1 CYBA MYH9 MAPK1 C3AR1 BTK P2RX4 GNAZ WASF2 CD3G WASF3 CYSLTR1 GNB2 MAPK14 GNB1 ABI2 GNB4 GNAI2 CDC42 NCKAP1L JUN SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism NEU3 ST3GAL4 ST6GALNAC5 NEU1 GNE ST3GAL6 ST6GALNAC3 ST6GAL1 ST3GAL1 ST3GAL3 CTSA SLC35A1 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling HDAC1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) CNOT9 KDM5B H2BC15;H2BC3;H2BC11;H2BC12 TEAD4 DICER1 ZFP36L2 PABPC1;PABPC3 DPPA4 TPRX1;RAX2 PABPN1-1 DUX4;DUXA H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 EIF4E EIF4B CNOT6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CNOT7 SRPK1 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission LIN7C NRGN GABRR3 CHRND GABRR2 GABRR1 GLRA3 PRKAG3 PRKACB-1 KCNJ3 KCNJ5 GABBR2 KCNJ10 GABRA4 PRKAR1A PRKAR2A KCNJ15 GRIN3B GRIN3A GLRB RASGRF2 LRRC7 GIT1 CAMK2B CAMK2D CAMK2A CAMK2G CACNG3 PRKCB CHRNB2 CAMKK2 MAPK1 MDM2-2 PRKAG2 GNB2 CAMK4 AKAP5 GNB1 MYO6 GABRB3 AP2A1 GNB4 GRIK5 GNAI2 CHRNA9 GRIK4 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development SNW1 INS;INS-IGF2 MAMLD1 GCK PDX1 AKT2 MAFA AKT3 NEUROD1 PTF1A FOXA2 NKX2-2 AKT1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis POLA2 GSDME EZH2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium CEP63 IFT140 B9D2 IFT122 IFT52 SMO ARL6 PKD2 MCHR1 TCTN3 BBS7 EXOC7 SCLT1 TTC26 KIF24 RAB11A IFT43 AHI1 IFT81 DYNLT2B DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide TCF25 RPL35 RPL38 RPL39 PSMD8 UBE2D3;UBE2D2 RBX1 PSMA6 PSMD12 PSMD11 RPL22 PSMB1 RPL37A-1 PSMC2-1 PSMA7 RPL18 RPL4 RCHY1 RPL30 RPL29 RPL31 RPL7A RPL6 RPL7 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism LMBRD1 MMAB PRSS3;PRSS2;PRSS1 TCN2 TCN1 CD320 MTR-1 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members SNW1 TFDP1 TFDP2 ARRB1 RARA CBL CDK8 RHOA SMAD4 MTMR4 TNRC6A-1 PPP1R15A USP15 BMPR2 PSEN2 ACVR1B APH1A MEN1 PPP1CC ITGAV AMH CER1 PSENEN MYOG TGFBR1-1 TGFB2 SMAD5 MYOD1 MAPK1 STRAP BMPR1B BMPR1A HDAC1 CDKN2B CCNC-1 USP9X PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NPM1-2 MYBL2 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily SUMO1 GATAD2A PCK1 H2BC15;H2BC3;H2BC11;H2BC12 G6PC1 TCF19 HDAC1 PWWP2B IKZF1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 ZMYND8-1 PWWP2A ADNP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression POLR2L POLR2G H2BC15;H2BC3;H2BC11;H2BC12 YY1 GTF2F1 PTGES3-1 HDAC1 MYB KDM1A SMC3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KDM4B STAG2 NRIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TFF1 TNRC6A-1 FKBP4 JUN SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHA TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling TEK PTPN11 PIK3R1 ANGPT4 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT9 DICER1 ZFP36L2 PABPC1;PABPC3 EIF4E EIF4B CNOT6 CNOT7 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex CCNA1 CCNB1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) COPS7B XPC COPS7A MCRS1 POLD4 PIAS3 RFC1 GTF2H3 SUMO1 PARP2 RBX1 RAD23A RAD23B DDB1 COPS8 YY1 RFC5 ERCC3 RFC3 RFC4 RFC2 PCNA RPA2 RPA3 RUVBL1 GTF2H2C;GTF2H2C_2;GTF2H2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance APOB AP2A1 AP2A2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRND CHRNA9 CHRNB2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation MAPK1 INS;INS-IGF2 IRS2 IRS1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria NMT1 GZMH;GZMB-1 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling JAK1 SUMO1 PTPN11 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism SGPP2 ACER3 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs RPL35 RPL38 RPL39 RBX1 MSI1 RPL22 GSPT1 SLIT1 HOXA2 LHX2 RPL18 COL4A5 ETF1 RPL29 LDB1 RPL7A RPS25 RPS27 RPS29 PSMD8 PSMA6 FAU PSMD12 RPS21 PSMD11 RPS24 PSMB1 RPL37A-1 PSMC2-1 PSMA7 RPS15 RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes AJUBA MED16 MED17 LPIN1 PHLDA1 MGLL CIDEC CDK8 NCOA6 H2BC15;H2BC3;H2BC11;H2BC12 ELOVL5 FABP4 MED23 CDK5 MED24 PLIN2 SCD MED31-1 DGAT2 CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1B DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS27 RPS29 FAU RPS21 RPS24 RPS15 EIF3C;EIF3CL RPS11 EIF3L RPS13 EIF4EBP1 PABPC1;PABPC3 EIF2S2 EIF3E EIF2S3;EIF2S3B EIF3B EIF4E EIF4B RPS25 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing NTHL1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events CAMK2A CAMK2G PDE1A PLCB4 PRKACB-1 PRKAR1A PRKAR2A CAMKK2 MAPK1 GNA14 AHCYL1 CAMK4 CAMK2B CAMK2D SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IP6K2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane INPP5F MTM1 PI4K2B PIK3R4 MTMR4 INPP4A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin F2 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation PPIB PLEC COL17A1 COL18A1 COL15A1 COL12A1 MMP20 MMP7 COL4A5 MMP9 ITGB4 BMP1 LOXL3 LOXL1 COL4A4 PXDN TLL1 SERPINH1 COL6A3 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle LIN7C TSPOAP1 RIMS1 PPFIA4 CPLX1 PPFIA3 PPFIA2 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CAMK4 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) EDEM3 RNF103 RNF139 TRIM13 EDEM2 SYVN1 UGGT2 UGGT1 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation SMAD4 POU5F1;POU5F1B CTNNB1 NANOG;NANOGP8 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling PPP2R5B PPP2R5A PPP2R5D PPP2R5C HDAC5 CBX4 GATAD2A MKRN1 BMI1 PHC3 KIT EZH2 IRS1 FRS2 PIK3R1 TNRC6A-1 PREX2 CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 BDNF PSMD12 EGFR PSMD11 FLT3 PSMB1 USP7 PSMC2-1 RNF146 KLB PSMA7 FRK IER3 MAPKAP1 MAPK1 AKT2 AKT1S1 MDM2-2 AKT3 PHLPP1 TRIB3 IL33 EGR1 FGF19 SNAI1 STRN MYD88 AKT1 PIK3R5 PIP4K2C MLST8 IRAK1 IRS2 PIK3CG PTPN11 PML INS;INS-IGF2 LAMTOR2 HGF GAB1 AREG FGF7 HDAC1 FGF22 TSC2 KDM1A RBBP7 PPP2R5E JUN REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis FAS GSDMD RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CDC37 CASP1 PDCD6IP ITCH GZMH;GZMB-1 CASP3 CHMP2B GSDME CHMP3 CHMP6 BIRC2 BIRC3 PELI1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events RASGRF2 BTK PREX1 ARHGEF11 GNB2 GNB1 RHOA ARHGEF15 GNB4 ARHGEF17 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease SNW1 TFDP1 TFDP2 E2F3 MAMLD1 CBL SFPQ-1 CRK GOLGA2 DOCK1 POLA2 GSDME FASN ESRP1 HNRNPA1-1 EPS15 MYO10 MYO5A DHX38 LY96 GSDMD RIPK1 TRAF2 TLR4 UBE2D3;UBE2D2 BDNF ATRX GCK FLT3 TGFBR1-1 RAP1A MAP2K2;MAP2K1 MAPK1 C3AR1 P2RX4 GNE RPL4 RPL30 RPL31 PABPN1-1 ENO1 EIF4E RPL6 RPL7 RPL35 RPL38 RPL39 RPL22 MED8 NHLRC1 RPL29 GNS PLCG2 PSEN2 APH1A TCN2 PSENEN ADA FKBP4 GZMH;GZMB-1 MED28-1 RPL18 NTHL1 PPIB PPP1CC SYVN1 RPL37A-1 KLB AKT1S1 FGF19 STRN HNRNPR CLDN1 SLC26A2 FGFR1OP2 DKK1 BIN2 TYRO3 ABCB6 CTBP1 ZC3HAV1 RDH12 GRPEL1 ICOS JAG2 KPNA4-1 ERLIN1 ERLIN2 SLC6A5 SLC6A2 PQBP1 APBB1IP MRAS ISY1;ISY1-RAB43 G6PC1 SF3B6 EPCAM BRD4 XAB2 NUDT21 PHF5A HHAT SNRPN S100A1 LY6E BAG2 PIK3CG CHERP EIF4G3 RPL7A FOXM1 DUSP10 CTNNBL1 SIGMAR1 KSR2 SLC37A4 UNC93B1 PUF60 PGM1 E2F2 DNAJA2 PPIL4 PRF1 GCC2 APOA1 KDR SLC12A6 SRRM2 ALG8 IL1R1 ALG3 COG1 CTR9 SEC31A BCL11A SUGP1 HIP1 SH3KBP1 SLC22A12 ZMYM2 PCF11 SLC22A18 CHMP1A AVPR1B PPM1K KREMEN1 AGTRAP MAPRE3 SLC20A2 MIB1 PPIL1-1 SLC5A1-1 WBP11 DHDDS PRPF6 MMAB PPIH TXNRD1 PPIG RTN3 PRPF8 SYT2 BCKDK FGFR3 SLC40A1 CGAS ELAVL2 GBP2;GBP3;GBP1 NAGS HEPH BLNK DYNLT1 BUD31 BCL2A1 DCTN1 SV2A HES5 AHCYL1 CD9 MTR-1 GALM-2 TALDO1 PPP1R3C MAOA PIK3R5 NEU1 ASL CTSA CD320 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 AUH GAA CYP7B1 AHCY GNAI2 COMT GGT1 DPEP1 IDH1 NMRAL1 OPLAH HIBCH BCKDHB LMBRD1 PTGES3-1 CYP11B1;CYP11B2 PYCARD P2RX7 CASP1 SUGT1 HGF GAB1 AREG EEF1G FGF7 FGF22 TSC2 KDM1A PHF21A CDC42 HMG20B NOS2 ATP6V1H CORO1A RAB7A SOD2 HNRNPA2B1 SNRPA1 SLC7A7 MYH9 RHNO1 MAPKAP1 MDM2-2 NPM1-2 BARD1 ATR RAD9A EXO1 MLST8 RFC5 RFC3 RFC4 RFC2 WRN RBBP8 RPA2 PML RPA3 BRMS1 SLC29A3 SUMO1 NR3C1 KIT WIPF3 CSNK2B CSNK2A1;CSNK2A3 EGFR TPM3 DYNC1I2 CYBA BCR CCNB1 BTK BTRC STAM2 DYNC1H1 NCKAP1L ARPC4 PTK2 NOXA1 ACAN ACTR3-1 ADAMTS1 MAP3K11 CTSG C1QBP MMP9 ADAM17 ACTR2 KLKB1 PSIP1 MED16 MED17 WAS SAP30 MED23 MED24 GTF2H2C;GTF2H2C_2;GTF2H2 CSK HDAC1 WASF2 WASF3 CCNC-1 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ABI2 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TAOK1 POLR2L HDAC5 GTF2H3 GATAD2A CDK8 H2BC15;H2BC3;H2BC11;H2BC12 CDK5 ERCC3 GFPT1 MED31-1 MIB2 EZH2 S100A9 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 BTD PC PABPC1;PABPC3 CAMK4 MAPK14 AKT1 RBX1 PRKACB-1 NRBP1 ITCH PRKAR1A PRKAR2A SLC35A1 SMAD4 CDK6 SPRED3 SPRED2 SPRED1 NF1 NUP205 NUP107 TSG101 CAMK2B ELL CAMK2D TAF7L CAMK2A NUP85 MVB12A RCC1 CAMK2G NUP88 POLR2G SEC13 PDCD6IP NUP133 XRCC4 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CHMP2B NMT1 FGB UBAP1 FGA CHMP3 TAF7 F10 TAF5 F12 CHMP6 F11 TAF2 HEXB FGG F2 F9 CSPG5 SEMA5A UBA7 DDX58 MUC5B CFP AP2A1 AP2A2 THBS2 THSD4 ADAMTS10 PPP2R5E ADAMTS20 PPP2R5B PPP2R5A MUC1 ADAMTSL5 PPP2R5D THSD7A PPP2R5C CDC37 MUC4 ERBIN MUC21 PHB PALB2 SLC17A8 IFIT3 VPS25 JAG1 ATP1B1 ALK IRS1 ATP1A1 FRS2 PIK3R1 FZR1 UBE2C CDKN2A CDC26 ANAPC1 ANAPC10 ANAPC11 ATP1B3-1 FXYD2;FXYD6-FXYD2 MGAT4A-1 GEMIN2 MAGT1 ZDHHC3 RPS15 TBK1 CLCN6 AKT2 AKT3 RPS11 RPS13 GNAZ JAK1 CD3G CYSLTR1 ST6GAL1 RIPK2 OPN1SW VPS33A VPS33B SFTPD ANO6 MYD88 GOLGA7-1 TYK2 TUFM TMEM258 DAD1 RAB5C TLR7 UBE2V1 SNRPF ARRB1 MASP1 ST6GALNAC3 AP3B1 ISCU RPN2 SDC3 RPN1 PIK3R4 DDX20 AP1S3 NOD1 GANAB CSF2RA IRAK1 MGAT5 ST3GAL4 IRS2 GPC3 VPS11 GPC2 SNRPE-2 GPC4 SNRPG-2 ST3GAL1 ST3GAL3 VPS16 FZD4 FZD7 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 WNT5A FZD6 PTPN11 MPP5 SRPK1 RPS25 RPS27 ZDHHC9 RPS29 MGAT4B IL17F TAB2 FAU STT3B RPS21 RPS24 IL17A RNF213-2 UBA6 CCNE1 GNB2 GNB1 GNB4 NOTCH3 JUN SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery RPS27 RPS29 SNRPF FAU RPS21 RPS24 DDX20 GEMIN2 RPS15 RPS11 SNRPE-2 RPS13 SNRPG-2 RPS25 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids HSD17B4 DECR2 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease KDR STRN BIN2 PIK3R1 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 FGF22 PTPN11 FRS2 PIK3R1 GAB1 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor INS;INS-IGF2 ATP6V0A4 ATP6V1F PIK3R4 FLT3 KLB GAB1 TCIRG1 MAPK1 IRS2 AKT2 FGF7 TRIB3 FGF22 FGF19 PDE3B ATP6V0D2 ATP6V1A IRS1 ATP6V1H ATP6AP1 PTPN11 FRS2 PIK3R1 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly SERPINB1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis FABP6 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs NUDT21 PCF11 PABPN1-1 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation PRKCB SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins FGB FGA PTK2 FGG APBB1IP RAP1A CRK DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport PRKACB-1 GNB2 MYO5B GNB1 AQP6 PRKAR1A PRKAR2A GNB4 RAB11A CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A6 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus JAG2 ARRB1 MIB2 PSEN2 APH1A ADAM17 ITCH PSENEN JAG1 MIB1 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation MRPS17 MRPS16 MRPS33 MRPL18 MRPL19 MRPS31 MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 CHCHD1 MRPS28 PTCD3 TSFM MRPS23 MRPL49 MRPS2 MRPL47 MRPS7 MRPL43 MRPL21 LOC107987373;MRPL23 MRPL52 TUFM AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMD8 PSMA6 PABPC1;PABPC3 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 RFC3 RFC4 RPA3 MAD2L2 RFC2 REV1 PCNA RFC1 RPA2 RFC5 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors APOB MSR1 MASP1 SCARA5 SCGB3A2 APOA1 HSP90B1 APOE FTH1 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System AREG AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MDM2-2 AKT2 AKT1S1 AKT3 MKRN1 TSC2 AKT1 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib CDC37 ERBIN APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection PSIP1 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly HSPA9 UQCRC2 SMIM4 C12orf73 BCS1L LYRM4 UQCRFS1 HSCB SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer CDC37 ERBIN EGFR PIK3R1 GAB1 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria GSDMD GSDME INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade GPC3 GPC2 F10 GPC4 SDC3 F2 F9 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis GSDMD GSDME CHMP3 CHMP6 CASP1 GZMH;GZMB-1 CASP3 CHMP2B REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V1A ATP6V1H ASAH1 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins UBE2D3;UBE2D2 H2BC15;H2BC3;H2BC11;H2BC12 CTR9 PCNA PRKDC PEX12 RNF40 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RNF144A TMEM129 UBE2B RNF152 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion INMT EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL35 RPL38 RPL39 RPL22 GSPT1 RPL18 ETF1 RPL29 RPL7A RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 TRMT112 RPL31 RPL6 RPL7 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling CHAC1 GGT1 OPLAH ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling JAK1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation EPCAM FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism SFTPD CSF2RA MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression MTF1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility EGFR RHOA MEMO1 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer CDC37 EGFR CBL PIK3R1 GAB1 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) SV2A DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA POLR2L SNW1 WBP11 PRPF6 PPIH PPIG PRPF8 BUD31 HNRNPA1-1 DDX39B THOC1 DHX38 THOC3 THOC6 HNRNPA2B1 SNRPA1 HNRNPR PABPN1-1 EIF4E NSRP1-1 PPWD1 PNN RBMX2 SNRNP35 SNRPF METTL3 PRPF4B PRPF40A CXorf56-1 PRPF18 PRPF3 PQBP1 C9orf78 SNRNP27 SNRNP25 SNRPC ISY1;ISY1-RAB43 CACTIN SF3B6 CWF19L2 DHX35 SRSF10 XAB2 PRPF38A NUDT21 PPIL2 PHF5A SNRPE-2 CCDC12 SNRPN LSM2 SNRPG-2 LSM8 CHERP NUP205 NUP107 CTNNBL1 PUF60 NUP85 NUP88 PPIL4 POLR2G SEC13 NUP133 SRRM2 GTF2F1 SUGP1 RBBP6 PCF11 XRN2 PPIL1-1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity PRKAG2 ADIPOR2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 MUC1 MUC4 MUC21 MUC5B RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking RAB5C RAB14 GDI1 RAB1B GABARAP GGA3 TBC1D13 TRAPPC11 RAB7A TBC1D10B DENND2D GABARAPL2 RAB11A ANKRD27 DENND4B DENND2B TRAPPC4 TRAPPC10 RAB27A TRAPPC8 RAB11B TRAPPC6A TRAPPC6B RAB13 TBC1D24 RAB38 DENND6B DENND6A RIN2 AKT2 AKT3 TSC2 AKT1 RAB9A HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation PTGES3-1 RPA3 RPA2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly PLEC COL17A1 ITGB4 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway TUBA1A TUBB2B;TUBB2A TUBAL3 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis TDRKH-1 POLR2L MYBL1 POLR2G TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity MAPK1 IARS1 AKT3 ALX3 AIMP1 HDAC1 MITF KIT SUMO1 ZIC1 TFEB CTNNB1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin PSMD8 UBE2C PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins PLEC MAPT SPTAN1 CLSPN DSP BIRC2 PTK2 SATB1 PKP1 CTNNB1 CASP3 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRND CHRNB2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA EXOSC2 EXOSC1 DIS3 MAPK14 EXOSC6 EXOSC4 EXOSC9 EXOSC8 AKT1 DCP2-1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC13 ERAP1 PIK3R4 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SEC31A REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation MAPKAP1 MDM2-2 AKT2 AKT3 PPP2R5C CCNA1 RFFL MLST8 USP7 AKT1 PHF20 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TKT TALDO1 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer MAPKAP1 MDM2-2 AKT2 AKT1S1 AKT3 TSC2 MLST8 AKT1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes GGT1 CYP11B1;CYP11B2 AHCY OPLAH MAOA CYP7B1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) KDM5B H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation TNRC6A-1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 PRKCB FZD4 WNT5A AP2A1 AP2A2 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation POLR2L POLR3A POLR3D POLR3F POLR3K BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis RPA3 ATR TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 RBBP8 SMC3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SUN1 STAG2 RPA2 MLH3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 REC8 SMC1B STAG3 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway PSMD8 PRKCB PSMA6 PSMD12 PSMD11 RHOA PSMB1 PSMC2-1 PSMA7 VANGL2 DAAM1 PRICKLE1 WNT5B FZD4 FZD7 WNT5A FZD6 AP2A1 AP2A2 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 CDC37 ERBIN RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IL2 CTLA4 FOXP3 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants FLT3 PTPN11 PIK3R1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer SMAD4 TGFBR1-1 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHA MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands HDAC1 BDNF NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay YTHDC1 EXOSC2 ZC3H4 EXOSC1 ZC3H18 DXO MPHOSPH6 DIS3 XRN2 PABPN1-1 EXOSC6 EXOSC4 EXOSC9 EXOSC8 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation BTRC MAP3K8 MAP2K2;MAP2K1 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors NPPC NKX2-5 TBX5 HIPK1 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway GNAI2 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 PON1 PON3 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell STAM2 SH3KBP1 EPS15 CBL DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD OPLAH RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle RHOBTB3 CCNE1 RAB9A SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 UBTF GTF2H3 TAF1D ERCC3 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification AKR7A3 GGT1 DPEP1 MGST3 MGST1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events PLCB4 DAGLA DGKB CHRM5 MLN GPRC6A RGS2 BDKRB2 BDKRB1 GAST PROK1 PRKCH DGKZ LTB4R2 DGKK RGS17 GRP LPAR1 LPAR2 LPAR3 LPAR4 TRPC6 PROKR1 P2RY2 P2RY1 PIK3R1 TAC3 OPN4 NMB P2RY11 XCL1;XCL2 CCK LPAR5 NMS FFAR3;GPR42 MGLL F2RL2 EGFR MAPK1 BTK CYSLTR1 MCHR1 FFAR1 GNA14 GNB2 F2 AVPR1B GNB1 GNB4 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs CAMKK2 PRKAG2 PRKAG3 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS PLA1A PLAAT3 LPCAT4 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation RPA3 POLD4 RFC1 GINS1 GINS2 CDC45 MCM8 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA RPA2 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 SFTPD CSF2RA INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GRP CDX2 FFAR1 GIP GNB1 CTNNB1 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization PIK3R1 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDK6 CDKN2A TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins TAC3 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance APOA1 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions CDON RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle PKN2 RACGAP1 GOPC PKN1 PTPN13 RHOA DOCK1 DDX39B MTR-1 RAB7A CDC37 ERBIN DSP TMOD3 TXNL1 SEMA4F TNFAIP1 LEMD3 RND3 JAG1 CKAP4 KTN1 VANGL2 KCTD13 PKP4 ANKRD26;CCDC144A;LOC105375816 PICALM CPNE8 PLXND1 PRAG1 FAM13B WIPF3 FRS2 FAM13A PIK3R1 ARHGDIG SYDE2 PREX2 GOLGA3 PREX1 ARHGAP42 BAIAP2L1 OPHN1 FNBP1 TPM3 ACTN1 CYBB CYBA TEX2 BCR ALDH3A2 DAAM1 SPATA13 ABCD3 STAM2 ARHGAP17 ARHGAP15 IQGAP2 IQGAP3 ARHGAP22 MYO6 STK38 PLXNA1 ABL2 NCKAP1L SRGAP2 SRGAP1 MCAM DIAPH2 DIAPH3 NOXA1 NDUFS3 NOX3 MAP3K11 ACTC1;ACTG2 RASGRF2 C1QBP EFHD2 SPTAN1 EMD GIT1 ARHGEF11 NUDC PLEKHG1 ARHGEF15 ATP6AP1 CCDC115 ARHGEF17 ARAP2 RHOF LBR RHOD NIPSNAP2 SENP1 CDC42EP1 PKN3 WAS FAM169A SH3BP1 SLITRK3 NHS DOCK7 EMC3 SLITRK5 STOM CSK RBBP6 WASF2 WASF3 FARP1 USP9X CDC42BPA MYO9A ABI2 CCT7 CDC42 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation IRS2 IRS1 RHOA PIK3R1 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane DAD1 CSNK2B CSNK2A1;CSNK2A3 RPN2 RPN1 PCSK7 GANAB CTNNB1 TMEM258 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 BTRC PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function ZFPM1 SETD1B HDAC1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GATA1 TNRC6A-1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism AKR1B1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD4 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation RHOA CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GRP CDX2 FFAR1 GNB1 CTNNB1 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR AREG CSK STAM2 SH3KBP1 EPS15 ADAM17 EGFR CBL PTPN11 PIK3R1 CDC42 GAB1 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling PTK6 EGFR GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation ZC3H15 ARSJ ETF1 F10 ARSH ARSI F2 F9 DRG1 DPH5 DPH6 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes HDAC1 TCF7L1 CTBP1 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade C1QB C3AR1 CPB2 CR2 C7 C1R C9 C1QC F2 CPN1 CFB FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation POLR2L FGF7 FGF22 POLR2G GTF2F1 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function DAD1 RPN2 RPN1 H2BC15;H2BC3;H2BC11;H2BC12 GANAB EPS15 MPHOSPH8 FOXA2 EZH2 TNRC6A-1 CSNK2B TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PSMA7 MAPK1 STRAP MDM2-2 HDAC1 ZMYM2 BANP SNAI1 MCRIP1 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ZBTB33 RBBP7 FOXP2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PKM KLF9 CTBP1 TMEM258 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones HDAC1 BRMS1 HMG20B SAP30L GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PHF21A SAP30 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling TLR4 BACH1 APOA1 NCOA6 CRTC1 APOB SLC46A1 TGS1 MEF2C NRIP1 CRTC3 LY96 RAI1 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism ITPK1 NUP85 PLCD1 ITPKB PLCG2 NUP88 PLCB4 SEC13 NUP133 IP6K3 IP6K2 PLCH2 INPP4A SYNJ1 NUDT11;NUDT10-1 INPP1 PLCZ1 NUP205 NUP107 MIOX MTMR7 INPP5B ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells EPCAM SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants CDC37 ERBIN EGFR PIK3R1 GAB1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere POLA2 STN1 RFC3 RFC4 DSCC1 RFC2 POLD4 PCNA RFC1 TERF2IP TERF2 RFC5 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation FGF22 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling BTK PLCG2 PIK3R1 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription INS;INS-IGF2 GCK NR3C1 PCK1 G6PC1 SMAD4 AKT2 NPY AKT3 HDAC1 PCBP4 AGRP SOD2 AKT1 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CCNB2 PSMC2-1 CCNB1 PSMA7 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP3 CHMP6 ISCU PIK3R4 CHMP2B DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) RPA3 PARG POLB POLD4 RFC1 PARP2 RFC5 RFC3 RFC4 RFC2 PCNA NTHL1 TDG RPA2 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation ZMYM2 ERLIN2 FGFR1OP2 BCR PIK3R1 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus NUP85 NUP88 SEC13 NUP133 NUP205 NUP107 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer AREG EGFR BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism INS;INS-IGF2 CPA3 RAB27A ERO1B ENPEP CDX2 FFAR1 CPB1 GIP ACE IGF1 INHBC CLTRN ANPEP CTNNB1 CPE CTSG CPB2 CMA1 GRP MYO5A GNB1 EXOC7 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling CRLF1 JAK1 TYK2 EBI3 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation XPC AR PIAS3 SUMO1 CBX4 SATB1 VDR RARA NR3C1 BMI1 ING2 PHC3 TOP2B SMC6 NOP58 PCNA NSMCE1 WRN NSMCE4A NUP205 NUP107 PML NUP85 SENP1 NUP88 SEC13 NUP133 HERC2 XRCC4 SATB2 MDM2-2 NPM1-2 HDAC1 MITF PCGF2 TDG SMC3 STAG2 NRIP1 CTBP1 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR UNC93B1 TLR7 CNPY3 HSP90B1 LGMN RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CDC37 BIRC2 PDCD6IP BIRC3 ITCH PELI1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade PPP2R5D UBE2V1 NOD1 IRAK1 S100A1 MEF2C MAP3K8 LY96 TRAF2 TLR4 S100A9 TAB2 MAP2K2;MAP2K1 MAPK1 FGB FGA BTK BTRC ECSIT RIPK2 FGG USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling MAPK1 FGF22 CBL PTPN11 FRS2 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 MAPK1 FGF19 CBL PTPN11 FRS2 PIK3R1 KLB GAB1 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle SPTAN1 GIT1 USP9X TPM3 TXNL1 MYO9A PIK3R1 MAP3K11 CDC42 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle EDEM3 RNF103 RAD23B RNF139 TRIM13 EDEM2 SYVN1 UGGT2 GANAB UGGT1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions MYH10 RHOA MYH9 CDK5 ARHGEF11 SEMA7A CRMP1 PLXND1 DPYSL5 SEMA5A DPYSL2 DPYSL3 PLXNA2 PLXNB3 PLXNA1 CFL1 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 FGF7 FGF22 PTPN11 FRS2 PIK3R1 GAB1 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME HSD11B1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis CDH15 CTNNA2 NTN3 MAPK14 CDON MYOG MEF2C CTNNB1 CDH4 CDC42 CDH2 MYOD1 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation NUP85 RCC1 SEC13 SUMO1 NUP133 NUP205 NUP107 AHCTF1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening CACNA2D1 CACNA1B DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling AKT2 AKT3 CDC37 MATK ERBIN EGFR AKT1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH D2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 SETD1B CBX4 LIFR FOXP3 BMI1 ITCH PHC3 H2BC15;H2BC3;H2BC11;H2BC12 ZFPM1 AUTS2 IL2 CDK6 LDB1 PTPN11 TNRC6A-1 PML CSNK2B CSNK2A1;CSNK2A3 PSMD8 PRKCB PSMA6 CTLA4 PSMD12 PSMD11 PSMB1 SERPINB13 PBRM1 PSMC2-1 PSMA7 HDAC1 MYB RYBP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GATA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CSF2 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex TLR4 TAB2 LY96 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization USP7 PML NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists SFRP1 KREMEN1 WNT5A DKK1 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol PUS3 TRMT112 CTU2 TRMT10A TRMT6 TPRKB TP53RK TRMT13 C9orf64 TRMT61A ADAT3 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway RPA3 ATR MUS81 EME1-1 EME2 SLX1A;SLX1B DCLRE1A LOC105377022;FANCB UBE2T FAN1 FANCI FANCC RPA2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state FZR1 UBE2C PSMD8 RBX1 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 MCM8 PSMB1 PSMC2-1 PSMA7 GMNN CCNA1 ORC1 CCNE1 ORC2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines XCL1;XCL2 CCL13;CCL2 CCL22 CXCL8 CCL20 ACKR4 CXCL5;CXCL6 CCL3L1;CCL3L3;CCL3;CCL18 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling FAS REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription SNAI1 ILF3 HOXC8 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells SNW1 MAMLD1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases KLC2 PKN2 RACGAP1 GOPC B9D2 PKN1 PTPN13 KIF18A RHOA H2BC15;H2BC3;H2BC11;H2BC12 KIF2C DOCK1 DDX39B MTR-1 RAB7A CFL1 S100A9 MYH9 CTNNB1 MAPK1 MAPK14 PIN1 NUP107 NUP85 SEC13 NUP133 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C AR CDC37 ERBIN DSP TMOD3 TXNL1 SEMA4F TNFAIP1 LEMD3 RND3 JAG1 CKAP4 KTN1 VANGL2 KCTD13 PKP4 ANKRD26;CCDC144A;LOC105375816 PICALM CPNE8 PLXND1 PRAG1 FAM13B WIPF3 FRS2 FAM13A PIK3R1 ARHGDIG SYDE2 PREX2 GOLGA3 PREX1 ARHGAP42 BAIAP2L1 OPHN1 PRKCB FNBP1 PPP1CC TPM3 ACTN1 DYNC1I2 CYBB CYBA TEX2 BCR ALDH3A2 DAAM1 SPATA13 BTK ABCD3 STAM2 ARHGAP17 ARHGAP15 DYNC1H1 IQGAP2 IQGAP3 SKA1 SKA2 ARHGAP22 MYO6 STK38 PLXNA1 ABL2 NCKAP1L SRGAP2 MYH10 SRGAP1 SCAI MCAM ARPC4 PTK2 DIAPH2 DIAPH3 NOXA1 NDUFS3 PIK3R4 NOX3 ACTR3-1 NF2 MAP3K11 ACTC1;ACTG2 AHCTF1 RASGRF2 C1QBP NUF2 EFHD2 SPTAN1 EMD GIT1 ARHGEF11 ACTR2 NUDC PLEKHG1 ARHGEF15 ATP6AP1 CCDC115 ARHGEF17 ARAP2 RPS27 RHOF LBR RHOD NIPSNAP2 SENP1 CDC42EP1 EVL PKN3 MEN1 WAS FAM169A CENPA NSL1 SH3BP1 SLITRK3 NHS DOCK7 EMC3 SLITRK5 STOM FLNA CSK RBBP6 WASF2 WASF3 FARP1 USP9X CDC42BPA MYO9A KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF ABI2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI CCT7 TAOK1 CENPM CDC42 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine MAOA COMT LRTOMT HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors FSHR TSHR GPHB5 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters ATP6V1H HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E AP2A1 AP1S3 AP2A2 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD AHCY LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux APOC1 CETP EEPD1 KDM3A KDM1B APOE KDM1A APOC2 TNRC6A-1 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown NUP85 NUP88 CNEP1R1 LPIN1 SEC13 PRKCB NUP133 LEMD3 CCNB2 CCNB1 EMD NUP205 NUP107 NEK9 NEK6 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling MAPK1 CBL PTPN11 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance TFDP1 B9D2 MTERF1-1 DEUP1 MICOS10 MCIDAS TWNK TFB2M POLG2 GMNC CCNO PERM1 MTX2 DNAJC11 IMMT MEF2C ATP5MC1 SOD2 TNRC6A-1 HSPA9 IDH2 DYNC1I2 DCTN2 SSNA1 GLUD1;GLUD2 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 MAPK14 CAMK4 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CRTC3 CENPJ ALMS1 CEP63 IFT140 IFT122 PRKAG3 IFT52 SMO ESRRA ARL6 PKD2 TGS1 MCHR1 TCTN3 BBS7 EXOC7 SCLT1 TTC26 KIF24 IFT43 RAB11A IFT81 AHI1 DYNLT2B NCOA6 CRTC1 HCFC1 PRKAG2 GMNN MYB PPARGC1B CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily NQO1 FAM124B IGF2 CHD6 AXIN2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CTNNB1 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis PAICS PPAT G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation GNA14 GNB2 GNB1 GNB4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway CDC42 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation SLC9A1 HEXB HYAL3 CEMIP CHP1 HMMR CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage GSDMD CASP3 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules PLCG2 CD3G EVL ITK HLA-DPB1-1 WAS HLA-DPA1 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation TLR4 S100A9 PSMD8 PSMA6 PSMD12 ITGAV PSMD11 CYBB CYBA PSMB1 PSMC2-1 PSMA7 FGB FGA BTK S100A1 FGG SEC61A2 CD207 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SEC22B MYD88 LY96 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound MYO7A EPS8 PCLO STRC CDH23 KCNMB1 XIRP2 OTOF KCNN2 TPRN MYH9 SLC17A8 ATP2B1 CAPZA1 SPTAN1 RIPOR2 RDX CHRNA9 CIB2 PJVK SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 SMAD4 ARRB1 PSEN2 APH1A RARA PSENEN MYOG TGFB2 TGFBR1-1 TNRC6A-1 MYOD1 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade SERPINE2 F10 F11 F2 F9 ANO6 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) MAPK1 PPP2R5D EGR1 ID4 MAPK14 TRIB1 TPH1 MEF2C CDK5 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs STRAP SMAD4 PPP1R15A USP15 PPP1CC ITGAV CBL MTMR4 TGFB2 TGFBR1-1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling AKT2 AKT3 AKT1 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM-2 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP4F3;CYP4F2;CYP4F12;CYP4F11 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling TLR7 UBE2V1 MYD88 IRAK1 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation INS;INS-IGF2 IRS2 IRS1 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption SLC5A1-1 RSC1A1 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism PYGB PPP1R3C PYGM PGM1 AGL-1 PYGL NHLRC1 GAA MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST3GAL4 ST6GALNAC3 ST6GAL1 ST3GAL1 ST3GAL3 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins KLC2 POLR2L RACGAP1 MPHOSPH6 RFC1 KIF18A BATF CAPZA1 MAF KIF2C DCTN1 HLA-DPB1-1 HLA-DPA1 RAB7A DYNC1I2 DCTN2 IL21 MYH9 CD84 LOC102723996;ICOSLG AFF4 ACTR1A TNFSF13B CTSH CTSF HLA-DOA MAD2L2 POLH CR2 REV1 MLLT3 SUPT6H DYNC1H1 SH2D1A DIS3 APEX2 ACTR10 EXOSC6 EXOSC4 EXOSC9 EXOSC8 EXOSC2 EXOSC1 ICOS EXO1 CTSA RFC5 RFC3 RFC4 RFC2 PCNA E2F7 E2F8 CTNNBL1 ELL TAF7L E2F2 POLR2G NCOA6 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CTR9 TAF7 TAF5 TAF2 MYB DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) SV2A SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy CSNK2B MFN1 UBE2V1 CSNK2A1;CSNK2A3 MFN2 UBE2D3;UBE2D2 EPAS1 PRKAG3 DYNC1I2 TBK1 PRKAG2 PLIN2 VDAC1 DYNC1H1 VDAC3 TOMM7 ATG5 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress HSPA12B DNAJC2 DNAJC7 ATR MLST8 PTGES3-1 BAG2 NUP205 RPA2 NUP107 CAMK2B CAMK2D CAMK2A NUP85 RPA3 HSPA9 CAMK2G NUP88 SEC13 NUP133 MAPK1 AKT1S1 HSPA4L HSPA14 CCAR2 FKBP4 BAG3 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RIPK1 TLR4 LY96 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle CDC37 DDX39B TMOD3 TXNL1 ACTN1 MYO6 STK38 CCT7 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer TGFBR1-1 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling APOB APOA2 APOC3 APOA1 APOE APOA4 APOC2 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein NUP85 NPM1-2 RCC1 NUP88 SEC13 NUP133 NUP205 NUP107 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing POLR2L SNW1 WBP11 PRPF6 PPIH PPIG PRPF8 BUD31 HNRNPA1-1 DDX39B DHX38 HNRNPA2B1 SNRPA1 HNRNPR NSRP1-1 PPWD1 PNN RBMX2 SNRPF PRPF4B PRPF40A CXorf56-1 PRPF18 PRPF3 PQBP1 C9orf78 SNRNP27 SNRPC ISY1;ISY1-RAB43 CACTIN SF3B6 CWF19L2 DHX35 SRSF10 XAB2 PRPF38A PPIL2 PHF5A SNRPE-2 CCDC12 SNRPN LSM2 SNRPG-2 LSM8 CHERP CTNNBL1 PUF60 PPIL4 POLR2G SRRM2 GTF2F1 SUGP1 PPIL1-1 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation AREG STAM2 SH3KBP1 EPS15 EGFR CBL CDC42 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F12 F2 KLKB1 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling PPP2R5D UBE2V1 NOD1 IRAK1 BIRC2 BIRC3 MEF2C PTPN11 MAP3K8 LY96 RIPK1 TRAF2 TLR4 TAB2 UBE2D3;UBE2D2 MAP2K2;MAP2K1 TBK1 MAPK1 BTRC RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 JUN DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis PSMD8 PSMA6 ERLIN1 ERLIN2 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly CIAO2B NDOR1 RTEL1 NUBP1 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism ENO1 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia NMRAL1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere NPM1-2 MIS18A RSF1 CENPA H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CENPI RUVBL1 CENPM FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGFR3 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis PLCG2 CD3G AHCYL1 PRKACB-1 PRKAR1A PRKAR2A DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases USP15 MCRS1 PSMD8 PSMA6 PSMD12 KDM1B PSMD11 HCFC1 RUVBL1 PSMB1 TGFBR1-1 YY1 PSMC2-1 PSMA7 BARD1 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants CDC37 ERBIN EGFR PIK3R1 GAB1 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling JAK1 PTPN11 TYK2 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO SLIT3 DCC SLIT1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors PRKCB AP2A1 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 CEP63 DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 HMMR NEDD1 CENPJ ALMS1 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) SYT2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding TBC1D8B RAB5C SORT1 HIP1R ARRB1 AP3B1 TPD52L1 AP1G2 BLOC1S4 BLOC1S1 DNAJC6 FTH1 BLOC1S3 M6PR AP1S3 PICALM GNS DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis PCK1 NRIP1 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels KCNIP3 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors PPP2R5B KLC2 PKN2 PPP2R5A GOPC PPP2R5D B9D2 PPP2R5C PKN1 AR RHOA H2BC15;H2BC3;H2BC11;H2BC12 KIF18A KIF2C KTN1 WIPF3 CFL1 S100A9 PRKCB PPP1CC DYNC1I2 CYBB CYBA MYH9 CTNNB1 DAAM1 MAPK1 BTK DYNC1H1 IQGAP2 IQGAP3 SKA1 MAPK14 SKA2 NCKAP1L PIN1 SRGAP2 MYH10 SCAI ARPC4 PTK2 DIAPH3 NOXA1 PIK3R4 NOX3 ACTR3-1 NF2 AHCTF1 NUF2 ACTR2 NUDC NUP107 RPS27 RHOD NUP85 EVL SEC13 PKN3 MEN1 WAS NUP133 CENPA NSL1 FLNA WASF2 WASF3 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF ABI2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI TAOK1 CENPM PPP2R5E CDC42 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family PPP2R5B PPP2R5A PPP2R5D PPP2R5C EPAS1 H2BC15;H2BC3;H2BC11;H2BC12 MIB2 EZH2 HLA-DPB1-1 HLA-DPA1 MAP3K8 PIK3R1 TNRC6A-1 CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 CTLA4 PSMD12 TEAD2 PSMD11 TEAD3 TEAD4 PSMB1 LOC102723996;ICOSLG MAGT1 CTNNB1 PSMC2-1 PSMA7 MAPKAP1 AKT2 AKT3 BTRC TRIB3 CD3G JAK1 AKT1 PIK3R5 TMEM258 DAD1 RBX1 ERLIN1 PRKAG3 PDCD1LG2 RPN2 ERLIN2 MAP3K14 RPN1 MLST8 BRD4 PIK3CG PTPN11 STT3B PRKAG2 BTLA CSK TCF7L1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPP2R5E CDC42 JUN SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) FFAR1 GIP TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway TRAF2 PSMD8 PSMA6 PSMD12 MAP3K14 PSMD11 TNFRSF13B TNFSF15 TNFRSF9 TNF EDA2R PSMB1 LTA PSMC2-1 TNFSF9 PSMA7 TNFSF13B BTRC BIRC2 TNFRSF1A BIRC3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand FGB GSDMD FGA TLR7 GSDME APOB TLR4 S100A9 S100A1 FGG LY96 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins DEFB129 DEFB127 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions ANK1 CNTN6 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes DCSTAMP CREB3 CREB3L1 MBTPS1 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders SLC5A1-1 NUP85 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NUP88 SLC29A3 SEC13 SLC7A7 NUP133 GCK SLC6A5 SLC12A6 SLC6A2 SLC40A1 SLC17A8 SLC35A1 HEPH SLC22A12 SLC22A18 SLC26A2 AVPR1B NUP205 NUP107 SLC20A2 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling MYH10 ARHGEF11 RHOA MYH9 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis GPAT2 DGAT2 LPIN1 MOGAT3 MOGAT1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin MAOA SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III TUBA1A TUBB2B;TUBB2A TUBAL3 CHMP3 CHMP6 CHMP2B DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A1 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 SNW1 JAG2 HDAC5 ARRB1 PSEN2 RBX1 MAMLD1 APH1A CDK8 ITCH PSENEN JAG1 HDAC1 MIB2 HES5 CCNC-1 ADAM17 MIB1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer MAPK1 BCL2A1 NPM1-2 HDAC1 ICOS PRF1 RBX1 GZMH;GZMB-1 FOXM1 CCNB1 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle IDH2 SDHC SDHAF1 SDHB LYRM4 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects ADA PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation POLR2L POLR2G SSRP1 GTF2F1 ELL RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway ADH4 SDR16C5 DHRS9 CRABP1 RDH14 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching SLIT1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest PCBP4 CCNA1 CCNE1 E2F7 E2F8 ZNF385A DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RPA3 ATR RAD9A PALB2 EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 RBBP8 RPA2 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription EGR1 ID4 TRIB1 TPH1 CDK5 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 RHOA CRK DOCK1 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) RPA3 POLD4 PCNA EXO1 RPA2 RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle PKN2 RACGAP1 PREX1 PKN1 MCAM ERBIN OPHN1 PKN3 DIAPH3 BCR ACTC1;ACTG2 DAAM1 STOM ARHGEF11 IQGAP3 MYO9A PIK3R1 ARHGEF17 ARHGDIG REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL CBL PIK3R1 CRK BLNK BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions BTN1A1 PPL XDH DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation POLA2 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CDC37 BIRC2 PDCD6IP BIRC3 ITCH PELI1 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling PDCD4 IL12B HSPA9 SNRPA1 IL12A IL12RB1 IL12RB2 TALDO1 CAPZA1 EBI3 CRLF1 JAK1 CA1 TYK2 SOD2 CFL1 CDC42 HNRNPA2B1 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAPK1 MAP2K2;MAP2K1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade INS;INS-IGF2 PIK3R4 FLT3 KLB GAB1 MAPK1 IRS2 AKT2 FGF7 TRIB3 FGF22 FGF19 PDE3B IRS1 PTPN11 FRS2 PIK3R1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP63 DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism CYB5A SLC23A2 SLC23A1 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 BDNF DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 PTPN11 FRS2 PIK3R1 GAB1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors APOB MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST3GAL4 ST6GALNAC3 ST6GAL1 ST3GAL1 ST3GAL3 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism SLC52A1;SLC52A2 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RABGGTA BCL2L14 PERP ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism ADAL PCK1 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling IL12A IL12RB2 JAK1 TYK2 EBI3 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells CTNNB1 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) TFDP1 E2F2 TFDP2 CDK6 E2F3 CCNE1 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis ST3GAL4 B3GNT2 ST3GAL6 ST3GAL1 ST3GAL3 ACAN CHST2 SLC35D2 B4GALT6 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors PABPC1;PABPC3 PABPN1-1 EIF4E EIF4B ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC25A17 PHYH-4 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle RBBP6 TXNL1 MYO6 STK38 CCT7 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin CCNA1 PSMD8 ORC1 PSMA6 ORC2 RBX1 PSMD12 PSMD11 MCM8 PSMB1 PSMC2-1 PSMA7 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol NOC4L IMP4 DDX52 RRP9 RCL1 RRP7A PDCD11 DKC1 BMS1 DCAF13 UTP14C;UTP14A NOP10 NOP58 TRMT112 UTP6 DDX49 UTP11 FCF1 NAT10 WDR75 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB PRKACB-1 PRKAR1A PRKAR2A REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity MDM2-2 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli TFDP1 TFDP2 E2F3 EPAS1 PTK6 CAPZA1 STAP2 CHD6 EIF2S2 EIF2S3;EIF2S3B ATP6V1H TRPV4 SOD2 LY96 TLR4 BACH1 UBE2D3;UBE2D2 TERF2IP SLC7A11 TERF2 MAPKAP1 MAPK1 MDM2-2 APOB CCNA1 RPL4 RPL30 RPL31 ACTR10 RPL6 HSPA4L RPL7 HSPA14 CCAR2 BAG3 HSPA12B RPL35 DNAJC2 RPL38 ATR DNAJC7 RPL39 RPL22 MLST8 DCSTAMP CREB3 CREB3L1 RPL29 RPA2 RPA3 LAMTOR2 PPP1R15A ITGAV MT2A LONP1 PREB PPP2R2A;PPP2R2D ASF1A NPRL2 WDR59 H1-3 H1-2 H1-5 HIF3A LIMD1 MINK1 DEPDC5 RAMP2 MAP4K4 CDKN2D NRIP1 CDKN2C CASTOR1 FKBP4 YIF1A CASTOR2 MAP3K5 SZT2 ERN1 AR CACNA1H KLHDC3 MTF1 HMGA2 FLT4 GPX7 TKT NR3C1 PECAM1 HM13 SH3BP4 DNAJA4 BMT2 RPL18 CSNK2B CSNK2A1;CSNK2A3 DYNC1I2 CYBB DCTN2 SYVN1 CYBA RPL37A-1 ACTR1A AKT1S1 BTRC DYNC1H1 AJUBA PTK2 BAG2 RPL7A ME1 E2F2 DNAJA2 KDR APOA1 ARNT NCOA6 SEC31A CXXC1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PKN2 TXNRD1 CBX4 BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 GFPT1 DCTN1 SLC46A1 EZH2 MEF2C ATOX1 CHAC1 PSMD8 PSMA6 PSMD12 PSMD11 TALDO1 PSMB1 CTNNB1 PSMC2-1 PSMA7 TRIB3 CDKN2B HSP90B1 DIS3 MAPK14 EXOSC6 EXOSC4 EXOSC9 EXOSC8 AKT1 DCP2-1 EXOSC2 EXOSC1 RBX1 PRKACB-1 PRKAR1A PRKAR2A CDK6 NUP205 NUP107 CAMK2B CAMK2D COX7C CAMK2A NUP85 CAMK2G NUP88 SEC13 NUP133 CRTC1 NQO1 PPP2R5B COX6C PALB2 PHB2 COX6A1 COX6A2 TCIRG1 G6PD ATP6V0D2 ATP6V1A HIGD1A P2RY2 TNRC6A-1 HSPA9 IDH1 FZR1 UBE2C CDKN2A CDC26 ATP6V1F ANAPC1 ANAPC10 ANAPC11 RPS15 AKT2 AKT3 RPS11 RPS13 CRTC3 RAI1 PTGES3-1 TGS1 MBTPS1 RPS25 RPS27 RPS29 P2RX7 FAU RPS21 RPS24 TRIM21 AREG CCNE1 GNB2 CXCL8 GNB1 GNB4 JUN ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME CYP2D6;LOC107987479;LOC107987478-1 CES2 GLYATL3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ACSM5 ACSM4 GLYAT UGT2A1 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease POLR2L FGF7 FGF22 POLR2G FRS2 PIK3R1 GTF2F1 GAB1 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A WAPL KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 PSMD8 UBE2C SEC13 PSMA6 CDC26 PSMD12 PPP1CC NUP133 ANAPC1 DYNC1I2 PSMD11 CENPA ANAPC10 NSL1 ANAPC11 PSMB1 PSMC2-1 PSMA7 DYNC1H1 SKA1 SKA2 SMC3 CENPF STAG2 CENPI TAOK1 CENPM PPP2R5E HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs DNAJA2 AR DYNC1I2 NR3C1 DCTN2 DNAJA4 CAPZA1 ACTR1A PTGES3-1 DCTN1 DYNC1H1 ACTR10 FKBP4 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines PRMT7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PBRM1 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins DSP PKP1 CTNNB1 CASP3 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response PSMD8 RBX1 PSMA6 SUMO1 PSMD12 PSMD11 DDB1 HERC2 H2BC15;H2BC3;H2BC11;H2BC12 PSMB1 EYA1 PSMC2-1 EYA3 PSMA7 APBB1 BARD1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KDM4B CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation PPP3CB AHCYL1 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage CASP3 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis STIM1 P2RX4 ORAI2 P2RX7 TRPC6 ATP2B2 ATP2B1 SLC8A1 SLC8A2 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins SUMO1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER RFC3 RFC4 RPA3 RFC2 POLD4 PCNA RFC1 RPA2 RFC5 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport PSMD8 ERLIN1 PSMA6 APOA1 ERLIN2 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 ABCD3 ABCA2 ABCA8 ABCF1 EIF2S2 EIF2S3;EIF2S3B ABCB6 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry RAB5C GPC3 GPC2 TLR4 GPC4 SDC3 EGFR LY96 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease LSM2 DCP2-1 RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs FLNA MYH10 MYH9 NF2 CDC42 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) CTSG GSDMD C3AR1 P2RX4 PYCARD P2RX7 CASP1 SUGT1 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA GPAT4 GPAT2 LPCAT4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation CEP63 TUBGCP5 TUBGCP6 TUBGCP4 CDK11A;CDK11B DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm SMAD4 FOXA2 CTNNB1 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se AHCY GNMT CBS;CBSL ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants FLT3 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K VKORC1L1 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib CDC37 ERBIN MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels HDAC1 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol CYP7B1 CYP7A1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts ABCD3 SLC27A5 HSD17B4 CYP7B1 CYP7A1 CYP39A1 AMACR STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 CASP3 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) KCNK9 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 FGF22 PTPN11 FRS2 PIK3R1 GAB1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils BMP1 LOXL3 LOXL1 PXDN TLL1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) FGB FGA CSK PTK2 FGG F2 APBB1IP ADRA2A RAP1A AKT1 CRK IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus NUP85 NUP88 SEC13 NUP133 NUP205 NUP107 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R IGF2 IGF1 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA POLD4 RFC1 RBX1 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA RPA2 RPA3 FZR1 PSMD8 UBE2C PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 GINS1 ANAPC11 GINS2 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 GMNN CCNA1 ORC1 ORC2 CCNE1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 PKN1 AR H2BC15;H2BC3;H2BC11;H2BC12 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH SNW1 TFDP1 ELF3 TFDP2 HDAC5 ARRB1 ST3GAL6 JAG2 E2F3 RBX1 MAMLD1 FLT4 CDK8 ITCH H2BC15;H2BC3;H2BC11;H2BC12 GZMH;GZMB-1 JAG1 ST3GAL4 HES5 MIB2 ADAM17 WWC1 ST3GAL3 PLXND1 FCER2 MDK TNRC6A-1 PSEN2 PSMD8 PSMA6 APH1A PSMD12 EGFR PSMD11 PSENEN PSMB1 PSMC2-1 PSMA7 HDAC1 CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NOTCH3 AKT1 MIB1 JUN TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis RHOA INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling JAK1 IL21R IL21 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions SPTAN1 ACTN1 MAGI2 PIK3R1 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud HOXA11 GDNF SIX2 EYA1 HOXD11 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHA SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin INS;INS-IGF2 IGF1 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation FBXL19 COPS7B KLHL2 FBXL16 COPS7A FBXL14 KLHL20 SPSB2 RBX1 SPSB1 EPAS1 PALB2 DDB1 ASB7 COPS8 DCUN1D3 DDA1 COP1 ANKRD9 NAE1 DCAF10 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD4 NEURL2 PSMD8 CCDC22 UBE2D3;UBE2D2 PSMA6 OBSL1 FBXO21 PSMD12 PSMD11 DCAF13 PSMB1 FBXO7 FBXW8 PSMC2-1 KCTD7 PSMA7 FBXW4 BTRC HIF3A ASB16 FBXL20 BTBD1 RBBP7 KLHL25 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 PTK6 STAP2 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production GGT1 CYSLTR1 DPEP1 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins DAD1 NMT1 KPNA4-1 SUMO1 RPN2 APOA1 STT3B RPN1 MAGT1 TMEM258 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport TIMM21 NDUFA7 RANBP9 NDUFA3 COX6C SDHAF1 L2HGDH NDUFA12 COX6A1 COX6A2 MDH1 MDH2 SDHC SDHB LYRM2 HIGD1A ATP5MC1 LYRM4 HSPA9 IDH2 HIGD2A MPC2 BCS1L COX20 VDAC1 PC SMIM4 UQCRFS1 NDUFS8 MPC1L NDUFS3 NDUFS2 COA3 TRAP1 SCO1 SCO2 RMND5B UQCRC2 NDUFAF2 C12orf73 NDUFAF1 ME1 IDH3B HSCB COX7C NNT OGDH SLC25A18 NDUFB8 ECSIT NDUFB6 TMEM186 NDUFB4 NDUFB2 NDUFB1 RAB5IF SLC25A27 D2HGDH DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome CASP1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes PPP2R5B GFPT1 DCTN1 CXXC1 KLHDC3 SYVN1 PREB YIF1A SEC31A TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade RIPK1 PPP2R5D TRAF2 UBE2V1 TAB2 UBE2D3;UBE2D2 NOD1 IRAK1 MAP2K2;MAP2K1 TBK1 MAPK1 BTRC BIRC2 RIPK2 USP14 MAPK14 BIRC3 NKIRAS1 NKIRAS2 MEF2C MAP3K8 JUN ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes APOA4 APOC2 MBTPS1 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair NTHL1 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants KIT PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 FGF19 PTPN11 FRS2 PIK3R1 KLB GAB1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination POLR2L SSB POLR3A NFIB POLR3D POLR3F POLR3K SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism SERINC3 SERINC2 SERINC4 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription TFDP1 E2F6 TFDP2 HDAC1 CCNA1 PCNA ORC1 CCNE1 LIN52 TYMS CDC45 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation HGF DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis MTERF1-1 PRKAG3 MICOS10 ESRRA TWNK TFB2M POLG2 PERM1 MTX2 DNAJC11 IMMT TGS1 MEF2C ATP5MC1 SOD2 HSPA9 IDH2 NCOA6 CRTC1 GLUD1;GLUD2 HCFC1 PRKAG2 MAPK14 CAMK4 CRTC3 PPARGC1B RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates WRN MUS81 BARD1 EME1-1 EME2 RBBP8 PALB2 SLX1A;SLX1B EXO1 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell KLRB1-1 CRTAM SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 ICAM5 LILRA5-4 PVR CD1A TREML1 LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 JAML SIGLEC1 CD3G RAET1E-1 SH2D1A NECTIN2 CD99 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential KCNK9 KCNK10 KCNK2 KCNK4 KCNK6 KCNK7 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency PC DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO2 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange RPA3 ATR RAD9A EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 RBBP8 RPA2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP2D6;LOC107987479;LOC107987478-1 ARNT2 CYP11B1;CYP11B2 CYP2S1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ARNT CYP7B1 CYP7A1 CYP39A1 POR SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea MYO7A EPS8 PCLO STRC CDH23 KCNMB1 XIRP2 OTOF TPRN MYH9 SLC17A8 ATP2B1 CAPZA1 SPTAN1 RIPOR2 RDX CIB2 PJVK GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling PPP1CC MRAS BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) LTC4S PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism VDAC1 PC RANBP9 RMND5B MPC1L MPC2 ME1 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism PPP2R5D ST3GAL6 TKT CHST2 HAS3 PFKP SLC35B3 G6PD SHPK HS6ST2 FUT9 GALM-2 GCK TALDO1 CHP1 CRYL1 MAN2B1 PPP1R3C PC RPE;RPEL1 GAPDH-1 PFKFB2 PFKFB1 PFKFB4 XYLT2 SLC26A2 ENO1 CEMIP ENO2 PFKFB3 SLC35D2 HMMR NDST3 SLC9A1 PRKACB-1 SDC3 ACAN PCK1 GLCE LALBA B4GALNT2 B4GALT6 G6PC1 FBP2 ST3GAL4 HPSE GPC3 DERA GPC2 NHLRC1 GPC4 ST3GAL1 ST3GAL3 CHSY3 NUP205 NUP107 GNS AKR1B1 PGM2 SLC37A4 NUP85 HS3ST2 PGM1 NUP88 SEC13 NUP133 GAA GPI FAM20B PYGB B3GNT2 PYGM AGL-1 PYGL HEXB HYAL3 CSPG5 B3GALT2 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes RFC3 RFC4 MAD2L2 RFC2 REV1 POLH PCNA RFC1 APEX2 RFC5 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex TFDP1 TFDP2 HDAC1 PCNA LIN52 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants FLT3 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine CBS;CBSL GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) BTRC PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation TSPAN15 INS;INS-IGF2 ITM2B APOA1 APH1A APOE APOA4 H2BC15;H2BC3;H2BC11;H2BC12 PSENEN FGA USP9X GGA3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 APCS ODAM H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NAT8-2 SORL1 TSPAN33 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling MTTP CETP APOB FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases FLT3 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex RFC3 RFC4 RPA3 RFC2 POLD4 PCNA RFC1 RBX1 DDB1 RPA2 UBE2B RFC5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNB1 CCNA1 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization COL4A5 COL17A1 COL18A1 COL15A1 COL12A1 COL4A4 COL6A3 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates NME4-1 TXNRD1 AK4-1 TYMS NME1 NME6 RRM1 AK6 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling RANBP10 RANBP9 HGF TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TFDP1 TFDP2 PCNA ZNF385A CCNB1 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling PIK3R4 FLT3 KLB GAB1 IRS2 AKT2 FGF7 TRIB3 FGF22 FGF19 PDE3B IRS1 PTPN11 FRS2 PIK3R1 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism SLC22A13 SLC25A51;SLC25A52 NMNAT2 NUDT12 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ILK PARVA CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication H2BC15;H2BC3;H2BC11;H2BC12 DOCK1 EPS15 MPHOSPH8 BIRC2 EZH2 ITGB4 MAGI2 PIK3R1 TNRC6A-1 CDH11 CSNK2B PLEC TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 ACTN1 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PVR PSMA7 MAPK1 MDM2-2 JAK1 BANP SNAI1 NECTIN2 CLDN1 MCRIP1 ZBTB33 FOXP2 PKM TYK2 KLF9 TMEM258 CTBP1 DAD1 COL17A1 ILK ANG PARVA TESK1 CLDN2 PTK2 SIRPB1 RPN2 CDH8 CDH6 RPN1 CDH3 ZC3H12A CDH12 CDH13 GANAB CDH19 FBLIM1 CDH24 CADM2 PARVB CLDN23-1 SPTAN1 SDK1 NECTIN4 FOXA2 NECTIN1 PTPN11 MPP5 CDH4 CDH2 CDH15 STRAP FLNA HDAC1 ZMYM2 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ILF3 HOXC8 CDC42 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A F10 F2 F9 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins NEU1 ALG8 CTSA ALG3 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 KLC2 RHOA KTN1 CDC42 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 RPA3 ATR RAD9A EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 RBBP8 RPA2 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium ARL6 MCHR1 SMO BBS7 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs ARPC4 PTK2 WAS ACTR3-1 MAPK1 BTK WASF2 WASF3 ACTR2 ABI2 WIPF3 CDC42 NCKAP1L HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events NUP85 MVB12A NUP88 SEC13 NUP133 H2BC15;H2BC3;H2BC11;H2BC12 VPS25 CHMP2B UBAP1 CHMP3 CHMP6 CHMP1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP205 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP107 TSG101 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins TOP2B NUP85 PCNA NUP88 PIAS3 SEC13 SUMO1 NUP133 NUP205 NUP107 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis SMAD4 NKX2-5 TBX1 MESP1 LDB1 TBX5 MEF2C CTNNB1 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades PPP2R5D RBSN GSDME BIRC2 BIRC3 MEF2C MAP3K8 LY96 RIPK1 GSDMD TRAF2 TLR4 S100A9 UBE2D3;UBE2D2 MAP2K2;MAP2K1 TBK1 MAPK1 BTK BTRC APOB RIPK2 HSP90B1 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 TLR7 UBE2V1 PIK3R4 NOD1 IRAK1 S100A1 CNPY3 ITGAM TASL IRF5 LY86 PTPN11 UNC93B1 PLCG2 TAB2 LGMN FGB FGA ECSIT FGG JUN DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation TFB2M OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation RPA3 FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 H2BC15;H2BC3;H2BC11;H2BC12 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 POLA2 GMNN ORC1 ORC2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RPA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation CAMK2A PTGES3-1 AKT1S1 CAMK2G MLST8 CAMK2B FKBP4 CAMK2D TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins DAD1 ZDHHC9 MGAT4B ST6GALNAC3 SUMO1 RPN2 STT3B RPN1 MGAT4A-1 MAGT1 GANAB ZDHHC3 MGAT5 ST3GAL4 ST6GAL1 ST3GAL1 ST3GAL3 EDEM2 GOLGA7-1 SRPK1 TMEM258 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 IRS2 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants MAPK1 MAP2K2;MAP2K1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily PUF60 SNRPA1 SNRPF H2BC15;H2BC3;H2BC11;H2BC12 MYOG SSRP1 SF3B6 CTR9 MYOD1 PHF5A SNRPE-2 SNRPN SNRPG-2 CHERP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport ATP6V0A4 ATP6V1F SLC40A1 FTH1 HEPH TCIRG1 ACO1 SLC46A1 ATP6V0D2 ATP6V1A ATP6V1H ATP6AP1 FTMT TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation TRAF2 NKIRAS1 NKIRAS2 DDX58 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNA1 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle SRGAP2 GOPC PREX1 CDC42EP1 OPHN1 FNBP1 DIAPH3 STOM ARHGAP17 GIT1 IQGAP3 CPNE8 CDC42BPA RAB7A CDC42 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription SNW1 TFDP1 TFDP2 MAMLD1 ZFPM1 SOD2 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BDNF GCK TP53RK USP7 RHNO1 AFF4 MEAF6 MAPKAP1 MAPK1 MDM2-2 NPM1-2 PCBP4 BCL2L14 CCNA1 MLLT3 PRELID3A SUPT6H BANP BARD1 PABPN1-1 FANCI PRELID1 CRADD FANCC CNOT6 CNOT7 GLS JMY PIN1 CDK12 CNOT9 ATR PIP4K2C RAD9A BTG2 DYRK2 SETD9 PRKAG3 ING5 PIDD1 ING2 EXO1 MLST8 MED8 CASP2 ZNF385A RFC5 RFC3 RFC4 SCO2 RFC2 RABGGTA PCNA WRN PERP PLAGL1 RBBP8 RFFL E2F7 E2F8 RPA2 HIPK1 POU4F1 PML TTC5 RPA3 LAMTOR2 KDM5B PBRM1 GPI PRKAG2 AR SUMO1 VDR RARA NR3C1 KIT CSNK2B CSNK2A1;CSNK2A3 PRKCB EGFR CCNB1 CENPJ ESRRA G6PC1 NUDT21 INTS3 INTS2 PHF20 INTS7 INTS11 LBR INTS13 MED16 MED17 NABP2 SNAPC1 SNAPC2 RPRD2 MEN1 ARNT CTR9 MED23 MED24 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 PCF11 GLS2 USP9X H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZNF324B;ZNF324 PPARGC1B POLR2L ZNF382 SETD1B ZNF669;ZNF670 HDAC5 GTF2H3 TXNRD1 CBX4 GATAD2A BMI1 CDK8 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 YY1 MAF CDK5 ERCC3 MED31-1 EZH2 MEF2C ZNF605 ZNF555;ZNF57;ZNF556 ZNF713 ZNF157 ZNF398 TWIST2 ZNF707 PSMD8 NKX2-5 UCMA PSMA6 CTLA4 ZNF248 PSMD12 TEAD2 PSMD11 TEAD3 TEAD4 ZNF599 PSMB1 ZNF473 CTNNB1 PSMC2-1 SERPINB13 SATB2 PSMA7 ZNF557;ZNF558 NPY ZNF226 ZNF583 CDKN2B PCGF2 ATAD2 RYBP CAMK4 MAPK14 AGRP ZNF697 ZFP28 ZNF573 CSF2 AKT1 ZNF274;ZNF74 ZFP30 ZNF567 ZNF445 PITX2 ZNF202 ZNF160;ZNF347;ZNF665-1 MSX2 LIFR RBX1 FOXP3 APOE NRBP1 PCK1 ITCH PVALB ZNF793 ZNF791 KRBA1 ZNF546 ZKSCAN5 ZNF664 ZFHX3 SMAD4 AUTS2 ESRRB IL2 CDK6 ZNF426-1 ZNF771 LDB1 DGCR8 MYBL2 ZNF641 RBM14 ZNF75A CAMK2B ELL CAMK2D COX7C TAF7L CAMK2A INS;INS-IGF2 ZNF746 E2F6 CAMK2G ZNF740 POLR2G ZNF747;ZNF764 ZNF184 KCNIP3 MGA TBX5 TAF12 ZNF614 TAF13 TAF11 SSRP1 GTF2F1 TAF7 TAF5 TAF2 ARNT2 PPP2R5C COX6C JAG1 COX6A1 COX6A2 HNF4A G6PD TNRC6A-1 BRD2 KCTD1 KCTD15 FZR1 UBE2C CDKN2A CDC26 ANAPC1 ANAPC10 ANAPC11 AKT2 AKT3 SNRPF IRAK1 SNRPE-2 SNRPG-2 PTPN11 CASP1 TCF7L1 CCNE1 MYB TSC2 GATA1 NOTCH3 JUN STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation FLT3 PTPN11 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME GGT1 GSTT1 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 NUP88 SEC13 NUP133 EIF4E NUP205 NUP107 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 PCBP4 ZNF385A FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) ASF1A H1-3 H1-2 H1-5 HMGA2 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBAP1 MVB12A TSG101 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 NTHL1 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes MAPK1 INS;INS-IGF2 ARNT2 MDM2-2 BDNF ARNT CDK5 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTLA4 MAP3K14 MLST8 MAPKAP1 AKT2 AKT3 TRIB3 PIK3CG PIK3R1 MAP3K8 PIK3R5 AKT1 CDC42 PPP2R5E SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis RPL35 RPL38 RPL39 SECISBP2 RPL22 RPL18 RPL29 RPL7A RPS25 RPS27 EEFSEC RPS29 SEPHS2 FAU RPS21 RPS24 RPL37A-1 SEPSECS RPS15 RPS11 RPS13 RPL4 RPL30 RPL31 RPL6 RPL7 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis MAPK1 CTSG RNF213-2 NOS2 VPS33B ATP6V1H ENO1 CORO1A SFPQ-1 RAB7A MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHA ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation BMP1 TLL1 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle NIPSNAP2 PREX1 CDC42EP1 OPHN1 FNBP1 WAS DIAPH3 STOM GIT1 IQGAP3 CPNE8 CDC42BPA RAB7A PIK3R1 CDC42 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 MDM2-2 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 COP1 PSMC2-1 PHF20 PSMA7 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus NUP85 NUP88 SEC13 POP7 NUP133 POP1 POP4 RPP40 RTCB RPP21 C2orf49 RPP14 RTRAF NUP205 NUP107 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions PRNP CACNA1I GDNF COL4A5 CACNA1H COL4A4 COL6A3 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 FGF19 KLB INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling INS;INS-IGF2 ATP6V0A4 ATP6V1F ATP6V0D2 ATP6V1A ATP6V1H ATP6AP1 TCIRG1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 FGF19 PTPN11 FRS2 PIK3R1 KLB GAB1 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSMA6 PSMB1 PSMA7 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling FOXP3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion YRDC MTO1 TRMT61B HSD17B10 TRMT10C PRORP REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle MFN1 MFN2 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport TRAPPC4 TRAPPC10 SEC13 TRAPPC6A TRAPPC6B PREB GOLGA2 SEC31A AREG ANKRD28 PPP6C SEC23IP RAB1B GORASP1 LMAN2 CSNK1D SEC22C SEC22B MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle CCNE1 PTK6 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase CCNA1 ANKRD28 PPP6C RTEL1 DKC1 TERF2IP TERF2 PIF1 RUVBL2 NOP10 RUVBL1 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) MYD88 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate ETHE1 SLC25A10 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PRICKLE1 PSMD8 PSMA6 PSMD12 PSMD11 FZD4 FZD7 WNT5A PSMB1 PSMC2-1 VANGL2 PSMA7 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism NEU3 ARSJ NEU1 PSAP ARSH ORMDL1 ARSI B4GALNT1 KDSR ASAH1 CTSA M6PR SGMS2 B4GALT6 ACER3 CERK ST3GAL3 SGPP2 UGT8 MFSD2B CERS3 CERS6 ST6GALNAC5 CERS1 CERS2 SPHK1 HEXB SMPD1 A4GALT DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance EPHA5 ANK2 SHTN1 DOK6 SCN8A SPTBN4 L1CAM RGMB SPTB RGMA RHOA DSCAML1 DOK1 RELN ABLIM3 CAP2 CDK5 DOCK1 MYO10 TRPC6 RDX CFL1 PSMD8 PSMA6 EPHA4 PSMD12 PSMD11 DCC UNC5C MYH9 PSMB1 PSMC2-1 PSMA7 MAP2K2;MAP2K1 MAPK1 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 RPL35 RPL38 RPL39 SLIT3 RBX1 PRKACB-1 RPL22 PRKAR2A CNTN6 ANK1 RPL29 LDB1 PSEN2 APH1A ITGAV PSENEN AKAP5 SEMA5A AP2A1 AP2A2 RANBP9 CACNA1H MSI1 GSPT1 SLIT1 HOXA2 LHX2 COL4A5 GDNF RPL18 ETF1 PLXND1 FRS2 COL4A4 PIK3R1 COL6A3 CSNK2B CSNK2A1;CSNK2A3 EGFR RPL37A-1 RPS15 RPS11 RPS13 PLXNA1 ABL2 SRGAP2 MYH10 SRGAP1 ARPC4 PTK2 ACTR3-1 IRS2 PPP3CB SPTAN1 MMP9 GIT1 SEMA7A ARHGEF11 ACTR2 CRMP1 DPYSL5 DPYSL2 RPL7A DPYSL3 PLXNA2 PTPN11 PLXNB3 RPS25 RPS27 RPS29 EVL FAU RPS21 RPS24 GAB1 PRNP CACNA1I SH3KBP1 SCN11A EPHB1 EPHB4 EPHB3 CDC42 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins PCGF2 SUMO1 CBX4 BMI1 PHC3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization PECAM1 DDR1 SGCD SGCA SGCB COL4A5 TNN SNTA1 MATN1 FBN2 LAMA2 LRP4 FBLN5 ITGB4 DTNA LOXL3 LAMB2 LOXL1 MFAP5 COL4A4 SSPN PXDN SNTB1 SERPINH1 FBN1 COL6A3 SNTB2 PPIB PLEC ACTN1 ICAM5 COL17A1 COL18A1 COL15A1 TMPRSS6 COL12A1 PLG MMP20 SDC3 ACAN CAPN9 SCUBE1 ADAMTS1 CAPN7 CASP3 SPOCK3 CTSG MMP7 CMA1 MMP1 MMP9 MMP10 MMP12 ADAM17 PRSS3;PRSS2;PRSS1 ITGAM BMP1 CAPN10 MMP17 MMP19 TLL1 KLKB1 TRAPPC4 KDR ITGAV TGFB2 FGB FGA FGG CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance POLR2L STN1 DSCC1 MIS18A RSF1 POLD4 RFC1 H2BC15;H2BC3;H2BC11;H2BC12 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA WRN RPA2 RPA3 POLR2G ATRX DKC1 TERF2IP CENPA TERF2 RUVBL2 NOP10 RUVBL1 NPM1-2 CCNA1 ANKRD28 RTEL1 PPP6C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PIF1 RBBP7 CENPI CENPM TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade PPP2R5D UBE2V1 NOD1 IRAK1 S100A1 BIRC2 BIRC3 ITGAM MEF2C LY86 PTPN11 MAP3K8 LY96 RIPK1 TRAF2 PLCG2 TLR4 S100A9 TAB2 UBE2D3;UBE2D2 MAP2K2;MAP2K1 TBK1 MAPK1 FGB FGA BTK BTRC ECSIT RIPK2 FGG USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC2 EXOSC1 DIS3 EXOSC6 EXOSC4 EXOSC9 EXOSC8 AKT1 DCP2-1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism PLEKHA6 PTPN13 SLC44A2 PITPNB CPNE6 RAB14 PLA2G3 PGS1 PTDSS2 GPAT4 PTPMT1 CPNE3 GPAT2 CHKB DGAT2 MBOAT7 STARD10 PLAAT3 GPCPD1 CRLS1 ABHD3-2 HADHA PHOSPHO1 PIK3R1 ETNK2 LPCAT4 ETNK1 CSNK2B PNPLA3 CHPT1 CSNK2A1;CSNK2A3 LPIN1 MGLL PLA1A INPP4A PI4K2B PIK3R5 MTM1 INPP5F PIP4K2C PIK3R4 SYNJ1 PIK3CG PIK3C2B MTMR4 MTMR6 MTMR7 TNFAIP8L1 GDPD1 GDPD5 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SRPK1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function RDH12 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TBK1 NLRP4 TREX1 PRKDC CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC1 APOBEC2 ADAR ADARB1 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis F12 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception APOC3 CAPZA1 APOC2 RIPOR2 RDX CIB2 TRPM4 PJVK MYO7A EPS8 PCLO STRC CDH23 KCNMB1 XIRP2 OR8I2 OTOF GUCA1C KCNN2 OR52W1 TPRN TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 MYH9 OR2T1 PPEF1 OR5V1-2 TAS2R40 TAS2R41 OR52D1 OR2AG1;OR2AG2 OR1I1 APOB GRK7 OR51B6 OR8H2;OR8H3;OR8H1 OR10K2 OR51I2 OR2T29;OR2T5-3 OR5P3 OR51I1 TAS2R39 RPE65 CHRNA9 TAS2R7 TAS2R8 OR14J1 RDH8 OR10H1;OR10H5;OR10H2 OR4F21;OR4F16;OR4F29;OR4F3 OR7C1;OR7C2-9 TAS2R1 OR8D1 TAS2R4 APOE OR6C76 OR5M10;OR5M1-1 OR5P2-4 OR10A4 OR4A47-3 OR10A5 CLPS OR2G6 OR51F1 OR2A7;LOC107987545;OR2A4 OR4C11-1 OR12D3 OR8U8;OR8U1;OR8U9 TAS1R1 TAS1R3 RCVRN DHRS9 OR2T12;OR2T33;OR2T8-1 LDB1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 OR51E2 OR51M1 RETSAT OTOP1 NMT1 SLC17A8 LHX2 SCNN1G SCNN1D SCNN1B OPN1SW CALHM1 RDH12 SDC3 GPC3 GPC2 SPTAN1 GPC4 PDE6B PDE6A APOA2 APOA1 APOA4 ATP2B1 GNB1 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence MAPK1 TFDP1 MDM2-2 E2F2 TFDP2 CDKN2B CDK6 E2F3 CDKN2A CDKN2D CDKN2C TNRC6A-1 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 PPP3CB PRKACB-1 AKAP5 PRKAR2A RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib CDC37 ERBIN DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation ADAMTS20 MUC1 ADAMTSL5 DHDDS NEU1 THSD7A MUC4 MUC21 SDC3 ACAN ADAMTS1 CTSA GPC3 GFPT1 GPC2 GPC4 ST3GAL3 PGM1 GALM-2 ALG8 ALG3 GNE HEXB SLC26A2 CSPG5 SEMA5A MUC5B CFP THBS2 NOTCH3 THSD4 ADAMTS10 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins ISCU DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot S100A10 SERPINE2 PLG PLAU PLAT SERPINB8 SERPINB6-2 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic BICD1 PAFAH1B2 DCTN1 BICD2 DYNC1H1 ACTR10 DYNC1I2 DCTN2 CAPZA1 ACTR1A LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs TNRC6A-1 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS GPC3 GPC2 GPC4 SDC3 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism GADL1 NAT8L ASPA FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex POLR2L COPS7B COPS7A GTF2H3 POLR2G RBX1 DDB1 COPS8 USP7 ISY1;ISY1-RAB43 ERCC3 XAB2 GTF2H2C;GTF2H2C_2;GTF2H2 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway PPP2R5B MAPK1 PPP2R5A PPP2R5D PPP2R5C PTPN7 DUSP10 MAP2K2;MAP2K1 PPP2R5E SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells PLCG2 IL34 CBL PTPN11 PIK3R1 DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle ASL NMRAL1 NAGS SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DPH5 DPH6 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC MUC1 MUC4 MUC21 MUC5B MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity BACH1 HM13 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants CTBP1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism FADS2 HSD17B4 ELOVL5 ELOVL1 FADS1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System KLC2 FBXL19 RACGAP1 KLHL2 FBXL16 FBXL14 KLHL20 SPSB2 SPSB1 EPAS1 UBOX5 MKRN1 ASB7 KIF18A BLMH TRIM37 RNF220 CAPZA1 KIF2C ITK HLA-DPB1-1 HLA-DPA1 PPL SEC61A2 CD207 SEC22B RAB7A LY96 TLR4 CDC34 UBE2D3;UBE2D2 IL21 MYH9 CD84 LOC102723996;ICOSLG RAP1A AFF4 TNFSF13B MAPKAP1 CTSH CTSF HLA-DOA POLH MLLT3 SUPT6H SH2D1A APEX2 ACTR10 PRKAG3 PDCD1LG2 MAP3K14 EXO1 MLST8 RFC5 RFC3 RFC4 RFC2 PCNA BTN1A1 E2F7 E2F8 PLCG2 ITGAV LGMN PRKAG2 RFC1 STIM1 ORAI2 CSNK2B CSNK2A1;CSNK2A3 PRKCB DYNC1I2 CYBB KLRB1-1 DCTN2 CYBA CRTAM SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 ICAM5 LILRA5-4 ACTR1A PVR CD1A BTK TREML1 BTRC LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 JAML SIGLEC1 DYNC1H1 RAET1E-1 NECTIN2 CD99 ICOS ERLIN1 ERLIN2 BRD4 S100A1 PIK3CG CTNNBL1 E2F2 EVL WAS NCOA6 CTR9 SEC31A CSK SH3KBP1 RBBP6 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 BATF MAF BLNK DCTN1 MIB2 AHCYL1 EZH2 MAP3K8 S100A9 PSMD8 PSMA6 CTLA4 PSMD12 TEAD2 PSMD11 TEAD3 TEAD4 PSMB1 CTNNB1 PSMC2-1 PSMA7 MAD2L2 REV1 TRIB3 DIS3 EXOSC6 EXOSC4 EXOSC9 EXOSC8 AKT1 PIK3R5 EXOSC2 EXOSC1 RBX1 PRKACB-1 ITCH CTSA ELL TAF7L POLR2G REL SEC13 PTPRJ SIPA1 RAP1GAP2 NFKBIE TAF12 PTPN22 TAF13 TAF11 SSRP1 GTF2F1 FGB FGA TAF7 TAF5 ERAP1 TAF2 FGG UBA7 AP2A1 AP2A2 XDH PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C MPHOSPH6 PIK3R1 TNRC6A-1 FZR1 UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 MAGT1 AKT2 AKT3 CR2 CD3G JAK1 RIPK2 MYD88 TMEM258 DAD1 UBE2V1 RPN2 RPN1 PIK3R4 AP1S3 PPP3CB HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PTPN11 TAB2 UBE2D4 FBXO21 STT3B DCAF1 HERC2 TRIM21 UNKL FBXO7 FBXW8 KCTD7 RNF126 FBXW4 RNF138-1 BTLA UBE2R2 RNF213-2 UBA6 RNF6 RCHY1 TCF7L1 ASB16 MYB UBE2J1 FBXL20 HECTD1 BTBD1 HECTD3 LONRF1 UBE2B KLHL25 JUN CDC42 RNF25 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases RIPK1 RIPK2 RHOA DDX58 OTUD5 NOD1 ZRANB1 OTUB1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement COLEC10 C1QB MASP1 C1R C1QC CFD CFB CRP MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction CACNA1H SCN8A NPPC TMOD3 STIM1 ORAI2 ATP1B1 AHCYL1 KCNK9 ATP1A1 HIPK1 CAMK2B CAMK2D CAMK2A CAMK2G NKX2-5 KCNIP3 TPM3 TBX5 ATP1B3-1 KCNK6 ATP2B2 FXYD2;FXYD6-FXYD2 KCNK7 ATP2B1 SLC8A1 SLC8A2 KCNE5 CACNA1I MYL6B TNNI3 MYBPC3 TMOD1 MYL4 MYL7 KCNK10 TTN-1 TNNT2 KCNK2 KCNQ1 KCNK4 TNNT3 SCN11A RANGRF SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs PPP2R5D BDNF TRIB1 RHOA RAP1A CDK5 CRK GAB1 MAP2K2;MAP2K1 MAPK1 IRS2 EGR1 ID4 MAPK14 TPH1 IRS1 MEF2C PTPN11 AP2A1 FRS2 PIK3R1 AP2A2 RIT2 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery RPS27 RPS29 HNRNPA1-1 RPS11 RPS13 FAU RPS21 RPS24 RPS15 RPS25 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events CAMK2A MAPK1 CAMKK2 CAMK2G PDE1A PRKACB-1 CAMK4 PRKAR1A PRKAR2A CAMK2B CAMK2D AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors TAAR5 CHRM5 ADRA2A DRD4 HTR6 DRD5 HTR1A FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate POU5F1;POU5F1B NANOG;NANOGP8 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors PSIP1 NUP85 RCC1 NUP88 PSMD8 SEC13 RBX1 PSMA6 PSMD12 NUP133 PSMD11 PSMB1 AP1S3 PSMC2-1 PSMA7 NPM1-2 BTRC ATP6V1H HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NUP205 AP2A1 NUP107 AP2A2 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2L XPO5 BCDIN3D DICER1 POLR2G DGCR8 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins PDCD6IP MAP2K2;MAP2K1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response MAPK1 CASP3 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema F12 KLKB1 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function WRN BARD1 RBBP8 PALB2 EXO1 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription STRAP FOXA2 FOXP2 KLF9 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR FSHR TSHR GPHB5 RHOA DRD4 DRD5 CDK5 CCL3L1;CCL3L3;CCL3;CCL18 AHCYL1 PDE3B TRPC6 PDE11A PDE10A PDE1A TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 CAMKK2 MAPK1 C3AR1 NPY CAMK4 TAS2R39 AKT1 PIK3R5 TAS2R7 TAS2R8 TAS2R1 TAS2R4 PRKACB-1 GABBR2 SMO PRKAR1A PRKAR2A TAS1R1 TAS1R3 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 MCHR1 CAMK2B CAMK2D CAMK2A CAMK2G FFAR1 F2 RAMP2 GNAI2 HTR6 HTR1A TAAR5 PPP2R5D SCT RXFP1 RGS8 PLCB4 GPR37L1 DAGLA DGKB KEL CHRM5 CENPS-CORT;CORT;CENPS TAS2R42 MLN GIPR GPRC6A RGS2 GPR83 NPBWR1 BDKRB2 GALR1 BDKRB1 NPBWR2 GAST PROK1 GRK6 PRKCH WNT10B DGKZ OPN3 LTB4R2 PPP1R1B DGKK PNOC GPSM1 RGS17 GPR20 GRP LPAR1 GPER1 LPAR2 GRM8 LPAR3 GPSM3 LPAR4 PTGIR GPR35 PROKR1 GLP2R P2RY2 RAMP3 P2RY1 PIK3R1 TAC3 PTGER2 OPN4 PTGER3 NMB WNT8A CCL4L2;CCL4L1;CCL4 P2RY11 XCL1;XCL2 S1PR3 PREX1 RGS22 CCK LPAR5 S1PR2 NMS P2RY13 GPR55 FFAR3;GPR42 PRKCB MGLL WNT7A F2RL2 APLN GIP EGFR PDE7B ACKR1 RAMP1 AKT2 BTK AKT3 GNAZ CYSLTR1 OPN1SW PSAP ARRB1 RASGRF2 PPP3CB GNAT2 ARHGEF11 PIK3CG FZD4 FZD7 WNT5A ARHGEF15 FZD6 ARHGEF17 ADRA2A GNA14 CCL13;CCL2 GNB2 CCL22 CXCL8 AVPR1B GNB1 CCL20 ACKR4 CXCL5;CXCL6 GNB4 CDC42 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress EIF2S2 EIF2S3;EIF2S3B PHB2 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation MAPK1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling ARPC4 PTK2 ACTR2 RHOA ACTR3-1 CFL1 CDC42 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis AJUBA MED16 MED17 LPIN1 PHLDA1 MGLL CIDEC CDK8 NCOA6 H2BC15;H2BC3;H2BC11;H2BC12 ELOVL5 FABP4 MED23 CDK5 MED24 PLIN2 SCD MED31-1 DGAT2 CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1B TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation PTGDS AMH ZFPM2 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation MTX2 DNAJC11 HSPA9 IMMT MICOS10 ATP5MC1 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 RIPK1 UBE2V1 TLR4 UBE2D3;UBE2D2 BIRC2 BIRC3 LY96 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs SNRPF SNRPE-2 SNRPG-2 ZNF473 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA PSIP1 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry SDC3 GPC3 UBA6 GPC2 GPC4 LY6E CLDN1 UBA7 AP2A1 MAPRE3 PIK3R1 AP2A2 TYRO3 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell ADAM17 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 CCNB1 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) DPPA4 TPRX1;RAX2 DUX4;DUXA TEAD4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation MED16 MED17 THRAP3 CDK8 PCK1 NCOA6 SLC2A4 TNF FABP4 MED28-1 KLF5 MED8 MED23 MED24 WNT10B MED31-1 CCNC-1 TGS1 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSEN2 APH1A PSENEN DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism MGLL PRKACB-1 PPP1CC PNPLA4 FABP4 FABP3 FABP5 ABHD5 FABP6 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) ITGAV CYBB CYBA SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response CASP3 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade NMT1 GRK7 RCVRN PDE6B GUCA1C PDE6A GNB1 PPEF1 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling BDNF MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) WRN RTEL1 BARD1 RBBP8 PALB2 EXO1 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection POLR2L GTF2H3 RBX1 AP1S3 ERCC3 ATP6V1H HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NUP205 NUP107 TSG101 ELL TAF7L PSIP1 NUP85 MVB12A RCC1 NUP88 PSMD8 POLR2G SEC13 PSMA6 PDCD6IP PSMD12 NUP133 PSMD11 XRCC4 TAF12 TAF13 PSMB1 TAF11 SSRP1 GTF2F1 PSMC2-1 PSMA7 CHMP2B NMT1 UBAP1 GTF2H2C;GTF2H2C_2;GTF2H2 NPM1-2 BTRC CHMP3 TAF7 TAF5 CHMP6 TAF2 AP2A1 AP2A2 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System FBXL19 KLHL2 FBXL16 FBXL14 KLHL20 SPSB2 SPSB1 UBOX5 EPAS1 MKRN1 CBL ASB7 RHOA BLMH TRIM37 RNF220 CRK DOCK1 GSDME MYO10 MYO5A PPL PKP1 LY96 GSDMD RIPK1 TRAF2 TLR4 CDC34 UBE2D3;UBE2D2 FLT3 RAP1A MAP2K2;MAP2K1 FRK MAPK1 C3AR1 APOB EIF4E LRRC7 GNS PLCG2 ITGAV TCN1 LGMN GPI PYGB PRKAG2 PYGL ECSIT RFC1 ASAH1 EIF3C;EIF3CL EIF3L EIF3E EIF3B FABP5 NANOG;NANOGP8 ACLY IL33 EGR1 BIN2 ICOS PSAP KPNA4-1 ERLIN1 ERLIN2 IP6K2 BRD4 HPSE S100A1 PIK3CG EIF4G3 CTNNBL1 PGM2 UNC93B1 PGM1 E2F2 IL1R1 CTR9 SEC31A SH3KBP1 PTPN13 CGAS RAB14 GBP2;GBP3;GBP1 BLNK DYNLT1 DCTN1 AHCYL1 SERPINB1 TALDO1 MAD2L2 REV1 TRIB3 HSP90B1 PRKDC MAOA MGST1 PIK3R5 NEU1 CTSA DERA RAB27A GAA AMPD3 AGL-1 ERAP1 POLR3A POLR3D POLR3F POLR3K XDH MPHOSPH6 HSPA9 IDH1 MAN2B1 C1QB CPB2 CR2 C7 C1R C9 C1QC CA1 CPN1 PKM ANPEP EBI3 CRLF1 PDXK CNPY3 PYCARD P2RX7 AIM2 CASP1 SUGT1 HGF BTLA LOC105377022;FANCB TCF7L1 MYB CCL22 CXCL8 CCL20 ILF3 CDC42 KLC2 RACGAP1 SH2B3 RBSN KIF18A CAPZA1 KIF2C ITK EIF2S2 EIF2S3;EIF2S3B HLA-DPB1-1 HLA-DPA1 SEC61A2 NOS2 CD207 ATP6V1H SEC22B RAB7A SOD2 CFL1 HNRNPA2B1 PDCD4 IL12B SNRPA1 IL12A IL12RB1 IL12RB2 IL21 MYH9 CD84 LOC102723996;ICOSLG AFF4 TNFSF13B MAPKAP1 CTSH CTSF HLA-DOA NPM1-2 POLH MLLT3 SUPT6H SH2D1A APEX2 ACTR10 ATG5 FANCC PIN1 PRKAG3 PDCD1LG2 MAP3K14 TNFRSF13B TNFSF15 TNFRSF9 EXO1 EDA2R MLST8 CASP2 LTA TNFSF9 RFC5 RFC3 RFC4 RFC2 PCNA BTN1A1 E2F7 E2F8 PML LAMTOR2 MT2A SUMO1 DSP PECAM1 SLC44A2 CKAP4 STIM1 ORAI2 CPNE3 FCER2 IL21R WIPF3 CSNK2B CSNK2A1;CSNK2A3 PRKCB DYNC1I2 KLRB1-1 CYBB DCTN2 CYBA CRTAM SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 ICAM5 LILRA5-4 ACTR1A PVR CD1A TREML1 BTK LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 BTRC JAML SIGLEC1 RAET1E-1 DYNC1H1 IQGAP2 NECTIN2 CD99 ABL2 NCKAP1L ARPC4 PTK2 SIRPB1 ACTR3-1 NF2 CASP3 CTSG C1QBP MMP1 SPTAN1 MMP9 ADAM17 ACTR2 PRSS3;PRSS2;PRSS1 ITGAM TASL IRF5 LY86 KLKB1 RHOF EVL WAS NCOA6 STOM FLNA CSK RBBP6 WASF2 WASF3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ABI2 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2L IL13 H2BC15;H2BC3;H2BC11;H2BC12 TNF BATF MAF CCL3L1;CCL3L3;CCL3;CCL18 MIB2 EZH2 BIRC2 TNFRSF1A CHGA PGLYRP2 BIRC3 DEFB129 DEFB127 S100A7A;S100A7 MEF2C ATOX1 MAP3K8 ART1 BPIFB2 BPIFA1 PDZD11 NLRP4 REG3G;REG3A-1 TREX1 RNASE7 RNASE3;RNASE2-2 S100A9 ADAR PSMD8 PSMA6 CTLA4 PSMD12 TEAD2 PSMD11 TEAD3 TEAD4 PSMB1 CTNNB1 PSMC2-1 PSMA7 DIS3 MAPK14 EXOSC6 EXOSC4 EXOSC9 CSF2 EXOSC8 AKT1 EXOSC2 EXOSC1 RBX1 LIFR PRKACB-1 ITCH IL2 CFD CFB NUP205 PLAU NUP107 CAMK2B ELL SERPINB6-2 CAMK2D TAF7L CAMK2A NUP85 PAFAH1B2 CAMK2G NUP88 PTPN7 POLR2G IL34 REL SEC13 PTPRJ SIPA1 NUP133 RAP1GAP2 NFKBIE TAF12 PTPN22 TAF13 OTUD5 TAF11 SSRP1 GTF2F1 CRP FGB COLEC10 FGA TAF7 TAF5 F12 TAF2 HEXB FGG F2 UBA7 DDX58 MUC5B CFP AP2A1 AP2A2 PPP2R5E PPP2R5B PPP2R5A MUC1 PPP2R5D PPP2R5C MUC4 MUC21 IFIT3 ATP8A1 TCIRG1 ATP11B ATP6V0D2 ATP6V1A IRS1 PIK3R1 TNRC6A-1 ATP6V0A4 FZR1 UBE2C CDC26 ATP6V1F ANAPC1 ANAPC10 ANAPC11 ABCA13 MAGT1 IL20RA HP;HPR RPS15 TBK1 PA2G4 AKT2 TOLLIP AKT3 TRIM8 PLEKHO2 RPS11 SERPINB10 RPS13 JAK1 RNASEL CD3G IFNL2;IFNL3;IFNL1 RIPK2 IL10RB CARD9 USP14 SLCO4C1 NKIRAS1 CRLF2 NKIRAS2 PELI1 RAB3D ANO6 LAMP1 MYD88 GOLGA7-1 LAMP2 TYK2 IL13RA1 ILF2 TMEM258 RAB37 DAD1 CLEC4E RAB5C TLR7 ARL8A UBE2V1 PTPRB PTPN20 MASP1 SNAP29 TRIM62 RPN2 CANT1 PRCP RPN1 CPPED1 IL2RB FTH1 PIK3R4 TRIM38 AP1S3 NOD1 TRIM31 PTPN2 CSF2RA IFI35 IRAK1 DHX58 IL1R2 IRS2 SLPI CRISPLD2 PRLR TXK DHX36 PPP3CB VAT1 SIGLEC15 IFNLR1 PRG3 IL25 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ORM2;ORM1 IL15 PTPN11 IL19 OSMR CD63 RPS25 CAB39 RPS27 IL18R1 ENPP4 RPS29 RAG2 RAG1 IL17F IRAG2 DPP7 TAB2 UBE2D4 FAU ISG20 FBXO21 STT3B IL7R DCAF1 RPS21 IRF6 HERC2 RPS24 MS4A2 TRIM21 IL17A IRF9 UNKL GBP7;GBP4 FBXO7 TEC FBXW8 KCTD7 RNF126 FBXW4 RNF138-1 UBE2R2 RNF213-2 SPHK1 UBA6 RNF6 RCHY1 ASB16 UBE2J1 FBXL20 HECTD1 BTBD1 HECTD3 LONRF1 UBE2B KLHL25 JUN RNF25 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol ABCD3 SLC27A5 HSD17B4 CYP7A1 AMACR P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint BTRC PSMD8 PSMA6 RBX1 PSMD12 MAPK14 PSMD11 PSMB1 PSMC2-1 PSMA7 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer SNW1 JAG2 HDAC5 PSEN2 RBX1 MAMLD1 APH1A CDK8 PSENEN JAG1 HDAC1 MIB2 HES5 CCNC-1 ADAM17 MIB1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes PPIB COL4A5 COL17A1 COL18A1 COL15A1 COL12A1 BMP1 COL4A4 TLL1 SERPINH1 COL6A3 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER RPA3 XPC PIAS3 GTF2H3 PARP2 RBX1 SUMO1 RAD23A RAD23B DDB1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 RPA2 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway RIPK1 TRAF2 SHARPIN TAB2 BIRC2 TNFRSF1A BIRC3 TNF GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CAMK2A MDM2-2 CAMK2G CACNG3 PRKCB AKAP5 MYO6 AP2A1 CAMK2B CAMK2D TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHB GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation RIMS1 CPLX1 ALDH5A1 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) LTC4S REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate POLA2 RPA3 POLD4 PCNA RPA2 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling UBE2V1 PYCARD PLCG2 PSMD8 CDC34 TAB2 UBE2D3;UBE2D2 PSMA6 PSMD12 MAP3K14 PSMD11 PSMB1 PSMC2-1 PSMA7 BTRC PPP3CB AHCYL1 CARD9 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing ABHD17C ZDHHC9 GOLGA7-1 ABHD17B RCE1 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage ASCC1 ASCC2 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle RACGAP1 MCAM ERBIN DIAPH3 LEMD3 DOCK1 EMD GIT1 RAB7A PIK3R1 LBR PREX1 ARHGAP42 BAIAP2L1 CDC42EP1 OPHN1 CYBB CYBA NHS BCR SLITRK5 ARHGAP17 WASF2 ABI2 CDC42 NCKAP1L TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 MAPK1 INS;INS-IGF2 ARNT2 MDM2-2 BDNF KCNIP3 ARNT NR3C1 CDK5 TNRC6A-1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules SULT4A1 PODXL2 BPNT1 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions TLR7 UBE2V1 SNRPF MASP1 PIK3R4 DDX20 NOD1 IRAK1 VPS11 SNRPE-2 SNRPG-2 VPS16 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NUP205 PTPN11 NUP107 MPP5 RPS25 RPS27 NUP85 RPS29 NUP88 IL17F TAB2 SEC13 FAU NUP133 RPS21 RPS24 IL17A GEMIN2 RPS15 TBK1 AKT2 AKT3 RPS11 RPS13 JAK1 RIPK2 VPS33A VPS33B SFTPD DDX58 TYK2 AKT1 TUFM MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation PPA2 AARS2 PARS2 YARS2 EARS2 WARS2 GARS1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation LIPT1 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2A DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis MAPKAP1 RIPK1 PIK3R4 MLST8 TAOK1 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis FGB FGA F10 F11 FGG F2 F9 ANO6 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 TFDP1 TFDP2 HDAC1 LIN52 MYBL2 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR6 HTR1A SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer JAG2 MIB2 ADAM17 JAG1 MIB1 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism ADAMTS20 MUC1 ADAMTSL5 DHDDS THSD7A MUC4 MMAB MUC21 BCKDK NAGS GGT1 GFPT1 MTR-1 IDH1 GALM-2 NMRAL1 TALDO1 PPP1R3C BTD GNE PC OPLAH MAOA SLC26A2 SFTPD HIBCH BCKDHB NEU1 LMBRD1 ASL SDC3 ACAN ADAMTS1 CTSA CSF2RA G6PC1 GPC3 GPC2 NHLRC1 GPC4 ST3GAL3 CD320 GNS SLC37A4 PGM1 CYP11B1;CYP11B2 AUH TCN2 GAA ALG8 ALG3 CYP7B1 ADA AHCY HEXB CSPG5 SEMA5A PPM1K MUC5B CFP THBS2 NOTCH3 THSD4 ADAMTS10 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS MAPK14 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids GLYATL3 ACSM5 ACSM4 GLYAT POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins PRSS41 OTOA XPNPEP2 RTN4RL1 LY6D PIGK LY6G6C CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 PIGG TECTA;TBCEL-TECTA GPLD1 FOLR2 LY6E PIGS TECTB NRN1 RTN4RL2 IZUMO1R MSLN ALPG;ALPP;ALPI-1 PIGV DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC6A5 SLC6A2 SLC17A8 SLC25A18 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors P2RY11 P2RY13 LPAR4 P2RY2 P2RY1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 RIPK1 DDX58 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation MAPK1 AR UCMA MAF SATB2 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane RPL35 RPL38 RPL39 SRP68 RPL22 SRP9 RPL18 RPL29 SEC61A2 RPL7A RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 RPL31 RPL6 RPL7 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection NUP85 MVB12A NUP88 SEC13 NUP133 EGFR DYNC1I2 H2BC15;H2BC3;H2BC11;H2BC12 VPS25 CHMP2B UBAP1 CHMP3 DYNC1H1 CHMP6 EZH2 CHMP1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 NUP205 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP107 TSG101 PML MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres ITGAV FBLN5 MFAP5 TGFB2 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation MAPKAP1 MDM2-2 AKT2 AKT3 PPP2R5C CCNA1 RFFL MLST8 USP7 AKT1 PHF20 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism GDA XDH MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades PPP2R5B TEK PPP2R5A PPP2R5D PPP2R5C RANBP9 SPTBN4 SPTB PHB RASGEF1A ETV4 MAPK4 GDNF KIT IRS1 FRS2 PIK3R1 TNRC6A-1 PSMD8 PSMA6 PPP1CC PSMD12 EGFR PSMD11 FLT3 PSMB1 PSMC2-1 RAP1A KLB PSMA7 MAP2K2;MAP2K1 MAPK1 JAK1 FGF19 GOLGA7-1 CSF2 TYK2 ARRB1 RBX1 PTK2 PRKACB-1 IL2RB APBB1IP MRAS CSF2RA MAP3K11 RASGRF2 LRRC7 IRS2 DAB2IP SPTAN1 RASAL3 IL2 SPRED3 SPRED2 SPRED1 RASA4;RASA4B NF1 DUSP10 PTPN11 CAMK2B KSR2 CAMK2D CAMK2A ZDHHC9 RAG2 LAMTOR2 RAG1 CAMK2G PTPN7 HGF ABHD17B RCE1 AREG FGB ABHD17C FGA CSK FGF7 FGF22 FGG PPP2R5E CDC42 JUN CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 PPP2R5B AKT2 PPP2R5A AKT3 PPP2R5D PPP2R5C CTLA4 PTPN11 AKT1 PPP2R5E METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation POLA2 STN1 TERF2IP TERF2 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation ADAMTS20 MUC1 ADAMTSL5 THSD7A MUC4 ST6GALNAC3 MUC21 ADAMTS1 SLC35A1 B4GALT6 SLC35A4 FKRP GALNT14 ST3GAL4 CRPPA GALNT9;GALNT17 LARGE2 GALNT16 FKTN GALNT15 GCNT1 GALNT10 POFUT2 ST3GAL1 GALNT9 ST3GAL3 B3GNT6 POMK B3GNT2 ST6GAL1 SEMA5A MUC5B CFP THBS2 THSD4 ADAMTS10 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1;POU5F1B NANOG;NANOGP8 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNB2 KCNJ3 KCNJ5 GABBR2 KCNJ10 GNB1 GNB4 KCNJ15 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome BTRC PSMD8 PSMA6 RBX1 PRKACB-1 PSMD12 ITCH PSMD11 PSMB1 PSMC2-1 PSMA7 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition RPS27 RPS29 FAU RPS21 RPS24 RPS15 EIF3C;EIF3CL RPS11 EIF3L RPS13 EIF2S2 EIF3E EIF2S3;EIF2S3B EIF3B EIF4E EIF4B RPS25 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA CNOT9 PABPC1;PABPC3 EIF4E EIF4B CNOT6 CNOT7 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism SLC9A1 HEXB HYAL3 CEMIP CHP1 HMMR HAS3 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation KLC2 POLR2L RACGAP1 MPHOSPH6 RFC1 KIF18A BATF CAPZA1 MAF KIF2C DCTN1 HLA-DPB1-1 HLA-DPA1 RAB7A DYNC1I2 DCTN2 IL21 MYH9 CD84 LOC102723996;ICOSLG AFF4 ACTR1A TNFSF13B CTSH CTSF HLA-DOA MAD2L2 POLH CR2 REV1 MLLT3 SUPT6H DYNC1H1 SH2D1A DIS3 APEX2 ACTR10 EXOSC6 EXOSC4 EXOSC9 EXOSC8 EXOSC2 EXOSC1 ICOS EXO1 CTSA RFC5 RFC3 RFC4 RFC2 PCNA E2F7 E2F8 CTNNBL1 ELL TAF7L E2F2 POLR2G NCOA6 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CTR9 TAF7 TAF5 TAF2 MYB BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA CRAT HSD17B4 AMACR NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions ANK1 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade PPP2R5B TEK PPP2R5A PPP2R5D PPP2R5C RANBP9 SPTBN4 SPTB PHB RASGEF1A GDNF KIT IRS1 FRS2 PIK3R1 PSMD8 PSMA6 PPP1CC PSMD12 EGFR PSMD11 FLT3 PSMB1 PSMC2-1 RAP1A KLB PSMA7 MAP2K2;MAP2K1 MAPK1 JAK1 FGF19 GOLGA7-1 CSF2 ARRB1 RBX1 PTK2 IL2RB APBB1IP MRAS CSF2RA MAP3K11 RASGRF2 LRRC7 IRS2 DAB2IP SPTAN1 RASAL3 IL2 SPRED3 SPRED2 SPRED1 RASA4;RASA4B NF1 DUSP10 CAMK2B KSR2 CAMK2D CAMK2A ZDHHC9 LAMTOR2 CAMK2G PTPN7 HGF ABHD17B RCE1 AREG FGB ABHD17C FGA CSK FGF7 FGF22 FGG PPP2R5E METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA COMT LRTOMT GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization MAPK1 GORASP1 RAB1B CCNB2 GOLGA2 CCNB1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling UBE2V1 PTPN20 RBX1 IL13 PTPN13 NOD1 PTPN2 IRAK1 CTSG IL1R2 PTPN11 MAP3K8 IL18R1 GSDMD TRAF2 PTPN7 PSMD8 TAB2 CASP1 PSMA6 PSMD12 PSMD11 IL1R1 PSMB1 PSMC2-1 PSMA7 MAP2K2;MAP2K1 TBK1 TOLLIP BTRC IL33 RIPK2 USP14 NKIRAS1 NKIRAS2 PELI1 MYD88 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors MDM2-2 MITF PIAS3 SUMO1 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC TCN2 CD320 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A KIF2C WAPL NCAPG CSNK2B CSNK2A1;CSNK2A3 PPP1CC DYNC1I2 DCTN2 SSNA1 CEP164 CCNB2 ACTR1A CCNB1 TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 SKA1 CEP152 HAUS4 SKA2 CSNK1D HAUS5 TUBG1 NEDD1 NEK9 CENPJ NEK6 ALMS1 CEP63 TUBGCP5 AHCTF1 TUBGCP6 TUBGCP4 NUF2 NUDC NUP107 RPS27 NUP85 SEC13 NUP133 CENPA NSL1 SMC3 CENPF STAG2 CENPI TAOK1 CENPM PPP2R5E NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis GPC3 GPC2 GPC4 SDC3 XYLT2 CSPG5 FAM20B C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) MUC1 CLEC4E UBE2V1 PYCARD PLCG2 MUC4 PSMD8 CDC34 TAB2 MUC21 UBE2D3;UBE2D2 PSMA6 PRKACB-1 PSMD12 MAP3K14 PSMD11 PSMB1 PSMC2-1 PSMA7 BTRC PPP3CB AHCYL1 CARD9 MUC5B GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPL35 RPL38 RPL39 RPL22 RPL18 EIF3C;EIF3CL EIF3L EIF2S2 EIF3E EIF2S3;EIF2S3B RPL29 EIF3B RPL7A EIF5B RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 RPL31 EIF4E EIF4B RPL6 RPL7 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPS27 RPL35 RPS29 RPL38 RPL39 FAU RPS21 RPS24 RPL22 RPL37A-1 RPS15 RPL18 RPS11 RPS13 RPL4 RPL30 RPL29 RPL31 RPL7A RPL6 RPL7 RPS25 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi ST3GAL4 ST3GAL6 ST3GAL3 NOTCH3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes LMBRD1 PRSS3;PRSS2;PRSS1 TCN1 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA MECR HADHA GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors F10 F2 F9 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC27A5 STARD5 SLC10A2 FABP6 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR POLR2L POLR2G CBL GTF2F1 KLB GAB1 MAPK1 ESRP1 FGF7 HNRNPA1-1 FGF22 FGF19 SPRED2 SPRED1 PTPN11 FRS2 FGFRL1 PIK3R1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R5E REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases ASCC1 ASCC2 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFRSF1A TNFRSF13B TNFSF15 TNFRSF9 EDA2R LTA TNFSF9 TNFSF13B SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PLXNA2 PLXNA1 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions ERLIN2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB CAMK2A CAMKK2 CAMK2G CAMK4 CAMK2B CAMK2D MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition TFDP1 TFDP2 E2F3 PTK6 POLA2 PCNA CDK6 MYBL2 RPA2 RPA3 E2F2 E2F6 PSMD8 CDKN2A PSMA6 PSMD12 PSMD11 LIN52 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 CCNB1 PPP2R2A;PPP2R2D AKT2 AKT3 HDAC1 GMNN CDKN2B CCNA1 ORC1 ORC2 CCNE1 TYMS CDKN2D CDKN2C AKT1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF CAMK2A CAMK2G ARRB1 PHB APBB1IP MAP3K11 RAP1A MAP2K2;MAP2K1 FGB MAPK1 FGA CSK FGG CAMK2B CAMK2D KSR2 FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct PAX8 LHX1 HOXB4 ID4 HOXA6 CTNNB1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing POLR2L ESRP1 HNRNPA1-1 POLR2G GTF2F1 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses APOA1 CGAS CTR9 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RPL35 RPL38 RPL39 RPL22 GSPT1 RPL18 ETF1 RPL29 RPL7A SMG5 SMG6 RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 PPP2R2A;PPP2R2D RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors COQ8A GCH1 IDH1 COQ6 PDSS2 SPR AKT1 ACO1 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling MAPK1 CBL PTPN11 FRS2 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 GTF2F1 ERCC3 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models SOD2 CDK5 GOLGA2 JUN SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane MTM1 PIP4K2C PLEKHA6 PTPN13 RAB14 INPP4A SYNJ1 PI4K2B PIK3CG PIK3C2B PIK3R1 MTMR6 PIK3R5 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism BTD PC LMBRD1 MMAB TCN2 CD320 MTR-1 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection POLR2L RPL35 RPL38 RPL39 KPNA4-1 RPL22 GBP2;GBP3;GBP1 RPL18 RPL29 RPL7A NUP205 NUP107 RPS25 RPS27 NUP85 RPS29 NUP88 POLR2G SEC13 FAU NUP133 RPS21 RPS24 RPL37A-1 GTF2F1 RPS15 RPS11 RPS13 RPL4 RPL30 RPL31 PABPN1-1 RPL6 RPL7 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE UNC93B1 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 TGS1 NCOA6 CRTC1 MEF2C NRIP1 CRTC3 RAI1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints ATR RAD9A H2BC15;H2BC3;H2BC11;H2BC12 EXO1 RFC5 RFC3 RFC4 RFC2 WRN RBBP8 RPA2 PKMYT1 RPA3 PSMD8 PSMA6 PSMD12 PSMD11 HERC2 CDC45 MCM8 PSMB1 CCNB2 PSMC2-1 RHNO1 PSMA7 CCNB1 CCNA1 ORC1 CLSPN ORC2 BARD1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C CNEP1R1 SUMO1 H2BC15;H2BC3;H2BC11;H2BC12 KIF18A LEMD3 KIF2C WAPL GOLGA2 NCAPG MAU2 CSNK2B NCAPD3 CSNK2A1;CSNK2A3 PSMD8 UBE2C LPIN1 PRKCB PSMA6 CDC26 PPP1CC ANAPC1 PSMD12 DYNC1I2 PSMD11 ANAPC10 DCTN2 ANAPC11 SSNA1 CEP164 PSMB1 CCNB2 ACTR1A PSMC2-1 PSMA7 CCNB1 TUBA1A MAPK1 CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 SKA1 CEP152 HAUS4 SKA2 CSNK1D HAUS5 TUBG1 NEDD1 NEK9 CENPJ NEK6 ALMS1 CEP63 TUBGCP5 AHCTF1 TUBGCP6 TUBGCP4 NUF2 EMD RAB1B NUDC NUP205 NUP107 RPS27 LBR NUP85 RCC1 NUP88 SEC13 NUP133 CENPA NSL1 PPP2R2A;PPP2R2D CHMP2B TUBB2B;TUBB2A CHMP3 TUBAL3 CHMP6 GORASP1 SMC3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF STAG2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI TAOK1 CENPM PPP2R5E VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels KCNG1 KCNG2 KCNH6 KCNC1 KCNS2 KCNB1 KCNAB1 KCNS3 KCNAB3 KCNQ1 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination RPA3 RBBP8 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RPA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MLH3 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose NUDT14 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function PPP1CC MRAS MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins CSNK2B CSNK2A1;CSNK2A3 PPP1CC INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption SLC5A1-1 RSC1A1 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SV2A ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events CAMK2A LIN7C NRGN CAMK2G PRKAG3 PRKACB-1 PRKAR1A PRKAR2A GRIN3B GRIN3A RASGRF2 CAMKK2 LRRC7 MAPK1 PRKAG2 GIT1 CAMK4 CAMK2B CAMK2D GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation PDCD4 HSPA9 SNRPA1 CA1 TALDO1 CAPZA1 SOD2 CFL1 CDC42 HNRNPA2B1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E AP1S3 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R5E ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells KCNMB1 KCNN2 CHRNA9 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport TIMM21 NDUFA7 NDUFS8 NDUFA3 COX6C NDUFS3 NDUFS2 COA3 NDUFA12 TRAP1 COX6A1 COX6A2 SCO1 MDH1 SCO2 MDH2 SDHC NDUFAF2 UQCRC2 SDHB C12orf73 NDUFAF1 LYRM2 HIGD1A LYRM4 HSCB COX7C HSPA9 HIGD2A BCS1L SLC25A18 COX20 NDUFB8 NDUFB6 ECSIT TMEM186 SMIM4 NDUFB4 NDUFB2 NDUFB1 RAB5IF UQCRFS1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) ATR RAD9A POLD4 RFC1 MUS81 EME1-1 EME2 PALB2 SLX1A;SLX1B H2BC15;H2BC3;H2BC11;H2BC12 EXO1 RFC5 RFC3 RFC4 RFC2 PCNA WRN RBBP8 RPA2 RPA3 PPP4C HERC2 RHNO1 POLH CCNA1 CLSPN RTEL1 BARD1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation POLR2L AJUBA CNOT9 POLR2G RARA NCOA6 H2BC15;H2BC3;H2BC11;H2BC12 HOXA3 HOXB3 HOXB2 YY1 HOXB1 HOXA2 PCGF2 HOXB4 EZH2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CNOT6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUN MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling ALK MDK SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions CAMK2A ZC3HAV1 CAMK2G ARRB1 AP3B1 APBB1IP RAP1A MAP2K2;MAP2K1 FGB CLCN6 MAPK1 FGA ESRP1 CSK FGG AGTRAP CAMK2B CAMK2D KSR2 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants FZD4 FZD6 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling LRRC7 RASGRF2 CAMK2A MAPK1 CAMK2G CAMK2B CAMK2D NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways UBE2V1 PYCARD P2RX7 AIM2 TAB2 CASP1 SUGT1 ITCH NOD1 CASP2 IRAK1 BIRC2 RIPK2 CARD9 MAPK14 BIRC3 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs TBK1 NLRP4 RIPK1 NKIRAS1 NKIRAS2 MYD88 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis BCL2A1 HDAC1 DICER1 TNRC6A-1 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants FLT3 PTPN11 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines AEBP2 SETD1B SUV39H2 SETD3 EZH2 SETD7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KMT5B DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis ARRB1 AP1G2 BLOC1S1 DNAJC6 M6PR AP1S3 GNS RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 GLYAT CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway CAMK2A CTNNB1 PPP3CB TCF7L1 GNAT2 PDE6B GNB2 PDE6A FZD4 GNB1 WNT5A FZD6 GNB4 TNRC6A-1 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation PLCG2 PSMD8 PRKCB PSMA6 REL PSMD12 PSMD11 NFKBIE PSMB1 PSMC2-1 PSMA7 BLNK STIM1 BTK ORAI2 BTRC SH3KBP1 PPP3CB AHCYL1 PIK3R1 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM POLR2L POLR2G GTF2F1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2R5D PFKFB2 PRKACB-1 PFKFB1 PFKFB4 PFKFB3 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity SNW1 MAPK1 SMAD4 HDAC1 USP9X MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels KCNK9 KCNK10 KCNK2 KCNK4 KCNK6 KCNK7 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAPK1 JAK1 PTPN11 TYK2 MAP2K2;MAP2K1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions CLDN23-1 CLDN2 CLDN1 MPP5 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases MAPK1 S100A9 PRKCB MAPK14 NOXA1 NOX3 PIK3R4 CYBB CYBA PIN1 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability MAPKAP1 AKT2 AKT3 TRIB3 MLST8 CTNNB1 AKT1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein NEU3 DHDDS NEU1 ST3GAL6 ST6GALNAC3 NUDT14 ALG8 CTSA ALG3 SLC35A1 FCSK DOLPP1 NAGK GMPPA ST3GAL4 ST6GALNAC5 AMDHD2 GFPT1 RENBP GNE ST6GAL1 ST3GAL1 ST3GAL3 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism CRAT HIBCH BCKDHB AUH BCKDK GLYAT PPM1K HSD17B10 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants SNW1 JAG2 HDAC5 PSEN2 RBX1 MAMLD1 APH1A CDK8 PSENEN JAG1 HDAC1 MIB2 HES5 CCNC-1 ADAM17 MIB1 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase PTGES3-1 FKBP4 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations POMK DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) SNW1 HDAC5 KLF13 CBX4 MAMLD1 SATB1 MEN1 IL13 GATAD2A BMI1 PHC3 BATF YY1 MAF HDAC1 RBBP7 JUN MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 CHCHD1 MRPS28 PTCD3 MRPS23 MRPL49 MRPS2 MRPL47 MRPS7 MRPL43 MRPL21 LOC107987373;MRPL23 MRPL52 MTRF1L MRPS17 MRPS16 MRPS33 MRPL18 MRPL19 MRPS31 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia TFDP1 GMNN MYB DEUP1 MCIDAS GMNC TNRC6A-1 CCNO DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes SMAD4 PCBP4 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE ETNK1 CHKB LPIN1 PHOSPHO1 ETNK2 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic COG8 CYTH4 COG6 MAN1A1 RAB36 SNAP29 COG2 BET1L COG1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs CASP3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion SMC3 STAG2 WAPL FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling FGF7 FGF22 PTPN11 FRS2 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm NUP85 NUP88 DDX39B SEC13 THOC1 DHX38 NUP133 THOC3 THOC6 EIF4E NUP205 NUP107 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency CHAC1 PPP1R15A TRIB3 EIF2S2 EIF2S3;EIF2S3B VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs NUP85 PSIP1 NUP88 SEC13 NUP133 NUP205 NUP107 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation CAMK2A CAMK2G SCN8A SCN11A RANGRF CAMK2B CAMK2D NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia F10 F9 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 UBTF GTF2H3 TAF1D RRN3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ERCC3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDKN2A IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex UBE2V1 PELI1 IRAK1 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers NQO1 SNRPF SUMO1 GATAD2A PCK1 H2BC15;H2BC3;H2BC11;H2BC12 G6PC1 SF3B6 FAM124B PHF5A SNRPE-2 IGF2 CHD6 SNRPN SNRPG-2 AXIN2 CHERP PUF60 SNRPA1 MYOG SSRP1 CTNNB1 CTR9 MYOD1 HDAC1 TCF19 PWWP2B IKZF1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 ZMYND8-1 PWWP2A ADNP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma APOA1 HP;HPR HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC GPCPD1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling RBX1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation RPL35 RPL38 RPL39 RPL22 RPL18 EIF3C;EIF3CL EIF3L EIF4EBP1 EIF2B4 EIF2S2 EIF3E EIF2S3;EIF2S3B RPL29 EIF3B EIF2B1 RPL7A EIF5B RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 EIF4E EIF4B RPL6 RPL7 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification DAD1 CSNK2B CSNK2A1;CSNK2A3 PSMD8 ERLIN1 RBX1 PSMA6 RPN2 PDCD1LG2 ERLIN2 PRKAG3 STT3B PSMD12 PSMD11 RPN1 PSMB1 MAGT1 PSMC2-1 PSMA7 PRKAG2 BTRC MIB2 JAK1 TMEM258 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RHOA ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K BDNF PIK3R1 GAB1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins ANK1 ANK2 SCN8A SPTAN1 SPTBN4 L1CAM SPTB SCN11A RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle SRGAP2 STAM2 SPTAN1 GIT1 USP9X TXNL1 MYO6 PIK3R1 CDC42 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis CAMK2A CAMK2G ATP1B3-1 ATP2B2 FXYD2;FXYD6-FXYD2 ATP2B1 SLC8A1 SLC8A2 STIM1 ORAI2 ATP1B1 TNNI3 AHCYL1 ATP1A1 CAMK2B CAMK2D MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling TBK1 UBE2D3;UBE2D2 ITCH UBA7 DDX58 ATG5 OTUD5 PIN1 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation FGB FGA SERPINE2 FGG F2 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis CSPG5 CHSY3 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation HGF PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 FZR1 CCNB1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery POLR2L POLR2G SSRP1 GTF2F1 ELL ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects TFDP1 E2F2 TFDP2 CDK6 E2F3 CCNE1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade PLCG2 PIK3CG MPIG6B PDPN RHOA PTPN11 PIK3R1 PIK3R5 CDC42 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) TAS2R1 TAS2R4 GABBR2 TAS2R42 TAS2R3-1 TAS2R16 GPRC6A PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 TAS1R1 TAS1R3 GRM8 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 TAS2R39 TAS2R7 TAS2R8 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation GJC2 MYO6 GJB4 GJA9 GJA8 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 H2BC15;H2BC3;H2BC11;H2BC12 MCM8 PSMB1 PSMC2-1 PSMA7 GMNN ORC1 ORC2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription MAPK1 SMAD4 TFDP1 TFDP2 HDAC1 CDKN2B CCNC-1 MEN1 CDK8 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation JAK1 PTPN11 TYK2 MAP2K2;MAP2K1 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat POLR2L POLR2G GTF2F1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events MAPK14 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere RPA3 POLD4 PCNA WRN TERF2IP TERF2 RPA2 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency TCN2 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication TWNK POLG2 MGME1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation AP2A1 AP2A2 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis ARPC4 PTK2 WAS ACTR3-1 MYH9 CRK DOCK1 MAPK1 BTK WASF2 MYO10 CD3G WASF3 MYO5A ACTR2 ABI2 WIPF3 CDC42 NCKAP1L BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP2D6;LOC107987479;LOC107987478-1 LTC4S ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants ALK CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA NLRP4 POLR2L TREX1 RIPK1 AIM2 TRIM21 CGAS CTNNB1 TBK1 DHX36 POLR3A PRKDC POLR3D NKIRAS1 POLR3F NKIRAS2 POLR3K MYD88 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors GNB2 GNB1 GNB4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins TFDP1 AKT2 AKT3 TFDP2 AKT1 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 BDNF SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDKN2A TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation IARS1 SRP68 SRP9 GSPT1 RPL18 ETF1 EIF3C;EIF3CL EIF3L EIF4EBP1 EIF2B4 EIF2S2 EIF3E EIF2S3;EIF2S3B EIF3B EIF2B1 SEC61A2 MRPS17 MRPS16 EIF5B MRPS33 MRPL18 MRPL19 MRPS31 MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 PSMD8 CHCHD1 MRPS28 PSMA6 UBE2D3;UBE2D2 PTCD3 TSFM PSMD12 MRPS23 PSMD11 MRPL49 MRPS2 RPL37A-1 MRPL47 PSMB1 MRPS7 ASCC2 PSMC2-1 MRPL43 RPS15 PSMA7 MRPL21 PPA2 LOC107987373;MRPL23 MRPL52 MTRF1L RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 EIF4E EIF4B RPL6 RPL7 TUFM RPL35 RPL38 RPL39 RBX1 RPL22 AIMP1 RPL29 RPL7A RPS25 RPS27 TCF25 RPS29 FAU GARS1 RPS21 FARSA RPS24 YARS1 TARS1 VARS1 PPA1-1 EEF1G AARS2 PARS2 YARS2 EARS2 RCHY1 WARS2 TRMT112 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants FLT3 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling ZC3HAV1 ARRB1 AP3B1 PHB APBB1IP MRAS MAP3K11 ESRP1 SPRED3 SPRED2 SPRED1 NF1 DUSP10 CAMK2B CAMK2D KSR2 CAMK2A CAMK2G PPP1CC RAP1A MAP2K2;MAP2K1 MAPK1 FGB CLCN6 FGA CSK FGG AGTRAP SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses NUP85 TLR7 UBE2V1 IL17F NUP88 MASP1 TAB2 SEC13 NUP133 PIK3R4 IL17A NOD1 IRAK1 TBK1 JAK1 RIPK2 SFTPD HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E DDX58 NUP205 PTPN11 NUP107 TYK2 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DHDDS DOLPP1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGFR3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes IDH1 ME1 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin MAPK1 SMAD4 ACVR1B LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer SMAD4 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression NKX2-5 TBX5 TEAD2 TEAD3 TEAD4 HIPK1 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling IL2 JAK1 IL2RB DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis PAICS PPAT DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHBG SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer SMAD4 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells SMAD4 TDGF1 DPPA4 HIF3A EPAS1 POU5F1;POU5F1B NANOG;NANOGP8 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization NECTIN4 NECTIN2 NECTIN1 PVR ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans TNN MATN1 LAMA2 LRP4 ITGAV ACAN LAMB2 TGFB2 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis COPS7B SYT9 COPS7A SLC18A3 ARRB1 UBQLN2 IL7R SYT2 EGFR CBL COPS8 M6PR AREG STAM2 SH3KBP1 APOB PICALM EPS15 CD3G FZD4 WNT5A AP2A1 AP2A2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression CCNB1 MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation PNPT1 REXO2 LRPPRC PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors PTGIR PTGER2 PTGER3 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis CYP11B1;CYP11B2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria UBE2D3;UBE2D2 GBP2;GBP3;GBP1 EPCAM MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development IARS1 SUMO1 DCT PMEL EDIL3 ASAH1 BCL2A1 AIMP1 KIT MYO5A ATP6V1A ATP6V1H PXDN TNRC6A-1 CDH2 RAB27A CDKN2A STT3B TFEB CTNNB1 CCNB1 MAPK1 AKT2 AKT3 ALX3 HDAC1 MITF DICER1 TCF7L1 ZIC1 MAPK14 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF7 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants KREMEN1 DKK1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS TLR7 HMG20B RBX1 GATAD2A NR3C1 COMT BLNK BRD4 PTGES3-1 ATP1B1 ATP1A1 SIGMAR1 RIPK1 PLCG2 ATP1B3-1 IL1R1 FXYD2;FXYD6-FXYD2 SAP30 TBK1 BTK HDAC1 SH3KBP1 BRMS1 JAK1 CYSLTR1 SAP30L KDM1A RBBP7 AP2A1 AP2A2 PHF21A TYK2 FKBP4 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly SUMO1 GATAD2A PCK1 H2BC15;H2BC3;H2BC11;H2BC12 G6PC1 TCF19 HDAC1 PWWP2B IKZF1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 ZMYND8-1 PWWP2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants CDC37 ERBIN EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation RPL35 RPL38 RPL39 RPL22 RPL18 EIF3C;EIF3CL EIF3L EIF4EBP1 EIF2B4 EIF2S2 EIF3E EIF2S3;EIF2S3B RPL29 EIF3B EIF2B1 RPL7A EIF5B RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 EIF4E EIF4B RPL6 RPL7 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes G6PD TKT TALDO1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors KIT ATAD2 EGFR YY1 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol MPHOSPH6 RPL18 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 DIS3 RPL31 EXOSC6 CSNK1D EXOSC4 RPL6 EXOSC9 RPL7 EXOSC8 EXOSC2 RPL35 EXOSC1 RPL38 RPL39 RIOK2 GNL3 RPL22 EBNA1BP2 NIP7 ISG20L2 BYSL NOP58 RPL29 RPL7A UTP6 DDX49 UTP11 FCF1 WDR75 RPS25 NOC4L RPS27 IMP4 DDX52 RPS29 RRP9 RCL1 RRP7A PDCD11 FAU BMS1 RPS21 DCAF13 RPS24 UTP14C;UTP14A RPP40 RPP21 RPP14 XRN2 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling SLIT3 PTK2 RGMB RGMA DCC DSCAML1 UNC5C ABLIM3 SLIT1 DOCK1 MYO10 TRPC6 PTPN11 CDC42 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants FLT3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding CSNK2B CSNK2A1;CSNK2A3 FBXW4 TUBA1A TUBB2B;TUBB2A TUBAL3 SPHK1 GNA14 AP3M1 CCNE1 GNB2 XRN2 KIF13A GNB1 PDCL GNB4 CCT7 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes CEP63 DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER POLR2L RPA3 POLD4 RFC1 GTF2H3 POLR2G RBX1 DDB1 USP7 ISY1;ISY1-RAB43 RFC5 ERCC3 RFC3 RFC4 XAB2 GTF2H2C;GTF2H2C_2;GTF2H2 RFC2 PCNA RPA2 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions ANK2 CSNK2B SHTN1 RANBP9 SCN8A CSNK2A1;CSNK2A3 SPTBN4 L1CAM SPTB EGFR ITGAV CNTN6 MAP2K2;MAP2K1 ANK1 MAPK1 SPTAN1 DPYSL2 AP2A1 SCN11A RDX AP2A2 DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME HSD11B1 CYP2D6;LOC107987479;LOC107987478-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC28A2 SLC29A3 GLYATL3 PCK1 NME1 ADA PON3 GGT1 PON1 ADAL CES2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ACSM5 ACSM4 GLYAT GSTT1 XDH UGT2A1 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 SEC13 PPP1CC NUP133 DYNC1I2 CENPA NSL1 DYNC1H1 SKA1 SKA2 CENPF CENPI TAOK1 CENPM PPP2R5E COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding TUBA1A TUBB2B;TUBB2A TUBAL3 CCT7 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression TAF1D H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer AREG CDC37 EGFR CBL PIK3R1 GAB1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants KIT PIK3R1 CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic TFDP1 B9D2 TFDP2 CNEP1R1 E2F3 PTK6 KIF18A H2BC15;H2BC3;H2BC11;H2BC12 KIF2C GOLGA2 POLA2 NCAPG PKMYT1 MAU2 NCAPD3 PSMD8 PSMA6 PSMD12 PSMD11 GINS1 GINS2 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 MAPK1 CCNA1 CDKN2B AKT1 RBX1 RFC5 RFC3 LCMT1 RFC4 RFC2 PCNA CDK6 RAB1B MYBL2 NUP205 RPA2 NUP107 NUP85 RPA3 E2F6 RCC1 NUP88 SEC13 NUP133 PPP2R2A;PPP2R2D CHMP2B CHMP3 CHMP6 SMC3 TYMS STAG2 CDKN2D CDKN2C PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C POLD4 RFC1 SUMO1 LEMD3 WAPL CDK11A;CDK11B CSNK2B CSNK2A1;CSNK2A3 FZR1 UBE2C LPIN1 PRKCB CDKN2A CDC26 PPP1CC ANAPC1 ANAPC10 LIN52 DYNC1I2 ANAPC11 DCTN2 SSNA1 CEP164 CCNB2 ACTR1A CCNB1 TUBA1A AKT2 CEP250 AKT3 BTRC CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 SKA1 CEP152 SKA2 HAUS4 CSNK1D HAUS5 TUBG1 HMMR NEDD1 NEK9 CENPJ NEK6 ALMS1 CEP63 AJUBA TUBGCP5 TUBGCP6 AHCTF1 TUBGCP4 NUF2 EMD NUDC FOXM1 RPS27 LBR E2F2 PHLDA1 CENPA NSL1 TUBB2B;TUBB2A TUBAL3 HDAC1 GMNN ORC1 CCNE1 ORC2 GORASP1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI TAOK1 CENPM TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA NUP85 NUP88 SEC13 NUP133 EIF4E NUP205 NUP107 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F12 F2 KLKB1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ-1 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) BDNF PTPN11 FRS2 PIK3R1 CDK5 GAB1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNA1 CCNE1 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PARVB PARVA TESK1 ACTN1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) RPA3 ATR RAD9A POLD4 RFC1 MUS81 EME1-1 EME2 PALB2 SLX1A;SLX1B EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 POLH PCNA WRN RTEL1 BARD1 RBBP8 RPA2 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes AJUBA MED16 MED17 LPIN1 PHLDA1 MGLL CIDEC CDK8 NCOA6 H2BC15;H2BC3;H2BC11;H2BC12 ELOVL5 FABP4 MED23 CDK5 MED24 PLIN2 SCD MED31-1 DGAT2 CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1B INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling IL2 JAK1 CBL IL2RB TEC PTPN11 CSF2 PIK3R1 CSF2RA CRK BLNK SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling AREG EGFR LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CTNNB1 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle PKN2 RACGAP1 PKN1 ERBIN LEMD3 JAG1 KTN1 DOCK1 FAM13B WIPF3 RAB7A FAM13A PIK3R1 SYDE2 PREX2 PREX1 ARHGAP42 BAIAP2L1 OPHN1 CYBB CYBA BCR SPATA13 ARHGAP17 ARHGAP15 IQGAP2 IQGAP3 ARHGAP22 ABL2 NCKAP1L SRGAP2 SRGAP1 MCAM DIAPH3 NOXA1 NOX3 RASGRF2 EMD GIT1 ARHGEF11 PLEKHG1 ARHGEF15 ARAP2 LBR CDC42EP1 WAS SH3BP1 NHS DOCK7 WASF2 WASF3 FARP1 CDC42BPA ABI2 CDC42 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping NOXA1 FZD7 WNT5A CYBA JUN ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO ARRB1 CDON SMO TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis ST3GAL4 MUC1 MUC4 ST6GALNAC3 MUC21 ST6GAL1 ST3GAL1 ST3GAL3 MUC5B DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions POLR2L SNW1 WBP11 PRPF6 PRPF8 H2BC15;H2BC3;H2BC11;H2BC12 CGAS ELAVL2 DYNLT1 BUD31 RPL18 FASN HNRNPA1-1 DHX38 LY96 HNRNPA2B1 RIPK1 SNRPA1 TLR4 CTNNB1 MAPKAP1 HNRNPR PABPN1-1 GRPEL1 SNRPF NRBP1 SDC3 PQBP1 PIK3R4 MLST8 ISY1;ISY1-RAB43 SF3B6 GPC3 XAB2 NUDT21 GPC2 PHF5A MMP9 SNRPE-2 SNRPN GPC4 SNRPG-2 CHERP CTNNBL1 CAMK2B CAMK2D CAMK2A PUF60 CAMK2G PPIL4 POLR2G PDCD6IP APOA1 SRRM2 COG1 GTF2F1 CTR9 SUGP1 PCF11 F2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TAOK1 PPIL1-1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation TRAF2 UBE2V1 TAB2 RIPK2 USP14 NKIRAS1 NKIRAS2 NOD1 IRAK1 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer ICOS RBX1 GZMH;GZMB-1 PRKAR1A BCL2A1 DCTN1 ALK IRS1 FOXM1 FRS2 PIK3R1 PRF1 GCC2 TPM3 MYH9 CCNB1 SEC31A MAPK1 BCL11A MDM2-2 HIP1 NPM1-2 EEF1G RNF213-2 HDAC1 STRN TYK2 JUN DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases MAPK1 PPP2R5D MAPK14 MEF2C JUN RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription TEAD2 TEAD3 TEAD4 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle RHOD RACGAP1 LBR MCAM DIAPH3 ACTN1 LEMD3 EFHD2 ARHGAP17 EMD CPNE8 RAB7A PIK3R1 PLXNA1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling PTK2 DCC ABLIM3 CDC42 DOCK1 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R1 TAS2R4 TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 TAS1R1 TAS1R3 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GNB1 TAS2R39 CALHM1 TAS2R7 TRPM4 TAS2R8 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements ZNF382 HDAC1 ZNF669;ZNF670 MPHOSPH8 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZNF324B;ZNF324 MORC2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation NTHL1 TERF2IP TDG TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RHOA MSI1 GSPT1 CAP2 SLIT1 HOXA2 LHX2 COL4A5 RPL18 ETF1 PSMD8 PSMA6 PSMD12 PSMD11 DCC RPL37A-1 PSMB1 PSMC2-1 RPS15 PSMA7 RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 ABL2 SRGAP2 RPL35 RPL38 SRGAP1 RPL39 SLIT3 RBX1 PRKACB-1 RPL22 PRKAR2A PPP3CB RPL29 LDB1 RPL7A RPS25 RPS27 RPS29 EVL FAU RPS21 RPS24 AKAP5 CDC42 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway DERA G6PD RPE;RPEL1 SHPK TKT TALDO1 PGM2 TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling RIPK1 TRAF2 TAB2 UBE2D3;UBE2D2 TNF TBK1 SPPL2B SPPL2A OTULIN SHARPIN NSMAF MIB2 BIRC2 TNFRSF1A ADAM17 BIRC3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 SSRP1 CTR9 GTF2F1 AFF4 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 MLLT3 TAF5 SUPT6H TAF2 ELL APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 SRGAP2 SRGAP1 CDC42 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora PPP1R3C NHLRC1 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription SNW1 HES5 MAMLD1 FLT4 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions TRAPPC4 SDC3 ITGAV ACTN1 DDR1 SGCD SGCA SGCB SNTA1 LAMA2 DTNA ITGB4 LAMB2 SSPN SNTB1 SNTB2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation ARPC4 PTK2 WAS ACTR3-1 MYH9 NF2 CRK DOCK1 MAPK1 BTK WASF2 MYO10 CD3G WASF3 MYO5A ACTR2 ABI2 WIPF3 CFL1 CDC42 NCKAP1L DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling UBE2V1 PSMD8 CDC34 TAB2 UBE2D3;UBE2D2 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 BTRC CD3G HLA-DPB1-1 RIPK2 HLA-DPA1 PIK3R1 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs MYH10 RHOA MYH9 CFL1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription LAMTOR2 HDAC5 CBX4 GATAD2A BMI1 PHC3 MLST8 MAPK1 HDAC1 EGR1 SNAI1 EZH2 KDM1A RBBP7 JUN NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling MAPK1 FGF19 CBL PTPN11 FRS2 KLB PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRND CHRNB2 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling CETP EEPD1 KDM1B APOE PCK1 APOC2 SCD FASN APOC1 KDM3A KDM1A NRIP1 TNRC6A-1 FABP6 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs MAPK1 MAPK14 FRS2 RIT2 RAP1A CRK MAP2K2;MAP2K1 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE GPCPD1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) RPA3 ATR RAD9A EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 RBBP8 RPA2 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis MAPK1 CTSG RNF213-2 NOS2 VPS33B ATP6V1H ENO1 CORO1A SFPQ-1 RAB7A TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation TBK1 TRAF2 DDX58 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin MAU2 SMC3 STAG2 WAPL MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility LAMA2 PTK2 LAMB2 HGF RAP1A DOCK7 CRK GAB1 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins VKORC1L1 APOA2 APOC3 APOA1 SDC3 APOE APOA4 APOC2 CLPS GPC3 GPC2 APOB GPC4 RETSAT MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle MDH1 MDH2 SLC25A18 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD4 ENTPD8 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle PKN2 RACGAP1 SRGAP1 PKN1 MCAM ERBIN DIAPH3 RHOA ACTC1;ACTG2 KTN1 RASGRF2 C1QBP ARHGEF11 ARHGEF15 ATP6AP1 FAM13A PIK3R1 CCDC115 ARHGEF17 ARAP2 PREX2 LBR PREX1 ARHGAP42 OPHN1 PKN3 TEX2 BCR EMC3 DAAM1 STOM ABCD3 FARP1 IQGAP3 MYO9A ARHGAP22 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known CSNK2B AUTS2 CSNK2A1;CSNK2A3 CBX4 RYBP BMI1 PHC3 PBRM1 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs PKN2 MYH10 PKN1 AR PKN3 H2BC15;H2BC3;H2BC11;H2BC12 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RHOA MYH9 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization CIDEC FITM1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R2 CYB5R1 CA1 CA2 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling FLNA PIK3R1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall TEK L1CAM CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 SDC3 PECAM1 EPCAM PPIL2 MMP1 ATP1B1 SPN SLC16A3 ITGAM SELP CD2 CD244 PTPN11 PIK3R1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SLC7A7 ITGAV SLC7A8 SLC7A11 ATP1B3-1 CD84 PF4;PF4V1-1 APOB JAML CD99 F2 ANGPT4 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival IRAK1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 NQO1 IDH1 TXNRD1 PSMD8 BACH1 RBX1 PSMA6 PSMD12 PSMD11 SLC7A11 TKT TALDO1 PSMB1 PSMC2-1 PSMA7 AREG BTRC G6PD CHD6 ME1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins NUP85 MDM2-2 NUP88 SEC13 SUMO1 NUP133 NUP205 NUP107 PML OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response FLNA RNASEL DDX58 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium PKD2 EXOC7 RAB11A SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection TLR7 PPIH PPIG ST6GALNAC3 SUMO1 ITCH PIK3R4 IFIT3 GANAB ST3GAL4 SMAD4 HNRNPA1-1 ST3GAL1 ST3GAL3 MPP5 RPS25 RPS27 PPIB RPS29 PYCARD CASP1 FAU RPS21 RPS24 RPS15 CHMP2B TBK1 NPM1-2 CHMP3 RPS11 RPS13 CHMP6 ST6GAL1 SFTPD DDX58 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 BTRC PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism ST3GAL4 B3GNT2 ST3GAL6 HEXB ST3GAL1 ST3GAL3 ACAN CHST2 SLC35D2 B4GALT6 GNS ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC22A18 RSC1A1 SLC25A26 SLC47A1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer BDNF EGFR FLT3 HGF KLB GAB1 AREG IRS2 FGF7 KIT FGF22 FGF19 STRN PIK3CG IRS1 PTPN11 FRS2 PIK3R1 PIK3R5 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs RAB5C RAB14 GDI1 RAB1B TRAPPC11 RAB7A DENND2D ANKRD27 DENND4B DENND2B TRAPPC4 TRAPPC10 RAB27A TRAPPC8 TRAPPC6A TRAPPC6B RAB13 RAB38 DENND6B DENND6A RIN2 AKT2 AKT3 AKT1 RAB9A EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation SNAI1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression EPAS1 PTK6 NR3C1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases SLITRK6 LRRC4B PPFIA4 PPFIA3 PPFIA2 SLITRK3 PTPRD SLITRK2 SLITRK5 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition CEP63 AJUBA RBX1 TUBGCP5 TUBGCP6 LCMT1 TUBGCP4 CDK11A;CDK11B MYBL2 FOXM1 PKMYT1 FZR1 PSMD8 PHLDA1 PSMA6 PSMD12 DYNC1I2 PSMD11 LIN52 DCTN2 SSNA1 CEP164 PSMB1 CCNB2 ACTR1A PSMC2-1 PSMA7 CCNB1 PPP2R2A;PPP2R2D TUBA1A CEP250 BTRC CDK5RAP2 CEP78 CCNA1 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D CENPF HAUS5 TUBG1 HMMR NEDD1 CENPJ ALMS1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters MTERF1-1 TFB2M DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass RPA3 USP10 POLD4 RFC1 RBX1 DDB1 RFC5 RFC3 RFC4 RFC2 MAD2L2 REV1 POLH PCNA RCHY1 UBA7 RPA2 UBE2B POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRND CHRNA9 CHRNB2 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions TLR7 MED16 MED17 TLR4 RBX1 SDC3 CDK8 MED28-1 MED8 MED23 MED24 GPC3 GPC2 MED31-1 GPC4 JAK1 CCNC-1 DDX58 TYK2 LY96 SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes CATSPER4 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 DOCK1 JAK1 BIRC2 TYK2 CDC42 CDH11 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling AKT1S1 LAMTOR2 EIF4EBP1 EIF4E EIF4B MLST8 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling TBK1 IL18R1 PTPN20 PTPN7 CASP1 PTPN13 PTPN11 PTPN2 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 BRD2 SNW1 PSMD8 PSMA6 MAMLD1 PSMD12 PSMD11 TEAD2 TEAD3 TEAD4 PSMB1 JAG1 CTNNB1 PSMC2-1 PSMA7 ZFHX3 SMAD4 MDM2-2 TCF7L1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling RAG2 RAG1 PSMD8 PSMA6 PRKACB-1 PSMD12 PSMD11 PSMB1 PSMC2-1 ETV4 PSMA7 MAPK4 TNRC6A-1 JUN CDC42 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CSNK2B CSNK2A1;CSNK2A3 PPP1CC CSNK1D CRY1 CDK5 UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle ASL NMRAL1 NAGS ARG2 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones INHBC PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer MLST8 IRS2 KIT PIK3CG IRS1 FRS2 PTPN11 PIK3R1 BDNF EGFR FLT3 HGF KLB GAB1 MAPKAP1 AREG MDM2-2 AKT2 AKT1S1 AKT3 FGF7 FGF22 FGF19 STRN TSC2 PIK3R5 AKT1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly NPM1-2 MIS18A RSF1 CENPA H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CENPI RUVBL1 CENPM ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE PLAAT3 PLA2G3 LPCAT4 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) BTRC PPP3CB PSMD8 PSMA6 PRKCB REL PSMD12 PSMD11 NFKBIE PSMB1 PSMC2-1 PSMA7 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PTPMT1 PGS1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2D6;LOC107987479;LOC107987478-1 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY TRMT112 MAT2A MTR-1 COMT AS3MT ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation RAP1A CRK EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion GNA14 ACSL3 FFAR1 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein DAD1 ZDHHC9 MGAT4B ST6GALNAC3 RPN2 STT3B RPN1 MGAT4A-1 MAGT1 GANAB ZDHHC3 MGAT5 ST3GAL4 ST6GAL1 ST3GAL1 ST3GAL3 EDEM2 GOLGA7-1 TMEM258 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation HSPA9 TIMM17A-1 IDH2 SPG7 NDUFS3 TWNK OGDH MRPS2 LONP1 NDUFB6 MDH2 UQCRC2 PRELID1 HSD17B10 ARG2 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease POLR2L POLR2G ERLIN2 FGFR3 BCR GTF2F1 GAB1 FGF7 FGF22 ZMYM2 FGFR1OP2 FRS2 PIK3R1 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade PPP2R5D UBE2V1 NOD1 IRAK1 BIRC2 BIRC3 MEF2C PTPN11 MAP3K8 LY96 RIPK1 TRAF2 TLR4 TAB2 UBE2D3;UBE2D2 MAP2K2;MAP2K1 TBK1 MAPK1 BTRC RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 JUN SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer MAPK1 PIK3R1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC TUBA1A TUBB2B;TUBB2A CCT7 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 GNB2 GNB1 GNB4 GNAI2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells AREG GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling EGFR IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) MYD88 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation KLC2 RACGAP1 SEC13 DYNC1I2 DCTN2 KIF18A CTSA CAPZA1 AP1S3 ACTR1A KIF2C LGMN SEC31A CTSH CTSF HLA-DOA DCTN1 DYNC1H1 HLA-DPB1-1 ACTR10 HLA-DPA1 AP2A1 RAB7A AP2A2 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus PIP4K2C FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins ADAR ADARB1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor GNB2 PTGIR GNB1 GNB4 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle SRGAP2 RACGAP1 SRGAP1 DIAPH3 MAP3K11 KTN1 RASGRF2 GIT1 ARHGEF11 CPNE8 PLEKHG1 FAM13B ARHGEF15 WIPF3 RAB7A PIK3R1 ARHGDIG ARAP2 PREX2 LBR PREX1 ARHGAP42 CDC42EP1 OPHN1 WAS FNBP1 BCR DOCK7 DAAM1 STOM SPATA13 ARHGAP17 IQGAP2 FARP1 IQGAP3 CDC42BPA ARHGAP22 CDC42 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants CDC37 ERBIN EGFR CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction SCN8A NPPC STIM1 ORAI2 ATP1B1 AHCYL1 KCNK9 ATP1A1 HIPK1 CAMK2B CAMK2D CAMK2A CAMK2G NKX2-5 KCNIP3 TBX5 ATP1B3-1 KCNK6 ATP2B2 FXYD2;FXYD6-FXYD2 KCNK7 ATP2B1 SLC8A1 SLC8A2 KCNE5 TNNI3 KCNK10 KCNK2 KCNQ1 KCNK4 SCN11A RANGRF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence MAP3K5 TFDP1 TFDP2 E2F3 CBX4 HMGA2 BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 CDK6 EZH2 TNRC6A-1 E2F2 FZR1 UBE2C CDKN2A CDC26 TERF2IP ANAPC1 ANAPC10 TERF2 ANAPC11 MAPK1 ASF1A MDM2-2 H1-3 CDKN2B H1-2 CCNA1 H1-5 CCNE1 MINK1 MAPK14 CXCL8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MAP4K4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDKN2D CDKN2C JUN HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange RPA3 ATR RAD9A PALB2 EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 RBBP8 RPA2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PI4K2B PIK3R4 DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE MTR-1 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins UBAP1 MVB12A TSG101 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDKN2A NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSEN2 APH1A PSENEN NOTCH3 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 SSRP1 GTF2F1 ELL ERCC3 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers NQO1 SNRPF SUMO1 GATAD2A PCK1 H2BC15;H2BC3;H2BC11;H2BC12 G6PC1 SF3B6 FAM124B PHF5A SNRPE-2 IGF2 CHD6 SNRPN SNRPG-2 AXIN2 CHERP PUF60 SNRPA1 PHF10 MYOG SSRP1 CTNNB1 CTR9 PBRM1 MYOD1 BCL11A HDAC1 TCF19 PWWP2B IKZF1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 ZMYND8-1 PWWP2A ADNP H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK PRKAG2 LAMTOR2 STRADA CAB39L PRKAG3 TSC2 MLST8 CAB39 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs PSMD8 PSMA6 PSMD12 PSMD11 ITCH H2BC15;H2BC3;H2BC11;H2BC12 PSMB1 PSMC2-1 PSMA7 MYB LDB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GATA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage ADAL AMPD2 AMPD3 ADA TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI RFC3 RFC4 RPA3 MAD2L2 RFC2 REV1 PCNA RFC1 RPA2 RFC5 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus AKT2 AKT3 AKT1 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling CAMK2A CAMKK2 CAMK2G PDE1A AHCYL1 PRKACB-1 CAMK4 PRKAR1A PRKAR2A CAMK2B CAMK2D LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis SCD FASN NRIP1 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis TSPOAP1 STARD3 STARD3NL AKR1B1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway TLR4 S100A9 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 FGB FGA BTK S100A1 FGG SEC61A2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SEC22B MYD88 LY96 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol NUP85 NUP88 SEC13 NUP133 NUP205 NUP107 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes HSP90B1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling UBE2V1 PLCG2 PSMD8 CDC34 TAB2 UBE2D3;UBE2D2 PSMA6 PSMD12 PSMD11 MS4A2 TEC PSMB1 PSMC2-1 PSMA7 MAPK1 BTK BTRC TXK PPP3CB ITK AHCYL1 PIK3R1 JUN TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade PPP2R5D UBE2V1 NOD1 IRAK1 S100A1 MEF2C MAP3K8 LY96 TRAF2 TLR4 S100A9 TAB2 MAP2K2;MAP2K1 MAPK1 FGB FGA BTK BTRC ECSIT RIPK2 FGG USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism HEXB HYAL3 CSPG5 CHSY3 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic KLC2 RACGAP1 KIF1C SNAP29 KIF21B KIF27 KIF18A KIFC1 M6PR CAPZA1 KIF2C DCTN1 MAN1A1 RAB1B SEC22B BICD1 PAFAH1B2 BICD2 GCC2 USE1 DYNC1I2 VPS52 DCTN2 ARFIP2 TMED7 TMED9 NAA30 COG1 ACTR1A RINT1 NAA38 KDELR2 COG8 RHOBTB3 CYTH4 COG6 DYNC1H1 RAB36 COG2 BET1L ACTR10 KIF12 RAB9A PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease TALDO1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF COL4A5 THBS4 PLG COL4A4 PTPN11 PLAT PIK3R1 THBS2 CRK COL6A3 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle TSPOAP1 RIMS1 PPFIA4 CPLX1 PPFIA3 PPFIA2 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R5E OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling IL34 JAK1 IFNL2;IFNL3;IFNL1 IL10RB IFNLR1 TYK2 CASP3 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation METTL22 KIN FAM86B1;EEF2KMT;FAM86B2 EEF1AKMT2 EEF1AKMT1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 FRAT2 PPP2R5E WNT8A PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis DHRS7B PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling AKT2 PDE3B LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism CETP APOA2 APOC3 APOA1 PRKACB-1 APOE APOA4 APOC2 MTTP APOC1 APOB APOBR AP2A1 AP2A2 MBTPS1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN BDNF RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 GTF2F1 ERCC3 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing MPHOSPH6 RPL18 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 DIS3 RPL31 EXOSC6 CSNK1D EXOSC4 RPL6 EXOSC9 RPL7 EXOSC8 EXOSC2 RPL35 EXOSC1 RPL38 RPL39 RIOK2 GNL3 RPL22 EBNA1BP2 NIP7 ISG20L2 BYSL NOP58 RPL29 RPL7A UTP6 DDX49 UTP11 FCF1 NAT10 WDR75 RPS25 NOC4L RPS27 IMP4 DDX52 RPS29 RRP9 RCL1 RRP7A PDCD11 FAU DKC1 BMS1 RPS21 DCAF13 RPS24 UTP14C;UTP14A RPP40 NOP10 RPP21 RPP14 TRMT10C PRORP TRMT112 NGRN XRN2 HSD17B10 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system C1QBP F12 PRCP H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KLKB1 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F10 F2 F9 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism VDR LGMN AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy UBE2V1 DYNC1H1 DYNC1I2 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections PPIH HMG20B PPIG GATAD2A BLNK HNRNPA1-1 RIPK1 NPM1-2 AKT1 RBX1 ITCH SMAD4 NUP205 NUP107 NUP85 PLCG2 NUP88 SEC13 NUP133 CHMP2B CHMP3 BRMS1 CHMP6 DDX58 AP2A1 AP2A2 FKBP4 SUMO1 NR3C1 IFIT3 COMT ATP1B1 ATP1A1 PPIB ATP1B3-1 MGAT4A-1 FXYD2;FXYD6-FXYD2 GEMIN2 MAGT1 ZDHHC3 RPS15 TBK1 AKT2 BTK AKT3 RPS11 RPS13 JAK1 CYSLTR1 ST6GAL1 RIPK2 VPS33A VPS33B SFTPD ANO6 GOLGA7-1 TYK2 TUFM TMEM258 DAD1 TLR7 UBE2V1 SNRPF MASP1 ST6GALNAC3 ISCU RPN2 SDC3 RPN1 PIK3R4 DDX20 NOD1 GANAB IRAK1 MGAT5 ST3GAL4 BRD4 PTGES3-1 GPC3 VPS11 GPC2 SNRPE-2 GPC4 SNRPG-2 ST3GAL1 ST3GAL3 VPS16 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 PTPN11 MPP5 SRPK1 SIGMAR1 RPS25 RPS27 ZDHHC9 RPS29 PYCARD MGAT4B IL17F TAB2 CASP1 FAU STT3B RPS21 RPS24 IL17A IL1R1 SAP30 SH3KBP1 HDAC1 SAP30L KDM1A RBBP7 PHF21A SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors NPM1-2 PIAS3 PCGF2 SUMO1 CBX4 BMI1 ING2 PHC3 NRIP1 CTBP1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions PTK2 SIRPB1 PTPN11 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay EXOSC2 CNOT9 EXOSC1 LSM2 PABPC1;PABPC3 DIS3 EXOSC6 EIF4E EXOSC4 EIF4B CNOT6 EXOSC9 CNOT7 EXOSC8 DCP2-1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2R5D PFKFB1 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins ZMYM2 PIK3R1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression POLR2L HDAC1 TAF1D GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MYBBP1A GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNB2 KCNJ3 KCNJ5 GABBR2 KCNJ10 GNB1 GNB4 KCNJ15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock RBX1 CDK5 TGS1 MEF2C CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 CPT1A PSMD12 PPP1CC PSMD11 NCOA6 CRTC1 PSMB1 CRY1 TFEB PSMC2-1 PSMA7 BTRC ARNTL2 CSNK1D NRIP1 CRTC3 RAI1 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis AKR1B1 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 CYP11B1;CYP11B2 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors GNB2 KCNJ3 KCNJ5 GABBR2 KCNJ10 GNB1 GNB4 KCNJ15 GNAI2 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation PDE1A REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPAS1 ARNT HIGD1A C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen FGB FGA FGG PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation PIP4K2C ING2 PIN1 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways TXNRD1 UBE2D3;UBE2D2 PDCD6IP SYT2 CBL SFPQ-1 GBP2;GBP3;GBP1 CTNNB1 MAP2K2;MAP2K1 EPCAM MAPK1 CTSG STAM2 RNF213-2 SH3KBP1 SV2A EPS15 CD9 NOS2 VPS33B ENO1 ATP6V1H CORO1A RAB7A DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN PSMD8 PSMA6 PSMD12 PSMD11 AXIN2 PSMB1 RNF146 PSMC2-1 PSMA7 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD GPC3 GPC2 GPC4 SDC3 CSPG5 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance POLR2L STN1 DSCC1 POLD4 RFC1 H2BC15;H2BC3;H2BC11;H2BC12 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA WRN RPA2 RPA3 POLR2G ATRX DKC1 TERF2IP TERF2 RUVBL2 NOP10 RUVBL1 CCNA1 ANKRD28 RTEL1 PPP6C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PIF1 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling AKT2 AKT3 CSK PTPRJ SH2B3 CBL FLT3 PTPN11 PIK3R1 AKT1 ABL2 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHB DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones HSP90B1 MBTPS1 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia AJUBA PSMD8 UBE2D3;UBE2D2 RBX1 PSMA6 EPAS1 PSMD12 ARNT PSMD11 PSMB1 PSMC2-1 PSMA7 HIF3A LIMD1 HIGD1A DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 DHDDS RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control RPL35 RPL38 RPL39 RBX1 RPL22 RPL18 RPL29 RPL7A RPS25 RPS27 TCF25 RPS29 PSMD8 UBE2D3;UBE2D2 PSMA6 FAU PSMD12 RPS21 PSMD11 RPS24 PSMB1 RPL37A-1 ASCC2 PSMC2-1 PSMA7 RPS15 RPS11 RPS13 RPL4 RCHY1 RPL30 RPL31 RPL6 RPL7 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function CDH24 CDH8 CTNNB1 CDH11 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling PPP2R5A SUMO1 IFIT3 GBP2;GBP3;GBP1 EIF3C;EIF3CL EIF3L EIF2S2 EIF3E HLA-DPB1-1 EIF2S3;EIF2S3B EIF3B HLA-DPA1 ADAR RPS15 MAPK1 TRIM8 NPM1-2 RPS11 RPS13 EGR1 JAK1 RNASEL EIF4E FANCC TYK2 ILF2 PIN1 KPNA4-1 TRIM62 IP6K2 TRIM38 TRIM31 PTPN2 IFI35 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EIF4G3 IRF5 NUP205 PTPN11 NUP107 CAMK2B CAMK2D PML RPS25 CAMK2A RPS27 NUP85 RPS29 CAMK2G NUP88 CASP1 SEC13 ISG20 FAU NUP133 IRF6 RPS21 RPS24 TRIM21 IRF9 GBP7;GBP4 MT2A LOC105377022;FANCB FLNA SPHK1 UBA7 DDX58 ILF3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation RPS27 RPL35 RPS29 RPL38 RPL39 FAU RPS21 RPS24 RPL22 RPL37A-1 RPS15 RPL18 RPS11 RPS13 RPL4 RPL30 RPL29 RPL31 RPL7A RPL6 RPL7 RPS25 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal ASCC1 MGMT ASCC2 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RPS27 PPIB TLR7 RPS29 PYCARD PPIH PPIG CASP1 FAU RPS21 ITCH RPS24 IFIT3 RPS15 TBK1 SMAD4 NPM1-2 HNRNPA1-1 RPS11 RPS13 SFTPD DDX58 MPP5 RPS25 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog IFT140 IFT122 ARRB1 FUZ KIF7 RBX1 PRKACB-1 IFT52 ITCH SMO PRKAR1A PRKAR2A HHAT ADAM17 PSMD8 PSMA6 PSMD12 PSMD11 CDON SYVN1 PSMB1 PSMC2-1 PSMA7 BTRC DZIP1 CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects PDE11A PDE10A PDE1A KCNMB1 KCNMB4 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection CTSG GSDMD C3AR1 P2RX4 PYCARD P2RX7 CASP1 SUGT1 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSMD8 PSMA6 PSMD12 PSMD11 PSMD10 PSMB1 PSMD9 POMP PSMC2-1 PSMA7 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors APOB MSR1 MASP1 S100A9 SCARA5 SCGB3A2 APOA1 HSP90B1 APOE FTH1 CD5L HP;HPR LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase TFDP1 TFDP2 POLD4 RFC1 RBX1 PTK6 WAPL RFC5 RFC3 POLA2 RFC4 RFC2 PCNA RPA2 RPA3 FZR1 PSMD8 UBE2C PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 LIN52 GINS1 ANAPC11 GINS2 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 AKT2 AKT3 GMNN CCNA1 ORC1 ORC2 CCNE1 SMC3 STAG2 AKT1 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling BTRC PRLR RBX1 PTPN11 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling MAPKAP1 AKT2 AKT3 TRIB3 MAP3K14 PIK3CG MLST8 MAP3K8 PIK3R1 AKT1 PIK3R5 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events LIN52 CENPF MYBL2 FOXM1 CCNB2 CCNB1 PKMYT1 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism AMDHD1 UROC1 CARNS1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases USP37 WDR20 USP24 POLB USP25 ARRB1 USP20 AR USP44 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 USP28 PTRH2 H2BC15;H2BC3;H2BC11;H2BC12 SMAD4 BIRC2 BIRC3 AXIN2 RIPK1 USP10 TRAF2 USP15 PSMD8 PSMA6 TRRAP PSMD12 PSMD11 RUVBL1 PSMB1 TGFBR1-1 USP7 PSMC2-1 RNF146 OTUB1 PSMA7 RCE1 MDM2-2 VDAC1 STAM2 IL33 CCNA1 CLSPN USP9X USP14 VDAC3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 DDX58 USP22 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS MUC1 MUC4 MUC21 MUC5B PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events AKT2 PDE3B ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCD3 ABCA2 APOA1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation DAGLA DGKB LGALS3BP PECAM1 WDR1 RHOA OLA1 LEFTY2;LEFTY1 SYTL4 NHLRC2 CRK ENDOD1 PRKCH CLEC3B DGKZ APOH MANF DGKK CALU IGF2 CD9 TRPC6 P2RY1 PIK3R1 CFL1 PRKCB MGLL F2RL2 ACTN1 RAP1A MAPK1 MAPK14 MPIG6B PDPN LAMP2 AKT1 PIK3R5 ARRB1 PSAP PTK2 PLG IGF1 APBB1IP CYB5R1 PIK3CG SELP ORM2;ORM1 CFD PTPN11 CD63 PLCG2 APOA1 ADRA2A HGF TGFB2 FGB FGA FLNA CSK GNA14 FGG GNB2 F2 TTN-1 GNB1 GNB4 GNAI2 CDC42 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) FZR1 UBE2C CDKN2A CDC26 ANAPC1 ANAPC10 ANAPC11 H2BC15;H2BC3;H2BC11;H2BC12 MAPK1 CDKN2B CCNA1 CDK6 CXCL8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CDKN2D H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDKN2C JUN PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders HDAC1 CAMK4 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines TBK1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins HGF SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer CDC37 EGFR CBL PIK3R1 GAB1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane PI4K2B PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling LOC105377022;FANCB PPP2R5A NPM1-2 SPHK1 ADAR SUMO1 EIF2S2 EIF2S3;EIF2S3B FANCC ILF3 PTPN2 ILF2 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function ZC3H12A CTNNB1 CDH19 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling S1PR3 PTK2 EGFR AREG MAPK1 MMP7 AKT2 AKT3 SPHK1 CAV2 MMP9 GNB2 STRN GNB1 GNB4 PIK3R1 GNAI2 AKT1 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL TDGF1 NODAL ACVR1B DAND5 CER1 LEFTY2;LEFTY1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG MTR-1 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing POLR2L SNRPF PRPF40A SNRPC SF3B6 SRSF10 NUDT21 PHF5A HNRNPA1-1 SNRPE-2 SNRPN DDX39B SNRPG-2 THOC1 DHX38 THOC3 THOC6 CHERP HNRNPA2B1 PUF60 SNRPA1 POLR2G SRRM2 GTF2F1 SUGP1 RBBP6 PCF11 HNRNPR XRN2 PABPN1-1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport EMB SLC16A3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL PPP2R5B PPP2R5A PPP2R5D PPP2R5C APOB MAPK14 PECAM1 PTPN11 PPP2R5E MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing POLR2L SNW1 WBP11 PRPF6 PPIH PPIG PRPF8 BUD31 HNRNPA1-1 DDX39B DHX38 HNRNPA2B1 SNRPA1 HNRNPR NSRP1-1 PPWD1 PNN RBMX2 SNRNP35 SNRPF PRPF4B PRPF40A CXorf56-1 PRPF18 PRPF3 PQBP1 C9orf78 SNRNP27 SNRNP25 SNRPC ISY1;ISY1-RAB43 CACTIN SF3B6 CWF19L2 DHX35 SRSF10 XAB2 PRPF38A PPIL2 PHF5A SNRPE-2 CCDC12 SNRPN LSM2 SNRPG-2 LSM8 CHERP CTNNBL1 PUF60 PPIL4 POLR2G SRRM2 GTF2F1 SUGP1 PPIL1-1 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) SGCA SGCB SNTA1 LAMA2 DTNA LAMB2 SSPN SNTB1 SGCD SNTB2 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells LAMA2 LAMB2 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants FLT3 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway POLB DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate PDXK AOX1 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 FGF7 FGF22 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade PPP2R5D TRAF2 UBE2V1 TAB2 NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MEF2C MYD88 MAP3K8 JUN PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling PIK3R1 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) BARD1 DCLRE1C PRKDC HERC2 XRCC4 TDP2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLL NHEJ1 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR2L SNAPC1 SNAPC2 POLR3A POLR3D POLR3F POLR3K BRF2 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHB COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism MMAB MTR-1 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins NUP85 XPC NUP88 SEC13 CBX4 SUMO1 NUP133 XRCC4 BMI1 HERC2 PHC3 SMC6 NSMCE1 PCGF2 WRN NSMCE4A TDG SMC3 STAG2 NUP205 NUP107 PML INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease SNW1 HMG20B CBL SFPQ-1 CRK DOCK1 FASN HNRNPA1-1 EPS15 MYO10 MYO5A DHX38 NOS2 ATP6V1H CORO1A RAB7A HNRNPA2B1 LY96 GSDMD RIPK1 SNRPA1 TLR4 UBE2D3;UBE2D2 MYH9 MAP2K2;MAP2K1 MAPKAP1 MAPK1 C3AR1 NPM1-2 P2RX4 RPL4 RPL30 RPL31 PABPN1-1 ENO1 EIF4E RPL6 RPL7 RPL35 RPL38 RPL39 RPL22 MLST8 MED8 RPL29 PML PLCG2 BRMS1 FKBP4 SUMO1 NR3C1 MED28-1 RPL18 WIPF3 PPIB CSNK2B CSNK2A1;CSNK2A3 EGFR PPP1CC DYNC1I2 CYBA RPL37A-1 BTK BTRC STAM2 DYNC1H1 HNRNPR CLDN1 TYRO3 NCKAP1L GRPEL1 KPNA4-1 ARPC4 PTK2 NOXA1 PQBP1 ACTR3-1 ISY1;ISY1-RAB43 SF3B6 EPCAM CTSG BRD4 XAB2 NUDT21 PHF5A MMP9 SNRPN ADAM17 LY6E BAG2 ACTR2 CHERP EIF4G3 RPL7A CTNNBL1 SIGMAR1 PSIP1 PUF60 MED16 MED17 DNAJA2 PPIL4 WAS APOA1 SRRM2 IL1R1 COG1 SAP30 CTR9 MED23 MED24 SUGP1 GTF2H2C;GTF2H2C_2;GTF2H2 SH3KBP1 HDAC1 WASF2 WASF3 CCNC-1 PCF11 CHMP1A SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ABI2 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPRE3 TAOK1 PPIL1-1 POLR2L WBP11 PRPF6 PPIH GTF2H3 PPIG TXNRD1 RTN3 PRPF8 GATAD2A SYT2 CDK8 H2BC15;H2BC3;H2BC11;H2BC12 CGAS ELAVL2 GBP2;GBP3;GBP1 BLNK ERCC3 DYNLT1 BUD31 MED31-1 SV2A AHCYL1 EZH2 CD9 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 PABPC1;PABPC3 MAPK14 AKT1 RBX1 PRKACB-1 NRBP1 ITCH PRKAR1A PRKAR2A SMAD4 NUP205 NUP107 TSG101 CAMK2B ELL CAMK2D TAF7L CAMK2A NUP85 MVB12A RCC1 CAMK2G NUP88 POLR2G SEC13 PDCD6IP NUP133 XRCC4 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CHMP2B NMT1 UBAP1 CHMP3 TAF7 TAF5 CHMP6 TAF2 F2 UBA7 DDX58 AP2A1 AP2A2 GNAI2 IFIT3 VPS25 COMT GGT1 ATP1B1 DPEP1 ATP1A1 PIK3R1 ATP1B3-1 FXYD2;FXYD6-FXYD2 MGAT4A-1 GEMIN2 MAGT1 ZDHHC3 RPS15 TBK1 AKT2 AKT3 RPS11 RPS13 GNAZ CD3G JAK1 ST6GAL1 CYSLTR1 RIPK2 VPS33A VPS33B SFTPD ANO6 GOLGA7-1 TYK2 TUFM TMEM258 DAD1 TLR7 RAB5C UBE2V1 SNRPF MASP1 ST6GALNAC3 ISCU RPN2 SDC3 RPN1 PIK3R4 DDX20 AP1S3 NOD1 GANAB IRAK1 MGAT5 ST3GAL4 GPC3 PTGES3-1 VPS11 GPC2 SNRPE-2 GPC4 SNRPG-2 ST3GAL1 ST3GAL3 VPS16 FZD7 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 WNT5A PTPN11 MPP5 SRPK1 RPS25 RPS27 ZDHHC9 RPS29 PYCARD MGAT4B IL17F P2RX7 TAB2 FAU CASP1 STT3B SUGT1 RPS21 RPS24 IL17A RNF213-2 UBA6 GNB2 KDM1A GNB1 GNB4 PHF21A JUN CDC42 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses TBK1 PPIB TLR7 PYCARD PPIH PPIG CASP1 ITCH SFTPD DDX58 IFIT3 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA NUP85 NUP88 SEC13 NUP133 EIF4E NUP205 NUP107 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate SLC35D2 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions TSG101 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 GPC3 GPC2 GPC4 SDC3 CSPG5 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT MAOA COMT LRTOMT TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1-1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy MFN1 UBE2V1 MFN2 EPAS1 PRKAG3 PIK3R4 MLST8 GABARAP ATG101 TSG101 ATG3 GABARAPL2 ATG13 ATG4A CSNK2B ATG4D MVB12A LAMTOR2 CSNK2A1;CSNK2A3 UBE2D3;UBE2D2 DYNC1I2 CHMP2B TBK1 PRKAG2 UBAP1 PLIN2 CHMP3 VDAC1 DYNC1H1 CHMP6 TSC2 VDAC3 TOMM7 ATG5 LAMP2 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins PRSS3;PRSS2;PRSS1 DEFB129 DEFB127 ART1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SNRPF SNRPE-2 SNRPG-2 ZNF473 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import COA4 HSPA9 TIMM21 GRPEL1 CHCHD10-1 TIMM17A-1 TIMM17B PMPCB BCS1L MTX2 VDAC1 NDUFB8 TOMM7 ATP5MC1 HSCB VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport KLC2 ANK2 RACGAP1 KIF1C SPTBN4 KIF21B SYT2 SPTB KIF27 CBL KIF18A KIFC1 RAB14 CAPZA1 KIF2C GOLGA2 DCTN1 EPS15 MYO5A SEC22B RAB7A S100A9 MYH9 COG8 APOB CYTH4 COG6 MSR1 SCARA5 RAB36 COG2 SCGB3A2 HSP90B1 BET1L ACTR10 GJC2 GJB4 GJA9 AKT1 GJA8 SYT9 SLC18A3 UBQLN2 AP1G2 PRKAG3 APOE ANK1 MAN1A1 GDI1 RAB1B GABARAP GGA3 TBC1D13 TRAPPC11 EXOC7 TBC1D10B GNS TSG101 DENND2D GABARAPL2 RAB11A ANKRD27 DENND4B BICD1 INS;INS-IGF2 DENND2B PAFAH1B2 MVB12A TRAPPC4 BICD2 TRAPPC10 RAB27A TRAPPC8 SEC13 RAB11B USE1 TRAPPC6A TRAPPC6B VPS52 ARFIP2 RAB13 TBC1D24 TMED7 RAB38 TMED9 DENND6B NAA30 RINT1 PREB DENND6A RIN2 CHMP2B NAA38 KDELR2 PRKAG2 UBAP1 CHMP3 CHMP6 AP2A1 AP2A2 CD5L COPS7B COPS7A COPS8 VPS25 PICALM AMPH C2CD5 FNBP1 MIA2 TBC1D4 EGFR DYNC1I2 DCTN2 SLC2A4 ACTR1A HP;HPR AKT2 AKT3 STAM2 RHOBTB3 CD3G DYNC1H1 CSNK1D MYO6 TBC1D8B RAB5C SORT1 HIP1R MASP1 ARRB1 ARPC4 SNAP29 AP3B1 TPD52L1 BLOC1S4 BLOC1S1 DNAJC6 FTH1 BLOC1S3 ACTR3-1 AP1S3 M6PR SYNJ1 SPTAN1 ACTR2 FZD4 WNT5A GCC2 IL7R APOA1 COG1 SEC31A AREG HIP1 SH3KBP1 ANKRD28 PPP6C SEC23IP GORASP1 TSC2 LMAN2 SEC22C KIF12 RAB9A TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression SMAD4 RARA MYOG TNRC6A-1 MYOD1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism TXNRD1 ENTPD4 ENTPD8 AMPD2 GDA AMPD3 NME1 ADA NME6 PAICS NME4-1 ADAL AK4-1 TYMS XDH RRM1 AK6 PPAT DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling BTRC PSMD8 PSMA6 PSMD12 MAP3K14 PSMD11 PSMB1 PSMC2-1 PSMA7 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres STN1 DSCC1 RPA3 POLD4 RFC1 DKC1 TERF2IP TERF2 RUVBL2 NOP10 RUVBL1 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA CCNA1 ANKRD28 WRN RTEL1 PPP6C PIF1 RPA2 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane DAD1 MIB2 JAK1 RPN2 PDCD1LG2 STT3B RPN1 MAGT1 TMEM258 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC8B1 SLC8A1 SLC8A2 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis STN1 DSCC1 RPA3 POLD4 RFC1 TERF2IP TERF2 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA WRN RPA2 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH RFC3 RFC4 RPA3 RFC2 POLH PCNA RFC1 RCHY1 RPA2 RFC5 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion UBAP1 MVB12A TSG101 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface MASP1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling ATP5MC1 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade TLR7 PPP2R5D UBE2V1 NOD1 IRAK1 TASL IRF5 MEF2C MAP3K8 LY96 TRAF2 TLR4 TAB2 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing CTSG GSDMD CASP1 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions TRAPPC4 SDC3 ITGAV ITGB4 ACTN1 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane CEP63 B9D2 TCTN3 SCLT1 KIF24 RAB11A AHI1 DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF PTK2 FLT4 PRKACB-1 RHOA MLST8 CRK DOCK1 AHCYL1 PIK3R1 PRKCB KDR ITGAV CYBB CYBA CTNNB1 MAPKAP1 AKT2 AKT3 SPHK1 TRIB3 WASF2 WASF3 MAPK14 ABI2 AKT1 CDC42 NCKAP1L INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters SLC4A3 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS PTDSS2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation MAPK1 PLCG2 JUN SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins NUP85 NUP88 SEC13 SUMO1 NUP133 NUP205 NUP107 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling MAPK1 FGF7 FGF22 CBL PTPN11 FRS2 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins PLEC MAPT SPTAN1 CASP3 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases SLC37A4 PPP1R3C NHLRC1 GAA G6PC1 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production GNAZ PRKACB-1 GNB2 GNB1 PRKAR1A PRKAR2A GNB4 GNAI2 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse MYH10 RHOA MYH9 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases CASP1 PIDD1 CRADD CASP2 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT7 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex BCL11A PHF10 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling SNW1 MAMLD1 JAG1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling ATP6V0A4 ATP6V1F ATP6V0D2 ATP6V1A ATP6V1H ATP6AP1 TCIRG1 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation LRRC7 CAMK2A NRGN CAMK2G CAMK2B CAMK2D MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 GFPT1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events GPC3 CHMP3 GPC2 GPC4 CHMP6 ISCU SDC3 PIK3R4 CHMP2B METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors CYB5A GCH1 MMAB APOC3 APOC2 FOLR2 PANK4 PPCS FASN ENPP2 SLC23A2 SLC46A1 NMNAT2 SLC23A1 MTR-1 PDZD11 COQ8A VKORC1L1 IDH1 ALDH1L1 COQ6 SLC52A1;SLC52A2 NUDT12 SLC5A6 SLC25A51;SLC25A52 BTD APOB PC ACACB AOX1 AKT1 LMBRD1 SDC3 APOE CLPS ACO1 MTHFD1 PDXK GPC3 GPC2 GPC4 PRSS3;PRSS2;PRSS1 PDSS2 CD320 SPR RETSAT SLC22A13 SLC19A3 APOA2 SLC19A1 APOA1 TCN2 APOA4 TCN1 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway UBE2V1 TAB2 CASP1 BIRC2 RIPK2 CARD9 MAPK14 BIRC3 ITCH NOD1 CASP2 IRAK1 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB AKT2 TRIB3 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines NQO1 AMD1 PSMD8 PSMA6 PSMD12 PSMD11 AGMAT PSMB1 SRM PSMC2-1 PSMA7 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption SLC5A1-1 LIPF PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUCA2A RSC1A1 CLPS G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase CCNA1 E2F3 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins HSD17B4 PHYH-4 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly CEP63 TFDP1 IFT140 B9D2 IFT122 DEUP1 IFT52 MCIDAS SMO GMNC CCNO ARL6 PKD2 MCHR1 TCTN3 BBS7 EXOC7 SCLT1 TTC26 TNRC6A-1 KIF24 RAB11A IFT43 AHI1 IFT81 DYNLT2B DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 GMNN CEP78 DYNC1H1 CEP135 MYB ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events RDH12 OPN1SW CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin TUBA1A VASH2 TUBB2B;TUBB2A VASH1 AGBL5 TTLL6 TTLL5 AGTPBP1 AGBL1 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease ZMYM2 ERLIN2 FGFR1OP2 FRS2 BCR PIK3R1 GAB1 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis HSD11B1 CYP11B1;CYP11B2 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B F10 F11 F9 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 FGF22 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking NOSIP REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition STT3B EDIL3 PXDN CDH2 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RHBG MRS2 AZGP1 NIPAL1 NIPA1 MAGT1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs ELOVL6 ACSL3 HACD1 ELOVL5 ELOVL1 TECR TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs RAB5C RAB11B TSC2 GABARAP GGA3 TBC1D13 TBC1D24 RAB7A TBC1D10B GABARAPL2 RAB11A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding FGF19 KLB NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus JAG2 MIB2 PSEN2 APH1A EGFR PSENEN JAG1 NOTCH3 MIB1 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism CRAT HACL1 HSD17B4 DECR2 AMACR SLC25A17 PHYH-4 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation OGDH COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly COX7C COX20 SCO2 TIMM21 COX6C HIGD2A COA3 HIGD1A RAB5IF COX6A1 SCO1 COX6A2 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression EXOSC2 EXOSC1 EIF2S2 DIS3 EIF2S3;EIF2S3B EXOSC6 CXCL8 EXOSC4 EXOSC9 EXOSC8 DCP2-1 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 CDC37 ERBIN SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins NUP85 NOP58 NUP88 PCGF2 SEC13 SUMO1 CBX4 NUP133 BMI1 PHC3 NUP205 NUP107 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs POLR2L POLR2G H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TNRC6A-1 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism PIPOX ALDH7A1 CRYM SLC25A21 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex TAB2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation H1-3 H1-2 H1-5 CASP3 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction RPA3 ATR CATSPER4 TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 NANOG;NANOGP8 ZP3;POMZP3 CD9 CBFA2T2 POU5F1;POU5F1B RBBP8 SMC3 PDPN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SUN1 STAG2 RPA2 MLH3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 REC8 SMC1B STAG3 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling CRMP1 DPYSL5 DPYSL2 DPYSL3 PLXNA2 PLXNA1 CDK5 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine GLYATL3 ACSM5 ACSM4 GLYAT ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 DGAT2 MGLL DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 PPP2R5E 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding GNB2 GNB1 GNB4 GRIK5 GRIK4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling ITCH DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction RDH12 OPN1SW MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins OPN3 OPN1SW OPN4 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNB1 BTRC CCNA1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome TLR7 PPP2R5D TRAF2 UBE2V1 TLR4 TAB2 NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MEF2C MYD88 MAP3K8 JUN LY96 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib CDC37 ERBIN ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex TAB2 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity C1QBP F12 KLKB1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors AKT2 AKT3 BANP AKT1 POU4F1 ZNF385A PHF20 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK RASGRF2 PREX1 ARHGEF11 ARHGEF15 ARHGEF17 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking GJC2 MYO6 GJB4 GJA9 GJA8 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER RPA3 POLD4 RFC1 GTF2H3 PARP2 RBX1 DDB1 RFC5 ERCC3 RFC3 RFC4 GTF2H2C;GTF2H2C_2;GTF2H2 RFC2 PCNA RPA2 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C H2BC15;H2BC3;H2BC11;H2BC12 KIF18A KIF2C PKMYT1 PSMD8 UBE2C PSMA6 CDC26 PPP1CC ANAPC1 PSMD12 DYNC1I2 PSMD11 ANAPC10 ANAPC11 CDC45 MCM8 PSMB1 CCNB2 PSMC2-1 RHNO1 PSMA7 CCNB1 MDM2-2 BTRC PCBP4 CCNA1 DYNC1H1 BARD1 SKA1 MAPK14 SKA2 ATR RAD9A RBX1 EXO1 ZNF385A AHCTF1 RFC5 RFC3 RFC4 NUF2 RFC2 WRN RBBP8 NUDC RPA2 NUP107 COP1 PHF20 RPS27 NUP85 RPA3 SEC13 NUP133 HERC2 CENPA NSL1 ORC1 CLSPN CCNE1 ORC2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF CENPI TAOK1 CENPM PPP2R5E DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription POLR2L GTF2H3 UBTF GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 TAF1D RRN3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors ADRA2A FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer RBX1 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway CAMK2A CAMKK2 CAMK2G PDE1A PRKACB-1 CAMK4 PRKAR1A PRKAR2A CAMK2B CAMK2D PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion VPS33B CORO1A RAB7A COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic KLC2 RACGAP1 KIF1C KIF21B USE1 KIF27 KIF18A KIFC1 TMED7 TMED9 RINT1 KIF2C KDELR2 RAB1B KIF12 SEC22B DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology SNW1 TFDP1 TFDP2 MAMLD1 EPAS1 RHOA DOK1 ZFPM2 DOCK1 MYO10 MYO5A KLK5 KLK14 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 ATP6V1H TRPC6 LIPJ LIPN RDX PKP1 CFL1 SPINK9 LIPK IVL IL12RB2 GCK HOXA3 DCC UNC5C HOXB3 MYH9 HOXB2 HOXB1 MAP2K2;MAP2K1 MAPK1 DICER1 RPL4 ZFP36L2 DPPA4 RPL30 TPRX1;RAX2 RPL31 PABPN1-1 DUX4;DUXA EIF4E EIF4B RPL6 CNOT6 RPL7 CNOT7 RPL35 TDGF1 CNOT9 RPL38 RPL39 SLIT3 PMEL EDIL3 RPL22 MED8 CNTN6 ANK1 PDX1 MAFA NEUROD1 PTF1A FOXA2 NKX2-2 PERP RPL29 KDM5B PSEN2 ACVR1B APH1A ITGAV AMH CER1 PSENEN MYOG MYOD1 HIF3A CACNA1H SUMO1 DSP RARA ASAH1 MED28-1 MSI1 LEFTY2;LEFTY1 GSPT1 SLIT1 HOXA2 LHX2 RPL18 COL4A5 PKP4 ETF1 KIT NODAL DAND5 PLXND1 COL4A4 PXDN COL6A3 CSNK2B CSNK2A1;CSNK2A3 EGFR RPL37A-1 NANOG;NANOGP8 CCNB1 SNAI1 GFI1 KRT16;KRT14 KRT4 KRT2 KRT8 KRT9 PLXNA1 KRTAP16-1 ABL2 GDF1 FLI1 SRGAP2 KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 AJUBA MYH10 KRT20 SRGAP1 KRT18 KRT15 KRT74 ARPC4 PTK2 ADGRG6 MBP ZNF423 KRT3;KRT76 KRT85 ACTR3-1 PMP22 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 SPTAN1 MMP9 GIT1 ARHGEF11 TBX1 MESP1 ACTR2 RPL7A MED16 MED17 EVL MEN1 NCOA6 MED23 MED24 PRNP CACNA1I SH3KBP1 HDAC1 CCNC-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 SCN11A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EPHB1 EPHB4 EPHB3 PPARGC1B EPHA5 IARS1 POLR2L ANK2 SHTN1 DOK6 SCN8A HDAC5 SPTBN4 KLF13 L1CAM CBX4 RGMB SATB1 IL13 GATAD2A SPTB BMI1 RGMA CDK8 PHC3 DSCAML1 H2BC15;H2BC3;H2BC11;H2BC12 RELN FABP4 TNF BATF ABLIM3 CAP2 YY1 MAF CDK5 CCL3L1;CCL3L3;CCL3;CCL18 BCL2A1 MED31-1 EZH2 LAMA2 LAMB2 MEF2C PTGDS PSMD8 NKX2-5 PSMA6 EPHA4 PSMD12 TEAD2 PSMD11 RIPPLY2 TEAD4 MSGN1 PSMB1 CTNNB1 PSMC2-1 PSMA7 DLL3 PCGF2 PABPC1;PABPC3 MAPK14 AKT1 RBX1 PRKACB-1 PCK1 PRKAR2A SMAD4 AIMP1 LDB1 INS;INS-IGF2 RAB27A POLR2G TBX5 TFEB ALX3 MITF AKAP5 SEMA5A AP2A1 AP2A2 RANBP9 JAG1 EYA1 HOXD11 WNT10B HOXA11 GDNF PAX8 HNF4A SIX2 LHX1 HOXB4 ID4 HOXA6 ATP6V1A FRS2 PIK3R1 TNRC6A-1 CDKN2A CDON SLC2A4 KLF5 RPS15 AKT2 AKT3 RPS11 RPS13 DCT THRAP3 IRS2 PPP3CB SEMA7A CRMP1 TGS1 DPYSL5 DPYSL2 DPYSL3 PLXNA2 PTPN11 PLXNB3 SRPK1 CDH4 RPS25 CDH2 RPS27 CDH15 CTNNA2 RPS29 NTN3 LGI2 ADAM23 ADAM11 CACNG3 FAU STT3B RPS21 RPS24 GAB1 AREG FGF7 TCF7L1 ZIC1 MYB POU5F1;POU5F1B JUN CDC42 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease KIT PIK3R1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis MED16 MED17 THRAP3 GATAD2A ZNF423 CDK8 PCK1 NCOA6 SLC2A4 TNF FABP4 MED28-1 KLF5 MED8 MED23 MED24 WNT10B SMAD4 HDAC1 MED31-1 CCNC-1 TGS1 RBBP7 PPARGC1B GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport KLC2 RACGAP1 KIF1C KIF21B KIF27 KIF18A KIFC1 CAPZA1 KIF2C DCTN1 RAB1B SEC22B BICD1 PAFAH1B2 BICD2 USE1 DYNC1I2 DCTN2 TMED7 TMED9 ACTR1A RINT1 KDELR2 DYNC1H1 ACTR10 KIF12 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis PPP2R5B PPP2R5A PPP2R5D PPP2R5C PECAM1 STIM1 ORAI2 PTGIR NOS2 TRPC6 PTPN11 PDE11A PDE10A PDE1A P2RX7 KCNMB1 KCNMB4 ATP2B2 ATP2B1 SLC8A1 SLC8A2 P2RX4 APOB GNB2 MAPK14 GNB1 GNB4 PPP2R5E DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion GNA14 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression RAB27A CDKN2A DCT STT3B PMEL EDIL3 ASAH1 CTNNB1 CCNB1 AKT2 BCL2A1 HDAC1 DICER1 TCF7L1 MYO5A MAPK14 ATP6V1A ATP6V1H PXDN TNRC6A-1 CDH2 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis GFPT1 PGM1 DHDDS GNE GALM-2 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters TCF7L1 AXIN2 CTNNB1 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 PPP2R5E DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDK6 CDKN2A FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease ZMYM2 CBL FLT3 PTPN11 PIK3R1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation AKT2 RAB27A DCT MYO5A PMEL MAPK14 CTNNB1 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT MYH10 RHOA MYH9 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids MECR HADHA PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains CSK CD3G HLA-DPB1-1 PTPRJ HLA-DPA1 PTPN22 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed SENP1 SUMO1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 HDAC1 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway SNW1 HDAC1 HDAC5 MAMLD1 NOTCH3 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome BTRC PSMD8 PSMA6 RBX1 PRKACB-1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants FLT3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation FGF19 KLB INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism PPP2R5D PRKACB-1 KCNS3 TKT PRKAR1A PRKAR2A FASN ACSL3 KCNB1 AHCYL1 ADIPOR2 INS;INS-IGF2 KCNG2 FFAR1 TALDO1 ADRA2A RAP1A PRKAG2 ACLY ACACB GNA14 PFKFB1 GNB2 AKAP5 GNB1 GNB4 GNAI2 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation NMT1 SPR AKT1 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR14J1 OR10H1;OR10H5;OR10H2 OR4F21;OR4F16;OR4F29;OR4F3 OR7C1;OR7C2-9 OR8D1 OR6C76 OR5M10;OR5M1-1 OR5P2-4 OR10A4 OR4A47-3 OR10A5 OR2G6 OR51F1 OR2A7;LOC107987545;OR2A4 LHX2 OR4C11-1 OR12D3 OR8U8;OR8U1;OR8U9 OR2T12;OR2T33;OR2T8-1 LDB1 OR51E2 OR51M1 OR8I2 OR52W1 OR2T1 OR5V1-2 OR52D1 OR2AG1;OR2AG2 OR1I1 OR51B6 OR8H2;OR8H3;OR8H1 OR10K2 OR51I2 OR2T29;OR2T5-3 OR5P3 OR51I1 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels KCNJ3 KCNS3 KCNJ5 GABBR2 KCNJ10 KCNJ15 KCNN3 KCNB1 KCNK9 KCNG1 KCNG2 KCNH6 KCNC1 KCNMB1 KCNS2 KCNMB4 KCNAB1 KCNN2 KCNAB3 KCNK6 KCNK7 GNB2 KCNK10 KCNK2 KCNQ1 GNB1 KCNK4 GNB4 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC39A5 SLC30A3 SLC30A2 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening UBTF H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer TGFBR1-1 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade PIK3R4 IGF1 FLT3 KLB GAB1 IRS2 AKT2 FGF7 TRIB3 IGF2 FGF22 FGF19 PDE3B IRS1 PTPN11 FRS2 PIK3R1 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SNW1 JAG2 HDAC5 PSEN2 RBX1 MAMLD1 APH1A CDK8 PSENEN JAG1 HDAC1 MIB2 HES5 CCNC-1 ADAM17 MIB1 CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT PPP3CB BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 FGF7 FGF22 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling CAP2 ABL2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency BTD DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors S1PR3 LPAR5 S1PR2 LPAR1 LPAR2 LPAR3 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation UBE2V1 PELI1 IRAK1 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs RAD23A RAD23B SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis TSNAX DICER1 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC7A7 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling FGF22 PTPN11 FRS2 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS ADAMTS20 ADAMTSL5 THSD7A SEMA5A ADAMTS1 CFP THBS2 THSD4 ADAMTS10 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events DAD1 ZDHHC9 MGAT4B ST6GALNAC3 SUMO1 RPN2 STT3B RPN1 MGAT4A-1 MAGT1 GANAB ZDHHC3 MGAT5 ST3GAL4 ST6GAL1 ST3GAL1 ST3GAL3 EDEM2 ANO6 GOLGA7-1 SRPK1 TMEM258 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation ZC3H15 ETF1 F9 DRG1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex MPHOSPH8 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MORC2 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers PPP2R5B PPP2R5A PPP2R5D PPP2R5C HDAC5 CBX4 GATAD2A MKRN1 BMI1 PHC3 KIT AHCYL1 EZH2 IRS1 FRS2 PIK3R1 TNRC6A-1 PREX2 CSNK2B CSNK2A1;CSNK2A3 PDE1A PSMD8 PSMA6 BDNF PSMD12 EGFR PSMD11 FLT3 PSMB1 USP7 PSMC2-1 RNF146 KLB PSMA7 FRK IER3 MAPKAP1 CAMKK2 MAPK1 AKT2 AKT1S1 MDM2-2 AKT3 PHLPP1 TRIB3 IL33 EGR1 FGF19 SNAI1 STRN CAMK4 MYD88 AKT1 PIK3R5 PIP4K2C PRKACB-1 PRKAR1A MLST8 PRKAR2A IRAK1 IRS2 PIK3CG PTPN11 CAMK2B CAMK2D PML CAMK2A INS;INS-IGF2 LAMTOR2 CAMK2G HGF GAB1 AREG FGF7 HDAC1 FGF22 TSC2 KDM1A RBBP7 PPP2R5E JUN INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin EGFR INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors TCF19 HDAC1 IKZF1 ZMYND8-1 GATAD2A PCK1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 G6PC1 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion NGRN PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase KCNE5 KCNQ1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane PPP2R5D TRAF2 UBE2V1 TAB2 NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MEF2C MYD88 MAP3K8 JUN FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 SSRP1 GTF2F1 ELL ERCC3 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes ATP6V0A4 ATP6V1F ATP6V0D2 ATP6V1A NOS2 ATP6V1H CYBB CYBA TCIRG1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis RIPK1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants CAMK2A CAMK2G ARRB1 PHB APBB1IP MAP3K11 RAP1A MAP2K2;MAP2K1 FGB MAPK1 FGA CSK FGG CAMK2B CAMK2D KSR2 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes PCBP4 ZNF385A GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation PRKACB-1 GNB2 GNB1 PRKAR1A PRKAR2A GNB4 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants MAPK1 DUSP10 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT PPP2R5B PPP2R5A PPP2R5D PPP2R5C RHOA H2BC15;H2BC3;H2BC11;H2BC12 VANGL2 WNT10B AXIN2 TNRC6A-1 WNT8A CSNK2B CSNK2A1;CSNK2A3 PSMD8 PRKCB PSMA6 WNT7A PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 RNF146 DAAM1 PSMA7 AKT2 BTRC DKK1 AKT1 CTBP1 RBX1 SOX3 RSPO1 PRICKLE1 PPP3CB TMED5 GNAT2 DACT1 VPS26A PDE6B ZNRF3 PDE6A WNT5B LGR6 FZD4 LGR5 FZD7 WNT5A FZD6 CAMK2A SFRP1 TRRAP MEN1 RUVBL1 ZRANB1 HDAC1 TCF7L1 GNB2 KREMEN1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GNB1 AP2A1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNB4 AP2A2 FRAT2 PPP2R5E SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol ITPK1 NUDT11;NUDT10-1 IP6K3 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling IL33 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC DCC CASP3 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events TAAR5 FSHR TSHR GPHB5 SCT ARRB1 RXFP1 PRKACB-1 GIPR GPR83 PRKAR1A PRKAR2A DRD5 GRK6 GPR20 GPER1 PDE3B PTGIR GLP2R RAMP3 PTGER2 P2RY11 PDE11A PDE10A PDE1A GIP PDE7B RAMP1 GNAZ GNB2 RAMP2 GNB1 GNB4 GNAI2 HTR6 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis CERS1 MFSD2B CERS2 CERS3 SPHK1 CERS6 ORMDL1 KDSR SGMS2 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 TREX1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades FGB UNC93B1 FGA BTK TLR7 TLR4 S100A9 S100A1 FGG MYD88 LY96 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CSNK2A1;CSNK2A3 CDK5 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription SMAD4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction PTPN11 PIK3R1 CRK RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling TCF7L1 CTNNB1 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis SLC37A4 PC GAPDH-1 PCK1 ENO1 ENO2 G6PC1 FBP2 GPI DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins ST3GAL4 ST6GALNAC3 ST6GAL1 SUMO1 ST3GAL1 ST3GAL3 GANAB RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle GOLGA3 FNBP1 TXNL1 PTPN13 TNFAIP1 LEMD3 CKAP4 KTN1 ALDH3A2 VANGL2 KCTD13 PKP4 ANKRD26;CCDC144A;LOC105375816 NUDC PLXND1 PRAG1 FRS2 PIK3R1 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol INPP1 INPP4A MIOX SYNJ1 INPP5B MTMR7 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation ATR RAD9A DYRK2 PRKAG3 EXO1 CDK5 RFC5 RFC3 RFC4 RFC2 WRN RBBP8 RPA2 HIPK1 TAF7L RPA3 CSNK2B CSNK2A1;CSNK2A3 TAF12 TAF13 TP53RK TAF11 SSRP1 RHNO1 MDM2-2 PRKAG2 TAF7 CCNA1 TAF5 TAF2 BARD1 MAPK14 PIN1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols ARNT2 CYP11B1;CYP11B2 ARNT CYP7B1 CYP7A1 CYP39A1 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 TFDP1 TFDP2 HDAC1 CCNA1 PCNA CCNE1 LIN52 MYBL2 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHOA REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription TWIST2 H2BC15;H2BC3;H2BC11;H2BC12 STRAP MAPK1 HDAC1 MPHOSPH8 ZMYM2 FOXA2 SNAI1 EZH2 MCRIP1 KDM1A ZBTB33 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FOXP2 RBBP7 PKM H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KLF9 CTBP1 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP85 NUP88 SEC13 NUP133 NUP205 NUP107 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization H2BC15;H2BC3;H2BC11;H2BC12 DOCK1 EPS15 MPHOSPH8 BIRC2 EZH2 TNRC6A-1 CDH11 CSNK2B TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PVR PSMA7 MAPK1 MDM2-2 JAK1 BANP SNAI1 NECTIN2 CLDN1 MCRIP1 ZBTB33 FOXP2 PKM TYK2 KLF9 TMEM258 CTBP1 DAD1 ANG CLDN2 RPN2 CDH8 CDH6 RPN1 CDH3 ZC3H12A CDH12 CDH13 GANAB CDH19 CDH24 CADM2 CLDN23-1 SDK1 NECTIN4 FOXA2 NECTIN1 MPP5 CDH4 CDH2 CDH15 STRAP HDAC1 ZMYM2 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ILF3 HOXC8 CDC42 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer SMAD4 TGFBR1-1 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria ASL NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription HES5 MAMLD1 FCER2 GZMH;GZMB-1 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function WRN BARD1 RBBP8 PALB2 EXO1 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation FGB MAPK1 FGA CSK LAMTOR2 ARRB1 FGG APBB1IP RAP1A MAP2K2;MAP2K1 KSR2 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis FCSK SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 FGF19 KLB TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases CTSG MMP7 CMA1 COL18A1 MMP1 MMP9 MMP10 PLG PRSS3;PRSS2;PRSS1 MMP17 KLKB1 SPOCK3 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase FZR1 UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing INS;INS-IGF2 RAB27A ERO1B MYO5A CLTRN EXOC7 CPE DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A3 SLC30A2 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6A-1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane ARL2BP SLC29A4 SLC28A2 SLC29A3 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin IRS2 IRS1 PTPN11 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants CDC37 EGFR CBL PIK3R1 GAB1 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity RHOA DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine MPST CDO1 ETHE1 GADL1 SLC25A10 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response HSPA12B DNAJC2 NUP85 RPA3 HSPA9 DNAJC7 ATR NUP88 SEC13 NUP133 MAPK1 BAG2 NUP205 HSPA4L RPA2 NUP107 HSPA14 CCAR2 BAG3 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways SMAD4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTM1 PIK3R4 MTMR4 MTMR7 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK MAPK1 EGFR GAST CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism SLC37A4 NUP85 PPP2R5D NUP88 SEC13 PRKACB-1 NUP133 GCK PCK1 G6PC1 FBP2 GPI PFKP PC PFKFB2 GAPDH-1 PFKFB1 PFKFB4 ENO1 PFKFB3 ENO2 NUP205 NUP107 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy VPS11 VPS33A VPS33B VPS16 TUFM BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates LTC4S CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization NQO1 TADA1 SETD1B MCRS1 HMG20B SUMO1 GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 TADA2A YEATS2 KANSL2 FAM124B IGF2 CHD6 EZH2 AXIN2 SNRPA1 CTNNB1 MEAF6 SNRPF ING5 PCK1 G6PC1 SF3B6 PHF5A SNRPE-2 SNRPN SNRPG-2 CHERP PHF20 PUF60 SUV39H2 KDM5B SAP130 KDM5C PHF10 SETD3 TRRAP KDM1B SETD7 VPS72 TAF12 RUVBL2 RUVBL1 MYOG HCFC1 KMT5B SAP30 SSRP1 PBRM1 CTR9 KDM2A MYOD1 PRMT7 AEBP2 BCL11A ARID5B SUPT3H TCF19 MSL1 HDAC1 PWWP2B BRMS1 IKZF1 KAT6B PADI4 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 ZMYND8-1 KDM3A PWWP2A KDM3B SAP30L ADNP PADI6 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 BRD8 RBBP7 KDM4B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM4D PHF21A USP22 ELP1 ELP6 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling CETP APOC3 APOA1 APOE APOC2 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 CASTOR2 SZT2 LAMTOR2 SEC13 ATP6V1F SH3BP4 MLST8 BMT2 TCIRG1 NPRL2 WDR59 ATP6V0D2 ATP6V1A DEPDC5 ATP6V1H CASTOR1 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription POLR2L SNAPC1 SNAPC2 SSB POLR3A NFIB POLR3D POLR3F GTF3C2 POLR3K GTF3A BRF2 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling PRKACB-1 SIPA1 RAP1GAP2 RAP1A CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system SH2B3 CBL CAPZA1 CRK EIF2S2 HLA-DPB1-1 EIF2S3;EIF2S3B HLA-DPA1 NOS2 SOD2 CFL1 HNRNPA2B1 PDCD4 IL12B GSDMD TRAF2 SNRPA1 IL12A IL12RB1 IL12RB2 UBE2D3;UBE2D2 IL21 FLT3 MAP2K2;MAP2K1 TNFSF13B MAPK1 NPM1-2 EIF4E FANCC PIN1 MAP3K14 TNFRSF13B TNFSF15 TNFRSF9 EDA2R LTA TNFSF9 PML PLCG2 MT2A SUMO1 EIF3C;EIF3CL EIF3L EIF3E EIF3B FCER2 IL21R NANOG;NANOGP8 BTRC IL33 EGR1 ABL2 KPNA4-1 IP6K2 CASP3 CTSG MMP1 MMP9 ADAM17 ITGAM EIF4G3 IRF5 IL1R1 FLNA CSK H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 IL13 PTPN13 TNF BATF GBP2;GBP3;GBP1 CCL3L1;CCL3L3;CCL3;CCL18 BLNK BIRC2 TNFRSF1A BIRC3 MEF2C MAP3K8 ADAR PSMD8 PSMA6 PSMD12 PSMD11 TALDO1 PSMB1 PSMC2-1 PSMA7 HSP90B1 MAOA MAPK14 CSF2 AKT1 LIFR RBX1 IL2 NUP205 NUP107 CAMK2B CAMK2D CAMK2A NUP85 CAMK2G NUP88 PTPN7 IL34 SEC13 PTPRJ NUP133 UBA7 DDX58 PPP2R5A MUC1 PPP2R5D IFIT3 IRS1 PIK3R1 HSPA9 IL20RA RPS15 TBK1 AKT2 TOLLIP AKT3 TRIM8 RPS11 RPS13 JAK1 RNASEL IFNL2;IFNL3;IFNL1 RIPK2 IL10RB CA1 USP14 NKIRAS1 NKIRAS2 CRLF2 PELI1 MYD88 TYK2 IL13RA1 ILF2 UBE2V1 PTPN20 TRIM62 IL2RB TRIM38 NOD1 TRIM31 CSF2RA PTPN2 IFI35 IRAK1 EBI3 IL1R2 CRLF1 IRS2 PRLR IFNLR1 IL25 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL15 IL19 PTPN11 OSMR RPS25 RPS27 IL18R1 RPS29 RAG2 RAG1 IL17F TAB2 FAU ISG20 CASP1 IL7R RPS21 IRF6 RPS24 TRIM21 IL17A IRF9 GBP7;GBP4 TEC HGF LOC105377022;FANCB SPHK1 CCL22 CXCL8 CCL20 ILF3 JUN CDC42 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation CHAC1 GGT1 OPLAH GSTK1 GSTA3;GSTA5;GSTA1;GSTA2 MGST3 MGST1 GSTT1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation PIK3CG LOC102723996;ICOSLG PIK3R1 PIK3R5 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors CHRM5 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development EPHA5 ANK2 SHTN1 DOK6 SCN8A SPTBN4 L1CAM RGMB SPTB RGMA RHOA DSCAML1 DOK1 RELN ABLIM3 CAP2 CDK5 DOCK1 MYO10 LAMA2 TRPC6 RDX CFL1 PSMD8 PSMA6 EPHA4 PSMD12 PSMD11 DCC UNC5C MYH9 PSMB1 PSMC2-1 PSMA7 MAP2K2;MAP2K1 MAPK1 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 RPL35 RPL38 RPL39 SLIT3 RBX1 PRKACB-1 RPL22 PRKAR2A CNTN6 ANK1 RPL29 LDB1 PSEN2 APH1A ITGAV PSENEN AKAP5 SEMA5A AP2A1 AP2A2 RANBP9 CACNA1H MSI1 GSPT1 SLIT1 HOXA2 LHX2 COL4A5 GDNF RPL18 ETF1 PLXND1 FRS2 COL4A4 PIK3R1 COL6A3 CSNK2B CSNK2A1;CSNK2A3 EGFR RPL37A-1 RPS15 RPS11 RPS13 PLXNA1 ABL2 SRGAP2 MYH10 SRGAP1 ARPC4 ADGRG6 PTK2 MBP ACTR3-1 PMP22 IRS2 PPP3CB SPTAN1 MMP9 GIT1 SEMA7A ARHGEF11 ACTR2 CRMP1 DPYSL5 DPYSL2 RPL7A DPYSL3 PLXNA2 PTPN11 PLXNB3 RPS25 RPS27 RPS29 EVL FAU RPS21 RPS24 GAB1 PRNP CACNA1I SH3KBP1 SCN11A EPHB1 EPHB4 EPHB3 CDC42 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes CYB5R2 CYB5R1 CA1 CA2 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system RDH12 OPN1SW INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling ADAR ISG20 IRF6 IP6K2 IRF9 IFIT3 GBP2;GBP3;GBP1 IFI35 EGR1 RNASEL JAK1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IRF5 PTPN11 TYK2 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication ORC1 ORC2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids TSPOAP1 TXNRD1 CIDEC PTPN13 CDK8 FABP4 RAB14 FASN SCD MED31-1 ACSL3 CERK MFSD2B PTGDS CPT1A CYP39A1 INPP4A TRIB3 ACACB PI4K2B PHYH-4 PIK3R5 NEU3 INPP5F ARSJ PIP4K2C NEU1 ARSH ACOT9 ARSI STARD3 B4GALNT1 PRKACB-1 MECR STARD5 DECR2 CTSA MED8 SLC10A2 ACER3 HACD1 MOGAT3 MTMR4 MOGAT1 TECR MTMR6 AKR1B1 MTMR7 HSD11B1 UGT8 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 TNFAIP8L1 STARD3NL PPT1 CYP7B1 LGMN PRKAG2 AACS GDPD1 HEXB HSD17B4 MCEE FITM1 SMPD1 GDPD5 CYP7A1 ELOVL1 ACOT2;ACOT1 ELOVL6 ARNT2 PTGR2 ORMDL1 PLEKHA6 MTF1 VDR PNPLA4 CBR1-1 ACAA2 SLC44A2 PITPNB ASAH1 CPNE6 MED28-1 PLA2G3 SGMS2 PGS1 PTDSS2 GPAT4 SC5D GGT1 PTPMT1 CPNE3 GPAT2 ACOT12 CHKB DGAT2 MBOAT7 STARD10 PLAAT3 DPEP1 GPCPD1 CRLS1 ABHD3-2 HADHA FABP3 PHOSPHO1 PIK3R1 FABP5 ETNK2 DHRS7B LPCAT4 FABP6 ETNK1 CSNK2B CYP2D6;LOC107987479;LOC107987478-1 CRAT PNPLA3 ACBD6 CHPT1 CSNK2A1;CSNK2A3 SLC27A1 LPIN1 MGLL FADS2 PLA1A CYP4F3;CYP4F2;CYP4F12;CYP4F11 PPP1CC AMACR FADS1 ABCD3 ACLY SLC27A5 ABHD5 A4GALT MTM1 PSAP HACL1 KDSR THRAP3 PIK3R4 ESRRA M6PR B4GALT6 SYNJ1 PON3 PTGES3-1 PON2 PON1 LTC4S FHL2 HMGCL ST3GAL3 PIK3CG TGS1 PIK3C2B ME1 MBTPS1 SGPP2 LBR MED16 CYP11B1;CYP11B2 MED17 CERS3 CERS6 GGPS1 APOA2 APOA1 ARNT NCOA6 ELOVL5 SLC25A17 MED23 MED24 ST6GALNAC5 PLIN2 CERS1 CERS2 SPHK1 CCNC-1 MORC2 PPARGC1B SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions SLC13A5 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC44A2 SLC25A10 SLC22A12 SLC10A6 EMB SLC16A3 SLCO4C1 SLCO1C1 SLCO4A1 SLCO2B1 SLC16A2 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs FLT3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD PSMD8 PSMA6 PSMD12 PSMD11 SYVN1 PSMB1 PSMC2-1 PSMA7 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis POLA2 RFC3 RFC4 RFC2 POLD4 PCNA RFC1 RFC5 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport VDAC1 PMPCB SPG7 PHB VDAC3 MICU1 SLC8B1 PHB2 MCU PARL AKAP1 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway HNF4A ESRRB AR VDR RARA NRBP1 ESRRA PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes AKAP8L PSIP1 SETD1B MCRS1 MEN1 BOD1L2;BOD1 NCOA6 HCFC1 TADA2A YEATS2 KANSL2 CXXC1 PHF20 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis CSPG5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 SEC13 PPP1CC NUP133 DYNC1I2 CENPA NSL1 DYNC1H1 SKA1 SKA2 CENPF CENPI TAOK1 NEK9 CENPM PPP2R5E NEK6 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly MTTP APOB APOA2 APOC3 APOA1 APOE APOA4 APOC2 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs BARD1 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis TFDP1 GMNN MYB DEUP1 MCIDAS GMNC TNRC6A-1 CCNO BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism ABCD3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC27A5 HSD17B4 STARD5 CYP7B1 CYP7A1 CYP39A1 AMACR SLC10A2 FABP6 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions H2BC15;H2BC3;H2BC11;H2BC12 DOCK1 EPS15 MPHOSPH8 BIRC2 EZH2 TNRC6A-1 CDH11 CSNK2B TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PVR PSMA7 MAPK1 MDM2-2 JAK1 BANP SNAI1 NECTIN2 MCRIP1 ZBTB33 FOXP2 PKM TYK2 KLF9 TMEM258 CTBP1 DAD1 ANG RPN2 CDH8 CDH6 RPN1 CDH3 ZC3H12A CDH12 CDH13 GANAB CDH19 CDH24 CADM2 NECTIN4 FOXA2 NECTIN1 CDH4 CDH2 CDH15 STRAP HDAC1 ZMYM2 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ILF3 HOXC8 CDC42 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis PPCS AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PRKAG2 PSMD8 PSMA6 ERLIN1 ERLIN2 PRKAG3 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex PPP2R5B PPP2R5A PPP2R5D PPP2R5C PSMD8 RBX1 PSMA6 PSMD12 PSMD11 PSMB1 ZRANB1 CTNNB1 PSMC2-1 PSMA7 BTRC HDAC1 TCF7L1 FRAT2 CTBP1 PPP2R5E ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) ATRX SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT KIT G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events PRKCH GNAZ RGS17 PRKCB GNB2 GNB1 ADRA2A GNB4 GNAI2 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) SC5D LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors LTB4R2 CYSLTR1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol ITPK1 PLCD1 ITPKB PLCG2 PLCB4 PLCZ1 PLCH2 SYNJ1 INPP5B NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity STAM2 SH3KBP1 EPS15 PTPRJ CBL HGF PTPN2 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation ADH4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions DCC DSCAML1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking GOPC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins PRKACB-1 GNB2 MYO5B GNB1 PRKAR1A PRKAR2A GNB4 RAB11A ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins PRSS3;PRSS2;PRSS1 ART1 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway TBK1 DDX58 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants SPRED3 SPRED2 SPRED1 NF1 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation TASL IRF5 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) IRS1 PIK3R1 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin IRS2 PLCG2 PIK3CG PIK3R1 PIK3R5 GAB1 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII CDC37 EGFR CBL PIK3R1 GAB1 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network COG8 RHOBTB3 COG6 COG2 GCC2 VPS52 ARFIP2 M6PR NAA30 COG1 RAB9A NAA38 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling STRAP PPP1R15A USP15 PPP1CC MTMR4 TGFBR1-1 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGB PYGM PGM1 AGL-1 PYGL GAA REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6A-1 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose GMPPA DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity CDK6 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins CTSG CPB2 CMA1 CPA3 ENPEP CPB1 ACE ANPEP RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development MAPK1 SMAD4 AR UCMA RBM14 MAF SATB2 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells PDX1 PTF1A TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses TSPOAP1 COMT RIMS1 PPFIA4 CPLX1 GLUL PPFIA3 PPFIA2 PRKCB CAMKK2 MAPK1 MDM2-2 MAOA CAMK4 MYO6 GABRB3 GRIK5 GLS CHRNA9 GRIK4 LIN7C NRGN GABRR3 SLC18A3 CHRND GABRR2 GABRR1 GLRA3 PRKAG3 PRKACB-1 KCNJ3 KCNJ5 GABBR2 KCNJ10 PRKAR1A GABRA4 PRKAR2A KCNJ15 GRIN3B GRIN3A GLRB RASGRF2 LRRC7 GIT1 CAMK2B CAMK2D CAMK2A CACNA2D1 CAMK2G CACNA1B CACNG3 ALDH5A1 CHRNB2 PRKAG2 GLS2 GNB2 AKAP5 GNB1 AP2A1 GNB4 GNAI2 LRTOMT RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation CSNK2B CSNK2A1;CSNK2A3 PPP1CC SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 NUP88 SEC13 NUP133 GCK NUP205 NUP107 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis IDH2 MTERF1-1 ESRRA NCOA6 TWNK CRTC1 TFB2M GLUD1;GLUD2 HCFC1 POLG2 PERM1 TGS1 CAMK4 MEF2C SOD2 CRTC3 PPARGC1B RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 MAPK1 SHTN1 L1CAM DPYSL2 AP2A1 RDX AP2A2 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport ANK2 INS;INS-IGF2 SPTBN4 SPTB DYNC1I2 DCTN2 TMED7 TMED9 CAPZA1 COG1 ACTR1A GOLGA2 ANK1 KDELR2 COG8 DCTN1 COG6 SPTAN1 DYNC1H1 COG2 BET1L RAB1B GORASP1 ACTR10 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade FGB FGA F10 F11 FGG F2 F9 ANO6 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRT20 KRT18 KRT15 KRT74 DSP KRT3;KRT76 KRT85 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 PKP4 PERP KLK5 KLK14 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 LIPJ LIPN PKP1 SPINK9 LIPK IVL KRT16;KRT14 KRT4 KRT2 KRT8 KRT9 KRTAP16-1 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds CYP2D6;LOC107987479;LOC107987478-1 ARNT2 ADH4 CYP11B1;CYP11B2 EPHX1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ARNT CYP7B1 CYP39A1 POR PTGES3-1 CYP2S1 CES2 FMO2 MAOA MTARC1 CYP7A1 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants CAMK2A CAMK2G ARRB1 APBB1IP RAP1A MAP2K2;MAP2K1 FGB MAPK1 FGA CSK FGG CAMK2B CAMK2D KSR2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma AKT2 AKT3 GNB2 PIK3CG GNB1 RHOA GNB4 AKT1 PIK3R5 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 SSRP1 GTF2F1 ELL ERCC3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators COLEC10 C1QB MASP1 C1R C1QC CRP DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER AREG MIA2 LMAN2 SEC22B PREB MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation MRPS17 MRPS16 MRPS33 MRPL18 MRPL19 MRPS31 MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 CHCHD1 MRPS28 PTCD3 TSFM MRPS23 MRPL49 MRPS2 MRPL47 MRPS7 MRPL43 MRPL21 LOC107987373;MRPL23 MRPL52 MTRF1L TUFM LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome HDAC1 CAMK4 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere ATRX SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) JAK1 UBE2D3;UBE2D2 PTPN11 TYK2 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids TSPOAP1 ELOVL6 STARD3 MTF1 VDR STARD5 SLC10A2 SC5D SCD FASN TGS1 AKR1B1 MBTPS1 FABP6 HSD11B1 LBR CYP11B1;CYP11B2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 GGPS1 STARD3NL NCOA6 CYP7B1 CYP39A1 AMACR LGMN ABCD3 ACACB SLC27A5 HSD17B4 CYP7A1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNB1 BTRC CCNA1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 GNB2 GNB1 GNB4 CDC42 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism PYCR3 GLUL GLS2 GLUD1;GLUD2 GLS PYCR2 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines MTHFD1 SLC46A1 ALDH1L1 SLC19A1 FOLR2 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism ADA DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 ACAN MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B3 SLC26A2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins SRGAP2 PPP2R5B PPP2R5A PPP2R5D B9D2 SCAI PPP2R5C DIAPH3 RHOA KIF18A KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 RHOD EVL SEC13 PPP1CC NUP133 DYNC1I2 CENPA NSL1 DAAM1 DYNC1H1 SKA1 SKA2 CENPF CENPI TAOK1 CENPM CDC42 PPP2R5E RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes CEP63 TUBGCP5 TUBGCP6 TUBGCP4 CDK11A;CDK11B DYNC1I2 DCTN2 SSNA1 CEP164 ACTR1A TUBA1A CEP250 CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 NEDD1 CENPJ ALMS1 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) POLR2L COPS7B RPA3 COPS7A POLD4 RFC1 GTF2H3 POLR2G RBX1 DDB1 COPS8 USP7 ISY1;ISY1-RAB43 RFC5 ERCC3 RFC3 RFC4 XAB2 GTF2H2C;GTF2H2C_2;GTF2H2 RFC2 PCNA RPA2 ELL RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport APOA2 APOC3 APOA1 SDC3 APOE APOA4 APOC2 CLPS GPC3 GPC2 APOB GPC4 RETSAT DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations CRPPA LARGE2 FKTN POMK SLC35A1 SLC35A4 FKRP RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle SRGAP2 RACGAP1 MCAM ERBIN DIAPH3 NOXA1 NOX3 LEMD3 JAG1 EMD GIT1 RAB7A PIK3R1 ARAP2 LBR PREX1 ARHGAP42 BAIAP2L1 CDC42EP1 OPHN1 CYBB CYBA SLITRK3 NHS BCR SLITRK5 ARHGAP17 WASF2 ARHGAP15 ABI2 ABL2 CDC42 NCKAP1L WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL CSNK2B CSNK2A1;CSNK2A3 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis C1QBP SOD2 CDK5 GOLGA2 JUN TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TRAF2 BIRC2 MAP3K14 BIRC3 LTA TNFSF13B DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations ATRX TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production NSMAF TNFRSF1A TNF ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway TAB2 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization H2BC15;H2BC3;H2BC11;H2BC12 DOCK1 EPS15 MPHOSPH8 BIRC2 EZH2 ITGB4 TNRC6A-1 CDH11 CSNK2B PLEC TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 ACTN1 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PVR PSMA7 MAPK1 MDM2-2 JAK1 BANP SNAI1 NECTIN2 CLDN1 MCRIP1 ZBTB33 FOXP2 PKM TYK2 KLF9 TMEM258 CTBP1 DAD1 COL17A1 ILK ANG PARVA TESK1 CLDN2 RPN2 CDH8 CDH6 RPN1 CDH3 ZC3H12A CDH12 CDH13 GANAB CDH19 FBLIM1 CDH24 CADM2 PARVB CLDN23-1 SDK1 NECTIN4 FOXA2 NECTIN1 MPP5 CDH4 CDH2 CDH15 STRAP FLNA HDAC1 ZMYM2 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ILF3 HOXC8 CDC42 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A9 SLC26A2 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission LRRC7 CAMK2A CAMK2G CAMK4 CAMK2B CAMK2D DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA ALDH5A1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling IL12B IL12A IL1R1 TNF CCL3L1;CCL3L3;CCL3;CCL18 IL1R2 JAK1 IL10RB TNFRSF1A CCL22 CXCL8 FCER2 CCL20 CSF2 TYK2 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer SNW1 JAG2 HDAC5 PSEN2 RBX1 MAMLD1 APH1A CDK8 PSENEN JAG1 HDAC1 MIB2 HES5 CCNC-1 ADAM17 MIB1 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism ENTPD4 ENTPD8 GDA XDH PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways ARPC4 PTK2 PRKACB-1 NOXA1 PRKAR1A ACTR3-1 PRKAR2A CRK DOCK1 CTSG GGT1 MYO10 AHCYL1 MYO5A ADAM17 ACTR2 DPEP1 FZD7 WNT5A WIPF3 GSDMD PYCARD PLCG2 P2RX7 CASP1 WAS SUGT1 CYBA MYH9 MAPK1 C3AR1 BTK P2RX4 GNAZ WASF2 CD3G WASF3 CYSLTR1 GNB2 MAPK14 GNB1 ABI2 GNB4 GNAI2 CDC42 NCKAP1L JUN MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) HSPA9 LONP1 SOD2 AKT1 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK RFC3 RFC4 RPA3 MAD2L2 RFC2 REV1 PCNA RFC1 RPA2 RFC5 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis SC5D LBR GGPS1 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import ABCD3 FIS1 PEX12 SLC25A17 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions ANK1 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division MAU2 SMC3 STAG2 WAPL METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se TXNRD1 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) PPP2R5D TRIB1 RHOA RAP1A CDK5 CRK MAP2K2;MAP2K1 MAPK1 IRS2 EGR1 ID4 MAPK14 TPH1 IRS1 MEF2C AP2A1 FRS2 PIK3R1 AP2A2 RIT2 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling DAD1 ERLIN1 RBX1 RPN2 EPAS1 PRKAG3 PDCD1LG2 ERLIN2 RPN1 H2BC15;H2BC3;H2BC11;H2BC12 BRD4 MIB2 EZH2 HLA-DPB1-1 HLA-DPA1 PTPN11 TNRC6A-1 CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 STT3B PSMD12 PSMD11 TEAD2 TEAD3 TEAD4 PSMB1 MAGT1 CTNNB1 PSMC2-1 PSMA7 PRKAG2 CSK BTRC CD3G JAK1 TCF7L1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUN TMEM258 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body LMBRD1 TCN2 TCN1 CD320 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation PSIP1 XRCC4 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade SDC3 GPC3 PF4;PF4V1-1 SERPINE2 GPC2 F10 F12 GPC4 F11 F2 F9 SMPD1 ANO6 KLKB1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules RTN3 PTPRD ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes PPP2R5A KPNA4-1 SUMO1 IFIT3 GBP2;GBP3;GBP1 PTPN2 EIF3C;EIF3CL EIF3L EIF2S2 EIF3E EIF2S3;EIF2S3B EIF3B EIF4G3 NUP205 NUP107 RPS25 RPS27 NUP85 RPS29 ADAR NUP88 CASP1 SEC13 FAU NUP133 RPS21 RPS24 RPS15 LOC105377022;FANCB FLNA NPM1-2 RPS11 SPHK1 RPS13 RNASEL JAK1 UBA7 EIF4E DDX58 FANCC ILF3 ILF2 PIN1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha AJUBA PSMD8 UBE2D3;UBE2D2 RBX1 PSMA6 EPAS1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 HIF3A LIMD1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 MLLT3 POLR2G GTF2H3 SUPT6H SSRP1 CTR9 GTF2F1 AFF4 ELL ERCC3 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation PRKACB-1 PRKAR1A PRKAR2A POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events CAMK2A NRGN CAMK2G PRKAG3 PRKACB-1 PRKAR1A PRKAR2A RASGRF2 CAMKK2 LRRC7 MAPK1 PRKAG2 GIT1 CAMK4 CAMK2B CAMK2D G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint RPA3 ATR RAD9A HERC2 H2BC15;H2BC3;H2BC11;H2BC12 EXO1 RHNO1 RFC5 CCNB1 RFC3 RFC4 RFC2 CCNA1 WRN BARD1 RBBP8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RPA2 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway ENOPH1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis ATP6V1H HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E AP2A1 AP1S3 AP2A2 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks APBB1 SUMO1 BARD1 HERC2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KDM4B EYA1 EYA3 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) OPN1SW FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm PAX8 LHX1 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy TBK1 CSNK2B MFN1 VDAC1 UBE2V1 CSNK2A1;CSNK2A3 MFN2 UBE2D3;UBE2D2 VDAC3 TOMM7 ATG5 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling FSHR TSHR GPHB5 RHOA DRD4 DRD5 CDK5 AHCYL1 PDE3B TRPC6 PDE11A PDE10A PDE1A TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 CAMKK2 MAPK1 C3AR1 NPY CAMK4 TAS2R39 AKT1 PIK3R5 TAS2R7 TAS2R8 TAS2R1 TAS2R4 PRKACB-1 GABBR2 PRKAR1A PRKAR2A TAS1R1 TAS1R3 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 MCHR1 CAMK2B CAMK2D CAMK2A CAMK2G FFAR1 F2 RAMP2 GNAI2 HTR6 TAAR5 PPP2R5D SCT RXFP1 RGS8 PLCB4 GPR37L1 DAGLA DGKB CHRM5 CENPS-CORT;CORT;CENPS TAS2R42 MLN GIPR GPRC6A RGS2 GPR83 NPBWR1 BDKRB2 GALR1 BDKRB1 NPBWR2 GAST PROK1 GRK6 PRKCH DGKZ OPN3 LTB4R2 PPP1R1B DGKK PNOC GPSM1 RGS17 GPR20 GRP LPAR1 GPER1 LPAR2 GRM8 LPAR3 GPSM3 LPAR4 PTGIR PROKR1 GLP2R P2RY2 RAMP3 P2RY1 PIK3R1 TAC3 PTGER2 OPN4 PTGER3 NMB CCL4L2;CCL4L1;CCL4 P2RY11 XCL1;XCL2 S1PR3 PREX1 RGS22 CCK LPAR5 S1PR2 NMS P2RY13 GPR55 FFAR3;GPR42 PRKCB MGLL F2RL2 APLN GIP EGFR PDE7B RAMP1 AKT2 BTK AKT3 GNAZ CYSLTR1 OPN1SW PSAP ARRB1 RASGRF2 PPP3CB GNAT2 ARHGEF11 PIK3CG ARHGEF15 ARHGEF17 ADRA2A GNA14 CCL13;CCL2 GNB2 CXCL8 AVPR1B GNB1 CCL20 CXCL5;CXCL6 GNB4 CDC42 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis LALBA REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABHD10 SLC35D2 UGT2A1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation HDAC5 CBX4 GATAD2A MKRN1 BMI1 PHC3 MLST8 EZH2 TNRC6A-1 PML PREX2 CSNK2B LAMTOR2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 USP7 PSMC2-1 RNF146 PSMA7 FRK MAPK1 AKT2 AKT3 HDAC1 EGR1 SNAI1 KDM1A RBBP7 AKT1 JUN PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation PSAP PLG LGALS3BP PECAM1 WDR1 IGF1 OLA1 LEFTY2;LEFTY1 SYTL4 NHLRC2 ENDOD1 CLEC3B APOH MANF CALU IGF2 CYB5R1 CD9 SELP CFD ORM2;ORM1 CD63 CFL1 APOA1 ACTN1 TGFB2 HGF FGB FLNA FGA FGG TTN-1 LAMP2 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX36 MYD88 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus PSIP1 XRCC4 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK IRS1 PIK3R1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy PLIN2 LAMP2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 PPP2R5E CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels KCNMB1 KCNMB4 KCNN2 KCNN3 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K IRS1 PIK3R1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling MUC1 IL12B IL12A IL17F IL13 IL17A TNF BATF HGF NANOG;NANOGP8 MMP1 MMP9 JAK1 HSP90B1 CCL22 MAOA ITGAM CXCL8 NOS2 FCER2 TYK2 PIK3R1 AKT1 IL13RA1 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions FLNA PARVB ILK PARVA TESK1 ACTN1 FBLIM1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases CAMK2A PDZD11 CAMK2G ATP9B ATP8B3 ATP13A1 ATP1B3-1 ATP2B2 FXYD2;FXYD6-FXYD2 ATP2B1 ATP8A1 ATP4B ATP12A ATP4A ATP11B ATP1B1 ATP1A1 CAMK2B CAMK2D REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors AKT2 AKT3 AKT1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA TBK1 NLRP4 TREX1 TRIM21 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor GNA14 GNB2 GNB1 GNB4 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 CBL DOK1 AKT1 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR KDR DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification TRMT61B LRPPRC NGRN ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones ARID5B KDM5B KDM5C KDM3A KDM3B KDM1B KDM1A KDM4B KDM4D H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM2A TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade TLR7 PPP2R5D UBE2V1 RBSN PIK3R4 NOD1 IRAK1 TASL IRF5 MEF2C MAP3K8 LY96 TRAF2 TLR4 TAB2 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors SCT GNB2 GIP GIPR GNB1 GLP2R GNB4 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis TFDP1 TFDP2 DSP PTK2 SATB1 GZMH;GZMB-1 CASP3 C1QBP GSDME SPTAN1 BIRC2 PKP1 LY96 FAS RIPK1 GSDMD PLEC TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TLR4 PSMD8 PSMA6 PSMD12 PSMD11 DCC PSMB1 CTNNB1 PSMC2-1 PSMA7 MAPK1 NMT1 AKT2 AKT3 H1-3 H1-2 MAPT CLSPN H1-5 AKT1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes INS;INS-IGF2 SMAD4 NPY HDAC1 GCK AGRP NR3C1 PCK1 SOD2 G6PC1 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development HNF4A LHX1 JAG1 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria TFDP1 TFDP2 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas FGF7 LAMA2 LAMB2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SNW1 JAG2 HDAC5 PSEN2 RBX1 MAMLD1 APH1A CDK8 PSENEN JAG1 HDAC1 MIB2 HES5 CCNC-1 ADAM17 MIB1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle TSPOAP1 RIMS1 PPFIA4 SLC18A3 CPLX1 PPFIA3 PPFIA2 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid ADH4 SDR16C5 DHRS9 CRABP1 RARA RDH14 FABP5 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis DHRS7B DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair RPA3 ATR RAD9A PALB2 EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 RBBP8 RPA2 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling FGF22 SPRED2 SPRED1 FGFRL1 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction MPP5 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling EGFR PIK3R1 GAB1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling EGFR HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones TADA1 MCRS1 ING5 H2BC15;H2BC3;H2BC11;H2BC12 TADA2A YEATS2 KANSL2 PHF20 SAP130 TRRAP VPS72 TAF12 RUVBL2 RUVBL1 HCFC1 MEAF6 SUPT3H MSL1 KAT6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 BRD8 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 USP22 ELP1 ELP6 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion HHAT PSMD8 PSMA6 PSMD12 PSMD11 SYVN1 PSMB1 PSMC2-1 PSMA7 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis NMT1 MAPK1 GSDMD TFDP1 AKT2 C1QBP GSDME AKT3 TFDP2 GZMH;GZMB-1 CASP3 AKT1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 UBE2V1 TAB2 RIPK2 NOD1 IRAK1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells GLUL RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration AKT2 AKT3 AKT1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies AACS HMGCL INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR AREG EGFR RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression CPT1A TGS1 NCOA6 NRIP1 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants CAMK2A CAMK2G ARRB1 PHB APBB1IP MAP3K11 RAP1A MAP2K2;MAP2K1 FGB MAPK1 FGA CSK FGG CAMK2B CAMK2D KSR2 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism LMBRD1 MMAB TCN2 CD320 MTR-1 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal MGMT ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) IRS2 PLCG2 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP SMAD4 BMPR1B BMPR1A BMPR2 AMH CER1 SMAD5 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 SEC13 PPP1CC NUP133 DYNC1I2 CENPA NSL1 DYNC1H1 SKA1 SKA2 CENPF CENPI TAOK1 CENPM PPP2R5E DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism HIBCH BCKDHB AUH BCKDK PPM1K RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy CSNK2B CSNK2A1;CSNK2A3 ATG5 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants CAMK2A CAMK2G ARRB1 PHB APBB1IP MAP3K11 RAP1A MAP2K2;MAP2K1 FGB MAPK1 FGA CSK FGG CAMK2B CAMK2D KSR2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair RPA3 PARG POLB POLD4 RFC1 PARP2 TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 RFC5 RFC3 RFC4 RFC2 PCNA NTHL1 TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RPA2 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones PPP2R5B GFPT1 ERN1 DCTN1 CXXC1 KLHDC3 SYVN1 PREB YIF1A SEC31A MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB6 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules SLC5A1-1 CETP APOC3 SLC40A1 APOC2 HEPH SLC35B3 SLC46A1 EIF2S2 EIF2S3;EIF2S3B MYO5B AQP6 ATP6V1H TRPC6 TRPV6 TRPV4 TRPM8 TRPM4 PDZD11 PSMD8 PSMA6 SLC7A7 PSMD12 SLC7A8 PSMD11 SLC7A11 RSC1A1 SLC38A3 PSMB1 PSMC2-1 PSMA7 SLC5A6 MTTP VDAC1 APOC1 APOB SLC10A6 VDAC3 SLC35D2 RHBG PRKACB-1 APOE PRKAR1A PRKAR2A SLC35A1 CYB5R2 CYB5R1 SLC16A3 SLC25A26 SLC47A1 CAMK2B CAMK2D RAB11A CAMK2A SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CAMK2G APOBR AP2A1 AP2A2 ARL2BP SLC27A6 SLC29A4 SLC28A2 SLC29A3 PMPCB SPG7 PHB MICU1 PHB2 SLC44A2 MCU SLC17A8 PARL ATP8A1 TCIRG1 ATP12A TSC22D3 ATP11B ATP1B1 ABCA2 SLC9B2 ABCA8 SLC9A2 SCNN1G ABCF1 SLC9A3 SCNN1D SLC9A4 SCNN1B EMB ATP6V0D2 ATP6V1A TTYH2 ATP1A1 CLCN3 CLCN2 CLCN1 ASIC4 BSND CLCA1 ATP6V0A4 SGK3;C8orf44-SGK3 ASIC2 SLC27A1 ATP9B ASIC3 ATP6V1F ATP8B3 ATP13A1 SLC8B1 SLC4A3 ATP1B3-1 SLC2A4 FXYD2;FXYD6-FXYD2 TPCN2 MAGT1 TPCN1 CLCN7 ATP4B CLCN6 ATP4A ABCD3 MRS2 CLCN5 AZGP1 CLCN4 NIPAL1 NIPA1 CA1 SLC26A2 SLCO4C1 CA2 ANO6 ABCB6 SLC9A1 ERLIN1 ERLIN2 SLC6A5 SLC6A2 FTH1 SLC30A3 SLC30A2 ACO1 SLC39A5 ATP6AP1 SLCO1C1 SLCO4A1 FTMT SLCO2B1 MBTPS1 SLC16A2 SLC13A5 SLC26A9 SLC5A4 SLC13A1 SLC2A12 APOA2 CPTP APOA1 SLC20A1 SLC12A6 SLC31A1 APOA4 ATP2B2 SLC25A18 ATP2B1 SLC8A1 SLC8A2 SLC25A10 STOM SLC22A12 GNB2 SLC22A18 GNB1 GNB4 SLC20A2 AKAP1 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing POLR2L PRPF6 SNRPF SNRNP35 SNRPE-2 POLR2G SNRPG-2 PRPF8 SNRNP25 SF3B6 GTF2F1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation SNW1 TFDP1 ELF3 TFDP2 E2F3 MAMLD1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NOTCH3 TNRC6A-1 JUN NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription TWIST2 H2BC15;H2BC3;H2BC11;H2BC12 MAPK1 HDAC1 MPHOSPH8 ZMYM2 SNAI1 EZH2 MCRIP1 KDM1A ZBTB33 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 PKM H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CTBP1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids PON2 PON1 LTC4S PON3 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase TFDP1 E2F2 TFDP2 CDKN2B CDK6 E2F3 CCNE1 CDKN2A PTK6 CDKN2D CDKN2C PPP2R2A;PPP2R2D BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 ST3GAL6 ST3GAL3 B3GALT2 B4GALNT2 FUT9 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) SCT WNT7A GIP GIPR SMO RAMP1 WNT10B GNB2 FZD4 RAMP2 FZD7 GNB1 WNT5A GLP2R RAMP3 FZD6 GNB4 WNT8A ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation ANK2 DHDDS ST3GAL6 SPTBN4 RAD23B SPTB CAPZA1 GOLGA2 NAGK AMDHD2 GFPT1 RENBP DCTN1 SEC22B MGAT3 MIA2 EDEM3 NUDT14 RNF103 DYNC1I2 RNF139 TRIM13 DCTN2 MGAT4A-1 SYVN1 UGGT2 MAGT1 UGGT1 ACTR1A FCSK DOLPP1 GMPPA COG8 GNE COG6 DYNC1H1 ST6GAL1 COG2 BET1L ACTR10 CSNK1D TMEM258 DAD1 NEU3 NEU1 ST6GALNAC3 RPN2 RPN1 B4GALNT2 CTSA B4GALT6 GANAB SLC35A1 MGAT5 ANK1 ST3GAL4 MAN1A1 SPTAN1 ST3GAL1 RAB1B ST3GAL3 EDEM2 INS;INS-IGF2 TRAPPC4 MGAT4B TRAPPC10 SEC13 STT3B TRAPPC6A TRAPPC6B ALG8 TMED7 TMED9 ALG3 COG1 PREB SEC31A AREG KDELR2 ST6GALNAC5 ANKRD28 PPP6C SEC23IP GORASP1 LMAN2 SEC22C DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex AKT2 SOX3 BTRC HDAC1 TCF7L1 MEN1 CTNNB1 AKT1 CTBP1 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions CRLF1 JAK1 LIFR TYK2 OSMR SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways SNW1 TFDP1 ELF3 TFDP2 ST3GAL6 E2F3 MAMLD1 EPAS1 PTK6 MKRN1 CBL RHOA DOK1 SFPQ-1 DRD4 STAP2 RASGEF1A DRD5 CRK ETV4 DOCK1 MAPK4 FASN ESRP1 HNRNPA1-1 EPS15 DDX39B TRPC6 FGFRL1 FAS RIPK1 TRAF2 PDE11A TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PDE10A PDE1A UBE2D3;UBE2D2 BDNF FLT3 TGFBR1-1 RNF146 RAP1A MAP2K2;MAP2K1 FRK CAMKK2 MAPK1 C3AR1 APOC1 EIF4E EIF4B GABRB3 PIP4K2C GABBR2 LRRC7 SPPL2B SPPL2A OTULIN NSMAF MCHR1 TPH1 MTMR4 ADH4 PPP1R15A USP15 PLCG2 BMPR2 PSEN2 STRADA ACVR1B APH1A CAB39L ITGAV AMH CER1 PSENEN MYOG TGFB2 SMAD5 MYOD1 STRAP PRKAG2 BMPR1B THBS4 BMPR1A SMC3 DZIP1 STAG2 NRIP1 TFF1 FKBP4 TEK PLCB4 GZMH;GZMB-1 COL4A5 CAV2 EIF4EBP1 COL4A4 FABP5 FABP6 COL6A3 PPP1CC SYVN1 KLB IER3 AKT1S1 PHLPP1 IL33 EGR1 FGF19 SNAI1 STRN DKK1 CTBP1 JAG2 PSAP APBB1IP MRAS SOX3 RSPO1 HHAT TMED5 DACT1 VPS26A ZNRF3 LGR6 PIK3CG LGR5 DUSP10 KSR2 LBR KDR CILP BEX3 ADRA2A GRAP PPID LATS1 SH3KBP1 AVPR1B KREMEN1 MIB1 PTPN13 APOC2 HES5 AHCYL1 PDE3B MTR-1 TRIB3 PIK3R5 MEMO1 APOE PCK1 GGA3 INS;INS-IGF2 FFAR1 GNAI2 RANBP9 DAGLA DGKB CHRM5 MLN GPRC6A RGS2 BDKRB2 BDKRB1 GAST PROK1 PRKCH DGKZ LTB4R2 DGKK RGS17 GRP LPAR1 LPAR2 LPAR3 LPAR4 PROKR1 P2RY2 P2RY1 TAC3 OPN4 NMB P2RY11 XCL1;XCL2 CCK LPAR5 NMS FFAR3;GPR42 F2RL2 GIP CDON ABCD3 NDUFS3 IGF1 PTGES3-1 MATK SFRP1 HGF DOCK7 GAB1 AREG FGF7 FGF22 TCF7L1 MYB CCL13;CCL2 CCL22 TSC2 CXCL8 CCL20 KDM1A ACKR4 CXCL5;CXCL6 CDC42 KLC2 FSHR RACGAP1 TSHR MFN1 GPHB5 CETP EEPD1 MFN2 SH2B3 KIF18A KIF2C IGF2 ATP6V1H RAB7A CFL1 TRIB1 MYH9 USP7 MAPKAP1 MDM2-2 PIN1 PRKAG3 MLST8 CASP2 SDR16C5 DHRS9 CRABP1 RDH14 PML LAMTOR2 TRRAP KDM1B RUVBL1 KDM3A RAMP2 KDM4B AR DSP FLT4 TMOD3 RARA TXNL1 SEMA4F NR3C1 TNFAIP1 LEMD3 RND3 CKAP4 KTN1 VANGL2 KCTD13 PKP4 ANKRD26;CCDC144A;LOC105375816 PICALM KIT CPNE8 WWC1 FCER2 PLXND1 PRAG1 FAM13B WIPF3 FAM13A ARHGDIG SYDE2 PREX2 GOLGA3 CSNK2B PREX1 ARHGAP42 CSNK2A1;CSNK2A3 BAIAP2L1 OPHN1 PRKCB MGLL FNBP1 EGFR TPM3 ACTN1 DYNC1I2 CYBB CYBA TEX2 BCR ALDH3A2 DAAM1 SPATA13 BTK BTRC STAM2 RHOBTB3 ARHGAP17 DYNC1H1 ARHGAP15 IQGAP2 IQGAP3 SKA1 SKA2 ARHGAP22 MYO6 STK38 PLXNA1 ABL2 NCKAP1L SRGAP2 MYH10 SRGAP1 RANBP10 SCAI MCAM ARPC4 PTK2 PLG DIAPH2 DIAPH3 NOXA1 NOX3 ACTR3-1 NF2 MAP3K11 ACTC1;ACTG2 CASP3 AHCTF1 RASGRF2 C1QBP MMP7 NUF2 CMA1 EFHD2 SPTAN1 MMP9 EMD GIT1 ADAM17 ARHGEF11 ACTR2 NUDC PLEKHG1 ARHGEF15 ATP6AP1 CCDC115 ARHGEF17 ARAP2 RHOF RHOD NIPSNAP2 SENP1 CDC42EP1 EVL PKN3 MEN1 WAS FAM169A CENPA NSL1 SH3BP1 SLITRK3 NHS EMC3 SLITRK5 STOM FLNA CSK HDAC1 RBBP6 WASF2 WASF3 CCNC-1 FARP1 USP9X CDC42BPA MYO9A CENPF H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ABI2 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI TAOK1 CENPM RAB9A PKN2 POLR2L GOPC B9D2 PKN1 HDAC5 SPTBN4 CBX4 GATAD2A SPTB CDK8 BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 TNF YY1 CDK5 CCL3L1;CCL3L3;CCL3;CCL18 SCD SHARPIN MIB2 EZH2 BIRC2 LAMA2 TNFRSF1A BIRC3 AXIN2 LAMB2 MEF2C S100A9 PSMD8 PSMA6 PSMD12 TAS2R3-1 PSMD11 TAS2R16 PRH1-TAS2R14;TAS2R14-3 PSMB1 CTNNB1 PSMC2-1 PSMA7 TAS2R40 TAS2R41 NPY CDKN2B CAMK4 MAPK14 TAS2R39 CSF2 AKT1 TAS2R7 TAS2R8 IFT140 IFT122 FUZ KIF7 TAS2R1 RBX1 PRKACB-1 TAS2R4 IFT52 ITCH SMO PRKAR1A PRKAR2A SMAD4 DAB2IP RASAL3 IL2 TAS1R1 SPRED3 TAS1R3 SPRED2 SPRED1 RASA4;RASA4B TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 NF1 NUP107 PLAT CAMK2B CAMK2D CAMK2A NUP85 CAMK2G PTPN7 POLR2G SEC13 PTPRJ NUP133 ZRANB1 GTF2F1 FGB FGA FGG F2 AP2A1 AP2A2 RIT2 THBS2 HTR6 FRAT2 HTR1A PPP2R5E TAAR5 PPP2R5B PPP2R5A PPP2R5D SCT PPP2R5C RXFP1 CDC37 ERBIN RGS8 GPR37L1 KEL PHB CENPS-CORT;CORT;CENPS TAS2R42 GIPR GPR83 NPBWR1 GALR1 JAG1 NPBWR2 TCIRG1 GRK6 WNT10B OPN3 GDNF PPP1R1B PNOC GPSM1 GPR20 GPER1 ID4 GRM8 ATP6V0D2 GPSM3 ALK ATP6V1A PTGIR GPR35 IRS1 MDK GLP2R FRS2 RAMP3 PIK3R1 PTGER2 TNRC6A-1 PTGER3 WNT8A CCL4L2;CCL4L1;CCL4 S1PR3 ATP6V0A4 RGS22 S1PR2 P2RY13 GPR55 WNT7A APLN ATP6V1F PDE7B ACKR1 RAMP1 TBK1 AKT2 AKT3 GNAZ JAK1 CYSLTR1 RIPK2 OPN1SW MYD88 GOLGA7-1 TYK2 ARRB1 IL2RB PIK3R4 PTPN2 CSF2RA IRAK1 ST3GAL4 IRS2 PRICKLE1 PPP3CB GNAT2 PDE6B PDE6A ST3GAL3 WNT5B FZD4 FZD7 WNT5A FZD6 PTPN11 CAB39 RPS27 ZDHHC9 RAG2 RAG1 TAB2 TEC ABHD17B RCE1 ABHD17C SPHK1 GNA14 CCNE1 GNB2 GNB1 GNB4 CCT7 NOTCH3 JUN EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma AREG EGFR GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense CASP1 GBP2;GBP3;GBP1 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination LAMA2 ADGRG6 MBP PMP22 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins NUP85 NPM1-2 RCC1 NUP88 SEC13 NUP133 NUP205 NUP107 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ10 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance ATRX TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PTK2 ITGAV PPP2R2A;PPP2R2D OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR14J1 OR10H1;OR10H5;OR10H2 OR4F21;OR4F16;OR4F29;OR4F3 OR7C1;OR7C2-9 OR8D1 OR6C76 OR5M10;OR5M1-1 OR5P2-4 OR10A4 OR4A47-3 OR10A5 OR2G6 OR51F1 OR2A7;LOC107987545;OR2A4 LHX2 OR4C11-1 OR12D3 OR8U8;OR8U1;OR8U9 OR2T12;OR2T33;OR2T8-1 LDB1 OR51E2 OR51M1 OR8I2 OR52W1 OR2T1 OR5V1-2 OR52D1 OR2AG1;OR2AG2 OR1I1 OR51B6 OR8H2;OR8H3;OR8H1 OR10K2 OR51I2 OR2T29;OR2T5-3 OR5P3 GNB1 OR51I1 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling CAMK2A PPP2R5D CAMK2G PDE1A PLCB4 PRKACB-1 PRKAR1A PRKAR2A CDK5 CAMKK2 MAPK1 PPP1R1B GNA14 PPP3CB AHCYL1 GNB2 CAMK4 GNB1 GNB4 GNAI2 CAMK2B CAMK2D CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation FBXL19 KLHL2 FBXL16 FBXL14 KLHL20 SPSB2 SPSB1 UBOX5 MKRN1 ASB7 BLMH TRIM37 RNF220 MIB2 SEC61A2 CD207 SEC22B LY96 TLR4 S100A9 FZR1 PSMD8 CDC34 UBE2C PSMA6 UBE2D3;UBE2D2 CDC26 ANAPC1 PSMD12 PSMD11 ANAPC10 CYBB ANAPC11 CYBA PSMB1 PSMC2-1 PSMA7 BTK BTRC MYD88 UBE2V1 RBX1 ITCH PIK3R4 S100A1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2D4 SEC13 FBXO21 DCAF1 ITGAV HERC2 TRIM21 UNKL FBXO7 FBXW8 KCTD7 RNF126 SEC31A FGB FBXW4 RNF138-1 FGA UBE2R2 RNF213-2 UBA6 RBBP6 RNF6 RCHY1 ASB16 ERAP1 FGG UBE2J1 FBXL20 HECTD1 UBA7 BTBD1 HECTD3 LONRF1 UBE2B KLHL25 RNF25 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD CSPG5 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling BTRC PSMD8 PSMA6 PSMD12 MAP3K14 PSMD11 PSMB1 PSMC2-1 PSMA7 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair ATR RAD9A POLD4 RFC1 MUS81 PARP2 EME1-1 EME2 PALB2 SLX1A;SLX1B H2BC15;H2BC3;H2BC11;H2BC12 EXO1 RFC5 RFC3 RFC4 RFC2 PCNA WRN RBBP8 RPA2 RPA3 PPP4C HERC2 POLQ RHNO1 POLH CCNA1 CLSPN RTEL1 BARD1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism PGM1 GALM-2 AKR1B1 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways AKT2 AKT3 AKT1 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination NTHL1 TERF2IP TDG TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME SLC28A2 SLC29A3 ADA NME1 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport CPTP TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment RIPK1 UBE2V1 UBE2D3;UBE2D2 BIRC2 BIRC3 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 BDNF PTPN11 FRS2 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System RBSN RHOA CAPZA1 CRK DOCK1 GSDME MYO10 MYO5A ITK NOS2 ATP6V1H RAB7A PKP1 CFL1 LY96 GSDMD RIPK1 TRAF2 TLR4 CDC34 UBE2D3;UBE2D2 MYH9 RAP1A MAP2K2;MAP2K1 FRK CTSH MAPK1 C3AR1 APOB ACTR10 ATG5 PIN1 MAP3K14 CASP2 LRRC7 GNS LAMTOR2 PLCG2 ITGAV TCN1 LGMN GPI PYGB PYGL ECSIT DSP PECAM1 SLC44A2 ASAH1 CKAP4 CPNE3 WIPF3 FABP5 CSNK2B CYBB CYBA SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 BTK BTRC ACLY DYNC1H1 IQGAP2 BIN2 NCKAP1L PSAP ARPC4 PTK2 SIRPB1 ACTR3-1 NF2 CASP3 CTSG HPSE C1QBP SPTAN1 MMP9 S100A1 ACTR2 PRSS3;PRSS2;PRSS1 ITGAM TASL IRF5 LY86 KLKB1 PGM2 RHOF UNC93B1 PGM1 WAS STOM WASF2 WASF3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ABI2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 CGAS RAB14 DYNLT1 AHCYL1 BIRC2 CHGA PGLYRP2 SERPINB1 BIRC3 DEFB129 DEFB127 S100A7A;S100A7 MEF2C ATOX1 ART1 MAP3K8 BPIFB2 BPIFA1 PDZD11 NLRP4 REG3G;REG3A-1 TREX1 RNASE7 RNASE3;RNASE2-2 S100A9 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 HSP90B1 PRKDC MAPK14 MGST1 NEU1 PRKACB-1 ITCH CTSA DERA CFD CFB PLAU SERPINB6-2 PAFAH1B2 RAB27A PTPRJ GAA AMPD3 OTUD5 CRP FGB COLEC10 FGA AGL-1 F12 HEXB FGG POLR3A F2 POLR3D POLR3F UBA7 POLR3K DDX58 MUC5B CFP AP2A2 MUC1 PPP2R5D MUC4 MUC21 ATP8A1 TCIRG1 ATP11B ATP6V0D2 ATP6V1A PIK3R1 ATP6V0A4 IDH1 ATP6V1F ABCA13 MAGT1 HP;HPR MAN2B1 TBK1 PA2G4 TOLLIP C1QB CPB2 PLEKHO2 CR2 C7 SERPINB10 CD3G C1R C9 RIPK2 C1QC CPN1 CARD9 USP14 NKIRAS1 SLCO4C1 NKIRAS2 ANO6 PELI1 RAB3D LAMP1 GOLGA7-1 MYD88 PKM LAMP2 ILF2 RAB37 TLR7 CLEC4E RAB5C UBE2V1 ARL8A PTPRB MASP1 SNAP29 CANT1 PRCP CPPED1 FTH1 PIK3R4 NOD1 ANPEP IRAK1 DHX58 PDXK SLPI CRISPLD2 TXK DHX36 PPP3CB VAT1 SIGLEC15 CNPY3 PRG3 ORM2;ORM1 PTPN11 CD63 CAB39 ENPP4 PYCARD IRAG2 P2RX7 DPP7 TAB2 AIM2 CASP1 SUGT1 MS4A2 TRIM21 TEC JUN CDC42 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism GDPD1 GDPD5 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism SLC37A4 PPP1R3C NHLRC1 GAA TALDO1 G6PC1 GNS FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT4 KDR GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism NEU3 ARSJ NEU1 PSAP ARSH ARSI HEXB SMPD1 ASAH1 CTSA M6PR NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPL35 RPL38 RPL39 RPL22 GSPT1 RPL18 ETF1 RPL29 RPL7A SMG5 SMG6 RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 PPP2R2A;PPP2R2D RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 SNW1 PSEN2 PSMD8 RBX1 PSMA6 MAMLD1 FLT4 APH1A PSMD12 PSMD11 PSENEN PSMB1 JAG1 PSMC2-1 PSMA7 HES5 AKT1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine NTHL1 TERF2IP TDG TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPL35 RPL38 RPL39 RPL22 RPL18 EIF3C;EIF3CL EIF3L EIF2S2 EIF3E EIF2S3;EIF2S3B RPL29 EIF3B RPL7A RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 EIF4E EIF4B RPL6 RPL7 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage GSDMD CASP3 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling ARRB1 TGFB2 TGFBR1-1 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism FADS2 HSD17B4 ELOVL5 ELOVL1 FADS1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSEN2 APH1A PSENEN JAG1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling JAK1 UBE2D3;UBE2D2 TYK2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) CILP PIK3R4 IGF1 FLT3 KLB GAB1 IRS2 AKT2 FGF7 TRIB3 IGF2 FGF22 FGF19 PDE3B IRS1 PTPN11 FRS2 PIK3R1 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins F10 F2 F9 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors MEF2C GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism SLC9A1 NDST3 ST3GAL6 SDC3 ACAN GLCE CHST2 B4GALT6 HAS3 ST3GAL4 HPSE GPC3 SLC35B3 GPC2 GPC4 ST3GAL1 ST3GAL3 CHSY3 HS6ST2 GNS HS3ST2 CHP1 FAM20B B3GNT2 HEXB HYAL3 SLC26A2 XYLT2 CSPG5 CEMIP SLC35D2 HMMR NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 CSK PTPRJ SH2B3 CBL FLT3 ABL2 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair PARG POLB PARP2 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity CDK6 PTPN11 TNRC6A-1 PML VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair RFC3 RFC4 RPA3 RFC2 POLB POLD4 PCNA RFC1 RPA2 RFC5 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex SNW1 TFDP1 PPP1R15A USP15 TFDP2 MEN1 PPP1CC ITGAV CBL CDK8 RHOA TGFB2 TGFBR1-1 STRAP MAPK1 SMAD4 HDAC1 CDKN2B CCNC-1 USP9X MTMR4 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis GGPS1 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs BCL11A HIP1 NPM1-2 STRN ALK PRKAR1A HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse MYH10 ARHGEF11 RHOA MYH9 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 CFB LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells STAM2 SH3KBP1 EPS15 CBL CTNNB1 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism RANBP9 RMND5B ME1 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane ARL6 PKD2 MCHR1 SMO BBS7 EXOC7 RAB11A RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance APOB APOE PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import CRAT IDH1 UBE2D3;UBE2D2 HACL1 GSTK1 DECR2 AMACR ZFAND6 PEX7 PIPOX HMGCL USP9X HSD17B4 NOS2 PEX12 PHYH-4 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT9 NPM1-2 BTG2 PLAGL1 CNOT6 CNOT7 CENPJ TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) SV2A TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation ATP6V1H AP2A1 AP2A2 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 HGF BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation GCH1 SPR AKT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes NCAPD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCNB1 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis HHAT PSMD8 PSMA6 ADAM17 PSMD12 PSMD11 SYVN1 PSMB1 PSMC2-1 PSMA7 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant JAG2 ADAM17 JAG1 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis POLA2 RFC3 RFC4 RPA3 RFC2 POLD4 PCNA RFC1 RPA2 RFC5 SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes EXOSC2 POLR2L EXOSC1 MPHOSPH6 RFC1 EXO1 BATF RFC5 RFC3 RFC4 RFC2 PCNA E2F7 E2F8 CTNNBL1 ELL TAF7L E2F2 POLR2G TAF12 NCOA6 TAF13 TAF11 SSRP1 CTR9 AFF4 GTF2F1 MAD2L2 POLH REV1 TAF7 MLLT3 TAF5 SUPT6H TAF2 MYB DIS3 APEX2 EXOSC6 EXOSC4 EXOSC9 EXOSC8 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis PPP1R3C PGM1 NHLRC1 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins NUP85 PSIP1 NUP88 SEC13 NUP133 NUP205 NUP107 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis FLI1 TFDP1 TFDP2 MYB GFI1 RARA H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KLF5 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation HEXB ACAN GNS EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle PSIP1 XRCC4 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle EDEM3 RNF103 RNF139 TRIM13 EDEM2 SYVN1 UGGT2 GANAB UGGT1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense CASP1 GBP2;GBP3;GBP1 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism PTGES3-1 GGT1 PON2 PON1 PTGDS PTGR2 LTC4S SLC27A1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DPEP1 CBR1-1 PON3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors RAMP2 RAMP1 RAMP3 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions FGB FGA COL18A1 FGG KDR ITGAV ITGAM PECAM1 COL4A4 ICAM5 FBN1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation C1QB C1R C1QC CRP PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO SENP1 SUMO1 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters SLC9A1 SLC31A1 SLC8B1 SLC40A1 SLC8A1 SLC30A3 SLC8A2 HEPH SLC30A2 SLC39A5 SLC9A2 SLC9A3 SLC9A4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR2L POLR3A POLR3D POLR3F GTF3C2 POLR3K G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK BTK GNB2 GNB1 GNB4 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion APOBEC1 APOBEC2 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle POLR2L TFDP1 B9D2 TFDP2 CNEP1R1 E2F3 PTK6 KIF18A H2BC15;H2BC3;H2BC11;H2BC12 KIF2C GOLGA2 POLA2 NCAPG PKMYT1 MAU2 NCAPD3 PSMD8 PSMA6 ATRX PSMD12 TERF2IP PSMD11 TERF2 GINS1 GINS2 CDC45 MCM8 PSMB1 PSMC2-1 RHNO1 PSMA7 MAPK1 MDM2-2 NPM1-2 PCBP4 CCNA1 CDKN2B RTEL1 BARD1 MAPK14 AKT1 ATR RAD9A MIS18A RSF1 RBX1 EXO1 ZNF385A RFC5 RFC3 LCMT1 RFC4 RFC2 PCNA CDK6 WRN RAB1B RBBP8 MYBL2 NUP205 RPA2 NUP107 NUP85 RPA3 E2F6 RCC1 NUP88 POLR2G SEC13 DKC1 NUP133 RUVBL2 NOP10 RUVBL1 PPP2R2A;PPP2R2D CHMP2B CHMP3 CLSPN CHMP6 SMC3 TYMS STAG2 SUN1 CDKN2D MLH3 CDKN2C REC8 SMC1B STAG3 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C POLD4 RFC1 SUMO1 LEMD3 WAPL CDK11A;CDK11B CSNK2B CSNK2A1;CSNK2A3 FZR1 UBE2C LPIN1 PRKCB CDKN2A CDC26 PPP1CC ANAPC1 ANAPC10 LIN52 DYNC1I2 ANAPC11 DCTN2 SSNA1 CEP164 CCNB2 ACTR1A CCNB1 TUBA1A AKT2 CEP250 AKT3 BTRC CDK5RAP2 CEP78 DYNC1H1 CEP135 ODF2 SKA1 CEP152 SKA2 HAUS4 CSNK1D HAUS5 TUBG1 HMMR NEDD1 NEK9 CENPJ NEK6 ALMS1 CEP63 STN1 DSCC1 AJUBA TUBGCP5 TUBGCP6 AHCTF1 TUBGCP4 NUF2 EMD NUDC FOXM1 COP1 PHF20 RPS27 LBR E2F2 PHLDA1 HERC2 CENPA NSL1 TUBB2B;TUBB2A TUBAL3 HDAC1 GMNN ORC1 ANKRD28 CCNE1 ORC2 PPP6C GORASP1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CENPF PIF1 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CENPI TAOK1 CENPM DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants JAG2 MIB2 ADAM17 JAG1 MIB1 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle PKN2 RACGAP1 LBR PREX1 PKN1 MCAM ERBIN OPHN1 PKN3 DIAPH3 RHOA BCR DAAM1 STOM ABCD3 C1QBP ARHGEF11 IQGAP3 PIK3R1 ARHGEF17 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP PLG APOE IGF1 CKAP4 KTN1 CTSG GPC3 MMP1 CALU IGF2 LAMB2 MBTPS1 BPIFB2 FBN1 CDH2 APOA2 MEN1 APOA1 MGAT4A-1 PRSS23 FGA IGFBP6 APOB CCN1 IGFBP5 IGFBP4 MXRA8 HSP90B1 FGG VWA1 F2 FAM20A MSLN DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina CNEP1R1 LPIN1 EMD PRKCB LEMD3 CCNB1 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics CYP2D6;LOC107987479;LOC107987478-1 ARNT2 CYP2S1 ARNT H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD BCKDHB PPM1K NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus PSEN2 APH1A PSENEN BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHA DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) SC5D ELOVL6 SCD FASN ACACB GGPS1 MTF1 TGS1 NCOA6 MBTPS1 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome MAPK1 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors PRKACB-1 PFKFB1 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis MAPK1 CTSG RNF213-2 SFPQ-1 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein SUMO1 SRPK1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) PARP2 RBBP8 POLQ TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer TGFBR1-1 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair RPA3 ATR RAD9A PALB2 EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 WRN BARD1 NTHL1 RBBP8 RPA2 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion DAD1 RPN2 CDH8 RPN1 H2BC15;H2BC3;H2BC11;H2BC12 ZC3H12A GANAB CDH19 CDH24 EPS15 MPHOSPH8 FOXA2 EZH2 TNRC6A-1 CDH11 CSNK2B TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PSMA7 MAPK1 STRAP MDM2-2 HDAC1 ZMYM2 BANP SNAI1 MCRIP1 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ZBTB33 RBBP7 FOXP2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PKM ILF3 KLF9 HOXC8 CTBP1 TMEM258 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation SPHK1 AHCYL1 PRKCB KDR SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 MAPK1 CSNK2B CSNK2A1;CSNK2A3 L1CAM ITGAV EGFR MAP2K2;MAP2K1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35B3 SLC35D2 SLC35A1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance APOC1 APOB APOA1 APOBR APOE AP2A1 AP2A2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG DAGLA MGLL METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A9 S100A7A;S100A7 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism MAN2B1 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions CYP2D6;LOC107987479;LOC107987478-1 CYP2S1 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis NEU3 DHDDS NEU1 ST3GAL6 ST6GALNAC3 NUDT14 CTSA SLC35A1 FCSK DOLPP1 NAGK GMPPA ST3GAL4 ST6GALNAC5 AMDHD2 GFPT1 RENBP GNE ST6GAL1 ST3GAL1 ST3GAL3 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling FGF19 PTPN11 FRS2 KLB P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB RIPK2 MYD88 IRAK1 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases POLR2L SH2B3 PTK6 CBL RHOA CDK5 CRK DOCK1 ESRP1 HNRNPA1-1 IGF2 EPS15 AHCYL1 LAMA2 PDE3B ATP6V1H LAMB2 FGFRL1 MEF2C BDNF TRIB1 FLT3 CTNNB1 RAP1A MAP2K2;MAP2K1 MAPKAP1 MAPK1 TRIB3 MAPK14 GABRB3 AKT1 MEMO1 PRKACB-1 APOE ITCH MLST8 SPRED2 SPRED1 TPH1 GGA3 PLAT INS;INS-IGF2 PSEN2 POLR2G APH1A PTPRJ ITGAV PSENEN GTF2F1 THBS4 AP2A1 AP2A2 THBS2 RIT2 PPP2R5D RANBP9 CDC37 ERBIN FLT4 TCIRG1 COL4A5 KIT ID4 ATP6V0D2 ATP6V1A ALK IRS1 MDK FRS2 COL4A4 PIK3R1 COL6A3 ATP6V0A4 PRKCB ATP6V1F EGFR CYBB CYBA KLB AKT2 AKT3 STAM2 EGR1 FGF19 NCKAP1L RANBP10 PTK2 PLG PIK3R4 IGF1 PTPN2 IRS2 CMA1 MMP9 ADAM17 ATP6AP1 PTPN11 MATK TAB2 KDR CILP GRAP TEC HGF DOCK7 GAB1 AREG CSK FGF7 SH3KBP1 SPHK1 HDAC1 FGF22 WASF2 WASF3 ABI2 CDC42 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET RANBP10 RANBP9 PTK2 PTPRJ CBL HGF PTPN2 DOCK7 RAP1A CRK GAB1 STAM2 SH3KBP1 EPS15 LAMA2 LAMB2 GGA3 PTPN11 PIK3R1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane PRNP EMD OTOF GET1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 COP1 PSMC2-1 PSMA7 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion UBAP1 MVB12A CHMP3 CHMP6 PDCD6IP TSG101 CHMP2B UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 WRN BARD1 RBBP8 PALB2 EXO1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA14 CA1 CA3 CA2 CA7 CA6 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2L POLR2G SSRP1 GTF2F1 ELL ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes RFC3 RFC4 MAD2L2 RFC2 REV1 POLH PCNA RFC1 EXO1 RFC5 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence MAP3K5 TFDP1 TFDP2 E2F3 CBX4 BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 CDK6 EZH2 TNRC6A-1 E2F2 CDKN2A MAPK1 MDM2-2 CDKN2B MINK1 MAPK14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MAP4K4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CDKN2D CDKN2C JUN INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription SNW1 HES5 MAMLD1 WWC1 PLXND1 NOTCH3 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria TFDP1 TFDP2 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1-1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TLR4 TAB2 LY96 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway PTK2 PRKACB-1 RHOA MLST8 CRK DOCK1 AHCYL1 PIK3R1 PRKCB KDR ITGAV CYBB CYBA CTNNB1 MAPKAP1 AKT2 AKT3 SPHK1 TRIB3 WASF2 WASF3 MAPK14 ABI2 AKT1 CDC42 NCKAP1L DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 ST3GAL3 ACAN COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation COL17A1 COL18A1 COL15A1 TMPRSS6 COL12A1 MMP20 MMP7 MMP1 MMP9 MMP10 MMP12 ADAM17 PRSS3;PRSS2;PRSS1 MMP19 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle PRKAG2 CPT1A UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin TXNRD1 CD9 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade PIK3R4 FLT3 KLB GAB1 IRS2 AKT2 FGF7 TRIB3 FGF22 FGF19 PDE3B IRS1 PTPN11 FRS2 PIK3R1 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPL35 RPL38 RPL39 RPL22 RPL18 EIF3C;EIF3CL EIF3L EIF3E RPL29 EIF3B RPL7A RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 RPL31 RPL6 RPL7 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade PPP2R5D TRAF2 UBE2V1 TAB2 NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC ECSIT RIPK2 USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MEF2C MYD88 MAP3K8 JUN CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 PPP2R5E PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA2 PPA1-1 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation POLR2L SNAPC1 SNAPC2 SSB POLR3A NFIB POLR3D POLR3F GTF3C2 POLR3K GTF3A BRF2 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants ZMYM2 FGFR1OP2 BCR PIK3R1 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing PABPN1-1 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways SNW1 HMG20B FASN HNRNPA1-1 DHX38 ATP6V1H HNRNPA2B1 LY96 RIPK1 SNRPA1 TLR4 MAPKAP1 NPM1-2 RPL4 RPL30 RPL31 PABPN1-1 EIF4E RPL6 RPL7 RPL35 RPL38 RPL39 RPL22 MLST8 MED8 RPL29 PML PLCG2 BRMS1 FKBP4 SUMO1 NR3C1 MED28-1 RPL18 PPIB CSNK2B CSNK2A1;CSNK2A3 EGFR PPP1CC DYNC1I2 RPL37A-1 BTK BTRC DYNC1H1 HNRNPR CLDN1 TYRO3 GRPEL1 KPNA4-1 PQBP1 ISY1;ISY1-RAB43 SF3B6 BRD4 XAB2 NUDT21 PHF5A MMP9 SNRPN LY6E BAG2 CHERP EIF4G3 RPL7A CTNNBL1 SIGMAR1 PSIP1 PUF60 MED16 MED17 DNAJA2 PPIL4 APOA1 SRRM2 IL1R1 COG1 SAP30 CTR9 MED23 MED24 SUGP1 GTF2H2C;GTF2H2C_2;GTF2H2 SH3KBP1 HDAC1 CCNC-1 PCF11 CHMP1A SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPRE3 TAOK1 PPIL1-1 POLR2L WBP11 PRPF6 PPIH GTF2H3 PPIG RTN3 PRPF8 GATAD2A CDK8 H2BC15;H2BC3;H2BC11;H2BC12 CGAS ELAVL2 GBP2;GBP3;GBP1 BLNK ERCC3 DYNLT1 BUD31 MED31-1 EZH2 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 PABPC1;PABPC3 AKT1 RBX1 NRBP1 ITCH SMAD4 NUP205 NUP107 TSG101 CAMK2B ELL CAMK2D TAF7L CAMK2A NUP85 MVB12A RCC1 CAMK2G NUP88 POLR2G SEC13 PDCD6IP NUP133 XRCC4 TAF12 TAF13 TAF11 SSRP1 GTF2F1 CHMP2B NMT1 UBAP1 CHMP3 TAF7 TAF5 CHMP6 TAF2 F2 UBA7 DDX58 AP2A1 AP2A2 IFIT3 VPS25 COMT ATP1B1 ATP1A1 PIK3R1 ATP1B3-1 FXYD2;FXYD6-FXYD2 MGAT4A-1 GEMIN2 MAGT1 ZDHHC3 RPS15 TBK1 AKT2 AKT3 RPS11 RPS13 JAK1 ST6GAL1 CYSLTR1 RIPK2 VPS33A VPS33B SFTPD ANO6 GOLGA7-1 TYK2 TUFM TMEM258 DAD1 TLR7 RAB5C UBE2V1 SNRPF MASP1 ST6GALNAC3 ISCU RPN2 SDC3 RPN1 PIK3R4 DDX20 AP1S3 NOD1 GANAB IRAK1 MGAT5 ST3GAL4 GPC3 PTGES3-1 VPS11 GPC2 SNRPE-2 GPC4 SNRPG-2 ST3GAL1 ST3GAL3 VPS16 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 PTPN11 MPP5 SRPK1 RPS25 RPS27 ZDHHC9 RPS29 PYCARD MGAT4B IL17F TAB2 FAU CASP1 STT3B RPS21 RPS24 IL17A UBA6 KDM1A PHF21A DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation TDGF1 DPPA4 POU5F1;POU5F1B NANOG;NANOGP8 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication POLD4 RFC1 RBX1 TWNK H2BC15;H2BC3;H2BC11;H2BC12 POLG2 RFC5 RFC3 POLA2 RFC4 RFC2 PCNA RPA2 RPA3 FZR1 PSMD8 UBE2C PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 GINS1 ANAPC11 GINS2 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 GMNN CCNA1 ORC1 ORC2 CCNE1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MGME1 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling CRLF1 JAK1 LIFR CBL PTPN11 TYK2 OSMR CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway PYCARD PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis INHBC BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization GRPEL1 TIMM21 PMPCB HACL1 GSTK1 DECR2 MTX2 EMD HMGCL NOS2 ATP5MC1 HSCB CRAT HSPA9 COA4 FIS1 CHCHD10-1 TIMM17A-1 TIMM17B IDH1 OTOF UBE2D3;UBE2D2 BCS1L AMACR SLC25A17 ZFAND6 PRNP PEX7 ABCD3 PIPOX VDAC1 NDUFB8 HSD17B4 USP9X GET1 PEX12 TOMM7 PHYH-4 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway SH3KBP1 RELN SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR1-1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome PYCARD AIM2 CASP1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor GRIK5 GRIK4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis PRKCH DGKZ DGKK DAGLA MGLL DGKB TRPC6 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis ST3GAL4 ST3GAL6 ST3GAL3 B3GALT2 B4GALNT2 FUT9 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins FGB FGA PTK2 FGG APBB1IP RAP1A LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism FADS2 ELOVL5 ELOVL1 FADS1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein GANAB RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes INTS7 POLR2L INTS11 INTS13 NABP2 SNAPC1 SNAPC2 POLR2G RPRD2 TAF13 TAF11 GTF2F1 TAF5 PCF11 INTS3 ELL INTS2 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism CTSH SFTPD P2RY2 ADRA2A CSF2RA CKAP4 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses LIN7C LRRTM1 SLITRK6 SHANK2 LRRC4B SYT9 DLGAP4 PPFIA4 PPFIA3 RTN3 PPFIA2 SYT2 SLITRK3 SLITRK5 SHARPIN NLGN3 NLGN4X;NLGN4Y HOMER1 NRXN3 PTPRD LRRTM3 SLITRK2 LRRTM4 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function MDM2-2 EPS15 PSMD8 PSMA6 BANP PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway RAB5C TLR7 RBX1 SDC3 CDK8 MED28-1 MED8 GPC3 GPC2 MED31-1 GPC4 LY96 CSNK2B MED16 MED17 CSNK2A1;CSNK2A3 TLR4 EGFR PPP1CC MED23 MED24 JAK1 CCNC-1 DDX58 TYK2 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type CSPG5 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion INS;INS-IGF2 KCNG2 PRKACB-1 KCNS3 FFAR1 ADRA2A PRKAR1A PRKAR2A RAP1A ACSL3 GNA14 KCNB1 AHCYL1 GNB2 AKAP5 GNB1 GNB4 GNAI2 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity MAPK1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery POLR2L POLR2G SSRP1 GTF2F1 ELL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation IARS1 GARS1 FARSA YARS1 TARS1 VARS1 PPA2 PPA1-1 AARS2 PARS2 AIMP1 YARS2 EARS2 WARS2 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling CAMK2A CAMK2G TRIM62 SUMO1 IRF6 TRIM21 IRF9 GBP7;GBP4 TRIM38 MT2A TRIM31 GBP2;GBP3;GBP1 MAPK1 TRIM8 JAK1 HLA-DPB1-1 HLA-DPA1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IRF5 PTPN11 CAMK2B CAMK2D PML ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones MBTPS1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification ANK2 SPTBN4 SPTB CAPZA1 B4GALT6 GOLGA2 MGAT5 ST3GAL4 ANK1 DCTN1 MAN1A1 SPTAN1 RAB1B MGAT3 SEC22B INS;INS-IGF2 TRAPPC4 MGAT4B TRAPPC10 SEC13 MIA2 TRAPPC6A DYNC1I2 TRAPPC6B DCTN2 MGAT4A-1 TMED7 TMED9 COG1 ACTR1A PREB SEC31A AREG KDELR2 COG8 COG6 ANKRD28 DYNC1H1 PPP6C ST6GAL1 COG2 BET1L SEC23IP GORASP1 ACTR10 LMAN2 CSNK1D SEC22C CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events CAMK2A CAMKK2 CAMK2G PDE1A PRKACB-1 CAMK4 PRKAR1A PRKAR2A CAMK2B CAMK2D CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants ALK LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy UBAP1 PLIN2 MVB12A CHMP3 CHMP6 TSG101 CHMP2B THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSJ ARSH ARSI CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism DMGDH ALDH7A1 CHDH SLC44A2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 FGF7 FGF22 PTPN11 FRS2 PIK3R1 GAB1 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC20A1 SLC20A2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation UBE2V1 TAB2 RIPK2 MAPK14 NOD1 IRAK1 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 SNW1 JAG2 PSEN2 MAMLD1 APH1A EGFR PSENEN JAG1 MIB2 HES5 WWC1 PLXND1 NOTCH3 MIB1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPL35 RPL38 RPL39 RPL22 RPL18 EIF2S2 EIF2S3;EIF2S3B RPL29 RPL7A RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 TRIB3 RPS13 RPL4 RPL30 RPL31 RPL6 RPL7 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events PPP1R1B PPP2R5D PPP3CB PRKACB-1 PRKAR1A PRKAR2A CDK5 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 PTPN11 HGF GAB1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes P2RX7 CACNA1H ITGAV AKT1 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling LAMTOR2 STRADA CAB39L PRKAG3 MLST8 PRKAG2 AKT2 AKT1S1 AKT3 EIF4EBP1 TSC2 EIF4E EIF4B TNRC6A-1 AKT1 CAB39 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMKK2 CAMK2G CAMK4 CAMK2B AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling AREG EGFR DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization CATSPER4 CD9 ZP3;POMZP3 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT1 LTC4S CYP4F3;CYP4F2;CYP4F12;CYP4F11 DPEP1 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex PHF10 PBRM1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland AREG MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease EXOSC2 EXOSC1 DIS3 EXOSC6 EXOSC4 EXOSC9 EXOSC8 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNB1 CCNA1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events MAPK1 FRS2 RAP1A CRK MAP2K2;MAP2K1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism MPST CDO1 ETHE1 AHCY GADL1 MTR-1 ENOPH1 CBS;CBSL SLC25A10 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle MFN1 MFN2 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense UBE2D3;UBE2D2 GBP2;GBP3;GBP1 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition TFDP1 TFDP2 PTK6 POLA2 PCNA RPA2 RPA3 E2F6 PSMD8 PSMA6 PSMD12 PSMD11 LIN52 CDC45 MCM8 PSMB1 PSMC2-1 PSMA7 CCNB1 AKT2 AKT3 HDAC1 GMNN CCNA1 ORC1 ORC2 CCNE1 TYMS AKT1 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) SC5D ELOVL6 SCD FASN ACACB GGPS1 MTF1 TGS1 NCOA6 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 PPP2R5E SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1-1 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance APOC1 APOB APOBR MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase NUP85 NCAPD3 NUP88 CNEP1R1 LPIN1 SEC13 PRKCB NUP133 H2BC15;H2BC3;H2BC11;H2BC12 LEMD3 CCNB2 GOLGA2 CCNB1 MAPK1 EMD RAB1B GORASP1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP205 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP107 NEK9 NEK6 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes TFDP1 CNOT9 TFDP2 BTG2 ZNF385A CCNB1 NPM1-2 PCBP4 PCNA CCNA1 CCNE1 PLAGL1 E2F7 E2F8 CNOT6 CNOT7 CENPJ CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC1 ORC2 MCM8 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 COX7C COX6C BACH1 TGS1 PTK6 NCOA6 HM13 STAP2 COX6A1 COX6A2 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function CDH24 SNAI1 CDH8 ILF3 CTNNB1 TNRC6A-1 HOXC8 CDH11 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity PPP2R5C GATAD2A CDK5 CSNK2B CSNK2A1;CSNK2A3 TP53RK USP7 RHNO1 MEAF6 MAPKAP1 AKT2 MDM2-2 AKT3 CCNA1 BANP BARD1 MAPK14 AKT1 JMY PIN1 ATR PIP4K2C RAD9A DYRK2 SETD9 PRKAG3 ING5 ING2 EXO1 MLST8 ZNF385A RFC5 RFC3 RFC4 RFC2 WRN RBBP8 RFFL RPA2 HIPK1 POU4F1 PHF20 PML TAF7L TTC5 RPA3 TAF12 TAF13 TAF11 SSRP1 PRKAG2 HDAC1 TAF7 TAF5 TAF2 RBBP7 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion KCNG2 KCNB1 PRKACB-1 KCNS3 GNB2 AKAP5 GNB1 PRKAR1A PRKAR2A GNB4 RAP1A PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination UBE2C CDC34 UBE2D3;UBE2D2 H2BC15;H2BC3;H2BC11;H2BC12 USP7 CTR9 UBE2R2 UBE2T UBA6 OTULIN PCNA USP9X PRKDC PEX12 RNF40 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RNF144A TMEM129 UBE2B RNF152 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells PRKCB CSF2 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis RIPK1 TRAF2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells LAMA2 LAMB2 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing NUP205 NUP107 NUP85 NUP88 SEC13 POP7 PUS3 POP1 NUP133 CTU2 POP4 TRMT10A RPP40 TRMT6 RTCB TPRKB TP53RK RPP21 TRMT13 C2orf49 C9orf64 RPP14 TRMT10C TRMT61A PRORP RTRAF ADAT3 YRDC MTO1 TRMT61B TRMT112 HSD17B10 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly PRKACB-1 APOA1 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis TMLHE NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response RPS27 RPS29 FAU RPS21 RPS24 IFIT3 RPS15 EIF3C;EIF3CL RPS11 EIF3L RPS13 EIF3E EIF3B RPS25 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling PPP2R5B PPP2R5A PPP2R5D PIP4K2C PPP2R5C IRAK1 IRS2 KIT PIK3CG IRS1 FRS2 PTPN11 PIK3R1 INS;INS-IGF2 BDNF EGFR FLT3 HGF KLB GAB1 AREG MAPK1 IER3 FGF7 IL33 FGF22 FGF19 STRN MYD88 PIK3R5 AKT1 PPP2R5E TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A RABGGTA BCL2L14 PRELID3A PERP CASP1 PIDD1 PRELID1 CRADD CASP2 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism GPC3 GPC2 GPC4 HEXB SDC3 ST3GAL3 ACAN SLC26A2 CSPG5 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters SLC5A1-1 LMBRD1 SLC29A3 ERLIN1 ERLIN2 SLC6A5 SLC6A2 SLC40A1 SLC17A8 SLC35A1 HEPH NUP205 NUP107 NUP85 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NUP88 PSMD8 SEC13 PSMA6 APOA1 SLC7A7 PSMD12 SLC12A6 NUP133 GCK PSMD11 PSMB1 PSMC2-1 PSMA7 SLC22A12 SLC22A18 SLC26A2 AVPR1B SLC20A2 ABCB6 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ PSAP PLG LGALS3BP PECAM1 WDR1 IGF1 OLA1 LEFTY2;LEFTY1 SYTL4 NHLRC2 ENDOD1 CLEC3B APOH MANF CALU IGF2 CYB5R1 CD9 SELP CFD ORM2;ORM1 CD63 CFL1 PRKCB APOA1 ACTN1 TGFB2 HGF FGB FLNA FGA FGG TTN-1 LAMP2 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling RHOA TNF CASP2 IRAK1 CASP3 RASGRF2 SPPL2B SPPL2A OTULIN SHARPIN NSMAF MIB2 BIRC2 ARHGEF11 TNFRSF1A ADAM17 BIRC3 ARHGEF15 ARHGEF17 FAS RIPK1 PREX1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PSEN2 TAB2 UBE2D3;UBE2D2 APH1A BEX3 PSENEN TBK1 HDAC1 RIPK2 MYD88 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication POLA2 TFDP1 TFDP2 ORC1 ORC2 MCM8 CCNB1 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression ARNT2 TXNRD1 MTF1 THRAP3 CDK8 ESRRA MED28-1 MED8 MED31-1 FHL2 TGS1 ME1 MED16 MED17 SLC27A1 APOA2 CPT1A APOA1 ARNT NCOA6 FADS1 MED23 MED24 PLIN2 TRIB3 CCNC-1 CYP7A1 PPARGC1B FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors FFAR3;GPR42 FFAR1 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function WRN BARD1 RBBP8 PALB2 EXO1 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle PKP4 ANKRD26;CCDC144A;LOC105375816 DSP TXNL1 PTPN13 LEMD3 FRS2 PLXNA1 PIK3R1 ALDH3A2 VANGL2 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome AREG CSK EGFR PTPN11 PIK3R1 GAB1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication DAD1 DNAJA2 KPNA4-1 RTN3 SUMO1 RPN2 APOA1 STT3B RPN1 MAGT1 NMT1 FASN PABPC1;PABPC3 BAG2 EIF4G3 EIF4E TMEM258 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2R2 UBE2T UBA6 OTULIN CDC34 UBE2C UBE2D3;UBE2D2 USP9X USP7 UBE2B INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling IRS2 RAG2 RAG1 JAK1 IL7R IRS1 CRLF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 HGF PIK3R1 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants FLT3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis DCT NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation ATP6V1H AP2A1 AP2A2 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint CCNA1 CCNB2 CCNB1 PKMYT1 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling UBE2V1 PLCG2 PSMD8 CDC34 EVL TAB2 UBE2D3;UBE2D2 PSMA6 WAS PTPRJ PSMD12 PSMD11 PTPN22 PSMB1 PSMC2-1 PSMA7 CSK BTRC CD3G ITK HLA-DPB1-1 RIPK2 HLA-DPA1 PIK3R1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis POLR2L NUP85 NUP88 POLR2G SEC13 NUP133 NUP205 NUP107 GTF2F1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate CRYL1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 TFDP1 E2F2 TFDP2 CDKN2B CDK6 E2F3 CCNE1 CDKN2A PTK6 CDKN2D CDKN2C PPP2R2A;PPP2R2D SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases EPAS1 PTK6 EGFR NR3C1 CBL RHOA DOK1 SFPQ-1 STAP2 CRK DOCK1 CCNE1 AKT1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template RPA3 USP10 POLD4 RFC1 RFC5 RFC3 RFC4 RFC2 MAD2L2 REV1 POLH PCNA RCHY1 UBA7 RPA2 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis NUP85 PPP2R5D NUP88 SEC13 PRKACB-1 NUP133 GCK GPI PFKP PFKFB2 GAPDH-1 PFKFB1 PFKFB4 ENO1 PFKFB3 ENO2 NUP205 NUP107 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC TUBA1A TUBB2B;TUBB2A TUBAL3 CCT7 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures PLEC COL18A1 COL15A1 MMP20 MMP7 COL4A5 MMP9 ITGB4 BMP1 LOXL3 LOXL1 COL4A4 PXDN TLL1 COL6A3 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 TBK1 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels STIM1 P2RX4 ORAI2 P2RX7 TRPC6 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors P2RY11 P2RY13 LPAR4 P2RY2 P2RY1 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste TAS2R1 TAS2R4 TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 TAS1R1 SCNN1G TAS1R3 SCNN1D SCNN1B TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GNB1 OTOP1 TAS2R39 CALHM1 TAS2R7 TRPM4 TAS2R8 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant JAG2 ADAM17 JAG1 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type MMAB DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis NEU1 CTSA MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling LAMA2 PTK2 LAMB2 HGF REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand RPA3 POLD4 PCNA WRN TERF2IP TERF2 RPA2 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling GIT1 EPHB1 EPHB4 EPHB3 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling JAK1 CBL PTPN11 TYK2 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL MAPK1 SMAD4 TDGF1 NODAL ACVR1B DAND5 CER1 LEFTY2;LEFTY1 GDF1 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism NUP85 NUP88 KPNA4-1 SEC13 NUP133 JAK1 UBA7 EIF4G3 EIF4E DDX58 NUP205 NUP107 PIN1 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions MTF1 MT2A PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) MAPK1 GNA14 ARRB1 F2RL2 GNB2 F2 GNB1 GNB4 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling MAPK1 CAPZA1 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ACAN INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling IL2 JAK1 IL2RB IL21R IL21 IL15 CSF2 PIK3R1 CSF2RA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC7A7 SLC7A8 SLC7A11 SLC38A3 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine NTHL1 TERF2IP TDG TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t PGM1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters SLC22A12 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE RASGRF2 PREX1 PSEN2 ARHGEF11 APH1A BEX3 PSENEN ARHGEF15 CASP2 CASP3 ARHGEF17 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 RIPK1 NKIRAS1 NKIRAS2 MYD88 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLAAT3 PLA2G3 LPCAT4 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly NUP85 LBR RCC1 SEC13 SUMO1 NUP133 LEMD3 CCNB2 AHCTF1 CCNB1 CHMP2B PPP2R2A;PPP2R2D TUBA1A TUBB2B;TUBB2A TUBAL3 CHMP3 CHMP6 EMD NUP205 NUP107 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family MUC1 CLEC4E PLCG2 MUC4 MUC21 MUC5B ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 FGF7 FGF22 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease FRS2 PIK3R1 GAB1 GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins LIN7C LRRTM1 SHANK2 SYT9 DLGAP4 SYT2 SHARPIN NLGN3 NLGN4X;NLGN4Y HOMER1 NRXN3 LRRTM3 LRRTM4 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation COLEC10 MASP1 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) CTNNB1 CDC42 CDH11 DOCK1 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IRS2 PIK3CG PIK3R1 PIK3R5 GAB1 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis ARPC4 PTK2 WAS ACTR3-1 MYH9 CRK DOCK1 MAPK1 BTK WASF2 MYO10 CD3G WASF3 MYO5A ACTR2 ABI2 WIPF3 CDC42 NCKAP1L DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function BARD1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification PRSS41 FBXL19 OTOA KLHL2 FBXL16 XPNPEP2 RTN4RL1 FBXL14 ST3GAL6 LY6D KLHL20 PIGK SPSB2 LY6G6C SPSB1 EPAS1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 PIGG ASB7 TECTA;TBCEL-TECTA GPLD1 RHOA CAPZA1 GOLGA2 GALNT14 GALNT9;GALNT17 GALNT16 GALNT15 GCNT1 GALNT10 POFUT2 GALNT9 B3GNT6 POMK SEC22B RAB7A RIPK1 TRAF2 CDC34 UBE2D3;UBE2D2 NUDT14 TGFBR1-1 USP7 RNF146 FCSK DOLPP1 GMPPA MDM2-2 COG8 NPM1-2 GNE APOB COG6 CCNA1 RAB36 COG2 BARD1 BET1L ACTR10 VDAC3 ING2 ANK1 OTULIN RABGGTA PCNA MAN1A1 WRN RAB11A PML USP10 USP15 TRRAP KDM1B DCAF13 TMED7 TMED9 RUVBL1 PREB KDELR2 METTL22 KIN FAM86B1;EEF2KMT;FAM86B2 EEF1AKMT2 HIF3A EEF1AKMT1 SMC3 STAG2 PSMD10 NRIP1 PSMD9 USP22 POMP USP37 COPS7B WDR20 XPC USP24 COPS7A USP25 AR USP20 PIAS3 USP44 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 SUMO1 VDR RAD23A USP28 PTRH2 RARA RAD23B DDB1 NR3C1 COPS8 CKAP4 KTN1 ETF1 CALU DCUN1D3 DDA1 ANKRD9 NAE1 DCAF10 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD4 NEURL2 CCDC22 OBSL1 EDEM3 MIA2 RNF103 DYNC1I2 RNF139 TRIM13 DCTN2 SYVN1 AGBL5 TTLL6 UGGT2 TTLL5 UGGT1 ACTR1A AGTPBP1 AGBL1 TUBA1A VASH2 VASH1 BTRC STAM2 IL33 DYNC1H1 CSNK1D CTBP1 ADAMTS1 SPTAN1 LY6E SENP1 APOA2 MEN1 APOA1 ALG8 ALG3 HCFC1 COG1 CTR9 SEC31A ST6GALNAC5 PRSS23 CCN1 HDAC1 IGFBP5 IGFBP4 ANKRD28 MXRA8 PPP6C VWA1 USP9X SEC23IP FAM20A GORASP1 LMAN2 TDG SEC22C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 RAB9A ANK2 DHDDS MCRS1 RAB2B RAB25 SPTBN4 RAB17 CBX4 SATB1 SPTB BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 RAB14 YY1 FOLR2 NAGK AMDHD2 GFPT1 RENBP DCTN1 BIRC2 BIRC3 AXIN2 LAMB2 MGAT3 BPIFB2 FBN1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 SATB2 PSMA7 VDAC1 PCGF2 HSP90B1 PRKDC PEX12 RNF40 RNF144A TMEM129 RNF152 NEU3 ARSJ NEU1 ARSH ARSI RBX1 APOE B4GALNT2 CTSA SLC35A1 SLC35A4 FKRP CRPPA LARGE2 SMAD4 FKTN RAB1B NUP205 NUP107 NUP85 INS;INS-IGF2 TRAPPC4 NUP88 TRAPPC10 RAB27A SEC13 RAB11B NUP133 TRAPPC6A XRCC4 TRAPPC6B RAB13 OTUD5 RAB38 ZRANB1 OTUB1 B3GNT2 FGA MITF F10 CLSPN FGG F2 F9 SEMA5A DDX58 MUC5B CFP THBS2 THSD4 ADAMTS10 ADAMTS20 MUC1 ADAMTSL5 THSD7A MUC4 MUC21 PALB2 UBE2C MGAT4A-1 MAGT1 DRG1 DPH5 DPH6 ZC3H15 ST6GAL1 RIPK2 USP14 RAB3D TMEM258 RAB37 DAD1 RAB5C POLB ARRB1 ST6GALNAC3 RPN2 RPN1 NOD1 B4GALT6 GANAB MGAT5 ST3GAL4 TOP2B GPC3 SMC6 NOP58 NSMCE1 NSMCE4A ST3GAL1 ST3GAL3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 COP1 MBTPS1 CDH2 MGAT4B FBXO21 STT3B HERC2 FBXO7 FBXW8 KCTD7 RCE1 AREG FBXW4 TUBB2B;TUBB2A UBE2R2 UBE2T UBA6 ASB16 LIPT1 PIGS FBXL20 TECTB NRN1 BTBD1 RTN4RL2 IZUMO1R UBE2B MSLN KLHL25 ALPG;ALPP;ALPI-1 PIGV REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation AKT2 AKT3 HDAC1 PIP4K2C ING5 GATAD2A ING2 RBBP7 AKT1 MEAF6 PIN1 PML CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway FAS RIPK1 TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TLR4 DCC CASP3 LY96 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS IRS2 PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair MSRA DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation CAMK2A PPP2R5B PPP2R5A PPP2R5D PPP2R5C CAMK2G PHB PPP1CC MRAS MAP3K11 MAP2K2;MAP2K1 CAMK2B CAMK2D PPP2R5E SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors APOB S100A9 APOA1 CD5L SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors APOB ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding CD9 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders LMBRD1 PSMD8 PSMA6 ERLIN1 APOA1 ERLIN2 PSMD12 PSMD11 PSMB1 ABCB6 PSMC2-1 PSMA7 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) FGB FGA BTK TLR4 S100A9 S100A1 FGG MYD88 LY96 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane PPP2R5D UBE2V1 NOD1 IRAK1 S100A1 MEF2C MAP3K8 LY96 TRAF2 TLR4 S100A9 TAB2 MAP2K2;MAP2K1 MAPK1 FGB FGA BTK BTRC ECSIT RIPK2 FGG USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes SERPINB13 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer SNW1 MAPK1 SMAD4 TFDP1 TFDP2 HDAC1 CDKN2B CCNC-1 USP9X MEN1 CDK8 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation CASTOR2 RPL35 RPL38 SZT2 RPL39 SH3BP4 MLST8 RPL22 BMT2 TCIRG1 RPL18 EIF2S2 EIF2S3;EIF2S3B RPL29 ATP6V0D2 ATP6V1A RPL7A ATP6V1H RPS25 RPS27 RPS29 LAMTOR2 SEC13 FAU ATP6V1F RPS21 RPS24 RPL37A-1 RPS15 NPRL2 WDR59 RPS11 TRIB3 RPS13 RPL4 RPL30 RPL31 DEPDC5 RPL6 RPL7 CASTOR1 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling PPP2R5D UBE2V1 IL17F TAB2 IL17A NOD1 IRAK1 MAP2K2;MAP2K1 MAPK1 BTRC RIPK2 MAPK14 IL25 MEF2C MAP3K8 JUN DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination USP37 WDR20 USP24 USP25 MCRS1 AR USP20 USP44 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RAD23A USP28 RAD23B PTRH2 RHOA H2BC15;H2BC3;H2BC11;H2BC12 YY1 BIRC2 BIRC3 AXIN2 RIPK1 TRAF2 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 TGFBR1-1 USP7 PSMC2-1 RNF146 PSMA7 MDM2-2 VDAC1 STAM2 IL33 CCNA1 RIPK2 BARD1 USP14 VDAC3 POLB ARRB1 NOD1 SMAD4 USP10 USP15 TRRAP KDM1B OTUD5 RUVBL1 HCFC1 ZRANB1 OTUB1 RCE1 CLSPN USP9X H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 DDX58 USP22 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 FZR1 UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events CAMK2A CAMK2G PDE1A PLCB4 PRKACB-1 PRKAR1A PRKAR2A CAMKK2 MAPK1 GNA14 AHCYL1 CAMK4 GNAI2 CAMK2B CAMK2D TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC2 EXOSC1 DIS3 EXOSC6 ZFP36 EXOSC4 EXOSC9 EXOSC8 DCP2-1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction CACNA1I MYL6B CACNA1H MYL7 TPM3 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling POLR2L PTK2 H2BC15;H2BC3;H2BC11;H2BC12 YY1 PTGES3-1 MMP7 CAV2 MMP9 PIK3R1 TNRC6A-1 S1PR3 POLR2G EGFR PPID GTF2F1 AREG MAPK1 AKT2 AKT3 HDAC1 SPHK1 MYB GNB2 STRN KDM1A SMC3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GNB1 KDM4B STAG2 NRIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNB4 GNAI2 TFF1 AKT1 FKBP4 JUN MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 PTPN11 FRS2 PIK3R1 GAB1 GSD II%REACTOME%R-HSA-5357609.5 GSD II GAA TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism AFMID IDO2 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus NUP85 NUP88 SEC13 NUP133 NUP205 NUP107 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants FGB MAPK1 FGA CSK ARRB1 FGG APBB1IP RAP1A MAP2K2;MAP2K1 KSR2 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling ARNT2 PTGES3-1 ARNT RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination NUDT21 SNRPF SNRPE-2 PCF11 SNRPG-2 PABPN1-1 ZNF473 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels TSC22D3 SLC9B2 SCNN1G SCNN1D SCNN1B TTYH2 TRPC6 TRPV6 CLCN3 TRPV4 CLCN2 TRPM8 CLCN1 TRPM4 ASIC4 BSND CLCA1 SGK3;C8orf44-SGK3 ASIC2 ASIC3 TPCN2 TPCN1 CLCN7 STOM CLCN6 CLCN5 CLCN4 ANO6 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions SEMA7A PLXND1 SEMA5A PLXNA2 PLXNB3 PLXNA1 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TDG CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) NQO1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) RHOA ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle LIN7C TSPOAP1 RIMS1 PPFIA4 SLC18A3 CPLX1 PPFIA3 GLS2 PPFIA2 MAOA ALDH5A1 GLS RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 UBTF GTF2H3 TAF1D RRN3 GATAD2A RBBP7 ERCC3 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion NGRN HSD17B10 TRMT10C PRORP ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide CA1 CA2 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling BEX3 CASP2 CASP3 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants FLT3 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair POLR2L COPS7B XPC COPS7A MCRS1 POLD4 PIAS3 RFC1 GTF2H3 MUS81 SUMO1 PARP2 RAD23A EME1-1 EME2 RAD23B DDB1 PALB2 SLX1A;SLX1B H2BC15;H2BC3;H2BC11;H2BC12 COPS8 YY1 EYA1 EYA3 ERCC3 APBB1 DCLRE1C NTHL1 TDP2 POLL NHEJ1 PSMD8 PSMA6 TERF2IP PSMD12 TERF2 PSMD11 PPP4C PSMB1 USP7 ASCC2 PSMC2-1 RHNO1 PSMA7 MAD2L2 POLH REV1 CCNA1 RTEL1 BARD1 PRKDC FANCI FANCC PARG ATR POLB RAD9A RBX1 EXO1 ISY1;ISY1-RAB43 RFC5 RFC3 RFC4 XAB2 RFC2 PCNA WRN RBBP8 RPA2 ELL RPA3 USP10 POLR2G HERC2 XRCC4 RUVBL1 POLQ DCLRE1A LOC105377022;FANCB ASCC1 GTF2H2C;GTF2H2C_2;GTF2H2 UBE2T FAN1 RCHY1 CLSPN TDG UBA7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MGMT KDM4B UBE2B SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR BIN2 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 PSEN2 TAB2 APH1A ADAM17 APOE EGFR ITCH PSENEN GABRB3 PIK3R1 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism NEU3 UGT8 ARSJ NEU1 PSAP ARSH ARSI B4GALNT1 ASAH1 CTSA M6PR B4GALT6 ST6GALNAC5 CERK HEXB ST3GAL3 SMPD1 A4GALT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death TFDP1 TFDP2 CDC37 DSP PTK2 SATB1 ITCH GZMH;GZMB-1 CASP3 C1QBP GSDME SPTAN1 BIRC2 BIRC3 PKP1 LY96 FAS RIPK1 GSDMD PLEC TRAF2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TLR4 PSMD8 CASP1 PSMA6 PDCD6IP PSMD12 PSMD11 DCC PSMB1 CTNNB1 PSMC2-1 PSMA7 CHMP2B MAPK1 NMT1 AKT2 AKT3 CHMP3 H1-3 H1-2 MAPT CLSPN H1-5 CHMP6 PELI1 AKT1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling KIT SH2B3 CBL SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CASP3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition TFDP1 TFDP2 PSMD8 PSMA6 PSMD12 PTK6 PSMD11 LIN52 PSMB1 PSMC2-1 PSMA7 AKT2 AKT3 CCNA1 CCNE1 AKT1 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors AVPR1B DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid LIPF CLPS DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species TXNRD1 GPX7 CYBB CYBA ATOX1 SOD2 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex POLA2 RPA3 GMNN ORC1 ORC2 CDC45 MCM8 RPA2 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3R1 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly MTTP APOC1 APOB APOA2 PRKACB-1 APOC3 APOA1 APOE APOA4 APOC2 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA NUDT21 SNRPF SNRPE-2 PCF11 SNRPG-2 PABPN1-1 ZNF473 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL HADHA HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD11B1 TSPOAP1 CYP11B1;CYP11B2 STARD3 STARD3NL AKR1B1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 MAPK1 FGF22 SPRED2 SPRED1 CBL PTPN11 FRS2 FGFRL1 PIK3R1 GAB1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER POLR2L RPA3 POLD4 RFC1 GTF2H3 POLR2G RBX1 DDB1 USP7 ISY1;ISY1-RAB43 RFC5 ERCC3 RFC3 RFC4 XAB2 GTF2H2C;GTF2H2C_2;GTF2H2 RFC2 PCNA RPA2 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants ICOS RBX1 GZMH;GZMB-1 PRKAR1A BCL2A1 DCTN1 ALK IRS1 FOXM1 FRS2 PIK3R1 PRF1 GCC2 TPM3 MYH9 CCNB1 SEC31A MAPK1 BCL11A MDM2-2 HIP1 NPM1-2 EEF1G RNF213-2 HDAC1 STRN TYK2 JUN ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels GNB2 KCNJ3 KCNJ5 GABBR2 KCNJ10 GNB1 GNB4 KCNJ15 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A5 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation HDAC1 TCF7L1 CDKN2A CTNNB1 CCNB1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport ANK2 SPTBN4 SPTB CAPZA1 GOLGA2 ANK1 DCTN1 SPTAN1 RAB1B SEC22B INS;INS-IGF2 TRAPPC4 TRAPPC10 SEC13 MIA2 TRAPPC6A DYNC1I2 TRAPPC6B DCTN2 TMED7 TMED9 COG1 ACTR1A PREB SEC31A AREG KDELR2 COG8 COG6 ANKRD28 DYNC1H1 PPP6C COG2 BET1L SEC23IP GORASP1 ACTR10 LMAN2 CSNK1D SEC22C PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA AEBP2 PHF19 EPOP EZH2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth PRNP MAPK1 CACNA1I GDNF COL4A5 SPTAN1 CACNA1H SPTBN4 PTK2 SPTB COL4A4 COL6A3 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation MAPK1 JAK1 DUSP10 PTPN11 TYK2 MAP2K2;MAP2K1 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors RXFP1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 MLLT3 POLR2G GTF2H3 SUPT6H SSRP1 CTR9 GTF2F1 AFF4 ELL ERCC3 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis ELOVL6 SCD FASN ACLY ACSL3 HACD1 ELOVL5 PPT1 ELOVL1 TECR MORC2 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC19A3 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends RPA3 ATR RAD9A PPP4C HERC2 H2BC15;H2BC3;H2BC11;H2BC12 EXO1 RHNO1 RFC5 RFC3 RFC4 RFC2 CCNA1 WRN CLSPN BARD1 RBBP8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RPA2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors LTB4R2 CYSLTR1 PTGIR PTGER2 PTGER3 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy TBK1 MFN1 VDAC1 UBE2V1 MFN2 UBE2D3;UBE2D2 VDAC3 TOMM7 ATG5 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization FLT4 KDR DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells AREG NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency NAGS WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 WNT5A AP2A1 AP2A2 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) EXOSC2 PPP2R5B EXOSC1 ERN1 KLHDC3 DCSTAMP GFPT1 CREB3 DCTN1 CREB3L1 EIF2S2 EIF2S3;EIF2S3B MBTPS1 SYVN1 PREB SEC31A CXXC1 HSP90B1 DIS3 CXCL8 EXOSC6 EXOSC4 EXOSC9 EXOSC8 DCP2-1 YIF1A DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state ARRB1 KIF7 PSMD8 RBX1 PSMA6 PSMD12 PSMD11 ITCH CDON SMO PSMB1 PSMC2-1 PSMA7 DZIP1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 GNE NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways NUP85 NUP88 KPNA4-1 SEC13 NUP133 PABPN1-1 NUP205 NUP107 GBP2;GBP3;GBP1 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle RBBP6 CDC37 DDX39B TMOD3 TXNL1 ACTN1 MYO6 STK38 CCT7 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK10 KCNK2 KCNK4 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway RFC3 RFC4 RPA3 PARG RFC2 POLB POLD4 PCNA RFC1 PARP2 RPA2 RFC5 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant F10 F9 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation ORC1 ORC2 MCM8 CCNB1 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA9 CHRNB2 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT CMA1 KIT MMP9 SH2B3 CBL GRAP TEC PTPN11 PIK3R1 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC1 APOBEC2 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor LRRC7 RASGRF2 CAMK2A CAMK2G CAMK2B CAMK2D REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription KCNIP3 NR3C1 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type GPC3 GPC2 GPC4 SDC3 CSPG5 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling JAK1 IL2RB IL15 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins XPC AR PIAS3 SUMO1 CBX4 SATB1 VDR RARA NR3C1 BMI1 ING2 PHC3 TOP2B SMC6 NOP58 PCNA NSMCE1 WRN NSMCE4A NUP205 NUP107 PML NUP85 NUP88 SEC13 NUP133 HERC2 XRCC4 SATB2 MDM2-2 NPM1-2 HDAC1 MITF PCGF2 TDG SMC3 STAG2 NRIP1 CTBP1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes RIPK2 MYD88 IRAK1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol MPHOSPH6 RPL18 RPL37A-1 RPS15 RPS11 RPS13 RPL4 RPL30 DIS3 RPL31 EXOSC6 CSNK1D EXOSC4 RPL6 EXOSC9 RPL7 EXOSC8 EXOSC2 RPL35 EXOSC1 RPL38 RPL39 RIOK2 GNL3 RPL22 EBNA1BP2 NIP7 ISG20L2 BYSL NOP58 RPL29 RPL7A UTP6 DDX49 UTP11 FCF1 NAT10 WDR75 RPS25 NOC4L RPS27 IMP4 DDX52 RPS29 RRP9 RCL1 RRP7A PDCD11 FAU DKC1 BMS1 RPS21 DCAF13 RPS24 UTP14C;UTP14A RPP40 NOP10 RPP21 RPP14 TRMT112 XRN2 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression KCNIP3 NR3C1 TNRC6A-1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) MDH2 NNT IDH2 SDHC SDHAF1 SDHB OGDH TRAP1 LYRM4 IDH3B GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis ST6GALNAC5 UGT8 CERK B4GALNT1 ST3GAL3 B4GALT6 A4GALT FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants CBL FLT3 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation NMT1 NOSIP SPR AKT1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation RHOA RAB14 DYNLT1 SERPINB1 S100A7A;S100A7 RAB7A PKP1 GSDMD RNASE3;RNASE2-2 S100A9 PSMD12 PSMD11 PSMB1 PSMC2-1 RAP1A FRK CTSH MAPK1 C3AR1 MAPK14 ACTR10 MGST1 NEU1 CTSA LRRC7 DERA CFD PLAU GNS SERPINB6-2 PAFAH1B2 LAMTOR2 RAB27A PTPRJ ITGAV TCN1 GAA AMPD3 GPI PYGB AGL-1 PYGL HEXB CFP AP2A2 DSP PECAM1 SLC44A2 ASAH1 CKAP4 ATP8A1 TCIRG1 CPNE3 ATP11B FABP5 CSNK2B IDH1 CYBB CYBA SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 ABCA13 MAGT1 HP;HPR MAN2B1 PA2G4 TOLLIP ACLY PLEKHO2 SERPINB10 DYNC1H1 IQGAP2 SLCO4C1 RAB3D ANO6 LAMP1 GOLGA7-1 BIN2 PKM LAMP2 ILF2 NCKAP1L RAB37 RAB5C ARL8A PTPRB PSAP SNAP29 SIRPB1 CANT1 PRCP CPPED1 FTH1 ANPEP HPSE CTSG PDXK SLPI CRISPLD2 SPTAN1 MMP9 VAT1 PRG3 ACTR2 PRSS3;PRSS2;PRSS1 ITGAM ORM2;ORM1 PGM2 CD63 CAB39 RHOF ENPP4 PGM1 PYCARD IRAG2 DPP7 STOM FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 FFAR1 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint UBE2C PSMD8 PSMA6 CDC26 PSMD12 ANAPC1 PSMD11 ANAPC10 ANAPC11 PSMB1 PSMC2-1 PSMA7 CCNA1 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJC2 GJB4 GJA9 GJA8 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants FLT3 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN TBK1 NLRP4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus JAG2 MIB2 PSEN2 APH1A PSENEN MDK JAG1 MIB1 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea MYO7A EPS8 STRC CDH23 KCNMB1 XIRP2 KCNN2 TPRN MYH9 SPTAN1 RIPOR2 RDX CHRNA9 CIB2 PJVK B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression POLR2L TAF1D H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MYBBP1A DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function WRN BARD1 RBBP8 PALB2 EXO1 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy MFN1 UBE2V1 MFN2 EPAS1 PRKAG3 PIK3R4 MLST8 GABARAP ATG101 ATG3 GABARAPL2 ATG13 ATG4A CSNK2B ATG4D LAMTOR2 CSNK2A1;CSNK2A3 UBE2D3;UBE2D2 DYNC1I2 CHMP2B TBK1 PRKAG2 PLIN2 CHMP3 VDAC1 DYNC1H1 CHMP6 TSC2 VDAC3 TOMM7 ATG5 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors LRRC7 CAMK2A LIN7C CAMK2G GRIN3B CAMK2B GRIN3A CAMK2D REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity CAMK2A LBR HDAC1 CAMK2G CAMK4 CAMK2B TNRC6A-1 CAMK2D ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases GSDMD SERPINB1 CASP3 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 BTRC FZR1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants ALK ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters SLC25A10 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System UNC93B1 TLR7 TLR4 S100A9 FGB FGA BTK F12 S100A1 FGG F2 MYD88 KLKB1 LY96 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity PSMD8 MSX2 PSMA6 RBX1 PSMD12 PSMD11 NR3C1 ESRRA PSMB1 PSMC2-1 PSMA7 PPARGC1B RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C KIF18A WAPL KIF2C AHCTF1 NUF2 NUDC NUP107 RPS27 NUP85 SEC13 PPP1CC NUP133 DYNC1I2 CENPA NSL1 CCNB2 CCNB1 DYNC1H1 SKA1 SKA2 SMC3 CENPF STAG2 CENPI TAOK1 CENPM PPP2R5E AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME SLC28A2 NME1 XDH SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C SUMO1 KIF18A LEMD3 KIF2C WAPL PSMD8 UBE2C PSMA6 CDC26 PPP1CC ANAPC1 PSMD12 DYNC1I2 PSMD11 ANAPC10 ANAPC11 PSMB1 CCNB2 PSMC2-1 PSMA7 CCNB1 TUBA1A DYNC1H1 SKA1 SKA2 AHCTF1 NUF2 EMD NUDC NUP205 NUP107 RPS27 LBR NUP85 RCC1 SEC13 NUP133 CENPA NSL1 PPP2R2A;PPP2R2D CHMP2B TUBB2B;TUBB2A CHMP3 TUBAL3 CHMP6 SMC3 CENPF STAG2 CENPI TAOK1 CENPM PPP2R5E DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress EXOSC2 EXOSC1 DIS3 EXOSC6 CXCL8 EXOSC4 EXOSC9 EXOSC8 DCP2-1 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation LRRC7 CAMK2A CAMK2G CAMK2B CAMK2D DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling PRKACB-1 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane C2CD5 PRKAG3 TBC1D4 RAB13 SLC2A4 MYH9 RAB14 PRKAG2 AKT2 MYO5A EXOC7 AKT1 RAB11A TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP3 CHMP6 PIK3R4 CHMP2B SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3R1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress RPA3 ATR RAD9A CDC45 MCM8 RFC5 RFC3 RFC4 RFC2 ORC1 CLSPN ORC2 RPA2 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors KCTD1 PITX2 NPM1-2 KCTD15 KDM5B KIT SUMO1 ATAD2 APOE EGFR MYBL2 YY1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence ASF1A H1-3 CCNA1 H1-2 H1-5 CCNE1 HMGA2 TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair POLD4 RFC1 MUS81 SUMO1 PARP2 EME1-1 EME2 DDB1 PALB2 SLX1A;SLX1B H2BC15;H2BC3;H2BC11;H2BC12 EYA1 EYA3 APBB1 DCLRE1C TDP2 POLL NHEJ1 PSMD8 PSMA6 PSMD12 PSMD11 PPP4C PSMB1 PSMC2-1 RHNO1 PSMA7 POLH CCNA1 RTEL1 BARD1 PRKDC ATR RAD9A RBX1 EXO1 RFC5 RFC3 RFC4 RFC2 PCNA WRN RBBP8 RPA2 RPA3 HERC2 XRCC4 POLQ CLSPN H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KDM4B NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle TSPOAP1 RIMS1 PPFIA4 CPLX1 PPFIA3 PPFIA2 MAOA PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling PRKACB-1 PRKAR1A PRKAR2A PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C UBE2C CDC26 ANAPC1 ANAPC10 ANAPC11 CCNB1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells CBFA2T2 POU5F1;POU5F1B PDPN NANOG;NANOGP8 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) PSMD8 PSMA6 PSMD12 PSMD11 CD207 PSMB1 PSMC2-1 PSMA7 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HMBS UROD REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) HDAC1 GATAD2A H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair POLR2L COPS7B XPC COPS7A MCRS1 POLD4 PIAS3 RFC1 GTF2H3 SUMO1 PARP2 RBX1 RAD23A RAD23B DDB1 COPS8 ISY1;ISY1-RAB43 YY1 RFC5 ERCC3 RFC3 RFC4 XAB2 RFC2 PCNA RPA2 ELL RPA3 POLR2G RUVBL1 USP7 GTF2H2C;GTF2H2C_2;GTF2H2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation FGF7 FGF22 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription EPAS1 TEAD2 H2BC15;H2BC3;H2BC11;H2BC12 TEAD3 TEAD4 CTNNB1 BRD4 TCF7L1 EZH2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUN DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation F11 F9 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling GNAZ GPER1 PRKACB-1 GNB2 GNB1 PRKAR1A PRKAR2A GNB4 GNAI2 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis RPA3 USP10 POLD4 RFC1 RFC5 RFC3 RFC4 RFC2 REV1 POLH PCNA UBA7 RPA2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGG PIGV TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 NUP88 SEC13 NUP133 NUP205 NUP107 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 GPC3 GPC2 GPC4 SDC3 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release PRELID3A PRELID1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER COPS7B XPC MCRS1 COPS7A PARP2 RBX1 RAD23A RAD23B DDB1 COPS8 RUVBL1 YY1 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA SNW1 HNRNPA1-1 DDX39B THOC1 DHX38 THOC3 THOC6 SMG5 SMG6 HNRNPA2B1 SNRPA1 TP53RK RPL4 RPL30 RPL31 PABPN1-1 EIF4E EIF4B RPL6 CNOT6 RPL7 CNOT7 RPL35 CNOT9 RPL38 RPL39 PNPT1 REXO2 LRPPRC RIOK2 GNL3 RPL22 EBNA1BP2 NIP7 ISG20L2 BYSL RPL29 UTP6 DDX49 UTP11 FCF1 NAT10 WDR75 NOC4L IMP4 DDX52 RRP9 RCL1 RRP7A PDCD11 DKC1 BMS1 DCAF13 UTP14C;UTP14A NOP10 PPP2R2A;PPP2R2D TRMT112 NGRN GSPT1 RPL18 ETF1 RPL37A-1 HNRNPR CSNK1D PQBP1 ISY1;ISY1-RAB43 SF3B6 XAB2 NUDT21 PHF5A SNRPN CHERP RPL7A CTNNBL1 PUF60 PPIL4 POP7 POP1 POP4 SRRM2 RPP40 RTCB RPP21 C2orf49 RPP14 RTRAF SUGP1 YRDC GTF2H2C;GTF2H2C_2;GTF2H2 MTO1 RBBP6 TRMT61B PCF11 HSD17B10 PPIL1-1 POLR2L WBP11 PRPF6 PPIH GTF2H3 PPIG SNUPN PRPF8 ERCC3 BUD31 APOBEC1 APOBEC2 ADAR ADARB1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 ZNF473 PSMC2-1 PSMA7 PABPC1;PABPC3 DIS3 MAPK14 EXOSC6 ZFP36 EXOSC4 EXOSC9 EXOSC8 AKT1 NSRP1-1 DCP2-1 EXOSC2 PPWD1 PNN EXOSC1 RBMX2 SNRNP35 METTL3 PRPF4B PRPF40A CXorf56-1 PRPF18 PRPF3 C9orf78 SNRNP27 SNRNP25 SNRPC CACTIN CWF19L2 DHX35 SRSF10 PRPF38A PPIL2 CCDC12 LSM2 LSM8 NUP205 NUP107 NUP85 NUP88 POLR2G SEC13 NUP133 TRMT10C GTF2F1 PRORP YTHDC1 ZC3H4 ZC3H18 DXO MPHOSPH6 GEMIN2 RPS15 RPS11 RPS13 SNRPF DDX20 NOP58 SNRPE-2 SNRPG-2 TGS1 RPS25 RPS27 RPS29 FAU PUS3 RPS21 CTU2 RPS24 TRMT10A TRMT6 TPRKB TRMT13 C9orf64 TRMT61A ADAT3 XRN2 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab CDC37 ERBIN GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants FLT3 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm FOXA2 TEAD2 TEAD4 CTNNB1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria AKT2 AKT3 AKT1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 JAG2 MIB2 PSEN2 HES5 MAMLD1 APH1A FCER2 GZMH;GZMB-1 PSENEN MDK JAG1 MIB1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand POLA2 RPA3 POLD4 PCNA RPA2 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A6 SLC27A1 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity SV2A SYT2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 GTF2F1 ERCC3 HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation HPSE GPC3 GPC2 GPC4 SDC3 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d ALG3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation APOE CKAP4 KTN1 GPC3 CALU LAMB2 MBTPS1 BPIFB2 FBN1 CDH2 APOA2 MEN1 APOA1 MGAT4A-1 PRSS23 FGA APOB CCN1 IGFBP5 IGFBP4 MXRA8 HSP90B1 FGG VWA1 FAM20A MSLN CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions CDH24 CDH8 CTNNB1 CDH11 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase PLEC DSP PTK2 SATB1 CTNNB1 CASP3 H1-3 H1-2 MAPT SPTAN1 H1-5 CLSPN BIRC2 PKP1 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression TGS1 ARNTL2 NCOA6 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling UBE2V1 RBX1 NOD1 IRAK1 IL1R2 MAP3K8 TRAF2 PSMD8 TAB2 PSMA6 PSMD12 PSMD11 IL1R1 PSMB1 PSMC2-1 PSMA7 MAP2K2;MAP2K1 TOLLIP BTRC RIPK2 USP14 NKIRAS1 NKIRAS2 PELI1 MYD88 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression POLR2L SAP130 GTF2H3 UBTF SAP30BP H2BC15;H2BC3;H2BC11;H2BC12 SAP30 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 TAF1D SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins CDH24 SNAI1 CDH8 ZC3H12A ILF3 CTNNB1 TNRC6A-1 HOXC8 CDH19 CDH11 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers SNW1 POLR2L HDAC5 MAMLD1 CDK8 FGFR3 CBL ESRP1 BCL2A1 DCTN1 HES5 MIB2 PSMD8 PSMA6 BDNF PSMD12 PSMD11 MYH9 FLT3 PSMB1 TGFBR1-1 CTNNB1 PSMC2-1 RAP1A PSMA7 MAP2K2;MAP2K1 MAPKAP1 MAPK1 MDM2-2 NPM1-2 AKT1 PIK3R5 RBX1 PRKAR1A MLST8 SMAD4 SPRED3 SPRED2 SPRED1 NF1 CAMK2B CAMK2D CAMK2A CAMK2G PSEN2 POLR2G APH1A PSENEN GTF2F1 FGB FGA FGG PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CDC37 ERBIN PHB GZMH;GZMB-1 JAG1 KIT ALK IRS1 FRS2 PIK3R1 PPP1CC TPM3 EGFR SYVN1 BCR KLB CCNB1 CLCN6 AKT2 AKT1S1 AKT3 FGF19 STRN FGFR1OP2 DKK1 BIN2 TYK2 CTBP1 ZC3HAV1 ICOS JAG2 ARRB1 AP3B1 ERLIN2 APBB1IP MRAS MAP3K11 IRS2 HHAT ADAM17 PIK3CG FZD4 FOXM1 FZD6 DUSP10 PTPN11 KSR2 PRF1 GCC2 KDR HGF SEC31A GAB1 BCL11A AREG HIP1 EEF1G RNF213-2 CSK FGF7 HDAC1 FGF22 ZMYM2 CCNC-1 TSC2 KREMEN1 AGTRAP MIB1 JUN ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding CSNK2B GNA14 CSNK2A1;CSNK2A3 GNB2 GNB1 PDCL GNB4 CCT7 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo WWC1 LATS1 CASP3 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation FBN2 ITGAV FBLN5 LOXL3 MFAP5 LOXL1 TGFB2 FBN1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis GLRX5 LYRM4 HSCB NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 PSEN2 TAB2 APH1A ADAM17 APOE PSENEN RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression FASN ACLY ACACB REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling TRAF2 USP14 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors MAPK1 MAPK14 JUN DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins BTRC PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 CRY1 PSMC2-1 PSMA7 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells EPHA5 MMP9 PSEN2 APH1A EPHA4 PSENEN AP2A1 AP2A2 EPHB1 EPHB4 EPHB3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PTGES3-1 PTGDS PTGR2 CBR1-1 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation POLR2L SNRPF PRPF40A SNRPC SF3B6 SRSF10 NUDT21 PHF5A HNRNPA1-1 SNRPE-2 SNRPN SNRPG-2 CHERP HNRNPA2B1 PUF60 SNRPA1 POLR2G SRRM2 GTF2F1 SUGP1 RBBP6 PCF11 HNRNPR XRN2 PABPN1-1 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events NUP85 NUP88 SEC13 NUP133 EGFR DYNC1I2 H2BC15;H2BC3;H2BC11;H2BC12 DYNC1H1 EZH2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 NUP205 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP107 PML RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib CDC37 ERBIN PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions ITGAV PECAM1 PTPN11 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle TSPOAP1 RIMS1 PPFIA4 CPLX1 PPFIA3 GLS2 PPFIA2 GLS DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B1;CYP11B2 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation CD3G PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism TAT SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification GNA14 GNB2 MAPK14 GNB1 P2RY1 GNB4 GNAI2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation GNB2 KCNJ3 KCNJ5 GABBR2 KCNJ10 GNB1 GNB4 KCNJ15 GNAI2 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHB MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling GGA3 HGF CRK GAB1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription ZFHX3 SMAD4 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking KLC2 ANK2 RACGAP1 KIF1C SPTBN4 KIF21B SYT2 SPTB KIF27 CBL KIF18A KIFC1 RAB14 CAPZA1 KIF2C GOLGA2 DCTN1 EPS15 MYO5A SEC22B RAB7A MYH9 COG8 APOB CYTH4 COG6 RAB36 COG2 BET1L ACTR10 GJC2 GJB4 GJA9 AKT1 GJA8 SYT9 SLC18A3 UBQLN2 AP1G2 PRKAG3 ANK1 MAN1A1 GDI1 RAB1B GABARAP GGA3 TBC1D13 TRAPPC11 EXOC7 TBC1D10B GNS TSG101 DENND2D GABARAPL2 RAB11A ANKRD27 DENND4B BICD1 INS;INS-IGF2 DENND2B PAFAH1B2 MVB12A TRAPPC4 BICD2 TRAPPC10 RAB27A TRAPPC8 SEC13 RAB11B USE1 TRAPPC6A TRAPPC6B VPS52 ARFIP2 RAB13 TBC1D24 TMED7 RAB38 TMED9 DENND6B NAA30 RINT1 PREB DENND6A RIN2 CHMP2B NAA38 KDELR2 PRKAG2 UBAP1 CHMP3 CHMP6 AP2A1 AP2A2 COPS7B COPS7A COPS8 VPS25 PICALM AMPH C2CD5 FNBP1 MIA2 TBC1D4 EGFR DYNC1I2 DCTN2 SLC2A4 ACTR1A AKT2 AKT3 STAM2 RHOBTB3 CD3G DYNC1H1 CSNK1D MYO6 TBC1D8B RAB5C SORT1 HIP1R ARRB1 ARPC4 SNAP29 AP3B1 TPD52L1 BLOC1S4 BLOC1S1 DNAJC6 FTH1 BLOC1S3 ACTR3-1 AP1S3 M6PR SYNJ1 SPTAN1 ACTR2 FZD4 WNT5A GCC2 IL7R COG1 SEC31A AREG HIP1 SH3KBP1 ANKRD28 PPP6C SEC23IP GORASP1 TSC2 LMAN2 SEC22C KIF12 RAB9A SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins IL13 PTPN13 CBL TNF BATF CAPZA1 CRK CCL3L1;CCL3L3;CCL3;CCL18 BLNK TNFRSF1A NOS2 MEF2C MAP3K8 SOD2 CFL1 HNRNPA2B1 PDCD4 IL12B GSDMD TRAF2 SNRPA1 IL12A IL12RB1 PSMD8 IL12RB2 PSMA6 PSMD12 PSMD11 TALDO1 IL21 PSMB1 PSMC2-1 PSMA7 MAP2K2;MAP2K1 MAPK1 HSP90B1 MAOA MAPK14 CSF2 AKT1 LIFR RBX1 IL2 PTPN7 IL34 MUC1 PPP2R5D FCER2 IRS1 IL21R PIK3R1 HSPA9 IL20RA NANOG;NANOGP8 TBK1 TOLLIP BTRC IL33 JAK1 IFNL2;IFNL3;IFNL1 CA1 RIPK2 IL10RB USP14 NKIRAS1 NKIRAS2 CRLF2 PELI1 MYD88 TYK2 IL13RA1 UBE2V1 PTPN20 IL2RB NOD1 CSF2RA PTPN2 IRAK1 CASP3 EBI3 IL1R2 CTSG CRLF1 IRS2 MMP1 MMP9 IFNLR1 ITGAM IL25 IL15 IL19 PTPN11 OSMR IL18R1 RAG2 RAG1 IL17F TAB2 CASP1 IL7R IL17A IL1R1 TEC HGF CCL22 CXCL8 CCL20 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUN CDC42 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors PITX2 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects TFDP1 E2F2 TFDP2 FZR1 CDK6 UBE2C E2F3 CCNE1 CDC26 ANAPC1 ANAPC10 ANAPC11 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi MAN1A1 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression DAD1 ERLIN1 RBX1 RPN2 EPAS1 PRKAG3 PDCD1LG2 ERLIN2 RPN1 H2BC15;H2BC3;H2BC11;H2BC12 BRD4 MIB2 EZH2 TNRC6A-1 CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 STT3B PSMD12 PSMD11 TEAD2 TEAD3 TEAD4 PSMB1 MAGT1 CTNNB1 PSMC2-1 PSMA7 PRKAG2 BTRC JAK1 TCF7L1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUN TMEM258 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 CHCHD1 MRPS28 PTCD3 MRPS23 MRPL49 MRPS2 MRPL47 MRPS7 MRPL43 MRPL21 LOC107987373;MRPL23 MRPL52 MRPS17 MRPS16 MRPS33 MRPL18 MRPL19 MRPS31 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling IL12B IL12RB1 TYK2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) RPA3 POLD4 PCNA EXO1 RPA2 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling FGB FGA CSK PTK2 FGG APBB1IP RAP1A AKT1 CRK DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation POLR2L SNAPC1 SNAPC2 POLR3A POLR3D POLR3F GTF3C2 POLR3K GTF3A BRF2 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism NUP85 SNRPF NUP88 SEC13 SNUPN NUP133 DDX20 GEMIN2 SNRPE-2 SNRPG-2 TGS1 NUP205 NUP107 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism MTM1 INPP5F PIP4K2C PLEKHA6 TNFAIP8L1 PTPN13 PIK3R4 PITPNB RAB14 INPP4A SYNJ1 PI4K2B GDPD1 PIK3CG PIK3C2B GDPD5 MTMR4 PIK3R1 MTMR6 PIK3R5 MTMR7 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling PREX1 PSEN2 APH1A BEX3 RHOA PSENEN CASP2 IRAK1 CASP3 RASGRF2 HDAC1 ARHGEF11 RIPK2 ADAM17 ARHGEF15 MYD88 ARHGEF17 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers BCL11A PHF10 PBRM1 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes COX7C LAMTOR2 TXNRD1 COX6C PRKAG3 MLST8 COX6A1 GPI COX6A2 PRKAG2 AKT2 SCO2 AKT3 G6PD GLS2 TSC2 TNRC6A-1 GLS AKT1 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition LCMT1 CCNA1 FZR1 FOXM1 CCNB2 CCNB1 PKMYT1 PPP2R2A;PPP2R2D METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals MT2A RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle LBR PREX1 MCAM CDC42EP1 ERBIN OPHN1 DIAPH3 NDUFS3 LEMD3 MAP3K11 KTN1 DOCK1 EMD IQGAP2 RAB7A PIK3R1 ARHGDIG CDC42 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 CHCHD1 MRPS28 PTCD3 MRPS23 MRPL49 MRPS2 MRPL47 MRPS7 MRPL43 MRPL21 LOC107987373;MRPL23 MRPL52 MRPS17 MRPS16 MRPS33 MRPL18 MRPL19 MRPS31 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins SV2A TXNRD1 CD9 PDCD6IP SYT2 MAP2K2;MAP2K1 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL PSMD8 DACT1 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) TAAR5 FSHR TSHR GPHB5 RXFP1 GPR37L1 KEL CHRM5 CENPS-CORT;CORT;CENPS MLN BDKRB2 NPBWR1 BDKRB1 GALR1 DRD4 NPBWR2 DRD5 PROK1 CCL3L1;CCL3L3;CCL3;CCL18 OPN3 LTB4R2 PNOC GRP GPER1 LPAR1 LPAR2 LPAR3 PTGIR LPAR4 GPR35 PROKR1 P2RY2 P2RY1 PTGER2 TAC3 PTGER3 OPN4 NMB P2RY11 S1PR3 XCL1;XCL2 CCK S1PR2 LPAR5 P2RY13 NMS GPR55 FFAR3;GPR42 F2RL2 APLN ACKR1 C3AR1 NPY CYSLTR1 OPN1SW PSAP MCHR1 FFAR1 ADRA2A CCL13;CCL2 F2 CCL22 CXCL8 AVPR1B CCL20 ACKR4 CXCL5;CXCL6 HTR6 HTR1A DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses GNS NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response PSMD8 PSMA6 RBX1 BARD1 PSMD12 DDB1 PSMD11 PSMB1 PSMC2-1 PSMA7 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants PPP1CC MRAS MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C7 C9 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) SNW1 TFDP1 TFDP2 MTERF1-1 MAMLD1 TFB2M ZFPM1 SOD2 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BDNF GCK TP53RK USP7 RHNO1 AFF4 MEAF6 MAPKAP1 MAPK1 MDM2-2 NPM1-2 PCBP4 DICER1 BCL2L14 CCNA1 MLLT3 PRELID3A SUPT6H BANP BARD1 PABPN1-1 FANCI RRN3 PRELID1 CRADD FANCC CNOT6 CNOT7 GLS JMY PIN1 CDK12 CNOT9 ATR PIP4K2C RAD9A BTG2 DYRK2 SETD9 PRKAG3 ING5 PIDD1 ING2 EXO1 MLST8 MED8 CASP2 ZNF385A RFC5 RFC3 RFC4 SCO2 RFC2 RABGGTA PCNA WRN PERP PLAGL1 RBBP8 RFFL E2F7 E2F8 RPA2 HIPK1 POU4F1 PML TTC5 RPA3 LAMTOR2 KDM5B PBRM1 GPI PRKAG2 AR SUMO1 VDR RARA NR3C1 KIT DGAT2 BRF2 CSNK2B CSNK2A1;CSNK2A3 LPIN1 PRKCB MGLL SSB EGFR NFIB CCNB1 CENPJ AJUBA ESRRA G6PC1 TSNAX NUDT21 GTF3C2 GTF3A INTS3 INTS2 PHF20 INTS7 AKAP8L INTS11 PSIP1 LBR INTS13 MED16 MED17 NABP2 SAP130 SNAPC1 SNAPC2 UBTF PHLDA1 RPRD2 MEN1 SAP30BP ARNT BOD1L2;BOD1 NCOA6 ELOVL5 HCFC1 SAP30 CTR9 MED23 MED24 AEBP2 PLIN2 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 CXXC1 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 PCF11 GLS2 USP9X TAF1D SAP30L TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZNF324B;ZNF324 MORC2 PPARGC1B POLR2L ZNF382 SETD1B MCRS1 ZNF669;ZNF670 HDAC5 GTF2H3 TXNRD1 CBX4 EPOP CIDEC GATAD2A BMI1 CDK8 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 FABP4 TADA2A MYBBP1A YY1 MAF CDK5 ERCC3 YEATS2 KANSL2 SCD MED31-1 MPHOSPH8 PHF19 EZH2 MEF2C ZNF605 ZNF555;ZNF57;ZNF556 ZNF713 ZNF157 ZNF398 TWIST2 ZNF707 PSMD8 NKX2-5 UCMA PSMA6 CTLA4 ZNF248 PSMD12 TEAD2 PSMD11 TEAD3 TEAD4 ZNF599 PSMB1 ZNF473 CTNNB1 PSMC2-1 SERPINB13 SATB2 PSMA7 ZNF557;ZNF558 NPY ZNF226 ZNF583 CDKN2B PCGF2 ATAD2 RYBP CAMK4 MAPK14 AGRP ZNF697 ZFP28 ZNF573 CSF2 AKT1 ZNF274;ZNF74 ZFP30 ZNF567 ZNF445 PITX2 ZNF202 ZNF160;ZNF347;ZNF665-1 MSX2 LIFR RBX1 FOXP3 APOE NRBP1 PCK1 ITCH PVALB ZNF793 ZNF791 KRBA1 ZNF546 ZKSCAN5 ZNF664 ZFHX3 SMAD4 AUTS2 ESRRB IL2 CDK6 ZNF426-1 ZNF771 LDB1 DGCR8 MYBL2 ZNF641 RBM14 ZNF75A CAMK2B ELL CAMK2D COX7C TAF7L CAMK2A INS;INS-IGF2 ZNF746 E2F6 CAMK2G ZNF740 POLR2G ZNF747;ZNF764 ZNF184 KCNIP3 MGA TBX5 TAF12 ZNF614 TAF13 TAF11 SSRP1 GTF2F1 TDRKH-1 MYBL1 TAF7 TAF5 TAF2 POLR3A POLR3D POLR3F POLR3K XPO5 ARNT2 BCDIN3D PPP2R5C COX6C JAG1 COX6A1 COX6A2 HNF4A G6PD TNRC6A-1 BRD2 KCTD1 KCTD15 FZR1 UBE2C CDKN2A CDC26 ANAPC1 ANAPC10 ANAPC11 AKT2 AKT3 SNRPF ANG IRAK1 SNRPE-2 SNRPG-2 PTPN11 CASP1 TCF7L1 CCNE1 MYB TSC2 GATA1 NOTCH3 JUN ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling IRS2 IRS1 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation GLYATL3 ACSM5 ACSM4 GLYAT BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDHB BCKDK REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation TBK1 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms NOXA1 FZD7 WNT5A CYBA JUN TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants FLT3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ZP3;POMZP3 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR RPA3 POLD4 PCNA EXO1 RPA2 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) CYP2D6;LOC107987479;LOC107987478-1 LTC4S MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) FGB FGA BTK TLR4 S100A9 S100A1 FGG MYD88 LY96 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) BCL11A PHF10 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling GDNF IRS2 DOK6 PRKACB-1 DOK1 PTPN11 FRS2 PIK3R1 GAB1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins MUC1 MUC4 ST6GALNAC3 MUC21 B4GALT6 GALNT14 ST3GAL4 B3GNT2 GALNT9;GALNT17 GALNT16 GALNT15 GCNT1 GALNT10 ST6GAL1 ST3GAL1 GALNT9 B3GNT6 ST3GAL3 MUC5B PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation KCNE5 KCNQ1 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses JAK1 RBX1 DDX58 TYK2 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria AUH DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 NOTCH3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization BTK TXK PPP3CB PLCG2 ITK AHCYL1 TEC FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA PHLDA1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACBD6 ACOT12 ACOT9 MCEE MECR ACAA2 HADHA ACOT2;ACOT1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells BTRC PSMD8 PSMA6 PRKCB REL PSMD12 PSMD11 NFKBIE PSMB1 PSMC2-1 PSMA7 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA POLR2L XPO5 BCDIN3D ANG POLR2G H2BC15;H2BC3;H2BC11;H2BC12 TDRKH-1 TSNAX MYBL1 DICER1 DGCR8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TNRC6A-1 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI MBOAT7 PLAAT3 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs MAPK1 JAK1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction TNNI3 MYBPC3 TMOD1 MYL4 TMOD3 TTN-1 TPM3 TNNT2 TNNT3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR PIGK PIGS CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC5A1-1 SLC5A4 SLC2A12 SLC2A4 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling MTTP CETP APOB APOA2 APOC3 APOA1 APOE APOA4 APOC2 MBTPS1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase PPP2R5B PPP2R5A PPP2R5D B9D2 PPP2R5C SUMO1 KIF18A LEMD3 KIF2C WAPL PSMD8 UBE2C PSMA6 CDC26 PPP1CC ANAPC1 PSMD12 DYNC1I2 PSMD11 ANAPC10 ANAPC11 PSMB1 CCNB2 PSMC2-1 PSMA7 CCNB1 TUBA1A DYNC1H1 SKA1 SKA2 AHCTF1 NUF2 EMD NUDC NUP205 NUP107 RPS27 LBR NUP85 RCC1 SEC13 NUP133 CENPA NSL1 PPP2R2A;PPP2R2D CHMP2B TUBB2B;TUBB2A CHMP3 TUBAL3 CHMP6 SMC3 CENPF STAG2 CENPI TAOK1 CENPM PPP2R5E NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL35 RPL38 RPL39 RPL22 GSPT1 RPL18 ETF1 RPL29 RPL7A RPS25 RPS27 RPS29 FAU RPS21 RPS24 RPL37A-1 RPS15 RPS11 RPS13 RPL4 PABPC1;PABPC3 RPL30 RPL31 RPL6 RPL7 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors RXFP1 PSAP GPR37L1 KEL CENPS-CORT;CORT;CENPS MLN NPBWR1 BDKRB2 GALR1 BDKRB1 NPBWR2 PROK1 CCL3L1;CCL3L3;CCL3;CCL18 PNOC GRP GPER1 MCHR1 PROKR1 TAC3 NMB XCL1;XCL2 CCK NMS F2RL2 APLN ACKR1 NPY C3AR1 CCL13;CCL2 CCL22 F2 CXCL8 AVPR1B CCL20 ACKR4 CXCL5;CXCL6 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses TBK1 NLRP4 TREX1 PRKDC TRIM21 CGAS SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins NUP85 NUP88 SEC13 CBX4 SUMO1 SATB1 NUP133 BMI1 PHC3 SATB2 HDAC1 PCGF2 NUP205 NUP107 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome PYCARD P2RX7 CASP1 SUGT1 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 SMAD4 HDAC1 ZNF423 GATAD2A RBBP7 PPARGC1B DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 GTF2F1 ERCC3 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction RDH8 RDH12 APOC3 SDC3 APOE APOC2 CLPS GPC3 GPC2 GPC4 PDE6B RCVRN DHRS9 PDE6A RETSAT MYO7A APOA2 GUCA1C APOA1 APOA4 PPEF1 NMT1 APOB GRK7 OPN1SW GNB1 RPE65 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ LMBRD1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle RHOF SRGAP2 SENP1 BAIAP2L1 MCAM FARP1 DIAPH2 DIAPH3 FAM169A ACTN1 RAB7A PIK3R1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA HDAC1 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation SMAD4 HDAC1 ZNF423 GATAD2A RBBP7 PPARGC1B MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases E2F3 CDK11A;CDK11B PKMYT1 FZR1 PSMD8 PSMA6 PSMD12 LIN52 DYNC1I2 PSMD11 DCTN2 SSNA1 CEP164 PSMB1 CCNB2 ACTR1A PSMC2-1 PSMA7 CCNB1 TUBA1A CEP250 BTRC CDK5RAP2 CCNA1 CEP78 DYNC1H1 CEP135 ODF2 CEP152 HAUS4 CSNK1D HAUS5 TUBG1 HMMR NEDD1 CENPJ ALMS1 CEP63 AJUBA RBX1 TUBGCP5 TUBGCP6 LCMT1 TUBGCP4 MYBL2 FOXM1 PHLDA1 PPP2R2A;PPP2R2D CENPF PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway MAPK1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade NMT1 GRK7 RCVRN PDE6B GUCA1C PDE6A GNB1 PPEF1 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions PPIL2 MMP1 ATP1B1 L1CAM SPN SLC7A7 SLC7A8 SLC16A3 SLC7A11 ATP1B3-1 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis HMBS UROD HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells PKN2 FLT4 PRKACB-1 KDR PECAM1 PRKAR1A PRKAR2A MLST8 CTNNB1 MAPKAP1 GNB2 RAMP2 GNB1 P2RY2 TRPV4 GNB4 AKT1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation GNMT OGDH CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis RAB5C COPS7B SYT9 COPS7A SLC18A3 HIP1R ARRB1 UBQLN2 ARPC4 SYT2 CBL DNAJC6 COPS8 ACTR3-1 M6PR SYNJ1 PICALM EPS15 ACTR2 FZD4 WNT5A AMPH FNBP1 IL7R EGFR AREG HIP1 STAM2 SH3KBP1 APOB CD3G AP2A1 AP2A2 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 CAMK2A LBR CAMK2G BDNF PVALB IRAK1 HDAC1 CAMK4 DGCR8 MEF2C CAMK2B TNRC6A-1 CAMK2D ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAG2 PRKAG3 MAPK14 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System LRRTM1 SHANK2 TSPOAP1 DLGAP4 RTN3 SYT2 SHARPIN KCNG1 KCNH6 KCNC1 GLUL KCNMB1 KCNS2 KCNMB4 KCNAB1 KCNN2 KCNAB3 CAMKK2 MAPK1 MDM2-2 MAOA CAMK4 GABRB3 GRIK5 GLS CHRNA9 GRIK4 LIN7C NRGN SYT9 GABRR3 SLC18A3 CHRND GABRR2 GABRR1 GLRA3 PRKAG3 PRKACB-1 KCNJ3 KCNJ5 GABBR2 KCNJ10 PRKAR1A GABRA4 PRKAR2A KCNJ15 GRIN3B GRIN3A GLRB LRRC7 PTPRD CAMK2B CAMK2D SLITRK2 CAMK2A SLITRK6 LRRC4B CAMK2G PRKAG2 AKAP5 KCNQ1 AP2A1 GNAI2 KCNS3 COMT KCNB1 KCNK9 RIMS1 KCNG2 PPFIA4 CPLX1 PPFIA3 PPFIA2 PRKCB KCNK6 KCNK7 KCNK10 KCNK2 KCNK4 MYO6 KCNN3 RASGRF2 GIT1 CACNA2D1 CACNA1B CACNG3 SLITRK3 ALDH5A1 CHRNB2 SLITRK5 GLS2 GNB2 GNB1 NLGN3 NLGN4X;NLGN4Y HOMER1 GNB4 NRXN3 LRRTM3 LRRTM4 LRTOMT TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse CD3G HLA-DPB1-1 HLA-DPA1 PTPN22 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 NTHL1 TDG RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR PSEN2 APH1A ADAM17 PSENEN REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination RSPO1 ZNRF3 LGR6 FZD4 LGR5 FZD6 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A9 SLC13A1 SLC20A1 SLC12A6 SLC26A2 SLC4A3 SLC20A2 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors POLR2L CETP EEPD1 RARA H2BC15;H2BC3;H2BC11;H2BC12 YY1 APOC2 SCD FASN CAV2 PIK3R1 TNRC6A-1 FABP5 FABP6 S1PR3 EGFR MAPK1 AKT2 AKT3 APOC1 STRN AKT1 PTK2 APOE PCK1 MMP7 PTGES3-1 MMP9 SDR16C5 DHRS9 CRABP1 RDH14 ADH4 POLR2G KDM1B PPID GTF2F1 AREG SPHK1 HDAC1 MYB KDM3A GNB2 KDM1A SMC3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 GNB1 KDM4B STAG2 NRIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNB4 TFF1 GNAI2 FKBP4 JUN G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events PPP2R5D RGS8 PLCB4 GPR37L1 CENPS-CORT;CORT;CENPS TAS2R42 BDKRB2 NPBWR1 BDKRB1 GALR1 DRD4 NPBWR2 CDK5 OPN3 PPP1R1B PNOC GPSM1 RGS17 AHCYL1 GPER1 LPAR1 GRM8 LPAR2 GPSM3 LPAR3 PTGER3 CCL4L2;CCL4L1;CCL4 S1PR3 RGS22 S1PR2 LPAR5 PDE1A P2RY13 NMS GPR55 APLN TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 CAMKK2 MAPK1 C3AR1 NPY GNAZ OPN1SW CAMK4 TAS2R39 TAS2R7 TAS2R8 PSAP TAS2R1 TAS2R4 PRKACB-1 GABBR2 PRKAR1A PRKAR2A PPP3CB TAS1R1 GNAT2 TAS1R3 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 MCHR1 CAMK2B CAMK2D CAMK2A CAMK2G ADRA2A GNA14 CCL13;CCL2 GNB2 CXCL8 CCL20 GNB1 CXCL5;CXCL6 GNB4 GNAI2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME ADAL PCK1 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle TFDP1 E2F2 TFDP2 FZR1 UBE2C E2F3 ATRX CDC26 ANAPC1 ANAPC10 ANAPC11 CDK6 CCNE1 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT PPP2R5B PPP2R5A PPP2R5D PPP2R5C RBX1 H2BC15;H2BC3;H2BC11;H2BC12 SOX3 RSPO1 DACT1 ZNRF3 LGR6 FZD4 AXIN2 LGR5 WNT5A FZD6 WNT8A CSNK2B CSNK2A1;CSNK2A3 PSMD8 PSMA6 SFRP1 TRRAP MEN1 PSMD12 PSMD11 RUVBL1 PSMB1 CTNNB1 PSMC2-1 RNF146 PSMA7 AKT2 BTRC HDAC1 TCF7L1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 KREMEN1 DKK1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FRAT2 AKT1 CTBP1 PPP2R5E ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 CCNB2 NEK9 CCNB1 NEK6 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry TFDP1 TFDP2 FZR1 PSMD8 PSMA6 PSMD12 PTK6 PSMD11 LIN52 PSMB1 PSMC2-1 PSMA7 AKT2 AKT3 CCNA1 CCNE1 AKT1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers STIM1 BTK ORAI2 SH3KBP1 PLCG2 AHCYL1 PIK3R1 BLNK SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 PPP2R5E GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib SLC37A4 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO4C1 SLCO1C1 SLCO4A1 SLCO2B1 SLC16A2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis KLC2 RACGAP1 MFN1 KIF1C HMG20B MFN2 KIF21B L1CAM SH2B3 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 RBSN KIF27 KIF18A RHOA KIFC1 CAPZA1 MAFF CDK5 KIF2C CRK ZFPM2 DOCK1 ZFPM1 IGF2 CD9 NOS2 TRPC6 CFL1 PDE11A TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PDE10A PDE1A KCNMB1 KCNMB4 SLC7A7 SLC7A8 SLC7A11 CD84 RAP1A MAPK1 P2RX4 APOB MAPK14 MPIG6B PDPN AKT1 PIK3R5 PRKACB-1 PRKAR1A PRKAR2A PPIL2 CYB5R1 SPN SLC16A3 SELP CFD CD2 CD244 PLAU PLAT SERPINB8 SERPINB6-2 S100A10 PLCG2 ITGAV TGFB2 FGB FGA PF4;PF4V1-1 SERPINE2 F10 F12 F11 FGG TTN-1 F2 SMPD1 F9 GNAI2 PPP2R5E ANGPT4 ITPK1 PPP2R5B TEK PPP2R5A PPP2R5D PPP2R5C DAGLA DGKB LGALS3BP PECAM1 WDR1 OLA1 LEFTY2;LEFTY1 SYTL4 NHLRC2 ENDOD1 PRKCH CLEC3B DGKZ STIM1 APOH ORAI2 MANF ATP1B1 DGKK CALU PTGIR P2RY1 PIK3R1 PRKCB MGLL F2RL2 ACTN1 ATP1B3-1 JAML CD99 ANO6 LAMP2 PSAP ARRB1 PTK2 PLG SDC3 IGF1 APBB1IP EPCAM GPC3 MMP1 GPC2 GPC4 PIK3CG ITGAM ORM2;ORM1 PTPN11 CD63 KLKB1 P2RX7 APOA1 ADRA2A ATP2B2 ATP2B1 SLC8A1 HGF SLC8A2 DOCK7 FLNA CSK HDAC1 GNA14 MYB GNB2 KDM1A GNB1 KIF12 GATA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNB4 PHF21A AKAP1 CDC42 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R5E HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress TFDP1 TFDP2 E2F3 EPAS1 PTK6 CAPZA1 STAP2 CHD6 EIF2S2 EIF2S3;EIF2S3B ATP6V1H SOD2 LY96 TLR4 BACH1 UBE2D3;UBE2D2 TERF2IP SLC7A11 TERF2 MAPK1 MDM2-2 APOB CCNA1 RPL4 RPL30 RPL31 ACTR10 RPL6 HSPA4L RPL7 HSPA14 CCAR2 BAG3 HSPA12B RPL35 DNAJC2 RPL38 ATR DNAJC7 RPL39 RPL22 MLST8 DCSTAMP CREB3 CREB3L1 RPL29 RPA2 RPA3 LAMTOR2 PPP1R15A LONP1 PREB ASF1A NPRL2 WDR59 H1-3 H1-2 H1-5 HIF3A LIMD1 MINK1 DEPDC5 MAP4K4 CDKN2D NRIP1 CDKN2C CASTOR1 FKBP4 YIF1A CASTOR2 MAP3K5 SZT2 ERN1 AR KLHDC3 HMGA2 GPX7 TKT NR3C1 HM13 SH3BP4 DNAJA4 BMT2 RPL18 CSNK2B CSNK2A1;CSNK2A3 DYNC1I2 CYBB DCTN2 SYVN1 CYBA RPL37A-1 ACTR1A AKT1S1 BTRC DYNC1H1 AJUBA BAG2 RPL7A ME1 E2F2 DNAJA2 APOA1 ARNT NCOA6 SEC31A CXXC1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TXNRD1 CBX4 BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 GFPT1 DCTN1 SLC46A1 EZH2 MEF2C ATOX1 CHAC1 PSMD8 PSMA6 PSMD12 PSMD11 TALDO1 PSMB1 PSMC2-1 PSMA7 TRIB3 CDKN2B HSP90B1 DIS3 MAPK14 EXOSC6 EXOSC4 EXOSC9 EXOSC8 AKT1 DCP2-1 EXOSC2 EXOSC1 RBX1 CDK6 NUP205 NUP107 CAMK2B CAMK2D COX7C CAMK2A NUP85 CAMK2G NUP88 SEC13 NUP133 CRTC1 NQO1 PPP2R5B COX6C PALB2 PHB2 COX6A1 COX6A2 TCIRG1 G6PD ATP6V0D2 ATP6V1A HIGD1A TNRC6A-1 HSPA9 IDH1 FZR1 UBE2C CDKN2A CDC26 ATP6V1F ANAPC1 ANAPC10 ANAPC11 RPS15 AKT2 AKT3 RPS11 RPS13 CRTC3 RAI1 PTGES3-1 TGS1 MBTPS1 RPS25 RPS27 RPS29 FAU RPS21 RPS24 TRIM21 AREG CCNE1 CXCL8 JUN KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection POLR2L SNW1 WBP11 PRPF6 SUMO1 RTN3 PRPF8 H2BC15;H2BC3;H2BC11;H2BC12 CGAS ELAVL2 DYNLT1 BUD31 RPL18 FASN HNRNPA1-1 DHX38 PIK3R1 LY96 HNRNPA2B1 RIPK1 SNRPA1 TLR4 MAGT1 CTNNB1 MAPKAP1 PABPC1;PABPC3 HNRNPR PABPN1-1 CLDN1 EIF4E TYRO3 TMEM258 DAD1 GRPEL1 SNRPF KPNA4-1 RPN2 NRBP1 SDC3 RPN1 PQBP1 PIK3R4 MLST8 ISY1;ISY1-RAB43 SF3B6 GPC3 XAB2 NUDT21 GPC2 PHF5A MMP9 SNRPE-2 SNRPN GPC4 SNRPG-2 LY6E BAG2 CHERP EIF4G3 CTNNBL1 CAMK2B TSG101 CAMK2D CAMK2A PUF60 CAMK2G DNAJA2 PPIL4 POLR2G PDCD6IP APOA1 STT3B SRRM2 COG1 GTF2F1 CTR9 NMT1 SUGP1 UBA6 PCF11 F2 UBA7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AP2A1 MAPRE3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 AP2A2 TAOK1 PPIL1-1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN RIT2 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress PKN2 PTK2 FLT4 PRKACB-1 KDR ITGAV PECAM1 PRKAR1A PRKAR2A MLST8 CTNNB1 PPP2R2A;PPP2R2D MAPKAP1 GNB2 RAMP2 GNB1 P2RY2 TRPV4 GNB4 AKT1 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology HDAC1 CAMK4 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F10 F9 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism IARS1 RPL35 RPL38 RPL39 TXNRD1 SECISBP2 RPL22 RPL18 AIMP1 RPL29 GNMT RPL7A CBS;CBSL RPS25 RPS27 EEFSEC RPS29 SEPHS2 FAU RPS21 RPS24 INMT RPL37A-1 SEPSECS RPS15 RPS11 AHCY RPS13 RPL4 RPL30 RPL31 RPL6 RPL7 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS BDNF DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages AREG FGF7 LAMA2 LAMB2 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli PKN2 CACNA1H P2RX7 PTK2 FLT4 PRKACB-1 KDR ITGAV PECAM1 PRKAR1A PRKAR2A MLST8 CTNNB1 PPP2R2A;PPP2R2D MAPKAP1 GNB2 RAMP2 GNB1 P2RY2 TRPV4 GNB4 AKT1 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching POLA2 RFC3 RFC4 RFC2 POLD4 PCNA RFC1 RFC5 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling RIPK1 TRAF2 UBE2D3;UBE2D2 TNF TBK1 SPPL2B SPPL2A OTULIN SHARPIN MIB2 BIRC2 TNFRSF1A BIRC3 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex POLR2L GTF2H2C;GTF2H2C_2;GTF2H2 POLR2G GTF2H3 GTF2F1 ERCC3 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion PLXNA2 PLXNA1 CFL1 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly ADNP H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 AKT2 AKT3 CDC37 MATK ERBIN PTK6 EGFR RHOA PIK3R1 AKT1 MEMO1 GAB1 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6A-1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface PDZD11 ATOX1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) MYO7A RDH8 RDH12 DHRS9 RPE65 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 POLA2 TFDP1 TFDP2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes CSNK2B CSNK2A1;CSNK2A3 NCAPG CCNB2 CCNB1 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions BTK PLCG2 SIGLEC15 SIRPB1 PIK3R1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAF7L POLR2L GTF2H3 POLR2G TAF12 TAF13 TAF11 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 TAF7 TAF5 TAF2 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling CDC37 ERBIN ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway PPP2R5B TEK PPP2R5A PPP2R5D PPP2R5C RANBP9 SPTBN4 SPTB PHB RASGEF1A GDNF KIT IRS1 FRS2 PIK3R1 PSMD8 PSMA6 PPP1CC PSMD12 EGFR PSMD11 FLT3 PSMB1 PSMC2-1 RAP1A KLB PSMA7 MAP2K2;MAP2K1 MAPK1 JAK1 FGF19 GOLGA7-1 CSF2 TYK2 ARRB1 RBX1 PTK2 IL2RB APBB1IP MRAS CSF2RA MAP3K11 RASGRF2 LRRC7 IRS2 DAB2IP SPTAN1 RASAL3 IL2 SPRED3 SPRED2 SPRED1 RASA4;RASA4B NF1 DUSP10 PTPN11 CAMK2B KSR2 CAMK2D CAMK2A ZDHHC9 LAMTOR2 CAMK2G PTPN7 HGF ABHD17B RCE1 AREG FGB ABHD17C FGA CSK FGF7 FGF22 FGG PPP2R5E KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway NQO1 TXNRD1 RBX1 PALB2 TKT G6PD CHD6 ME1 CSNK2B IDH1 CSNK2A1;CSNK2A3 PSMD8 BACH1 PSMA6 PSMD12 PSMD11 SLC7A11 TRIM21 TALDO1 PSMB1 PSMC2-1 PSMA7 AREG AKT2 AKT3 BTRC AKT1 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells KLC2 RACGAP1 DYNC1I2 DCTN2 KIF18A CTSA CAPZA1 ACTR1A KIF2C CTSH CTSF HLA-DOA DCTN1 DYNC1H1 HLA-DPB1-1 ACTR10 HLA-DPA1 RAB7A REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NEUROD1 NKX2-2 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex CSNK1D CRY1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression POLR2L SAP130 GTF2H3 UBTF SAP30BP H2BC15;H2BC3;H2BC11;H2BC12 SAP30 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 HDAC1 TAF1D SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle STOM CSK NIPSNAP2 MTR-1 RAB7A ARHGDIG GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation SNW1 MAMLD1 SMAD4 PAX8 LHX1 FOXA2 PSMD8 PSMA6 EPHA4 PSMD12 PSMD11 TEAD2 RIPPLY2 TEAD4 MSGN1 PSMB1 CTNNB1 PSMC2-1 NANOG;NANOGP8 PSMA7 DLL3 TCF7L1 ZIC1 SNAI1 MYB POU5F1;POU5F1B DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLC5A1-1 ARL2BP SLC27A6 SLC29A4 SLC28A2 SLC29A3 SLC44A2 SLC40A1 SLC17A8 HEPH SLC35B3 SLC9A2 SLC9A3 EMB SLC9A4 PDZD11 SLC27A1 SLC7A7 SLC7A8 SLC7A11 SLC8B1 RSC1A1 SLC4A3 SLC38A3 SLC2A4 SLC5A6 SLC10A6 SLC26A2 SLCO4C1 SLC35D2 SLC9A1 SLC6A5 SLC6A2 SLC35A1 SLC30A3 SLC30A2 SLC39A5 SLC16A3 SLCO1C1 SLC25A26 SLCO4A1 SLC47A1 SLCO2B1 SLC16A2 SLC13A5 SLC26A9 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC5A4 SLC13A1 SLC2A12 SLC20A1 SLC12A6 SLC31A1 SLC25A18 SLC8A1 SLC8A2 SLC25A10 SLC22A12 SLC22A18 SLC20A2 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling EPHA5 MYH10 PSEN2 ARPC4 PTK2 EPHA4 APH1A RHOA PSENEN ACTR3-1 MYH9 MMP9 GIT1 ACTR2 AP2A1 AP2A2 EPHB1 CFL1 EPHB4 CDC42 EPHB3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation TTC5 MDM2-2 SETD9 JMY PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE1 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins DAD1 RPN2 RPN1 H2BC15;H2BC3;H2BC11;H2BC12 GANAB EPS15 MPHOSPH8 FOXA2 EZH2 TNRC6A-1 CSNK2B TWIST2 CSNK2A1;CSNK2A3 PSMD8 PSMA6 PSMD12 PSMD11 PCSK7 PSMB1 CTNNB1 PSMC2-1 PSMA7 MAPK1 STRAP MDM2-2 HDAC1 ZMYM2 BANP SNAI1 MCRIP1 KDM1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ZBTB33 RBBP7 FOXP2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PKM KLF9 CTBP1 TMEM258 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA NUP85 RCC1 NUP88 SEC13 NUP133 NUP205 NUP107 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) SC5D LBR TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 TFDP1 E2F6 TFDP2 PCGF2 EZH2 RYBP MGA RBBP8 BMI1 PHC3 RBBP7 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling TRPC6 DCC UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A BTRC PSMD8 PSMA6 RBX1 PSMD12 MAPK14 PSMD11 PSMB1 PSMC2-1 PSMA7 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development HDAC1 CAMK4 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm SNW1 PSMD8 PSMA6 MAMLD1 EPHA4 PSMD12 PSMD11 RIPPLY2 MSGN1 PSMB1 CTNNB1 PSMC2-1 PSMA7 DLL3 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins PRSS41 FBXL19 OTOA KLHL2 FBXL16 XPNPEP2 RTN4RL1 FBXL14 ST3GAL6 LY6D KLHL20 PIGK SPSB2 SPSB1 LY6G6C CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EPAS1 PIGG ASB7 TECTA;TBCEL-TECTA GPLD1 RHOA SRP68 SRP9 GOLGA2 GALNT14 GALNT9;GALNT17 GALNT16 GALNT15 GCNT1 GALNT10 POFUT2 MYO5A GALNT9 B3GNT6 POMK EIF5B RIPK1 TRAF2 CDC34 UBE2D3;UBE2D2 NUDT14 ASCC2 TGFBR1-1 RNF146 FCSK DOLPP1 GMPPA MTRF1L COG8 GNE APOB COG6 CCNA1 RPL4 RAB36 COG2 RPL30 BET1L RPL31 EIF4E EIF4B RPL6 RPL7 RPL35 RPL38 RPL39 RPL22 OTULIN UQCRC2 RPL29 EXOC7 RAB11A TCF25 USP10 USP15 TIMM17A-1 APH1A OGDH TMED7 PSENEN TMED9 KDELR2 METTL22 KIN FAM86B1;EEF2KMT;FAM86B2 EEF1AKMT2 EEF1AKMT1 TRMT112 SMC3 STAG2 PSMD10 NRIP1 PSMD9 POMP ARG2 USP37 COPS7B WDR20 XPC USP24 COPS7A USP25 USP20 USP44 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RAD23A USP28 PTRH2 RAD23B DDB1 COPS8 GSPT1 RPL18 ETF1 CALU EIF3C;EIF3CL MDH2 EIF3L EIF4EBP1 EIF3E EIF3B EDEM3 MIA2 RNF103 RNF139 TRIM13 SYVN1 AGBL5 TTLL6 RPL37A-1 UGGT2 TTLL5 UGGT1 AGTPBP1 AGBL1 VASH2 VASH1 IL33 CTBP1 LY6E RPL7A APOA2 APOA1 APOA4 ALG8 ADRA2A ALG3 COG1 CTR9 SEC31A ST6GALNAC5 PRSS23 IGFBP6 CCN1 IGFBP5 NDUFB6 IGFBP4 MXRA8 VWA1 FAM20A HSD17B10 IARS1 DHDDS RAB2B RAB25 RAB17 MSRA RAB14 FOLR2 DCTN1 MRPS17 MRPS16 MRPS33 MRPL18 MRPL19 MRPS31 MRPL39 MRPL58 MRPL37 MRPL34 MRPL11 CHCHD1 MRPS28 PTCD3 TSFM MRPS23 MRPL49 MRPS2 MRPL47 MRPS7 MRPL43 MRPL21 PPA2 LOC107987373;MRPL23 MRPL52 VDAC1 HSP90B1 PRKDC PEX12 RNF40 RNF144A TMEM129 RNF152 NEU3 ARSJ NEU1 ARSH ARSI APOE B4GALNT2 CTSA AIMP1 RAB1B GGA3 INS;INS-IGF2 TRAPPC4 TRAPPC10 RAB27A FFAR1 RAB11B TRAPPC6A TRAPPC6B RAB13 RAB38 B3GNT2 PPA1-1 MITF CLSPN GRP P2RY2 HSPA9 IDH2 CDX2 GIP DRG1 DPH5 DPH6 ZC3H15 CPB2 POLB CPA3 ERO1B ENPEP CPB1 ACE NDUFS3 IGF1 INHBC CLTRN ANPEP B4GALT6 CPE TOP2B SMC6 NOP58 NSMCE1 NSMCE4A MBTPS1 CDH2 GARS1 FARSA YARS1 TARS1 VARS1 AREG UBE2T EEF1G TWNK CAPZA1 IGF2 EIF2B4 EIF2S2 EIF2S3;EIF2S3B EIF2B1 SEC61A2 SEC22B RAB7A USP7 CTSH MDM2-2 NPM1-2 BARD1 ACTR10 PRELID1 VDAC3 ING2 ANK1 RABGGTA PCNA MAN1A1 WRN PML TRRAP KDM1B DCAF13 RUVBL1 LONP1 PREB HIF3A USP22 AR PIAS3 SUMO1 VDR RARA NR3C1 CKAP4 KTN1 DCUN1D3 DDA1 ANKRD9 NAE1 DCAF10 WSB2 CSNK2B DCAF4;DCAF4L2;DCAF4L1 COMMD4 CSNK2A1;CSNK2A3 NEURL2 CCDC22 OBSL1 DYNC1I2 DCTN2 ACTR1A TUBA1A BTRC STAM2 DYNC1H1 CSNK1D APCS ODAM NAT8-2 SORL1 TSPAN33 TSPAN15 ITM2B PLG ADAMTS1 CTSG CMA1 MMP1 SPTAN1 SENP1 MEN1 HCFC1 HDAC1 ANKRD28 PPP6C USP9X SEC23IP GORASP1 LMAN2 TDG SEC22C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RAB9A ANK2 MCRS1 SPTBN4 CBX4 SATB1 SPTB BMI1 PHC3 H2BC15;H2BC3;H2BC11;H2BC12 YY1 NAGK AMDHD2 GFPT1 RENBP BIRC2 BIRC3 AXIN2 LAMB2 MGAT3 BPIFB2 FBN1 PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 CTNNB1 PSMC2-1 PSMA7 SATB2 PCGF2 PABPC1;PABPC3 RBX1 SLC35A1 SLC35A4 FKRP CRPPA LARGE2 SMAD4 FKTN NUP205 NUP107 NUP85 NUP88 SEC13 NUP133 XRCC4 OTUD5 ZRANB1 OTUB1 FGA F10 FGG F2 F9 SEMA5A DDX58 MUC5B CFP THBS2 THSD4 ADAMTS10 ADAMTS20 MUC1 ADAMTSL5 THSD7A MUC4 MUC21 SPG7 PALB2 UBE2C MGAT4A-1 MAGT1 RPS15 RPS11 RPS13 ST6GAL1 RIPK2 USP14 SFTPD RAB3D TUFM TMEM258 RAB37 DAD1 RAB5C ARRB1 ST6GALNAC3 RPN2 RPN1 NOD1 GANAB CSF2RA MGAT5 ST3GAL4 GPC3 ST3GAL1 ST3GAL3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E EDEM2 COP1 RPS25 RPS27 RPS29 MGAT4B FAU FBXO21 STT3B RPS21 HERC2 RPS24 FBXO7 FBXW8 KCTD7 RCE1 FBXW4 TUBB2B;TUBB2A UBE2R2 AARS2 TUBAL3 SPHK1 PARS2 UBA6 YARS2 GNA14 EARS2 RCHY1 AP3M1 CCNE1 ASB16 WARS2 LIPT1 GNB2 PIGS FBXL20 XRN2 TECTB KIF13A BTBD1 NRN1 GNB1 PDCL RTN4RL2 IZUMO1R GNB4 MSLN CCT7 UBE2B KLHL25 ALPG;ALPP;ALPI-1 PIGV TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 TWIST2 AR MSX2 PSMD8 UCMA RBX1 PSMA6 PSMD12 PSMD11 NR3C1 ESRRA PSMB1 PSMC2-1 MAF SATB2 PSMA7 CCNB1 MAPK1 SMAD4 AKT2 AKT3 RBM14 AKT1 PPARGC1B CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress NQO1 TXNRD1 COX6C RBX1 GPX7 PTK6 PALB2 TKT HM13 STAP2 COX6A1 COX6A2 G6PD CHD6 TGS1 ME1 ATOX1 SOD2 COX7C CSNK2B IDH1 CSNK2A1;CSNK2A3 PSMD8 BACH1 PSMA6 PSMD12 PSMD11 SLC7A11 TRIM21 NCOA6 TALDO1 CYBB CYBA PSMB1 PSMC2-1 PSMA7 AREG AKT2 AKT3 BTRC AKT1 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling JAK1 IFNL2;IFNL3;IFNL1 IL10RB IFNLR1 IL19 PTPN11 TYK2 IL20RA AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles PSIP1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly NUP85 SNRPF NUP88 SEC13 SNUPN NUP133 DDX20 GEMIN2 SNRPE-2 SNRPG-2 TGS1 NUP205 NUP107 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6A-1 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors F12 F11 F9 KLKB1 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling IL18R1 IL13 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins ADAMTS20 ADAMTSL5 THSD7A POFUT2 SEMA5A ADAMTS1 CFP THBS2 THSD4 ADAMTS10 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations ATRX REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 PSMA7 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG CRLS1 PLA2G3 LPCAT4 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR2L POLR3A POLR3D POLR3F GTF3C2 POLR3K GTF3A INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion ANO6 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network PPP2R5B PPP2R5A PPP2R5D PIP4K2C PPP2R5C IRAK1 IRS2 KIT PIK3CG IRS1 FRS2 PTPN11 PIK3R1 INS;INS-IGF2 BDNF EGFR FLT3 HGF KLB GAB1 AREG MAPK1 IER3 AKT2 PHLPP1 AKT3 FGF7 IL33 TRIB3 FGF22 FGF19 STRN MYD88 PIK3R5 AKT1 PPP2R5E PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation PTK6 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation RPS27 RPL35 RPS29 RPL38 RPL39 FAU RPS21 RPS24 RPL22 RPL37A-1 RPS15 RPL18 RPS11 RPS13 RPL4 RPL30 RPL29 RPL31 RPL7A RPL6 RPL7 RPS25 KINESINS%REACTOME%R-HSA-983189.5 Kinesins KLC2 RACGAP1 KIF1C KIF21B KIF27 KIF18A KIFC1 KIF12 KIF2C NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes NQO1 TXNRD1 CHD6 BACH1 SLC7A11 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R PIK3R4 IGF1 FLT3 KLB GAB1 IRS2 AKT2 FGF7 TRIB3 IGF2 FGF22 FGF19 PDE3B IRS1 PTPN11 FRS2 PIK3R1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations SULT4A1 ARNT2 GSTK1 COMT AKR7A3 PTGES3-1 GGT1 CYP2S1 FMO2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MAT2A ACSM5 DPEP1 GSTA3;GSTA5;GSTA1;GSTA2 ACSM4 GLYAT MTR-1 BPNT1 UGT2A1 CHAC1 ADH4 CYP2D6;LOC107987479;LOC107987478-1 CYP11B1;CYP11B2 EPHX1 GLYATL3 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ARNT ABHD10 CYP7B1 CYP39A1 POR PODXL2 AHCY OPLAH CES2 TRMT112 MAOA MTARC1 MGST3 SLC35D2 MGST1 GSTT1 CYP7A1 AS3MT NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMD8 PSMA6 RBX1 PSMD12 PSMD11 PSMB1 AKT1 PSMC2-1 PSMA7 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC CSNK2B CHPT1 CHKB CSNK2A1;CSNK2A3 LPIN1 STARD10 SLC44A2 ABHD3-2 PHOSPHO1 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival PLCG2 PRKACB-1 PRKAR1A MYH9 PRKAR2A GGT1 GNAZ CD3G AHCYL1 CYSLTR1 ADAM17 GNB2 MAPK14 DPEP1 GNB1 GNB4 GNAI2 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta RIPK1 TRAF2 UBE2D3;UBE2D2 ITCH OTUD5 DHX58 TBK1 NKIRAS1 UBA7 NKIRAS2 DDX58 ATG5 PIN1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints PSMD8 RBX1 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 ZNF385A PSMA7 MDM2-2 BTRC PCBP4 CCNA1 CCNE1 MAPK14 COP1 PHF20 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade PDE6B PDE6A GNB1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint PSMD8 PSMA6 PSMD12 PSMD11 PSMB1 PSMC2-1 ZNF385A PSMA7 MDM2-2 PCBP4 CCNA1 CCNE1 COP1 PHF20 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 GNA14 GNB2 MAPK14 GNB1 P2RY1 GNB4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol ABCD3 SLC27A5 CYP39A1 AMACR LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy PRKAG2 PLIN2 PRKAG3 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS CSPG5 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation GABRR3 GABRR2 GABRR1 KCNJ3 KCNJ5 GABBR2 KCNJ10 GABRA4 KCNJ15 GNB2 GNB1 GABRB3 GNB4 GNAI2 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) TBK1 TLR4 PTPN11 LY96 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription SNW1 HDAC1 HDAC5 HES5 CCNC-1 MAMLD1 RBX1 CDK8 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes CDK12 POLR2L ATR GTF2H3 POLR2G SSRP1 GTF2F1 ERCC3 GTF2H2C;GTF2H2C_2;GTF2H2 FANCI FANCC JUN ELL IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors GRIK5 GRIK4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS27 RPS29 FAU RPS21 RPS24 RPS15 EIF3C;EIF3CL RPS11 EIF3L RPS13 EIF2S2 EIF3E EIF2S3;EIF2S3B EIF3B RPS25 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer PPP2R5B PPP2R5A PPP2R5D PPP2R5C FZD4 KREMEN1 DKK1 FZD6 CTNNB1 CTBP1 PPP2R5E G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels GNB2 KCNJ3 KCNJ5 GABBR2 KCNJ10 GNB1 GNB4 KCNJ15 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 CCNA1 PSMD8 PSMA6 CCNE1 PSMD12 PTK6 PSMD11 PSMB1 PSMC2-1 PSMA7 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB37 RAB5C RAB2B RAB25 RAB27A RAB17 RAB11B RAB13 RAB14 RAB38 RABGGTA RAB36 RAB1B RAB3D RAB7A RAB11A RAB9A COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade MASP1 CRP COLEC10 C1QB C3AR1 CPB2 CR2 C7 C1R C9 C1QC F2 CPN1 CFD CFB SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R5E DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP2D6;LOC107987479;LOC107987478-1 CYP2S1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation RPS27 RPS29 FAU RPS21 RPS24 RPS15 EIF3C;EIF3CL RPS11 EIF3L RPS13 PABPC1;PABPC3 EIF2S2 EIF3E EIF2S3;EIF2S3B EIF3B EIF4E EIF4B RPS25 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells INS;INS-IGF2 AKT2 PDX1 AKT3 MAFA NEUROD1 FOXA2 NKX2-2 GCK AKT1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease FGFR3 FRS2 PIK3R1 GAB1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis ATR TERF2IP TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SMC3 SUN1 STAG2 REC8 SMC1B STAG3 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ MAPK1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNB2 GNB1 GNB4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding FSHR TSHR GPHB5 DRD4 DRD5 CCL3L1;CCL3L3;CCL3;CCL18 TAS2R3-1 TAS2R16 PRH1-TAS2R14;TAS2R14-3 TAS2R40 TAS2R41 C3AR1 NPY TAS2R39 TAS2R7 TAS2R8 TAS2R1 TAS2R4 GABBR2 SMO TAS1R1 TAS1R3 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 MCHR1 FFAR1 F2 RAMP2 HTR6 HTR1A TAAR5 SCT RXFP1 GPR37L1 KEL CHRM5 CENPS-CORT;CORT;CENPS TAS2R42 MLN GIPR GPRC6A NPBWR1 BDKRB2 GALR1 BDKRB1 NPBWR2 PROK1 WNT10B OPN3 LTB4R2 PNOC GRP LPAR1 GPER1 LPAR2 GRM8 LPAR3 LPAR4 PTGIR GPR35 PROKR1 GLP2R P2RY2 RAMP3 P2RY1 TAC3 PTGER2 OPN4 PTGER3 NMB WNT8A P2RY11 XCL1;XCL2 S1PR3 CCK LPAR5 S1PR2 NMS P2RY13 GPR55 FFAR3;GPR42 WNT7A F2RL2 APLN GIP ACKR1 RAMP1 CYSLTR1 OPN1SW PSAP FZD4 FZD7 WNT5A FZD6 ADRA2A CCL13;CCL2 GNB2 CCL22 CXCL8 AVPR1B GNB1 CCL20 ACKR4 CXCL5;CXCL6 GNB4 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis NDST3 GPC3 HS3ST2 GPC2 GPC4 SDC3 GLCE SLC35D2 HS6ST2 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation LBR EMD LEMD3 CCNB2 CCNB1 PPP2R2A;PPP2R2D WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking WNT10B TMED5 WNT7A VPS26A WNT5B WNT5A WNT8A ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection ARPC4 PTK2 WAS ACTR3-1 MYH9 CRK DOCK1 MAPK1 BTK WASF2 MYO10 CD3G WASF3 MYO5A ACTR2 ABI2 WIPF3 CDC42 NCKAP1L DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis PLCG2 CD3G AHCYL1 PIK3R1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDKN2A GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F10 F2 F9 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones DIO1 TPH1 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases SOD2 CDK5 GOLGA2 JUN SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 FGF22 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis POLR2L AJUBA CNOT9 POLR2G RARA NCOA6 H2BC15;H2BC3;H2BC11;H2BC12 HOXA3 HOXB3 HOXB2 YY1 HOXB1 HOXA2 PCGF2 HOXB4 EZH2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 CNOT6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JUN DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade PPP2R5D UBE2V1 NOD1 IRAK1 S100A1 MEF2C MAP3K8 LY96 TRAF2 TLR4 S100A9 TAB2 MAP2K2;MAP2K1 MAPK1 FGB FGA BTK BTRC ECSIT RIPK2 FGG USP14 MAPK14 NKIRAS1 NKIRAS2 PELI1 MYD88 JUN INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling IL2 JAK1 IL2RB CSF2 PIK3R1 CSF2RA TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 NUP88 SEC13 NUP133 EIF4E NUP205 NUP107 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions COL18A1 LAMA2 ITGAV ITGB4 LAMB2 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260910%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism BCKDHA ACAD8 MCCC2 ECHS1 HIBADH MCCC1 BCKDHB HSD17B10 ACADSB ACSF3 ACAT1 ALDH6A1 PCCA AUH IVD PCCB DBT MMUT MLYCD BCAT1 HMGCLL1 DLD HIBCH BCAT2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260910%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 FOSL1 CCND1 MYC NRIP1 ERBB2 PGR VIM TIMP1 STAT5A EGF FN1 ESR1 AREG OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260910%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS BMP4 BMP2 MAG IL1B PLP1 CNTF CNP PDGFB ASCL1 FGF2 TNF GLI2 SHH SOX8 MBP SOX9 SOX6 SOX5 NKX2-2 NKX2-6 MOG OMG LIF CXCL2;CXCL3;CXCL1-1 OLIG1 IGF1 OLIG2 MYT1 SOX10 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260910%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT LMNA ZMPSTE24 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260910%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis FADD TICAM1 TNFRSF1A MAPK8 FTL-1 CASP8 RIPK3 PARP1 TRADD TNF PLA2G4A RIPK1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260910%WP100%HOMO SAPIENS Glutathione metabolism GSTA3;GSTA5;GSTA1;GSTA2 GCLM GGT1 GGT5 G6PD GPX1 GPX4 IDH1 GSS GSR GSTT2B;GSTT2 OPLAH GSTM1;GSTM2-1 GSTA3;GSTA1 GCLC ANPEP WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260910%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis CCND1 FZD1 NEUROD1 FZD3 WNT3A WNT5A WNT7A PROX1 NEUROG2 WNT3 LRP6 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260910%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT2 AKT3 AKT1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260910%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 ACE AGTR1 AGTR2 IL6 SIGNALING%WIKIPATHWAYS_20260910%WP364%HOMO SAPIENS IL6 signaling JAK2 IL6R MAP3K7 JUNB MAPK3 JAK1 NCOA1 MAP2K4 CREBBP STAT1 BAD PRKCD STAT3 GAB1 PTPN11 TYK2 AGT VAV1 NR2F6 HCK IL6 RPS6KB1 IRF1 GRB2 VIP IL6ST SOS1 BCL2L1 SHC1-1 TIMP1 AKT1 CRP GSK3B HDAC1 PIK3R2 PIK3R1 PRDM1 NLK SOCS3 MAP2K2;MAP2K1 MAPK1 RAC1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260910%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL18 TMPRSS2 FURIN IL2 IL1B GFAP IL4 IL1A IFNG HMGB1-1 TLR8 IL12A TLR7 TLR4 TNF TLR3 ACE2 IL6 IL10 CCL11 MAPK1 CXCL8 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases DLL1 DLL3 DLL4 MAPK9 WNT11 MAPK7 HES3 MAPK6 HES2 MAPK4 WNT7B MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 CTNNB1 FGF2 GLI2 SOX9 BMP4 BMP2 MAPK8 FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 PIK3R2 PIK3R1 MAPK1 MAPK3 STAT1 PRKCD IHH FZD10 RBPJ FGF1 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PRKCG HES6 PRKCI PRKCH WNT5B PRKCB PRKCE PRKCA RUNX2 SMO PRKCQ PRKD1 NOTCH2 NOTCH3 NOTCH1 PRKDC NOTCH4 PIK3R4 PIK3R3 PRKCZ PIK3R6 PIK3R5 WNT6 WNT1 WNT2 WNT4 JAG2 WNT10B SMAD1 WNT10A SMAD4 FZD2 JAG1 FZD5 FZD4 FZD7 PTCH1 FZD6 FZD9 SMAD9 FZD8 SMAD5 FGF18 FGFR4 BMPR1B FGFR3 FGFR2 BMPR1A FGF10 FGFR1 WNT2B BMPR2 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG GLI3 PIK3C2B HEY1 HEY2 WNT9B WNT9A WNT16 PIK3CA MYOD1 PPARG PIK3C3 LRP5 WNT8A WNT8B MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response RB1 CDKN1A CDKN1B MRE11 HUS1B BRCA1 BBC3 CASP9 PIDD1 CCND3 CCND2 CHEK2 CASP3 SESN1 CHEK1 TLK2 CCND1 TLK1 MYC NBN APAF1 RFC1 SMC1A CDC25C CDC25A DDB2 CREB1 CCNE2 RRM2B FANCD2 CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 MDM2-2 CYCS-1 CCNB3 CCNB2 CCNB1 ABL1 E2F1 PMAIP1 SFN BID ATRIP GADD45B GADD45A RPA2 PML GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 CCNG1 PRKDC CDK1 RAD17 CASP8 FAS BAX RAD1 ATM ATR RAD9A FOXA2 PATHWAY%WIKIPATHWAYS_20260910%WP5066%HOMO SAPIENS FOXA2 pathway GSTA3;GSTA5;GSTA1;GSTA2 FOXA2 ABCC3 FOXA1 SREBF1 ABCC4 ABCC2 IRS1 MTTP IRS2 FOXO1-1 ACACA INS;INS-IGF2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 GSTM1;GSTM2-1 FASN GSTA3;GSTA1 APOB SLC27A5 PPARGC1B 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome MTMR10 KLF13 OTUD7A CHRNA7;CHRFAM7A GPR75 TRPM1 KAT2B CREBBP GRM6 CCL5 SERPINH1 FYN FANCD2 FAN1 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260910%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment CXCL10 TRAF6 IL2RA IL2RB PDCD1 STAT3 IL4 CCL5 TLR8 TLR7 TLR4 CD86 CD274 CCL13;CCL2 CD80 IL2RG SOCS1 CTLA4 STAT6 PIAS3 TGFB2 IL4R TGFB1 TGFB3 IRAK4 NFKB1 NFKB2 TGFBR2 LUNG FIBROSIS%WIKIPATHWAYS_20260910%WP3624%HOMO SAPIENS Lung fibrosis CSF3 CSF2 SERPINA1 FAM13A MECP2 MT2A CYSLTR2 PLAU IL12B CCN2 CCR3 CCR2 DSP EDN1 HGF ELMOD2 IL6 SFTPC MMP2 IL13 ATP11A MMP9 GREM1 CCL3L1;CCL3L3;CCL3;CCL18 CALCA EGF CEBPB RTEL1 CCL11 CXCL8 PARN PDGFA TGFA CCL4L2;CCL4L1;CCL4 TERT DPP9 SPP1 IL4 HMOX1 TIMP1 SKIL STN1 CMA1 PDGFB MUC5B BMP7 FGF2 SMAD7 TNF IL5 PTX3 NFE2L2 FGF1 FGF7 CXCL2;CXCL3;CXCL1-1 IGF1 IL1B CCL5 CCL13;CCL2 TGFB1 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260910%WP5088%HOMO SAPIENS Prostaglandin signaling CXCL10 IL1B CCR2 IL6 MMP9 CCL3L1;CCL3L3;CCL3;CCL18 CXCL8 AREG IL1A IFNG IL12A TNF PTGER4 CCL13;CCL2 CXCL9 PIK3CG CSF1 PTGER2 AHR PYCARD CASP1 NLRP3 VEGFA IRF7 TGFB1 CXCL2;CXCL3;CXCL1-1 CD28 IL17F KLRD1 NFKB1 PTGES IL17A PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260910%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER3 ALOX15 ADCY3 ALOX12 LTC4S GNAI1 PTGS1 CYSLTR1 NRAS ALOX5 LTA4H PTGDS HRAS PTGIS IGFBP5 PLA2G4A ALOX15B MAPK11 SIRT1 RB1 GNAS-1 CDKN1A GNAQ PRXL2B ALOX5AP TBXAS1 KRAS PTGS2-2 TP53 PTGER4 PTGER2 PTGES PTGER1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260910%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein WDR19 IFT122 IFT80 WDR35 HSPB11 DYNC2LI1 DYNC1LI1 DYNC1LI2 IFT22 IFT43 IFT81 IFT27 DYNLRB2 DYNLRB1 IFT46 DYNC1I1 DYNC2H1 DYNC2I2 DYNC1H1 DYNC1I2 DYNC2I1 DYNLT1 IFT140 DYNLT2B NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260910%WP5572%HOMO SAPIENS Nucleosome remodeling complex H4C6 ASF1A MCM2 ASF1B PRKDC NASP-1 SUPT16H XRCC6 DAXX PCNA XRCC5 H4-16 NAP1L1 SSRP1 IPO4 CHAF1B CHAF1A RBBP4 CHEK2 HAT1 SMIM40 H4C1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5049%HOMO SAPIENS Glycolysis in senescence RB1 LDHA G6PD GAPDH-1 PRKAA1 PKM PGK1 ALDOC ENO1 HK1 TP53 IL4 SIGNALING%WIKIPATHWAYS_20260910%WP395%HOMO SAPIENS IL4 signaling JAK2 MAPK3 JAK1 STAT1 BAD MAPK14 ATF2 STAT3 ELK1 IKBKB PTPN11 EP300 TYK2 MAPK11 JAK3 CHUK GAB2 FOS DOK2 CEBPA RPS6KB1 CBL RELA GRB2 INPP5D FLNA SOS1 SOCS5 STAT5A STAT5B NFKBIA SHC1-1 CEBPB FES PTPN6 IL4 IRS1 IRS2 PIK3CD AKT1 IL2RG SOCS1 STAT6 PIK3R2 IL4R PIK3CA PIK3R1 SOCS3 NFKB1 MAPK1 MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260910%WP5236%HOMO SAPIENS Markers of kidney cell lineage CITED1 EPO TNC SIX1 TCF21 SALL1 HNF4A SIX2 KDR RSPO3 RSPO1 DACT1 PDGFRB BMP7 EMX2 FOXD1 OSR1 KCTD1 HNF1B HNF1A AXIN2 DCN PAX2 ACTA2 FGF7 SFRP1 FGF8 ALDH1A2 KIT PECAM1 TSHZ3 NTN1 NT5E EGLN1 EGLN3 EGLN2 EYA1 BMP4 AP2B1 TBX18 PBX1 DES NOTCH2 NPHS1 GDNF NOTCH1 NPHS2 WT1 LHX1 TLX1 REN FAT4 VSX2 WNT4 SMAD1 JAG1 SMAD5 WNT5A LIDOCAINE METABOLISM%WIKIPATHWAYS_20260910%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260910%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAPK9 JUNB MAPK3 MAP2K4 MAPK8 MAPK14 ATF2 MAPK12 MAPK13 MAPK10 MAPK11 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K9 FOS MAP2K7 EIF4E MAP3K4 MAP2K6 MAP2K3 JUN MAP3K1 BST2 DDIT3 BCL2 IFITM3;IFITM2;IFITM1 MAP3K10 RAF1 MAP3K11 MAP2K2;MAP2K1 MAPK1 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260910%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GPX4 GSS GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 TPMT CYP46A1 COMT HNMT HS6ST1 HS6ST2 HS6ST3 NAA80 NDST2 NDST1 AKR7A2 AKR7A3 NDST4 NDST3 CYP1B1 GSTK1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP39A1 SULT2B1 CYP27A1 CYP2U1 CYP2E1 SULT6B1 SULT2A1-4 NNMT HS3ST3A1 GSTCD MGST3 MGST1 MGST2 GLYAT CYP4F22 CYP19A1 CYP27B1 CYP4X1 CYP2B6 CHST11 CHST12 CYP11A1 CHST10 CHST13 CHST14 GSTM4 GSTM3 EPHX2 EPHX1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP26A1 CYP27C1 CYP2S1 CYP1A1 NAT9 GAL3ST1 NAT10 AKR1B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 NAT14 HS2ST1 SULT1C3 SULT1C2 CYP26B1 AKR1B15;AKR1B10 CYP4V2 CYP2R1 UGT2A1 SULT4A1 GAL3ST3 GAL3ST4 HS3ST3B1 CHST8 CHST9 CYP2D6;LOC107987479;LOC107987478-1 CHST6 NAA30 CHST7 GSTO2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 GSTO1 GPX5 AKR1A1 KCNAB1 KCNAB2 CYP7B1 KCNAB3 BAAT INMT NAA40-2 CYP21A2 CHST1 CHST4 NAT8L CHST2 CHST3 CYP2J2-1 NAA20 GSTP1 AKR1D1 CYP2C18-1 CYP7A1 CYP17A1 NAA50-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2F1 CYP51A1 NAT8-2 FMO1 CYP4B1 FMO2 HS3ST5 HS3ST6 FMO3 FMO4 HS3ST4 CYP8B1 FMO5 HS3ST1 SULT1B1-1 HS3ST2 GSTZ1 CYP2W1 CYP24A1 GSTA4 CYP11B1;CYP11B2 CYP20A1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260910%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB3 ITGB2 ILK ITGAE ITGAL MYPN MAPK7 ITGAX RAC3 MAPK6 ITGB8 ITGAV MAPK4 ITGB7 ITGB6 VAV3 MAPK12 ITGA4 PDPK1 MAPK10 ITGA3 ITGA2 ITGA1 VAV2 ITGAD ITGA8 RAPGEF1 ITGA7 ITGA6 ITGA5 ARHGEF7 CRK DOCK1 ITGA9 ROCK1 ROCK2 SRC CDC42 PAK1 RHO CSK PAK3 PAK2 PAK4 GIT2 SORBS1 CAPN11 CAPN10 ZYX BCAR1 MAP2K6 MAP2K3 RAF1 FYN AKT2 AKT3 AKT1 PIK3R2 MAP2K2;MAP2K1 MAPK1 RAC1 GRB2 SOS1 SHC1-1 HRAS MYLK2 BUB1B-PAK6;PAK6 ITGA2B ARAF CAPN9 CAPNS1 CAPN6 CAPN7 CAPN5 CAPN2 CAPN3 CAPN1 TNS1 SELENOP TLN1 VCL SHC3 PXN RAP1B RAP1A MAP2K5 VASP CAV3 CAV2 CAV1 BRAF PTK2 ITGA10 ITGA11 ITGB1 ITGAM ITGB5 ITGB4 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260910%WP530%HOMO SAPIENS Cytokines and inflammatory response IL1B CSF3 CSF2 IL12B IL6 IL13 IL10 PDGFA IL2 IL4 IL1A IFNG TNF IL11 IL5 IFNB1-4 IL15 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IL3 CSF1 CD4 IL7 HLA-DRA TGFB1 CXCL2;CXCL3;CXCL1-1 FELBAMATE METABOLISM%WIKIPATHWAYS_20260910%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260910%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IDO1 IL1B IFNG TNF IFNB1-4 AHR IL6 DDC GOT2-1 AADAT HAAO KMO TDO2 KYNU AFMID KYAT3 KYAT1 IDO2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260910%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming FTO ANKRD13C DNMT1 HDAC2 GGT6 CADM1 YTHDF3 CREBBP DNMT3A TET2 NOL9 PIP4K2A EZH2 EP300 IRS1 HDAC1 IFITM3;IFITM2;IFITM1 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260910%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders H4C6 WWTR1 YES1 SRRT SOX11 SOX12 POU3F1 POU3F2 FGF4 UTF1 SOX2 H4-16 SOX15 ZSCAN10 TEAD2 SOX4 H4C1 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260910%WP727%HOMO SAPIENS Monoamine transport and regulation ITGB3 IL1B MAPK14 AGT ACHE TPH2 TGFB1I1 PPP2CB;PPP2CA TNFRSF11B DBH SLC6A1 SLC6A2 SLC6A3 SLC6A4 HRH3 NOS1 UNC13B CDC25C IL1R1 TSC2 FBXO32 SYN1 SCAMP2 RBL2 TNF SLC5A7 ADORA2A TH AMPH STX1A NECTIN2 TDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260910%WP2037%HOMO SAPIENS Prolactin signaling JAK2 SOCS2 EIF4EBP1 PTPN1 MAPK9 TEC MAPK3 NFKBIB JAK1 STAT1 MAPK14 STAT3 ELK1 PTPN11 VAV1 GAB2 VAV2 FOS RPS6KB1 CBL RELA GRB2 FLNA SOS1 STAT5A STAT5B NFKBIA SHC1-1 CASP3 PTPN6 SRC PAK1 MYC ERBB2 MAPK8 HRAS RPS6KA2 IRS1 IRS2 JUN RAF1 FYN PIK3CB AKT1 PXN MTOR PIK3CG PRL NEK3 SOCS1 CTSD GSK3B YWHAG PIAS3 CISH RPS6 PIK3R2 PRLR PIK3CA PIK3R1 PTK2 YWHAZ ZAP70 ITGB1 PPIB SOCS3 PPIA MAP2K2;MAP2K1 NFKB1 AGAP2 MAPK1 RAC1 SIRPA;SIRPB1;SIRPG VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260910%WP1533%HOMO SAPIENS Vitamin B12 metabolism SCARB1 SERPINA3 MTRR SERPINE1 PLAT MTR-1 MPO ICAM1 MCEE SAA2;SAA1 CBS;CBSL FGB FGA CUBN SAA2-SAA4;SAA4 MMUT FGG IL6 APOA1 MAT1A F2 RELA F7 SHMT2 PLG LRP2 HBD;HBB APOE LDLR ABCA1 CBLIF MMAB INSR MTHFR SOD2 SOD3 SOD1 IFNG HBA2;HBA1 TCN2 TCN1 CTH ALB TNF IL1B INS;INS-IGF2 APOB CCL5 CCL13;CCL2 CRP NFKB1 NFKB2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260910%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis EGR2 CEBPD CEBPG GATA3 GATA2 KLF15 SREBF1 KLF2 KLF5 CEBPA PPARG DDIT3 CEBPB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260910%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence IDO1 NOS1 IFNG TLR4 TNF IFNB1-4 TP53 CDKN1A KLF5 IL1R2 AHR EIF2AK1 QPRT AADAT EIF2AK4 HAAO FOXO1-1 ACMSD KMO CAT TDO2 KYNU AFMID IDO2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260910%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP2A13;CYP2A6;CYP2A7-1 XDH CYP1A2 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA MECR OXSM HSD17B12 MCAT METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260910%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts SLC2A1 LPAR1 PLOD1 SLC1A5 LOXL2 LDHA GLS ADAMTS2 UGP2 PHGDH PLCG1 CD36 PGM1 PSPH SLC16A1 PYCR1 P3H4 P3H3 RHOA GCK GLUD1;GLUD2 UGDH BMP1 P4HA1 P4HA2 PSAT1 P4HA3 ALDH18A1 FGFR4 SERPINH1 FGFR1 GPI THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260910%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ITGB3 PFKFB2 KDM3B NPR1 UCP1 ITPR2 ADCY8 SLC5A5 TPO RXRA ITGAV NPY PRDM16 BAD MAP4K5 MAPK14 ATF2 PPARGC1A DUOX2 FGF21 SLC16A10 MAFA CTNNB1 TSHR POMC TG RHEB RPS6KB1 AGRP SLC26A4 GRB2 PNPLA2 CASP9 SOS1 SRC SHH TP53 MDM2-2 ADCY3 NOTCH1 HRAS WNT4 FOXO1-1 KLB THRB THRA KDM1A TRH TTF2 RAF1 TTF1 MC4R RPTOR NPPB PRKACA-1 RPS6KA6 NHSL1 IYD TSC2 DUOXA2 MLST8 FGFR1 PRKG2 SLC16A2 TSHB AKT3 ACTL6B SECISBP2L DIO1 MTOR DIO3 TSC1 FRS2 SIRT6 LOC100509620;LOC112267859;AQP7 GSK3B SLCO1C1 CREB3 RPS6 TBC1D4 MAPKAPK3 PIK3CA ADRB3 PAX8 PPARG AKT1S1 ZNF516 MAP2K2;MAP2K1 PLIN1 MAPK1 MGLL LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260910%WP3965%HOMO SAPIENS Lipid metabolism pathway BCKDHA PRKAA1 PNPLA2 PRKAA2 ACSS2 ACACA PRKAG1 PRKAG2 ABHD5 FASN PRKAG3 PRKACB-1 LIPE PRKAR2B PRKAR2A PRKAB2 PDHA1 PRKAB1 PRKACA-1 ACLY PRKAR1B PRKAR1A ACSBG1 AKT2 AKT3 AKT1 PLIN1 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260910%WP2267%HOMO SAPIENS Synaptic vesicle pathway SNAP25 RAB3A CLTC CLTA AP2A1 PARK7 AP2A2 RIMS1 DNM1L SLC18A1 SLC18A2 AP2M1 SLC18A3 NSF UNC13C SLC38A1 UNC13A SLC32A1 SYP SYN3 SYN2 DNM1 DNM2 DNM3 SLC25A4 AP2B1 VAMP2 NAPA SLC22A3 STXBP1 CACNA1B SLC1A3 CACNA1A ATP1A2 CLN8 CPLX2 CPLX1 CPLX3 CLTCL1 AP2S1 SLC17A6 SLC17A7 SLC17A8 STX3 STX2 SYT1 SLC6A4 UNC13B SYN1 STX1A TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260910%WP3945%HOMO SAPIENS TYROBP causal network in microglia C3-1 ITGB2 GAPT C1QC ITGAX STAT5A IL18 GAL3ST4 SPP1 CD4 PYCARD SLC1A5 RPS6KA1 ABCC4 GPX1 CD84 NRROS FKBP15 NCF2 PLEK LOXL3 TGFBR1-1 TCIRG1 LYL1 RGS1 CREB3L2 CD37 IL13RA1 RNASE6 LGALS9C;LGALS9;LGALS9B TNFRSF1B RUNX3 APBB1IP SLC7A7 MAF TYROBP BIN2 ELF4 NPC2 DPYD HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 CAPG SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 ITGAM IL10RA PPP1R18;LOC107987457 LHFPL2 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260910%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development RUNX2 DMP1 KLF4 NOTCH2 DKK1 NOTCH3 DSPP NOTCH1 ALPL SP7 NOTCH4 SOST BMP7 CTNNB1 HNF1A CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 NSDHL SC5D DHCR24 DHCR7 LBR QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260910%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis NOS1 CYP2A13;CYP2A6;CYP2A7-1 IKBKB NFE2L2 MMP1 KEAP1 ACOX2 FOS MAFG MAFK PTGS2-2 VEGFA JUN NFKBIA NFKB1 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260910%WP4262%HOMO SAPIENS Breast cancer pathway DLL1 DLL3 DLL4 WNT11 WNT7B FGF21 CTNNB1 RB1 CDKN1A FOS MRE11 BRCA1 EGF ESR1 CCND1 MYC NBN ERBB2 PGR DDB2 FGF2 TP53 AXIN2 E2F1 KIT GADD45B GADD45A IGF1 GADD45G RAD50 CDK6 RAD51 CDK4 BAX PARP1 ATM ATR JUN RAF1 FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 AKT2 AKT3 AKT1 MTOR GSK3B PIK3R2 PIK3R1 MAP2K2;MAP2K1 NFKB2 MAPK1 MAPK3 NCOA1 IGF1R RPS6KB1 FRAT2 TNFSF11 GRB2 SKP1 CSNK2A2 SFRP4 SOS1 CSNK2B SHC4 SHC1-1 SHC2 TCF7 DVL1 DVL2 FGF20 DVL3 FGF23 FGF22 ESR2 FGF17 FGF16 SP1 FGF19 FLT4 CETN3 PTEN BRCA2 POLK FZD10 APC2 NCOA3 FGF1 AXIN1 FGF3 CSNK2A1;CSNK2A3 FGF4 SOS2 FGF5 LEF1 FGF6 EGFR FGF7 E2F2 FGF8 HES1 FGF9 E2F3 BAK1 HES5 TCF7L2 TCF7L1 WNT5B CSNK1A1 HEYL APC RPS6KB2 NOTCH2 NOTCH3 NOTCH1 NRAS NOTCH4 PIK3R3 HRAS WNT6 WNT1 WNT2 WNT4 JAG2 WNT10B WNT10A KRAS FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 ARAF FGF18 FGF10 FGFR1 WNT2B PIK3CD SHC3 HEY1 HEY2 BRAF WNT16 PIK3CA LRP5 ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP241%HOMO SAPIENS One carbon metabolism ST20-MTHFS;MTHFS ALDH1L1 DNMT1 MTFMT AHCYL2 AHCY SHMT1 MTRR GLRX MAT2B DNMT3A TYMS MTR-1 FTCD ATIC MTHFD1L DNMT3B AMT DHFR2;DHFR BHMT FOLH1B;FOLH1 MTHFD1 MTHFD2 CHDH GART MAT1A SHMT2 MTHFR TCN2 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260910%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling STAT1 STAT3 IL6 IL21 IL22 IL13 IL23R RORC JUN RORA NOD2 HLA-DMA IL18RAP IL10 TBX21 STAT4 SMAD2;SMAD3 IL18 IL21R IL12RB1 IL12RB2 IL2 IFNGR1 NFATC1 IL4 FOXP3 IL1A IFNG IL23A TLR5 MAF TLR2 IL12A TLR4 TNF IL5 GATA3 IL2RG STAT6 IL4R TGFB1 IL17F NFKB1 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260910%WP710%HOMO SAPIENS DNA damage response only ATM dependent MAPK9 WNT11 RAC3 WNT7B MAPK10 CTNNB1 CDKN1A CDKN1B BBC3 CCND3 CCND2 FOSL1 CDC42 CCND1 MYC ERBB2 TP53 MDM2-2 ABL1 PMAIP1 MAPK8 BAX ATM IRS1 MAP3K4 JUN MAP3K1 BCL2 WNT3A WNT5A WNT7A WNT3 RBL2 AKT2 AKT3 AKT1 GSK3B PIK3R2 PIK3R1 TGFB1 NFKB1 NFKB2 MAPK1 RAC1 MAP3K7 BAD PLAU GRB2 SOS1 SHC1-1 TCF7 LDLR DVL1 DVL2 DVL3 INSR HMGB1-1 PTEN AXIN1 SOS2 LEF1 CAT BAK1 TCF7L2 TCF7L1 WNT5B APC NRAS PIK3R4 PIK3R3 HRAS PIK3R5 WNT6 WNT1 WNT2 RHOA WNT4 WNT10B WNT10A KRAS SMAD4 SMAD2;SMAD3 SCP2 PDK1 WNT2B FOXO3 BCL2L11 PIK3CD PCK2 PIK3C2G MLKL PIK3CB G6PC1 PIK3C2A BCL6 PIK3CG TP73 FASLG PIK3C2B PPP2R5E PPP2R5C BIK CDKN2A WNT16 CCNG2 PIK3CA PIK3C3 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260910%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation MAPK3 CDK4 CDK2 IGF1R KRAS FOXO1-1 INS;INS-IGF2 TGFBR1-1 PDGFA MYC INSR SMAD7 AKT2 AKT3 AKT1 BRAF CRTC2 FLT1 FOXM1 RASSF1 IGF1 PDX1 MAPK1 PGF DLK1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260910%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGFR HPGD PTGDR2 EHHADH-1 PLA2G5 PLA2G6 PTGS1 TBXA2R JMJD7-PLA2G4B;PLA2G4B PTGR1-1 PTGDR PTGIR PTGDS ACAA1-1 PTGR2 PTGIS ACOX1 PLA2G4A ACOX3 PPARD CYP4F3;CYP4F2;CYP4F12;CYP4F11 ACOX2 PRXL2B TBXAS1 PTGS2-2 AKR1B1 PPARG PTGES MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260910%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCC1 UQCR11 UQCR10 BCS1L TTC19 UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCRC2 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260910%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 MYC E2F3 PIK3R1 TP53 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260910%WP4236%HOMO SAPIENS Krebs cycle disorders DLST GPT DHTKD1 LDHB LDHA;LDHC LDHA SUCLA2 MPC1 SUCLG2 SUCLG1 PCK2 PDHX FH MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260910%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes COMP COL9A1 MATN1 COL9A3 COL9A2 MATN3 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260910%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways MRE11 BRCA1 CHEK1 NBN RFC1 DDB2 FANCD2 DCLRE1C CCNH MPG FAAP100 LIG1 REV1 LIG4 LIG3 RBX1 MSH6 NEIL3 NEIL2 MSH2 MSH3 CENPS-CORT;CORT;CENPS RPA2 XPA XPC BRIP1 RAD52 NTHL1 RAD50 NHEJ1 FANCI RAD51 FANCM XRCC4 FANCL FANCA XRCC1 FANCC FANCE PALB2 FANCG PARP1 FANCF ATM CDK7 ATR MNAT1 FEN1 WDR48 OGG1 CETN2 POLB EXO1 REV3L POLI POLL POLE POLH RFC5 RFC3 RFC4 RFC2 PARP2 RAD23A ERCC5;BIVM-ERCC5 TERF2 RAD23B DDB1 RAD51C GTF2H2C;GTF2H2C_2;GTF2H2 PNKP FAAP24 UNG RAD54B POLD3 FAN1 POLD4 WRN LOC105377022;FANCB TDG POLD1 POLD2 USP1 PMS2 MUTYH MBD4 CENPX MGMT POLM RPA1 APEX2 GTF2H1 GTF2H3 MLH1 GTF2H4 POLE4 SMUG1 CUL4A ERCC3 ERCC4 POLE2 RPA3 APEX1 ERCC1 POLE3 ERCC2 ERCC8 ERCC6 CUL4B HMGB1-1 BRCA2 POLK PRKDC RAP1A XRCC6 PCNA XRCC5 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260910%WP4814%HOMO SAPIENS Somatic sex determination WT1 RSPO1 PTGDS DMRT1 DHH GATA4 FOXL2 CTNNB1 SOX8 NR5A1 SRY SOX9 WNT4 AMH ZFPM2 FGF9 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260910%WP45%HOMO SAPIENS G1 to S cell cycle control MCM2 POLE2 RPA3 RB1 CDKN1A CDKN1B CDKN1C MCM7 CREB3L3 CREB3L4 CREB3L1 CCND3 CCNA1 CCND2 TFDP1 TFDP2 MCM3 MCM4 MCM5 MCM6 CCND1 PRIM2 MYC ATF6B PRIM1 ORC5 ORC4 CDC45 CDC25A ORC6 ORC1 CREB1 ORC3 CCNE2 ORC2 CDKN2D CDKN2B CCNE1 CDKN2C WEE1 TP53 POLA2 CCNH MDM2-2 CCNB1 E2F1 E2F2 E2F3 GADD45A RPA2 MYT1 CDK6 CDK4 CDK2 CDK1 ATM CDK7 MNAT1 POLE PCNA CREB3 CDKN2A CCNG2 RPA1 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260910%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome STAT5A STAT5B MYC PAK2 TFRC CEP19 HFE SLC40A1 PIGZ CASP7 SENP5 H2BC21 UBXN7 MAD2L1BP-1 SMCO1 PCYT1A NCBP1 FBXW7 ADAM10 SLC51A SLC51B FNDC8 PIGM GRIA1 MYCBP2 RNF168-1 RNF8 FBXO45 HIF1A BRINP1 PIK3R3 TM4SF19 CEP350 MCRS1 PIGX-1 WDR53 SIRT1 ZNF76 RABL2A;RABL2B NCBP2-1 TF DLG1 UBE2N MELTF NRROS NF2 DYNC2H1 HAMP DYNC2I2 JUN CEP43 DYNC2I1 DYNLT1 DYNLT2B DYNC2LI1 DYNLRB2 DYNLRB1 PXN TGFB1 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma MAPK3 BAD STAT3 GAB1 PTPN11 JAK3 CDKN1A HGF RAPGEF1 CBL GRB2 SOS1 CRK SRC CDC42 PAK1 PAK3 PAK2 PAK4 KDR SOS2 VEGFA NRAS MAPK8 PLCG1 PIK3R3 HRAS KRAS JUN ALK ETS1 CRKL ELOA INSL3 TFE3 BUB1B-PAK6;PAK6 RAF1 MET PRCC ARAF RPL11 PAK5 C8orf34 STRN PIK3CD AKT2 AKT3 PIK3CB AKT1 RAP1B RAP1A PIK3R2 BRAF PIK3CA PIK3R1 PTK2 MAP2K2;MAP2K1 MAPK1 RAC1 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260910%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism CYP4F3;CYP4F2;CYP4F12;CYP4F11 FADS2 ACSL1 FADS1 ALOX5 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP560%HOMO SAPIENS TGF beta receptor signaling MAPK9 MAPK3 JAK1 SERPINE1 CREBBP STAT1 ITGB6 STAT3 EP300 CTNNB1 FOS EGF SPP1 IFNG SKIL SMAD7 TNF LEF1 LIF BMP4 RUNX2 HRAS WNT1 SMAD1 SMAD4 JUN TGFBR1-1 TFE3 SMAD2;SMAD3 SMAD9 SMAD5 RUNX3 ZFYVE9 TGIF1-1 FST LEFTY2;LEFTY1 NOG FOXH1 TGFBR3 ZEB2 ENG LTBP1 THBS1 ZNF423 INHBA SMAD6 FKBP1A SKI BAMBI TGFB1 NFKB1 TGFBR2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260910%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 APOA5 LMF1 LIPC APOC2 ANGPTL8 ANGPTL3 ANGPTL4 PLTP GPIHBP1 APOA1 CETP LRP1 SEL1L APOA2 LPL LDLR LCAT NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260910%WP404%HOMO SAPIENS Nucleotide metabolism PRPS2 PRPS1 RRM2B RRM1 ADSL NME2 OAZ1 DHFR2;DHFR SAT1 POLD1 SRM POLA1 IMPDH1 MTHFD2 POLB HPRT1 ADSS2 RRM2-1 POLG ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260910%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ITPR2 GAPDH-1 HSD17B10 IKBKB CHUK RELA APP CALML6 CALML3 CALML4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 ATG14 PSMC2-1 ATG13 DKK2 DKK4 VDAC3 ULK2 ULK1 VDAC1 ATF6 TNF ATF4 APH1A NCSTN GRIN2A PPP3R1 AXIN2 APH1B NRBF2 XBP1 EIF2AK3 EIF2AK2 GRIN2C GRIN2B GRIN2D ATG2A NOX4 CALM1 CALM2 NOX1 ATG2B IDE SLC25A4 RYR3 TUBA1C IL1B PPP3CA PPP3CB TUBA1A PPP3CC PSENEN MAPK8 MME BACE1 CASP8 PSMA5 PSMA6 PLCB3 PSMA3 PLCB4 FADD PSMA4 PSMA1 MAPT TNFRSF1A PLCB1 PLCB2 MAP2K7 TUBB3;TUBB6 PSMA7 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 DDIT3 PSMB2 PSMB3 PSMB1 APBB1 TUBB4B RAF1 CALM3;CALM1 GRIN1 FZD1 PSMA2-1 PSMC5 FZD3 PSMC6 PSMC3 WNT3A PSMC4 WNT5A WNT7A PSMC1 CDK5R1 IRS4 VDAC2-1 WNT3 KIF5C LRP6 AKT2 KIF5B AKT3 KIF5A AKT1 TUBB1 MAP3K5 MTOR CYBB TUBA4A ERN1 ADAM17 PPIF PPID GSK3B RTN3 PIK3R2 PSMD12 PIK3R1 PSMD14 PSMD13 PSEN2 ITPR1 MAP2K2;MAP2K1 CACNA1D GPR83 MAPK1 ITPR3 CACNA1C PSEN1 CACNA1F KLC1 AGER MAPK3 DKK1 RTN4 KLC4 KLC3 KLC2 ATG101 NAE1 BAD CACNA1S TUBA3E;TUBA3C-1 EIF2S1 SEM1 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E MCU TUBA8 ATP2A3 IL6 ATP2A2 ATP2A1 FRAT2 RB1CC1 TUBB2B;TUBB2A TRAF2 CSNK2A2 WIPI1 SFRP4 WIPI2 CSNK2B SLC25A5 SLC25A6 BECN1 TUBAL3 DVL1 BECN2 DVL2 AMBRA1 SNCA DVL3 NOS2 ADRM1 SLC25A31 IL1A FZD10 APC2 AXIN1 CSNK2A1;CSNK2A3 CSNK1A1 WNT5B APC PIK3R4 PIK3R3 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 ARAF CAPN2 CAPN1 WNT2B PIK3CD PIK3CB BRAF WNT16 PIK3CA PIK3C3 LRP5 MAPK9 WNT11 WNT7B MAPK10 CTNNB1 CASP9 CASP3 APAF1 CYCS-1 BID CDK5 FAS IRS1 IRS2 INS;INS-IGF2 CHRNA7;CHRFAM7A NOS1 NFKB1 APOE INSR CSF1 CASP7 ADAM10 NRAS HRAS GNAQ KRAS PTGS2-2 LRP1 LPL VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2877%HOMO SAPIENS Vitamin D receptor pathway IL1RL1 CLMN CREG2 HSD17B2 LRRC8A LRRC25 S100G CDX2 RXRA KRT13 G0S2 MYO9B ATP2B1 DEFB132 CASP5;CASP4 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 PPARD CD9 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DEFB4A;DEFB4B CDKN1A CDKN1B CEBPA CCND1 MYC NRIP1 CCNE1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HNF1A SFRP1 GADD45A NOX1 CDK2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 G6PD FOXO1-1 TNFRSF11B LGALS9C;LGALS9;LGALS9B CTLA4 TGFB2 SULT2A1-4 PRDM1 TGFB1 JUNB CYP27B1 KLF4 CYP2B6 CBS;CBSL CYP2S1 CYP1A1 TNFSF11 SULT1C2 FGF23 STEAP4 SPP1 LPGAT1 GXYLT2 CLDN2 SLC8A1 CYP2D6;LOC107987479;LOC107987478-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 IL12A STS CDKN2D SALL4 CDKN2B SPRR1A;SPRR1B CDKN2C KRT16;KRT14 CYP2C9;CYP2C19 EPHB4 KRT71 PTGER4 IGFBP1 SLC34A2 S100A2 IGFBP3 TPM1 MED9 CDKAL1 CDC34 NINJ1 S100A6 S100A4 S100A9 S100A8 ABCB1 COL13A1 CLEC16A ADRB2 EFNA5 PRKCQ RASGRP1 KNG1 KLK6 CYP7A1 CCNC-1 CRACR2A CRACR2B HIF1A DND1 ALOX5 BTLA CD14 KL SLC37A2 IGFBP5 VDR KRTAP8-1 NFATC2 STAM BMP6 TRPV6 TNFSF4 TRPV5 ID1 PNOC ID4 IGSF9B CLPTM1L MXD1 CYP24A1 CD200 CD40 IL25 TNFAIP3 SLC2A4 ADRA1B TREM1 ORM2;ORM1 THBD ADAMTS5 CASP14 DUSP10 ADGRE5 DNER DACT2 TIMP2 TIMP3 SOSTDC1 BDKRB1 CA9 ABCD1 BCL6 CAMP SERPINB1 IRF4 IRF8 IRF5 COLEC11 SATB1 CDKN2A PTH SEMA3B ASAP2 ATP2C2 TRAK1 ITGAM LRP5 ALPG;ALPP;ALPI-1 CST6 PTHLH CELL CYCLE%WIKIPATHWAYS_20260910%WP179%HOMO SAPIENS Cell cycle MCM2 EP300 RB1 SMC3 CDKN1A CDC14A CDKN1B CDC14B CDC20 CDC23 CDC27 SKP2 ANAPC7 CCND3 CDC25B CCND2 ANAPC4 CHEK2 ANAPC5 MAD1L1 ANAPC1 CHEK1 ANAPC2 E2F4-1 CCND1 ANAPC13 MYC CUL1 PKMYT1 ANAPC10 ANAPC11 SMC1A CDC25C RAD21 CDC25A ZBTB17 PLK1 CDC7 CCNE2 CDC6 STAG1 STAG2 CCNE1 CDC16 YWHAE TP53 YWHAB CCNH MDM2-2 YWHAQ PTTG1;PTTG2 CCNB3 CCNA2-1 CCNB2 YWHAH CCNB1 SMC1B ABL1 RBL1 DBF4 E2F1 RBX1 ESPL1 SFN TTK FZR1 BUB3 GADD45B E2F5 GADD45A BUB1 MAD2L2 WEE2 GADD45G CDK6 HDAC2 CDK4 CDK2 CDK1 ATM CDK7 ATR RBL2 GSK3B YWHAG HDAC1 TGFB2 TGFB1 YWHAZ TGFB3 CDKN1C MCM7 SKP1 CCNA1 TFDP1 TFDP2 MCM3 MCM4 MCM5 MCM6 ORC5 ORC4 CDC45 ORC6 ORC1 ORC3 ORC2 CDKN2D CDKN2B CDKN2C WEE1 E2F2 E2F3 PRKDC SMAD4 SMAD2;SMAD3 PCNA CDKN2A SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260910%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RASGRF1 RAF1 HTR2B HTR2A RASGRP1 ELK4 MAPKAPK2 MAPK3 NRAS HRAS ELK1 GATA4 GNAQ KRAS ITPR1 MAP2K2;MAP2K1 MAPK1 SRF VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260910%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression CACNA1C CYP27B1 ITPR2 TPH1 KDM3A CHRM1 KDM1B RXRA GRM5 CALB1 KDM6B ATP2B1 ATP2B4 ATP2B3 VDR ATP2B2 KCNQ2 KCNQ3 PVALB G6PD GSR TPH2 BCL2 KDM1A GCLC GGT1 GRIN1 SLC8A1 NFE2L2 GRIN2A CYP27A1 GRIN2C GRIN2B GRIN2D ITPR1 ITPR3 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260910%WP206%HOMO SAPIENS Fatty acid omega oxidation ADH4 ADH1C;ADH1B;ADH1A ALDH2 CYP1A1 ALDH1A1 CYP2E1 CYP2A13;CYP2A6;CYP2A7-1 CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260910%WP5548%HOMO SAPIENS Blood based neuroinflammation markers TAC1 TREM1 IL1B GFAP CCL5 TNF CCL13;CCL2 IL6 CRP GRN BDNF ADM TREM2 CX3CL1 CCL23;CCL15 TSPO NEFL CCL11 OLR1 CHI3L1 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260910%WP4155%HOMO SAPIENS Endometrial cancer ILK MAPK3 BAD ELK1 PDPK1 CTNNB1 CDKN1A FOS GRB2 CASP9 SOS1 EGF TCF7 CCND1 MYC ERBB2 DDB2 PTEN FGF2 POLK APC2 TP53 FGF1 AXIN1 AXIN2 SOS2 LEF1 EGFR BAK1 TCF7L2 GADD45B TCF7L1 GADD45A GADD45G APC NRAS PIK3R3 BAX HRAS KRAS RAF1 CDH1 ARAF CTNNA1 CTNNA3 CTNNA2 FGFR3 FGFR2 FGFR1 FOXO3 PIK3CD AKT2 AKT3 PIK3CB AKT1 GSK3B PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260910%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis JAK2 IFNGR1 IFNAR2 JAK1 STAT2 IFNGR2 IFNG TAP1 STAT1 IFI35 IFIT1 PSMB8 IFIT3 PIAS1 MX1-1 TYK2 OAS1 IRF9 PTPN2 IFNAR1 SOCS1 IRF1 IFITM3;IFITM2;IFITM1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260910%WP4971%HOMO SAPIENS Phosphoinositides metabolism MTMR2 MTMR3 MTMR8 MTMR9 MTMR4 MTMR6 MTMR7 MTM1 PLCG2 PIP5K1A PIP5K1B PIP5K1C PIKFYVE PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 INPP5D PTEN PLCG1 PIK3R4 PIP4K2A PLCB3 PLCB4 PLCB1 PLCB2 MTMR10 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG MTMR12 PIK3C2B MTMR11 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2B PIK3CA PIP4K2C SBF1 SBF2 PIK3C3 SACM1L OCRL MTMR1 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260910%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2;SMAD3 TNC RUNX2 CDH1 MAPK3 VIM AKT2 AKT3 AKT1 CDH6 CDH2 SNAI1 SNAI2 ID1 CDH16 SMAD4 FN1 MAPK1 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260910%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MIPEP UBXN1 CLPB MICOS13 TXN2 AIFM1 OPA1 OPA3 C1QBP GDAP1L1 SACS LONP1 UFD1 PMPCB PMPCA UBXN6 SLC25A46 OXA1L AFG3L2 PPA2 CLPP YME1L1 MICU1 PRKN HTRA2 SPG7 DNM1L MFF HSPD1 TIMM50 MSTO1 PITRM1 ATAD3A;ATAD3B MFN1 MFN2 MARCHF5-1 MCL1 HSPA9 DNAJC19 TIMM8A TIMMDC1 USP9X TXNRD2 AGK TMEM126A-1 PYCR2 PYCR3 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 VCP-1 PYCR1 PLEK STAT2 TRAK1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260910%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGM PIGS PIGX-1 PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGQ PIGP PIGW PIGV PIGC DPM2 PIGB PIGA PIGK MPPE1 PIGL PIGG PIGF PIGH INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260910%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway BMP2 DDR1 NQO1 SUV39H1 ANXA5 LOXL4 NRF1 ECSIT PKD1 COL2A1 CDC37 EXOC6 NFE2L2 SIRT1 IGFBP7 FGF7 TGFB1 FN1 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260910%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface CXCL10 SMAD2;SMAD3 IL2RA ITGAE FOXP3 IFNG CD14 SMAD7 CD9 ANGPT2 ITGA1 ANGPT1 CD4 SMURF2 VEGFC FCGR3A;FCGR3B KLRC4-KLRK1;KLRK1 SMAD4 NCAM1 TGFB1 TGFBR1-1 PGF CXCL8 TGFBR2 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260910%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups GATM CPS1 SMS SARDH PYCR3 ASL NAGS CKB OTC PYCR1 SRM GLUD1;GLUD2 GAMT ARG2 ACY1;ABHD14A-ACY1 ALDH18A1 OAT CKM ARG1 ODC1 ASS1 FOLATE METABOLISM%WIKIPATHWAYS_20260910%WP176%HOMO SAPIENS Folate metabolism SCARB1 SERPINA3 MTRR SLC46A1 SERPINE1 PLAT FLAD1 MTR-1 RFK MPO GPX6 ICAM1 IZUMO1R SLC19A1 SAA2;SAA1 FOLR2 CBS;CBSL FOLR1 FGB FGA SAA2-SAA4;SAA4 FGG IL6 APOA1 MAT1A F2 RELA F7 SHMT2 PLG HBD;HBB LDLR ABCA1 INSR MTHFR IL2 SOD2 SOD3 IL4 SOD1 IFNG HBA2;HBA1 CTH ALB TNF TP53 CSF1 CAT ST20-MTHFS;MTHFS IL1B AHCY SHMT1 DHFR2;DHFR MTHFD1 MTHFD2 GPX1 GART GPX4 INS;INS-IGF2 APOB CCL13;CCL2 CRP NFKB1 NFKB2 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260910%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S1 EIF2S2 EIF2S3;EIF2S3B EIF1 EIF3C;EIF3CL EIF5 EIF3I EIF1AY;EIF1AX EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders TAT FAH HPD GSTZ1 HGD PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260910%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELPLG IL1B VCAM1 PF4;PF4V1-1 SELE SELP CD40LG CCL5 TLR2 TLR7 ICAM1 TLR4 CCL13;CCL2 TGFB2 TGFB1 TGFB3 CD40 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260910%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway RASGRF1 JAK2 HTR2A RASGRP1 ELK4 MAPK3 MAPKAPK2 GNAI1 MAPK14 STAT3 ELK1 PDPK1 RHOA GNAQ FOS MAP2K6 MAP2K3 MAP3K1 GNAI3 CREB1 GNAI2 RPS6KA5 HTR1E HTR1F HTR1D HTR1A HTR1B GNAO1 RAP1A BRAF MAPKAPK3 PIK3CA ITPR1 MAP2K2;MAP2K1 MAPK1 SRF INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260910%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MYD88 TRAF6 MAP3K7 MAPK9 MAPK3 MAPKAPK2 NFKBIB MAP2K4 MAPK8 MAPK14 ATF2 ELK1 IKBKB MAPK10 MAPK11 CHUK FOS MAP2K7 EIF4E RELA MAP2K6 MAP2K3 MAP3K1 NFKBIA MYC IL1A IL1R1 RPS6KA5 MBP IL1RAP TANK IRAK1 IRAK2 MKNK1 MKNK2 MAP3K8 MAP3K3 IRF7 SAFB TOLLIP IRAK4 TAB3 MAP2K2;MAP2K1 NFKB1 TAB2 MAPK1 TAB1 MAP3K14 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260910%WP4157%HOMO SAPIENS GABA metabolism aka GHB PON3 ALDH5A1 MAOB GLS2 GAD1 GLS ADHFE1 DPEP1 GAD2 ABAT AKR7A2 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma JAK2 IL6R JAK1 IL11RA ZEB1 STAT3 IL11 JAK3 IL6 RELA IL6ST SOX4 NFKB1 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260910%WP4918%HOMO SAPIENS Cellular proteostasis PFDN5 PFDN6 PFDN4-1 VBP1 PFDN1 PFDN2 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260910%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function SLC2A1 PRKCA C3-1 PRKCQ AGER PRKCD PRKCZ MMP1 MMP21 MMP20 MMP25 MMP24 MMP27 MMP2 MMP28 BDNF SCN9A TKTL1 MMP9 MMP7 TRPA1 MMP3 SORD TRPV1 MMP8 MMP10 MMP12 NOS2 MMP11 SCN10A MMP14 MMP13 MMP16 PRKD3 MMP15 SNAP25 MMP23B SCN8A MMP17 MMP19 PRKCG PRKCI PRKCH PRKCB PRKCE AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260910%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GLYAT ACSS2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260910%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A NAD METABOLISM%WIKIPATHWAYS_20260910%WP3644%HOMO SAPIENS NAD metabolism PARP1 NRK SIRT4 SIRT5 NMNAT3 SIRT1 NMNAT2 SIRT2 SIRT3 SIRT6 NMNAT1 NAMPT CD38 NADK NT5E FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260910%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling PFKFB2 PRKAA1 ATF2 PPARGC1A IKBKB FGF21 JAK3 RHEB PRKAA2 EGF FN1 LIPE EPO TNC KDR PDGFB ULK1 PDGFRB FGF2 ATF4 KIT IGF1 EIF4E CREB3L2 RAF1 IRS4 AKT2 AKT3 AKT1 MTOR GSK3B TCL1B PIK3R2 TCL1A PIK3R1 PPP2R1B PPP2R1A DDIT4 PPP2R2A;PPP2R2D MAP2K2;MAP2K1 EPHA2 MAPK1 EPAS1 LPAR2 JAK2 LPAR3 IL6R LPAR4 GNG10 PDGFD MAPK3 PDGFC JAK1 NGFR GNG13 COL1A1 COL1A2 LPAR5 BAD LPAR6 CAB39L HIF3A GYS2 GNGT1 GYS1 IKBKG RAB8A STRADA OSMR PHLPP2 IGF1R RPS6KB1 TNXB GRB2 PHLPP1 CAB39 COL11A1 COL11A2 SOS1 RELN VEGFB OSM VEGFD RAB11B KITLG COL3A1 FGF20 CHRM2 NOS2 CSF3R IL2 STK11 FGF22 IBSP TNN FGF17 TNR FGF16 RAB2A PDGFRA FGF19 F2R FLT4 COL4A2 COL4A1 PTEN EIF4E1B COL4A4 COL4A6 PFKFB1 FGF1 CSF1R FGF3 PFKFB4 FGF4 PFKFB3 EFNA4 EGFR FGF6 HSP90B1 FGF7 VTN FGF8 CHAD FGF9 EFNA1 EFNA3 EFNA2 FGF14 COL5A1 COL5A3 GNB2 COL5A2 GNB1 RPS6KB2 GNB4 EFNA5 GNB3 IL7R FGF13 FGF12 FGF11 HSP90AB1 LAMC3 SLC2A2 PIK3R4 LAMC2 LAMC1 ELAVL1 GHR PIK3R5 HSP90AA1 VWF PPP2R5B PPP2R5A PPP2R5D NGF TBC1D1 COL6A2 IL3RA EIF4E2 CREB5 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 THBS4 SLC2A4 THBS3 ITGA2B GNG2 GNG5 FGF18 PPP2R3C FGFR4 GNG4 GNG8 FGFR3 EIF4B FGFR2 ANGPT4 LAMB3 FGF10 NOS3 FGFR1 LAMB2 LAMB1 FOXO3 PPP2R3A PIK3CD EPOR RAB10 PIK3CB PPP2R2C PIK3C2A RAB14 PIK3CG PIK3IP1 PPP2R2B PIK3C2B TEK PPP2R5E PPP2R5C PTK2 CRTC2 PIK3CA ITGA10 FLT1 ITGA11 ITGB1 ITGAM PGF ITGB5 ITGB4 ITGB3 ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGAV ITGB7 ITGB6 ITGA4 PDPK1 ITGA3 ITGA2 CDKN1A CDKN1B ITGAD ITGA8 ITGA7 ITGA6 CASP9 ITGA5 ITGA9 COMP CREB1 IFNB1-4 MDM2-2 CHRM1 FOXA1 SREBF1 IRS1 IRS2 FOXO1-1 ACACA INS;INS-IGF2 PPP2CB;PPP2CA IFNAR2 NOS1 TSC2 IFNAR1 PRL IL2RG RPS6 IL4R PRLR EIF4EBP1 IL2RA IL2RB CSF3 HGF CREB3L3 CREB3L4 CREB3L1 PDGFA INSR ATF6B SPP1 CSF1 VEGFA SLC2A1 LPAR1 NRAS HIF1A HRAS KRAS MET RPTOR MLST8 COL2A1 CDC37 ANGPT2 TSC1 ANGPT1 THBS1 VEGFC CREB3 AKT1S1 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260910%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 MYC MAPK3 ELK1 FOS SOS2 KSR1 GAREM2 KRAS BRAF JUN ALK SOS1 SHC1-1 MAP2K2;MAP2K1 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260910%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases SNCA MAOB STAT1 BACE1 AKT2 AKT3 AKT1 MAPT SRPK2 NTRK2 BDNF APP SET-1 TARDBP LGMN CEBPB PPP2CB;PPP2CA METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260910%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway TAT IL4I1 MTAP MAT2A SMS ADI1 MSRB2 AHCY MSRB3 ENOPH1 MAT2B MTR-1 BHMT SRM CHDH MAT1A AMD1 APIP MRI1 ODC1 TXN MSRA CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260910%WP3594%HOMO SAPIENS Circadian rhythm genes PRKAA1 PPARGC1A EP300 AGRP PRKAA2 NRIP1 ATF4 HNF1B MAPK8 JUN PROX1 NAMPT GSK3B HDAC1 NGFR TPTEP2-CSNK1E;CSNK1E NR2F6 IL6 PHLPP1 SKP1 NOS2 PTEN PRKCG AHCY PRKDC TYMS ID4 HS3ST2 RORC RORA PPARG MAPK9 PRF1 HNRNPU CCAR2 HTR7 PROK2 BTRC PROK1 UTS2R MAPK10 CPT1A METTL3 SOX14 CSNK1D CLDN4 ATF5 UBA52 CLOCK DHX9 MAGED1 NKX2-1 OGT-1 EGR1 JUND EGR3 HOMER1 ROCK2 NR1D2 NR1D1 SETX STAR CUL1 NMS HNRNPD ID3 FBXL3 ADA ID2-1 TOP2A CREB1 SUV39H2 BHLHE41 PRMT5 NCOA2 KCND2 TP53 PAX4 MC3R NCOR1 KCNMA1 AVP PPARA CIPC DDC ADCY1 ARNTL2 RELB ARNTL CST3 NPS PROKR1 PROKR2 NFIL3 PML SIK1;SIK1B RPS27A UBB;UBC ARNT2 CAVIN3 NR1H3 HDAC2 TPH1 PPP1CA CDK4 PER2 PER1 CHRM1 MYBBP1A GHRH FAS GHRL LGR4 EZH2 CRTC1 NPY2R UBE3A RORB PPP1CB PPP1CC SREBF1 NAGLU ADORA1 CHRNB2 FBXW11 MTTP KCNH7 ADIPOQ USP2 DYRK1A CARTPT TPH2 SLC9A3 MTNR1A MTNR1B PSPC1 TIMELESS DDX5 MAGEL2 KMT2A SLC6A4 CREM TNFRSF11A NPAS2 RAI1 AANAT DRD1 DRD2 DRD3 DRD4 ZFHX3 OPN4 OPN3 ADORA2A TH NONO GFPT1 BTBD9 BHLHE40 RBM4;RBM4B KDM5A HEBP1 DBP SIN3A SIX3 SFPQ-1 KLF10 ARNT THRAP3 CRY2 CRY1 CRH TOP1 NLGN1 HDAC3 CRX OPRL1 CIART ATOH7 MTA1 SERPINE1 GNA11 NOCT NTRK1 NTRK3 HCRTR2 HCRTR1 LEP KLF9 SFTPC F7 AHR PTGDS SIRT1 GNAQ SUV39H1 PRKG2 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP5094%HOMO SAPIENS Orexin receptor pathway EIF4EBP1 MAPK9 MAPK3 MAPK7 PRKAA1 GNA11 NPY PRKCD MAPK14 STAT3 HCRTR2 HCRTR1 PDPK1 PTPN11 LEP NPFFR1 DAGLA PLCD1 ARRB1 POMC ARRB2 SGK1-1 IL6 FSHB RPS6KB1 RRAGC LHB CASP9 SLC1A2 PDHB PLD1 CAMKK2 NPVF CASP3 IL10 VHL CGA CXCL8 HCRT OPRK1 GCG CCK STAR IL9 GNRH1 IL4 CREB1 BMP7 TNF NFE2L2 CXCL2;CXCL3;CXCL1-1 NOX4 PRKCB PRKCE SLC2A1 PRKCA RUNX2 IL1B PRKD1 GRIA1 GNAI1 MAPK8 HIF1A GHRL PRKCZ GNAS-1 RPS6KA1 GNAQ SMAD1 ADIPOQ FOXO1-1 DYNLT1 SLC2A4 SMAD5 EIF4B BMPR1A PDK1 TH MTOR RPS6 PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260910%WP5443%HOMO SAPIENS Effects of MFN2 mutation SNCA RAB3B DCTN1 ATAT1 DYNC1LI2 RHOT1 SYPL1 RAB3A CASP8 MAP2 BAX KIF1B RABAC1 RAB7A TP53 DYNC1I1 TUBB3;TUBB6 DYNC2H1 MFN2 DYNC2I2 DYNC1H1 DYNC2I1 TRAK1 CASP3 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260910%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC3 HDAC2 PPP3CA PPP3CB PPP3CC CREBBP EP300 NFATC2 RELA NFKBIA NFATC1 SP1 HDAC4 HDAC5 CCNT1 HDAC8 HDAC9 PPP3R1 HDAC7 NELFB NELFA NELFCD HDAC1 NELFE SUPT4H1-1 HEXIM1 NFATC3 SUPT5H NFATC4 NFKB1 CDK9 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260910%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production PRKCA CLCN5 SLC26A6 MAPK3 PRKAA1 SLC5A5 TPO ELK1 DUOX2 TSHR PLCD1 TG PRKAA2 CGA TRH RAF1 CREB1 RAP1B RAP1A ACY1;ABHD14A-ACY1 MAP2K2;MAP2K1 NFKB1 DUOX1 MAPK1 ANO1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260910%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV NLGN1 NLGN3 CAMK2B CYFIP1 MAPK3 RYR2 CAMK2D NLGN2 FMR1 CAMK2A NRXN3 NRXN2 GRM1 RPH3A SYNGAP1 DLGAP1 CAMK2G NLGN4X;NLGN4Y NRXN1;NRXN3;NRXN2 TJP1 ARC DLG1 DLG2 SHANK1 HOMER1 GRIN1 GRIN2A STX1A YWHAG GRIN2C GRIN2B GRIN2D MAPK1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260910%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 F12 BDKRB2 SERPING1 KLKB1 CPN1 BDKRB1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2881%HOMO SAPIENS Estrogen receptor pathway SP1 STAT3 ACOX1 CYP1A2 CYP1B1 CYP1A1 PPARA JUN NR0B2 GPAM ESR1 PDK4 PCK1 SARS COV 2 ENVELOPE LIPID COMPOSITION AND HUMAN CELL BINDING%WIKIPATHWAYS_20260910%WP5255%HOMO SAPIENS SARS CoV 2 envelope lipid composition and human cell binding AXL CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260910%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism CYB5A H6PD CYP19A1 STAR SRD5A2 HSD17B3 HSD11B1 CYP17A1 HSD11B2 POR HSD3B1;HSD3B2 CYP11A1 CYP21A2 CYP11B1;CYP11B2 OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260910%WP5574%HOMO SAPIENS Oligodendrocyte development PRKCA BMP4 MAG NFATC2 SOX11 SOX2 SMAD1 BMP1 WNT10A ID4 RELN ID2-1 MYRF PDGFRA CHD8 CHD7 ASCL1 PTN FGF2 EGR2 ZNF24 DUSP15 GLI2 SHH PTPRZ1 SOX8 NKX6-1 ZEB2 MBP ZNF488 SOX9 LGI1 SOX6 OPALIN SOX5 ZBTB33 NKX2-2 TMEM98 NKX2-6 NFIA CNTN1 CSPG4 HES5 TCF7L2 OLIG1 OLIG2 MYT1 SOX10 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260910%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260910%WP2363%HOMO SAPIENS Gastric cancer network 2 BRIX1 UBE2C ATAD2 FANCI CACYBP FAM91A1 RNF144B UBE2T SNURF CEBPZ RAD17 CD48 LBR CTNNB1 RFC3 RFC4 MYC TOP2A COL9A1 COL9A3 TP53 EGFR OTUD5 AHCTF1 S100A6 DSCC1 CHTF18 LMNB2 MTDH PLAC8 ESTROGEN SIGNALING%WIKIPATHWAYS_20260910%WP712%HOMO SAPIENS Estrogen signaling GNB1 MAPK9 PRKACA-1 SP1 CREB1 GPER1 MAPK14 ELK1 IKBKB GNGT1 AKT1 CHUK GNAS-1 IKBKG FOS BRAF JUN PIK3CA NFKB1 MAP2K2;MAP2K1 BCL2 ESR1 MAPK1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260910%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance CDKN1A HIF1A BCL2L1 ABCB1 WNT6 TP53 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260910%WP3927%HOMO SAPIENS BMP signaling in eyelid development BMP4 TGFA SMAD5 MAPK9 MAPK3 NOTCH1 DKK2 FGFR2 FGF10 FOXC2 FOXC1 INHBB PITX2 SHH SMAD1 EGFR SFRP1 SMAD4 JUN MAP3K1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades C3-1 C1QC SERPINA1 SERPINE1 PLAT PLAU PROS1 CLU FGB SERPINA5 C8G C3AR1 LOC110384692;C4A;C4B_2;C4B CR2 SERPINF2 PLAUR F2 F3 F7 F5 F8 PLG F9 MASP2 MASP1 CFB CFD C1QB CPB2 C1S C1R SERPINC1 CFI C5AR1 TFPI C2 LMAN1 F2R C6 CLTC C7 C9 CD55 F10 SERPIND1 CR1L;CR1 PROC F13B CFH-3 KNG1 VWF F12 SERPING1 KLKB1 THBD BDKRB1 APOA2 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260910%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC6A3 SLC18A2 PNMT COMT DDC TPH1 MAOA TPH2 TH DBH CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260910%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC3 ABCC2 CYP2D6;LOC107987479;LOC107987478-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260910%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders PDXK PNPO ALPL PLPBP ALDH7A1 PIGV ALPG;ALPP;ALPI-1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260910%WP363%HOMO SAPIENS Wnt signaling NetPath PRKCA TCF4 ROR1 MAP3K7 CDK6 ROR2 MAPK9 PI4K2A CSNK1G1 MAPK8 PIP5K1B NFATC2 CTNNB1 TPTEP2-CSNK1E;CSNK1E RHOA CSNK1D ARRB2 DVL1 DVL2 CCND1 DVL3 TSC2 LRP6 AKT1 MTOR AXIN1 TSC1 LEF1 GSK3B PRKCG GSK3A CTBP1 NLK TCF7L2 PPARG SOX1 LRP5 GCKR CSNK1A1 MAPK1 PRKCB RYK-1 RAC1 BCL9 APC FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260910%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 STAT3 IL10 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260910%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PI4K2A MOGAT3 PLA2G2A-1 PGS1 PTDSS1 GPAT4 PIP5K1A PTPMT1 GPAT3 GPAT2 CEPT1 CDIPT CHKB PCYT2 GK IPMK CRLS1 GNPAT GPD1 AGPS PEMT CHPT1 LPIN1 LPIN2 CDS2 GPAM PIK3CD PIK3CB PIK3CG PIK3CA PPAR SIGNALING%WIKIPATHWAYS_20260910%WP3942%HOMO SAPIENS PPAR signaling UBB;UBC APOA5 ILK EHHADH-1 UCP1 NR1H3 CYP7A1 ANGPTL4 RXRA PLTP CD36 ACAA1-1 ACOX1 PDPK1 PPARD MMP1 GK CYP8B1 APOA1 ADIPOQ SLC27A1 RXRB CPT2 OLR1 SLC27A5 ME1 PCK1 HMGCS2 RXRG APOC3 CPT1C FABP1 FABP3 FADS2 FABP4 ACSL1 SCD SORBS1 SLC27A4 SCP2 PCK2 PPARA LOC100509620;LOC112267859;AQP7 CYP27A1 PPARG APOA2 LPL PLIN1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260910%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation MTOR PIK3CG GRK1 PIK3CA FPR2 EPHB2 PDK1 LTB4R PIK3CD CMKLR1 AKT1 PIK3CB ID SIGNALING%WIKIPATHWAYS_20260910%WP53%HOMO SAPIENS ID signaling ELK4 ID3 CDK2 ID2-1 RBL2 ELK1 CCNE1 PAX5 ELK3 RB1 SREBF1 PAX2 RBL1 ID1 MYOD1 PAX8 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260910%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia IL6R IL1B JAK1 STAT3 IKBKB EP300 MAPK11 IKBKG CHUK TNFRSF1A IL6 IGF1R RELA SMAD4 NFKBIA CEBPB SMAD2;SMAD3 RPTOR IL1A IL1R1 FBXO32 MLST8 PDK1 FOXO3 TNF AKT1 MSTN MTOR MAP1LC3A TRIM63 TNFRSF12A ACVR2A REL RELB IGF1 AKT1S1 NFKB1 NFKB2 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260910%WP550%HOMO SAPIENS Biogenic amine synthesis COMT TPH1 GAD1 AANAT GAD2 TH PNMT DDC MAOA HDC CHAT ASMT PAH ACHE DBH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP138%HOMO SAPIENS Androgen receptor signaling ZMIZ1 RACK1 PIAS4 NCOA4 ETV5 PIAS2 NCOA1 TLE5 RHOB NCOR2 CREBBP AR ZNF318 FKBP4 RNF6 STAT3 RNF4 NR2C2 EP300 PSMC3IP PRDX1 CTNNB1 RB1 BAG1 RLN2;RLN1 PATZ1 SMARCE1 UBE2I BRCA1 LIMK2 RELA DSTN CARM1 FLNA STUB1 RAN ROCK1 ROCK2 SRC CDC42 CCND1 SP1 CREB1 PTEN NCOA2 CCNE1 PARK7 NCOA3 MDM2-2 NCOR1 EGFR RUNX2 UBE3A RAD9A SIRT1 RHOA SMAD4 FOXO1-1 JUN TGFB1I1 NR0B2 KDM1A BUB1B-PAK6;PAK6 SMAD2;SMAD3 KAT2B TGIF1-1 PIAS1 AKT1 DAXX GSK3B SIN3A PIAS3 HDAC1 CAV1 PIK3R2 PIK3R1 PTK2 CALR-1 RNF14 FHL2 EFCAB6 KAT5 SMIM40 SUMO1 RAC1 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260910%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY3 MAPK3 ADCY8 NRAS HRAS WWTR1 CCN2 LBR RHOA MAP3K9 KRAS SMAD4 GRB2 SOS1 ADCY4 ADCY2 SYNE4 SYNE3 ADCY7 ADCY6 SMAD2;SMAD3 SYNE2 SYNE1 ADCY5 TMEM43 CFL1 BANF1 EMD TMPO SUN1 LEMD3 ADCY10 ADCY9 KIF5B PLEC SOS2 ADCY1 TGFB2 TGFB1 TGFB3 MAP2K2;MAP2K1 MAPK1 SRF ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5393%HOMO SAPIENS Androgen biosynthesis SRD5A2 AKR1D1 HSD17B2 HSD17B3 HSD11B1 CYP17A1 HSD11B2 POR HSD3B1;HSD3B2 SRD5A1 HSD17B4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B1 SULT2A1-4 CYP11B1;CYP11B2 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma CS MDH2 NMRK2 HSPE1 SLC19A2 FH NONO TFE3 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP4159%HOMO SAPIENS GABA receptor signaling GABRA1 GABRP AP2B1 GABBR1 GABRA6 GABRA5 GAD1 GABRA4 GABRA3 SLC6A11 GAD2 GABRG1 ABAT ALDH9A1 AP2S1 SLC6A1 AP2A1 AP2A2 AP2M1 GABRB3 GABRB2 GABRB1 GPHN GABRG3;GABRG2 SLC32A1 GABRE GABRD GABRQ GABRA2 GABBR2 SIGNALING LIPIDS%WIKIPATHWAYS_20260910%WP5584%HOMO SAPIENS Signaling lipids HPGD ALOX15 ALOX12 LTC4S CYP7A1 CYP2B6 ALOX5 PLA2G1B LTA4H PTGDS CBR1-1 PLA1A EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PRXL2B PLCB1 CYP8B1 TBXAS1 GPX4 PTGS2-2 FADS2 CYP2C9;CYP2C19 CYP7B1 CYP27A1 PTGES SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1B1 FMO3 MSRB2 MSRB3 CYP1A2 MSRA NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260910%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection NPR1 CAMK2B IL1B CAMK2D CAMK2A BAD GUCY1B1 XIAP AKAP9-1 NPPA CAMK2G CNGA1 CNGA2 CNGA3 CNGA4 GUCY1A2 GUCY1A1 RELA ACTN2 CASP9 PDE2A DLG4 PDE3A CNGB3 TSPO NFKBIA CNGB1 NEFL BCL2 NOS2 GRIN1 NPPB NOS1 IFNG NOS3 CREB1 PRKG2 TNF CYCS-1 GRIN2A PPID GRIN2C GRIN2B GRIN2D NFKB1 CALM1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260910%WP5178%HOMO SAPIENS Disorders of fructose metabolism KHK PFKL ALDOB FBP1 SLC2A2 HK1 PGM1 G6PC1 ALDH1A1 TPI1 SORD GLYCTK GPI SLC5A1-1 IL11 SIGNALING%WIKIPATHWAYS_20260910%WP2332%HOMO SAPIENS IL11 signaling JAK2 RUNX2 MAPK3 JAK1 STAT1 IL11RA ICAM1 HRAS STAT3 IKBKB YES1 PDPK1 PTPN11 TYK2 ITGA2 CHUK RPS6KA1 RPS6KB1 RELA GRB2 IL6ST FES BCL2 SRC RAF1 ATF1 PTPA IBSP BIRC5 CREB1 FYN IL11 PIAS1 AKT1 PIAS3 PIK3R2 RPS6 PIK3R1 TGFB1 SOCS3 MAP2K2;MAP2K1 MAPK1 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260910%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids CDS1 DGAT2 PTDSS1 DGAT1 GPAT4 PLA2G1B DGKZ PISD AGPAT4 PTDSS2 ETNK1 CDIPT CHKB PNPLA3 PCYT2 CRLS1 PEMT PNPLA2 CHPT1 PLD1 PCYT1A GPAM MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260910%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260910%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation MAPK3 PLCG2 PLCG1 MAPK14 IL12B PLCB3 IKBKB PLCB4 PLCD3 PLCD4 IKBKG CHUK PLCD1 PLCB1 IL6 PLCB2 RELA NFKBIA CXCL8 IL12A PIK3CD TNF AKT2 AKT3 PIK3CB AKT1 PIK3CG RETN PLCE1 PIK3CA ITPR1 NFKB1 MAPK1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2858%HOMO SAPIENS Ectoderm differentiation MZF1 ASTN1 LY6E ARX GATA6 STC1 ARHGAP15 ZBTB2 TRPM2 SDCBP PODXL ST8SIA4 HESX1 PLXNA2 ZBTB7B GAS2L1 PPARD TFAP2A CTNNB1 TFAP2C JUP SMURF1 ZBTB16 GREB1 NR2F2 POU2F2 ZFHX4 PAN2 OGT-1 AHI1 PLCXD3 PRKAG2 PTPRB PPFIBP2 MAFB CCDC88C PI4KA MKS1 MYC CCDC130 EDA NUMA1 HMGB2 LDB2 EDA2R WDR44 PHF8 SIX6 BOC UBTF RAB8B BCAS3 SHH ELOVL4 TSC22D1 ELOVL2 PAX3 SORCS1 PAX6 BAZ1A FOXL1 RGMA CLDN11 ARHGAP10 TOX3 CTBP1 KIFC3 STX16 RRBP1 JAKMIP1 HDAC6 BMP4 IQCJ-SCHIP1;SCHIP1 DMD ROR2 SERPINB6-2 CLVS1 CAP2 TTC14 C1GALT1 PTPN13 VAX2 LHX1 RIT1 GLB1 SGSM3 ZNF219 SPRY2 BCOR PDE7A TRIM33 MYORG ABCC4 SOX2 TNFRSF11B FOXA2 CTNNA2 FYN CCL13;CCL2 NLK FHL2 SOCS2 NLGN1 TLE5 MECP2 CDH6 SNCA SKIL TCF7L1 PGM1 WNT1 SMAD4 NF2 FZD5 FZD4 FZD8 NFATC1 FGFR2 BMPR1A GLI3 HDAC10 CTNND2 ARHGDIG CELSR2 TSKU CDH8 NARS2 PIM1 ANKS1B CDON KCNK10 GRAMD1B-1 KRT6B;KRT6C;KRT6A METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases LIPC APOC2 SCARB1 ANXA2 PCSK9 LIPG APOA1 LDLRAP1 MTTP CETP APOA2 APOE APOB LPL LDLR ABCA1 LCAT AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260910%WP1403%HOMO SAPIENS AMP activated protein kinase signaling EIF4EBP1 PRKAA1 GYS2 LEP CPT1A GYS1 CDKN1A STRADA RPS6KB1 PRKAA2 CAB39 PRKAG1 CCNA1 PRKAG2 CAMKK2 PRKAG3 PRKACB-1 LIPE PRKAB2 INSR STK11 PRKAB1 HNF4A TP53 CCNA2-1 PFKFB3 CCNB1 RPS6KB2 PIK3R3 ELAVL1 SREBF1 PLCB1 ADRA1A EEF2K ADIPOQ LEPR STRADB ACACA INS;INS-IGF2 CPT1B ADIPOR1 ACACB FASN ADIPOR2 CAMKK1 PPARGC1B EEF2 SLC2A4 SLC2A4RG ADRA1B RPTOR CPT1C TSC2 PIK3CD AKT2 PIK3CB AKT1 MTOR PIK3CG HMGCR TSC1 PIK3R2 CRTC2 PIK3CA PIK3R1 PIK3C3 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260910%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway IL1B CASP8 DUOX2 CASP5;CASP4 XIAP IKBKB HSP90AA1 IKBKG CHUK RELA CASP9 NOD2 NFKBIA IL18 NDUFA13 NOD1 NLRC4 MEFV NLRP7;NLRP2 NLRP4 NLRP1 AAMP RIPK2 CARD9 ERBIN CARD6 NLRP12 COPS6 ACAP1 AIM2 NLRP10 SUGT1 NAIP PYCARD CASP7 CASP1 NLRP3 PRDM1 RAC1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260910%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response TRIB3 ERP27 ATF3 BBC3 DDIT3 BCL2L11 ATF6 ATF4 NFE2L2 ERN1 PPP1R15A HSP90B1 NARS1 XBP1 DNAJB9 EIF2AK3 EIF2A HSPA5 UBE2E1 CALR-1 ASNS EDEM1-1 PDIA6 WARS1 DNAJC3-1 DNAJB11 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling GCLM GSTP1 NQO2 SRXN1 ABCC6 NQO1 HMOX1 ABCG2 CES1 MAPK8 MAPK14 MAPK12 MAPK13 EPHX1 MAPK11 NFE2L2 ABCC3 KEAP1 ABCC4 FOS ABCC2 JUN GCLC AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260910%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS GRIA1 PPP3CA PPP3CB PPP3CC TOMM40 DERL1 NEFM BAD NEFH MAPK14 BAX PRPH CCS ALS2 RAB5A TNFRSF1A GPX1 MAP2K6 SLC1A2 CASP9 BCL2L1 CASP3 NEFL BCL2 APAF1 NOS1 SOD1 TNF TP53 MAP3K5 DAXX CASP1 BID CAT CST3 MAP2K2;MAP2K1 SMIM40 RAC1 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5103%HOMO SAPIENS Progeria associated lipodystrophy SMAD2;SMAD3 ICMT LMNA BANF1 ZMPSTE24 PARP1 WRN KCNJ6 POLD1 MUCL3 RECQL LMNB1 FNTA FFAR3;GPR42 SPRTN SMAD4 FBN1 TGFB1 INS;INS-IGF2 PPARG LMNB2 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260910%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A2 RETINOL METABOLISM%WIKIPATHWAYS_20260910%WP5188%HOMO SAPIENS Retinol metabolism LRAT RDH13 BCO1 CYP2A13;CYP2A6;CYP2A7-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP1A1 ALDH1A1 RPE65 DHRS4 SDR16C5 CYP2W1 DHRS9 RDH12 AWAT2 PNPLA4 AOX1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260910%WP3407%HOMO SAPIENS FTO obesity variant mechanism FTO TBX1 UCP1 IRX5 IRX3 ARID5B PRDM16 PPARGC1A CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260910%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R3 PIK3CD PTPN11 CD86 PIK3CB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD80 CTLA4 PIK3R2 PIK3R1 PIK3CA CD28 PPP2CB;PPP2CA PTPN6 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GALT2 B3GNT5 B3GALT1 FUT2 FUT1 FUT6;FUT5;FUT3 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260910%WP615%HOMO SAPIENS Senescence and autophagy in cancer MAPK14 RB1 CDKN1A CDKN1B CDC25B FN1 SRC ATG14 ATG13 ULK1 IFNB1-4 TP53 MDM2-2 IL3 E2F1 CXCL2;CXCL3;CXCL1-1 IGF1 BMP2 IL1B MAP2K3 JUN INS;INS-IGF2 BCL2 RAF1 KMT2A MMP14 MTOR MAP1LC3A GSK3B TGFB1 MAP2K2;MAP2K1 MAPK1 IL6R SERPINE1 COL1A1 PLAT PLAU IL6 IGF1R RB1CC1 IRF1 IL6ST CCL3L1;CCL3L3;CCL3;CCL18 BECN1 CEBPB CXCL8 AMBRA1 COL3A1 IL1A IFNG PTEN SPARC CXCL14 LAMP1 LAMP2 SLC39A2 SLC39A1 SLC39A4 SLC39A3 IGFBP3 SH3GLB1 ATG3 VTN MAP1LC3B2;MAP1LC3B-1 GABARAPL2 ATG10 IRF7 ATG12-1 FKBP8 SQSTM1 GABARAP ATG7 ATG5 UVRAG TNFSF15 ATG16L1 IL24 BMI1 ING1 ING2 MAP1LC3C COL10A1 SERPINB2 CD44 RNASEL HRAS IFI16 CREG1 IGFBP5 GSN RSL1D1 SMAD4 SMAD2;SMAD3 MLST8 IGFBP7 THBS1 PCNA INHBA IRF5 CDKN2A BRAF AKT1S1 PIK3C3 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260910%WP26%HOMO SAPIENS S1P receptor signal transduction MAPK3 GNAI1 MAPK7 MAPK6 MAPK4 MAPK12 PLCB3 ASAH1 SMPD2 RACGAP1 S1PR1 PLCB1 S1PR3 PLCB2 S1PR2 S1PR5 SPHK2 SPHK1 GNAI3 GNAI2 AKT2 AKT3 AKT1 PIK3C2B MAPK1 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260910%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PRKCA MAPKAPK2 CDK1 NTRK1 NTRK3 STAT3 GNAQ MAPT TRIO TESK2 AURKB MAPRE1-1 ROCK1 SPRED1 PARD6A SRC DPYSL2 DVL1 CDC42 CFL2 PAK1 STMN1 RHO TPPP MARK2 CLASP1 PRKACA-1 MARK1 WNT3A LIMK1 TIAM1 DIAPH1 CLIP1 PTPRA EPHB2 TAOK1 PTEN CAMK4 MAP1B KIF2C AKT1 PHLDB2 F2RL2 ABL1 GSK3B NTRK2 RAC1 APC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260910%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy MTMR2 NEFL RAB11B RAB3B RAB3A KIF1B RABAC1 EGR2 RAB7A LRSAM1 HSPB8 HSPB1 NDRG1 LITAF FGD4 SH3TC2 RAB25 MFN2 MPZ RAB4A RAB4B SBF2 GDAP1 RAB11A FIG4 DNM2 PMP22 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260910%WP5145%HOMO SAPIENS COVID 19 structural coverage map NRP1 IGHMBP2 UBB;UBC MACROH2A2 MACROH2A1 MRM2 MACROD1 MACROD2 CMTR1 PAIP1 TOMM70 UPF2 UPF1 AQR SLC6A19 ISG15 PARP14 PARP9 MPP5 GDAP2 APOA1 UBA52 NLRP12 ACE2 TAB1 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260910%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB3 CACNA1C CACNA1F ITGB8 ITGAV ITGB7 ITGB6 CACNA1S ITGA4 ITGA3 ITGA2 CTNNB1 DSP ITGA1 JUP ACTG1 CDH2 ATP2A2 GJA1 ITGA8 SGCD SGCA ITGA7 SGCB ITGA6 DAG1 ITGA5 SGCG ACTN3 ACTN1 CACNA2D1 ITGA9 CACNA2D3 CACNA2D2 TCF7 ACTN4 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 PKP2 DSG2 EMD DSC2 CACNG6 SLC8A1 CACNG7 CACNG8 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 ACTB-1 LEF1 TCF7L2 TCF7L1 DMD DES RYR2 LMNA ACTN2 LAMA2 ITGA2B CTNNA1 CTNNA3 CTNNA2 ITGA10 ITGA11 ITGB1 CACNA1D ITGB5 ITGB4 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway SYT11 UBB;UBC UBA1 PINK1 MAPK14 MAPK12 MAPK13 MAPK11 CASP9 CASP3 SNCA SLC6A3 APAF1 CCNE2 CCNE1 PRKN PARK7 HTRA2 TH UBA7 CYCS-1 LRRK2 UBE2L6 UBE2J2 DDC UBE2J1 CASP7 UCHL1 ATXN2 CASP6 CASP2 GPR37 SEPTIN5 UBE2G1 UBE2G2 SNCAIP EPRS1 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260910%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine GCH1 MAOB DNAJC12 COMT PTS QDPR SPR AANAT DHFR2;DHFR TH PNMT MAOA ASMT PAH DBH MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260910%WP2006%HOMO SAPIENS miR targeted genes in squamous cell NRP1 PKM SDCBP PODXL GAS2L1 RHEB VCAM1 GNAI2 FGF2 AP2A1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A YWHAQ UBE2J1 MAP3K8 SLC38A1 TUBA1A CPNE8 VEZT ACAA2 SRPRB-1 ARF4-1 PWP1 DHX57 ARFIP1 CIAO2A HOXA7 POGLUT3 RARS1 ANXA2 TPM3 FNDC3B FBXW11 FNDC3A GOLGA7-1 DHX40 IDH1 RAB34 RAI14 SRSF9 TMED10 CBFB ADIPOR2 MRPL20 COMMD9 ANPEP SLC38A2 ATP6V1C1 ATP6V1F PEDS1-UBE2V1;PEDS1 SLC4A10 TBCA MOV10 NCL-1 HNRNPM CHMP2A ANP32B PICALM TRAM1 ADAR MAGT1 MRC2 SPTLC1 GFPT1 SH3BGRL3 TMED7 POLD2 TMED2-1 ELOVL5 ATRX SIGMAR1 PRPF40A CTDSP1 CSDE1 POM121;POM121C PXDN PTMA PNP-1 MTPN SEC23A TGFBR2 MRPS33 AKAP8 DNAJB1 POLR2C PPP1R7 SH3BP4 RTN4 PDLIM7 MPZL1 SLC12A2 GALNT7 TXNRD1 GALNT1 AP3D1 ARCN1 CUL4B TMEM59 SPCS3 FMNL2 GYS1 ATP6V0E2;ATP6V0E1 NEDD4 PDCD4 LAMTOR5 ATP2A2 BET1 SYNE2 TMEM43 HMOX1 TPM1 HES1 E2F3 HSD17B12 LAMC1 SMAD1 P4HA2 NF2 MET AXL PISD THBS1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260910%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway RACK1 PDGFD COL1A1 HIF1A COL1A2 IL11RA CCN2 PTPN11 AGT RRAS MAS1 MAP2K6 SMAD4 F12 IL6ST TGFBR1-1 JUND SMAD2;SMAD3 RAF1 SP1 IL11 ACE2 AGTR1 ACTA2 TGFB1 NOX4 MAPK1 TGFBR2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260910%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 LIPC PLTP GPIHBP1 GHR EPHX2 PCSK9 APOA1 LDLRAP1 USF1 CETP APOA2 APOB LPL LDLR LCAT PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260910%WP4917%HOMO SAPIENS Proximal tubule transport ABCG2 SLC5A5 SLC6A19 SLC16A10 ATP6V0E2;ATP6V0E1 SLC4A2 SLC4A4 AQP1 CA2 CA4 ATP6V1E1 SLC22A11 SLC13A3 ATP6V1G1 ATP6V0B SLC6A18 SLC36A2 SLC34A1 ATP1B1 SLC5A8 SLC7A8 SLC7A9 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A SLC22A6 SLC47A1 SLC20A2 SLC22A2 SLC1A1 SLC3A1 SLC3A2 ATP1A1 SLC5A2 SLC6A20 CLTRN ATP6V1H ATP6V0A4 ATP6V1D SLC12A4 FXYD2;FXYD6-FXYD2 SLC22A8 ABCB1 SLC22A7 SLC2A1 SLC26A6 SLC2A2 ABCC4 ABCC2 SLC9A3 SLC5A1-1 ATP6V1C1 ATP6V1F SLC7A7 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260910%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies JUNB CREBBP WNT7B CTNNB1 RB1 CDKN1A FNTA CEBPA CEBPB TCF7 SPP1 EMD TMPO LEMD3 CEBPD ACTB-1 AXIN1 LEF1 MAOA E2F1 HES1 HES5 TCF7L2 TCF7L1 CSNK1A1 CTSK APC TLE1 DICER1 RUNX2 BMP2 HMGA2 MAOB TARBP2 AGO2 ICMT CDK4 LMNA NOTCH1 ZMPSTE24 SREBF1 WNT10B TNFRSF11B SMAD2;SMAD3 KAT2B MSTN GSK3B HDAC1 NAP1L1 TGFB2 MYOD1 TGFB1 PPARG HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260910%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GNRH1 SST GHRH IGF1 OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260910%WP1434%HOMO SAPIENS Osteopontin signaling ITGB3 MAPK3 SPP1 ITGAV PLAU IKBKB CHUK RELA MMP9 NFKB1 MAP2K2;MAP2K1 MAPK1 MAP3K14 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260910%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ITGB3 ITGB2 MAPK9 ACTC1;ACTG2 SGMS1 LIMD1 MAPK8 ITGB8 STK3 SAV1 ITGB7 YAP1-1 ITGB6 MAP4K5 TEAD1 MAP4K3 WWTR1 TEAD3 MAPK10 MAP4K4 TEAD4 CTNNB1 MAP4K1 MAP4K2 ACTG1 MST1 LATS1 ACTA1 NF2 TEAD2 SRC BUB1B-PAK6;PAK6 PAK1 CDH1 CTNNA1 PAK5 PAK3 PAK2 PAK4 YWHAQ ACTB-1 ACTA2 ITGB1 ITGB5 ITGB4 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260910%WP4331%HOMO SAPIENS Neovascularization processes DLL4 MAPK9 MAPK3 NOTCH3 NOTCH1 MAPK8 NOTCH4 HIF1A SMAD1 ACVRL1 CXCR4 RELA CXCL12 JAG1 MMP9 TGFBR1-1 SMAD2;SMAD3 SMAD9 KITLG SMAD5 KDR FLT4 PDGFB EPHB2 AKT1 EPHB4 ANGPT1 REL RELB TGFB2 KIT TGFB1 TGFB3 NFKB1 MAPK1 NFKB2 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260910%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis MYD88 TRAF6 MAP3K7 MAPK8 MAPK14 ICAM1 IKBKB IKBKG CHUK IL6 IRF1 RELA ELANE GZMH;GZMB-1 TRAF3 CCL3L1;CCL3L3;CCL3;CCL18 NFKBIA LCN2 IL10 CXCL8 CCL4L2;CCL4L1;CCL4 VCAM1 IL1A TLR8 TLR7 TLR4 TNF IRAK1 REL IRF5 RELB IRF7 IRAK4 NFKB1 TAB2 NFKB2 TAB1 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 CUL1 HDAC2 STAT1 PARP1 STAT3 BTRC PARP14 PARP9 STAT6 RBX1 SKP1 DTX3L PARP11 PURINERGIC SIGNALING%WIKIPATHWAYS_20260910%WP4900%HOMO SAPIENS Purinergic signaling LPAR4 GNAI1 GNA11 LPAR6 GNAS-1 ADORA1 GNAZ PANX1 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 P2RY2 ADORA3 P2RY1 GNAI3 GNAT1 GNAI2 P2RY12 P2RY13 P2RY10 P2RY11 P2RY14 ADORA2A P2RX7 P2RX6 GNAO1 P2RX5 P2RX4 P2RX3 ADORA2B P2RX2 P2RX1 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway SIKE1 CXCL10 RNF125 TRAF6 MAP3K7 IRF3 IFNE MAPK9 IFNK NFKBIB NLRX1 TKFC DDX3X-1 CYLD MAVS SNW1 MAPK14 STING1 MAPK12 PIN1 MAPK13 TBKBP1 IKBKB ISG15 MAPK10 MAPK11 IKBKG CHUK RELA TRAF2 NFKBIA CXCL8 IFNG TNF IFNB1-4 TANK IRF7 ATG12-1 ATG5 MAPK8 CASP8 TRADD RIPK1 FADD CXCL12 MAP3K1 TRAF3 IFIH1 TBK1 OTUD5 CASP10 DHX58 TRIM25 AZI2 IKBKE NFKB1 DDX17 DDX58 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260910%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3R3 YAP1-1 TEAD1 PLCB3 PKN3 TEAD3 MOB1A;MOB1B PLCB4 TEAD4 LATS2 RHOA PKN2 GNAQ PKN1 PLCB1 LATS1 PLCB2 TEAD2 TRIO ROCK1 TSC2 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR TSC1 PIK3R2 PIK3R1 PTK2 PIK3CA MAPK1 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260910%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling SMAD2;SMAD3 MAPK9 LOXL2 MAPK8 BMPR1A LOXL4 MAPK14 BMPR2 LOXL1 LOX BMP1 SMAD4 TGFB1 GREM1 TGFBR1-1 TGFBR2 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260910%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions ITGB3 ITGAV HTR7 MAPK14 JAK3 ITGA2 IKZF2 LGALS3 LGALS1 CCN3 ROS1 TGM2 NKX6-2 STAT5A STAT5B EBI3 FOXO4 APOD GSDMD AREG MCAM CDC42 TMEM119 HEXB CCR8 CCR6 SSTR2 FAM20C CD47 CX3CR1 CNP SEMA3F AIF1 CCL1 KLRG1 TNF IL33 CCL20 IL10RB GALC MBP CD68 IL1RAP SOX9 CD4 NKX2-2 MOG CXCL2;CXCL3;CXCL1-1 OLIG1 IGF1 OLIG2 MYD88 IL1B PLP1 FOXO1-1 TGFBR1-1 TNFRSF1B CD86 CD274 CD80 IL2RG CTLA4 TGFB2 TGFB1 SOCS3 NFKB1 IL10RA NFKB2 SIRPA;SIRPB1;SIRPG RAC1 TGFBR2 IL2RA IL2RB PDCD1 JAK1 STAT1 STAT3 TYK2 IL6 IGF1R MMP9 IL10 OSM PDGFA IL18 NOS2 IL2 IL4 SPP1 IFNG PDGFRA IL12A TLR4 EGFR CASP1 NLRP3 VEGFA CD28 CD44 CXCL12 STAT4 SMAD2;SMAD3 IL12RB1 IL12RB2 FOXP3 P2RY12 FOXO3 TGFBR3 NKX6-1 CSPG4 PTK2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260910%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor SMAD2;SMAD3 RHO MAPK9 COL1A1 MAPK8 STAT3 MAPK10 CCN2 ENPP2 ACTA2 TGFB2 TGFB1 TGFB3 FN1 WNT SIGNALING%WIKIPATHWAYS_20260910%WP428%HOMO SAPIENS Wnt signaling MAPK9 WNT11 WNT7B CTNNB1 CCND3 CCND2 ROCK2 FOSL1 CCND1 MYC DKK2 DKK4 PPP3R1 SOX17 CER1 SERPINF1 CTNNBIP1 SFRP1 SFRP2 DAAM1 DAAM2 SFRP5 CTBP2 CTBP1 PORCN VANGL1 RYK-1 VANGL2 INVS KREMEN1 ROR1 SENP2 ROR2 PRICKLE2 PRICKLE1 PPP3CA CXXC4 PPP3CB NKD1 NKD2 PPP3CC WIF1 MAPK8 GPC4 NOTUM PLCB3 PLCB4 PLCB1 PLCB2 JUN FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 GSK3B NLK RAC1 MAP3K7 DKK1 SOST PLAU TPTEP2-CSNK1E;CSNK1E FRAT2 CSNK2A2 SFRP4 CSNK2B TCF7 DVL1 DVL2 DVL3 FZD10 AXIN1 CSNK2A1;CSNK2A3 LEF1 PRKCG NFATC3 TCF7L2 NFATC4 TCF7L1 WNT5B CSNK1A1 PRKCB APC PRKCA CAMK2B CAMK2D CAMK2A WNT6 WNT1 NFATC2 CAMK2G WNT2 RHOA WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 NFATC1 CHD8 WNT2B WNT16 LRP5 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes NR1H3 CYP7A1 IDI1 EBP CYP51A1 MVK NSDHL IDI2 SC5D MSMO1 DHCR24 HSD17B7 ACAT2 LBR TM7SF2 HMGCS1-1 PMVK SREBF1 ACOT2;ACOT1 FDFT1 MYLIP FDPS GGPS1 NR1H2 ELOVL3 ACSL3 LSS PLPP6 CH25H ABCG1 ABCA1 HMGCS2 CYP46A1 FADS2 ACSL1 SCD ELOVL4 MVD HMGCR ELOVL2 ELOVL5 CYP27A1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260910%WP623%HOMO SAPIENS Oxidative phosphorylation NDUFA9 DMAC2L ATP5PF NDUFA8 NDUFA7 NDUFA6 ATP5PD NDUFA5 NDUFA4 ATP5PB NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 GZMH;GZMB-1 NDUFA11 NDUFA10 ATP6AP1 ATP6AP2 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 NDUFB4 NDUFA4L2 NDUFB2 ATP5MC2 NDUFB1 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5ME COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases IDH2 D2HGDH MDH2 L2HGDH ADHFE1 ALDH7A1 ACY1;ABHD14A-ACY1 GCDH DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260910%WP2289%HOMO SAPIENS Drug induction of bile acid pathway SLC51A SLC51B CYP7A1 VDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 ABCC4 SLC10A1 ABCC2 NR1I3 NR1I2 NR1H4 BAAT ABCB11 SULT2A1-4 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 IL5 SIGNALING%WIKIPATHWAYS_20260910%WP127%HOMO SAPIENS IL5 signaling JAK2 RPS6KB2 MAPK3 JAK1 STAT1 STAT3 ELK1 PTPN11 RPS6KA1 MAPT RPS6KB1 KRAS GRB2 IL5RA CSF2RB JUN LYN SOS1 STAT5A STAT5B SYK BTK SHC1-1 SPRED1 RAF1 IL2 FOXO3 AKT1 PIK3CG GSK3B PIK3R2 RPS6 PIK3R1 GSK3A MAP2K2;MAP2K1 MAPK1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260910%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome C3-1 LMNB1 FNTA ICMT LMNA C5 LMNB2 RCE1 CFB CFD GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2276%HOMO SAPIENS Glial cell differentiation MSN MBP MAG TPPP PLP1 CNP GAP43 ALSTROM SYNDROME%WIKIPATHWAYS_20260910%WP5202%HOMO SAPIENS Alstrom syndrome DNM3 SMO VCP-1 RABL2A;RABL2B TFDP2 PTCH1 ACTN4 E2F4-1 IFT172 BLOC1S4 VCPIP1 HSPB11 IFT74 BLOC1S6 BLOC1S1 STX5 CEP192 SNAPIN PIFO IFT81 RFX2 IFT27 DTNBP1 RFX3 RFX1 TUBG1 ARMCX5-GPRASP2;GPRASP2 NSFL1C CEP19 RILPL1 MYO5B GPR161 ALMS1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2406%HOMO SAPIENS Cardiac progenitor differentiation DKK1 MAPK14 GATA4 KDR PDGFRA FGF2 SOX17 PAX6 MESP2 MESP1 MYLK3 KIT SCN5A MEF2C NRG1 SOX1 ISL1 IGF1 TNNT2 MYL2 ZFP42 MYH6 BMP4 POU5F1;POU5F1B ROR2 THY1 TBXT TBX20 TNNI3 ACTC1;ACTG2 NKX2-5 NOTCH1 IRX4 IGF2 TBX5 LIN28B NANOG;NANOGP8 LIN28A MIXL1 NODAL SOX2 BMP1 CXCR4 INS;INS-IGF2 ANPEP FOXA2 WNT3A NOG INHBA GSK3B NCAM1 TGFB1 SIRPA;SIRPB1;SIRPG NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260910%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging SIRT1 SIRT3 NAMPT FOXO1-1 HIF1A ROS1 PPARG PARP1 FOXO3 NFKB1 TFAM-1 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260910%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 EXOC8 RALBP1-1 RALA-1 YBX3 EXOC2 KRAS RAC3 NRAS HRAS RAC1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260910%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS ITGB3 ILK DKK1 ITGAV PODXL ITGA3 CTNNB1 CDKN1A CDKN1B CDH2 CDKN1C PLAUR DAG1 ACTN4 VIM TLR4 COL4A4 YWHAQ CR1L;CR1 PAX2 VTN DNM1 CAMK2B NPHS1 NOTCH1 NPHS2 WT1 MME PLCG1 WNT1 SCARB2 SMARCAL1 PTPRO MKI67 CLDN1 LAMA5 JAG1 SYNPO NCK1 KIRREL3 CTSV;CTSL TRPC6 KIRREL2 KRT8 CD2AP INF2 COL4A3 COL4A5 MYH9 IRF6 LMX1B UTRN CD151 LAMB2 PARVA FYN MYO1E LRP6 LIMS4;LIMS1 TLN1 FAT1 VCL AGRN AKT1 CD80 PCNA PLCE1 PTK2 TGFB1 ITGB1 LRP5 ITGB4 MRNA PROCESSING%WIKIPATHWAYS_20260910%WP411%HOMO SAPIENS mRNA processing XRN2 SRSF2 SRSF3 CD2BP2 SNRPF SREK1 SRSF5 SRSF6 HNRNPU SRSF7 SNRPA SNRPB DHX8 CSTF3 DDX1 CSTF2 SNU13 METTL3 PRPF8 PCBP2 DHX38 SNRPE-2 CPSF4 CPSF1 FUS DHX9 CPSF3 CLK4 CLK3 LSM2 CLK2 SRPK1 HNRNPL CLK1 LSM7 HNRNPK RNPS1 CLASRP HNRNPC HNRNPD SUGP2 SUGP1 SMC1A CELF1 CELF2 CELF4 SRP54 YBX1 PTBP1 SNRNP70 DHX15 DHX16 RBM5 CPSF2-1 RBM17 PRMT2 PRMT1 PTBP2 PRPF18 HNRNPH1 HNRNPH2 SNRPA1 DNAJC8 HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 SFSWAP RNMT SRSF1 DDX20 CSTF2T PPM1G NXF1 POLR2A U2AF2 TRA2B SPOP SNRPB2 SNRPG-2 SF3B1 SRSF10 SF3A3 RBM39 SF3A1 SRSF4-1 RNGTT SF3A2 HNRNPAB NUDT21 SNRNP40 PHF5A HNRNPA2B1 PABPN1-1 SRSF9 RBMX TMED10 HNRNPM NONO PRPF40A SFPQ-1 SUPT5H NCBP1 DICER1 NCBP2-1 U2AF1L5;U2AF1 HNRNPR EFTUD2 SNRPD2 CLP1 SNRPD1 PAPOLA SNRPD3 SRPK2 TXNL4A PSKH1 SNRPN PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism APOA4 IDI1 EBP CD36 CYP51A1 MVK NSDHL SC5D MSMO1 DHCR24 HSD17B7 DHCR7 ACAT2 LBR TM7SF2 HMGCS1-1 PMVK FDFT1 APOA1 MTTP FDPS SAR1B LSS NPC1L1 MGAT1 APOB LDLR ABCG8 ABCA1 ABCG5 FABP2 SQLE SLC27A4 DGAT1 MVD HMGCR STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260910%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling SCARB1 PRKAA1 FGF21 PRKAA2 PRKAG1 PRKAG2 PRKAG3 LDLR PRKAB2 PRKAB1 ACLY SP1 CREB1 ATF6 GSK3A IDI1 CYP51A1 SIRT1 HMGCS1-1 SREBF1 FDFT1 FDPS NR1H2 ACACA LPIN1 INS;INS-IGF2 LSS SAR1B FASN GPAM PPARGC1B SQLE MED15 YY1 SEC13 PRKACA-1 SREBF2 RBP4 KPNB1 SCD SAR1A INSIG2 INSIG1 RNF139 SCAP ACSS1 SEC23B AKT1 SEC31B MVD SEC31A MTOR CAMP HMGCR MBTPS1 SEC24B SEC24A MDH1 AMFR SEC24D-1 CDK8 NFYA-1 PIK3CA SEC24C MBTPS2 PPARG SEC23A LPL TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260910%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 INSR CACNA1A MAPK8 SLC2A2 PRKCZ TNF PIK3R5 IKBKB MAFA MTOR GK IRS1 ADIPOQ INS;INS-IGF2 SURF1 KCNJ11 PDX1 PHKA2 MAPK1 SOCS4 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260910%WP5031%HOMO SAPIENS Biotin metabolism including IMDs PC HLCS PCCB MCCC2 MCCC1 ACACA ACACB BTD PCCA ERBB SIGNALING%WIKIPATHWAYS_20260910%WP673%HOMO SAPIENS ErbB signaling EIF4EBP1 CBLB NCK2 MAPK9 NRG2 MAPK3 EREG BTC MAP2K4 NRG3 NRG4 PLCG2 HBEGF ERBB3 BAD ERBB4 ABL2 ELK1 GAB1 PDPK1 MAPK10 CDKN1A CDKN1B RPS6KB1 CBL GRB2 SOS1 CRK STAT5A STAT5B SHC4 EGF SHC1-1 SHC2 AREG SRC CCND1 TGFA PAK1 MYC ERBB2 PAK3 PAK2 PAK4 TP53 MDM2-2 SOS2 EGFR ABL1 PRKCG NRG1 PRKCB PRKCA RPS6KB2 CAMK2B CAMK2D NRAS MAPK8 CAMK2A PIK3R3 HRAS CAMK2G MAP2K7 KRAS FOXO1-1 JUN NCK1 CRKL BUB1B-PAK6;PAK6 RAF1 ARAF PAK5 PIK3CD AKT2 BCL2L11 AKT3 PIK3CB AKT1 SHC3 MTOR GSK3B PIK3R2 BRAF PIK3CA PIK3R1 PTK2 MAP2K2;MAP2K1 MAPK1 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP3K7 MAPK9 MAPK3 MAP2K4 MAPK8 MAPK14 PARP1 MAPK12 TNKS MAPK13 MAP3K21 MAPK10 DUSP1 PARP14 MAPK11 MAP3K12 MAP3K9 MAP2K7 MAP2K6 MAP2K3 MAP3K1 MAP3K10 RAF1 MAP3K11 ARAF ATF4 MAP3K5 MAP3K8 BRAF MAP2K2;MAP2K1 MAPK1 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260910%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism SLC2A4 PYY GCG FFAR2 FFAR3;GPR42 PPARD ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260910%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway IRF3 IL1B RXRA GUCY1B1 IKBKB MMP1 KEAP1 IKBKG CHUK SLC7A11 IL6 GUCY1A2 GUCY1A1 RELA MMP3 NFKBIA GCLC CXCL8 GSTA3;GSTA5;GSTA1;GSTA2 TMPRSS2 GCLM HMOX1 NQO1 IL12A PRKG2 TNF NFE2L2 CCL13;CCL2 ACE2 NFKB1 NOX1 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260910%WP5124%HOMO SAPIENS Alzheimer 39 s disease ITPR2 GAPDH-1 HSD17B10 IKBKB CHUK RELA APP CALML6 CALML3 CALML4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 ATG14 PSMC2-1 ATG13 DKK2 DKK4 VDAC3 ULK2 ULK1 VDAC1 ATF6 TNF ATF4 APH1A NCSTN GRIN2A PPP3R1 AXIN2 APH1B NRBF2 XBP1 EIF2AK3 EIF2AK2 GRIN2C GRIN2B GRIN2D ATG2A NOX4 CALM1 CALM2 NOX1 ATG2B IDE SLC25A4 RYR3 TUBA1C IL1B PPP3CA PPP3CB TUBA1A PPP3CC PSENEN MAPK8 MME BACE1 CASP8 PSMA5 PSMA6 PLCB3 PSMA3 PLCB4 FADD PSMA4 PSMA1 MAPT TNFRSF1A PLCB1 PLCB2 MAP2K7 TUBB3;TUBB6 PSMA7 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 DDIT3 PSMB2 PSMB3 PSMB1 APBB1 TUBB4B RAF1 CALM3;CALM1 GRIN1 FZD1 PSMA2-1 PSMC5 FZD3 PSMC6 PSMC3 WNT3A PSMC4 WNT5A WNT7A PSMC1 CDK5R1 IRS4 VDAC2-1 WNT3 KIF5C LRP6 AKT2 KIF5B AKT3 KIF5A AKT1 TUBB1 MAP3K5 MTOR CYBB TUBA4A ERN1 ADAM17 PPIF PPID GSK3B RTN3 PIK3R2 PSMD12 PIK3R1 PSMD14 PSMD13 PSEN2 ITPR1 MAP2K2;MAP2K1 CACNA1D GPR83 MAPK1 ITPR3 CACNA1C PSEN1 CACNA1F KLC1 AGER MAPK3 DKK1 RTN4 KLC4 KLC3 KLC2 ATG101 NAE1 BAD CACNA1S TUBA3E;TUBA3C-1 EIF2S1 SEM1 TUBB4A;TUBB;TUBB8B;TUBB8 TPTEP2-CSNK1E;CSNK1E MCU TUBA8 ATP2A3 IL6 ATP2A2 ATP2A1 FRAT2 RB1CC1 TUBB2B;TUBB2A TRAF2 CSNK2A2 WIPI1 SFRP4 WIPI2 CSNK2B SLC25A5 SLC25A6 BECN1 TUBAL3 DVL1 BECN2 DVL2 AMBRA1 SNCA DVL3 NOS2 ADRM1 SLC25A31 IL1A FZD10 APC2 AXIN1 CSNK2A1;CSNK2A3 CSNK1A1 WNT5B APC PIK3R4 PIK3R3 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 FZD5 FZD7 FZD6 FZD9 FZD8 ARAF CAPN2 CAPN1 WNT2B PIK3CD PIK3CB BRAF WNT16 PIK3CA PIK3C3 LRP5 MAPK9 WNT11 WNT7B MAPK10 CTNNB1 CASP9 CASP3 APAF1 CYCS-1 BID CDK5 FAS IRS1 IRS2 INS;INS-IGF2 CHRNA7;CHRFAM7A NOS1 NFKB1 APOE INSR CSF1 CASP7 ADAM10 NRAS HRAS GNAQ KRAS PTGS2-2 LRP1 LPL NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260910%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease MAPK9 PRKAA1 RXRA IKBKB UQCRB UQCR11 CEBPA UQCR10 BBC3 RELA UQCRQ PRKAA2 UQCRC1 PRKAG1 PRKAG2 UQCRFS1 CYC1 UQCRC2 PRKAG3 CASP3 CDC42 PRKAB2 PRKAB1 VCAM1 TNF ATF4 CYCS-1 PPARA XBP1 EIF2AK3 BID GSK3A IL1B NR1H3 MAPK8 CASP8 FAS BAX SREBF1 TNFRSF1A IRS1 IRS2 ADIPOQ LEPR JUN INS;INS-IGF2 ADIPOR1 DDIT3 ADIPOR2 NDUFA11 NDUFA10 NDUFA13 MAP3K11 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB9 NDUFB8 AKT2 NDUFB7 AKT3 NDUFB10 AKT1 NDUFB6 MAP3K5 NDUFB5 CCL13;CCL2 NDUFB4 NDUFA4L2 ERN1 NDUFB2 NDUFB1 GSK3B CYP2E1 PIK3R2 PIK3R1 NDUFC2;NDUFC2-KCTD14 TGFB1 NDUFV3 SOCS3 NDUFV2 NFKB1 NDUFV1 RAC1 NDUFA9 IL6R NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 NDUFAB1 EIF2S1 NDUFS5-1 LEP NDUFA12 IL6 COX6A1 COX6A2 NR1H4 SDHC SDHD TRAF2 SDHA COX6B2 SDHB COX6B1 NDUFB11 COX7A2 COX7B2 CXCL8 COX7B COX4I1 INSR COX4I2 COX7C MLX COX8A COX8C IL1A COX7A2L-1 NDUFB3 COX5B COX5A MLXIP SMAD7 PKLR COX6C ITCH CASP7 BAK1 PIK3R3 BCL2L11 PIK3CD PIK3CB FASLG PIK3CA JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260910%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells SOCS2 JAK2 IL6R CDK4 NRAS STAT1 HRAS STAT3 GHR IL6 KRAS CCND3 CCND2 STAT5A STAT5B EPO RPTOR IFNGR1 IFNGR2 IFNG MLST8 AKT2 EPOR AKT3 AKT1 MTOR PRL SOCS1 CISH PRLR FOXM1 SOCS3 AKT1S1 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260910%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease RAF1 MAPK3 CREB1 RPS6KA5 GRM1 HRAS ELK1 HTT EGFR CASP7 NTRK2 BDNF EGF MAP2K2;MAP2K1 CASP3 MAPK1 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260910%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis GNA13 GNA12 RHOA ARHGEF1 TBXAS1 TBXA2R PTGS1 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260910%WP259%HOMO SAPIENS Nifedipine activity PTK2B PCNA SOD1 KDR BDKRB2 MAP2K2;MAP2K1 MAPK1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260910%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia MYC ABCG2 PDGFRA PDGFRB FOXO3 CSF1R GAB2 CDKN1B NOP2 BCR ABL1 SPRED2 PIM2 KIT SKP2 FLT1 PIM1 GADD45A ABCB1 LYL1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADM HADH ACADS EHHADH-1 ACSL1 SCP2 CPT1A PECR ACADVL ECI1 ACSL3 ACSL4 ACSF2 HADHA ACADL CPT2 SLC25A20 FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260910%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 APOA5 LMF1 LIPC APOC2 PLTP GPIHBP1 APOA1 CETP LRP1 SEL1L APOA2 LPL LDLR LCAT CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260910%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism JAK2 TRAF6 DKK1 SP7 SOST ATG101 LEP IL6 RB1CC1 CLOCK TNFSF11 PRKAA2 CALCA BECN1 NR1D2 AMBRA1 ATG13 HMGB1-1 BHLHE41 ULK1 LAMP2 IL3 CSF1 SERPINF1 ATG3 MAP1LC3B2;MAP1LC3B-1 ATG10 ARNTL ATG12-1 SQSTM1 IGF1 ATG7 CTSK ATG5 BMP4 RUNX2 BMP2 ATG16L1 ARHGAP4 FYCO1 MEPE ATG4C NOTCH1 CTF1 PER1 SEMA3A CHRD EFNB2 DRAM2 CTHRC1 TRAP1 VCP-1 SEMA4D RORB BMP5 BMP3 PLEKHM1 BMP6 WNT10B SMAD1 SMAD4 BCL2 TNFRSF11B SMAD9 SMAD5 TNFRSF11A NPAS2 NFATC1 WNT5A BMPR2 AKT1 MTOR MAP1LC3A BHLHE40 WNT16 PTH TGFB1 PIK3C3 LRP5 CRY1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260910%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway SLC2A1 PDHA1 PRKAB1 LDHA PRKAA1 HIF1A PDK1 TP53 NFE2L2 KEAP1 CUL3 SLC11A2 RPS6 VEGFA PDHB ACACA PRKAG1 ACACB EGLN1 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260910%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer ERBB3 VAV3 CDKN1A PKN1 CDKN1B RPS6KB1 APP JUND APOE CUL1 PAK2 VIM F2R SMAD7 TNF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A AXIN1 HSPD1 PTK2B ABL1 CASP7 NRG1 SQSTM1 IL7R YBX3 SERBP1-1 IER3 HELLS TRAF1 CARD14 TNFRSF21 BEX3 ETS1 CUL5 RNF7 NET1 GCLC BCL3 CTNNA1 BIRC5 NQO1 ANXA5 RIPK2 AKT1 HSPB1 ERN1 THBS1 HDAC1 HSPA5 PTK2 SOCS3 NFKB1 MAPK1 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260910%WP5546%HOMO SAPIENS 22q11 2 distal CNV UBA6 CUL2 CABP1 AK8 SNRPF CD79B CD79A SDF2L1 CWC15 TDRD3 RPS29 SNRPB SNW1 RPS20 HYOU1 AQR RPS21 RPS24 RPS23 ELOC-1 PRPF8 IQUB ELOB ARIH1 SNRPE-2 TOP3B CCDC116 BUD31 NME5 CBL PLRG1 YDJC CANX RBM22 LRP4 RSPH9 PPM1F RNF113A CHEK1 RPS15A RPS3 PAK1 PRAME RPS2 RILP UGGT1 PAK2 PPIL2 CDC5L RSPH3 XAB2 YPEL1 FAU CAMK1 PPIL4 ATF6 CDC16 PPIL6 DHX16 TP53 MDM2-2 SOX9 XBP1 RBX1 SNRPA1 SF3B4 SF3B5 SF3B2 SF3B3 RPS27A UBA1 SNRPB2 SNRPG-2 SF3B1 UBE3A SF3A3 SF3A1 SF3A2 SNRNP40 PHF5A RPS6 HSPA5 CALR-1 PPIB MAPK1 DNAJB11 RACK1 NEDD4 PRKN BCR HSP90B1 CAMK2A RNF19B GNAZ PPIL1-1 RPS15 RPS14 RPS17 VPREB1 RPS16 PTPA RPS19 RPS18 CWC22 ROPN1L RPS11 RPS10 RPS13 CAMK4 RPS12 RSPH6A SRRM2 PDIA2 EFTUD2 RPS9 SNRPD2 ZNF280D;ZNF280A RPS7 SNRPD1 RPS8 RPS5 SNRPD3 DNAJB13 RPSA CRNKL1 PDIA4 IGLL5;IGLL1 RAB36 ERP29 PPIE DYDC1 SNRNP200 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260910%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260910%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER3 CYP19A1 MAPK3 NRAS HRAS PLA1A MMP1 KRAS PTGS2-2 ESR1 SRC PIK3CD AKT2 AKT3 PTGES2 PIK3CB AKT1 PTGER4 PIK3CG PTGER2 EGFR BRAF PIK3CA MAPK1 PTGER1 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260910%WP3645%HOMO SAPIENS NAD biosynthetic pathways IDO1 PARP1 TNKS SIRT4 PARP4 SIRT5 NADSYN1 SIRT1 BST1 SIRT2 TNKS2 SIRT3 NAPRT SIRT6 NMNAT1 NAMPT QPRT CD38 ACMSD TDO2 PARP2 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260910%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR2A IL1B NEK7 RAPGEF3 PRKAR1B PRKAR1A NLRP3 PRKACB-1 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260910%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC1A1 SLC3A1 SLC36A2 SLC3A2 SLC6A20 CLTRN SLC7A7 SLC7A9 SLC6A19 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260910%WP3924%HOMO SAPIENS Hfe effect on hepcidin production BMP6 HFE HJV ID1 TMPRSS6 HAMP SMAD7 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260910%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A1 FGFR4 MAPK3 CYP7A1 ABCB11 FXR1-1 FGF19 SLC10A2 ABCG8 MAPK1 LDLR ABCG5 MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260910%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CCR2 CTCF MSMP SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260910%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H4C6 UBE2C MAPK3 MAPK7 STAT3 CDKN1A CDKN1B FOS IL6 UBA52 CDC23 CDC27 RELA ANAPC7 CCNA1 ANAPC4 ANAPC5 CEBPB ANAPC1 CXCL8 ANAPC2 ANAPC10 ANAPC11 IL1A CDKN2D CDKN2B CDKN2C CDC16 CCNA2-1 H2BC21 FZR1 EHMT2 UBE2D1 EHMT1 H2AC14 CDC26 RPS27A H3-3A UBB;UBC H2AC4 CDK6 H2AZ2;H2AZ1 H2AJ ANAPC15 CDK4 ANAPC16 CDK2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC5 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 UBE2S H2AC20 H2AB2;H2AB3;H2AB1 RPS6KA3 RPS6KA2 RPS6KA1 JUN IGFBP7 H4-16 CDKN2A UBE2E1 NFKB1 MAPK1 H4C1 ATM SIGNALING%WIKIPATHWAYS_20260910%WP2516%HOMO SAPIENS ATM signaling RAD50 MAPK9 RAD51 CDK2 CDK1 ATF2 ATM MDC1 RIPK1 RAD9A TP53BP1 IKBKG CRADD CDKN1A MDM4 MRE11 BRCA1 PIDD1 JUN CHEK2 CHEK1 TLK1 NBN SMC1A CDC25C CDC25A CREB1 CCNE1 TP53 MDM2-2 TP73 CCNB1 ABL1 CASP2 BID GADD45A POLYOL PATHWAY%WIKIPATHWAYS_20260910%WP690%HOMO SAPIENS Polyol pathway KHK ALDOB AKR1B1 SORD 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome ABCC6 DCTN6 PLAG1 DCTN4 ACTR1A ACTR1B PLAGL1 KIAA0753 MYH11 BMERB1 DCP2-1 DISC1 OFD1-1 ABCC1 NDE1 MARF1 DCP1A CEP20 ACTR10 PAFAH1B1 DCTN1 RAPGEF4 PLK1 GATA3 RAP1A VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260910%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism SCARB1 RXRA CD36 CYP26A1 ADH4 ADH1C;ADH1B;ADH1A ALDH1A1 RPE65 SDR16C5 RDH12 NPC1L1 RXRB AWAT2 CYP26B1 ABCG8 ABCG5 LRAT RXRG BCO1 RBP4 RARG CRABP2 RDH8 DGAT1 RETSAT CRABP1 RLBP1 RDH10 BCO2 DHRS3 ALDH1A3 RBP7 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 RBP2 RBP1 SULT2B1 RARA RARB RDH5 ALDH1A2 CYP2E1 LPL MAPK1 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260910%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome BBS4 NDC1 NUP214 NUP210 NUP133 NIPA1 TACR3 NIPA2 SNURF NUP93 NUP50 FEZ1 FEZ2 NUP54 NUP98 OCA2 NUP205 SLC45A2 RB1 SEH1L NUP58-2 POMC DLX5 TUBGCP2 FSHB ATP10A AAAS LHB NUP160 NHLH2 NUP85 NUP42 CCND2 TPR NDN NUP43 NUP88 CGA MSX1 RAE1 CCND1 RANBP2 NUP155 NUP153 TYR GNRH1 OXT-1 KISS1 TUBGCP5 NUP35 MKRN3 CDC6 TUBGCP6 TUBGCP3 CDKN2B TUBGCP4 CDKN2C NUP37 TP53 MDM2-2 GABRB3 E2F1 GABRG3;GABRG2 GABRD CDK6 CYFIP1 GABRA5 CDK4 RNF8 FMR1 GABRG1 GHRH GHRL PRKCZ UBE3A MDM4 NGF EIF4E UBE2N BDNF INS;INS-IGF2 MAGEL2 SEC13 PCSK1 CDKN2A NUP107 NUP188 SNRPN POM121;POM121C AHCTF1 GLE1 GABRR3 GABRR2 GABRR1 HERC2 NUP62 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GNT5 B3GALT1 B4GALT3 ARSA GBA GALC GBA2 UGT8 UGCG NEU3 NEU4 GAL3ST1 ST3GAL5 B4GALNT1 A4GALT B4GALT6 A3GALT2 GLA B4GALT4 B4GALT5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260910%WP4549%HOMO SAPIENS Fragile X syndrome CPT1A RHEB APP DAG1 HOMER1 SRC PRKAR1A CREB1 CLTC CAMK1 CLTA AP2A1 KCND2 GRIN2A AP2M1 MKNK1 GRIN2B DNM1 DNM2 AP2B1 ALDH5A1 PPP3CA GAD1 PPP1CA ABAT GRM5 CLTCL1 AP2S1 PLCB1 EIF4E BDNF RAF1 SLC6A1 GRIN1 TSC2 FYN AKT1 MTOR ITPR1 MAP2K2;MAP2K1 AGAP2 MAPK1 MECP2 GAB1 PTPN11 RPS6KB1 GRB2 MMP9 SOS1 SHC1-1 PTEN MAP1LC3B2;MAP1LC3B-1 GABRB2 GPHN GABRG3;GABRG2 GABRD CYFIP2 EIF4A1 SH3GL3 PRKCA GABRA1 GRIP1 DICER1 DEPTOR SH3GL1 CAMK2B TARBP2 CYFIP1 EPHA4 GRIA1 AGO2 GRIP2 EEF1A1 ALDH3A2 FMR1 TBC1D7;TBC1D7-LOC100130357 HOXB8 PLCG1 CAMK2A TELO2 GRIA2 RAP1GAP GRM1 EIF4EBP2 SLC16A1 SYNGAP1 ARHGAP32 NF1 EIF4G1 PPP2R5B ABCD3 KCNC1 TECR ARC CLTB DLGAP3 DUSP3 SHANK1 KRAS TTI1 PICK1 DLG4 AKAP5 CNR1 EPS8L1 PTPN5 HCN1 ARAF RPTOR PRKACA-1 MLST8 PDK1 CAMK4 MAP1B PIK3CB TSC1 NTRK2 CDKN2A BRAF AKT1S1 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation VLDLR PAFAH1B3 PAFAH1B2 NDEL1 PAFAH1B1 TUBA1A CLIP1 DYNC1H1 RELN NUDC DCX METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260910%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260910%WP4521%HOMO SAPIENS Glycosylation and related congenital defects DPAGT1 ALG8 ALG9 B4GALT1 ALG6 TUSC3 MPI PMM2 SRD5A3 ALG2 MAGT1 ALG14 ALG3 DOLK MOGS ALG12 ALG1 ALG11 DPM1 GMPPB DPM3 MGAT2 MPDU1 DPM2 JOUBERT SYNDROME%WIKIPATHWAYS_20260910%WP4656%HOMO SAPIENS Joubert syndrome TCTN2 BBS4 CSPP1 TCTN1 BBS9 BBS7 CEP97 CEP290 CC2D2A BBS5 ARMC9 RPGRIP1L TMEM138 RP2 TMEM216 ANKS6 CEP104 ARL3 ARL2 RAB8A ARL13B TMEM67 MRE11 INPP5E RHEB NPHP1 MYO6 PDE6D NPHP3 FLNA PDE6B PDE6A AHI1 PCNT PIBF1 NEK8 BBS2 DVL1 BBS1 RAB3IP MYO5A MKS1 DVL3 CPLANE1 TMEM231 NIN TTC8 TMEM17 KIAA0586 TMEM237 UNC119 B9D1 CEP41 B9D2 ATF4 SHH INVS RAD50 PARP1 ATM RHOA CETN2 OFD1-1 MTOR ZNF423 CETN1 CEP120 CEP164 CCP110 ARR3 KAT5 TCTN3 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260910%WP2328%HOMO SAPIENS Allograft rejection C3-1 IL2RA C1QC PRF1 STAT1 IL12B LOC110384692;C4A;C4B_2;C4B IL13 CASP9 CSNK2A2 CASP3 IL10 C5 CXCL8 C1QB IL2 IL4 IL1A VIM IFNG C2 CD40LG PDGFRA IL12A C6 C7 C9 HLA-DPB1-1 TNF CD55 IL5 CXCL13 C8B C8A HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CXCL9 HLA-DOA LRRK2 HLA-DOB GABPA HLA-DPA1 HLA-DRA BHMT2 CASP7 CXCR5 HLA-DQB2;HLA-DQB1 PECR HLA-DMB VEGFA CCL19 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD28 HARS1 CCL21 COL5A1 CXCL11 ABCB1 IL17A IL1B GDNF CASP8 FAS PRKCZ IL21 IL22 CXCL12 GZMH;GZMB-1 HLA-DMA CD40 FOXP3 CD86 CD80 FASLG AGTR1 CTLA4 TGFB1 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260910%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway EIF4EBP1 MAPK9 MAPK3 BAD MAPK14 STAT3 MAPK12 MAPK13 IKBKB PTPN11 MAPK11 CTNNB1 IKBKG CHUK DOK2 MMP2 RELA GRB2 CASP9 SOS1 CRK STAT5A STAT5B NFKBIA FN1 SRC PAK1 MYC NOS2 ERBB2 TP53 EGFR CASP7 MSH2 RS1 TNIP3-2 RASA1 ANGPTL1 GRB14-1 GRB7 RAD51 TIE1 TNIP1 TNIP2 NRAS MAPK8 YAP1-1 BAX HRAS KRAS FOXO1-1 NCK1 STMN1 NOS1 BIRC5 ANGPT4 AKT1 PXN ANGPT2 ANGPT1 TEK PIK3CA PIK3R1 PTK2 ITGB1 NFKB1 MAPK1 RAC1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260910%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HPSE2 IDUA HEXA GLB1 GNS SGSH GALNS HYAL1 HYAL2 HYAL4 IDS NAGLU HPSE GUSB ARSB IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260910%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL6 BLVRB JAK1 IL1A STAT2 HMOX1 BLVRA STAT1 STAT3 IL10 IL10RA IL10RB NUCLEAR RECEPTORS%WIKIPATHWAYS_20260910%WP170%HOMO SAPIENS Nuclear receptors ROR1 NR1H3 RXRA AR NR2C2 VDR PPARD NR5A1 NR2F6 NR1I3 NR1I2 NR2F2 NR2E1 NR3C1 NR1H2 RORC ESRRA RORA ESRRB NR2F1 THRB NR0B1 THRA RXRB NR4A2 ESR1 NR4A1 NR1D2 NR5A2 RXRG HNF4A ESR2 PGR RARG RARA PPARA RARB PPARG CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260910%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis ITPRIP CABIN1 LCK CD8A HDAC2 PPP3CA CD8B;CD8B2 PPP3CB MEF2D PPP3CC CAPN2 PLCG1 EP300 NFATC2 CD4 ATP2A1 HDAC1 ZAP70 CALM1 NR4A1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members DVL2 CUL1 DVL3 TNK2 TNK1 PLK1 PARP10 PARP1 BTRC CTNNB1 AXIN1 RBX1 SKP1 APC DVL1 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260910%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CUL2 ELOB RBX1 ZYG11B UBA3 NAE1 CBFB ELOC-1 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260910%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL1B IL12B ZBTB16 IL6 IL22 IL13 RORC RORA IL25 TBX21 AREG IL18 IL9 IL4 IFNG IL23A ID2-1 IL12A GFI1 EOMES TNF IL33 TSLP IL5 BCL11B GATA3 IL15 TOX HNF1A IL7 AHR NFIL3 IL17A FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260910%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 APOA5 LMF1 LIPC APOC2 DGAT2 PLTP GPIHBP1 FAS ACSS1 PDIA2 GCK APOA1 MTTP CETP LRP1 SEL1L GCKR APOA2 LPL LDLR LCAT EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260910%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR3B POLR1A ILK POLR2C ERCC3 POLR3D POLR1B POLR3E POLR1D POLR2A TAF7 POLR1E TAF6 ERCC2 POLR3H TAF5 POLR3K CDK7 MNAT1 GTF2H2C;GTF2H2C_2;GTF2H2 GTF2A2 CCNH GTF2B TAF9 GTF2E1 GTF2E2 POLR2B POLR2E POLR2F POLR2G POLR2H POLR2I TBP GTF2H1 TAF12 GTF2H3 TAF13 GTF2F2 GTF2H4 POLR2J;POLR2J2;POLR2J3 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP5414%HOMO SAPIENS IDO metabolic pathway IDO1 GOT2-1 IFNG AADAT KMO TDO2 KYNU KYAT3 TNF KYAT1 IDO2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260910%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2A13;CYP2A6;CYP2A7-1 CYP2D6;LOC107987479;LOC107987478-1 FMO1 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 FMO3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A1 CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2A1-4 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260910%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex LCK CD8A CD8B;CD8B2 FYN CD3G PRG3 CD3E CD2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 NKRF CD247 CD4 LBP MMP25 IL6 HLA-DRA CRP IGLL5;IGLL1 ZAP70 CXCL8 KALLMANN SYNDROME%WIKIPATHWAYS_20260910%WP5074%HOMO SAPIENS Kallmann syndrome GNRH1 MYRF FGFR1 CHD7 ASCL1 PROK2 PTPN11 AKT1 PLXND1 FRS2 SEMA3E ANOS1-1 TMEM98 OTX2 LHB FGF8 GRB2 NEUROG1 PIK3CA OLIG2 PROKR2 MAP2K2;MAP2K1 MAPK1 SOX10 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260910%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADM HADH ACADS EHHADH-1 ACSL1 SCP2 CPT1A PECR HADHB-1 ACADVL SLC22A5 ECI1 ACSL3 ACSL4 ACSF2 HADHA ACADL CPT2 SLC25A20 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260910%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts CHST11 CHST12 CHST13 CHST14 HS3ST1 HS3ST2 CHPF XYLT2 HS2ST1 XYLT1 EXTL2 EXTL1 DSE CHST15 CHSY3 EXTL3 CSGALNACT1 CHPF2 B3GAT3 HS6ST1 HS3ST3B1 B3GAT2 HS6ST2 GLCE HS6ST3 B3GAT1 CSGALNACT2 NDST2 B3GALT6 NDST1 EXT1 CHST7 EXT2 CHSY1-1 NDST4 UST NDST3 B4GALT7 HS3ST3A1 CHST1 CHST3 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260910%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome TRAF6 HDAC3 MAPK3 TRAF2 ESR1 MSN PTEN PARP4 TP53 DOC2A CCT6B PAGR1 SPN PPP4R1 IGFBP3 PPP4R2 QPRT PPP4R4 CCT3 CCT2 UNC13A PPP4R3A PPP4R3B KIF22 TLCD3B ASPHD1 TCP1 KCTD13 TMEM219 ZG16 ALDOA EZR KMT2D INO80E PAXIP1 KMT2C MVP MAZ CASP8 GDPD3 SEZ6L2 CORO1A HIRA PPP4C CDIPT HIRIP3 CCT8 CCT7 PPP2R5D CCT5 CCT4 BPTF IGBP1 C16orf92 MAP2K6 PRRT2 NR3C1 MAP2K3 TBX6 C16orf54 CCT6A TAOK2 CCDC6 PPP2CB;PPP2CA YPEL3 UNC13B SIAH1 PCNA REL PPP2R1A PPARG NFKB1 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260910%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB AJUBA TRAF6 IRAK1 UBE2N IL1A SQSTM1 PRKCZ NFKB1 TIFA UBE2V1 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA1 SLC33A1 ST8SIA3 B3GALT4 ST8SIA5 ST3GAL1 ST3GAL2 ST6GALNAC6 B3GALT1 FUT1 ST3GAL5 B4GALNT1 A3GALT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260910%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAF1 ARAF MAPK3 NRAS RAB5B RAB5C PDCD6IP RAB27A HRAS RRAS2 MRAS HGS RAB5A RRAS HNRNPH1 KRAS BRAF MAPK1 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence HPGD ALOX15 GSTP1 ALOX12 LTC4S PTGS1 DPEP1 ALOX5 LTA4H PTGDS GSTM4 PTGIS EPHX2 PLA2G4A CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX15B TBXAS1 PTGS2-2 GGT1 FADS2 FADS1 CYP2D6;LOC107987479;LOC107987478-1 FPR2 CYP2C9;CYP2C19 GPR32 ELOVL2 ELOVL5 CYP2E1 PTGES CAMKK2 PATHWAY%WIKIPATHWAYS_20260910%WP4874%HOMO SAPIENS CAMKK2 pathway PFKFB2 TRPV4 GATM SPIRE1 MS4A3 HK2 OASL CCR9 CTSE ERMAP GIT1 GALNT9 MAMDC2 HK1 C1QTNF12 ATP10D TSPAN33 SLC25A21 EP300 AHSP TMEM176B IRGC KLF1 SLCO3A1 RHAG RELA ARHGEF7 CCND1 PAK1 VCAM1 SMC1A FAM20C KDR CDC25A CREB1 ULK1 CAMK1 TNF CCNE1 IL15 DNM1L CXCL11 CALM1 PARP1 SREBF1 ACACA FASN RAF1 CDH1 NOS1 NLRP1 MAF CCL5 MTOR MAP1LC3A RPS6 ASNS MAPK1 RAC1 MAPK3 ICAM1 KEAP1 RPS6KB1 AQP1 CAMKK2 ABCA1 HMOX1 HDAC4 NFE2L2 HFE PFKFB3 MAP1LC3B2;MAP1LC3B-1 CD28 SQSTM1 S100A8 SLC2A1 RASGRP1 TBXT HIF1A NFATC2 SIRT1 GCK SLC2A4 RPTOR WDR35 CAMK4 EPOR PCK2 CHRM3 CPOX TSC1 IFI44L ATP1B2 MID1 SPINT1 STIM1 HMBS CRTC2 NEDD4L CYB5R3 TSPAN8 SLC38A5 FIS1 WFS1 PLAC8 SELL AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260910%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy CACNA1F ITPR2 PRKAA1 SERPINE1 MPO CACNA1S PLAU PRG3 CCN2 FGB FGA MCU FGG IL6 RYR1 ATP2A1 MCUB SGCA MMP2 SCX GLI1 CASP9 DAG1 PRKAA2 TOMM20 MMP9 TRPC3 TRPC1 SLC25A5 CACNA2D1 TRDN NFKBIA IL10 ORAI1 CASQ1 TNNI1 SARAF CACNB1 DTNA CACNB2 NOS2 GP2 SSPN SNTB1 SPP1 IL1A CACNG1 VDAC1 TNF HSPA9 NOX4 DMD IL1B PLA2G2A-1 CAMK2D PLA2G4A SMAD4 ELANE TGFBR1-1 TRPC6 SMAD2;SMAD3 CAPN3 CYBB AGTR1 SIGMAR1 PPIF STIM1 FKBP1A TGFB1 ITPR1 NFKB1 TGFBR2 ITPR3 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260910%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GLUD1;GLUD2 SLC25A12 GOT2-1 SLC25A22 SLC25A13 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260910%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells PRKCA PRKCQ NLRP7;NLRP2 CSF2 IFNG ELF3 LCP2 PLCG1 TYROBP LAT FYN TNF VAV1 PTPN2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SYK ITPR1 PTPN6 RAC1 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260910%WP4758%HOMO SAPIENS Nephrotic syndrome NPHS1 LMNA ZMPSTE24 NPHS2 WT1 PODXL ITGA3 CUBN SCARB2 SMARCAL1 PTPRO SYNPO CYP11B1;CYP11B2 TRPC6 ACTN4 CD2AP INF2 COL4A3 COL4A5 MYH9 LMX1B CD151 LAMB2 YARS1 PMM2 MYO1E ARHGDIA TTC21B PDSS2 COL4A4 GPC5 EMP2 WDR73 COQ6 ALG1 ARHGAP24 PAX2 ANLN CTLA4 COQ2 APOL3;APOL4;APOL1;APOL2 PLCE1 E2F3 ITGB4 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260910%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway PRKCA PRKCQ CSF2 IFNG LCP2 PLCG1 TYROBP LAT FYN HRAS TNF VAV1 PTPN2 GRB2 CD34 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SYK ITPR1 PTPN6 RAC1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260910%WP34%HOMO SAPIENS Ovarian infertility MSH5 DMC1 CYP19A1 INHA RAD51 ZP2 CDK4 FMR1 ATM VDR NR5A1 CDKN1B CCND2 EGR1 CEBPB SMAD2;SMAD3 SYNE2 NRIP1 ESR2 PGR BMPR1B TSC2 CREB1 AKT1 MTOR NCOR1 TSC1 PTGER2 ZP3;POMZP3 SMPD1 PRLR GJA4 LHCGR TBP FIGLA MLH1 DAZL GDF9 FSHR WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260910%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates SLC2A1 MYC HK2 FBP1 OTUB2 LDHA USP7 USP37 PGAM1 U2AF2 KDR USP44 PGK1 OTUD7B HIF1A USP28 OTUD6B AKT1 G6PC1 MTOR FOXO1-1 VEGFA PIK3CA VHL TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260910%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex H4C6 POLR1A ASF1A POLR1B ASF1B MAPK3 POLR1D MTA1 CREBBP EP300 TLK2 UBTF H2BC21 H2AC14 H2AZ2;H2AZ1 H2AJ HDAC2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 PWWP2B CHD4 H2AC20 CHD3 H2AB2;H2AB3;H2AB1 PWWP2A KAT2A POLR1C RRN3 SRCAP TAF1D TAF1B TAF1C TAF1A EP400 MTA2 MBD3 MBD2 GATAD2B GATAD2A CDK2AP1 KAT2B H4-16 HDAC1 TBP RBBP4 TAF12 HAT1 H4C1 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260910%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses ALDH1L1 MTHFR ALDH1A1 CYP2E1 CREB1 MTR-1 CEBPB CBS;CBSL ADH5 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP3941%HOMO SAPIENS Oxidative damage response TRAF6 C1QC MAP2K4 BAD MAPK13 MAPK10 CDKN1A CDKN1B C3AR1 MAP3K9 LOC110384692;C4A;C4B_2;C4B CDKN1C CR2 TRAF1 CASP9 TRAF2 MAP3K1 TRAF3 C5 CASP3 BCL2 C1QB CDC42 BAG4 TDP2 C1S NFKBIE C1R APAF1 TNFRSF1B C5AR1 TNK2 C2 TNF CYCS-1 PCNA BAK1 GADD45A NFKB1 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK9 NRAS MAPK8 COL1A1 MAPK14 HRAS MAPK12 MAPK13 MAPK10 MAPK11 ITGA1 KRAS GRB2 SOS1 FN1 SRC AREG RAF1 PIK3CD TLN1 AKT3 PXN EGFR PTK2 ITGB1 MAP2K2;MAP2K1 MAPK1 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260910%WP2596%HOMO SAPIENS Gastric acid production CBLIF CCK GRP PGA4;PGA3;PGA5 SCT GAST PGC VIP MUC6 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260910%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex TERF2 DNMT1 CREBBP DNMT3A FLT3 GABPB1 ZFX PTEN FOXO3 ETV6 SMARCA4 DNMT3B ATM EP300 GABPA SMAD4 GZMH;GZMB-1 MCL1 BCL2L1 BCL2 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260910%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol AKR1D1 CYP7A1 EBP EPHX2 DHCR7 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 LBP ACOX2 ACOT2;ACOT1 CYP8B1 NR1I2 NR1H2 RORC CH25H IL25 ESR1 SLC27A5 CYP46A1 HSD11B1 ESR2 HSD11B2 INSIG1 SCP2 THEM5 ACOT9 HSD3B7 ACOT8 ACOT7 ACOT11 CYP39A1 ACOT12 SULT2B1 ACOT13 CYP7B1 CYP27A1 DBP AMACR BAAT GPR183 IL17D SULT2A1-4 ACOT6 IL17C IL17F SLC27A2 IL17B ACOT4 IL17A EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260910%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IFRD1 IL18 DUSP14 EIF4EBP1 NR4A3 ATF3 ANKRD1 CCN1 IL1A IL1R1 IFNG HBEGF ZEB1 MSTN EIF4E VEGFA JUND MYOG WDR1 ADAM10 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260910%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PC ALDOA AQP9 GAPDH-1 SDS PGAM1 GRHPR PGK1 GPD2 AGXT ENO1 HK1 GK GPD1 PNPLA2 TPI1 GLYCTK LIPE PCK1 KHK PFKL ALDOB FBP1 PKLR G6PC1 AKR1A1 LOC100509620;LOC112267859;AQP7 GPI MGLL MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260910%WP2001%HOMO SAPIENS miR targeted genes in adipocytes TMEM43 FADS1 CAP1 PICALM PHC2 HIPK3 IGF2R SRSF10 CSRP1 CYP1B1 ELOVL5 SRSF9 TMED10 CEBPB LPL TGFBR2 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260910%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium DLL1 PSEN1 RTN4 NGFR MECP2 NTRK1 ERBB4 NTRK3 STAT3 RET NUMB FAIM RTN4R PLXND1 NUMBL MRE11 LRP8 SEMA4A DAB1 NEURL1 APP NEUROG3 RELN MYC ID2-1 MAP2 ASCL1 PAX6 HES1 MEF2C NRG1 IL17A TCF4 CDK5 NOTCH1 GHRL MAPT NGF SOX2 ID1 BDNF CXCL12 JAG1 DISC1 KDM1A VLDLR NDEL1 MARK2 NEUROD1 PAFAH1B1 CDK5R1 MAP1B AGRN HEY1 GSK3B NTRK2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma WNT11 KLF4 DKK1 SOST WNT7B PLAU CTNNB1 TPTEP2-CSNK1E;CSNK1E FRAT2 SOX7 CSNK2A2 CCND3 SFRP4 CCND2 CSNK2B TCF7 DVL1 DVL2 FOSL1 CCND1 MYC DVL3 DKK2 DKK4 FZD10 AXIN1 CSNK2A1;CSNK2A3 SOX17 CER1 LEF1 SERPINF1 CTNNBIP1 SFRP1 SFRP2 SFRP5 CTBP2 CTBP1 TCF7L2 PORCN TCF7L1 WNT5B CSNK1A1 RYK-1 APC KREMEN1 SENP2 ROR1 ROR2 CXXC4 NKD1 NKD2 WIF1 NOTUM ELAVL1 EZH2 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 JUN FZD5 FZD7 FZD6 FZD9 FZD8 FZD1 FZD3 WNT3A WNT5A WNT7A CHD8 WNT2B WNT3 LRP6 GSK3B WNT16 NLK LRP5 MTDH SPINA BIFIDA%WIKIPATHWAYS_20260910%WP5150%HOMO SAPIENS Spina bifida MTHFD1 DNMT1 MTHFR AHCYL2 AHCY SHMT1 MAT1A MTRR DNMT3A MAT2B MTR-1 DNMT3B UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260910%WP4925%HOMO SAPIENS Unfolded protein response IL1B EIF2S1 BCL2L11 ATF6 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF4 TP53 NFE2L2 MBTPS1 ERN1 PPP1R15A XBP1 EIF2AK3 BBC3 PMAIP1 HSPA5 CASP2 BID RTCB MBTPS2 TXNIP DDIT3 BCL2 MONOAMINE GPCRS%WIKIPATHWAYS_20260910%WP58%HOMO SAPIENS Monoamine GPCRs HTR2B ADRB2 HTR2A CHRM1 HTR7 ADRA1A CHRM4 CHRM5 ADRB1 ADRA1D HTR4 ADRA1B HRH1 CHRM2 HTR6 HRH2 DRD5 ADRA2C HTR5A ADRA2B DRD1 ADRA2A DRD2 DRD3 DRD4 HTR1E HTR1F HTR1D HTR1A HTR1B CHRM3 ADRB3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260910%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis APAF1 PRF1 ENDOG DIABLO-1 CASP8 FAS CFLAR BAX HTRA2 FADD CYCS-1 FASLG CASP7 CASP9 CASP6 BAK1 BID AIFM1 CASP3 BCL2 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260910%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation ATG16L1 ATG13 ATG101 ULK1 WDR45B TNF TP53 MAP3K5 RB1 PTK2B RB1CC1 GABARAPL2 TRAF2 PTK2 GABARAP DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260910%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MYC LONP1 TSC2 SLC7A7 CLPP TRAP1 GDF15 MARS1 ATF4 PHB AKT1 OMA1 MTOR PHB2 TSC1 HSPD1 LARS1 SESN2 LONP2 IRS1 EIF2A FOXO1-1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260910%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR3 GPR6 MC5R F2RL1 F2RL3 OR1C1 GPR68 GPR65 GPR63 CCRL2 GHSR GPER1 OR2D2 NPY1R OR2T1 APLNR OR5V1-2 OR2C1 SUCNR1 OR5I1 C3AR1 GPR87 C5AR2 GPR85 MCHR1 OR1Q1 HCAR1 OR2B3 OR2F1-2 OR2J1;OR2J2;OR2J3-2 NMUR2 NMUR1 OR14J1 MLNR OR7C1;OR7C2-9 PRLHR NPY5R OR1F1 OR2H2 AVPR2 OPRM1 SSTR1 SSTR3 SSTR4 SSTR5 OR10A4 HTR1E OR10A5 HTR1F OR2A7;LOC107987545;OR2A4 HTR1D OPN1MW3;OPN1MW2;OPN1MW;OPN1LW HTR1A CNR2 HTR1B OR8B8 OR2W1 OR12D3 OR1D2 OR10J1-2 OPN1SW CXCR5 ACKR4 OR11A1 ACKR2 GPR37 FPR2 LTB4R CMKLR1 AGTR1 AGTR2 GPR83 LPAR4 LPAR5 LPAR6 FFAR2 MAS1 CHRM2 F2R ADRB2 CXCR4 ADRA1B P2RY6 P2RY4 P2RY2 ADORA3 P2RY1 P2RY12 P2RY13 P2RY10 P2RY11 P2RY14 BDKRB1 GPR32 CHRM3 ADORA2B PTGFR PTGDR2 CCR9 TBXA2R PTGDR HTR7 PTGIR RHO CCR8 CCR6 SSTR2 CX3CR1 MC3R LHCGR FSHR HTR2B HTR2A CHRM1 NPY2R ADORA1 ADRA1A MTNR1A MTNR1B HRH3 GPR75 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 ADORA2A OPRL1 CYSLTR2 HCRTR2 HCRTR1 CCR3 NPFFR1 CCR2 FFAR3;GPR42 CHRM4 CHRM5 ADRB1 ADRA1D HTR4 OPRK1 HRH1 HTR6 HRH2 DRD5 ADRA2C HTR5A ADRA2B ADRA2A PTGER4 PTGER2 GPR161 NPFFR2 OXTR RRH GRPR GPR174 GPR173 EDNRA EDNRB GPR171 GPR37L1 TRHR PTGER1 OR7A10;OR7A17-11 PTGER3 OR2AG1;OR2AG2 FPR1 OR1I1 MC2R GALR3 GALR2 GALR1 CYSLTR1 NPBWR1 NPBWR2 OR6B1 CCR10 NTSR1 NTSR2 CCR1 GPR17 XCR1 GPR15 GPR12 NMBR MC1R HCAR2;HCAR3 OR6A2 GPR18 ACKR3-2 BDKRB2 GPR19 GPR27 CNR1 GPR25 GPR21 GPR22 GPR20 NPY4R2;NPY4R OR10H1;OR10H5;OR10H2 BRS3 MC4R CCKAR OR2B6;OR2B2-1 CCR7 FFAR1 CCR5 CCR4 GPR39 AVPR1B GPR34 GPR35 OR2H1-1 OR1A1-1 AVPR1A OR2S2-1 CCKBR F2RL2 OR1E1;OR1E2 OR3A2 OR3A1 OPRD1 GPR45 PTAFR CXCR1 CXCR3 CXCR2 ADRB3 CHML GPR52 GPR1 OR8D2-1 GPR4 GPR50 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260910%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMP2 RUNX2 SMURF1 SMAD1 BMPR1B SMAD6 SMAD4 BMPR1A TOB2 TOB1 BMPR2 NOG NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260910%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death UVRAG AMBRA1 INSR ATG16L1 ATG14 TSC2 ULK2 ULK1 MAP1LC3A TSC1 SH3GLB1 ATG3 ATG10 INS;INS-IGF2 ATG12-1 ATG9B CHAF1A VMP1 BECN1 BCL2 ATG4A ATG7 ATG5 PURINE METABOLISM%WIKIPATHWAYS_20260910%WP4792%HOMO SAPIENS Purine metabolism DGUOK ITPA ADA PRPS1 ATIC ADSL IMPDH1 HPRT1 ADSS2 XDH PNP-1 AMPD1 APRT GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260910%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GGCT GGT1 DPEP1 GSS OPLAH GCLC NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260910%WP5399%HOMO SAPIENS NPHP1 deletion syndrome PTK2B FLNB FLNC MAPK3 NPHP1 FLNA RPGRIP1L BCAR1 MAPK1 INVS PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies JAK2 IL12RB1 IL1B CCR6 IL17RC IL23A STAT3 TNF IL12B CCL20 TYK2 IL22 IL23R CXCL2;CXCL3;CXCL1-1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IL17F IL17A CXCL8 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer PDGFD PDCD1 PDGFC IL6 LGALS3 LGALS1 IL13 VEGFB IL10 VEGFD PDGFA IL4 CD40LG PDGFB SHH VEGFA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD28 NT5E IDO1 PVR VSIR B2M TNFRSF4 HAVCR2 FAS ENTPD1 PDCD1LG2 CD226 VTCN1 VDR ICOS TIGIT CCL17 CD276 CCL22 TNFRSF9 TNFSF4 FAP TNFSF9 CXCR4 CXCL12 CD40 LGALS9C;LGALS9;LGALS9B CD86 CD274 CD80 FASLG VEGFC CTLA4 TGFB2 TGFB1 TGFB3 ARG1 PGF RETT SYNDROME%WIKIPATHWAYS_20260910%WP4312%HOMO SAPIENS Rett syndrome TCF4 STXBP1 GABRA3 NCOR2 MECP2 CHD4 SYNGAP1 TAF1B KDM5B TRRAP FOXG1 SATB2 CRK GPS2 RHOBTB2 CECR2 HIVEP2 SCN1A SRRM3 SYNE2 EIF2B2 CDKL5 KCNJ10 SMARCA1 SMC1A SMARCA2 TBL1XR1 IMPDH2 XAB2 HAP1 SCN2A SCN8A SHANK3 SMARCA4 ACTL6B HDAC5 HTT HDAC8 GRIN2A GNAO1 NCOR1 HDAC1 BRAF GRIN2B MEF2C GABRD GABBR2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260910%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DICER1 AGO2 ERI1 XPO5 DROSHA DGCR8 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260910%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling TLE1 DICER1 RUNX2 HMGA2 CDK6 TARBP2 AGO2 ICMT LMNA ZMPSTE24 CTNNB1 SREBF1 FNTA WNT10B CEBPA ADIPOQ CEBPB TCF7 SLC2A4 CCND1 SPP1 EMD CEBPD TOR1AIP1 AXIN1 LEF1 GSK3B HES1 HES5 TCF7L2 PPARG TCF7L1 CSNK1A1 APC SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260910%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder CACNA1C EIF4EBP1 MAPK3 PRKAA1 RHEB RPS6KB1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 HOMER1 PRKAB2 PRKAB1 PTEN GRIN2A GRIN2C GRIN2B GRIN2D CAMK2B NRAS PIK3R3 GRM1 HRAS UBE3A SYNGAP1 NF1 ARC KRAS BDNF DLG4 GRIN1 RPTOR TSC2 SHANK3 CAMK4 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR GRIN3B GRIN3A TSC1 GSK3B NTRK2 PIK3R2 PIK3CA PIK3R1 MAPK1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260910%WP4823%HOMO SAPIENS Genes controlling nephrogenesis EYA1 ILK NCK2 NOTCH2 NPHS1 GDNF NPHS2 WT1 LHX1 CD36 FOXC2 FOXC1 RET ITGA3 CTNNB1 WNT4 ITGA8 CXCR4 CXCL12 NCK1 MAFB CD2AP SIX1 TCF21 KDR LMX1B FGFR2 PDGFB LAMB2 PDGFRB EMX2 FOXD1 SHH HNF1B ROBO2 GLI3 HOXD11 HOXA11 PAX2 SLIT2 KIRREL1 FGF8 MAGI2 ETV4 VEGFA ITGB1 IL7 SIGNALING%WIKIPATHWAYS_20260910%WP205%HOMO SAPIENS IL7 signaling IL7R MAPK3 JAK1 STAT1 BAD FYN STAT3 AKT1 JAK3 IL2RG IL7 PTK2B GSK3B PIK3R2 PIK3R1 STAT5A STAT5B MAP2K2;MAP2K1 MAPK1 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260910%WP3298%HOMO SAPIENS Melatonin metabolism and effects PRKCA TRAF6 PER2 PER1 CAMK2A CYP1A2 SIRT1 TPTEP2-CSNK1E;CSNK1E EDN1 CSNK1D CYP1A1 CLOCK FOXO1-1 ACHE MTNR1A APOE MTNR1B ADRB1 AANAT CYP2D6;LOC107987479;LOC107987478-1 MAP2 CYP2C9;CYP2C19 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 IRAK1 MAOA GSK3B ASMT ECE1 ARNTL NFKB1 CRY2 CALM1 CRY1 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260910%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 PNPT1 XRN1 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260910%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation ITGB3 ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 LATS2 CTNNB1 ITGA1 ITGAD ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PRKACB-1 PRKAR2B CCND1 PRKAR2A PAK1 MYC PAK3 PAK2 PRKAR1B PAK4 KDR PRKAR1A PDGFRB RBX1 KIT PPP1CA WWTR1 PLCB4 PPP1CB PPP1CC TEAD2 CDH1 CTNNA1 DDB1 FLT3 CDH9 AMOT EPHA2 CDH7 DCAF1 CXCL10 CDH5 CUL4A CDH4 CDH3 CDH20 CDH22 CDH24 NGFR PPP1R12A CDH10 CDH11 CDH12 NTRK1 CDH13 CDH15 CDH17 CCN2 CDH18 VGLL4 CDH19 PPP1R14A CDH6 CDH2 IGF1R CDH16 INSR PDGFRA FLT4 CSF1R EGFR NRAS STK3 SAV1 LIN28B CD44 YAP1-1 HRAS TEAD1 TEAD3 TEAD4 MST1 LATS1 KRAS NF2 BUB1B-PAK6;PAK6 AJUBA MET ITGA2B PAK5 FGFR4 PRKACA-1 FGFR3 FGFR2 FGFR1 TEK NTRK2 CDH8 PTK2 ITGA10 FLT1 ITGA11 FOXM1 ITGB1 ITGAM ITGB5 ITGB4 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260910%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation TRAF6 CBLB CD3G CD3E IKBKB PDPK1 ELOB IKBKG CHUK VAV1 PCBP2 CD247 ITK CDKN1B SMARCB1 DGKA CD3D TMEM222 GRAP2 RELA GRB2 ARIH2 UBASH3A RHOH RASA2 AGO3;AGO1 NFKBIA CARD11 BCL10 PTPN6 MALT1 ZFP36L1 RPRD1B SH2D1A FIBP CD5 LCP2 LAT GNA13 MAP3K8 CD28 MAP3K14 PRKCQ PLCG1 MAP4K1 CUL5 RNF7 TNFAIP3 LCK CD8A MEF2D DGKZ NDUFB10 AKT1 SOCS1 REL PIK3R2 PIK3R1 ZAP70 SH2B3 NFKB1 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260910%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260910%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 MYD88 TRAF6 IRF3 IKBKB IKBKG CHUK TICAM1 RELA TRAF3 TICAM2 TIRAP TLR1 TLR9 TLR5 TLR8 TLR6 TLR2 TLR7 TLR4 TLR3 IRAK1 REL RELB TBK1 IRF7 TOLLIP IRAK4 IKBKE NFKB1 MAPK1 NFKB2 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260910%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G5 PLA2G6 ALOX5 PLA2G2D PLA2G1B PLA2G12A PLA2G4F HRAS PLA2G12B PLA2G4D PLA2G4A PLA2G4E TP53 PLA2G3 PLA2G7 CDKN1A SLCO2A1 PLA2G10;LOC100652777 PTGS2-2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260910%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin PRKCA ADRB2 NPR1 ANKRD1 MYPN CAMK2A GUCY1B1 ADRB1 PRKACB-1 RAF1 PRKACA-1 PRKAR1A PRKG2 MDM2-2 TRIM63 FHL1 GUCD1 CSRP3 PLCZ1 ANKRD2 ANKRD23 TTN-1 NBR1 TCAP FHL2 CRYAB MAP2K2;MAP2K1 TRIM55 MAPK1 SRF NUP62 HUNGER AND SATIETY%WIKIPATHWAYS_20260910%WP5445%HOMO SAPIENS Hunger and satiety PYY GCG POMC MC4R AGRP NPY GHRL LEP ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260910%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma MYL3 ADRB2 ADCY3 ADCY8 PLCB3 PLCB4 GNAS-1 PLCB1 PLCB2 NR3C1 ADCY4 ADCY2 PRKACB-1 ADCY7 ADCY6 PRKAR2A ADCY5 PRKACA-1 PRKAR1B PRKAR1A CREB1 ADCY9 ADCY1 MYL4 MYL2 MYL1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260910%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO3 FMO4 FMO5 FMO1 FMO2 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260910%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways MAT2A SARDH MTR-1 GPX6 CBS;CBSL MAT1A BCAT1 SHMT2 BCAT2 PLD1 MTHFR SOD3 SOD1 CTH GPX5 BHMT2 BAAT ALDH7A1 PCYT1A DNM1 DMGDH AHCYL1 CSAD AHCYL2 SLC25A48 DNMT3L AHCY GAD1 PCYT1B SHMT1 GPX7 PHGDH DNMT3A MTHFD2L MAT2B GAD2 TYMS CHKA AGXT2 GNMT PSPH MTHFD1L ETNK2 DNMT3B CEPT1 CDO1 AMT DHFR2;DHFR CHKB PCYT2 BHMT MTHFD1 MTHFD2 CHDH GPX1 GPX4 PEMT GSS PSAT1 CHPT1 GSR GCLC GCLM ETNK1 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260910%WP2005%HOMO SAPIENS miR targeted genes in muscle cell NRP1 PKM GJA1 RHEB CACNA2D1 ESR1 CCND1 ERBB2 DSG2 FGF2 DHX15 PTBP2 UBE2J1 KIT SLC38A1 NT5E PPP3CA CPNE8 VEZT ACAA2 SRPRB-1 BACE1 ZEB1 ARF4-1 PWP1 SRSF10 CDIPT CIAO2A POGLUT3 RARS1 TPM3 FNDC3B G6PD FNDC3A EIF4E DHX40 RAB34 RAI14 SRSF9 TMED10 CBFB MRPL20 BCL2 COMMD9 ANPEP SLC38A2 ATP6V1C1 SLC4A10 TBCA MOV10 NCL-1 WNT5A CHMP2A ANP32B PICALM TRAM1 ADAR MAGT1 MRC2 SPTLC1 CYP1B1 SH3BGRL3 TMED7 TMED2-1 SEC24A ATRX CAPG PPIF CSDE1 PXDN PTMA MTPN SEC23A DNAJB1 POLR2C PPP1R7 SH3BP4 RTN4 PDLIM7 MPZL1 SLC12A2 COL1A1 GALNT7 COL1A2 TXNRD1 ERBB3 GALNT1 AP3D1 GSTM4 ARCN1 SPCS3 FMNL2 ATP6V0E2;ATP6V0E1 NEDD4 PDCD4 SLC7A11 LAMTOR5 ATP2A2 BET1 AGO3;AGO1 COL3A1 SYNE2 SYNE1 TMEM43 NCOA3 GNA13 EGFR TPM1 CDKAL1 HES1 E2F3 PRKCI SLC12A4 NOTCH2 NOTCH1 TYMS LAMC2 CYP51A1 LAMC1 BACH1 CHORDC1 RAVER2 CDK5RAP1 ANKFY1 SEC62 MTHFD2 VPS39 CDK5RAP3 TMEM41B-1 MBNL1 SCAMP1 CXCL12 CARHSP1 METTL7A-1 PDE3A WDR82 KCNQ1 FAR1 TMEM87A HACD3 GRPEL2 PANX1 ATP6V0A1 SNX6 RAB27B NCEH1 SFXN1 PTPA GFM1 ASH2L PTPRJ PTPRF COIL PISD HYAL3 TMED3 GNL3L-1 GNPNAT1 CTSC MRPS24 RHOG AP3B1 CPOX GAK SLC7A6 CDCP1 VSNL1 FRG1 BRPF3-1 SSNA1 AMIGO2 FSTL1 NAPG SLC38A5 PGRMC1 SHOC2 CA12 ITGB4 SPRYD4 TTC9C WDR11 TPPP3 SNX15 LRRC8A NUCB1 MAPK7 LAMTOR3 TUSC2 LTN1 ARID4B SDCBP LCLAT1 PODXL ABHD10 MAPK14 KPNA3 MAPK12 TPM4 TPM2 ATG9A CTNNB1 STX7 ITGA2 RB1 PKN2 UBE4A CSNK1D CDKN1A RAB30 CDKN1B DMTF1 WDFY1 MATR3 CLOCK GEMIN7 ERG SLC1A4 UAP1 CORO1C SLC9A3R2 CAMTA1 RAB6A ANAPC1 CD164 CNOT9 SLC25A1 DOCK5 CALCOCO2 SNAP23 DOCK7 TNFAIP2 CHD1 TMEM109 SLC25A13 PLK1 ACP2 SNAP29 SCYL1 HSDL1 ARHGDIA ARID1A RCN2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A RFT1 RBMS1 YWHAQ LUZP1 NUFIP2 NXN UHRF1 ACVR1B CAND1 TP53INP1 E2F1 IGF2BP1 ZNF622 PDLIM5 SLC25A24 MYO10 EHMT2 TM6SF1 SLC4A7 EHMT1 SLC25A32 SRF NAA15 CDK6 CCNG1 DNMT3A EZH2 IRS1 MYLIP ADIPOR2 RAD23B RDH10 TDG GFPT1 POLD2 USP1 PPIB TGFBR2 POLE4 IFRD1 CCN1 ABCG2 MTRR GPD2 HIPK3 CUL4B IGF2R CSRP1 ELMOD2 TXN2 CEBPB C1QBP HMOX1 SYPL1 SPARC HDAC4 POLA2 CSF1 NELFCD ATAD3A;ATAD3B MCL1 HSD17B12 GRIA2 PGM1 KRAS P4HA2 NF2 PSAT1 CLDN1 GPAM AXL MET PAFAH1B2 STRN FADS2 MYO1E PHLDB2 THBS1 NFIA IPO4 LRP1 LMNB2 LPL NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260910%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling LRRC8A ADCY8 FOS SLC1A4 DLD PDHA1 CNTF CREB1 FGF2 TNF IL10RB GRIN2A ADCY1 SLC38A1 GRIN2C LIF GRIN2B GRIN2D IGF1 CALM1 GOT1-1 GLUL NSMF SLC1A6 IL1B SLC38A3 GLS2 GRIA3 PPP1CA GRIA4 SLC1A3 TRPM4 DAO SLC6A9 GRM5 GRIK5 GRIK3 GRIK4 GRIK1 PLCB3 GRIK2 SLC7A10 PLCB4 PPP1CB GRM2 SLC17A6 PPP1CC GRM4 SLC17A7 GRM7 TNFRSF1A GRM8 PLCB1 DLAT PLCB2 IRS1 TRAF5 LTA BDNF SRR LRRC8C LRRC8D LRRC8B LRRC8E TGFBR1-1 BCL2 DISC1 CAMKK1 SLC38A2 IL13RA1 GRIN1 NOS1 TNFRSF1B IL1R1 IFNGR2 AKT1 GRIN3B GRIN3A STAT6 TGFB2 IL4R TGFB1 TGFB3 SOCS3 NFKB1 IL10RA NFKB2 MAPK1 TGFBR2 IL6R MAPK3 JAK1 STAT1 STAT3 IL12B IL6 IL13 SLC1A2 IL6ST SHMT2 CAMKK2 IL10 INSR GFAP CFL1 IL4 IL1A IFNG IL12A SMAD7 SLC1A1 IL1R2 PRKCG PRKCB PRKCA SLC2A1 ADCY3 CAMK2B GRIA1 GLS SHMT1 CAMK2D PHGDH CAMK2A GRIA2 PSPH GRM1 CAMK2G NGF ARC SMAD4 PSAT1 SMAD2;SMAD3 IFNGR1 PRKACA-1 CAMK4 TGFBR3 SLC38A5 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260910%WP4298%HOMO SAPIENS Acute viral myocarditis ITGB2 ILK ITGAL MAPK3 JAK1 RAC3 STAT1 ABL2 STAT3 IL12B CCR3 EDN1 IL6 SGCD SGCA SGCB CASP9 DAG1 SGCG MMP9 SOS1 BCL2L1 CASP3 IL10 SRC CCND1 IL2 IFNG CD40LG ENDOG CREB1 IL12A AIF1 TLR4 TNF TLR3 CD55 ACTB-1 CYCS-1 CD4 PYCARD ABL1 CASP7 CASP1 CASP6 CASP2 BID RASA1 MYH6 DMD CASP8 BAX PARP1 EIF4G1 TICAM1 CXCR4 LAMA2 NOD2 CAAP1 HLA-DMA PTCRA BCL2 DFFB DFFA CXADR KRT8 CHRAC1 BNIP2 PABPC1;PABPC3 EIF4G2 NOS1 CCR5 TLR5 FYN AKT1 CD80 SOCS1 GSK3B CAV1 PIK3R1 TGFB1 MAPK1 NFKB2 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260910%WP3601%HOMO SAPIENS Lipid particles composition APOC3 APOC2 APOA1 CETP APOA2 APOE APOB LPL LDLR LCAT ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260910%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 TP53 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260910%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260910%WP2857%HOMO SAPIENS Mesodermal commitment pathway DLL1 GATA6 FOXC2 VAV3 FOXC1 PITX2 HPRT1 ZFHX4 SESN1 CCND1 HNF4A PRKAR1A AXIN2 SOX17 PAX6 TOX3 CTBP2 SRF BMP4 TCF4 IQCJ-SCHIP1;SCHIP1 ELK4 PBX1 CRTC1 FOXA1 SOX2 TEAD2 ACACA PPP2CB;PPP2CA FOXA2 SOX21 TRIM28 WNT3A CEP250 RARG DIP2A RPL38 HES7 ACVR1 WNT3 EOMES WDHD1 ZNF281 PIAS1 EMSY ADAM19 TOX TWSG1 WDFY2 BCORL1 BHLHE40 MACF1 MBTD1 ACVR2A EPB41L5 RARB UBR5 ATP8B2 PBX3 GDF3 TRERF1 NLK CCDC88A NABP2 TRIM71 SETD2 NCAPG2 PHF6 JAK2 CSRP2 ZIC2 ZIC3 TRIM5 KLF4 DKK1 JARID2 KDM6A SLC2A12 MSGN1 TET1 PARP8 ARL4A DDAH1 CUL4B PLCH1 AEBP2 MTF2 HAND1 AHDC1 C9orf72 WDCP AMH ASCC3 SNAI1 ZNF462 ELP4 GRHL2 ACVR2B TBX3 MEIS1 RGS10 C1QBP TBX1 ARID5B BMP7 EXT1 EXT2 GATA3 NFE2L2 HTT AXIN1 KLF5 LEF1 FGF8 TCF7L1 POU5F1;POU5F1B HMGA2 CHRD NANOG;NANOGP8 YAP1-1 TEAD1 DNMT3B MIXL1 NODAL LATS1 SMAD1 SMAD4 TBX6 FZD5 FZD4 CCDC6 SMAD2;SMAD3 FZD8 PRKACA-1 BMPR1A FGFR1 LEFTY2;LEFTY1 BMPR2 NOG FOXH1 INHBA SMAD6 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP304%HOMO SAPIENS Kit receptor signaling JAK2 TEC MAPK3 STAT1 BAD MAPK14 STAT3 PTPN11 EP300 VAV1 GAB2 RPS6KB1 CBL GRB2 INPP5D SOS1 CRK LYN GRB10 STAT5A STAT5B MATK BTK SHC1-1 MITF DOK1 PTPN6 SRC SOCS6 SH2B2 KITLG KIT PRKCB PRKCA GRB7 MAPK8 PLCG1 HRAS RPS6KA3 RPS6KA1 MAPT CRKL RAF1 FYN FOXO3 AKT1 SOCS1 RPS6 PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260910%WP5601%HOMO SAPIENS Caffeine in blood vessels ADCY3 RYR3 RYR2 ADCY8 PPP1R12A PPP1CB GUCY1A2 ADRA1A GUCY1A1 PDE3A ADCY4 ADCY2 ADRA1D ADCY7 ADCY6 PDE3B ADRA1B CALM3;CALM1 MYLK ADCY5 PDE4B PDE4A PDE4D-1 PPP1R12C ADORA3 NOS3 ADCY9 ADORA2A ADORA2B ADCY1 CALM1 CALM2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260910%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MYD88 TRAF6 MAP3K7 IRF3 JAK1 MAPK8 STAT1 MAVS MAPK14 IKBKB RIPK1 TYK2 IKBKG CHUK TICAM1 FOS JUN TRAF3 NFKBIA IFNAR2 STAT2 OAS3 TLR7 OAS1 IRF9 IFNAR1 IFIH1 EIF2AK2 TBK1 IKBKE NFKB1 DDX58 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260910%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC6A6 SLC15A2 CARNS1 SLC15A4 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260910%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STK11 PRKAA1 CTDSP1 STRADB PTBP1 SIX4 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260910%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFAB1 NDUFS5-1 NDUFA12 NDUFB11 NDUFA10 NDUFA13 NDUFC1 NDUFS6 NDUFS4 NDUFB3 NDUFS3 NDUFS2 NDUFS1 NDUFB9 ECSIT NDUFB8 NDUFB7 DMAC2 NDUFB10 FOXRED1 NDUFB6 TMEM186 NDUFB5 TMEM70 NDUFB4 NUBPL ACAD9 NDUFB2 NDUFAF6 NDUFAF7 NDUFB1 NDUFAF4 NDUFAF2 NDUFAF3 TMEM126B NDUFAF1 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFV1 TIMMDC1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260910%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins EPB41L2 NCDN EFNA5 NEO1 MAPK9 NTNG1 CADM3 APLP2 CADM1 CASK ANK3 TERF2IP MAPK4 SNW1 ATP2B1 PRKCZ RAP1GAP GRIK2 PLCB4 KCNQ2 CAMK2G KCNJ6 CDH2 STX2 DAB1 GRIN1 CLASP1 AGRN KCNMA1 CAV2 GPHN GRIN2B EPB41 GABRG3;GABRG2 CLSTN1 STXBP2 CSN3 EPB41L1 CHL1 GABBR2 GPCRS OTHER%WIKIPATHWAYS_20260910%WP117%HOMO SAPIENS GPCRs other PTGFR HTR7 UTS2R CCR2 C5AR2 OR2F1-2 ADRA1D CHRM2 OR1F1 SSTR2 F2R OR10A5 OR2A7;LOC107987545;OR2A4 HTR1F GRPR EDNRA PROKR2 FSHR ADRB2 HTR2A SMO OR2M4 GPR61 GPR62 CELSR1 GRM1 NTSR1 RXFP1 OR7E24-1 CELSR3 GPR17 RXFP3 GPR176 GPR132 ADGRE3 S1PR1 GNRHR GPR135 ADGRV1 OR8G1;OR8G5 GPR18 TAAR5 OR1J2 TAAR2 CNR1 OR1N1 GPR162 LTB4R2 ADGRF5 VN1R1 OR6C3 GPR88 GPR84 OR2B6;OR2B2-1 MCHR2 GHRHR ADGRG1 CCR5 HRH4 ADORA3 OR6C2;OR6C68 ALG6 OR5AC2-2 GPR55 DRD3 ADGRD1 DRD4 P2RY13 GPR143 OR2H1-1 ACKR1 P2RY11 OR2A5 ADORA2A LGR6 ADGRL2 CCKBR ADGRL3 CHRM3 OR1E1;OR1E2 OR3A1 CELSR2 CXCR1 GPR183 CXCR3 CXCR2 GPR83 FOXP3 IN COVID 19%WIKIPATHWAYS_20260910%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL6R IL2RA IL2 IL2RB IL7R FOXP3 STAT3 CD86 CD80 IL2RG IL6 IL6ST CD28 STAT5A STAT5B SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260910%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260910%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PPP3CA PPP3CB CAMK2D CTF1 MAPK8 MAPK14 STAT3 GATA4 MAPK11 AGT MYEF2 RHOA EDN1 LIFR FOS MAP2K3 JUN IL6ST NFATC4 CALM1 PRKCB MAPK1 PRKCE RAC1 NRF2 PATHWAY%WIKIPATHWAYS_20260910%WP2884%HOMO SAPIENS NRF2 pathway SLC5A6 ALDH3A1 SLC5A9 CES3 CES2 EPHA3 SLC5A3 SLC5A5 CES5A PTGR1-1 SLC5A4 RXRA PRDX6 SLC6A5 SLC2A9 SLC6A7 SLC6A19 SLC6A8 MAFF SLC2A5 PPARD SLC2A6 SLC2A7 SLC2A8 SLC2A11 SLC2A10 ABCC5 SLC2A13 SLC39A11 SLC39A10 SLC39A13 SLC39A12 EGR1 SLC39A14 SLC5A11 SLC5A12 SLC5A10 CBR3 TXNRD3 PDGFB FTL-1 SLC6A9 ABCC3 ABCC4 G6PD ABCC2 BLVRB GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GCLC ME1 GSTA3;GSTA5;GSTA1;GSTA2 SLC6A1 GCLM SLC6A2 GGT1 SLC6A3 SLC6A4 SLC5A7 TGFB2 TGFB1 MGST3 EPHA2 MGST2 TGFBR2 DNAJB1 AGER SRXN1 CES1 SERPINA1 SLC2A12 HBEGF TXNRD1 GSTM4 GSTM3 PRDX1 KEAP1 HGF MAFG SLC7A11 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TGFA SLC6A18 SOD3 SLC5A8 HMOX1 SLC6A6 NFE2L2 UGT1A1;UGT1A6 SLC39A2 SLC39A1 SLC39A4 SLC39A3 SLC5A2 SLC6A20 NRG1 SQSTM1 SLC2A1 GSTP1 FGF13 SLC6A11 HSP90AB1 CYP2A13;CYP2A6;CYP2A7-1 SLC2A2 CBR1-1 HSP90AA1 GSTA4 SLC5A1-1 SLC2A4 NQO1 HSPA1A;HSPA1B SLC39A9 FTH1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC6A13 TXN PGD SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260910%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD CHUK IKBKG THBD AGER RELA HMGB1-1 NFKBIA NFKB1 IKBKB CCL18 SIGNALING%WIKIPATHWAYS_20260910%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 AK4-1 CDH2 PTK2B CCR8 MMP2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260910%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOB UBB;UBC RUNX1 RBX1 CUL5 CBFB ELOC-1 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NEU2 FUCA1 ST3GAL4 NAGA B4GALT1 B3GNT5 FUT2 FUT1 FUT6;FUT5;FUT3 B4GALT4 B4GALT3 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX15 ALOX5 EPHX2 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260910%WP4249%HOMO SAPIENS Hedgehog signaling SMO CSNK1G1 SPOP DHH TPTEP2-CSNK1E;CSNK1E CUL3 ARRB1 CSNK1D ARRB2 SMURF1 GLI1 LRP2 CCND2 PTCH1 BCL2 PRKACB-1 CCND1 PRKACA-1 HHIP GRK3 GRK2 KIF3A BOC EVC2 CSNK1G3 PTCH2 IHH GLI2 FBXL17 SHH KIF7 EVC SPOPL GLI3 GAS1 SMURF2 CSNK1G2 GPR161 CDON CSNK1A1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260910%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC2A1 SLC7A11 SLC1A5 GLS PSAT1 PHGDH PSPH DNA REPLICATION%WIKIPATHWAYS_20260910%WP466%HOMO SAPIENS DNA replication UBB;UBC MCM2 POLE2 RPA3 CDK2 POLA1 UBA52 MCM7 POLE RFC5 RFC3 RFC4 MCM3 RFC2 MCM4 MCM5 MCM6 PRIM2 PRIM1 ORC5 RFC1 ORC4 CDC45 ORC6 ORC1 ORC3 CDC7 ORC2 CDC6 POLD3 POLD4 POLA2 POLD1 POLD2 PCNA GMNN MCM10 CDT1 DBF4 RPA1 RPA2 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260910%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness ITGB3 RYR3 PRKCQ MAPK3 CREB1 ITGAV PLCG1 TNNC1 MFAP5 JUN PTK2 MAPK1 ITPR3 ESTROGEN METABOLISM%WIKIPATHWAYS_20260910%WP697%HOMO SAPIENS Estrogen metabolism COMT NQO1 STS CYP1A2 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ARSD-1 ARSL GSTM1;GSTM2-1 GSTA3;GSTA1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 VAMP2 CREB1 YAP1-1 BCL2L11 CDKN1A POMC CDKN1B FOS IL6 CDKN1C CRP ADIPOQ VEGFA INS;INS-IGF2 PPARG ZINC HOMEOSTASIS%WIKIPATHWAYS_20260910%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A2 SLC30A5 SLC30A4 SLC30A1 MT3 MTF1 SLC30A9-1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC39A2 SLC39A1 SLC39A4 SLC39A9 SLC39A3 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC30A10 SLC30A7 SLC30A6 SLC30A8 SLC30A3 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260910%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2C ERCC3 TAF7 TAF6 TAF5 ELK1 NELFB NELFA NELFCD MED9 NELFE CCNC-1 POLR2A MED19 MED16 MED18 MED17 MED12 MED11 MED14 MED13 MED10 MED1 MED8 MED4 GTF2F1 MED27 MED26 MED6 MED29 MED7 MED23 MED22 MED25 MED24 THRA MED21 MED20 GTF2A1 MED28-1 CTDP1 MED15 MED30 POLR2D POLR2L POLR2M TAF10 TAF11 TAF8 MED31-1 TAF4 TAF3 TAF2 TAF1 GTF2B TAF9 GTF2E2 POLR2B POLR2E POLR2F CDK8 POLR2G POLR2H POLR2I TBP TAF12 TAF13 POLR2J;POLR2J2;POLR2J3 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260910%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 NBN MRE11 DDX1 DROSHA ATM DGCR8 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260910%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production IDO1 NMRK1 NMNAT3 NADSYN1 NMNAT2 NMRK2 NAPRT NMNAT1 NAMPT QPRT AADAT HAAO KMO TDO2 KYNU AFMID INSULIN SIGNALING%WIKIPATHWAYS_20260910%WP481%HOMO SAPIENS Insulin signaling MAPK9 MAPK7 PRKAA1 MAPK6 MAPK4 MAP4K5 MAPK14 MAPK12 ELK1 MAPK13 IKBKB PDPK1 MAPK10 MAPK11 FOS RHEB RAPGEF1 CBL PRKAA2 CRK EGR1 LIPE SNAP23 SORBS1 SNAP25 KIF3A RPS6KA5 XBP1 MAP3K8 MAP3K3 GSK3A MAP3K14 SRF GRB14-1 VAMP2 STXBP1 MAPK8 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K9 MAP2K7 IRS1 EIF4E MAP3K4 IRS2 MAP2K6 MAP2K3 FOXO1-1 JUN MAP3K1 MAP3K10 RAF1 MAP3K11 TSC2 IRS4 KIF5B AKT2 INPPL1 AKT1 CBLC MAP3K5 MTOR RPS6KA4 ENPP1 MAP3K6 GYG1 SOCS1 INPP4A STXBP3 GSK3B STXBP4 RRAD PIK3R2 PPP1R3A PIK3R1 EHD1 ARHGAP33 SOCS3 EHD2 MAP3K13 MAP2K2;MAP2K1 ARF1 MAPK1 FLOT1 RAC1 TRIB3 FLOT2 EIF4EBP1 MINK1 CBLB MAP3K7 RHOJ PTPN1 RHOQ ARF6 MAPK3 CYTH3 STX4 MAP2K4 SGK3;C8orf44-SGK3 MAP3K2 REG1B;REG1A CAP1 MYO1C PRKCD PFKM GAB1 GYS2 PTPN11 MAP3K12 GYS1 SGK1-1 IGF1R RPS6KB1 GRB2 SOS1 GRB10 SHC1-1 SHC2 SH2B2 INSR PTEN SOS2 PRKCI PRKCH STXBP2 PRKCB PRKCA SLC2A1 RPS6KB2 PRKCQ PIK3R4 PIK3R3 PRKCZ HRAS MAP4K3 MAP4K4 MAP4K1 MAP4K2 SLC2A4 PFKL RPS6KA6 PTPRF FOXO3 PIK3CD PIK3C2G SHC3 PIK3CB PIK3C2A PIK3CG TSC1 MAP2K5 TBC1D4 PIK3CA RAB4A PIK3C3 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260910%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACE2 ELOVL2 ELOVL5 ACOT2;ACOT1 FADS2 FADS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260910%WP5293%HOMO SAPIENS Acute myeloid leukemia EIF4EBP1 MAPK3 CSF2 BAD MPO SPI1 STAT3 DUSP6 IKBKB BCL2A1 PPARD CEBPE FCGR1A IKBKG CHUK RUNX1T1 JUP ZBTB16 CEBPA RPS6KB1 RELA GRB2 GLI1 CCNA1 SOS1 STAT5A STAT5B TCF7 CCND1 MYC RUNX1 CSF1R IL3 CCNA2-1 SOS2 LEF1 PIM2 KIT TCF7L2 TCF7L1 PML RPS6KB2 PER2 NRAS PIK3R3 CD14 HRAS KRAS RAF1 ARAF FLT3 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR RARA PIK3R2 BRAF PIK3CA PIK3R1 PIM1 ITGAM MAP2K2;MAP2K1 NFKB1 MAPK1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260910%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2J2-1 GSTP1 COX8A COX5A CYP2C9;CYP2C19 EPHX2 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260910%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260910%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260910%WP5146%HOMO SAPIENS Lung pathology of COVID 19 IL18 CXCL10 IRF3 IL1B CSF2 MAVS TLR8 STING1 TLR7 TNF TLR3 CCL13;CCL2 CXCL9 CGAS IL6 IFIH1 TBK1 NFKB1 CXCL11 DDX58 ANGIOGENESIS%WIKIPATHWAYS_20260910%WP1539%HOMO SAPIENS Angiogenesis KDR FGFR2 CREBBP PDGFRA NOS3 HIF1A PLCG1 PDGFB MAPK14 TIMP2 FGF2 TIMP3 AKT1 ANGPT1 TEK SMAD1 VEGFA MMP9 PTK2 PIK3CA FLT1 ARNT MAPK1 SRC SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260910%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 NRP1 ACE2 FURIN KDR VEGFA MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260910%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A KEAP1 SLC3A2 SLC7A11 SLC1A5 SLC7A5 ATF4 NFE2L2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260910%WP4752%HOMO SAPIENS Base excision repair SMUG1 NTHL1 POLE2 APEX1 XRCC1 POLE3 PARP1 FEN1 OGG1 POLB PARP3 APTX POLG POLG2 POLL TDP1 POLE ADPRS NEIL1 RFC5 RFC3 RFC4 RFC2 PARP2 RFC1 PNKP HMGB1-1 UNG POLD3 POLD4 TDG PARP4 POLD1 MPG POLD2 LIG1 PCNA MUTYH MBD4 LIG3 NEIL3 NEIL2 POLE4 MALE INFERTILITY%WIKIPATHWAYS_20260910%WP4673%HOMO SAPIENS Male infertility SLC46A1 EP300 CLU CLOCK POLG ESR1 RFC1 TNF MDM2-2 GNAO1 SOX5 HLA-DRA LIG4 ARNTL DAZL XPC MSH5 DDX20 XRCC4 KDM3A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 FAS PARP1 ATM POLB GPX1 PEMT APOB BCL2 NOS1 PMS2 MLH1 SIRPA;SIRPB1;SIRPG ETV5 MTRR ERCC1 CREBBP AR ERCC2 MTR-1 CYP1A1 MMP2 MMP9 CCNA1 CCNK IHO1 UBR2-2 SLC16A7 CYP26B1 RGS9 RAG1 NANOS1 USP8 INSR NOS2 PRDM7;PRDM9 MTHFR PRM3 SPATA17 ESR2 SOD3 MSH4 TSSK6 TSSK4 TCN2 DDX4 STRA8 UBD MOV10L1 TMEM132E BRCA2 UBE2B XRCC2 NFE2L2 CCNT1 XRCC3 PUM2 CCNT2-1 PIWIL2 AHR CRISP2 EPPIN;EPPIN-WFDC6 PIWIL1 PIWIL4 PIWIL3 SPO11 CAT SEPTIN12 YBX2 CHD2 CDK9 KLK3;KLK2 ABCB1 HORMAD2 HORMAD1 MSMB PRMT6 PACRG TEX15 AGO2 AHRR USP26;USP29 SHMT1 LTF CYP17A1 PON2 PON1 DND1 CXXC1 ABLIM1 OR2W3 PEX10 LRWD1 CDC42BPA MLH3 BHMT REC8 FOLH1B;FOLH1 CTCFL MTHFD1 TRIP13 BRDT PSAT1 SRD5A2 NQO1 NOS3 FASLG THBS1 XRCC5 H4C1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP2369%HOMO SAPIENS Histone modifications H4C6 H3-3A KMT2D KMT2C H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EZH2 AEBP2 KMT2E SETD4 SETD5 SMYD2-1 SETD3 SMYD5 SETD9 SETD6 KMT2B DOT1L SETD7 PRDM2 NSD1 SMYD1 KMT2A KMT5B SMYD4 KMT5A SMYD3 SETDB1 SUV39H1 KMT5C EED SETD1B SUV39H2 SETD1A SETMAR ASH1L SETBP1 EZH1 H4-16 SET-1 EHMT2 SETD2 EHMT1 H4C1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260910%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17RA IL17RC TLR4 IL17A ANO6 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260910%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCA CDK4 CDK2 GLB1 ASAH1 RB1 CDKN1A S1PR1 PLCB1 S1PR2 S1PR5 SPHK1 TERT SPTLC1 GBA MTOR SGMS2 SMPD3 UGCG KDSR RPP38 CERS4 E2F1 SGPP1 DEGS1 CERS2 MAPK1 PRKCB BDNF TRKB SIGNALING%WIKIPATHWAYS_20260910%WP3676%HOMO SAPIENS BDNF TrkB signaling EIF4EBP1 NRAS PLCG1 HRAS GAB1 RPS6KA1 GAB2 ARC RHEB RPS6KB1 KRAS EEF2K BDNF GRB2 DLG4 TRPC3 SOS1 SHC1-1 TRPC6 HOMER1 GRIN1 TSC2 CREB1 AKT1 MTOR PIK3CG TSC1 ADCY1 MKNK1 NTRK2 BRAF MAP2K2;MAP2K1 MAPK1 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260910%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH3 ALKBH2 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260910%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption ARHGDIB ADCY3 VAMP2 STX4 RAB5A GNAS-1 DCTN6 DCTN4 CREB3L3 CREB3L4 DYNC2H1 CREB5 CREB3L1 DYNC1H1 DYNC1I2 PRKACB-1 RAB11B ADCY6 CREB3L2 DYNC2LI1 PRKACA-1 AVPR2 DCTN1 DYNC1LI1 DYNC1LI2 RAB5B CREB1 RAB5C ARHGDIA ADCY9 DYNC1I1 AVP ARHGDIG NSF CREB3 DCTN5 DCTN2 AQP4 RAB11A AQP2 AQP3 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260910%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 H3-3A SMARCD2 SMARCD3 DPY30 RBBP5 PAXIP1 WDR5 KDM6A KMT2C SMARCC1 RXRA MBD5 SMARCC2 NCOA6 ACTL6A ARID1B ASXL1 BAP1 SMARCB1 NR1I3 SMARCA2 ASH2L ARID1A SMARCA4 ACTL6B PAGR1 EHMT1 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260910%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 NPAS2 POLR1E CREBBP CREB1 DDX21 NCOA3 FBL IRF2 ALX1 MAFG PCNA CLOCK SMAD4 FOXO1-1 ARNTL IL19 SIGNALING%WIKIPATHWAYS_20260910%WP5422%HOMO SAPIENS IL19 signaling MAPK3 JAK1 MAPK8 COL1A1 STAT1 MAPK14 STAT3 MMP1 TNFRSF1A IL20RA IL20RB IL19 MUC5AC CXCR4 SOCS5 CCL11 IL4 TNF AKT1 CCNB1 SOCS1 ACTA2 STAT6 IL4R TGFB1 NFKB1 MAPK1 RAC1 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260910%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway BMP4 IL6R DKK1 NOTCH1 TPO WNT7B NODAL WNT1 WNT2 HGF TF IL6 NTF4 TNFSF11 FLT3LG GDF5 ALK INS;INS-IGF2 EGF EPO PDGFA KITLG WNT3A WNT5A CNTF FGF10 PDGFB WNT2B FST FGF2 LEFTY2;LEFTY1 IL11 NOG SHH CSF1R FGF1 IL3 CSF1 FGF4 INHBA FGF8 CXCR1 VEGFA KIT TGFB1 TGFB3 NT5E IGF1 CREATINE PATHWAY%WIKIPATHWAYS_20260910%WP5190%HOMO SAPIENS Creatine pathway GATM CKB GAMT OAT SLC6A8 CANCER PATHWAYS%WIKIPATHWAYS_20260910%WP5434%HOMO SAPIENS Cancer pathways ADCY8 RXRA STAT5A EGF FN1 PRKACB-1 ESR1 TXNRD3 CCND1 MYC RUNX1 ERBB2 HHIP GNAI3 PDGFB GNAI2 RPS6KA5 PTCH2 GLI2 SHH KIF7 IGF1 BMP4 BMP2 MAPK8 CASP8 FADD TPM3 GSTT2B;GSTT2 GSTM1;GSTM2-1 TGFBR1-1 MMP3 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 IL13RA1 FZD1 FZD3 WNT3A WNT5A WNT7A WNT3 LRP6 AKT2 AKT3 AKT1 MTOR AGTR1 GSK3B HDAC1 PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 EPAS1 RAC1 JAK2 LPAR2 LPAR3 IL6R LPAR4 GNG10 MAPK3 JAK1 NCOA1 GNG13 CREBBP STAT1 TXNRD1 LPAR5 BAD LPAR6 SPI1 STAT3 GNGT1 AGT MMP1 IKBKG RUNX1T1 KEAP1 IL6 IGF1R RPS6KB1 FRAT2 GRB2 SKP1 IL6ST SOS1 BCL2L1 VEGFB VEGFD TCF7 DVL1 CXCL8 DVL2 KITLG DVL3 CSF3R IL2 ESR2 IL4 IFNG SP1 PDGFRA F2R FLT4 IL12A COL4A2 PTEN COL4A1 BRCA2 COL4A4 POLK FZD10 APC2 COL4A6 NCOA3 FGF1 CSF1R AXIN1 SOS2 LEF1 EGFR HSP90B1 E2F2 HES1 E2F3 PRKCG BAK1 HES5 TCF7L2 TCF7L1 KLK3;KLK2 WNT5B PRKCB HEYL GNB2 APC PRKCA GNB1 RPS6KB2 GNB4 SMO GNB3 IL7R NOTCH2 NOTCH3 NOTCH1 HSP90AB1 LAMC3 NOTCH4 LAMC2 PIK3R3 LAMC1 HSP90AA1 WNT6 WNT1 WNT2 WNT4 JAG2 MST1 WNT10B WNT10A IL3RA CXCR4 SMAD4 FZD2 CXCL12 JAG1 LAMA5 FZD5 LAMA2 FZD4 TRAF3 LAMA1 FZD7 CCDC6 LAMA4 PTCH1 LAMA3 FZD6 FZD9 STAT4 SMAD2;SMAD3 FZD8 GNG2 IL12RB1 GNG5 IL12RB2 IFNGR1 FGFR4 GNG4 GNG8 FGFR3 IL23A FGFR2 LAMB3 FGFR1 LAMB2 WNT2B LAMB1 BCL2L11 PIK3CD EPOR PIK3CB GLI3 FASLG HEY1 HEY2 WNT9B WNT9A CDKN2A WNT16 PIK3CA PPARG RASSF1 LRP5 WNT8A PGF WNT8B DLL1 DLL3 DLL4 MAPK9 WNT11 WNT7B MAPK10 PPARD CTNNB1 RB1 CDKN1A CDKN1B BBC3 GLI1 FLT3LG CASP9 TFG CCND3 DAPK2 CCND2 DAPK3 EML4 CASP3 MECOM APPL1 FH MAX NKX3-1 PLEKHG5 APAF1 TRAF4 CCDC42 BIRC7 BIRC2 BIRC3 DDB2 RASSF5 RALGDS CCNE2 RASGRP2 CSF2RA RASGRP4 CCNE1 PLD2 RASGRP3 TP53 GNB5 MDM2-2 CKS1B CYCS-1 ARHGEF11 ARHGEF12 DCC DAPK1-1 ABL1 RALB ADCY1 E2F1 LAMB4 RBX1 PMAIP1 MSH6 BID CTBP2 MSH2 GADD45B MSH3 GADD45A PML GADD45G CDK6 ARNT2 RAD51 CDK4 CDK2 FAS BAX FOXO1-1 FLT3 IL2RG STAT6 TGFB2 IL4R TGFB1 ARNT TGFB3 NFKB1 MLH1 NFKB2 TGFBR2 TRAF6 IL2RA IL2RB GNA11 NTRK1 IL12B RET EDN1 HGF MMP2 IL13 IL5RA CSF2RB PLD1 CCNA1 VHL PDGFA TGFA TERT HMOX1 CDKN2B IL5 NFE2L2 PTGER4 PTGER2 CASP7 VEGFA EDNRA EDNRB PTGER1 PTGER3 ADCY3 CAMK2B GNAI1 CAMK2D NRAS IGF2 HIF1A CAMK2A HRAS CAMK2G RALBP1-1 GNAS-1 RALA-1 GNAQ KRAS PTGS2-2 BDKRB2 ALK ETS1 CRKL MET COL4A3 COL4A5 F2RL3 ELK1 IKBKB EP300 JAK3 CHUK FOS CEBPA CBL RELA CALML6 CALML3 CALML4 STAT5B NFKBIA EPO PDGFRB AXIN2 KIT CTBP1 EGLN1 EGLN3 EGLN2 PLCB3 PLCB4 PLCB1 PLCB2 JUN BCL2 RXRB RAF1 RXRG MGST3 MGST1 MGST2 NCOA4 AR GSTM4 GSTM3 TRAF2 ADCY4 ADCY2 ADCY7 ADCY6 NOS2 ADCY5 ADCY9 GSTO2 GSTO1 GNA13 GNA12 ARHGEF1 BCR PIM2 GSTP1 RASGRP1 KNG1 XIAP TRAF1 GSTA4 ITGA2B ARAF BIRC5 BDKRB1 BRAF PTK2 PIM1 ITGB1 CUL2 RAC3 ITGAV ELOC-1 ITGA3 ITGA2 ELOB JUP ZBTB16 ITGA6 SKP2 CRK ROCK1 ROCK2 CUL1 ZBTB17 IL15 IL3 CCNA2-1 IL7 HDAC2 TRAF5 CDH1 CTNNA1 CTNNA3 CTNNA2 IFNAR2 STAT2 IFNGR2 IFNAR1 RARA RARB PLCG2 F2 TPR MITF TXNRD2 SLC2A1 LPAR1 PLCG1 RHOA PRKACA-1 NQO1 VEGFC PAX8 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5102%HOMO SAPIENS Familial partial lipodystrophy MAPK9 ICMT LMNA ZMPSTE24 KLF9 SREBF1 LMNB1 FNTA CEBPA PNPLA2 INS;INS-IGF2 STAT5B LIPE BANF1 FABP4 AKT2 GATA3 GATA2 KLF2 KLF5 PPARA PRRX1 CIDEA CIDEC PIK3CA PPARG LMNB2 LPL PLIN1 MGLL BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260910%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment MAPK7 IKBKB PDPK1 MAPK11 CTNNB1 CHUK RAPGEF1 CASP9 CRK NFKBIA ROCK1 ROCK2 CDC42 PAK1 MYC APAF1 DOCK7 CREB1 ARHGDIA YWHAE TP53 YWHAB YWHAQ CYCS-1 YWHAH MKNK1 SMPD1 MAP3K3 ARHGAP35 TIAM2 PARD3 IQGAP3 NPTX2 WASL RND3 PARD6B LINGO1 SORT1 MAPKAPK2 KIDINS220 MAPK8 CASP8 BAX TRADD FADD MAP2K7 IRS1 EIF4E IRS2 BDNF EEF2K JUN MAP3K1 BCL2 EEF2 RAF1 AKT1 MAP3K5 MTOR GSK3B YWHAG YWHAZ MAP2K2;MAP2K1 MAPK1 RAC1 EIF4EBP1 TRAF6 MAPK3 NGFR MAP2K4 BAD PRKCD STAT3 GAB1 PTPN11 IKBKG RTN4R RPS6KB1 GRB2 SOS1 SHC1-1 TCF7 SH2B2 CFL1 BMP7 LEF1 PRKCG PRKCI TCF7L2 PRKCH TCF7L1 PRKCB PRKCE PRKCA RPS6KB2 NRAS PLCG1 PRKCZ HRAS RHOA KRAS PARD6A CFL2 STMN1 LIMK1 TIAM1 DIAPH1 FOXO3 BCL2L11 PIK3CD PIK3CB RAP1B PIK3CG TP73 FRS2 MAP2K5 NTRK2 PIK3CA REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling IRF3 MAPK9 CYLD MAPK14 MAPK12 MAPK13 IKBKB MAPK10 MAPK11 CHUK FOS RELA NFKBIA PTPN6 PLK1 TNF IFNB1-4 IRAK1 IRAK2 MAP3K8 TOLLIP TAB3 CXCL11 TAB2 TAB1 MYD88 IL1B USP7 FBXW5 CD180 TRAFD1 RNF41 MAPK8 SIGIRR RBCK1 CASP8 LY96 RNF216 CUEDC2 SFTPD RIPK1 IRAK3 FADD MBL2-1 TICAM1 PELI1 ZMYND11 RNF31 MAP2K7 PELI3 PELI2 CTNNAL1 MAP2K6 SARM1 MAP2K3 JUN IFNAR2 CCL5 AKT2 AKT3 CD86 AKT1 TMED7 CD80 IFNAR1 SOCS1 CISH PIK3R2 PIK3R1 IRAK4 NFKB1 MAP2K2;MAP2K1 NFKB2 MAPK1 RAC1 CXCL10 TRAF6 MAP3K7 MAPK3 MAP2K4 STAT1 IL12B IKBKG LBP IL6 CCL3L1;CCL3L3;CCL3;CCL18 SYK BTK CXCL8 CCL4L2;CCL4L1;CCL4 TICAM2 SPP1 TIRAP TLR1 TLR9 TLR8 TLR6 IL12A TLR7 TLR4 TLR3 CXCL9 IRF7 SQSTM1 PIK3R3 CD14 PIK3R5 TRAF3 CD40 TIFA TNFAIP3 TREM1 TLR5 TLR2 MLST8 PIK3CD PIK3CB PIK3CG IRF5 SMAD6 TBK1 OTUD5 PIK3CA IKBKE ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment CHUK IKBKG IL6 RELA MUC1 NFKBIA TNF NFKB1 IKBKB NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260910%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY6 LPAR4 ADORA1 P2RY4 ADORA2B P2RY2 ADORA3 P2RY1 LPAR6 LTB4R ADORA2A OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260910%WP3287%HOMO SAPIENS Overview of nanoparticle effects CDH3 PTGS1 HMOX1 BAX COL4A1 PIK3CD TNF AKT3 ITGAD IL6 CRP PTGS2-2 PTK2 NFRKB CCND3 LAMA3 FN1 BCL2 CXCL8 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260910%WP4564%HOMO SAPIENS Neural crest cell migration during development NGFR CDH11 PIK3R4 PIK3R3 STAT3 PIK3R6 PIK3R5 RHOA FOS MMP2 BDNF TRIO JUN MMP9 EPHB6 EPHB1 EPHB3 NGEF MMP8 BUB1B-PAK6;PAK6 PAK1 PAK5 PAK3 PAK2 PAK4 TIAM1 EPHB2 PIK3CD AKT2 AKT3 PIK3CB AKT1 EPHB4 F2RL2 PIK3CG PIK3CA ARF1 RAC1 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer GOT1-1 SLC2A1 SLC1A5 HK2 BCKDHA GLS2 LDHA PKM HK1 SLC16A1 GLUD1;GLUD2 DLAT SLC7A5 KRAS CARM1 DLD UAP1 PDHB BCAT2 FASN SLC43A1 LDLR PDHX ME1 PGM3 HMGCS2 SLC16A4 GPT RPIA PFKL SOAT1 PDHA1 RPE;RPEL1 ACLY GNPNAT1 TP53 GFPT1 HMGCR CS MDH1 GOT2-1 GPI LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260910%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 CREB3L2 IL1B CREB1 MAPK14 CD14 MAPK12 TLR4 MAPK13 ATF4 MAPK11 CCL13;CCL2 IL6 REL RELA CREB3 CREB3L3 RELB CREB3L4 CREB5 CREB3L1 IL10 NFKB1 NFKB2 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260910%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 PRKAA1 ADIPOQ LEPR ACACA PRKAG1 ADIPOR1 ADIPOR2 LEP CPT1A SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260910%WP15%HOMO SAPIENS Selenium micronutrient network SCARB1 SERPINA3 SERPINE1 PLAT FLAD1 TXNRD1 MTR-1 RFK MPO GPX6 ICAM1 SAA2;SAA1 CBS;CBSL FGB PRDX1 FGA SAA2-SAA4;SAA4 FGG IL6 APOA1 F2 RELA F7 PLG HBD;HBB LDLR ABCA1 TXNRD3 INSR MTHFR SOD2 SOD3 SOD1 IFNG HBA2;HBA1 CTH ALB TNF PNPO KMO CAT XDH KYNU TXNRD2 IL1B PTGS1 ALOX5 ALOX15B ALOX5AP GPX1 GPX4 PTGS2-2 GSR INS;INS-IGF2 APOB GGT1 SEPHS2 SELENOO SELENON SELENOS SELENOT SELENOK SELENOI PRDX3 SELENOP PRDX2 PRDX5 PRDX4 DIO1 DIO3 CCL13;CCL2 CRP NFKB1 TXN NFKB2 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL1RL1 IL13RA1 IL4 STAT3 IL33 TSLP IL5 FCER1G TYK2 IL31RA JAK3 FCER1A DEFB103A;DEFB103B IL2RG MS4A2 OSMR CRLF2 STAT6 IL13 IL4R IL25 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260910%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases SMAD2;SMAD3 PPP3CA NFATC1 RXRA MAPK14 TNF MED14 VDR IKBKB DUSP1 CHUK IKBKG PPP3R1 IL6 SMAD4 RELA MAP2K6 MAP2K3 NR3C1 MAP3K1 NFKBIA NFKB1 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome TJP3 TJP2 PRKAA1 CTNNB1 TJP1 GJA1 FMO5 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PRKAB2 PRKAB1 F11R GJA3 KIRREL1 AMELY;AMELX ACP6 GJA5 OCLN-1 GJA8 CHD1L PYGO1 PYGO2 BCL9 AFDN CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260910%WP2023%HOMO SAPIENS Cell differentiation expanded index RUNX2 MEF2A MEF2B;BORCS8-MEF2B KLF4 TLX3 TLX2 MEF2D PAX7 ID2-1 TLX1 LEFTY2;LEFTY1 STAT3 EZH2 HDAC5 SOX2 MEF2C MYOD1 SRF PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260910%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing IRF3 RNASEH2C RNASEH2B RNASEH2A MAVS TREX1 RNASEL RNASET2 STING1 ADAR SAMHD1 IFNB1-4 OAS1 CGAS IFIH1 DDX58 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies IL2 F2RL1 IFNG ITGB7 ITGA4 TNF DHODH IL15 CD4 EGFR IL21 GZMH;GZMB-1 TGM2 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260910%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer SLC2A1 SLC1A5 PYCR2 LDHA GLS GAPDH-1 PGAM1 PKM PGK1 ENO1 PSPH HK3 PYCR1 SLC16A3 IDH3A IDH2 TIGAR TALDO1 PAICS GLUD1;GLUD2 G6PD ACO2 TKT PSAT1 SHMT2 PDHB SDHB FASN FH DLST RPIA PFKL ALDOB PDHA1 ACLY SUCLG2 MDH2 GOT2-1 GPI PGD NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260910%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway DEPTOR ATG16L1 PLA2G6 PRKAA1 MECP2 ATG101 FTL-1 PIK3R4 RHEB WDR45 RB1CC1 DCAF17 C19orf12 ACACA WIPI1 GTPBP2 WIPI2 CP COASY FA2H BECN1 ATP13A2 RPTOR STK11 ATG14 ATG13 TSC2 SCP2 MLST8 ULK1 SPTLC1 MTOR MAP1LC3A TSC1 ATG3 ATG10 ATG12-1 ATG2A AKT1S1 PIK3C3 ATG4A ATG7 ATG5 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260910%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis PRKCA CAMK2B CAMK2A NRXN3 NRXN2 MAPK14 PPARGC1A RPS6KA1 NRXN1;NRXN3;NRXN2 NGF BDNF CAMKK2 CCND2 HNRNPL BCL2 CAMKK1 SYT2 SYT12 DRD1 CREB1 RPS6KA5 CAMK4 PRL NCAM1 CALM1 MAPK1 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260910%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSG ACE CTSD CMA1 REN MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260910%WP2003%HOMO SAPIENS miR targeted genes in leukocytes WDR11 LAMTOR3 TUSC2 PKM ARID4B MAPK14 CTNNB1 WDFY1 MATR3 SLC1A4 CORO1C RAB6A ANAPC1 CD164 SLC25A1 SNAP23 TNFAIP2 TMEM109 ACP2 SCYL1 GNAI2 ARHGDIA RFT1 YWHAQ MAP3K8 PDLIM5 CDK6 TUBA1A ACAA2 ARF4-1 ZEB1 SRSF10 CDIPT ANXA2 TPM3 G6PD GOLGA7-1 TNFSF9 IDH1 RAB34 TMED10 ADIPOR2 MRPL20 BCL2 ANPEP DDX5 ATP6V1F TBCA HNRNPM TRAM1 ADAR RDH10 MRC2 SPTLC1 SH3BGRL3 USP1 SEC24A PPIF CAPG PRPF40A POM121;POM121C PPIB PNP-1 POLE4 IFRD1 DNAJB1 POLR2C RTN4 TXNRD1 CAP1 PHC2 AP3D1 ARCN1 IGF2R CSRP1 FMNL2 GYS1 ATP6V0E2;ATP6V0E1 PLXND1 SLC7A11 ATP2A2 TXN2 CEBPB SERPINE2 C1orf56 DCAF7 KCNN4 TMEM43 SAC3D1 HMOX1 ADPGK PRSS21 PTRH1 UNC93B1 GNA13 NELFCD MCL1 TYMS CHORDC1 CDK5RAP1 MTHFD2 VPS39 CDK5RAP3 ATP6V0A1 SNX6 SFXN1 PTPA FADS1 RAB5C PISD TMED3 CTSC BCL6 RHOG GAK THBS1 SLC7A6 CDCP1 FRG1 BRPF3-1 MPDU1 LMNB2 LPL SHOC2 CA12 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260910%WP5496%HOMO SAPIENS Targeted therapy in breast cancer MAPK3 NRAS PIK3R4 ERBB3 PIK3R3 ERBB4 HRAS PIK3R6 PIK3R5 KRAS RAF1 ERBB2 PIK3CD AKT2 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A PIK3CG PIK3C2B EGFR PIK3R2 PIK3R1 PIK3CA MAPK1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260910%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway ITGB2 C1QC RAC3 PLCG2 PIK3R3 VAV3 PIK3R6 FCGR1A VAV1 VAV2 HCK NCF2 TREM2 LYN SYK PTPN6 C1QB TREM1 NCF1 TYROBP LAT ARPC1B NCF4 PIK3CD SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 CYBA PIK3CB FCER1G PIK3C2A PIK3CG CYBB PIK3R2 PIK3R1 PIK3CA NCKAP1L PIK3C3 ITGAM RAC1 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260910%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOA4 APOA5 LIPC APOC2 SCARB1 CYP7A1 PLTP FDFT1 APOA1 MTTP APOE APOB LDLR ABCG8 ABCA1 ABCG5 SQLE APOC3 SOAT1 DGAT1 ACSS1 APOC1 PDIA2 HMGCR CETP LRP1 APOA2 LPL LCAT PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260910%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma KDM6A CREBBP ARID4B EP300 SMARCE1 CEBPA BRCA1 CHEK2 CHEK1 MAX TLK1 MYC ERBB2 SMC1A ARID5B FGF16 PTEN ARID1A TP53 JMJD1C MYB NCOR1 MYBL1 CMTR2 UHRF1 MAGI1 BRD1 INSRR IL17RD MORF4L1-2 FOXP2 MYCN KAT6A CTBP1 MAML3 DTX4 FBXW7 CNTN6 MGA MYCBP-1 H2AC16;H2AC11 H1-4 KANSL1 NFIB NOTCH1 KMT2C PRKDC KDM6B HRAS ATM BCOR SRCAP RAF1 NSD1 FGFR4 SMARCA2 ERBIN FOXO3 AKT1 BCORL1 ATRX MAGI2 PIK3CA MAP2K2;MAP2K1 SETD2 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260910%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC22A2 SLC31A1 HEART DEVELOPMENT%WIKIPATHWAYS_20260910%WP1591%HOMO SAPIENS Heart development BMP4 BMP2 GATA6 TBX20 BMP10 NKX2-5 NOTCH1 IRX4 TBX2 HAND2 TBX5 ERBB3 FOXC2 FOXC1 PITX2 PTPN11 GATA4 HAND1 NFATC2 CTNNB1 SMAD1 SMAD4 VEGFB FOXA2 SMYD1 TBX1 NFATC1 BMPR1A FGF10 BMPR2 FOXH1 SHH BHLHE40 HEY1 VEGFC HEY2 FGF8 VEGFA MEF2C NFATC3 ISL1 NFATC4 MAPK1 SRF NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260910%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation IL1B PYCARD CASP1 CTSB TLR4 NFKB1 NOX1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260910%WP4146%HOMO SAPIENS Macrophage markers CD68 F3 CD74 CD163 CD14 CD83 LYZ-1 CD86 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260910%WP4504%HOMO SAPIENS Cysteine and methionine catabolism GOT1-1 CSAD AHCY MTR-1 CTH CDO1 MPST SQOR CBS;CBSL SUOX BHMT ETHE1 MAT1A GSS GCLC SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260910%WP4496%HOMO SAPIENS Signal transduction through IL1R MYD88 TRAF6 MAP3K7 IL1B MAPK8 MAPK14 IKBKB IRAK3 CHUK IL1RN IL6 RELA MAP2K6 MAP2K3 JUN MAP3K1 NFKBIA IL1A IL1R1 ECSIT TNF IFNB1-4 IL1RAP IRAK1 IRAK2 TGFB2 TGFB1 TGFB3 TOLLIP NFKB1 TAB1 MAP3K14 TRANSLATION FACTORS%WIKIPATHWAYS_20260910%WP107%HOMO SAPIENS Translation factors EIF4EBP1 EEF1A1 PAIP1 EIF4EBP2 EIF2S1 EIF2S2 EIF4G1 EIF2S3;EIF2S3B EIF1 EIF4A2 EIF3C;EIF3CL GSPT2 EIF5 EIF4H EIF4E EIF3I EIF2B1 EIF1AY;EIF1AX EEF2K EEF1B2-1 EIF3J EIF2B5 EIF3G EIF2B4 EIF3H EIF5B EIF3E EIF2B3 EIF3F CLUH EIF3D EIF5A;EIF5AL1 EIF3A EEF1G EIF3B EEF2 EIF6 EEF1D EIF2B2 EEF1A2 ETF1 PABPC1;PABPC3 EIF4G3 EIF4B EIF2AK1 EIF2AK3 EIF2AK2 EIF4A1 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260910%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling MAPK9 MAPK7 PRKAA1 MAPK14 VAV3 ELK1 IKBKB PDPK1 MAPK10 EIF2S2 CTNNB1 CHUK VAV2 RELA PRKAA2 STAT5A STAT5B NFKBIA CASP3 SRC CDC42 CREB1 RAB3A YBX1 RPS6KA5 CAMK1 NSF IGF2BP1 GRIN2B RASGRF1 LINGO1 SORT1 CDK5 KIDINS220 GRIA3 MAPK8 CRTC1 RPS6KA3 RPS6KA1 MAPT IRS1 EIF4E IRS2 BDNF NCF2 JUN MAP3K1 ACACB PPP2CB;PPP2CA EEF2 RAF1 CDKL5 GRIN1 TSC2 CDK5R1 SYN1 FYN AKT1 MTOR ADAM17 GSK3B RPS6 PIK3R2 PIK3R1 NFKB1 MAP2K2;MAP2K1 MAPK1 SIRPA;SIRPB1;SIRPG RAC1 JAK2 EIF4EBP1 RACK1 TRAF6 MEF2A NCK2 MAPK3 NGFR MAP3K2 STAT1 NTRK1 BAD PRKCD NTRK3 STAT3 EIF2S1 PTPN11 IKBKG CDH2 RPS6KB1 GRB2 SHC4 SHC1-1 SHC2 SH2B2 CFL1 NCF1 CSNK2A1;CSNK2A3 PTK2B GABRB3 MEF2C SQSTM1 NFATC4 APC GRIP1 CYFIP1 GRIA1 PLCG1 CAMK2A GRIA2 HRAS NGF DLG1 CNR1 NCK1 DPYSL2 FRS3 DOK5 KCNN2 TIAM1 DOCK3 KCNA3 PTPRF NTF3 SH2B1 RANBP9 FOXO3 MARCKS CAMK4 SHC3 RHOG RAP1A FRS2 MAP2K5 KSR1 NCAM1 NTRK2 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260910%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction ACE2 IFNAR1 TNFRSF1A ICAM1 TNF NFKB1 NOX1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C18-1 CYP2B6 CYP2C9;CYP2C19 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260910%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis MED15 NR1H3 SREBF2 PRKAA1 SCD PPARGC1A SIRT1 MTOR HMGCR HMGCS1-1 SREBF1 SIRT6 PPARA FASN LDLR ABCA1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260910%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC3 SLC51A SLC51B ABCC4 SLC10A1 ABCC2 ABCB11 SLC10A2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FABP6 ABCB1 NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP61%HOMO SAPIENS Notch signaling JAK2 DLL1 PSEN1 DLL3 DLL4 NCOR2 SNW1 STAT3 EP300 NUMB NUMBL SKP1 SRC CUL1 ITCH APH1A RBPJ NCSTN NCOR1 APH1B FHL1 HES1 HES6 HES5 MAML3 FBXW7 TLE1 HDAC2 NOTCH2 NOTCH3 NOTCH1 PSENEN NOTCH4 JAG2 JAG1 LCK MAML2 MAML1 AKT1 CIR1 MTOR RING1 SAP30 DTX1 ADAM17 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 HEY2 SPEN GSK3B HDAC1 PIK3R2 PIK3R1 PSEN2 NFKB1 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260910%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A1 GCG IL6R IL6 GLP1R SLC2A2 INS;INS-IGF2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260910%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets TCF4 RUNX2 CSF2 TPO ID2-1 SPI1 STAT3 CSF1 IRF4 IRF8 BATF3 FLT3LG IKZF1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260910%WP400%HOMO SAPIENS p38 MAPK signaling RASGRF1 MAP3K7 MAPKAPK2 MAP2K4 STAT1 MAPK14 ATF2 HRAS TRADD ELK1 PLA2G4A RIPK1 MAP3K9 MAP2K6 GRB2 TRAF2 MAP3K1 TGFBR1-1 DDIT3 SHC1-1 MAX CDC42 MYC MEF2D CREB1 RPS6KA5 MAP3K5 HSPB1 DAXX MKNK1 TGFB2 HMGN1 MAPKAPK5 SMIM40 RAC1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260910%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling WDR74 SKAP1 CFP BTN3A1;BTN3A3 APOM APOH HP;HPR VPS11 TPO VPS16 INTS4 TOMM70 HRG CTSZ UPF1 SDF2 GP1BA ATP13A3-1 IL16 OS9 SERPINA5 SRP72 MIB1 FOS LRG1 ACTG1 CCL27 RHEB CCL26 RRM2-1 SRP19 STEAP3 CLCC1 TLE3 VPS33A ADAM9 G3BP1 FN1 G3BP2 CFB NPTX1 PTPN6 MDN1 FAM83A NEK9 HSPA8 C1S GGH C1R TP53I3 CFI PF4;PF4V1-1 LGALS3BP ATG13 TRO SELP LARP1-1 TRIM59 SRP54 ITIH4 ITIH3 ULK1 RAP1GDS1 FGF2 ERLEC1 TNF CCL8 CXCL13 UGGT2 ATE1 C8A ACTB-1 COL7A1 VPS41 FAM98A CFH-3 IRAK1 CXCL2;CXCL3;CXCL1-1 CCL21 MYD88 IL1B MAPK8 CASP8 CD226 CCL22 MMP25 EIF4E JUN BST2 IFITM3;IFITM2;IFITM1 LCK CD8A CD8B;CD8B2 MOV10 AKT1 MTOR ACE2 SIGMAR1 CRP DDIT4 GTF2F2 RAC1 JAK2 JUNB JAK1 RTN4 STAT1 CD3G PRG3 CD3E DUSP1 CD2 NKRF AGT IKBKG CD247 LBP IL6 RRAS TRAF2 IL10 CARD11 CCL11 CXCL8 IL18 IL4 IL1A IFNG IL12A ITCH IGFBP3 TLE1 PRKCQ CD14 SMAD1 IL21 IL22 CXCL12 TRAF3 IL18RAP SMAD5 BIRC5 IFI44L IFIH1 TBK1 IGLL5;IGLL1 DDX58 IRF3 TRPM2 MAVS CASP5;CASP4 TBKBP1 ITGA3 CASP9 EGR1 CASP3 APOD CCR6 CCL1 IL33 CCL20 IFNB1-4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 CCNB2 IL7 CCNB1 HLA-DRA APOL3;APOL4;APOL1;APOL2 BID CDK1 CCL23;CCL15 PARP2 ATP6AP1 NLRP1 CCL5 IFIT1 FYN PIAS1 MX1-1 IRF9 CCL13;CCL2 CTSD RPS6 ZAP70 NFKB2 TGFBR2 CXCL10 EIF4EBP1 TRAF6 SERPINE1 NTRK1 SAA2;SAA1 FGB FGA FGG APOA1 IL13 CCL3L1;CCL3L3;CCL3;CCL18 HBD;HBB CEBPB C1QBP CCL4L2;CCL4L1;CCL4 IL9 PMPCB ALB IL5 APOC1 CXCL9 IL1R2 AHR PITRM1 MAP1LC3B2;MAP1LC3B-1 NLRP3 GABARAPL2 NFATC3 IL17A DEPTOR HIF1A CTSB CD163 GSN EIF4A2 TF PTGS2-2 CPN1 CTSV;CTSL RPTOR MARK2 CCR5 MLST8 CAMK4 CXCR1 CXCR2 TNFSF10 CXCL5;CXCL6 AKT1S1 GTSE1 APOA2 VPS36 VPS18 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer SMARCD1 SMARCD2 SMARCD3 HSD17B2 SMARCC1 SMARCC2 ACTL6A MAPK14 ARID1B ELK1 RB1 CDKN1A CDKN1B FOS MRE11 RHEB RAPGEF1 BRCA1 ERG CASP9 CDC25B CRK DOCK1 CHEK2 CASP3 CHEK1 CCND1 PAK1 MYC CDC25A PLK1 ARID1A TP53 MDM2-2 F13B SPINK1 FKBP5 BLM BARD1 E2F1 NOXA1 MSH6 RICTOR SPRY1 MSH2 RASA1 RAD50 CDK4 CDK2 CDK1 MAPK8 CASP8 BAX ATM SPRY2 ATR HSD17B7 FOXA1 ABCC4 JUN BCL2 RAF1 TSC2 SMARCA4 AKT1 MTOR ETV4 MAP2K2;MAP2K1 MAPK1 EIF4EBP1 MAPK3 JAK1 AR STAT1 BAD STAT3 GAB1 PTPN11 MMP1 HGF GRB2 SOS1 SP1 PTEN CDKN2B EIF4E1B HSD17B4 HSD17B1 PTK2B KLK3;KLK2 CYP17A1 PRKDC HRAS MAP4K1 CPN1 CRKL SMAD2;SMAD3 RPTOR ATF1 HSD17B3 HSD3B1;HSD3B2 ACTL6B PXN RAP1B TSC1 RAP1A NDRG1 CDKN2A PIK3CA ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2853%HOMO SAPIENS Endoderm differentiation GATA6 CEBPZ VAV3 CTNNB1 HPRT1 APP ZFHX4 NKX2-1 SESN1 ZBTB17 GLI2 HNF1B PAX3 SOX17 CER1 CAND1 SFRP1 WWC1 TOX3 HOXA1 CTBP2 SFMBT1 CDYL MAD2L2 RFX7 RAB38 NAA15 CTR9 TCF4 PRDM14 RTF1 ELK4 SIAH2 PBX1 FOXN3 DAB2 SP4 PAF1 TAF4B LHX1 ONECUT1 HOXC11 CDC73 CRTC1 EZH2 HHEX DUSP4 DUSP5 DUSP2 NME1 FOXA1 PAX9 BTAF1 LEO1 KDM4A SOX2 LRPPRC TNRC6C NR3C1 MAP2K3 FOXO1-1 ACACA FOXA2 PABPC1;PABPC3 SOX21 CEP250 RARG DIP2A WNT3 EOMES WDHD1 ZNF281 PIAS1 EMSY TOX WDFY2 BCORL1 MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 GDF3 TGFB1 TRERF1 NLK NABP2 TRIM71 NCAPG2 PHF6 ZIC3 TRIM5 DKK1 JARID2 SLC2A12 TET1 STAT1 PARP8 TAF5 DDAH1 CUL4B PLCH1 AEBP2 MTF2 GATA4 AHDC1 ASCC3 ZNF462 ELP4 OTX2 GRHL2 SOX7 RGS10 TCF7 C1QBP BMP7 EXT1 LEF1 TCF7L1 APC POU5F1;POU5F1B NOTCH1 NANOG;NANOGP8 LAMC1 ELAVL1 DNMT3B MIXL1 NODAL BPTF SMAD4 TBX21 SMAD2;SMAD3 BMPR1A NOG FOXH1 WNT8A PTHLH SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260910%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TRAF6 IRF3 TBK1 TOMM70 MAVS TRAF3 IKBKE IFNB1-4 DDX58 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 RAF1 ZP2 LMNA POR PTPMT1 MDH2 HSPB1 YWHAG TMEM120B RHBDD2 ZP3;POMZP3 SFN TMEM120A SSC4D DAPK2 STYXL1 G3BP1 KIF1C ZP1 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260910%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 NOS1 HBA2;HBA1 NOS3 XDH HBD;HBB MB AOX1 NRF2 ARE REGULATION%WIKIPATHWAYS_20260910%WP4357%HOMO SAPIENS NRF2 ARE regulation PRKCA PGAM5 GSTA3;GSTA5;GSTA1;GSTA2 GCLM INSR NQO1 HMOX1 MAPK8 MAF FYN EPHB2 YES1 NFE2L2 KEAP1 CUL3 SLC7A11 GSK3B RBX1 PIK3CA CEBPB GCLC SRC AIMP2 ROTENONE METABOLISM%WIKIPATHWAYS_20260910%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway S100P CPEB4 ZIC2 ANKRD1 LRRC8A ANGPTL4 RXRA NR1I3 CDKN1C NR1I2 SNAI2 CUL1 PDE4B BIRC2 BIRC3 B3GNT5 IL11 CCL20 SLC19A2 SPRY1 GADD45B POU5F1;POU5F1B ETNK2 HSP90AA1 ALOX5AP PTGS2-2 NR3C1 ACKR3-2 JUN TNFAIP3 AKAP13 EPB41L4B ARL5B THBD RGS2 ENC1 TNS4 SRGN FGFBP1 DNER EDN2 TSC22D3 SERPINB9 NAV3 ADGRF4 CDC42EP3 TGFBR3 SCNN1A PMP2 MFGE8 CCL13;CCL2 PTGES3-1 BHLHE40 SLC26A2 ABHD2 PRRG4 FGD4 SEC14L1 GPR153 SERTAD2 STOM AMIGO2 MGAM PPP1R14C CAVIN2 PLK2 DNAJC15 NFKB2 KTN1 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260910%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells FMO3 CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 AOX1 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260910%WP5061%HOMO SAPIENS Fatty acid transporters FABP2 FABP9 ACSL6 ACSL5 FABP1 FABP3 FABP5 FABP4 FABP7 ACSL1 ACSBG2 ACSBG1 SLC27A4 CD36 FABP6 ACSL3 ACSL4 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260910%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy PFKFB2 SLC2A1 SLC1A5 LDHA MAPK3 GLS PKM PGLS PPARGC1A TRAP1 SLC16A1 SLC16A3 CPT1A RPS6KA3 RPS6KA2 RPS6KA1 DLAT G6PD GPX4 DLD GSR MITF RAF1 ARAF RPTOR LDHB PDHA1 MLST8 PKLR ACSS1 MTOR NAMPT BRAF MAP2K2;MAP2K1 MAPK1 SPINAL CORD INJURY%WIKIPATHWAYS_20260910%WP2431%HOMO SAPIENS Spinal cord injury PLA2G5 PLA2G6 PLXNA2 RB1 CDKN1B FOS GJA1 LGALS3 ROS1 EGR1 CASP3 ROCK2 C1QB CDC42 CCND1 MYC VIM SELP CD47 AIF1 TNF TP53 MBP SOX9 E2F1 RGMA OMG CXCL2;CXCL3;CXCL1-1 NTN1 E2F5 GADD45A NOX4 MAG IL1B PPP3CA CDK4 PLA2G2A-1 GDNF CDK2 CCNG1 CDK1 BDNF NR4A1 MMP12 GRIN1 NOS1 IL1R1 LTB4R CCL13;CCL2 SLIT2 TGFB1 MAPK1 RAC1 CXCL10 MAPK3 RTN4 CHST11 NGFR APEX1 RHOB ZFP36 SEMA6A MIF ICAM1 PDYN BCAN KLK8 LEP LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 BTG2 CCR2 NCAN RTN4R TNFSF13B ANXA1 IL6 TACR1 RHOC VCAN LTB ACAN MMP9 SLIT1 AQP1 SLIT3 XYLT1 C5 CXCL8 GAP43 NOS2 IL2 GFAP IL4 IL1A IFNG COL4A1 TLR4 EGFR PRKCA EPHA4 EFNB2 RHOA PTGS2-2 PTPRA FOXO3 COL2A1 PTPRZ1 FKBP1A CSPG4 AQP4 ARG1 INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260910%WP4558%HOMO SAPIENS Interferon mediated signaling PRKCA JAK2 IFNE IFNGR1 IFNK IFNAR2 JAK1 STAT2 IFNGR2 IFNG STAT1 IFNB1-4 IL10RB TYK2 IRF9 IFNAR1 PIK3R1 PIK3CA IFNLR1 IFNL2;IFNL3;IFNL1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260910%WP47%HOMO SAPIENS Hedgehog signaling SMO GRK2 PTCH2 DHH IHH GLI2 KIF7 SHH GLI3 SIN3A GLI1 ARNTL PTCH1 STK36 SAP18 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260910%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAPK3 MAP2K4 YAP1-1 PDK1 AKT1 MTOR RHOA GNAQ MAP2K5 MAP2K7 MAP2K6 MAP2K3 TRIO PIK3CA NFKB1 MAP2K2;MAP2K1 AMOT MAPK1 RAC1 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260910%WP3871%HOMO SAPIENS Valproic acid pathway IVD EHHADH-1 CYP2B6 HDAC1 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 ABAT HSD17B10 ACADSB HADHA CYP2C9;CYP2C19 ACSM1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260910%WP3935%HOMO SAPIENS Leptin insulin signaling overlap SOCS2 JAK2 INSR IRS4 DGKZ PIK3R3 STAT3 PDPK1 LEP AKT1 PIK3CG SOCS1 IRS1 IRS2 LEPR INS;INS-IGF2 SOCS3 AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260910%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension HAL UROC1 AMDHD1 GPT2 GLUD1;GLUD2 FTCD CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260910%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy CAVIN1 AGPAT2 BSCL2 LPIN3 DGAT2 DGAT1 HIF1A GPAT3 FYN AKT2 IRS1 CAV1 GRB2 PIK3CA LPIN1 INS;INS-IGF2 LPIN2 ITGB4 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAPK9 ANGPTL8 MAPK7 PRKAA1 MAPK6 RXRA MAPK4 MAP4K5 MAPK14 MAPK12 MAPK13 PDPK1 MAPK10 MAPK11 RHEB RAPGEF1 CBL PRKAA2 PRKAG1 CRK PRKAG2 PRKAG3 PRKAB2 PRKAB1 RPS6KA5 MAP3K8 RICTOR MAP3K3 GSK3A MAP3K14 NR1H3 MAPK8 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RPS6KA3 RPS6KA2 RPS6KA1 SREBF1 MAP3K9 MAP2K7 IRS1 EIF4E MAP3K4 IRS2 MAP2K6 MAP2K3 FOXO1-1 INS;INS-IGF2 MAP3K1 FASN ABCG8 ABCG5 MAP3K10 RAF1 MAP3K11 SREBF2 SCD TSC2 IRS4 AKT2 AKT1 CBLC MAP3K5 MTOR RPS6KA4 MAP3K6 GSK3B PIK3R2 PIK3R1 MAP3K13 MAP2K2;MAP2K1 MAPK1 FLOT1 FLOT2 EIF4EBP1 MINK1 CBLB MAP3K7 PTPN1 RHOQ MAPK3 CYP2B6 MAP2K4 MAP3K2 CAP1 MAP3K12 GYS1 RPS6KB1 SOS1 SHC1-1 SHC2 INSR SESN3 MAPKAP1 EXOC7 TRIP10 SOS2 SLC2A1 RPS6KB2 CYP7A1 PIK3R4 PIK3R3 HRAS MAP4K3 MAP4K4 MAP4K1 MAP4K2 THRB THRA PCK1 SLC2A4 RPTOR FBP1 RPS6KA6 MLST8 SLC16A2 FOXO3 PIK3CD PIK3C2G SHC3 PIK3CB G6PC1 PIK3C2A PIK3CG TSC1 MAP2K5 SLCO1C1 PIK3CA PIK3C3 LPL CILIARY LANDSCAPE%WIKIPATHWAYS_20260910%WP4352%HOMO SAPIENS Ciliary landscape MCM2 CD2BP2 BBS9 BBS7 CEP97 ECHS1 CEP290 BBS5 ANKS6 PSMD8 NEK8 BBS2 PSMD7 BBS1 TTC8 VIM MCM10 CALM1 SNRPB2 RNGTT LRPPRC RHBDD2 PSMC6 PSMC4 ZYG11B HDAC1 PSMD12 POM121;POM121C STOM EXOSC4 PSMD13 RAC1 CREBBP RAB8A DVL3 AGPAT2 RAB2A EXOC7 TRAF3IP1 SMC4 COX6C ARMC8 IFT88 MYL6 INTU COPS7B COPS7A IQGAP1 IQGAP2 CDR2 AAR2 CTSA EXOC6B BBIP1 AIMP1 EHD3 WNK1 RANBP10 GDI1 APC MYL6B TNKS1BP1 TMED1 CNOT6L EIPR1 RAB3IL1 NME8 EXOC4 EXOC3 EXOC5 MAPRE2 EXOC1 YAP1-1 WDR26 EXOSC7 PGRMC2 EXOSC9 EXOSC2 WHRN UBE2D3;UBE2D2 TIPRL-2 MKLN1 GID4 GID8 YPEL5 DGKE MAEA APMAP LZTFL1 TTC30A;TTC30B LCN2 ERF ARL8B SPATA7 CDH23 UBE2H TFAP2D FUZ CNOT10 LSM4 IFT20 COPS4 COPS3 COPS5 CNOT1 COPS2 COPS8 TFAP2E;TFAP2B TTC26 ZMYND19 MCM8 RAB14 MCM9 RPGR IFT52 IFT57 IQCB1 RBM14 ARFGAP3 RABEP2 SSNA1 EFHC2 CCDC40 VPS4A USH1C EHBP1 RAB21 RMND5B DNPEP RMND5A DCAF11 LCA5 MFAP1 VAPB CLUAP1 CTNNB1 TFAP2A RB1 TFAP2C UQCC1 CNOT9 MKS1 DOCK5 SNAP29 ARHGDIA NEK7 RALB CTBP2 MSH2 IQGAP3 H3-3A HDAC2 GLB1 ACSL3 NEFL DDX5 PAFAH1B1 COPS6 NFKB1 BBS4 NDUFA9 NUP133 NDUFA5 NEFM CBS;CBSL MCM7 MCM3 NUP88 MCM4 MCM5 MCM6 IFT172 DCAF7 IFT74 AFG3L2 WEE1 HTRA2 GLA CAMK2A XPNPEP3 EXOC8 EXOC2 DYNC2I2 DYNC1H1 EIF5B DYNC1I2 DYNC2I1 DYNLT1 NUDC IFT140 DYNLT2B IFT122 IFT80 HSPB11 DYNC1LI1 IFT22 IFT43 IFT81 RANBP9 IFT27 DYNLRB2 DYNLRB1 IFT46 EXOC6 EFTUD2 TBC1D4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260910%WP1993%HOMO SAPIENS Angiogenesis overview NRP1 MAP3K7 ROBO4 MAP2K4 SHB ROBO1 TIMP4 BAD WAS MAPK14 ATF2 BMX ELK1 PDPK1 PTPN11 MAPK11 PLXND1 DOK2 SEMA4A MMP2 F2 GRB2 DAG1 MMP9 SOS1 CRK SHC1-1 VHL SRC CDC42 PAK1 KDR FGF1 PTK2B IQGAP1 VEGFA NOX4 APC PRKCA GRB14-1 GRB7 SEMA3A MAPK8 PLCG1 PLA2G1B KRAS MAP2K6 NCK1 RAF1 MMP14 NOS3 FGFR1 TIMP2 PIK3CD AKT1 PXN MTOR ANGPT1 FRS2 TEK SLIT2 MAP2K2;MAP2K1 MAPK1 RAC1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5365%HOMO SAPIENS 4p16 3 copy number variation H3-3A MAPK3 PLCG1 SLBP GAB1 NSD2 CLTCL1 TMEM129 FAM53A POLN CKAP5 LETM1 TACC3 C4orf48 CBL BCS1L GRB2 SOS1 FGFR3 ERI1 FGF2 FRS2 UBE2J2 NELFB NELFA NELFCD NELFE PIK3R1 NAT8L MAPK1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260910%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TRAF6 MAP3K7 PDLIM7 MAPK8 CCL5 TRADD TNF HSP90AA1 IFNB1-4 CCL20 IKBKB CHUK IKBKG IRAK1 TRAF1 RELA MAP3K3 NFKBIA NFKB1 NFKB2 MAPK1 CXCL8 MAP3K14 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260910%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R7 PPP1CA PPP1R12A MAPK8 EIF2S1 PPP1CB PPP1CC PPP1R14A PPP1R15B PPP1R13B PPP1R11 PPP1R10 PPP1R8;STX12 PPP1R2-1 PPP1R9A DDIT3 PPP1R16B BCL2 PPP1R14B PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B PPP1R3E PPP1R1C PPP1R12C PPP1R1B PPP1R3D PPP1R12B PPP1R14D ATF6 ATF4 MAP1LC3A MBTPS1 ERN1 PPP1R15A XBP1 EIF2AK1 EIF2AK3 EIF2AK2 HSPA5 PPP1R3A MBTPS2 PPP1R14C FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes APOA4 SORT1 ACSL6 ACSL5 APOC2 SCARB1 PCSK9 LDLRAP1 MYLIP ACSL3 SLC27A1 APOE APOB LDLR ABCA1 FABP2 SOAT1 STAR FABP1 FABP3 FABP4 ACSL1 SLC27A4 LIPA STARD3 VDAC1 OSBPL5 NPC2 SOAT2 APOC1 SLC27A3 LRP1 SLC27A2 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260910%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection MYD88 TRAF6 IRF3 JAK1 STAT1 MAVS TYK2 TRAF3 TMPRSS2 IFNAR2 STAT2 OAS3 TLR9 TLR6 TLR2 TLR7 TLR4 TLR3 OAS1 TREML4 IRF9 ACE2 IFNAR1 IFIH1 EIF2AK2 TBK1 IRF7 IRAK4 IKBKE DDX58 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260910%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2A MEF2B;BORCS8-MEF2B KLF4 MEF2D CAMK2D NKX2-5 MEF2C CCND2 ELK1 SRF ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260910%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling PRKCA EIF4EBP1 MAPK3 LAMC2 LAMC1 PRKCD MAPK14 HRAS GAB1 PTPN11 RHOA IRS1 IRS2 ITGA6 GRB2 LAMA5 LAMA2 SOS1 LAMA1 SHC1-1 LAMA3 SRC LAMB3 LAMB2 LAMB1 AKT1 MTOR PIK3R2 PIK3R1 PTK2 MAPK1 ITGB4 RAC1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP357%HOMO SAPIENS Fatty acid biosynthesis PC HADH ACSL6 ACSL5 ACLY ECHS1 ACSL1 SCD ACAA2 ECH1 ECHDC1 ECHDC2 ECHDC3 DECR1 PECR ACSS2 ACACA ACSL3 MECR ACSL4 ACACB FASN 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5402%HOMO SAPIENS 10q22q23 copy number variation NRG3 ERBB4 IQUB SMC3 CEBPA MAT1A NME5 MAS1 TNFSF11 RSPH9 SMC1A RAD21 RSPH3 AFG3L2 STAG1 SH2D4B ADIRF VEGFA BUB1B LDB3 GHITM SF3B4 FAM25A;FAM25C;FAM25G;FAM25E-1 GRID1 MAD2L2 CDHR1 ADAM10 MMRN2 SH3GL3 DYDC2 RGR BMP2 PDS5B PDS5A SNCG C10orf99 RSPH4A SUSD2 WAPL TSPAN14 RSPH1 LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 GPR15 CCSER2 ZMYND11 GLUD1;GLUD2 ACTN2 BMPR1A ROPN1L OPN4 RSPH6A SIRT4 DNAJB13 PPARG NFKB1 DYDC1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260910%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides DES B4GALT1 SGMS1 B3GNT5 DGAT1 SPTLC1 ASAH1 SGMS2 CERS3 UGT8 CERS5 UGCG KDSR CERS6 CERS4 CERK CERS1 B4GALNT1 SPHK1 A4GALT CERS2 A3GALT2 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3R4 PIK3R3 PARP1 PIK3R6 ATM PIK3R5 SIRT1 IKBKG PARP3 PHLPP1 FOXO1-1 PARP2 RPTOR STK11 TSC2 MAPKAP1 MLST8 PDK1 PIK3CD AKT2 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A MTOR PIK3CG TSC1 PIK3C2B GSK3B PIK3R2 RICTOR PIK3R1 PIK3CA OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260910%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 ITGB3 TNFRSF11A SPP1 GPR68 MAPK8 PDGFB IFNB1-4 IFNAR1 TRPV5 SLC9A1 TNFSF11 ACP5 TNFRSF11B AIMP2 CTSK SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260910%WP1455%HOMO SAPIENS Serotonin transporter activity ITGB3 STX1A IL1B SLC6A4 MAOA NOS1 IL1R1 TPH2 SCAMP2 TGFB1I1 PPP2CB;PPP2CA NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2064%HOMO SAPIENS Neural crest differentiation DLL1 DLL3 DLL4 TFAP2A CTNNB1 MYC ASCL1 FGF2 MBP SOX9 PAX3 AXIN2 SOX5 HOXA1 CTBP2 OLIG1 OLIG2 SOX10 HDAC6 BMP4 TCF4 HDAC2 LHX1 HDAC11 MSX2 MIA HOXB1 PHOX2B GJB1 LHX2 LHX5 CDH1 DMBX1 ZIC1 FOXD3 OLIG3 FZD3 DCT WNT3A PRTG GBX2 GSK3B HDAC1 NFKB1 NFKB2 CDH7 HDAC3 TLX2 PAX7 RHOB HAND1 CDH6 CDH2 DLX5 SNAI1 SNAI2 NEUROG1 COL11A2 MITF DVL1 MSX1 DVL2 DVL3 GFAP FGF19 BMP7 HDAC4 HDAC5 RBPJ MYB AXIN1 HDAC8 HDAC9 HDAC7 FGF8 HES1 HES5 ISL1 TCF7L1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 WNT1 SMAD1 ID1 TBX6 ETS1 FGFR3 FGFR2 FGFR1 TFAP2E;TFAP2B COL2A1 HDAC10 HEY2 MPZ ITGB1 WNT8A PMP22 FERROPTOSIS%WIKIPATHWAYS_20260910%WP4313%HOMO SAPIENS Ferroptosis NCOA4 ACSL6 ACSL5 TXNRD1 CBS;CBSL SAT1 PCBP2 SLC7A11 STEAP3 CP SLC39A14 HMOX1 VDAC3 CTH TP53 TFRC SLC3A2 SLC40A1 COQ2 MAP1LC3B2;MAP1LC3B-1 SLC38A1 ACSL4 NOX4 ATG7 ATG5 NOX1 ALOX15 GCH1 SLC1A5 MAP1LC3C FTL-1 BACH1 SLC11A2 TF FDFT1 GPX4 GSS ACSL3 GCLC GCLM ACSL1 POR CISD1 SAT2 AIFM2 VDAC2-1 CHMP6 CHMP5 IREB2 DPP4 FTMT PCBP1 MAP1LC3A CYBB HMGCR PHKG2 PRNP HSPB1 LPCAT3 FTH1 SLC39A8 NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP268%HOMO SAPIENS Notch signaling DLL1 PSEN1 DLL3 DLL4 HDAC2 NOTCH2 NOTCH3 NOTCH1 CREBBP NCOR2 NOTCH4 KAT2A NUMB NUMBL JAG2 JAG1 PTCRA DTX3L DVL1 DVL2 DVL3 KAT2B MAML1 APH1A RBPJ NCSTN DTX1 APH1B RBPJL ADAM17 DTX2 RFNG HDAC1 DTX3 HES1 LFNG INPP5K HES5 KCNJ5 CTBP2 CTBP1 PSEN2 MFNG MAML3 DTX4 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260910%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC CCN1 PRKAA1 RHOB STK3 SAV1 YAP1-1 TEAD1 CCN2 TEAD3 MOB1A;MOB1B TEAD4 LATS2 RHOA LATS1 RHOC PRKAA2 TEAD2 PRKAG1 PRKAG2 PRKAG3 RHO PRKAB2 PRKAB1 HMGCR STK4 RHOD 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome OGDHL EIF4ENIF1 FAM170B VSTM4 MEN1 C10orf71 BAZ1B RGMB WDFY4 SMARCC2 PARG LRRC18 MYO1C ERCC8 ARHGAP22 ERCC6 ATF2 HSF1 ELK1 HSF4 DRGX DDX21 KDM4D C10orf53 SMARCA5 DEK SMARCB1 TMEM273 UVSSA CLOCK DLD GDF5 JUND DLST ITCH SLC18A3 NLRP3 ARNTL BMP2 NEO1 MAPK8 MYBBP1A SF3B1 SIRT1 SMAD1 CUL5 ELOA BCL2 SMAD9 CDH1 ERCC5;BIVM-ERCC5 SMAD5 BMPR1B BMPR1A NOG SIRT6 PCNA CHAT RIF1 FRMPD2 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260910%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA TALDO1 RPE;RPEL1 G6PD TKT PGLS PGD T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260910%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 JAK2 MAPK3 CD3G IL12B CD3E IKBKB PDPK1 TYK2 IKBKG CHUK CD247 CDKN1A FOS RHEB CD3D IRF2BPL PTPRC GRAP2 RELA GRB2 CCL28 IL18R1 SOS1 BCL2L1 NFKBIA CARD11 BCL10 MALT1 CCND1 IL2 IL4 IFNG LCP2 IL12A LAT PTEN TNF IFNB1-4 TP53 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 HLA-DRA RICTOR CCL19 CD28 IL17A MYD88 DEPTOR PRKCQ RASGRP1 PPP3CC PLCG1 BAX HRAS ICOS LTA IL23R JUN STAT4 RAF1 LCK IL12RB1 RPTOR IL12RB2 IFNAR2 NFATC1 IL23A TSC2 MLST8 FYN FOXO3 PIK3CD CD86 AKT1 MTOR CD80 TSC1 IFNAR1 CTLA4 GSK3B CDKN2A PIK3R1 ZAP70 ITPR1 MAP2K2;MAP2K1 NFKB1 MAPK1 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260910%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NLGN1 NLGN3 GRIN1 GRIA1 GRIA3 GRIA4 NLGN2 GRIA2 GRIN3B NLGN4X;NLGN4Y GRIN2A GRIN3A NRXN1;NRXN3;NRXN2 GRIN2C GRIN2B DLG4 GRIN2D PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260910%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3R3 PIK3CD PIK3R6 PIK3C2G PIK3R5 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R2 PIK3R1 PIK3CA TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260910%WP1471%HOMO SAPIENS Target of rapamycin signaling PRKCA EIF4EBP1 PRKAA1 IDI1 RHEB RPS6KB1 RRAGC PRKAA2 PRR5 PRKAG1 PRR5L PRKAG2 DDIT4L RRAGA PRKAG3 RRAGB RRAGD ULK3 CDC42 PRKAB2 RPTOR PRKAB1 TSC2 MAPKAP1 MLST8 ULK2 ULK1 AKT1 MTOR HMGCR TSC1 FKBP1A RICTOR AKT1S1 DDIT4 RAC1 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260910%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM TRAF6 UPF1 ACTL6A ATF2 HSF1 SMC3 MRE11 BRCA1 CASP9 CHEK2 CASP3 CHEK1 MCPH1 NBN APAF1 SMC1A CDC25C FANCD2 BRCA2 DCLRE1C TP53 MDM2-2 BLM ABL1 E2F1 BAK1 BID RAD52 RAD50 RAD51 CDK5 RNF8 PRKDC STK3 RAD17 YAP1-1 BAX PARP1 ATM ATR MDC1 RAD9A TP53BP1 LATS1 EXO1 TERF2 TRIM28 TP73 PCNA CDKN2A RASSF1 NABP2 RIF1 KAT5 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260910%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection MAP3K7 MAPK9 MAPK3 PDCD1 CSF2 IKBKB IKBKG CHUK ITK FOS CD3D RRAS CBL PTPRC GRAP2 GRB2 DAG1 SOS1 NFKBIA IL10 CARD11 BCL10 PTPN6 MALT1 CHP1 PAK1 AHSA1 IL2 IL4 IFNG CD40LG LCP2 LAT TNF IL5 CD4 MAP3K8 CD28 CALM1 MAP3K14 PRKCQ CDK4 PLCG1 ICOS NFATC2 MAP2K7 DLG1 JUN NCK1 RAF1 LCK CD8A PDK1 FYN AKT1 CTLA4 GSK3B PIK3CA ZAP70 MAP2K2;MAP2K1 NFKB1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260910%WP1772%HOMO SAPIENS Apoptosis modulation and signaling TRAF6 MAPK3 BAD CASP5;CASP4 IKBKB BCL2A1 FOS BBC3 CASP9 PIDD1 BCL2L1 AIFM1 NFKBIA CASP3 HRK APAF1 PEA15 BOK BIRC7 SEPTIN4-1 BIRC2 PTRH2 BIRC3 MADD ENDOG TNFRSF25 BLK DIABLO-1 BCL2L10 CFLAR BAG3 BMF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BNIP3 TP53 HTRA2 BCL2L2 CYCS-1 IL1R2 IRAK1 CASP7 CASP1 PMAIP1 CASP6 CASP2 BAK1 BID MCL1 TOLLIP MAP3K14 MYD88 PRKD1 PTPN13 MAPK8 CASP8 FAS BAX TRADD XIAP RIPK1 FADD CRADD TNFRSF1A JUN TRAF3 BCL2 DFFB DFFA CAPNS1 TNFRSF1B BIRC5 IL1R1 AIFM2 BCL2L11 MAP3K5 HSPA1A;HSPA1B FASLG DAXX NAIP BIK CDKN2A CASP10 TNFSF10 NFKB1 SMIM40 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260910%WP4255%HOMO SAPIENS Non small cell lung cancer MAPK3 RXRA PLCG2 BAD STAT3 PDPK1 RET JAK3 RB1 CDKN1A HGF GRB2 CASP9 SOS1 STAT5A STAT5B EGF CASP3 EML4 CCND1 TGFA ERBB2 RASSF5 DDB2 POLK TP53 FHIT CYCS-1 SOS2 EGFR E2F1 E2F2 E2F3 PRKCG BAK1 BID GADD45B GADD45A PRKCB GADD45G PRKCA CDK6 CDK4 NRAS PLCG1 CASP8 BAX HRAS KRAS ALK RXRB RAF1 MET RXRG ARAF CRABP2 CRABP1 KIF5C FOXO3 PIK3CD KIF5B AKT2 KIF5A AKT3 PIK3CB AKT1 RARB CDKN2A BRAF PIK3CA RASSF1 STK4 MAP2K2;MAP2K1 MAPK1 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260910%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb NDUFA9 MAPK3 POLR3E PRKAA1 NDUFA4 MAPK14 MAPK12 MAPK13 CDH18 MAPK11 UQCRB UQCR11 UQCR10 RPS6KB1 PRKAA2 UQCRQ PRKAG1 UQCRC1 PRKAG2 UQCRFS1 CYC1 PRKAG3 UQCRC2 PRKAB2 COX7C PRKAB1 COX5A RAB5IF TRPM7 PDZD9 SDR42E2 VWA3A CDR2 MOSMO-1 CALM1 CALM2 CDK2 CDK1 TRAP1 RPS6KA1 EEF2K EEF2 CALM3;CALM1 RPTOR NDUFS8 NDUFS3 MLST8 MTOR MAP2K2;MAP2K1 MAPK1 NDUFV1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260910%WP186%HOMO SAPIENS Homologous recombination RAD52 RAD50 NBN RAD51 RAD54B POLD3 POLD4 BRCA2 ATM POLD1 POLD2 MRE11 RPA1 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling TRAF6 IL1B CSF2 ICAM1 BCL2A1 IKBKB MMP1 CHUK TNFRSF1A IL6 MMP2 RELA PTGS2-2 MMP9 MMP3 CXCL8 CCND1 IL2 VCAM1 SELE IL1A BIRC5 BIRC2 BIRC3 CD40LG CFLAR TNF BCL2L2 REL RELB VEGFA CXCL2;CXCL3;CXCL1-1 NFKB1 NFKB2 EGLN2 SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260910%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL10 IL6R TRAF6 IRF3 JAK1 CSF2 STAT1 MAVS NUP98 EP300 TFAP2A IL6 TRAF2 CCL3L1;CCL3L3;CCL3;CCL18 IL10 CXCL8 RAE1 CCL4L2;CCL4L1;CCL4 TP53I3 PF4;PF4V1-1 LARP1-1 TLR7 TNF CXCL13 IFNB1-4 CXCL9 TANK CXCL17 IFIT2 AP1G1 IRF7 BSG CXCL2;CXCL3;CXCL1-1 LAG3 CD160 PPBP CXCL11 HDAC2 CASP8 HAVCR2 TRADD RIPK1 FADD TRAF5 CXCL12 TRAF3 IFITM3;IFITM2;IFITM1 SMAD2;SMAD3 IFNAR2 STAT2 CCL5 MX1-1 ACE2 CCL13;CCL2 IFNAR1 TBK1 CXCR2 DHX58 TGFB1 TRIM25 CXCL5;CXCL6 NFKB1 DDX58 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis SRD5A2 AKR1D1 HSD11B1 HSD11B2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP21A2 CYP11B1;CYP11B2 SRD5A1 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260910%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress MAP2K4 MAPK14 ATF2 ICAM1 IKBKB KEAP1 IKBKG CDKN1A FOS IL6 RHEB BCL2L1 CXCL8 CHEK1 NOS2 SOD2 IL1A HMOX1 CREB1 RPS6KA5 PTEN TNF CCNE1 TP53 NFE2L2 MDM2-2 CAT IPCEF1 PIP-1 NOX1 GSX1 CDK2 MAPK8 PINK1 ATR SIRT1 CUL3 PTGS2-2 MAP2K3 FOXO1-1 BCL2 NQO1 NRF1 AKT1 MAP3K5 MTOR TSC1 PIK3CA NFKB1 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260910%WP5598%HOMO SAPIENS Sodium channel in epilepsy JAK2 PTPRN PSEN1 RACK1 SCNM1;TNFAIP8L2-SCNM1 SCN11A PDCD10 FGF13 SCN7A FGF12 SCN3B SCN3A SCN1B CAMK2A MAPK8IP2 BACE1 NFASC SCN4A SCN4B SCN2B RNF121 NEDD4 PRRT2 SCN9A SCN1A SCN10A SCN2A SCN8A FYN TNF WEE1 AKT1 GSK3B NEDD4L SCN5A FGF14 CALM1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation BMP4 BMP2 MAPK3 STAT1 MAPK14 MAPK12 MAPK13 NPR2 MAPK11 PTH1R CDKN1A SNAI1 THRA PPP2CB;PPP2CA RAF1 FGF18 FGFR3 CNP IHH SOX9 RBL1 FGF9 MAP2K2;MAP2K1 MAPK1 PTHLH ATG5 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260910%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD CD38 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260910%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP PORCN LRP6 LRP5 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260910%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 CDH1 MYC E2F1 IL6ST MMP9 BAX SOCS3 STAT3 CHI3L1 TP53 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC3 HDAC2 AHCY TYMS MTR-1 ATF2 SLC19A1 DHFR2;DHFR ADH1C;ADH1B;ADH1A ELP3 ALDH2 ALDH1A1 MAT1A ACSS2 MTHFR KAT2B HDAC4 HDAC5 ALDH1A3 HDAC8 HDAC9 HDAC10 HDAC7 HDAC1 ALDH1A2 CYP2E1 EHMT2 HAT1 HDAC6 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5366%HOMO SAPIENS NF1 copy number variation syndrome H4C6 ARF6 MAPK3 JARID2 NGFR MAP3K2 MAVS TUBB4A;TUBB;TUBB8B;TUBB8 RTN4R SOS1 EGF EIF3A ROCK2 CFL1 EXOC7 CCNE2 PRMT5 CCNE1 IFNB1-4 CCNA2-1 EGFR OMG MCL1 HOXA1 SUPT5H MYT1 DNMT1 RAD51 EXOC4 PER1 EXOC3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EXOC5 EXOC1 ATR NF1 RAD9A EXOC8 WDR48 RHOA NGF HOXA9 EXOC2 POLRMT EVL ATAD5-1 SDC2 RNF135 INPP5A MAP3K1 RFC5 RBBP7 RFC3 E2F6 RFC4 RAB11FIP4 BCL2 RFC2 TEFM SUZ12 RAF1 UTP6 COPRS EVI2A CRLF3 EVI2B METAP2 LIMK1 EED SYN1 EZH1 EXOC6 USP1 PCNA H4-16 ADAP2 RAB11A CRY1 MAPK1 H4C1 DDX58 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260910%WP1422%HOMO SAPIENS Sphingolipid pathway PPP1CA SGMS1 ASAH1 CERS3 CERS5 CERS6 CERK GAL3ST1 SPHK2 SPHK1 PPP2CB;PPP2CA ASAH2 SGPL1 SPTLC3 CERT1 SGPP2 ACER1 SERINC1 PLPP1 SPTLC1 GBA SGMS2 GBA2 UGT8 UGCG KDSR CERS4 CERS2 B4GALT6 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260910%WP3972%HOMO SAPIENS PDGFR beta pathway JAK2 PRKCA RASA1 MAPK3 JAK1 MAP2K4 MAPK8 PLCG1 STAT1 HRAS STAT3 ELK1 FOS GRB2 JUN MAP3K1 SOS1 STAT5A STAT5B SHC1-1 RAF1 PDGFRB STAT6 EIF2AK2 PIK3R1 PIK3CA MAP2K2;MAP2K1 PRKCB SRF STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260910%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 STAR CYP19A1 CYP17A1 HSD3B1;HSD3B2 CYP11A1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5406%HOMO SAPIENS 13q12 12 copy number variation DMD LINGO1 MAG MAPK9 FLNC RTN4 MAPK8 RHOA RTN4R SGCD TRAF5 SGCA MIPEP SGCB ADIPOQ TRAF1 DAG1 TRAF2 SGCG TRAF3 CDC42 SACS DTNA SSPN SNTB1 C1QTNF9B;C1QTNF9 ATXN1 SNTA1 TNFRSF19 SPATA13 RAC1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260910%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome MS4A1 ITGB2 CD63 IGSF8 PHF21A CD19 ALX4 TP53I11 PEX16 SYT13 HBEGF SDCBP REST B4GAT1 TSPAN18 IZUMO1-1 ITGA4 ITGA3 CLOCK ITGA6 LGALS3BP TIMP1 CHST6 EXT1 EXT2 SHH TP53 CD4 LEF1 HLA-DRA HLA-DMB ARNTL CHST1 B4GALT4 VANGL1 NRXN1;NRXN3;NRXN2 HLA-DMA CD151 NDST1 GLI3 CD82 SPPL2C ACCS C11orf96 C11orf94 LARGE2 ALKBH3 CD53 SLC35C1 MAPK8IP1 ITGB1 SLC25A17 B3GNT7 CRY2 PEX3 PRDM11-1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260910%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNB1 GNG2 CDK5 GNAI1 PPP1CA PRKACA-1 PPP1R1B DRD2 DRD3 DRD4 CHRNA3 KCNK9 CHRNA5 TH CHRNA4 CHRNA6 KCNK3 SLC18A2 CHRNB2 DDC ADCY2 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP69%HOMO SAPIENS T cell receptor signaling TRAF6 SKAP1 CBLB MAP3K7 MAPK9 MAPK3 PRKCD WAS MAPK14 ATF2 CD3G VAV3 CD3E IKBKB PDPK1 PTPN11 IKBKG CHUK VAV1 CD247 ITK GAB2 PSTPIP1 FOS DBNL CD3D FYB1 CBL GRAP2 RELA GRB2 SOS1 CRK NFKBIA SHC1-1 CARD11 BCL10 MALT1 CDC42 PAK1 CREB1 LCP2 LAT CD4 PTK2B MAP3K8 CD28 MAP3K14 PRKCQ MAPK8 PLCG1 HRAS ICOS NFATC2 MAP4K1 JUN NCK1 CRKL RAF1 LCK CD8A NFATC1 RIPK2 FYN AKT1 REL PIK3R2 PIK3R1 ZAP70 ITPR1 SH2B3 MAP2K2;MAP2K1 NFKB1 MAPK1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260910%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction TPO INHBB CCL27 CCL26 CNTFR IL27RA IL36A IL36B TNFSF14 XCL1;XCL2 GDF2 IL36G GDF1 GDF6 GDF7 EPO IL1F10 IL22RA1 CD27 IL20 TNFRSF13B PF4;PF4V1-1 IL26 IL27 CNTF TNFRSF13C CD40LG BMP15-1 IL17RB CCL14 CXCR6 RELT TNF CCL8 GDF10 CXCL13 CCL25 GDF11 CCL24 IL31 IL1RAP IL37 CD70 IL34 CXCR5 BMP8B ACKR4 CLCF1 NFIC LIF CCL19 AMHR2 CXCL2;CXCL3;CXCL1-1 MPL TNFRSF8 CCL21 IL13RA2 EDAR CXCL11 TNFRSF17 IL36RN TNFRSF14 BMP4 INHBC INHBE TNFRSF18 IL9R IL17RC IL1RL2 ACVR1C LTBR TNFRSF4 IL11RA TNFRSF1A CCL22 TNFRSF9 TNFSF9 TGFBR1-1 IL13RA1 TNFRSF1B ANP32B TSLP MSTN TNFRSF12A ACVR2A IL10RA IL6R NGFR TNFSF13B IL6 TNFSF11 LTB IL6ST IFNLR1 IFNL2;IFNL3;IFNL1 IL10 CCL11 CXCL8 IL18 CSF3R IL2 IL4 IL1A IFNG CSF1R IL7R GHR BMP5 BMP3 BMP6 NGF TNFSF4 ACVRL1 IL21 IL3RA IL22 CXCR4 IL23R CXCL12 TNFRSF21 CD40 IL18RAP IL25 IL21R IL12RB1 IL12RB2 IFNGR1 BMPR1B IL23A BMPR1A BMPR2 EPOR IL17RA FASLG IL1RL1 IFNK CCR9 IL20RA IL20RB IL19 GDF5 CCR8 EDA CCR6 EDA2R CX3CR1 CSF2RA CCL1 IL11 IL33 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CCL20 IFNB1-4 IL15 IL10RB IL3 IL7 ACVR1B GDF9 INHA FAS LTA LEPR CX3CL1 CCL23;CCL15 TNFRSF11B TNFRSF11A IFNAR2 IL1R1 IFNGR2 CCL5 ACVR1 IL31RA CCL13;CCL2 IFNAR1 PRL IL2RG IL17D TGFB2 GDF3 IL4R PRLR IL17C TGFB1 TGFB3 IL17B TGFBR2 CXCL10 IL2RA IL2RB CSF3 CSF2 LEP CCR3 CCR2 AMH IL13 CCL28 ACVR2B IL18R1 IL5RA CSF2RB CCL3L1;CCL3L3;CCL3;CCL18 CCL4L2;CCL4L1;CCL4 IL9 TNFRSF25 BMP7 GDF15 IL5 CXCL14 CXCL9 CSF1 IL1R2 CXCL17 IL17F PPBP IL17A TNFSF15 IL24 BMP10 CCR10 CCR1 NODAL XCR1 IL1RN ACKR3-2 CCR7 CCR5 CCR4 TNFRSF19 LIFR INHBA CXCR1 CXCR2 TNFSF10 CXCL5;CXCL6 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260910%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure STAR HSD3B1;HSD3B2 CYP11A1 BAX PRDX2 CASP3 MAPK10 PARP2 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TCF4 MEF2B;BORCS8-MEF2B CD79B CD79A LOC102723996;ICOSLG SPIB SLAMF1 POU2AF1 SPI1 STAT3 TLR10 EZH2 CDKN1A CDKN1B IL6 POU2F2 CCND3 LYN CCND2 SYK BCL2L1 CD40 IL21R MYC ID3 TLR1 TNFRSF13C TLR9 TLR5 TLR8 TLR6 TLR2 TLR7 TLR4 TLR3 BCL6 IRF4 IRF8 BCR E2F1 STAT6 CDKN2A IL4R MEF2C NFKB1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260910%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA1 CHAT PEMT CHKA ACHE PCYT1A GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260910%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis SLC2A1 GCG GLP1R PCSK1 INS;INS-IGF2 PCSK2 VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260910%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling PRDX6 ACTG1 GJA1 MYO6 PRKAA2 EIF3H EIF3F CACNA2D1 EIF3D FN1 CCND1 SELE CNP CLTC RPS6KA5 AP2A1 MKNK1 EPRS1 BMP2 NAPA MAPK8 ARF4-1 WASF1-1 PLA2G4A ARPC5L AP2S1 RPL7 FADD LUC7L IER5 SND1 TPM3 EWSR1 BIN1 GPX1 RPL27 PRKD2 RPL26 FLII NCF2 ABCF2-H2BE1;ABCF2 GIGYF2 PRRC2C TRIP4 NR4A2 LARP7 NR4A1 RPL5-1 GIPC1 MMP10 FARSB KCNC3 EEA1 PBK MMP14 TBCA MOV10 RPLP2 CGNL1 NCL-1 SSR4 SSR3 TAL1 KANK1 SLC7A1 APOLD1 FGD5 BRD4 AKT1 CTNND1 SH3BGRL3 PLOD3 MTOR RPL10A TMSB10 SEMA6D ARMCX1 RAB37 FSCN1 GSK3B DSC1 HDAC1 LRRC59 PIK3R2 STIP1 PIK3R1 HLX TXNDC5 QKI PTMA RCAN1 PNP-1 MAP2K2;MAP2K1 TFCP2 SYNJ1 EPHA2 MAPK1 RCAN2 RAC1 TPP1 NRARP CAPZB RHOJ ADAMTS1 ARF6 ADAMTS9 MAPK3 DKK1 ACP1 PRKG1 MAP2K4 SARS1 CREBBP RPL13A-1 STAT1 SLC25A11 PBXIP1 MYO1C PRKCD DNAJB4 STAT3 SLC25A25 CDC42BPB GAB1 PTPN11 PTPN14 TPCN2 PTPN9 P4HB TRAF3IP2 RPL18A UBAP2L CHAC1 RPS6KB1 TMEM170A TNXB INPP4B GRB2 KATNAL2 ZNF555;ZNF57;ZNF556 PFN1 BCL2L1 ATP6V0D1 FXR2 SHC1-1 SHC2 ATP6V1E1 DHX36 MICAL2 CALU CXCL8 DHX29 NRP2 FAF1 CCDC124 HERPUD1 CLIC1 FJX1 NEXN HMGB1-1 CRIP2 GPC1 EPS15 PRKRA COPG1 FHOD1 TMOD1 TMOD3 PSMD11 HTRA1 SCUBE2 ZC3H15 DNAJA1-1 GRSF1 C15orf39 RND1 LRRFIP2 ARHGEF15 SHROOM2 PRKCI EPN1 RCN1 USP10 PRKCB FAM120A PRKCE PDE4DIP PRKCA FMNL3 ALDOA EZR PRKD1 NOTCH4 PRKCZ HSP90AA1 TEAD4 CCT7 JAG1 TAOK2 NFATC1 NOS3 FOXO3 HGS SET-1 PIK3CA FLT1 PGF TXN SPIRE1 DLL4 MAPK9 PLA2G5 MAPK14 MAPK12 CTNNB1 TRPC3 TRPC1 EGR1 FOXO4 EGR3 CREB1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MDM2-2 CYCS-1 ABL1 PPP1CA FAS FBXW11 FOXO1-1 ACACA FYN PRDX2 ACOT9 CCL13;CCL2 STAT6 OCLN-1 ARNT NFKB1 AFDN NR4A3 CCN1 PLAU CSRP1 CCN2 NUMB IDH2 ARRB2 TKT MMP2 TXNIP CAMKK2 NCF1 HDAC4 HDAC5 HDAC9 HDAC7 VEGFA MEF2C MYL2 ADAM10 BMP10 HRAS TFAM-1 PTGS2-2 ACKR3-2 NCK1 ETS1 ELOA MYH9 PTPRZ1 ENG NAP1L1 MAPKAPK5 LDHA GAPDH-1 PRKAA1 PGK1 CCRL2 ATF2 ELK1 CBL RELA PLAUR F3 ADAM9 SRPK1 NFKBIA PTPN6 PSMD4 KDR SRP54 LMAN1 ATF6 ATF4 EIF2AK3 RICTOR NOX4 TUBA1C FLNB SIAH2 PPM1G PPP3CA PLCB3 DUSP5 RBM39 MAP2K7 EIF4E MAP2K6 MAP2K3 JUN BCL2 RAF1 SMARCA2 EPHB2 MAP3K5 CYBB ERN1 CALR-1 FHL2 AMOT RACK1 CDH5 HBEGF TUBB4A;TUBB;TUBB8B;TUBB8 ANXA1 RHOC CFL1 MAPKAP1 SLC8A1 ITCH PTK2B IQGAP1 IGFBP3 ADRB2 KL NFATC2 STAM VPS39 BIRC5 PTPRJ CAPN2 RPS11 VCL PXN RAP1B RAP1A CAV1 PTK2 ITGB1 ITGB5 ITGB3 SDF2L1 SHB ITGAV SDCBP HYOU1 BMX PDPK1 ELOC-1 VAV2 RAPGEF1 ERG CRK ROCK1 ROCK2 SRC CDC42 PAK1 CSK PAK2 LDB2 BCAR1 YWHAE DECR1 SRF MMRN2 MAPKAPK2 MYH11 ACACB PPP2CB;PPP2CA CTNNA1 PABPC1;PABPC3 EIF4G2 DNAJB9 EIF2A RPS6 INPP5K PDIA6 OCRL CSRP2 PTPN1 ICAM1 RAB5A FGB FGA ASCC3 FGG GRB10 HBD;HBB DOK1 SOD2 TNFRSF25 ALB FUT1 GATA2 BSG EPB41 PLCG1 EIF4G1 RHOA GLUD1;GLUD2 S1PR1 P4HA2 LIMK1 MLST8 IGFBP7 FRS2 HSPA1A;HSPA1B HSPB1 NDRG1 DPM1 RAB4A AKT1S1 RAB11A PGD UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260910%WP5158%HOMO SAPIENS Urotensin II mediated signaling JAK2 IRF3 MAPK9 MAPK3 CREBBP COL1A1 MAPK14 ICAM1 STAT3 IKBKB UTS2R PTPN11 EP300 CTNNB1 CHUK IL6 MMP2 RELA CASP9 MMP9 CASP3 FN1 ABCA1 COL3A1 VCAM1 HMOX1 NCF1 NCF4 PTEN TNF CCNE1 CYBA HDAC5 ACTA2 EGFR ESPL1 GSK3A NOX4 TRPC4 HSPA2 IL1B CDK2 MAPK8 CDK1 CAMK2A ALOX5 BAX NPPA RHOA NCF2 DDIT3 BCL2 SMAD2;SMAD3 NPPB PRKACA-1 AIFM2 COL2A1 AKT1 CYBB AGTR1 PCNA GSK3B FSCN1 TGFB1 NFKB1 MAPK1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260910%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome APOC2 MECP2 TET1 REST CSRP1 SMC3 DLX5 SGK1-1 IGF1R FUS DHX9 OPRK1 SP1 CREB1 CNP YBX1 PTEN FGF2 CEBPD NCOR1 MBP FGF3 FGF4 FGF5 FKBP5 HNRNPH1 E2F1 CTCF MEF2C IGF1 GRID1 MYT1 MAG PSIP1 RBFOX1 GRIA1 GPRIN1 GRIA3 GAD1 SST TET3 GRIA4 ARHGEF26 DLX6 IGF2 TET2 CAMK2A NREP FUT8 MPP1 PRPF38A EZH2 POU4F1 UBE3A HNRNPF SP3 NF1 POU3F2 BDNF FOXG1 GRIN1 TAP1 TAF1 AKT1 MTOR BCL6 SIN3A HDAC1 GAMT RPS6 TARDBP GABRR2 CDON MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260910%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A USP1 ID1 ID2-1 ARCN1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260910%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia DKK1 WIF1 PPARD WNT1 CTNNB1 RUNX1T1 JUP ZBTB16 FZD6 CCND1 MYC FLT3 LRP6 SALL4 AKT1 AXIN2 LEF1 RARA GSK3B LRP5 CSNK1A1 PYGO1 PML BCL9 APC MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway IDI1 MVK IDI2 ACAT1 ACAT2 HMGCL MVD HMGCR HMGCS1-1 PMVK FDFT1 FDPS GGPS1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260910%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ3 FAAH CACNA1H PTGS1 PTGS2-2 TRPA1 TRPV1 KCNQ2 HTR1A SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260910%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis VAMP2 NAPA STXBP1 CACNA1B CACNA1A SNAP25 RAB3A CPLX1 RPH3A RIMS1 STXBP5 STXBP6 SYT1 NSF UNC13A SYP GDI1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260910%WP322%HOMO SAPIENS Osteoblast signaling ITGB3 FGF23 IBSP COL1A1 PDGFRA ITGAV PDGFB PDGFRB PTH1R SLC17A2 TNFSF11 PTH TNFRSF11B TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260910%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals PRKCA GSTA3;GSTA5;GSTA1;GSTA2 GCLM NQO1 HMOX1 MAPK8 MAF EPHB2 NFE2L2 KEAP1 SLC7A11 PIK3CA CEBPB GCLC AIMP2 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260910%WP5028%HOMO SAPIENS Glycine metabolism including IMDs ISCU SHMT1 AMT LIPT2 LIPT1 PNPO GLDC DLD GLRX5 GCSH-3 IBA57 HSCB LIAS NFU1 BOLA3 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260910%WP399%HOMO SAPIENS Wnt signaling and pluripotency MAPK9 WNT11 WNT7B MAPK10 EP300 PPARD CTNNB1 CCND3 CCND2 FOSL1 CCND1 MYC TP53 LRRK2 AXIN2 CTBP2 CTBP1 NKD1 NKD2 SOX2 JUN ESRRB MMP7 PPP2CB;PPP2CA FZD1 FOXD3 FZD3 PAFAH1B1 WNT3A WNT5A WNT7A WNT3 LRP6 CTNND1 GSK3B NFYA-1 PPP2R1B PPP2R1A NLK PPP2R2A;PPP2R2D MAP3K7 MAP2K4 CREBBP PRKCD PLAU TPTEP2-CSNK1E;CSNK1E TCF7 LDLR DVL1 DVL2 DVL3 FZD10 AXIN1 LEF1 PRKCG PRKCI TCF7L2 PRKCH TCF7L1 WNT5B PRKCB PRKCE APC PRKCA POU5F1;POU5F1B PRKCQ PRKD1 CD44 NANOG;NANOGP8 PRKCZ WNT6 WNT1 WNT2 RHOA RACGAP1 WNT4 WNT10B WNT10A FZD2 FZD5 FZD4 FZD7 FZD6 FZD9 FBXW2 FZD8 PPM1J PPP2R3B PTPA WNT2B PPP2R3A PPP2R2C PPP2R2B ZBTB33 PPP2R5E PPP2R5C WNT9B WNT16 LRP5 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation SMCR8 GAS8 RMND5A GPS1 MIEF2 LDHA RASD1 NT5M PRKAA1 FNIP1 CLUAP1 FNIP2 FBXL13 MYO16 MYO15A DRG2 CCDC65 GPR85 CLOCK RELA APP PRKAG2 ROCK1 MYC PRKAB1 TNFRSF13B ATG13 BIRC2 CREB1 ULK1 CLTC CLTA TNF TP53 BLM ARNTL TOLLIP PARD3 MAP3K14 MYD88 PARD6B IL1B NR1H3 PER1 RNF41 CDK1 BAX WWTR1 FOXA1 SREBF1 PEMT NR1H2 FLII JUN APBB1 FOXA2 RAI1 COPS6 MTOR PRDM1 NFKB1 CRY2 CRY1 ETV5 PPP1R12A ATG101 STAT3 C9orf72 PPP1R14A RAB8A RB1CC1 CARM1 RRAGA IFT172 USP8 IFT74 TRAF3IP1 PTEN TLR4 FHOD1 ARMC8 PRKN IFT88 COPS7A MED9 HES6 PRKCI CLEC16A GRIP1 SHMT1 YAP1-1 WDR26 RHOA CLTB MKLN1 GID4 MAEA TTC30A;TTC30B PCK1 TFE3 CFL2 IFT80 RPTOR FERD3L HSPB11 ALKBH5 MPRIP IFT20 LIMK1 DENR COPS4 MIGA2 COPS3 IFT22 MIGA1 COPS5 DRC3-1 IFT81 MLST8 TOM1L2 COPS2 IFT27 RANBP9 LLGL1 COPS8 IQCA1 BCL2L11 DRC7 TTC26 IFT46 RAB10 ATPAF2-2 PLD6 G6PC1 RAB39B BCL6 HBP1 DRC1 IFT52 GDI2 IFT57 IRF8 WDR41 FLCN EFCAB2 RMI2 ARG2 RMI1 TOP3A ITPK1 TFEB IQCD TCTE1 IQCG DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260910%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR MCM2 SMARCC2 UPF1 DCLRE1A UBE2D3-1 SEM1 UIMC1 TOPBP1 IKBKG HUS1 POLN RECQL EEF1E1 ABRAXAS1 MRE11 BRCC3 PPM1D BRCA1 RECQL5 RBBP8 CLSPN TDP1 RFWD3-2 CLK2 CHEK2 CHEK1 MCPH1 NBN SMC1A CDC25C CDC45 PLK1 SP1 FANCD2 BRCA2 TP53 MDM2-2 E2F1 BARD1 ATRIP MSH2 RPA2 XPA PML BRIP1 RAD52 RAD50 FANCI RAD51 CDK2 RNF8 FANCA PRKDC CDK1 RAD17 PALB2 PARP1 RAD1 ATM ATR MDC1 RAD9A FEN1 TP53BP1 POLB EXO1 SMARCAL1 TRIM28 WRN BCL6 USP1 PCNA XRCC5 RMI1 RPA1 TOP3A FOXM1 CEP164 MLH1 HERC2 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260910%WP3930%HOMO SAPIENS EDA signaling in hair follicle development EDA DKK1 DKK4 WNT3 SOSTDC1 SHH BMP1 LTB GLI1 RELB EDARADD PTCH1 EDAR SLEEP REGULATION%WIKIPATHWAYS_20260910%WP3591%HOMO SAPIENS Sleep regulation NLGN1 HTR2A AHCY PTGDR GHRH GHRL PTGDS HCRTR2 NPY2R HCRTR1 UTS2R ADORA1 FOS DLAT CHRNB2 IL6 CACNA1I SLC29A1 MTNR1B MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 IL18 STAR NPAS2 OXT-1 ADA DRD1 DRD2 DRD3 ADORA2A TH GRIN2A BTBD9 OXTR CST3 NPS CRH FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260910%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma PCGF1 H3-3A MACROH2A2 H2AZ2;H2AZ1 MACROH2A1 H2AJ MAPK3 EED H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EZH2 DUSP6 BCOR H2AB2;H2AB3;H2AB1 BCL6 KDM2B MAPK1 SUZ12 RNF2 VISUAL CYCLE%WIKIPATHWAYS_20260910%WP5534%HOMO SAPIENS Visual cycle LRAT ABCA4 RDH11 RHO RBP3 RDH8 RLBP1 RDH10 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RBP1 OPN1SW RDH5 RPE65 RDH12 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260910%WP334%HOMO SAPIENS GPCRs class B secretin like VIPR1 GHRHR ADCYAP1R1 CALCRL VIPR2 GIPR ADGRE5 GCGR GLP2R SCTR PTH2R CRHR1 CRHR2 ADGRE1 ADGRL2 PTH1R ADGRG2 ADGRL3 CALCR ADGRL1 ADGRL4 GLP1R DOPAMINE METABOLISM%WIKIPATHWAYS_20260910%WP2436%HOMO SAPIENS Dopamine metabolism MAOB TYR COMT PRKACA-1 DDC MAOA NQO1 SOD1 PPP2CB;PPP2CA PRKACB-1 TH BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 BMP2 SMAD5 DKK1 SST LEFTY2;LEFTY1 BCL2L11 CTNNB1 WNT4 DCN SMAD1 SFRP1 FOXO1-1 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260910%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CASP8 BAX MCU TNFRSF1A FFAR3;GPR42 TRPV5 TNFSF11 SMAD4 CASP9 CALCA TGFBR1-1 G3BP1 CASP3 SMAD2;SMAD3 RAF1 APAF1 NOS1 AKT1 MAP3K5 MTOR PPP3R1 PDE1B ACTA2 CRYZL2P-SEC16B;SEC16B RGN PTH BRAF BAK1 PIK3CA TGFB1 MAPK1 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260910%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 TST PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260910%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA SCP2 ACAA1-1 ACOX1 HSD17B4 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome RNF168-1 RNF8 CBX3-1 NIPBL ATM ATR MDC1 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260910%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development PRICKLE1 ANK3 SEMA3A SNAP25 SCN2A ATF6 ATF4 KCNQ2 DNM1L MAPT CSNK2A1;CSNK2A3 EIF2AK3 PRRT2 EIF2A CSNK2A2 SCN5A BRSK1 SPTBN4 CSNK2B BRSK2 DDIT3 ANK2 L1CAM SPTAN1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260910%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins RPL30 TXNRD2 SELENBP1 SEPHS1 PSTK EEFSEC POU2F1 SECISBP2 TRNAU1AP SARS1 SEPSECS TXNRD1 SARS2 SCLY GPX6 SP3 FOS GPX1 GPX4 RELA JUN TXNRD3 CREM SEPHS2 FABP1 SELENOO SELENON SELENOS SP1 SELENOT SELENOK SELENOI CTH SELENOP NFE2L2 DIO1 DIO3 NFKB1 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX15 ALOX5 EPHX2 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260910%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma IL6R MAPK3 JAK1 PODXL MAPK14 STAT3 PTPN11 MMP1 CDKN1A VAV2 IL6 BRCA1 RRM2-1 GRB2 CASP9 SOS1 BCL2L1 CASP3 CXCL8 CCND1 MYC NOS2 BIRC3 COL4A2 TP53 HNF1A LEF1 UCHL1 CASP7 E2F2 VEGFA MAPK8 HIF1A CD44 MYOF CTTN FRZB PTGS2-2 SMAD4 JUN TGFBR1-1 SMAD2;SMAD3 BIRC5 AKT1 FASLG CXCR1 TGFB1 NFKB1 RAC1 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ZP2 MAPK3 ANKRD39 LMAN2L CIAO2A DUSP2 NCAPH PARL RHOA CIAO1 FAM178B ITPRIPL1 TMEM127 COX11 CIAO2B CNNM3 CNNM4 FER1L5 STARD7 SEMA4C ASTL NEURL3 KANSL3 PLXNB2 MMS19 ERBB2 ADRA2B COL2A1 ANKRD23 MAPK1 SNRNP200 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260910%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ RAF1 CHUK TRAF6 IKBKG RRAS MAP2K6 MAP3K1 NFKBIA NFKB1 IKBKB MAPK1 MAP3K14 CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260910%WP2029%HOMO SAPIENS Cell differentiation index TLX3 TLX2 TLX1 LEFTY2;LEFTY1 STAT3 HDAC5 SRF MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260910%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 CCND1 CDH1 MYC TERT NRG3 ALPL ERBB4 TNF AKT1 ZEB2 CLDN4 SFRP1 ITGA6 TGFB1 ITGB1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260910%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways ALDH4A1 PEPD PRODH;LOC102724788 OAT PYCR1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260910%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer DNAJB1 GNAS-1 HDAC7 PRKACA-1 SIK3 SIK2 CRTC2 CREB1 HDAC4 HDAC5 SIK1;SIK1B AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260910%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction ADRB2 MYLK PPP1CB PPP1R14A RHOA GNAQ PLCB1 RYR1 CD38 IL13 ROCK1 CALM1 ROCK2 GDI1 ITPR3 MYL1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260910%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin CXCL10 IL2RB MAPK3 JAK1 MAP2K4 ITGA4 MAPK11 JAK3 IL6 CXCR4 NR3C1 CXCL12 CX3CL1 STAT5A STAT5B CCL3L1;CCL3L3;CCL3;CCL18 PIBF1 IL10 BCL2 CXCL8 CCL4L2;CCL4L1;CCL4 VCAM1 ESR2 IL4 PGR NCR1-1 IFNG MRC1 CCL5 MADCAM1 GAB3 CD69 TNF CCL8 IL15 GATA2 CCL13;CCL2 ANGPT2 IL3 ANGPT1 IL2RG CXCR3 VEGFA HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E MCL1 CXCL11 SELL TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260910%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 SMARCD1 H3-3A SMARCD2 CDK6 SMO SMARCD3 CDK4 SMARCC1 SMARCC2 ACTL6A ARID1B EZH2 RB1 SMARCB1 SMARCE1 GLI1 PTCH1 SUZ12 EED GLI4 ARID1A DPF1 SMARCA4 GLI2 DPF2 ACTL6B DPF3 GLI3 CDKN2A RBBP4 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260910%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 KRAS GRB2 NRAS BRAF SOS1 HRAS PTPN11 NF1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260910%WP696%HOMO SAPIENS Benzo a pyrene metabolism CYP1B1 AKR1A1 CYP1A1 EPHX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260910%WP4628%HOMO SAPIENS Aerobic glycolysis augmented SLC2A1 GPT ALDOA LDHA GAPDH-1 PKM PGK1 ENO1 HK1 PFKM PGAM2 TPI1 GPI SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260910%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TRAF6 NLRX1 TERF2IP TOMM70 MAVS STING1 REN AGT RPS6KA1 IL6 BCS1L TRAF3 IL18 TERF2 ECSIT TNF PHB ACE2 ACE ACAD9 SIRT6 NDUFAF2 NLRP3 NDUFAF1 NFKB1 NOX1 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260910%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP19A1 HSD17B2 HSD17B3 COMT HSD17B10 CYP2C9;CYP2C19 HSD17B7 CYP1A2 HSD17B4 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD17B1 CYP1B1 HSD17B8 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260910%WP5130%HOMO SAPIENS Th17 cell differentiation pathway JAK2 IL6R IL2RA JAK1 RXRA STAT1 MAPK14 CD3G STAT3 CD3E IKBKB TYK2 CD247 FOS IL6 CD3D CLOCK IL27RA STAT5A NFKBIA NR1D1 RUNX1 IL2 IL4 IL27 IFNG LAT GATA3 CD4 AHR ARNTL IL17F NFIL3 IL17A IL1B PRKCQ PPP3CA PER1 MAPK8 HIF1A PLCG1 HSP90AA1 IL21 IL22 IL23R RORC JUN RORA TGFBR1-1 HLA-DMA TBX21 SMAD2;SMAD3 IL21R LCK IFNGR1 NFATC1 FOXP3 IL23A MTOR IRF4 RARA STAT6 IL4R TGFB1 ZAP70 SOCS3 NFKB1 CRY1 MAPK1 GASTRIN SIGNALING%WIKIPATHWAYS_20260910%WP4659%HOMO SAPIENS Gastrin signaling MAPK9 LAMTOR3 MAPK14 ATF2 ELK1 IKBKB CTNNB1 CHUK CDKN1A CDKN1B FOS RELA CRK EGR1 NFKBIA CASP3 ROCK1 SRC CDC42 CCND1 PAK1 MYC BIRC2 BIRC3 CREB1 BCAR1 KIT TCF4 BMP2 MAPK8 YES1 ANXA2 IRS1 PRKD2 SLC9A1 FOXO1-1 JUN MMP7 SLC9A3 RAF1 CDH1 MAP3K11 MEF2D GAST FYN AKT1 MTOR ARHGEF28 CHGA GSK3B HDC RPS6 PIK3R2 PIK3R1 NFKB1 RHOD MAP2K2;MAP2K1 KAT5 MAPK1 RAC1 JAK2 EIF4EBP1 MEF2B;BORCS8-MEF2B MAPK3 KLF4 RHOB SERPINE1 BAD PRKCD STAT3 PTPN11 ARRB1 ARRB2 RPS6KB1 GRB2 SOS1 BCL2L1 SHC1-1 CXCL8 IL2 SP1 HDAC7 EGFR VEGFA MEF2C PRKCH PRKCE PRKCA PRKCQ PRKD1 PLCG1 SERPINB2 CD44 PIK3R3 ELAVL1 HRAS RHOA GNAQ TJP1 KRAS PTGS2-2 CLDN1 JAG1 PRKACA-1 BIRC5 FOXO3 PXN CCKBR CDKN2A PTK2 PIK3CA PPARG ITGB1 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260910%WP106%HOMO SAPIENS Alanine and aspartate metabolism GOT1-1 PC GPT ASL ASPA GAD1 DARS1 GOT2-1 GAD2 ABAT AGXT ASS1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260910%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis APAF1 BAD CASP8 MAPK14 BAX MAPK12 TNF MAPK13 BCL2L11 MAPK11 AKT1 FADD FASLG CASP7 BBC3 CASP9 BID MCL1 BCL2L1 CASP3 BCL2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP707%HOMO SAPIENS DNA damage response RB1 CDKN1A CDKN1B MRE11 HUS1B BRCA1 BBC3 CASP9 PIDD1 CCND3 CCND2 CHEK2 CASP3 SESN1 CHEK1 TLK2 CCND1 TLK1 MYC NBN APAF1 RFC1 SMC1A CDC25C CDC25A DDB2 CREB1 CCNE2 RRM2B FANCD2 CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 MDM2-2 CYCS-1 CCNB3 CCNB2 CCNB1 ABL1 E2F1 PMAIP1 SFN BID ATRIP GADD45B GADD45A RPA2 PML GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 PRKDC CDK1 RAD17 CASP8 FAS BAX RAD1 ATM ATR RAD9A AKT1 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260910%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia MCL1 ZAP70 BCL2 TP53 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260910%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260910%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 CCR5 FLT3 STAT3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260910%WP5606%HOMO SAPIENS Beta globin gene expression regulation DNMT1 HDAC2 TAL1 PPARGC1A CHD3 NR2C2 MYB KLF1 HBG2;HBG1 LDB1 HDAC1 BCL11A LMO2 MTA2 GATA1 NR2C1 HBD;HBB GATAD2B ZBTB7A ZFPM1 KDM1A AXON GUIDANCE%WIKIPATHWAYS_20260910%WP5289%HOMO SAPIENS Axon guidance NRP1 DPYSL5 SEMA6C ILK UNC5D ENAH SEMA7A NTN4 MYL12B NTN3 EFNB1 ROBO1 ABLIM3 PLXNA1 LRIG2 SRGAP2 LRRC4C PDPK1 NTNG2 RRAS SLIT1 SLIT3 TRPC1 ROCK1 FES SRC CDC42 GDF7 CFL1 BOC SHH ARHGEF12 DCC ABL1 RGMA EFNA1 PARD3 RYK-1 L1CAM PRKCA RASA1 CDK5 GNAI1 SEMA3A HRAS PRKCZ WNT4 CXCR4 CXCL12 EPHB1 NCK1 NGEF PTCH1 PARD6A DPYSL2 RAF1 MET FZD3 BMPR1B WNT5A FYN BMPR2 ROBO2 SLIT2 GSK3B ITGB1 RHOD SEMA5B EPHA2 MAPK1 ROBO3 RAC1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260910%WP2889%HOMO SAPIENS Oxytocin signaling PLCD1 GNAQ OXTR CD38 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260910%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid ALOX12B ALOX15 ALOXE3 GPX4 PTGS1 PTGS2-2 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EPHX3 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260910%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 ESD CES2 PON2 CES5A CES1 PON1 LIPA DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260910%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport SLC51A SLC51B AKR1D1 CYP7A1 ABCC3 ABCD3 ACOX2 ABCB4 ABCC4 SLC10A1 ABCC2 ATP8B1 CYP8B1 ABCB11 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC27A5 SCP2 FABP6 HSD17B4 HSD3B7 CYP7B1 CYP27A1 AMACR BAAT SLC10A2 SLC27A2 ABCB1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma EIF4EBP1 PRKAA1 PDPK1 NUMB CTNNB1 RB1 KEAP1 CDKN1A RHEB IGF1R TP63 CSMD3 RELA PRKAA2 SESN1 CCND1 TERT STK11 ERBB2 BIRC2 MAPKAP1 PTEN TP53 NFE2L2 SESN2 EGFR E2F1 RICTOR VEGFA RPS6KB2 CDK6 NOTCH2 CDK4 NOTCH1 LTBR NRAS CASP8 HRAS PIK3R5 FADD CUL3 EIF4E KRAS SMAD4 TRAF3 AJUBA RPTOR IRF6 FGFR3 TSC2 MLST8 FGFR1 AKT2 FAT1 AKT3 MAML1 PIK3CB AKT1 MTOR PIK3CG TSC1 REL CDKN2A FKBP1A RPS6 PIK3R2 PIK3CA PIK3R1 DDIT4 NFKB1 NFKB2 TGFBR2 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260910%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways GAPDH-1 REST PPARGC1A EP300 CPT1A CHRNA4 CTNNB1 GJA1 LOC110384692;C4A;C4B_2;C4B POU2F2 EGR1 CASP3 PRKACB-1 PRKAR2B PRKAR2A NKX3-1 VIPR1 ADCYAP1R1 SSTR2 PRKAR1B VIPR2 PRKAR1A SSTR1 SNAP25 CREB1 YBX1 ASCL1 TNF YWHAE HTR1A YWHAB YWHAQ YWHAH AVP MAOA NKX2-2 DDC CTCF SLC25A4 HTR2A VAMP2 PBX1 IL1B PLP1 TPH1 SLC1A3 POU3F2 CHRNB2 SOX2 BDNF NR3C1 JUN SLC9A3 TPH2 PHOX2B PPARGC1B TAC1 GRIN1 CREM SLC6A4 NEUROD1 CHRNA7;CHRFAM7A RUNX3 TH BHLHE40 YWHAG CHAT HDAC1 NFYA-1 PAH ECE1 YWHAZ NFKB1 NFKB2 IL6R TLX3 CREBBP AR MECP2 RET IL6 TACR1 PKNOX1 IL13 KCNH2 HADHB-1 CHRNB4 TSPYL1 GPD1L-1 ADCYAP1 DLX2 IL10 CEBPB DEAF1 SPTBN1 CXCL8 PHOX2A FEV CHRM2 CC2D1A CDCA7L EN1 ESR2 HTR3A IL1A NOS1AP ATP1A3 SP1 KCNJ8 MBD1 MAP2 GATA3 GATA2 MYB HDAC9 HSPD1 HSP90B1 HES1 VEGFA SCN5A MEF2C HES5 HADHA ACADM GABRA1 POU5F1;POU5F1B GNB3 ALDOA RYR2 SST SCN3B MAZ HIF1A NANOG;NANOGP8 SCN4B SP3 FMO3 IL1RN GCK TF NGF RORA KCNQ1 THRB TPPP PRKACA-1 LMX1B G6PC1 SNTA1 TP73 CAV3 NTRK2 FOXM1 AQP4 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260910%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 XPO1 XPO4 EIF5A;EIF5AL1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism TBXAS1 PTGS1 PTGS2-2 EPHX2 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260910%WP183%HOMO SAPIENS Proteasome degradation UBE2D3-1 NEDD4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 PSMC2-1 IFNG PSMD5 UCHL3 PSME3 UBE2B PSME1 PSME2 PSMD11 PSMD10 UBA7 RPN2 RPN1 PSMB10 PSMB9 UCHL1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2D1 UBB;UBC UBA1 H2AC4 H2AZ2;H2AZ1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 UBE2D3;UBE2D2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMA2-1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMB8 PSMD12 PSMD13 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260910%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation GSTO1 ATP1A1 COA3 SOD1 AS3MT CAT SDHA UQCRFS1 VDAC1 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260910%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP2 LIPC MOGAT3 AGPAT2 DGAT2 DGAT1 AGPAT4 PLPP1 GK GNPAT GPD1 AGPS PNPLA2 MOGAT2 MOGAT1 AGPAT1 AGPAT3 GK2 LIPF GPAM LPL AGPAT5-1 LIPE PLPP3 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260910%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome ARHGAP44 SHARPIN MAP3K7 LZTS3 GRIA1 BAIAP2 ABI1 CAMK2A GRM5 GRIA2 GRM1 HRAS CTTN SYNGAP1 DLGAP1 DBNL DLG4 ARHGEF7 HCN1 HOMER1 CDC42 PAK1 GRIN1 SHANK3 ACTB-1 RAP1A ADGRL1 CTNND2 GRIN2B ITGB1 ITPR1 TAB2 SPTAN1 SERINE METABOLISM%WIKIPATHWAYS_20260910%WP4688%HOMO SAPIENS Serine metabolism SHMT1 SRR PSAT1 PHGDH SHMT2 TYMS PSPH DHFR2;DHFR MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260910%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TRAF6 IRF3 NLRX1 TOMM70 MAVS STING1 REN TICAM1 CGAS BCS1L TRAF3 CTSV;CTSL TMPRSS2 NDUFB9 ECSIT TLR7 TLR3 PHB PHB2 ACE2 ACE ACAD9 AGTR1 AGTR2 IFIH1 TBK1 IRF7 NDUFAF1 IKBKE NFKB1 NFKB2 DDX58 NOX1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260910%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity CS ALDH2 ACO2 ALDH3A2 ACSS2 ALDH9A1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP2571%HOMO SAPIENS Polycystic kidney disease pathway WNT11 MAPK3 PRKAA1 SLC12A2 GNA11 PLCG2 WNT7B IKBKB CTNNB1 FOS RHEB IGF1R PRKAA2 PRKAG1 SFRP4 PRKAG2 EGF VEGFB PRKAG3 SRC DVL1 ADCY6 DVL2 CCND1 MYC PRKAB2 DVL3 STK11 PRKAB1 ERBB2 KCNN4 SSTR2 KDR GNAI3 GNAI2 TNF FZD10 IGF1 WNT5B GNAI1 PKD2 CFTR PDE1A NRAS HRAS WNT6 WNT1 GNAS-1 WNT2 RPS6KA1 WNT4 GNAQ WNT10B WNT10A KRAS FZD2 JUN FZD5 FZD4 FZD7 FZD6 FZD9 FZD8 FZD1 FZD3 WNT3A WNT5A TSC2 WNT7A WNT2B WNT3 PKD1 MTOR TSC1 GSK3B WNT9B WNT9A WNT16 BRAF FLT1 MAP2K2;MAP2K1 WNT8A WNT8B LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP4478%HOMO SAPIENS LTF danger signal response pathway MYD88 TRAF6 TREM1 IL1B AGER IL1A LTF TLR2 CD14 TLR4 TNF IFNB1-4 IL6 IRAK1 IRAK4 NFKB1 MAPK1 CXCL8 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260910%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma SLC2A1 CUL2 CREBBP HIF1A CADM2 COL21A1 ELOC-1 EP300 ELOB CDKN1A VHL FH TFE3 DVL2 PRCC TGFA BIRC7 DIAPH1 PDGFB RBX1 TGFB2 VEGFA SFPQ-1 TGFB1 TGFB3 ARNT TFEB EGLN1 SETD2 EGLN3 EPAS1 CTSK EGLN2 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP561%HOMO SAPIENS Heme biosynthesis UROS PPOX CPOX HMBS ALAD ALAS2 ALAS1 FECH UROD MAPK CASCADE%WIKIPATHWAYS_20260910%WP422%HOMO SAPIENS MAPK cascade MAPK3 LAMTOR3 MAP2K4 NRAS MAP3K2 MAPK14 HRAS MAPK12 ELK1 PLCB3 MAPK10 MAP3K12 RASA3 SIPA1 MAP2K7 RRAS KRAS MAP2K6 GRB2 MAP2K3 JUN MAP3K1 SOS1 RAF1 ARAF MAP2 MBP SOS2 BRAF MAP3K3 MAP2K2;MAP2K1 MAPK1 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260910%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX HPGD ALOX15 EHHADH-1 ALOX12 LTC4S CYSLTR1 DPEP1 PTGR1-1 ALOX5 LTA4H CYSLTR2 ACAA1-1 PTGR2 ACOX1 ACOX3 ALOX15B PPARD CYP4F3;CYP4F2;CYP4F12;CYP4F11 ACOX2 GGT5 TRPA1 LTB4R2 TRPV1 FPR2 LTB4R PPARA G PROTEIN SIGNALING%WIKIPATHWAYS_20260910%WP35%HOMO SAPIENS G protein signaling AKAP8 GNG10 ADCY8 GNG13 GNA11 PRKCD GNGT1 RRAS ADCY4 ADCY2 PRKACB-1 ADCY7 ADCY6 PRKAR2B PRKAR2A PDE4B ADCY5 PDE4A PDE4D-1 PRKAR1B PRKAR1A GNAI3 GNAI2 ADCY9 GNB5 GNA13 GNA12 GNAO1 ARHGEF1 PDE1B ADCY1 PRKCG PRKCI PRKCH CALM1 PRKCB GNB2 PRKCE PRKCA GNB1 ADCY3 GNB3 PRKCQ PPP3CA PRKD1 GNAI1 PPP3CC PDE1A NRAS HRAS PRKCZ PLCB3 AKAP9-1 PDE7A RHOA GNAS-1 GNAQ AKAP12 AKAP10 AKAP11 KRAS PDE8B SLC9A1 PDE8A PDE4C AKAP5 PDE1C AKAP7 AKAP6 AKAP4 AKAP3 GNAZ AKAP1 GNA14 AKAP13 GNA15 GNG5 KCNJ3 GNAL GNG4 PDE7B PRKACA-1 GNG8 PRKD3 ITPR1 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260910%WP585%HOMO SAPIENS Interferon type I signaling RACK1 EIF4EBP1 JAK1 STAT1 MAPK14 STAT3 PTPN11 TYK2 VAV1 GAB2 PDCD4 RAPGEF1 RPS6KB1 CBL PTPRC CRK STAT5A PTPN6 CREB1 MAPKAP1 RPS6KA5 PRMT1 EIF4A1 IRS1 EIF4E IRS2 MAP2K6 MAP2K3 MAP3K1 CRKL STAT4 LCK RPTOR IFNAR2 EIF4B STAT2 MLST8 FYN PIK3CD PIAS1 IRF9 MTOR RPS6KA4 IFNAR1 RAP1A SOCS1 REL PIAS3 RPS6 PIK3R2 PIK3R1 ZAP70 SOCS3 RAC1 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260910%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders DPYS PUS1 CKB UPB1 TYMP TYMS NT5C NT5C3A RRM2B TK2 RRM1 UMPS DHODH DPYD RRM2-1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260910%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CXCL10 TMPRSS2 IL2RA IL2 IL1B CSF3 TNF AGT CCL13;CCL2 ACE2 IL7 IL6 CCL3L1;CCL3L3;CCL3;CCL18 IL10 CXCL8 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling SLC2A1 LDHA PKM SERPINE1 PGK1 HIF1A HK1 BAX SLC16A1 BCL2A1 EDN1 PTGS2-2 BCL2L1 EPO TGFA PFKL NOS2 PDHA1 BIRC5 HIF1AN BNIP3L BNIP3 IGFBP2 TP53 IGFBP1 ANGPT2 ANGPT1 IGFBP3 PMAIP1 VEGFA BAK1 BID MCL1 TGFB3 ARNT EGLN1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260910%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO4A1 SLCO1A2 SLCO3A1 SLC7A5 SLCO1C1 SLC7A8 SLC16A2 SLC16A10 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260910%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 WT1 PTGDS DMRT1 DHH GATA4 MAPK11 FOXL2 CTNNB1 NR5A1 SRY WNT4 AMH INSL3 FGFR2 RSPO1 FST EMX2 SRD5A1 SOX8 SOX9 RBFOX2 CBX2 FGF9 AMHR2 MAPK SIGNALING%WIKIPATHWAYS_20260910%WP382%HOMO SAPIENS MAPK signaling HSPA6 RASGRF2 DUSP16 PPM1A PPM1B PTPN7 ATF2 ELK1 IKBKB FGF21 CHUK FOS RELA FLNA CACNA2D1 EGF CACNA2D3 CACNA2D2 PRKACB-1 CACNA2D4 CACNB1 MYC CACNB2 HSPA8 CACNB3 CACNB4 CACNG6 CACNG7 PDGFB CACNG8 RPS6KA5 PDGFRB CACNG1 FGF2 CACNG2 TNF CACNG3 ATF4 CACNG4 CACNG5 PPP3R1 LRRK2 MKNK1 MKNK2 MAP3K8 TAB2 TAB1 MAP3K14 RASA1 IL1B FLNB PPP3CA FLNC PPP3CB CACNA1B PPP3CC CACNA1A MAPK8 DUSP4 PLA2G4A DUSP2 RPS6KA3 MAPT TNFRSF1A MAP2K7 MAP3K4 MAP2K6 MAP2K3 JUN MAP3K1 TGFBR1-1 DDIT3 NR4A1 RAF1 MAP3K11 AKT2 AKT3 AKT1 MAP3K5 RPS6KA4 MAP3K6 NLK MAP2K2;MAP2K1 CACNA1D MAP3K13 MAPK1 RAC1 CACNA1C MAP3K7 CACNA1F MAPK3 MAP2K4 MAP3K2 PRKCD CACNA1S DUSP6 DUSP1 MAP3K12 IKBKG RRAS GRB2 TRAF2 SOS1 RASA2 FGF20 FGF23 FGF22 IL1A FGF17 FGF16 FGF19 PLA2G4F PLA2G4D PLA2G4E FGF1 GNA12 FGF3 FGF4 SOS2 FGF5 EGFR FGF6 FGF7 FGF8 FGF9 PRKCG FGF14 PRKCA HSPA2 RASGRP1 FGF13 FGF12 FGF11 STK3 CD14 MAP4K3 MAP4K4 MAP4K1 MAP4K2 CACNA1H NGF TAOK2 ARAF FGF18 FGFR4 NFATC1 FGFR3 FGFR2 DUSP10 FGF10 FGFR1 RRAS2 MRAS RAP1B RAP1A MAP2K5 FASLG NTRK2 BRAF MAPK9 MAPK7 LAMTOR3 JMJD7-PLA2G4B;PLA2G4B RAC3 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 NTF4 CDC25B CRK CACNA1I JUND CASP3 MAX CDC42 PAK1 PAK2 RASGRP2 RASGRP4 RASGRP3 TP53 RELB GADD45A SRF RASGRF1 ELK4 MAPKAPK2 FAS BDNF IL1R1 TGFB2 TGFB1 TGFB3 STK4 NFKB1 NFKB2 TGFBR2 TRAF6 NTRK1 ARRB1 ARRB2 PDGFA IL1R2 MEF2C NFATC3 NRAS MAPK8IP2 HRAS NF1 DUSP3 KRAS CRKL PTPN5 STMN1 PRKACA-1 NTF3 ECSIT TAOK1 DAXX HSPA1A;HSPA1B HSPB1 MAPK8IP3 PPP5C PTPRR DUSP8 DUSP9 DUSP7 MAPKAPK3 RAPGEF2 MAPKAPK5 MAPK8IP1 HSPA1L TAOK3 CACNA1E CACNA1G SMIM40 MAP3K20 MELANOMA%WIKIPATHWAYS_20260910%WP4685%HOMO SAPIENS Melanoma MAPK3 STK19 GRM3 RHOB PREX2 PDE5A BAD ERBB4 PTPN11 RB1 CDKN1A RHOC GRB2 CALML6 CALML3 SOS1 CALML4 MITF SHC2 CCND1 PAK1 KDR DDB2 EXOC7 PTEN POLK TP53 MDM2-2 GRIN2A SOS2 E2F1 E2F2 KIT E2F3 BAK1 GADD45B GADD45A CALM1 CALM2 GADD45G CDK6 CDK4 NRAS PIK3R3 BAX HRAS CTTN NF1 RHOA KRAS RAF1 CDH1 CALM3;CALM1 ARAF PIK3CD AKT2 AKT3 VCL PIK3CB AKT1 CDKN2A PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 RAC1 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2879%HOMO SAPIENS Farnesoid X receptor pathway CYP7A1 RXRA FGF19 SLCO2B1 IP6K3 PPARGC1A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC10A1 ABCB4 CYP8B1 FKBP5 NR1H4 IRS2 BAAT ABCB11 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2A1-4 NR0B2 SLC27A5 THERMOGENESIS%WIKIPATHWAYS_20260910%WP4321%HOMO SAPIENS Thermogenesis SMARCD1 KDM3B NPR1 SMARCD2 SMARCD3 UCP1 ADCY8 PRKAA1 SMARCC1 SMARCC2 PRDM16 ACTL6A MAPK14 ATF2 BMP8A;BMP8B PPARGC1A ARID1B MAPK12 SLC25A29 MAPK13 FGF21 CPT1A MAPK11 ACTG1 RHEB PNPLA2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PRKACB-1 LIPE PRKAB2 PRKAB1 CREB1 ARID1A ACTB-1 ADCY1 BMP8B KDM3A RPS6KA3 RPS6KA2 RPS6KA1 MAP2K3 ACSL3 CPT1B CPT2 CREB3L2 CPT1C SMARCA2 TSC2 DPF1 SMARCA4 DPF3 MAP3K5 MTOR RPS6 ACSL6 ACSL5 PRKG1 SMARCB1 SMARCE1 RPS6KB1 CREB3L3 GRB2 CREB3L4 CREB3L1 SOS1 ADCY4 ADCY2 ADCY7 ADCY6 GCG ADCY5 ADCY10 ADCY9 SOS2 ACSL4 SLC25A20 RPS6KB2 ADCY3 NRAS HRAS GNAS-1 KRAS CREB5 CNR1 KLB KDM1A RPTOR PRKACA-1 RPS6KA6 ACSL1 FGFR1 MLST8 PRKG2 ACTL6B TSC1 FRS2 SIRT6 CREB3 ADRB3 PPARG AKT1S1 ZNF516 PLIN1 MGLL 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome ASF1A FOXC2 FOXC1 GP1BA TSKS PITX2 EMC10 ZDHHC8 ZNF274;ZNF74 RCC1 GSC2 TANGO2 C22orf39 CLDN5 CLDN3 THAP7 TSSK2 RTL10 NPRL2 NPRL3 TRMT2A ESS2 CBX5 KLHL22 PI4KA SLC25A1 CDC42 GP5 GP9 LZTR1 LRRC74B AIFM3 MRPL40 PAK4 TNPO1 PLK1 SCARF2 SNAP29 DGCR2 SEPTIN11-1 GP1BB RANGAP1 SLC7A4 GNB1L TP53 SHH DEPDC5 SERPIND1 CCDC188 NCOR1 ARVCF PAX3 LOC102724770;DGCR6;DGCR6L RANBP1 SEPTIN8 ACTA2 RBX1 ALDH1A2 ARNTL SEPTIN5 SRF MAG POLR2A CLTCL1 PPP1CB SREBF1 BCL2 RAF1 FOXA2 MED15 ALDH4A1 COMT PRODH;LOC102724788 SREBF2 KPNB1 GBX2 DRD2 DROSHA DGCR8 HDAC3 RTN4 CDH15 CYP26A1 RTN4R RAN RELN CYP26B1 MALT1 UFD1 TBX1 CDC45 XPO1 PRKN EGFR FGF8 HES1 TXNRD2 NKX2-5 ACTC1;ACTG2 HAND2 CHRD HIRA VWF HIRIP3 CUL3 GLUD1;GLUD2 RORC CLDN1 CRKL SLC2A4 FGFR2 FGF10 FGFR1 P2RX6 OAT SHOC2 H4C1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260910%WP699%HOMO SAPIENS Aflatoxin B1 metabolism CYP2A13;CYP2A6;CYP2A7-1 AKR7A2 GSTM1;GSTM2-1 AKR7A3 CYP1A2 EPHX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260910%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL13A-1 RPS29 RPS20 RPS21 RPS24 RPS23 RPL18A UBA52 RPS6KB1 RPS15A RPS3 RPS2 FAU RPL4 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPL30 RPL7A RPS27A RPS6KB2 RPL37A-1 RPL35 RPL36-1 RPL39 RPL15-1 RPL21 RPL23 RPL22 RPS3A RPL24 RPL29 RPL28 RPL10;RPL10L-1 MRPL19 RPL14 RPL7 RPS6KA3 RPL13 RPS6KA2 RPL12-1 RPS6KA1 RPL18 RPL17 RPL19 RPL35A RPL27 RPL23A RPL3L RPL26 RPS25 RPS27 RPL27A RPL5-1 RPS15 RPS14 RPL11 RPS17 RPS16 RPLP2 RPS6KA6 RPS19 RPS18 RPL38 RPS11 RPS10 RPS13 RPS12 RPL10A RPS9 RPS7 RPS8 RPS5 RPSA RPS6 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260910%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade LCK CD8A CD8B;CD8B2 PDCD1 NFATC1 IFNG STAT3 CD3G PDCD1LG2 PTPN11 CD3E CD274 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 NFATC2 CD3D JUN NFATC3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E NFAT5 ZAP70 NFATC4 BATF NFKB1 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260910%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ITGB3 MYLK PRKCQ MAPK3 CREB1 ITGAV PLCG1 VCL PXN TJP1 MFAP5 JUN PTK2 ACTN1 ITPR1 LPP MYL2 MAPK1 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260910%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways MAPK9 PRKAA1 CKB REST PPARGC1A ELK1 IKBKB MAPK10 RHEB PRKAA2 AHI1 PRKAG1 PRKAG2 EGF PRKAG3 CASP3 PRKAB2 PRKAB1 CREB1 RAB3A RPS6KA5 MBP RICTOR BID IL1B HDAC2 MAPK8 CASP8 BAX HMGCS1-1 MAP2K7 EIF4E BDNF NR1H2 BCL2 ABCG4 ABCG1 MAP3K10 SLC12A5 RAF1 HMGCS2 RAB3GAP1 CYP46A1 NEUROD1 SREBF2 TSC2 HAP1 AKT2 KIF5A AKT3 AKT1 MTOR SIN3A HDAC1 PIK3R2 PIK3R1 ITPR1 NFKB1 MAP2K2;MAP2K1 MAPK1 EIF4EBP1 MAPK3 MAP2K4 SLC12A2 BAD DHCR7 IL6 RPS6KB1 PRR5L BCL2L1 APOE OPA1 ABCA1 SP1 PTEN BNIP3 HTT EGFR GABRB3 CASP7 GABRB2 GABRB1 GABRG3;GABRG2 GABRE GABRD GABRQ GABRA2 GABRA1 GABRP DEPTOR GABRA6 GABRA5 GABRA4 GABRA3 GABRG1 PIK3R4 CYP51A1 PIK3R3 GRM1 HRAS PIK3R6 PIK3R5 RPTOR MLST8 BCL2L11 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG HMGCR TSC1 PIK3C2B NTRK2 PIK3CA AKT1S1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260910%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination FGFR2 MAPK11 FOXL2 CTNNB1 AXIN1 RHOA SRY SOX9 WNT4 GSK3B MAP3K4 FGF9 MAP3K1 ROCK1 MAPK1 GADD45G SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260910%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling HTR4 HTR6 ELK4 ATF1 MAPKAPK2 MAPK3 CREB1 HTR7 RPS6KA5 ELK1 GNAS-1 RAP1A BRAF NR3C1 EGR1 MAP2K2;MAP2K1 MAPK1 SRF TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260910%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc DLST PC OGDH ACO1 PDHA1 ACLY SUCLG2 IDH3A CS MDH1 DLAT IDH1 DLD SDHA FH PCK1 FOCAL ADHESION%WIKIPATHWAYS_20260910%WP306%HOMO SAPIENS Focal adhesion ELK1 ACTG1 FLNA ACTN1 EGF FN1 ACTN4 TNC CCND1 ERBB2 KDR PDGFB PDGFRB ACTB-1 IGF1 FLNB FLNC MAPK8 JUN BCL2 RAF1 MYL5 MYL7 TLN2 TXK TNK2 MYL12A TNK1 MYL10 SRMS PTK6 PARVB MYLPF AKT2 PARVG AKT3 ARHGAP5 AKT1 MYLK4 FGR STYK1 GSK3B PIK3R2 PIK3R1 MAP2K2;MAP2K1 MAPK1 RAC1 PDGFD MAPK3 PDGFC PPP1R12A COL1A1 COL1A2 BAD VAV1 HCK IGF1R TNXB GRB2 SOS1 RELN VEGFB SHC4 SHC1-1 SHC2 VEGFD IBSP TNN TNR PDGFRA COL4A2 COL4A1 PTEN COL4A4 COL4A6 EGFR VTN CHAD PRKCG COL5A3 PRKCB COL5A2 PRKCA LAMC3 LAMC2 PIK3R3 LAMC1 XIAP VWF COL6A2 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 MYLK2 THBS4 BUB1B-PAK6;PAK6 THBS3 ITGA2B CAPN2 LAMB3 LAMB2 LAMB1 TLN1 PIK3CD VCL SHC3 PIK3CB PXN RAP1B RAP1A VASP CAV3 CAV2 CAV1 BRAF PTK2 PIK3CA ITGA10 FLT1 ITGA11 ITGB1 PGF ITGB5 ITGB4 ITGB3 ILK MAPK9 RAC3 ITGB8 ITGAV ITGB7 ITGB6 VAV3 ITGA4 PDPK1 MAPK10 ITGA3 CTNNB1 ITGA2 ITGA1 VAV2 ITGA8 RAPGEF1 ITGA7 ITGA6 ITGA5 CCND3 CRK CCND2 DOCK1 ITGA9 ROCK1 ROCK2 SRC CDC42 PAK1 PAK3 PAK2 PAK4 BIRC2 BIRC3 COMP PPP1R12B ZYX BCAR1 EMP2 ARHGAP35 RASGRF1 PPP1CA PPP1CB PPP1CC FYN MYL12B PIP5K1C HGF PDGFA MYLK SPP1 PPP1R12C BLK VEGFA MYLK3 MYL2 HRAS RHOA TESK2 CRKL MET DIAPH1 PARVA COL2A1 THBS1 VEGFC FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260910%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 VLDLR LIPC SCARB1 PLTP APOA1 CETP LRP1 APOA2 APOE LPL LDLR LCAT CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260910%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling JUNB MAPK9 MAPK3 CYP11A1 GNA11 PLCG2 PRKCD MAPK14 ELK1 TFAP2A CTNNB1 ARRB1 JUP POMC ARRB2 FOS GJA1 RELA CASP9 PRKAA2 JUND NFKBIA CASP3 CXCL8 IL18 FOSL1 STAR IL2 GRK3 SP1 CREB1 GNAI2 TLR4 NCOA2 CRHR1 KRT16;KRT14 CRHR2 GNB5 GNAO1 RAPGEF3 CYP21A2 PRKCI PRKCB GNB2 PRKCA GNB1 TCF4 GNB3 PRKCQ GNAI1 MAPK8 CAMK2A PLCG1 PARP1 HSP90AA1 RHOA GNAS-1 CACNA1H GNAQ ACACA NR4A2 CYP11B1;CYP11B2 BCL2 NR4A1 GNAZ RAF1 TRIM28 HSD3B1;HSD3B2 NOS3 AKT1 MAP3K5 RAP1B CRHBP KRT1 ERN1 IVL GRK6 GSK3B TBX19 FOSL2 BRAF FOSB ECE1 SULT2A1-4 PTK2 TGFB1 MAP2K2;MAP2K1 NFKB1 MAPK1 CRH UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260910%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts GFPT1 GCK HK2 UGDH GALE UXS1 PGM1 HK1 HK3 GPI PGM3 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP5304%HOMO SAPIENS Cholesterol metabolism APOA4 LIPC APOC2 SCARB1 ANGPTL8 APOH ANGPTL3 PLTP EBP NSDHL SC5D DHCR24 DHCR7 LBR APOA1 ABCB11 APOE LDLR ABCA1 STAR LIPA STARD3 VDAC1 OSBPL5 APOC1 SORT1 CYP7A1 CD36 IDI1 CYP51A1 MVK MSMO1 HSD17B7 ACAT2 TM7SF2 HMGCS1-1 PMVK PCSK9 LIPG FDFT1 LDLRAP1 MYLIP MTTP FDPS LSS SAR1B TSPO NPC1L1 MGAT1 APOB ABCG8 ABCG5 FABP2 SQLE SOAT1 APOC3 SLC27A4 DGAT1 NPC2 MVD HMGCR CYP27A1 CETP NPC1-1 LRP1 LRPAP1 APOA2 CIDEB LPL VAPA LCAT PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260910%WP3527%HOMO SAPIENS Pre implantation embryo CELF3 NR3C2 FOXQ1 MACROH2A2 KHSRP ZAR1 KLF4 AQP9 DPPA3 PADI6 BARX2 CDX2 LEUTX ZFP36 NLRP5 MTA3 DPRX-1 MOS TPRX1;RAX2 ZSCAN4 TBX3 NKX2-1 EGR1 DLX2 IRX5 FOXD1 GATA3 SOX8 GATA2 MYBL1 ATP1A1 E2F5 TCF7L1 ZFP42 POU5F1;POU5F1B PBX1 DNMT3L NANOG;NANOGP8 ELAVL1 TEAD4 SOX11 HNRNPAB SOX2 ESRRA MXD1 DDIT3 CDH1 SMARCA4 TFAP2E;TFAP2B IRF4 BATF3 ZFP36L2 SIX3 FOSB NANOGNB AQP3 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260910%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence GOT1-1 SLC2A1 SLC2A4 IL1B PRKAA1 PARP1 ELAVL1 SIRT5 TP53 SIRT1 NMNAT2 MDH2 SIRT2 SIRT3 G6PD MDH1 IL6 CCL27 NAMPT GOT2-1 RELA HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260910%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 BMP4 RUNX2 SMO FOXI3 GTPBP4 CTNNB1 GJB6 SNAI1 TP63 GLI1 LAMA5 CCND2 PTCH1 PDGFA CCND1 CDH1 MYC EDA FZD1 WNT5A FGFR2 PDGFRA GLI2 SHH FGF1 LEF1 INHBA NCAM1 ITGB1 LRP5 NFKB1 EDAR INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260910%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 MTOR INSR RPS6KB1 IRS1 TBC1D4 RPS6 AKT2 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260910%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity ITGB3 ITGB2 CFP ITGAX ITGAV PROS1 CLU MPP5 C8G C3AR1 LOC110384692;C4A;C4B_2;C4B C5AR2 CR2 CASP9 MASP2 MASP1 CASP3 CFB CFD C1QB C1S APAF1 C1R CFI C5AR1 C2 CX3CR1 C6 C7 C9 CD55 C8B C8A CR1L;CR1 MBP CYCS-1 CFH-3 BID PARD3 PARD6B CASP8 FAS BAX MBL2-1 CX3CL1 MFGE8 ATP8B2 TGFB2 TGFB1 TGFB3 C3-1 C1QC CAP1 PATJ C4BPA C4BPB ATP8B1 FCN2;FCN1 ATP10A ATP11C SCRIB ATP11A TYRO3 LLGL2 MARK3 ATP8B3 DLGAP5 C5 PLSCR1 PLSCR3 PLSCR4 GAS6 CRB2 COLEC12 CRB1 COLEC10 PARD6G SUSD4 IFNG CD59 CSMD1 DEDD DIABLO-1 MERTK HTRA2 VTN CASP7 BAK1 PRKCI PRKCZ XIAP SERPING1 PARD6A AXL MARK2 MARK1 FASLG COLEC11 CASP10 ITGAM MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260910%WP391%HOMO SAPIENS Mitochondrial gene expression PPP3CA SP1 CREB1 NRF1 GABPB1 MTERF3 TFB2M CAMK4 PPARGC1A MTERF1-1 TFB1M PPRC1 TFAM-1 HCFC1 MYEF2 GABPA POLRMT ESRRA PPARGC1B ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260910%WP2374%HOMO SAPIENS Oncostatin M signaling JAK2 JUNB MAPK9 MAPK3 JAK1 STAT1 PRKCD MAPK14 STAT3 PTPN11 TYK2 JAK3 CDKN1B FOS OSMR RELA GRB2 IL6ST SOS1 STAT5B EGR1 JUND NFKBIA SHC1-1 CASP3 CEBPB OSM SRC CREB1 PTK2B CASP7 RICTOR VEGFA PRKCH PRKCB PRKCE PRKCA CDK2 MAPK8 HIF1A HRAS IRS1 KRAS RAF1 AKT1 PXN MTOR LIFR PIAS3 RPS6 PIK3R1 SOCS3 MAP2K2;MAP2K1 NFKB1 MAPK1 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260910%WP5241%HOMO SAPIENS Mitochondrial beta oxidation EHHADH-1 ECHS1 DECR1 ACAA2 ECI1 ACSL3 HSD17B10 ACADSB ACADL HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260910%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling JAK2 IL6R MAPK3 NGFR NTRK1 STAT3 ELK1 IKBKB PPARD CTNNB1 IKBKG CHUK RUNX1T1 CDKN1A JUP FOS ZBTB16 IL6 RHEB IGF1R RELA GRB2 SOS1 NFKBIA SHC1-1 SRC CCND1 MYC INSR KDR PDGFRA FLT4 ULK2 PDGFRB PTEN SALL4 TP53 MDM2-2 CSF1R AXIN2 SOS2 LEF1 EGFR KIT CSNK1A1 PML BCL9 APC DEPTOR TELO2 HRAS WNT1 KRAS TTI1 FOXO1-1 JUN FZD6 RAF1 MET NFKBIE RPTOR FGFR4 FGFR3 FGFR2 TSC2 FLT3 MLST8 FGFR1 LRP6 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR PIK3CG TSC1 RETN TEK KSR1 RARA GAREM2 REL GSK3B NTRK2 BRAF PIK3CA PTK2 FLT1 AKT1S1 PYGO1 LRP5 MAP2K2;MAP2K1 NFKB1 EPHA2 MAPK1 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260910%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBZ HBG2;HBG1 LDB1 HBA2;HBA1 TAL1 LMO2 GATA1 HBD;HBB GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260910%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TCTN2 TCTN1 BBS9 BBS7 CEP97 CLUAP1 CC2D2A BBS5 ARMC9 RPGRIP1L TMEM216 CEP104 ARL3 ARL13B MIB1 TMEM67 INPP5E PIBF1 BBS2 BBS1 MKS1 CPLANE1 TMEM231 TTC8 TMEM17 KIF3A B9D1 EVC2 TTC21B EVC KIAA0753 OFD1-1 CEP20 BBS4 IFT172 IFT74 CEP192 TRAF3IP1 IFT88 CEP19 TXNDC15 CDK20 TRAPPC11 KIFAP3 WDPCP TEDC1 TEDC2 ARL6 FBF1 TTBK2 KIF3B CEP76 CPLANE2 SASS6 CEP83 CIBAR1 TTC23 C2CD3 CBY1 EFCAB7 TMEM107 MKKS CEP295 BBS10 BBS12 CILK1 TUBD1 TULP3 KATNB1 RAB23 SCLT1 TUBE1 RABL2A;RABL2B CEP162 CEP44 DYNC2H1 DYNC2I2 CEP43 LZTFL1 DYNC2I1 TTC30A;TTC30B DYNLT1 IFT140 DYNLT2B WDR19 IFT122 IFT80 FUZ WDR35 HSPB11 DYNC2LI1 IFT20 IFT43 IFT81 IFT27 TTC26 IFT46 IFT52 IFT57 CEP120 TCTN3 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260910%WP5174%HOMO SAPIENS Ulcerative colitis signaling NFATC1 IL4 FOXP3 IFNG MAF TLR2 TNF IL5 GATA3 IL2RG STAT6 IL13 IL4R TGFB1 NOD2 HLA-DMA IL10 NFKB1 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260910%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer POLE2 RPA3 RRM1 MAPK13 RB1 CDKN1A SMC3 POLA1 CDKN1B MCM7 RRM2-1 SKP2 CCND3 CDC25B TFDP1 TFDP2 MCM3 MCM4 CHEK1 MCM6 CCND1 FAF1 MYC PRIM1 HMGB2 SMC1A CDC45 CDC25A ORC1 HMGB1-1 TOP2A CDC7 CCNE2 CCNE1 WEE1 TP53 MDM2-2 CCNA2-1 PRMT2 CCNB2 CCNB1 ANLN ABL1 E2F1 E2F2 BARD1 CDT1 MSH6 TTK E2F3 RPA2 CDK6 H2AZ2;H2AZ1 DNMT1 CDK4 CDK2 PRKDC CDK1 TYMS FANCG DHFR2;DHFR SMC2 KIF4B;KIF4A DCK NPAT HLTF POLE PLK4 RABIF RFC5 RBBP7 ZNF655 RFC3 CCDC6 RFC4 RAF1 STMN1 SMARCA2 SUV39H1 POLD3 SAP30 RBP1 PCNA SIN3A HDAC1 RPA1 RBBP4 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260910%WP4271%HOMO SAPIENS Vitamin B12 disorders CBLIF CD320 MMAB MTRR TCN2 TCN1 MTR-1 CUBN MMUT AMN MMAA MMACHC MMADHC 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome POLR1A POLR1B ARF6 POLR1D CSF2 POLR1E PLCG2 STAT1 IL6 LGALS3 GRB2 IL36A IL36B IL36G ANAPC1 GAS6 IL1F10 IL2 IL1A MERTK CXCL13 GATA3 CSF1 IL1RAP IL37 IL36RN IL1B IL1RL2 POLR1C IL1RN ZC3H8 ZC3H6 CHCHD5 ACOXL POLR2L PSD4 ARL14 CKAP2L IL1R1 IL23A POLR1F POLR1G POLR1H FBLN7 TMEM87B SLC20A1 BCL2L11 TULP1 TTL SOCS1 POLR2E POLR2F POLR2H PTK2 SOCS3 MAPK1 RAC1 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260910%WP3286%HOMO SAPIENS Copper homeostasis MT3 SLC31A1 MTF1 MT2A BACE1 CCS XIAP MTF2 MAPT SLC11A2 COX11 STEAP3 APP FOXO1-1 JUN ADAM9 CASP3 CCND1 STEAP4 SOD3 SOD1 SP1 PTEN FOXO3 AKT1 TP53 MDM2-2 COX17 ATP7B ATP7A PRNP SLC31A2 COMMD1 ADAM17 ATOX1 GSK3B SCO1 STEAP1 STEAP2 PIK3CA ADAM10 APC OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis FADS2 ACSL1 SCD FADS1 ELOVL2 ELOVL5 ACOT2;ACOT1 ELOVL1 ELOVL3 SCD5 ACSL3 ELOVL6 ACSL4 FASN SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome RAD50 NBN SMC3 MRE11 SMC1A PAXIP1 RAD21 BRCA1 RAD18 ATM MDC1 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260910%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 MTOR INSR RPS6KB1 IRS1 TBC1D4 RPS6 AKT2 IL9 SIGNALING%WIKIPATHWAYS_20260910%WP22%HOMO SAPIENS IL9 signaling IL9 IL9R MAPK3 JAK1 STAT1 STAT3 JAK3 IL2RG GRB2 PIK3R2 PIK3R1 STAT5A STAT5B CDK9 MAP2K2;MAP2K1 MAPK1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260910%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX18 HIGD1A PET117 COX14 COX10 CMC1 TMEM177 PNKD NDUFA4 SMIM20 COX20 COX6A1 COX11 COX6B1 COX7A2 COX7B COX4I1 COX7C COX8A COX5B COX5A COX6C COX17 COA3 SURF1 COX19 COX15 TACO1 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260910%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway MSN RHOA RACGAP1 EZR ANLN SEPTIN2 RAB35 RDX AFAP1 MYL2 KIF23 OCRL TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP75%HOMO SAPIENS Toll like receptor signaling CXCL10 TRAF6 MAP3K7 IRF3 MAPK9 MAPK3 NFKBIB MAP2K4 STAT1 MAPK14 MAPK12 IL12B MAPK13 IKBKB MAPK10 MAPK11 IKBKG CHUK LBP FOS IL6 RELA CCL3L1;CCL3L3;CCL3;CCL18 NFKBIA CXCL8 CCL4L2;CCL4L1;CCL4 TICAM2 SPP1 TIRAP TLR1 TLR9 TLR8 TLR6 IL12A TLR7 TLR4 TNF TLR3 IFNB1-4 CXCL9 IRAK1 MAP3K8 IRF7 TOLLIP TAB3 CXCL11 TAB2 TAB1 MYD88 IL1B MAPK8 CASP8 LY96 CD14 RIPK1 FADD TICAM1 MAP2K7 MAP2K6 MAP2K3 JUN TRAF3 CD40 IFNAR2 TLR5 TLR2 CCL5 AKT2 AKT3 CD86 AKT1 CD80 IFNAR1 IRF5 TBK1 IRAK4 IKBKE MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy JAK2 JUNB MAPK3 COL1A1 NTRK1 STAT3 CCN2 GANC DDR2 CNMD P4HTM FOS LAMTOR1 RELA ACAN JUND CEBPB VHL FOSL1 COL3A1 FGF23 IBSP SPP1 KDR SOX9 RELB VEGFA PRKCA RUNX2 COL10A1 HIF1A NGF JUN FGFR4 MMP13 FGFR3 FGFR2 FGFR1 AKT2 COL2A1 AKT3 AKT1 FOSL2 FOSB PIK3CA ARNT NFKB1 MAPK1 EPAS1 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA1 HEXB B3GALT4 ST3GAL4 ST8SIA5 ST3GAL1 ST3GAL2 HEXA NEU3 ST8SIA6 NEU4 ST3GAL5 B4GALNT1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260910%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome MAPK9 MAPK3 PRKAA1 MAPK8 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 G6PC2 G6PC3 PRKAA2 ACACA PRKAG1 PRKAG2 ACACB PRKAG3 PRKAB2 PRKAB1 ACLY PCK2 G6PC1 CRP SLC27A2 MAPK1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260910%WP2324%HOMO SAPIENS AGE RAGE pathway JAK2 MAPK9 AGER MAPK3 ALPL STAT1 PRKCD MAPK14 ATF2 STAT3 INHBB IKBKB CHUK LGALS3 MMP2 DDOST RELA CASP9 MSR1 MMP9 STAT5A STAT5B NFKBIA SHC1-1 CASP3 ROCK1 FOXO4 SRC CDC42 MSN NOS2 INSR TIRAP SOD1 SP1 NCF1 CYCS-1 EGFR PRKCB PRKCA MYD88 EZR MAPK8 HIF1A CASP8 PRKCZ PLA2G4A RHOA IRS1 FOXO1-1 JUN INS;INS-IGF2 MMP7 RAF1 SMAD2;SMAD3 MMP14 MMP13 DIAPH1 NOS3 AKT1 IRAK4 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260910%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD AHRR CDK2 NRAS NCOR2 CD36 HRAS FGF21 HSP90AA1 CYP1A2 RET EP300 NF1 RB1 CDKN1A CDKN1B CYP1A1 KRAS RELA PTGS2-2 PLAGL1 HPGDS AIP KLF6 PSRC1 NCOA7 ESR1 GCLC SRC RAF1 MYC NRIP1 NQO1 CCL1 TNF CDC37 NFE2L2 CYP1B1 AHR EGFR E2F1 VEGFA ARNT MAP2K2;MAP2K1 NFKB1 LPL MAPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260910%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TCF4 CDH1 SIX1 HDAC2 SUV39H1 ELF3 FOXC2 ZEB1 EZH2 SIRT1 ZEB2 GSC2 SNAI1 SNAI2 GRHL2 PRRX1 HDAC1 TGFB1 KDM1A KLF8 SUZ12 ELF5 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260910%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling JAK2 MAPK3 JAK1 MYL12B APEX1 STAT1 MAPK14 STAT3 PDPK1 RB1 TSHR CDKN1B IGF1R RPS6KB1 SCRIB CCND3 PLD1 ADCY2 CGA SRC KCNIP3 PDE4D-1 CREB1 GNAI3 RALGDS GNAI2 CCNE1 GNA13 GNA12 GNAO1 GNB1 ADCY3 GNAI1 CDK4 CDK2 HRAS RAP1GAP GNAS-1 RPS6KA1 GNAQ PLCB1 MAP2K6 MAP2K3 RAF1 GNG2 RBL2 TSHB AKT1 MTOR RAP1B RAP1A RPS6 PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 ERYTHROPOIESIS%WIKIPATHWAYS_20260910%WP5607%HOMO SAPIENS Erythropoiesis EPO KITLG CD79A HBA2;HBA1 FAS EPOR GDF11 GATA2 HBZ TFRC IL3 FASLG TF HBG2;HBG1 PTPRC IL3RA CD34 KIT GATA1 HBD;HBB PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260910%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases KHK H3-3A SNAP23 PAK2 PKM PGK1 PRPS1 PDK1 STAT3 BUB3 AKT1S1 BECN1 MYL2 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260910%WP5461%HOMO SAPIENS Primary ovarian insufficiency COX10 PPM1B ATG9A PCCA PCCB POLG RFWD3-2 ESR1 PRORP RCBTB1 NBN STAR MEIOSIN POF1B MEIOB SIL1 SOHLH2;CCDC169-SOHLH2 HFM1 NANOS3 BMP15-1 LARS2 SGO2 PREPL NOBOX KHDRBS1 AARS2 SOX8 AIRE SYCP2L MST1R HMMR WDR62 LIG4 BLM SYCE1 ANTXR1-1 SOHLH1 ZP3;POMZP3 KASH5 AMHR2 SWI5 HELQ ERAL1 HARS2 FIGLA DAZL CPEB1 GDF9 DIAPH2 STAG3 FSHR MSH5 H1-8 HROB DMC1 LHX8 FANCI BNC1 RAD51 FANCM MCMDC2 XRCC4 ELAVL2 FANCL C1orf146 LMNA FANCA MRPS22 TWNK WT1 FANCC SPIDR C14orf39 HAX1 LGR4 GALT ATM SLX4 SHOC1 CCDC185 MGME1 MND1 CENPE XPNPEP2 SPATA33 EXO1 EIF2B2 WRN NUP107 PRDM1 MLH1 EIF4ENIF1 CYP19A1 POLR2C ZAR1 AR POLR3H ERCC6 PSMC3IP FOXL2 NR5A1 AMH TP63 DCAF17 NUP43 ESR2 MSH4 STRA8 CLPP SALL4 BRCA2 XRCC2 HSD17B4 HSD17B1 ATG7 ALOX12 NOTCH2 CYP17A1 FMR1 LAMC1 GNAS-1 BMP6 EIF2B1 EIF2B5 EIF2B4 BMPR1B BMPR1A PMM2 BMPR2 TGFBR3 MCM8 MCM9 CAV1 PGRMC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260910%WP51%HOMO SAPIENS Regulation of actin cytoskeleton RAC3 MAPK6 GIT1 MAPK4 WAS RDX FGF21 ITGA1 ACTG1 ARHGEF7 CRK ACTN1 DOCK1 EGF FN1 ROCK1 ROCK2 CDC42 PAK1 CSK PAK3 PAK2 PAK4 PDGFB PDGFRB FGF2 BCAR1 ACTB-1 ARHGAP35 CHRM1 PIP4K2A WASF1-1 NCKAP1 MYH10 SLC9A1 RASSF7 ARPC5 SSH2 SSH3 SSH1 VIL1 DIAPH3 PIP5KL1 ARHGEF4 RAF1 ARHGEF6 FGD1 WASF2 ABI2 PIK3R2 PIP4K2B PIK3R1 PIP4K2C MAP2K2;MAP2K1 MAPK1 RAC1 ENAH MAPK3 PPP1R12A PIP5K1A PIP5K1B PIP5K1C MOS VAV1 RRAS F2 PFN1 SOS1 CHRM4 CHRM5 PDGFA MSN FGF20 CHRM2 MYLK FGF23 FGF22 CFL1 FGF17 FGF16 PDGFRA FGF19 F2R APC2 GNA13 FGF1 GNA12 FGF3 ARHGEF1 FGF4 SOS2 FGF5 IQGAP1 FGF6 EGFR FGF7 FGF8 FGF9 FGF14 CYFIP2 MYL1 APC MYL3 EZR FGF13 BAIAP2 FGF12 FGF11 NRAS PIK3R4 PIK3R3 CD14 PIK3R5 GSN RHOA KRAS BDKRB2 BUB1B-PAK6;PAK6 CFL2 FGF18 PAK5 FGFR4 FGFR3 LIMK1 FGFR2 DIAPH1 FGF10 FGFR1 PIK3CD RRAS2 VCL PIK3C2G BDKRB1 MRAS PIK3CB PXN PIK3C2A CHRM3 PIK3CG PIK3C2B BRAF PTK2 PIK3CA PIK3C3 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response RAD52 CCND1 CDK6 MYC CDC25A CREB1 CCNE1 ATM TP53 CDKN1A CDKN1B ABL1 E2F1 CCND3 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP4149%HOMO SAPIENS White fat cell differentiation IRF3 NR1H3 KLF4 SREBF1 WNT10B CEBPA NR2F2 NR3C1 FOXO1-1 TLE3 RORA INS;INS-IGF2 STAT5A STAT5B DDIT3 CEBPB MECOM CTNNA1 EBF1 CREB1 EGR2 CEBPD GATA3 GATA2 KLF15 KLF2 KLF5 IRF4 ZNF423 RARA PPARG TCF7L1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260910%WP1971%HOMO SAPIENS Integrated cancer pathway RAD50 JAK1 POU2F1 CDK4 CDK2 CDK1 STAT1 CASP8 BAD BAX ATM BACH1 ATR MMP1 RB1 CDKN1A CDKN1B MRE11 BRCA1 BBC3 CASP9 CDC25B CHEK2 CASP3 BCL2 CHEK1 SMAD2;SMAD3 MYC ATF1 CDC25A PLK1 PTEN CDKN2B AKT1 TP53 MDM2-2 MAP3K5 BLM E2F1 BARD1 NOXA1 MSH6 MSH2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260910%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells NRAS HRAS CTNNB1 HGF KRAS SMAD4 TGFBR1-1 SMAD2;SMAD3 RAF1 MET TGFA ERBB2 PROM1 WNT3A WNT5A DKK4 AKT1 TGFBR3 MTOR AXIN1 MFGE8 EGFR TGFB2 TGFB1 TSPAN8 TGFB3 TGFBR2 APC PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases CPS1 GLS2 DPYS CAD UPB1 OTC TYMP ABAT TYMS NT5C AGXT2 NT5C3A RRM2B TK2 RRM1 UMPS DHODH ALDH6A1 DPYD RRM2-1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260910%WP2878%HOMO SAPIENS PPAR alpha pathway ACADM APOA5 CCND1 APOC3 MYC EHHADH-1 NR1H3 FABP1 CYP7A1 CDK4 KLK15 RXRA CDK1 PLTP SCP2 ACAA1-1 CPT1A CYP8B1 PPARA APOA1 SLC27A1 APOA2 CPT2 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260910%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG GNAQ PCSK1 SLC2A2 SLC5A1-1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260910%WP2338%HOMO SAPIENS miRNA biogenesis DICER1 TARBP2 RAN XPO5 DROSHA DGCR8 BLADDER CANCER%WIKIPATHWAYS_20260910%WP2828%HOMO SAPIENS Bladder cancer CDK4 NRAS HBEGF HRAS MMP1 RB1 CDKN1A MMP2 KRAS MMP9 DAPK2 EGF DAPK3 CXCL8 SRC RAF1 CCND1 CDH1 ARAF MYC ERBB2 FGFR3 TYMP UPK3A RPS6KA5 TP53 MDM2-2 THBS1 DAPK1-1 EGFR E2F1 CDKN2A PIK3R2 BRAF VEGFA PIK3R1 RASSF1 MAP2K2;MAP2K1 MAPK1 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260910%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway CXCL10 POLR3B RNF125 IRF3 POLR3D POLR3E NFKBIB POLR1D NLRX1 CYLD MAVS POLR3H TREX1 STING1 POLR3K IKBKB ISG15 IKBKG CHUK CGAS IL6 RELA NFKBIA IL18 CCL4L2;CCL4L1;CCL4 IL33 IFNB1-4 PYCARD CASP1 IRF7 ATG12-1 ATG5 IL1B CASP8 RIPK3 TRADD RIPK1 FADD POLR1C POLR2L ZBP1 CCL5 POLR3GL POLR3A ADAR POLR3C POLR3F POLR3G AIM2 POLR2E POLR2F TBK1 CASP10 POLR2H TRIM25 IKBKE NFKB1 DDX58 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260910%WP5526%HOMO SAPIENS Age related macular degeneration PRKAB2 RPTOR PRKAB1 MAPK3 PRKAA1 MLST8 PPARGC1A SIRT1 MTOR MDH1 RPS6KB1 PMAIP1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 PARP2 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260910%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGFR PTGER3 HPGD PTGS1 TBXA2R CYP11A1 PTGDR PTGIR PTGDS CBR1-1 PPARGC1A PTGIS PLA2G4A EDN1 ANXA2 ABCC4 ANXA1 TBXAS1 PTGS2-2 AKR1B1 HPGDS MITF PPARGC1B HSD11B1 HSD11B2 ANXA5 ANXA8;ANXA8L1 PTGER4 ANXA6 PTGFRN SOX9 S100A10 PTGER2 PRL ANXA3 ANXA4 SCGB1A1 S100A6 EDNRA PPARG EDNRB PTGES PTGER1 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260910%WP4963%HOMO SAPIENS p53 transcriptional gene network RPRM ULBP3;ULBP1;RAET1G;ULBP2;RAET1L SIVA1 PRKAA1 SERPINE1 ICAM1 ISG15 BTG2 SAT1 TIGAR CDKN1A SLC7A11 BBC3 PRKAA2 PIDD1 PRKAG1 PRKAG2 PRKAG3 SESN1 PRKAB2 APAF1 TRAF4 PRKAB1 FUCA1 TP53I3 CDC25C CDC25A DDB2 ULK2 RRM2B ULK1 PTEN TNF CCNE1 POLK TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SESN2 TP53INP1 PMAIP1 SFN LIF MSH2 GADD45A PML XPC SLC2A1 DEPTOR GLS2 CDK2 NOTCH1 CCNG1 FANCC FAS NANOG;NANOGP8 BAX GPX1 NCF2 CX3CL1 POLH ERCC5;BIVM-ERCC5 ALDH4A1 RPTOR CPT1C TSC2 MLST8 IRF9 MTOR CCL13;CCL2 FASLG THBS1 ADORA2B PCNA IRF5 XRCC5 ACAD11 SERPINB5 MGMT SCO2 ADGRB1 ULBP1-2 AURKA AKT1S1 DDIT4 DRAM1 ZMAT3 MLH1 PERP E2F7 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEDS1-UBE2V1;PEDS1 PEX19 LPCAT1 PEX1 PEX7 PEX16 ALDH3A2 PEX5L LPIN3 DHRS7B AGMO DGKQ FAR2 ACAD10 CEPT1 ARSA UGT8 GNPAT GAL3ST1 AGPS LPIN1 LPIN2 FAR1 PEX3 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260910%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 G13 SIGNALING%WIKIPATHWAYS_20260910%WP524%HOMO SAPIENS G13 signaling ARHGDIB CYFIP1 WAS PIP4K2A MAPK10 RTKN SH3RF1 PPP1CB RHPN2 RHOA MYBPH PKN1 CIT RPS6KB1 MAP3K4 PFN1 ROCK1 ROCK2 CDC42 CFL2 PAK3 CFL1 TNK2 LIMK1 DIAPH1 PIK3CD PIK3CB GNA13 ARHGEF1 IQGAP1 ARHGDIG IQGAP2 PIK3R2 PIK3CA CALM1 WASL RAC1 MYL1 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260910%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA2 ITGB2 SELPLG VCAM1 SELE MADCAM1 ITGB7 ITGB1 ICAM1 ITGA4 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260910%WP2197%HOMO SAPIENS Endothelin pathways PRKCA GNAI1 GNG13 NPY PTGIR NPY1R GNAS-1 EDN1 PLCB1 ATP2A2 CNN1 RIIAD1 ADRA1A RAMP1 CALCA ADRB1 RAF1 GNA15 MYLK CALCRL CAD NOS3 ADCY10 GNB5 ECE1 EDNRA EDNRB MAP2K2;MAP2K1 CALM1 MAPK1 MYL1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260910%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK CYP2E1 MAPK8 SP1 MAP2K2;MAP2K1 MAFF NFE2L2 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260910%WP438%HOMO SAPIENS Non homologous end joining XRCC6 NHEJ1 XRCC4 XRCC5 LIG4 PRKDC POLM POLL WRN DCLRE1C CILIOPATHIES%WIKIPATHWAYS_20260910%WP4803%HOMO SAPIENS Ciliopathies TCTN2 CSPP1 GAS8 TCTN1 BBS9 LCA5 BBS7 CEP290 CLUAP1 CC2D2A BBS5 RPGRIP1L TMEM138 RP2 CCDC65 TMEM216 ANKS6 CEP104 ARL3 ARL13B TMEM67 INPP5E NPHP1 PDE6D NPHP3 AHI1 PIBF1 RSPH9 NEK8 BBS2 BBS1 NEK9 MKS1 CPLANE1 TMEM231 TTC8 TMEM17 RSPH3 KIAA0586 TMEM237 UNC119 B9D1 EVC2 CEP41 B9D2 TTC21B GLI2 KIF7 EVC INVS RSPH4A RSPH1 KIAA0753 OFD1-1 OCRL BBS4 ZIC2 CRX ODAD1 GALNT11 ODAD3 ODAD2 ODAD4 MCIDAS TBC1D32 NEK1 NEK2 DNAAF3 ADCY6 IFT172 DNAAF2 DNAAF1 DNAAF6 DNAAF5 DNAAF4 CFAP410 RP1-2 FAM161A MAK CFAP298;CFAP298-TCP10L CCNQ TRAF3IP1 CCNO AK7 GLIS2 PKHD1 CEP78 INTU DNAH11 CEP19 DCDC2 C8orf37 GPR161 ARL2BP DNAL1 ALMS1 WDPCP HYDIN TAPT1 CCDC39 ARL6 DDX59 BBIP1 CFAP52 TTBK2 DNAI2 POMGNT1 TOPORS NME7 NME9 USP9X CEP83 EFHC1 ZMYND10 SMO KIZ C2CD3 CFAP53 KATNIP CCDC103 PKD2 TMEM107 DNAH6 MKKS PKD1L1 POC1A BBS10 POC1B PIK3R4 BBS12 RAB28 XPNPEP3 CILK1 DNAI1 TUB PCARE RPGRIP1 RAB23 RP1L1 SCLT1 TTLL5 CNGA1 CENPF SPAG1 HYLS1 ATXN10 TRIM32 DYNC2H1 DYNC2I2 PLK4 LZTFL1 DYNC2I1 CNGB1 IFT140 SPATA7 DYNLT2B WDR19 IFT122 IFT80 WDR35 DYNC2LI1 IFT43 IFT81 IFT27 PKD1 TULP1 GLI3 DRC1 IFT52 ZNF423 IFT57 IQCB1 DNAJB13 FLCN CCDC40 CEP120 CEP164 TCTN3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260910%WP3995%HOMO SAPIENS Prion disease pathway MAPK3 RXRA SPI1 STAT3 ELK1 EP300 SMC3 PDIA3 POU2F2 RFX5 BATF CASP3 BCL2 EBF1 RAD21 CREB1 FGFR1 FYN PAX5 PRNP IRF4 HSP90B1 NCAM1 HSPA5 BCL11A PTK2 CTCF MEF2C TBP CHD2 NFKB1 MAPK1 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260910%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis RPL11 MAPKAP1 MLST8 PTEN FOXO3 AKT2 AKT3 AKT1 TP53 MTOR EGFR RICTOR RIOK2 PIK3CA RIOK1 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260910%WP3877%HOMO SAPIENS MYD88 distinct input output pathway MYD88 TRAF6 IL1A TLR1 TLR9 TLR5 TLR8 TLR6 TLR2 TLR7 TLR10 TLR4 IRAK1 UBE2N JUN NFKB1 TIFA UBE2V1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260910%WP4172%HOMO SAPIENS PI3K Akt signaling CD19 PRKAA1 ATF2 IKBKB FGF21 JAK3 CHUK RHEB RELA PRKAA2 EGF FN1 EPO TNC CCND1 MYC KDR PDGFB PDGFRB FGF2 ATF4 KIT IGF1 EIF4E BCL2 CREB3L2 RAF1 AKT2 AKT3 AKT1 MTOR GSK3B TCL1B PIK3R2 TCL1A PIK3R1 PPP2R1B PPP2R1A DDIT4 PPP2R2A;PPP2R2D MAP2K2;MAP2K1 EPHA2 MAPK1 RAC1 LPAR2 JAK2 LPAR3 IL6R LPAR4 GNG10 PDGFD MAPK3 PDGFC JAK1 NGFR GNG13 SGK3;C8orf44-SGK3 COL1A1 COL1A2 LPAR5 BAD LPAR6 GYS2 GNGT1 GYS1 IKBKG OSMR IL6 PHLPP2 IGF1R RPS6KB1 TNXB GRB2 PHLPP1 SOS1 RELN BCL2L1 VEGFB OSM VEGFD KITLG FGF20 CHRM2 CSF3R FGF23 IL2 STK11 FGF22 IBSP IL4 TNN FGF17 TNR PDGFRA FGF19 F2R FLT4 COL4A2 TLR4 COL4A1 PTEN EIF4E1B COL4A4 COL4A6 FGF1 CSF1R FGF3 FGF4 SOS2 FGF5 EFNA4 EGFR FGF6 HSP90B1 FGF7 VTN FGF8 CHAD FGF9 EFNA1 EFNA3 EFNA2 FGF14 GNB2 PRKCA GNB1 RPS6KB2 GNB4 EFNA5 GNB3 IL7R FGF13 FGF12 FGF11 HSP90AB1 LAMC3 LAMC2 PIK3R3 LAMC1 PIK3R6 GHR PIK3R5 HSP90AA1 VWF PPP2R5B PPP2R5A PPP2R5D NGF COL6A2 IL3RA EIF4E2 CREB5 LAMA5 LAMA2 LAMA1 LAMA4 LAMA3 THBS2 THBS4 THBS3 ITGA2B GNG2 GNG5 FGF18 PPP2R3C PPP2R3B FGFR4 GNG4 GNG8 FGFR3 EIF4B FGFR2 ANGPT4 LAMB3 TLR2 FGF10 NOS3 FGFR1 LAMB2 LAMB1 FOXO3 PPP2R3A BCL2L11 PIK3CD EPOR PCK2 PIK3CB PPP2R2C G6PC1 PIK3CG PPP2R2B FASLG TEK PPP2R5E PPP2R5C NTRK2 PTK2 PIK3CA ITGA10 FLT1 ITGA11 ITGB1 PGF ITGB5 ITGB4 ITGB3 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 PKN3 PDPK1 ITGA3 ITGA2 PKN2 ITGA1 CDKN1A PKN1 CDKN1B ITGA8 G6PC2 BRCA1 G6PC3 ITGA7 NTF4 ITGA6 FLT3LG CASP9 ITGA5 CCND3 CCND2 ITGA9 COMP CREB1 COL9A1 CCNE2 COL9A3 COL9A2 CCNE1 IFNB1-4 TP53 GNB5 MDM2-2 IL3 IL7 LAMB4 CDK6 CDK4 CDK2 CHRM1 IRS1 BDNF INS;INS-IGF2 PPP2CB;PPP2CA IFNAR2 TSC2 FLT3 RBL2 IFNAR1 PRL IL2RG RPS6 IL4R PRLR NFKB1 EIF4EBP1 IL2RA IL2RB CSF3 NTRK1 HGF SGK1-1 CREB3L3 CREB3L4 CREB3L1 SYK PDGFA TGFA INSR ATF6B SPP1 MYB CSF1 VEGFA MCL1 LPAR1 IGF2 NRAS HRAS KRAS THEM4 COL6A1 COL6A3 COL6A6 COL6A5 PCK1 PIK3AP1 MET RPTOR COL4A3 COL4A5 NTF3 MLST8 COL2A1 CDC37 ANGPT2 TSC1 ANGPT1 THBS1 VEGFC CREB3 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260910%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY6 ADRB2 ADCY3 ADCY5 ADCY8 ADRA2C ADRA2B ADRA2A ADCY10 ADCY9 ADCY1 ADCY4 ADCY2 ADRB1 ADRA1D ADCY7 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CSRP2 CCND1 CDH1 MACROH2A1 CDK4 TULP3 MED1 CTNNB1 RB1 E2F1 CDK8 PMAIP1 JAG1 SOX4 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders BHMT ADK CSAD AHCY MAT1A MAT2B CTH MTR-1 GNMT CDO1 CBS;CBSL NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260910%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT8 PRMT7 NOS2 PRMT3 DDAH2 NOS1 NOS3 PRMT5 DDAH1 PRMT2 PRMT1 CARM1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation NDEL1 CDK5 DCTN3 PAFAH1B1 DCTN1 YWHAE YWHAB TH YWHAQ DCTN6 YWHAH DDC DCTN4 YWHAG DYNC1H1 YWHAZ DCTN5 DCTN2 PPP2CB;PPP2CA DISC1 DBH 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome TRIM74;TRIM73;TRIM50 TMEM270 GAPDH-1 DDX21 CTNNB1 RB1 CLDN4 CLDN5 CLDN3 DLD DLST MYC SNAP25 ULK1 CLTC ATF4 UBE2L6 EIF2AK3 HDAC6 VAMP2 HDAC2 MYBBP1A FAS SF3B1 ACACA RFC5 ACACB RFC2 OGDH BRD4 STX1A ATP5MC2 ATP5MC3 EIF2A ATP5MC1 ATP5F1A UBE2E1 ATP5F1B NUP62 HDAC3 MAPK3 PRKG1 BAZ1B ATP5PB MYO1C ATP5F1D ERCC6 ATP5PO SMARCA5 DEK CDKN1C GRB2 FBN1 USF1 BTK BECN1 CFL1 PKLR NRG1 SQSTM1 GRIP1 HSPA2 WNT2 EIF4H CLDN1 FZD9 CLASP1 ABHD11 LIMK1 GTF2I UBE2E3 CLIP2 DNAJC30 FKBP6 VPS28 UBIAD1 TSG101 ATPAF2-2 FBLN2 FBLN5 HOXC8 TBL2 GTF2IRD1 BCL7B PCNA BUD23 VPS9D1 VPS37C VPS37D VPS37A VPS37B LAT2 CHTF18 METTL27 ATPAF1 MVB12A CLASP2 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260910%WP2333%HOMO SAPIENS Trans sulfuration pathway GOT1-1 GCLM DNMT1 CSAD AHCY MAT2B CTH MTR-1 MPST CBS;CBSL GLUCURONIDATION%WIKIPATHWAYS_20260910%WP698%HOMO SAPIENS Glucuronidation PGM2 UGT2A1 PGM5 UGDH UGP2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PGM1 HK1 UGT1A1;UGT1A6 PGM3 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260910%WP5166%HOMO SAPIENS Glyoxylate metabolism ALDH4A1 LDHA SLC26A1 PXMP2 GOT2-1 HAO1 GRHPR HOGA1 DAO PRODH2 AGXT ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260910%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance SLC2A4 INSR ACSL1 MAPK8 CD36 PRKCZ TNF AKT1 MAFA TNFRSF1A SMPD3 ERN1 IRS1 RPS6KB1 EIF2AK2 IRS2 TRAF1 PIK3R1 CPT1B INS;INS-IGF2 PPP2CB;PPP2CA PDX1 PRKAG3 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260910%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells CD63 SPP1 SOD1 BIRC5 KDR CD81 SORBS2 ETS2 STAT3 PTEN TLR4 GATA4 HSPB1 IL6 EGFR MMP9 PDLIM5 EGF IGF1 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260910%WP3944%HOMO SAPIENS Serotonin and anxiety related events PLCD4 NLGN1 HTR2A FOS PPP3CA ARC PLEK GRIN2D CRHR1 PRKCB CRH HTR1A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260910%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases ASAH1 KDSR SGPP1 SPHK2 SPHK1 SGPP2 SPTLC1 DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260910%WP5053%HOMO SAPIENS Development of ureteric derived collecting system EYA1 BMP4 GRIP1 BMP2 SMO WNT11 ETV5 GDNF CELSR1 BMPER GPC3 CRIM1 RET GFRA1 BMP5 CTDNEP1 FRAS1 FREM1 FREM2 ITGA8 SMAD1 ANOS1-1 GLI1 CCND1 SIX1 SALL1 SIX2 RARG BMPR1A FST BMP7 BMPR2 GLI2 SHH GDF11 GLI3 HOXD11 DCN HOXA11 PAX2 RARA RARB TGFB2 ETV4 SPRY1 TGFB1 MYCN VANGL2 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260910%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GOT1-1 SLC2A1 PC ALDOA HK2 LDHA GAPDH-1 PGAM1 PKM PGK1 SLC2A2 ALDOC ENO1 HK1 PFKM HK3 SLC2A5 GCK ENO2 DLAT ENO3 MPC2 PFKP DLD FBP2 LDHAL6B TPI1 PCK1 SLC2A4 PFKL ALDOB LDHB PDHA1 FBP1 LDHA;LDHC MPC1 PKLR PGAM2 G6PC1 MDH2 MDH1 GOT2-1 GPI ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260910%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B PYCARD CASP1 NLRP3 RELA TRAF3 NFKB1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260910%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX15 GGT1 ALOX12 PLA2G5 LTC4S PLA2G6 PTGS1 DPEP1 JMJD7-PLA2G4B;PLA2G4B ALOX5 LTA4H PTGDS CBR1-1 PTGIS PTGES2 PLA2G4A ALOX15B PRXL2B ALOX5AP TBXAS1 PTGS2-2 PTGES RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260910%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2B ITPR2 CAMK2D CYP11A1 CAMK2A REN ATF2 CAMK2G AGT GNAQ PLCB2 CREB3L3 CREB3L4 CREB5 CALML6 CREB3L1 CALML3 CAMK1D CALML4 CAMK1G CYP11B1;CYP11B2 CREB3L2 CTSG CALM3;CALM1 ATF6B STAR ATF1 HSD3B1;HSD3B2 CMA1 CREB1 CAMK1 CAMK4 ATF4 ACE AGTR1 AGTR2 CREB3 CYP21A2 ITPR1 CALM1 CALM2 ITPR3 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260910%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma JAK2 JAK1 EREG BTC NRAS HRAS STAT3 TYK2 JAK3 RHEB KRAS GRB2 SOS1 EGF RAF1 TGFA RPTOR TSC2 PDK1 PTEN AKT2 AKT3 AKT1 MTOR TSC1 SOS2 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism SLC2A4 ACADM SOD2 STK11 ACLY NOS3 AKT2 PPARA MTTP HADHB-1 ESRRA APOB ESR1 PPARGC1B TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260910%WP3851%HOMO SAPIENS TLR4 signaling and tolerance MYD88 TRAF6 MAP3K7 IRF3 IKBKB RIPK1 IRAK3 IKBKG CHUK TICAM1 IL6 INPP5D TRAF3 NFKBIA CXCL8 TIRAP TRAM1 TLR4 TNF IFNB1-4 IRAK1 TBK1 IRF7 IRAK4 IKBKE NFKB1 TAB2 TAB1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260910%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1C CHRNB4 CHRNA3 CACNA1G RANKL RANK SIGNALING%WIKIPATHWAYS_20260910%WP2018%HOMO SAPIENS RANKL RANK signaling TRAF6 MAP3K7 MAPK9 MAPK3 STAT1 MAPK14 SPI1 IKBKB IKBKG CHUK GAB2 FOS CBL TNFSF11 RELA TRAF2 LYN SYK PAPSS2 NFKBIA MITF SRC CDC42 RELB SQSTM1 TAB2 TAB1 MAPK8 PLCG1 MAP2K7 TRAF5 TRAF1 MAP2K6 JUN TRAF3 TNFRSF11B TNFRSF11A NFATC1 AKT2 AKT1 MTOR PIK3R2 PIK3R1 PTK2 FHL2 MAP2K2;MAP2K1 NFKB1 MAPK1 NFKB2 RAC1 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260910%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism FMO3 CHDH ALDH7A1 SLC44A1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260910%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis DLL1 DLL3 EPHA4 MESP2 NOTCH1 LFNG TBX6 HES7 RIPPLY2 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260910%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria NDUFA9 DMAC2L ATP5PF UCP1 NDUFA8 NDUFA7 NDUFA6 ATP5PD NDUFA5 NDUFA4 ATP5PB NDUFA3 ATP5F1D NDUFAB1 ATP5PO NDUFS5-1 UQCRB NDUFA12 UQCR11 COX6A1 UQCR10 COX6A2 SDHC SDHD UQCRQ SDHA UQCRC1 UQCRFS1 SDHB SLC25A5 COX6B1 SLC25A6 UQCRC2 COX7A2 ATP5IF1 COX7B SLC25A14 COX4I1 SLC25A27 UCP3 COX7C UCP2 ATP5F1C COX8A COX7A2L-1 NDUFB3 COX5B COX5A COX6C SLC25A4 COX11 NDUFA11 NDUFA10 NDUFA13 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB10 NDUFB6 NDUFB5 COX17 NDUFB4 NDUFB2 ATP5MC2 NDUFB1 SCO1 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B NDUFC2;NDUFC2-KCTD14 NDUFV3 SURF1 NDUFV2 ATP5MG COX15 NDUFV1 ATP5ME DNA MISMATCH REPAIR%WIKIPATHWAYS_20260910%WP531%HOMO SAPIENS DNA mismatch repair RFC1 POLE2 RPA3 POLE3 POLD3 POLD4 POLD1 POLD2 LIG1 PMS2 PCNA EXO1 MSH6 RPA1 POLE RFC5 MSH2 RFC3 RFC4 RPA2 MLH1 RFC2 POLE4 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling RASA1 MAPK3 MAPK8 HRAS STAT3 ELK1 GAB1 PTPN11 MAP4K1 ITGA1 HGF FOS RAPGEF1 GRB2 PTGS2-2 JUN SOS1 CRK DOCK1 CRKL SRC RAF1 MET PAK1 PTEN PXN RAP1B RAP1A PTK2B PTK2 PIK3CA ITGB1 MAP2K2;MAP2K1 MAPK1 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260910%WP4537%HOMO SAPIENS Hippo YAP signaling CXCL10 MINK1 STK38L TNIK STK3 SAV1 YAP1-1 TEAD1 WWTR1 MAP4K3 TEAD3 MAP4K4 TEAD4 LATS2 MAP4K1 MAP4K2 MST1 NDRG1 LATS1 NF2 TEAD2 RASSF1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260910%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG16L1 ATG13 ZFYVE1 ATG16L2 PIK3R4 ULK2 ULK1 MTOR MAP1LC3A ATG3 RB1CC1 ATG10 WIPI1 ATG12-1 PIK3C3 BECN1 ATG4A ATG7 ATG5 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260910%WP272%HOMO SAPIENS Blood clotting cascade SERPINE1 SERPINB2 KLK1 PLAT F11 PLAU F10 VWF FGB FGA F13B FGG SERPINF2 F12 F2 F3 F7 F5 PLG F8 KLKB1 F9 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260910%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling CREBBP AR BAD CTNNB1 IKBKG CDKN1A CDKN1B KRAS GRB2 CASP9 FOXO1-1 CREB3L1 SOS1 NFKBIA BCL2 TCF7 PDGFA RAF1 CCND1 PDGFRB AKT3 TP53 MDM2-2 MTOR GSK3B PIK3CA MAP2K2;MAP2K1 KLK3;KLK2 NFKB1 MAPK1 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer MAP3K7 ATF3 MACROH2A2 WNT11 DKK1 HNRNPU SOST WNT7B PLAU TFAP2A CTNNB1 TPTEP2-CSNK1E;CSNK1E FRAT2 CSNK2A2 CCND3 SFRP4 CCND2 CSNK2B TCF7 DVL1 DVL2 FOSL1 HNRNPK CCND1 MYC DVL3 DKK2 DKK4 RUVBL1 FZD10 APC2 AXIN1 AXIN2 CSNK2A1;CSNK2A3 SOX17 CER1 LEF1 SERPINF1 CTNNBIP1 SFRP1 SFRP2 SFRP5 CTBP2 CTBP1 TCF7L2 PORCN TCF7L1 WNT5B CSNK1A1 RYK-1 APC KREMEN1 SENP2 ROR1 ROR2 CDK6 CXXC4 NKD1 NKD2 WIF1 NOTUM EZH2 WNT6 WNT1 WNT2 WNT4 WNT10B WNT10A FZD2 JUN FZD5 FZD7 FZD6 FZD9 FZD8 FZD1 FZD3 WNT3A WNT5A WNT7A CHD8 WNT2B WNT3 LRP6 GSK3B CDK8 WNT16 NLK LRP5 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B1 F13B HSD17B2 HSD17B3 CYP17A1 HSD3B1;HSD3B2 CPN1 HSD17B7 HSD17B4 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260910%WP5193%HOMO SAPIENS Cholesterol synthesis disorders SQLE HSD3B1;HSD3B2 IDI1 CYP51A1 EBP MVK SC5D DHCR24 MSMO1 DHCR7 LBR MVD HMGCR HMGCS1-1 PMVK FDFT1 FDPS LSS GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260910%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis IL2RA CCR6 ITGAV BLK SLC22A4 CIITA FCRL3 PTPN22 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PADI4 CD244 PHF19 CTLA4 IRF5 TRAF1 IL6ST CD40 STAT4 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260910%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2;SMAD3 GLI3 TGIF2 FGF8 FOXG1 NKX2-1 TGIF1-1 NODAL SHH LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260910%WP5314%HOMO SAPIENS Lactate shuttle in glial cells SLC2A1 LDHB LDHA NUDT14 SLC1A2 SLC4A4 CA2 HK1 CA4 SLC16A1 SLC16A7 SLC16A3 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260910%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits TNC VCAM1 NOTCH1 PIK3CG WNT2 LEF1 POSTN CYTIP CXCR4 VEGFA JAG1 TCF7L2 TCF7L1 VHL TCF7 EPAS1 SRC INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260910%WP5120%HOMO SAPIENS Inclusion body myositis NCSTN MSTN SIRT1 PSEN1 MAPT PSENEN APP BACE1 PSEN2 NFKB1 NFKB2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260910%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT1 SGMS1 SGPL1 B3GALT2 B3GALT1 GALNT1 SGPP2 SGMS2 CERS3 UGT8 UGCG KDSR CERK SGPP1 B4GALT2 SPHK2 B4GALNT1 B3GALNT1 SPHK1 GALNT16 ST6GALNAC3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260910%WP4630%HOMO SAPIENS Measles virus infection HSPA6 IRF3 MAPK9 MAVS IKBKB MAPK10 JAK3 CHUK CDKN1B FOS BBC3 RELA CASP9 EIF3H CCND3 CCND2 STAT5A STAT5B NFKBIA CASP3 CCND1 HSPA8 APAF1 CCNE2 CCNE1 IFNB1-4 TP53 CYCS-1 IRAK1 EIF2AK3 EIF2AK2 BID RCHY1 CLEC4M;CD209-2 TAB2 RAB9A NECTIN4 RAB9B MYD88 CDK6 IL1B CDK4 CDK2 MAPK8 SLAMF1 CASP8 FAS BAX TRADD FADD JUN BCL2 IFNAR2 STAT2 ADAR MX1-1 OAS1 IRF9 IFNAR1 IL2RG PIK3R2 PIK3R1 IRAK4 NFKB1 NFKB2 RACK1 TRAF6 CBLB MAP3K7 IL2RA IL2RB NFKBIB JAK1 STAT1 BAD CD3G STAT3 IL12B EIF2S1 CD3E TYK2 IKBKG IL6 CD3D CSNK2A2 CSNK2B BCL2L1 MSN IL2 IL1A OAS3 TLR9 IL12A TLR7 TLR4 CSNK2A1;CSNK2A3 EIF2AK1 EIF2AK4 IRF7 BAK1 CD28 HSPA2 PIK3R3 TRAF3 TNFAIP3 TLR2 PIK3CD PIK3CB TP73 HSPA1A;HSPA1B FASLG IFIH1 TBK1 PIK3CA HSPA1L IKBKE DDX58 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260910%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA VDR COPPER METABOLISM%WIKIPATHWAYS_20260910%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC11A2 SLC31A1 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260910%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IRF3 NFKBIE IL1B NLRX1 STING1 IFNB1-4 IKBKB CHUK IKBKG CGAS REL RELA NLRP3 F3 TBK1 ITPR1 NFKBIA NFKB1 IKBKE GSDMD FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260910%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins ARHGDIB NFX1 MAP3K7 MAPKAPK2 LMNA MAP2K4 PRKDC MAPK8 CASP8 FAS PARP1 FADD RB1 LMNB1 ACTG1 ACTA1 CASP9 JUN MAP3K1 CASP3 BCL2 DFFB DFFA PAK1 FAF1 APAF1 PAK2 IL1A RIPK2 CFLAR TNF ACTB-1 CYCS-1 HSPB1 FASLG DAXX CASP7 CASP6 CASP10 MAPKAPK3 LMNB2 SMIM40 SPTAN1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway DNAJC7 EHHADH-1 CYP2B6 NCOA1 RXRA CYP2A13;CYP2A6;CYP2A7-1 NCOA6 PPARGC1A ALAS1 HSP90AA1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 NR1I3 ABCC2 FOXO1-1 GSTA3;GSTA5;GSTA1;GSTA2 PTPA SMC1A SP1 NCOA2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2A1-4 ABCB1 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260910%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BCL2L12 MYC BCL2L13 BCL2L14 BCL2L15 BOK BCL2L10 BAX AKT2 BCL2A1 AKT3 AKT1 BCL2L2 PIK3CG GSK3B ITGA6 BAK1 BID GSK3A MCL1 BCL2L1 BCL2 ITGB4 PTHLH INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer CCL4L2;CCL4L1;CCL4 MYC BMI1 CD96 CSF2 PVR NCR1-1 PRF1 IFNG NCR3LG1-1 CCL5 CCL1 TNF CD226 GATA2 TIGIT CCL13;CCL2 ADAM17 FCGR3A;FCGR3B KLRC4-KLRK1;KLRK1 FOXO1-1 GZMH;GZMB-1 CCL3L1;CCL3L3;CCL3;CCL18 ADAM10 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260910%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response C3-1 ITGB2 SELPLG VCAM1 ITGAL KNG1 IL1A SELP C6 C7 ICAM1 ITGA4 TNF IL6 ITGB1 C5 CXCL8 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260910%WP4707%HOMO SAPIENS Aspirin and miRNAs MVD WNT1 ABCC4 PPARA PTGS1 PTGS2-2 VEGFA NOS3 PDK1 NFKB1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260910%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway PLPP2 SGMS1 DEGS2 ASAH1 CERS3 CERS5 CERS6 CERK CERS1 SPHK2 SPHK1 SGPL1 SGPP2 PLPP1 SPTLC1 SGMS2 UGT8 UGCG KDSR CERS4 SGPP1 DEGS1 CERS2 SMPD1 PLPP3 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260910%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GAPDH-1 GRM3 MBD5 SDCBP SLC6A8 ORAI1 HOMER1 SRC CACNG8 CACNG2 AP2A1 AP2A2 GRIN2A GRIN2C GRIN2B GRIN2D SLC32A1 GLUL AP2B1 SLC1A6 GLS2 GRIA3 GAD1 GRIA4 SLC1A3 FRMPD3 ABAT GRM5 ADARB1 GRIK5 ZFYVE27 GRIK3 CRTC1 SH3GL2 GRIK4 SLC6A12 GRIK1 SLC1A7 GRIK2 NETO2 CPEB3 GRM2 GRM4 NPTN GRM7 C1QL3 GRM8 C1QL2 PLCB1 NWD1 SNX27 UBQLN4 ATAD1 SYVN1 LHFPL4 SNX14 PPP2CB;PPP2CA NR4A1 SLC12A5 SLC6A1 CABIN1 GRIN1 GRM6 KIF5C GRIN3B GRIN3A HDAC1 GABRR3 GABRR2 GABRR1 MAP2K2;MAP2K1 MAPK1 SUMO1 MAPK3 CREBBP GNA11 STAT1 ERBB4 STAT3 P4HB CDH2 SLC7A11 SLC1A2 SLC6A6 SLC1A1 GABRB3 MAP1LC3B2;MAP1LC3B-1 GABRB2 GABRB1 GABRG3;GABRG2 NRG1 GABRE GABRD GABRQ GABRA2 PRKCA GABRA1 GRIP1 GABRP GABRA6 GRIA1 GABRA5 GABRA4 GABRA3 SLC6A11 GABRG1 CAMK2A EFNB2 NRXN3 GRIA2 GRM1 GNAQ ARC DLGAP3 PICK1 DLG4 FFAR1 PDIA2 HDAC10 STIM1 SLC6A13 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260910%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 MS4A1 C3-1 ITGB2 CD19 PDCD1 CD79A ITGAX ISG15 TNFSF13B LOC110384692;C4A;C4B_2;C4B IL6 CR2 PTPRC SYK STAT5A EBI3 IL10 HSPA8 SH2D1A IL2 IL4 IFNG CD40LG IL12A TLR7 TLR4 TNF CXCL13 CR1L;CR1 BCR XBP1 CXCR5 IFIT2 CCL19 CCL21 LOC102723996;ICOSLG BTLA ICOS IL21 CXCR4 FOXO1-1 CXCL12 ETS1 BACH2 BLNK CD40 PTCRA FCRL5 IFITM3;IFITM2;IFITM1 CD1D TBX21 SLAMF7 AICDA CD22 CCR7 IFNAR2 MAF CD69 PAX5 ZEB2 MFGE8 BCL6 CD80 TMSB10 CD82 IRF4 IRF8 CRP GPR183 PRDM1 SELL KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PCYT1B SGPL1 PTDSS1 CHKA PISD ETNK2 PTDSS2 CEPT1 ETNK1 CHKB PCYT2 PEMT CHPT1 PCYT1A ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP1541%HOMO SAPIENS Energy metabolism MEF2A MEF2B;BORCS8-MEF2B PPP3CA PPP3CB PRKAA1 NCOA1 PPP3CC RXRA MYBBP1A MAPK14 ATF2 PPARGC1A TFAM-1 EP300 PPARD CAMK2G MED1 SIRT1 PRKAA2 FOXO1-1 ESRRA PRKAG1 PRKAG2 PRKAG3 PPARGC1B UCP3 PRKAB2 UCP2 PRKAB1 MEF2D CREB1 NRF1 FOXO3 TFB2M CAMK4 TFB1M PPRC1 PPP3R1 GABPA PRMT1 SIRT3 PPARA GSK3B HDAC1 MEF2C PPARG NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260910%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 NMNAT1 QPRT HAAO KMO TDO2 KYNU AFMID BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260910%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GOT1-1 GATM GPT GLS2 ASL NAGS OTC GAMT F7 ARG1 F10 ASS1 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260910%WP4562%HOMO SAPIENS Canonical NF kB pathway CHUK IKBKG NFKBIE REL RELA NFKBIA NFKB1 IKBKB ATR SIGNALING%WIKIPATHWAYS_20260910%WP3875%HOMO SAPIENS ATR signaling TOPBP1 HUS1 RAD9B RPA3 RPA1 ATRIP RAD1 RPA2 ATR CHEK1 RAD9A NEUROINFLAMMATION%WIKIPATHWAYS_20260910%WP4919%HOMO SAPIENS Neuroinflammation MTOR CHUK NOS2 ASCC1 FOS RELA MAPK8 JUN MAPK14 NFKBIA TLR4 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260910%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling PRKCA RASA1 RASGRP1 PPP3CA PDCD1 PLCG1 NFATC2 ITK DYRK1A NFKBIA PTPN6 LCK IL2 CD8A DYRK2 CD8B;CD8B2 FYN PDK1 PTEN AKT1 CTLA4 GSK3B GSK3A CD28 ZAP70 CSNK1A1 NFKB1 CALM1 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260910%WP5195%HOMO SAPIENS Disorders in ketolysis HMGCS1-1 BDH1 OXCT1-1 ACAT1 ACAT2 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260910%WP4540%HOMO SAPIENS Hippo signaling regulation CDH5 CDH4 CDH3 CDH20 CDH22 PRKAA1 CDH24 NGFR CDH10 GNA11 CDH11 CDH12 NTRK1 PRKCD CDH13 CDH15 CDH17 CDH18 LATS2 CDH19 CTNNB1 CDH6 CDH2 IGF1R CDH16 PRKAA2 PRKAG1 PRKAG2 PRKAG3 TCF7 PRKACB-1 CDC42 PRKAR2B PRKAR2A PRKAB2 INSR PRKAB1 PRKAR1B KDR PRKAR1A PDGFRA GNAI3 FLT4 GNAI2 PDGFRB CSF1R LEF1 EGFR KIT PRKCG PRKCI TCF7L2 PRKCH TCF7L1 PRKCB PRKCE PRKCA PRKCQ STK3 YAP1-1 TEAD1 PRKCZ PLCB3 WWTR1 TEAD3 PLCB4 TEAD4 RHOA GNAS-1 GNAQ MST1 PLCB1 LATS1 PLCB2 NF2 TEAD2 MET SMAD2;SMAD3 CDH1 GNAL FGFR4 PRKACA-1 FGFR3 PRKD3 FGFR2 FLT3 FGFR1 MTOR TEK NTRK2 CDH8 FLT1 CDH9 EPHA2 CDH7 RAC1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260910%WP129%HOMO SAPIENS Matrix metalloproteinases TIMP4 MMP1 MMP21 MMP20 MMP25 MMP24 MMP27 MMP2 MMP28 MMP9 MMP7 MMP3 MMP8 MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 TCF20 TIMP1 MMP15 MMP23B TIMP2 MMP17 TIMP3 MMP19 TNF BSG KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260910%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy VAMP2 FGF13 FGF12 ANK3 CAMK2A BACE1 SCN4B KCNQ2 KCNQ3 NEDD4 PRRT2 DAG1 AKAP5 KCNQ1 PRKACA-1 RAB1A SNAP25 TRAPPC3 SCN2A TRAPPC2;TRAPPC2B SCN8A GIGYF1 TRAPPC6B KCNQ4 KCNQ5 STX1A NEDD4L ITPR1 RAB11A CALM1 PRKCE LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP5171%HOMO SAPIENS Leukotriene metabolic pathway GGT1 LTC4S DPEP1 PTGR1-1 ALOX5 LTA4H DPEP2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DECR2 GGT5 ALOX5AP DECR1 ABCC1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis SRD5A2 AKR1D1 HSD11B1 HSD11B2 CYP21A2 CBR1-1 CYP11B1;CYP11B2 SRD5A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BENZENE METABOLISM%WIKIPATHWAYS_20260910%WP3891%HOMO SAPIENS Benzene metabolism DHDH NQO1 CYP2E1 MPO GSTM1;GSTM2-1 EPHX1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260910%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis COL3A1 COL1A1 YAP1-1 TEAD1 BCAR1 SPARC TEAD3 TEAD4 GPC6 SNAI2 PBX3 TEAD2 EDNRA COL5A1 FN1 THBS2 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260910%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP27B1 NR1H3 CYP7A1 CYP2B6 CYP4B1 VDR CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PPARD ABCC3 ABCD3 CYP26A1 ABCB4 NR1I3 ABCC2 CYP8B1 NR1I2 NR1H4 ABCB11 CYP24A1 ABCG1 ABCA1 ABCG5 RARG CYP2C9;CYP2C19 ABCD2 RARA PPARA RARB CYP2E1 PPARG ABCB1 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260910%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP19A1 SRD5A2 HSD17B2 HSD17B3 CYP17A1 HSD3B1;HSD3B2 CYP11A1 SRD5A1 UGT1A1;UGT1A6 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP581%HOMO SAPIENS EPO receptor signaling JAK2 RASA1 MAPK3 STAT1 STAT3 IRS1 PTPRC IRS2 GRB2 SOS1 STAT5A STAT5B SHC1-1 SRC EPO RAF1 PDK1 EPOR AKT1 PIK3CG PTPRU SOCS1 CISH MAP2K2;MAP2K1 MAPK1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4224%HOMO SAPIENS Purine metabolism and related disorders DGUOK ITPA TPMT MAT2A ADA GRM5 PRPS1 ATIC RRM2B ADSL PAICS IMPDH1 HPRT1 MOCOS ADSS2 GART PFAS PPAT XDH PNP-1 AMPD1 APRT AOX1 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation ITGB3 CSF3 CSF2 TPO SPI1 VAV1 KLF1 FOS IL6 TNXB KCNH2 RHOH STAT5A EPO KITLG RUNX1 GP9 IL1A CIITA IL5 GATA2 MYB IL3 CSF1 LEF1 ACVR1B CD34 HES6 IL1B NOTCH1 NFATC2 CXCR4 MUC1 THRB LYL1 ITGA2B IRF5 TRAF3IP3 IKZF1 FOSB HMGN5 LMO2 TRIM29 PIM1 GATA1 SEC14L2 NCKAP1L MXI1 NFE2 RIOK3 FLI1 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260910%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK3 EGFR JAK1 STAT3 MAPK1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260910%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260910%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways ITPR2 ADCY8 ETS2 ATF2 MAFF ACTG1 FOS GJA1 ATF5 RYR1 PRKACB-1 PRKAR2B PRKAR2A CACNB3 PRKAR1B PRKAR1A CREB1 CRHR1 ATF4 YWHAE GNB5 YWHAB ACTB-1 YWHAQ GABPA YWHAH ACTA2 ADCY1 SFN CALM1 CALM2 RYR3 IL1B PLCB3 ADM JUN RGS1 CALM3;CALM1 RGS2 NOS1 GABPB1 GRK6 YWHAG YWHAZ ITPR1 NFKB1 ITPR3 CRH CRCP RXFP2 RGS4 ATF3 RGS5 RGS3 RGS6 RGS7 IGFBP4 GNG13 CNN2 PLCG2 GRK5 GRK4 PRKCD CALD1 IGFBP6 PKIB PKIA GPR182 GNGT1 PKIG RGS18 PLCD1 ARRB1 RGS17 RLN2;RLN1 ATP2A3 ARRB2 RAMP2 CNN1 IL6 ATP2A2 RGS19 RAMP3 RGS14 RAMP1 RGS16 RGS20 CORIN GUCA2B RGS10 ADCY4 GUCA2A CALCA ADCY2 RGS11 RGS9 ADCY7 ADCY6 ATF6B PDE4B ADCY5 PDE4D-1 OXT-1 SP1 SLC8A1 ADCY9 GSTO1 IGFBP1 IGFBP3 OXTR PRKCG PRKCH PRKCB MYL4 MYL2 GNB2 PRKCE PRKCA GNB1 LPAR1 GNB4 GNB3 ADCY3 PRKCQ CAMK2B PRKD1 RYR2 ACTC1;ACTG2 CAMK2D PLCG1 CAMK2A PRKCZ RXFP1 IGFBP5 CAMK2G GNAS-1 GNAQ ACTA1 GUCY1A1 ACKR3-2 MYLK2 GNG2 GNG5 ATF1 GNG4 PRKACA-1 GNG8 NOS3 DGKZ IGFBP2 CREB3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP453%HOMO SAPIENS Inflammatory response pathway IL2RA IL2RB COL1A1 COL1A2 LAMC2 LAMC1 TNFRSF1A IL5RA LAMA5 CD40 FN1 THBS3 COL3A1 LCK IL2 TNFRSF1B IL4 IFNG CD40LG LAMB2 LAMB1 IL5 CD86 CD80 IL2RG THBS1 VTN IL4R CD28 ZAP70 CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260910%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer CYP19A1 CDK6 MAPK3 CDK4 CDK2 NRAS PIK3R4 PIK3R3 HRAS PIK3R6 PIK3R5 CDKN1A CDKN1B IRS1 IGF1R KRAS INS;INS-IGF2 ESR1 RAF1 CCND1 RPTOR ERBB2 PIK3CD AKT2 CCNE1 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A MTOR PIK3CG PIK3C2B EGFR PIK3R2 PIK3R1 PIK3CA MAPK1 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260910%WP2261%HOMO SAPIENS Glioblastoma signaling MAPK3 MAP2K4 PLCG2 ERBB3 PRKCD GAB1 PDPK1 EP300 RB1 CDKN1A CDKN1B IGF1R BRCA1 CBL GRB2 CCND2 ERRFI1 FOXO4 SRC CCND1 ERBB2 PDGFRA PDGFRB PTEN CDKN2B BRCA2 CCNE1 CDKN2C TP53 MDM2-2 EGFR E2F1 MSH6 PRKCG PRKCI PRKCH PRKCB PRKCA CDK6 PRKCQ CDK4 CDK2 NRAS PLCG1 HRAS PRKCZ SPRY2 ATM NF1 MDM4 MAP2K7 IRS1 KRAS MAP2K6 MAP2K3 FOXO1-1 RAF1 MET ARAF FGFR2 TSC2 FGFR1 FOXO3 PIK3CD AKT2 PIK3C2G AKT3 PIK3CB AKT1 PIK3C2A PIK3CG TSC1 PIK3C2B MAP2K5 CDKN2A PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2876%HOMO SAPIENS Pregnane X receptor pathway DNAJC7 CYP2B6 NCOA1 RXRA CYP2A13;CYP2A6;CYP2A7-1 PPARGC1A HSP90AA1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ABCC4 ABCC2 NR1I2 FOXO1-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SRPX2 SRC GSTA3;GSTA5;GSTA1;GSTA2 NRIP1 PSMC5 NCOA2 CYP2C9;CYP2C19 UGT1A1;UGT1A6 NCOA3 SULT2A1-4 ABCB1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260910%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL3 MYH6 DMD DES TNNI3 ACTC1;ACTG2 TPM4 TPM2 ACTG1 TPM3 ACTA1 ACTN2 ACTN3 MYOM1 TNNI1 ACTN4 TNNI2 MYBPC3 MYBPC1 MYBPC2 TNNC2 NEB MYH3 VIM TNNT1 TNNT3 MYH8 TMOD1 TPM1 ACTA2 TNNC1 TTN-1 TCAP TNNT2 MYL4 MYL2 MYL1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXTL3 CSGALNACT1 B3GAT3 SLC35B3 B3GALT6 SLC35B2 EXT1 CHST14 CANT1 EXT2 BPNT2-1 CHSY1-1 B4GALT7 SLC26A2 XYLT2 XYLT1 PAPSS2 CHST3 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260910%WP5294%HOMO SAPIENS Sildenafil treatment NOS2 PDE4B PDE4A PDE4D-1 GAPDH-1 NOS1 PRKG1 NOS3 PDE5A NRF1 PPARGC1A GUCY1B1 AKT2 PRKN AKT3 ZNF746 TFAM-1 AKT1 GUCY1A2 GSK3B GUCY1A1 PDE4C SICKLE CELL DISEASE%WIKIPATHWAYS_20260910%WP5604%HOMO SAPIENS Sickle cell disease IL18 IL1B HBA2;HBA1 HBD;HBB TLR4 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260910%WP2855%HOMO SAPIENS Dopaminergic neurogenesis STAT3 RET WNT1 CDKN1C SOX2 ALDH1A1 OTX2 GLI1 NR4A2 MSX1 FOXA2 SLC6A3 NEUROD1 EN1 GBX2 LMX1B NEUROG2 ASCL1 GLI2 SHH PITX3 TH NKX6-1 EN2 LMX1A SLC18A2 DDC NKX2-2 FGF8 TGFB1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260910%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 APAF1 CASP8 FAS MAPK10 RIPK1 FADD CYCS-1 TNFRSF1A HSPA1A;HSPA1B FASLG CASP7 CASP9 CASP6 CASP2 BID MAP3K1 AIFM1 NFKB1 CASP3 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260910%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways PGM2 HK2 LDHA GAPDH-1 CEP290 SDS PKM PGK1 CREBBP ALDOC ENO1 HK1 CDH13 PFKM STAT3 HK3 BAP1 EP300 ENO2 RHEB ENO3 PFKP SHMT2 GRB10 VHL LDHB SSPN LDHA;LDHC ACLY KDR PDGFRA PDGFB BHLHE41 PDGFRB CAMK1 PTEN PKLR KDM5C EFCAB3 PLOD2 ENPP3 EGFR PBRM1 TOX2 RAPGEF5 VEGFA SDSL PGBD5 LDHD SQSTM1 KCNJ2 GPI SLC2A1 DEPTOR ALDOA SHMT1 PHGDH HIF1A PGM1 ZEB1 PSPH PSAT1 ACACA ACACB FASN TPI1 ME1 PFKL ALDOB RPTOR TSC2 MLST8 AKT1 MTOR TSC1 MAP2K5 KSR1 MDH1 FLT1 ARNT AKT1S1 SETD2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260910%WP4571%HOMO SAPIENS Urea cycle and related diseases CPS1 GLS2 ASL NAGS SLC25A13 OTC SLC25A15 ARG1 ASS1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260910%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2;SMAD3 NEDD4 ATG16L1 TGFBR1-1 PMEPA1 LDLRAD4 TGFBR2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5380%HOMO SAPIENS 5q35 copy number variation MAPK9 TPM2 MAPK10 UIMC1 ABRAXAS1 BRCC3 BRCA1 PNPLA2 MAGED1 INPP5D ABHD5 SRC MAX MYC GNAI3 GNAI2 ABL1 BARD1 GRIN2B NTN1 H3-3A MAPK8 KDM6B JUN TMED10 GRIN1 DRD2 PTPN2 TMED2-1 GRK6 PIK3R1 PDLIM7 GAB1 HK3 COX6A1 IGF1R RGS14 GRB2 SOS1 COX6B1 COX7B COX4I1 SNCA COX7C SLC34A1 COX8A FGF19 COX5B COX5A EIF4E1B COX6C B4GALT7 FGF1 NELFB FBXW7 ADAM10 KIAA1191 ARL10 RNF44 UNC5A MYO7B HIC2 GPRIN1 CYP7A1 GNAI1 DOK3 PFN3 PRELID1 PLCG1 PTPRN2 NOP16 HIGD2A MXD3 PRR7 HIP1 FAF2 DDX41 BABAM1 BABAM2 TMED9 CLTB ARFGAP2 CDHR2 FAM193B CDHR5 CXCR4 F12 DBN1 LMAN2 RAB24 ZNF346 SNCB HIP1R SIMC1 TSPAN17 NSD1 ANKS4B FGFR4 EED CAPN3 FRS2 PTH USH1C COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260910%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome PDS5B PDS5A WAPL CDK1 PPP2R5B REC8 PPP2R5A SMC3 PPP2R5D AURKB PPP2CB;PPP2CA CDCA5 ESCO1 ESCO2 SGO1 PTPA SMC1A MAU2 RAD21 PLK1 SGO2 STAG2 HDAC8 PTTG1;PTTG2 PPP2R5E SMC1B PPP2R5C ESPL1 NIPBL PPP2R1B PPP2R1A STAG3 APC CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK9 MAPK3 MAPK8 MAPK14 MAPK12 MAPK13 MAPK10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAPK11 FAAH DAGLA CYP1A1 CNR1 PRKACB-1 ADCY7 PRKAR2B PRKACA-1 PRKAR1B NAPEPLD PRKAR1A DAGLB CYP2C9;CYP2C19 ADORA2A CNR2 AHR ADCY1 MAPK1 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation DLL1 RIMBP2 GATA6 HES3 ROBO1 SLC6A5 ITGA6 HOMER1 TNC HNF4A CNP SNAP25 CACNG2 AP2A1 HTR1A AP2A2 MBP SOX9 PAX3 SOX17 PAX6 SLC18A3 CD34 MOG CLDN11 UNC13A GRIN2B PECAM1 SYP OLIG2 SOX10 BMP4 GLUL TPH1 GAD1 SLC1A3 GAD2 SLC6A9 LHX1 SLC17A6 SLC17A7 SOX2 TUBB3;TUBB6 MSX2 ESRRB ACHE NR4A2 NEFL SLC6A1 FOXA2 CDH1 SLC6A2 SLC6A3 GRIN1 SLC6A4 FOXD3 SHANK3 TH CHAT NLGN1 KLF4 DPPA3 NGFR FABP7 NEFM GATA4 KCNJ6 CDH2 SNAI1 SNAI2 SLC1A2 MSX1 FEV GFAP ADRA2C HTR5A ADRA2B ADRA2A MAP2 FGF4 LEF1 TPM1 HES1 GPHN HES5 ZFP42 GABBR2 POU5F1;POU5F1B ALDH1L1 GABBR1 TBXT GLS CASK NOTCH1 NANOG;NANOGP8 MIXL1 NODAL DLG1 DLG2 SHANK1 DLG4 DCX LMX1B RIMS2 PPFIA1 HOMER3 BSN RBFOX3 FBXO15 TBR1 TWIST2 LIN7A FUT4 HOMER2 EVX1 DLG3 CD24 NES PCLO CSPG4 ERC1 DPPA2 ERAS GLRA1 ITGB1 GLRA2 AQP4 GLRA3 GLRB KRT15 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260910%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone CASR GABBR1 GPRC5B GPRC5A GPRC5D GPRC5C GRM3 GRM6 GRM5 GRM1 GRM2 GRM4 GRM7 GRM8 GABBR2 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260910%WP500%HOMO SAPIENS Glycogen synthesis and degradation HK2 PYGB GBE1 UGP2 PYGM PYGL PHKG1 HK1 GYG2 PGM1 PHKB PHKA1 GYS2 HK3 HKDC1 AGL-1 GYS1 PPP2R5B PPP2R5A PPP2R5D PPP2CB;PPP2CA CALM3;CALM1 PPP2R3B PTPA PPP2R3A PPP2R2C PHKG2 PPP2R2B PPP2R5E GYG1 PPP2R5C GSK3B GSK3A PPP2R1B PPP2R1A PHKA2 CALM1 PPP2R2A;PPP2R2D CALM2 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260910%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy SLC2A1 LDHA GAPDH-1 GPD1 HIF1A CD36 GPAT3 PPARG TPI1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260910%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection PRKCA TUBA1C NCK2 EZR TUBA1A WAS LY96 CD14 TUBA3E;TUBA3C-1 CTTN ARPC5L TUBB4A;TUBB;TUBB8B;TUBB8 ARPC1A CTNNB1 ARPC4 RHOA KRT18 TUBA8 ACTG1 ARPC2 ARPC3 ARHGEF2 TUBB3;TUBB6 TUBB2B;TUBB2A ARPC5 CLDN1 NCK1 ROCK1 TUBAL3 ROCK2 CDC42 TUBB4B CDH1 NCL-1 TLR5 ARPC1B FYN TLR4 TUBB1 HCLS1 YWHAQ ACTB-1 TUBA4A ABL1 OCLN-1 YWHAZ ITGB1 WASL COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260910%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C3-1 C8A ACE2 C3AR1 FCN2;FCN1 COLEC11 C5AR1 C6 C7 C9 MASP2 C5 CHOLESTASIS%WIKIPATHWAYS_20260910%WP5238%HOMO SAPIENS Cholestasis TJP2 SCARB1 RXRA EPHX1 ABCC3 HMGCR SLCO1A2 ABCC4 SLC10A1 ABCB4 ABCC2 ATP8B1 NR1I3 SLC22A1 NR1H4 ABCB11 ABCG8 LDLR ABCG5 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome DUSP14 TEC DHRS11 SLC35G4;SLC35G5;SLC35G3;SLC35G6 CWC25 SLFN11;SLFN13 AATF CCL3L1;CCL3L3;CCL3;CCL18 IKZF3 CISD3 RDM1 CCL11 LASP1 ARL5C C17orf98 CACNB1 C17orf50 CCL4L2;CCL4L1;CCL4 GPR179 UNC45B ERBB2 DDX52 LYZL6-1 MRPL45 PPP1R1B SRCIN1 RAD51D SLFN14 ZNF830 CCL14 CCL1 STARD3 SLFN5 GGNBP2 CCL8 TMEM132E FBXO47 MLLT6 HNF1B FBXL20 CCT6B NEUROD2 MIEN1 ZNHIT3 PNMT C17orf78 RFFL LIG3 ASIC2 SOCS7 GAS2L2 CCL16 HEATR9 TAF15 TCAP RASL10B SYNRG PCGF2 EPOP PEX12 AP2B1 MYO19 FNDC8 PLXDC1 GRB7 NLE1 ARHGAP23 TADA2A STAC2 RPL23 SLFN12L;SLFN12-1 CDK12 LHX1 MED1 PGAP3 MMP28 PIGW ACACA CCL23;CCL15 CCL5 CCL13;CCL2 PIP4K2B MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 GPHN MTARC2 XDH MOCS1 AOX1 VOLTAGE GATED SODIUM CHANNEL ACTION POTENTIAL%WIKIPATHWAYS_20260910%WP5594%HOMO SAPIENS Voltage gated sodium channel action potential PRKCA PRKACA-1 AKAP7 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260910%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria H3-3A HDAC2 SUV39H1 MTA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MTA3 CBX1 CHD4 CHD3 TP53 RB1 SREBF1 LEF1 E2F1 HDAC1 CBX3-1 INPP5K MTA2 MBD3 MBD2 RBBP7 RBBP4 KDM1A CBX5 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260910%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF3 TNFRSF11A IFIH1 MAVS IRF7 TLR8 TLR7 MR1 TLR3 DDX58 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260910%WP5355%HOMO SAPIENS Metabolic epileptic disorders GATM PC HLCS CPS1 HK2 LDHA ASL GAPDH-1 ECHS1 PKM OTC PGK1 ALDOC ENO1 HK1 PFKM ACAT1 HK3 SLC2A5 CBS;CBSL GCDH ENO2 ENO3 MPC2 PFKP DLD FBP2 SHMT2 LDHAL6B SLC25A5 SLC25A1 GPT DHTKD1 LDHB PDHA1 LDHA;LDHC MPC1 CTH PKLR MDH2 GOT2-1 AADAT GPHN ALDH7A1 XDH SLC25A15 GPI GOT1-1 SLC2A1 HADH ALDOA SLC1A5 GLS2 SHMT1 PGAM1 PHGDH MOCS2 SLC2A2 MOCS1 PSPH CDO1 MOCS3 AMT AASS SQOR SLC7A2 SUOX ETHE1 SPCS1 GCK GLUD1;GLUD2 DLAT GLDC PSAT1 TPI1 PCK1 SLC2A4 PFKL ALDOB ACO1 FBP1 SFXN1 PGAM2 G6PC1 MDH1 GAMT ARG1 BTD ASS1 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260910%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway NRP1 ACE2 TMPRSS2 TMPRSS4 FURIN SCARB1 TLR7 CTSV;CTSL SLC6A19 ACAT1 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260910%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds DVL2 TCF4 FZD8 FZD1 TNKS CTNNB1 WNT1 AXIN1 MBOAT1 LEF1 DKK3 GSK3B SFRP4 LRP1 FZD7 CSNK1A1 APC MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAPK3 MAPK7 PRKG1 MAP2K4 MAPK4 MAPK14 STAT3 IKBKB PDPK1 GATA4 AGT CTNNB1 IKBKG CHUK EDN1 IGF1R IL6ST EGF ROCK1 ROCK2 DVL1 MYLK FGF2 TNF HDAC4 HDAC5 HDAC9 HDAC7 MYLK3 LIF NRG1 IGF1 NFATC4 CDK9 CALM1 PRKCB TAB1 MAP3K14 PPP3CA PPP3CB PLA2G2A-1 CAMK2D CTF1 MAPK8 PIK3R3 CDK7 NPPA RHOA PLCB2 MAP2K7 MAP2K6 MAP2K3 EIF2B5 FZD2 RAF1 FZD1 NPPB WNT3A WNT5A FGFR2 LRP6 PIK3CD AKT2 PIK3CB AKT1 MTOR PIK3CG MYEF2 MAP2K5 GSK3B CISH PIK3R2 PIK3CA PIK3R1 TGFB1 RCAN1 IKBKE LRP5 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260910%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation FGB FGA F13B FGG F13A1 F2 PLG IL26 SIGNALING%WIKIPATHWAYS_20260910%WP5347%HOMO SAPIENS IL26 signaling JAK2 MAPK9 IL1B MAPK3 JAK1 EPHA3 CSF2 MAPK8 STAT1 MPO MAPK14 BAX ICAM1 STAT3 TYK2 MMP1 DEFB4A;DEFB4B IL20RA IL6 DCSTAMP RELA TNFSF11 RORC JUN MMP9 NFKBIA DDIT3 CASP3 IL10 CXCL8 SMAD2;SMAD3 NFATC1 IL26 ATP6V0D2 TNF IL33 CCL20 AKT1 IL10RB ACTA2 PIK3CA SOCS3 MAPK1 IL17A CTSK SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260910%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT4A1 SULT2B1 G6PD SULT1B1-1 PAPSS1 SULT6B1 GSR SULT2A1-4 SULT1C3 PAPSS2 SULT1C2 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260910%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2-2 LEPTIN SIGNALING%WIKIPATHWAYS_20260910%WP2034%HOMO SAPIENS Leptin signaling JAK2 SOCS2 EIF4EBP1 PTPN1 MAPK3 JAK1 NCOA1 PRKAA1 PLCG2 STAT1 BAD MAPK14 STAT3 ELK1 IKBKB PTPN11 LEP IKBKG CHUK RPS6KB1 RELA GRB2 PRKAA2 SOS1 STAT5B SHC1-1 ROCK1 ROCK2 ESR1 SRC CDC42 PDE3B ERBB2 SP1 CREB1 PTEN KHDRBS1 SOCS7 GSK3A MAPK8 PLCG1 HRAS RHOA RPS6KA1 IRS1 EIF4E LEPR FOXO1-1 KPNA4-1 ACACA ACACB CFL2 RAF1 NOS3 SH2B1 FYN AKT1 MTOR REL GSK3B CISH RPS6 PIK3R2 PIK3R1 PTK2 SOCS3 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260910%WP4315%HOMO SAPIENS Malate aspartate shuttle MDH1 GOT2-1 SLC1A3 SLC25A11 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260910%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYB5A STAR SRD5A2 HSD17B3 CYP17A1 POR HSD3B1;HSD3B2 CYP11A1 HSD17B6 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260910%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling JAK2 IL6R IL2RA MAPK9 IL2RB MAPK3 F2RL3 JAK1 MAPK7 MAPK6 CREBBP MAPK4 MAPK14 STAT3 MAPK12 MAPK13 MAPK10 TYK2 MAPK11 JAK3 IL20RA OSMR IL20RB CNTFR PTPRC IL27RA IL5RA IL6ST CSF2RB IFNLR1 SRC IL22RA1 CSF3R PDGFRA MAPKAP1 F2R PDGFRB CSF2RA IL10RB EGFR RICTOR MPL PRKCB DEPTOR IL7R IL9R CTF1 MAPK8 IL11RA GHR DUSP2 IL3RA PTPRT MAPK15 PTPRD SETD7 STMN1 IL21R RPTOR IL12RB2 IFNGR1 IFNAR2 TRIM28 IFNGR2 MLST8 MTOR F2RL2 LIFR IFNAR1 AGTR1 IL2RG AGTR2 PIAS3 AKT1S1 SOCS3 IL10RA MAPK1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260910%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators IFNK CCL27 IL19 CCL26 IL36A IL36B XCL1;XCL2 EBI3 IL36G AREG EPO IL1F10 IL20 PF4;PF4V1-1 IL26 IL27 CNTF CCL14 CCL1 TNF IL11 CCL8 IL33 CXCL13 IFNB1-4 CCL20 IL15 CCL25 IL3 CCL24 IL31 IL7 IL37 LIF CCL19 CCL16 CXCL2;CXCL3;CXCL1-1 CCL21 CXCL11 IL36RN IL1B CCL17 CCL22 LTA CX3CL1 CCL23;CCL15 MMP3 CCL5 TSLP CCL13;CCL2 IL17D TGFB1 IL17C IL17B NFKB1 CXCL10 CSF3 CSF2 IL12B MMP1 TNFSF13B IL6 IL13 CCL28 MMP9 CCL3L1;CCL3L3;CCL3;CCL18 IFNL2;IFNL3;IFNL1 IL10 OSM CCL11 CXCL8 IL18 CCL4L2;CCL4L1;CCL4 IL2 IL9 IL4 SPP1 IL1A IFNG IL12A IL5 CXCL14 CXCL9 CSF1 CXCL17 VEGFA IL17F PPBP IL17A IL24 CTF1 IL1RN IL21 IL22 CXCL12 IL25 IL23A CXCL5;CXCL6 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260910%WP3878%HOMO SAPIENS ATM signaling in development and disease RAD50 NHEJ1 CDK5 RNF168-1 CDK2 RNF8 PRKDC MAPK14 ATF2 MAPK12 MAPK13 ATM ATR MDC1 MAPK11 TP53BP1 IKBKG MRE11 G6PD PPM1D RBBP8 AURKB CHEK2 PPP2CB;PPP2CA RNF20 ATMIN-1 CHEK1 RNF40 CEP63 NBN STK11 SMC1A TRIM28 CDC25A TSC2 HDAC4 DCLRE1C TP53 MTOR HSPB1 PPP5C HMGN1 BUB1 LMNB2 NFKB1 RIF1 KAT5 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260910%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRG RARA RARB RARG RXRA RXRB IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260910%WP5172%HOMO SAPIENS Iron metabolism disorders CYBRD1 HEPH TFR2 FTL-1 TFRC HFE SLC11A2 TF SLC40A1 FTH1 BCS1L HJV STEAP3 HAMP CP UQCRFS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260910%WP408%HOMO SAPIENS Oxidative stress response TXNRD2 JUNB TXNRD1 MAPK14 MAPK10 FOS CYP1A1 GPX1 GSR GSTT2B;GSTT2 TXN2 GCLC NFIX SOD2 SOD3 NOX3 HMOX1 NQO1 SOD1 NOX5 SP1 UGT1A1;UGT1A6 NFE2L2 CYBB MAOA CAT XDH NOX4 NFKB1 MGST1 NOX1 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260910%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling JAK2 EIF4EBP1 MAPK9 TEC IL7R MAPK3 JAK1 MAPK8 STAT1 MAPK14 STAT3 YES1 PTPN11 GAB2 HCK RELA LYN STAT5A STAT5B NFKBIA BTK FES SRC STAT4 LCK FYN TSLP AKT1 CRLF2 STAT6 RELB RPS6 MAP2K2;MAP2K1 NFKB1 MAPK1 NFKB2 DRAVET SYNDROME%WIKIPATHWAYS_20260910%WP5200%HOMO SAPIENS Dravet syndrome PRKCA FGF13 STXBP1 SCN3B SCN3A SCN1B CAMK2A SCN4B SCN2B MAPK11 PRR5 PRR5L HCN1 SCN1A KCNA2 PCDH19 MAPKAP1 SCN2A MLST8 SCN8A TNF AKT1 SNTA1 MTOR RICTOR PIK3CA CHD2 NFKB1 CALM1 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260910%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL1B CSF2 IL12B IL6 LGALS3 LGALS1 IL13 CCL28 CXCL12 MMP9 VEGFB IL10 IL25 VEGFD CXCL8 IL2 LGALS9C;LGALS9;LGALS9B IL4 IFNG IL23A CCL5 REG4 IL12A TNF IL5 CCL20 CCL13;CCL2 VEGFC TGFB2 VEGFA IL17D TGFB1 CXCL2;CXCL3;CXCL1-1 IL17C TGFB3 IL17F CXCL5;CXCL6 IL17B IL17A PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260910%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 BIRC3 CASP8 RIPK3 BAX TRADD TNF RIPK1 FADD CYCS-1 TNFRSF1A CASP7 TRAF2 CASP9 PPP2CB;PPP2CA CASP3 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260910%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair H4C6 NBN RAD51 RNF168-1 RNF8 PRKDC RAD54L ATM MDC1 NASP-1 TP53BP1 SUPT16H XRCC6 XRCC5 H4-16 NAP1L1 SSRP1 SETD2 H4C1 AUTOPHAGY%WIKIPATHWAYS_20260910%WP4923%HOMO SAPIENS Autophagy UVRAG DEPTOR ATG16L1 PRKAA1 ATG101 PIK3R4 ATG9A RB1CC1 PRKAA2 PRKAG1 WIPI2 PRKAG2 BECN1 PRKAG3 AMBRA1 PRKAB2 RPTOR ATG14 PRKAB1 ATG13 MLST8 ULK1 MTOR ATG3 MAP1LC3B2;MAP1LC3B-1 ATG12-1 AKT1S1 PIK3C3 ATG7 ATG5 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260910%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO4A1 HSD17B1 SLCO1A2 CYP19A1 HSD17B2 HSD17B3 ESR2 HSD3B1;HSD3B2 SLCO2B1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLCO4C1 ESR1 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260910%WP545%HOMO SAPIENS Complement activation C1QB C3-1 C1S CFP C1QC C1R C2 C6 C7 C9 CD55 C8B C8A C8G LOC110384692;C4A;C4B_2;C4B MASP2 C5 MASP1 CFB CFD PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260910%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA TALDO1 RPE;RPEL1 G6PD PGLS DERA TP53 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260910%WP4658%HOMO SAPIENS Small cell lung cancer TRAF6 NFKBIB RXRA ITGAV IKBKB ITGA3 ITGA2 RB1 IKBKG CHUK CDKN1A CDKN1B CDKN1C ITGA6 RELA CASP9 SKP1 TRAF2 BCL2L1 NFKBIA CASP3 FN1 MAX CCND1 MYC NOS2 APAF1 TRAF4 BIRC7 BIRC2 BIRC3 ZBTB17 DDB2 CCNE2 COL4A2 PTEN COL4A1 CDKN2B CCNE1 POLK COL4A4 COL4A6 TP53 CKS1B FHIT CYCS-1 E2F1 E2F2 LAMB4 E2F3 BAK1 BID GADD45B GADD45A GADD45G CDK6 CDK4 CDK2 LAMC3 LAMC2 CASP8 LAMC1 PIK3R3 BAX TRAF5 TRAF1 PTGS2-2 LAMA5 LAMA2 TRAF3 LAMA1 LAMA4 LAMA3 RXRB BCL2 ITGA2B RXRG COL4A3 COL4A5 LAMB3 LAMB2 LAMB1 PIK3CD AKT2 CKS2 AKT3 PIK3CB AKT1 RARB PIK3R2 PIK3CA PIK3R1 PTK2 ITGB1 NFKB1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 IL3 SIGNALING%WIKIPATHWAYS_20260910%WP286%HOMO SAPIENS IL3 signaling JAK2 MAPK3 JAK1 BAD STAT3 PTPN11 CCR3 VAV1 GAB2 FOS HCK RAPGEF1 CBL GRB2 IL5RA INPP5D CSF2RB SOS1 LYN SYK STAT5A STAT5B BCL2L1 SHC1-1 PTPN6 CXCL8 SRC YWHAB YWHAQ IL3 ENPP3 MAPK8 HRAS IL3RA JUN CRKL BCL2 RAF1 PRKACA-1 FYN CD69 PIK3CD CD86 AKT1 PIK3R2 PIK3R1 TGFB1 MAP2K2;MAP2K1 MAPK1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260910%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling TRAF6 JUNB MAP2K4 HBEGF MAPK14 ATF2 MAPK12 ELK1 MAPK13 MAPK11 RB1 CDKN1A FOS IL6 MMP2 TRAF2 BCL2L1 CCND1 IL2 IFNG PDGFRA CFLAR TNF CCNE1 BMF TP53 NFE2L2 CCNA2-1 EGFR FGF7 BAK1 BID MCL1 MAPK8 FAS BAX HSP90AA1 TNFRSF1A MAP2K7 TRAF5 MAP2K6 MAP2K3 JUN BCL2 BCL3 BCL2L11 MAP3K5 FASLG CDKN2A TNFSF10 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260910%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer NRP1 CDH5 MAPK3 COL1A1 COL1A2 PLXNA1 PLXNA2 CCN2 CDKN1B HGF SNAI1 SNAI2 MMP2 RELA MMP9 EGF SRC CHD1 KDR CCNE2 BCAR1 CCNE1 SLC39A4 EGFR RELB VEGFA PECAM1 GSK3A CHD2 CDK2 SEMA3A SMAD4 TGFBR1-1 MET SMAD2;SMAD3 AKT2 AKT3 AKT1 TGFBR3 PLXNA4 REL TGFB2 PTK2 FLT1 TGFB3 MAP2K2;MAP2K1 NFKB1 MAPK1 NFKB2 RAC1 TGFBR2 PEPTIDE GPCRS%WIKIPATHWAYS_20260910%WP24%HOMO SAPIENS Peptide GPCRs MC5R OPRL1 CCR9 TACR3 GHSR NPY1R HCRTR2 HCRTR1 CCR3 CCR2 TSHR C3AR1 TACR1 OPRK1 NPY5R CCR8 CCR6 AVPR2 SSTR2 OPRM1 C5AR1 SSTR1 SSTR3 CX3CR1 SSTR4 SSTR5 CXCR6 MC3R OXTR CXCR5 GRPR EDNRA LHCGR EDNRB TRHR FSHR FPR1 MC2R GALR3 GALR2 GALR1 CCR10 NTSR1 NPY2R NTSR2 CCR1 NMBR GNRHR MC1R CXCR4 BDKRB2 NPY4R2;NPY4R BRS3 MC4R CCKAR CCR7 CCR5 CCR4 AVPR1B FPR2 ACKR1 BDKRB1 AVPR1A ATP8A1 CCKBR TACR2 TAC4 AGTR1 AGTR2 OPRD1 CXCR1 CXCR3 CXCR2 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260910%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 ADRB2 MYC ESR2 PAX7 FBXO32 UPF1 PPARGC1A RET EP300 CDKN1A TRIM63 DUX4;DUXA MYF5 VEGFA MYOD1 MYOG CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260910%WP5603%HOMO SAPIENS Caffeine in myocytes MYL3 MYH6 RYR3 RYR2 TNNI3 ACTC1;ACTG2 TPM4 TPM2 ACTG1 TPM3 RYR1 ACTA1 MYH11 TNNI1 TNNI2 TNNC2 MYH3 TNNT1 TNNT3 MYH8 MYLPF MYL6 ACTB-1 MYH13 TPM1 ACTA2 MYH1 TNNC1 MYH7 TNNT2 MYL2 MYL1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260910%WP3963%HOMO SAPIENS Mevalonate pathway MVD HMGCS1-1 HMGCR PMVK FDPS MVK ACAT2 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260910%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways NR1H3 IDI1 EBP CYP51A1 MVK NSDHL SC5D MSMO1 DHCR24 HSD17B7 DHCR7 ACAT2 LBR TM7SF2 HMGCS1-1 PMVK SREBF1 ACOT2;ACOT1 FDFT1 MYLIP FDPS GGPS1 NR1H2 ELOVL3 ACSL3 LSS FASN CH25H ABCG1 ABCA1 HMGCS2 SQLE SOAT1 CYP46A1 SREBF2 FADS2 ACSL1 SCD FADS1 SOAT2 ELOVL4 MVD HMGCR ELOVL2 ELOVL5 CYP27A1 ACSL4 TP53 NETWORK%WIKIPATHWAYS_20260910%WP1742%HOMO SAPIENS TP53 network MYC BOK BAX ATM TP53 MDM2-2 CDKN1A TP73 ABL1 TP63 OTX2 CDKN2A BBC3 PMAIP1 BID TNFSF10 GADD45A BCL2 SUMO1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260910%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TRAF6 PLEKHM1 TNFRSF11A TNFSF11 CLCN7 OSTM1 SNX10 TCIRG1 NFKB1 RAB7A IKBKB RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260910%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 NPR1 IL1B KNG1 PRKG1 SERPINE1 REN VDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AGT RHOA F12 BDKRB2 SERPING1 KLKB1 CPN1 CYP24A1 ROCK1 NOS1 IL1A KLK1 NOS3 TNF BDKRB1 ACE2 ACE AGTR1 AGTR2 NFKB1 MAPK1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260910%WP4742%HOMO SAPIENS Ketogenesis and ketolysis SLC2A1 UCP2 BDH1 OXCT1-1 SLC16A1 ACAT1 CPT2 SLC25A20 HINT1 PATHWAY%WIKIPATHWAYS_20260910%WP5523%HOMO SAPIENS HINT1 pathway TCF4 ERCC3 MAPK9 GTF2H2C;GTF2H2C_2;GTF2H2 ERCC2 RUVBL1 CDK7 MNAT1 CCNH NFATC2 SH3RF1 CTNNB1 FOS JUN KARS1 GTF2H1 GTF2H3 USF2 MITF NFKB1 HINT1 GTF2H4 RUVBL2 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway BCLAF1 MAPK3 NRAS MAP3K2 MAPK14 ATF2 HRAS MAPK11 VAV1 RPS6KA1 GAB2 SPAG1 CBL KRAS GRB2 INPP5D SOS1 CRK SHC4 CRKL SHC1-1 SHC2 BCL2 DOK1 SRC RAF1 ARAF EIF4B BCAR1 AKT2 AKT3 SHC3 AKT1 PXN HSPB1 ABL1 BCR BRAF PIK3R1 PTK2 PIK3CA MEF2C MAPK1 HSPB2 BCL9 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260910%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PMEL TYRP1 ASIP MLANA PLCB3 PLCB4 GNAS-1 ARRB1 POMC GNAQ ARRB2 PLCB1 MC1R PLCB2 ADCY4 ADCY2 MITF PRKACB-1 GNA15 TYR PRKACA-1 DCT CREB1 GPR143 ADCY9 SERPINF1 VEGFA ITPR1 PRKCB IRINOTECAN PATHWAY%WIKIPATHWAYS_20260910%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 CES2 BCHE ABCG2 CES1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 UGT1A1;UGT1A6 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260910%WP4830%HOMO SAPIENS GDNF RET signaling axis EYA1 BMP4 GDNF WT1 ROBO1 LHX1 HOXC11 FOXC2 FOXC1 FAT4 RET GFRA1 SOX11 CTNNB1 GREM1 HSPB11 SALL1 SIX2 IFT27 GATA3 HNF1B ROBO2 GLI3 HOXD11 SOX17 HOXA11 PAX2 AGTR2 SLIT2 ALDH1A2 SPRY1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260910%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease H2AZ2;H2AZ1 DES NOTCH3 DMPK LMNA HP1BP3 HSPB3 LBR LMNB1 ACTA1 MEF2C MYOD1 MYOG CBX5 HSPB2 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260910%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment NRP1 CXCL10 CSF2 FAS ITGB6 CCR2 CXCR4 CXCL12 IFITM3;IFITM2;IFITM1 CCR5 KDR CCL5 CSF2RA BAG3 CD86 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CSF1R CCL13;CCL2 CSF1 CD80 FASLG HLA-DRA CTLA4 CXCR3 VEGFA TGFB1 LAG3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260910%WP554%HOMO SAPIENS ACE inhibitor pathway CTSG NR3C2 ATP6AP2 KNG1 CMA1 NOS3 REN BDKRB1 AGT ACE2 ACE AGTR1 AGTR2 MAS1 BDKRB2 TGFB1 CYP11B1;CYP11B2 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5407%HOMO SAPIENS 15q11q13 copy number variation TJP3 TJP2 CREBBP SPEF1 SMC5 SMC6 NSMCE3 NSMCE2 CDC42BPB NSMCE1 EID3 GJD3 NECAB3 LYPD6 GJC2 GJA1 UBN1 GCOM1;MYZAP TRPM3 RELA RIC3 APP SLF1 CANX SLF2 FAM189A1 CGN DNMBP MITF APBA2 FANCD2 ANKRD2 CALM1 FANCI STXBP1 TJP1 CXADR MTMR10 KLF13 OTUD7A CHRNA7;CHRFAM7A TRPM1 KAT2B CCL5 SERPINH1 FAN1 STX1A SIN3A HDAC1 OCLN-1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260910%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders POT1 TPP1 H4C6 TERF1-1 TERF2 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TERF2IP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC5 H2BC1 H2BC15;H2BC3;H2BC11;H2BC12 H2AC20 H2AB2;H2AB3;H2AB1 H4-16 H2BC21 ACD TINF2 H2AC14 H4C1 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5400%HOMO SAPIENS 6q16 copy number variation INSR MC4R SIM1 NPY GHSR GHRL LEP POMC AGRP NTRK2 BDNF LEPR INS;INS-IGF2 ARNT MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260910%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies MS4A1 S1PR1 S1PR4 S1PR3 S1PR5 ITGB1 BTK ITGA4 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260910%WP247%HOMO SAPIENS Small ligand GPCRs PTGFR PTGER3 LPAR1 S1PR4 TBXA2R PTGDR PTGIR CNR2 PTGER4 PTGER2 S1PR1 S1PR3 S1PR2 PTAFR CNR1 MTNR1A MTNR1B PTGER1 GPR50 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260910%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases HEXB NEU2 GM2A PSAP NEU1 HEXA GLB1 LIPA NPC2 ARSA GBA GALC NEU3 SCARB2 NEU4 NPC1-1 GLA NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260910%WP288%HOMO SAPIENS Nod like receptor NLR signaling CHUK IKBKG MAP3K7 RELA MAPK8 ERBIN EPHB2 CD40 IKBKB EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260910%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways WNT11 MAPK7 MAPK6 MAPK4 WNT7B MAPK12 ELK1 FGF21 CTNNB1 FOS EGF PDGFB PDGFRB FGF2 MDM2-2 HNF1A LIF BMP4 MAP2K6 MAP2K3 JUN RAF1 FZD1 FZD3 WNT3A WNT5A WNT7A ACVR1 WNT3 LRP6 AKT2 AKT3 AKT1 MTOR GSK3B PIK3R2 MAP2K2;MAP2K1 MAPK1 JAK1 STAT3 GAB1 PTPN11 GRB2 ACVR2B IL6ST SOS1 DVL1 PDGFA DVL2 FGF20 DVL3 FGF23 FGF22 FGF17 FGF16 ACTR2 PDGFRA FGF19 SMAD7 PTEN FGF1 AXIN1 FGF3 FGF4 FGF5 FGF6 EGFR FGF7 FGF8 FGF9 FGF14 WNT5B APC FGF13 FGF12 FGF11 HRAS WNT6 WNT1 WNT2 WNT4 WNT10B SMAD1 WNT10A SMAD4 FZD2 FZD5 FZD4 FZD7 FZD6 FZD9 SMAD9 FZD8 ARAF SMAD5 FGF18 FGFR4 BMPR1B FGFR3 FGFR2 BMPR1A FGF10 FGFR1 WNT2B SELENOP BMPR2 PIK3CD NOG LIFR MAP2K5 SMAD6 WNT9B BRAF WNT16 ERAS LRP5 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260910%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport ST20-MTHFS;MTHFS ALDH1L1 MTHFR QDPR SHMT1 SLC46A1 ALDH1L2 MTHFD2L TYMS MTR-1 FTCD ATIC SLC19A1 DHFR2;DHFR FOLR1 MTHFD1 MTHFD2 GART SHMT2 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260910%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis ISCU NARF ABCB7 NUBP1 NUBP2 NFS1 LYRM4 FDX1 FDXR FXN CIAO2B GLRX5 HSPA9 HSCB NFU1 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260910%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TRAF6 IRAK1 RELA TLR2 SPI1 TLR4 APOE NFKB2 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260910%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta PLOD1 ADAMTS2 COL1A1 SP7 COL1A2 WNT1 P4HB LOX BMP1 P4HA1 TNFSF11 P4HA2 CREB3L1 TNFRSF11B FZD1 TNFRSF11A SERPINH1 LRP6 MBTPS1 FKBP10 MIA3 PLOD2 TMEM38B COLGALT1 SERPINF1 IFITM5 CRTAP P3H2 P3H1 MBTPS2 ITPR1 PPIB LRP5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260910%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 STAG1 PTTG1;PTTG2 SMC3 CENPE CDC20 ESPL1 BUB1B BUB3 MAD2L1 BUB1 MAD1L1 APC TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias MAPK9 MAPK3 JAK1 SERPINE1 CREBBP STAT1 ITGB6 STAT3 EP300 CTNNB1 FOS FBN1 EGF SPP1 IFNG SKIL SMAD7 TNF LEF1 LIF ADAMTSL2 LTBP3 ADAMTS10 BMP4 RUNX2 HRAS WNT1 SMAD1 SMAD4 JUN TGFBR1-1 TFE3 SMAD2;SMAD3 SMAD9 SMAD5 RUNX3 ZFYVE9 TGIF1-1 FST LEFTY2;LEFTY1 NOG FOXH1 TGFBR3 ZEB2 ENG LTBP1 THBS1 ZNF423 INHBA SMAD6 FKBP1A SKI BAMBI TGFB1 NFKB1 TGFBR2 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260910%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming POU5F1;POU5F1B MYC KLF4 SOX2 EGR1 TRIM71 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260910%WP5050%HOMO SAPIENS TCA cycle in senescence GOT1-1 PDHA1 MDH1 BRAF PDK1 PDP2 FH ME1 ME2 TP53 SLC25A46 PATHWAY%WIKIPATHWAYS_20260910%WP5521%HOMO SAPIENS SLC25A46 pathway APOOL MMGT1 IMMT MICOS10 APOO CHCHD3 CHCHD6 EMC1 SLC25A46 EMC2 EMC3 EMC4 EMC6 EMC7 EMC8 EMC10 DNM1L MFN1 MFN2 MICOS13 OPA1 IL1 SIGNALING%WIKIPATHWAYS_20260910%WP195%HOMO SAPIENS IL1 signaling TRAF6 MAP3K7 MAPK9 MAPK3 NFKBIB MAP2K4 MAP3K2 MAPK14 ATF2 IKBKB PTPN11 IKBKG CHUK RELA NFKBIA IL1A IL1RAP IRAK1 IRAK2 MAP3K3 TOLLIP SQSTM1 TAB3 TAB2 TAB1 MAP3K14 MYD88 IL1B MAPKAPK2 MAPK8 PLCG1 PRKCZ IRAK3 PELI1 MAP2K7 PELI2 UBE2N MAP2K6 MAP2K3 JUN MAP3K1 UBE2V1 IL1R1 ECSIT AKT1 REL PIK3R2 PIK3R1 IRAK4 MAP2K2;MAP2K1 NFKB1 MAPK1 HSPB2 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260910%WP4217%HOMO SAPIENS Ebola virus infection in host ITGB3 IRF3 VPS11 VPS16 ITGAV ITGA4 EP300 ITGA3 FOLR1 TFAP2A ITGA2 ITGA1 VAV2 ACTG1 ITGA6 RELA ITGA5 FLNA VPS33A ACTN1 ACTN4 CDC42 PAK1 RFC1 CLTC CLTA HLA-DPB1-1 ACTB-1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DOA VPS41 HLA-DOB HLA-DRA HLA-DPA1 EIF2AK2 HLA-DQB2;HLA-DQB1 RELB HLA-DMB HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CLEC4M;CD209-2 RAB9A FLNB FLNC HAVCR2 CLTCL1 MBL2-1 BST2 NPC2 AKT1 MFGE8 ADAM17 REL PIK3R2 PIK3R1 NPC1-1 SOCS3 NFKB1 NFKB2 MAPK1 RAC1 TOP1 MAPK3 RHOB CREBBP STAT1 EIF2S1 RAB5A TPCN2 NEDD4 IGF1R RHOC TYRO3 RASA2 C1QBP GAS6 IL4 EPS15 MERTK PRKRA TLR4 RAB7A IQGAP1 EGFR IRF7 CTSB PIK3R3 ICAM2 GSN ICAM3 KPNA1 TIMD4 RHOA CLEC4G SCIN VPS39 CLEC6A CLTB ASGR1 DAB2IP HLA-DMA CTSV;CTSL AXL TIAM1 PIK3CD TSG101 PIK3CB CAV3 CAV2 CAV1 TBK1 PIK3CA VPS4A ITGB1 IKBKE VPS18 DDX58 ADIPOGENESIS%WIKIPATHWAYS_20260910%WP236%HOMO SAPIENS Adipogenesis UCP1 RXRA FOXC2 PPARGC1A PPARD CTNNB1 RB1 CDKN1A CEBPA CNTFR STAT5A STAT5B KLF6 LIPE CFD E2F4-1 NRIP1 ID3 CELF1 CREB1 TNF NCOA2 GDF10 HNF1A NCOR1 PPARA RBL1 E2F1 LIF GADD45B GADD45A IGF1 BMP4 BMP2 NR1H3 LMNA ZMPSTE24 FAS WWTR1 FRZB SREBF1 IRS1 IRS2 ADIPOQ NR3C1 FOXO1-1 LPIN1 INS;INS-IGF2 LPIN2 NR2F1 DDIT3 RXRG FZD1 EBF1 MEF2D STAT2 SCD CISD1 IRS4 RBL2 SOCS1 RARA NAMPT STAT6 PRLR TGFB1 SOCS3 EPAS1 TRIB3 MEF2A MEF2B;BORCS8-MEF2B ASIP NCOA1 SERPINE1 NCOR2 STAT1 MIF STAT3 LEP GATA4 AGT CYP26A1 IL6 IL6ST SFRP4 NDN CEBPB OSM CYP26B1 DVL1 AGPAT2 BSCL2 LPIN3 SP1 EGR2 CEBPD GATA3 GATA2 KLF15 KLF5 AHR MEF2C WNT5B HIF1A PTGIS MIXL1 WNT1 BMP3 WNT10B BMP1 MBNL1 GTF3A PLIN2 SPOCK1 RORA KLF7 PCK1 SMAD2;SMAD3 SLC2A4 PCK2 PNPLA3 LIFR RETN PPARG LPL PLIN1 DLK1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260910%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 FOXQ1 GPRC5D DKK1 CCN2 GTPBP4 CTNNB1 GJB6 FOS ZBTB16 TP63 MSX1 KITLG IFNG DSC2 DKK4 EGR2 GLI2 GATA3 RBPJ SOX9 GAS1 LEF1 EGFR SFRP1 CD34 S100A4 IGF1 BMP4 TCF4 NOTCH2 KLK6 NOTCH1 WIF1 IGFBP5 KRTAP8-1 BMP6 DKK3 SOX2 SMAD1 SMAD4 NR3C1 ELANE JUN MSX2 FOXE1 HR CD200 HOXC12 PHLDA1 SPINK6 LHX2 SPINK5 KRTAP3-2;KRTAP3-3-1 ADAMTS20 DSG1 FZD1 DSG4 DLX3 PROM1 NFATC1 CASP14 RUNX3 KLK5 WNT5A KLK4 KLK7 BMPR1A CUX1 LRIG1 FST GSDMA KLK13 SOSTDC1 KLK14 BCL11B FOXN1 KRT19 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 LGR5 ADAM17 FOSB NFKB1 PERP KRT15 KETOGENIC DIET IN EPILEPTOGENESIS%WIKIPATHWAYS_20260910%WP5639%HOMO SAPIENS Ketogenic diet in epileptogenesis SLC2A1 HDAC3 HDAC2 LDHA GAD1 ERBB4 HMGCS1-1 GLUD1;GLUD2 HCAR2;HCAR3 TXNIP SLC25A14 SLC25A27 UCP2 AKT3 SIRT4 NFE2L2 HDAC8 KCNA1 ABCC8 PPID HDAC1 NLRP3 RPS6 CAT NRG1 PPARG KCNJ11 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260910%WP2113%HOMO SAPIENS Type III interferon signaling IRF9 JAK1 STAT2 STAT1 IFNLR1 IFNL2;IFNL3;IFNL1 IL10RB TYK2 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260910%WP2007%HOMO SAPIENS Iron metabolism in placenta TFRC ACO1 TF TFR2 SLC11A2 HEPHL1 SLC40A1 MCOLN1 STEAP3 HAMP IREB2 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260910%WP3947%HOMO SAPIENS Serotonin and anxiety GABRA1 HTR2A CAMK2B PPP3CA FMR1 GRM1 HTR1A PLCD4 POMC FOS ARC ADRA1A EEF2K PLEK PRKCB TRPV1 CRH NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260910%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum H4C6 CUL4A GPS1 ERCC3 ERCC4 POLE2 RPA3 ERCC1 POLE3 ERCC2 ERCC8 ERCC6 CUL4B UVSSA BRCA1 RFC1 DDB2 XAB2 POLK CCNH LIG1 LIG3 RBX1 RPA2 XPA XPC H3-3A USP7 XRCC1 PARP1 SLX4 CDK7 MNAT1 CETN2 POLE POLH RFC5 RFC3 RFC4 RFC2 RAD23A RAD23B DDB1 GTF2H2C;GTF2H2C_2;GTF2H2 POLD3 POLD4 POLD1 POLD2 PCNA SLX4IP H4-16 HMGN1 RPA1 GTF2H1 CHD1L GTF2H3 RAD18 GTF2H4 H4C1 POLE4 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G5 PLA2G6 FADS2 ACSL1 JMJD7-PLA2G4B;PLA2G4B FADS1 ACOX1 PLA2G4A ACOX3 ELOVL2 ELOVL5 ACOT2;ACOT1 ACSL3 ACSL4 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260910%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TFAP2A RHOA ARHGEF2 TP63 IRF6 ARHGAP29 TGFB3 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260910%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CYP27B1 MAPK9 MAPK3 JAK1 MAPK7 RXRA PLCG2 STAT1 PRKCD MAPK14 MAPK12 MAPK13 IKBKB ISG15 TYK2 MAPK11 DEFB4A;DEFB4B PLCD1 IL6 CXCL8 IFNG CD40LG SP1 TLR8 TLR4 TNF RELB PRKCG PRKCH PRKCB PRKCE PRKCA PRKCQ CAMK2B CAMK2D NRAS MAPK8 CAMK2A HRAS PRKCZ PLCB3 VDR PLCB4 SP3 MED1 CAMK2G TNFRSF1A PLCB1 PLCB2 KRAS JUN ETS1 NOD2 CYP24A1 CD40 RXRB RXRG IFNGR1 IFNAR2 STAT2 IFNGR2 TLR2 CAMP CCL13;CCL2 IFI44L CAV1 IFI27L2 PLCE1 RSAD2 NFKB1 MAPK1 NFKB2 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260910%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL HMGCS2 BDH1 OXCT1-1 ACAT1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260910%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHC SDHD SDHA SDHAF2 SDHAF3 SDHB SDHAF1 SDHAF4 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260910%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging SIRT1 MTOR IGF1R FOXO1-1 PTEN AKT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260910%WP1531%HOMO SAPIENS Vitamin D metabolism CYP2R1 CYP27B1 CYP27A1 RXRA PTH CYP24A1 RXRB VDR DHCR7 GC CYTOSINE METHYLATION%WIKIPATHWAYS_20260910%WP3585%HOMO SAPIENS Cytosine methylation IDH2 DNMT1 IDH1 MECP2 TET2 TET1 MBD3 TDG CAFFEINE IN NEURONS%WIKIPATHWAYS_20260910%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADORA2A ADRA1D ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260910%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias NKX3-2 MGP ADAMTS1 CHST11 ALPL PLAT STAT1 PLAU DDR2 CDKN1C IGF1R CAB39 ACAN MMP9 STAT5B SPP1 KIF3A BMP7 FGF2 IHH HDAC4 IFT88 SOX9 SOX6 SOX5 VEGFA MEF2C IGF1 CALM1 RUNX2 COL10A1 IGF2 GHR FRZB PTH1R HMGCS1-1 BMP6 SCIN THRA CTSV;CTSL PTCH1 SLC38A2 FGF18 ADAMTS5 PRKACA-1 MMP13 RUNX3 FGFR3 BMPR1A SERPINH1 FGFR1 TIMP3 COL2A1 AKT1 GLI3 ENPP1 PTH TGFB2 TGFB1 ADAMTS4 PTHLH PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP4147%HOMO SAPIENS PTF1A related regulatory pathway CTNNB1 RBPJ NKX6-1 PTF1A RBPJL KAT2B NOTCH1 HES1 PROX1 FGF10 PDX1 IL17 SIGNALING%WIKIPATHWAYS_20260910%WP2112%HOMO SAPIENS IL17 signaling JAK2 TRAF6 MAP3K7 IL17RE MAPK3 NFKBIB JAK1 IL17RC STAT3 IKBKB IKBKG TRAF3IP2 RELA TRAF3 CEBPB IL25 SP1 IL17RB CEBPD AKT1 IL17RA GSK3B IL17RD IL17D PIK3CA IL17C IL17F IL17B NFKB1 MAPK1 IL17A MAP3K14 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260910%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes NRP1 BCKDHB RHEB CACNA2D1 CCND1 VCAM1 GNAI2 FGF2 AP2A1 UBE2J1 MAP3K8 SLC38A1 HARS1 CPNE8 VEZT ACAA2 SRPRB-1 ZEB1 ARF4-1 PWP1 DHX57 ARFIP1 CIAO2A POGLUT3 RARS1 TPM3 FNDC3B G6PD FNDC3A GOLGA7-1 DHX40 IDH1 RAB34 RAI14 ABCF2-H2BE1;ABCF2 SRSF9 TMED10 CBFB MRPL20 COMMD9 SLC38A2 ANPEP ATP6V1C1 ATP6V1F PEDS1-UBE2V1;PEDS1 SLC4A10 TBCA MOV10 NCL-1 HNRNPM WNT5A CHMP2A ANP32B PICALM TRAM1 ADAR MAGT1 MRC2 SPTLC1 SH3BGRL3 TMED7 TMED2-1 ELOVL5 ATRX SIGMAR1 CAPG PRPF40A CSDE1 TCL1A POM121;POM121C PXDN PTMA PNP-1 MTPN SEC23A MRPS33 AKAP8 DNAJB1 POLR2C PPP1R7 SH3BP4 PDLIM7 MPZL1 SLC12A2 GALNT7 TXNRD1 GALNT1 AP3D1 ARCN1 TMEM59 SPCS3 FMNL2 ATP6V0E2;ATP6V0E1 GYS1 NEDD4 PDCD4 LAMTOR5 PLXND1 BET1 FXR2 COL4A2 NCOA3 EGFR E2F3 PRKCI SLC12A4 ARL10 NOTCH2 NOTCH1 TYMS LAMC2 LAMC1 DNMT3B TRIP13 MTHFD2 SMAD1 CXCL12 PANX1 RAB5C BCL6 CPOX PPP2R5C CDKN2A MAT2A MAPK7 MAPK14 MAPK12 CTNNB1 RB1 PKN2 CDKN1A CSNK1D CDKN1B CLOCK SMC1A SLC25A22 SLC25A13 SUCLG2 ARHGDIA TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A E2F1 IQGAP3 CDK6 IRS1 MYLIP FBXW11 DDX5 RAD23B TDG GFPT1 POLD2 USP1 TGFBR2 POLE4 IFRD1 CCN1 GPD2 CAP1 PHC2 HIPK3 CUL4B IGF2R CSRP1 ELMOD2 CDKN1C CEBPB SERPINE2 C1orf56 DCAF7 TERT PRIM1 KCNN4 SAC3D1 HMOX1 ADPGK ATAT1 PTRH1 SYPL1 UNC93B1 HDAC4 POLA2 MYB NELFCD MYCN KRAS NF2 CLDN1 GPAM MET AXL STRN FADS2 FADS1 NT5C3A MYO1E PPP5C NFIA IPO4 CHAF1A LMNB2 LPL RRP8 HOXA5 GTPBP3 OTULINL PKM CEP72 VTI1B FERMT2 HOXD8 VAMP3 TAF9B TRMT1 LY6K MSI2 NPR3-1 ARFIP2 BRI3BP RCOR1 MEOX2 PURA MTX1 YIF1B GEMIN2 ARID2 UTP15 MARS2 RBM19 PTBP1 DHX15 PPP3R1 PTBP2 KIT NT5E PPP3CA TUBA1A BACE1 SRSF10 CDIPT EIF4E TNFSF9 BCL2 CYP1B1 SEC24A PPIF RTN4 RHOB GSTM4 ATP2A2 AGO3;AGO1 SYNE2 SYNE1 TMEM43 GNA13 TPM1 CDKAL1 CYP51A1 BACH1 RAB23 CHORDC1 RAVER2 CDK5RAP1 ANKFY1 SEC62 TRPV6 VPS39 CDK5RAP3 TMEM41B-1 MBNL1 SCAMP1 CARHSP1 METTL7A-1 PDE3A WDR82 KCNQ1 FAR1 HACD3 GRPEL2 ATP6V0A1 SNX6 RAB27B NCEH1 SFXN1 PTPA GFM1 ASH2L PTPRJ PTPRF COIL PISD TMED3 GNL3L-1 GNPNAT1 CTSC MRPS24 RHOG AP3B1 GAK SLC7A6 CDCP1 FRG1 BRPF3-1 SSNA1 AMIGO2 NAPG PGRMC1 SHOC2 SPRYD4 TTC9C WDR11 TPPP3 SNX15 LRRC8A NUCB1 LAMTOR3 TUSC2 LTN1 ARID4B SDCBP LCLAT1 ABHD10 KPNA3 TPM4 TPM2 ATG9A GAS2L1 STX7 ITGA2 UBE4A RAB30 DMTF1 WDFY1 MATR3 GEMIN7 SLC1A4 UAP1 CORO1C SLC9A3R2 RAB6A ANAPC1 CD164 CNOT9 SLC25A1 DOCK5 CALCOCO2 SNAP23 DOCK7 TNFAIP2 CHD1 TMEM109 PLK1 ACP2 SNAP29 SCYL1 HSDL1 ARID1A RCN2 RFT1 RBMS1 LUZP1 YWHAQ NUFIP2 NXN UHRF1 CAND1 TP53INP1 IGF2BP1 ZNF622 PDLIM5 SLC25A24 MYO10 EHMT2 TM6SF1 SLC4A7 EHMT1 SLC25A32 NAA15 DNMT3A EZH2 UBE2S ANXA2 PLAG1 BDNF ADIPOR2 RDH10 NARS1 PPIB ABCG2 MTRR TXN2 C1QBP ATG3 ATAD3A;ATAD3B MCL1 HSD17B12 PGM1 P4HA2 PSAT1 THEM4 AURKB PAFAH1B2 ABHD11 MPDU1 CORI CYCLE%WIKIPATHWAYS_20260910%WP1946%HOMO SAPIENS Cori cycle SLC2A1 SLC2A4 GPT ALDOA LDHA GAPDH-1 PGAM1 PGK1 SLC2A2 HK1 TALDO1 G6PD PFKP INS;INS-IGF2 TPI1 GPI 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260910%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways CYP7A1 EBP EPHX2 DHCR7 ACOX2 ACOT2;ACOT1 SLC27A5 HSD11B1 HSD11B2 SCP2 NPC2 THEM5 ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 CYP27A1 DBP AMACR BAAT ACOT6 NPC1-1 SLC27A2 ACOT4 RAS SIGNALING%WIKIPATHWAYS_20260910%WP4223%HOMO SAPIENS Ras signaling RASGRF2 MAPK9 PLA2G5 PLA2G6 JMJD7-PLA2G4B;PLA2G4B RAC3 HTR7 ETS2 ELK1 IKBKB MAPK10 CHUK GAB2 RELA CALML6 CALML3 CALML4 FOXO4 RIN1 PRKACB-1 RASAL1 RASAL2 CDC42 RASAL3 PAK1 TTBK1 BRAP RGL1 PAK3 RGL2 PAK2 RASA4;RASA4B PAK4 KDR PLAAT3 RASSF5 KSR2 RALGDS PLA2G2F RASGRP2 LAT PLA2G2E PDGFRB PLA2G2C RASGRP4 PLD2 RASGRP3 GNB5 GRIN2A ABL1 RALB KIT GRIN2B CALM1 CALM2 RASGRF1 RASA1 PLA2G2A-1 MAPK8 PLA2G4A RAF1 CALM3;CALM1 GRIN1 FLT3 AKT2 AKT3 AKT1 REL PLCE1 PIK3R2 PIK3R1 ZAP70 STK4 NFKB1 MAP2K2;MAP2K1 EPHA2 MAPK1 AFDN RAC1 GNG10 ARF6 MAPK3 NGFR GNG13 PLCG2 NTRK1 BAD ABL2 GAB1 PTPN11 RAB5A GNGT1 IKBKG IGF1R RRAS GRB2 PLD1 SOS1 BCL2L1 RASA2 SHC4 SHC1-1 SHC2 INSR PDGFRA FLT4 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G4E PLA2G3 CSF1R SOS2 PLA2G10;LOC100652777 EGFR RAPGEF5 PRKCG PRKCB GNB2 PRKCA GNB1 GNB4 GNB3 RASGRP1 NRAS PLCG1 PLA2G1B PIK3R3 PLA1A HRAS SYNGAP1 NF1 RALBP1-1 RHOA RALA-1 RASA3 EXOC2 KRAS ETS1 BUB1B-PAK6;PAK6 MET GNG2 GNG5 PAK5 FGFR4 GNG4 PRKACA-1 GNG8 FGFR3 TIAM1 FGFR2 RAB5B RAB5C FGFR1 PIK3CD RRAS2 MRAS SHC3 PIK3CB RAP1B RAP1A FASLG TEK KSR1 NTRK2 PIK3CA FLT1 RASSF1 SHOC2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260910%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis DLL1 EPHA4 MESP2 WNT3A FGF8 NOTCH1 HES1 LFNG TBX6 HES7 RIPPLY2 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260910%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL2 IL4 IFNG FAS IL12A IL5 CD86 CD80 CTLA4 VIP TGFB1 CD28 IL10 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP23%HOMO SAPIENS B cell receptor signaling MAP3K7 MAPK9 TEC CD79B CD19 CD79A PLCG2 CD81 PIP5K1A MAPK4 PIP5K1B PRKCD PIP5K1C MAPK14 ATF2 ELK1 GAB1 IKBKB PDPK1 PTPN11 IKBKG CHUK VAV1 GAB2 VAV2 CR2 RAPGEF1 CBL PTPRC RELA GRB2 INPP5D SOS1 CRK LYN SYK BTK NFKBIA SHC1-1 CARD11 BCL10 PTPN6 MALT1 MAX CDC42 MYC CREB1 BLK KLF11 DAPP1 RASGRP3 SH3BP2 PTPN18 GSK3A NFATC3 PRKCB MAPK8 CAMK2A PLCG1 HRAS NFATC2 MAP4K1 RPS6KA1 MAP2K6 FOXO1-1 JUN ETS1 NCK1 CRKL BLNK PIK3AP1 RAF1 CD22 LCK GTF2I FYN AKT1 HCLS1 PIK3CG BCL6 REL GSK3B PIK3R2 BRAF PIK3R1 LAT2 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome ITGB3 ILK SEPTIN2 NFKBIA MYO5A CALCRL CAPN10 ASCL1 TNF TP53 DGKD HDLBP HJURP ERFE KLHL30 PASK THAP4 AGAP1 COPS9-1 ESPNL TRPM8 OR6B2 UBE2F MTERF4 CXCL11 CALM1 STK25 SNED1 RTP5 GMEB1 RNPEPL1 ING5 IL1B LRRFIP1 KIF1A ILKAP PER2 AQP12B DUSP28 OTOS ARL4C SCLY ATG4B USP40 ARF5 DTYMK ASB18 CENPA CYTH2 CYTH4 SPP2 PRLH CYTH1 FARP2 SEPTIN6 MAB21L4 JUN MLPH RAB17 RBM44 ASB1 DISC1 NDUFA10 IL13RA1 GBX2 MAP1LC3A PRL RPS6 ARF1 MYOG RAC1 MEF2A PPP1R7 SH3BP4 PDCD1 CYTH3 AGXT GYS1 D2HGDH RRAGC RAMP1 RRAGA CALCA RRAGB RRAGD ABCA1 PDGFA BOK SEPTIN4-1 GPC1 CFLAR TRAF3IP1 HDAC4 UGT1A1;UGT1A6 NEU4 EGFR MAP1LC3B2;MAP1LC3B-1 HES1 GABARAPL2 HES6 MEF2C SEPTIN12 GABARAP EEF1A1 MAP1LC3C CXCR4 CXCL12 HAMP ACKR3-2 TRAF3 COL6A3 GPR35 RAB27A COPS8 IQCA1 TWIST2 IRF8 MYOD1 ITPK1 PDX1 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260910%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease SMAD2;SMAD3 RUNX2 MAPK3 SERPINE1 MAPK8 MAPK14 NR2C2 CCN2 TGFBR3 ANGPT2 ENG LTBP1 AGTR1 POSTN SMAD4 FBN1 FLNA TGFBR1-1 SHC1-1 FBN2 FBN3 MAPK1 LTBP2 TGFBR2 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260910%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2;SMAD3 POSTN YWHAG SMAD4 SERPINE1 TGFBR1-1 WWTR1 SPARC CCN2 TGFBR3 TGFBR2 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260910%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects MYB KLF2 PRL RGS16 CXCL12 ERBB4 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway MIF AIFM1 PARP1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260910%WP474%HOMO SAPIENS Endochondral ossification NKX3-2 MGP ADAMTS1 CHST11 ALPL PLAT STAT1 PLAU DDR2 CDKN1C IGF1R CAB39 ACAN MMP9 STAT5B SPP1 KIF3A BMP7 FGF2 IHH HDAC4 IFT88 SOX9 SOX6 SOX5 VEGFA MEF2C IGF1 CALM1 RUNX2 COL10A1 IGF2 GHR FRZB PTH1R HMGCS1-1 BMP6 SCIN THRA CTSV;CTSL PTCH1 SLC38A2 FGF18 ADAMTS5 PRKACA-1 MMP13 RUNX3 FGFR3 BMPR1A SERPINH1 FGFR1 TIMP3 COL2A1 AKT1 GLI3 ENPP1 PTH TGFB2 TGFB1 ADAMTS4 PTHLH OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260910%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP2J2-1 CYP4F22 CYP19A1 CYP27B1 CYP2C18-1 CYP4X1 CYP7A1 CYP2B6 CYP17A1 CYP2A13;CYP2A6;CYP2A7-1 CYP11A1 CYP2F1 CYP51A1 CYP4B1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP26A1 CYP27C1 CYP2S1 CYP8B1 CYP1A1 CYP2W1 CYP24A1 CYP11B1;CYP11B2 CYP26B1 CYP20A1 CYB5R2 CYP4V2 CYB5R1 CYP2R1 CYB5A CYB5R4 CYP46A1 POR CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP1B1 CYP39A1 CYP7B1 CYP27A1 CYP2U1 CYP2E1 CYB5R3 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260910%WP5408%HOMO SAPIENS 15q25 copy number variation SH3GL3 RNMT SLC2A1 DNM3 TOP1 BNC1 RYR2 GRM5 AP3D1 GRM1 SPCS3 SPCS1 NMBR RYR1 SHANK1 PDE8A EGF RAF1 RAMAC ZNF592 ADAMTSL3;ADAMTSL1 TENT4B AP3M2 BTBD1 C15orf40 FSD2 SHANK3 WHAMM SEC11A NMB AP3B2 HTT AP3S2;AP3S1 SPCS2 WDR73 ALPK3 HOMER2 SLC28A1 ZSCAN2 ITPR1 TM6SF1 CPEB1 AGAP2 SYNJ1 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260910%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HEY1 VEGFC HES1 VEGFA HIF1A VEGFB HIF1AN DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260910%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development DLL1 PSEN1 REST LATS2 CDKN1B SMARCB1 APP GLI1 CASP9 TFDP1 TFDP2 CASP3 E2F4-1 CCND1 DCAF7 CREB1 FGF2 TP53 APH1A NCSTN GMNN RBL1 HES1 HES5 E2F5 CSNK1A1 DNM1 H3-3A DEPTOR CDK6 CDK4 NOTCH1 PSENEN BACE1 SPRY2 HIP1 SIRT1 MAPT FOXO1-1 EIF2B5 DYRK1A RPTOR NFATC1 TSC2 DNER MLST8 NEUROG2 RBL2 AMPH MTOR TSC1 LIN54 LIN52 GSK3B RAD54L2 LIN37 LIN9 TFAP4 AKT1S1 RBBP4 CRY2 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260910%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K7 MEF2A MAPK3 MAPK7 PRKG1 MAP2K4 MAPK14 IKBKB PDPK1 IKBKG CHUK EGF FGF2 TNF HDAC4 HDAC5 HDAC9 HDAC7 NRG1 IGF1 CDK9 CALM1 MAP3K14 PRKCA PPP3CA PRKD1 PLA2G2A-1 CAMK2D MAPK8 CDK7 NPPA NFATC2 MAP4K1 TNFRSF1A MAP2K7 MAP2K6 MAP2K3 MAP3K1 TGFBR1-1 RAF1 FGFR2 AKT2 AKT1 MTOR MAP2K5 GSK3B LOC118142757;GUCA1A TGFB1 IKBKE MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis SRD5A2 AKR1D1 CYP17A1 HSD3B1;HSD3B2 CYP11A1 CYP21A2 SRD5A1 IL18 SIGNALING%WIKIPATHWAYS_20260910%WP4754%HOMO SAPIENS IL18 signaling TRAF6 MAP3K7 MEF2A MAPK9 MAPK3 PRKAA1 PRKCD IKBKB CTNNB1 CHUK RPS6KB1 IRF1 RELA IL18R1 NFKBIA CASP3 CEBPB IL18 TICAM2 SP1 NCF1 CFLAR PTEN TNF TP53 CYCS-1 IL37 IRAK1 BID GRIN2B NFATC4 PRKCB NOX1 PRKCA MYD88 CASP8 FAS BAX ELAVL1 PARP1 TNFRSF1A MAP2K7 NCF2 ACACB IL18RAP LCK HSPB1 FASLG GSK3B PIK3R1 GATA1 IMP3 CSN2-1 SLC12A3 NFKB1 MAPK1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260910%WP4022%HOMO SAPIENS Pyrimidine metabolism TK1 POLR3B ENTPD3 POLR1A NME3 POLR2C POLR3D CTPS2 POLR1B CTPS1 POLE2 POLR3E DCTD POLR1D NT5M NME6 CMPK1 POLR1E CMPK2 POLE3 UPRT POLR3H DCTPP1 NME4-1 POLR3K RRM1 DUT UCKL1 DHODH NME2 UCK1 POLA1 RRM2-1 PRIM2 PRIM1 RRM2B POLA2 ENPP3 NME7 POLR2A TYMS ENTPD1 DTYMK NME1 POLR1C DCK POLE POLR2D POLR2L DPYS CAD UPB1 POLR1F TYMP NT5C POLR1H POLR3GL TK2 POLD3 POLR3A UMPS POLD4 POLR3C POLR3F DPYD POLR3G POLD1 POLD2 ENPP1 POLR2B POLR2E POLR2G POLR2H POLR2I PNPT1 CDA UPP1 POLE4 POLR2J;POLR2J2;POLR2J3 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260910%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling MYC PDHA1 LDHA TSC2 RXRA IL12A VDR HK3 CD86 AKT1 MTOR PFKFB4 CD80 TSC1 HLA-DRA GSK3B RELA PRKAA2 PIK3CA CYP24A1 IL10 IL2 SIGNALING%WIKIPATHWAYS_20260910%WP49%HOMO SAPIENS IL2 signaling RPS6KB2 IL2RA IL2RB MAPK3 JAK1 STAT1 HRAS STAT3 PTPN11 NMI JAK3 GAB2 MAPT RPS6KB1 CBL GRB2 SOS1 STAT5A STAT5B SYK CRKL SHC1-1 RAF1 LCK IL2 FYN FOXO3 AKT1 IL2RG PTK2B CISH RPS6 PIK3R1 SOCS3 MAP2K2;MAP2K1 MAPK1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260910%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly H4C6 DAXX ATRX H4-16 CHAF1B H2BC15;H2BC3;H2BC11;H2BC12 CHAF1A RBBP4 HIRA SMIM40 H4C1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260910%WP5087%HOMO SAPIENS Pleural mesothelioma PPARGC1A FGF21 ACTG1 RHEB PRKAA2 PRKAG1 PRKAG2 EGF FN1 PRKAG3 AREG FOSL1 CCND1 MYC PRKAB2 PRKAB1 STK38L TNIK SELE PDGFB RPS6KA5 FGF2 ACTB-1 GABPA IL34 MKNK1 MKNK2 MAP3K3 CXCL2;CXCL3;CXCL1-1 IGF1 IL1B MAPK8 MMP3 FZD1 MMP14 LGALS9C;LGALS9;LGALS9B FZD3 MEF2D WNT3A WNT5A WNT7A WNT3 LRP6 AKT2 AKT3 AKT1 MTOR MAP3K6 GSK3B MAP2K2;MAP2K1 EPHA2 MAPK1 MINK1 ADAMTS1 PDGFD MAPK3 DKK1 PDGFC JAK1 NGFR MAP2K4 MAP3K2 STAT1 SOST SLC7A5 IL6 IGF1R RPS6KB1 FRAT2 GRB2 CSNK2A2 SOS1 SFRP4 CSNK2B VEGFB SHC1-1 IL10 VEGFD TCF7 DVL1 DVL2 KITLG FGF20 DVL3 FGF23 FGF22 FGF17 TNNT1 HMGB1-1 SP1 PDGFRA FGF19 FLT4 COL4A2 PTEN COL4A1 COL4A4 FZD10 COL4A6 FGF1 CSF1R AXIN1 CSNK2A1;CSNK2A3 FGF3 FGF4 SLC3A2 FGF5 EFNA4 LEF1 EGFR FGF6 FGF7 FGF8 FGF9 EFNA1 BAK1 EFNA3 EFNA2 FGF14 TCF7L2 TCF7L1 CSNK1A1 WNT5B APC RPS6KB2 FGF13 FGF12 ACTC1;ACTG2 FGF11 KMT2C LIMD1 LAMC3 STK3 SAV1 LAMC2 YAP1-1 LAMC1 TEAD1 MAP4K3 TEAD3 MAP4K4 WNT6 TEAD4 WNT1 MAP4K1 WNT2 MAP4K2 WNT4 NGF MST1 WNT10B LATS1 ACTA1 WNT10A SETD5 FZD2 CXCL12 LAMA5 FZD5 LAMA2 LAMA1 FZD7 LAMA4 LAMA3 FZD6 FZD9 AJUBA FZD8 FGF18 FGFR4 EIF4B SETDB1 FGFR3 ANGPT4 FGFR2 EED LAMB3 FGF10 FGFR1 LAMB2 PDK1 WNT2B LAMB1 PIK3CD PIK3CB PIK3CG TEK CDKN2A NTRK2 WNT16 PIK3CA FLT1 FOXM1 RASSF1 LRP5 PGF MAPK9 WNT11 MAPK7 WDR5 WNT7B MAPK14 BTRC ASXL1 BAP1 MAPK10 MOB1A;MOB1B CTNNB1 LATS2 CDKN1A BRCA1 BBC3 NTF4 FLT3LG OGT-1 CCND3 CCND2 RNF2 MAX CD47 RASSF5 CREB1 CCNE1 TP53 MDM2-2 CYCS-1 SOX17 CER1 SERPINF1 E2F1 SFRP2 SFRP5 CTBP2 PORCN KREMEN1 SENP2 CXXC4 CDK4 CDK2 WIF1 NOTUM BAX ATM CDK7 FOXO1-1 INS;INS-IGF2 FLT3 CCL5 CD274 CCL13;CCL2 TGFB1 NFKB1 CXCL10 CSF3 CSF2 NTRK1 PLAU CCN2 HGF MMP2 MMP9 PDGFA TGFA CCL4L2;CCL4L1;CCL4 TERT CSF1 CASP1 NLRP3 VEGFA MAD2L1 IGF2 HIF1A LIN28B HRAS NF2 MET PAK5 COL4A3 COL4A5 NTF3 CHD8 RING1 HMGN1 RBBP4 CXCL5;CXCL6 PRKAA1 ATF2 ELK1 ATG13 DKK2 KDR DKK4 ULK2 ULK1 PDGFRB ACTA2 BARD1 SFRP1 KIT WWC1 CTBP1 RYK-1 ROR1 ROR2 PLCB4 RPS6KA3 RPS6KA1 MAP3K9 MAP2K7 MAP3K4 MAP2K6 MAP2K3 JUN MAP3K1 DDIT3 BCL2 MAP3K10 RAF1 MAP3K11 YY1 FABP4 MAP3K5 CDH9 AMOT CDH7 ITPR3 CDH5 CDH4 CDH3 AGER CDH20 CDH22 BTC CDH24 CDH10 HBEGF CDH11 CDH12 CDH13 CDH15 CDH17 CDH18 VGLL4 PHC1 TPTEP2-CSNK1E;CSNK1E CDH19 PRSS23 MCU DSC3 BAG2 MDK RASSF2 RASSF3 RB1CC1 RASSF4 TRAF2 RASSF6 BECN1 HCFC1 EFNA5 CTHRC1 BUB1B-PAK6;PAK6 MAP2K5 CDH8 PTK2 ITGB1 ITGB4 ITGB3 ITGB2 ITGAV PODXL ITGA4 KIF23 ITGA3 ITGA2 ITGA1 ITGA6 MAD1L1 SRC PAK1 CUL1 PAK3 PAK2 PAK4 YWHAB UHRF1 IDO1 MAPKAPK2 EZH2 WWTR1 MDM4 BDNF RASSF7 TEAD2 CDH1 CTNNA1 CTNNA3 CTNNA2 TSC2 RPS6 SETD2 EIF4EBP1 ATF3 KDM6A CDH6 CIT CDH2 CDH16 INSR SPARC MCL1 SLC2A1 DEPTOR BMI1 TELO2 CD44 EIF4G1 TTI1 SUZ12 PIGF RPTOR MLST8 ANGPT2 ANGPT1 TSC1 VEGFC NDRG1 AKT1S1 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260910%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression RAF1 EIF4EBP1 MAP3K11 PBK MAPK3 PRKAA1 TSC2 PIK3R3 PIK3CD PIK3CB AKT1 MTOR MAP3K5 TSC1 EIF4E MKNK1 MKNK2 MAP2K6 MAP2K3 PIK3R2 PIK3R1 PIK3CA MAP2K2;MAP2K1 MAPK1 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260910%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 INSR NRIP1 MAPK8 RXRA CREB1 PPARGC1A CEBPD TNF LEP PCK2 IL6 CEBPA IRS1 ADIPOQ IRS2 FOXO1-1 NR3C1 LPIN1 PPARG CEBPB AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260910%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma AGER PINK1 HMGB1-1 STAT3 PRKN TP53 NFE2L2 MDM2-2 KRAS MAP1LC3B2;MAP1LC3B-1 IPO8 TFEB VMP1 SQSTM1 BECN1 MITF NFKB1 SHOC2 ATG7 TFE3 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260910%WP465%HOMO SAPIENS Tryptophan metabolism IL4I1 IDO1 HADH TPH1 ECHS1 STAT1 ACAT1 GCDH ALDH2 CYP1A1 DLD AOC1 TPH2 ALDH8A1 AOX1 AANAT AHR DDC MAOA GOT2-1 AADAT HAAO ASMT ACMSD INMT KMO CAT TDO2 KYNU AFMID KYAT3 KYAT1 IDO2 FANCONI ANEMIA%WIKIPATHWAYS_20260910%WP5465%HOMO SAPIENS Fanconi anemia BRIP1 RAD50 MCM2 FANCI RAD51 ERCC4 MEN1 FANCM FANCL UBE2T FANCA ERCC1 FANCC FANCE PALB2 FANCG SLX4 FANCF ATM ATR MRE11 BRCA1 RFWD3-2 DCLRE1B UHRF2 CTDP1 NBN RAD51C FAAP24 PTEN FANCD2 FAN1 CEBPD BRCA2 SMARCA4 LOC105377022;FANCB XRCC2 USP1 FAAP100 UHRF1 REV1 EGFR HSP90B1 CENPX CENPS-CORT;CORT;CENPS MAD2L2 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260910%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members CREBBP MAVS BTRC PARP1 IKBKB EP300 PARP14 IKBKG CHUK SKP1 NFKBIA ZC3HAV1 TIPARP TFPI2 PARP16 CUL1 PARP12 CLDN6 PARP10 ERN1 GSK3B EIF2AK3 RBX1 RELB TBK1 NFKB2 DDX58 MAP3K14 EGF EGFR SIGNALING%WIKIPATHWAYS_20260910%WP437%HOMO SAPIENS EGF EGFR signaling MAPK9 MAPK7 MAPK4 MAPK14 VAV3 ELK1 PDPK1 GAB2 VAV2 FOS GJA1 DOK2 CBL INPP5D CRK STAT5A STAT5B JUND EGF FOXO4 ROCK1 RIN1 SRC CDC42 PAK1 CSK ERBB2 RALGDS CREB1 RPS6KA5 BCAR1 PLD2 AP2A1 AP2M1 ABL1 RALB E2F1 ATXN2 RICTOR MAP3K3 DNM1 RASA1 AP2B1 ELK4 STXBP1 MAPK8 SH3GL2 SPRY2 AP2S1 RPS6KA3 RPS6KA2 RPS6KA1 MAP3K4 FOXO1-1 JUN MAP3K1 RAF1 NDUFA13 MEF2D TNK2 PTK6 INPPL1 AKT1 CBLC MTOR PIAS3 PLCE1 PIK3R2 FOSB PIK3R1 PXDN MAP2K2;MAP2K1 SYNJ1 MAPK1 RAC1 JAK2 EIF4EBP1 CBLB MEF2A NCK2 ARF6 JAK1 MAP3K2 STAT1 PRKCD STAT3 GAB1 PTPN11 RAB5A VAV1 NEDD4 RPS6KB1 LIMK2 GRB2 PLD1 SOS1 GRB10 SHC1-1 ERRFI1 PLSCR1 USP8 USP6NL PEBP1 CFL1 EPS8 STAMBP STAM2 SP1 IQSEC1 SH3KBP1 EPS15 EPS15L1 PTEN ASAP1 REPS2 PTPN12 ITCH NCOA3 ARHGEF1 SOS2 PTK2B IQGAP1 EGFR MEF2C PRKCI EPN1 PRKCB SH3GL3 PRKCA ABI1 PLCG1 CAMK2A PRKCZ HRAS STAM MAP4K1 RALBP1-1 RALA-1 KRAS NCK1 CRKL PTPN5 STMN1 ATF1 NOS3 HGS RAP1A MAP2K5 PIK3C2B PCNA CAV2 PTPRR CAV1 BRAF PTK2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260910%WP4666%HOMO SAPIENS Hepatitis B infection IRF3 MAPK9 DDX3X-1 MAVS MAPK14 ATF2 MAPK12 ELK1 MAPK13 IKBKB MAPK10 EP300 MAPK11 JAK3 CHUK CDKN1A FOS RELA CASP9 STAT5A STAT5B EGR3 CASP3 SRC MYC APAF1 DDB2 VDAC3 CREB1 TNF ATF4 IFNB1-4 YWHAB YWHAQ CYCS-1 IRAK1 BID TAB2 TAB1 MYD88 MAPK8 CASP8 FAS BAX FADD TICAM1 MAP2K7 MAP2K6 MAP2K3 JUN MAP3K1 TGFBR1-1 BCL2 CREB3L2 RAF1 ATP6AP1 DDB1 STAT2 AKT2 AKT3 AKT1 IFNAR1 STAT6 PIK3R2 TGFB2 PIK3R1 TGFB1 YWHAZ TGFB3 IRAK4 NFKB1 MAP2K2;MAP2K1 MAPK1 TGFBR2 JAK2 TRAF6 MAP3K7 MAPK3 JAK1 MAP2K4 CREBBP STAT1 BAD STAT3 TYK2 IKBKG SLC10A1 IL6 CREB3L3 GRB2 CREB3L4 CREB3L1 MMP9 SOS1 CXCL8 ATF6B TICAM2 TIRAP EGR2 TLR4 TLR3 HSPG2 SOS2 PTK2B PRKCG IRF7 NFATC3 NFATC4 PRKCB PRKCA NRAS PIK3R3 HRAS NFATC2 KRAS SMAD4 CREB5 TRAF3 STAT4 SMAD2;SMAD3 ARAF NFATC1 BIRC5 TLR2 PIK3CD PIK3CB FASLG PCNA IFIH1 CREB3 TBK1 BRAF CASP10 PIK3CA IKBKE DDX58 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260910%WP3929%HOMO SAPIENS Chemokine signaling CCR9 ADCY8 WAS VAV3 IKBKB JAK3 CHUK VAV2 CCL27 CCL26 RELA CRK STAT5B XCL1;XCL2 NFKBIA ROCK1 ROCK2 PRKACB-1 CDC42 PAK1 CCR8 CSK CCR6 PF4;PF4V1-1 CX3CR1 GRK2 GNAI3 RASGRP2 GNAI2 CCL1 CXCR6 BCAR1 CXCL13 CCL20 GNB5 CCL25 CCL24 CXCR5 ADCY1 CCL19 CXCL2;CXCL3;CXCL1-1 TIAM2 PARD3 CCL21 CXCL11 WASL PLCB3 PLCB4 CCL17 PLCB1 CCL22 PLCB2 CX3CL1 CCL23;CCL15 RAF1 STAT2 GRK1 CCL5 AKT2 AKT3 AKT1 FGR GRK6 GSK3B PIK3R2 PIK3R1 NFKB1 MAP2K2;MAP2K1 MAPK1 RAC1 CXCL10 JAK2 GNG10 NFKBIB MAPK3 GNG13 GRK5 STAT1 GRK4 PRKCD STAT3 GNGT1 CCR3 CCR2 IKBKG VAV1 ITK ARRB1 ARRB2 HCK GRB2 CCL28 LYN SOS1 CCL3L1;CCL3L3;CCL3;CCL18 ADCY4 SHC4 ADCY2 SHC1-1 SHC2 CCL11 ADCY7 ADCY6 CCL4L2;CCL4L1;CCL4 ADCY5 NCF1 ADCY9 CXCL14 PREX1 ELMO1 CXCL9 DOCK2 SOS2 PRKX PTK2B PPBP PRKCB GNB2 GNB1 GNB4 GNB3 ADCY3 GNAI1 NRAS PIK3R3 CCR10 PRKCZ HRAS PIK3R5 CCR1 XCR1 KRAS CXCR4 CXCL12 CRKL GNG2 GNG5 CCR7 GNG4 GNG8 TIAM1 CCR4 FOXO3 PIK3CD SHC3 PIK3CB PXN RAP1B PIK3CG RAP1A BRAF CXCR3 PTK2 PIK3CA CXCR2 CXCL5;CXCL6 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260910%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling CCK RYR3 RYR2 GNAI1 CCKBR DAGLA GNAQ PLCB1 RYR1 CD38 CNR1 TRPC1 ITPR1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260910%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2-2 EPHX2 BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260910%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY AKT1 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260910%WP3958%HOMO SAPIENS GPR40 role in insulin secretion FFAR1 GNA11 PLCG2 PLCG1 PKD1 PLCB3 PLCH1 PLCD3 PLCD1 PLCB1 PLCL1 PLCB2 PLCZ1 PLCE1 ITPR3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260910%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells PRKCA RPS6KB2 EIF4EBP1 MAPK9 MAPK3 MAP2K4 MAPK8 PIK3R3 PRKCD MAPK14 MAPK10 EIF4G1 RPS6KA2 RPS6KA1 PDCD4 EIF4A2 MAP2K7 EIF4E RPS6KB1 MAP2K6 MAP2K3 RPTOR EIF4G3 PRKACA-1 EIF4B RPS6KA5 PDK1 AKT2 AKT3 PIK3CB AKT1 MTOR PIK3CG RPS6KA4 CSNK2A1;CSNK2A3 MAP2K5 PIM2 PIK3R2 RPS6 PIK3R1 PIK3CA PIM1 MAP2K2;MAP2K1 MAPK1 EIF4A1 LIPOPROTEIN METABOLISM IN PERIPHERAL TISSUES%WIKIPATHWAYS_20260910%WP5620%HOMO SAPIENS lipoprotein metabolism in peripheral tissues APOC3 LIPC APOC2 APOA1 PLTP CETP APOE APOB LPL LCAT FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP143%HOMO SAPIENS Fatty acid beta oxidation ACADM HADH ACADS LIPC ACSL6 ACSL5 ECHS1 GPD2 ACAT1 GCDH CPT1A CHKB GK PNPLA2 HADHB-1 DLD ACSS2 ACSL3 CPT1B TPI1 CPT2 LIPE ACSL1 CRAT DECR1 ACADVL ECI1 ACSL4 GK2 LIPF HADHA LPL ACADL SLC25A20 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260910%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders FLAD1 RFK PDSS2 COQ6 COQ2 ETFDH APTX ETFA COQ9 COQ7 SLC52A1;SLC52A2 PDSS1 COQ8A TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260910%WP619%HOMO SAPIENS Type II interferon signaling JAK2 CXCL10 IL1B JAK1 REG1B;REG1A STAT1 PRKCD SPI1 ICAM1 PTPN11 ISG15 IRF2 IRF1 NOS2 IFNGR1 STAT2 IFNGR2 IFNG TAP1 CIITA IFNB1-4 OAS1 IRF9 CXCL9 CYBB IRF4 SOCS1 IRF8 PSMB9 EIF2AK2 IFIT2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SOCS3 GBP2;GBP3;GBP1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260910%WP4747%HOMO SAPIENS Netrin UNC5B signaling CDH5 MAPK3 NTN4 ROBO4 NTN3 ALPL COL1A1 MAPK14 ICAM1 CCN2 PTPN11 INPP5D CASP3 IL10 SRC VCAM1 IL1A SELE KDR TNF TP53 ARHGEF12 PTK2B DAPK1-1 RGMA NTN1 UNC5B CIP2A PRKCA RLF PLEKHH1 NEO1 PPP1CA YAP1-1 RHOA DCSTAMP JUN RAF1 PTPA FYN AKT1 CCL13;CCL2 MYF5 PIK3CA PTK2 PPP2R1B MAP2K2;MAP2K1 AGAP2 MAPK1 ITGB4 RAC1 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer EIF4EBP1 NRAS BAD PIK3R3 HRAS CDKN1B RHEB RB1CC1 KRAS FOXO1-1 GRB10 FOXO4 RPTOR ATG13 TSC2 MAPKAP1 NOS3 MLST8 PDK1 ULK1 PTEN FOXO3 PIK3CB AKT1 MTOR PIK3CG GSK3B PIK3R2 RICTOR PIK3R1 PIK3CA TFEB MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260910%WP4318%HOMO SAPIENS Mitochondrial fission and fusion MTFP1 BAX SH3GL2 BNIP3 PHB DNM1L MIB1 MFN1 MFN2 PLD1 BCL2L1 FIS1 OPA1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260910%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome JAK2 C3-1 RABGEF1 CD19 NFATC2IP TUFM ATXN2L SPNS1 CD81 RAB5A NFATC2 VAV2 ATP2A1 CR2 TRAF1 GRB2 TRAF2 IFITM3;IFITM2;IFITM1 INSR IL4 KDR SH2B1 LAT CD82 PRMT1 RABEP2 MPL RAB4A APOPTOSIS%WIKIPATHWAYS_20260910%WP254%HOMO SAPIENS Apoptosis IRF3 NFKBIB PRF1 MAP2K4 BAD CASP5;CASP4 IKBKB MAPK10 IKBKG CHUK IRF2 IGF1R TP63 IRF1 BBC3 RELA CASP9 TRAF2 BCL2L1 NFKBIA CASP3 MYC HRK APAF1 BOK BIRC2 BIRC3 TNFRSF25 DIABLO-1 CFLAR TNF TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 BCL2L2 MDM2-2 CYCS-1 CASP7 CASP1 PMAIP1 CASP6 CASP2 IRF7 BAK1 BID MCL1 IGF1 SCAF11 IGF2 CASP8 FAS BAX TRADD XIAP RIPK1 FADD CRADD TNFRSF1A HELLS LTA TRAF1 TNFRSF21 JUN GZMH;GZMB-1 MAP3K1 TRAF3 BCL2 DFFB DFFA NFKBIE TNFRSF1B BIRC5 IRF6 BCL2L11 BNIP3L AKT1 TP73 FASLG IRF4 IRF5 CDKN2A CASP10 PIK3R1 TNFSF10 NFKB1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260910%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IL18 MYD88 SELENBP1 IL1B IL1R1 TLR1 IFNG TIMP1 HBEGF TLR2 F2R TIMP2 ICAM1 CCR3 CCL13;CCL2 PLA2G7 FCER1A IRAK1 F2 NLRP3 MMP9 PIK3CA S100A9 NFKB1 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260910%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 JAK2 PTPN1 NFIB PNCK ERBB3 DLGAP4 ERBB4 TTC9 GJB2 GAL HDGFL2 EIF4G1 CHUK TPM3 CEBPA EIF4E TNFSF11 USF1 NR3C1 STAT5A STAT5B BCL2L1 CEBPB ORAI1 ESR1 ELF5 TFPI2 CCND1 MYC YY1 CLDN6 NFIX TNFRSF11A ERBB2 ESR2 PGR PRL EGFR NFIA CAV1 NFIC PRLR ATP2C2 NRG1 USF2 CSN2-1 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260910%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SLIT2 ROBO4 KDR VEGFA SRC RAC1 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260910%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP1 CALM1 ESR1 SP3 KCNN3 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260910%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 CTNNB1 RB1 CHUK CSNK1D MRE11 RHEB BRCA1 DAG1 CASP9 CDC25B CHEK2 CASP3 ESR1 CHEK1 MAX FOSL1 CDC42 CCND1 PAK1 MYC DHTKD1 RHO CDC25A TFPI PLK1 CREB1 FAU RASGRP3 TP53 MDM2-2 BLM ABL1 BARD1 E2F1 NOXA1 MSH6 BID GSK3A MSH2 ERAL1 UBE2F GADD45A EDAR MYT1 TAB1 JAKMIP1 PML RAD50 RAD51 CDK4 CDK2 CASP8 BAX ATM TRADD CDK7 ATR FADD CERK IRS1 GRN FOXO1-1 JUN TGFBR1-1 BCL2 CDH1 TSC2 SELENOK RAD54L PIAS1 SMARCA4 HIPK2 AKT1 MTOR FOSL2 HDAC1 PIK3R2 AURKA NFKB1 MAP3K13 MAPK1 RAC1 TGFBR2 ZMIZ1 CYP19A1 JAK1 AR STAT1 BAD PKIA MMP1 ANXA1 RRAS NUP85 TPR STK11 SP1 SMAD7 PTEN BRCA2 WEE1 PHB XRCC3 NCOA3 AHR EGFR VEGFA PPP4R3A BAK1 PPP4R3B GDI1 MYCBP2 BACH1 NF1 NAB1 SIRT1 MAP3K7CL ZMYND8-1 RALA-1 ALKBH1 RALGAPA1 CCNB1IP1 SMAD1 PLK3 KRAS SMAD4 FER PIGR USP38 IMPA1 ZNF655 RASGEF1A DCAKD ITPKC USP15 USP16 SMAD2;SMAD3 USP21 FILIP1 ARAF ATF1 BMPR1A BMPR2 HMGCR TSC1 RAP1A RPP38 SMAD6 BRAF ODC1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260910%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders CCND1 GALNT3 DMP1 PHEX CYP27B1 FGF23 SLC34A1 SPP1 FAM20C FGFR3 ALPL FGFR2 KL CDKN1A ENPP1 PTH ROS1 CYP24A1 NFKB1 CYP11B1;CYP11B2 ORAI1 NFKB2 MITOPHAGY%WIKIPATHWAYS_20260910%WP5636%HOMO SAPIENS Mitophagy MAPK9 NLRX1 TOMM40 TOMM70 EIF2S1 MAPK10 ATG9A RAB5A ARIH1 SMURF1 MTX1 TRAF2 TOMM20 CSNK2A2 BCL2L1 OPA1 MITF BECN1 SRC BECN2 AMBRA1 CALCOCO2 USP8 RHOT1 SP1 ULK1 RAB7A ATF4 PRKN BNIP3 PHB2 CSNK2A1;CSNK2A3 E2F1 EIF2AK3 MFN1 MFN2 MARCHF5-1 NBR1 ATG9B FKBP8 SQSTM1 RABGEF1 BCL2L13 MAPK8 PINK1 HIF1A VCP-1 KRAS JUN USP15 TFE3 PGAM5 CITED2 FUNDC1 USP30 OPTN-1 MUL1 TAX1BP1 RAB5B RAB7B RAB5C SAMM50 FOXO3 TBC1D17 CCZ1;CCZ1B SIAH1 BNIP3L TBC1D15 HUWE1 TOMM7 MAP1LC3A AMFR TBK1 TFEB FIS1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260910%WP5234%HOMO SAPIENS Bardet Biedl syndrome BBS4 ZIC2 BBS9 CRX LCA5 BBS7 CEP290 CLUAP1 BBS5 RP2 TMEM216 CEP104 ARL3 ARL13B TMEM67 INPP5E PDE6D NPHP3 NEK8 NEK1 BBS2 BBS1 IFT172 MKS1 IFT74 TTC8 CFAP410 MAK EVC2 CEP41 TRAF3IP1 TTC21B GLI2 KIF7 PKHD1 EVC DCDC2 C8orf37 GPR161 WDPCP ARL6 ARNTL BBIP1 INVS USP9X EFHC1 SMO PKD2 TMEM107 MKKS PKD1L1 BBS10 BBS12 CILK1 PCARE RAB23 SCLT1 CNGA1 TRIM32 DYNC2H1 DYNC2I2 LZTFL1 DYNC2I1 CNGB1 PTCH1 IFT140 DYNLT2B WDR19 IFT122 IFT80 WDR35 FUZ DYNC2LI1 IFT43 IFT81 IFT27 PKD1 SCAPER GLI3 IFT52 IFT57 IQCB1 FLCN EFHC2 CEP164 OCRL MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260910%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission JAK2 GABRA1 GABRP AP2B1 GABRA6 GABRA5 GABRA4 NGFR GABRA3 GABRG1 PLCG1 PIK3R3 STAT3 RHOA BDNF SHC1-1 ROCK1 SLC12A5 CREM CREB1 PTEN AP2A1 PIK3CB AP2A2 PIK3CG GABRB3 GABRB2 NTRK2 GABRB1 PIK3R2 PIK3R1 PIK3CA GABRG3;GABRG2 GABRE GABRD GABRQ GABRA2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260910%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system ISG15 EP300 CTNNB1 CDC20 FUS ERG G3BP1 HSPA8 VIM GRK2 ITIH4 PARK7 SHH GSK3A SNCAIP HDAC6 MYD88 TUBA1C PPP1CA MAPK8 BAX CTTN MAPT TUBB3;TUBB6 ACTR1A BDNF NR3C1 EP400 HDAC11 BCL2 RAD23B PROM1 PRDX2 AKT1 MAP3K5 CYBB MAP1LC3A TUBA4A SIRT2 MDH1 GSK3B AURKA KAT5 NDUFV1 MAPK1 RAC1 MAPK3 SGK3;C8orf44-SGK3 MIF TUBA3E;TUBA3C-1 HSF1 TUBB4A;TUBB;TUBB8B;TUBB8 PRDX1 SGK1-1 CSNK2A2 STUB1 CSNK2B APOE VHL ATP13A2 SNCA DCTN1 SOD1 RHOT1 SP1 UBD SMAD7 PRKN HTT HDAC9 PTK2B DNAJA1-1 EGFR BBIP1 SQSTM1 PRKCE APC POU5F1;POU5F1B GRIA1 CFTR HIF1A GRIA2 PRKCZ VCP-1 HSP90AA1 ELP3 DLG2 DLG4 DYNC1I2 MAPRE1-1 SMAD2;SMAD3 TPPP MYH9 FOXP3 BIRC5 OPTN-1 MAP1B PXN KALRN XRCC6 ATXN3 HSPB1 CCDC141 HSPA4 CNOT6 NEDD9 MIIP ELP1 TARDBP ARID3A GARS1 MTHFR DEFICIENCY%WIKIPATHWAYS_20260910%WP4288%HOMO SAPIENS MTHFR deficiency GRIN1 DNMT1 MTHFR COMT HNMT DNMT3A CHKA DNMT3B MARS1 BHMT CYCS-1 GRIN2A NDUFAF7 CHDH PEMT ASMT CASP9 CHPT1 ALDH7A1 GRIN2D PCYT1A EHMT2 CASP3 EHMT1 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260910%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease DGUOK C4orf54 BEND6 DLL4 EFL1 SHCBP1 MAPK3 IBTK ARHGAP31 EOGT NOTCH1 SBDS NOTCH4 KCNN3 NCF2 BTK ESR1 EIF6 CDC42 COX4I2 NOX3 GTF2I SP1 TLR9 TLR8 NCF1 NCF4 CYBA RBPJ CYBB DOCK6 CYBC1 NFKB1 CXXC5 MAPK1 CHCHD2 RAC1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260910%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance JAK2 IL6R EIF4EBP1 NRG2 PDGFD MAPK3 JAK1 PDGFC PLCG2 ERBB3 BAD STAT3 GAB1 PDPK1 HGF IL6 IGF1R RRAS RPS6KB1 GRB2 SOS1 BCL2L1 SHC4 EGF SHC1-1 SHC2 SRC GAS6 PDGFA CCND1 TGFA MYC ERBB2 KDR PDGFRA PDGFB PDGFRB PTEN FGF2 SOS2 EGFR VEGFA PRKCG NRG1 IGF1 PRKCB PRKCA RPS6KB2 NRAS PLCG1 PIK3R3 BAX HRAS NF1 EIF4E KRAS EIF4E2 BCL2 RAF1 MET AXL ARAF FGFR3 FGFR2 FOXO3 PIK3CD AKT2 RRAS2 BCL2L11 AKT3 MRAS PIK3CB AKT1 SHC3 MTOR GSK3B RPS6 PIK3R2 BRAF PIK3CA PIK3R1 MAP2K2;MAP2K1 MAPK1 AMINO ACID METABOLISM%WIKIPATHWAYS_20260910%WP3925%HOMO SAPIENS Amino acid metabolism PC CPS1 SMS EHHADH-1 LDHA SDS HIBADH PKM TPO OTC MCCC1 PPM1L IARS1 VARS1 AOC3 ACAA1-1 CBS;CBSL AUH SRM MMUT ACO2 G6PC2 BCAT1 DLD HIBCH SDHA MARS2 PDHX FH TAT DLST HAL FAH GPT2 PDHA1 ACLY SUCLG1 LARS2 CTH CS MDH2 PNMT DDC MAOA GOT2-1 ALDH7A1 TDO2 EPRS1 GOT1-1 ACADM HADH GLUL GLS TPH1 FTCD MPST PYCR1 HMGCL BHMT RARS1 ADH4 ADH1C;ADH1B;ADH1A GLUD1;GLUD2 ALDH1A1 IDH1 P4HA2 GSS GSR ALDH18A1 PDK4 DBH ADH5 PCK1 HMGCS2 OGDH GCLM FARSB HNMT CAD ACSS1 TH MDH1 HDC ARG2 ASNS OAT ARG1 WARS1 ODC1 ASS1 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260910%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells SLC2A1 LDHA PKM PFKP HK1 PDK1 PDP1 SLC16A1 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260910%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins ATG2B DEPTOR ATG16L1 VPS11 PKM VPS16 VAMP8 TMEM59 ATG9A LAMTOR1 VPS39 RHEB RPS6KB1 RB1CC1 PRKAA2 VPS33A PPP1R9A APOB CALCOCO2 RPTOR EIF4B ATG13 OPTN-1 LARP1-1 TAX1BP1 MLST8 ULK1 RAB7A AKT1 LAMP2 MTOR VPS41 ATG3 MAP1LC3B2;MAP1LC3B-1 GABARAPL2 RPS6 ATG12-1 NBR1 AKT1S1 SQSTM1 ATG4A ATG7 ATG5 VPS18 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260910%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling ILK DEPTOR PPARGC1A IGFBP5 TNFRSF1A IRS1 IGF1R EIF4E RPS6KB1 TNFSF9 ACVR2B PLD1 SMAD2;SMAD3 EIF2B2 RPTOR PRKAB1 NEB MAPKAP1 FBXO32 MLST8 PDK1 PTEN AKT1 MSTN MTOR PIK3CG MAP1LC3A TRIM63 GSK3B RICTOR ITGB1 IGF1 AKT1S1 NFKB1 WASL 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome MTMR8 MTMR9 MAPK3 MTMR6 MEPE MTMR7 CTSB TBX5 SLBP TNKS MCRS1 CSTA PINX1 GATA4 RP1L1 HEPACAM2 CTNNB1 C8orf74 DEFB135 CGAS CLDN23-1 FDFT1 MFHAS1 FAM167A BMP1 XKR6 SLC35G4;SLC35G5;SLC35G3;SLC35G6 SOX7 SLC2A4 RAF1 TERF1-1 TERT NUMA1 PPP1R3B SGPL1 TLR2 BLK ERI1 TLR4 NKX6-1 AXIN1 HSPD1 S100A10 CTSD NEIL2 PDX1 MAPK1 MSRA GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260910%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes GJA1 PTBP2 HCN4 ERG HAND2 KCNE1;KCNE1B HCN2 KCNQ1 IGF1 KCNJ2 HDAC4 SRF EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260910%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer DLL1 DLL3 DLL4 WNT11 WNT7B FOXC2 MAPK14 MAPK12 MAPK13 MAPK11 LATS2 CTNNB1 MPP5 JUP CLDN4 CLDN23-1 CLDN5 CLDN3 ITGA5 PDCD6 CDKL2 CLDN9 CLDN8 FN1 CLDN7 PKP1 EIF5A2 CLDN20 PAK1 CLDN22;CLDN24-1 CLDN10 CLDN15 PKP2 CLDN14 CLDN12 CLDN19 ID2-1 STRAP CLDN18 CLDN17 CLDN16 CRB3 TP53 CLDN11 MAPK8 ZEB1 EZH2 TMPRSS4 MAP2K6 MAP2K3 TGFBR1-1 RAF1 CDH1 FZD1 FZD3 MEF2D WNT3A WNT5A MMP15 WNT7A PROX1 WNT3 LRP6 AKT2 AKT3 AKT1 GSK3B CTDSP1 PIK3R2 TGFB2 PIK3R1 TGFB1 OCLN-1 TGFB3 MAP2K2;MAP2K1 MAPK1 TGFBR2 TRAF6 FOXQ1 MAPK3 MAP2K4 NR2C2 FMNL2 DSP CDH2 SNAI1 SNAI2 MMP2 GRB2 MMP9 SOS1 SHC1-1 NRP2 CLDN6 CLDN2 COL4A2 COL4A1 SPARC GDF15 COL4A4 FZD10 COL4A6 RBPJ NUBPL SOS2 VTN WNT5B NOTCH2 NOTCH3 NOTCH1 NOTCH4 HIF1A PIK3R3 HRAS WNT6 WNT1 WNT2 WNT4 JAG2 TJP1 WNT10B WNT10A ID1 KRAS SMAD4 FZD2 CLDN1 JAG1 FZD5 FZD4 FZD7 FZD6 FZD9 SUZ12 SMAD2;SMAD3 FZD8 COL4A3 COL4A5 EED TUSC3 WNT2B PKD1 PIK3CD TWIST2 PIK3CB ZEB2 WNT9B WNT9A WNT16 PIK3CA FOXM1 RBBP4 LRP5 WNT8A WNT8B DLK1 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260910%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway MAPK9 MAPK3 JAK1 RAC3 STAT1 BAD PRKCD STAT3 DUSP6 IKBKB MAPK10 RB1 IKBKG CHUK CDKN1A RPS6KB1 RELA CASP9 PLD1 BCL2L1 EGF CDC42 CCND1 TGFA PAK1 ERBB2 PAK3 PEBP1 PAK2 PAK4 DDB2 RALGDS BRCA2 RIPK4 PLD2 POLK TP53 RALB EGFR E2F1 E2F2 E2F3 VEGFA BAK1 GADD45B GADD45A GADD45G RPS6KB2 CDK6 RAD51 CDK4 MAPK8 PIK3R3 BAX RALBP1-1 RALA-1 KRAS SMAD4 TGFBR1-1 BUB1B-PAK6;PAK6 RAF1 ARHGEF6 SMAD2;SMAD3 ARAF PAK5 PIK3CD AKT2 AKT3 PIK3CB AKT1 MTOR CDKN2A PIK3R2 TGFB2 BRAF PIK3CA PIK3R1 TGFB1 TGFB3 MAP2K2;MAP2K1 NFKB1 MAPK1 RAC1 TGFBR2 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260910%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions ITGAL CD19 STK3 SAV1 YAP1-1 MAPK14 TEAD1 WWTR1 TEAD3 MOB1A;MOB1B TEAD4 LATS2 RHOA MST1 LATS1 FYB1 TEAD2 FOXO1-1 FOXO4 CCR7 STK38L FOXP3 RASSF5 FOXO3 FOXO6 KNSTRN-1 YWHAQ RAB13 FERMT3 RAP1A NDRG1 PRDM1 LPL RAC1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260910%WP2806%HOMO SAPIENS Complement system ITGB3 C3-1 CFP CD19 WAS ICAM1 PROS1 FGB ITGA2 FGA C4BPA ARRB2 C3AR1 LOC110384692;C4A;C4B_2;C4B FGG C5AR2 CR2 FCN2;FCN1 APOA1 PLAUR PLG LRP2 MASP2 MASP1 C5 CFB C1QBP CFD C1S SELPLG IBSP CFI SPP1 C5AR1 SELE CD59 SELP C2 GNAI3 GNAI2 C6 F11 C7 ALB C9 CD55 F10 PTX3 C8A CR1L;CR1 VSIG4 CD93 DCN CFH-3 CFHR1;CFHR2 FCER2 APCS VTN FKBP2 CLEC4M;CD209-2 CSNK1A1 PRKCA FPR1 LAMC1 ICAM2 MBL2-1 F13A1 ADIPOQ F12 ADM SERPING1 LAMA5 ELANE KLKB1 CPN1 CD40 ITGA2B GNA15 PRKACA-1 RPS19 TLR2 LAMB1 PRNP THBS1 CRP FCGR3A;FCGR3B CALR-1 TXN SELL BURN WOUND HEALING%WIKIPATHWAYS_20260910%WP5055%HOMO SAPIENS Burn wound healing KLF4 COL1A1 COL1A2 ICAM1 CD3E MMP1 HGF IL6 SNAI2 MMP2 LGALS1 FBN1 MMP9 EGF CASP3 CXCL8 TNC TIMP1 HMGB1-1 PDGFRB TLR4 TNF IFNB1-4 IL15 TP53 DCN SFRP2 HEXD VEGFA KRT222 PECAM1 CXCL2;CXCL3;CXCL1-1 S100A6 SCEL S100A11 S100A9 AMBP NOX4 SLURP1 TPT1 CDK16 MYD88 IL1B BAX LIN28A F13A1 ACTA1 MMP28 CXCR4 CXCL12 ACHE FOXE1 BCL2 SMAD2;SMAD3 CHRNA7;CHRFAM7A FGFR4 FGFR3 FGFR2 SERPINH1 FGFR1 FST BRD4 AKT1 CCL13;CCL2 INHBA TGFB2 CXCR2 TGFB3 NFKB1 KRT6B;KRT6C;KRT6A LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2874%HOMO SAPIENS Liver X receptor pathway SREBF1 NR1H3 CYP2B6 CYP7A1 SCD RXRA FASN ABCG8 ABCG5 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260910%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 ING2 SKIL STK3 MECP2 MERTK PRMT5 TEAD1 TEAD3 NF1 TEAD4 LATS2 LATS1 HDAC1 SIN3A SKI TEAD2 SATB2 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260910%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms AGT ACE2 TMPRSS2 ACE AGTR1 MAS1 REN PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260910%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PI4K2B MTMR2 TPTE;TPTE2 MTMR8 PI4KB PI4K2A MTMR6 MTM1 PLCG2 PIP5K1A PLCG1 PIP5K1B PIP4K2A PIP5K1C PIKFYVE PLCB3 PLCB4 PLCD3 PLCD4 PLCD1 IPMK PLCB1 INPP5E PLCB2 INPP4B INPP5D PI4KA PTEN PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 INPP4A PIP4P1 PLCE1 INPP5K PIP4K2B PIK3CA PIP4K2C SACM1L OCRL FIG4 MTMR1 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome CYFIP1 TUBGCP2 NIPA1 TUBGCP5 NIPA2 FMR1 TUBGCP6 TUBGCP3 TUBGCP4 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260910%WP5390%HOMO SAPIENS Pancreatic cancer subtypes SLC2A1 SPRR3 ST6GALNAC1 SERPINB3;SERPINB4-1 KRT20 CTSE LGALS4 TFF3-1 VSIG2 AGR2 AGR3 FAM3D LYZ-1 SPINK4 CDH17 KRT7 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ANXA10 LEMD1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 KRT17 MYO1A GPR87 PRR15L LY6D TFF1 VGLL1 CLRN3 DHRS9 CTSV;CTSL AREG FAM83A TNS4 FGFBP1 REG4 SPRR1A;SPRR1B ANXA8;ANXA8L1 PLA2G10;LOC100652777 S100A2 SCEL TSPAN8 CST6 KRT15 KRT6B;KRT6C;KRT6A LUPUS PATHOGENESIS%WIKIPATHWAYS_20260910%WP5559%HOMO SAPIENS Lupus pathogenesis PDCD1 LOC102723996;ICOSLG TNFRSF13C CD40LG TLR9 TLR7 TLR4 CD86 ICOS CD274 CD80 TNFSF13B IL6 BCR CD28 CD40 IL17A COCAINE METABOLISM%WIKIPATHWAYS_20260910%WP2826%HOMO SAPIENS Cocaine metabolism CES2 BCHE CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TAR SYNDROME%WIKIPATHWAYS_20260910%WP5362%HOMO SAPIENS TAR syndrome PEX19 MTA1 CCAR2 STAT3 CD247 LAMTOR1 CD3D UBE2I FURIN IFNG SLC22A4 EGFR HJV HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD160 DNM1 TNFRSF14 BCL2L13 HDAC2 CFTR RBCK1 SIRT1 AKAP10 FARP2 CXCR4 ANKRD35 HAMP EIF4A3 SLC22A12 SLK SUMO2 PDZK1 GPR89A;GPR89B PEX11B MET CLCN3 SLC9A3R1 LCK MAGOH;MAGOHB BRF1 PYM1 PDZK1IP1 MITD1 FLT3 POLR3GL ZFHX3 POLR3C POLR3F POLR3G PIAS3 ITGA10 ITGB1 DDIT4 NFKB1 TXN GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260910%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCA PRKCQ PPP3CA PRKD1 NFATC1 PPP3CB PPP3CC PRKD3 PRKCD PRKCZ PLCB3 PKN3 ANGPT2 PKN2 PPP3R1 GNAQ PKN1 PRKD2 PRKCG PRKCI PRKCH RCAN1 PRKCB PRKCE EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260910%WP410%HOMO SAPIENS Exercise induced circadian regulation GSTP1 NCOA4 PER2 UGP2 PER1 G0S2 IDI1 H2BC15;H2BC3;H2BC11;H2BC12 GSTM3 SF3A3 GFRA1 KLF9 PSMA4 NCKAP1 TUBB3;TUBB6 PURA CLDN5 CLOCK HLA-DMA CEBPB PPP2CB;PPP2CA NR1D2 UCP3 HSPA8 PPP1R3C PIGF HERPUD1 EIF4G2 DAZAP2 BTG1 AZIN1-2 STBD1 SUMO3 ERC2 ETV6 RBPMS ZFR MYF6 DNAJA1-1 CBX3-1 ARNTL TOB1 QKI CRY2 TAB2 VAPA CRY1 SUMO1 GLYCINE METABOLISM%WIKIPATHWAYS_20260910%WP1495%HOMO SAPIENS Glycine metabolism MTHFR SHMT1 SHMT2 SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260910%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF3 IFNAR2 JAK1 STAT2 STAT1 MAVS TLR3 IFNB1-4 TYK2 IRF9 TICAM1 ACE2 IFNAR1 IFIH1 TBK1 TRAF3 IKBKE DDX58 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260910%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide MYD88 MAP1LC3A TRAF6 IRF3 IFNG TLR9 TLR4 BECN1 TNF NFKB1 IFNB1-4 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260910%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling HK2 MAPK9 LDHA MAPK14 PPARGC1A ELK1 PDPK1 CPT1A CTNNB1 FOS CLDN5 RELA PRKAA2 EGR1 FN1 SRC SIX1 VIM KDR RPS6KA5 PDGFRB TNF IFNB1-4 TP53 MST1R ABL1 ACTA2 CXCL2;CXCL3;CXCL1-1 IL1B MAPK8 ZEB1 PARP1 DUSP4 RPS6KA3 RPS6KA1 ACACA JUN NR4A1 RAF1 CDH1 FZD1 KLK15 AKT1 SLPI MTOR RPS6KA4 CCL13;CCL2 SOCS1 GSK3B RPS6 PIK3R1 TGFB1 OCLN-1 SOCS3 NFKB1 MAP2K2;MAP2K1 MAPK1 CXCL10 MAPK3 CSF3 CSF2 SP7 GAB1 DUSP6 DUSP1 PDCD4 CDH2 IL6 IGF1R SNAI2 RPS6KB1 GRB2 MMP9 SHC1-1 IL10 CXCL8 IBSP PDGFRA COL4A1 PTEN VEGFA PRKCB SLC2A1 PLCG1 MST1 TJP1 WNT10B SMAD1 CLDN1 CRKL NR0B2 SMAD2;SMAD3 SMAD9 SMAD5 FGFR1 ZEB2 HSPB1 NDRG1 PCNA SMAD6 PTK2 FLT1 CXCL5;CXCL6 ITGB1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260910%WP4753%HOMO SAPIENS Nucleotide excision repair CUL4A ERCC3 ERCC4 POLE2 RPA3 ERCC1 POLE3 ERCC2 ERCC8 ERCC6 CUL4B CDK7 MNAT1 CETN2 POLE RFC5 RFC3 RFC4 RFC2 RAD23A ERCC5;BIVM-ERCC5 RAD23B RFC1 DDB1 GTF2H2C;GTF2H2C_2;GTF2H2 DDB2 POLD3 POLD4 CCNH POLD1 POLD2 LIG1 PCNA RBX1 RPA1 GTF2H1 GTF2H3 RPA2 XPA GTF2H4 XPC POLE4 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260910%WP5173%HOMO SAPIENS Disorders of galactose metabolism GBE1 SLC2A2 PYGL GYG2 PGM1 GALT GYS2 GYS1 GALK1 GYG1 AKR1B1 GALE SLC5A1-1 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC42 STAT3 RHOA AMER3 PLEKHB2 MZT2A;MZT2B STMN2 FAM168B CDC27 GPR148 APC ARHGEF4 RAC1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260910%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway ALDH3A1 JUNB IL1B CES3 CAP2 AHRR NCOA1 SERPINB2 MYOF BAX IL12B HSP90AA1 CYP1A2 EP300 CDKN1B SLC7A5 CYP1A1 JUN AIP JUND SRC GSTA3;GSTA5;GSTA1;GSTA2 IL2 NQO1 IFNG IL12A TNF POLK CDC37 UGT1A1;UGT1A6 NFE2L2 CYP1B1 IGFBP1 PTGES3-1 AHR EGFR HES1 TGFB1 ARNT IL17B MGST1 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260910%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway HSPA6 TUBA3E;TUBA3C-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 TUBB2B;TUBB2A STUB1 PSMD8 PSMD9 PSMD6 TUBAL3 PSMD7 PSMD4 PSMD2 SNCA PSMD3 CUL1 HSPA8 PSMD1 PSMC2-1 PSMD5 CCNE1 PRKN PSMD11 PSMD10 UBE2L6 UBE2J2 UBE2J1 CASP1 GPR37 HSPA9 SEPTIN5 UBE2G1 UBE2G2 FBXW7 SNCAIP UBA1 HSPA2 TUBA1C SIAH2 TUBA1A CASK CASP8 TUBB3;TUBB6 TUBB4B PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SIAH1 TUBB1 TUBA4A HSPA1A;HSPA1B HSPA4 RNF19A PSMD12 HSPA5 PSMD14 HSPA14 PSMD13 HSPA1L HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260910%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 ZEB1 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260910%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling DLL1 PSEN1 DLL3 DLL4 MFAP1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 CHUK JAG2 RRAS JAG1 DNER MAML2 MAML1 RBPJ LEF1 HEY1 HES1 DLK2 PSEN2 MFAP2 MAML3 CNTN6 ADAM10 DLK1 METHYLATION PATHWAYS%WIKIPATHWAYS_20260910%WP704%HOMO SAPIENS Methylation pathways TPMT MAT2A PNMT COMT HNMT MAT1A MAT2B INMT NNMT TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260910%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle DLST OGDH SUCLA2 SUCLG2 SUCLG1 IDH2 IDH3A CS MDH2 ACO2 SDHC SDHD DLD SDHA SDHB IDH3G IDH3B FH PDGF PATHWAY%WIKIPATHWAYS_20260910%WP2526%HOMO SAPIENS PDGF pathway RASA1 MAPK3 JAK1 MAP2K4 MAPK8 PLCG1 STAT1 HRAS STAT3 ELK1 PLA2G4A PTPN11 CHUK RHOA VAV1 ARFIP2 VAV2 FOS GRB2 JUN MAP3K1 SOS1 NFKBIA SHC1-1 SRC PDGFA CDC42 RAF1 PAK1 TIAM1 PDGFB PDGFRB PIK3R1 MAP2K2;MAP2K1 NFKB1 MAPK1 SRF WASL RAC1 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260910%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids ASAH2 HIF1A AKT1 MTOR TSC1 S1PR1 S1PR3 CERK IGF1R CERS1 SPHK2 PIK3CA PLD1 NFKB1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260910%WP1601%HOMO SAPIENS Fluoropyrimidine activity TK1 SMUG1 CES2 ABCG2 CES1 CYP2A13;CYP2A6;CYP2A7-1 TYMS ERCC2 RRM1 UCK1 DHFR2;DHFR ABCC3 ABCC4 ABCC5 RRM2-1 SLC29A1 GGH MTHFR DPYS UPB1 TYMP UMPS DPYD TDG TP53 XRCC3 PPAT CDA FPGS SLC22A7 UPP1 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260910%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway SQLE IDI1 CYP51A1 MVK NSDHL SC5D MSMO1 DHCR7 MVD HMGCR HMGCS1-1 PMVK FDFT1 FDPS LSS HEROIN METABOLISM%WIKIPATHWAYS_20260910%WP2645%HOMO SAPIENS Heroin metabolism CES2 BCHE CES1 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260910%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways ACTR3-1 WNT11 MAP2K4 NEFM NEFH ERBB4 ELK1 CTNNB1 CDKN1A CDKN1B CBL GRB2 SOS1 PFN1 STAT5A SHC1-1 FN1 ROCK2 SRC DVL1 TGFA PAK1 MYLK MYC ERBB2 SOD1 ACTR2 CAMK1 FZD10 AXIN1 EGFR DAAM1 MYL1 APC GRIA1 PFN3 MAPK8 PLCG1 RHOA GPX1 ACTA1 FZD2 JUN FZD5 NCK1 FZD4 FZD7 PPP2CB;PPP2CA NEFL FZD6 FZD9 RAF1 FZD8 FZD1 NOS1 FZD3 AKT1 PIK3CG GSK3B WNT16 PTK2 MAP2K2;MAP2K1 MAPK1 PFN2-1 LAC PHE PATHWAY%WIKIPATHWAYS_20260910%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260910%WP5360%HOMO SAPIENS KCNQ2 related epilepsies PRKCA PRKACA-1 CHRM1 ANK3 PPP3CC P2RY1 PLCG2 SCN1B BACE1 KCNQ2 KCNQ3 STX1A CSNK2A1;CSNK2A3 AGTR1 BDKRB2 PPP1R10 AKAP5 ITPR1 CALM1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP5153%HOMO SAPIENS N glycan biosynthesis MGAT4A-1 MAN1A2 GMPPA MAN1A1 ST6GAL1 ST6GAL2 ALG5 DAD1 MAN1B1 GANAB MAN2A2 MAN2A1 MGAT5 MAN1C1 MGAT3 MGAT5B-1 MGAT4C MGAT4D DOLPP1 MGAT4B STT3A DDOST STT3B ALG10;ALG10B B4GALT3 RFT1 RPN2 RPN1 B4GALT2 GPI FUT8 DPM2 MGAT1 DPAGT1 ALG8 ALG9 B4GALT1 ALG6 TUSC3 MPI PMM2 SRD5A3 ALG2 ALG14 ALG3 DOLK MOGS ALG12 ALG1 ALG11 DPM1 GMPPB DPM3 MGAT2 MPDU1 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260910%WP4595%HOMO SAPIENS Urea cycle and associated pathways GOT1-1 GPT CPS1 NOS2 ALDH4A1 LDHB GLS2 ASL NAGS NOS1 SLC25A12 SLC25A13 OTC NOS3 PYCR1 MDH2 GLUD1;GLUD2 MDH1 GOT2-1 OAT ARG1 SLC25A15 FH ASS1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260910%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 ADAM17 AVPR1B CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260910%WP536%HOMO SAPIENS Calcium regulation in cardiac cells ITPR2 ADCY8 ATP2B1 GJA1 RYR1 ORAI1 CASQ1 PRKACB-1 PRKAR2B CACNB1 PRKAR2A CACNB3 PRKAR1B PRKAR1A GNAI3 GNAI2 CAMK1 YWHAE GNB5 YWHAB YWHAQ GNAO1 YWHAH ADCY1 SFN GJA4 CALM1 CALM2 RYR3 CACNA1B CHRM1 CACNA1A PLCB3 ATP2B3 ATP2B2 ADRA1A GJB1 RGS1 CALM3;CALM1 RGS2 ANXA6 GRK6 GJA3 YWHAG GJA5 CALR-1 YWHAZ KCNJ5 GJA8 ITPR1 CACNA1D ITPR3 CACNA1C RGS4 RGS5 RGS3 RGS6 RGS7 GNG13 GNA11 GRK5 GRK4 PRKCD CACNA1S PKIB PKIA GNGT1 PKIG GJB6 RGS18 ARRB1 RGS17 GJC2 ATP2A3 ARRB2 ATP2A2 RGS19 RGS14 RGS16 RGS20 GJA9 STIM2 RGS10 GJC1 ADCY4 CHRM4 GJB4 ADCY2 RGS11 CHRM5 GJB3 ADRB1 GJB5 RGS9 ADRA1D GJD2 ADCY7 CASQ2 ADCY6 ATP1A4 CHRM2 KCNB1 ADCY5 ATP1B3-1 SLC8A3 ATP1B1 SLC8A1 ADCY9 PRKCG PRKCH FXYD2;FXYD6-FXYD2 PRKCB GNB2 PRKCE PRKCA GNB1 ADRB2 GNB4 GNB3 ADCY3 PRKCQ CAMK2B PRKD1 RYR2 GNAI1 CAMK2D CAMK2A PRKCZ GJB2 CAMK2G GNAS-1 GNAQ GNAZ ADRA1B GNG2 GNG5 KCNJ3 GNG4 PRKACA-1 GNG8 CAMK4 CHRM3 ATP1B2 FKBP1A ADRB3 CACNA1E NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260910%WP2882%HOMO SAPIENS Nuclear receptors meta pathway SLC5A6 ALDH3A1 APOA5 SLC5A9 CES3 CES2 EPHA3 SLC5A3 SLC5A5 ANGPTL4 CES5A SLC5A4 RXRA PLTP PRDX6 SLC6A5 SLCO2B1 IP6K3 SLC2A9 PPARGC1A SLC6A7 SLC6A19 SLC6A8 MAFF EP300 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A11 SLC2A10 ABCC5 SLC2A13 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC5A11 SLC5A12 ESR1 SLC5A10 CBR3 TXNRD3 CCND1 MYC NRIP1 PDGFB TNF FKBP5 SPRY1 DNAJC7 IL1B FTL-1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 G6PD BLVRB NR3C1 JUN GSR GSTT2B;GSTT2 GSTM1;GSTM2-1 SLC27A1 GSTA3;GSTA1 ABCG8 GCLC CPT2 ABCG5 ME1 GSTA3;GSTA5;GSTA1;GSTA2 AKAP13 GCLM EPB41L4B GGT1 APOC3 ARL5B SMARCA1 FABP1 PSMC5 RGS2 ENC1 TNS4 SRGN SCD FGFBP1 EDN2 TSC22D3 SERPINB9 NAV3 ADGRF4 CDC42EP3 SCNN1A CYP1B1 PMP2 MFGE8 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 PTGES3-1 SLC26A2 ABHD2 PRRG4 SEC14L1 GPR153 SERTAD2 SULT2A1-4 STOM PPP1R14C CAVIN2 MGST3 PLK2 EPHA2 MGST1 DNAJC15 MGST2 KTN1 S100P CPEB4 DNAJB1 JUNB AGER CYP2B6 NCOA1 HBEGF TXNRD1 GSTM4 STAT3 GSTM3 PRDX1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 KEAP1 SLC7A11 MAFG CYP1A1 SLC7A5 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SRPX2 SLC6A18 IL2 SLC5A8 IFNG SP1 FGF19 IL12A CYP2C9;CYP2C19 POLK UGT1A1;UGT1A6 NCOA3 IGFBP1 SLC5A2 SLC19A2 EGFR SLC6A20 BAAT HES1 ABCB1 ACADM GSTP1 AHRR FGF13 CYP7A1 SLC6A11 HSP90AB1 CYP2A13;CYP2A6;CYP2A7-1 SLC2A2 CBR1-1 ETNK2 VDR HSP90AA1 CYP8B1 GSTA4 SLC5A1-1 TNFAIP3 SLC2A4 THBD PTPA DNER SCP2 AMIGO2 TXN EHHADH-1 LRRC8A PTGR1-1 NCOA6 ACAA1-1 ACOX1 CPT1A PPARD CDKN1B AIP EGR1 JUND SRC CUL1 SMC1A BIRC2 BIRC3 IL11 NCOA2 CCL20 PPARA GADD45B CAP2 NR1H3 CDK4 CDK1 SLC6A9 MYOF BAX ABCC3 SREBF1 ABCC4 ABCC2 IRS2 FOXO1-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 FASN SLC27A5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 KAT2B KLK15 SLC5A7 CCL13;CCL2 BHLHE40 TGFB2 TGFB1 ARNT IL17B NFKB2 TGFBR2 ZIC2 ANKRD1 SRXN1 CES1 SERPINA1 SLC2A12 IL12B ABCB4 SLC10A1 HGF NR1I3 SNAI2 CDKN1C NR1I2 APOA1 NR1H4 ABCB11 TGFA PDE4B GCC1 SOD3 HMOX1 SLC6A6 B3GNT5 NFE2L2 SLC39A2 SLC39A1 SLC39A4 AHR SLC39A3 NRG1 SQSTM1 SLC2A1 POU5F1;POU5F1B SERPINB2 ALAS1 ALOX5AP PTGS2-2 ACKR3-2 NR0B2 GPAM PDK4 PCK1 NQO1 CDC37 TGFBR3 HSPA1A;HSPA1B SLC39A9 FTH1 FGD4 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC6A17 SLC6A16 SLC6A15 SLC6A14 APOA2 SLC6A13 PGD OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260910%WP5093%HOMO SAPIENS Opioid receptor pathways RGS4 OPRL1 ADCY8 CACNA1B DNMT3A ALDH9A1 PGM1 GATA4 TUBB4A;TUBB;TUBB8B;TUBB8 JUP ARC RELA BDNF RGS9 HSPA8 NOS2 NEU2 RPLP2 HMOX1 OPRM1 GNAI2 TLR4 TNF PIK3CG GNA12 MBP ADCY1 E2F1 HDAC1 MAP1LC3B2;MAP1LC3B-1 PRKCG SQSTM1 RAC1 PRKCE LUPUS THERAPIES%WIKIPATHWAYS_20260910%WP5560%HOMO SAPIENS Lupus therapies C3-1 MS4A1 IL6R C1QC CD19 IL12B TNFSF13B LOC110384692;C4A;C4B_2;C4B IL6 CD40 IL25 C1QB CD22 IFNG IL23A C2 CD40LG IL12A CD86 CD80 CD38 IL17D CD28 IL17C IL17F IL17B IL17A IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260910%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease JAK2 IL12RB1 CSF2 IFNG IL23A STAT1 STAT3 TLR4 TNF IL12B TYK2 IL22 RORC STAT5A STAT5B IL17F IL17A STAT4 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260910%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED27 TAF8 MED23 TBP TAF2 TAF13 H4C1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260910%WP4565%HOMO SAPIENS Neural crest cell migration in cancer SORT1 KIDINS220 NGFR CDH11 PIK3R4 PIK3R3 STAT3 PIK3R6 PIK3R5 RHOA FOS MMP2 BDNF TRIO JUN MMP9 EPHB6 EPHB1 EPHB3 NGEF MMP8 BUB1B-PAK6;PAK6 PAK1 PAK5 PAK3 PAK2 PAK4 TIAM1 EPHB2 PIK3CD AKT2 AKT3 PIK3CB AKT1 EPHB4 F2RL2 PIK3CG NTRK2 PIK3CA ARF1 RAC1 GDNF SIGNALING%WIKIPATHWAYS_20260910%WP5143%HOMO SAPIENS GDNF signaling FMOD 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260910%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome DLL1 MCM2 ARF6 INTS4 C1QTNF12 ISG15 PLCH2 TRAF2 CALML6 LRP4 ESR1 DVL1 DLST HSPA8 INTS11 PANK4 INTS13 INTS14 B3GALT6 INTS10 GDE1 CDK11A;CDK11B TMEM52 NOC2L OR4F21;OR4F16;OR4F29;OR4F3 METTL14 SDF4 CCNL2 PLEKHN1 UBE2J2 SAMD11 MUSK VTN ATAD3A;ATAD3B OR4F5;OR4F17;OR4F4 RBX1 SSU72 VEGFA PEX2 ACAP3 HES5 SCNN1D RER1 GABRD CD160 CPTP PEX5 MXRA8 VWA1 TNFRSF14 PEX12 GNB1 AURKAIP1 PARD6B PERM1 TNFRSF18 MEPCE KLHL17 PUSL1 TAS1R3 HES4 TNFSF18 TNFRSF4 CFAP74 BTLA MIB2 RNF223 ELAVL1 PRKCZ PEX10 MORN1 FNDC10 GRIK2 ANKRD65 INTS9 SLC35E2B KRT17 C1orf159 CUL3 DKK3 TNFSF4 TRAF5 SMAD4 MRPL20 SMAD2;SMAD3 MMP23B IFIT1 AGRN PHKG2 COMMD1 IFIH1 NADK SKI TGFB1 TRIM25 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260910%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP2 SGMS1 DEGS2 ASAH1 CERS3 CERS6 CERK CERS1 SPHK2 SPHK1 SGPL1 SGPP2 PLPP1 SPTLC1 GBA SGMS2 GBA2 UGT8 UGCG KDSR CERS4 SGPP1 DEGS1 CERS2 SMPD1 PLPP3 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260910%WP4191%HOMO SAPIENS Caloric restriction and aging SIRT1 MTOR PRKAB2 NAMPT IGF1 PPARGC1A AKT1 TP53 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260910%WP5300%HOMO SAPIENS TROP2 regulatory signaling JAK2 PRKCA RACK1 CDK4 CDK2 NOTCH1 IGF2 STAT1 PRKCD BAX IGF2R CTNNB1 RB1 TACSTD2 CDKN1B MDK IGF1R ACVRL1 ITGA5 CLDN1 JUN FN1 BCL2 CLDN7 SRC CHEK1 ABCC1 CCND1 CDH1 MMP13 PAK4 VIM PTEN CCNE1 TLN1 EGFR CDKN2A PIK3R1 PTK2 PECAM1 PSEN2 ITGB1 IGF1 NFKB1 RAC1 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260910%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX15 ALOX12 FADS2 PTGS2-2 FADS1 ALOX5 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260910%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling MAP3K7 MAPK9 MAPK3 NFKBIB MAPK8 CASP8 MAPK14 IKBKB RIPK1 FADD CTNNB1 CHUK TRAF5 RELA TRAF1 TRAF2 JUN TRAF3 NFKBIA CASP3 RAF1 BIRC2 BIRC3 TNF AKT2 AKT1 TRIM63 TNFRSF12A GSK3B CASP7 HDAC1 RELB NFKB1 MAPK1 NFKB2 RAC1 MAP3K14 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260910%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer APAF1 SERPINE1 DDB2 SESN3 CASP8 BAX PTEN SIAH1 ATM TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 MDM2-2 SHISA5 CYS1 EI24-1 BBC3 PMAIP1 CASP9 BID CHEK2 ZMAT3 CASP3 PERP CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260910%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer MAPK9 MAPK3 RAC3 BAD MAPK10 CTNNB1 CDKN1A FOS BBC3 CASP9 CASP3 TCF7 APPL1 CCND1 MYC DDB2 RALGDS POLK APC2 TP53 AXIN1 CYCS-1 AXIN2 DCC LEF1 RALB PMAIP1 MSH6 BAK1 MSH2 NTN1 TCF7L2 GADD45B MSH3 TCF7L1 GADD45A CSNK1A1 GADD45G APC MAPK8 BAX RHOA RALA-1 EXOC2 KRAS PTGS2-2 SMAD4 JUN TGFBR1-1 BCL2 RAF1 SMAD2;SMAD3 ARAF BIRC5 AKT2 BCL2L11 AKT3 AKT1 REL GSK3B TBK1 TGFB2 BRAF TGFB1 TGFB3 MAP2K2;MAP2K1 MLH1 MAPK1 RAC1 TGFBR2 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260910%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification DLL1 LPAR1 DLL3 MGP DLL4 FGFR3 NOTCH1 ALPL PLAT SAT1 ITGA1 JAG2 SOX6 VEGFA JAG1 GJA5 CALU COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP558%HOMO SAPIENS Complement and coagulation cascades C3-1 C1QC SERPINA1 SERPINE1 PLAT PLAU PROS1 CLU FGB SERPINA5 C8G C3AR1 LOC110384692;C4A;C4B_2;C4B CR2 SERPINF2 PLAUR F2 F3 F7 F5 F8 PLG F9 MASP2 MASP1 CFB CFD C1QB CPB2 C1S C1R SERPINC1 CFI C5AR1 TFPI C2 LMAN1 F2R C6 CLTC C7 C9 CD55 F10 SERPIND1 CR1L;CR1 PROC F13B CFH-3 KNG1 VWF F12 SERPING1 KLKB1 THBD BDKRB1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260910%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling PRKCA RPS6KB2 RAF1 EIF4EBP1 MAPK3 PRKACA-1 TSC2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREB1 MAPK14 AKT1 MTOR SGK1-1 RHEB FSHB RPS6KB1 GRK6 RPS6 FOXO1-1 MAPK1 CGA SRC FSHR APPL1 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260910%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260910%WP5133%HOMO SAPIENS Non classical role of vitamin D AGT ACE2 CYP2R1 ACE CYP27B1 AGTR1 AGTR2 REN THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260910%WP4297%HOMO SAPIENS Thiamine metabolic pathways OGDH BCKDHA PDHA1 TKT SLC19A2 BCKDK TPK1 SLC25A19 SLC19A3 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260910%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer EIF4EBP1 DEPTOR MAPK3 NRAS AR TELO2 HRAS PARP1 IRS1 RPS6KB1 KRAS INPP4B GRB2 PRR5L SOS1 PARP2 RAF1 ARAF RPTOR TSC2 MAPKAP1 MLST8 PDK1 PTEN AKT2 AKT3 AKT1 MTOR TSC1 SOS2 RICTOR BRAF PIK3R1 PIK3CA AKT1S1 MAP2K2;MAP2K1 MAPK1 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260910%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GNA14 GNA15 RYR3 GRIA1 GRIA3 GRIA4 CACNA1A GNA11 HOMER3 GRIA2 PDK1 GRM1 PLCB3 ATP2B2 PLCB4 GNAQ PLCB1 PLCB2 PRKCG TRPC3 CA8 ITPR1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260910%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit CD247 CD80 SPN CD27 IL2 CD3D CD28 CD3G BCL2 CD3E CD86 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260910%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer SYTL4 UNC13D SYTL3 RAB27B SYTL2 TBC1D10A EXPH5 MADD RAB27A RPH3A MLPH RPH3AL SYTL1 GCC2 MYRIP SYTL5 NEPHROGENESIS%WIKIPATHWAYS_20260910%WP5052%HOMO SAPIENS Nephrogenesis FGF20 TCF21 NOTCH2 WNT3A GREB1L SIX2 RSPO3 RSPO1 BMP7 FOXD1 OSR1 WNT4 PAX2 WNT9B FGF8 ALDH1A2 JAG1 MEIS1 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260910%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists PPARA SCARB1 NR1I2 CD36 NPC1L1 CYP2C9;CYP2C19 VDR PPARD INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260910%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 BCLAF1 SETX JARID2 MORC3 ELL EED STK38 TRIM35 EZH2 AEBP2 MTF2 EZH1 RBBP7 RBBP4 THRAP3 SUZ12 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260910%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte BMP4 BMP2 PRDM16 PPARGC1A LEP SLC7A10 CEBPA SMAD1 ADIPOQ CEBPB PPARGC1B SMAD9 ZIC1 SMAD5 HSPB7 BMP7 HOXC9 MPZL2 CEBPG EBF3;EBF1 HOXC8 ZNF423 CIDEA PPARG PLAC8 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260910%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2C18-1 PPARA PPARG EPHX2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260910%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PRKCA GRIA1 MAPK3 ADCY8 GNAI1 GRIA3 PPP1CA ACTC1;ACTG2 GRIA4 CAMK2A GRM5 GRIA2 GRM1 PPP1CB PPP1CC GNAS-1 ACTG1 PRKACB-1 GJB1 RAF1 ARAF GRIN1 PPP1R1A PRKACA-1 DRD1 DRD2 CREB1 DRD4 CAMK4 ACTB-1 RAP1B GRIN2A RAP1A ADCY1 PRKCG MAP2K2;MAP2K1 CALM1 MAPK1 PRKCB WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260910%WP4150%HOMO SAPIENS Wnt signaling in kidney disease MAPK9 WNT11 MAPK8 WNT7B MAPK10 WNT6 WNT1 CTNNB1 WNT2 RHOA WNT4 WNT10B WNT10A NPHP3 FZD2 FZD5 FZD4 FZD7 FZD6 DVL1 FZD9 DVL2 FZD8 DVL3 FZD1 FZD3 WNT3A WNT5A WNT7A WNT2B WNT3 LRP6 WNT9B WNT16 LRP5 WNT5B INVS AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260910%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAB2 RPTOR PRKAB1 PRKAA1 TSC2 MLST8 CSN1S1 MTOR EIF4G1 EIF4A2 RPS6KB1 EIF4E EEF2K PRKAA2 PRKAG1 PRKAG2 CSN2-1 CSN3 PRKAG3 EEF2 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260910%WP2361%HOMO SAPIENS Gastric cancer network 1 S100P H3-3A UBE2C NOTCH1 ACTL6A RNF216 CENPF CCNA1 MCM4 CEP192 TOP2A RUVBL1 INO80D KIF15 ESM1 MYBL2 ECT2 TPX2 H4-16 SMOC2 GATD3B;GATD3A NUP107 LIN9 KIF20B AURKA E2F7 APC VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260910%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins PROC NQO1 F2 F7 VKORC1 VKORC1L1 AIFM2 F9 GGCX UBIAD1 F10 PROS1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260910%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy RASGRF1 MYEF2 PPP3R1 TGFB1 STAT3 AKT2 NFKB1 AKT1 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260910%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias UROS PPOX CPOX HMBS ALAD ALAS2 ALAS1 FECH UROD SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260910%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CSF2 IL12B CCR1 CCR3 CCR2 CXCR4 IL18R1 CCL3L1;CCL3L3;CCL3;CCL18 CCL4L2;CCL4L1;CCL4 IL12RB1 IL12RB2 IL2 CCR7 IFNGR1 IL4 CCR5 CCR4 IFNGR2 IFNG CD40LG IL12A IL5 CD4 CXCR3 TGFB2 IL4R TGFB1 CD28 TGFB3 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260910%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence HPGD ALOX15 GSTP1 ALOX12 LTC4S PTGS1 CYSLTR1 DPEP1 SERPINE1 ALOX5 LTA4H PTGDS CBR1-1 PTGR2 PTGIS EPHX2 PLA2G4A ALOX15B MAPK11 SIRT1 RB1 ALOXE3 CDKN1A GGT5 ABCC4 PRXL2B ALOX5AP GPX1 ALDH1A1 TBXAS1 PTGS2-2 AKR1B1 HPGDS GGT1 FADS2 FADS1 PTGES2 DPEP2 TP53 ELOVL2 PTGES3-1 SLCO2A1 ELOVL5 DECR1 PTGES PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260910%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE6H PDE10A ADCY8 PRKG1 PDE5A PDE6D PDE6B PDE6A ADCY4 ADCY2 ADCY7 ADCY6 PDE3B PDE4B ADCY5 PDE4A PDE4D-1 PPP1R1B CREB1 ADCY10 ADCY9 GRIN2A PDE1B ADCY1 GRIN2C GRIN2B GRIN2D ADCY3 GRIA1 PDE1A CAMK2A GUCY1B1 PDE7A GUCY1A2 GUCY1A1 PDE8B PDE8A PDE2A PDE4C PDE1C PDE3A GRIN1 CHRNA7;CHRFAM7A PDE7B PRKACA-1 NOS1 DRD1 DRD2 ADORA2A PDE12 PDE9A PDE11A PDE6C TNF ALPHA SIGNALING%WIKIPATHWAYS_20260910%WP231%HOMO SAPIENS TNF alpha signaling MAP3K7 PTPRCAP NSMAF MAPK9 NOXO1 MAPK3 NFKBIB MAP2K4 CREBBP PYGL RFK BAD BTRC IKBKB IKBKG CHUK GRB2 CASP9 SKP1 TRAF2 SOS1 BCL2L1 NFKBIA CASP3 PSMD2 CUL1 APAF1 BIRC2 BIRC3 KSR2 MADD PLK1 DIABLO-1 CFLAR TNF CYBA CSNK2A1;CSNK2A3 TANK RFFL CASP7 MAP3K8 BID MAP3K3 TAB3 TAB2 TAB1 MAP3K14 NOX1 GLUL NRAS MAPK8 OTUD7B CASP8 RIPK3 BAX HRAS PRKCZ TRADD TRAP1 HSP90AA1 RIPK1 FADD SMPD2 MAP4K2 TNFRSF1A MAP2K7 FBXW11 KRAS TRAF1 MAP2K6 MAP2K3 JUN MAP3K1 PPP2CB;PPP2CA TNFAIP3 RAF1 NFKBIE TNFRSF1B CDC37 AKT1 MAP3K5 KSR1 REL TBK1 NFKB1 TXN MAPK1 NFKB2 RAC1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260910%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors COL3A1 COL1A2 LAMB2 LAMC1 COL4A2 ITGB6 COL4A1 ITGA1 THBS1 COL6A2 TNXB SDC2 ITGA11 COL6A1 LAMA4 COL5A1 COL6A3 FN1 COL5A3 ITGB5 THBS2 COL5A2 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260910%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PRKCA PRKCQ MAPK3 KISS1R NRAS CYP11A1 PRKCD HRAS PLCB3 PLCB4 ARRB1 ARRB2 AMH PLCB1 PLCB2 KRAS MMP9 RAF1 STAR KISS1 HSD3B1;HSD3B2 BMP15-1 PDK1 PIK3CD AKT2 PIK3CB AKT1 PIK3CG PRKCG PIK3CA PRKCH MAP2K2;MAP2K1 NFKB1 MAPK1 PRKCB GDF9 PRKCE FSHR FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260910%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling CXCL10 MYD88 ITGB2 TRAF6 CBLB IRF3 PLAT LY96 CD14 IL12B IKBKB FGB IKBKG FGA CHUK TICAM1 RHOA LBP FGG IL6 RELA PLG SYK SRC NOS2 TICAM2 TIRAP RASSF5 TYROBP TLR4 TNF TLR3 IFNB1-4 AKT1 FCER1G CCL13;CCL2 IRAK1 IRAK2 REL PIK3CA CXCL2;CXCL3;CXCL1-1 IRAK4 ITGAM NFKB1}