S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a3 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Gcdh Echs1 Acat1 Acat2 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Inpp5d Itpka Inpp5f Synj1 Inpp5a Itpkc Itpkb Ipmk Bpnt2 Impa2 Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 Asmt ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Acsm5 Acsbg2 Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Acat1 Acat2 Fdps Idi1 Hmgcs1 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Adh6 Adh4 Maob Comt Aldh3a2 Tomt Aldh2 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Mthfd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Ip6k2 Plcb2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Itpk1 Cdipt Pik3cg Pik3cb Pik3cd Pip4p2 Pip4p1 Inpp5d Pi4k2b Itpka Plcz1 Pik3c2b Synj1 Plce1 Inpp5a Pik3c2a Itpkc Pik3c2g Itpkb Fig4 Ipmk Mtmr3 Ppip5k1 Pip5k1c Pten Pip5k1b Inpp5k Synj2 Inppl1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Prodh1 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss1 Acss3 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Dhodh Cad Umps GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Sod3 Sod2 Sod1 Cat MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufab1 Ndufc1 Ndufc2 Sdhd Sdhc Sdhb Sdha Ndufa11 Cox6a1 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Mt-co3 Mt-co2 Ndufs8 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa5 Ndufa7 Ndufa6 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cox5b Mt-co1 Cyc1 Mt-nd5 Mt-nd4 Ndufb2 Mt-nd6 Mt-nd1 Uqcrc2 Ndufb3 Mt-nd3 Uqcrc1 Mt-nd2 Mt-nd4l Ndufb8 Ndufb7 Ndufb9 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcr11 Ndufa10l1 Mt-cyb DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dolk Dhrsx Dhdds Nus1 Srd5a3 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Gart Paics Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 Adsl Impdh2 Impdh1 Ak3 Gmps Ak2 Ak4 Adss2 Ak7 Pfas Ak8 Atic Ppat Guk1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk1 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Coq2 Coq3 Ubiad1 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm2 Impdh2 Impdh1 Rrm2b Gmps Nme3 Nme2 Nme1 Nme7 Nme6 Guk1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Dguok Nme3 Dck Nme2 Nme1 Nme7 Nme6 Guk1 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 Ugt2b34l1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Gls2 Gls Asns VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Vkorc1 Nqo1 Ggcx Vkorc1l1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Por Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Ada Pnp GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gsta6 Gsta3 Gsta1 Gsta2 Anpep Gstm7 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Gstp1 Gstt2 Mgst2 Mgst1 Gstt1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart Mthfd1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Alox5 Lta4h Ptgs2 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Chkb Selenoi Pcyt2 Cept1 Etnk2 Etnk1 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Gpx4 Alox12 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal1 Hyal5 Hyal4 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp5mc1 Atp6v1b2 Vps9d1 Atp6v0d1 Atp5mc3 Atp5mc2 Atp5mf Atp5me Atp6v0e1 Atp5mg Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h Atp6v0b Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp6v1c1 Atp5pf Atpaf2 Atp5po Atp6v0c Atp6v1a Mt-atp6 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Shmt2 Shmt1 Mthfd1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Gart Pfas Ppat PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Hmgcs1 Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Lbr PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hmgcs2 Acat1 Hmgcl Bdh2 Bdh1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Akr1a1 Cryl1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Cdipt Plcb4 Plcb3 Pi4k2b Plcz1 Plcb2 Plce1 Plcb1 Pi4k2a Plcg1 Plcg2 Pip5k1c Pip5k1b Pip4k2b Pip4k2c ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Acss1 Aldh3a2 Acss3 Aldh2 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Echs1 Acadsb Acat1 Acat2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads2 Elovl7 Fads1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 St3gal6 St3gal4 St3gal5 St3gal2 B3galt1 B3gnt5 B3gnt2 Fut2 A4galt B4galt1 Fut1 B4galt2 B4galt3 B4galt4 B3galnt1 B4galt6 St6gal1 B4galnt1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis St8sia2 St8sia3 Ugcg St3gal6 St3gal4 B3gnt5 B3gnt2 B4galt1 B4galt2 B4galt3 B4galt4 B4galt6 St6gal1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Aldh7a1 Chdh ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chkb Selenoi Gnpat Pcyt1b Pcyt1a Far2 Far1 Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk2 Etnk1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Kmo Ido2 Acmsd Ido1 Dhtkd1 Kyat1 Tdo2 Aadat Haao Kynu Got2 Aldh8a1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Cyp2a3 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 Hsd17b7 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Acsm5 Fads2 Elovl5 Acsl1 Acsm3 Elovl7 Fads1 Acsm4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt4 Ugcg St8sia1 B4galt6 St6gal1 B4galnt1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt5 B3galt1 Fut2 Abo2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Cyp2e1 Akr1b10 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Ctps1 Dhodh Cad Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Ipmk Itpk1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Ptgis Tbxas1 Cbr1 Hpgds Hpgd Akr1c18 Ptgs1 Ptgs2 Ptges Ptgr2 Ptgds Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Inpp4b Pip4p2 Pip4p1 Inpp5d Inpp5f Synj1 Sacm1l Mtmr3 Pten Mtmr14 Inpp5k Synj2 Inpp4a Inppl1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Gpx4 Alox12 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ephx3 Dpep2 Cyp4f18 Cyp2j4 Cyp4f4 Cyp2d4 Alox15b Lta4h Ptgs2 Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s Ptgis Tbxas1 Hpgds Hpgd Ptgs1 Ptges Ptgr2 Ptgds Ptgr1 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Pten Inpp5k Synj2 Inppl1 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ip6k1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio3 Dio1 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Alox5 Ptgs2 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Oxct1 Acat1 Bdh2 Bdh1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Por Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd Dhtkd1 Aldh8a1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx4 Gpx1 Gpx3 Gpx7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nmnat1 Nmnat2 Nampt HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Cds2 Agpat2 Agpat1 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Fa2h Hacl1 Aldh3a2 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Pc Pgk1 Pgam2 Tpi1l2 Pgk2 Fbp1 Pck1 Fbp2 Bpgm Gpi Mdh1 Mdh2 Eno1 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc3 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc3 Maob Aldh3a2 Aldh2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Tecr Hsd17b12 Elovl1 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Acsm5 Acsbg2 Fads2 Elovl5 Hsd17b12 Acsl1 Acsm3 Elovl7 Acsbg1 Fads1 Acsm4 Slc27a2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Gclm Oplah Gclc Gss Cndp2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ctps1 Ctps2 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Hk3 Pygb Pygl Gck Pgm1 Hk2 Pgm2 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Bckdhb Bckdha Dbt Abat Bcat1 Dld Hibch Bcat2 Echs1 Hibadh Aldh6a1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ntan1 Ate1 Naa20 Ntaq1 Apeh Metap2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Alox5 Ptgs2 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk3 Gck Pgm1 Hk2 Pgm2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 Tsen54 Rtraf Fam98b Tsen2 C9h2orf49 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tyms Dck Tk2 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Tyms Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Pycr1 Aldh18a1 Pycr2 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gstp1 Gsta3 Gsta1 Gsta2 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5e Nt5c3a Impdh2 Impdh1 Ada Pnp Gda Xdh Nt5c1a L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Cbs Cth Ahcy Mat2a Mat1a L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Srm Enoph1 Adi1 Kyat1 Mri1 Mat2a Apip Mat1a D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Inpp5f Synj1 Inpp5a Bpnt2 Impa2 Impa1 Inpp5k Inpp1 Synj2 Inppl1 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Gstm4 Dpep2 Alox5 Lta4h Dpep1 Ltc4s PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp4 Rbp1 Xdh GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclm Gclc Gss DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Maob Comt Aldh3a2 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis St3gal5 Ugt8 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Sat2 Sat1 Aldh1b1 Aldh3b1 Aldh3a1 Maob Aldh3a2 Aldh2 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Bckdhb Bckdha Mccc1 Dbt Auh Bcat1 Ivd Dld Mccc2 Bcat2 Hmgcll1 Hmgcl GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Aspg Asrgl1 Aga Got1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Adh6 Sult1a1 Ugt2b34l1 Aldh3a2 Aldh2 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adsl Ak3 Ak2 Ak4 Adss2 Ak7 Ak8 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat1 Plaat5 Plaat3 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Kmo Ido2 Ido1 Tdo2 Haao Kynu UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcb4 Plcb3 Plaat3 Plaat1 Plaat5 Plcb2 Plcb1 Pla2g2e Pla2g2d Pla2g2a Pla2g4e Pla2g4d Plcg1 Pld4 Plcg2 Pla2g4a Pld6 Pld1 Pld3 Plb1 Pld2 Pla2g12a Pnpla8 Pla2g5 Pla2g3 Pla2g6 Plch2 Pla2g1b Plcd1 Oc90 Plcd4 Pla2g10 Plcd3 Plcz1 Plce1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Gclm Gclc Got1 Gss COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcdc Coasy Pank3 Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Tpi1l2 Aldob Aldoc Tkfc Khk Aldoa PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1l1 Prps1 Prps2 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Cda Tyms Nme3 Dck Nme2 Nme1 Cmpk2 Cmpk1 Tk2 Nme7 Nme6 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chkb Chpt1 Pcyt1b Pcyt1a Chka Cept1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Adh6 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Aanat Tph2 Ddc Tph1 Asmt Tdo2 Haao Kynu Aldh8a1 Kmo Akr1a1 Ido2 Nmnat1 Cyp2a3 Acmsd Ido1 Nmnat2 Gcdh Echs1 Dhtkd1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 Sult1a1 Maob Ugt2b34l1 Aldh2 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acsbg2 Hsd17b10 Acox1 Acox2 Scp2 Hsd17b4 Ehhadh Acaa1b Echs1 Hadh Acsbg1 Slc27a2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Akr1a1 Ddc Maob Aldh3a2 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Tars1 Hars1 Pars2 Dars2 Yars2 Yars1 Dars1 Lars2 Gars1 Qars1 Lars1 Farsa Farsb PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Rrm2 Rrm2b Nme3 Ada Nme2 Nme1 Pnp Nme7 Nme6 Adsl Adk Impdh2 Impdh1 Ak3 Gmps Ak2 Ak4 Adss2 Hprt1 Ak7 Aprt Ak8 Guk1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Gdf1 Kdsr Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Dctd Rrm2 Tyms Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Ctps1 Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 Ctps2 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Aldh7a1 Shmt2 Chdh Dmgdh Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Fh Idh3a Dlst Idh3b Dld Cs Idh3g Suclg1 Suclg2 Ogdh Aco2 Mdh1 Mdh2 Sdhd Sdhc Sdhb Sdha N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Hadhb Acaa2 Acsbg2 Hsd17b10 Eci1 Scp2 Echs1 Hadh Acsbg1 Hadha Slc27a2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Gdf1 Kdsr Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Adh1 Sord LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis St3gal5 B3galt5 B3galt1 B3gnt5 Ugcg Fut2 B4galt6 St6gal1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Kmo Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 Tdo2 Haao Kynu Aldh8a1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Sdr16c5 Rbp4 Rbp1 Aldh1a2 Aldh1a1 Aldh1a3 Rdh16 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide Fut9 Chst1 St8sia2 B4galt1 Fut1 Abo2 B4galt2 B4galt3 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Upp1 Dpys Upp2 Dpyd THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio3 Dio1 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Acsm5 Fads2 Elovl5 Acsl1 Acsm3 Fads1 Acsm4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis Gcnt3 Gcnt2 B3gnt2 B4galt1 B4galt2 B4galt3 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pgk1 Pgam2 Tpi1l2 Pgk2 Pklr Pfkl Pkm Pfkm Pfkp Bpgm Hk3 Gpi Gck Eno1 Hk2 Gapdhs Aldob Aldoc Eno3 Eno2 Aldoa HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B3galt5 Gcnt3 B3gnt2 Fut2 B4galt1 B4galt2 B4galt4 Lalba St6gal1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh2 Impdh1 Pnp Xdh HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galt5 St3gal2 Ugcg Fut2 A4galt Fut1 B3galnt1 B4galt6 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk3 Gck Hk2 Treh LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Cyp2c11 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rdh11 Rdh12 Rdh10 Rpe65 Rbp2 Rbp3 Dhrs9 Lrat Rlbp1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Hsd17b3 Srd5a1 Hsd3b1 Srd5a2 Akr1c18 Cyp17a1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Impdh2 Impdh1 Gmps Nme3 Nme2 Nme1 Nme7 Nme6 Guk1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rdh11 Rdh12 Rdh10 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ephx3 Gpx4 Alox12 Alox5 Cyp2d4 Ptgs2 Alox15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3r2 Pik3r3 Pik3r4 Pi4kb Cdipt Pik3cg Pik3cb Pik3cd Pikfyve Pi4k2b Pik3c3 Pik3c2b Pik3c2a Pik3c2g Sacm1l Fig4 Pi4k2a Pip5k1c Pip5k1b Pik3r5 Pik3r6 Pip4k2b Pik3r1 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gale Hk3 Gnpnat1 Uap1 Gnpda2 Gpi Pgm3 Gck Hk2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Cdo1 Got1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Acot2 Acsbg2 Acot3 Hsd17b12 Elovl6 Acsl1 Elovl7 Acot7 Acsbg1 Slc27a2 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Hoga1 Prodh2 Got2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f4 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Sgpp1 Acsbg2 Acer1 Acer2 Asah2 Acsl1 Asah1 Acsbg1 Sphk2 Sphk1 Ptgr1 Slc27a2 Sgpp2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Ada Pgm2 Pnp PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Tymp Cda Upp1 Upp2 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4k2a Plch2 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 Pip4p2 Pip4p1 Plcz1 Plcb2 Plce1 Plcb1 Mtmr3 Plcg1 Plcg2 Mtmr14 Pip4k2c ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c1 Akr1c2 Srd5a1 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Shmt2 Shmt1 Mthfd2l Aldh1l2 Mthfd1 Mthfd2 Mthfs Mthfr Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Ada Hprt1 Pnp REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Sod3 Sod2 Sod1 Gpx1 Gpx3 Gpx6 Gpx5 Gpx7 Cat Gpx8 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5e Nt5c3a Ada Pnp Xdh Nt5c1a ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Cyp2e1 Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Akr1b10 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Tmlhe Bbox1 Aldh9a1 Shmt1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ippk Ipmk Itpk1 Inpp5k Synj2 Inppl1 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Gpx4 Alox12 Alox5 Alox15b Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Cel Daglb Pnliprp2 Pnpla2 Pnlip Lipc CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Gne Nanp Nans Cmas CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Qprt Nadsyn1 Nmnat2 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) St8sia2 Gcnt3 Gcnt2 B3gnt2 B4galt1 B4galt2 B4galt3 St6gal2 St6gal1 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Acss1 Cyp2e1 Aldh3a2 Acss3 Aldh2 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Acss1 Aldh3a2 Acss3 Aldh2 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Pccb LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1l3 Glb1 Lct NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Cyp4x1 Fmo3 Cyp2a3 Cyp2u1 Fmo2 Cyp2s1 Fmo5 Fmo4 Ugt1a5 Ugt2b34l1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Gale Galt Pgm1 Galm Pgm2 Galk1 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Hk3 Gnpnat1 Uap1 Gpi Pgm3 Gck Hk2 Gfpt1 Gfpt2 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Paics Adsl Atic L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aldh7a1 Dhtkd1 Aadat Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Sephs1 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Hacl1 Phyh Aldh3a2 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Lcmt2 Tyw3 Tyw1 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Plaat1 Plaat5 Napepld Pla2g1b Enpp2 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Echs1 Acadsb Acat1 Acat2 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Kmo Ido2 Nmnat1 Qprt Nadsyn1 Ido1 Nmnat2 Tdo2 Haao Kynu LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsbg2 Acsl3 Acsl1 Acsbg1 Slc27a2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Plcb1 Dagla Ddhd1 Daglb ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Hemk2 Slc20a2 Slc20a1 Trmt112 Aqp9 Slc34a2 Pnp Aqp7 Slc2a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp2b2 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Pgm2 Ugp2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Alox5 Lta4h Ptgs2 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Pmm1 Gpi Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Shmt2 Dmgdh Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Tst Suox HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas2 Hmbs Uros Fech Cpox Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Pccb L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Bckdha Sdsl Dbt Dld Sds GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Hprt1 Pnp CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Asl Ass1 Nos3 Nos2 Nos1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Cbs Cth Bckdhb Bckdha Dbt Suox Dld Mat2a Pccb Mat1a Ahcy Cdo1 Bhmt Bhmt2 Mtr Got1 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Pmvk Hmgcr Mvd Hmgcs2 Acat1 Acat2 Idi1 Hmgcs1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Gpat4 Plpp4 Lpcat3 Mogat1 Gpat2 Gpat3 Plpp2 Lpcat4 Plpp3 Plpp1 Agpat5 Dgat2 Gpam Plppr4 Abhd5 Dgat1 Mboat2 Plppr2 Agpat3 Plppr3 Lclat1 Agpat4 Agpat2 Agpat1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw3 Tyw1 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Csad Fmo1 Cdo1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Mdh1 Mdh2 Got1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Il4 Cabin1 Pou2f1 Ifng Cd40lg Akap5 Faslg Csf2 Junb Nfatc3 Nfatc2 Ptgs2 Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Tfe3 Dcp1a Rbl1 Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Dlx1 Nr3c1 Myod1 Max Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Sap18 Cited1 Sp3 Runx3 Runx1 Runx2 Kat2a Cbfb Vdr Rbbp7 Esr1 Hspa8 Crebbp Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 Tcf3 Cdkn1a E2f5 Smad7 Jun Fos Atf2 Il10 Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Foxo3 Foxo1 Creb1 Col1a2 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il23a Il17a Nfkbia Rela Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il18 Il12b Tnf Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Jak2 Cxcl3 Nos2 Il24 Il17f SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ran Pias1 Pias2 Hdac1 Ranbp2 Xpo1 Hdac4 Ube2i Mdm2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Rela Pik3r1 Mapk8 Mapk1 Ilk Itgav Mapk3 Jun Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Fos Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Rock2 Chuk Map3k14 Nfkb1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Mapk1 Mapk3 Fkbp1a Smad4 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Smad7 Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Src Pxn Irs2 Grb10 Pdlim7 Gdnf Ptpn11 Gfra1 Pik3r1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Dok6 Grb2 Mapk8 Prkca Mapk1 Sos1 Crk Hras Mapk3 Jun Rhoa Bcar1 Rac1 Prkaca Ret Grb7 Shank3 Creb1 Shc1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Mapk1 Col11a1 Mapk3 Col11a2 Fgf19 Cask Ccl5 Bsg Prkaca Hpse Ppib Col2a1 Sdcbp Col3a1 Col1a1 Mmp9 Mmp7 Col4a3 Col5a2 Col6a2 Mmp1 Tgfb1 Col4a1 Hgf Col5a1 Col4a5 Fgf23 Fgfr3 Fgfr4 Lama5 Sdc1 Met Col1a2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Grb2 Prkca Sos1 Hras Rasa2 Rabgef1 Camk2b Nf1 Rasal1 Dab2ip Kras Prkcz Plce1 Lgals1 Lgals3 Rasgrf2 Nras Prkcb AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkc Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Irs1 Irs2 Cebpb Grb2 Il5 Sp1 Col1a1 Socs3 Jak2 Stat5a Pik3r1 Spi1 Stat6 Alox15 Socs5 Ets1 Jak3 Aicda Jak1 Fcer2 Il13ra1 Il13ra2 Arg1 Bcl2l1 Mybl1 Irf4 Oprm1 Tff3 Lta Inpp5d Ptpn6 Thy1 Cbl Ccl17 Il4 Mtor Selp Ccl11 Cd40lg Rps6kb1 Pigr Egr2 Parp14 Mapk14 Il4r Il2rg Stat5b Bcl6 Il10 Fes Hmga1 Retnlg Akt1 Col1a2 Shc1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Rela Ptpn11 Pik3r1 Jak3 Jak1 Grb2 Sos1 Bcl2l1 Il2ra Rac1 Il2 Mtor Rps6kb1 Il2rg Smpd1 Eif3a Hsp90aa1 Sgms1 Rps6 Gab2 Myc Tert Lck Bcl2 Akt1 Prkcz E2f1 Nfkb1 Ugcg Foxo3 Shc1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Frs3 Irs1 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ntf4 Ntf3 Ptpn11 Pdgfrb Ifngr1 Vegfa Gab1 Pdgfb Frs2 Il6r Arhgap35 Nos3 Egf Igf1 Ntrk2 Grb2 Map2k2 Sos1 Ntrk1 Map2k1 Ntrk3 Hras Igf1r Il6 Kras Jak2 Nras Stat1 Pik3r1 Jak3 Jak1 Rhoa Il2ra Prkaca Il2 Ifng Il2rg Gab2 Lck Bdnf Afdn Angpt1 Lmo4 Ngf Shc1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Stat3 Myod1 Ar Ncoa1 Neurog3 Bglap Arnt Ptf1a Runx2 Ghr Camk2d Hif1a Hey2 Maml1 Maml2 Parp1 Crebbp Hes1 Twist1 Ascl1 Rb1 Hes6 Tle1 Gaa Kdm1a Rbbp8 Tcf3 Yy1 Notch1 Gata6 Gata4 Gata1 Cdkn1b Cd4 Ctbp1 Hdac1 E2f1 Jak2 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itgb4 Itga1 Itgb2 Itga2 Itgal Itga10 Itgad Itgb8 Itga7 Itga8 Itgav Itgax Itgb6 Itga3 Itga5 Itgb7 Itga6 Itga9 Itgb1 Itga2b Itgam PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Golga2 Nudc Bora Incenp Kif2a Kif20a Fbxo5 Spc24 Ercc6l Fzr1 Pak1 Ppp1r12a Ect2 Bub1 Tubg1 Cdc14b Cdc20 Ppp2ca Ppp1cb Ccnb1 Rhoa Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Ppp2r1a Wee1 Prc1 Cdk1 Rock2 Btrc Ninl Cdc25c Kiz Tpt1 Aurka Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ube2d3 Xrcc5 Atm Atr Ube2l3 Cdk2 Rbbp8 Ccne1 Cstf1 Bard1 Mre11 Fancl Prkdc Fancc Nbn Tp53 Fancf Fancg Rad51 Rad50 Fancd2 Pcna Ewsr1 Topbp1 Xrcc6 Brca1 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Rhoa S1pr5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Src Stat5a Pik3r1 Camk4 Ywhah Ywhag Gab1 Ywhae Epb41l1 Pdpk1 Camk2a Ywhab Trpc3 Grb2 Trpv1 Sfn Ntrk1 Sos1 Egr1 Bad Hras Ccnd1 Plcg1 Gsk3b Prkcd Ywhaz Kras Akt1 Foxo3 Creb1 Nras Shc1 Ngf IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Il18r1 Stat3 Pias2 Mapk8 Jun Il2ra Mapk9 Il13 Fos Cd3g Cd247 Il2 Prf1 Cd3d Cd28 Crebbp Ifng RT1-Da Cd86 Cd80 Tbx21 RT1-Db1 Tgfb1 Etv5 Irf1 Stat4 Il18 Cd4 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Cul3 Klhl13 Vim Kif23 Incenp Aurkc Kif20a Aurkb Bub1 Rhoa Sgo1 Psma3 Aurka Cenpa Klhl9 Ndc80 Stmn1 Kif2c Ppp2r5d Smc4 Smc2 Ncapg Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 Ncapd2 Septin1 Tacc1 Mylk Des Nsun2 Pebp1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pitpna Ntn1 Dock1 Elmo1 Fyn Yes1 Pik3r1 Nck1 Trio Dcc Map1b Dapk1 Pak1 Ptk2 Unc5b Myo10 Camk2a Unc5a Unc5c Map2k2 Mapk1 Map2k1 Mapk3 Rhoa Plcg1 Bcar1 Rac1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 Gnai1 Mapk1 Gnai3 Gna12 Gnaz Gnao1 Mapk3 Gnai2 Plcg1 Rhoa S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Pde3b Mapk1 Pik3r6 Map2k1 Pik3cg C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Myf6 Tab2 Hipk2 Ada Gata3 Myod1 Cebpb Sp1 Hras Ccnd1 Hspa8 Crebbp Hes1 Cdkn1a Gata1 Cdkn1b Cd4 Kras Nras Spi1 Ets1 Ube2i Adora2b Ccna1 Ccnb1 Slc25a3 Birc3 Prtn3 Map3k7 Ets2 Clta Tfec Pim1 Tom1 Cdkn2a Rag2 Atp2b1 Snd1 Maf Ptcra Kit Smarca2 Mcm4 Cd34 Ptgs2 Lef1 Mat2a Trim28 Nlk Cebpa Pias3 Elane Csf1r Gstm2 Yeats4 Wnt1 H2az1 Myc Ppp3ca Kitlg Cbx4 Bcl2 Casp6 Anpep Mad1l1 Ca1 Zfhx3 Cdk6 Col1a2 Lect2 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Rras Src Pxn Ephb1 Ephb2 Ephb3 Tf Efnb1 Efnb2 Pik3r1 Nck1 Efnb3 Rap1a Rap1b Synj1 Dnm1 Pak1 Ptk2 Itsn1 Rock1 Kalrn Efna5 Grb2 Mapk1 Map2k1 Crk Hras Mapk3 Rac1 Kras Grb7 Nras Shc1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Src Pik3r1 Pdpk1 Ikbkb Mapk8 Birc2 Ikbkg Map2k7 Map2k6 Cltc Cflar Birc3 Faim2 Bid Pik3cb Mapk9 Casp8 Rfc1 Casp3 Syk Ripk1 Btk Fas Fadd Map3k1 Ezr Mapk10 Mapk11 Faslg Chuk Mapk14 Smpd1 Akt1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Rela Raf1 Egf Igf1 Mapk8 Map2k2 Mapk1 Map2k1 Bad Mapk3 Birc3 Bid Prkcd Casp8 Ripk1 Fadd Map3k1 Rb1 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Smpd1 Tnfrsf1a Bag4 Cradd Tnf Pdgfa Traf2 Prkra Myc Cycs Map2k4 Sphk2 Bcl2 Akt1 Prkcz Bax Nfkb1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Th Tor1a Src Grk5 Sncaip Slc6a3 Ube2l3 Lyn Prkn Uchl1 Fyn Maob Yes1 Fgr Hck Park7 Snca Bad Fkbp1a Prkcd Syk Ptk2b Ppp2r5d Lck Blk Csnk2a1 Pld1 Plcb2 Klk6 Pld2 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Ikbkb Src Nfkbia Rela Btrc Lck Mapk14 Pik3r1 Nfkb1 Arrb2 Rel Syk RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Srf Ppp1r12a Ccn1 Rock1 Slc9a1 Acta1 Mapk12 Mapk8 Slc9a3 Diaph1 Rdx Map2k6 Cfl1 Jun Msn Rhoa Pten Cit Map2k3 Myl2 Limk1 Fos Limk2 Pkn2 Pkn1 Sh3gl2 Tln1 Pip5k1c Ezr Pip5k1b F2rl2 Rock2 Vcl Scai Atf2 Cdkn1b Map2k4 Prkcz Pld1 Itgb1 Pld2 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Irs1 Egfr Src Pdgfrb Pdgfb Dok1 Egf Grb2 Crk Socs3 Blk Jak2 Itga2b Stat5a Lyn Stat3 Fyn Fgr Pik3r1 Yes1 Hck Rhoa Bcar1 Ins2 Prl Ybx1 Prlr Cdh2 Stat5b Csn2 Csf1 Insr Trpv6 Cav1 Txn Ptpn1 Csf1r Csk Fcgr2a Capn1 Spry2 Fer Lck Lep Nox4 Akt1 Lat Lepr Shc1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Epb41 Lama1 Src Lama3 Itga2 Ephb2 Sdc2 Mapk8 Mapk1 Hras Mapk3 Rhoa Fgf19 Cask Prkcd Prkaca Casp3 Sdcbp Mmp2 Ezr Csf2 Tgfb1 Fgf23 Fgfr3 Fgfr4 Nf1 Bax Fn1 Kng2l1 Cav2 Itgb1 Trappc4 Rack1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Ptpn7 Raf1 Braf Map3k8 Elk1 Prkca Mapk1 Map2k1 Hras Mapk3 Kras Fos Nras Prkcb ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Hrk Ccna2 Serpinb5 Atf3 Kat5 Macroh2a1 Col24a1 Jdp2 Ruvbl2 Jund Csrp2 Gadd45a Sele Prkca Dusp5 Tgfb2 Dusp1 Pdgfra Dusp10 Ccnd1 Dusp8 Hbg1 Ppargc1a Mapk9 Cbfb Esr1 Hes1 Mapk11 Rb1 Cdk4 Socs3 Il6 Nf1 Nos2 Th Il23a Cul3 Mapk8 Mapk1 Arg1 Bcl2l1 Mapk3 Jun Fos Mmp2 Pou2f1 Ifng Plau Ins2 Mapk14 Junb Atf2 Bcl2 Creb1 Brca1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Src Lyn Fyn Yes1 Fgr Hck Rock1 Efna5 Pik3r6 Pik3cg Crk Rhoa Plcg1 Efna1 Efna2 Efna3 Vav3 Arhgef15 Cbl Crkl Ngef Epha1 Epha2 Vav2 Epha3 Epha4 Epha6 Epha7 Cdk5 Epha8 Lck Blk SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Sirt5 Sirt4 Nfkbia Rela Stat3 Ranbp2 Xpo1 Max Hdac4 Ube2i Ran Sap18 Prkaca Rbbp7 Crebbp Btrc Nr2c1 Hdac3 Hdac11 Yy1 Hdac10 Hdac7 Smad7 Mta2 Tnfrsf1a Hdac8 Gata1 Mbd3 Hdac2 Mbd2 Tnf Pparg Chd3 Chd4 Sirt3 Hdac1 Sirt2 Sirt1 Smurf1 Nfkb1 Gatad2a Mxd1 Wdr77 Sirt6 Gatad2b Gata2 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Itga1 Ctnnb1 Klc1 Itga2 Tshr Cdh1 Slc2a4 Adrb2 Scamp2 Rala Acap1 Exoc3 Agtr1 Ctnna1 Exoc5 Exoc6 Vamp3 Nme1 Exoc2 Dnm2 Avpr2 Spag9 Itgav Exoc7 Cltc Bin1 Ctnnd1 Mapk8ip3 Arf6 Pip5k1c Ins2 Itga10 Itga7 Itga8 Itga3 Itga5 Itga6 Pld1 Itga9 Itgb1 Pld2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ctnnb1 Rala Ywhah Ywhag Xpo1 Ywhae Ran Gadd45a Ywhab Ikbkb Mapk8 Sfn Ccnb1 Plk1 Csnk1a1 Ywhaz Mapk9 Csnk1g3 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Crebbp Ralb Mst1 Mapk10 Sod2 Usp7 Faslg Chuk G6pc1 Rbl2 Cdk2 Cat Csnk1d Sgk1 Bcl6 Csnk1e Cdkn1b Sirt1 Akt1 Foxo4 Foxo3 Foxo1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 Sgpl1 Gna15 Gna14 Abcc1 Gna13 Gnaq Sphk1 S1pr1 S1pr3 S1pr2 Sgpp1 Sphk2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Src Raf1 Slc2a4 Ywhah Ywhag Ywhae Pdpk1 Ywhab Sfn Bad Bcl2l1 Gsk3b Ywhaz Prkaca Mtor Chuk Cdkn1a Cdkn1b Hsp90aa1 Prkdc Rictor Akt3 Akt1 Akt2 Foxo4 Casp9 Foxo3 Kpna1 Foxo1 Mapkap1 Gsk3a Mlst8 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Tiam1 Enah Src Ctnnb1 Nckap1 Klhl20 Ap1m1 Cdh1 Wasf2 Jup Cttn Tjp1 Dlg1 Pik3r1 Abi1 Rap1a Rap1b Ctnna1 Nme1 Crk Ccnd1 Rhoa Ctnnd1 Arf6 Rac1 Pip5k1c Vav2 Akt1 Itgb7 Afdn SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Pik3r1 Stil Dhh Arrb2 Hhip Ihh Lrp2 Gli2 Shh Grk2 Lrpap1 Tgfb2 Smo Ptch1 Boc Pthlh Cdon Akt1 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk1 Plk3 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Nckap1 Wasf2 Abi1 Crk Map2k7 Map2k6 Ncf1 Ncf2 Mapk9 Brk1 Arhgdia Noxa1 Baiap2 Iqgap3 Arpc1b Actr2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Noxo1 Arpc2 Cyba Abi2 Cybb Arpc5 Arpc4 Map3k11 Map2k4 Racgap1 Plcb2 Ctnnb1 Stat5a Cdh1 Stat3 Ctnna1 Pak1 Mapk8 Cfl1 Jun Bcar1 Map2k3 Rac1 Limk1 Pip5k1c Map3k1 Pip5k1b Mapk14 Atf2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Guca1a Rgs9 Lrat Gucy2f Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Cnga3 Arr3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Gnb3 Guca1b Gnb5 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef7 Mcf2l Arhgef6 Spata13 Arhgef9 Fgd1 Git1 Dnmbp Mcf2 Arhgap17 Dock11 Itsn1 Ralbp1 Bcar3 Nme1 Arhgef25 Farp2 Dock6 Arhgap1 Apc Itsn2 Plcg1 Arhgdia Vav3 Ngef Vav2 Racgap1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Elk1 Serpine1 Vegfa Ets1 Sp1 Adora2a Epo Eif3e Arnt Bhlhe40 Efna1 Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Crebbp Pou5f1 Twist1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Sirt1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Src Kat5 Nr3c1 Rel Mdm2 Ar Ncoa2 Ncoa1 Mapk8 Egr1 Map2k6 Jun Gsk3b Pkn1 Pou2f1 Crebbp Mapk14 Smarca2 Nr2c2 Nr2c1 Hoxb13 Carm1 Dnaja1 Zmiz2 Hdac7 Trim24 Cebpa Appbp2 Pde9a Hsp90aa1 Kat7 Nr0b1 Spdef Rxrb Rxra Hdac1 Map2k4 Smarce1 Ehmt2 Sirt1 Smarcc1 Rxrg Senp1 Tmprss2 Foxo1 Rchy1 Rack1 Gata2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Elk1 Pik3r1 Srf Cav1 Jak1 Grb2 Sos1 Crk Itgav Pdgfra Jun Plcg1 Csnk2a1 Fos Cav3 Shc1 Crkl Shf SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncstn Aph1b Egfr Src Ncan Sdc3 Ptn Mc4r Psenen Cttn Pomc Psen1 Fyn Agrp Fgf23 Fgfr3 Fgfr4 Fgf19 Cask SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Atf1 Gdi1 Eif4ebp1 Pla2g4a Mitf Cebpb Rab5a Elk4 Slc9a1 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Eif4e Jun Mapkapk5 Rps6ka5 Hbp1 Ppargc1a Mknk1 Atf6 Esr1 Mef2c Mapk11 Mapk14 Ptgs2 Atf2 Tp53 Nos2 Creb1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Src Pxn Dock1 Git1 Abi1 Ptk2 Crk Bcar1 Spp1 Arf6 Rac1 Ywhaz Prkar1b Prkaca Mdk Jaml Jam2 Cd81 Ptpra Ptk2b Tln1 Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs2 Fn1 Itgb1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Dkk1 Ror2 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Wnt3 Wnt1 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Atf3 Nr3c1 Jund Il5 Sp1 Dusp1 Egr1 Ccnd1 Cbfb Hif1a Esr1 Mmp1 Cdkn1b Il6 Ccl12 Gata2 Th Dmp1 Ctnnb1 Gja1 Edn1 Elf1 Penk Dmtf1 Mt2 Nts Mafg Bag1 Tcf7l2 Cops5 Ets1 Fabp4 Ccn1 Timp1 Agt Acta1 Nppa Fosl1 Jun Pten Fos Bcl2l11 Il2 Il4 Cdkn2a Mmp9 Ifng Plau Cdk1 Maf Csf2 Tgfb1 Junb Nfatc3 Nfatc2 Atf2 Il10 Tp53 Myc Creb1 Col1a2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Sdcbp Stat5a Lyn Ptpn11 Pik3r1 Stat5b Csf2rb Grb2 Il5 Il5ra Cish Jak2 Pim1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Ctnnb1 Pxn Arhgef7 Arhgef6 Xpo1 Ruvbl2 Ppp1r12a Diaph1 Ilkap Ilk Ruvbl1 Rhog Jun Ccnd1 Ppp1r14a Ppp1r14c Gsk3b Ppp1r14b Naca Rac1 Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Parp1 Snai1 Lims2 Zeb1 Actn1 Parvb Zyx Cdc37 Parva Ckap5 Aurka Myl9 Hsp90aa1 Rictor Akt1 Creb1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Ctnnb1 Gja1 Jup Cttn Ptpn11 Pik3r1 Ctnna1 Rock1 Mapk8 Rhoa Plcg1 Ctnnd1 Rac1 Myl2 Gsn Pip5k1c Lrp5 Cdh2 Daglb Camk2g Mapre1 Dctn1 Gap43 Ptpn1 Kif5b Cnr1 Fgfr1 Gria2 Dagla Fer Axin1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Abca1 Fam120b Rara Srebf1 Rps6kb1 Nr4a1 Tgfb1 Ncoa1 Pparg Tnf Rxrb Rxra Med1 Rarg Bcl2 Thrb Thra Rxrg Nr1h4 Nr1h3 Nr1h2 Vdr Ppard Ppara P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Col18a1 Mpg Nrip1 Sra1 Apbb1 Ebag9 Phb2 Pdia2 Anp32a Ap1b1 Cebpb Pou4f1 Lcor Ncoa2 Pou4f2 Ncoa1 Nr0b2 Cd82 Dscam Pgr Axin2 Ccnd1 Tff1 Setsip Ncoa7 Atp5pf C3 Mta1 Hsf2 Xbp1 Esr1 Sod1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Smad4 Uba3 Nedd8 Ctsd Stat5a Hdac4 Jun Chuk Prl Nr0b1 Myc Hdac1 Med1 Pcna Lmo4 Brca1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Rasa1 Pxn Rela Stat5a Elf1 Elk1 Ptpn11 Fyn Pik3r1 Nck1 Agtr1 Ets1 Pak1 Ptk2 Nos3 Grb2 Mapk8 Mapk1 Crk Mapk3 Rac1 Mmp2 Rps6kb1 Tnip2 Mapk14 Grb14 Plg Fgf2 Stat5b Angpt2 Cdkn1a Angpt4 Fes F2 Bmx Elf2 Tnf Itga5 Akt1 Nfkb1 Fn1 Grb7 Angpt1 Foxo1 Itgb1 Shc1 Pld2 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Prkce Ptpn7 Raf1 Braf Elk1 Mapk8 Map2k2 Prkca Mapk1 Egr1 Map2k1 Fosl1 Hras Mapk3 Jun Il2ra Mapk9 Fos Cd3g Cd247 Il2 Prf1 Cd3d Ifng Faslg Junb Nfatc3 Nfatc2 Il2rg Stat4 Tnfrsf4 Ifnar1 Tnf Eomes Egr4 Prkcq Tnfrsf9 Cd8b Kras Cd8a Ifna1l1 B2m Nras Prkcb SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Rasa1 Src Raf1 Pxn Braf Nck1 Rap1a Rap1b Arhgap35 Ptk2 Grb2 Sos1 Crk Map2k1 Ccnd1 Plcg1 Mapk9 Bmx Map2k4 Itga5 Arhgef11 Asap1 Itgb1 Arhgef28 Arhgap26 Capn2 Rras Ptpn21 Arhgef7 Dock1 Elmo1 Fyn Pik3r1 Yes1 Ets1 Pak1 Acta1 Mapk8 Mapk1 Itgav Jun Rhoa Bcar1 Mapk8ip3 Rac1 Nck2 Git2 Tln1 Actn1 Vcl Rock2 Grb7 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Itgb4 Lama1 Lamb2 Lamb3 Lama3 Lamb1 Lamc1 Itga6 Lama5 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Atm Atr H2ax Ube2t Blm Chek1 Wdr48 Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc4 Rfc2 Rmi1 Hus1 Rpa2 Rad17 Atrip Brip1 Brca2 Rad1 Faap24 Fan1 Fbxw11 Hes1 Btrc Mre11 Fancl Fancc Nbn Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Atm Ada Tp63 Mdm2 Sfn Brca2 Gsk3b Hbp1 Runx1 Dlx5 Dlx6 Bdkrb2 Ppp2r5a Vdr Igfbp3 Hells Sec14l2 Cdkn2a Itch Stxbp4 Hes1 Tcf7l1 Ccnb2 Rrad Krt14 Wwp1 Rab38 Col5a1 Nrg1 Tbxt Adrm1 Il1a Notch1 Axl Perp Mre11 Itga3 Rack1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Sptan1 Apaf1 Diablo Vim Top1 Srebf1 Dffa Dffb Ptk2 Acta1 Birc2 Birc3 Bid Casp8 Limk1 Gsn Casp3 Ripk1 Prf1 Parp1 Map3k1 Madd App Tnfrsf1a Arhgdib Tfap2a Cradd Tnf Slk Numa1 Traf2 Lmnb1 Lmnb2 Cycs Pidd1 Casp7 Bcl2 Krt18 Casp6 Bax Casp4 Casp9 Cfl2 Xiap Satb1 Casp2 Casp1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Tiam1 Arhgef7 Arhgef6 Arhgef2 Dock1 Spata13 Dock2 Elmo1 Abr Eps8 Rap1gds1 Trio Abi1 Prex1 Prex2 Mcf2 Arhgap17 Vav1 Bcr Ralbp1 Arhgap9 Kalrn Arhgef25 Dock6 Arhgap1 Sos1 Rac1 Arhgdia Vav3 Ngef Vav2 Racgap1 Rasgrf2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Itgb2 Hck Rap1a Rap1b Rock1 Lrp1 Selplg Ccn2 Jam3 Plat Ager Icam1 Mst1r Rhoa Apob Thy1 Jam2 Mmp2 Tln1 Selp Mmp9 Mst1 Myh2 Plau Plg Tnf Il6 Nfkb1 Itgam ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Tiam1 Kalrn Nme1 Mapk1 Mapk3 Rhoa Arf1 Rab11fip3 Arf6 Rac1 Rab11a Pld1 Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Rasa1 Raf1 Pxn Ptpn11 Pla2g4a Vav1 Ptk2 Dok1 Ikbkb Grb2 Map2k2 Ikbkg Sos1 Map2k7 Dusp1 Map2k1 Hras Plcg1 Itk Fcer1a Plpp1 Klrg1 Hcls1 Btk Cblb Wipf1 Lat2 Lcp2 Pak2 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Map2k4 Nfkb1 Prkcb Pld2 Rela Lyn Fyn Pik3r1 Mapk8 Mapk1 Mapk3 Jun Inpp5d Fos Syk Cbl Map3k1 Chuk Nfatc2 Sphk1 S1pr1 Gab2 Fer Akt1 Lat Shc1 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Src Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Pdgfrb Cxcr4 Vegfa Pdgfb Gna11 Gna15 Gna14 Gna13 Gnaq Mapk1 S1pr3 Mapk3 Rhoa Akt3 Akt1 Rac1 Jak2 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Rhoa Madcam1 Itgb7 Itgb1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Tiam1 Frs3 Rasa1 Ntf4 Ntf3 Ptpn11 Rap1a Rap1b Gab1 Frs2 Dnm1 Ntrk2 Grb2 Sos1 Ntrk1 Crk Map2k1 Ntrk3 Hras Ccnd1 Plcg1 Crkl Matk Sqstm1 Faim Prkci Maged1 Dnaja3 Ngfr Shc3 Shc2 Gipc1 Rgs19 Dynlt1 Nedd4l Abl1 Kras Prkcz Arhgap32 Rit1 Rit2 Ehd4 Nras Mcf2l Dock1 Elmo1 Stat3 Pik3r1 Mapk1 Rhog Mapk3 Rhoa Rac1 Gab2 Bdnf Ngf Shc1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Cyth1 Dapp1 Src Inppl1 Plekha1 Plcg2 Lyn Blnk Adap1 Arf5 Fyn Yes1 Fgr Pik3r1 Hck Rap1a Pdpk1 Pik3r6 Pik3cg Hras Rhoa Plcg1 Pten Arf1 Arf6 Rac1 Pik3cb Inpp5d Itk Syk Btk Sgk1 Hsp90aa1 Lck Kras Lat Blk Foxo3 Cyth2 Zap70 Nras Cyth3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Tab2 Stat5a Wwox Fyn Erbb2 Pik3r1 Erbb4 Nedd4 Lrig1 Adam17 Ereg Hbegf Mdm2 Nrg2 Btc Cbfa2t3 Grb2 Nrg4 Mapk1 Nrg3 Dlg4 Grin2b Mapk3 Pik3cb Itch Prl Wwp1 Prlr Nrg1 Stat5b Jak2 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Raf1 Stat5a Lyn Stat3 Ptpn11 Stat1 Pik3r1 Ikbkb Csf2rb Grb2 Map2k2 Mapk1 Cish Sos1 Map2k1 Hras Mapk3 Osm Irf8 Ywhaz Inpp5d Prkaca Fos Pim1 Syk Prkacb Csf2 Stat5b Gab2 Ccl12 Kras Jak2 Nras Shc1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk12 Map2k6 Ccnd1 Mapk13 Map2k3 Eef2k Snta1 Stmn1 Pkn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Enah Egfr Ctnnb1 Nckap1 Cdh1 Git1 Nck1 Abi1 Exoc3 Ctnna1 Rock1 Egf Igf1 Diaph1 Igf1r Rhoa Ctnnd1 Arf6 Efna1 Myl2 Lima1 Vasp Aqp5 Kifc3 Mgat3 Aqp3 Lpp Epha2 Pip5k1c Nectin2 Myo6 Stx4 Actn1 Vcl Zyx Hgf Met Afdn SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Src Raf1 Pxn Braf Grb10 Ptpn11 Nck1 Vegfa Gab1 Ptk2 Pdpk1 Nos3 Rock1 Grb2 Prkca Map2k2 Mapkapk2 Map2k1 Map2k6 Plcg1 Arf1 Prkcd Pak2 Mapk11 Prkcb Ctnnb1 Fyn Pik3r1 Nedd4 Ctnna1 Dnm2 Mapk1 Itgav Mapk3 Rhoa Map2k3 Fbxw11 Prkaca Nck2 Ptpn6 Cbl Ptk2b Vcl Myof Cdh5 Camkk2 Mapk14 Akap1 Sh2d2a Hsp90ab1 Hgs Ptpn2 Fes Vtn Cav1 Hsp90aa1 Akt1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Eif4g1 Gpam Rpl11 Id2 Eif2s1 Supt7l Pfkm Lin28b Myct1 Ccnd2 Kat5 Tfrc Pdcd10 Hspa4 Max Ireb2 Ruvbl2 Eif4a1 Ubtf E2f3 Eif4e Kat2a Mta1 Crebbp Smad3 Smad4 Cdk4 Npm1 Bax Nme1 Ruvbl1 Fosl1 Ccnb1 Pim1 Slc2a1 Mmp9 Snai1 Hmga1 Riox2 Eno1 Bmi1 Ndufaf2 Hsp90aa1 Bcat1 Ddx18 Nbn Shmt1 Tp53 Myc Hspd1 Tert Prdx3 Cad Nme2 Mtdh Actl6a Cdc25a Serpini1 Odc1 Taf9 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Src Lyn Fyn Rala Yes1 Fgr Hck Pak1 Dusp16 Traf6 Pak3 Map3k3 Dusp1 Map3k12 Map2k6 Dusp10 Dusp8 Map2k3 Rac1 Ripk1 Ralb Pak2 Mapk11 Mapk14 Map2k4 Lck Blk SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Raf1 Stat5a Grb10 Lyn Stat3 Ptpn11 Stat1 Pik3r1 Gab1 Vav1 Mitf Pdpk1 Dok1 Grb2 Mapk8 Map2k2 Sos1 Map2k1 Stap1 Bad Hras Mapk3 Epor Epo Ptpro Pten Grap2 Gsk3b Pik3c2b Sh2b2 Map4k1 Ptpn6 Tec Spred1 Cbl Crkl Spred2 Crebbp Rps6kb1 Kit Matk Fer Kitlg Bcl2 Akt1 Jak2 Foxo3 Shc1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Bmp4 Shh Fgf7 Gpc3 Mapk8 Furin Ptch1 Mapk9 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Src Pxn Adam2 Adam12 Vcam1 F13a1 Adam15 Csf2 Adam8 Sat1 Kcnj15 Vegfa Vegfd Vegfc Tgm2 Bcar1 Spp1 Fn1 Rac1 Itga9 Nos2 Itgb1 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Xrcc5 Pnkp Polm Nhej1 Dntt Dclre1c Prkdc Aptx Lig4 Aplf Xrcc4 Poll Xrcc6 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Src Raf1 Pxn Ptpn11 Nck1 Rap1a Rap1b Gab1 Eif4ebp1 Ptk2 Pdpk1 Rab5a Grb2 Map2k2 Sos1 Crk Egr1 Map2k1 Eif4e Bad Hras Plcg1 Crkl Pak2 Hgf Prkci Met Map2k4 Rptor Kpnb1 Prkcz Numb Sh3kbp1 Eps15 Rin2 Arhgef4 Pak4 Akt1s1 Muc20 Ctnnb1 Inppl1 Ranbp10 Cdh1 Pik3r1 Ctnna1 Ets1 Pak1 Mapk8 Mapk1 Apc Mapk3 Jun Rhoa Bcar1 Arf6 Rac1 Inpp5d Nck2 Cbl Sh3gl2 Mtor Snai1 Map3k1 F2rl2 Hgs Ptpn2 Ptpn1 Gab2 Akt1 Akt2 Mlst8 Shc1 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Egfr Src Gnai1 Gnai3 Stat3 Ptpn11 Stat1 Pik3r1 Nck1 Gab1 Pak1 Ptk2 Egf Grb2 Mapk1 Sos1 Hras Mapk3 Plcg1 Pik3cb Ptpn6 Nck2 Gsn Tln1 Pip5k1c Ptpn1 Kras Nras Shc1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Gnai1 Plcb3 F2r Gnai3 Gna12 Arhgef1 Plcb1 Gnaz Gnao1 Trpc6 Grk3 Gnai2 Snx2 Pik3r1 Snx1 Arrb1 Prkcg Dnm1 Gnb1 Nos3 Rock1 Gna13 Dnm2 Prkca Rhoa Prkcd Myl2 Vasp Arhgdia Pkn1 F2rl2 Rock2 Zyx Gna11 F2 Gna15 Gna14 Gnaq Plcb2 Prkcb SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Lama1 Lama3 Cxcl12 Ptk2 Sdc4 Fgf6 Nudt16l1 Tfpi Dnm2 Prkca Rhoa Prkcd Ccl5 Rac1 Mdk Sdcbp Mmp9 Adam12 Actn1 Cxcr4 Plg Fgf2 F2 Fgfr1 Gipc1 Itga5 Fn1 Itgb1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Rpl11 Atm Hipk2 Atr Ccna2 Kat5 Gsk3b Prkcd Mapk9 Crebbp Nedd8 Cdk2 Yy1 Abl1 Chek1 Mdm2 Mapk8 Smyd2 Cse1l Kat8 Ppp2ca Fbxo11 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Csnk1a1 Csnk1g3 Rassf1 Csnk1g1 Ccng1 Chek2 Csnk1g2 Setd7 Rpl5l1 Cdkn2a Skp2 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Usp7 Daxx Mapk14 Csnk1d Csnk1e Trim28 Tp53 Akt1 Rchy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Gata3 Il5 Egr1 Fosl1 Jun Irf4 Il2ra Fos Batf3 Casp3 Il2 Il4 Cblb Pou2f1 Itch Ifng Cd40lg Maf Egr2 Tbx21 Faslg Rnf128 Csf2 Ctla4 Cdk4 Junb Dgka Nfatc3 Slc3a2 Nfatc2 Egr3 Ptgs2 Foxp3 Ptpn1 Tnf Pparg Egr4 Prkcq E2f1 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Irs1 Gnai1 Gnai3 Gna12 Gnaz Elk1 Gnao1 Cdh5 Mapk14 Gnai2 Gna11 Pak1 Gna15 Gna14 Gna13 Gnaq Mapk8 Mapk1 S1pr2 Jun Mapk3 Rhoa Rac1 Fos NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gnai1 Plcb3 Raf1 Plcg2 Gnai3 Plcb1 Gnaz Gnao1 Gnai2 Pik3r1 Gnb1 Ptk2 Ar Map2k2 Mapk1 Map2k1 Hras Mapk3 Plcg1 Rac1 Fos Gnrh1 Shbg Pelp1 Akt1 Plcb2 Creb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Tp53 Cdc25c Plk3 Ccne1 Chek2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Itgb4 Lama3 Gja1 Dmtf1 Ccna2 Jund Nos3 Sp1 Fosl1 Jun Ccnd1 Bglap Mmp2 Cdkn2a Mmp9 Plau Mmp1 Junb Nfatc3 Nfatc2 Hmox1 Txlng Usf2 Lif Il6 Dcn Thbd Ccl12 Mgp Atf4 Col1a2 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Atm H2ax Blm Kat5 Mdm2 Ywhab Rad17 Bid Chek2 Cdc25c Rbbp8 Trim28 Mre11 Dclre1c Nbn Ctbp1 Xrcc4 Terf2 Abl1 Tp53bp1 Rad50 ABRAXAS1 Fancd2 Ube2n Uimc1 Cdc25a Smc1a Brca1 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Apaf1 Nfkbia Rela Mapk8 Map2k7 Cflar Birc3 Bid Casp8 Casp3 Cd247 Ripk1 Fas Fadd Faslg Chuk Daxx Map3k14 Tnfrsf1a Bag4 Cradd Tnf Traf2 Cycs Casp7 Bcl2 Casp6 Nfkb1 Casp9 Casp2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Bgn Sftpa1 Myd88 Vcan Irak4 Tlr6 Chuk S100a9 Cd14 Tirap Tlr4 Tlr3 S100a8 Tlr2 Ikbkb Ikbkg Hspd1 Rhoa Irak2 Irak1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il17a Ifng Stat5a Il6st Gata3 Tbx21 Il1b Stat3 Tgfb1 Stat1 Il12rb2 Ebi3 Il27 Il12a Stat4 Stat2 Il18 Jak1 Il12b Tnf Il6 Jak2 Il2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Ncstn Apaf1 Aph1b Myd88 Diablo Psenen Ntf4 Psen1 Ntf3 Ywhae Zfp110 Ikbkb Traf6 Rhob Birc2 Lingo1 Ikbkg Omg Ntrk1 Mag Mageh1 Bad Smpd2 Bex3 Bex1 Nsmce3 Rtn4 Mapk9 Ripk2 Arhgdia Ndn Casp3 Prdm4 Sort1 Prkacb Mmp7 Furin Mapk10 Plg Sqstm1 Prkci Maged1 Ngfr Cycs Prkcz Pik3r1 Adam17 Mapk8 Rhoa Birc3 Rac1 Bcl2l11 Chuk App Tp53 Akt1 Casp6 E2f1 Bdnf Casp9 Xiap Ngf Shc1 Irak1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Nkd2 Cul3 Ranbp3 Ctnnb1 Dvl1 Klhl12 Pip5k1b Dvl3 Pi4k2a Lrp6 Cav1 Wnt3a Apc Axin1 Fzd5 Gsk3b Csnk1g1 Ppp2r5a Gsk3a FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Src Cdh1 Sdc2 Cttn Ptpn11 Stat1 Pik3r1 Gab1 Frs2 Pdpk1 Camk2a Grb2 Mapk1 Sos1 Mapk3 Jun Plcg1 Ctnnd1 Bglap Fgf19 Spp1 Runx2 Fos Cbl Ptk2b Mmp9 Plau Il17rd Ncam1 Ssh1 Fgfr2 Rps6ka1 Cdh2 Stat5b Fgf23 Fgfr3 Fgfr4 Fgfr1 Spry2 Akt1 Shc1 Pak4 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Smad4 Smad5 Fkbp1a Amhr2 Amh Bmp7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Xrcc5 Nrip1 Ar Ncoa2 Ccnd1 Casp8 Uba3 Kdm1a Pawr Hip1 Lats2 Fhl2 Kdm4c Zfp318 Prdx1 Fkbp4 Rps6ka3 Mak Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Snurf Ncoa4 Ncoa6 Ccnd3 Ctnnb1 Kdm3a Tgfb1i1 Tcf4 Ube2i Srf Pias1 Vav3 Gsn Cdkn2a Ptk2b Carm1 Pelp1 Pias3 Tgif1 Prkdc Pias4 Med1 Akt1 Tmprss2 Xrcc6 Cdk6 Brca1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Egfr Src Ctnnb1 Casr Cdh1 Jup Fmn1 Ajuba Zyx Fyn Pik3r1 Ctnna1 Plcg1 Rhoa Ctnnd1 Akt1 Akt2 Rac1 Vasp IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Il6st Stat3 Crp Ptpn11 Stat1 Hsp90b1 Pik3r1 Lbp Hck Mcl1 Ptpre Gab1 Il6r Fgg Vav1 Mitf Tnfsf11 Cebpb Timp1 A2m Jak1 Pias1 Grb2 Sos1 Map2k6 Bcl2l1 Jun Prkcd Rac1 Fos Mapk11 Mapk14 Junb Irf1 Socs3 Pias3 Il6 Gab2 Myc Map2k4 Akt1 Jak2 Foxo1 Lmo4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Efna5 Epha2 Epha3 Epha4 Epha6 Epha7 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Atr Chek1 Ccna2 Rfc5 Rfc3 Rfc4 Mdm2 Mcm7 Rfc2 Smarcal1 Ywhab Ppp2r2b Hus1 Timeless Rpa2 Cep164 Rad17 Ppp2ca Cdc6 Atrip Tipin Brca2 Mcm2 Plk1 Rad1 Clspn Fbxw11 Ywhaz Ppp2r1a Btrc Cdc25c Cdk2 Nbn Rad51 Fancd2 Cdc25a Topbp1 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Ctnnb1 Dvl1 Dvl3 Btrc Lrp6 Csnk1d Csnk1e Wnt3a Apc Axin1 Axin2 Fzd5 Cul1 Gsk3b Skp1 Csnk1a1 Gsk3a IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Raf1 Irs2 Grb10 Ptpn11 Pik3r1 Ywhae Ptk2 Pdpk1 Igf1 Grb2 Sos1 Crk Bad Hras Igf1r Bcar1 Prkd1 Prkcd Ywhaz Nck2 Crkl Rps6kb1 Ptpn1 Akt1 Prkcz Shc1 Rack1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Vcam1 Il1b Il18 Tnf Map2k2 Mapk1 Map2k7 Map2k1 Map2k6 Pgr Mapk3 Map2k4 Map2k3 Antxr1 Casp1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Pde6b Guca1a Gnat1 Rgs9 Cnga1 Lrat Rho Gucy2f Sag Gnb1 Rdh12 Rgs9bp Grk1 Gucy2e Rpe65 Gngt1 Slc24a1 Cngb1 Guca1b Pde6a Gnb5 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccna2 Aurkb Sp1 Map2k1 Ccnb1 Ccnd1 Brca2 Plk1 Fos Chek2 Mmp2 Esr1 Cdkn2a Skp2 Crebbp Cdk1 Onecut1 Ccnb2 Foxm1 Rb1 Cks1b Tgfa Etv5 Cdk4 Nfatc3 Lama4 Cdk2 Xrcc1 Cenpa Cenpf Cdc25b Ccne1 Myc Gsk3a IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Prkce Plcb3 Lyn Plcb1 Gnai2 Fgr Hck Arrb1 Prkcg Dnm1 Gnb1 Rab5a Pdpk1 Grk2 Prkca Pik3r6 Pik3cg Cbl Cxcr1 Arrb2 Gna15 Gna14 Akt1 Pld1 Plcb2 Prkcb BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Itgb2 Itgal Fgg Ccn1 Jam3 Plat Icam1 C3 Thy1 Cd40lg Plau Vcam1 Spon2 Proc Gp1ba Fgb Fga F10 Fcgr2a Itgad F11r Icam2 Itgax Kng2l1 Itgam INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Stxbp4 Stx4 Slc2a4 Ins2 Ywhah Ywhag Ywhae Insr Prkci Ywhab Ppp1cc Sfn Asip Trip10 Ppp1r3a Vamp2 Gsk3b Gys1 Akt1 Prkcz Akt2 Lnpep Ywhaz Rhoq PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Tagln Myocd Nckap1 Actn4 Raf1 Nherf2 Nherf1 Wasf2 Sipa1 Cttn Pdgfrb Abi1 Rap1b Pdgfb Arhgap35 Map2k2 Map2k7 Map2k1 Pik3cb Brk1 Arhgdia Baiap2 Arpc1b Actr2 Actr3 Mapk10 Arpc3 Arpc2 Eif2ak2 Arpc5 Arpc4 Map2k4 Blk Jak2 Stat5a Lyn Stat3 Stat1 Fgr Pik3r1 Hck Srf Pak1 Mapk8 Mapk1 Ppp2ca Itgav Mapk3 Rhoa Pten Bcar1 Rac1 Ppp2r1a Pin1 Ptpn1 Csk Shc1 Rasa1 Src Braf Grb10 Elk1 Ptpn11 Eps8 Nck1 Ywhah Rap1a Ywhag Gab1 Pla2g4a Ywhae Dok1 Jund Rab5a Lrp1 Ywhab Grb2 Prkca Sfn Sos1 Crk Hras Plcg1 Prkcd Ywhaz Mapk9 Vav2 Rps6ka3 Abl1 Kras Nras Prkce Fyn Yes1 Ppp2r2b Dnm2 Pik3r6 Pik3cg Jun Nck2 Fos Cbl Stat5b Ptpn2 Sphk1 S1pr1 Myc Lck Sla Afdn Arap1 Rab4a Usp6nl ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 Src Ctnnb1 Pip5k1c Nectin2 Vav2 Cdh1 Nectin1 Nectin3 Ptprm Pdgfrb Pik3r1 Cldn1 Rap1a Rap1b Pdgfb Ctnna1 Ptk2 Farp2 F11r Crk Itgav Rac1 Afdn BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Rasa1 Raf1 Elk1 Cd72 Cd22 Malt1 Cd79b Bcl2a1 Pdpk1 Dok1 Bcl10 Ptprc Nfkbib Ikbkb Traf6 Ppp3cc Grb2 Ppp3cb Ikbkg Sos1 Sh3bp5 Map2k1 Hras Map4k1 Btk Vav2 Fcgr2b Nfkb1 Csnk2a1 Dapp1 Nfkbia Rela Plcg2 Blnk Lyn Pik3r1 Ets1 Mapk8 Mapk1 Mapk3 Jun Pten Map3k7 Rac1 Inpp5d Fos Ptpn6 Syk Map3k1 Chuk Mapk14 Camk2g Csk Ppp3ca Akt1 Shc1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Mcf2l Arhgef1 Arhgef2 Abr Trio Mcf2 Vav1 Arhgap35 Bcr Arhgap9 Ect2 Arhgef25 Srgap1 Arhgef5 Arhgef3 Ophn1 Rhoa Arhgdig Arhgef12 Arhgef18 Farp1 Arhgdia Vav3 Net1 Arhgef15 Arhgap4 Arhgap8 Ngef Vav2 Arhgap5 Arhgdib Cdkn1b Arhgef11 Arhgef28 Arap1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Stxbp1 Unc13b Chrna1 Snap25 Syt1 Rab3gap2 Stx1a Vamp2 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Ncstn Aph1b Gata3 Psenen Dnm1 Ccnd1 Cul1 Skp1 Rab11a Cbl Il4 Maml1 Maml2 Skp2 Itch Furin Adam12 Btrc Ptcra Dll1 Mark2 Dll3 Dll4 Kdm1a Adam10 Rbbp8 Neurl1 Yy1 Cdkn1a Mfap5 Notch1 Jag2 Jag1 Eno1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Ctbp1 Notch2 Myc Notch3 Hdac1 Dner Lnx1 Numb Eps15 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Ccnd3 Stat5a Elf1 Ccna2 Ptpn11 Ccnd2 Pik3r1 Jak3 Jak1 Grb2 Sp1 Sos1 Bcl2l1 Il2ra Lta Il2 Prf1 Il4 Faslg Il2rg Stat5b Foxp3 Gab2 Myc Lck Bcl2 Cdk6 Shc1 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Src Raf1 Stat3 Ptpn11 Erbb2 Pik3r1 Nrg2 Grb2 Mapk8 Ppp3cb Map2k2 Mapk1 Sos1 Map2k1 Bad Hras Mapk3 Jun Rac1 Pik3cb Mapk9 Prkaca Fos Mtor Chrna1 Mapk10 Nrg1 Kras Akt1 Erbb3 Nfatc4 Jak2 Nf2 Chrne Usp8 Nras Shc1 Rnf41 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Cxcr2 Rab7a Rac2 Plcb3 Lyn Plcb1 Dock2 Elmo1 Gnai2 Fgr Hck Arrb1 Prkcg Dnm1 Gnb1 Rab5a Pdpk1 Prkca Pik3r6 Pik3cg Ppp2ca Rab11a Vasp Cbl Ppp2r1a Arrb2 Gna15 Gna14 Akt1 Plcb2 Pld2 Prkcb FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc1 Sdc3 Sdc2 Sdc4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Lamb1 L1cam Cd47 Ibsp Pdgfrb Vegfa Pdgfb Fgg Sdc4 Ccn1 Itgav Spp1 Thy1 Col1a1 Col4a3 Plau Col4a1 Lama4 Lamc1 Col4a5 Vtn Fgb Sdc1 Fga F11r Sphk1 Fn1 Tgfbr2 Itga2b Col1a2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Rasa1 Irs1 Raf1 Irs2 Ptpn11 Grb2 Map2k2 Sos1 Mapkapk2 Map2k1 Hras Mapk9 Mapk11 Cdk2 Socs3 Kras Nras Prkcb Prkce Stat5a Stat3 Fyn Stat1 Socs2 Pik3r1 Stam2 Ikzf3 Stam Jak3 Jak1 Mapk8 Mapk1 Cish Mapk3 Jun Rhoa Il2ra Fos Syk Il2 Ptk2b Ifng Mapk14 Il2rg Stat5b Gab2 Myc Lck Bcl2 Shc1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Chek1 Csnk1e Npas2 Nr1d1 Nono Cry1 Cry2 Clock Bmal1 Timeless Per2 Per1 Wdr5 Bhlhe40 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Il12rb2 Il12a Map2k6 Ripk2 Cd3g Cd247 Cd3d RT1-Da Tbx21 RT1-Db1 Stat4 Il18 Il12b Eomes Cd4 Cd8b Sphk2 Cd8a Nfkb1 B2m Jak2 Nos2 Rab7a Rela Stat5a Il18r1 Il1b Stat3 Stat1 Stat6 Nfkb2 Ccr5 Gadd45g Gzma Map2k3 Il2ra Gadd45b Hlx Fos Ccl4 Il1r1 Il2 Il4 Mtor Ifng Faslg Mapk14 Il2rg Atf2 Lck BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Sdc1 Plau Itgb8 Vcam1 Itgav Itgb6 Madcam1 Itgb7 Tgfbr1 Fn1 Vtn Ccn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Irs1 Src Pxn Ptpn11 Vegfa Ptk2 Rock1 Igf1 Col11a1 Igf1r Col11a2 Casp8 Col2a1 Col3a1 Col1a1 Col4a3 Col5a2 Col6a2 Col4a1 Col5a1 Fgf2 Col4a5 Sdc1 Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Vav3 Angptl3 Cbl Mfge8 Tln1 Pi4kb Ptk2b Pik3c2a Rps6kb1 Vcl Csf1 Vtn Csf1r Hsp90aa1 F11r Akt1 Fn1 Tgfbr2 Col1a2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Crebbp Tubb2a Mef2d Acss1 Myod1 Cdkn1a Hdac4 Fhl2 Tp53 Sirt3 Sirt2 Sirt1 Bax Ppargc1a Foxo4 Foxo3 Foxo1 Xrcc6 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rara Nrip1 Prkcg Ncoa2 Ncoa1 Mapk8 Prkca Mapk1 Mapk3 Prkaca Vdr Crebbp Cdk1 Mnat1 Ccnh Mapk14 Cdk7 Rbp1 Hdac3 Rxrb Rxra Hdac1 Rarg Akt1 Rxrg HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Cdkn2a Vhl Eloc Rbx1 Hif3a Os9 Cops5 Naa10 Cul2 Hsp90aa1 Tp53 Arnt Hif1an Egln2 Egln3 Hif1a Rack1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Foxa1 Foxa2 Foxa3 Col18a1 Nrip1 Cebpb Ap1b1 Ar Shh Sp1 Dscam Jun Tff1 Apob Atp5pf Fos Xbp1 Esr1 Sod1 Pou2f1 Crebbp Ndufv3 Prdm15 Ins2 Vtn Pisd Sftpd Nfib Cdkn1b Nfia Nfic Scgb1a1 Nr2f2 Gcg C4bpb Serpina1 Nkx3-1 Brca1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Tab2 Ror2 Yes1 Rock1 Camk2a Mapk8 Rhoa Csnk1a1 Map3k7 Rac1 Mapk9 Dvl1 Dvl3 Mapk10 Nfatc2 Arrb2 Wnt5a Nlk Pparg Cthrc1 Fzd2 Fzd5 Prkcz Daam1 Flna Fzd6 Chd7 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Src Gnai1 Plcb3 Gnai3 Plcb1 Gnaz Gnao1 Gnai2 Pik3r1 Gnb1 Hbegf Nos3 Igf1 Gna13 Grb2 Sos1 Hras Msn Igf1r Rhoa Bcar1 Mmp2 Esr1 Esr2 Mmp9 Rock2 Mapk11 Gna11 Gna15 Pelp1 Gna14 Gnaq Kras Akt1 Gnal Plcb2 Strn Nras Shc1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Myog Mdfic Igf2bp1 Cby1 Vcan Id2 Fgf4 Zcchc12 Tbl1xr1 Kcnip4 Tnik Adcy7 Ccnd2 Mt-co2 Camk4 Ywhah Tle4 Ywhag Med12 Ywhae Tle2 Mitf Krt1 Ruvbl2 Tle5 Dkk4 Ar Ywhab Chd8 Ncoa2 Smarca4 Tcf7 Tbl1x Sfn Sp5 Cdx4 Axin2 Cdx1 Ccnd1 Ctnnbip1 Klf4 Hbp1 Pitx2 Ywhaz Myf5 Dvl3 Tle1 Dkk1 Ctnnb1 Tcf4 Cdh1 Incenp Xpo1 Tcf7l2 Ccn1 Apc Jun Cul1 Skp1 Mmp2 Cdkn2a Mmp9 Tcf7l1 Btrc Tbxt Lef1 Hdac2 Ctbp1 Myc Tert Hdac1 Neurog1 Cacna1g EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Irs2 Plcg2 Stat5a Lyn Ptpn11 Stat1 Pik3r1 Rap1a Gab1 Grb2 Mapk8 Sos1 Bcl2l1 Hras Epor Epo Plcg1 Inpp5d Ptpn6 Tec Cbl Crkl Btk Vav2 Mapk14 Stat5b Socs3 Bcl2 Nfkb1 Jak2 Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map3k10 Tab2 Atm Map3k1 Mapk11 Mapk14 Txn Gadd45a Traf6 Map3k3 Camk2b Traf2 Map2k6 Gadd45g Map2k3 Gadd45b Map3k7 Rac1 Taok1 Taok3 Map3k6 Map3k4 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Cdkn2a Skp2 Pin1 Supt7l Pak2 Zbtb17 Kat5 Max Ruvbl2 Ppp2ca Ruvbl1 Myc Axin1 Gsk3b Hbp1 Actl6a Kat2a Ppp2r5a Taf9 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Gnai1 Gnai3 Gnaz Gnao1 Gnai2 Pdgfrb Vegfa Ptgs2 Pdgfb Abcc1 Sphk1 Mapk1 S1pr1 Mapk3 Plcg1 Rhoa Rac1 Plcb2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Prnp Lama1 Pla2g2a Src Slit2 Smad2 Serpinc1 Lyn Cripto Tgfb1 Fyn Yes1 Fgr Tgfb3 Nrg1 Hck Fgf2 Vegfa App Fgfr1 Lck Blk Tgfbr1 Tgfbr2 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Gnai1 Src Raf1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Adcy7 Pla2g4a Prkca Map2k2 Crk Map2k1 Hras Prkcd Col3a1 Ednrb Ednra Mmp1 Adcy3 Adcy4 Adcy2 Adcy8 Adcy5 Adcy6 Edn2 Edn3 Prkch Cysltr2 Cysltr1 Prkcq Jak2 Plcb2 Prkcb Prkce Plcb3 Edn1 Plcb1 Trpc6 Prkcg Slc9a1 Mapk8 Slc9a3 Mapk1 Mapk3 Jun Rhoa Bcar1 Rac1 Fos Ptk2b Mapk14 Gna11 Gna15 Gna14 Gnaq Akt1 Gnal Col1a2 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Pgf Vegfa Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Trpc6 Fyn Tjp1 Pik3r1 Nck1 Grb2 Mapk8 Bad Jun Plcg1 Rac1 Pik3cb Mapk9 Nck2 F2rl2 Mapk10 Arrb2 Prkci Nphs2 Map2k4 Nphs1 Akt1 Prkcz Cd2ap Kirrel1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Tiam1 Egfr Gnai1 Src Pxn Nherf2 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Adcy7 Gab1 Ptk2 Crk Hras Plcg1 Gsk3b Prkcd Pik3cb Casp3 Adcy3 Adcy4 Adcy2 Adcy8 Adcy5 Adcy6 Nfkb1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Pld2 Prkce Nfkbia Plcb3 Rela Arhgef1 Lyn Pik3r1 Gnb1 Hbegf Gna13 Jun Rhoa Bcar1 Prkd1 Rac1 Fos Mmp2 Ptk2b Mmp9 Gna11 Gna15 Gna14 Gnaq Akt1 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Lama1 Lama3 Col18a1 Vegfa Col11a1 Col11a2 Mdk Jam2 Col2a1 Cd81 Col3a1 Col1a1 Col4a3 Col5a2 Vcam1 F13a1 Col6a2 Igsf8 Cd14 Thbs2 Col4a1 Col5a1 Lamc1 Col4a5 Tgm2 Lama5 Itga10 Itga7 Itga8 Itga3 Itga5 Itga6 Itga9 Itgb1 Nid1 Lamb2 Itga1 Cspg4 Lamb3 Itga2 Lamb1 Fgg Itgav Spp1 Plau Lama4 Vtn Fgb Fga Fn1 Col1a2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Egfr Src Ctsg Itgb2 Fpr1 Klk4 Fpr3 Fpr2 Dock1 Serpine1 Gpld1 Mmp12 Pdgfrb Mmp13 Ctrc Vldlr Fgg Lrp1 Crk Itgav Bcar1 Rac1 Mmp9 Plau Tgfb1 Hgf Plg Vtn Elane Fgb Fga Itga3 Itga5 Fn1 Itgb1 Itgam VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Rbl1 Id2 Pdgfrb Max Gadd45a Sp1 Ccnd1 Cflar Ccl5 Smad2 Smad3 Smad4 Zbtb17 Hdac3 Cdkn1a Wnt5a Dntt Cdkn1b Lgals1 Itga6 Itgb1 Dkk1 Itgb4 Erbb2 Spi1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Tmem126a Sfrp1 Tbp Csde1 Tsc2 Hmgcs2 Nfyb Irf8 Nfya Ptpa Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Cebpa Myc Hdac1 Bcl2 Cdkn2b Foxo3 Creb1 Col1a2 Brca1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Egfr Areg Tgfa Erbb2 Erbb4 Nrg1 Ereg Hbegf Egf Nrg2 Btc Hsp90aa1 Nrg4 Nrg3 Erbb3 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Camk4 Nr3c1 Ranbp2 Xpo1 Ywhae Hdac4 Gnb1 Srf Ube2i Ran Ywhab Grk2 Esr1 Ankra2 Tubb2a Rfxank Mef2c Hdac3 Hdac11 Bcl6 Hdac10 Hdac7 Gata1 Hsp90aa1 Gata2 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Tab2 Ctnnb1 Ywhae Pdpk1 Camk2a Ccn2 Grb2 Sos1 Ppp2ca Fkbp1a Map3k7 Itch Smad2 Rps6kb1 Smad3 Strap Dynlrb1 Smad4 Daxx Dab2 Dact2 Tgfb1 Wwp1 Tgfbrap1 Tgfb3 Zfyve16 Ppp2cb Arrb2 Tgfbr3 Ppp1ca Sptbn1 Ppp2r2a Smad7 Cav1 Rnf111 Ppp1r15a Zfyve9 Bambi Axin1 Nedd4l Smurf1 Tgfbr1 Tgfbr2 Xiap Shc1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Map3k1 Lcp2 Map3k8 Mapk8 Dbnl Crk Jun Map2k4 Grap2 Lat Map3k7 Map4k1 Crkl Prkcb ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Prkce Nr4a1 Map3k8 Camk4 Ywhah Ywhag Xpo1 Prkcg Ywhae Ran Ywhab Mapk8 Prkca Sfn Bad Bcl2l1 Mapk3 Chp1 Rcan2 Gsk3b Fkbp1a Prkcd Csnk1a1 Ywhaz Mapk9 Prkaca Casp3 Pim1 Cabin1 Crebbp Map3k1 Mef2d Akap5 Mapk14 Nfatc3 Nfatc2 Prkch Fkbp8 Prkcq Kpna2 Bcl2 Kpnb1 Prkcz Bax Csnk2a1 Prkcb TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Map3k8 Ptpn11 Nck1 Rap1a Malt1 Vav1 Pdpk1 Bcl10 Ptprc Ikbkb Traf6 Grb2 Prkca Ikbkg Sos1 Hras Plcg1 Grap2 Itk Map4k1 Cd3g Cd247 Cd3d Cd28 RT1-Da Cd86 Lcp2 Cd80 RT1-Db1 Prkcq Cd4 Kras Zap70 Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Pten Inpp5d Ptpn6 Cbl Chuk Map3k14 Trpv6 Csk Dbnl Gab2 Sla2 Orai1 Lck Stim1 Akt1 Stk39 Lat Flna Rassf5 Fyb1 Sh3bp2 Shc1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Pik3r1 Nck1 Vegfa Nos3 Cav1 Pdpk1 Hsp90aa1 Nrp1 Shc2 Prkca Nrp2 Mapk1 Pgf Mapk3 Plcg1 Akt1 Cd2ap Prkaca Hif1a Cbl Prkcb EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Egf Mtor Egfr Grb2 Edn1 Sos1 Hras Ednra Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Ift88 Kif3a Stk36 Gnai1 Sufu Foxa2 Spop Gnai3 Gnaz Gnao1 Gnai2 Xpo1 Gnb1 Gli2 Shh Pias1 Smo Ptch1 Map2k1 Sap18 Gsk3b Prkcd Csnk1a1 Fbxw11 Csnk1g3 Prkaca Csnk1g1 Csnk1g2 Rbbp7 Crebbp Btrc Csnk1d Arrb2 Csnk1e Hdac2 Hdac1 Akt1 Lgals3 Rab23 Gli1 Mtss1 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Grb10 Ptpn11 Pik3r1 Nck1 Exoc3 Eif4ebp1 Exoc5 Pdpk1 Exoc6 Dok1 Exoc2 Grb2 Sos1 Crk Exoc7 Hras Sh2b2 Inpp5d Nck2 Cbl Ptpra Rps6kb1 F2rl2 Ins2 Grb14 Sgk1 Insr Prkci Cav1 Ptpn1 Trip10 Akt1 Prkcz Akt2 Rhoq Foxo3 Shc1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfc Pdgfra Pdgfrb Pdgfb EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Tiam1 Src Epha2 Inppl1 Vav2 Acp1 Pik3r1 Arhgap35 Ptk2 Pak1 Grb2 Rhoa Bcar1 Efna1 Rac1 Vav3 Shc1 Cbl ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Egfr Src Nckap1 Raf1 Braf Wasf2 Elk1 Arf4 Ppp5c Eps8 Diaph3 Atf1 Zfp36 Abi1 Ywhah Map3k2 Ywhag Gab1 Myl11 Ywhae Map2k5 Dusp6 Pdpk1 Rab5a Ralgds Egf Ywhab Grb2 Prkca Map2k2 Sos1 Sfn Dusp1 Egr1 Map2k1 Bad Hras Rps6ka5 Prkcd Ywhaz Pik3cb Mapk9 Brk1 Baiap2 Arpc1b Actr2 Vav2 Actr3 Mef2c Arpc3 Arpc2 Arpc5 Arpc4 Rps6ka3 Map2k4 Kras Prkcz Pld1 Nras Pld2 Capn2 Pebp1 Rin1 Stat3 Stat1 Rala Pik3r1 Srf Slc9a1 Mapk8 Mapk1 Ppp2ca Bcl2l1 Mapk3 Jun Rac1 Fos Mtor Ppp2r1a Map3k1 F2rl2 Sh2d2a Atf2 Ppp2r2a Smad1 Rps6 Rictor Akt1 Mapkap1 Creb1 Mlst8 Usp6nl LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Nudc Cdk5 Vldlr Map1b Ywhae Ppp2r5d Katna1 Pafah1b3 Pafah1b2 Lrp8 Lrpap1 Pafah1b1 Dab1 Dync1h1 Dynlt1 Cdk5r1 Rhoa Ndel1 Abl1 Reln Dcx Csnk2a1 Rac1 Pla2g7 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Atf5 Itga1 Src Ccna2 Cdk2 Cdkn1a Ccne1 Rock1 Agt Mapk1 Egr1 Mapk3 Rhoa Bcar1 Rac1 Ptp4a3 Ptp4a1 Itgb1 Rabggta Rabggtb EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Tiam1 Rgs3 Src Ephb1 Lyn Ephb2 Ptpn13 Efnb1 Fyn Efnb2 Yes1 Fgr Pik3r1 Hck Dnm1 Mapk8 Map2k4 Lck Blk Map3k7 Rac1 Nck2 Itga2b VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Itga1 Col1a1 Itga2 Mapk11 Mapk14 Pik3r1 Rps6ka1 Vegfd Vegfc Grb2 Mapk1 Sos1 Flt4 Crk Mapk3 Map2k4 Itga5 Akt1 Fn1 Itgb1 Creb1 Col1a2 Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Egfr Src Pxn Tshr Adap1 Adrb2 Git1 Nck1 Acap1 Arrb1 Agtr1 Egf Arf6 Efna1 Gulp1 Epha2 Fbxo8 Acap2 Lhcgr Arap2 Hgf Arrb2 Gna11 Gna15 Gna14 Met Gnaq Cyth2 Itga2b Cyth3 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Ada Tp63 Serpine1 Ccna2 Kat5 Sp1 Sfn Ntrk1 Plk3 Plpp1 Hey2 Fas Prkacb Mapk11 Rb1 Pfdn5 Tuba1a Ccne2 Cdk2 Pea15 Il1rap Ndufs2 Cdkn1a Hagh Gramd4 Jag2 Aen Dcp1b Gata1 Rnf43 Dedd Flot2 Afp Hsf1 Wt1 Nedd4l Bak1 Sirt1 Abl1 Ube4b Tp73 Bax Nsg1 Gdf15 Rela Chek1 Wwox Mdm2 Jak1 Bub1 Ccnb1 Bin1 Brca2 Plk1 Bcl2l11 Itch Pin1 Cdk1 Mapk14 Il4r Myc Serpina1 Rad51 Foxo3 Rchy1 Casp2 Cdk6 Rack1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Cxcl13 Src Gnai1 Raf1 Gnai3 Gnaz Gnao1 Gnai2 Pik3r1 Arrb1 Dnm1 Gnb1 Pdpk1 Map2k2 Mapk1 Map2k1 Map2k6 Hras Mapk3 Map2k3 Pik3cb Mtor Ccl11 Mapk11 Mapk14 Cxcl9 Rictor Kras Akt1 Cxcl11 Cxcl10 Mapkap1 Cxcr3 Nras Pf4 Mlst8 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Cnksr1 Il3ra Prkacb Srp9 Stat5a Ptpn11 Pik3r1 Stat5b Id1 Ywhag Cebpb Csf2rb Grb2 Cish Gab2 Bcl2l1 Osm Hdac1 Jak2 Ywhaz Inpp5d Prkaca Shc1 Pim1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Egfr Src Nherf1 Gna12 Gnai2 Dnm1 Nos3 Rock1 Egf Sele Grk2 Prkca Icam1 Prkcd Rab11a Vcam1 Mapk11 Tgm2 Prkch Prkcq Arr3 Prkcz Blk Plcb2 Prkcb Gnb5 Prkce Ptgdr Ptgir Arhgef1 Lyn Tbxa2r Grk3 Fyn Fgr Yes1 Hck Prkcg Gnb1 Gna13 Pik3r6 Pik3cg Rhoa Rac1 Prkaca Syk Mapk14 Arrb2 Gna11 Gna15 Gna14 Gnaq Lck Akt1 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Itgb4 Lamb2 Egfr Lama1 Lamb3 Lama3 Lamb1 Cdh1 Col17a1 Pmp22 Erbb2 Pik3r1 Ywhah Ywhag Ywhae Egf Ywhab Grb2 Prkca Sfn Hras Mst1r Rac1 Ywhaz Rps6kb1 Mst1 Lama4 Lamc1 Il1a Lama5 Met Rxrb Rxra Casp7 Akt1 Erbb3 Rxrg Itga6 Itgb1 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Irs1 Raf1 Srebf1 Braf Ywhah Ywhag Eif4ebp1 Ywhae Eif4a1 Pdpk1 Ywhab Ikbkb Prkca Map2k2 Sfn Map2k1 Eif4e Hras Ppargc1a Ywhaz Cdk2 Rps6ka1 Yy1 Cycs Rptor Kras Pld1 Nras Pld2 Akt1s1 Prr5 Rraga Ddit4 Rragb Rragc Rragd Tsc1 Eif4b Ulk1 Ulk2 Rb1cc1 Mapk1 Rrn3 Tsc2 Poldip3 Pdcd4 Mapk3 Bnip3 Atg13 Eef2 Eef2k Fbxw11 Mtor Rps6kb1 Btrc Sgk1 Ccne1 Rictor Akt1 Mapkap1 Mlst8 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Btrc Chuk Nfkb2 Map3k14 Nfkb1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Egfr Tp63 Col18a1 Serpine1 Atf3 Bcl2a1 Pou4f1 E2f3 Pou4f2 Cd82 Sp1 Plk3 Bid Kat2a Vdr Fas Crebbp Rb1 Ctsd Cdkn1a Afp Bak1 Tp73 Bax Gdf15 Foxa1 Ddit4 Mdm2 Cse1l Apc Ccnb1 Pten Drosha Spp1 Ccnk Pcbp4 Tap1 Bdkrb2 Ccng1 Hic1 Ppp1r13b Igfbp3 Msh2 Mmp2 Tnfrsf10b Sh2d1a Sesn1 Steap3 Tada2b Fdxr Ddx5 Btg2 Rrm2b Tp53bp2 Prmt1 Bcl2l14 Carm1 Gpx1 Bcl2l2 Perp Cav1 Bnip3l Rnf144b Triap1 Irf5 Lif Aifm2 Dgcr8 Tp53 Htt Scn3b Pidd1 Zfp385a Pms2 Cx3cl1 Pycard Pcna Mlh1 Tp53inp1 Tigar Rchy1 Nlrc4 Casp1 Prdm1 Prkab1 Apaf1 Ppm1j Vcan Serpinb5 Gadd45a Smarca4 Dusp5 Sfn Dusp1 Epha2 Hgf Edn2 Met Dkk1 Mcl1 Tsc2 Bcl2l1 Jun Nfyb Nfya Nfyc Ndrg1 Tgfa Bcl6 Hdac2 Bcl2 Casp6 E2f1 Taf9 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkce Adcy3 Adcy4 Adcy7 Adcy2 Adcy8 Adcy5 Adcy6 Rps6ka5 Lpar4 Prkaca Gnal Creb1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Tiam1 Rab7a Egfr Src Slit1 Ctnnb1 Cbll1 Dsp Gna12 Cdh1 Cables1 Jup Igf2 Gdnf Robo1 Fyn Zbtb33 Gfra1 Snx1 Ctnna1 Rab5a Egf Nme1 Gna13 Ntrk2 Dnm2 Hras Igf1r Ctnnd1 Arf6 Rac1 Ptpn6 Casp3 Crebbp Mmp7 Cdh2 Adam10 Hgs Ptpn1 Met Abl1 Bdnf Ret Rin2 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Arhgef7 Ajuba Aurkaip1 Aurkb Oaz1 Git1 Cpeb1 Dlgap5 Fzr1 Tdrd7 Pak1 Mdm2 Ran Gadd45a Ndel1 Gsk3b Prkaca Tpx2 Tacc3 Ckap5 Aurka Cenpa Cdc25b Ppp2r5d Tp53 Akt1 Tacc1 Brca1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Rela Stat5a Pik3r1 Fcamr Traf3 Jak3 Cd40 C4bpa Traf6 Tdp2 Mapk8 Birc2 Pik3r6 Pik3cg Bcl2l1 Jun Birc3 Pik3cb Mapk9 Il4 Cblb Map3k1 Cd40lg Mapk10 Mapk11 Map3k14 Mapk14 Traf2 Myc Map2k4 Akt1 Nfkb1 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Ncoa2 Esr2 Ncoa1 Smarca4 Nr0b2 Nr0b1 Smarcb1 Zfp709 Uba3 Smarce1 Nedd8 C3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkc Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Akt1s1 Ywhah Ywhag Ywhae Tsc1 Ywhab Sfn Stk11ip Tsc2 Stk26 Mark4 Crtc2 Map2 Gsk3b Stradb Smarcd3 Ywhaz Cab39 Prkaca Strada Etv4 Stk11 Esr1 Psen2 Mtor Sik1 Brsk2 Ezr Brsk1 Smad4 Mark2 Cdc37 Ctsd Hsp90aa1 Tp53 Myc Rptor Creb1 Mlst8 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb1 Ephb2 Ephb3 Efnb1 Efnb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Raf1 Braf Elk1 Ntf3 Rap1a Rap1b Map3k2 Map2k5 Srf Trpv1 Mapk1 Mapkapk2 Egr1 Map2k1 Map2k6 Hras Mapk3 Cdk5r1 Rps6ka5 Map2k3 Prkcd Fos Mef2c Mapk14 Cdk5 Rps6ka1 Kras Rit1 Rit2 Ehd4 Creb1 Nras TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Tab2 Rela Tnik Stat1 Adam17 Ikbkb Birc2 Ikbkg Map3k3 Map2k7 Smpd2 Birc3 Map2k3 Map3k7 Casp8 Ripk1 Fadd Map3k1 Nrk Map4k5 Map4k3 Chuk Tnfrsf1b Cyld Map4k2 Rffl Sqstm1 Nsmaf Madd Prkci Cav1 Smpd1 Txn Tnfrsf1a Bag4 Tnf Traf2 Prkcz Nfkb1 Rack1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Hadh Foxa1 Foxa2 Foxa3 Tfrc Nr3c1 Cebpb Sp1 Ins2 G6pc1 Pklr Tat Aldob Hnf4a Nkx2-1 F2 Cebpa Acadvl Hmgcs1 Ttr Dlk1 Igfbp1 Slc2a2 Afp Ucp2 Nf1 Pck1 Acadm Gck Cpt1a Akt1 Bdh1 Abcc8 Kcnj11 Alb Hnf1a Creb1 Cpt1b Cpt1c CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Tiam1 Enah Src Raf1 Braf Eps8 Diaph3 Dlg1 Map2k7 Map2k6 Hras Gsk3b Mapk9 Arhgdia Baiap2 Iqgap3 Arpc1b Actr2 Vav2 Actr3 Pak2 Arpc3 Arpc2 Arpc5 Arpc4 Map3k11 Map2k4 Prkcz Pld1 Pak4 Cdc42bpa Prkce Ctnnb1 Septin2 Pax6 Arhgef7 Hes5 Cdh1 Tnk2 Arhgef6 Pik3r1 Yes1 Ctnna1 Pak1 Mapk8 Mapk1 Apc Cfl1 Exoc7 Mapk3 Jun Bcar1 Map2k3 Rac1 Myl2 Limk1 Limk2 Cbl Mtor Map3k1 Rps6kb1 F2rl2 Mapk14 Atf2 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Gnai1 Src Pxn Gnai3 Gnaz Gnao1 Gnai2 Ptpn11 Rap1b Dnm1 Vav1 Ptk2 Pdpk1 Ptprc Stat2 Rhob Grk2 Crk Bad Pik3cb Cd3g Cd247 Cd3d RT1-Da RT1-Db1 Ssh1 Cxcr4 Cd4 Arr3 Prkcz Blk Jak2 Plcb2 Plcb3 Stat5a Lyn Plcb1 Rgs1 Ubqln1 Stat3 Vps4a Fyn Stat1 Fgr Vps4b Pik3r1 Yes1 Hck Grk6 Gnb1 Cxcl12 Pak1 Gna13 Pik3r6 Pik3cg Cfl1 Rhoa Bcar1 Rac1 Inpp5d Limk1 Ptpn6 Mtor Ptk2b Mmp9 Itch Ralb Stat5b Hgs Arrb2 Csk Lck Rictor Akt1 Foxo1 Mapkap1 Rack1 Mlst8 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Th Raf1 Mapk11 Mapk14 Etv1 Ywhah Tcf3 Cdc25b Lsp1 Ywhag Ywhae Srf Ywhab Hspb1 Mapkapk3 Mapkapk2 Sfn Tsc2 Ywhaz Creb1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Ncstn Dkk1 Aph1b Ctnnb1 Psenen Psen1 Nedd4 Dkk2 Tle5 Mapk1 Apc Mapk3 Jun Ccnd1 Gsk3b Csnk1a1 Map3k7 Fbxw11 Fos Dvl1 Crebbp Btrc Dll1 Tle1 Lrp6 Adam10 Notch1 Nlk Wif1 Ppp2r5d Wnt1 Fzd1 Ctbp1 Myc Axin1 Hdac1 Kremen2 Csnk2a1 Hnf1a Ppard VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Itgb4 Ada Cables1 Tp63 Serpinb5 Dhrs3 Traf4 Mdm2 Ogg1 Spata18 Gadd45a Shh Ikbkb Tfap2c Nqo1 Sp1 Noc2l Ssrp1 Dicer1 Plk1 Hbp1 Prkcd Smarcd3 Vdr Igfbp3 Mfge8 Cdkn2a Fas Itch Btrc Egr2 Fdxr Chuk Wwp1 Cdkn1a Jag1 Aen Perp Flot2 Itga3 Abl1 Bax Gdf15 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Il1b Stat3 Ptpn11 Stat1 Pik3r1 Ifngr1 Rap1a Rap1b Dapk1 Cebpb Camk2a Jak1 Pias1 Mapk1 Map2k1 Mapk3 Irf9 Prkcd Camk2d Cbl Crkl Mtor Crebbp Ifng Map3k1 Irf1 Ptpn2 Camk2g Smad7 Map3k11 Pias4 Camk2b Akt1 Jak2 Casp1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Cltb Arfgap1 Cd4 Ap2m1 Arf1 Gbf1 Uso1 Gga3 Rac1 Kdelr1 Asap1 Cyth2 Ap2a1 Clta Arfip2 Pld2 Gosr2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Tab2 Myd88 Rela Irak4 Il1b Pik3r1 Ikbkb Traf6 Mapk8 Ikbkg Map3k3 Map2k6 Jun Map3k7 Il1r1 Ube2v1 Ticam2 Irak3 Erc1 Tollip Chuk Il1r2 Il1rn Il1rap Sqstm1 Il1a Prkci Prkcz Nfkb1 Ube2n Irak1 Casp1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Nr4a1 Gata3 Pomc Ppp5c Ywhah Nr3c1 Ncoa2 Smarca4 Sele Ncoa1 Il5 Sfn Egr1 Icam1 Cdk5r1 Gsk3b Bglap Mapk9 Il13 Prkacb Crebbp Mapk10 Mapk11 Tbx21 Mmp1 Cdk5 Irf1 Cdkn1a Fkbp4 Afp Il6 Bax Nfkb1 Rela Stat5a Stat1 Spi1 Fgg Mdm2 Mapk8 Tbp Mapk1 Mapk3 Jun Prkaca Fos Il2 Il4 Pou2f1 Ifng Csf2 Krt14 Prl Mapk14 Nr1i3 Tsg101 Kmt5b Sgk1 Stat5b Fkbp5 Csn2 Sumo2 Pou1f1 Cga Pck2 Krt17 Hsp90aa1 Hdac2 Pbx1 Smarcc2 Tp53 Hdac1 Akt1 Smarcc1 Creb1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Ube2d3 Egfr Src Raf1 Arhgef7 Pik3r1 Lrig1 Synj1 Dnm1 Ptk2 Itsn1 Rab5a Egf Grb2 Sos1 Hras Pik3cb Ube2d1 Cbl Sh3gl2 Cblb Tsg101 Hgs Stambp Amph Spry2 Chmp3 Epn1 Kras Ube2d2 Zfyve28 Sh3kbp1 Eps15 Usp8 Nras Shc1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Tfe3 Sult2a1 Ranbp1 Apaf1 Rbl1 Ces2h Atm Mcm3 Ces4a Dhfr Serpine1 Orc1 Ces5a Ccna2 Rrm2 E2f6 E2f7 E2f3 Sp1 Hbp1 Kat2a Crebbp Rb1 Wasf1 Ccne2 Cdk2 Rbbp8 Yy1 Cdkn1a E2f5 Cdkn1b Cbx5 Sirt1 Tp73 Ccnd3 Mcl1 Cdc6 Hic1 Cdkn2a Plau Cdk1 Rbl2 Smarca2 Xrcc1 Ccne1 Trim28 Cebpa Myc Hdac1 Casp7 E2f1 Uxt Tfdp2 Ces1d Cdc25a Cdkn2c Topbp1 Tyms Mybl2 Brca1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Ube2d3 Nfkbia Atm Rela Erc1 Btrc Chuk Cyld Xpo1 Malt1 Bcl10 Tnfrsf1a Ran Ikbkb Traf6 Birc2 Tnf Prkca Ikbkg Nfkb1 Ripk2 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Efna5 Fyn TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Map3k8 Rap1a Malt1 Vav1 Pdpk1 Bcl10 Ptprc Ikbkb Traf6 Grb2 Prkca Ikbkg Sos1 Hras Plcg1 Grap2 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Lcp2 Cd80 Prkcq Cd8b Kras Cd8a B2m Zap70 Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Ptpn6 Cbl Chuk Map3k14 Trpv6 Csk Orai1 Lck Stim1 Akt1 Lat Rassf5 Shc1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Egfr Xrcc5 Atm Terf1 Smg6 Ywhae Tinf2 Max Parp2 Pot1 Acd Egf Znfx1 Terf2ip Hnrnpc Sp1 Pinx1 Sap18 Ccnd1 Sp3 Rbbp7 Esr1 Smad3 Irf1 Cdkn1b Wt1 Ube3a Abl1 Nfkb1 Mxd1 Blm Hus1 Mapk1 Mapk3 Jun Rad1 Fos Il2 Mtor Ifng Rps6kb1 Tgfb1 Mre11 Hsp90aa1 Hdac2 Nbn Nr2f2 Myc Tert Hdac1 Terf2 Akt1 Rad50 E2f1 Xrcc6 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Raf1 Ccna2 Ccnd2 Myod1 Mitf Cebpb Ubtf E2f3 Smarca4 Smarcb1 Tgfb2 Suv39h1 Gsc Brd2 Pax3 Ccnd1 Aatf Rbp2 Bglap Atf7 Runx2 Ckm Mapk9 Taf1 Crebbp Mef2c Mapk11 Rb1 Cdk4 Cdk2 Hdac3 Cdkn1a Met Cdkn1b Pparg Sirt1 Abl1 Ccnd3 Elf1 Spi1 Mdm2 Tbp Ppp2ca Jun Cdkn2a Skp2 Csf2 Mapk14 Atf2 Ccne1 Cebpa Sftpd Ctbp1 Hdac1 Cbx4 E2f1 Cdk6 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Smad2 Map3k1 Smad3 Smad4 Tgfbrap1 Ube2i Pias4 Mapk1 Kpna2 Mapk3 Kpnb1 Ctdsp1 Ppm1a Nup153 Ctdspl HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Id2 Serpine1 Tf Tfrc Vegfa Ncoa2 Ncoa1 Sp1 Arnt Hif1a Plin2 Adm Cp Crebbp Pfkfb3 Furin Nt5e Smad3 Pgm1 Fech Smad4 Pkm Aldoa Cxcr4 Abcb1a Pfkl Rora Hk2 Bhlhe41 Hdac7 Igfbp1 Npm1 Gck Nos2 Gata2 Itgb2 Edn1 Mcl1 Cops5 Ets1 Cxcl12 Bnip3 Jun Epo Bhlhe40 Tff3 Egln3 Fos Cited2 Ndrg1 Pgk1 Slc2a1 Abcg2 Hnf4a Hmox1 Eno1 Tert Lep Akt1 Creb1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Arhgef2 Fyn Pik3r1 Rap1a Vldlr Map1b Mapk8 Lrp8 Lrpap1 Pafah1b1 Dab1 Map2k7 Grin2b Cdk5r1 Gsk3b Reln Nck2 Cbl Crkl Cdk5 Grin2a Mapk8ip1 Map3k11 Itga3 Akt1 Itgb1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Fadd Map3k1 Chuk Pik3r1 Dap3 Smpd1 Ikbkb Mapk8 Mapk1 Ikbkg Traf2 Mapk3 Map2k4 Cflar Pik3cb Casp8 Ripk1 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Crh Mapk8 Mapk11 Mapk14 Mapk9 Gnal Gnb1 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Itga1 Egfr Src Atr Stat5a Stat3 Stat1 Pdgfrb Pik3r1 Stat6 Vegfa Pdgfb Gab1 Jak3 Egf Jak1 Pias1 Grb2 Sos1 Pik3cb Crebbp Ins2 Hgf Eif2ak2 Stat5b Ptpn2 Csf1 Insr Ptpn1 Csf1r Met Lman1 Kpna2 Kpnb1 Itgb1 Rab4a Shc1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Tab2 Mapk1 Gsk3b Map3k7 Ppm1a Ctdspl Bmp4 Smad4 Zfyve16 Ppp1ca Bmp7 Smad7 Ppp1r15a Bmpr2 Smad1 Bambi Grem1 Ahsg Sostdc1 Smad9 Rgma Hjv Chrd Fst Smurf1 Smad5 Nog Ctdsp1 Bmpr1a Xiap Bmp6 Bmp2 Smad6 Chrdl1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events F2rl2 Rock2 Gna11 Gnb1 F2 Gna15 Rock1 Gna14 Gna13 Gnaq Rhoa Myl2 Plcb2 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Prkaca Ctnnb1 Gli1 Kif7 Med6 Gli2 Grk2 Ywhae Ptch1 Sap18 Dyrk1a Sufu Boc Arrb2 Kif27 Med23 Med12 Med1 Ccnb1 Dhh Hhip Ihh Stk36 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Ar Hdac1 Akt1 Hspb1 Pik3r1 Ptk2 Creb1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Mapk1 Irf2bp1 Ets1 Dynlrb1 Kpnb1 Mapk3 Ube2i Myc Tp53 Skp1 Pdk1 Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d2 Ube2d1 Nup153 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Junb Smad6 Daxx Hnf4a Ing2 Xpo1 Pdpk1 Ctcf Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Runx3 Runx1 Cd44 Runx2 Rb1 Tgfbr3 Prkar2a Trim33 Map2k3 Mef2c Brca1 Zfyve9 Cdkn1a Tgfbr2 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Rps6kb1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Enah Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Jak3 Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Bdh1 Ldhb Tuba4a Zdhhc17 Golga5 Ctla4 Cd3g Actr10 Cd3d Dusp3 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Mpzl1 Map2k1 Hnrnph3 Nedd9 Stat1 Dbnl Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Sdcbp Cd86 Cd84 Sh2d2a Cd82 Snrnp70 Cd80 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Hgs Stk39 Flnb Anxa2 Raf1 Inpp5d Shc1 Stk4 Acly Ripk2 Elmo1 Prp4k Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Adam9 Dnm2 Epha3 Pkm Lck Evl Lcp2 Sos1 Ywhaz Lpxn Atp1a1 Src Atp1a3 Ptpn6 Trim25 Ptpn3 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Stat1 Rps6kb1 Mapk8 Src Gsk3b Nfkbia Grb2 Ikbkb Ncoa1 Khdrbs1 Shc1 Chuk Runx2 Crp Jak3 Erbb2 Irs1 Pde3a Eif4ebp1 Socs7 Prkaa1 Prkaa2 Gnaq Slc2a4 Esr1 Fyn Jak1 Nos3 Rps6 Cfl2 Egfr Akt1 Eif4e Plcg1 Gsk3a Cdk5 Plcg2 Ptk2 Lep Limk1 Prkce Rps6ka2 Mapk1 Acacb Igf1r KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Ptpru Gys1 Csf2rb Stat1 Jak2 Sh3kbp1 Mapk8 Mad2l1 Fgr Hck Prkcb Rps6ka1 Kit Gsk3b Tnfrsf10b Prkca Spred1 Ezr Spred2 Crk Grb7 Mtor Epor Mapk12 Yes1 Rela Kitlg Rdx Msn Stat5a Stat5b Fes Cdk2 Raf1 Hras Inpp5d Crkl Akt1 Cblb Pik3r1 Atf2 Wipf1 Mapk1 Rasa1 Sos1 Rps6kb1 Src Grap Ptpn11 Mapk14 Tec Cltc Jak3 Jun Eif4ebp1 Fyn Rps6 Mitf Socs5 Socs4 Matk Socs6 BCR%NETPATH%BCR BCR Nedd9 Stat1 Foxo3 Hck Fos Prkcb Rps6ka1 Gsk3b Crk Pik3r2 Rela Dok1 Bcar1 Cdk2 Cd72 Stap1 Shc1 Elk1 Sla2 Ctnnb1 Chst15 Bank1 Rb1 Nfatc3 Cd22 Malt1 Cycs Plekha1 Hcls1 Prkcq Gtf2i Lat2 Rasgrp3 Prkd1 Blnk Btk Creb1 Pip4k2b Crkl Pip4k2c Itpr1 Zap70 Pip4k2a Akt1 Cd79b Plcg1 Ptpn18 Ccl4 Pik3cg Ptk2 Atf2 Casp7 Mapkapk2 Nck1 Prkcd Casp9 Mapk1 Nfatc2 Sh2b2 Ifitm1 Fcgr2b Cdk7 Bcl6 Btla Rasa1 Bax Lck Stat3 Pip5k1c Hnrnpk Sos1 Pip5k1b Rps6kb1 Itpr2 Bcl10 Ptpn6 Lyn Mapk14 Grb2 Ikbkb Itk Sh3bp2 Tec Chuk Jun Eif4ebp1 Vav1 Fyn Rps6 Map4k1 Gsk3a Junb Pdpk1 TNFALPHA%NETPATH%TNFALPHA TNFalpha Ccnt1 Cyba Diablo Stat1 Rel Tab2 Mapk8 Traf7 Traf4 Mcm7 Map3k8 Pfdn2 Traf6 Faf1 Birc3 Birc2 Ikbkg Csnk2a1 Tnfrsf8 Ywhah Ywhag Mark2 Psmd12 Hsp90ab1 Tnfrsf1b Akt2 Hdac2 Smarcb1 Dok1 Ywhab Psmd13 Alpl Rasal2 Akap8 Psmb5 Rpl8l1 Ppp6c Gab1 Bcl2l1 Rack1 Fkbp5 Rps6ka5 Smarca4 Fadd Mcm5 Ywhae Smpd3 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Creb1 Map2k5 Itch Hdac1 Zfand5 Akt1 Cflar Hspb1 Bid Ddx3x Trpc4ap Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Mapk1 Casp3 Romo1 Elp1 Psmd1 Casp2 Mapk3 Trim32 Ube2i Spag9 Usp11 Glb1 Skp1 Smarcc2 Pdk1 Sos1 Prc1 Ywhaz Smarcc1 Rnf25 Pkn1 Src Lrpprc Map3k11 Ube2d3 Mtif2 Ube2d2 Btrc Ptpn11 Mapk14 Trap1 Irs1 Jun Cav1 Egfr Cul1 Junb Foxo1 Prkca Stat5a Map2k6 Rb1 Gtf2i Casp7 Mapkapk2 Bax Rpl4 Mapk9 Nkiras1 Brinp1 Nr2c2 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tnf Hsp90aa1 Fbl Ppp1r12a Nfkbia Rpl30 Crebbp Unc5cl Tbk1 Dpf2 Tax1bp1 Grb2 Kcnq1 Polr1b Polr1c Txnip Polr1a Usp2 Xiap Polr1e Fbxw11 Tank Nfkb1 Map3k3 Actl6a Map3k2 Rxra Smarce1 Polr2sl1 Tifa Flna Cdc37 Rffl Inpp5e Rasa3 Nfkbiz Papola Txn Glg1 Bag4 Ripk3 Cradd G3bp2 Dcaf7 Pak1 Cops3 Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Kpna2 Cdk9 Zbtb17 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Fos Prkca Ywhah Pik3r2 Mtor Yes1 Ywhab Shc1 Gab1 Ywhae Ar Akt1 Pik3r1 Pik3cg Ptk2 Prkcd Mapk1 Casp3 Mapk3 Ywhaz Src Clca1 Irs2 Rpsa Rhoa Rac1 Plec Dsp Lama5 Cd151 Itgb4 Lama3 Mst1r Ptpn11 Mylk3 Met Mapk14 Grb2 Pik3r3 Col17a1 Itga6 Ntn1 Ephb2 Lamb2 Lamb3 Sfn Lamb1 Pik3cb Pik3cd Erbb2 Rtkn Irs1 Tp73 Bad Jun Smad2 Eif4ebp1 Smad3 Eif6 Lamc1 Vim Fyn Egfr Eif4e Pak1 WNT%NETPATH%WNT Wnt Csnk1a1 Nlk Lrp5 Gpc3 Dvl3 Mapk8 Wnt2 Wnt1 Tcf7l2 Prkcb Wnt3 Fzd1 Jup Fzd5 Prkca Fzd4 Fzd6 Kremen1 Fzd9 Smad1 Pin1 Mark2 Tcf4 Yes1 Ywhab Prkaca Arrb2 Akt1 Prkcd Nfatc2 Pip5k1b Rhoa Rac1 Jun Ccnd1 Map3k7 Ctbp1 Wnt5a Cdh1 Pi4k2a Ppp1ca Sfrp2 Ppp2ca Sfrp1 Daam1 Cdk6 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Lrp1 Arhgef4 IL6%NETPATH%IL6 IL6 Foxo4 Nlk Stat1 Foxo3 Mapk8 Foxo1 Fgr Hck Fos Gsk3b Pik3r2 Map2k2 Socs3 Map3k4 Pias3 Cd40 Sgk1 Il6st Stat5a Map2k6 Il6 Stat5b Il6r Bmx Ncoa1 Map2k4 Shc1 Gab1 Rb1 Btk Ar Hdac1 Akt1 Plcg1 Hspb1 Pik3r1 Prkcd Mapk1 Mapk3 Stat3 Rps6kb1 Lyn Erbb3 Cbl Rac1 Hsp90aa1 Crebbp Ptpn11 Mapk14 Grb2 Ptk2b Nfkb1 Erbb2 Bad Jun Eif4ebp1 Gab2 Map3k7 Vav1 Fyn Jak1 Eif4e Daxx Cdk9 Map2k1 TSH%NETPATH%TSH TSH Gna13 Tshr Hspa5 Canx Gnai2 Gnai1 Atp1a1 Map2k3 Calr Scrib Gnai3 Gnaq Creb1 Lep Ikbkb Map2k6 Igf1r Raf1 Gna12 Gna11 Mapk3 Gnao1 EGFR1%NETPATH%EGFR1 EGFR1 Map2k2 Ywhab Gab1 Rps6ka5 Dyrk1a Creb1 Itch Hdac1 Pik3r1 Ptk2 Mapk1 Myc Tp53 Irs2 Rhoa Rac1 Plec Dsp Jund Itgb4 Met Pik3r3 Dab2 Col17a1 Ephb2 Sp1 Pik3cb Pik3cd Bad Jun Smad2 Smad3 Cav1 Vim Ctbp1 Cdh1 Stk11 Prkcg Arhgef4 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Jup Gsk3b Crk Pik3r2 Socs3 Map3k4 Pias3 Ap2b1 Map2k3 Scrib App Spart Atf1 Myl12b Pard3 Il17rd Prkd1 Mprip Nedd4 Eno1 Crkl Nectin1 Rps10 Elk4 Plcg1 Gja1 Cblb Tfg Plcg2 Tns4 Scamp3 Tns2 Prkcd Tns1 Itsn2 Ralb Krt8 Otud6b Vasp Cblc Arhgef7 Araf Krt7 Frs2 Frs3 Phlpp1 Actb Actr2 Rps6kb1 Actr3 Pttg1ip Arhgap5 Prkci Arap1 Zdhhc5 Tln1 Lyn Rin1 Pfn1 S100a10 Snca Tfrc Arhgef5 Pik3c2b Hnrnpr Sdc4 Sdc3 Insr Pitpna Kirrel1 Stam Flot1 Atp5f1c Errfi1 Usp6nl Myo6 Slc5a5 Snx5 Tollip Smu1 Dyrk1b Etl4 Cltc Sdc1 Antxr1 Nfkb1 Hip1 Arf4 Braf Adam17 Ptprr Clta Dcbld2 Ptprf Git1 Vav1 Laptm4a Vav2 Cdv3 Plekha6 Cyld Anks1a Mink1 Rplp0 Actn1 Snx33 Actn4 Tkt Baiap2l1 Pak1 Plscr1 Gprc5a Caskin2 Rbck1 Htt Aldoa Git2 Map2k7 Appl2 Stx4 Mpzl1 Rps2 Map2k1 Limd1 Cstb Nedd9 Inppl1 Krt18 Pygb Gsn Mapk8 Pdzd11 Krt17 Ap2s1 Mcf2 Racgap1 Eps15l1 Esyt1 Sdcbp Eppk1 Cttn Axl Ctnnd1 Ensa Stat2 Pkn2 Frk Hipk2 Rela Tjp2 Map3k14 Dok1 Hipk3 Eef1a2 Grb14 Flnb Rictor Grb10 Raf1 Stip1 Cdh2 Plekhn1 Cavin1 Cavin2 Tom1 Cc2d1a Prp4k Cfl1 Prkx Magi1 Hat1 Ap2a1 Pkp2 Ptpra Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Cdk1 Vcl Cysrt1 Stambp Pld1 Map4k5 Lpp Ddx3x Rab5a Pld2 Acp1 Ppp1r14b Itga3 Nck1 Pdgfrb Elmo2 Abl2 Slc38a2 Adam9 Dynll1 Tom1l2 Efnb2 Pkm Ptpre Lck Cav2 Tnk2 Ripk1 Sirpa Ywhaz Ralgds Dlg3 Atp1a1 Alb Bcl2 Crim1 Ptpn6 Ddx6 Pdlim1 S100a11l1 Sh3bgrl Cebpb Afap1l2 Rbm3 Tgif1 Sfpq Nck2 Dapp1 Asap1 Slc12a7 Mt-co2 Ptpn12 Baiap2 Mapk14 Sh3gl3 Arhgap35 Lsr Epha1 Ptk2b Epha2 Epn2 Epn1 Khdrbs1 Dyrk4 Epha4 Rps6ka3 Itgb1 Epn3 Erbb2 Dyrk3 Usp31 Elf3 Eif4ebp1 Klf11 Aplp2 Prkaa1 Dsg2 Prkaa2 Ctnnal1 Cd59b Tnip1 Wbp2 Fyn Jak1 Mvp Trim29 Nos3 Eif4g1 Dock1 Egfr Ephb1 Cebpa Gsk3a Ephb3 Cdk5 Phldb2 Ptpn1 Slitrk6 Rgs16 Rps6ka2 Csk Kras Mta2 Arhgap32 Snrpd2 Egf Tagln2 Spry2 Rbbp7 Spry1 Pten Jak2 Reps2 Sh3kbp1 Ralbp1 Bcar3 Spry4 Pebp1 Ptpn23 Rps6ka1 Slc25a5 Kit Hspe1 Arhgap42 Prkca Zpr1 Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Ptpn18 Pik3cg Casp9 Mapk9 Erbb3 Rpl30 Map3k3 ID%NETPATH%ID ID Rb1 Smad3 Tcf7l2 Rbl2 Psmd4 Fhl2 Rbl1 Id3 Atf3 Map2k2 Hes1 Tcf3 Elk4 Myf5 Mapk1 Cdk2 Raf1 Mapk3 Elk1 Map2k1 IL9%NETPATH%IL9 IL9 Kat5 Stat6 Il9r Stat5a Stat5b Mapk1 Mapk3 IL3%NETPATH%IL3 IL3 Csf2rb Ywhaz Foxo1 Prkcb Ptpn6 Lyn Gsk3b Prkca Crk Pik3r2 Socs3 Socs2 Ywhab Dok1 Bcl2l11 Kcnip3 Rara Fes Slc2a1 Gata2 Hras Inpp5d Shc1 Gab1 Bcl2l1 Prkaca Nfkb1 Rack1 Pik3cd Bad Ptprc Rxra Gab2 Atf1 Creb1 Crkl Ppp2ca Gsk3a Pik3r1 Ptk2 Mapk1 Map2k1 IL5%NETPATH%IL5 IL5 Stat3 Unc119 Stat1 Foxo3 Sos1 Ywhaz Hck Rps6ka1 Lyn Gsk3b Cbl Sdcbp Map2k2 Nfkbia Ptpn11 Mapk14 Grb2 Stat5a Stat5b Ptk2b Raf1 Hras Alox5 Shc1 Pla2g4a Elk1 Il5 Sox4 Ctnnb1 Nfkb1 Rack1 Il5ra Jun Syk Hcls1 Jak1 Crkl Gsk3a Pik3cg Atf2 Prkcd Dnm2 Bax IL4%NETPATH%IL4 IL4 Stat3 Jak2 Rps6kb1 Mapk8 Ptpn6 Irs2 Cbl Cebpb Nfkbia Crebbp Stam Ptpn11 Cd40 Mapk14 Ikbkb Inpp5d Shc1 Elk1 Chuk Nfkb1 Mapk11 Spi1 Pik3cd Il13 Il4 Bad Grk3 Cxcr4 Syk Il13ra1 Snd1 Il2rg Jak1 Cebpa Akt1 Plcg2 Ptk2 Atf2 Prkcd Mapk1 Ets1 Mapk3 Rasa1 IL-7%NETPATH%IL-7 IL-7 Stat3 Stat1 Jak3 Foxo3 Bad Irs1 Foxo1 Il2rg Il7 Irs2 Gsk3b Fyn Map2k2 Akt1 Gsk3a Cblb Pik3r1 Stam Stat5a Mapk1 Stat5b Shc1 Mapk3 Map2k1 NOTCH%NETPATH%NOTCH Notch Stat3 Skp1 Jak2 Src Rbx1 Gsk3b Smad1 Hes1 Tcf3 Hdac2 Rela Nfkb1 Smad3 App Ncstn Aph1b Fhl1 Dll3 Dll4 Maml1 Ring1 Maml2 Akt1 Mfng Furin Pik3r1 Ccn3 Skp2 Jag2 Cul1 Hes6 Mapk1 Maml3 Cirsr Yy1 Psenen Lef1 Notch2 Mapk3 Lfng Psen2 IL2%NETPATH%IL2 IL2 Foxo3 Mapk8 Crk Pik3r2 Mtor Map2k2 Socs3 Rela Sgk1 Stat5a Stat5b Cdk2 Raf1 Shc1 Elk1 Il2rg Creb1 Crkl Akt1 Pik3r1 Pik3cg Atf2 Ccne1 Mapk1 Stam2 Ets1 Mapk3 Il15 Lck Stat4 Il2ra Ybx1 Sos1 Ets2 Plcb1 Tert Nr3c1 Itm2b Bcl2 Ptpn6 Eif3b Il2 Lyn Irs2 Prkcz Cbl Nmi Vil1 Mknk1 Hsp90aa1 Stam Ptpn11 Mapk14 Grb2 Pik3r3 Ptk2b Nfkb1 Pik3cb Jak3 Pik3cd Irs1 Jun Eif4ebp1 Gab2 Vav1 Fyn Jak1 Rps6 Eif4e Map2k1 TSLP%NETPATH%TSLP TSLP Stat3 Stat4 Nfkb1 Stat1 Mapk8 Mapk9 Nfkb2 Nfkbia Eif4e Akt1 Stat6 Rela Mapk14 Stat5a Mapk1 Stat5b Mapk3 Map2k1 RANKL%NETPATH%RANKL RANKL Nfkb1 Spi1 Rel Tab2 Mapk8 Traf6 Map3k7 Nfkb2 Traf3 Tnfsf11 Atp6v1e1 Sqstm1 Tnfrsf11b Ptk2 Trem2 Traf2 Mapk14 Mitf Chuk IL1%NETPATH%IL1 IL1 Rel Tab2 Mapk8 Mapk9 Traf6 Pik3r2 Nfkbia Rela Peli1 Mapk14 Dok1 Map3k14 Ube2v1 Ikbkb Map2k6 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Pla2g4a Ppp6c Myd88 Sod1 Chuk Il1a Nfkb1 Fbxw5 Rb1 Il1b Peli2 Map3k2 Il1r2 Jun Il1r1 Map2k3 Il1rn Akt1 Pik3r1 Atf2 Mapk1 Elp1 Mapk3 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Tkt Hk2 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Galt Aldob Aldoc Aldoa Khk Hk2 Gale P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Atf1 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Mapk11 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Rac2 Akt1 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Nos3 Il10 Ikbkb Spi1 Cxcr1 Stat6 Il15 Irs1 Cxcr2 Stat4 Il13 Il18 Il2ra Irs2 Sla2 Mapk6 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il20ra Il23a Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos1 Il6st Shc1 Il10rb Il3ra Mtor Il2 Il4 Il6 Il5 Il7 Il9 Il6r Il21 Il12rb2 Il11ra1 Il4r Mapk15 Spic Srf Il1a Stat5a Elk1 Stat5b Stat3 Stat2 Stat1 Chuk Cdkn1a Cdkn1b Mapkapk2 Mknk2 Mknk1 Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Qars1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per2 Per1 Per3 Cry1 Cry2 Clock Csnk1d Csnk1e Bmal1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Mvd Fdft1 Lss Fdps Sqle Hmgcs1 Pmvk Ggps1 Hmgcr IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Stx11 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Mapk12 Cdkn1a Mapk13 Mapk14 Hras Mapk11 Pdpk1 Akt3 Ccne1 Pik3c3 Akt2 Ccng1 Ctnnb1 Akt1 Kras Tp53 Tp73 Ppp2cb Rb1 Ppp2ca Pten Pik3c2g Rbl1 Siah1 Nras Cdk2 Pik3r5 Atm Tp63 Atr Pik3r1 Pik3r2 Pik3r3 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcd1 Plcb2 Plcd4 Plcb1 Hrh1 Gng3 Gng5 Plcl1 Prkcz Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Plcg1 Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Gng10 Gna14 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Grin2c Grin2b Grin2a Prkaca Gnaq Grin1 Itpr1 Prkar1b Prkcb Prkx Prkacb Grina Grik5 Grm1 Grm5 Plcb4 Grik1 Gna11 Grin2d OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Txn Pla2g4a Map2k3 Bcl2 Myc Elk1 Map2k6 Stat1 Mapk12 Mapk13 Mapk14 Eef2k Map2k4 Mef2c Mknk2 Mknk1 Mapk9 Jun Mapk8 Mapk11 Max Ddit3 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkx Prkacb Kcnk3 Gnao1 Adcy2 Adcy7 Prkar2a Prkar2b Prkaca Htr1d Kcnk9 Htr1f Gnai2 Htr1b Htr1a Gng11 Gnai3 Gnb1 Gnai1 Gng10 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Prkcz Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Plcg1 Oxtr Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Gng10 Gna14 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Adcy2 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb1 Htr4 Gnb4 Gnal Gnb3 Gnb5 Gng10 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Prkar1b Prkacb Cacna1g Gnao1 Adcy2 Adcy7 Prkar2a Prkar2b Prkaca Gng11 Gnai3 Gnb1 Gnai1 Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy8 Adcy5 Adcy6 Kcnj3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2d2 Uba3 Ube2d1 Ube2e2 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2s Ube2v2 Ube2k Uba6 Ube2d2b ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb3 Nectin1 Trpc6 Afdn Trpc5 Trpc7 Kat5 Wnt5a Trpc1 Cdh1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Bace2 Bace1 Wnt10b Acta1 Actb Actr2 Ern1 Ctnnb1 Psenen Notch1 Notch2 Notch3 Psen1 Gsk3b Psen2 Wnt8a Fstl1 Lef1 Wnt11 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp3 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Cd44 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Jup Fzd5 Trim3 Fzd4 Fzd6 Fzd9 Fzd8 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh7a1 Aldh9a1 Aldh1l2 Aldh1b1 Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 Aldh8a1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Tp63 Tp53 Tp73 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss3 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank4 Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Fos Sos1 Chuk Mapk12 Mapk13 Mapk14 Itpr3 Itpr2 Itpr1 Mapk9 Jun Mapk8 Mapk11 Mapk1 Mapk3 Rac2 Rac1 Nfkbil1 Cd22 Araf Vav3 Syk Plcg2 Vav1 Vav2 Map3k3 Map3k2 Nras Prkcb Blnk Btk Cd79b Prkcd Ptpn6 Lyn Ptprc Ppp3ca Raf1 Ppp3cb Nfkbia Grb2 Mapk10 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Eif4ebp1 Tsc2 Tsc1 Igbp1 Prkaa1 Akt3 Prkab2 Rps6kb1 Akt2 Prkaa2 Prkab1 Prkag1 Akt1 Tp53 Tp73 Ppp2cb Ppp2ca Tp63 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb2 Plcb1 Dagla Lpl Plcb3 Pla1a MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Pmm1 Mpi Gmppa Pmm2 Gmds MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Txn Hif1a Akt3 Akt2 Akt1 Rorc Arnt Mtor Txn2 Crebbp Egln2 Egln3 Vhl THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Taf7 Taf6 Gtf2e1 Taf2 Prkar1b Crebbp Gtf2a1l Polr2c Taf1c Taf9 Creb3l3 Creb3l4 Prkar2a Polr2h Prkar2b Polr2e Creb3l1 Ttf2 Creb3l2 Polr2f Taf9b Taf11 Gtf2h1 Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Tbp Brf1 Tbpl2 Tbpl1 Creb5 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Polr2sl1 Taf8 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gnao1 Adcy2 Oprd1 Adcy7 Gng3 Pomc Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Gnb5 Gng10 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkcz Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Ednrb Ednra Adcy3 Edn1 Edn2 Itpr3 Edn3 Itpr2 Adcy10 Itpr1 Prkar1b Gucy1b1 Prkg2 Prkacb Gucy1a1 Gucy1a2 Mapk1 Pla2g4a Adcy2 Adcy7 Prkar2a Prkar2b Mapk3 Prkaca Akt1 Araf Prkcq Gnal Prkcg Prkch Prkci Adcy4 Prkcb Adcy8 Adcy5 Adcy6 Prkcd Prkce Prkca Raf1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Gch1 Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Prkcz Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Htr2a Htr2c Htr2b Gng11 Plcg1 Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Gng10 Gna14 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Itga2 Itga10 Col4a3 Pxn Arpc3 Col4a1 Cav1 Pik3cg Arpc2 Col4a2 Pik3cb Col8a1 Pik3cd Col4a5 Arpc5 Parvb Pik3c2b Parva Pik3c2a Rap2b Ptk2 Col16a1 Arf1 Map2k2 Col12a1 Itgax Map2k1 Ilk Hras Itgav Rnd2 Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Itgal Arhgap10 Rap1a Col3a1 Rap1b Itgad Mapk6 Itgb8 Itgb6 Itgb7 Itgb1 Itga2b Actb Itgb4 Rras Itgb2 Actn1 Actn4 Crk Arf6 Arhgap26 Col11a1 Col11a2 Src Dock1 Bcar1 Dnajc27 Sos1 Lamb2 Lamb3 Shc1 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a2 Ptk2b Lims2 Lamc1 Actg1 Actbl2 Flna Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Mapk9 Mapk8 Col14a1 Itgbl1 Crkl Arfgap1 Map2k3 Col1a2 Col5a2 Braf Col5a3 Col5a1 Dmbt1 Pik3c3 Mapk3 Col9a2 Col9a1 Arpc1b Rac2 Lama5 Arpc1a Rac1 Lama1 Lama3 Araf Lama4 Flnb Tln1 Vcl Vasp Col17a1 Nras Col13a1 Itga7 Fn1 Itga8 Arl1 Itga5 Itga6 Itga9 Raf1 Itga3 Elmo2 Pik3r1 Itga1 Pik3r2 Elmo1 Pik3r3 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Stat6 Stat4 Arhgap10 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Arhgap26 Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Ehf Srgap1 Srgap3 Rab11b Arhgap5 Arhgap4 Mapk15 Erf Erg Arhgap9 Stat5a Shc3 Stat5b Rasa2 Stat3 Rasa1 Stat2 Pdgfrb Stat1 Pdgfra Chuk Pdgfa Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Vav3 Vav1 Vav2 Map3k2 Grb2 Mapk10 Rps6kb1 Pik3r5 Srf Elk1 Map3k4 Itpr3 Mapkapk2 Itpr2 Itpr1 Rps6ka5 Mknk2 Mknk1 Jun Mapk8 Mapk1 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Myo5c Myo5b Myo1a Myh11 Myo1g Myo1f Plekhh3 Myh10 Myh7b Myo6 Myo18b Myo5a Myo9a Slc5a7 Chrnd Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Myo15a Myo16 Myo19 Acta1 Actb Actg1 Actg2 Actbl2 Actc1 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 Slc44a3 Actr1a Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh2 Myh3 Myh4 Myh7 Myo1c Myo1b Myo1e Myo1d JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Jak3 Jak2 Stat5a Jak1 Stat5b Stat3 Stat4 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psat1 Phgdh Psph AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Ntn1 Ntn3 Nfatc4 Nfatc3 Nfatc2 Ablim1 Dcc Ntng1 Unc5b Unc5d Unc5c Rac2 Rac1 Plcg1 Plcg2 Vasp Pik3r5 Pik3r1 Pik3r2 Pik3r3 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc18a2 Slc6a19 Slc6a18 Slc6a15 Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc6a3 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt1a2 Ugt1a3 Inmt Ugt1a5 Ugt2b7 Fmo3 Cyp2a3 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a Mat1a Mtr CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myh11 Arpc3 Arpc2 Myh10 Myh7b Arpc5 Acta1 Actb Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Actg1 Pak5 Actg2 Pak4 Tubb5 Tubb6 Tubb3 Actbl2 Mylk Actc1 Limk1 Arpc4 Rock2 Tubb4b Rock1 Rac2 Arpc1b Rac1 Arpc1a Myo3b Myh2 Myh3 Myh4 Myh7 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rps6kb1 Elk1 Rasa1 Map2k2 Map2k1 Ins2 Insr Igf2r Igf2 Igf1 Rps6ka5 Insrr Igf1r Irs1 Irs2 Mapk1 Map2k3 Mapk3 Fos Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Jak2 Jak1 Ifngr2 Ifng Ifngr1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp2 Uprt Nme3 Nme2 Uck1 Uck2 Uckl1 Upp1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Grin2a Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Adcy10 Prkar1b Prkx Prkacb Grm1 Grm5 Prkar2a Prkar2b Cacna1e Prkaca Grm4 Grm7 Gnai2 Grm6 Grm8 Vti1a Gnai3 Slc17a7 Stx1b Gnb1 Cacnb1 Gnai1 Stx1a Cacna1a Cacna1b APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Xiap Endog Rela Map3k1 Apaf1 Tnfrsf10b Lta Pik3cg Fadd Atf7 Pik3cb Ltb Pik3cd Atf6 Casp9 Atf4 Atf3 Jdp2 Aifm1 Map2k7 Gzmf Map4k3 Atf6b Cradd Ikbkb Bak1 Eif2s1 Casp8 Casp7 Prkra Casp3 Bik Ripk1 Map4k2 Diablo Bax Rel Fas Faslg Daxx Map3k14 Akt3 Akt2 Tp53 Fos Atf1 Chuk Igf2r Map2k4 Mapk9 Jun Mapk8 Mapk1 Map2k3 Bcl2 Mapk3 Akt1 Prkcq Atf2 Prkcg Birc3 Prkch Eif2ak2 Birc2 Tnf Prkcb Madd Bcl2l11 Tnfrsf1b Prkcd Tnfrsf1a Tradd Prkce Nfkb2 Prkca Nfkb1 Traf2 Nfkbia Cycs Bcl2l1 Mapk10 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Map3k1 Pik3cg Pik3cb Pik3cd Map2k7 Map2k2 Map2k1 Hras Rhoa Rhob Pdpk1 Tiam1 Akt3 Ralgdsl1 Rala Ralb Exoc2 Pld1 Pld2 Kras Ralgds Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Pak1 Pak3 Pak2 Srf Elk1 Stat3 Map2k6 Map3k4 Stat1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Map2k4 Mapk9 Jun Mapk8 Mapk11 Mapk1 Map2k3 Gsk3a Braf Ets1 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Araf Atf2 Nras Raf1 Grb2 Mapk10 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb2 Plcb1 Gng3 Gng7 Elk1 Gnaq Gng8 Gngt2 Gnb2 Map2k2 Gnb4 Gnb3 Map2k1 Gnb5 Itpr3 Itpr2 Itpr1 Mapk1 Mapk3 Grk3 Gng11 Grk2 Arrb2 Gnb1 Arrb1 Egr1 Agtr1 Agt Prkca Plcb3 Raf1 Gng10 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Taf7 Taf6 Gtf2e1 Taf2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Taf9b Taf11 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Sirt1 Cdc25c Cdkn1a Crebbp Pdpk1 Mdm2 Akt3 Mdm4 Ccne1 Akt2 Akt1 Tp53 Tp73 Pten Gadd45g Sumo2 Cdk2 Chek2 Sumo3 Atm Gadd45b Tp63 Gadd45a Atr Hdac1 Sfn Cdkn2a Mta2 Traf2 Ccnb1 Gtse1 Cdk1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Prkcz Vamp8 Vamp1 Vamp3 Vamp2 Snap29 Snap25 Snap23 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Trh Plcd4 Plcb1 Trhr Stx3 Gng3 Cga Gng5 Cacnb3 Plcl1 Cacnb4 Gng7 Cacnb2 Gnaq Tshb Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Cacna1e Plcg1 Gnb1 Prkcq Cacnb1 Plcg2 Cacna1a Prkcg Cacna1b Prkch Prkci Prkcb Prkcd Prkce Prkca ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b2 Lipa Cyp19a1 Hsd17b7 Hsd17b6 Soat2 Hsd17b3 Soat1 Hsd17b1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10b Acta1 Actb Actr2 Wnt8a Fstl1 Lef1 Wnt11 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Fzd5 Fzd4 Pcdhb2 Fzd6 Pcdhb1 Fzd9 Cdh9 Fzd8 Cdh8 Cdh7 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Cdh2 Pcdh19 Pcdh18 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Ctnnd2 Pcdhga2 Ctnnd1 Pcdhga3 Ctnnb1 UNTITLED%PANTHER PATHWAY%P06664 untitled Rela Tgif1 Skil PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Aco2 Sdhc Pdk2 Cs Fh Pdha2 Suclg1 Mdh1 Ogdh ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Aldh6a1 Dpys Dpyd Dpysl2 Abat Dpysl3 Cda Upb1 Dpysl5 Nt5e ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Adcy2 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Prkaca Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Adrb1 Prkx Prkacb Gng10 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Tsc2 Tsc1 Gsk3a Pdpk1 Mdm2 Mdm4 Foxo3 Gsk3b Pten Ins2 Insr Igf2r Igf2 Foxo1 Igf1 Insrr Igf1r Irs1 Irs2 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Adcy2 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Prkaca Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Prkx Hrh2 Prkacb Gng10 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Adcy2 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Adrb3 Gng10 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Ampd3 Gda Xdh Nt5e METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gng3 Pomc Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Crh Crhr2 Gna11 Crhr1 Gng10 Gna14 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Klc1 Adam17 Mapk4 Klc4 Klc3 Klc2 Mapk15 Apba1 Prkcz Apba2 Cacnb2 Apba3 Pkn1 Mapk12 Mapk13 App Mapk14 Cacna1c Kat5 Mapk9 Mapk8 Mapk11 Mapk1 Mapk6 Bace2 Bace1 Mapk3 Psenen Pkn2 Psen1 Psen2 Cacnb1 Prkcq Prkcg Prkch Ncstn Prkci Aph1b Prkcb Prkcd Prkce Prkca Cacna1f Cacna1d Mapk10 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Dcc Srgap1 Ntng1 Rac2 Cxcl12 Rac1 Slit1 Slit2 Slit3 Robo1 Cxcr4 Abl1 Ntn1 Ntn3 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Dscaml1 Nme3 Dhodh Nme2 Cad Ctps2 Cps1 Ctps1 Nme1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Shc2 Pik3cg Prkcz Pik3cb Pik3cd Pik3c2b Pik3c2a Map2k7 Map2k2 Map2k1 Erbb4 Hras Stat6 Stat4 Akt3 Akt2 Rras Sos1 Pik3r5 Shc1 Stat5a Shc3 Stat5b Rasa2 Stat3 Rasa1 Map2k6 Stat2 Map3k4 Stat1 Mapk12 Mapk13 Grap Mapk14 Map2k4 Erbb2 Erbb3 Mapk9 Mras Rasal2 Gab1 Mapk8 Gab2 Egfr Mapk11 Phldb2 Prkd3 Nf1 Mapk1 Rras2 Dab2ip Map2k3 Prkd1 Spry2 Braf Spry1 Prkd2 Spry4 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Map3k3 Prkci Map3k2 Nras Prkcb Prkcd Prkce Prkca Raf1 Mapk10 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Serpinb2 Fgb Fga Mmp13 Mmp1 Plau Fgg Serpinf2 Plat Plg Serpine1 Mmp9 PNAT%PANTHER PATHWAY%P05912 PNAT Stx3 Gng3 Gng8 Gnb2 Vamp8 Gnb4 Vamp1 Gnb3 Vamp3 Vamp2 Snap29 Prkx Prkacb Snap25 Snap23 Epb41l2 Clic6 Ppp1r1b Kcnk3 Epb41l1 Slc18a2 Adcy2 Drd2 Adcy7 Drd4 Prkar2a Ppp1ca Prkar2b Prkaca Kcnk9 Gnai2 Epb41 Slc6a3 Gng11 Gnai3 Gnb1 Flna Gnai1 Epb41l3 Drd1 Drd5 Ppp1cc Gnaz HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Shh Smo Ptch1 Sufu Crebbp Stk36 Fbxw11 Gli1 Btrc MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Kcnj5 Chrm2 Chrm4 Gnat2 Gnat1 Gng3 Gng5 Gng7 Gng8 Gngt2 Slc5a7 Gnb2 Gnb4 Gnb3 Gnb5 Adcy10 Prkar1b Prkx Prkacb Gnao1 Prkar2a Prkar2b Prkaca Gnai2 Gng11 Gnai3 Gnb1 Gnai1 Slc18a3 Slc6a8 Kcnj3 Gng10 Kcnj9 Kcnj6 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Amdhd2 Gnpda2 Npl Gfpt1 Gfpt2 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Bmp10 Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf1 Jund Acvr1c Snip1 Hras Lefty1 Tgfb2 Tgfb3 Gdnf Skil Cited1 Acvrl1 Cited2 Acvr1b Crebbp Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Gdf3 Gdf6 Bmp7 Bmp6 Bmp5 Gdf7 Bmp4 Rras Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Inhba Inhbb Acvr2b Junb Inhbc Tgfbr1 Smad5 Tgfbr2 Smad6 Inhbe Smad7 Gdf11 Gdf10 Map3k7 Mapk12 Mapk13 Mapk14 Mapk9 Jun Mapk8 Mapk11 Mapk1 Mapk3 Atf2 Nras Mapk10 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F2r Kng2l1 Klkb1 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz Tfpi F2 Serpina10 F3 Thbd F7 F8 F9 Pros1 Fgb Itga2b Fga Plau Fgg Plat Plg PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Gnat2 Rps6kb1 Pik3cb Gnaq Casp9 Gngt2 Nos3 Gnb2 Gnb4 Gnb3 Gnb5 Insr Irs1 Ptger1 Foxo4 Gngt1 Ywhaz Pdpk1 Akt3 Akt2 Foxo3 Gnai2 Akt1 Gnai3 Gsk3b Gnb1 Gnai1 Nras Sos1 Foxo1 Pik3r5 Gna11 Pik3r1 Pik3r2 Gna14 Pik3r3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Kcnj5 Chrm2 Chrm4 Rap1a Rap1b Gsk3b Gngt1 Adora2b Adora2a Adra2c Adra2b Htr6 Htr7 Gsk3a Oprl1 Adcy2 Phka1 Drd2 Phka2 Drd4 Adrb2 Adra1b Prkaca Adra1a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Gnb1 Oprm1 Htr5a Gnai1 Phkb Chrm1 Chrm3 Chrm5 Hrh4 Hrh3 Adora1 Gnrhr Gys1 Gys2 Clta Cltb Cltc Mtnr1a Creb1 Creb3 Phkg1 Phkg2 Mtnr1b Pygb Pygl Grm2 Gpr50 Oprk1 Crebbp Creb3l3 Creb3l4 Creb3l1 Creb3l2 Adrb1 Hrh2 Adrb3 Creb5 Gng10 Oprd1 Hrh1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Adcy3 Prkar1b Prkacb Grm1 Grm5 Htr2a Htr2c Htr2b Adcy7 Prkar2a Prkar2b Htr1d Grm4 Htr1f Grm7 Gnai2 Grm6 Htr1b Grm8 Htr1a Gnai3 Htr4 Gnal Drd1 Drd5 Adcy4 Adcy8 Adcy5 Adcy6 Kcnj3 Kcnj9 Kcnj6 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Pik3cg Prkcz Map3k6 Pik3cb Frs2 Pik3cd Frs3 Fgfr3 Pik3c2b Fgfr4 Pik3c2a Fgfr1 Fgfr2 Map2k7 Map2k2 Map2k1 Hras Akt3 Akt2 Sos1 Shc1 Shc3 Rasa2 Rasa1 Map2k6 Map3k4 Mapk12 Mapk13 Grap Mapk14 Map2k4 Mapk9 Mapk8 Mapk11 Mapk1 Map2k3 Spry2 Spry1 Spry4 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Map3k3 Prkci Map3k2 Nras Prkcb Prkcd Ptpn6 Prkce Prkca Raf1 Mapk10 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Ass1 Otc Cad Cps1 Asl HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnat1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb5 Cnga3 Pdc Cnga1 Grk1 Rho Calml3 Rgs9 Cngb1 Pde6a Gngt1 Pde6b Cngb3 Rcvrn Gng13 Gnb1 Gng10 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Mapk15 Elk1 Mapk12 Mapk14 Mapk9 Ywhaz Mapk8 Psma4 Psma3 Mapk1 Psma6 Psma5 Ccne2 Psma2 Psma1 Ccne1 Cask Ywhah Mapk3 Ywhag Ywhae Pld2 Th Ywhab Psmb10 Slc6a3 Sncaip Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Psmb3 Stx7 Septin2 Septin1 Gpr37 Stx12 Ndufv2 Sfn Snca Mapk10 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Grin2a Gng3 Gng5 Prkcz Gng7 Gnaq Pkn1 Gng8 Grin1 Gngt2 Slc5a7 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Grin2d Grin2c Grin2b Pkn2 Gng11 Gnb1 Prkcq Prkcg Chrm1 Prkch Chrm3 Prkci Slc18a3 Prkcb Prkcd Prkce Plcb4 Prkca Gna11 Gng10 Gna14 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Adcy2 Oprd1 Adcy7 Gng3 Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Gnb5 Pdyn Penk Gng10 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc3 Rfc4 Pcna Rfc1 H3f3b Rfc2 Rpa2 Top1 Dna2 Rfc5 Pold2 Pold1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Pccb DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Nme3 Nme2 Adsl Rrm2 Impdh2 Rrm2b Gmps Ak3 Ak2 Ak4 Adss2 Dscaml1 Atic Nme7 Ppat Nme6 Guk1 Gart Nme1 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra Vdr F13b Rara Gc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Chrm2 Chrm4 Grm2 Prkcz Oprk1 Rhoa Rap1a Gng13 Rap1b Dnajc27 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Oprd1 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Itpr3 Itpr2 Itpr1 Grm1 Grm5 Gngt1 Rap1gap Adora2b Rasgrp3 Adora2a Rasgrp4 Rasgrp1 Rasgrp2 Arhgef1 Bdkrb2 Oprl1 Gnao1 Bdkrb1 Gpr45 Drd2 Drd4 Cacna1e Grm4 Grm7 Grm6 Sstr5 Grm8 Sstr4 Sstr3 Sstr2 Sstr1 Gnb1 Prkcq Oprm1 Cacna1a Prkcg Cacna1b Prkch Chrm1 Drd1 Prkci Chrm3 Drd5 Chrm5 Prkcb Adora1 Gnrhr Prkcd Prkce Clta Prkca Cltb Cltc ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Lpxn Arhgap8 Shc2 Map3k1 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Rhoa Rhob Wnt5a Wnt5b Akt3 Wnt10b Akt2 Pld1 Pld2 Notch1 Fos Notch2 Crk Gsk3b Src Sos1 Shc1 Rbpjl Wnt7b Dvl1 Dvl3 Wnt7a F2r Wnt2 Wnt1 Tcf7l2 Stat3 Rasa1 Fzd1 Pdgfrb Stat1 Pdgfra Pdgfa Fzd2 Pdgfb Fzd5 Grap Nck2 Jak1 Nck1 Frs2 Frs3 Fgfr1 Ctnnb1 Pak1 Pak3 Pak2 Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Jun Mapk8 Prr5 Prkd3 Mapk1 Crkl Pla2g4a Prkd1 Braf Prkd2 Grb14 Ets1 Fgf1 Pik3c3 Mapk3 Dok1 Dok3 Cryab Axin1 Akt1 Grb7 Pdgfc Sh2d2a Tcf7 Plcg1 Efnb1 Araf Jag2 Prkcq Efnb2 Plcg2 Jag1 Prkcg Pla2g4d Prkch Angpt1 Prkci Apc2 Nras Epha3 Prkcb Ephb1 Sphk2 Ephb2 Arhgap1 Dll1 Prkcd Ephb3 Sphk1 Dll3 Prkce Dll4 Prkca Dlk1 Raf1 Apc Pik3r1 Pik3r2 Pik3r3 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Dscaml1 Nme3 Nme2 Nme1 Rrm2 Tyms Rrm2b SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt1 Syt11 Syt12 Syt7 Syt6 Unc13c Rab3a Stxbp1 Unc13b Syt15 Stx2 Unc13d Stx1b Vamp1 Stx1a Snap25 Syt5 Syt3 Syt2 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Pxn Pik3cb Nr2c2 Clu Ier3 Ptk2 Rps6 Map2k2 Sp1 Sp3 Map2k1 Elavl1 Akt1s1 Itgav Yes1 Snai1 Tcf4 Rhoa Hbegf Nos1 Irs1 Hdac7 Casp3 Akap1 Cckbr Cdh1 Pparg Gucy2e Arhgef28 Bax Cd38 Ptgs2 Camk4 Elk4 Map2k5 Pdpk1 Ptpn11 Map3k14 Itgb1 Tpcn1 Bad Cck Gast Foxo3 Map3k11 Fos Crk Gsk3b Arrb2 Rps6ka3 Egr1 Src Rps6ka1 Bcar1 Sos1 Shc1 Ptk2b Stat3 Jak2 Slc18a2 Prkaca Gnb1 Lyn Ppp3ca Nfkbia Grb2 Creb1 Mapk10 Eif4ebp1 Rps6kb1 Nfatc2 Odc1 Ctnnb1 Ywhab Foxo1 Pak1 Traf6 Srf Mef2d Elk1 Map2k6 Hspb1 Mapk14 Rock1 Itpr1 Eif4e Map2k4 Prkacb Mef2c Mapk9 Jun Mapk8 Mapk1 Pla2g4a Prkd1 Bcl2 Braf Prkd2 Mapk3 Plau Akt1 Rac1 Plcg1 Araf Prkcq Atf2 Prkch Prkcb Prkcd Prkce Prkca Raf1 Pik3r1 Bcl2l1 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Aldoa Pklr Eno1 Bpgm Eno2 Pfkl Pkm Pgk1 Pgam2 Tpi1l2 Pfkm Gpi Hk2 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Jag1 Maml1 Numb Cirsr Dll3 Dll4 Notch1 Notch2 Dlk1 Rbpjl Notch3 Jag2 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Gad2 Abat FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Gsn Casp6 Capg Scin Apaf1 Dffb Fadd Casp9 Map2k4 Casp8 Casp7 Casp3 Mapk9 Jun Mapk8 Fas Faslg Daxx Faf1 Parp3 Parp2 Parp1 Cflar Lmnb1 Lmnb2 Mapk10 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Rela Arpc3 Pik3cg Arpc2 Prkcz Pik3cb Pik3cd Arpc5 Jund Col12a1 Ikbkb Cxcr1 Rhoa Cxcr2 Itgal Pdpk1 Itgb7 Akt3 Itgb1 Acta1 Akt2 Actb Rras Sos1 Shc1 Junb Il2 Col6a2 Ptk2b Cxcr3 Cxcr5 Cxcl10 Actg1 Fpr1 Actg2 Fpr3 Ccr10 Stat3 Ccr1 Xcr1 Vwf Actbl2 Ccrl2 Actc1 Chuk Ltb4r2 Rhog Ccr9 Grap Ccr8 Ccr7 Ccr6 Ccr5 Ccr4 Ccr3 Jak2 Ccr2 Cx3cr1 Ifnar1 Camk2d Ccl11 Ccl12 Ccl7 Camk2a Ccl5 Ccl4 Ccl3 Ccl2 Adcy2 Pf4 Prex1 Cx3cl1 Nfat5 Prkaca Ccl22 Ccl20 Ccl21 Gnai1 Myo3b Vav1 Myh2 Myh3 Myh4 Myh7 Myh11 Myh10 Myh7b Nfatc4 Nfatc3 Nfatc2 Cask Kras Plcb4 Mylk2 Plcb3 Gna11 Mylk3 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Pak1 Plcb1 Pak6 Gng3 Pak3 Gng5 Pak2 Plcl1 Pak5 Gng7 Pak4 Gnaq Gng8 Plcz1 Mylk Plce1 Arpc4 Cxcr4 Gnb3 Rock1 Itpr3 Itpr2 Itpr1 Prkx Prkacb Ifng Jun Col14a1 Mapk1 Gnao1 Mapk3 Arpc1b Rac2 Gnai2 Akt1 Arpc1a Rac1 Plcg1 Gnai3 Araf Plcg2 Nras Prkcb Adcy5 Adcy6 Prkce Nfkb2 Raf1 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Gda Prtfdc1 Pnp Hprt1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Dync1li1 Dnai2 Dynll1 Grin2a Dynll2 Apaf1 Capn9 Cyc1 Capn5 Capn7 Capn6 Capn1 Grin1 Capn3 Arpc5 Capn2 Dlg4 Dnah5 Dnah8 Map2k7 Cyfip1 Sp1 Capns1 Capn11 Capn12 Casp8 Grik5 Casp3 Crebbp Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Acta1 Actb Actr2 Tp53 Fos Tp73 Tbp Tp63 Tubb2b Tubb2a Actg1 Actg2 Tubb5 Tubb6 Tubb3 Actbl2 Actc1 Rhog Tubb4b Map2k4 Mapk9 Map3k10 Jun Rac2 Arpc1b Rac1 Arpc1a Hip1 Bdnf Ift57 Dync1h1 Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Ap2a1 Hap1 Hip1r Kalrn Cltb Htt Gapdhs Dync1li2 Dync2h1 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Acly Pc Me1 Clybl Pck1 Pklr Cs Pdha2 Pkm T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Map3k1 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Zap70 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3d Ppp3cc Lat Akt3 Akt2 Fos Sos1 Pak1 Pak3 Pak2 Chuk Itpr1 Nck2 Nck1 Mapk9 Jun Mapk8 Mapk1 Braf Pik3c3 Mapk3 Grap2 Akt1 Rac1 Plcg1 Araf Vav3 Prkcq Vav1 Vav2 Nras Ptprc Ppp3ca Raf1 Ppp3cb Pik3r1 Nfkbia Pik3r2 Pik3r3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Traf6 Elk1 Map3k7 Chuk Map2k2 Mapk14 Map2k1 Ikbkb Mapk9 Jun Mapk8 Map2k3 Map3k8 Tbk1 Ticam2 Mapk3 Irak4 Ecsit Nfkbie Tollip Irak1 Tlr10 Myd88 Tank Irf3 Tlr7 Tlr6 Tirap Tlr4 Tlr3 Tlr2 Nfkbia VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10b Arrb2 Wnt8a Arrb1 Fstl1 Lef1 Wnt11 Lrp6 Hdac1 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Pcdhb2 Fzd6 Pcdhb1 Fzd9 Fzd8 Cdh9 Cdh8 Cdh7 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Cdh2 Pcdh19 Pcdh18 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fat2 Fat1 Fat3 Pcdhb22 Pcdhac2 Cdhr2 Ppp3ca Pcdha13 Ppp3cb Cdhr1 Pcdha10 Pcdha11 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Crebbp Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Tle3 Tle2 Tle1 Ctnna2 Ctnna1 Csnk1g3 Hdac3 Hdac2 Csnk1g2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Prkcq Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Fbxw11 Btrc Prkcz Smad1 Gsk3b Smad4 Smad5 Gnb1 Csnk1d Csnk1e Nfatc4 Nfatc3 Gng13 Nfatc2 Ctnnb1 Ppp2cb Ppp2ca Siah1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng5 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Itpr2 Itpr1 Axin1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Ada Prtfdc1 Xdh Pnp Hprt1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gnat2 Gng3 Grm2 Gng5 Gng7 Gng8 Gngt2 Gnb2 Vamp8 Gnb4 Vamp1 Gnb3 Gnb5 Vamp3 Adcy10 Vamp2 Prkar1b Snap29 Prkx Prkacb Snap25 Snap23 Gnao1 Prkar2a Prkar2b Cacna1e Prkaca Gnai2 Gng11 Gnai3 Stx1b Gnb1 Cacnb1 Stx1a Gnai1 Cacna1a Cacna1b Gng10 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnao1 Adcy2 Adcy7 Gng3 Gng5 Oprk1 Gng7 Gnai2 Gng8 Avp Gngt2 Oxt Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Gnb5 Pdyn Gng10 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Arhgef1 Pak1 Rac2 Dpysl2 Nrp1 Rac1 Dpysl4 Plxnb1 Dpysl5 Sema3a Sema4d Cdk5 Dpys Fes Crmp1 Frk Rhoa Fyn ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb2 Gnao1 Plcb1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gng11 Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Cacna1a Cacna1b Cnr1 Cacna1g Grm1 Grm5 Plcb3 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Taf1c Rrn3 Tbp Polr1b Taf1a Tbpl2 Cavin1 Tbpl1 Taf1b Ubtf Taf8 Psmc3ip PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Adcy2 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Adrb2 Prkaca Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Prkx Prkacb Gng10 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Oprd1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkx Prkacb Gnao1 Adcy2 Adcy7 Prkar2a Prkar2b Prkaca Gnai2 Gnai3 Gnb1 Oprm1 Gnal Gnai1 Pdyn Penk Gng10 Creb1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Adra2b Plcb2 Plcb1 Adra1b Adra1a Plce1 Prkcg Itpr1 Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Adra2c LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ren1 Ace Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Acadm Abat Acss1 Bckdhb Echs1 Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Ldhal6b Aldh6a1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkca Prkcb P2ry2 Plcg1 Ptk2b THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Cant1 Galt Slc2a1 Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Dusp1 Cd40lg Nfkb1 Chuk Ikbkb Mapk14 Cd40 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Itpka Plcb4 Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Mtor Isyna1 Vac14 Becn1 Sacm1l Inpp1 Pik3cb Pik3r4 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Fbp1 Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl Taldo1 G6pdx CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ren1 Ace Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Pgm2l1 Gys1 Gaa Agl Pygl Amy1 Ugp2 Pgm1 Ugdh Gpi Gusb LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Grhpr Pklr Mdh1 Aldh2 Glo1 Hagh Acat1 Me1 Acaca Acyp1 Acot12 Pc Pck1 Pdhb Akr1b1 Dlat Dld CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Cyp2b2 Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 D2hgdh GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Ugt8 Gpi Gusb T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Ppp3ca Jun Ppp3cb Syk Fos Nfkbia Rela Map3k1 Nfat5 Map2k1 Nfkb1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca Mapk8 Shc1 Ptpn7 Cd3g Cd247 Elk1 Map2k7 Cd3d Calm2 Mapk3 Ubc Fyn Rac1 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Akr1c18 Abcg2 Ralbp1 Cbr1 Abcc1 Por Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Sds Glud1 Aqp8 Asrgl1 Asns Amt Cps1 Dld Hal Gls2 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Cacna1c Nfkbia Rela Cacna1f Cacna1d Map2k1 Mapk1 Nfkb1 Itpr1 Plcb1 Raf1 Prkcb Hras Prkca Mapk3 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacna2d2 Cacnb1 Ins2 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Pik3cd Pip4k2a Plcb1 Pik3r1 Pikfyve Vac14 Becn1 Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Fbp1 Tkt Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Odc1 Srm Mat2a Amd1 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ren1 Ace Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Aldoa Tpi1l2 Gmppa Pmm1 Mpi Uxs1 Sord Khk Akr1b1 Pfkfb1 Gmds Pfkl ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Dck Nme1 Dctd Tyms Rrm2b Slc28a3 Cmpk1 Rrm2 Slc29a1 Ctps1 Slc28a1 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Nqo1 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Pdia2 Atp1a1 Sdf2l1 Atp1a4 Ugt1a6a Fxyd2 Atp2a2 Hyou1 Comt Pdia6 Atp1a3 Scn5a Pdia4 Kcnd3 Ppib Dnajb11 Kcnj8 Cyp1a2 Snta1 Ugt1a9 Kcnj5 Erp29 Kcnj4 Kcnh2 Ugt1a5 Chrm2 Ugt1a1 Kcnk1 Hspa5 Kcnq1 Ephx1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Cyp2e1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cyp2c11 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Cant1 Galt Slc2a1 Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Cmpk2 Upp2 Dctd Dpyd Uckl1 Itpa Rrm2 Cad Cant1 Nme6 Tymp Tyms Dhodh Rrm2b Cda Upb1 Gda Dpys Ctps1 Ak3 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Acadl Hsd17b10 Echs1 Acads Acss3 Hadh Acaa2 Acat1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Sult1a1 Fmo1 Cyp2b2 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Qars1 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcb1a Ralbp1 Abcc1 Abcc3 Cdkn1a Tp53 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Aldh1a1 Dnajb11 Erp29 Cyp2a3 Ugt1a1 Hspa5 Cyp2b2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Aldh3a2 Slc27a2 Hacl1 Abcd1 Phyh Abcd2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ren1 Ace Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Cmpk2 Upp2 Dctd Dpyd Uckl1 Itpa Rrm2 Cad Cant1 Nme6 Tymp Tyms Dhodh Rrm2b Cda Upb1 Gda Dpys Ctps1 Ak3 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Fah Tat Pah Yars1 Hpd Farsa Farsb Hgd Got1 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency H6pd Prpsap1 Pfkm Rbks Aldob Fbp2 Rpia Gpi Taldo1 Tktl1 Rpe FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Aldoa Pfkm Pklr Eno1 G6pc1 Pgam2 Gpi Galm Hk2 Tpi1l2 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Aldoa Tpi1l2 Gmppa Pmm1 Mpi Uxs1 Sord Khk Akr1b1 Pfkfb1 Gmds Pfkl AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ren1 Ace Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Prkacb Cga Ppp1ca Gnb1 Adcy2 Creb1 Gngt1 Fshr AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Th Ddc GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Gpam Gpd1 Crls1 Ptpmt1 Cds2 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp2b2 Cyp2d4 Ugt1a9 Slc22a1 Ugt2b7 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Ppp3ca Jun Ppp3cb Syk Fos Map3k1 Nfat5 Cd79b Map2k1 Lyn Lck Orai1 Grb2 Blnk Raf1 Hras Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Calm2 Mapk3 Rac1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Gnaq Gnb1 Plcb1 Chrm1 Htr2c Gngt1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Farsa Farsb Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ren1 Ace Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Aldoa Pfkm Pklr Bpgm Eno1 G6pc1 Pgam2 Slc2a2 Gpi Galm Hk2 Pgk1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp2e1 Sult1a1 Cyp2d4 Sult2a1 Abcc4 Abcb1a Abcc5 Abcg2 Gstp1 Ugt2b35 Abcc1 Gstt1 Pdia2 Sdf2l1 Ugt1a6a Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a9 Erp29 Cyp2a3 Ugt1a1 Hspa5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Sds Bckdhb Bckdha Pccb Dbt Dld METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mthfr Dhfr Slc46a1 Mthfd1l Mtfmt Ggh Mthfd1 Mthfd2 Mthfs Ftcd CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cyp2d4 Cbr1 Ugt1a9 Cyp2c11 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcb1a Ralbp1 Abcc1 Abcc3 Cdkn1a Tp53 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Pla2g2a Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Gpd2 Slc25a4 Sdhd Sdhc Slc37a4 Sdhb Sdha Mt-co1 Ndufa1 Mt-atp6 Cycs Uqcrc1 Atp5f1d Atp5f1c Atp5pb Atp5mc2 Atp5f1b Atp5f1a VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Vkorc1 Nqo1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn1b Scn10a Cyp1a2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Arg1 Glud1 Ass1 Got2 Cps1 Gpt Slc25a15 Slc1a5 Slc1a4 Asl Otc Gls2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ren1 Ace Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Galt Gaa Akr1b1 Gale Ugp2 Glb1 G6pc1 Pgm1 Lct B4galt1 Gla FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ipmk Nudt3 Impa1 Ip6k1 Inpp5j Isyna1 Itpka Itpk1 Ippk Inpp4a Inpp4b Bpnt1 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Hmgcl Oxct1 Echs1 Acads Hadh Acat1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Abat Gad1 Gss Cps1 Gclc Gclm Gmps Gls2 Glud1 Nagk Qars1 Cad Gnpnat1 Gfpt1 Got2 Gpt Ppat BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Idi1 Mvd Fdft1 Hmgcs1 Lss Sqle Acat1 Pmvk Hmgcr Fdps BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Pkm Pfkp Gpi Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Fbp1 Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl Taldo1 G6pdx PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Gpd2 Cdipt Pgs1 Cds1 Gpam Pla2g2d Gpd1 Ptdss1 Crls1 Ptpmt1 Ptdss2 Phospho1 Pld2 Plpp1 Pisd Pcyt1a Pla2g15 Lypla1 Chat Dgka Chka Agpat1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8a Cfb Cfd C3 C5 C6 C7 C9 Cfp NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Slc6a4 Cyp2d4 Cyp3a73 Cyp2c11 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sptlc1 Acer2 Cerk Sptlc2 Enpp1 Degs2 Samd8 B4galt2 Sphk2 Ugcg Sdr16c5 Ugt8 Gla HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Sod1 Cat Sod3 Sod2 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Cyp3a73 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Bche Abcb1a Abcg2 Ces2h Ces1d Abcc1 Top1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Serpinc1 Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ren1 Ace Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Sdhd Sdhc Sdhb Mdh1 Sdha Cs Idh3g Tktl1 H6pd Mpc1 Pfkm Fh Idh1 Idh3a Pdhx Aldoc Gls Acly Rpia Ogdh Aco1 Pgk2 Gpi Slc16a1 Ireb2 Taldo1 Bckdhb Pkm Eno1 Glud1 Slc2a13 Cad Gapdhs Bpgm PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcb1a Ralbp1 Abcc1 Abcc3 Cdkn1a Tp53 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Ptpn6 Ghr Stat5a Stat5b Rps6ka1 Slc2a4 Sos1 Map2k1 Jak2 Mapk1 Ins2 Grb2 Raf1 Plcg1 Hras Prkca Shc1 Mapk3 Irs1 Insr KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Slc14a2 Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Aqp3 Aqp2 Atp6v1b1 Slc4a1 Atp1b1 Scnn1a Scnn1b Atp1b3 Scnn1g Atp1b2 Ca1 Ren1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd2 Gpd1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Grhpr Pklr Mdh1 Aldh2 Glo1 Hagh Acat1 Me1 Acaca Acyp1 Acot12 Pc Pck1 Pdhb Akr1b1 Dlat Dld DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3c3 Vac14 Pik3cd Prex1 Inpp5f Plce1 Pik3r4 Inppl1 Zfyve16 Ptpmt1 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Ripk2 Prkdc Jun Parp1 Cflar Pak2 Lmnb1 Map3k1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Map2k4 Fas Fadd Faslg Daxx Dffa Dffb Mapk8 Faf1 Arhgdib Map3k7 Pak1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcb1a Abcg2 Abcc1 Slco1b2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Mpc1 Agxt Aars2 Gpt Pc HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpia Tpi1l2 Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ren1 Ace Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Serpinc1 Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Ugt2b1 Ugt1a2 Slc22a8 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Cyp2c11 Alox12 Erp29 Prxl2b Cyp2u1 Ugt2b7 Ugt1a1 Alox5 Hspa5 Lta4h Akr1c18 Slc22a6 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc7a8 Slc7a9 Slc6a20a Aqp1 Slc22a2 Slc22a6 Ca1 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc4a4 Slc7a5 Slc9a1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Epo Ptpn6 Jun Epor Stat5a Fos Sos1 Map2k1 Jak2 Grb2 Raf1 Plcg1 Hras Mapk8 Shc1 Elk1 Mapk3 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp2d4 Oprm1 Ugt2b7 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Fbp1 Pgls Tkt Aldob Rpia Pgm1 Prps1 Gpi Pfkl Rpe G6pdx HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gclc Ggt6 Gclm Gsto2 Anpep Oplah Casp7 Gpx1 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sptlc1 Cerk Sptlc2 Degs2 Arsa Sphk2 Acer1 Ugcg Sgpl1 Acer3 Enpp7 Galc Plpp1 Neu3 B4galt6 Sgms1 Ugt8 Kdsr Sgpp2 Glb1 Gla GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Abat Dpyd Gad1 Aoc3 Cndp1 Aldh2 Upb1 Dpys Aldh6a1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Abcc8 Cacna2d2 Gnaq Gnb1 Plcb1 Cacna1a Slc2a2 Prkca Cacnb1 Chrm3 Adcy10 Vamp2 Rab3a Rapgef4 Glp1r Camkk1 Itpr3 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Prkacb Ppp1ca Gnb1 Creb1 Gngt1 Htr6 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin1 Cyp3a9 Cyp2b2 Cyp2d4 Oprm1 Grin2a PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Mettl6 Scly Slc39a8 Cbs Mat2a Cth Ahcy GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Prkacb Ptgdr Gnb1 Adcy2 Gngt1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gbe1 Gys1 Ganab Pgm2 Gpi PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Fah Tat Pah Yars1 Hpd Farsa Farsb Hgd Got1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Srf Gnb1 Itpr1 Akt1 Plcb1 Rock1 Lpar4 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Cpt2 Abcd1 Pex14 Crat Pex13 Acsl1 Crot Pex11g Slc25a20 Abcd2 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sptlc1 Cerk Sptlc2 Degs2 Arsa Sphk2 Acer1 Ugcg Sgpl1 Acer3 Enpp7 Galc Plpp1 Neu3 B4galt6 Sgms1 Ugt8 Kdsr Sgpp2 Glb1 Gla 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Ugt2b17 Hsd17b1 Cyp19a1 Cyp17a1 Ugt2b34l1 Sts Akr1d1 Sult2b1 Srd5a1 Hsd17b3 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Arg1 Glud1 Ass1 Got2 Cps1 Gpt Slc25a15 Slc1a5 Slc1a4 Asl Otc Gls2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Abat Asrgl1 Nars1 Gad1 Cad Asns Ass1 Aspa Ddo Dars1 Asl Adsl CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Nfkbia Rela Map2k1 Mapk1 Nfkb1 Itpr1 Plcb1 Raf1 Prkcb Mapk3 Hras LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Cyp2e1 Acss1 Ddc Aldh1b1 Comt Aoc1 Aldh2 Dct Hgd Got1 Haao Aldh3a1 Mif Cat Dbh Tyr Fah GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ptpn6 Ghr Stat5a Stat5b Rps6ka1 Slc2a4 Map2k1 Jak2 Mapk1 Gh1 Ins2 Grb2 Raf1 Plcg1 Hras Prkca Shc1 Mapk3 Irs1 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Mpc1 Agxt Aars2 Gpt Pc MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Acadm Abat Acss1 Bckdhb Echs1 Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Ldhal6b Aldh6a1 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Galt Uxs1 Gale Ugp2 Galk1 Pgm1 Ugdh Gck PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Prkca Akt1 Plcb1 Pik3cg Pik3r6 Vav1 Plcg1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Sirt1 Npr1 Rora Nmnat2 Clock Nmnat1 Nampt Nqo1 Ppargc1a CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Ugt2b34l1 Gusb Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Cox15 Cpox Urod EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Prkacb Ppp1ca Gnb1 Creb1 Gngt1 Htr7 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Arg1 Glud1 Ass1 Got2 Cps1 Gpt Slc25a15 Slc1a5 Slc1a4 Asl Otc Gls2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Ptgs1 Pdia2 Sdf2l1 Ptgs2 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Cyp2c11 Erp29 Ugt2b7 Ugt1a1 Hspa5 Slc22a6 Ugt2b1 Ugt1a2 Slc22a8 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Aldoart2 Slc2a1 Pkm Eno1 Pfkp Pgam2 Gpi Galm Tpi1l2 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Cyp1a2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Dlg1 Prkar1b Abcc8 Prkar2a Kcnj11 Prkar2b Abcc9 Atp1b4 Cacna2d2 Uqcr11 Cacna1g Cacna1h Slc9a1 Hcn4 Prkacb Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cacna2d2 Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Cyp1a2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Aox1 Chrnb2 Chrna3 Cyp2b2 Fmo3 Chrna4 Ugt1a9 Cyp2a3 Ugt1a5 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Bbox1 Aldh9a1 Shmt1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Gpd2 Plpp1 Akr1b1 Agpat1 Gpam Lipc Gpd1 Lpl Aldh3a1 Plpp2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Abat Gad1 Gss Cps1 Gclc Gclm Gmps Gls2 Glud1 Nagk Qars1 Cad Gnpnat1 Gfpt1 Got2 Gpt Ppat XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Adk Gmps Tpmt Gmpr Adss2 Abcc4 Slc29a2 Pfas Abcc5 Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Slc28a3 Slc29a1 Aox1 Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Rac1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak2 Nme1 Nme2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Adk Gmps Tpmt Gmpr Adss2 Abcc4 Slc29a2 Pfas Abcc5 Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Slc28a3 Slc29a1 Aox1 Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Rac1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Mpst Ctns Cdo1 Gclc Cars1 Gclm Got1 Cth MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Jun Fos Map3k1 Map2k1 Grb2 Raf1 Map2k4 Hras Stat6 Rasa1 Csnk2a1 Jak1 Egf Stat3 Stat2 Stat1 Srf Egfr Sos1 Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Mapk3 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Mthfr Dhfr Slc46a1 Mthfd1l Mtfmt Ggh Mthfd1 Mthfd2 Mthfs Ftcd FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Aldoa Tpi1l2 Gmppa Pmm1 Mpi Uxs1 Sord Khk Akr1b1 Pfkfb1 Gmds Pfkl BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Aox1 Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Galt Uxs1 Gale Ugp2 Pgm1 Ugdh Galk2 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ren1 Ace Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gclc Ggt6 Gclm Gsto2 Anpep Oplah Casp7 Gpx1 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Ces1d Tymp Tyms Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Acp1 Enpp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Cacna2d2 Cacna1a Ugt2b35 Ugt2b1 Ugt1a2 Atp1a2 Atp1a1 Pdia2 Atp1a4 Sdf2l1 Fxyd2 Hyou1 Atp1a3 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Grin2a Kcnd2 Ugt2b7 Ugt1a1 Scn1b Hspa5 Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Acadl Hsd17b10 Echs1 Acads Acss3 Hadh Acaa2 Acat1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Arg1 Glud1 Ass1 Got2 Cps1 Gpt Slc25a15 Slc1a5 Slc1a4 Asl Otc Gls2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Gnpat Cept1 Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Chst11 Suox Papss2 Sult1a1 Sult2b1 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ren1 Ace Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ptgs1 Ptgs2 Cyp2d4 Cyp2c11 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak2 Nme1 Nme2 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1a2 Atp1a1 Atp1b1 Atp1a4 Fxyd2 Atp1b3 Treh Atp1b2 Atp1a3 Slc5a1 Slc2a2 Gck PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Grhpr Pklr Mdh1 Aldh2 Glo1 Hagh Acat1 Me1 Acaca Acyp1 Acot12 Pc Pck1 Pdhb Akr1b1 Dlat Dld HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Aox1 Slc6a4 Cyp3a9 Maob Cyp2d4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Glud1 Slc2a4 Gpt Slc1a4 Slc25a22 Slc38a4 Slc2a2 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Dck Nme1 Dctd Tyms Rrm2b Slc28a3 Cmpk1 Rrm2 Slc29a1 Ctps1 Slc28a1 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Sdhd Pklr Sdhc Sdhb Mdh1 Sdha Cs Dhtkd1 Slc2a2 Idh3g Pc Pgk1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh3a Dlst Slc1a5 Pdhb Idh3b Aco2 Rpia Aco1 Dlat Gpi Slc16a1 Dld Pfkl Hk2 Taldo1 G6pdx Tkt Pkm Eno1 Pgam2 Gls2 Glud1 Pgls Aldob ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Aldoart2 Sdhb Mdh1 Sdha Cs Dhtkd1 Pc Pgk1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Rpia Aco1 Dlat Gpi Dld Hk2 Taldo1 G6pdx Pkm Eno1 Pfkp Tktl2 Pdha2 Slc16a4 Slc1a2 Gls2 Glud1 Slc2a1 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Hsd17b7 Msmo1 Nsdhl Dhcr24 Ebp Sc5d Dhcr7 Cyp51a1 Lbr ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Mtor Mapk1 Jak1 Stat3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Ces2h Ces1d Oprm1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Cct3 Ipmk Bpnt2 Impa1 Pik3c3 Isyna1 Vac14 Becn1 Plcb4 Ptpmt1 Synj1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Map2k1 Akt1 Chuk Raf1 Bad Bcl2l1 Hras Vav3 Rala Ralbp1 Casp9 Pld1 Rhoa Ralgds Cycs Elk1 Smad3 Smad4 Apaf1 Foxo4 Mapk3 Rac1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Gnaq Gnb1 Agtr1 Cyp21a1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Fbp1 Tkt Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Th Ddc ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Egfr Abcg2 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Mpst Ctns Cdo1 Gclc Cars1 Gclm Got1 Cth ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Srf Gnb1 Itpr1 Akt1 Plcb1 Rock1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Cyp2b2 Cyp3a73 Aldh1a1 Cyp2c11 Aldh3a1 Cyp2a3 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Map2k2 Pdpk1 Foxo1 Slc2a4 Sos1 Map2k1 Mapk1 Ins2 Akt1 Grb2 Pik3cg Pik3r6 Raf1 Hras Mapk8 Shc1 Irs1 Insr Irs2 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Grhpr Pklr Mdh1 Aldh2 Glo1 Hagh Acat1 Me1 Acaca Acyp1 Acot12 Pc Pck1 Pdhb Akr1b1 Dlat Dld PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rps26 Rps27 Rps29 Lars1 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ipmk Nudt3 Bpnt2 Impa1 Ip6k1 Isyna1 Ppip5k1 Synj1 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Cpt2 Abcd1 Pex14 Crat Pex13 Acsl1 Crot Pex11g Slc25a20 Abcd2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Impa1 Pik3c3 Vac14 Becn1 Plcd4 Pik3r4 Synj1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gclc Ggt6 Gclm Gsto2 Anpep Oplah Casp7 Gpx1 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Ephx1 Cyp3a9 Cyp2b2 Cyp3a73 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Pcna Ccnb1 Rb1 Ccne1 Ccnd1 Gadd45b Cdkn1a Cdk4 Cdk2 Cdk1 E2f1 Bax Bcl2 Apaf1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C8a Cfb C1qb C1qa Serping1 C1s C1r Masp2 C2 Cfd C4 C3 C1qc C5 Mbl2 C6 C7 C9 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma3 Psmb7 Psma6 Psma5 Psmb6 Psmc2 Psmb1 Psmc1 Psmc4 Psma2 Psmb3 Psmc3 Psma1 Psmd4 Psmb2 Uba1 Ubd Psmd13 Psma4 Psmb5 Ubc Psmc6 Psmc5 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Gpd2 Plpp1 Akr1b1 Agpat1 Gpam Lipc Gpd1 Lpl Aldh3a1 Plpp2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Actn4 Jun Atf4 Map3k1 Map2k1 Mapk1 Grb2 Raf1 Hras Erbb4 Cga Itpr1 Plcb1 Prkcb Prkca Gna11 Mapk8 Src Fshb Lhb Pld1 Gnrh1 Gnrhr Elk1 Hbegf Map2k7 Camk2a Adcy5 Calm2 Cdc42 Egr1 Mmp14 Lrrc7 Mmp2 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Cyp2e1 Nat1 Xdh Cyp1a2 Cyp2c11 Cyp2a3 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cacna2d2 Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Ugt2b7 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Fbp1 Aldoa Fcsk Fpgt Gfus Tpi1l2 Pmm1 Aldob Mpi Sord Khk Akr1b1 Pfkfb1 Gmds Pfkl BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Aldoart2 Slc2a1 Pkm Eno1 Pfkp Gpi Hk2 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Ppp3ca Jun Ppp3cb Syk Fos Map3k1 Nfatc4 Cd79b Nfatc3 Map2k1 Nfatc2 Lyn Ppp3cc Orai1 Grb2 Btk Blnk Raf1 Hras Sos1 Vav1 Prkcb Plcg1 Prkca Mapk8 Shc1 Elk1 Mapk3 Rac1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Srf Gnb1 Itpr1 Akt1 Plcb1 Rock1 Lpar1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Hmgcl Oxct1 Acat1 Bdh1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Abat Asrgl1 Nars1 Gad1 Cad Asns Ass1 Aspa Ddo Dars1 Asl Adsl LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pisd Pcyt1a Cept1 Chka Pcyt2 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Ambra1 Itpka Miox Ptpmt1 Plcd1 Cct3 Impa1 Isyna1 Vac14 Becn1 Sacm1l Inpp1 Pik3r4 Synj1 Itpk1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Endog Cad Dffa Casp7 Casp3 Hmgb2 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkacb Prkar1b Prkar2a Prkar2b Adcy10 Gnb1 Prkaca Gngt1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Kars1 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Aldoart2 Fbp1 Rbks Pfkp Rpia Tktl2 Pgm1 Prps1 Gpi Taldo1 Rpe G6pdx TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Ugt8 Gpi Gusb CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C8a C1qb C1qa C1s C1r C2 C4 C3 C1qc C5 C6 C7 C9 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Pfkm Aldob Bpgm Pkm Eno1 G6pc1 Slc2a2 Pgam2 Gpi Galm Tpi1l2 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Fbp1 Pfkfb2 Aldoa Sord CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacna2d2 Cacnb1 Ins2 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Ugt8 Gpi Gusb NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Aox1 Pnp Nmnat2 Bst1 Nudt12 Nnmt Nnt Enpp1 Nmrk1 Qprt Nadsyn1 Nampt SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Ugt2b34l1 Gusb Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Cox15 Cpox Urod PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Ugt2b34l1 Gusb Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Cox15 Cpox Urod ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Sord Gpi ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Ptgs1 Pdia2 Sdf2l1 Ptgs2 Hyou1 Pdia6 Pdia4 Cyp3a73 Ppib Dnajb11 Abcc3 Erp29 Ugt1a1 Hspa5 Abcb1a IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Slc22a1 Gab2 Cbl Crkl Abcb1a Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Chit1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Wars1 Tdo2 Kynu Cyp1a1 Acmsd Ido1 Ddc Aldh2 Aadat Haao Cat Aanat Tph1 Asmt Kmo Inmt Wars2 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Traf6 Ikbkg Nfkbia Sdhd Rela Slc25a1 Sdhc Mdh1 Sdhb Myd88 Sdha Nfkb1 Cd14 Cs Chuk Tirap Pfkp Tlr4 Me1 Acaca Acly Ikbkb HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Prkacb Gnb1 Adcy2 Avpr2 Gngt1 Fshr COAGULATION%SMPDB%SMP0000586 Coagulation F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Cyp2e1 Acss1 Aldh1b1 Aldh2 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Gpd2 Plpp1 Akr1b1 Agpat1 Gpam Lipc Gpd1 Lpl Aldh3a1 Plpp2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Gars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Galt Gaa Akr1b1 Gale Ugp2 Glb1 G6pc1 Pgm1 Lct B4galt1 Gla BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Hsd17b7 Msmo1 Nsdhl Dhcr24 Ebp Sc5d Dhcr7 Cyp51a1 Lbr TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Fah Tat Pah Yars1 Hpd Farsa Farsb Hgd Got1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcb1a Abcg2 Abcc1 Slco1b2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Sirt1 Nmnat2 Aifm2 Tp53 Nmnat1 Cd38 Nampt Nqo1 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Me1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh2 Got2 Idh3a Dlst Slc1a5 Pdhb Slc1a4 Idh3b Acly Aco2 Dlat Slc16a1 Dld Slc38a5 Gls2 Glud1 Slc7a7 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpia Tpi1l2 Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1a2 Atp1a1 Atp1b1 Atp1a4 Fxyd2 Clcnkb Atp1b3 Atp1b2 Atp1a3 Slc12a6 Ren1 Slc12a1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Mthfr Dhfr Slc46a1 Mthfd1l Mtfmt Ggh Mthfd1 Mthfd2 Mthfs Ftcd GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Arg1 Glud1 Ass1 Got2 Cps1 Gpt Slc25a15 Slc1a5 Slc1a4 Asl Otc Gls2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Th Ddc SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Nfkbia Gnaq Map2k1 Gnb1 Mapk1 Nfkb1 Raf1 Plcg1 Hras Cxcl12 Ptk2b Pxn Pik3c2g Ptk2 Bcar1 Cxcr4 Gnai1 Crk Mapk3 Gngt1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ren1 Ace Agtr1 Agt DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Cacna2d2 Cyp2d4 Cacna1a Cyp3a9 Aox1 Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Maob Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Abat Gad1 Gss Cps1 Gclc Gclm Gmps Gls2 Glud1 Nagk Qars1 Cad Gnpnat1 Gfpt1 Got2 Gpt Ppat WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Pfkm Aldob Aldoc Fbp2 Tpi1l2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Cyp1a2 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Mpc1 Agxt Aars2 Gpt Pc TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Traf2 Jun Ikbkg Nfkbia Map3k1 Nfkb1 Chuk Map2k4 Mapk8 Atf1 Casp2 Ripk1 Tank Map2k7 Tnf Map2k6 Map4k2 Ikbkb Map2k3 Mapk14 Tradd Cradd TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Aldh3a2 Slc27a2 Hacl1 Abcd1 Phyh Abcd2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Prkca Akt1 Plcb1 Pik3r6 Plcg1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Hadhb Acadl Cpt2 Echs1 Hadh Acaa2 Cpt1a Acsl1 Slc25a20 Hadha INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Ipmk Impa1 Nudt4 Ip6k2 Isyna1 Ppip5k1 Inpp1 Itpka Inpp4a 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Fbp1 Pank3 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Aldob Bpgm G6pc1 Gpi PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Cacna2d2 Chrna3 Cacna1a Fmo3 Aox1 Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Ugt1a9 Grin2a Ugt1a5 Cyp2a3 Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Cyp2b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Ugt2b34l1 Gusb Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Cox15 Cpox Urod GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sptlc1 Cerk Sptlc2 Degs2 Arsa Sphk2 Acer1 Ugcg Sgpl1 Acer3 Enpp7 Galc Plpp1 Neu3 B4galt6 Sgms1 Ugt8 Kdsr Sgpp2 Glb1 Gla LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Uroc1 Hdc Hnmt Carnmt1 Aoc1 Aldh2 Hars1 Prmt3 Cndp2 Aldh3a1 Cndp1 Ftcd Hal PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Iars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Got2 Mdh2 Slc25a11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Cmpk2 Upp2 Dctd Dpyd Uckl1 Itpa Rrm2 Cad Cant1 Nme6 Tymp Tyms Dhodh Rrm2b Cda Upb1 Gda Dpys Ctps1 Ak3 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Sardh Chdh Bhmt Mat2a Slc44a1 Aldh7a1 Gnmt Mtr Dmgdh Shmt2 Shmt1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C8a Masp2 C2 C4 C3 C5 Mbl2 C6 C7 C9 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Ces1d Tymp Tyms Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Abat Dpyd Gad1 Aoc3 Cndp1 Aldh2 Upb1 Dpys Aldh6a1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Mpc1 Mdh1 Pdhb Acly Me1 Slc25a11 Pc CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Abcb1a P2ry12 Cyp2b2 Cyp3a73 Cyp1a2 Cyp2c11 Pon1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacna2d2 Cacnb1 Ins2 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Abat Gad1 Gss Cps1 Gclc Gclm Gmps Gls2 Glud1 Nagk Qars1 Cad Gnpnat1 Gfpt1 Got2 Gpt Ppat ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Adra1a Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hadhb Mecr Ppt1 Hsd17b10 Echs1 Acaa2 Hadha THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Cmpk2 Upp2 Dctd Dpyd Uckl1 Itpa Rrm2 Cad Cant1 Nme6 Tymp Tyms Dhodh Rrm2b Cda Upb1 Gda Dpys Ctps1 Ak3 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Map2k2 Syk Map2k1 Mapk1 Lyn Akt1 Grb2 Btk Raf1 Pik3r1 Lat Map2k4 Hras Il13 Pla2g4a Fcer1a Il4 Il5 Kras Pdk1 Ms4a2 Nras Inpp5d Csf2 Lcp2 Sos1 Plcg1 Gab2 Prkca Vav3 Mapk8 Map2k7 Tnf Map2k6 Map2k3 Fyn Mapk14 Rac1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway H6pd Prpsap1 Pfkm Rbks Aldob Fbp2 Rpia Gpi Taldo1 Tktl1 Rpe THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Gls2 Suclg1 Glud1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Aldoart2 Fbp1 Rbks Pfkp Tktl2 Pgm1 Rpe Pgls Rpia Gpi Prps2 Taldo1 G6pdx SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nos3 Prkca Ikbkg Mapk1 Nfkb1 Plcb1 Mapk3 Creb1 Ikbkb METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Abat Asrgl1 Nars1 Gad1 Cad Asns Ass1 Aspa Ddo Dars1 Asl Adsl ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Cdo1 Ggt6 Csad Ado SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Adk Gmps Tpmt Gmpr Adss2 Abcc4 Slc29a2 Pfas Abcc5 Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Slc28a3 Slc29a1 Aox1 Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn Rac1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Fbp1 Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl Taldo1 G6pdx QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Btg2 Hoxb9 Btg1 Prmt1 Ngf Fgf1 Rb1 Ccnd1 Tp53 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacna2d2 Cacnb1 Ins2 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1b1 Trpv4 Prkg2 Gucy1a1 Trpc7 Trpc4 Kcnq4 Trpc3 Kcnq3 Kcnq2 Nos3 Gucy1a2 Adcy10 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2d4 Cyp1a2 Cyp2c11 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Dck Nme1 Sult1a1 Abcc3 Pcyt2 Slc22a1 Pgk1 Slc22a3 Abcc4 Slc22a2 Chpt1 Abcb1a Abcg2 Pcyt1a Abcc1 Cmpk1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Abcb1a Slc6a2 Slc6a4 Cyp2d4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Galt Uxs1 Gale Ugp2 Galk1 Pgm1 Ugdh Gck ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Ptgs1 Pdia2 Sdf2l1 Ptgs2 Hyou1 Pdia6 Pdia4 Cyp3a73 Ppib Dnajb11 Abcc3 Erp29 Ugt1a1 Hspa5 Abcb1a OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Ugt8 Gpi Gusb ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Abat Gad1 Gss Cps1 Gclc Gclm Gmps Gls2 Glud1 Nagk Qars1 Cad Gnpnat1 Gfpt1 Got2 Gpt Ppat ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification As3mt Pnp Gsto1 Aqp9 Aqp7 Slc2a4 Slc2a1 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Fah Tat Pah Yars1 Hpd Farsa Farsb Hgd Got1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Nudt3 Impa1 Ip6k1 Isyna1 Ppip5k1 Inpp1 Itpka Itpk1 Synj1 Inpp4b PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Sars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Srf Lpar2 Gnb1 Itpr1 Akt1 Plcb1 Rock1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Aldob Gapdhs Bpgm G6pc3 Pkm Eno1 Pfkp Pgk2 Gpi Galm Tpi1l2 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Abcc8 Cacna2d2 Cacnb1 Gcg Scn5a Cacna1a Slc2a2 Snta1 Sntb1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Fbp1 Aldoa Fcsk Fpgt Gfus Tpi1l2 Pmm1 Aldob Mpi Sord Khk Akr1b1 Pfkfb1 Gmds Pfkl BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Cpt2 Abcd1 Pex14 Crat Pex13 Acsl1 Crot Pex11g Slc25a20 Abcd2 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Prkacb Gnb1 Ptgir Adcy2 Myl3 Mylk Gngt1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Tlr6 Traf6 Tlr5 Tlr3 Ikbkg Tlr2 Nfkbia Rela Map3k1 Nfkb1 Chuk Map2k4 Myd88 Cd14 Tirap Tlr4 Mapk8 Ecsit Tollip Ikbkb Irak1 Map3k7 Mapk14 Tlr7 Tab2 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Cyp3a73 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Bche Abcb1a Abcg2 Ces2h Ces1d Abcc1 Top1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency H6pd Prpsap1 Pfkm Rbks Aldob Fbp2 Rpia Gpi Taldo1 Tktl1 Rpe QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Vnn1 Pank1 Ppcdc Enpp1 Coasy METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Fbp1 Tkt Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ren1 Ace Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Map2k2 Pdpk1 Jun Nfkbia Map3k1 Atf2 Arhgef7 Mapk1 Nfkb1 Adora2a Akt1 Chuk Braf Map3k4 Nfkb2 Prkcz Rap1a Hras Rapgef3 Rapgef2 Mapk11 Creb1 Gngt1 Prkacb Rps6ka1 Gnb1 Bad Mapk8 Elk1 Map2k7 Map2k6 Ikbkb Pak1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Mthfr Dhfr Slc46a1 Mthfd1l Mtfmt Ggh Mthfd1 Mthfd2 Mthfs Ftcd SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Acadm Abat Acss1 Bckdhb Echs1 Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Ldhal6b Aldh6a1 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hadhb Mecr Ppt1 Hsd17b10 Echs1 Acaa2 Hadha ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Tars1 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Sdhd Pklr Sdhc Sdhb Mdh1 Sdha Cs Dhtkd1 Pgk1 Suclg1 Mpc1 Fh Slc1a3 Idh1 Idh3a Dlst Pdhb Gls Idh3b Aco2 Rpia Aco1 Dlat Gpi Slc16a1 Dld Pfkl Hk2 Taldo1 G6pdx Tkt Pkm Eno1 Pgam2 Glud1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Galt Uxs1 Gale Ugp2 Galk1 Pgm1 Ugdh Gck PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rps26 Rps27 Rps29 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rpl35 Rps15 Rpl37 Rpsa Rpl8 Rpl39 Rpl9 Rps10 Rpl38l1 Rps11 Rps20 Rps24 Rpl7 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rps6 Rplp2 Rpl24 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl14 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcb1a Ralbp1 Abcc1 Abcc3 Cdkn1a Tp53 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Adra1a Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ren1 Ace Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Sdhd Sdhc Mdh1 Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Uroc1 Hdc Hnmt Carnmt1 Aoc1 Aldh2 Hars1 Prmt3 Cndp2 Aldh3a1 Cndp1 Ftcd Hal CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Pde4d Cyp3a73 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadhb Acadm Echs1 Hadh Acaa2 Slc25a20 Hadha ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Chst11 Suox Papss2 Sult1a1 Sult2b1 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Cyp19a1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Akr1c1 Akr1d1 Erp29 Ugt1a1 Hspa5 Cyp11b3 Hsd11b1 Srd5a1 Hsd17b3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Cyp2b2 Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt2b7 Ugt1a1 Hspa5 Ugt2b35 Ugt2b1 Ugt1a2 Oprm1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency H6pd Prpsap1 Pfkm Rbks Aldob Fbp2 Rpia Gpi Taldo1 Tktl1 Rpe KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Cyp1a2 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pisd Cept1 Chka Ptdss1 Pcyt2 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Yars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Aldob Gapdhs Bpgm G6pc3 Pkm Eno1 Pfkp Pgk2 Gpi Galm Tpi1l2 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Plcd3 Pik3c3 Fig4 Ambra1 Itpka Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Isyna1 Vac14 Becn1 Inpp1 Pik3r4 Itpk1 Ippk PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2d5 Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hadhb Ehhadh Hsd17b10 Ivd Cyp2b2 Acadsb Cyp2c11 Ugt1a2 Cyp2a3 Hadha PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Dars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1a2 Atp1a1 Atp1b1 Atp1a4 Fxyd2 Atp1b3 Atp1b2 Atp1a3 Slc5a1 Slc2a2 Lct CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ren1 Ace Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Scn5a Snta1 Sntb1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Cyp2b2 Cyp2d4 Cyp3a73 Aldh1a1 Cyp2c11 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Egfr Erbb4 Erbb3 Psen1 Nrg2 Adam17 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Cap1 Ccnd3 Wasf1 Map3k1 Cfl1 Pcna Ppp1r12b Actb Cdk5 Ccnd1 Myl2 Limk1 Cdkn1a Arfip2 Pdgfra Rps6kb1 Vav3 Ralbp1 Pld1 Mylk Pak1 Rac1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Aldoa Pfkm Pklr Bpgm Eno1 G6pc1 Pgam2 Slc2a2 Gpi Galm Hk2 Pgk1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sptlc1 Cerk Sptlc2 Degs2 Arsa Sphk2 Acer1 Ugcg Sgpl1 Acer3 Enpp7 Galc Plpp1 Neu3 B4galt6 Sgms1 Ugt8 Kdsr Sgpp2 Glb1 Gla GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugt8 Gpi Gusb NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Traf6 Ikbkg Nfkbia Rela Map3k1 Myd88 Nfkb1 Chuk Tlr4 Tnfrsf1b Il1a Tnfrsf1a Fadd Il1r1 Camkk2 Map3k14 Ripk1 Tnf Camkk1 Ikbkb Irak1 Ubc Map3k7 Tradd METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cacna2d2 Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Cyp2b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Atp4a Sstr4 Atp4b Chrm3 Ca1 Cckbr Sst Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Sdhc Sdhb Mdh1 Cs Slc2a2 Idh3g Pc Pgk1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh3a Pdhx Dlst Slc1a5 Pdhb Idh3b Aco2 Rpia Ogdh Aco1 Gpi Slc16a1 Dld Pfkl G6pdx Tkt Pkm Eno1 Pgam2 Glud1 Pgls Aldob CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gclc Ggt6 Gclm Gsto2 Anpep Oplah Casp7 Gpx1 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sptlc1 Cerk Sptlc2 Degs2 Arsa Sphk2 Acer1 Ugcg Sgpl1 Acer3 Enpp7 Galc Plpp1 Neu3 B4galt6 Sgms1 Ugt8 Kdsr Sgpp2 Glb1 Gla PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Ugt2b34l1 Gusb Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Cox15 Cpox Urod ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Ugt2b17 Hsd17b1 Cyp19a1 Cyp17a1 Ugt2b34l1 Sts Akr1d1 Sult2b1 Srd5a1 Hsd17b3 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Chdh Bhmt Mat2a Aldh7a1 Mtr Ahcy BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ren1 Ace Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Cars1 Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Grb2 Bad Pik3r1 Tp53 Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Mtor Myc Mdm2 Cdkn1b Crk Skp2 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Mpc1 Agxt Aars2 Gpt Pc CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Abcb1a Ces2h Abcg2 Ces1d Slco1b2 Impdh2 Cyp3a73 Ugt1a9 Impdh1 Ugt2b7 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Aldh1a1 Dnajb11 Erp29 Cyp2a3 Ugt1a1 Hspa5 Cyp2b2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Cacna2d2 Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Fah Ddc Comt Aoc1 Dct Hgd Got1 Haao Aldh3a1 Mif Dbh Tyr CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway Abcb1a P2ry12 Cyp2b2 Cyp3a73 Cyp1a2 Cyp2c11 Pon1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Duox2 Slc5a5 Duox1 Tpo Tg Cyba Cybb Nox4 Nox3 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Fbp1 Pmm2 Tgds Fcsk Amigo3 Fpgt Gfus Tpi1l2 Aldob Mpi Sord Khk Akr1b1 Pfkfb1 Pfkl INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Map2k2 Pdpk1 Jun Nfkbia Adora2b Map3k1 Atf2 Arhgef7 Mapk1 Nfkb1 Adcy2 Akt1 Chuk Braf Map3k4 Nfkb2 Prkcz Rap1a Hras Rapgef3 Rapgef2 Mapk11 Creb1 Gngt1 Prkacb Rps6ka1 Gnb1 Bad Mapk8 Elk1 Map2k7 Map2k6 Ikbkb Pak1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Aldoa Pfkm Pklr Bpgm Eno1 G6pc1 Pgam2 Slc2a2 Gpi Galm Hk2 Pgk1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Abcc8 Cacna2d2 Cacnb1 Sst Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Tsc2 Eif4ebp1 Tsc1 Ins2 Eif4e Akt1 Pik3cg Pik3r6 Rps6kb1 Mtor Irs1 Slc7a5 Insr Irs2 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Hmgcl Oxct1 Acat1 Bdh1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Hif1a Tlr4 Il1b Sirt3 Nlrp3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a73 Ugt1a9 Ugt2b7 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Grhpr Pklr Mdh1 Aldh2 Glo1 Hagh Acat1 Me1 Acaca Acyp1 Acot12 Pc Pck1 Pdhb Akr1b1 Dlat Dld REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Cacna2d2 Cacna1a Oprk1 Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Prkacb Ppp1ca Gnb1 Creb1 Gngt1 Htr4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Hsd17b1 Pdia2 Cyp1a1 Sdf2l1 Hyou1 Comt Pdia6 Pdia4 Cyp3a73 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Actn4 Jun Atf4 Cacna2d2 Map3k1 Cacna1f Cacna1d Map2k1 Mapk1 Grb2 Raf1 Hras Map3k2 Cga Cacna1c Egfr Sos1 Itpr1 Plcb1 Prkcb Prkca Gna11 Mapk8 Src Fshb Lhb Pld1 Cacnb1 Gnrh1 Gnrhr Elk1 Hbegf Map2k7 Camk2a Prkaca Egr1 Mmp14 Map2k3 Mapk14 Lrrc7 Mmp2 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Pik3c3 Inpp5j Ambra1 Itpka Miox Ptpmt1 Inpp4a Plcd1 Cct3 Ipmk Impa1 Isyna1 Vac14 Becn1 Sacm1l Pik3r4 Itpk1 Ippk Bpnt1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Acadm Echs1 Acat1 Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadvl Acaa2 Cpt1a Acsl1 Acadsb ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Traf6 Jun Tlr3 Ikbkg Tlr2 Fos Nfkbia Rela Map3k1 Nfkb1 Chuk Map2k4 Eif2ak2 Ppara Myd88 Cd14 Tirap Tlr4 Mapk8 Elk1 Map2k6 Ecsit Tollip Ikbkb Irak1 Map2k3 Map3k7 Mapk14 Tlr7 Tab2 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Gpam Gpd1 Crls1 Ptpmt1 Cds2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Ppp3ca Jun Ppp3cb Fos Nfkbia Rela Map3k1 Nfatc4 Nfatc3 Map2k1 Nfkb1 Nfatc2 Lck Ppp3cc Grb2 Rasgrp1 Raf1 Pik3r1 Lat Map2k4 Hras Zap70 Sos1 Pik3cg Vav1 Prkcb Plcg1 Prkca Mapk8 Shc1 Ptpn7 Cd3g Cd247 Elk1 Cd3d Mapk3 Ubc Fyn Rac1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Aox1 Gmps Adk Tpmt Abcc4 Slc29a2 Hprt1 Abcc5 Ppat Xdh Slc28a3 Slc29a1 Impdh1 Rac1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacna2d2 Cacnb1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkca Prkcb P2ry2 Plcg1 Ptk2b MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Chdh Msrb3 Mthfr Msrb2 Srm Bhmt Cbs Mat2a Cth Amd1 Shmt1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Cmpk2 Upp2 Dctd Dpyd Uckl1 Itpa Rrm2 Cad Cant1 Nme6 Tymp Tyms Dhodh Rrm2b Cda Upb1 Gda Dpys Ctps1 Ak3 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Ppp3ca Prkca Prkacb Dlg4 Grin1 Aldh2 Itpr1 Nos1 Xdh Grin2a METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Aldoart2 Sdhd Sdhc Sdhb Mdh1 Sdha Cs Dhtkd1 Pc Pgk1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh3a Dlst Pdhb Gls Rpia Aco1 Dlat Gpi Dld Taldo1 G6pdx Pkm Eno1 Pfkp Tktl2 Pgam2 Slc16a4 Glud1 Pgls Slc2a1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Aox1 Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Abat Gad1 Gss Cps1 Gclc Gclm Gmps Gls2 Glud1 Nagk Qars1 Cad Gnpnat1 Gfpt1 Got2 Gpt Ppat JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Pik3cd Pip4k2a Plcb1 Pik3r1 Pikfyve Vac14 Becn1 Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cacna2d2 Cyp2d4 Cyp3a73 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Cyp2c11 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Mpst Ctns Cdo1 Gclc Cars1 Gclm Got1 Cth BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Abcc4 Nr1h4 Slco1a4 Slc10a2 Gpbar1 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Hacl1 Cpt2 Abcd1 Pex14 Crat Pex13 Acsl1 Aldh2 Slc25a20 Phyh Abcd2 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Serpinc1 Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Fbp1 Aldoa Mdh2 Eno1 Pank4 Pgam2 Slc25a11 Galm Tpi1l2 Pck1 Mpc1 G6pc1 Gpi Hk2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Cant1 Galt Slc2a1 Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Cacna2d2 Cacna1a Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Grin2a Kcnd2 Scn1b Chrnb2 Pomc Drd1 Grin1 Atp1b1 Slc6a2 Cacnb1 Slc6a4 Atp1b3 Slc6a3 Atp1b2 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Cyp2c11 Erp29 Ugt1a1 Hspa5 Cyp2b2 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Grhpr Pklr Mdh1 Aldh2 Glo1 Hagh Acat1 Me1 Acaca Acyp1 Acot12 Pc Pck1 Pdhb Akr1b1 Dlat Dld TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Hsd17b10 Aldh2 Acads Acaa2 Acadsb Dld Bcat1 Aldh6a1 Auh Aox1 Acadm Hmgcl Abat Oxct1 Hmgcs2 Bckdhb Mccc1 Echs1 Ivd Hibadh Bckdha Mccc2 Pccb Dbt Acat1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sptlc1 Cerk Sptlc2 Degs2 Arsa Sphk2 Acer1 Ugcg Sgpl1 Acer3 Enpp7 Galc Plpp1 Neu3 B4galt6 Sgms1 Ugt8 Kdsr Sgpp2 Glb1 Gla 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Hsd3b1 Cyp11b3 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1c1 Akr1d1 Cyp21a1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Sds Amt Gatm Gars1 Aldh2 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh Sars1 Agxt Psph Dld Cth Gamt Shmt1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Aldoa Pfkm Pklr Eno1 G6pc1 Pgam2 Gpi Galm Hk2 Tpi1l2 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Prkacb Pomc Mc2r Gnb1 Gngt1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugt8 Gpi Gusb IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Cyp2b2 Cyp3a73 Aldh1a1 Cyp2c11 Aldh3a1 Cyp2a3 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Ppp3ca Prkca Prkacb Dlg4 Grin1 Nos1 Calm2 Grin2a AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Hsp90aa1 Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Jun Srf Stat5a Fos Map3k1 Map2k1 Jak2 Grb2 Raf1 Prkcb Plcg1 Hras Prkca Mapk8 Shc1 Rasa1 Erbb4 Csnk2a1 Elk1 Map2k7 Egf Stat3 Mapk3 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Srf Gnb1 Akt1 Lpar6 Rock1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Fbp1 Aldoa Fcsk Fpgt Gfus Tpi1l2 Pmm1 Aldob Mpi Sord Khk Akr1b1 Pfkfb1 Gmds Pfkl GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Ugt8 Gpi Gusb PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Aldoa Pfkm Pklr Eno1 G6pc1 Pgam2 Gpi Galm Hk2 Tpi1l2 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Arg1 Pycr2 Eprs1 Ass1 Gatm Cps1 Dao Rars2 Slc25a15 P4ha3 Nos1 Ckb Got1 Asl Prodh1 Otc Glud1 Gamt Oat BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Ch25h Amacr Acox2 Hsd17b4 Lipa Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gclc Ggt6 Gclm Gsto2 Anpep Oplah Casp7 Gpx1 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Pfkm Aldob Aldoc Fbp2 Tpi1l2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Hars1 Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Fbp1 Tkt Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls Rpia Gpi Pfkl Taldo1 G6pdx DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Fxyd2 Atp1a3 Slc22a2 Nr3c2 Slc22a6 Scnn1a Atp1b1 Scnn1b Scnn1g Atp1b3 Slc1a1 Atp1b2 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Prkacb Cga Ppp1ca Lhb Gnb1 Adcy2 Lhcgr Creb1 Gngt1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1a2 Atp1a1 Atp1b1 Atp1a4 Fxyd2 Atp1b3 Atp1b2 Atp1a3 Slc5a1 Slc2a2 Lct FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Fbp1 Aldoa Pank1 Slc37a4 Mdh2 Eno1 Pgm1 Pgam2 Slc2a2 Slc25a11 Galm Pc Tpi1l2 Pck1 Mpc1 Bpgm G6pc1 Gpi Hk2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Gpd2 Plpp1 Akr1b1 Agpat1 Gpam Lipc Gpd1 Lpl Aldh3a1 Plpp2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Pkm Pfkp Gpi Tpi1l2 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Fbp1 Tkt Aldoa Rbks Rpia Prps1 Gpi Pfkl Taldo1 G6pdx SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Gbe1 Pgm2l1 Ugt2b34l1 Gys2 Agl Pygl Pgm1 Ugdh Gusb Ugp2 Gpi Amy2a3 Hk2 Gck TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Agpat1 Gpam Dgat1 Gpd1 Lpin1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Gnaq Gnb1 Ren1 Ace Agtr1 Agt CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Abat Dpyd Gad1 Aoc3 Cndp1 Aldh2 Upb1 Dpys Aldh6a1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Agl Pygl Ugp2 Ugt2b1 Ugdh Gpi Amy2a3 Gusb Hk2 Gck 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Acmsd Dlst Dhtkd1 Dld Aldh8a1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Wars1 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ipmk Nudt3 Impa1 Ip6k1 Isyna1 Ppip5k1 Inpp1 Itpka Itpk1 Ippk Inpp4a Inpp4b ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F3 F7 F8 F9 Ggcx F13b Vkorc1 Fgb Serpinc1 Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Gcdh Echs1 Hadh Dlst Dhtkd1 Aadat Acat1 Pipox Aldh7a1 Dld Slc7a2 Aass ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Nfkb1 Itpr1 Plcb1 Prkcb MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Acadm Abat Acss1 Bckdhb Echs1 Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Ldhal6b Aldh6a1 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Ugt2b17 Hsd17b1 Cyp19a1 Cyp17a1 Ugt2b34l1 Sts Akr1d1 Sult2b1 Srd5a1 Hsd17b3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Mdh2 Eno1 Pank4 Galm Tpi1l2 Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Pck2 Fbp2 Gpi KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Atp1a2 Slc12a3 Atp1a1 Atp1a4 Fxyd2 Clcnkb Atp1a3 Aqp3 Aqp2 Slc8a1 Atp4a Atp1b1 Atp4b Atp1b3 Atp1b2 Ren1 Trpv5 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Arg1 Glud1 Ass1 Got2 Cps1 Gpt Slc25a15 Slc1a5 Slc1a4 Asl Otc Gls2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Fxyd2 Atp2a2 Atp1a3 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Map2k2 Syk Map2k1 Mapk1 Lyn Lck Akt1 Grb2 Blnk Raf1 Pik3r1 Lat Hras Il13 Fcer1a Il4 Kras Ms4a2 Nras Inpp5d Csf2 Plcg1 Gab2 Prkca Mapk8 Map2k7 Tnf Fyn Rac1 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ptgs1 Ikbkg Mapk1 Nfkb1 Plcb1 Chuk Nos3 Prkca Mapk11 Mapk3 Creb1 Ikbkb Sucnr1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Sult1a1 Fmo1 Cyp2b2 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Xdh Ada Prps1l1 Hprt1 Pde10a Adsl Gda Impdh1 Txn D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp1 Jun Prf1 Parp1 Arhgap32 Casp9 Casp8 Cycs Apaf1 Casp3 Arhgdib FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Pfkm Aldob Aldoc Fbp2 Tpi1l2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gclc Ggt6 Gclm Gsto2 Anpep Oplah Casp7 Gpx1 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rps26 Rps27 Rps29 Rpl5l1 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Nars1 Rps14 Rpl4 Rpl3 Rps18 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rpl39 Rps10 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rplp1 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Aldob Gapdhs Bpgm G6pc3 Pkm Eno1 Pfkp Pgk2 Gpi Galm Tpi1l2 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Prkacb Ppp1ca Gnb1 Adcy2 Hrh2 Creb1 Gngt1 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Lpar3 Gnb1 Itpr1 Akt1 Plcb1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Gls2 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME DATABASE ID RELEASE 97%10229202 Transport of nucleotide sugars Slc35d1 Slc35b4 Slc35a3 Slc35a2 Slc35b3 Slc35a1 Slc35b2 Slc35d2 Slc35c1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-RNO-8939247.1 RUNX1 regulates transcription of genes involved in interleukin signaling Elf1 Cbfb Runx1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Cd14 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%10228146 Activation of the pre-replicative complex Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Pole4 Dbf4 Orc5 Orc4 Orc6 Orc1 Orc3 Orc2 Cdt1 Gmnn Rpa1 Rpa2 Cdc7 Cdc6 Prim2 Rpa3 Cdk2 Prim1 Mcm3 Mcm4 Mcm5 Mcm10 Pole Mcm2 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling Ppp2r1b Ppp2r1a Plcb4 Plcb3 Pla2g4a Pdyn Plcb2 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Mapk1 Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Ppp2cb Prkar1b Ppp2ca Calm3 Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Gnaq Gng7 Pde4d Gng8 Gngt1 Gnat3 Prkar2a Cdk5 Pde1b Pde1c Gnb2 Pde1a Gnb1 Gnb4 Ppp2r5d Gnb3 Gnb5 Gng11 Gng12 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-RNO-2468052.1 Establishment of Sister Chromatid Cohesion Cdca5 Esco2 Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Esco1 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 97%10231498 Class I peroxisomal membrane protein import Abcd2 Pex13 Gdap1 Abcd3 Acbd5 Pex12 Pex3 Pex11b Pxmp4 Pxmp2 Pex19 Pex16 Fis1 Aldh3a2 Pex2 Abcd1 Pex26 Atad1 Pex14 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%10228956 Post-translational modification: synthesis of GPI-anchored proteins Fcgr3a Lypd6b Cd109 Rtn4rl2 Gpld1 Pigc Lypd8 Tecta Pigb Akp3 Lypd5 Lypd4 Alpp Lypd3 Negr1 Tex101 Lypd2 Piga Lypd1 Alpl Pigk Pigm Alpi Pigl Pigg Alpg Pigf Pigh Opcml Psgb1 Tectb Dpm1 Dpm2 Dpm3 Otoa Plaur Izumo1r Ly6g6d Ceacam1 Cd52 Prss21 Nrn1 Ntm Ceacam6 Gp2 Xpnpep2 Meltf Gpihbp1 Cgm4 Thy1 Art4 Art3 Atrnl1 Lsamp Reck Sprn Plet1 Pigs Pigu Pigt Pign Pigq Pigp Psca Spaca4 Cntn4 Pigw Msln Mdga1 Cntn3 Mdga2 Folr2 Pigv Pigx Bst1 Vnn1 Cntn5 Gpaa1 Psg29 Ly6e Ly6h Pgap1 Prnd Ly6d Prss41 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%10228346 Pyrophosphate hydrolysis Ppa1 Ppa2 Lhpp POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-110362.1 POLB-Dependent Long Patch Base Excision Repair Fen1 Lig1 Polb Parg Parp2 Apex1 Parp1 Adprs CAM PATHWAY%REACTOME%R-RNO-111997.1 CaM pathway Adcy8 Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption Slc2a2 Slc5a1 Slc2a5 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-RNO-9909648.1 Regulation of PD-L1(CD274) expression Prkag1 Prkag2 Ost4 Cops5 Ccnd1 Tmem258b Tusc3 Cdk4 Kmt2a Cul1 Kmt2c H2ac18 Cul3 Ezh2 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 B3gnt3 Csnk2a2 Dad1 Csnk2a1 Ywhag Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Wdr5 Ash2l Ddost Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Gsk3b Cd274 H2aj Os9 Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Pdcd1 Rnf5 Sel1l H2bc18 Nek2l1 Magt1 Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Mib2 Psmd1 Pdcd1lg2 Adrm1 Prkab2 Hist1h2ai Prkab1 Rps27a Skp1 Uba52 Btrc H2ab2 Rnf185 Prkaa1 Derl3 Ubb Derl2 H2ac4 Ubc Stt3b Rbx1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Psmb6l1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-RNO-419408.1 Lysosphingolipid and LPA receptors Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 S1pr4 Lpar3 Lpar1 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Chrnb2 Chrne Chrng Chrna4 Chrnb4 Chrna3 Chrnd NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-RNO-375165.1 NCAM signaling for neurite out-growth Spta1 Mapk1 St8sia4 Ptpra Col4a1 Col4a2 Ncam1 Sptbn1 Mapk3 Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Sptbn4 Nras Grb2 Fyn Kras St8sia2 Sos1 Hras Rps6ka5 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%10230950 ARL13B-mediated ciliary trafficking of INPP5E Inpp5e Arl13b Pde6d RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%10228278 Respiratory electron transport Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Cox7a2l Cox6a1 Cox6a2 Tmem126b Uqcrfs1 Nubpl Rnf113a1 Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Higd1c Coxfa4 Cox20 Cox6c2 Cycsl2 Cyc1 Got1 Got2 Hspa9 Cox6b1 Cox8a Cox6b2 Ndufv2 Ndufv1 Cox8c Yjefn3 Ndufv3 Uqcrb Cox18 LOC120097699 Mt-cyb Tmem177 Uqcrh Ndufab1 Ndufc2 Ndufa12 Ndufa11 Ndufa10 Cox7b Ndufs1 Timmdc1 Ndufs3 Ndufs2 Slc25a22 Ndufs5 Cox4i1 Ndufs4 Cox4i2 Ndufs7 Ndufs6 Mt-co3 Cox7c Ndufs8 Mt-co2 Cycs Slc25a18 Slc25a11 Slc25a12 Slc25a13 Fxn Ndufa5 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Nfs1 Cox7a1 Cox7a2 Cox5a Cox5b Mt-co1 Mdh1 Mt-nd5 Mdh2 Mt-nd4 Ecsit Mt-nd6 Ndufb1 Lyrm7 Hscb Mt-nd1 Ndufb3 Hccs Uqcrc2 Etfb Uqcrc1 Mt-nd3 Lyrm4 Ndufb5 Mt-nd2 Etfa Ndufb8 Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Uqcr10 Ttc19 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-RNO-381070.1 IRE1alpha activates chaperones Ern1 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%10228504 RNA Polymerase II Promoter Escape Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Taf4b Taf7l-ps1 Gtf2a1 Cdk7 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Taf4 Gtf2e1 Taf2 Taf1 Gtf2e2 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Taf9b Polr2j Taf15 Taf11 Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230018 Sphingolipid de novo biosynthesis Abcg2 Cers3 Cers2 Fa2h Cyb5b Abcc1 Sphk2 Sgms1 Spns2 Sphk1 Sgms2 Kdsr Sptlc1 Mfsd2b Sptlc2 Sptlc3 Ormdl2 Sptssa Degs2 Ormdl3 Degs1 Cers6 Cers5 Cers4 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-RNO-3928663.1 EPHA-mediated growth cone collapse Ngef Fyn Lyn Yes1 Src Rhoa TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-RNO-202430.1 Translocation of ZAP-70 to Immunological synapse ENSRNOG00000065955 Trbv16 RT1-Da Zap70 RT1-Db2 Cd247 Cd3g RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Ptpn22 RT1-Ba RT1-Bb IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-RNO-9732724.1 IFNG signaling activates MAPKs Ifngr2 Ifng Mapk1 Ifngr1 Raf1 Jak2 Mapk3 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229990 Metal ion SLC transporters Slc30a10 Slc24a4 Slc41a2 Slc24a3 Slc24a2 Slc24a1 Slc40a1 Slc41a1 Cp Slc39a4 Slc39a3 Slc39a2 Slc39a1 Calm3 Slc8a1 Slc39a8 Slc9a1 Slc39a7 Slc8a2 Slc39a6 Slc30a5 Slc9a4 Slc11a1 Slc9a5 Slc11a2 Slc9a2 Slc8a3 Slc9a3 Slc31a1 Slc9a8 Slc9a9 Slc30a8 Slc9a6 Slc9a7 Slc39a14 Slc30a1 Adam22 Heph Slc24a5 Slc8b1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-RNO-392154.1 Nitric oxide stimulates guanylate cyclase Pde1b Pde1a Pde10a Pde11a Nos3 Nos2 Prkg2 Pde5a Pde9a Prkg1 Pde2a Nos1 Irag1 Itpr1 THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome Aim2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%10229072 Signaling by Interleukins Ifnl3 Tec Il1r2 P4hb Il1r1 Il9r Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Grb2 Fyn Sos1 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Lyn Yes1 Cd4 Lck Jak2 Prkaca Il12b Il12a Il36a Crkl Stxbp2 Tbk1 Il23r Cntf Il20rb Il23a Il20ra Cntfr Il1rn Tslp Ebi3 Il31ra Il12rb1 Il12rb2 Tollip Lif Il1f10 Stx1a Gsdmd Stat5a Snap25 Stat5b Il36g Sdc1 Il10 Il11 Ctsg Stat6 Il15 Il13 Il1rap Il18 Il16 Il22ra2 Osmr Csf2rb Ifnlr1 Jak3 Vamp7 Tyk2 Syk Gab2 Vamp2 Vav1 Hck Il18r1 Pik3r1 Pik3r2 Pik3r3 Il33 Il6st Il34 Il10rb Hsp90b1 Il10ra Canx Stx4 Stx3 Inppl1 Il21 Il22 Il18bp Il11ra1 Il20 Il24 Clcf1 Osm Il27 Crlf1 Il1rapl1 Il1a Il22ra1 Rapgef1 Il1b Stat3 Stat1 Ctf1 Socs1 Socs3 Irs1 Irs2 Socs5 Lifr Sqstm1 Txlna Map3k3 Il36rn Csf1 Csf2 Inpp5d Brwd1 Shc1 Il2 Il4 Il3 Il6 Csf1r Il5 Il7 Il9 Irak4 Irak3 Pik3cb Il6r Pik3cd Il4r Pik3ca Myd88 Ptprz1 Il18rap Il2ra Il2rb Il15ra Il13ra2 Il1rl2 Il1rl1 Smarca4 Sos2 Rbx1 Il7r Crk Ywhaz Ptpn6 Cbl Ptpn11 Ifnl1 Casp3 Ptk2b Psmb6l1 Casp1 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 97%10230972 Activation of SMO Smo Grk2 Csnk1a1 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%10231750 Degradation of CRY and PER proteins Psmd8 Psmd2 Rps27a Per2 Per1 Psmd1 Per3 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%10229674 Breakdown of the nuclear lamina Lmna Casp6 Lmnb1 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-RNO-432722.1 Golgi Associated Vesicle Biogenesis Picalm ENSRNOG00000062839 Tbc1d8b Dnajc6 Arf1 Ocrl Ftl1 Ap3b1 Fth1 Clta Ap1b1 Cltc Sh3d19 Napa Necap1 Vamp8 Golgb1 Ap1s3 Ap1s2 Txndc5 Ap1g1 Tpd52l1 Dnm2 Rab5c Vamp7 Gak Tpd52 Ap4e1 Hip1r Vamp2 Dtnbp1 Sh3gl2 Yipf6 Snapin Snx2 Ap4b1 Fth1-ps5 Arrb1 Snx9 Ttgn1 Igf2r Snx5 Ap1m2 Bloc1s1 Ap1m1 Bloc1s3 Bloc1s4 Tfrc Bloc1s6 Pik3c2a Acbd3 Pum1 Hspa8 Sort1 Cpd PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10228806 Platelet calcium homeostasis Slc8a3 Atp2a1 Atp2b1 Atp2b4 Atp2a3 Atp2b3 Atp2a2 P2rx7 P2rx6 P2rx5 Adam22 P2rx4 Trpc7 P2rx3 P2rx2 P2rx1 Trpc3 Itpr3 Itpr2 Calm3 Slc8a1 Slc8a2 Itpr1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-RNO-2562578.1 TRIF-mediated programmed cell death Ticam1 Ripk3 Fadd Ripk1 Tlr4 Casp8 Ticam2 Ly96 Cd14 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%10228780 Thrombin signalling through proteinase activated receptors (PARs) Mapk1 Mapk3 Gna11 Gna14 Gng3 F2r Arrb2 F2 Gng5 F2rl2 Gng4 F2rl3 Gnaq Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Src Gng12 Arrb1 Gng10-ps1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling Il5 Csf2rb Jak3 Pik3cb Jak2 Pik3cd Gab2 Pik3ca Il2ra Pik3r1 Il2rb Pik3r2 Pik3r3 Grb2 Sos1 Csf2 Inpp5d Ptpn6 Inppl1 Shc1 Il2 Il3 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%10229690 ABC-family protein mediated transport Abcd2 Abcd3 Pex3 Pex19 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Abcc1 Psmb6 Psmb1 Psmb3 Psmb2 Os9 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Rnf5 Sel1l Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Abcf1 Abcb1 Abcb6 Abcb7 Abcb4 Abcb5 Abcb8 Abcb9 Abcg4 Abcc3 Abcg8 Abcc4 Abcg5 Abcc2 Abcc5 Abcc6 Apoa1 Abcc9 Abca12 Abcc10 Rnf185 Eif2s3 Eif2s2 Derl3 Ubb Eif2s1 Derl2 Cftr Ubc Abca2 Abca5 Abca6 Erlin2 Abca3 Kcnj11 Erlin1 Abca9 Vcp Abca7 Abca8 Abcd1 Psmb6l1 MEMBRANE TRAFFICKING%REACTOME%R-RNO-199991.1 Membrane Trafficking Copa Dynll1 Dynll2 Cops5 Syt2 Kif3a Syt1 Kif3b Gorasp1 Ccz1 Kif3c Syt9 Syt8 Use1 Dennd4c Copb2 Dennd4a Dennd4b Ywhae Copb1 Cope Stam2 Kif21a Kif21b Ubqln2 Chmp3 Chmp5 Dennd5a Dnm1 Chmp7 Ubqln1 Epn2 Chmp6 Epn1 Dnm3 Dennd5b Als2 Gosr1 Fnbp1 Gosr2 Lman1l Kif20a Sec24d Kif20b Kifap3 Sec24c Sec24b Dennd2a Sec24a Dennd2c Egf Reps1 Reps2 Dennd3 Spta1 Sptbn1 Sptb Sptbn2 Sptan1 Sptbn5 Sptbn4 Grb2 Src Cd3g Cd3d Cd4 Vamp7 Vamp2 Stx4 Il7r Cbl Picalm ENSRNOG00000062839 Tbc1d8b Dnajc6 Arf1 Ocrl Ftl1 Ap3b1 Fth1 Clta Ap1b1 Cltc Sh3d19 Napa Necap1 Vamp8 Golgb1 Ap1s3 Ap1s2 Txndc5 Ap1g1 Tpd52l1 Dnm2 Rab5c Gak Tpd52 Ap4e1 Hip1r Dtnbp1 Sh3gl2 Yipf6 Snapin Snx2 Ap4b1 Fth1-ps5 Arrb1 Snx9 Ttgn1 Igf2r Snx5 Ap1m2 Bloc1s1 Ap1m1 Bloc1s3 Bloc1s4 Tfrc Bloc1s6 Pik3c2a Acbd3 Pum1 Hspa8 Sort1 Cpd Arrb2 Cftr Cyth2 Cyth3 Lman1 Cyth4 Actr1a Lman2 Clvs1 Rab3il1 Vps36 Cyth1 Clvs2 Gja1 Gja3 Dctn1 Tfg Dctn2 Akt3 Gja5 Akt2 Gja4 Dctn4 Akt1 Slc18a3 Gja8 Rab11b Optn Rab11a Vti1a Bnip1 Vps25 Vps28 Itsn1 Dennd1a Bin1 Dennd1b Dennd1c Trappc2l Itsn2 Gabarap Kdelr2 Kdelr3 Gns Gjc1 Trappc10 Gjc2 Myo6 Rab33b Rab33a Scoc Tbc1d2 Fzd4 Tbc1d7 Snf8 Trappc12 Trappc11 Trappc13 Snap29 Gjb2 Gjb1 Kdelr1 Gjb4 Gjb3 Snap23 Gjb6 App Gjb5 Arf4 Arf3 Snx18 Als2cl Kifc1 Kifc2 Rabgef1 Chm Hbegf Tmed10 Cltb Rab27a Rps27a Rab39a Tbc1d14 Tbc1d13 Rab27b Tbc1d16 Tbc1d15 Tbc1d17 Trappc6b Trappc6a Agtr1 Vamp3 Sec31b Areg Uba52 Sec31a Vamp4 Gjd2 F8 Gjd4 Gjd3 Tbc1d20 Copz2 Sytl1 Tbc1d25 Tbc1d24 Arf6 Copz1 Arf5 Golga4 Golga2 Tmf1 Chml Golga1 Gps1 Uso1 Actr10 Ubap1 Stx6 Stx5 Ston1 Ston2 Ykt6 Chmp4bl1 Ubb Ric1 Ap2s1 Ubc Eps15l1 Trip10 Trip11 Arfip2 Pip5k1c Arcn1 Cenpe Rab43 Madd Tor1a Chmp2a Arfgap3 Chmp2b Arfgap2 Arfgap1 Tor1b Rab31 Ldlrap1 Nbas Rab35 Rab36 Rab38 Rab3gap2 Eps15 Rab3gap1 Egfr Scarb2 Gria1 Rab1b Ldlr Rabepk Arl1 Klc1 Dync1li2 Dab2 Rab5a Dync1li1 Rab4a Klc4 Klc3 Chrm2 Klc2 Dvl2 Bet1l Cops3 Cops4 Cops6 Ap4s1 Hps1 Cnih1 Synj1 Arpc3 Cops2 Gabarapl2 Arpc2 M6pr Cnih3 Hps4 Cnih2 Cops8 Rab3a Arpc5 Aak1 Pla2g4a Arpc4 Synj2 Syt11 Galnt1 Galnt2 Dnase2 Slc2a8 Ap2m1 Sh3gl3 Col7a1 Trappc9 Ppp6c Trappc8 Sh3kbp1 Tbc1d10c Sar1b Trappc5 Trappc4 Trappc3 Trappc2 Tbc1d10b Trappc1 Tbc1d10a Vps4a Vps4b Sh3gl1 Csnk1d Rhobtb3 Serpina1 Fnbp1l Rint1 Map1lc3b Rab21 Vps51 Vps52 Vps54 Grk2 Lrp2 Rab1A Mcfd2 Chmp4c Rab10 Rab13 Rab12 Rab14 Vps45 Rab18 Folr1 Bicd2 Bicd1 Agpat3 Bet1 Ins1 Scfd1 Fcho1 Ins2 Fcho2 Pafah1b3 Gcc2 Pafah1b2 Pafah1b1 Ereg Zw10 Cog1 Mvb12a Cog2 Cog3 Cog4 Preb Mvb12b Cog5 Cog6 Cog7 Cog8 Necap2 Vps37a Vps37b Vps37c Vps37d Ap1g2 Ank1 Ap4m1 Actr2 Avpr2 Btc Actr3 Arpc1a Ulk1 Tmem115 Rin3 Rin1 Rin2 Arfrp1 Gja10 Stam Mon1b Mon1a Agfg1 Sec23ip Akp3 Sec16b Rabgap1 Sec16a Alpp Usp6nl Rinl Cops7a Apob Gapvd1 Cops7b Hip1 Kif18a Ctsc Kif18b Alpi Kif19 Gdi1 Ppp6r3 Alpg Gdi2 Mia2 Mia3 Rab7a Dync1h1 Rab7b Tsg101 Tf Tmed9 Ctsz Kif11 Kif12 Kif15 Kif1c Tgfa Kif1a Kif1b Dync1i2 Kif6 Rab6b Rab6a Rab5b Dync1i1 Kif9 Stx16 Stx17 Rab3ip Stx18 Kif22 Avp Kif23 Kif28 Kif27 Kif16b Rab9a Rab9b Sec13 Ap2b1 Pla2g6 Racgap1 Gbf1 Tmed2 Tmed3 Copg1 Pacsin1 Copg2 Rab8b Pacsin3 Rab8a Tmed7 Pacsin2 Rgp1 Tjp1 Ankrd28 Ankrd27 Cd59 Nedd8 Cd55 Sys1 Kif4b Kif26b Kif4a Kif26a Sec22a Wnt5a Sbf2 Adrb2 Sbf1 Nsf Napb Kif5a Kif5b Tsc2 Kif13b Tsc1 Napg Sec23a Ap2a2 Ap2a1 Hgs Tacr1 Kif2a Kif2b Kif2c Dennd6a Dennd6b Grk3 Lman2l Amph Snap91 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-RNO-8849468.1 PTK6 Regulates Proteins Involved in RNA Processing Sfpq Khdrbs1 Khdrbs3 Khdrbs2 Ptk6 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 97%10229308 Cellular hexose transport Mfsd4b4 Fgf21 Slc2a1 Slc2a4 Slc2a3 Slc5a2 Slc2a7 Slc5a4 Slc2a2 Slc5a1 Slc2a9 Slc2a8 Slc2a12 Slc45a3 Slc2a10 Slc5a10 Slc50a1 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 97%10231112 Major pathway of rRNA processing in the nucleolus and cytosol Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Csnk1d Rps18 Rps19 Las1l Ltv1 Rpl35 Fcf1 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rrp9 Rpl6 Rps13 Pwp2 Rpl7 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Imp4 Rpl27 Rpl28 Rpp25 Rpl29 Rpl12-ps1 Ncl Rpl22 Xrn2 Rpl23 Snu13 Wdr75 Senp3 Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Pdcd11 Pno1 Rpl27a Rpl31l15 Rps20 Utp20 Rps21 Nop14 Rps23 Pelp1 Rps24 Rcl1 Utp25 Tbl3 Nol11 Rpp40 LOC100910714 Rps15a LOC102551819 Wdr3 Bud23 Dcaf13 Rps4x-ps13 Utp15 LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Rps3a Utp18 Wdr43 Rps27l Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Ddx49 Rpl35al8 Rps26-ps13 Wdr36 Rpl22l1 Ddx47 Rplp0 Rplp1 Rpl13a Rpl35al2 Csnk1e Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Nol9 Mphosph6 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Uba52 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rps3 Rps2 Rpl10a Exosc9 Rps4x Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Wdr18 Tsr1 Ubc Ddx21 Fau Rpl23a Wdr12 NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism Gemin5 Snrpg Snrpb Nup58 Gemin8 Nup37 Nup205 Pom121 Prmt5 Nup107 Sec13 Nup188 Tgs1 Tpr Smn1 Nup160 Snupn Rae1 Ndc1 Snrpd1 Nup85 Clns1a Nup42 Nup62 Nup43 Gemin7l1 Nup88 Aaas Snrpd3 Nup214 Ranbp2 Gemin2 Nup155 Nup133 Nup210 Nup153 Ddx20 Snrpepl2 Wdr77 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 REGULATION OF TP53 EXPRESSION%REACTOME%R-RNO-6804754.1 Regulation of TP53 Expression Tp53 MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling Lamtor5 Rptor Akt1s1 Lamtor3 Rraga Lamtor4 RragB Lamtor1 Eef2k Rragc Lamtor2 Fkbp1a Rragd Rps6 Eif4ebp1 Mtor Eif4e Rheb Rps6kb1 Mlst8 Slc38a9 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%10228362 Cap-dependent Translation Initiation Eif4ebp1 Eif4e Eif5 Eif1ax Eif4a2 Eif4a1 Pabpc1 Eif5b Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Rpl4 Eif3e Rps14 Eif3h Rps15 Eif3g Rpl5 Eif3b Rps16 Eif3a Rpl3 Eif3d Rps17 Eif3c Rps18 Eif2b3 Rps19 Eif2b2 Eif2b5 Eif2b4 Rpl35 Eif2b1 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a GPCR LIGAND BINDING%REACTOME%R-RNO-500792.1 GPCR ligand binding P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Tas2r40 Fpr2l1 Tas2r41 Hcar1 Adra2a Prokr2 Adra2c Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Calcr Cxcl12 Casr Cxcl10 C5ar2 C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Calcb Chrm1 Calca Hrh1 Chrm3 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Lpar5 Opn5 Plppr1 Sucnr1 Plppr4 Pyy Plppr5 Adora1 Plppr2 Adora3 Plppr3 Rln3 Ltb4r2 S1pr1 F2r Rln1 S1pr3 Cxcl16 S1pr2 F2 Cxcl13 S1pr5 F2rl2 Ucn S1pr4 F2rl3 Tas2r119 Lpar3 Opn1sw Lpar1 Prlhr Oxt Ece1 Ece2 Trh Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Qrfpr Insl3 Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 P2ry2 Ccl5 P2ry1 Ccl4 Ccl3 Hcrtr2 Hcrtr1 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Ackr4 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb App Agtr1 Chrm2 Pdyn Gng10-ps1 Oprm1 Adora2b Adora2a Ednrb Gng3 Ednra Sct Npff Pomc Rrh Gng5 Ptgdr Gng4 Htr4 Apln Trhr Gng7 Tas2r39 Htr6 Gng8 Oprd1 Gngt1 Htr7 Tas2r38 C3ar1 Crhbp Galr2 Galr3 Gnb2 Galr1 Cmklr1 Gnb1 Sstr5 Gnb4 Sstr4 Gnb3 Sstr3 Gnb5 Kel Gng11 Sstr2 Gng12 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Lhb Ppbp Fpr1 Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Vipr2 Nln Vipr1 Avpr2 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Ppy Tas2r135 Cga Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Brs3 Ptger4 Tas2r7 Gabbr1 Ptger2 Ptger3 Fshr Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Crhr1 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr2 Avp Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Taar5 Rgr Taar1 Hcrt Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Nps Cd55 Mc4r Ccl11 Ccl12 Ptafr Npw Npffr1 Npy Npffr2 Ghrh Adrb2 Ptgdr2 Rho Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Qrfprl Gpr4 Gcg Ptgdrl Tacr1 Qrfp Ccl27 Agt Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Mc3r NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%10230714 Nuclear Envelope Breakdown Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Lmna Tpr Lmnb1 Nup160 Prkca Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Cnep1r1 Ctdnep1 Emd Ccnb2 Nek9 Ccnb1 Plk1 Lpin3 Lpin2 Vrk1 Vrk2 Prkcb Banf1 Cdk1 Ccnb2-ps2 Nup93 Nup50 Nup35 Nup54 Nup98 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 97%10228984 Transcription from mitochondrial promoters Tfb2m Tfam Polrmt SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 97%10230566 Signaling by NOTCH1 Ubb Ubc Uba52 Rps27a Itch Dtx2 Dtx4 SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes Catsper4 Catsperb Catsper2 Hvcn1 Catsper3 Catsper1 Kcnu1 Catsperg Catsperd RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231572 RND2 GTPase cycle Vangl2 Golga3 Nudc Rnd2 Muc13 Wdr6 Txnl1 Kif14 Scrib Rbmx Ptpn13 Nisch Arhgap35 Dst Depdc1b Cav1 Fam83b Frs2 Ubxn11 Frs3 Kctd13 Epha2 Kidins220 Ktn1 Arhgap5 Plxnd1 Prag1 Arhgap1 Dlg5 Ankrd26 Fnbp1 Dsg1 Bltp3b Tnfaip1 Ckap4 Pik3r1 Pik3r2 Aldh3a2 Tfrc AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME%R-RNO-9938027.1 Affinity selection of immunoglobulins Actr1a Pold3 Rev1 Dynll1 Msh6 Dynll2 Msh2 Rilp Kif3a Ctsa Mcm3ap Kif3b RT1-DOa RT1-DOb Dctn1 Osbpl1a Kif3c Pms2 Dctn2 Mlh1 Rev3l Apex2 Poli Polh Dctn4 Klc1 Dync1li2 Dync1li1 Klc4 Klc3 Klc2 Kif18a Ctsc Kif20a Rab7a Dync1h1 Kifap3 Kif11 Kif15 RT1-Db2 RT1-Db1 Dync1i2 RT1-Ha Dync1i1 RT1-Ba RT1-Bb Kif22 RT1-Da Kif23 Rps27a Racgap1 Uba52 Kif4b Kif4a Kif26a Ctsb Ctsd Ctnnbl1 Actr10 Ctse Kif5a Sptbn2 Ctsf Kif5b RT1-DMb Actr1b Ctsh Ctsk Ctsl Ubb Ctso Ctss Ubc Exo1 Ifi30 Aicda Kif2a Rfc5 Kif2b Pold2 Kif2c Rfc3 Mad2l2 Cenpe Rfc4 Pcna Rfc1 Rfc2 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229078 FCERI mediated MAPK activation ENSRNOG00000069193 AABR07065813.1 Mapk10 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Vav3 ENSRNOG00000070192 Plcg1 Iglc1 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Vav2 Syk ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 Vav1 ENSRNOG00000070986 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Lcp2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Pak1 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 Mapk9 ENSRNOG00000063713 ENSRNOG00000062820 Pak2 Grap2 ENSRNOG00000064490 ENSRNOG00000066072 Mapk8 AABR07065781.1 ENSRNOG00000069901 Mapk1 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Lat ENSRNOG00000067643 Mapk3 Fos Shc1 Map3k1 Map2k7 Nras Grb2 Kras Sos1 Hras Jun ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%10231606 Atorvastatin ADME Abcc2 Cyp3a9 Pon3 Pon1 Slco1b2 Slco2b1 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Abcb1 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism Aldh1a1 Tkfc Glyctk Sord Aldob Akr1b1 Khk GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 97%10228718 GPER1 signaling Prkar1a Prkar2a Prkar1b Prkaca Prkacb Shc1 Itgb1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229324 FGFR2c ligand binding and activation Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Fgf16 Fgf17 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-RNO-5654712.1 FRS-mediated FGFR4 signaling Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Nras Grb2 Kras Sos1 Hras Frs2 Frs3 Ptpn11 Fgf16 Fgf17 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-RNO-1679131.1 Trafficking and processing of endosomal TLR Tlr9 Ctsk Tlr8 Ctsl Tlr7 Cnpy3 Ctss Hsp90b1 Ctsb Unc93b1 Lgmn PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229844 PD-1 signaling Prkag1 Prkag2 Ost4 Cops5 Ccnd1 Tmem258b Tusc3 Cdk4 Kmt2a Cul1 Kmt2c H2ac18 Cul3 Ezh2 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 B3gnt3 Csnk2a2 Dad1 Csnk2a1 Ywhag Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Wdr5 Ash2l Ddost Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Gsk3b Cd274 H2aj Os9 Psma7 H3-3b Psmc5 RT1-Db2 Hist3h2ba Psmc2 Cd247 Psmc1 Cd3g RT1-Db1 Psmc4 Psmc3 Cd3e Pdcd1 Cd3d Trav19 Rnf5 AC109737.1 Sel1l Cd4 H2bc18 RT1-Ha Nek2l1 Lck Magt1 Psmd7 RT1-Ba Psmd6 RT1-Bb H2az2 ENSRNOG00000065955 Psmd8 Trbv16 Psmd2 RT1-Da H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Mib2 Psmd1 Pdcd1lg2 Adrm1 Prkab2 Hist1h2ai Prkab1 Csk Rps27a Skp1 Uba52 Btrc H2ab2 Rnf185 Prkaa1 Derl3 Ubb Derl2 H2ac4 Ubc Stt3b Rbx1 Erlin2 Spop Erlin1 Ptpn6 Vcp Rpn2 Ptpn11 Rpn1 Ostc Prkag3 Psmb6l1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229322 FGFR1c ligand binding and activation Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Tgfbr3 Gipc1 Fgfr1 Fgf17 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-RNO-72764.1 Eukaryotic Translation Termination Apeh OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 97%10231362 OAS antiviral response Pde12 Rig1 Rnasel Oasl EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%10230810 EPH-Ephrin signaling Nck2 Git1 Sdcbp Mmp2 Mmp9 Epha1 Actr2 Epha3 Actb Epha4 Actr3 Arpc1b Arpc1a Epha5 Psenen Arhgef28 Epha6 Epha7 Psen1 Epha10 Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Rasa1 Sdc2 Ephb1 Ephb2 Itsn1 Ephb3 Rac1 Ephb4 Ephb6 Grin1 Vav3 Pak3 Actg1 Cdc42 Efnb1 Efnb2 Efnb3 Rlc-a Rock2 Vav2 Rock1 Arpc3 Efna4 Efna5 Grin2b Arpc2 Lyn Yes1 Src Rhoa Ngef Arpc5 Arpc4 Pak1 Pak2 Epha2 Ptk2 Fyn Hras Tiam1 Efna1 Efna2 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-RNO-5693532.1 DNA Double-Strand Break Repair Pold3 Rad50 Rad52 Eya2 Eya1 Ercc1 Eya4 Ercc4 Babam1 Eya3 Babam2 Topbp1 Rbbp8 Ubxn1 Psma4 Brca2 Psma3 Brca1 Psma6 Rad51ap1 Polh Polk Psma5 Uimc1 Psma2 Poll Psma1 Pole3 Rad1 Pole2 Psmd12 Pole4 Psmd11 Hist1h2bq Psmd14 Psmd13 Psmb5 Psmb4 Rpa1 Rpa2 Psmb7 Tp53 Psmb6 Psmb1 Rpa3 Cdk2 Psmb3 Psmb2 Psma7 Pole Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 H2bc6 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Rif1 Ppp4r2 Paxip1 Pias4 Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Lig3 Lig4 Dna2 Sirt6 Rad51c Blm Baz1b Rad51b Chek1 Mapk8 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Prkdc Rps27a Abl1 Palb2 Ube2n Firrm Ppp4c Nhej1 Clspn Rad17 Kpna2 Xrcc6 Xrcc3 Slx1b Xrcc2 Tdp2 Uba52 Xrcc5 Tdp1 Xrcc4 Xrcc1 Atm Atr Bap1 Ccna1 Ccna2 Tp53bp1 Ppp5c Apbb1 Phf6 Kdm4b Fen1 Kdm4a Lig1 Ddb1 Mus81 Cul4a Parp2 Pold1 Rmi2 Parp1 Fignl1 Rmi1 Pold4 Brip1 Cul4b Brcc3 Smarca5 Herc2 Ubb Polq Rnf168 Ubc Sumo1 Exo1 ABRAXAS1 Rbx1 Polm Sumo3 Rfc5 Rnf8 Pold2 Dclre1c Rfc3 Rhno1 Slx4 Rfc4 Wrn Pcna Nsd2 Rfc1 Spidr Psmb6l1 Rfc2 Rad51 P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors P2ry13 Lpar6 P2ry12 Gpr17 P2ry14 P2ry6 P2ry4 P2ry2 P2ry10 P2ry1 Lpar4 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Bnip3l Steap3 LOC134478826 Atm ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 97%10228366 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Rps25 Rps26 Rps27 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Rps15a Rps4x-ps13 Rps3a Rps27l Eif4ebp1 Eif4e Eif1ax Eif4a2 Rps26-ps13 Eif4a1 Pabpc1 Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Rps14 Eif3h Rps15 Eif3g Eif3b Rps16 Eif3a Eif3d Rps17 Eif3c Rps18 Rps19 Rpsa Uba52 Rps10 Rps11 Rps3 Rps2 Rps13 Rps4x Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Fau PI-3K CASCADE:FGFR2%REACTOME%R-RNO-5654695.1 PI-3K cascade:FGFR2 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Pik3ca Fgf9 Pik3r1 Grb2 Gab1 Frs2 Fgf10 Fgf3 Fgf22 Fgf7 Ptpn11 Fgf16 Fgf17 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229542 Disassembly of the destruction complex and recruitment of AXIN to the membrane Ppp2r1b Csnk1a1 Ppp2r1a Ppp2cb Ppp2ca Cav1 Lrp6 Ctnnb1 Ppp2r5b Ppp2r5a Dvl2 Dvl1 Dvl3 Wnt1 Amer1 Fzd1 Fzd2 Fzd5 Ppp2r5e Apc Axin1 Wnt8b Ppp2r5d Gsk3b Wnt8a Frat2 Frat1 SIGNALING BY BMP%REACTOME%R-RNO-201451.1 Signaling by BMP Acvr2a Ube2d1 Inhba Smurf2 Smurf1 Acvr2b Fstl1 Smad5 Smad6 Smad7 Chrdl1 Grem2 Bmp10 Acvrl1 Amhr2 Inha Amh Zfyve16 Cer1 Tgfbr3 Gdf2 Bmpr1a Bmpr1b Bmpr2 Smad1 Ski Bmp2 Smad4 Ube2d3 Smad9 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231156 Negative regulation of MET activity Sh3kbp1 Rps27a Hgf Sh3gl2 Lrig1 Eps15 Ptpn2 Sh3gl1 Usp8 Ptpn1 Met Stam Ubb Grb2 Stam2 Ubc Hgs Uba52 Cbl Sh3gl3 SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 97%10230086 Signaling by Hedgehog P4hb Kif3a Smo Csnk1a1 Cul1 Cul3 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Os9 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Adcy3 Sel1l Adcy4 Adcy1 Adcy2 Psmd7 Adcy7 Psmd6 Adcy8 Psmd8 Psmd2 Adcy5 Adcy6 Smurf2 Adcy9 Smurf1 Prkaca Prkacb Psmd1 Adrm1 Gpr161 Ihh Prkar1a Rpgrip1l Ulk3 Prkar1b Tulp3 Cdon Adcy10 Grk2 Dhh Ift140 Ptch1 Disp2 Scube2 Hhip Fuz Hhat Mks1 Ift52 Cdc73 Dzip1 Prkar2a Ttc21b Gli1 Ift57 Gli3 Gli2 Shh Numb Ift122 Ofd1 Intu Kif7 Evc Wdr35 Spopl Dync2h1 Gpc5 Evc2 Ift172 Wdr19 Notum Sufu Syvn1 Itch Rps27a Skp1 Uba52 Btrc Ubb Derl2 Ubc Rbx1 Spop Vcp Psmb6l1 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins Add1 Plec Casp8 Casp7 Gsn Casp6 Gas2 Casp3 Vim Mapt Sptan1 Sh3glb2 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-RNO-209931.1 Serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 Asmt NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231620 Negative Regulation of CDH1 Gene Transcription H2bc6 Rbbp4 H2bc4 Hist1h4m Mphosph8 H2bc1 Zmym2 Rbbp7 Hdac2 Ctbp1 H2ac18 Ctbp2 Hdac1 Ezh2 Twist1 Tle1 Hist1h2ai Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Suz12 Hist1h2bq Eed H2aj H2ab2 H3-3b Hist3h2ba H2ac4 Smarca4 H2bc18 H2az2 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230622 Abacavir transmembrane transport Slc22a2 Slc22a1 Slc22a3 TRKA ACTIVATION BY NGF%REACTOME%R-RNO-187042.1 TRKA activation by NGF Ntrk1 Ngf REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%10229364 Regulation of gap junction activity Gja1 Tjp1 Src PURINE SALVAGE%REACTOME DATABASE ID RELEASE 97%10228436 Purine salvage Adk Hprt1 Dck Aprt Ada Dguok Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Gmpr TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 97%10231034 TNFs bind their physiological receptors Tnfsf4 Tnfsf13b Eda Tnfrsf17 Tnfrsf25 Tnfrsf4 Tnfsf11 Tnfsf8 Tnfrsf8 Edaradd Tnfsf9 Edar Tnfrsf1b Tnfsf15 Tnfsf13 Tnfrsf9 Tnfrsf1a Tnfrsf11b Tnfsf18 Lta Eda2r Tnfrsf18 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10230766 WNT ligand biogenesis and trafficking Wnt2b Vps29 Snx3 Wnt1 Wnt5b Wnt9a Wnt7a Wnt5a Wnt9b Wnt10a Wnt2 Wnt4 Wnt8b Wnt16 Wnt8a Wls Wnt10b Wnt11 Vps26a Vps35 Tmed5 Wnt6 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 97%10230608 MHC class II antigen presentation Actr1a Dynll1 Dynll2 Rilp Kif3a Ctsa Kif3b RT1-DOa RT1-DOb Dctn1 Osbpl1a Kif3c Dctn2 Dctn4 Arf1 Klc1 Dync1li2 Clta Ap1b1 Cltc Dync1li1 Dnm1 Klc4 Klc3 Klc2 Ap1s3 Kif18a Ap1s2 Ctsc Dnm3 Ap1g1 Dnm2 Kif20a Rab7a Sec24d Dync1h1 Sh3gl2 Kifap3 Sec24c Sec24b Sec24a Kif11 Kif15 RT1-Db2 RT1-Db1 Ap1m2 Dync1i2 Canx Ap1m1 Ap2m1 RT1-Ha Dync1i1 RT1-Ba RT1-Bb Kif22 RT1-Da Sar1b Kif23 Sec13 Ap2b1 Cd74 Racgap1 Lag3 Sec31a Kif4b Kif4a Kif26a Ctsb Ctsd Actr10 Ctse Kif5a Sptbn2 Ctsf Kif5b RT1-DMb Actr1b Lgmn Ctsh Ctsk Ctsl Sec23a Ctso Ap2a2 Ctss Ap2a1 Ap2s1 Ifi30 Kif2a Kif2b Kif2c Cenpe ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling Nck2 Git1 Sdcbp Efnb1 Efnb2 Efnb3 Rlc-a Src Fyn Arhgef7 Pak1 Ephb1 Ephb2 Ephb3 Ephb4 Rac1 Ephb6 Pak2 Pak3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors Rdh11 Rdh10 Tbp Tbl1x Rdh13 Rdh14 Adh4 Pdha1 Adh1 Gtf2a1 Pdha2 Greb1 Gtf2a2 Cited1 H2ac18 Strn Prkcz Cav2 Egfr Esr1 Esr2 Abca1 Cdk9 Crebbp Akr1c3l1 Crabp1 Crabp2 Igf1r Rdh7 Hdac3 Pou2f1 Xpo1 Pdpk1 Hist1h2bq Prmt1 Tbl1xr1 Rara Foxo3 Mmp7 Mmp3 Zdhhc21 Ppard Fkbp4 Fkbp5 Ptges3 Akr1c1 Akr1c9 Sphk1 Dld Ncor2 Carm1 Aldh8a1 H2aj Ep300 Src Gps2 Akr1c12l1 H3-3b Zfp217 Foxa1 Egf Hist3h2ba Ncoa3 Kat2b Rarg Fabp5 Yy1 Cyp26c1 Dlat Cdkn1b H2bc18 Nr5a2 H2az2 H2bc6 H2bc4 Hist1h4m H2bc1 Gnai2 Gnai1 Hist1h2ai Gnai3 Calm3 Aldh1a1 S1pr3 Gnat3 Ptk2 Ereg Nras Nos3 Kras Hras Mmp2 Mmp9 Btc Akt3 Hdac1 Akt2 Kdm1a Akt1 Pik3r1 Pik3r2 Pik3r3 Kat5 Tgfa Cbfb Runx1 Atf2 Mapk1 Hbegf Mapk3 Areg Cav1 Fos Shc1 Dhrs4 Pdhx Dhrs3 Ppp5c Aldh1a2 Aldh1a3 Nrip1 Kdm4b Akr1c18 Akr1c19 Hsp90aa1 Cyp26b1 Akr1c21 Pdk4 Pdk3 Pik3ca Polr2c Dhrs9 Polr2a Ppid Pdk2 Polr2b Uhmk1 Polr2g H2ab2 Pdk1 Polr2h Sdr16c5 Polr2e Ppidl1 Polr2f Tle3 Nr1h3 Polr2i H2ac4 Nr1h2 Pdhb Polr2j Hsp90ab1 Rxrb Rxra Akr1c12 Cyp26a1 Akr1c13 Zdhhc7 Jun Gtf2f2 Pgr Gtf2f1 Gata3 Rxrg DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%10228706 DAG and IP3 signaling Adcy8 Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Prkce Adcy2 Camkk1 Adcy7 Camkk2 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Cbfb Runx1 Foxp3 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK Kalrn Arhgef7 Itsn1 Rac1 Vav3 Vav2 Vav1 Ngef Mcf2l Tiam2 Bcl2l11 Arhgef15 Arhgef17 Mapk8 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Sos2 Sos1 Tiam1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%10228168 Removal of the Flap Intermediate Pold3 Rpa1 Fen1 Rpa2 Prim2 Pold1 Rpa3 Prim1 Pold4 Pola2 Pola1 Pold2 Dna2 Pcna FATTY ACIDS%REACTOME DATABASE ID RELEASE 97%10228548 Fatty acids Cyp2j16 Cyp4f39 Adh7 Cyp2j3 Cyp4f1 Cyp2f2 Cyp4a14 Cyp2b1 Cyp4f3 Cyp4f40 Cyp4a12 Cyp4b1 Cyp2a2 Cyp4f4 Cyp4a10 Cyp2a1 Cyp2d4 Cyp4a2 Cyp2a3 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%10230196 Keratan sulfate keratin metabolism Glb1l3 Fmod Glb1l2 St3gal6 Galns St3gal4 St3gal2 Hexa Lum Hexb St3gal3 B4gat1 Omd St3gal1 Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan B3gnt3 Chst6 Glb1 Ogn Gns Slc35d2 Glb1l B3gnt7 B3gnt2 Kera B4galt4 B4galt5 B4galt6 Prelp RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 97%10230956 RHO GTPases activate IQGAPs Cdc42 Calm3 Clip1 Cdh1 Ctnna1 Iqgap2 Iqgap3 Rac1 Men1 Ctnnb1 ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 97%10229376 Endogenous sterols Pomc Arnt Ahr Cyp39a1 Cyp19a1 Ncoa2 Cyp11a1 Cyp1b1 Ahrr Cyp51a1 Cyp8b1 Cyp7b1 Nr1h4 Cyp4v2 Cyp21 Cyp46a1 Cyp27a1 Arnt2 Cyp11b1 Fdx1 Cyp11b3 Cyp11b2 Fdxr Fdx2 Cyp7a1 Rxra MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229048 MyD88 cascade initiated on plasma membrane Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 97%10229764 Degradation of the extracellular matrix Mmp2 Mmp9 Acan Cdh1 Ctsg Mmp7 Mmp3 Mmp24 Mmp25 Col18a1 Adam15 Optc Adam10 Bsg Htra1 ENSRNOG00000069479 Mmp20 Mmp11 Col26a1 Mmp12 Mmp13 Mmp14 Adamts5 Mmp15 Adamts4 Mmp16 Mmp17 Mmp19 Adam8 Mmp8 Dcn Try10 Prss2l1 Ctrb1 Mmp10 Capn15 Cast Col15a1 Col13a1 Plg Klkb1 Col19a1 Elane Bcan Phykpl Spp1 Furin Cma1 Try5 Cd44 LOC102554637 Scube3 Capn9 Capn8 Scube1 Capn5 Capn7 Capn6 Col25a1 Ctsb Capn1 Ctsd Timp1 Capn3 Capn2 Timp2 Prss2 Prss3 Tmprss6 Ctsk Mmp1b Ctsl Tpsb2 Prss1 Ctss Spock3 Capns1 Capn10 A2m Capn11 Capn12 Capn13 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 97%10230776 Regulation by c-FLIP Traf2 Fadd Ripk1 Casp8 Tradd Fas Cflar Faslg Tnfsf10 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%10228710 DARPP-32 events Ppp1ca Prkar2a Cdk5 Pde4a Pde4b Ppp2r1b Prkaca Ppp2r1a Prkacb Ppp2r5d Prkar1a Ppp2cb Prkar1b Ppp2ca Ppp1r1b Pde4c Pde4d AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228268 Amino acid and derivative metabolism Gamt Ckmt1 Ckmt2 Slc44a1 Slc44a2 Gls Mtap Dmgdh Tdo2 AC132020.1 Shmt1 Sds Slc6a11 Slc6a12 Psma4 Mccc1 Psma3 Tyrp1 Psma6 Mccc2 Ido2 Psma5 Hpd Psma2 Ido1 Psma1 Slc45a2 Pycr3 Pycr2 Aldh6a1 Slc22a4 Pycr1 Psmd12 Glud1 Psmd11 Kyat1 Oaz1 Oaz3 Psmd14 Oaz2 Psmd13 Dhtkd1 Ogdh Hao1 Asl Psmb5 Slc5a5 Psmb4 Mtrr Pnmt Psmb7 Tyr Psmb6 Gcsh Psmb1 Hal Hykk Psmb3 Adi1 Psmb2 Pah Glul Prodh1 Acadsb Prodh2 Psma7 Gpt Phgdh Psmc5 Ado Bhmt Psmc2 Th Psmc1 Auh Psmc4 Aadat Psmc3 Bhmt2 Agmat Slc25a21 Gcdh Folh1 Slc6a8 Arg2 Psmd7 Slc6a7 Psmd6 Arg1 Txndc11 Psmd8 Sdsl Psmd2 Enoph1 Slc25a15 Ivd Aass Slc25a10 Oca2 Oat Aldh4a1 Sqor Psmd1 Odc1 Hdc Adrm1 Gnmt Gatm Bbox1 Ckb Nqo1 Duox1 Ahcy Slc7a5 Aoc1 Ckm Fmo1 Sephs2 Fah Duox2 Kgd4 Echs1 Asrgl1 Otc Slc25a2 Amdhd1 Aldh9a1 Sat1 Txn2 Hsd17b10 Iyd Acat1 Serinc4 Serinc5 Crat Serinc2 Aldh18a1 Hgd Serinc1 Haao Gpt2 Dio1 Dio2 Dlst Dio3 Kmo Acad8 Rida Pipox Carns1 Sirt5 Mpst Naalad2 Mri1 Cps1 Tpo Qdpr Glyat Grhpr Aanat Duoxa1 Tph2 Duoxa2 Dao Ddc Tph1 Agxt2 Asmt Hibadh Azin2 Gadl1 Psph Azin1 Rimkla Rimklb Tat Amd1 Asns Aldh7a1 Mtr Dbh Bcat1 Nat8l Bcat2 Got1 Txnrd1 Got2 Dbt Hibch Ethe1 Pcbd1 Amt Carnmt1 Bckdhb Dct Tst Bckdha Gstz1 Crym Smox Gls2 Psat1 Suox Ddo Srm Tshb Il4i1 Srr Cbs Aspg Scly Slc3a2 Slc36a4 Nags Aspa Agxt Bckdk Usf1 Tmlhe Uroc1 Chdh Ftcd Kynu Cth Sardh Mat1a Ppm1k Cdo1 Slc25a12 Slc25a13 Cav1 Dld Cga Phykpl Psmb6l1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%10230708 Beta-catenin independent WNT signaling Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Clta Psmd12 Cltc Psmd11 Rac1 Ctnnb1 Psmd14 Psmd13 Dvl2 Dvl1 Dvl3 Wnt1 Psmb5 Psmb4 Fzd1 Fzd2 Psmb7 Fzd5 Psmb6 Psmb1 Psmb3 Psmb2 Rhoa Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Gng10-ps1 Ap2m1 Psmd7 Psmd6 Psmd8 Psmd2 Smurf2 Smurf1 Prkcg Psmd1 Adrm1 Prkca Calm3 Gng3 Arrb2 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Kras Fzd4 Prkcb Wnt11 Pde6g Pard6a Daam1 Ror1 Wnt5b Ror2 Pfn1 Gnao1 Nlk Tcf7l2 Cltb Ppp3ca Rps27a Map3k7 Wnt4 Fzd3 Ppp3cb Fzd7 Ap2b1 Fzd6 Fzd8 Rac2 Rac3 Nfatc1 Lef1 Ppp3r1 Camk2a Gnat2 Pde6a Uba52 Pde6b Prickle1 Wnt5a Ubb Ap2a2 Ap2a1 Ubc Ap2s1 Psmb6l1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%10228156 CDK-mediated phosphorylation and removal of Cdc6 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Cdc6 Psmb1 Psmb3 Cdk2 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Ccne1 Ccne2 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%10230930 BBSome-mediated cargo-targeting to cilium Rab3ip Smo Cct3 Bbs2 Cct2 Sstr3 Bbs10 Mkks Bbs12 Arl6 Ttc8 Tcp1 Lztfl1 Mchr1 Bbip1 Bbs7 Cct8 Bbs5 Bbs4 Cct5 Cct4 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-RNO-2534343.1 Interaction With Cumulus Cells And The Zona Pellucida Hyal5 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 97%10228560 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Hadha Echs1 Hadhb Acadl Hadh RAS PROCESSING%REACTOME DATABASE ID RELEASE 97%10231552 RAS processing Icmt Zdhhc9 Bcl2l1 Abhd17b Arl2 Abhd17a Prkcq Golga7 Fnta Lypla1 Fntb Abhd17c Rce1 ENSRNOG00000067432 Nras Prkg2 Kras Calm3 Hras Pde6d SWI SNF CHROMATIN REMODELERS%REACTOME%R-RNO-9932451.1 SWI SNF chromatin remodelers Ss18 Pbrm1 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Dpf1 Bicral Bicra Dpf2 Dpf3 Brd9 Brd7 Arid1a Arid1b Ss18l1 Bcl7a Bcl7b Actg1 Bcl7c Actl6a Phf6 Bcl11a Bcl11b Phf10 Smarce1 Smarcc1 Smarca2 Smarca4 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgfbp3 Fgf5 Fgfbp1 Fgf8 Fgf9 Fgf10 Fgf3 Fgf22 Fgf7 Fgf16 Fgf17 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling Nfkbia Psenen Psen1 Ywhae Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Ngf Itsn1 Rac1 Vav3 Vav2 Arhgdia Adam17 Vav1 Omg Mag Prkci Rhoa Ngfr Ngef Bex3 Rtn4 Itgb3bp Casp2 Mcf2l Ikbkb Tiam2 Bcl2l11 Arhgef15 Arhgef17 Mapk8 Arhgef16 Traf6 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Rps27a Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Nfkb1 Arhgef1 Obscn Fgd2 Arhgef9 Sqstm1 Fgd1 Fgd4 Arhgef37 Uba52 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Rela Ect2 Prex1 Trio Bad Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Myd88 Ubb Ripk2 Ubc Sos2 Sos1 Tiam1 Casp3 Irak1 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%10231332 Receptor Mediated Mitophagy Map1lc3b Map1lc3a Csnk2b Fundc1 Csnk2a2 Pgam5 Csnk2a1 Atg5 Atg12 Ulk1 Src REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 97%10229580 Regulation of pyruvate dehydrogenase (PDH) complex Gstz1 Pdha1 Pdha2 Pdk4 Dld Pdk3 Pdk2 Pdk1 Pdhb Dlat Pdp1 Pdpr Pdp2 Pdhx SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%10228616 Signaling by EGFR Fam83a Spry2 Sh3kbp1 Spry1 Fam83d Aamp Hbegf Btc Rps27a Lrig1 Eps15 Sh3gl1 Egfr Stam Stam2 Arhgef7 Areg Uba52 Gab1 Fam83b Shc1 Epn1 Cdc42 Plcg1 Pik3ca Sh3gl2 Src Pik3r1 Ereg Egf Nras Ubb Grb2 Ubc Csk Kras Tgfa Eps15l1 Hgs Sos1 Hras Cbl Ptpn11 Pxn Sh3gl3 Ptpn3 Ptpn12 Pag1 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 97%10230474 Synthesis of CL Crls1 P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB Nfkbia Traf6 Rps27a Myd88 Prkci Ngfr Nfkb1 Ubb Sqstm1 Ripk2 Ubc Uba52 Ngf Rela Ikbkb Irak1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses Gls Syt1 Slc6a11 Slc6a12 Glul Hspa8 Chrnb4 Chrna3 Chrnd Chrnb2 Chrne Chrng Chrna4 Slc18a3 Slc22a2 Slc22a1 Gls2 Myo6 Prkcb Camk2a Rps6ka3 Rps6ka1 Rps6ka2 Ap2s1 Gria1 Rab3a Gng10-ps1 Adcy3 Adcy4 Adcy1 Ap2m1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Adcy5 Adcy6 Adcy9 Cacng8 Aldh5a1 Prkaca Cacng4 Prkacb Cacng2 Prkcg Cacng3 Stxbp1 Slc18a2 Gnai2 Slc6a13 Gnai1 Abat Prkca Unc13b Gnai3 Grin2a Gabrg2 Camk4 Arhgef9 Gabrg3 Prkar1a Slc5a7 Grin3a Prkar1b Calm3 Tspoap1 Grik5 Gng3 Grik2 Grik1 Gnal Grik4 Grik3 Gng5 Grin2d Gng4 Grin2c Pick1 Gabra4 Gng7 Gabra3 Gabra6 Gng8 Gngt1 Gabra5 Gabra2 Gnat3 Gabra1 Prkar2a Akap5 Slc6a1 Slc6a4 Slc6a3 Gnb2 Maoa Lrrc7 Gnb1 Glra3 Gnb4 Glra2 Gnb3 Glra1 Gnb5 Gng11 Syn3 Gng12 Syn2 Syn1 Actn2 Cacna2d3 Cacna2d2 Camk1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Slc17a7 Cacnb3 Cacnb4 Grip1 Slc32a1 Cacnb1 Cacnb2 Gabrr1 Gabrr3 Gad1 Gabrr2 Gad2 Apba1 Gabrq Gabrb1 Gabrb3 Gabrb2 Nefl Cacna1e Cacna1a Cacna1b Chrnb3 Comt Naaa Grip2 Stx1a Rims1 Gria4 Gria3 Snap25 Kcnj3 Kcnj2 Gria2 Cask Epb41l1 Slc1a1 Slc1a3 Chat Slc1a2 Lin7a Grin1 Slc38a2 Slc1a7 Lin7b Slc1a6 Lin7c Slc38a1 Chrna2 Dlg1 Chrna1 Dlg2 Dlg3 Chrna7 Grin2b Gabbr1 Vamp2 Dlg4 Chrna6 Chrna5 Chrna9 Gabbr2 Dnajc5 Cplx1 Tomt Rps6ka6 Tspan7 Arl6ip5 Aldh2 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Camk2g Camk2d Camk2b Glrb Ncald Kcnj10 Kcnj12 Htr3b Htr3a Kcnj15 Kcnj16 Ap2b1 Nsf Ap2a2 Ap2a1 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%10231550 ALPK1 signaling pathway Ubb Tifa Traf6 Ubc Uba52 Rps27a Map3k7 Tab3 Alpk1 Tab2 Tab1 PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation Adcy8 Adcy5 Prkar2a Adcy6 Adcy9 Prkaca Prkacb Prkar1a Prkar1b Calm3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis Cyp19a1 Akr1b10 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-RNO-8850843.1 Phosphate bond hydrolysis by NTPDase proteins Entpd7 Entpd8 Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-RNO-141444.1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Nup160 Rps27 Nup85 Dync1li2 Clip1 Nup43 Dync1li1 Xpo1 Ranbp2 Ppp2r5b Ppp2r5a Kif18a Nup133 Ppp2r5e Dync1h1 Plk1 Itgb3bp Dync1i2 Dync1i1 Nudc Sec13 Clasp1 Clasp2 Spc24 Ppp2cb Birc5 Ppp2ca Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ppp2r5d Ahctf1 Mapre1 Zwint B9d2 Pafah1b1 Ska2l1 Bub1 Zw10 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%10230350 Cellular response to hypoxia Egln1 Egln2 Egln3 Epas1 Hif3a Ube2d2 Hif1an Psma4 Wtip Psma3 Ajuba Psma6 Hif1a Cited2 Psma5 Vhl Psma2 Limd1 Crebbp Psma1 Cul2 Eloc Elob Psmd12 Psmd11 Psmd14 Arnt Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ep300 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Ube2d3 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ubb Ubc Rbx1 Psmb6l1 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor Akt2 Kl Atp6v0b Gab1 Flt3 Fgf10 Trib3 Fgf3 Ide Fgf22 Atp6v0a4 Fgf7 Pdpk1 Grb10 Pik3c3 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Ptprf Them4 Pde3b Pik3r4 Atp6ap1 Gab2 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Pik3r1 Atp6v1b2 Pik3r2 Atp6v0d2 Fgfr3 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Mapk1 Mapk3 Irs1 Ptpn1 Irs2 Frs2 Shc1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Pik3cb Fgfr2 Ins1 Fgf6 Fgf5 Fgf8 Ctsd Ins2 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Tlr9 Grb2 Sos1 Fgfr1 Ptpn11 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Ccnc Trim33 Ube2d1 Rnf111 Smad2 Smurf2 Mapk1 Smad3 Wwtr1 Usp9x Ccnt2 Rps27a Rbl1 E2f4 Smad7 Mapk3 E2f5 Skil Hdac1 Cdk9 Uba52 Furin Men1 Ncor2 Parp1 Ubb Ubc Ppm1a Tgif1 Tgif2 Sp1 Ski Tfdp2 Tfdp1 Smad4 Ccnk Ube2d3 Atp1b4 INTERLEUKIN-6 SIGNALING%REACTOME%R-RNO-1059683.1 Interleukin-6 signaling Il6st Tyk2 Jak2 Il6r Stat3 Cbl Ptpn11 Stat1 Socs3 Il6 VITAMIN E TRANSPORT%REACTOME%R-RNO-8877627.1 Vitamin E transport Ttpa NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-RNO-350054.1 Notch-HLH transcription pathway Tbl1x Hdac2 Ncor2 Hdac1 Kat2a Maml3 Rbpj Hdac5 Hdac4 Crebbp Maml1 Kat2b Maml2 Hdac11 Hdac10 Notch3 Hdac9 Hdac3 Hdac8 Tbl1xr1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic Actr1a Dynll1 Dynll2 Dctn1 Dctn2 Rab3gap2 Pla2g6 Rab3gap1 Dctn4 Dync1li2 Dync1li1 Rab18 Bicd2 Bicd1 Agpat3 Dync1h1 Actr10 Pafah1b3 Pafah1b2 Pafah1b1 Pla2g4a Galnt1 Dync1i2 Galnt2 Rab6b Rab6a Dync1i1 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-RNO-5654727.1 Negative regulation of FGFR2 signaling Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Fgf10 Frs2 Braf Fgf3 Fgf22 Mknk1 Fgf7 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Src Ubb Grb2 Ubc Cbl Ptpn11 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism Abcd3 Osbpl1a Slco1b2 Akr1c3l1 Ch25h Amacr Hsd17b4 Osbpl3 Slco1a4 Cyp39a1 Osbpl2 Osbpl7 Ncoa2 Osbpl6 Baat Akr1c18 Osbpl9 Akr1c19 Hsd3b7 Abcc3 Scp2 Cyp8b1 Akr1d1 Cyp7b1 Akr1c1 Akr1c21 Slc10a1 Nr1h4 Akr1c9 Acox2 Fabp6 Stard5 Cyp46a1 Cyp27a1 Acot8 Alb Osbp Akr1c12l1 Slc27a5 Slc51a Slc27a2 Slc51b Abcb11 Cyp7a1 Rxra Akr1c12 Akr1c13 COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade Crp C1qa Cfh C3 Cfi C2 C4 Colec10 C5 C6 C9 Cd46 C1s Cfhr1 C1r Cpn1 Cpn2 Cd19 ENSRNOG00000069193 Cpb2 AABR07065813.1 C1qc ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 C5ar2 C5ar1 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Elane F2 Cd55 C3ar1 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Masp1 Masp2 C4b C1qb SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus Ippk Ipmk Ip6k1 Ip6k2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-RNO-1660516.1 Synthesis of PIPs at the early endosome membrane Pi4k2a Pik3r4 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Mtm1 Fig4 Pik3c2a Pik3c3 Vac14 Mtmr12 Mtmr4 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 97%10230694 Stimuli-sensing channels Ryr2 Asic5 Ryr1 Asic4 Fkbp1b Clca1 Clca2 Asic1 Asic3 Asic2 Clca4 Trdn Trpc5 Trpc1 Trpc4 Clcn2 Stoml3 Clcn1 Trpm2 Trpm1 Unc80 Ano10 Trpm8 Ano9 Trpm7 Ano8 Ano7 Ano6 Ano5 Trpm4 Ano4 Trpm3 Ano3 Trpm6 Ano2 Ano1 Ttyh3 Ttyh1 Raf1 Ttyh2 Rps27a Stom Sgk3 Sgk2 Sgk1 Trpv5 Trpc7 Trpv4 Trpv6 Scnn1a Scnn1b Trpc3 Clic2 Unc79 Scnn1g Mcoln3 Calm3 Asph Uba52 Lrrk1 Trpa1 Slc17a3 Trpv1 Trpv3 Mcoln1 Mcoln2 Trpv2 Nalcn Tpcn1 Trpc4ap Tsc22d3 Clcn6 Clcn7 Best4 Clcn4 Clcn5 Nek4 Wwp1 Bsnd Best1 Adam22 Best3 Clcnkb Clcnka Best2 Ubb Ubc SIGNALING BY VEGF%REACTOME%R-RNO-194138.1 Signaling by VEGF Nck2 Pgf Itgb3 Shc2 Bcar1 Nckap1 Elmo2 Elmo1 Hspb1 Vegfa Vegfd Vegfc Vegfb Akt3 Prkcz Mapk12 Wasf3 Akt2 Mapk13 Wasf2 Wasf1 Akt1 Jup Mapkap1 Mapk11 Axl Abi2 Cyba Ctnnd1 Rasa1 Abi1 Cybb Trib3 Ctnna1 Cyfip2 Cyfip1 Pdpk1 Rac1 Ctnnb1 Vav3 Pak3 Plcg1 Cdc42 Them4 Rock2 Vav2 Rock1 Sphk1 Vav1 Pik3r1 Src Rhoa Pik3r2 Prkcb Mtor Pak1 Mlst8 Pxn Pak2 Prkaca Prkacb Prkcd Prkca Calm3 Cav1 Hsp90aa1 Pik3cb Pik3ca Ptk2 Nrp1 Flt1 Nrp2 Nras Nos3 Prr5 Ncf1 Fyn Ncf2 Kras Flt4 Ncf4 Rictor Crk Hras Brk1 Itgav Shb Mapkapk3 Kdr Mapk14 Baiap2 Nck1 Mapkapk2 Sh2d2a Ptk2b Nckap1l TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-RNO-168181.1 Toll Like Receptor 7 8 (TLR7 8) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Cd14 Chuk Mapk10 Mapk11 Tasl Irf5 Slc15a4 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Tlr7 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10231708 Complex IV assembly Cox18 Cox20 Tmem177 Mt-co2 MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228620 MAPK3 (ERK1) activation Il6st Cdk1 Tyk2 Jak2 Il6r Mapk3 Ptpn11 Map2k1 Il6 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%10231686 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Morc2 Setdb1 H2bc6 Atf7ip Pphln1 H2bc4 Hist1h4m H2bc1 Mphosph8 H2ac18 H2aj Hist1h2ai H2ab2 H3-3b Hist3h2ba H2ac4 H2bc18 Hist1h2bq H2az2 Tasor P38MAPK EVENTS%REACTOME%R-RNO-171007.1 p38MAPK events Nras Mapk11 Kras Ralgds Hras Mapkapk3 Mapk14 Mapkapk2 CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine Tomt Slc6a3 Maoa Comt HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors Chrnb2 Chrna4 Chrna2 Chrna1 Chrna6 Chrna5 Chrnb4 Chrnb3 Chrna3 ARMS-MEDIATED ACTIVATION%REACTOME%R-RNO-170984.1 ARMS-mediated activation Rap1a Ntrk1 Crk Ngf Kidins220 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190372.1 FGFR3c ligand binding and activation Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Galnt3 Fgf5 Fgf8 Fgf9 Fgfr3 Fgf16 Fgf17 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses Gria1 Gria4 Gria3 Cask Epb41l1 Il1rap Grin1 Ptprf Dlg1 Shank1 Dlg2 Shank3 Dlg3 Ptprs Homer1 Dlg4 Grin2b Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Ppfibp2 Ppfibp1 Rtn3 Flot2 Flot1 Epb41l2 Epb41l3 Slitrk5 Epb41l5 Slitrk6 Slitrk3 Slitrk4 Slitrk1 Slitrk2 Lrrtm1 Lrfn2 Lrrtm2 Lrfn3 Lrrtm3 Lrfn4 Lrrtm4 Lrfn1 Il1rapl1 Dlgap1 Lrrc4b Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Il1rapl2 Nlgn3 Grin2a Ntrk3 Grin2d Grin2c Grm1 Grm5 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Sh3glb2 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%10231104 Events associated with phagocytolytic activity of PMN cells Lpo Mpo CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects Pde11a Prkg2 Pde5a Pde1b Pde9a Prkg1 Pde2a Pde1a Irag1 Itpr1 Pde10a ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-RNO-114294.1 Activation, translocation and oligomerization of BAX Bax Bid CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10230040 Cell-extracellular matrix interactions Arhgef6 Vasp Tesk1 Ilk Fermt2 Actn1 Fblim1 Parvb Pxn Flna Itgb1 Parva Flnc RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%10231780 Ribosome-associated quality control Ube2d2 Psma4 Psma3 Psma6 Psma5 Psma2 Cul2 Psma1 Eloc Elob Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Ube2d3 Psmd6 Psmd8 Ube2d1 Psmd2 Rpl4 Rps14 Rps15 Psmd1 Rpl5 Rps16 Adrm1 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Ltn1 Rps13 Trip4 Pelo Rpl7 Ascc3 Ascc2 Hbs1l Nemf Rpl30 Zfp598 LOC134486107 Klhdc10 Rpl31 Tcf25 Rpl32 Rchy1 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rps27a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubb Ubc Fau Rbx1 Rpl23a Psmb6l1 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 97%10228820 Activation of BH3-only proteins Dynll1 Mapk8 Dynll2 Ppp3cc Ywhaq Ywhah Ywhab Pmaip1 Sfn Bmf Ywhae Ppp3r1 Ywhag Ywhaz Bad Bcl2l11 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-RNO-5358493.1 Synthesis of diphthamide-EEF2 Dph5 Dph6 Eef2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nos3 Akt1 Prkg2 Spr Gch1 Calm3 Pts Hsp90aa1 Gchfr TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%10230244 Transferrin endocytosis and recycling Steap3 Atp6v0b Atp6v0a4 Mcoln1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Tf Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Hfe Steap4 Tfr2 Tfrc RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines Prmt3 Actl6b Ccnd1 Hist1h4m Cdk4 Prmt5 Rbbp7 H2ac18 Hist1h2ai Pbrm1 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Arid1a Prmt1 Arid1b Rps2 Wdr5 Actl6a Smarce1 Wdr77 Smarcc1 Smarca2 Carm1 H2ac4 Smarca4 H2bc18 Coprs H2ac25 Prmt6 Prmt7 Dnmt3a SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230654 Scavenging by Class H Receptors Sparc Stab1 Apob REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%10228866 Regulation of mitotic cell cycle Skp2 Aurka Fbxo5 Cdc14a Rb1 Pttg1 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cdk2 Psmb2 Ccnb1 Psma7 Plk1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Nek2l1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Aurkb Anapc1 Anapc2 Btrc Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9840310.1 Glycosphingolipid catabolism Glb1l3 Glb1l2 Ctsa Hexa Hexb Arsa Smpd2 Smpd3 Smpd4 Smpd1 Gba1 Gba3 Gba2 Enpp7 Neu2 Galc Asah2 Glb1 Neu3 Asah1 Neu4 Sts Gm2a Neu1 Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 M6pr Psap Glb1l HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229880 Histamine receptors Hrh2 Hrh3 Hrh1 Hrh4 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-RNO-9954714.1 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl4 Rps14 Rpl13 Rps15 Rpl14 Rpl5 Rps16 Rpl15 Rpl3 Rps17 Rps18 Rpl17 Rps19 Rpl18 Rpl19 Rpl35 Rpl36 Rpsa Uba52 Rpl10 Rpl37 Rpl38 Rpl11 Rps10 Rpl39 Rpl8 Rpl12 Rps11 Rps3 Rpl9 Rps2 Rpl10a Rpl6 Rps13 Rps4x Pelo Rpl7 Hbs1l Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 LOC134480579 Rps8 Rps5 Rps6 Rpl24 Ubc Rpl26 Fau Rpl23a Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-RNO-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes Tbl1x Rb1 Kmt2a Kmt2c H2ac18 Ajuba Crebbp Sirt1 Hdac3 Hist1h2bq Men1 Tbl1xr1 Wdr5 Ash2l Ncoa2 Med23 Med24 Med20 Tasp1 Akap8l Phf20 Ncor2 Cxxc1 Kat8 Paxip1 Med27 H2aj Ep300 Med12 Gps2 Med1 Yeats2 H3-3b Med13 Med14 Hist3h2ba Ncoa3 Wdr82 Kat2b Med10 Med4 Pparg Med6 Kat14 Mbip Hcfc1 H2bc18 Med16 Med17 Hcfc2 Dr1 Kansl3 H2az2 Ccnc Kansl1 Kansl2 Phf20l1 H2bc6 Setd1b Rbbp5 Bod1l1 Setd1a H2bc4 Pagr1 Hist1h4m Tada3 H2bc1 Med30 Abl1 Tada2a Med31 Ppargc1a Ppargc1b Kat2a Kmt2d Mcrs1 Hist1h2ai Zzz3 Kmt2b Sgf29 Psip1 Ogt Cdk5 H2ab2 H2ac4 Rxra ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding Dlg1 Calm3 Grik5 Grik2 Dlg3 Grik1 Grik4 Dlg4 Grik3 Ncald BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%10230168 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bcl2l1 Bid Bad Pmaip1 Bcl2l11 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport Lman2 Gorasp1 Tfg Gria1 Rab1b Sec23ip Sec16b Sec16a Napa Trappc2l Ctsc Ppp6r3 Gosr2 Cnih1 Lman1l Trappc10 Sec24d Sec24c Sec24b Cnih3 Ctsz Sec24a Cnih2 Tgfa Col7a1 Trappc9 Ppp6c Stx17 Sar1b Trappc5 Trappc4 Tmed10 Trappc3 Trappc2 Trappc1 Sec13 Csnk1d Tmed2 Trappc6b Serpina1 Trappc6a Sec31b Areg Sec31a F8 Rab1A Mcfd2 Ankrd28 Tbc1d20 Cd59 Folr1 Sec22a Golga2 Bet1 Scfd1 Nsf Uso1 Napb Stx5 Napg Ykt6 Sec23a Preb Lman2l Lman1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231152 Regulation of the apoptosome activity Cycsl2 Diablol1 Mapk1 Casp9 Apaf1 Xiap Apip Mapk3 Cycs ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%10230466 Acyl chain remodelling of PE Pla2g6 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g4b Pla2g12a Lpcat3 Lpcat4 Pla2g10 Abhd4 Plaat3 Pnpla8 Pla2g5 Plaat1 Pla2g3 Plaat5 Mboat1 Mboat2 Pla2g4a SELENOCYSTEINE SYNTHESIS%REACTOME%R-RNO-2408557.1 Selenocysteine synthesis Sephs2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%10229340 Gap junction degradation Dnm2 Gja1 Clta Cltb Dab2 Myo6 Cltc Ap2m1 Dnm1 PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events Pde3b AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 97%10231544 Amino acids regulate mTORC1 Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Atp6v0c Lamtor5 Rptor Lamtor3 Atp6v1e2 Rraga Atp6v1e1 Lamtor4 Tcirg1 RragB Atp6v1a Lamtor1 Atp6v1b2 Atp6v0d2 Rragc Lamtor2 Atp6v0d1 Atp6v1b1 Rragd Atp6v0e1 Atp6v1g2 Mtor Atp6v1g1 Atp6v1f Rheb Atp6v1d Mlst8 Slc38a9 Sec13 Mios Depdc5 Fnip1 Fnip2 Samtor Szt2 Castor2 Castor1 Sesn2 Sesn1 Kics2 Itfg2 Wdr24 Nprl3 Nprl2 Flcn Wdr59 Sh3bp4 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230980 Fructose biosynthesis Sord Akr1b1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 97%10230806 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Hmga1 Tp53 Rb1 Lmnb1 Ep400 H1-1 H1-0 Asf1a H1-5 Cabin1 H1-4 Hira H4f3 Ubn1 Hmga2 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress Chek1 Cdc25c Cdc25a Rad9a Rad9b Clspn Rad17 Rad1 Mcm7 Mcm8 Dbf4 Orc5 Atr Orc4 Orc6 Orc1 Orc3 Orc2 Rpa1 Rpa2 Cdc7 Cdc6 Rpa3 Cdk2 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Hus1 Rfc5 Atrip Rfc3 Rfc4 Rfc2 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%10231280 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Tfap2a Npm1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling Fgf18 Fgf2 Fgf23 Fgf4 Fgfrl1 Spred1 Spred2 Fgf5 Fgf8 Fgf10 Fgf3 Fgf22 Fgf17 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%10229966 RHO GTPases Activate ROCKs Rock2 Rock1 Rhoc Rhob Rhoa IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%10230594 IRF3 mediated activation of type 1 IFN Irf3 PLASMA LIPOPROTEIN REMODELING%REACTOME DATABASE ID RELEASE 97%10229234 Plasma lipoprotein remodeling P4hb Angptl8 Lmf1 Lmf2 Lpl Angptl4 Angptl3 Mttp Apoc2 Lcat Lipg Lipc Apoc3 Apoa2 Apoe Apoa4 Pcsk5 Apoa5 Furin Apob Pcsk6 Pltp Apoa1 Alb Gpihbp1 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 97%10231432 Biosynthesis of DHA-derived SPMs Hpgd Alox5 Lta4h Alox15 Gstm4 Cyp2c66 Cyp2c11 Cyp2e1 Cyp1a1 Ephx2 Cyp3a9 Cyp1a2 Ltc4s Ptgs2 Cyp3a18 Cyp3a1 Cyp3a62 Cyp2d4 Cyp3a2 Alox12 Gpx4 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229996 Cation-coupled Chloride cotransporters Slc12a2 Slc12a3 Slc12a6 Slc12a7 Slc12a1 Slc12a4 Slc12a5 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%10229962 Surfactant metabolism Gata6 Zdhhc2 Ckap4 Adra2a P2ry2 Adra2c Ctsh Adora2b Slc34a1 Adora2a Adgrf5 Dmbt1 Slc34a2 Abca3 Sftpa1 Ttf1 Lmcd1 Sftpb Napsa Sftpd Ccdc59 Sftpc PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375276.1 Peptide ligand-binding receptors Ccl20 Ccl21 F2rl1 Fpr2l1 Prokr2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Cxcr4 Cxcr5 Oprl1 Uts2 Mc5r Prlh Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Cxcl10 C5ar2 C5ar1 Aplnr Bdkrb2 Pdyn Bdkrb1 Nts Kng1 Tac3 Tac1 Oprm1 Pmch Ccrl2 Gper1 Pyy Rln3 Ednrb Ednra F2r Rln1 Cxcl16 Npff Cxcl13 F2 Pomc F2rl2 F2rl3 Apln Prlhr Trhr Oxt Ece1 Ece2 Oprd1 Trh Npy5r C3ar1 Galr2 Galr3 Galr1 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Npy4r Avpr1a Cx3cr1 Rxfp1 Qrfpr Insl3 Psap Ppbp Fpr1 Xcl1 Nmbr Fpr2 Ccr10 Kiss1 C3 Nln Avpr2 C5 Ccl9 Pnoc Cxcl9 Ccl7 Ppy Ccl6 Ccl5 Nmb Ccl4 Oxtr Ccl3 Hcrtr2 Xcr1 Hcrtr1 Ccl1 Grpr Cxcl1 Cxcl2 Nms Cxcl3 Nmu Cxcl5 Uts2b Cckar Npbwr1 Gpr37l1 Ackr3 Nmur2 Ackr4 Cck Nmur1 Ackr2 Ntsr2 Ntsr1 Uts2r Sst Oprk1 Brs3 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 App Ccr3 Edn1 Edn2 Edn3 Cckbr Agtr2 Avp Gpr37 Mc1r Gal Penk Agtr1 Hcrt Npb Grp Kiss1r Ccl19 Ccl17 Nps Mc4r Ccl11 Ccl12 Npw Npffr1 Npy Npffr2 Pf4 Cx3cl1 Fpr2l3 Prok2 Qrfprl Tacr1 Qrfp Ccl27 Agt Npsr1 Prok1 Mc3r SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-RNO-2142712.1 Synthesis of 12-eicosatetraenoic acid derivatives Gpx2 Aloxe3 Alox15 Gpx1 Alox12b Alox12 Gpx4 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-RNO-975634.1 Retinoid metabolism and transport Rdh11 Akr1b10 Lrp1 Sdc4 Sdc3 Lrp8 Lrp10 Plb1 Lrp12 Ttr Lpl Gpc1 Gpc3 Gpc2 Bco2 Gpc4 Apoc2 Bco1 Akr1c3l1 Gpc6 Agrn Clps Apoc3 Pnlip Sdc1 Apoa2 Sdc2 Lrp2 Rbp4 Apoe Apom Apoa4 Rbp2 Rbp1 Lrat Apob Akr1c18 Akr1c19 Akr1c1 Akr1c21 Akr1c9 Apoa1 Akr1c12l1 Gpc5 Akr1c12 Gpihbp1 Akr1c13 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 97%10231124 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Btg2 Cnot1 Cdc25c Cnot7 Plk2 Npm1 Cnot6 Cnot11 Tnks1bp1 Cnot4 Cnot9 Cnot8 Cnot6l Cnot10 Cpap Cnot3 Cnot2 Plk3 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%10230144 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Exosc3 Exosc2 Dcp2 Ywhab Dcp1a Zfp36l1 Xrn1 Akt1 Dis3 Mapkapk2 Exosc9 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-RNO-9609736.1 Assembly and cell surface presentation of NMDA receptors Grin2a Grin3a Grin2b Grin2d Grin2c Grin1 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-RNO-9616222.1 Transcriptional regulation of granulopoiesis Cebpa Cdk4 Rxra Cdk2 Rara EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%10228888 Eukaryotic Translation Elongation Eef1d Eef1a1 Eef2 Eef1b2 Eef1g TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification Arfgap3 Copa Dynll1 Arfgap2 Dynll2 Arfgap1 Gorasp1 Copb2 Gria1 Rab1b Arf1 Copb1 Cope Dync1li2 Dync1li1 Napa Golgb1 Bet1l Gosr1 Cnih1 Gosr2 Lman1l Sec24d Sec24c Cnih3 Sec24b Cnih2 Sec24a Col7a1 Trappc9 Ppp6c Sar1b Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Csnk1d Serpina1 Rab1A Mcfd2 Folr1 Spta1 Bet1 Ins1 Scfd1 Ins2 Sptbn1 Sptb Sptbn2 Sptan1 Sptbn5 Sptbn4 Cog1 Cog2 Cog3 St8sia2 Chst10 Cog4 Mgat5 Preb Mgat2 Mgat1 Cog5 Mgat3 Cog6 Cog7 St6gal1 Cog8 Manea B4galt4 Man1c1 B4galt5 Lman1 B4galt6 Fut8 Fuca1 Actr1a Man1a2 Lman2 Man1a1 St8sia6 Ank1 Man2a1 Man2a2 Mgat4c St3gal4 Mgat4a Mgat4b St8sia3 Dctn1 Tfg Dctn2 Tmem115 Dctn4 B4galt2 B4galt3 Sec23ip Sec16b Sec16a Trappc2l Ctsc Kdelr2 Kdelr3 Ppp6r3 Trappc10 Mia2 Mia3 Dync1h1 Tmed9 Ctsz Tgfa Kdelr1 Dync1i2 Dync1i1 Arf4 Arf3 Stx17 Tmed10 Sec13 Gbf1 Tmed2 Trappc6b Tmed3 Trappc6a Copg1 Copg2 Sec31b Areg Sec31a Tmed7 F8 Ankrd28 Tbc1d20 Copz2 Cd59 Cd55 Copz1 Arf5 Sec22a Golga2 Nsf Uso1 Napb Actr10 Stx5 Napg Ykt6 Sec23a Arcn1 Lman2l EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%10230808 EPHB-mediated forward signaling Actr2 Actb Actr3 Arpc1b Arpc1a Arhgef28 Kalrn Rasa1 Sdc2 Itsn1 Rac1 Grin1 Actg1 Cdc42 Rock2 Rock1 Arpc3 Grin2b Arpc2 Lyn Yes1 Ptk2 Src Rhoa Arpc5 Fyn Arpc4 Pak1 Hras Tiam1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229352 Transport of connexons to the plasma membrane Gjb2 Gja1 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 97%10230372 Erythrocytes take up oxygen and release carbon dioxide Aqp1 Ca1 Ca2 Ca4 Hba1 Hbb Rhag Slc4a1 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-RNO-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK Mapk7 Cckbr Mmp3 Rps6ka1 Mapk1 Rps6ka2 Hbegf Mapk3 Egfr Prkca Nras Gast Grb2 Kras Sos1 Hras Rps6ka3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 97%10229716 Platelet Aggregation (Plug Formation) Itgb3 Bcar1 Adra2a Adra2c Adra2b Ptpn1 Akt1 Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rapgef4 Rapgef3 Shc1 Pdpk1 Rasgrp1 Rasgrp2 Tln1 Rap1a Syk Ptk2 Src Grb2 Csk Sos1 Crk HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation Blvrb Abcg2 Hmox1 Hmox2 Blvra Ugt1a1 Abcc1 Abcc2 Slco1b2 Alb Slco2b1 Ugt1a2 Ugt1a3 Ugt1a5 Fabp1 Gsta5 SPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9845614.1 Sphingolipid catabolism Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Aldh3a2 Acer3 Plpp2 Sgpp2 Plpp3 Plpp1 Sgpp1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231554 Drug-mediated inhibition of ERBB2 signaling Erbb2 Cdc37 Hsp90aa1 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 97%10231588 Sensory perception of sweet, bitter, and umami (glutamate) taste Tas1r3 Gnat3 Tas2r38 Tas2r4 Tas2r3 Tas2r40 Tas2r7 Tas2r16 Gnb1 Tas2r13 Tas2r41 Gnb3 Tas2r136 Itpr3 Tas2r140 Tas2r105 Tas2r119 Tas2r107 Tas1r2 Tas2r120 Tas1r1 Tas2r39 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 Kl Gab1 Fgf10 Frs2 Fgf3 Frs3 Fgf22 Shc1 Fgf17 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Pik3ca Pik3r1 Nras Flrt1 Grb2 Flrt3 Flrt2 Kras Sos1 Fgfr1 Hras Ptpn11 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-RNO-6785631.1 ERBB2 Regulates Cell Motility Hbegf Btc Egfr Rhoa Erbb2 Ereg Egf Diaph1 Erbb3 Nrg2 Nrg1 Nrg3 Memo1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181430.1 Norepinephrine Neurotransmitter Release Cycle Syt1 Maoa Vamp2 Stxbp1 Slc18a2 Unc13b Cplx1 Rims1 Stx1a Rab3a Slc22a2 Ppfia3 Snap25 Slc22a1 Tspoap1 Ppfia2 Ppfia4 Ppfia1 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-RNO-427601.1 Inorganic anion exchange by SLC26 transporters Slc26a9 Slc26a11 Slc26a7 Slc26a2 Slc26a1 Slc26a6 Slc26a4 Slc26a3 TGFBR3 PTM REGULATION%REACTOME DATABASE ID RELEASE 97%10231666 TGFBR3 PTM regulation Psen2 Ncstn Mmp14 Aph1a Tgfbr3 Aph1b Mmp16 Timp1 Psenen Timp2 Psen1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230484 Transcriptional activation of mitochondrial biogenesis Cycsl2 Acss2 Idh2 Sirt5 Glud1 Sirt3 Sod2 Cycs Gabpa KETONE BODY CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228404 Ketone body catabolism Acat1 Oxct2a Bdh1 Oxct1 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 97%10231264 Transcriptional regulation by RUNX1 Ccnh Ccnd1 Cdk7 Kmt2a Kmt2c H2ac18 Psma4 Esr1 Psma3 Psma6 Pbrm1 Smarcd1 Psma5 Smarcb1 Crebbp Psma2 Smarcd3 Psma1 Smarcd2 Csnk2a2 Csnk2a1 Psmd12 Psmd11 Arid1a Arid1b Hist1h2bq Prmt1 Psmd14 Psmd13 Wdr5 Ash2l Actl6a Psmb5 Psmb4 Csnk2b Smarce1 Psmb7 Psmb6 Smarcc1 Psmb1 Smarca2 Psmb3 Psmb2 H2aj Ep300 Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Kat2b Psmc1 Psmc4 Psmc3 H2bc18 Foxp3 Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp5 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Hist1h2ai Prmt6 Actl6b Hdac1 Elf1 Cbfb Runx1 Itch Setd1b Setd1a Rps27a Abl1 Kmt2d Lmo2 Kmt2b Lmo3 Serpinb13 Zfpm1 Gata1 Gata2 Uba52 Ring1 Tp73 Ccnd2 Phc2 Cbx6 Ccnd3 Phc1 Cbx4 Cbx2 Phc3 Cdk6 Tcf3 Sin3a Sin3b Bmi1 Yaf2 Pax5 Elf2 Tal1 Yap1 Rnf2 Pcgf5 Tcf12 Pml H2ab2 Ctsk Ubb Ctsl Mnat1 H2ac4 Ubc Smarca4 Ptpn11 Gata3 Psmb6l1 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 Mpg Tdg Nthl1 Ogg1 Ung Mutyh Apex1 Mbd4 Smug1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%10229154 Plasma lipoprotein clearance Npc1 Pcsk9 Apoc4 Vldlr Hdlbp Cubn Ldlrap1 Rps27a Ap2b1 Ldlr Lipc Uba52 Clta Apoe Cltc Apob Apoa1 Ubb Nr1h3 Ap2a2 Ubc Ap2s1 Nr1h2 Ap2a1 Nceh1 Apobr Amn Soat2 Apoc1 Ap2m1 Soat1 Lipa Mylip Scarb1 Npc2 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-8868773.1 rRNA processing in the nucleus and cytosol Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Csnk1d Rps18 Rps19 Las1l Ltv1 Rpl35 Fcf1 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rrp9 Rpl6 Rps13 Pwp2 Rpl7 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Imp4 Rpl27 Rpl28 Rpp25 Rpl29 Rpl12-ps1 Ncl Rpl22 Xrn2 Rpl23 Snu13 Wdr75 Senp3 Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Pdcd11 Pno1 Rpl27a Rpl31l15 Rps20 Utp20 Rps21 Nop14 Rps23 Pelp1 Rps24 Rcl1 Utp25 Tbl3 Nol11 Rpp40 LOC100910714 Rps15a LOC102551819 Wdr3 Bud23 Dcaf13 Rps4x-ps13 Utp15 LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Rps3a Utp18 Wdr43 Rps27l Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Ddx49 Rpl35al8 Rps26-ps13 Wdr36 Rpl22l1 Ddx47 Rplp0 Rplp1 Rpl13a Rpl35al2 Csnk1e Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Nol9 Mphosph6 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Uba52 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rps3 Rps2 Rpl10a Exosc9 Rps4x Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Wdr18 Tsr1 Ubc Ddx21 Fau Rpl23a Wdr12 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231424 Biosynthesis of E-series 18(S)-resolvins Hpgd Alox5 Lta4h Alox15 Gpx4 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%10228128 Assembly of the pre-replicative complex Kpnb1 Kpna6 Kpna1 H2ac18 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Mcm7 Mcm8 Psmd12 Psmd11 Orc5 Hist1h2bq Orc4 Psmd14 Orc6 Psmd13 Orc1 Orc3 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Psmb7 Psmb6 Cdc6 Psmb1 Psmb3 Psmb2 Mcm3 Mcm4 H2aj Mcm5 Psma7 Mcm2 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Psmd7 Psmd6 H2az2 Psmd8 Ube2d1 Psmd2 H2bc6 H2bc4 Hist1h4m H2bc1 Rps27a Psmd1 Adrm1 Hist1h2ai Uba52 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 H2ab2 Ubb H2ac4 Ubc Psmb6l1 INTESTINAL ABSORPTION%REACTOME%R-RNO-8963676.1 Intestinal absorption Npc1l1 Slc2a2 Slc5a1 Slc2a5 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 97%10228478 mRNA Editing: A to I Conversion Adarb1 Adar COX REACTIONS%REACTOME%R-RNO-140180.1 COX reactions Ptgs1 ESR-MEDIATED SIGNALING%REACTOME%R-RNO-8939211.1 ESR-mediated signaling Tbp Gtf2a1 Greb1 Gtf2a2 Cited1 H2ac18 Strn Prkcz Cav2 Egfr Esr1 Esr2 Cdk9 Crebbp Igf1r Pou2f1 Xpo1 Pdpk1 Hist1h2bq Prmt1 Foxo3 Mmp7 Mmp3 Zdhhc21 Fkbp4 Fkbp5 Ptges3 Sphk1 Carm1 H2aj Ep300 Src H3-3b Zfp217 Foxa1 Egf Hist3h2ba Ncoa3 Kat2b Yy1 Cdkn1b H2bc18 Nr5a2 H2az2 H2bc6 H2bc4 Hist1h4m H2bc1 Gnai2 Gnai1 Hist1h2ai Gnai3 Calm3 S1pr3 Gnat3 Ptk2 Ereg Nras Nos3 Kras Hras Mmp2 Mmp9 Btc Akt3 Hdac1 Akt2 Kdm1a Akt1 Pik3r1 Pik3r2 Pik3r3 Kat5 Tgfa Cbfb Runx1 Atf2 Mapk1 Hbegf Mapk3 Areg Cav1 Fos Shc1 Ppp5c Nrip1 Kdm4b Hsp90aa1 Pik3ca Polr2c Polr2a Ppid Polr2b Uhmk1 Polr2g H2ab2 Polr2h Polr2e Ppidl1 Polr2f Tle3 Polr2i H2ac4 Polr2j Hsp90ab1 Zdhhc7 Jun Gtf2f2 Pgr Gtf2f1 Gata3 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 97%10230840 SUMOylation of immune response proteins Ube2i Nfkbia Sumo1 Ikbkg Rela Pias3 Pias4 Sumo2 Nfkb2 Ikbke FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%10228744 Formation of the Early Elongation Complex Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Nelfa Nelfb Nelfe Ctdp1 Ncbp2 Ncbp1 Supt4h1 Nelfcd Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%10231444 Biosynthesis of maresins Alox5 Cyp3a18 Cyp3a1 Cyp3a62 Cyp2c66 Cyp2d4 Cyp3a2 Cyp2c11 Cyp2e1 Ephx2 Cyp3a9 Cyp1a2 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-RNO-9909615.1 Regulation of PD-L1(CD274) Post-translational modification Prkag1 Prkag2 Ost4 Cops5 Ccnd1 Tmem258b Tusc3 Cdk4 Cul1 Cul3 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 B3gnt3 Csnk2a2 Dad1 Csnk2a1 Ywhag Psmd12 Psmd11 Psmd14 Psmd13 Ddost Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Cd274 Os9 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Pdcd1 Rnf5 Sel1l Nek2l1 Magt1 Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Mib2 Psmd1 Pdcd1lg2 Adrm1 Prkab2 Prkab1 Skp1 Uba52 Btrc Rnf185 Prkaa1 Derl3 Ubb Derl2 Ubc Stt3b Rbx1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Psmb6l1 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231398 RHOG GTPase cycle Arfgap3 Elmo2 Kalrn Rhog Arhgdib Garre1 Iqgap2 Cyfip1 Shmt2 Itsn1 Arhgdig Lbr Diaph3 Vav3 Cdc42ep1 Pgrmc2 Dock5 Cdc42 Dock3 Dock4 Dsg2 Arhgap21 Letm1 Vav2 Mcam Ophn1 Rab7a Stbd1 Arhgdia Pld1 Emd Vav1 Dock2 Vapb Arhgap32 Lamtor1 Pik3r1 Pak4 Ndufs3 Esyt1 Plekhg3 Mpp7 Ankle2 Vrk2 Map3k11 Hspe1 Tfrc Mcf2l Pak2 Arhgef16 Ndufa5 Arhgef26 Arhgef5 Vamp3 Arhgap35 Depdc1b Cav1 Epha2 Prex1 Itgb1 Trio Ktn1 Arhgap5 Mcf2 Arhgap1 Stx5 Ykt6 Lman1 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231394 CDC42 GTPase cycle Arhgdib Itsn1 Arhgdig Lbr Vav3 Cdc42 Arhgap21 Vav2 Ophn1 Arhgdia Arhgap32 Pik3r1 Pik3r2 Ngef Plekhg3 Spata13 Srgap1 Srgap2 Srgap3 Arhgap45 Gmip AABR07032856.1 Arhgap10 Mcf2l Arhgap17 Bcr Dock6 Arhgef15 Arhgap4 Fam13b Arhgef16 Dock7 Arhgef11 Dock8 Arhgef10 Arap1 Arhgef12 Arap3 Arhgef19 Arap2 Arhgap22 Arhgef26 Arhgap9 Arhgef25 Arhgap20 Syde1 Arhgef6 Arhgap26 Arhgef5 Arhgap24 Arhgef4 Arhgap29 Racgap1 Gna13 Arhgap27 Def6 Myo9b Fgd2 Arhgap33 Arhgef9 Arhgap31 Fgd1 Arhgap30 Arhgap35 Fgd4 Dnmbp Depdc1b Prex2 Abr Tagap Cav1 Fgd3 Dock10 Dock11 Plekhg1 Farp1 Ect2 Ralbp1 Prex1 Stard8 Trio Dlc1 Ktn1 Stard13 Arhgap5 Mcf2 Arhgap40 Arhgap44 Plekhg2 Arhgap42 Arhgap1 Rasgrf2 Ykt6 Tiam1 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231392 RAC1 GTPase cycle Nckap1 Wasf3 Wasf2 Wasf1 Abi2 Cyba Abi1 Cybb Cyfip2 Arhgdib Garre1 Cyfip1 Rac1 Lbr Diaph3 Cdc42ep1 Vav3 Dock5 Dock3 Dock4 Als2 Arhgap21 Mcam Vav2 Ophn1 Pld1 Arhgdia Dock2 Arhgap32 Lamtor1 Pak4 Esyt1 Ngef Plekhg3 Mpp7 Spata13 Pak1 Srgap1 Srgap2 Srgap3 Arhgap45 Gmip AABR07032856.1 Tfrc Arhgap10 Mcf2l Arhgap17 Tiam2 Bcr Pak2 Dock6 Arhgap4 Arhgef15 Fam13b Dock7 Arhgef11 Dock8 Arap1 Arhgef10 Arap3 Arap2 Arhgef19 Arhgap22 Arhgap9 Arhgef25 Arhgap20 Arhgef6 Arhgef5 Arhgap26 Arhgef4 Arhgap24 Arhgap29 Gna13 Arhgap27 Def6 Myo9b Arhgap33 Arhgap31 Arhgap30 Prex2 Abr Tagap Dock10 Fermt2 Arhgef39 Dock11 Plekhg1 Farp1 Ect2 Ralbp1 Prex1 Trio Itgb1 Dlc1 Mcf2 Arhgap44 Plekhg2 Arhgap42 Cdc42bpa Cdc42ep4 Rasgrf2 Syde2 Pld2 Abl2 Slc1a5 Jag1 Nox3 Nox1 Swap70 Amigo2 Noxa1 Arhgap15 Arhgap12 Cit Fam13a Baiap2l1 Arhgap25 Arhgap23 Fgd5 Sos1 Pak6 Pak5 Fmnl1 Git2 Noxo1 Taok3 Chn2 Tiam1 Plekhg6 Farp2 Sh3bp1 Pkn2 Git1 Pkn1 Kalrn Arhgef7 Iqgap2 Iqgap3 Pak3 Cdc42 Rab7a Emd Vav1 Pik3r1 Pik3r2 Pik3r3 Vrk2 Snap23 Pard6a Racgap1 Nisch Vamp3 Arhgap35 Depdc1b Cav1 Epha2 Ktn1 Arhgap5 Arhgap1 Pik3ca Ykt6 Ncf1 Ncf2 Sos2 Ncf4 Brk1 Baiap2 Nckap1l POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels Kcnh8 Kcnd3 Kcnh7 Kcnd2 Kcnh6 Kcnd1 Kcnh5 Kcnh4 Kcnh3 Kcnh2 Kcnq5 Kcnq1 Kcna7 Kcnmb1 Kcna6 Kcnmb2 Kcna5 Kcna4 Kcna3 Kcnj3 Kcna10 Kcnj2 Kcna2 Kcna1 Kcnmb3 Kcnmb4 Kcnj1 Kcnn4 Kcnn3 Kcnk13 Abcc8 Kcnn2 Kcnn1 Kcnk10 Kcnk16 Kcnv2 Kcnk18 Kcnv1 Hcn3 Hcn4 Kcnma1 Kcnb2 Gabbr1 Kcnb1 Kcnj8 Kcnf1 Kcnk4 Gabbr2 Kcnk2 Kcnk1 Kcnab1 Kcns3 Kcnab2 Kcns2 Kcns1 Kcnj9 Kcnab3 Kcnj6 Kcnc4 Kcnj5 Kcnc3 Gng10-ps1 Kcnj4 Kcnc2 Kcnk9 Kcnc1 Kcng4 Kcnk7 Kcng3 Kcng2 Kcnj10 Kcnk6 Kcnj12 Kcng1 Kcnh1 Kcnj14 Kcnj15 Kcnj16 Hcn1 Hcn2 Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Abcc9 Gng11 Gng12 Kcnj11 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228164 Leading Strand Synthesis Pold3 Prim2 Pold1 Prim1 Pold4 Pola2 Rfc5 Pola1 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death Chmp2b Dynll1 Dynll2 Bcl2l1 Hmgb1l2 Hmgb1l1 Kpnb1 Prkcq Kpna1 Fnta Lmna Casp6 Lmnb1 Cd14 Ywhae Ywhag Chmp3 Chmp7 Ctnnb1 Chmp6 Dsg2 Apc Flot2 Flot1 Bcl2l11 Prkcd Bax Ripk3 Bid Fadd Ripk1 Chmp4c Bad Ppp3cc Ywhaq Ywhah Ptk2 Ywhab Pmaip1 Sptan1 Sfn Bmf Casp7 Gsn Gas2 Vim Mapt Sh3glb2 Add1 Plec Sdcbp Gsdmd Cycsl2 Cdh1 Il18 Rock1 Cdc37 Itch Cycs Mapk8 Mapk1 Stk26 Peli1 Stk24 Il1a Prkn Pkp1 Rps27a Ube2l3 Il1b Mapk3 Mlkl Oma1 Ticam2 Ocln Hmgb2 Clspn Bmx Gsdme Dnm1l Traf2 Ticam1 Pdcd6ip Nmt1 Ppp3r1 Ogt Birc2 Opa1 Diablol1 Dsp Casp9 Uba52 Apaf1 Dcc Xiap Septin4 Elane Apip Dsg3 Gzmb Appl1 Tjp1 Bak1 Ly96 Acin1 Satb1 Stub1 Bcap31 Dffa Dffb Tjp2 Dsg1 Hsp90aa1 Tlr4 Hmgb1-ps34 Ubb Chmp4bl1 Ubc H1-1 H1-0 Ywhaz Casp8 H1-5 H1-4 Tradd Fas H4f3 Cflar Casp3 Faslg Chmp2a Tnfsf10 Casp1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 97%10228434 The canonical retinoid cycle in rods (twilight vision) Rdh11 Rdh10 Rdh12 Stra6 Rpe65 Rbp3 Myo7a Rlbp1 Cyp4v2 Rho Ttr Rbp4 Rbp1 Lrat CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis Srebf1 Lbr Cyp51a1 Plpp6 Fdps Idi1 Hsd17b7 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Acat2 Nsdhl Dhcr24 Dhcr7 Lss Srebf2 Tm7sf2 Pmvk Hmgcr Mvd Msmo1 NGF PROCESSING%REACTOME%R-RNO-167060.1 NGF processing Ngf Pcsk5 Furin Pcsk6 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 97%10229438 Formation of annular gap junctions Dnm2 Gja1 Clta Cltb Dab2 Cltc Ap2m1 Dnm1 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-RNO-983169.1 Class I MHC mediated antigen processing & presentation Lrr1 Nedd4 Psme2 Psme1 Rnf220 Cbll1 Psmb10 Fbxl21 Rnf213 Wsb1 Rnf217 Ube2d2 Cul3 Hecw2 Ccnf Psma4 Cblb Psma3 RT1-M6-2 Psma6 Sh3rf1 Trim11 Psma5 Vhl Ube2l6 Psma2 Mex3c Psma1 Cul2 Cdc34 Eloc B2m Elob Dcaf1 Rnf126 Rnf123 Cd207 Psmd12 Ubac1 Psmd11 Lnpep Atg7 Rnf114 Vamp8 Psmd14 Rnf115 Psmd13 Hace1 RT1-M10-ps5 Siah1 Siah2 Psmb5 Keap1 Psmb4 Dzip3 Mrc2 Psmb7 Mrc1 Psmb6 Mkrn1 Psmb1 Ube2g2 Calr Psmb3 Sec24d Ube2g1 Psmb2 Rnf138 RT1-N3 Sec24c Kbtbd7 Sec24b Rnf130 Kbtbd8 Psma7 Sec24a Fbxw4 Fbxw5 Psmc5 Fbxw7 Gan Psmc2 Fbxw8 Psmc1 Fbxw9 Psmc4 Cd36 Psmc3 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Psmd7 Psmb9 Psmd6 Ube2d3 Klhl3 Psmb8 Psmd8 Klhl2 Psmd2 Ube2d1 Rnf111 Ube4a Smurf2 Spsb2 Smurf1 Trim9 Spsb1 Trip12 RT1-M1-5 Spsb4 Mib2 Rt1-ec3 Psmd1 Lrsam1 Huwe1 Ube2j2 Adrm1 Ube2j1 Kctd7 Ube2u Kctd6 Ube2w Ube2m Ube2k Rnf182 Ube2o Pdia3 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Uba7 Trim69 Fbxw17 Trim71 Klhl25 Ube2e3 Ube2e2 Klhl21 Rnf19b Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Hspa5 Uba1 Uba3 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Snap23 Herc6 Itch Fcgr1a Fbxo9 Trim21 Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Rps27a Trim41 Unkl Erap1 Ube2n Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Asb1 Skp1 Vamp3 Lnx1 Uba52 Sec31a Fbxw11 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc5 Anapc4 Anapc1 Anapc2 Btrc Fzr1 Anapc7 Wwp1 Ube2e1 Cdc16 Ubb Ncf1 Ncf2 Ubc Ncf4 Itgav Mylip Cul1 Cyba Cybb Sar1b Ltn1 Rchy1 Skp2 Canx Ube2v2 Prkn Ube2l3 Sec13 Socs1 Socs3 Cdc20 Stub1 Herc2 Sec23a Rbx1 Psmb6l1 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%10231106 Formation of the cornified envelope Pkp1 Jup Cdsn Klk5 Dsp Kazn Klk8 Ppl Dsg3 Tgm1 Sprr3 Stfa2l3 Casp14 Evpl Cela2a Spink6 Spink5 Perp Klk12 Pkp2 Dsg2 Pkp3 Dsg1 Lipk Dsg4 Dsc1 Dsc2 Rptn Lipm Klk14 Klk13 Dsc3 Lipn MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229350 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 RHOT2 GTPASE CYCLE%REACTOME%R-RNO-9013419.1 RHOT2 GTPase cycle Mfn1 Mfn2 Trak1 Myo19 Trak2 Rhot2 GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism Pgam2 Pgam1 Slc37a4 Tpi1 Nup58 Slc37a2 Nup37 Slc37a1 Nup205 Hkdc1 Pom121 Fbp1 Fbp2 Gckr Nup107 Pklr Nup188 Gapdhs Aldoc Tpr Bpgm Nup160 Aldoa Pfkl Pgk1 Rae1 Ndc1 Pgk2 Pck1 Nup85 Pfkm Pfkp Nup42 Pck2 Pgm2l1 Nup62 Nup43 G6pc1 Pkml1 Nup88 Gck Aaas Hk2 Hk3 Nup214 Adpgk Ranbp2 G6pc3 Tpi1l2 Nup155 Nup133 Nup210 Nup153 Sec13 Aldob Gnpda1 Gpi Gnpda2 Eno3 Nup93 Eno2 Nup50 Eno4 Pfkfb4 Pfkfb3 Nup35 Pfkfb2 Pfkfb1 Nup54 Pc Nup98 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%10230368 O2 CO2 exchange in erythrocytes Cyb5r2 Aqp1 Cyb5r1 Cyb5rl Ca1 Ca2 Ca4 Hba1 Hbb Rhag Cyb5r4 Slc4a1 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling Ntrk3 Ntf3 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 97%10230374 Methionine salvage pathway Enoph1 Mtap Adi1 Mri1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230436 Mitochondrial iron-sulfur cluster biogenesis Fxn Fdxr Fdx2 Isca2 Glrx5 Hscb Isca1 Nfs1 Iscu Lyrm4 Fdx1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%10231472 Activated NTRK2 signals through FRS2 and FRS3 Grb2 Sos1 Ntf4 Ntrk2 Frs2 Bdnf BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229594 Basigin interactions Slc7a5 Cav1 Itgb1 Slc7a11 Itga6 L1cam Slc7a10 Mag Spn Slc3a2 Itga3 Ppil2 Slc16a3 Mmp1b Slc16a8 Ppia Slc7a6 Slc7a7 Atp1b1 Atp1b3 Atp1b2 Slc16a1 Slc7a8 Bsg Slc7a9 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains ENSRNOG00000065955 Trbv16 RT1-Da RT1-Db2 Cd247 Cd3g Csk RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Ptprc Lck Ptpn22 RT1-Ba RT1-Bb Pag1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%10229838 ICOS co-stimulation Pik3cg Pik3r3 Icos Pik3cb Pik3cd Pik3ca Icoslg Pik3r5 Pik3r1 Pik3r6 Pik3r2 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization Lrrk2 Gpnmb Hbegf Ptk6 Egfr Hif1a APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Skp2 Aurka Rb1 Pttg1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Plk1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Aurkb Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 97%10228356 Processing of Capped Intron-Containing Pre-mRNA Hspa8 Rnf113a1 Rbbp6 Rps27a Rbmx Uba52 Polr2c Ctnnbl1 Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ubb Polr2i Ubc Polr2j Nup93 Nup50 Snrpf Nup35 Gtf2f2 Gtf2f1 Nup54 Nup98 Snrpg Snrpb Nup58 Nup37 Nup205 Pom121 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Snrpd1 Nup85 Ncbp2 Nup42 Ncbp1 Nup62 Nup43 Nup88 Aaas Snrpd3 Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Snrpepl2 Ppil2 Eif4e Ppp1ca Snrnp200 Phf5a Rnps1 Fam50a Smndc1 Gle1 Pnn Fyttd1 Znf830 Hnrnpr-ps2 Prpf40a Rnf113a2 U2surp Crnkl1 Ddx39a Cdc40 Aqr Pcbp2 Prcc Pcbp1 Ddx39b Magoh Sympk Clp1 Upf3b Sarnp Tfip11 Hnrnpr Dhx8 Dhx9 Wdr70 Hnrnpu Snrpa1 Rbm10 Mettl3 Steep1 Dhx38 Dhx35 C3h9orf78 Ptbp1 Mettl14 Sugp1 Eif4a3 Zrsr2 Rnpc3 Hnrnpc Hnrnpd Hnrnpf Ppwd1 Hnrnpk Hnrnpl Pcf11 Cstf1 Gcfc2 Nudt21 Dhx16 Cstf2 Ccdc12 Dhx15 Cstf3 Slbp Srsf19 Srsf11 Srsf12 Srrm1 Rbm8a Sde2 Tut1 Slu7 Srrm2 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Ppp1cb Nkap Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Hnrnph2 Hnrnph1 Leng1 Prpf6 Mfap1al1 Zmat5 Cactin Ppig Ppie Thoc2 Thoc3 Thoc5 Hnrnpa2b1 Thoc6 Thoc7 Srrt Snrnp70 Rbmx2 Cwc22 Nsrp1 Cwc27 Cwc25 Zcrb1 Prpf8 Wbp11 Prpf19 Htatsf1 Prpf18 Snrnp40 Eftud2 Papolg Ppp1r8 Fip1l1 Snrnp48 Snip1 Papola Fam32a Snrpa Snrpc Snrpn Alyref Chtop Cwc15 Cherp Yju2 Fus Cpsf4 Cpsf6 Cpsf7 Rbm25l1 Cpsf1 Cpsf2 Gpatch1 Sec13 Cpsf3 Casc3 Magohb Pqbp1 Isy1 Nxt1 Prr3 Cdc5l Snrnp25 Ybx1 Dnajc8 Rbm25 Srsf1 Plrg1 Rbm5 Srsf9 Srsf7 Srsf5 Srsf3 Acin1 Srsf2 Rbm22 Snrnp35 Hnrnpa3 Rbm17 Syf2 Ddx46 Bud31 Ddx41 Ddx42 Puf60 Wtap Cwf19l2 Poldip3 U2af1 Ppil4 Ppil3 Nxf1 Hnrnpa1 Ppil1 Sap18 Cstf2t Nxf5 U2af1l4 Nxf7 Tcerg1 Tra2b Pabpn1 Bud13 Bcas2 Pdcd7 Ddx23 Gpkow L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression Eif4e Eif1ax Eif4a2 Eif4a1 Pabpc1 Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Rpl4 Eif3e Rps14 Eif3h Rps15 Eif3g Rpl5 Eif3b Rps16 Eif3a Rpl3 Eif3d Rps17 Eif3c Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10229634 MicroRNA (miRNA) biogenesis Ago3 Ago2 Ago1 Dicer1 Tarbp2 Ago4 Prkra OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Egln1 Egln2 Egln3 Epas1 Hif3a Ube2d2 Psma4 Wtip Psma3 Ajuba Psma6 Hif1a Psma5 Vhl Psma2 Limd1 Psma1 Cul2 Eloc Elob Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Ube2d3 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ubb Ubc Rbx1 Psmb6l1 PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Xdh Itpa Dnph1 Nt5c2 Nudt5 Pnp REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975578.1 Reactions specific to the complex N-glycan synthesis pathway Man2a1 Man2a2 Chst10 Mgat2 Fut8 Fuca1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 97%10231426 Biosynthesis of EPA-derived SPMs Hpgd Alox5 Lta4h Alox15 Ptgs2 Gpx4 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 97%10229862 Beta-oxidation of pristanoyl-CoA Acoxl Crot Scp2 Acox3 Crat Acox2 Amacr Acot8 Hsd17b4 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 97%10231460 Biosynthesis of DHA-derived sulfido conjugates Gstm4 Ltc4s CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%10230706 Ca2+ pathway Gnao1 Nlk Tcf7l2 Ppp3ca Map3k7 Fzd3 Ppp3cb Fzd6 Nfatc1 Lef1 Ppp3r1 Camk2a Gnat2 Calm3 Pde6a Gng3 Pde6b Gng5 Gng4 Ctnnb1 Gng7 Gng8 Gngt1 Fzd2 Wnt5a Fzd5 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Fzd4 Gng12 Kras Gng10-ps1 Wnt11 Pde6g MAP KINASE ACTIVATION%REACTOME%R-RNO-450294.1 MAP kinase activation Map2k3 Ppp2r1b Ppp2r1a Cul1 Tab3 Tab2 Tab1 Chuk Mapk10 Mapk11 Mapk9 Atf2 Ikbkb Atf1 Mapk7 Mapk8 Traf6 Mapk1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Nfkb1 Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Rps6ka3 Rps6ka5 Rps6ka1 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d Map2k7 Map2k6 Dusp3 Dusp4 Ubb Ripk2 Ubc Dusp7 Dusp6 Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 CS DS DEGRADATION%REACTOME%R-RNO-2024101.1 CS DS degradation Hyal1 Glb1l3 Gusb Glb1l2 Arsb Hexa Hexb Dcn Glb1 Idua Glb1l Ncan Bgn Bcan Cspg5 Cspg4 Vcan Hyal4 Hyal3 Ids ACTIVATION OF GABAB RECEPTORS%REACTOME%R-RNO-991365.1 Activation of GABAB receptors Adcy8 Adcy5 Kcnj15 Adcy6 Kcnj16 Adcy9 Gnai2 Gnai1 Gnai3 Kcnj3 Kcnj2 Gng3 Gnal Gng5 Gng4 Gng7 Gng8 Gngt1 Gnat3 Gnb2 Gnb1 Gabbr1 Gnb4 Gnb3 Gnb5 Gng11 Gabbr2 Gng12 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Kcnj10 Kcnj12 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-RNO-74751.1 Insulin receptor signalling cascade Akt2 Kl Gab1 Flt3 Fgf10 Trib3 Fgf3 Fgf22 Fgf7 Pdpk1 Grb10 Pik3c3 Them4 Pde3b Pik3r4 Gab2 Insr Pik3r1 Pik3r2 Fgfr3 Mapk1 Mapk3 Irs1 Irs2 Frs2 Shc1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Pik3cb Fgfr2 Ins1 Fgf6 Fgf5 Fgf8 Ins2 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Tlr9 Grb2 Sos1 Fgfr1 Ptpn11 FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling Fadd Casp8 Fas Faslg METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 97%10230670 Metabolism of ingested SeMet, Sec, MeSec into H2Se Mat1a Scly FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%10229456 Fcgamma receptor (FCGR) dependent phagocytosis Nckap1 Elmo2 Elmo1 Wasf3 Wasf2 ENSRNOG00000069193 Wasf1 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Abi2 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Abi1 ENSRNOG00000070415 Cyfip2 ENSRNOG00000070810 ENSRNOG00000066926 Cyfip1 ENSRNOG00000066406 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Vav3 ENSRNOG00000070192 Plcg1 Plpp4 Iglc1 Plpp5 Plcg2 Wipf3 ENSRNOG00000070159 ENSRNOG00000071049 Wipf1 Btk AABR07034736.1 Pld4 Vav2 ENSRNOG00000065564 Pld3 Arpc3 Myo5a ENSRNOG00000066971 Pld1 Fcgr2 ENSRNOG00000063341 Arpc2 Fgr ENSRNOG00000065283 Lyn Myh9 ENSRNOG00000062976 Yes1 Myo1c ENSRNOG00000063549 Nckipsd Src ENSRNOG00000063148 Limk1 Myo10 Igkvl13 AABR07065812.2 Arpc5 ENSRNOG00000063707 ENSRNOG00000067679 Arpc4 Cd3g Pak1 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Prkce ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Prkcd Myo9b Pld2 Ptk2 Grb2 Fyn Actr2 Actb Actr3 Arpc1b Arpc1a Actg1 Cdc42 Syk Vav1 Hck Pik3r1 Pik3r2 Fcgr1a Mapk1 Abl1 Mapk3 Pla2g6 Hsp90aa1 Pik3cb Pik3ca Hsp90ab1 Crk Brk1 Baiap2 Nck1 Nckap1l SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%10231212 Synaptic adhesion-like molecules Lrfn3 Lrfn4 Ptprf Lrfn1 Dlg1 Dlg3 Ptprs Dlg4 Grin2b Grin2a Gria1 Rtn3 Gria4 Flot2 Gria3 Flot1 Grin2d Grin2c Grin1 Lrfn2 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 97%10228228 Gluconeogenesis Pgam2 Pgam1 Slc37a4 Tpi1 Slc37a2 Slc37a1 Fbp1 Fbp2 Gapdhs Aldoc Aldoa Pgk1 Pgk2 Pck1 Pck2 Gpi G6pc1 Eno3 Eno2 Aldob Eno4 G6pc3 Tpi1l2 Pc VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-194313.1 VEGF ligand-receptor interactions Flt1 Pgf Flt4 Vegfa Vegfd Vegfc Kdr Vegfb BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 97%10231470 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Alox5 Ptgs2 SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG Cds2 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-RNO-350562.1 Regulation of ornithine decarboxylase (ODC) Psmd8 Psmd2 Psmd1 Azin1 Odc1 Adrm1 Psma4 Psma3 Psma6 Psma5 Nqo1 Psma2 Psma1 Psmd12 Psmd11 Oaz1 Oaz3 Psmd14 Oaz2 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling Il33 Il1rl1 Il1rap INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%10228338 Interconversion of nucleotide di- and triphosphates Glrx Ak4 Ak7 Ak6 Nme1 Ak9 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 Txnrd1 Rrm2b Txn Dtymk Nudt13 Dut Rrm1 Tyms Rrm2 Ak1 Gsr Nme3 Nme2 Ak2 Ak5 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-RNO-9959399.1 SLC-mediated transport of oligopeptides Slc15a1 Ctns Slc15a4 Slc15a3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling Irf7 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-RNO-166016.1 Toll Like Receptor 4 (TLR4) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Irf3 Ube2d2 Tab2 Usp18 Tab1 Nlrc5 Cd14 Ikbke Chuk Mapk10 Mapk11 Dnm1 Dnm3 Plcg2 Dnm2 Ube2d3 Ube2d1 Cd180 Tank Ly86 Traf3 Sarm1 Ripk3 Lbp Bpi Fadd Ripk1 Tirap Ptpn4 Tbk1 Optn Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Ecsit Skp1 Birc2 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Ptpn11 Mapk14 Jun Mapkapk2 Irak2 Irak1 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 97%10228788 Fibrin formation Itgb3 Fgb Fga Fgg F13a1 Itga2b F2 Proc Serpina5 Serpinc1 Serpine2 Serpind1 F13b MET ACTIVATES RAS SIGNALING%REACTOME%R-RNO-8851805.1 MET activates RAS signaling Ranbp10 Met Nras Grb2 Kras Sos1 Hras Shc1 Hgf Ranbp9 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion Apobec4 Apobec2 Apobec3 A1cf Apobec1 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 97%10228464 RHO GTPases activate PKNs Pkn2 Pkn1 Cdc25c H2bc6 H2bc4 Hist1h4m H2bc1 Rhoc Rhob H2ac18 Ppp1cb Hist1h2ai Kdm1a Ywhae Ywhag Pdpk1 Hist1h2bq Rac1 Ncoa2 Kdm4c Ppp1r12b Ppp1r14a Ar Ppp1r12a Ywhaq Ywhah Ywhab H2aj H2ab2 Rhoa Sfn H3-3b Hist3h2ba H2ac4 Ywhaz H2bc18 H2az2 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%10230660 ECM proteoglycans Itgb3 Dcn Acan Agrn Ncan Itga2b Bcan Vcan Itgb1 Itga7 Tnc Itgax Itga8 Dmp1 Itga9 Dspp Vtn Tnn Itga2 Tnr Tnxb Itgb6 Hapln1 Itgav Serpine1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%10230800 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Dkk4 Kremen2 Kremen1 Lrp6 Sost Dkk1 Dkk2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-194002.1 Glucocorticoid biosynthesis Hsd3b Cyp17a1 Hsd3b6 Serpina6 Hsd3b5 Hsd3b1 Hsd3b5-ps1 Hsd11b1 Hsd11b2 Cyp21 Cyp11b1 Cyp11b3 Cyp11b2 Pomc TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%10229540 TCF dependent signaling in response to WNT Ppp2r1b Ppp2r1a Csnk1a1 Cul3 Psma4 Psma3 Psma6 Psma5 Crebbp Psma2 Psma1 Csnk2a2 Csnk2a1 Psmd12 Psmd11 Xpo1 Lrp6 Ctnnb1 Psmd14 Psmd13 Ppp2r5b Dvl2 Wdr5 Ppp2r5a Dvl1 Ash2l Dvl3 Wnt1 Psmb5 Amer1 Psmb4 Fzd1 Csnk2b Fzd2 Psmb7 Fzd5 Psmb6 Psmb1 Ppp2r5e Apc Axin1 Psmb3 Psmb2 Wnt8b Gsk3b Wnt8a Frat2 Ep300 Frat1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Smurf2 Rbbp5 Psmd1 Adrm1 Cdc73 Dkk4 Kremen2 Kremen1 Sost Dkk1 Dkk2 Sox3 Sox9 Ctbp1 Sox7 Sox6 Hdac1 Pygo2 Akt2 Sox4 Tle1 Pygo1 Tle4 Akt1 Tle2 Tnks2 Hecw1 Klhl12 Axin2 Rnf43 Tcf7 Sox13 Tcf7l1 Sox17 Bcl9l Men1 Bcl9 LOC134484451 Rnf146 Cby1 Znrf3 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Dact1 Sry Leo1 Ryk Ctnnbip1 Fzd4 Lgr5 Lgr6 Pip5k1b Csnk1e Tcf7l2 Rps27a Fzd6 Fzd8 Kmt2b Lef1 Ppp2cb Ppp2ca Uba52 Cav1 Xiap Wnt5a Btrc Ppp2r5d Tle3 Ubb Ubc Smarca4 Rbx1 Ywhaz Psmb6l1 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%10230142 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Exosc3 Exosc2 Dcp2 Ywhab Dcp1a Xrn1 Zfp36 Tnpo1 Dis3 Mapkapk2 Exosc9 REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs Spred1 Spred2 Cul3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rasa1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Kbtbd7 Psma7 Psmc5 Rasal1 Psmc2 Rasal2 Psmc1 Rasal3 Psmc4 Syngap1 Psmc3 Spred3 Rasa2 Rasa4 Rasa3 Nf1 Dab2ip Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Nras Ubb Ubc Kras Rbx1 Hras Psmb6l1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-RNO-5357956.1 TNFR1-induced NF-kappa-B signaling pathway Otud1 Traf1 Spata2 Rnf31 Usp2 Usp4 Ikbkg Rack1 Cyld Otud7b Map3k7 Tab3 Tab2 Tab1 Traf2 Chuk Birc2 Optn Ripk1 Xiap Tnfrsf1a Rbck1 Tradd Sharpin Ikbkb Tnf Usp21 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230104 Interleukin-27 signaling Il6st Il27 Crlf1 Tyk2 Canx Jak2 Ebi3 Stat3 Stat1 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%10229814 PERK regulates gene expression Eif2s3 Eif2s2 Eif2s1 Eif2ak3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Akr1c18 Akr1c19 Ptges3 Cyp8b1 Akr1c1 Akr1c21 Akr1c9 Cbr1 Tbxas1 Hpgds Ptgs1 Ptgs2 Ptges Ptgds Akr1c12l1 Ptgis Ptges2 Akr1c3l1 Akr1c12 Akr1c13 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%10230092 Synthesis of UDP-N-acetyl-glucosamine Nagk Gnpnat1 Amdhd2 Uap1 Gfpt1 Gfpt2 Pgm3 Renbp P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins Itgb3 Bcar1 Rap1a Ptk2 Src Fn1 Apbb1ip Fgb Fga Rap1b Fgg Crk Itga2b Tln1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions Ppl Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Xdh SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-RNO-187577.1 SCF(Skp2)-mediated degradation of p27 p21 Psmd8 Psmd2 Skp2 Ccnd1 Cdk4 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Ccne1 Psmd12 Ccne2 Psmd11 Ccna1 Psmd14 Ccna2 Psmd13 Cks1b Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cdk2 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Ptk6 Cdkn1b Psmd7 Psmd6 Psmb6l1 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling Erbb2 Erbb3 Nrg2 Nrg1 Grb7 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-RNO-445717.1 Aquaporin-mediated transport Gnas Avp Avpr2 Prkaca Prkacb Aqp1 Prkar1a Prkar1b Gng3 Rab11a Gng5 Gng4 Gng7 Myo5b Gng8 Aqp9 Gngt1 Aqp8 Aqp7 Prkar2a Aqp11 Aqp5 Aqp4 Aqp3 Gnb2 Aqp2 Aqp12a Gnb1 Mip Gnb4 Aqp10 Gnb3 Gnb5 Gng11 Gng12 Gng10-ps1 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%10230464 Acyl chain remodelling of PS Mboat1 Osbpl5 Pla1a Osbpl8 Pla2g4f Osbpl10 Pla2g2d Pla2g2f Pla2g2a Pla2g4a Pla2g4e Pla2g1b Pla2g4d Pla2r1 Pla2g4b Pla2g12a Lpcat3 Lpcat4 Pla2g10 Plaat3 Pla2g5 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231506 Negative regulation of NOTCH4 signaling Akt1 CELL CYCLE CHECKPOINTS%REACTOME%R-RNO-69620.1 Cell Cycle Checkpoints Cenpl Rad50 Cenpk Cdc25c Dynll1 Cenpi Cdc25a Dynll2 Cenph Cenpf Ndc80 Csnk1a1 Babam1 Babam2 Topbp1 Rbbp8 Psma4 Psma3 Brca1 Psma6 Psma5 Uimc1 Ywhae Psma2 Psma1 Rad1 Ywhag Psmd12 Psmd11 Hist1h2bq Psmd14 Ppp2r5b Psmd13 Ppp2r5a Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Gsk3b Psma7 Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Ube2d1 H2bc6 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Plk3 Rps27 Ccnb2 Ccnb1 Plk1 Cdk1 Ccnb2-ps2 Csnk1e Rps27a Nudc Ube2n Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Ube2s Ccne1 Ccne2 Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Btrc Anapc7 Ube2e1 Cdc16 Ppp2r5d Pkmyt1 Cop1 Ubb Mdm4 Zfp385a Ubc Gtse1 Exo1 Wee1 Rfc5 Rfc3 Cenpe Mapk14 Rfc4 Nup98 Rfc2 Nup37 Ppp2r1b Ppp2r1a Nup107 Cul1 Nup160 Mapk11 Nup85 Mcm7 Dync1li2 Mcm8 Nup43 Dync1li1 Xpo1 Dbf4 Orc5 Orc4 Ranbp2 Orc6 Orc1 Orc3 Orc2 Nup133 Rpa1 Rpa2 Cdc7 Tp53 Cdc6 Rpa3 Cdk2 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Itgb3bp Cdkn1b Ywhaq Ywhah Ywhab Pafah1b1 Sfn Zw10 Clip1 Kif18a Dync1h1 Phf20 Pias4 Mre11 Kat5 Nbn Hus1 Dync1i2 Atrip Dna2 Dync1i1 Blm Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Sec13 Clspn Rad17 Clasp1 Clasp2 Spc24 Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Atm Atr Cdca8 Incenp Knl1 Ccna1 Mad2l1 Ccna2 Tp53bp1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Rmi2 Ska1 Rmi1 Ahctf1 Mapre1 Zwint Brip1 B9d2 Brcc3 Ska2l1 Bub1 Ppp1cc Herc2 Taok1 Rnf168 Nde1 Rcc2 Kntc1 ABRAXAS1 Mad1l1 Rbx1 Cenpu Kif2a Cenpt Kif2b Ywhaz Rnf8 Cenpq Kif2c Rhno1 Cenpp Cenpo Wrn Cenpn Nsd2 Cenpm Mis12 Psmb6l1 Zwilch MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-RNO-9939291.1 Matriglycan biosynthesis on DAG1 Slc35a1 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 B4gat1 Large1 Large2 Pomgnt1 Fktn N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%10230232 N-glycan trimming in the ER and Calnexin Calreticulin cycle Engase Ngly1 Rad23b Rps27a Calr Ubxn1 Ubb Psmc1 Ubc Uba52 Pdia3 Canx Vcp Amfr UCH PROTEINASES%REACTOME DATABASE ID RELEASE 97%10231030 UCH proteinases Nfrkb Foxk2 Foxk1 Uchl3 Uchl5 Kdm1b Ino80e Ino80d H2ac18 Tfpt Ino80c Psma4 Ino80b Psma3 Actr5 Psma6 Actr8 Ruvbl1 Psma5 Senp8 Psma2 Asxl1 Psma1 Mbd5 Mbd6 Uchl1 Asxl2 Ino80 Psmd12 Psmd11 Psmd14 Psmd13 Actg1 Actl6a Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Yy1 Hcfc1 Psmd7 Psmd6 Psmd8 Psmd2 Bard1 Rps27a Psmd1 Adrm1 Mcrs1 Hist1h2ai Ogt Uba52 Bap1 Nedd8 Ubb H2ac4 Ubc H2ac25 Psmb6l1 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 97%10230336 ISG15 antiviral mechanism Plcg1 Nedd4 Ube2e1 Mapk3 Irf3 Ube2n Stat1 Usp18 Ube2l6 Ppm1b Mx2 Uba7 Rig1 Eif2ak2 Arih1 Trim25 Becn1 Isg15 Flnb WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 97%10230846 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ror1 Ror2 Fzd2 Fzd5 Wnt5a Cltb Ap2b1 Ap2a2 Ap2s1 Ap2a1 Clta Cltc Ap2m1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 97%10230200 Heparan sulfate heparin (HS-GAG) metabolism Sdc4 Sdc3 Gpc1 Gpc3 Gpc2 Gpc4 Gpc6 Agrn Idua Sdc1 Sdc2 Ids Hs3st4 Hs3st1 Extl2 Hs3st2 Naglu Hs3st5 Hs3st6 Hs3st3b1 Hpse2 Hpse Hs2st1 Ndst1 Ndst2 Ndst3 Slc35d2 Ndst4 Hs3st3a1 Hs6st3 Hs6st2 Ctsl Hs6st1 Gpc5 Sgsh Ext2 Ext1 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229358 Lanosterol biosynthesis Plpp6 Fdps Idi1 Mvk Fdft1 Sqle Hmgcs1 Ggps1 Acat2 Lss Pmvk Hmgcr Mvd METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin Aldh2 Maoa PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%10230850 PINK1-PRKN Mediated Mitophagy Mterf3 Tbk1 Prkn Rps27a Ube2l3 Ube2n Ube2d2 Map1lc3b Sqstm1 Optn Uba52 Mfn1 Mfn2 Ubb Map1lc3a Ubc Pink1 Tomm7 Atg5 Tomm40 Atg12 Tomm22 Tomm20 Vdac2 Vdac3 Vdac1 Tomm70 Ube2d3 Atg9a KERATAN SULFATE DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230514 Keratan sulfate degradation Glb1l3 Fmod Glb1l2 Galns Gns Hexa Lum Hexb Omd Acan Glb1 Ogn Glb1l Kera Prelp SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%10230590 Signaling by Hippo Mob1a Lats1 Tjp2 Mob1b Lats2 Wwc1 Wwtr1 Amotl2 Amotl1 Stk4 Yap1 Amot Stk3 Sav1 Nphp4 Ywhab Ywhae Tjp1 Casp3 Dvl2 SIGNALING BY RHO GTPASES%REACTOME%R-RNO-194315.1 Signaling by Rho GTPases Cenpl Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ndc80 H2ac18 Cul3 Sh3rf1 Ywhae Stam2 Steap3 Ywhag Hist1h2bq Ctnnb1 Pik3c3 Ppp2r5b Ppp2r5a Dvl1 Dvl3 Als2 Fnbp1 Pik3r4 Ppp2r5e Atp6ap1 H2aj H3-3b Hist3h2ba H2bc18 H2az2 H2bc6 H2bc4 Usp9x Hist1h4m H2bc1 Hist1h2ai Sptbn1 Ptk2 Sptan1 Grb2 Sos1 Arl13b Vim Rps27 Kdm1a Ndufs3 Ndufa5 Rbbp6 Stom Hsp90aa1 Ncf1 Ncf2 Ncf4 Hsp90ab1 Brk1 Baiap2 Nck1 Nckap1l Nup98 Nckap1 Nup37 Elmo2 Nup107 Prkcz Wasf3 Nup160 Wasf2 Wasf1 Jup Nup85 Abi2 Cyba Abi1 Nup43 Cybb Cyfip2 Aaas Cyfip1 Xpo1 Pdpk1 Ranbp2 Nup133 Lamtor1 Rhoa Ngef Zap70 Flot2 Flot1 Slitrk5 Slitrk3 Lck Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ddx39b Fermt2 Actn1 Ect2 Prex1 Flna Trio Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Ywhaq Ywhah Ywhab Sfn Hnrnpc Pde5a Srrm1 Ppp1cb Clip1 Cdh1 Ctnna1 Iqgap2 Iqgap3 Men1 Ncoa2 Vav1 Pik3r1 Pik3r2 Pik3r3 Cpsf7 Rapgef1 Pik3ca Sos2 Tra2b Ywhaz Ptk2b Cdc25c Rhoc Rhob Lmnb1 Picalm Ocrl Cltc Wipf3 Wipf1 Btk Nckipsd Limk1 Tfrc Cpd Ckb Kdm4c Ppp1r12b Ppp1r14a Ar Ppp1r12a Cftr Lman1 Gja1 Mtr Dbt Itsn1 Itsn2 Hmox2 Myo6 Emd Plk1 Cdc37 Vrk2 Prkcb Rasal2 Diaph1 Snap23 Pard6a Daam1 Pfn1 Mapk1 Vangl2 Golga3 Nudc Mapk3 Rnd2 Muc13 Wdr6 Txnl1 Rac2 Kif14 Scrib Rac3 Rbmx Ptpn13 Nisch Vamp3 Arhgap35 Ppp2cb Dst Depdc1b Ppp2ca Cav1 Fam83b Frs2 Ubxn11 Frs3 Kctd13 Epha2 Kidins220 Ktn1 Arhgap5 Grb7 Plxnd1 Prag1 Arhgap1 Dlg5 Ankrd26 Dsg1 Bltp3b Tnfaip1 Ckap4 Gps1 Ppp2r5d Cct2 Stx5 Ykt6 Trip10 Cenpe Mapk14 Arfgap3 Ppp2r1b Ppp2r1a Mapk11 Klc1 Dync1li2 Rhog Dync1li1 Arhgdib Garre1 Shmt2 Klc4 Klc3 Rac1 Arhgdig Lbr Klc2 Diaph3 Dvl2 Vav3 Cdc42ep1 Pgrmc2 Dock5 Cops4 Dock3 Dock4 Dsg2 Arhgap21 Letm1 Mcam Vav2 Arpc3 Ophn1 Cops2 Stbd1 Pld1 Arhgdia Arpc2 Dock2 Vapb Arhgap32 Pak4 Esyt1 Plekhg3 Mpp7 Arpc5 Ankle2 Itgb3bp Map3k11 Arpc4 Hspe1 Pak1 Spata13 Srgap1 Srgap2 Srgap3 Arhgap45 Gmip AABR07032856.1 Arhgap10 Arhgap17 Bcr Pak2 Dock6 Arhgap4 Fam13b Dock7 Dock8 Arap1 Arap3 Arap2 Arhgap22 Arhgap9 Arhgap20 Prkcd Syde1 Arhgap26 Arhgap24 Cep97 Arhgap29 Osbpl11 Prkca Arhgap27 Pard6b Def6 Uaca Myo9b Arhgap6 Arhgap33 Mrtfa Arhgap31 Arhgap8 Arhgap30 Stmn2 Dnmbp Fam91a1 Prex2 Calm3 Mylk Tagap Mtmr1 Dock10 Samm50 Dock11 Fam169a Plekhg1 Baiap2l2 Farp1 Vma22 Ralbp1 Gopc Stard8 Ralgapa1 Itgb1 Dlc1 Wwp2 Stard13 Fam135a Arhgap40 Wdr11 Arhgap44 Tuba1b Arhgap42 Msi2 Cdc42bpa Stip1 Cdc42ep4 Slk Syde2 Phip Pld2 Tpm4 Abl2 Akap12 Slc1a5 Jag1 Stk38 Scfd1 Nox3 Tex2 Nox1 S100a9 S100a8 Swap70 Amigo2 Stk10 Noxa1 Arhgap19 Arhgap15 Arhgap18 Arhgap12 Evl Pafah1b1 Cit Rhobtb2 Rhobtb1 Zw10 Fam13a Baiap2l1 Srf Arhgap25 Arhgap28 Arhgap23 Pcdh7 Csk Fgd5 Prc1 Rnf20 Pak6 Cct6a Pak5 Cdc42bpb Fmnl1 Slc4a7 Git2 Sowahc Aldh3a2 Noxo1 Taok3 Senp1 Chn2 Pfn2 Plekhg6 Tiam1 Twf1 Epsti1 Farp2 Cpne8 Sh3bp1 Pkn2 Nck2 AABR07021573.2 Pkn1 Nipsnap2 Git1 Faf2 Rhoh Abcd3 Rhof Acbd5 Actr2 Anln Rhoj Actb Rhou Actr3 Rhov Arpc1b Arpc1a Rhoq C1qbp Scai Arhgef28 Arhgap11a Emc3 Cct7 Myo9a Ccdc88a Stam Tmem59 Kalrn Mtx1 Cavin1 Tmod3 Arhgef7 Cdc42ep2 Cdc42ep3 Plxna1 Rras2 Rtkn Nsfl1c Rhpn1 Rhpn2 Ccdc187 Basp1 Pak3 Ddrgk1 Lin7b Kif18a Actg1 Maco1 Cdc42 Ddx4 Peak1 Rnd3 Rnd1 Spen Rock2 Armcx3 Rock1 Add3 Ccp110 Rab7a Tor1aip1 Dync1h1 Dlg4 Sema4f Fmnl2 Actc1 Fmnl3 Tmem87a Zfp512b Dync1i2 Dync1i1 Abl1 Sec13 Racgap1 Clasp1 Clasp2 Spc24 Birc5 Dsp Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Bcap31 Ndel1 Sgo2 Sgo1 Tjp2 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Mapre1 Kif5a Zwint Kif5b B9d2 Ska2l1 H2ab2 Bub1 Ppp1cc Taok1 Nde1 Rcc2 H2ac4 Hgs Kntc1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Cenpq Kif2c Cenpp Vcp Cenpo Cenpn Cenpm Mis12 Zwilch PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-RNO-69200.1 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Rb1 Ccne1 Cdk2 Ccne2 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%10230172 Deposition of new CENPA-containing nucleosomes at the centromere Cenpl Cenpk H2bc6 Cenpi Cenph Npm1 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 H2ac18 Hist1h2ai Ruvbl1 Hist1h2bq Knl1 Cenpc Cenpa H2aj H2ab2 Rsf1 Smarca5 Oip5 Hist3h2ba Mis18a Itgb3bp Cenpw H2ac4 Mis18bp1 Hjurp Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm H2az2 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells Slc38a1 Slc1a3 Slc1a2 Glul BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-RNO-77352.1 Beta oxidation of butanoyl-CoA to acetyl-CoA Acads Echs1 Hadh HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%10230754 HDMs demethylate histones Kdm5a Kdm6b Kdm6a Kdm4b Kdm7a Kdm4a Arid5b Uty Hist1h4m Kdm4c Jmjd6 Kdm1b Kdm1a Phf2 Riox2 Kdm2b Kdm4d H2bc18 Kdm3b Kdm5c Kdm3a Kdm5b Phf8 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%10228474 mRNA Splicing Snrpg Snrpb Snrpd1 Ncbp2 Ncbp1 Snrpd3 Snrpepl2 Ppil2 Hspa8 Snrnp200 Phf5a Rnps1 Fam50a Smndc1 Pnn Znf830 Hnrnpr-ps2 Rnf113a2 U2surp Crnkl1 Cdc40 Aqr Pcbp2 Prcc Pcbp1 Ddx39b Magoh Upf3b Tfip11 Hnrnpr Dhx8 Wdr70 Hnrnpu Snrpa1 Rbm10 Steep1 Dhx38 Dhx35 C3h9orf78 Ptbp1 Eif4a3 Zrsr2 Rnpc3 Hnrnpc Hnrnpd Hnrnpf Ppwd1 Hnrnpk Hnrnpl Gcfc2 Dhx16 Ccdc12 Dhx15 Srsf19 Srsf11 Srsf12 Srrm1 Rbm8a Sde2 Slu7 Rnf113a1 Srrm2 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Nkap Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Hnrnph2 Hnrnph1 Leng1 Prpf6 Mfap1al1 Zmat5 Cactin Ppig Ppie Hnrnpa2b1 Srrt Rbmx2 Cwc22 Nsrp1 Cwc27 Cwc25 Zcrb1 Prpf8 Wbp11 Prpf19 Prpf18 Snrnp40 Eftud2 Snrnp48 Snip1 Fam32a Snrpn Alyref Cwc15 Cherp Yju2 Fus Gpatch1 Casc3 Magohb Pqbp1 Isy1 Rbmx Cdc5l Snrnp25 Ybx1 Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Acin1 Srsf2 Rbm22 Snrnp35 Hnrnpa3 Rbm17 Syf2 Ddx46 Bud31 Ddx41 Ddx42 Puf60 Cwf19l2 Polr2c Ctnnbl1 Polr2a Ppil4 Polr2b Ppil3 Polr2g Polr2h Hnrnpa1 Polr2e Ppil1 Polr2f Sap18 Polr2i Polr2j Tra2b Bud13 Bcas2 Snrpf Pdcd7 Ddx23 Gtf2f2 Gpkow Gtf2f1 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%10230482 Degradation of DVL Psmd8 Psmd2 Rps27a Psmd1 Cul3 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Hecw1 Klhl12 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Dvl2 Dvl1 Dvl3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Dact1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Psmd7 Psmd6 Psmb6l1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%10230768 STAT6-mediated induction of chemokines Tbk1 Sting1 Stat6 ADAPTIVE IMMUNE SYSTEM%REACTOME%R-RNO-1280218.1 Adaptive Immune System Cd28 Prkag1 Lrr1 Cd22 Dynll1 Prkag2 Nedd4 Cd40 Dynll2 Ost4 Psme2 Cops5 Cd34 Psme1 Sipa1 Kif3a Ccnd1 Rnf220 Cd200r1l Tmem258b Tusc3 Cbll1 Madcam1 Kif3b Psmb10 Cdk4 Pvr Kmt2a Fbxl21 Cd40lg Kmt2c Rnf213 LOC120093164 Kif3c Wsb1 H2ac18 Cd86 Cul3 Rnf217 Cd80 Ube2d2 Hecw2 Ezh2 Rap1gap2 Psma4 Ccnf Cd96 Psma3 Cblb Crtam Psma6 RT1-M6-2 Sell Sh3rf1 Erlec1 Vcam1 Trim11 Psma5 Cd8b Vhl Ube2l6 Psma2 Cd8a Mex3c Psma1 Cul2 Cd300le Eloc Cdc34 B3gnt3 Cd300ld Csnk2a2 Elob B2m Cd300lg Dcaf1 Dad1 Cd300lf Csnk2a1 Rnf126 Dapp1 Rnf123 Ywhag Nfatc3 Psmd12 Trib3 Cd207 Nfatc2 Psmd11 Ubac1 Klrb1a Lnpep Suz12 Klrk1 Dnm1 Atg7 Hist1h2bq Clec4g Psmd14 Rnf114 Blnk Psmd13 Rnf115 Ppp2r5b Trat1 Hace1 Wdr5 Ppp2r5a Clec2e Ash2l RT1-M10-ps5 Ddost Siah1 Dnm3 Psmb5 Siah2 Psmb4 Keap1 Dzip3 Csnk2b Mrc2 Psmb7 Them4 Mrc1 Psmb6 Psmb1 Mkrn1 Ppp2r5e Ube2g2 Eed Kif20a Psmb3 Calr Sec24d Ube2g1 Psmb2 Rnf138 Gsk3b Kifap3 Cd274 RT1-N3 Sec24c Kbtbd7 H2aj Sec24b Rnf130 Os9 Kbtbd8 Psma7 Sec24a Fbxw4 H3-3b Psmc5 Fbxw5 Hist3h2ba Fbxw7 Psmc2 Gan Psmc1 Fbxw8 Psmc4 Fbxw9 Psmc3 Cd36 Anapc13 Pdcd1 Det1 Rnf5 Sel1l Fbxw2 Klhl5 H2bc18 Rbck1 Nek2l1 Arih2 Magt1 Rlim Psmd7 Psmb9 Psmd6 Ube2d3 H2az2 Klhl3 Psmb8 Psmd8 Psmd2 Klhl2 Ube2d1 Ube4a Rnf111 H2bc6 Spsb2 Rbbp5 Smurf2 Trim9 Rbbp4 Smurf1 Spsb1 H2bc4 Trip12 Hist1h4m RT1-M1-5 H2bc1 Spsb4 Rbbp7 Rt1-ec3 Mib2 Psmd1 Lrsam1 Pdcd1lg2 Huwe1 Ube2j2 Adrm1 Ube2j1 Prkab2 Hist1h2ai Kctd7 Ube2u Prkab1 Kctd6 Ube2w Ube2m Ube2k Rnf182 Ube2o Pdia3 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Sptbn2 Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Nras Rnf19a Ubr2 Grb2 Glmn Fyn Ubr4 Kras RT1-M2 Sos1 Fbxo27 Hras Uba5 Uba6 Uba7 Trim69 Fbxw17 Cd81 Trim71 Klhl25 Ube2e3 Ube2e2 Klhl21 Rnf19b Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Hspa5 Cd19 Uba1 Uba3 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Asb13 Trpc1 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fcgr1a Fbxo9 Trim21 Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Erap1 Asb9 Asb7 Cd74 Asb6 Lag3 Asb5 Rnf25 Asb4 AABR07044308.1 Asb1 Lnx1 Ppl Wwp1 Prr5 Ncf1 Ncf2 Ncf4 Rictor Itgav Nck1 Mapkap1 Cyba Cybb Pdpk1 Rap1a Lyn Yes1 Src Zap70 Fkbp1a RT1-Db2 Cd247 Cd3g RT1-Db1 Mtor Cd3e Cd3d Trav19 AC109737.1 Mlst8 Cd4 RT1-Ha Ptprc Lck Icoslg Ptpn22 RT1-Ba Pik3r5 RT1-Bb Pik3r6 ENSRNOG00000065955 Pik3cg Icos Trbv16 RT1-Da Raf1 Ltn1 Rchy1 Ywhab Prkg1 Itpr1 C3 Skp2 Syk Vav1 Pik3r1 Pik3r2 Pik3r3 Canx Socs1 Socs3 Inpp5d Pik3cb Pik3cd Pik3ca Ywhaz Ptpn6 Ptpn11 Xdh Arf1 Clta Ap1b1 Cltc Vamp8 Ap1s3 Ap1s2 Ap1g1 Dnm2 Btk Fcgr2 Sh3gl2 Ap1m2 Ap1m1 Itpr3 Itpr2 Actr1a Dctn1 Dctn2 Akt3 Akt2 Dctn4 Akt1 Rap1b Rapgef4 Rapgef3 Rasgrp1 Rasgrp2 Prkcb Snap23 Itch Ikbkb Traf6 Ikbkg Map3k8 Ppp3ca Rps27a Map3k7 Ppp3cb Ube2n Nfkb1 Nfatc1 Ppp3r1 Vamp3 Skp1 Ppp2cb Ppp2ca Uba52 Sec31a Fbxw11 Ube2s Btn1a1 Btnl9 Btn2a2 Ube2c Rela Cd209a Cdc27 Cdc26 Btnl2 Cdc23 Anapc10 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Btrc Anapc7 Ube2e1 Cdc16 Ctsb Ctsd Actr10 Ctnnbl1 Ppp2r5d Ctse Ctsf RT1-DMb Actr1b Ctsh Ctsk Ctsl Ubb Ctso Ripk2 Ap2s1 Ctss Ubc Exo1 Ifi30 Aicda Rfc5 Nfkbib Pold2 Rfc3 Cenpe Mad2l2 Rfc4 Mylip Pcna Rfc1 Rfc2 Pold3 Rev1 Nfkbia Msh6 Msh2 Rilp Ctsa Prkcq Ppp2r1b Mcm3ap Ppp2r1a RT1-DOa RT1-DOb Cul1 Osbpl1a Pms2 Mlh1 Tab2 Rev3l Apex2 Poli Polh ENSRNOG00000069193 Chuk AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Klc1 Ighl12 ENSRNOG00000062682 Dync1li2 ENSRNOG00000070812 ENSRNOG00000070415 Dync1li1 ENSRNOG00000070810 ENSRNOG00000066926 Klc4 ENSRNOG00000066406 Klc3 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Klc2 ENSRNOG00000070192 Plcg1 Iglc1 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Lcp2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Pak1 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 Ap2m1 ENSRNOG00000063713 ENSRNOG00000062820 Pak2 Grap2 Pag1 ENSRNOG00000064490 ENSRNOG00000066072 Sh3kbp1 AABR07065781.1 Sar1b ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Prkaca Lat Prkacb ENSRNOG00000067643 Calm3 Itgb1 Lgmn Csk Pak3 Kif18a Cdc42 Ctsc Rab7a Dync1h1 Kif11 Kif15 Dync1i2 Dync1i1 Kif22 Ube2v2 Kif23 Prkn Cxadr Siglec1 Ube2l3 Siglec5 Sec13 Siglec8 Ap2b1 LOC100910497 Bcl10 Racgap1 Pik3ap1 Nfkbie Fyb1 Slamf6 Slamf7 Rel Itk Hcst Kir3dl1 Pilrb2l4 Ctla4 Ifitm1 Ifitm2 Cdc20 Ifitm6 Pilrb1l3 Pilrb1l2 Map3k14 Stub1 Rap1gap Jaml Malt1 Kif4b Pilrb-ps7 Cd160 Kif4a Itga4 Kif26a Btla Itgal Itgb7 Stim1 Pianp Itgb2 Siglec10 Pten Kif5a Trem2 Kif5b Trem1 Cd226 H2ab2 Nectin2 Rnf185 Herc2 Cd101 Prkaa1 Ifitm3-ps2 Derl3 Sec23a LOC134481331 Derl2 Ap2a2 Lair1 H2ac4 Ap2a1 Icam1 Stt3b Rbx1 Icam5 Erlin2 Icam4 Kif2a Spop Icam2 Kif2b Erlin1 Cd79a Kif2c Cd79b Vcp Rpn2 Treml2 Rpn1 Treml4 Cd200 Ostc Cd1d Prkag3 Psmb6l1 ifitm3 FOXO-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10229502 FOXO-mediated transcription Atxn3 Foxg1 Foxo6 Smad2 Foxo4 Smad3 Foxo1 Sirt3 Ywhaq Akt3 Ep300 Ywhab Akt2 Sfn Akt1 Crebbp Kat2b Sirt1 Ywhag Ywhaz Smad4 Foxo3 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231368 Interleukin-9 signaling Stat5a Il9 Stat5b Jak3 Il9r Stat3 Stat1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors Cubn Ldlrap1 Shmt1 Nt5e Mccc1 Mccc2 Shmt2 Mtrr Nampt Abcc1 Pdxk Naxe Slc52a2 Slc52a3 Lrpl1 Btd Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Cblif Tcn2 Fpgs Mmut Mthfs Mthfr Slc25a32 Slc46a1 Slc23a1 Mthfd1l Slc23a2 Naprt Mmadhc Slc2a1 Gsto1 Pcca Slc2a3 Gsto2 Rfk Dcakd Pccb Acp5 Aox1 Ppcdc Coasy Nadk2 Nudt12 Mthfd2l Nmrk1 Cyb5a Mocs3 Slc25a16 Ppcs Hlcs Aldh1l1 Aldh1l2 Cd38 Lrp2 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Flad1 Mmab Rnls Enpp1 Mocs1 Mmachc Slc22a13 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Mthfd2 Gphn Pank3 Pank2 Pank4 Mocos Pank1 Mtr Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Nfs1 Folr2 Bst1 Vnn1 Amn Pc REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%10230038 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Tesk1 Actn1 Arhgef6 Parvb Pxn Parva ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides Defal1 Pglyrp1 Tlr1 Pglyrp2 Reg3a Pglyrp3 Reg3b Pglyrp4 Defa31 Stath Reg3g Defa Camp Ltf Tlr2 Chga Lyz1 Bpifa1 Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Ctsg Defb24 Defb1 Defb25 Eppin Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Ccr6 Cd4 Try10 Prss2l1 Pla2g2a Bpi Elane Slc11a1 Try5 LOC102554637 S100a9 S100a8 Prss2 Prss3 Prtn3 Atp7a Prss1 Defb41 Defb42 Np4 Defb43 Defb44 Clu Defa24 Svs3b Ear1 Bpifb2 Bpifb1 Bpifb6 Bpifb4 MET PROMOTES CELL MOTILITY%REACTOME%R-RNO-8875878.1 MET promotes cell motility Dock7 Rap1a Megf11 Rapgef1 Lama4 Tns4 Tns3 Hgf Ptk2 Src Itga3 Met Grb2 Itga2 Rap1b Gab1 Crk Rac1 Itgb1 Crkl NEUREXINS AND NEUROLIGINS%REACTOME DATABASE ID RELEASE 97%10231120 Neurexins and neuroligins Lrrtm2 Lrrtm3 Lrrtm4 Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Nlgn3 Cask Epb41l1 Grm1 Shank1 Grm5 Dlg2 Shank3 Dlg3 Homer1 Dlg4 Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Epb41l2 Epb41l3 Epb41l5 Lrrtm1 Sh3glb2 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-RNO-112303.1 Electric Transmission Across Gap Junctions Gja10 Gjc1 Gjd2 Panx2 Panx1 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%10231236 TBC RABGAPs Tbc1d10c Rab35 Tbc1d10b Tbc1d14 Tbc1d10a Ulk1 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Map1lc3b Rab11b Rab8b Optn Rab11a Rab8a Rabgap1 Rab4a Sytl1 Tbc1d25 Tbc1d24 Arf6 Gabarap Rab7a Rab33b Gabarapl2 Rab7b Rab33a Tbc1d2 Tsc2 Tbc1d7 Tsc1 Rab6b Rab6a ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 97%10230952 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ncoa2 Pkn1 H2bc6 H2bc4 Hist1h4m Kdm4c H2bc1 Ar H2ac18 H2aj Hist1h2ai H2ab2 Kdm1a H3-3b Hist3h2ba H2ac4 H2bc18 Hist1h2bq H2az2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%10230490 Activation of Matrix Metalloproteinases Mmp13 Mmp14 Mmp2 Mmp9 Mmp15 Mmp16 Mmp17 Mmp8 Try10 Prss2l1 Ctrb1 Mmp10 Plg Klkb1 Elane Ctsg Furin Cma1 Try5 LOC102554637 Mmp7 Mmp3 Timp1 Timp2 Prss2 Prss3 Ctsk Mmp1b Tpsb2 Prss1 Spock3 Mmp24 Mmp25 Col18a1 ENSRNOG00000069479 Mmp11 PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism P4hb Cga Cpb2 Ctsg Fshb Tshb Bche Ero1b Ctsz Ces1d Cpa3 Mme Exoc3 Inha Exoc4 Exoc5 Ffar1 Exoc6 Sec11c Exoc1 Exoc2 Sec11a Ren1 Ace2 Enpep Exoc7 Exoc8 Mboat4 Atp6ap2 Ffar4 Gzmf Inhba Dpp4 Gh1 Ghrl Pla2g7 Spcs3 Ace Spcs1 Spcs2 Igf1 Pcsk1 Lep Gpr119 Inhbb Cpb1 Inhbc Inhbe Grp Pomc Slc30a5 Cma1 Slc30a8 Ins1 Ctsd Ins2 Gip Gcg Lhb Agt CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation Rps6ka1 Rps6ka2 Rps6ka3 Mapkapk2 Atf1 Rps6ka5 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME%R-RNO-400206.1 Regulation of lipid metabolism by PPARalpha Ncoa2 Sin3a Tbl1x Sin3b Ncor2 Carm1 Tgs1 Med1 Crebbp Smarcd3 Ppara Hdac3 Rxra Tbl1xr1 Fabp1 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229976 Tight junction interactions Pard6a Pard3 Pard6g F11r Prkci Pard6b ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-264642.1 Acetylcholine Neurotransmitter Release Cycle Syt1 Vamp2 Stxbp1 Unc13b Cplx1 Rims1 Stx1a Rab3a Slc18a3 Slc5a7 Ppfia3 Snap25 Tspoap1 Ppfia2 Ppfia4 Ppfia1 Chat DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%10228638 Developmental Biology Cdk4 Csnk2a2 Csnk2a1 Gab1 Dnm1 Grb10 Ctnnb1 Dnm3 Csnk2b Foxo1 Gsk3b Smad4 Smad2 Smad3 Met Cdon Spta1 St8sia4 Ptpra Col4a1 Col4a2 Ncam1 Sptbn1 Numb Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Sptbn4 Nras Grb2 Fyn Kras St8sia2 Sos1 Hras Hdac1 Sirt1 Tnfsf11 Cdsn Klk5 Kazn Lars1 Klk8 Crmp1 Ppl Bnip2 Tgm1 Krtap24-1 Sprr3 Sox10 Stfa2l3 Rdx Casp14 Krtap13-1 Evpl Myog Cela2a Ret Spink6 Kars1 Spink5 Krtap10-9 Perp Cdk5r1 Klk12 Sytl2 Pkp2 Mef2d Pkp3 Lipk LOC120093742 Krtap11-1 Hsp90aa1 Dsg4 Mef2a Dsc1 Mef2b Dsc2 Mef2c Rptn Lipm Dscaml1 Adgrg6 Klk14 Mitf Klk13 Cdh2 Dsc3 Lipn Ctnna2 Shc3 Nrp1 Qars1 Tyrobp Dab1 Tfap2c Krtap31-2 Krtap31-1 Hsp90ab1 Tfap2b Krt33b Krt33a Rxra Eprs1 Itgav Pdlim7 Boc Ntn4 Nck1 Rars1 Nfasc Iars1 Tbx3 Itgb3 Spag9 Unc5a Krtap2-4l1 Krtap3-1 Krt4 Krt2 Krtap3-2 Krt1 Krt8 Krt7 Krt5 Mapk12 Krt9 Ezr Hint1 LOC680428 Stx1b Jup Aimp2 Crebbp Sema7a Krt27 Krt28 Krt25 Krt26 Krtap29-1 Hdac3 Mark3 Artn Xpo1 Adam11 Lypla2 Krt24 Gfra1 Rara Gfra2 Map2k1 Foxo3 Krt20 Gfra4 LOC134481131 LOC102553726 Krtap5-8 Krt39 Krt36 Adam23 Rras Shank3 Kit Krt34 Ncor2 Krt35 Krt32 L1cam Lyn Krt31 Ep300 Yes1 AABR07001416.1 Src Krtap6-5 Rhoa Dpysl2 Ngef Dpysl3 Dpysl4 Krt18 Dpysl5 Kitlg Krt19 Krt17 Krt14 Krt15 Map2k2 Krt12 Krt13 Ptprc Krt10 Cd72 Plxnb1 Plxnb3 Krtap16-5 Plxna4 Krtap16-1 Arhgef11 Plxna3 Krt6a Arhgef12 Plxna2 Dok1 Krt71 Dok2 Reln Dscam Dok4 Dok5 Dok6 Krt78 Krt76 Krt77 Krt75 Krt72 Krt73 Pspn Gdnf Krt40 Msn Plxnc1 Fes Myf6 Tcf4 Nrtn Trio Myf5 Sema6d Krtap1-3 Krtap1-1 Gap43 Krtap1-5 Cdh15 Mars1 Sema5a Myrip Dars1 Myod1 LOC134478810 Krt82 Adam22 Sema4d Krt80 Sema4a Krt85 Krt86 Krt83 Krt84 Lgi2 Lgi3 Lgi4 Lgi1 Sema3a LOC102551497 Sema3e Stx1a Ctnna1 Gab2 Pik3r1 Pik3r2 Pik3r3 Pparg Irs2 Csf1 Shc1 Pik3cb Pik3cd Pik3ca Ptpn11 Tfap2a Rhoc Rhob Clta Cltc Dnm2 Myo5a Sh3gl2 Limk1 Ranbp9 Itga9 Cebpa Akt3 Akt2 Akt1 Tcf7 Itga2b Tcf7l1 Itsn1 Tln1 Erbb2 Mapk7 Mapk1 Tcf7l2 Rab27a Mapk3 Lef1 Arhgap35 Frs2 Epha2 Grb7 Rps6ka5 Plxnd1 Tcf3 Rps6ka1 Sin3a Dsg1 Tcf12 Ap2s1 Pip5k1c Mapk14 Vldlr Prkcq Egfr Mapk11 Rac1 Vav3 Plcg1 Dsg2 Vav2 Arpc3 Cdk2 Arpc2 Arpc5 Arpc4 Pak1 Ap2m1 Pak2 Sh3kbp1 Cacng8 Prkaca Cacng4 Prkacb Cacng2 Cacng3 Prkca Myo9b Itgb1 Cdk5 Fgfr1 Tiam1 Farp2 Efna1 Efna2 Nck2 Git1 Sdcbp Ank1 Mmp2 Mmp9 Epha1 Actr2 Epha3 Actb Epha4 Actr3 Arpc1b Arpc1a Epha5 Psenen Arhgef28 Epha6 Epha7 Psen1 Epha10 Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Rasa1 Plxna1 Sdc2 Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Grin1 Pak3 Actg1 Cdc42 Efnb1 Efnb2 Efnb3 Rnd1 Rlc-a Rock2 Rock1 Efna4 Efna5 Grin2b Dlg4 Ube2i Pkp1 Abl1 Ap2b1 Dsp Dcc Dsg3 Rap1gap Kif4b Kif4a Trem2 Ap2a2 Sumo1 Ap2a1 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-RNO-6811442.1 Intra-Golgi and retrograde Golgi-to-ER traffic Arfgap3 Copa Dynll1 Arfgap2 Dynll2 Arfgap1 Kif3a Kif3b Nbas Rab36 Kif3c Rab3gap2 Use1 Rab3gap1 Copb2 Rab1b Arf1 Copb1 Rabepk Cope Arl1 Klc1 Kif21a Dync1li2 Kif21b Dync1li1 Napa Klc4 Klc3 Klc2 Bet1l Gosr1 Gosr2 Kif20a Kif20b Kifap3 M6pr Ttgn1 Pla2g4a Igf2r Galnt1 Galnt2 Rhobtb3 Rint1 Vps51 Vps52 Vps54 Rab1A Vps45 Rab18 Bicd2 Bicd1 Agpat3 Pafah1b3 Gcc2 Pafah1b2 Pafah1b1 Zw10 Cog1 Cog2 Cog3 Cog4 Cog5 Cog6 Cog7 Cyth2 Cog8 Cyth3 Cyth4 Actr1a Cyth1 Dctn1 Dctn2 Arfrp1 Dctn4 Akp3 Vti1a Bnip1 Alpp Usp6nl Kif18a Kif18b Alpi Kdelr2 Kif19 Kdelr3 Alpg Rab33b Dync1h1 Scoc Tmed9 Kif11 Kif12 Kif15 Kif1c Snap29 Kif1a Kif1b Kdelr1 Dync1i2 Kif6 Rab6b Rab6a Dync1i1 Arf4 Kif9 Arf3 Stx16 Kifc1 Stx18 Kifc2 Kif22 Kif23 Kif28 Tmed10 Kif27 Kif16b Rab9a Rab39a Rab9b Pla2g6 Racgap1 Gbf1 Tmed2 Tmed3 Copg1 Vamp3 Copg2 Vamp4 Tmed7 Rgp1 Copz2 Sys1 Kif4b Kif26b Copz1 Kif4a Arf5 Kif26a Golga4 Tmf1 Golga1 Nsf Napb Actr10 Kif5a Kif5b Stx6 Stx5 Kif13b Napg Ykt6 Ric1 Kif2a Trip11 Kif2b Arfip2 Kif2c Arcn1 Cenpe Rab43 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-RNO-1660514.1 Synthesis of PIPs at the Golgi membrane Pi4k2a Pik3r4 Arf1 Ocrl Pi4k2b Inpp5e Pi4kb Pikfyve Pi4ka Pik3c2g Tpte2 Fig4 Pik3c2a Pik3c3 Vac14 Sacm1l Arf3 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-RNO-111452.1 Activation and oligomerization of BAK protein Bid Bak1 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9034793.1 Activated NTRK3 signals through PLCG1 Ntrk3 Plcg1 Ntf3 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-RNO-69615.1 G1 S DNA Damage Checkpoints Cdc25a Csnk1a1 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Mapk11 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Cdk2 Phf20 Psmb2 Gsk3b Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdkn1b Psmd7 Psmd6 Psmd8 Chek1 Psmd2 Chek2 Csnk1e Rps27a Psmd1 Adrm1 Skp1 Uba52 Fbxw11 Ccne1 Ccne2 Atm Ccna1 Ccna2 Plk3 Btrc Cop1 Ubb Mdm4 Zfp385a Ubc Rbx1 Mapk14 Psmb6l1 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229354 Gap junction assembly Gjc1 Gja1 Gjc2 Gja3 Gja5 Gja4 Gja10 Gja8 Gjb2 Gjb1 Gjd2 Gjb4 Gjb3 Gjd4 Gjd3 Gjb6 Gjb5 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamin B6 activation to pyridoxal phosphate Pdxk Aox1 Pnpo NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 97%10228388 Nucleotide salvage Adk Upp1 Hprt1 Upp2 Dck Pudp Aprt Tk2 Uck1 Ada Uck2 Dguok Gmpr2 Pnp Ampd3 Ampd2 Tymp Ampd1 Cda Gmpr G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events Adcy8 Adcy5 Adcy6 Adcy9 Rgs20 Rgs17 Rgs16 Gnaz Adra2a Adra2c Adra2b Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%10229152 LDL clearance Npc1 Pcsk9 Ldlrap1 Ap2b1 Ldlr Ap2a2 Ap2s1 Ap2a1 Nceh1 Clta Soat2 Cltc Ap2m1 Soat1 Lipa Apob Npc2 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-RNO-170670.1 Adenylate cyclase inhibitory pathway Adcy8 Gnat3 Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Gnal Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%10230048 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Ilk Pxn Itgb1 Parva SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-RNO-9006936.1 Signaling by TGFB family members Itgb3 Prkcz Cdk9 Ncor2 Grem2 Rhoa Bmp10 Acvrl1 Amhr2 Arrb1 Fkbp1a Inha Amh Zfyve16 Cer1 Gdf2 Bmpr1a Bmpr1b Ppm1a Tgif1 Bmpr2 Smad1 Tgif2 Sp1 Ski Bmp2 Tfdp2 Smad4 Tfdp1 Ccnk Ube2d3 Smad9 Atp1b4 Ccnc Acvr2a Ube2d1 Trim33 Rnf111 Inhba Smad2 Smurf2 Smad3 Smurf1 Wwtr1 Acvr2b Usp9x Fstl1 Ccnt2 Smad5 Smad6 Rbl1 Smad7 E2f4 Chrdl1 E2f5 Skil Ube2m Arrb2 Itgb1 Fgf2 Itga8 Tgfbr3 Gipc1 Itgb6 Fst Tgfb1 Psenen Tgfb2 Hdac1 Tgfb3 Cgn Psen1 Bambi Ltbp3 Psen2 Ltbp2 Ltbp4 Ncstn Ltbp1 Itgb8 Aph1a Acvr1c Aph1b Strap Acvr1b Zfyve9 Tgfbr1 Tgfbr2 Men1 Mtmr4 Pard6a Mmp14 Mapk1 Mmp16 Rps27a Mapk3 Inhbb Pard3 Uba52 F11r Furin Stub1 Nedd8 Parp1 Timp1 Timp2 Ubb Ubc Itgav Cbl TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%10228656 Translesion synthesis by REV1 Rev1 Rpa1 Rpa2 Rps27a Rpa3 Rev3l Ubb Ubc Uba52 Rfc5 Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-RNO-2514853.1 Condensation of Prometaphase Chromosomes Csnk2b Csnk2a2 Csnk2a1 Ncapd2 Ncapg Smc4 Ncaph Smc2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-RNO-1793185.1 Chondroitin sulfate dermatan sulfate metabolism Glb1l3 Glb1l2 Hexa Hexb Dcn Chst3 Glb1 Idua Ncan Bcan Bgn Cspg5 Cspg4 Vcan Hyal4 Hyal3 Ids Chst11 Hyal1 Chst12 Gusb Chsy1 Chsy3 Arsb Chst13 Chst14 Chst15 Dse Chpf Csgalnact2 Chst7 Chst9 Dsel Ust Glb1l DUAL INCISION IN GG-NER%REACTOME%R-RNO-5696400.1 Dual Incision in GG-NER Gtf2h5 Pold3 Ercc2 Ercc1 Ercc3 Ercc4 Rps27a Polk Pole3 Pole2 Uba52 Pole4 Rpa1 Rpa2 Ddb1 Cul4a Parp2 Pold1 Rpa3 Parp1 Pold4 Xpa Cul4b Ddb2 Pole Chd1l Ubb Ubc Rbx1 Rfc5 Pold2 Rfc3 Gtf2h2 Gtf2h1 Rfc4 Pcna Rfc1 Gtf2h3 Rfc2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%10231694 Regulation of MITF-M-dependent genes involved in pigmentation Sytl2 Myrip Rab27a Myo5a SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-RNO-9716542.1 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Cenpl Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ndc80 H2ac18 Cul3 Sh3rf1 Ywhae Vhl Stam2 Steap3 Ywhag Hist1h2bq Ctnnb1 Pik3c3 Ppp2r5b Ppp2r5a Dvl1 Dvl3 Als2 Fnbp1 Pik3r4 Ppp2r5e Atp6ap1 H2aj H3-3b Hist3h2ba H2bc18 H2az2 H2bc6 H2bc4 Usp9x Hist1h4m H2bc1 Hist1h2ai Lrrc41 Sptbn1 Ptk2 Sptan1 Grb2 Sos1 Arl13b Vim Rps27 Kdm1a Ndufs3 Ndufa5 Rbbp6 Stom Hsp90aa1 Rhot2 Mfn1 Mfn2 Trak1 Ncf1 Myo19 Ncf2 Trak2 Ncf4 Hsp90ab1 Brk1 Baiap2 Nck1 Nckap1l Nup98 Nckap1 Nup37 Elmo2 Nup107 Prkcz Wasf3 Nup160 Wasf2 Wasf1 Jup Nup85 Abi2 Cyba Abi1 Nup43 Cybb Cyfip2 Aaas Cyfip1 Xpo1 Pdpk1 Ranbp2 Nup133 Lamtor1 Rhoa Ngef Zap70 Flot2 Flot1 Slitrk5 Slitrk3 Lck Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ddx39b Fermt2 Actn1 Ect2 Prex1 Flna Trio Mcf2 Plekhg5 Plekhg2 Htr7 Net1 Rasgrf2 Arhgef10l Ywhaq Ywhah Ywhab Sfn Hnrnpc Pde5a Srrm1 Ppp1cb Clip1 Cdh1 Ctnna1 Iqgap2 Iqgap3 Men1 Ncoa2 Vav1 Pik3r1 Pik3r2 Pik3r3 Cpsf7 Rapgef1 Pik3ca Sos2 Tra2b Ywhaz Ptk2b Cdc25c Rhoc Rhob Lmnb1 Picalm Ocrl Cltc Wipf3 Wipf1 Btk Nckipsd Limk1 Tfrc Cpd Ckb Kdm4c Ppp1r12b Ppp1r14a Ar Ppp1r12a Cftr Lman1 Gja1 Mtr Dbt Itsn1 Itsn2 Hmox2 Myo6 Emd Plk1 Cdc37 Vrk2 Prkcb Rasal2 Diaph1 Snap23 Pard6a Daam1 Pfn1 Mapk1 Vangl2 Golga3 Nudc Mapk3 Rnd2 Muc13 Wdr6 Txnl1 Rac2 Kif14 Scrib Rac3 Rbmx Ptpn13 Nisch Vamp3 Arhgap35 Ppp2cb Dst Depdc1b Ppp2ca Cav1 Fam83b Frs2 Ubxn11 Ccne1 Frs3 Kctd13 Epha2 Kidins220 Ktn1 Arhgap5 Grb7 Plxnd1 Prag1 Arhgap1 Dlg5 Ankrd26 Dsg1 Bltp3b Tnfaip1 Ckap4 Gps1 Ppp2r5d Cct2 Stx5 Ykt6 Trip10 Cenpe Mapk14 Arfgap3 Ppp2r1b Ppp2r1a Mapk11 Klc1 Dync1li2 Rhog Dync1li1 Arhgdib Garre1 Shmt2 Klc4 Klc3 Rac1 Arhgdig Lbr Klc2 Diaph3 Dvl2 Vav3 Cdc42ep1 Pgrmc2 Dock5 Cops4 Dock3 Dock4 Dsg2 Arhgap21 Letm1 Mcam Vav2 Arpc3 Ophn1 Cops2 Stbd1 Pld1 Arhgdia Arpc2 Dock2 Vapb Arhgap32 Pak4 Esyt1 Plekhg3 Mpp7 Arpc5 Ankle2 Itgb3bp Map3k11 Arpc4 Hspe1 Pak1 Spata13 Srgap1 Srgap2 Srgap3 Arhgap45 Gmip AABR07032856.1 Arhgap10 Arhgap17 Bcr Pak2 Dock6 Arhgap4 Fam13b Dock7 Dock8 Arap1 Arap3 Arap2 Arhgap22 Arhgap9 Arhgap20 Prkcd Syde1 Arhgap26 Arhgap24 Cep97 Arhgap29 Osbpl11 Prkca Arhgap27 Pard6b Def6 Rhobtb3 Uaca Myo9b Arhgap6 Arhgap33 Mrtfa Arhgap31 Arhgap8 Arhgap30 Stmn2 Dnmbp Fam91a1 Prex2 Calm3 Mylk Tagap Mtmr1 Dock10 Samm50 Dock11 Fam169a Plekhg1 Baiap2l2 Farp1 Vma22 Ralbp1 Gopc Stard8 Ralgapa1 Itgb1 Dlc1 Wwp2 Stard13 Fam135a Arhgap40 Wdr11 Arhgap44 Tuba1b Arhgap42 Msi2 Cdc42bpa Stip1 Cdc42ep4 Slk Syde2 Phip Pld2 Tpm4 Abl2 Akap12 Slc1a5 Jag1 Stk38 Scfd1 Nox3 Tex2 Nox1 S100a9 S100a8 Swap70 Amigo2 Stk10 Noxa1 Arhgap19 Arhgap15 Arhgap18 Arhgap12 Evl Pafah1b1 Cit Rhobtb2 Rhobtb1 Zw10 Fam13a Baiap2l1 Srf Arhgap25 Arhgap28 Arhgap23 Pcdh7 Csk Fgd5 Prc1 Rnf20 Pak6 Cct6a Pak5 Cdc42bpb Fmnl1 Slc4a7 Git2 Sowahc Aldh3a2 Noxo1 Taok3 Senp1 Chn2 Pfn2 Plekhg6 Tiam1 Twf1 Epsti1 Farp2 Cpne8 Sh3bp1 Pkn2 Nck2 AABR07021573.2 Pkn1 Nipsnap2 Git1 Faf2 Rhoh Abcd3 Rhof Acbd5 Actr2 Anln Rhoj Actb Rhou Actr3 Rhov Arpc1b Arpc1a Rhoq C1qbp Scai Arhgef28 Arhgap11a Emc3 Cct7 Myo9a Ccdc88a Stam Tmem59 Kalrn Mtx1 Cavin1 Tmod3 Arhgef7 Cdc42ep2 Cdc42ep3 Plxna1 Rras2 Rtkn Nsfl1c Rhpn1 Rhpn2 Ccdc187 Basp1 Pak3 Ddrgk1 Lin7b Kif18a Actg1 Maco1 Cdc42 Ddx4 Peak1 Rnd3 Rnd1 Spen Rock2 Armcx3 Rock1 Add3 Ccp110 Rab7a Tor1aip1 Dync1h1 Dlg4 Sema4f Fmnl2 Actc1 Fmnl3 Tmem87a Zfp512b Dync1i2 Dync1i1 Rab9a Abl1 Rab9b Sec13 Racgap1 Clasp1 Clasp2 Spc24 Birc5 Dsp Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Bcap31 Ndel1 Sgo2 Sgo1 Tjp2 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Mapre1 Kif5a Zwint Kif5b B9d2 Ska2l1 H2ab2 Bub1 Ppp1cc Taok1 Nde1 Rcc2 H2ac4 Hgs Kntc1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Cenpq Kif2c Cenpp Vcp Cenpo Cenpn Cenpm Mis12 Zwilch DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%10228132 DNA Replication Pold3 Kpnb1 Kpna6 Kpna1 Cul1 H2ac18 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Psmd12 Pole4 Dbf4 Psmd11 Orc5 Orc4 Hist1h2bq Orc6 Psmd14 Orc1 Psmd13 Orc3 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Rpa1 Rpa2 Cdc7 Psmb7 Cdc6 Psmb6 Psmb1 Prim2 Rpa3 Cdk2 Psmb3 Psmb2 Prim1 Mcm3 Mcm4 H2aj Mcm5 Mcm10 Psma7 Pole Mcm2 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Psmd7 Psmd6 H2az2 Psmd8 Ube2d1 Psmd2 H2bc6 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Hist1h2ai Skp2 Polg2 Twnk Gins2 Gins1 Gins4 Gins3 Ssbp1 Polg Polrmt Dna2 Rps27a Skp1 Uba52 Ube2s Ccne1 Ccne2 Ube2c Cdc27 Cdc26 Ccna1 Cdc23 Ccna2 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Fen1 Lig1 Anapc2 Fzr1 Anapc7 Ube2e1 Pold1 Cdc16 Pold4 H2ab2 Ubb H2ac4 Ubc Rbx1 Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Psmb6l1 Rfc2 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R Igf1 Akt2 Irs1 Irs2 Kl Igf1r Gab1 Flt3 Fgf10 Frs2 Trib3 Fgf3 Fgf22 Fgf7 Pdpk1 Pik3c3 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Them4 Pik3cb Fgfr2 Pde3b Fgf6 Pik3r4 Fgf5 Fgf8 Gab2 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Pik3r1 Pik3r2 Fgfr3 Tlr9 Grb2 Sos1 Fgfr1 Igf2 Ptpn11 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 Fgfrl1 Spred1 Spred2 Ppp2r1a Kl Gab1 Fgf10 Fgf3 Fgf22 Plcg1 Pik3r1 Src Flrt1 Flrt3 Flrt2 Spry2 Mapk1 Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Frs2 Braf Frs3 Mknk1 Shc1 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Pik3ca Nras Ubb Grb2 Ubc Kras Tgfbr3 Sos1 Gipc1 Fgfr1 Hras Cbl Ptpn11 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-RNO-451306.1 Ionotropic activity of kainate receptors Dlg1 Calm3 Grik5 Grik2 Dlg3 Grik1 Grik4 Dlg4 Grik3 Ncald TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-RNO-5357786.1 TNFR1-induced proapoptotic signaling Otud1 Tbk1 Spata2 Rnf31 Usp2 Usp4 Cyld Otud7b Mib2 Ikbke Traf2 Birc2 Tnfrsf1a Fadd Ripk1 Xiap Rbck1 Tradd Sharpin Tnf Usp21 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins Gnas Avp Avpr2 Prkaca Prkacb Aqp1 Prkar1a Prkar1b Gng3 Rab11a Gng5 Gng4 Gng7 Myo5b Gng8 Gngt1 Prkar2a Aqp4 Aqp3 Gnb2 Aqp2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng10-ps1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-RNO-9818027.1 NFE2L2 regulating anti-oxidant detoxification enzymes Prdx1 Srxn1 CO-INHIBITION BY BTLA%REACTOME%R-RNO-9927353.1 Co-inhibition by BTLA Grb2 Btla Ptpn6 Ptpn11 TRANSLATION%REACTOME DATABASE ID RELEASE 97%10228352 Translation Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 AC132020.1 Gadd45gip1 Mrpl20 Ube2d2 Mrpl3 Mrpl4 Psma4 Mrpl1 Psma3 Mrpl2 Psma6 Mrpl9 Mrps18c Psma5 Mrps18b Psma2 Mrps18a Psma1 Cul2 Ptcd3 Eloc Elob Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Ube2d3 Psmd8 Psmd2 Ube2d1 Rpl4 Rps14 Rps15 Psmd1 Rpl5 Rps16 Adrm1 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Kgd4 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eef1d Eif2s1 Eef1a1 Rps6 Rpl24 Eef1b2 Rpl26 Eef1g Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Mt-cyb Ndufab1 Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 Mt-co3 AABR07072440.1 Mt-co2 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rps27a Rpl13 Rpl14 Rpl15 Mt-co1 Rpl17 Mt-nd5 Rpl18 Mt-nd4 Rpl19 Mt-nd6 Uba52 Rpl10 Mt-nd1 Rpl11 Rpl12 Rps3 Mt-nd3 Rps2 Rpl10a Mt-nd2 Rps4x LOC134480579 Ubb Ubc Fau Rpl23a Eif4ebp1 Eif4e Eif5 Eif1ax Eif4a2 Eif4a1 Pabpc1 Eif5b Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Eif2b3 Eif2b2 Eif2b5 Eif2b4 Eif2b1 Ltn1 Trip4 Pelo Ascc3 Ascc2 Hbs1l Nemf Zfp598 Klhdc10 Tcf25 Rchy1 Eef2 Apeh Mief1 Mtrf1l Mt-atp8 Gfm1 Gfm2 Srp68 Mrrf Mt-atp6 Srp9 Mrps9 Mrps2 Mrps7 Mrps5 Mt-nd4l Srp54 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Ppa1 Mrps27 Ppa2 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Rbx1 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Srp14 ENSRNOG00000068816 Eral1 Srp19 Mrpl30 Psmb6l1 Mrpl10 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%10231336 Cristae formation Atp5mg Atp5f1b Atp5f1a Mt-atp6 Atp5po Atp5mk Atp5mc1 Atp5f1e Atp5f1d Atp5pb Atp5f1c Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Mt-atp8 Dmac2l CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%10231072 CD22 mediated BCR regulation Cd22 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Cd79a Ptpn6 Cd79b CHD1 AND CHD2 SUBFAMILY%REACTOME%R-RNO-9943411.1 CHD1 and CHD2 subfamily Cherp Snrpg Snrpb H2bc6 Phf5a H2bc4 Hist1h4m H2bc1 Smndc1 Sf3a1 H2ac18 Sf3a2 Sf3a3 Hist1h2ai U2surp Sf3b1 Snrpd1 Sf3b3 Sf3b4 Sf3b5 Snrpd3 Hist1h2bq Rbm17 Cdc73 Ddx46 Snrpa1 Snrpepl2 Skic8 Chd1 Ddx42 Puf60 Chd2 Ssrp1 Ctr9 Paf1 Leo1 H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2bc18 Snrpf Snrpn Dhx15 H2az2 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions Plxnd1 Sema5a Sema4d Sema4a Trem2 Tyrobp Sema7a Plxna1 Plxnc1 Sema3e Ptprc Cd72 Sema6d Plxnb3 PROTEIN LOCALIZATION%REACTOME%R-RNO-9609507.1 Protein localization Ube2d2 Crot Acox3 Ide Atp5mc3 Hao1 Atp5f1b Ephx2 Phyh Eci2 Mpv17 Hacl1 Gstk1 Sec61gl4 Mlycd Gnpat Acox1 Ech1 Ehhadh Acaa1b Tysnd1 Prnp Coq2 Lonp2 Hao2 Pecr Idh1 Ube2d3 Pitrm1 Decr2 Hspd1 Ube2d1 Nudt19 Acot1 Acot2 Pex1 Acot5 Acot3 Usp9x Acot4 Ldhd Pex7 Pex6 Pex5 Cat Ube2j2 Serp1 Sgta Zfand6 Vapa Cyb5a Agps Nudt7 Hmgcl Pex10 Amacr Hsd17b4 Otc Baat Scp2 Crat Acox2 Acot8 Slc27a2 Nos2 Pipox Fis1 Aldh3a2 Pex2 Abcd1 Pex26 Atad1 Pex14 Abcd2 Pex13 Gdap1 Abcd3 Dao Acbd5 Pex12 Pex3 Pex11b Pxmp4 Pxmp2 Pex19 Pex16 Stx1a Hmox1 Ddo Vamp2 Emd Agxt App Fxn Rps27a Hscb Uba52 Dhrs4 Ndufb8 Stx5 Ubb Ubc INTERLEUKIN-37 SIGNALING%REACTOME%R-RNO-9008059.1 Interleukin-37 signaling Tbk1 Stat3 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-901042.1 Calnexin calreticulin cycle Ubb Ubc Pdia3 Uba52 Canx Rps27a Calr FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230560 FCGR activation ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Syk ENSRNOG00000065564 ENSRNOG00000066971 Fcgr2 ENSRNOG00000063341 Fgr Hck ENSRNOG00000065283 Lyn ENSRNOG00000062976 Yes1 ENSRNOG00000063549 Src ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Cd3g ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Fcgr1a ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Fyn BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism Bckdha Glyat Hsd17b10 Ivd Hibadh Acat1 Crat Dld Mccc1 Acadsb Mccc2 Bckdk Bcat1 Bcat2 Acad8 Auh Aldh6a1 Dbt Hibch Echs1 Bckdhb Ppm1k RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231390 RHOC GTPase cycle Pkn2 Pkn1 Abcd3 Acbd5 Anln Rhoc C1qbp Arhgef28 Jup Cavin1 Rtkn Iqgap3 Lbr Ccdc187 Diaph3 Maco1 Arhgap21 Rock2 Vav2 Mcam Rock1 Ophn1 Arhgdia Fmnl2 Vapb Arhgap32 Fmnl3 Pik3r1 Rhoa Flot2 Flot1 Diaph1 Tfrc Mcf2l Bcr Arhgef17 Daam1 Arhgef11 Arhgef10 Arhgef12 Akap13 Stom Arhgef25 Arhgap26 Arhgef5 Racgap1 Arhgef1 Myo9b Vamp3 Arhgap35 Depdc1b Abr Cav1 Prex1 Dlc1 Stard13 Arhgap5 Mcf2 Arhgap1 Tjp2 Slk Arhgef10l Stk10 Arhgap18 Stx5 Cit Lman1 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10229140 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Ccnc Rnf111 Smad2 Mapk1 Smad3 Wwtr1 Ccnt2 Rps27a Rbl1 E2f4 Smad7 Mapk3 E2f5 Cdk9 Ubb Ubc Uba52 Sp1 Furin Tfdp2 Men1 Smad4 Tfdp1 Ccnk PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism Nudt19 Acbd5 Acot4 Acoxl Crot Acbd4 Acox3 Amacr Hsd17b4 Scp2 Crat Acox2 Phyh Eci2 Acot8 Hacl1 Mlycd Slc27a2 Acox1 Ehhadh Acaa1b Aldh3a2 Hao2 Abcd1 Pecr Decr2 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-RNO-9675108.1 Nervous system development Rhoc Rhob Csnk2a2 Csnk2a1 Clta Gab1 Cltc Dnm1 Grb10 Dnm3 Csnk2b Dnm2 Gsk3b Sh3gl2 Limk1 Met Ranbp9 Spta1 St8sia4 Ptpra Col4a1 Col4a2 Ncam1 Sptbn1 Numb Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Sptbn4 Itga9 Nras Grb2 Fyn Kras St8sia2 Sos1 Hras Itga2b Itsn1 Tln1 Erbb2 Mapk7 Mapk1 Mapk3 Arhgap35 Crmp1 Frs2 Rdx Epha2 Grb7 Ret Rps6ka5 Plxnd1 Cdk5r1 Hsp90aa1 Dscaml1 Adgrg6 Nrp1 Shc3 Tyrobp Dab1 Ap2s1 Hsp90ab1 Pip5k1c Itgav Pdlim7 Ntn4 Nck1 Nfasc Itgb3 Unc5a Vldlr Prkcq Ezr Egfr Sema7a Artn Lypla2 Rac1 Gfra1 Gfra2 Map2k1 Vav3 Gfra4 Plcg1 Vav2 Rras Arpc3 Shank3 Arpc2 L1cam Lyn Yes1 Src Rhoa Dpysl2 Ngef Dpysl3 Dpysl4 Arpc5 Dpysl5 Arpc4 Pak1 Map2k2 Ap2m1 Ptprc Cd72 Pak2 Plxnb1 Plxnb3 Plxna4 Sh3kbp1 Plxna3 Arhgef11 Plxna2 Arhgef12 Dok1 Prkaca Dok2 Prkacb Reln Dscam Dok4 Dok5 Dok6 Prkca Myo9b Pspn Gdnf Msn Plxnc1 Fes Nrtn Trio Itgb1 Sema6d Gap43 Cdk5 Sema5a Sema4d Sema4a Sema3a Fgfr1 Sema3e Tiam1 Farp2 Efna1 Efna2 Nck2 Git1 Sdcbp Ank1 Mmp2 Mmp9 Actr2 Epha1 Epha3 Actb Actr3 Epha4 Arpc1b Arpc1a Epha5 Psenen Arhgef28 Epha6 Epha7 Psen1 Epha10 Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Rasa1 Plxna1 Sdc2 Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Grin1 Pak3 Actg1 Cdc42 Efnb1 Efnb2 Efnb3 Rnd1 Rlc-a Rock2 Rock1 Efna4 Gab2 Efna5 Grin2b Pik3r1 Pik3r2 Pik3r3 Ap2b1 Irs2 Dcc Shc1 Rap1gap Kif4b Kif4a Pik3cb Pik3cd Pik3ca Trem2 Ap2a2 Ap2a1 Ptpn11 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 Psen2 Ncstn Stat5a Aph1a Wwox Aph1b Yap1 Psenen Src Esr1 Psen1 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 97%10231288 ATF6B (ATF6-beta) activates chaperones Atf6b Mbtps1 CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions Cyp2a2 Cyp2a1 Cyp2c66 Cyp2d4 Cyp2c11 Cyp2e1 Cyp2a3 Cyp2s1 Cyp2f2 Cyp2b1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression Kat2b Wwtr1 Yap1 Tead3 Tead2 Tbx5 Tead4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%10229176 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229318 FGFR1b ligand binding and activation Fgf2 Fgf1 Tgfbr3 Gipc1 Fgfr1 Fgf10 Fgf3 Fgf22 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 97%10230624 Abacavir ADME Nt5c2 Slc22a2 Slc22a1 Slc22a3 Adh1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-RNO-9933939.1 Formation of the polybromo-BAF (pBAF) complex Bcl7c Actg1 Actl6a Phf10 Smarce1 Smarcc1 Smarca2 Pbrm1 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Smarca4 Brd7 Bcl7a Bcl7b LXR-MEDIATED SIGNALING%REACTOME%R-RNO-9024446.1 LXR-mediated signaling Abca1 Tbl1x Nr1h3 Nr1h2 Rxrb Hdac3 Rxra Ncor2 Tbl1xr1 Ep300 Gps2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10229498 AKT phosphorylates targets in the nucleus Akt1 Foxo6 Foxo4 Foxo1 Akt3 Rps6kb2 Akt2 Foxo3 Nr4a1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%10231060 Resolution of D-Loop Structures Rad51b Rad50 Bard1 Top3a Palb2 Firrm Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc3 Slx1b Xrcc2 Atm Mus81 Rmi2 Fignl1 Rmi1 Brip1 Mre11 Eme2 Kat5 Eme1 Exo1 Nbn Gen1 Slx4 Dna2 Wrn Rad51c Blm Spidr Rad51 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%10230506 Cysteine formation from homocysteine Cth Cbs INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism Nup58 Nup37 Nup205 Pom121 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Ippk Ipmk Ocrl Nup85 Ip6k1 Ip6k2 Nup42 Nup62 Nup43 Inpp4a Nup88 Inpp4b Aaas Nup214 Ranbp2 Nup155 Nup133 Plcg1 Nup210 Nup153 Plcg2 Pld4 Synj1 Plcb4 Plcb3 Plcb2 Plcb1 Inppl1 Sec13 Calm3 Inpp5d Miox Ip6k3 Isyna1 Itpka Itpkc Itpkb Impa2 Impa1 Inpp5a Inpp5b Plch1 Plcd1 Inpp5j Pten Plcd4 Plcd3 Itpk1 Nudt4 Nudt3 Minpp1 Plcz1 Plce1 Inpp1 Ppip5k1 Ppip5k2 Nup93 Nup50 Nup35 Nup54 Nup98 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 97%10229018 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Tbk1 Irf7 Tlr4 Rps27a Irf3 Ticam2 Ikbke Cd14 Tank Ticam1 Traf3 Ubb Sarm1 Ubc Optn Uba52 Ptpn11 Ly96 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME%R-RNO-111469.1 SMAC, XIAP-regulated apoptotic response Diablol1 Septin4 Xiap Casp7 Casp3 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231164 Regulation of PTEN stability and activity Nedd4 Akt3 Psma4 Psma3 Akt2 Psma6 Psma5 Akt1 Psma2 Tnks2 Psma1 Csnk2a2 Csnk2a1 Psmd12 Psmd11 Psmd14 Rnf146 Psmd13 Tnks Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Mkrn1 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Prex2 Uba52 Xiap Stub1 Wwp2 Pten Ubb Ubc Trim27 Otud3 Usp13 Frk Psmb6l1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230390 Estrogen-dependent gene expression Tbp Gtf2a1 Gtf2a2 Greb1 Cited1 H2ac18 Hdac1 Esr1 Kdm1a Cdk9 Crebbp Pou2f1 Hist1h2bq Prmt1 Fkbp4 Ptges3 Carm1 H2aj Ep300 H3-3b Zfp217 Foxa1 Kat5 Hist3h2ba Ncoa3 Kat2b Yy1 Cbfb Runx1 H2bc18 Nr5a2 Atf2 H2az2 H2bc6 H2bc4 Hist1h4m H2bc1 Hist1h2ai Fos Nrip1 Kdm4b Hsp90aa1 Polr2c Polr2a Polr2b Polr2g H2ab2 Polr2h Polr2e Polr2f Tle3 Polr2i H2ac4 Polr2j Hsp90ab1 Jun Gtf2f2 Pgr Gtf2f1 Gata3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559580.1 Oxidative Stress Induced Senescence Mink1 Map4k4 Mapkapk5 Map2k3 Cdk4 H2ac18 Ezh2 Mapk10 Mapk11 Suz12 Hist1h2bq Tp53 Eed H2aj H3-3b Hist3h2ba Txn H2bc18 Mapk9 H2az2 Kdm6b Mapk8 H2bc6 Mapk1 Rbbp4 H2bc4 Hist1h4m H2bc1 Rps27a Rbbp7 Mapk3 Hist1h2ai Uba52 Ring1 Fos Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Cdk6 Bmi1 Rnf2 Map2k7 Map2k6 H2ab2 Ubb Mdm4 H2ac4 Ubc Mapkapk3 Mapk14 Map3k5 Jun Tnik Mapkapk2 Cdkn2b Cdkn2d PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228304 Propionyl-CoA catabolism Pcca Pccb Mmut Mmaa SIGNALING BY MET%REACTOME DATABASE ID RELEASE 97%10231140 Signaling by MET Hgfac Hpn Rab4b Gga3 Spint2 Spint1 Eps15 Stam Stam2 Rap1b Gab1 Rab4a Rac1 Rap1a Megf11 Lama4 Tns4 Tns3 Sh3gl2 Pik3r1 Src Itga3 Sh3gl3 Sh3kbp1 Dock7 Rps27a Rapgef1 Stat3 Hgf Lrig1 Sh3gl1 Ptpn2 Usp8 Ptpn1 Met Uba52 Shc1 Itgb1 Ranbp9 Ranbp10 Arf6 Pik3ca Ptk2 Nras Ubb Grb2 Ubc Itga2 Kras Hgs Sos1 Crk Hras Cbl Ptpn11 Crkl COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%10230450 Collagen formation P4hb Mmp9 Gpr162 Col14a1 Pxdn Col10a1 Ppib Col1a2 Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Adamts3 Col24a1 Adamts2 Col5a1 Col9a2 Col9a3 Lox Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 Mmp7 P3h2 Mmp3 Adamts14 P3h1 Crtap Pcolce2 Colgalt2 Loxl2 Loxl1 Loxl4 Loxl3 Col2a1 Col27a1 Col4a4 Col6a2 Serpinh1 Col23a1 Col6a5 Col6a6 Col4a5 Col6a3 Col8a1 Col4a6 Col8a2 Col18a1 Bmp1 Plod3 Tll2 Tll1 Plod1 Plod2 Col7a1 Mmp20 Col26a1 Mmp13 Col15a1 Col13a1 Col19a1 Col4a1 Col25a1 Col4a2 Ctsb Ctsl Ctss NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10229574 NOSIP mediated eNOS trafficking Nos3 Nosip INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%10230212 Interferon Signaling Nedd4 Tarbp2 Npm1 Kpnb1 Ppp2r1b Ppp2r1a Kpna1 Fnta Fntb Irf3 Adar Usp18 Chuk Ube2l6 Ppm1b Mx2 Eif2ak2 Arih1 Trim25 Becn1 Isg15 Flnb Ppp2r5a Plcg1 Fkbp5 Tp53 Sphk1 Hspa8 Ifngr2 Ifng Ifngr1 Raf1 Jak2 Prkcd Ptpn2 Ptpn1 Dhx9 Sfn Pde12 Uba7 Rig1 Rnasel Oasl Mapt Actb Actg1 Tyk2 Cdk1 Camk2g Camk2d Camk2b Pim1 Ikbkb Pias1 Gbp5 Ilf2 Ilf3 Ifna4l1 Mapk1 Snca Mavs Faap100 Ikbkg Ifna1l1 Ifi44 Rps27a Hspa2 Mapk3 Dnajc3 Stat3 Ube2n Fancl Stat1 Ifnb1 Socs1 Fancm Socs3 Fanca Fancb Fancc Fance Fancf Ybx1 Fancg Camk2a Ppp2cb Dus2 Ppp2ca Ifna4 Uba52 Ifna1 Irf9 Hspa1b Hspa1a Pggt1b Ifnar1 LOC120103158 Furin LOC120103159 Hspa1l Ifnar2 Gbp2 Gbp1 Gbp3 Faap24 Faap20 Ifi44l Ube2e1 Map2k6 Ubb Ubc Sumo1 Ptpn6 Ptpn11 Nck1 Prkra Casp1 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria Bmf Mapk8 Dynll2 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%10229014 The fatty acid cycling model Slc25a27 Ucp1 Ucp2 Ucp3 Slc25a14 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%10228892 Amplification and propagation of coagulation cascade F10 F11 Gp5 Gp9 F9 Gp1bb Pros1 Gp1ba F2 Proc F8 Serpina5 Serpinc1 Ano6 Serpine2 Serpind1 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10230054 Intracellular metabolism of fatty acids regulates insulin secretion Acsl3 Acsl4 Cd36 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 97%10228332 Glycogen breakdown (glycogenolysis) Pgm1 Phkg1 Calm3 Phkg2 Gaa Agl Pygl Pygm Phkb Akr1e2 Phka1 Phka2 Gyg1 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-RNO-9958790.1 SLC-mediated transport of inorganic anions Slc26a9 Slc20a2 Slc26a11 Slc20a1 Slc26a7 Ahcyl2 Slc17a1 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc4a9 Slc13a4 Slc13a1 Slc34a3 Slc4a10 Slc4a1 Slc5a5 Slc12a1 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 Slc34a1 Slc5a8 Slc34a2 Slc4a7 Slc26a2 Slc26a1 Slc26a6 Slc26a4 Slc26a3 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%10228672 SLBP independent Processing of Histone Pre-mRNAs Lsm11 Zfp473 Snrpg Snrpb Ncbp2 Snrpepl2 Ncbp1 Snrpf Snrpd3 Lsm10 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10228810 Ion homeostasis Atp2a1 Atp2b1 Atp2b4 Atp2a3 Atp2b3 Prkaca Atp2a2 Clic2 Dmpk Itpr3 Atp1a2 Camk2a Itpr2 Fxyd3 Fxyd4 Calm3 Asph Slc8a1 Atp1a1 Atp1a4 Fxyd1 Fxyd2 Slc8a2 Atp1a3 Fxyd7 Fxyd6 Ahcyl1 Pln Tnni3 Ryr2 Slc8a3 Ryr1 Fkbp1b Stim1 Adam22 Trdn Abcc9 Trpc1 Atp1b1 Atp1b3 Nos1 Atp1b2 Kcnj11 Camk2g Camk2d Itpr1 Camk2b POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%10229222 Polymerase switching on the C-strand of the telomere Pold3 Pola2 Pola1 Chtf8 Terf2 Terf1 Tinf2 Chtf18 Ctc1 Stn1 Acd Prim2 Pold1 Terf2ip Ten1 Dscc1 Prim1 Pot1 Pold4 Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%10228752 Cytochrome c-mediated apoptotic response Cycsl2 Diablol1 Mapk1 Casp9 Apaf1 Xiap Apip Casp7 Mapk3 Cycs Casp3 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-RNO-8932505.1 DAG1 core M3 glycosylations Pomgnt2 Dag1 Pomt1 B3galnt2 Pomt2 Pomk MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy Prkag1 Chmp2b Dynll1 Prkag2 Dynll2 Ube2d2 Csnk2a2 Dync1li2 Csnk2a1 Chmp3 Dync1li1 Atg7 Chmp7 Becn1 Pik3c3 Chmp6 Csnk2b Lamtor5 Pik3r4 Rptor Lamtor3 Gabarapl2 Rraga Lamtor4 RragB Lamtor1 Src Rragc Atg3 Lamtor2 Mtmr14 Rragd Rb1cc1 Pcnt Map1lc3a Uvrag Fundc1 Mtor Atg10 Pgam5 Pink1 Rheb Atg13 Atg5 Tomm7 Atg14 Atg12 Tomm40 Tomm22 Gabarapl1 Mlst8 Slc38a9 Tomm20 Mtmr3 Vdac2 Atg9b Vdac3 Atg101 Vdac1 Ambra1 Tomm70 Ube2d3 Wdr45b Atg9a Wdr45 Usp30 Mterf3 Atg16l2 Atg16l1 Wipi2 Wipi1 Atg4b Atg4c Atg4a Atg4d Nbr1 Park7 Pex5 Prkab2 Prkab1 Map1lc3b Chmp4c Cftr Arl13b Tbk1 Ulk1 Optn Gabarap Dync1h1 Dync1i2 Dync1i1 Prkn Rps27a Ube2l3 Ube2n Sqstm1 Uba52 Atm Tsc2 Tsc1 Mfn1 Prkaa1 Mfn2 Ubb Chmp4bl1 Ubc Prkag3 Chmp2a PROTEIN LIPOYLATION%REACTOME%R-RNO-9857492.1 Protein lipoylation Dlst Gcsh Ndufab1 Dbt Dlat Lipt1 Lipt2 Nfu1 Lias Fdx1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228522 Triglyceride biosynthesis Gk Lpin3 Gpam Lpin2 Dgat1 Agmo Mogat1 Gpat2 Mogat2 Gykl1 Dgat2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME DATABASE ID RELEASE 97%10231096 Gap-filling DNA repair synthesis and ligation in TC-NER Pold3 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Polk Xab2 Pole3 Pole2 Pole4 Ppie Rpa1 Rpa2 Rpa3 Prpf19 Pole Lig3 Rps27a Znf830 Isy1 Aqr Uba52 Usp7 Uvssa Xrcc1 Tcea1 Ercc6 Ddb1 Lig1 Cul4a Pold1 Polr2c Polr2a Pold4 Polr2b Cul4b Polr2g Polr2h Polr2e Polr2f Mnat1 Ubb Polr2i Ubc Polr2j Rbx1 Rfc5 Pold2 Rfc3 Gtf2h2 Rfc4 Gtf2h1 Pcna Rfc1 Rfc2 Gtf2h3 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 97%10228572 Beta oxidation of octanoyl-CoA to hexanoyl-CoA Hadha Echs1 Acadm Hadhb Hadh OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%10231562 Oleoyl-phe metabolism Pm20d1 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%10229692 Biosynthesis of Lipoxins (LX) Hpgd Alox5 Ltc4s Alox5ap Alox12 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 97%10228220 DNA Double Strand Break Response Rad50 Eya2 Eya1 Eya4 Babam1 Eya3 Babam2 Ubxn1 Psma4 Psma3 Brca1 Psma6 Psma5 Uimc1 Psma2 Psma1 Psmd12 Psmd11 Hist1h2bq Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Psmb2 Pias4 Mre11 Psma7 Ube2i Psmc5 Kat5 Hist3h2ba Psmc2 Psmc1 Nbn Psmc4 Psmc3 Psmd7 Psmd6 Baz1b Psmd8 Psmd2 Mapk8 Chek2 H2bc6 Ube2v2 H2bc4 Bard1 Hist1h4m H2bc1 Rps27a Abl1 Psmd1 Ube2n Adrm1 Kpna2 Uba52 Atm Bap1 Tp53bp1 Ppp5c Apbb1 Phf6 Kdm4b Kdm4a Ddb1 Cul4a Cul4b Brcc3 Smarca5 Herc2 Ubb Rnf168 Sumo1 Ubc ABRAXAS1 Rbx1 Rnf8 Nsd2 Psmb6l1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation Nfkbia Prkcq Cul1 Tab3 Ube2d2 Tab2 Tab1 Psma4 Psma3 Psma6 ENSRNOG00000069193 Chuk AABR07065813.1 Psma5 ENSRNOG00000062915 Psma2 Igll1 Psma1 Cdc34 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 Psmd12 ENSRNOG00000070810 ENSRNOG00000066926 Psmd11 ENSRNOG00000066406 Pdpk1 Psmd14 ENSRNOG00000067897 ENSRNOG00000062685 Psmd13 ENSRNOG00000070192 Psmb5 Iglc1 Psmb4 ENSRNOG00000070159 ENSRNOG00000071049 Psmb7 Psmb6 AABR07034736.1 Psmb1 ENSRNOG00000065564 Psmb3 ENSRNOG00000066971 Psmb2 ENSRNOG00000063341 ENSRNOG00000070986 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Psma7 Igkvl13 Psmc5 AABR07065812.2 Psmc2 ENSRNOG00000063707 ENSRNOG00000067679 Psmc1 Psmc4 ENSRNOG00000070832 Psmc3 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 Psmd7 Psmd6 Psmd8 ENSRNOG00000064490 Ube2d1 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Psmd1 Adrm1 Ikbkb Traf6 Ikbkg Rps27a Map3k7 Ube2n Bcl10 Nfkb1 Skp1 Uba52 Fbxw11 Rela Malt1 Btrc Ubb Ubc Psmb6l1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10231502 NOTCH4 Activation and Transmission of Signal to the Nucleus Ywhaz INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-RNO-8854521.1 Interaction between PHLDA1 and AURKA Aurka Phlda1 DEGRADATION OF AXIN%REACTOME%R-RNO-4641257.1 Degradation of AXIN Psmd8 Psmd2 Smurf2 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Tnks2 Psma1 Axin2 Uba52 Psmd12 Psmd11 Psmd14 Rnf146 Psmd13 Tnks Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Axin1 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 EXTENSION OF TELOMERES%REACTOME%R-RNO-180786.1 Extension of Telomeres Pold3 Pola2 Pola1 Chtf8 Terf2 Terf1 Tinf2 Rpa1 Chtf18 Rpa2 Ppp6r3 Ctc1 Stn1 Prim2 Tert Acd Terf2ip Rpa3 Ten1 Cdk2 Dscc1 Prim1 Pot1 Dna2 Blm Ppp6c Ankrd28 Ccna1 Ccna2 Shq1 Dkc1 Nhp2 Pif1 Fen1 Gar1 Lig1 Wrap53 Nop10 Rtel1 Pold1 Pold4 Rfc5 Pold2 Rfc3 Rfc4 Wrn Pcna Rfc1 Rfc2 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%10228424 Inactivation, recovery and regulation of the phototransduction cascade Fnta Fntb Nmt1 Calm3 Pde6a Pde6b Gngt1 Rgs9bp Ppef1 Metap1 Rho Metap2 Cnga1 Gnb5 Grk1 Grk4 Rgs9 Camkmt Cngb1 Gnat1 Gucy2e Rcvrn Nmt2 Sag Guca1b Guca1a Gucy2f Pde6g COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%10230678 Cohesin Loading onto Chromatin Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Nipbl Mau2 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%10231772 Transcriptional regulation of multiciliogenesis Grhl1 Gmnn Tp73 E2f4 E2f5 Grhl3 Gmnc Tfdp1 Mcidas Grhl2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-RNO-69656.1 Cyclin A:Cdk2-associated events at S phase entry Cables1 Cdc25b Cdc25a Ccnh Skp2 Ccnd1 Cdk4 Rb1 Cdk7 Cul1 Akt3 Psma4 Psma3 Akt2 Psma6 Psma5 Akt1 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cdk2 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ptk6 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ccne1 Ccne2 Ccna1 Ccna2 Cks1b Fzr1 Mnat1 Ubb Ubc Wee1 Psmb6l1 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%10231610 Regulation of CDH11 Expression and Function Jup Zeb2 Cdh11 Adam19 Ctnnd1 Amot Sp1 Ctnnb1 Angptl4 SIGNALING BY FGFR4%REACTOME%R-RNO-5654743.1 Signaling by FGFR4 Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Gab1 Frs2 Braf Frs3 Mknk1 Shc1 Fgf16 Fgf17 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Src Pik3r1 Nras Ubb Grb2 Ubc Kras Sos1 Hras Cbl Ptpn11 TCR SIGNALING%REACTOME%R-RNO-202403.1 TCR signaling Nfkbia Prkcq Cul1 Ube2d2 Tab2 Psma4 Psma3 Psma6 Chuk Psma5 Psma2 Psma1 Cdc34 Psmd12 Psmd11 Pdpk1 Psmd14 Psmd13 Trat1 Pak3 Plcg1 Psmb5 Psmb4 Plcg2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Pik3r1 Psma7 Pik3r2 Lcp2 Zap70 Psmc5 RT1-Db2 Psmc2 Cd247 Psmc1 Cd3g Psmc4 Pak1 RT1-Db1 Psmc3 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Ptprc Psmd7 Ptpn22 Ikbkb RT1-Ba Pak2 Psmd6 RT1-Bb Pag1 Grap2 ENSRNOG00000065955 Psmd8 Ube2d1 Trbv16 Psmd2 RT1-Da Traf6 Ikbkg Rps27a Lat Map3k7 Psmd1 Ube2n Adrm1 Bcl10 Nfkb1 Fyb1 Skp1 Itk Uba52 Fbxw11 Inpp5d Rela Malt1 Btrc Pik3cb Pik3ca Pten Cd101 Ubb Ripk2 Ubc Csk Nck1 Psmb6l1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 97%10229380 Sterols are 12-hydroxylated by CYP8B1 Cyp8b1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) Shc2 Nab2 Ppp2r1b Dnal4 Ppp2r1a Chd4 Egr2 Mapk11 Clta Ntrk1 Ngf Cltc Map2k1 Ralgds Rap1a Sh3gl2 Pik3r1 Rhoa Pik3r2 Map2k2 Ap2m1 Atf1 Mapk7 Mapk1 Rapgef1 Mapk3 Sgk1 Ap2b1 Irs1 Irs2 Ppp2cb Ppp2ca Frs2 Braf Vrk3 Shc1 Kidins220 Rps6ka3 Rps6ka5 Rps6ka1 Rps6ka2 Pik3cb Pik3ca Ppp2r5d Ywhab Shc3 Dusp3 Dusp4 Nras Srf Grb2 Ap2a2 Ap2a1 Kras Ap2s1 Sos1 Dusp7 Crk Dusp6 Hras Mapkapk3 Mapk14 Mapkapk2 Crkl UBIQUINOL BIOSYNTHESIS%REACTOME%R-RNO-2142789.1 Ubiquinol biosynthesis Pdss2 Coq8a Coq8b Pdss1 Coq3 Coq4 Coq5 Coq6 Hpdl Coq7 Coq9 Stard7 Coq2 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-RNO-9840373.1 Cellular response to mitochondrial stress Eif2s3 Eif2s2 Eif2s1 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Oma1 RAP1 SIGNALLING%REACTOME%R-RNO-392517.1 Rap1 signalling Sipa1 Rap1a Raf1 Prkaca Prkacb Rap1gap2 Ywhab Rap1b Prkg1 Ywhaz Rapgef4 Rapgef3 Rasgrp1 Rasgrp2 Rap1gap TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-RNO-1299287.1 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism Upp1 Upp2 Nt5c Upb1 Nt5c1a Nt5c3a Nt5e Dpys Tymp Dpyd Nt5m SIGNALING BY FGFR%REACTOME%R-RNO-190236.1 Signaling by FGFR Fgfrl1 Spred1 Spred2 Ppp2r1a Ncbp2 Ncbp1 Kl Hnrnph1 Gab1 Fgf10 Fgf3 Fgf22 Fgf7 Rbfox2 Esrp2 Plcg1 Esrp1 Tial1 Tia1 Galnt3 Fgfbp3 Fgfbp1 Pik3r1 Src Fgfr3 Flrt1 Flrt3 Flrt2 Spry2 Mapk1 Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Frs2 Braf Frs3 Mknk1 Shc1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Polr2c Pik3ca Klb Polr2a Ptbp1 Fgf19 Polr2b Fgfr4 Polr2g Polr2h Hnrnpa1 Polr2e Nras Polr2f Ubb Grb2 Polr2i Hnrnpf Ubc Kras Polr2j Tgfbr3 Sos1 Gipc1 Fgfr1 Hras Cbl Ptpn11 Gtf2f2 Gtf2f1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint Psmd8 Psmd2 Chek2 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Ccne1 Psmd12 Ccne2 Psmd11 Atm Ccna1 Psmd14 Ccna2 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Cdk2 Phf20 Psmb2 Psma7 Psmc5 Cop1 Ubb Mdm4 Psmc2 Zfp385a Psmc1 Ubc Psmc4 Psmc3 Cdkn1b Psmd7 Psmd6 Psmb6l1 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations Sult2a1 Sult2a6 Cyp24a1 Podxl2 Ces2h Mat2a Mat2b Ugp2 Aldh1b1 Bphl Gstm4 Mtrr Cyp2c66 Cyp2c11 Cyp2e1 Cyp1a1 Cyp1a2 Gstk1 Gsto1 Gsto2 Ahcy Aoc1 Fmo1 Cyp2s1 Cyb5r3 Glyat Mtr Gsta5 Gstz1 Smox Ugt1a1 Ces1d Slc35d1 Mat1a Acss2 Tbxas1 Hpgds Ptgis Cyp26b1 Hsp90ab1 Rxra Cyp26a1 Adh4 Adh1 Ptgs1 Cyb5b Ptges3 Cyp26c1 Cyp3a9 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Aldh1a1 Pomc Cyp2j16 Cyp4f39 Adh7 Maoa Cyp2j3 Cyp4f1 Cyp2f2 Cyp4a14 Cyp2b1 Cyp4f3 Cyp4f40 Cyp4a12 Cyp4b1 Cyp2a2 Cyp4f4 Cyp4a10 Cyp2a1 Cyp2d4 Cyp4a2 Cyp2a3 Comt Arnt Ahr Cyp39a1 Cyp19a1 Ncoa2 Cyp11a1 Cyp1b1 Ahrr Cyp2u1 Cyp51a1 Uxs1 Cyp8b1 Sult1c2 Cyp7b1 Nr1h4 Bpnt2 Bpnt1 Cyp4v2 Glyatl3 Cyp21 As3mt Cyp46a1 Cyp2w1 Cyp27a1 Sult1b1 Arnt2 Ugt1a6 Cyp11b1 Fdx1 Ugt1a7 Ugt1a8 Cyp11b3 Chac1 Cyp11b2 Chac2 Fdxr Fdx2 Gstm7 Adh6 Cyp7a1 Aldh2 Gstm5 Adh5 Gstm1 Cyp27b1 Gstm2 Acsm2 Acsm4 Acsm5 Sult1a1 AC114845.1 Ugt2b7 Cmbl Ephx1 Akr1a1 Acy3 Aldh3a1 Aadac Sult6b1 Ugt2a1 Ugt2a3 Ugt2b1 Ugdh Maob Gstp1 Gsta6 Gsta3 Acy1a Gsta1 Gsta2 Ugt3a1 Cbr3 Sult1e1 Aoc3 Nqo2 Gss Fmo3 Fmo2 Cyp2c24 Tpst1 Tpst2 Akr7a3 Akr7a2 Abhd14b Ggt1 Sult4a1 Ugt2b34l1 Ugt2b Ugt2b17 Gstt2 Ugt2b15 Gstt1 Dpep1 Dpep2 Ggct Gclc Esd Cndp2 Gclm Abhd10 Ggt5 Ggt7 Ggt6 Tpmt Nat1 Nat2 Nat3 Ugt2b37 Oplah Sult2b1 Acss1 Mtarc2 Mgst3 Mgst2 Mgst1 Sult2a2 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%10231526 FOXO-mediated transcription of cell cycle genes Foxg1 Smad2 Foxo4 Smad3 Foxo1 Smad4 Foxo3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME%R-RNO-73762.1 RNA Polymerase I Transcription Initiation Gtf2h5 Tbp Ercc2 Ccnh Rbbp4 Ercc3 Rbbp7 Cdk7 Chd4 Hdac2 Taf1d Rrn3 Taf1a Hdac1 Taf1c Taf1b Mta1 Mta2 Mta3 Mbd3 Polr1b Polr1c Polr1a Polr1f Polr1g Polr1e Polr1h Chd3 Ercc6 Ubtf Gatad2a Gatad2b Polr2h Polr2e Polr2f Mnat1 Ttf1 Gtf2h2 Gtf2h1 Gtf2h3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 97%10230032 Deadenylation-dependent mRNA decay Dcps Edc3 Exosc9 Edc4 Nt5c3b Exosc8 Patl1 Exosc5 Skic3 Hbs1l Skic2 Exosc4 Skic8 Exosc7 Lsm3 Exosc6 Lsm5 Exosc1 Paip1 Dcp1b Exosc3 Lsm1 Pan2 Exosc2 Pan3 Lsm6 Dcp2 Lsm7 Dcp1a Eif4a3 Ddx6 Dis3 Eif4e Eif4a2 Eif4a1 Pabpc1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse Erbb2 Arhgef11 Rnd1 Arhgef12 Rock2 Rock1 Rhoc Rhob Sema4d Plxnb1 Rhoa SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-RNO-433137.1 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a4 Slc13a1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-RNO-8939246.1 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Crebbp Cbfb Runx1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase Fbxo5 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cdk2 Psmb2 Ccnb1 Psma7 Plk1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Btrc Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability Akt3 Akt2 Akt1 Jup Mapkap1 Calm3 Cav1 Ctnnd1 Trib3 Ctnna1 Pdpk1 Rac1 Ctnnb1 Pak3 Vav3 Them4 Hsp90aa1 Vav2 Vav1 Nos3 Prr5 Mtor Pak1 Rictor Mlst8 Pak2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%10229946 ADP signalling through P2Y purinoceptor 1 Gna11 Gna14 Pla2g4a Mapk14 Gnaq Src P2ry1 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%10231602 Ribavirin ADME Slc28a3 Adk Itpa Slc28a2 Slc29a1 Nt5c2 Nme1 Ada Pnp Nme2 Slc29a3 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) Adgre5 Adgre1 Pth2 Vipr2 Glp2r Vipr1 Adm2 Pthlh Iapp Adm Ramp1 Vip Calcr Ucn2 Ucn3 Gng10-ps1 Crhr2 Calcb Crhr1 Calca Gipr Gnas Calcrl Pth1r Gng3 Sct Pth Ucn Gng5 Gcgr Gng4 Sctr Gng7 Cd55 Gng8 Gngt1 Adcyap1 Crhbp Gnb2 Ghrh Gnb1 Gnb4 Pth2r Gnb3 Gnb5 Gng11 Gng12 Gip Ghrhr Gcg Glp1r Crh Ramp3 Ramp2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 97%10228570 Beta oxidation of hexanoyl-CoA to butanoyl-CoA Acads Hadha Echs1 Hadhb Hadh MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%10228970 Mitotic Metaphase and Anaphase Cenpl Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ndc80 Lmna Psma4 Lmnb1 Psma3 Psma6 Psma5 Psma2 Psma1 Chmp3 Psmd12 Psmd11 Chmp7 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Chmp6 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Psma7 Psmc5 Tubal3 Psmc2 Rcc1 Psmc1 Spast Psmc4 Espl1 Psmc3 Ppp2r2a Tuba4a Tuba3b Tubb4b Tubb4a Tuba1a Psmd7 Tuba1c Psmd6 Cc2d1b Tubb2b Psmd8 Tubb2a Psmd2 Ist1 Ube2d1 Sirt2 Tuba8 Tubb6 Tubb3 Tubb1 Ran Psmd1 Adrm1 Hdac8 Rps27 Emd Ccnb2 Ccnb1 Plk1 Vrk1 Vrk2 Banf1 Cdk1 Ccnb2-ps2 Rps27a Nudc Ppp2cb Ppp2ca Uba52 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ppp2r5d Chmp4bl1 Ubb Ubc Nup93 Cenpe Nup35 Nup98 Chmp2a Chmp2b Nup37 Nup205 Ppp2r1b Kpnb1 Ppp2r1a Pom121 Nup107 Nup188 Nup160 Ndc1 Nup85 Dync1li2 Nup43 Dync1li1 Xpo1 Ranbp2 Lbr Nup155 Nup133 Ankle2 Itgb3bp Vps4a Chmp4c Tuba1b Pafah1b1 Cdca5 Zw10 Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Fbxo5 Pttg1 Clip1 Kif18a Dync1h1 Ube2i Dync1i2 Dync1i1 Sec13 Clasp1 Clasp2 Spc24 Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Sumo1 Kntc1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Cenpq Kif2c Cenpp Cenpo Cenpn Cenpm Mis12 Psmb6l1 Zwilch SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%10230644 Signaling by NOTCH3 Jag2 Jag1 Rps27a Dll1 Dll4 Psenen Egfr Psen1 Egf Psen2 Ubb Ncstn Ybx1 Aph1a Ubc Aph1b Uba52 Notch3 Adam10 Wwp2 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-RNO-205043.1 NRIF signals cell death from the nucleus Traf6 Rps27a Psenen Ngfr Psen1 Psen2 Itgb3bp Ubb Ncstn Sqstm1 Aph1a Ubc Aph1b Uba52 Ngf TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-RNO-69560.1 Transcriptional activation of p53 responsive genes Zfp385a Tp53 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 97%10231458 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Gstm4 Ltc4s PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-RNO-3214841.1 PKMTs methylate histone lysines Setd1b Rbbp5 Rbbp4 Setd1a Hist1h4m Rbbp7 Kmt2a Kmt2c Suv39h1 Suv39h2 Ezh2 Smyd2 Kmt2d Smyd3 Nfkb2 Setd3 Nfkb1 Kmt5a Nsd3 Kmt2b Setd2 Setd7 Kmt5c Setdb2 Setd6 Nsd1 Aebp2 Mecom Prdm16 Kmt5b Suz12 Rela Prdm9 Dot1l Ash1l Ehmt1 Wdr5 Ash2l Setdb1 Atf7ip Eed H2bc18 Nsd2 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation Ager Nkiras2 Nfkbia Hmgb1l2 Hmgb1l1 Ikbkg S100b Nfkb2 Nfkb1 Chuk Hmgb1-ps34 Nfkbib Nkiras1 App Rela Ikbkb PTK6 DOWN-REGULATION%REACTOME%R-RNO-8849472.1 PTK6 Down-Regulation Ptk6 Ptpn1 Srms SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 97%10230470 Synthesis of PE Pcyt2 Lpin3 Etnk2 Lpin2 Cept1 Etnk1 Etnppl Chka Chkb Selenoi Phospho1 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling Il23r Il27 P4hb Crlf1 Il23a Vamp7 Tyk2 Jak2 Ebi3 Stat3 Stat1 Il12rb1 Il12rb2 Il6st Canx Il12b Il12a REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-RNO-9968551.1 Regulation of GBP-mediated host defense Gbp1 Gbp3 Pim1 Sfn Casp1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%10230828 SUMOylation of RNA binding proteins Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Ring1 Nup62 Nup43 Phc2 Nup88 Aaas Phc1 Nup214 Cbx4 Ranbp2 Cbx2 Phc3 Nup155 Nup133 Nup210 Nup153 Bmi1 Pcgf2 Rnf2 Nop58 Ube2i Hnrnpc Sumo1 Hnrnpk Sumo3 Nup93 Nup50 Nup35 Nup54 Nup98 HEMOSTASIS%REACTOME%R-RNO-109582.1 Hemostasis Kif3a Kif3b Kif3c Sell Kif21a Kif21b Ppp2r5b Ppp2r5a Ppp2r5e Kif20a Kif20b Kifap3 H3-3b Egf Cd36 Tuba4a H2bc18 Hgf Ptpn1 Phactr2 Stxbp3 Selplg Tfpi Alb Ptk2 Vti1b Chid1 Prkch Gata5 Nras Gata4 Grb2 Prtn3 S100a10 Fyn Gpc5 Cfd Kras A1bg Gp6 Sos1 Glg1 Serping1 Hras Pdgfa Pdgfb Clu Nfe2 Ehd1 Ehd2 Islr Ehd3 Pcyox1l Hrg Rbsn Jmjd1c Olr1 Mgll F3 F7 Lhfpl2 Gas6 Sytl4 Hdac2 Ly6g6f Ahsg Spp2 Hdac1 Jam3 Jam2 Serpina3n F12 Kdm1a Timp3 Serpinb6a Grb14 Fam3c Mpig6b Dgka Serpinf2 Dgkb Abhd6 Dgkd Dgke Dgkg Akap10 Ak3 Anxa5 Anxa2 Qsox1 Maff Mafg Brpf3 Esam Lgals3bp Dgkh Dgki Dgkk Lamp2 Dgkq Serpina10 Cd177 Dgkz Wdr1 Daglb Maged2 Endod1 Serpinb2 Serpina4 Dagla Habp4 Cd244 Cdc37l1 Mertk Tagln2 Sh2b2 Sh2b1 Ano6 Thbd Ano5 Itih4 Itih3 Nhlrc2 Rcor1 Mif Zfpm2 Fermt3 Lefty2 Thbs1 Manf Lefty1 Pafah2 Apoh Igf1 Gtpbp2 Orm1 Ecm1 Cd74 Ola1 Ctsw Akap1 Actn4 Cd48 Cd47 Tmsb4x Cd63 F11r Tor4a Clec1b Procr Epcam Tmx3 Fcer1g Pdpn Scg3 Vcl Sele Selp Jchain Cyrib Abhd12 Cbx5 Sccpdh Plat Sirpa Plau Srgn Pecam1 Angpt1 Angpt2 Angpt4 Proz Aplp2 Mfn1 Fcamr Mfn2 Mmrn1 Hmg20b Cd9 Plek Sod1 Tek Itgav Gata3 Itgb3 Bcar1 Vegfa Vegfd Vegfc Vegfb Aldoa Pdpk1 Cyb5r1 Rap1a Slc7a11 Itga6 L1cam Lyn Yes1 Slc7a10 Spn Src Itga3 Rhoa Ppil2 Slc16a3 Slc16a8 Ppia Slc7a6 Slc7a7 Atp1b1 Atp1b3 Atp1b2 Slc16a1 Slc7a8 Prkce Slc7a9 Lck Pik3r5 Pik3r6 Pik3cg Raf1 Jak2 Dok2 Gna13 Slc8a1 Actn1 Slc8a2 Flna Slc8a3 Adam22 Pde10a Pde11a Nos3 Nos2 Prkg2 Pde5a Pde9a Prkg1 Tbxa2r Pde2a Nos1 Ppbp Irag1 Itpr1 Stxbp2 Sparc Tgfb1 Tgfb2 Tgfb3 Smpd1 Sdc1 Syk Vav1 Pik3r1 Pik3r2 Pik3r3 Stx4 Igf2 Bsg Plg Klkb1 Inpp5d Shc1 Cd44 Pik3cb Timp1 Pik3ca Pf4 Mmp1b Crk A2m Ywhaz Ptpn6 Ptpn11 P2ry12 Rhob Adra2a Adra2c Adra2b Fgr Arrb1 Kng1 Gata6 Atp2a1 Atp2b1 Atp2b4 Atp2a3 Atp2b3 Sdc4 Atp2a2 Sdc3 Lrp8 P2rx7 P2rx6 P2rx5 P2rx4 Trpc7 P2rx3 Gpc1 P2rx2 Gpc3 P2rx1 Gpc2 Trpc3 Itpr3 Gpc4 Itpr2 Gpc6 Slc7a5 Agrn F2r F13a1 Arrb2 F2 Proc Serpina5 F2rl2 Serpinc1 F2rl3 Serpine2 Serpind1 F13b Abcc4 Apoa1 Itgax Itpk1 Ptgir Psap Serpine1 P2ry1 Akt1 Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rapgef4 Rapgef3 Rasgrp1 Rasgrp2 Tln1 Slc3a2 Prkcb App Kifc1 Kifc2 Mapk1 Mapk3 Rab27b Rac2 Zfpm1 Gata1 Ppp2cb Gata2 Ppp2ca Cav1 F8 Grb7 F10 Ppp2r5d F11 Gp5 Gp9 F9 Gp1bb Pros1 Gp1ba Cenpe Mapk14 Prkcq Ppp2r1b Ppp2r1a ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Klc1 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Rab5a ENSRNOG00000070415 Rhog ENSRNOG00000070810 ENSRNOG00000066926 Klc4 ENSRNOG00000066406 Klc3 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Klc2 Vav3 ENSRNOG00000070192 Plcg1 Dock5 Iglc1 Dock3 Plcg2 Dock4 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Vav2 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 Dock2 ENSRNOG00000065283 Mag ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Lcp2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Pla2g4a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 Gng10-ps1 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 Dock6 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 Dock7 ENSRNOG00000069901 Dock8 Aamp ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Prkaca Lat Prkacb Prkcg ENSRNOG00000067643 Prkcd Gnai2 Gnai1 Prkca Gnai3 Serpina1 Gna11 Prkar1a Gna14 Prkar1b Calm3 Gng3 Dock10 Dock11 Gng5 Gng4 Itgb1 Gnaq Gng7 Vps45 Gng8 Gngt1 Gnat3 Prkar2a Pde1b Gnb2 Pde1a Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Actn2 Pcdh7 Csk AABR07021573.2 Cd109 Sdc2 Apob Kif18a Actg1 Cdc42 Kif18b Kif19 Tf Plaur Kif11 Kif12 Ceacam1 Kif15 Kif1c Kif1a Kif1b Kif6 Rad51c Kif9 Rad51b Kif22 Kif23 Kif28 Kif27 Kif16b Cxadr Racgap1 Jaml Kif4b Kif26b Kif4a Itga4 Kif26a Itgal Itgb2 Kif5a Kif5b Trem1 Kif13b Kif2a Kif2b Kif2c SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-RNO-1855204.1 Synthesis of IP3 and IP4 in the cytosol Ocrl Calm3 Inpp5d Plcg1 Itpka Plcg2 Itpkc Itpkb Pld4 Synj1 Inpp5b Plch1 Plcd1 Inpp5j Pten Plcd4 Plcd3 Itpk1 Plcb4 Plcb3 Plcz1 Plce1 Plcb2 Plcb1 Inppl1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-RNO-9623433.1 LXRs regulate gene expression to control bile acid homeostasis Nr1h3 Nr1h2 Rxrb Rxra Ncor2 INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling Map2k3 Ppp2r1b Ppp2r1a Cul1 Tab3 Tab2 Tab1 Chuk Mapk10 Mapk11 Mapk9 Atf2 Ikbkb Atf1 Mapk7 Mapk8 Traf6 Mapk1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Nfkb1 Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Rps6ka3 Rps6ka5 Rps6ka1 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d Map2k7 Map2k6 Dusp3 Dusp4 Ubb Ripk2 Ubc Dusp7 Dusp6 Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid Clps Lipf Pnlip Cel Pnliprp2 Pnliprp1 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 97%10228310 Metabolism of lipids Srebf1 Prkag2 Cyp24a1 Csnk2a2 Csnk2a1 Pik3c3 Csnk2b Them4 Pik3r4 Acaca Fasn Mmut Pcca Ran Pccb Prkab2 Ch25h Amacr Hsd17b4 Mmaa Osbpl3 Slco1a4 Pcyt2 Osbpl2 Etnk2 Osbpl7 Cept1 Osbpl6 Baat Etnk1 Etnppl Osbpl9 Chka Hsd3b7 Scp2 Chkb Akr1d1 Selenoi Slc10a1 Phospho1 Acox2 Fabp6 Stard5 Acot8 Alb Osbp Slc27a5 Slc51a Slc27a2 Slc51b Abcb11 Inpp5e Mgll Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Mtm1 Fig4 Vac14 Mtmr12 Mtmr4 Pi4k2a Ndufab1 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Ppara Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 Akr1c18 Akr1c19 Akr1c21 Rxra Akr1c12 Mecr Akr1c13 Ptdss1 Ptdss2 Gpd1l Hacd1 Hacd2 Hacd3 Hacd4 Tbl1x Lpgat1 Far2 Far1 Pip4k2b Pip4k2c Pip4k2a Pitpnb Mcat Acad11 Tgs1 Ugt8 Pik3c2b Liph Lipi Mtmr7 Ppt2 Mtmr6 Crebbp Ppt1 Akr1c3l1 Mtmr9 Sptlc1 Mfsd2a Mfsd2b Slc25a20 Sptlc2 Gpat4 Sptlc3 Gpat3 Ormdl2 Hdac3 Aacs Sptssa Acot9 Degs2 Acot7 Ormdl3 Bdh2 Degs1 Rufy1 Cers6 Tbl1xr1 St8sia5 Cers5 Pnpla5 Cers4 Pnpla6 Morc2 Abcg2 Pnpla3 Cers3 Pnpla4 Cers2 Ppard Fa2h Enpp6 Pnpla2 Cyb5b Abcc1 Tafazzin Ptges3 Agk Sphk2 Sgms1 Akr1c1 Tspo Akr1c9 Gc Spns2 Pip5k1a Sphk1 Sgms2 Ncor2 FABP12 Pcyt1b Kdsr Carm1 Pcyt1a Abhd3 Hsd17b12 Hsd17b13 Akr1c12l1 Fitm2 Fitm1 Tnfaip8l2 Tnfaip8l3 Tnfaip8l1 Pgp Fabp5 Inpp5k Elovl2 Acly Elovl3 Elovl5 Elovl1 Elovl6 Elovl7 Pik3r5 Tecrl Pik3r6 Awat2 Awat1 Pik3cg Acss3 Acp6 Them5 B3galnt1 Acadvl B4galnt1 Gal3st1 Cpt1a Ddhd2 Cpt1b Agpat4 Agpat1 Agpat2 Slc44a3 Slc44a4 Slc44a5 Eci1 Gde1 Cerk Cds1 Hsd17b8 Mid1ip1 Slc22a5 Hsd17b3 Dhrs7b Cpne1 Cpne3 Star Cpne6 Cpne7 Pemt Cidea Cidec Pip4p1 Faah Pitpnm2 Cyp2j16 Pitpnm3 Pitpnm1 Cyp4f39 Stard4 Stard6 Cyp2j3 B3gnt5 Cyp4f1 Decr1 Acot11 Cyp4a14 Scd1 Acot12 Cyp4f3 Acot13 Cyp4f40 Plekha8 Cyp4a12 Plekha6 Cyp4b1 Plekha5 Plekha4 Cyp4f4 Plekha3 Cyp4a10 Plekha2 Cyp2d4 Plekha1 Acsl1 Cyp4a2 Lpcat1 Lhb Scap Glb1l Acsl5 Pi4kb Acsl6 Pi4ka Pik3c2g Ugcg Fads2 Tpte2 Sacm1l B4galt5 Lpcat2 B4galt6 Hmgcll1 Fads1 Cbr4 Glb1l3 Fabp2 Fabp3 Glb1l2 Fabp4 Fabp7 Tecr Acsbg1 St3gal2 Hexa Acsbg2 Fabp9 Hexb Srd5a3 Arsa Srd5a1 St3gal3 Smpd2 Srd5a2 Smpd3 St6galnac5 Cga Smpd4 St6galnac6 Smpd1 Miga2 Gba1 Pla2g15 Gba3 Miga1 Gba2 Gpd2 Enpp7 Gpd1 Neu2 B3galt4 Pld6 Galc Asah2 Fut2 Glb1 Neu3 Fut1 Asah1 Dgat2l6 Neu4 Acaa2 Sts Vdr Gm2a Acbd6 Neu1 Acsf3 Arsl Acsf2 Arsk Dbi Arsj A4galt Arsi Cyp39a1 Cpt2 Cyp19a1 Arsg Hmgcs2 Ncoa2 Pon2 Gla Sumf1 Cyp11a1 Tmem86b Cyp1b1 Arsb Cdipt Sumf2 Alox15b Cyp51a1 Lclat1 Cyp8b1 St3gal5 Cyp7b1 Chpt1 Nr1h4 Pctp Thrsp Cyp21 Stard10 Cyp46a1 Tnfaip8 Cyp27a1 Pik3r1 Cyp11b1 Med1 Fdx1 Pik3r2 Pik3r3 Cyp11b3 Cyp11b2 Fdxr Fdx2 Cyp7a1 Inppl1 Inpp5d Pla2g4b Lpcat3 Lpcat4 Abhd4 Pnpla8 Plaat1 Pla2g3 Plaat5 Mboat1 Mboat2 Pik3cb Pik3cd Pik3ca Slc44a1 Slc44a2 Arf1 Ocrl Acoxl Crot Acox3 Alox12 Gpx4 Hpgd Alox5 Lta4h Alox15 Gstm4 Cyp2c66 Cyp2c11 Cyp2e1 Cyp1a1 Ephx2 Cyp1a2 Phyh Ltc4s Ptgs2 Eci2 Hacl1 Mlycd Cds2 Gnpat Acox1 Ehhadh Acaa1b Hao2 Pecr Pik3c2a Decr2 Nudt19 Acot1 Gpx2 Acot2 Aloxe3 Gpx1 Acot5 Alox12b Acot3 Acot4 Plb1 Agps Hmgcl Acbd4 Mbtps1 Echs1 Abcc3 Acat1 Crat Inpp5j Psap Hsd3b Cyp17a1 Hsd3b6 Serpina6 Hsd3b5 Hsd3b1 Hsd3b5-ps1 Hsd11b1 Hsd11b2 Fabp1 Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Acer3 Plpp2 Sgpp2 Plpp3 Plpp1 Sgpp1 Pip5k1b Lpin3 Lpin2 Arf3 Cbr1 Tbxas1 Hpgds Oxct2a Ptges Bdh1 Ptgds Oxct1 Ptgis Ptges2 Ptpn13 Sin3a Sin3b Osbpl5 Pla1a Osbpl8 Osbpl10 Acsl3 Acsl4 Pip5k1c Hadha Hadhb Mapkapk2 Acadl Hadh Cubn Ctsa Kpnb1 Ldlrap1 Osbpl1a Ptgs1 Smarcd3 Rab5a Rab4a Lbr Synj1 Pld1 M6pr Mtmr14 Pla2g4a Synj2 Mtmr3 Crls1 Cyp3a9 Pon3 Pon1 Slco1b2 Dgat2 Gk Gpam Dgat1 Cyp3a18 Agmo Cyp3a1 Mogat1 Cyp3a62 Gpat2 Tspoap1 Cyp3a2 Mogat2 Mtmr1 Gykl1 Lrp2 Pomc Akr1b1 Acadm Alox5ap Rab14 Agpat3 Pld2 Lgmn Aldh3a2 Abcd1 Abcd3 Acbd5 Stard7 Chat Alpi Cyp2u1 Pias4 Ube2i Acads Cyp27b1 Akr1b10 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Pla2g6 Bmx Ggt1 Dpep1 Plpp6 Sbf1 Dpep2 Fdps Idi1 Pten Hsd17b7 Mvk Fdft1 Sqle Ebp Ggt5 Hmgcs1 Arv1 Ggps1 Sc5d Acat2 Nsdhl Dhcr24 Sumo3 Dhcr7 Lss Srebf2 Tm7sf2 Pmvk Hmgcr Mvd Msmo1 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%10230718 Processing and activation of SUMO Ube2i Sae1 Senp2 Sumo1 Sumo3 Senp1 Senp5 Senp5l1 Uba2 Sumo2 Rwdd2b ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation Copa Dynll1 Dynll2 Gorasp1 Ubxn1 Copb2 Arf1 Copb1 Cope Napa Golgb1 Gosr1 Gosr2 Lman1l Calr Sec24d Sec24c Sec24b Sec24a Psmc1 Pdia3 Spta1 St8sia4 Sptbn1 Sptb Sptbn2 Sptan1 Sptbn5 Sptbn4 St8sia2 Chst10 Mgat5 Mgat2 Mgat1 Mgat3 St6gal1 Manea Man1c1 Lman1 Fut8 Fuca1 Actr1a Man1a2 Lman2 Man1a1 St8sia6 Man2a1 Man2a2 Mgat4c Mgat4a Mgat4b St8sia3 Dctn1 Tfg Dctn2 Dctn4 Trappc2l Kdelr2 Kdelr3 Trappc10 Slc35c1 Slc35a1 Kdelr1 Arf4 Arf3 Tmed10 Rps27a Trappc6b Trappc6a Nagk Gnpnat1 Amdhd2 Sec31b Uap1 Areg Gfpt1 Uba52 Sec31a Gfpt2 Pgm3 Renbp F8 Tbc1d20 Copz2 Copz1 Arf5 Golga2 Uso1 Actr10 Stx5 Ykt6 Ubb Ubc Arcn1 Amfr Engase Arfgap3 Ngly1 Arfgap2 Rad23b Arfgap1 Ctsa Gria1 Rab1b Dync1li2 Dync1li1 St8sia5 Bet1l Cnih1 Cnih3 Cnih2 Col7a1 Trappc9 Ppp6c Sar1b Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Csnk1d Serpina1 Rab1A Mcfd2 Folr1 Bet1 Ins1 Scfd1 Ins2 Cog1 Cog2 Cog3 Cog4 Preb Cog5 Cog6 Cog7 Cog8 B4galt4 B4galt5 B4galt6 Ank1 St3gal6 St3gal4 St3gal2 Srd5a3 St3gal3 Tmem115 St6galnac5 St6galnac6 St3gal1 B4galt2 B4galt3 Neu2 Sec23ip Glb1 Neu3 Sec16b Neu4 Sec16a Neu1 Ctsc Ppp6r3 St3gal5 Mia2 Mia3 Dync1h1 Dpm1 Dpm2 Dpm3 Tmed9 Ctsz Cmas Alg9 Alg8 Tgfa Alg6 Alg5 Alg3 Dync1i2 Canx Alg2 Alg1 Gmds Gne Nus1 Dync1i1 Pmm2 Pmm1 Nudt14 Stx17 Umod Npl Dhrsx Asgr2 Asgr1 Slc17a5 Nanp Nans St8sia1 Mpi Sec13 St6galnac3 Dhdds Dolpp1 Fuom Gbf1 St6gal2 Tmed2 Dolk Tmed3 Alg13 Copg1 Alg14 Alg12 Copg2 Mpdu1 Fpgt Gmppa B4galnt2 Tmed7 Fcsk St6galnac1 St6galnac2 Dpagt1 Ankrd28 Gfus Cd59 Cd55 Sec22a Nsf Napb Napg Sec23a Vcp Lman2l Mvd RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 97%10228602 RNA Polymerase III Transcription Initiation From Type 3 Promoter Polr3e Tbp Snapc4 Polr3b Snapc1 Polr3c Snapc2 Polr3f Polr3g Polr3gl Crcp Bdp1 Polr2h Polr2e Polr2f Polr1c Pou2f1 Polr3a Brf2 Polr3d Snapc3 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229608 Thyroxine biosynthesis Txndc11 Duoxa1 Duoxa2 Slc5a5 Iyd Tshb Cga Dio1 Dio2 Duox1 Dio3 Cav1 Duox2 Tpo CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE Psenen Psen1 Ywhae Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Ngf Itsn1 Rac1 Vav3 Vav2 Vav1 Ngfr Ngef Bex3 Itgb3bp Casp2 Mcf2l Tiam2 Bcl2l11 Arhgef15 Arhgef17 Mapk8 Arhgef16 Traf6 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Rps27a Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Sqstm1 Fgd1 Fgd4 Arhgef37 Uba52 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Ubb Ubc Sos2 Sos1 Tiam1 Casp3 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%10230752 DEx H-box helicases activate type I IFN and inflammatory cytokines production Dhx9 Irf7 Dhx36 Myd88 Rela Nfkb2 Nfkb1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-RNO-74160.1 Gene expression (Transcription) Ajuba Cited2 Ywhae Eloc Elob Atxn3 Foxg1 Foxo6 Foxo4 Foxo1 Ppm1a Tgif1 Tgif2 Sp1 Tfdp2 Tfdp1 Ccnk Atp1b4 Ccnc Trim33 Rnf111 Smad2 Smad3 Wwtr1 Usp9x Ccnt2 Rbl1 E2f4 E2f5 Skil Kat2a Maml3 Rbpj Hdac5 Hdac4 Maml1 Maml2 Hdac11 Hdac10 Notch3 Hdac9 Hdac8 Sgk1 Ppara Cdk5r1 Nek4 Prr5 Tfap2c Ddx21 Tfap2b Rictor Snrpf Snrpg Snrpb Prmt5 Mapkap1 Snrpd3 Tasor Morc2 Setdb1 Atf7ip Pphln1 Snrpepl2 Tp53 Lamtor5 Rptor Lamtor3 Rraga Lamtor4 RragB Lamtor1 Rragc Lamtor2 Rragd Mtor Rheb Mlst8 Slc38a9 Bax Ywhaq Ywhah Ywhab Sfn Lhb Prmt6 Dnmt3a Actl6b Aurka Rb1 Tgfb1 Cga Med23 Med24 Med20 Tasp1 Akap8l Phf20 Cxxc1 Kat8 Med27 Med12 Med1 Yeats2 Med13 Med14 Wdr82 Med10 Med4 Pparg Med6 Kat14 Mbip Prdx1 Hcfc1 Med16 Med17 Hcfc2 Dr1 Kansl3 Kansl1 Kansl2 Phf20l1 Setd1b Bod1l1 Setd1a Pagr1 Tada3 Med30 Tada2a Med31 Ppargc1a Ppargc1b Kmt2d Mcrs1 Zzz3 Kmt2b Sgf29 Psip1 Ogt Sesn2 Sesn1 Cdc25c Tfap2a Npm1 Skic8 Ssrp1 Ctr9 Paf1 Ttf1 Gpx2 Wwox Tead3 Tead2 Tbx5 Tead4 Cnot3 Cnot2 Plk3 Nr4a1 Btg2 Cnot1 Cnot7 Plk2 Cnot6 Cnot11 Tnks1bp1 Cnot4 Cnot9 Cnot8 Cnot6l Cnot10 Cpap Mapkapk5 Ccnb1 Cdk1 Elf1 Cbfb Tfb2m Tfam Runx1 Polrmt Itch Mapk1 Rps27a Mapk3 Sirt3 Lmo2 Lmo3 Serpinb13 Zfpm1 Gata1 Ppp2cb Gata2 Ppp2ca Uba52 Ring1 Tp73 Ccnd2 Phc2 Cbx6 Ccnd3 Phc1 Cbx4 Cbx2 Phc3 Cdk6 Tcf3 Sin3a Sin3b Bmi1 Yaf2 Pax5 Elf2 Tal1 Yap1 Rnf2 Pcgf5 Tcf12 Pml Map2k6 Ctsk Tdg Ubb Ctsl Ubc Exo1 Rfc5 Rfc3 Mapk14 Rfc4 Pcna Rfc2 Ppp2r1b Ppp2r1a Lsm10 Nelfa Lsm11 Nelfb Zfp473 Nelfe Mapk11 Ctdp1 Ncbp2 Ncbp1 Supt4h1 Nelfcd Lbr Rpa1 Rpa2 Rpa3 Cdk2 Usp7 Tcea1 Ercc6 Cdk5 Chd4 Actg1 Paxip1 Mre11 Ube2i Kat5 Nbn Hus1 Atrip Dna2 Blm Baz1b Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Abl1 Rad17 Atm Atr Ccna1 Ccna2 Phf6 Rmi2 Parp1 Rmi1 Brip1 H2ab2 Smarca5 Prkaa1 Sumo1 H2ac4 Rhno1 Wrn Prkag3 Psmb6l1 Rad50 Prkag1 Prkag2 Ccnd1 Kmt2a Kmt2c H2ac18 Topbp1 Taf1d Rbbp8 Rrn3 Ezh2 Taf1a Psma4 Taf1c Psma3 Brca1 Taf1b Psma6 Mta1 Mta2 Psma5 Mta3 Psma2 Mbd3 Psma1 Polr1b Rad1 Polr1c Bnip3l Steap3 Polr1a Csnk2a2 Polr1f LOC134478826 Polr1g Csnk2a1 Polr1e Ywhag Polr1h Psmd12 Psmd11 Chd3 Ubtf Suz12 Gatad2a Hist1h2bq Gatad2b Ctnnb1 Psmd14 Psmd13 Wdr5 Ash2l Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Gsk3b H2aj Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Ski Psmd7 Smad4 Psmd6 Ube2d3 H2az2 Psmd8 Psmd2 Ube2d1 H2bc6 Rbbp5 Smurf2 Rbbp4 Smurf1 H2bc4 Hist1h4m H2bc1 Ran Rbbp7 Smad7 Psmd1 Suv39h1 Adrm1 Smyd2 Prkab2 Hist1h2ai Prkab1 Aebp2 Prdm9 Ehmt1 Cdc73 Pcgf2 Cox7a2l Cox6a1 Cox6a2 Mphosph8 Hdac2 Hdac1 Kmt5a Higd1c Coxfa4 Cox6c2 Sirt1 Cycsl2 Cox6b1 Cox8a Cox6b2 Cox8c Brpf3 Cox7b Cox4i1 Cox4i2 Mt-co3 Cox7c Mt-co2 Cycs Rnf34 Cox7a1 Cox7a2 Cox5a Cox5b Mt-co1 Cbx5 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Nr1h3 Taf9b Nr1h2 Polr2j Gpi Taf15 Rxrb Taf11 Rxra Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Pgr Gtf2f2 Gata3 Gtf2f1 Rxrg Gtf2h3 Gtf2h5 Tbp Tbl1x Ercc2 Ccnh Ercc3 Taf4b Pip4k2b Taf7l-ps1 Pip4k2c Gtf2a1 Pip4k2a Cdk7 Gtf2a2 Cited1 Gtf2b Taf8 Taf7 Taf6 Esr1 Taf5 Esr2 Taf4 Gtf2e1 Cdk9 Taf2 Crebbp Taf1 Gtf2e2 Hdac3 Pou2f1 Pdpk1 Prmt1 Tbl1xr1 Rara Foxo3 Ppard Ncor2 Ep300 Gps2 Src Ncoa3 Kat2b Rarg Cdkn1b Nr5a2 Foxp3 Sympk Clp1 Pip4p1 Pcf11 Cstf1 Nudt21 Cstf2 Cstf3 Slbp Sf3b1 Vdr Men1 Arnt Ncoa2 Srrt Nr1h4 Arnt2 Fip1l1 Papola Cpsf4 Cpsf6 Cpsf7 Cpsf1 Cpsf2 Cpsf3 Furin Polr3a Brf2 Polr3d Snapc3 Polr3e Snapc4 Polr3b Snapc1 Polr3c Snapc2 Polr3f Polr3g Polr3gl Crcp Bdp1 Rrp8 Ramac Myc Zfp839 Ddit4 Cited4 Zfp819 Cstf2t Phax Ell2 Smarca4 Ell3 Cdk13 Cdk12 Ell Pabpn1 Ywhaz Ing5 Ing2 Zik1 Ptpn11 Brd1 Zfp867 Zfp866 Ago4 Mtf2 Prkra Mecp2 Ago3 Zfp612 Ago2 Zim1 Ago1 Zfp617 Dicer1 Brf1 Tarbp2 Gls Zfp605 Atad2 Eloa Zfp46 Zfp804b Ipo8 Rnmt Rprd1a Rprd1b Supt6h Zfp418l1 Sesn3 Tfap2e Gtf3a Brpf1 Npas4 Tp53rkb Tp53rka Zfp52 Kat6a Znf354c Znf354b Mybbp1a Znf354a Zfp90 Zfp78 Zfp74 Tsn Maged1 LOC102546572 Zfp81 Mllt3 Mllt1 Ints4 Ints5 Ints6 Zfp398 Ints7 Ints8 Ints9 Ints1 Myo1c Ints2 Ints3 Zfp386 Zfp764l1 Rffl Zfp133 Txn Znf382 Cradd Pidd1 Znf394 Tpx2 Tmem219 Tp63 Gsr Banp Nabp1 Nabp2 Esrra Esrrb Zfp273l-ps1 Esrrg Ezhip Zfp180 Zfp189 Zfp184 Ccng1 Tsnax Zfp169 LOC102547287 Nr5a1 Zfp94l1 LOC108348267 Zfp455l1 Zfp790 Zfp317 Zfp799 Zfp300 Zfp786 Zfp788 Rsl1 Nr3c2 Nr3c1 Zfp770 Znf773 Zfp775 Yeats4 Cbx3 Zfp764 Zfp763 Jmy Zfp111 Zfp113 Zfp597 Znf750 Zfp599 Nr1d2 Nr1d1 Zfp583 Zfp101 Gtf3c2 Ar Gtf3c1 Gtf3c4 Dyrk2 Gtf3c3 Gtf3c6 Gtf3c5 Trim28 Iws1 Thrb Thra Dek Znf740 Zfp566 Zfp324 LOC120095871 Nr1i3 Nr1i2 Zfp954 Zfp951 Zfp790l2 Zfp710 Zfp952 Znf18 Zfp719 Prdx2 Prdx5 Zfp704 Zfp945 Zfp703 Zfp706 Zfp948 ENSRNOG00000070049 Krabd3 L3mbtl2 L3mbtl1 Akt3 Daxx Ezh1 Akt2 Nrbf2 Nrbf2l1 Zfp758 Akt1 Zscan25 Zscan22 Pou2f2 Zfp746 Pcgf6 Noc2l Txnrd1 Mbd2 Tcf7 Tigar Tcf7l1 Zfp964 Hipk1 Zfp286a Rabggta Rabggtb Ppp1r13l Ppp1r13b Zfp119bl Max Jarid2 Rorc Gls2 Rorb Stk11 Ints13 Ints14 Dnmt1 Ints11 Ints12 Leo1 Ints10 Zc3h8 Rprd2 G6pdx Mga Zfp37-ps1 Rngtt E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 LOC120101823 Nr6a1 Zfp496 Zfp808l3 Eaf1 Eaf2 Zfp483 Rpap2 Zfp248 Nuak1 Chm Usp2 Hnf4a Hnf4g Zkscan8 Tcf7l2 Zkscan7 Zkscan1 Zkscan4 Zkscan5 Zkscan3 Nr4a3 Nr4a2 Zfp955a Zfp955b Bmal1 Lef1 Nrif1 Runx3 Zfp12 Zfp13 Zfp950l16 Zfp282 Ttc5 Eloa2l Ccne1 Nr2c2 Ccne2 Nr2c1 Ice2 Kctd1 Pou4f1 Znf431l2 Pou4f2 Zfp668 Znf689 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Ssu72 Znf624l Zfp641 Phf19 Zfp647 Znf667 Znf426 Aff4 Meaf6 Nr2f6 Nr0b2 Nr0b1 Mdm4 Nr2f1 Zfp385a Nr2e3 Gadd45a Zfp212 Epop Igfbp3 Zfp213 Zfp455 Tnrc6c Rex2l4 Tnrc6a Tnrc6b Zfp445 Zfp688 Zfp950l5 Pbrm1 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Brd7 Arid1a Arid1b Actl6a Smarce1 Smarcc1 Smarca2 Casp2 Cavin1 Kdm5b Aurkb Tsc2 Tsc1 HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis Abcg2 Fech Uros Ppox Cox10 Alad Alas1 Alas2 Cox15 Hmbs Cpox Urod Alb DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate Chia Chit1 Si Amy2 Lct SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230818 SUMOylation of SUMOylation proteins Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Pias4 Ube2i Sumo1 Sumo3 Nup93 Nup50 Nup35 Nup54 Nup98 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-RNO-159424.1 Conjugation of carboxylic acids Glyat Glyatl3 Acsm2 Acsm4 Acsm5 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-RNO-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Bcl2l1 Traf6 Aamp Ikbkg Cyld Map3k7 P2rx7 Tab3 Ube2n Tab2 Mapk12 Tab1 Mapk13 Pycard Txnip Mapk11 Birc2 Sugt1 Nlrp3 Casp9 Mefv Nlrp1a Pstpip1 Nod2 Nod1 Panx1 Map2k6 Txn Ripk2 Casp2 Hsp90ab1 Casp8 Itch Mapk14 Aim2 Casp1 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229662 HDL assembly Abca1 Bmp1 Prkaca A2m Zdhhc8 Prkacb Apoa1 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism Pdha1 Rps27a Pdha2 Pklr Uba52 Pkml1 Ldhal6b Glo1 Wdr26 Hagh Nek1 Mkln1 Pdhx Fahd1 Ranbp9 Gid4 Gstz1 Maea Ldha Ldhb Ldhc Me1 Armc8 Me3 Me2 Pdk4 Dld Rmnd5b Pdk3 Pdk2 Pdk1 Gpt Ubb Ubc Pdhb Pgam5 Dlat Pdp1 Pdpr Pdp2 Vdac1 Pc REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231584 Regulation of HMOX1 expression and activity Hmox1 Hm13 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-RNO-202131.1 Metabolism of nitric oxide: NOS3 activation and regulation Zdhhc21 Dnm2 Cyb5b Hsp90aa1 Lypla1 Ddah1 Nostrin Cygb Nos3 Akt1 Spr Calm3 Cav1 Nosip ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels P2rx1 Trpc3 Itpr3 Itpr2 P2rx7 P2rx6 Itpr1 P2rx5 P2rx4 Trpc7 P2rx3 P2rx2 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228378 Nucleotide biosynthesis Dhodh Adsl Impdh2 Cad Impdh1 Gmps Adss2 Adss1 Pfas Atic Umps Ppat Gart Paics HDACS DEACETYLATE HISTONES%REACTOME%R-RNO-3214815.1 HDACs deacetylate histones Arid4b Rcor1 Arid4a Tbl1x H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Chd4 Hdac2 H2ac18 Hdac1 Hist1h2ai Mta1 Mta2 Kdm1a Mta3 Mbd3 Hdac10 Hdac3 Hdac8 Chd3 Hist1h2bq Gatad2a Tbl1xr1 Gatad2b Ncor2 Gps2 Sap18 Hist3h2ba Hmg20b H2ac4 H2bc18 Sap30l H2ac25 Suds3 Brms1 Rest NETRIN-1 SIGNALING%REACTOME%R-RNO-373752.1 Netrin-1 signaling Cdc42 Unc5a Prkcq Dscaml1 Dscam Ptk2 Ezr Src Fyn Dcc Ntn4 Rac1 Trio Nck1 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%10229454 Role of phospholipids in phagocytosis ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Plcg1 Plpp4 Iglc1 Plpp5 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Pld4 Syk ENSRNOG00000065564 Pld3 ENSRNOG00000066971 Fcgr2 ENSRNOG00000063341 Pld1 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Pik3r1 ENSRNOG00000063148 Pik3r2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Cd3g ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Prkce Fcgr1a ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Prkcd Pla2g6 Pld2 Pik3cb Pik3ca NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%10230764 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Ube2i Tfap2e Tfap2c Tfap2a Sumo1 Wwox Tfap2b Kctd1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231570 RHOF GTPase cycle AABR07021573.2 Rhof Syde1 Lmnb1 Myo9b Vamp3 Steap3 Depdc1b Cav1 Mtmr1 Fam169a Actn1 Farp1 Baiap2l2 Diaph3 Basp1 Arhgap5 Actg1 Arhgap1 Arhgap21 Mcam Add3 Akap12 Rab7a Tor1aip1 Arhgap32 Pik3r1 Arhgap12 Esyt1 Pik3r2 Baiap2l1 Diaph1 Srgap2 Slc4a7 Sowahc Snap23 Senp1 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates Rad51b Rad50 Bard1 Top3a Palb2 Firrm Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc3 Slx1b Xrcc2 Atm Mus81 Rmi2 Fignl1 Rmi1 Brip1 Mre11 Eme2 Kat5 Eme1 Exo1 Nbn Gen1 Slx4 Dna2 Wrn Rad51c Blm Spidr Rad51 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 97%10228724 Glucagon signaling in metabolic regulation Prkar1a Prkar2a Prkar1b Gcg Prkaca Prkacb Gcgr HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC Pla2g4c Pla2g4a Pla2g4e Pla2g4d Plbd1 Pla2g4b Pla2g4f Pla2g15 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-RNO-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins Zfp719 Zfp950l5 H2bc6 H2bc4 Hist1h4m H2bc1 ENSRNOG00000070049 H2ac18 Hist1h2ai Zfp317 Zfp758 Zfp52 Zfp964 Hist1h2bq Znf354a Znf431l2 Setdb1 LOC102546572 Atf7ip ENSRNOG00000065205 Cbx5 Znf624l H2aj Trim28 H2ab2 H3-3b Hist3h2ba Znf382 H2ac4 Zfp324 LOC120095871 H2bc18 Rex2l4 Zfp808l3 Zfp867 H2az2 PI3K AKT ACTIVATION%REACTOME%R-RNO-198203.1 PI3K AKT activation Irs2 Pik3cb Ntrk1 Ngf Pik3ca Pik3r1 Irs1 Pik3r2 Rhoa FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-RNO-173599.1 Formation of the active cofactor, UDP-glucuronate Slc35d1 Uxs1 Ugp2 Ugdh G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events Adcy8 Adcy5 Adcy6 Mapk1 Adcy9 Prkaca Prkacb Prkcg Prkcd Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Grk2 Gnal Gnaq Gnat3 Prkar2a Pde1b Pde1c Pde1a Plcb4 Plcb3 Pla2g4a Plcb2 Plcb1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-RNO-69895.1 Transcriptional activation of cell cycle inhibitor p21 Zfp385a Tp53 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%10230392 ATP sensitive Potassium channels Kcnj11 Kcnj8 Abcc9 Abcc8 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-RNO-9619229.1 Activation of RAC1 downstream of NMDARs Camk1 Calm3 Camkk1 Camkk2 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%10229478 Signalling to ERK5 Mapk7 ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins Defal1 Defa8 LOC102554637 Defa6 Defa3 Defa31 Defa Try10 Prss2 Prss2l1 Prss3 Prss1 Art1 Np4 Defa24 Cd4 Try5 Defa9 FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization Catsper4 Catsperb Acr Catsper2 Izumo4 Hvcn1 Izumo3 Catsper3 Izumo2 Catsper1 Izumo1 Kcnu1 Cd9 Hyal5 Catsperg Catsperd PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%10228776 PI3K AKT Signaling Cd28 Nedd4 Cd86 Cd80 Ezh2 Psma4 Psma3 Psma6 Mta1 Mta2 Psma5 Mta3 Psma2 Mbd3 Psma1 Csnk2a2 Kl Csnk2a1 Gab1 Fgf10 Flt3 Trib3 Fgf3 Psmd12 Fgf22 Psmd11 Chd3 Suz12 Fgf7 Gatad2a Gatad2b Psmd14 Ppp2r5b Psmd13 Trat1 Ppp2r5a Foxo6 Psmb5 Foxo4 Psmb4 Foxo1 Csnk2b Psmb7 Them4 Psmb6 Mkrn1 Psmb1 Ppp2r5e Eed Insr Psmb3 Psmb2 Psma7 Fgfr3 Psmc5 Egf Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Rbbp4 Rbbp7 Psmd1 Hgf Adrm1 Met Mecom Rps6kb2 Nr4a1 Grb2 Fyn Pdgfa Trim27 Pdgfb Otud3 Usp13 Frk Hdac2 Akt3 Hdac1 Akt2 Cd19 Akt1 Tnks2 Rnf146 Tnks Erbb2 Pip5k1b Erbb3 Nrg2 Nrg1 Nrg3 Traf6 Mapk1 Hbegf Rps27a Mapk3 Sgk1 Rac2 Ppp2cb Areg Ppp2ca Uba52 Ring1 Frs2 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Bmi1 Rnf2 Ppp2r5d Pml Ubb Prr5 Ubc Rictor Pip5k1c Irak1 Pip4k2b Ppp2r1b Pip4k2c Ppp2r1a Pip4k2a Strn Egfr Esr1 Esr2 Chuk Mapkap1 Rhog Pdpk1 Rac1 Foxo3 Ntf3 Ntf4 Lamtor5 Rptor Kit Ntrk2 Pip5k1a Akt1s1 Bdnf Lamtor3 Rraga Lamtor4 RragB Lamtor1 Src Rragc Lamtor2 Rragd Kitlg Mtor Rheb Cdkn1b Mlst8 Slc38a9 Lck Pik3r5 Pik3r6 Pik3cg Icos Ier3 Phlpp1 Maf1 Sall4 Pdgfrb Pdgfra Ntrk3 Prex2 Usp7 Fgf16 Wwp2 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Ins1 Fgf6 Fgf5 Fgf8 Ins2 Fgf9 Klb Fgf19 Fgfr4 Ereg Fgfr1 Btc Chd4 Il1rap Gab2 Vav1 Pik3r1 Pik3r2 Pik3r3 Il33 Tgfa Pik3ap1 Irs1 Irs2 Casp9 Xiap Stub1 Irak4 Pik3cb Pik3cd Pik3ca Myd88 Pten Tsc2 Il1rl1 Ptpn11 Psmb6l1 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%10229102 NOD1 2 Signaling Pathway Traf6 Aamp Ikbkg Cyld Nod2 Map3k7 Nod1 Tab3 Ube2n Tab2 Mapk12 Tab1 Mapk13 Map2k6 Mapk11 Birc2 Casp2 Ripk2 Casp9 Casp8 Mapk14 Itch Casp1 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels Kcnj15 Kcnj16 Kcnj3 Kcnj2 Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gabbr1 Gnb4 Gnb3 Gnb5 Gng11 Gabbr2 Gng12 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gng10-ps1 Kcnj10 Kcnj12 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%10230822 Depolymerization of the Nuclear Lamina Lpin3 Lpin2 Prkcb Cdk1 Cnep1r1 Ctdnep1 Lmna Emd Lmnb1 Ccnb1 Prkca ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-6807062.1 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Srebf1 Nsdhl Dhcr24 Srebf2 Tm7sf2 Hsd17b7 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%10230326 Activation of STAT3 by cadherin engagement Rnf19b Cdh11 Cbll1 Jak2 Rps27a Stat3 Arhgef4 Nfkb1 Jup Birc2 Uba52 Ctnnd1 Xiap Cdh1 Ctnna1 Rela Rac1 Ctnnb1 Vcl Il6 Hace1 Cdc42 Il6r Tyk2 Vav2 Ctsb Src Il6st Ctsl Ubb Ctss Ubc Tiam1 Farp2 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10231706 Complex III assembly Uqcrb Fxn LOC120097699 Mt-cyb Uqcrh Uqcrfs1 Uqcr10 Nfs1 Ttc19 Iscu Uqcrq Lyrm7 Cyc1 Hscb Hspa9 Uqcrc2 Uqcrc1 Lyrm4 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-RNO-73943.1 Reversal of alkylation damage by DNA dioxygenases Alkbh5 Fto FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190374.1 FGFR1c and Klotho ligand binding and activation Fgf23 Kl Fgfr1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 97%10231520 EGR2 and SOX10-mediated initiation of Schwann cell myelination Adgrg6 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism Scp2 Acot8 Acox1 Acsl1 Acaa1b Elovl2 Elovl3 Elovl5 Elovl1 Fads2 Abcd1 Hsd17b4 Fads1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus Pip4p1 Pip4k2b Pip4k2c Pip4k2a GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-RNO-212436.1 Generic Transcription Pathway Rad50 Prkag1 Prkag2 Ccnd1 Kmt2a Kmt2c H2ac18 Topbp1 Rbbp8 Ezh2 Psma4 Psma3 Brca1 Psma6 Cited2 Mta2 Psma5 Ywhae Psma2 Mbd3 Psma1 Rad1 Eloc Bnip3l Csnk2a2 Elob Steap3 LOC134478826 Csnk2a1 Ywhag Psmd12 Psmd11 Chd3 Suz12 Gatad2a Hist1h2bq Gatad2b Ctnnb1 Psmd14 Psmd13 Wdr5 Ash2l Atxn3 Foxg1 Psmb5 Foxo6 Psmb4 Foxo4 Csnk2b Foxo1 Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 H2aj Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Ppm1a Tgif1 Tgif2 H2bc18 Ski Sp1 Tfdp2 Psmd7 Tfdp1 Smad4 Psmd6 Ccnk Ube2d3 H2az2 Atp1b4 Psmd8 Ccnc Psmd2 Ube2d1 Trim33 Rnf111 H2bc6 Rbbp5 Smurf2 Smad2 Rbbp4 Smurf1 Smad3 H2bc4 Wwtr1 Usp9x Hist1h4m Ccnt2 H2bc1 Rbbp7 Rbl1 E2f4 Smad7 Psmd1 E2f5 Skil Adrm1 Kat2a Smyd2 Prkab2 Maml3 Hist1h2ai Rbpj Prkab1 Hdac5 Hdac4 Maml1 Maml2 Hdac11 Hdac10 Notch3 Hdac9 Hdac8 Prdm9 Ehmt1 Pcgf2 Cox7a2l Cox6a1 Cox6a2 Hdac2 Hdac1 Kmt5a Higd1c Coxfa4 Cox6c2 Sirt1 Cycsl2 Cox6b1 Cox8a Cox6b2 Cox8c Brpf3 Cox7b Cox4i1 Cox4i2 Mt-co3 Cox7c Mt-co2 Cycs Rnf34 Cox7a1 Cox7a2 Sgk1 Cox5a Cox5b Mt-co1 Ppara Cdk5r1 Nek4 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Prr5 Nr1h3 Tfap2c Polr2i Nr1h2 Taf9b Polr2j Gpi Tfap2b Taf15 Rictor Rxrb Taf11 Rxra Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Pgr Gtf2f2 Gata3 Gtf2f1 Rxrg Gtf2h3 Gtf2h5 Tbp Tbl1x Ercc2 Ccnh Ercc3 Taf4b Pip4k2b Taf7l-ps1 Pip4k2c Pip4k2a Cdk7 Prmt5 Cited1 Taf8 Taf7 Taf6 Esr1 Taf5 Esr2 Taf4 Cdk9 Taf2 Mapkap1 Crebbp Taf1 Hdac3 Pdpk1 Prmt1 Tbl1xr1 Rara Foxo3 Ppard Tp53 Lamtor5 Rptor Ncor2 Lamtor3 Rraga Lamtor4 Ep300 RragB Src Lamtor1 Rragc Lamtor2 Kat2b Rragd Rarg Mtor Rheb Cdkn1b Mlst8 Slc38a9 Nr5a2 Foxp3 Bax Pip4p1 Ywhaq Ywhah Ywhab Sfn Lhb Prmt6 Actl6b Aurka Tgfb1 Cga Vdr Men1 Arnt Nr1h4 Phf20 Arnt2 Med1 Pparg Prdx1 Setd1b Setd1a Kmt2d Kmt2b Furin Sesn2 Sesn1 Myc Zfp839 Ddit4 Cited4 Zfp819 Smarca4 Cdk13 Cdk12 Ell Ywhaz Ing5 Ing2 Zik1 Ptpn11 Brd1 Zfp867 Zfp866 Mecp2 Zfp612 Cdc25c Zim1 Zfp617 Tfap2a Npm1 Gls Zfp605 Atad2 Eloa Zfp46 Zfp804b Zfp418l1 Sesn3 Tfap2e Brpf1 Npas4 Tp53rkb Tp53rka Zfp52 Kat6a Znf354c Znf354b Znf354a Zfp90 Zfp78 Zfp74 Maged1 LOC102546572 Zfp81 Ssrp1 Zfp398 Zfp386 Zfp764l1 Rffl Zfp133 Txn Znf382 Cradd Pidd1 Znf394 Tpx2 Tmem219 Tp63 Gsr Banp Esrra Esrrb Zfp273l-ps1 Esrrg Gpx2 Zfp180 Zfp189 Zfp184 Ccng1 Zfp169 LOC102547287 Nr5a1 Zfp94l1 LOC108348267 Zfp455l1 Zfp790 Zfp317 Zfp799 Zfp300 Zfp786 Zfp788 Rsl1 Nr3c2 Wwox Nr3c1 Zfp770 Znf773 Zfp775 Tead3 Yeats4 Tead2 Cbx3 Tbx5 Zfp764 Tead4 Cnot3 Zfp763 Cnot2 Jmy Plk3 Nr4a1 Zfp111 Btg2 Zfp113 Cnot1 Zfp597 Cnot7 Znf750 Plk2 Zfp599 Cnot6 Nr1d2 Cnot11 Nr1d1 Tnks1bp1 Zfp583 Cnot4 Zfp101 Cnot9 Ar Cnot8 Cnot6l Cnot10 Dyrk2 Cpap Trim28 Thrb Thra Dek Znf740 Zfp566 Zfp324 LOC120095871 Nr1i3 Nr1i2 Zfp954 Zfp951 Zfp790l2 Zfp710 Zfp952 Znf18 Zfp719 Prdx2 Prdx5 Mapkapk5 Zfp704 Zfp945 Zfp703 Zfp706 Zfp948 ENSRNOG00000070049 Krabd3 L3mbtl2 L3mbtl1 Akt3 Daxx Akt2 Nrbf2 Nrbf2l1 Zfp758 Akt1 Zscan25 Zscan22 Zfp746 Pcgf6 Noc2l Txnrd1 Tcf7 Tigar Tcf7l1 Zfp964 Hipk1 Zfp286a Rabggta Rabggtb Ppp1r13l Ppp1r13b Zfp119bl Max Rorc Rorb Gls2 Stk11 G6pdx Ccnb1 Mga Zfp37-ps1 E2f6 E2f7 E2f8 Zfp275 Cdk1 Epc1 Zfp1 Elf1 Cbfb Zfp266 Zfp263 Runx1 LOC120101823 Nr6a1 Itch Zfp496 Zfp808l3 Zfp483 Zfp248 Nuak1 Chm Usp2 Hnf4a Mapk1 Hnf4g Zkscan8 Tcf7l2 Zkscan7 Rps27a Zkscan1 Zkscan4 Zkscan5 Mapk3 Sirt3 Zkscan3 Nr4a3 Nr4a2 Zfp955a Zfp955b Bmal1 Lmo2 Nrif1 Lmo3 Lef1 Serpinb13 Runx3 Zfpm1 Zfp12 Gata1 Ppp2cb Zfp13 Gata2 Ppp2ca Zfp950l16 Uba52 Zfp282 Ring1 Tp73 Ttc5 Eloa2l Ccnd2 Phc2 Nr2c2 Ccne1 Nr2c1 Ccne2 Cbx6 Ccnd3 Phc1 Kctd1 Pou4f1 Cbx4 Znf431l2 Cbx2 Phc3 Pou4f2 Cdk6 Zfp668 Znf689 Tcf3 Sin3a Zfp664 Sin3b ENSRNOG00000065205 Bmi1 Zfp658 Yaf2 Zfp655 Pax5 Znf624l Elf2 Tal1 Zfp641 Yap1 Zfp647 Rnf2 Pcgf5 Znf667 Tcf12 Znf426 Pml Map2k6 Meaf6 Nr2f6 Nr0b2 Ctsk Nr0b1 Mdm4 Ctsl Ubb Nr2f1 Zfp385a Nr2e3 Ubc Gadd45a Exo1 Zfp212 Igfbp3 Rfc5 Zfp213 Zfp455 Rfc3 Mapk14 Rex2l4 Rfc4 Pcna Zfp445 Rfc2 Zfp688 Zfp950l5 Ppp2r1b Ppp2r1a Pbrm1 Nelfa Smarcd1 Nelfb Smarcb1 Zfp473 Nelfe Smarcd3 Mapk11 Ctdp1 Smarcd2 Supt4h1 Nelfcd Brd7 Arid1a Arid1b Lbr Actl6a Rpa1 Rpa2 Smarce1 Smarcc1 Smarca2 Rpa3 Cdk2 Casp2 Usp7 Tcea1 Cdk5 Chd4 Mre11 Ube2i Kat5 Nbn Hus1 Atrip Dna2 Blm Kdm5b Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Abl1 Rad17 Atm Atr Ccna1 Ccna2 Aurkb Rmi2 Parp1 Rmi1 Brip1 Tsc2 H2ab2 Tsc1 Prkaa1 Sumo1 H2ac4 Rhno1 Wrn Prkag3 Psmb6l1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle Gad1 Gad2 Apba1 Gls Syt1 Slc6a11 Slc6a12 Naaa Rims1 Stx1a Slc18a3 Slc22a2 Snap25 Slc22a1 Cask Slc1a1 Slc1a3 Chat Slc1a2 Lin7a Slc38a2 Slc1a7 Lin7b Slc1a6 Lin7c Gls2 Vamp2 Dnajc5 Cplx1 Rab3a Arl6ip5 Hspa8 Aldh5a1 Stxbp1 Slc18a2 Slc6a13 Abat Unc13b Slc5a7 Tspoap1 Slc6a1 Maoa Syn3 Syn2 Syn1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Slc17a7 Slc32a1 CELL CYCLE%REACTOME DATABASE ID RELEASE 97%10228144 Cell Cycle Cenpl Rad50 Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ccnd1 Ndc80 Babam1 Cdk4 Gorasp1 Babam2 H2ac18 Topbp1 Rbbp8 Psma4 Psma3 Ajuba Brca1 Psma6 Psma5 Uimc1 Ywhae Psma2 Psma1 Rad1 Csnk2a2 Csnk2a1 Ywhag Chmp3 Psmd12 Psmd11 Hist1h2bq Chmp7 Psmd14 Psmd13 Ppp2r5b Ppp2r5a Chmp6 Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Ppp2r5e Kif20a Psmb3 Psmb2 Gsk3b H2aj Psma7 Psmc5 Hist3h2ba Psmc2 Tubal3 Psmc1 Rcc1 Psmc4 Spast Psmc3 Espl1 Ppp2r2a Tuba4a Tuba3b Ptk6 Tubb4b Tubb4a Nek2l1 Tuba1a Tfdp2 Psmd7 Tuba1c Tfdp1 Psmd6 Cc2d1b Tubb2b H2az2 Psmd8 Tubb2a Psmd2 Ist1 Ube2d1 H2bc6 Sirt2 Tuba8 Tubb6 Rbbp4 Tubb3 H2bc4 Tubb1 Hist1h4m H2bc1 Ran Rbbp7 Rbl1 E2f4 Psmd1 E2f5 Adrm1 Hist1h2ai Hdac8 Ofd1 Fbxl7 Hdac1 Rps27 Kmt5a Csnk1e Hsp90aa1 Mnat1 Hsp90ab1 Nup93 Nup50 Nup35 Nup54 Nup98 Ccnh Nup58 Nup37 Nup205 Pom121 Cdk7 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Xpo1 Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Tp53 Lyn Src Cdkn1b Jak2 Ywhaq Ywhah Ywhab Sfn Skp2 Aurka Fbxo5 Cdc14a Rb1 Pttg1 Ppp1cb Clip1 Ncapd2 Ncapg Smc4 Ncaph Smc2 Phf20 Gins2 Gins1 Gins4 Gins3 Ywhaz Cdc25c Cdc25a Npm1 Csnk1a1 Lmna Lmnb1 Tpx2 Plk3 Ppp1r12b Ppp1r12a Cpap Cdkn2b Cdkn2d Actr1a Dctn1 Dctn2 Akt3 Akt2 Akt1 Optn Tert Cnep1r1 Ctdnep1 Emd Ccnb2 Nek9 Ccnb1 Plk1 Lpin3 Lpin2 Vrk1 Vrk2 Prkcb Banf1 Cdk1 Ccnb2-ps2 Mapk1 Rps27a Nudc Mapk3 Ube2n Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Ube2s Ccnd2 Ccne1 Ccne2 Ube2c Ccnd3 Cdc27 Cdc26 Cdc23 Cks1b Anapc10 Anapc16 Cdk6 Anapc15 Anapc5 Anapc4 Anapc1 Golga2 Anapc2 Fzr1 Btrc Anapc7 Ube2e1 Cdc16 Ppp2r5d Pkmyt1 Cop1 Chmp4bl1 Mdm4 Ubb Zfp385a Ubc Gtse1 Exo1 Wee1 Rfc5 Pold2 Rfc3 Cenpe Mapk14 Rfc4 Pcna Rfc1 Chmp2a Rfc2 Pold3 Chmp2b Kpnb1 Ppp2r1b Ppp2r1a Cul1 Ruvbl1 Rab1b Mapk11 Pole3 Pole2 Mcm7 Dync1li2 Mcm8 Pola2 Pola1 Dync1li1 Pole4 Dbf4 Orc5 Orc4 Orc6 Lbr Orc1 Orc3 Orc2 Chtf8 Terf2 Cdt1 Terf1 Gmnn Tinf2 Rpa1 Chtf18 Rpa2 Ctc1 Cdc7 Cdc6 Stn1 Acd Prim2 Terf2ip Rpa3 Cdk2 Ten1 Prim1 Dscc1 Pot1 Mcm3 Mcm4 Mcm5 Mcm10 Pole Mcm2 Ankle2 Itgb3bp Pcnt Ppp6c Prkaca Vps4a Prkca Csnk1d Cep192 Eml4 Tubgcp2 Set Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Lin52 Rab1A Lin54 Cep63 Chmp4c Alms1 Mzt1 Mzt2 Cep43 Phlda1 Cep41 Shq1 Lin37 Tuba1b Dkc1 Ninl Nhp2 Pif1 Rab2a Gar1 Numa1 Tubb5 Wrap53 Odf2 Nop10 Haus7 Rtel1 Haus8 Haus4 Haus5 Haus6 Haus1 Tubgcp6 Tubgcp5 Esco1 Tubgcp4 Pafah1b1 Cdca5 Tubgcp3 Esco2 E2f1 Zw10 E2f2 Pds5b E2f3 Stag2 Cdk11b Stag1 Nedd1 Pds5a Smc1a Ppp2r3b Smc3 Blzf1 Lcmt1 Wapl Ncaph2 Nipbl Obi1 Foxm1 Mau2 Pcm1 Dyrk1a Ssna1 Tubg2 Tubg1 Cables1 Arpp19 Akap9 Cdc25b Ncapd3 Nme7 Dmc1 Sfi1 Ncapg2 Fkbpl Cetn2 Cdkn1c Bora Cep250 Gorasp2 Cep135 Cep131 Cdk5rap2 Mastl Mcph1 Rbl2 Cep152 Lin9 Cep290 Cep164 Ppme1 Ticrr Kif18a Ppp6r3 Ccp110 Dync1h1 Pias4 Mre11 Rsf1 Ube2i Oip5 Mis18a Kat5 Cenpw Mis18bp1 Nbn Hjurp Hus1 Dync1i2 Atrip Dna2 Dync1i1 Blm Phf8 Chek1 Chek2 Ube2v2 Rad9a Kif23 Rad9b Bard1 Top3a Abl1 Sec13 Firrm Clspn Rad17 Clasp1 Clasp2 Spc24 Birc5 Spc25 Rab8a Ercc6l Nuf2 Rangap1 Cdc20 Atm Cdca8 Atr Ankrd28 Incenp Knl1 Ccna1 Mad2l1 Ccna2 Tp53bp1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Fen1 Aurkb Cenpc Lig1 Cenpa Spdl1 Pmf1 Pold1 Ska2 Rmi2 Ska1 Fignl1 Rmi1 Ahctf1 Mapre1 Pold4 Zwint Brip1 B9d2 Ska2l1 Brcc3 H2ab2 Smarca5 Bub1 Herc2 Ppp1cc Taok1 Nde1 Rnf168 Sumo1 Rcc2 H2ac4 Kntc1 ABRAXAS1 Rbx1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Rnf8 Cenpq Kif2c Rhno1 Cenpp Cenpo Wrn Cenpn Nsd2 Cenpm Mis12 Psmb6l1 Rad51 Zwilch SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%10228774 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Diablol1 Xiap Casp7 LAMININ INTERACTIONS%REACTOME%R-RNO-3000157.1 Laminin interactions Megf11 Lama4 Nid2 Itga7 Itga6 Itgb1 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Polr2c Rnmt Polr2a Polr2b Ramac Polr2g Polr2h Polr2e Polr2f Rngtt Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 97%10231046 Protein repair Txn Pcmt1 Msra Msrb1 Msrb3 Msrb2 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane Slc6a12 Slc7a5 Slc38a2 Slc43a1 Slc43a2 Slc6a20 Slc25a29 Slc38a1 Slc38a5 Slc3a1 Slc38a4 Slc1a5 Slc38a3 Slc1a4 Slc7a3 Slc7a11 Slc7a1 Slc6a6 Slc6a19 Slc7a10 Slc6a15 Slc3a2 Slc6a14 Slc36a4 Slc36a2 Slc36a1 Slc16a10 Slc7a6 Slc7a7 Slc7a8 Slc7a9 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%10230598 STING mediated induction of host immune responses Tbk1 Nlrp4 Ddx41 Sting1 Irf3 Stat6 Dtx4 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Vhl Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Pml Pias4 Ube2i Pias2 Sumo1 Nup93 Trim27 Nup50 Nup35 Nup54 Nup98 Pias1 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230868 Intracellular oxygen transport Mb Ngb Cygb ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10229688 ABC transporters in lipid homeostasis Abcd2 Abcd3 Abcg4 Abcg8 Pex3 Abcg5 Pex19 Apoa1 Abca12 Abca2 Abca5 Abca6 Abca3 Abca9 Abca7 Abcd1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-RNO-451308.1 Activation of Ca-permeable Kainate Receptor Dlg1 Calm3 Grik5 Grik2 Dlg3 Grik1 Grik4 Dlg4 Grik3 Ncald MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 97%10231300 MET receptor recycling Met Arf6 Grb2 Rab4b Gga3 Gab1 Crk Rab4a Hgf Crkl RSK ACTIVATION%REACTOME%R-RNO-444257.1 RSK activation Rps6ka6 Rps6ka1 Rps6ka2 Rps6ka3 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-RNO-1236978.1 Cross-presentation of soluble exogenous antigens (endosomes) Psmb8 Psmd8 Psmd2 Psme2 Psme1 Psmb10 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Cd207 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Mrc2 Psmb7 Mrc1 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fcgr1a Psmd7 Psmb9 Psmd6 Psmb6l1 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) Ebp Dhcr24 Dhcr7 INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling Ptpn1 Atp6v0b Ide Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Ptprf Ins1 Atp6ap1 Insr Ctsd Ins2 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%10229500 Regulation of localization of FOXO transcription factors Akt1 Foxo6 Foxo4 Foxo1 Ywhag Ywhaz Ywhaq Akt3 Ywhab Akt2 Sfn Foxo3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-RNO-381119.1 Unfolded Protein Response (UPR) Eif2s3 Eif2s2 Eif2s1 Creb3l3 Atf6b Crebrf Atf6 Mbtps1 Ern1 Eif2ak3 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-RNO-8964539.1 Glutamate and glutamine metabolism Gls2 Gls Oat Rimkla Aldh18a1 Rimklb Glul Pycr3 Pycr2 Got2 Pycr1 Glud1 Kyat1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-RNO-9909649.1 Regulation of PD-L1(CD274) transcription Ash2l H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Eed Rbbp7 Kmt2a Kmt2c H2ac18 Ezh2 H2aj Hist1h2ai H2ab2 H3-3b Hist3h2ba H2ac4 H2bc18 Suz12 Hist1h2bq H2az2 Wdr5 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Chd4 Cdk7 Hdac2 Taf1d H2ac18 Rrn3 Hdac1 Taf1a Taf1c Taf1b Mta1 Mta2 Mta3 Mbd3 Cavin1 Polr1b Polr1c Polr1a Polr1f Polr1g Polr1e Polr1h Chd3 Ubtf Hist1h2bq Gatad2a Gatad2b H2aj H3-3b Hist3h2ba Ttf1 H2bc18 H2az2 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Mapk3 Hist1h2ai Cbx3 Ercc6 Phf6 H2ab2 Polr2h Polr2e Polr2f Mnat1 H2ac4 Gtf2h2 Gtf2h1 Gtf2h3 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231388 RHOB GTPase cycle Pkn2 Pkn1 Anln Rhob Arhgef28 Myo9a Jup Cavin1 Rtkn Iqgap3 Arhgdig Rhpn2 Diaph3 Arhgap21 Rock2 Vav2 Mcam Rock1 Ophn1 Actc1 Arhgap32 Pik3r1 Pik3r2 Flot2 Flot1 Diaph1 Snap23 Tfrc Mcf2l Bcr Arhgef17 Daam1 Arhgef11 Arhgef10 Arhgef12 Akap13 Stom Arhgef25 Arhgap26 Arhgef5 Arhgef2 Racgap1 Arhgef1 Myo9b Vamp3 Arhgap35 Depdc1b Abr Cav1 Ect2 Prex1 Stard8 Dlc1 Stard13 Arhgap5 Mcf2 Arhgap1 Net1 Tjp2 Slk Arhgef10l Stk10 Cit Pcdh7 Sowahc RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10228536 RNA Polymerase III Transcription Tbp Brf1 Gtf3a Polr1c Pou2f1 Polr3a Brf2 Polr3d Snapc3 Polr3e Snapc4 Polr3b Snapc1 Polr3c Snapc2 Polr3f Polr3g Polr3gl Gtf3c2 Crcp Gtf3c1 Gtf3c4 Bdp1 Gtf3c3 Gtf3c6 Gtf3c5 Polr2h Polr2e Polr2f FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%10228758 Formation of apoptosome Cycsl2 Diablol1 Mapk1 Casp9 Apaf1 Xiap Apip Mapk3 Cycs DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-RNO-5696394.1 DNA Damage Recognition in GG-NER Rad23b Nfrkb Cops5 Rps27a Cetn2 Ino80e Ino80d Tfpt Ino80c Ino80b Mcrs1 Actr5 Actr8 Ruvbl1 Uba52 Ino80 Cops7a Cops7b Actg1 Cops3 Actl6a Cops4 Cops6 Ddb1 Cul4a Parp2 Gps1 Cops2 Parp1 Cul4b Ddb2 Cops8 Ubb Ubc Rbx1 Yy1 Xpc Rad23a APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 97%10229188 APC C:Cdc20 mediated degradation of Securin Pttg1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69473.1 G2 M DNA damage checkpoint Rad50 Cdc25c Babam1 Babam2 Topbp1 Rbbp8 Brca1 Ywhae Uimc1 Rad1 Ywhag Hist1h2bq Rpa1 Rpa2 Tp53 Rpa3 Pias4 Ccnb1 Mre11 Kat5 Hist3h2ba Nbn Cdk1 Hus1 Atrip Dna2 Blm Chek1 Chek2 H2bc6 Ube2v2 Rad9a Rad9b H2bc4 Bard1 Hist1h4m Top3a H2bc1 Ube2n Rad17 Atm Atr Ccna1 Ccna2 Tp53bp1 Rmi2 Ywhaq Rmi1 Ywhah Ywhab Brip1 Brcc3 Sfn Herc2 Rnf168 Exo1 ABRAXAS1 Wee1 Rfc5 Ywhaz Rnf8 Rfc3 Rhno1 Rfc4 Wrn Nsd2 Rfc2 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-RNO-561048.1 Organic anion transport by SLC22 transporters Slc22a12 Slc22a6 Slc22a8 Slc22a7 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 97%10229992 Sodium Proton exchangers Slc9a2 Slc9a3 Slc9a8 Slc9a9 Slc9a6 Slc9a1 Slc9a7 Slc9a4 Slc9a5 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-RNO-442742.1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Rps6ka6 Rps6ka1 Rps6ka2 Rps6ka3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230384 PI3K events in ERBB4 signaling Ereg Hbegf Btc Nrg2 Nrg1 Nrg3 Pik3ca Pik3r1 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%10230528 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Cd28 Pip4k2b Ppp2r1b Pip4k2c Ppp2r1a Pip4k2a Cd86 Cd80 Strn Egfr Esr1 Esr2 Kl Gab1 Flt3 Rhog Fgf10 Fgf3 Fgf22 Fgf7 Rac1 Ppp2r5b Trat1 Ppp2r5a Ntf3 Ntf4 Ppp2r5e Kit Ntrk2 Insr Bdnf Pip5k1a Src Fgfr3 Egf Kitlg Lck Pik3r5 Pik3r6 Pik3cg Icos Ier3 Hgf Pdgfrb Pdgfra Met Ntrk3 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Ins1 Fgf6 Fgf5 Fgf8 Ins2 Fgf9 Klb Fgf19 Fgfr4 Ereg Grb2 Fyn Fgfr1 Pdgfa Pdgfb Btc Cd19 Akt1 Il1rap Gab2 Vav1 Pik3r1 Pik3r2 Erbb2 Pik3r3 Pip5k1b Il33 Tgfa Erbb3 Nrg2 Nrg1 Nrg3 Traf6 Mapk1 Hbegf Mapk3 Pik3ap1 Rac2 Irs1 Irs2 Ppp2cb Ppp2ca Areg Frs2 Irak4 Pik3cb Pik3cd Pik3ca Myd88 Ppp2r5d Il1rl1 Pip5k1c Ptpn11 Irak1 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%10229676 Insulin processing P4hb Slc30a8 Ins1 Ins2 Ero1b Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Slc30a5 Exoc7 Exoc8 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%10230942 VxPx cargo-targeting to cilium Cnga4 Rab3ip Pkd1 Cnga2 Asap1 Rho Gbf1 Cngb1 Exoc3 Exoc4 Exoc5 Exoc6 Rab8a Rab11a Exoc1 Exoc2 Arf4 Exoc7 Exoc8 Thoc2l RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%10231532 Recognition and association of DNA glycosylase with site containing an affected purine Terf2 Terf1 H2bc6 Tinf2 Neil3 H2bc4 Hist1h4m Acd H2bc1 Terf2ip H2ac18 Pot1 H2aj Hist1h2ai H2ab2 Hist3h2ba Ogg1 H2ac4 Hist1h2bq H2az2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229682 Peptide hormone biosynthesis Inhbc Inhba Inha Inhbe Lhb Tshb Pomc Pcsk1 Fshb Cga Inhbb NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-9974237.1 Negative Regulation of DNA Double Strand Break Response Psmd8 Psmd2 Bard1 Rps27a Psmd1 Adrm1 Psma4 Psma3 Brca1 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Ddb1 Psmb7 Psmb6 Cul4a Psmb1 Psmb3 Psmb2 Cul4b Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Psmd7 Psmd6 Psmb6l1 RHOBTB3 ATPASE CYCLE%REACTOME%R-RNO-9706019.1 RHOBTB3 ATPase cycle Vhl Htr7 Hgs Lrrc41 Rab9a Ccne1 Rab9b Cul3 Rhobtb3 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Tfap2a Npm1 Atad2 Cited1 Ep300 Cga Esr1 Myc Ube2i Cited2 Cited4 Tfap2e Crebbp Dek Tfap2c Sumo1 Wwox Tfap2b Lhb Yeats4 Kctd1 Kdm5b SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 97%10231366 Signaling by ROBO receptors Myo9b Rhoa DEPURINATION%REACTOME%R-RNO-73927.1 Depurination Terf2 Terf1 H2bc6 Tinf2 Neil3 H2bc4 Hist1h4m Acd H2bc1 Terf2ip H2ac18 Pot1 H2aj Hist1h2ai H2ab2 Mpg Hist3h2ba Ogg1 H2ac4 Mutyh Hist1h2bq H2az2 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME DATABASE ID RELEASE 97%10230610 Processing of antigen in germinal center B cells Actr1a Dynll1 Dynll2 Rilp Kif3a Ctsa Kif3b RT1-DOa RT1-DOb Dctn1 Osbpl1a Kif3c Dctn2 Dctn4 Klc1 Dync1li2 Dync1li1 Klc4 Klc3 Klc2 Kif18a Ctsc Kif20a Rab7a Dync1h1 Kifap3 Kif11 Kif15 RT1-Db2 RT1-Db1 Dync1i2 RT1-Ha Dync1i1 RT1-Ba RT1-Bb Kif22 RT1-Da Kif23 Racgap1 Kif4b Kif4a Kif26a Ctsb Ctsd Actr10 Ctse Kif5a Sptbn2 Ctsf Kif5b RT1-DMb Actr1b Ctsh Ctsk Ctsl Ctso Ctss Ifi30 Kif2a Kif2b Kif2c Cenpe MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%10229016 Mitochondrial Uncoupling Slc25a4 Slc25a27 Ucp1 Ucp2 Ucp3 Slc25a14 Pm20d1 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%10229232 Chylomicron remodeling Apoc2 Apoc3 Apoa2 Apoe Apoa4 Gpihbp1 Apoa5 Apoa1 Apob Lpl DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption Alpi Gucy2c Pir Guca2b Npc1l1 Guca2a Chit1 Slc2a2 Si Slc5a1 Amy2 Slc2a5 Lct Chia Clps Pnlip Lipf Cel Pnliprp2 Pnliprp1 PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 97%10230900 Phase 2 - plateau phase Akap9 Cacng8 Cacng4 Cacng6 Cacng7 Cacna1c Kcne5 Kcnq1 Kcne4 Kcne3 Kcne2 Cacna2d2 Cacnb1 Cacnb2 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation Ogdh Grhpr Hao1 Dao Agxt2 Ddo Gcsh Aldh4a1 AC132020.1 Dld Gnmt Prodh2 Dlst Agxt Got2 Amt Kgd4 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing Gsdmd Il1a Il1b Ctsg Rela Nfkb2 Il18 Nfkb1 Casp1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle Slc1a6 Gls2 Syt1 Gls Vamp2 Stxbp1 Unc13b Cplx1 Rims1 Stx1a Rab3a Arl6ip5 Ppfia3 Snap25 Tspoap1 Ppfia2 Ppfia4 Ppfia1 Slc17a7 Slc1a1 Slc1a3 Slc1a2 Slc38a2 Slc1a7 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 97%10231232 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmd8 Psmd2 Aurka Rps27a Cul1 Psmd1 Fbxl7 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Psmd7 Psmd6 Psmb6l1 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-RNO-418555.1 G alpha (s) signalling events Pde4a Prkaca Prkacb Pde3a Prkar1a Pde7a Grk5 Prkar1b Grk6 Pde8a Pde8b Grk2 Arrb2 Shc1 Pde4c Itgb1 Pde4d Prkar2a Pde1b Pde3b Adrb2 Pde1a Pde10a Pde11a Arrb1 Pde2a Grk3 RHO GTPASE EFFECTORS%REACTOME%R-RNO-195258.1 RHO GTPase Effectors Cenpl Cenpk Cdc25c Dynll1 Cenpi Dynll2 Cenph Cenpf Ndc80 Rhoc Rhob H2ac18 Ywhae Ywhag Hist1h2bq Pik3c3 Ctnnb1 Ppp2r5b Ppp2r5a Dvl1 Dvl3 Wipf3 Wipf1 Btk Pik3r4 Ppp2r5e H2aj Nckipsd Limk1 H3-3b Hist3h2ba H2bc18 H2az2 H2bc6 H2bc4 Hist1h4m H2bc1 Hist1h2ai Kdm4c Ppp1r12b Ppp1r14a Ar Ppp1r12a Ptk2 Grb2 Cftr Rps27 Kdm1a Plk1 Prkcb Diaph1 Daam1 Pfn1 Mapk1 Nudc Mapk3 Rac2 Kif14 Ppp2cb Ppp2ca Ktn1 Ppp2r5d Ncf1 Ncf2 Ncf4 Brk1 Cenpe Mapk14 Baiap2 Nck1 Nckap1l Nup98 Nckap1 Nup37 Ppp2r1b Ppp2r1a Nup107 Prkcz Wasf3 Nup160 Wasf2 Wasf1 Mapk11 Nup85 Abi2 Klc1 Cyba Dync1li2 Abi1 Nup43 Rhog Cybb Cyfip2 Dync1li1 Cyfip1 Xpo1 Klc4 Pdpk1 Rac1 Klc3 Ranbp2 Diaph3 Klc2 Dvl2 Nup133 Arpc3 Arpc2 Rhoa Arpc5 Itgb3bp Arpc4 Pak1 Srgap2 Pak2 Prkcd Prkca Mrtfa Calm3 Mylk Gopc Flna Nox3 Nox1 S100a9 S100a8 Ywhaq Ywhah Noxa1 Ywhab Pafah1b1 Sfn Evl Cit Zw10 Srf Prc1 Fmnl1 Noxo1 Pfn2 Pkn2 Pkn1 Actr2 Actb Actr3 Arpc1b Arpc1a Rhoq Scai Ppp1cb Clip1 Cdh1 Ctnna1 Rtkn Iqgap2 Rhpn1 Iqgap3 Men1 Rhpn2 Pak3 Kif18a Lin7b Actg1 Ncoa2 Cdc42 Rock2 Rock1 Dync1h1 Dlg4 Fmnl2 Fmnl3 Dync1i2 Dync1i1 Abl1 Sec13 Clasp1 Clasp2 Spc24 Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Kif5a Mapre1 Zwint Kif5b B9d2 Ska2l1 H2ab2 Bub1 Ppp1cc Taok1 Nde1 Rcc2 H2ac4 Kntc1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Ywhaz Cenpq Kif2c Cenpp Cenpo Cenpn Cenpm Mis12 Zwilch CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%10230584 Crosslinking of collagen fibrils Loxl2 Bmp1 Loxl1 Loxl4 Tll2 Loxl3 Lox Tll1 Pxdn Pcolce NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%10229780 Nuclear Receptor transcription pathway Nrbf2 Esr1 Nrbf2l1 Esr2 Vdr Rara Ppard Rorc Rorb Nr1h4 Ncor2 Med1 Rarg Pparg Nr5a2 Nr6a1 Esrra Esrrb Esrrg Hnf4a Hnf4g Nr5a1 Nr4a3 Nr4a2 Ppara Nr3c2 Nr3c1 Nr2c2 Nr2c1 Nr4a1 Nr1d2 Nr1d1 Nek4 Ar Nr2f6 Nr0b2 Nr0b1 Thrb Nr2f1 Thra Nr1h3 Nr2e3 Nr1h2 Rxrb Nr1i3 Rxra Nr1i2 Pgr Rxrg METABOLISM%REACTOME DATABASE ID RELEASE 97%10228234 Metabolism Suclg2 L2hgdh Cs Adipoq Tkt Fh Chp1 Pgd Ubiad1 Prps1 Prps2 Abo2 Sdhaf1 Sdhaf2 Sdhaf3 Gys1 Adipor2 Adipor1 Galk1 Dcxr Marcks Fam20b Aco2 Aco1 Vkorc1 Pgm2 Taldo1 Xylt1 Xylt2 Pik3c3 Pgls B3galt1 Papss2 Papss1 Sdhd Sdhc Sdhb Sdha Them4 Shpk Car7 Pik3r4 B3galt6 B3galt5 Mlxipl Cryl1 Prps1l3 Gale Galm Sucla2 Ttpa Ch25h Amacr Hsd17b4 Osbpl3 Slco1a4 Osbpl2 Osbpl7 Osbpl6 Baat Osbpl9 Hsd3b7 Scp2 Akr1d1 Slc10a1 Acox2 Fabp6 Stard5 Acot8 Alb Osbp Slc27a5 Slc51a Slc27a2 Slc51b Abcb11 Ippk Ipmk Ip6k1 Ip6k2 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Mtm1 Fig4 Vac14 Mtmr12 Mtmr4 Pi4k2a Morc2 Rap1a Spr Gch1 Pts Gchfr Arsa Smpd2 Smpd3 Smpd4 Smpd1 Gba1 Gba3 Gba2 Enpp7 Neu2 Galc Asah2 Neu3 Asah1 Neu4 Sts Gm2a Neu1 Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 Med1 Pla2g4b Lpcat3 Lpcat4 Abhd4 Pnpla8 Plaat1 Pla2g3 Plaat5 Mboat1 Mboat2 Lpl Apoc2 Apoc3 Apoa2 Apoe Apoa4 Alox12 Gpx4 Hpgd Alox5 Lta4h Alox15 Gstm4 Cyp2c66 Cyp2c11 Cyp2e1 Cyp1a1 Ephx2 Cyp1a2 Ltc4s Ptgs2 Gpx2 Aloxe3 Gpx1 Alox12b Lrp1 Sdc4 Sdc3 Lrp8 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Bco2 Gpc4 Bco1 Gpc6 Agrn Clps Pnlip Rbp4 Apom Rbp2 Rbp1 Lrat Ca1 Ca2 Ca4 Rapgef4 Rapgef3 Fabp1 Gsta5 Blvrb Hmox1 Hmox2 Blvra Ugt1a1 Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Acer3 Plpp2 Sgpp2 Plpp3 Plpp1 Slc35d2 Sgpp1 Slc35d1 Slc35b3 Slc35b2 Slc26a2 Slc26a1 Slc26a11 Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Acss2 Rps27a Idh2 Sirt3 Oxct2a Bdh1 Oxct1 Ecsit Uba52 Sin3a Sin3b Ubb Ubc Amn Mapkapk2 Cubn Kpnb1 Ptgs1 Shmt2 Lbr Pld1 Plcb4 Plcb3 Pla2g4a Plcb2 Plcb1 Gng10-ps1 Adcy5 Adcy6 Prkaca Prkacb Gnai2 Gnai1 Prkca Gna11 Prkar1a Gna14 Prkar1b Calm3 Gng3 Pomc Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Prkar2a Pld2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Aldh3a2 Abcd1 Abcd3 Acbd5 Abcc8 Alpi Kcnb1 Kcns3 Kcnc2 Gpihbp1 Kcng2 Bmx Folr2 Bst1 Vnn1 Ppa1 Ppa2 Lhpp Plpp6 Fdps Idi1 Hsd17b7 Slc2a2 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Acat2 Nsdhl Dhcr24 Dhcr7 Lss Srebf2 Tm7sf2 Pmvk Hmgcr Mvd Psmb6l1 Msmo1 Srebf1 Prkag2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 B3gnt3 Csnk2a2 Csnk2a1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cd36 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Prkab2 Inpp5e Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Cox7a2l Cox6a1 Cox6a2 Tmem126b Uqcrfs1 Nubpl Rnf113a1 Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Higd1c Coxfa4 Cox20 Cox6c2 Cycsl2 Cyc1 Got1 Got2 Hspa9 Cox6b1 Cox8a Cox6b2 Ndufv2 Ndufv1 Cox8c Yjefn3 Ndufv3 Uqcrb Cox18 LOC120097699 Mt-cyb Tmem177 Uqcrh Ndufab1 Ndufc2 Ndufa12 Ndufa11 Ndufa10 Cox7b Ndufs1 Timmdc1 Ndufs3 Ndufs2 Slc25a22 Ndufs5 Cox4i1 Ndufs4 Cox4i2 Ndufs7 Ndufs6 Mt-co3 Cox7c Ndufs8 Mt-co2 Cycs Slc25a18 Slc25a11 Slc25a12 Slc25a13 Fxn Ndufa5 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Nfs1 Cox7a1 Cox7a2 Cox5a Cox5b Mt-co1 Mdh1 Mt-nd5 Mdh2 Mt-nd4 Mt-nd6 Ndufb1 Lyrm7 Hscb Mt-nd1 Ndufb3 Hccs Uqcrc2 Etfb Uqcrc1 Mt-nd3 Lyrm4 Ndufb5 Mt-nd2 Etfa Ndufb8 Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Uqcr10 Ttc19 Gnpda1 Gpi Gnpda2 Eno3 Eno2 Eno4 Pfkfb4 Pfkfb3 Pfkfb2 Pfkfb1 Pc Pgam2 Pgam1 Slc37a4 Tpi1 Slc37a2 Slc37a1 Hkdc1 Fbp1 Fbp2 Gckr Pklr Gapdhs Aldoc Bpgm Aldoa Pfkl Pgk1 Pgk2 Pck1 Pfkm Sptlc1 Pfkp Mfsd2b Pck2 Pgm2l1 Sptlc2 Sptlc3 G6pc1 Pkml1 Ormdl2 Gck Sptssa Degs2 Hk2 Hk3 Ormdl3 Degs1 Adpgk G6pc3 Cers6 Tpi1l2 Cers5 Cers4 Abcg2 Cers3 Cers2 Fa2h Cyb5b Isca2 Abcc1 Glrx5 Isca1 Sphk2 Sgms1 Spns2 Sphk1 Sgms2 Kdsr Pik3r5 Pik3r6 Pik3cg Slc9a1 Nos3 Prkg2 Itpr1 Sdc1 Pik3r1 Pik3r2 Pik3r3 Inppl1 Inpp5d Pik3cb Pik3cd Pik3ca Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Xdh Itpa Dnph1 Nt5c2 Arf1 Nudt5 Ocrl Acoxl Crot Acox3 Idua Ncan Bgn Cspg5 Cspg4 Vcan Hyal4 Hyal3 Ids Hyal1 Gusb Dnm2 Pld4 Cds2 Rrm2b Txn Dtymk Nudt13 Dut Rrm1 Tyms Rrm2 Ak1 Gsr Nme3 Pik3c2a Nme2 Ak2 Ak5 Glrx Ak4 Ak7 Ak6 Nme1 Ak9 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 Itpr3 Itpr2 Ranbp9 Abcc3 Abcc2 Abcc5 Apoa1 Kcnj11 Hsd3b Cyp17a1 Hsd3b6 Serpina6 Hsd3b5 Hsd3b1 Hsd3b5-ps1 Hsd11b1 Hsd11b2 Akt1 Gns Pip5k1b Arf3 Cbr1 Tbxas1 Hpgds Ptges Ptgds Ptgis Ptges2 Osbpl5 Pla1a Osbpl8 Osbpl10 Pip5k1c Ldlrap1 Rab5a Rab4a Hs3st4 Hs3st1 Extl2 Hs3st2 Naglu Hs3st5 Hs3st6 Hs3st3b1 Synj1 Hpse2 Hpse Hs2st1 Ndst1 Ndst2 M6pr Ndst3 Ndst4 Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Sgsh Ext2 Synj2 Ext1 Vdac1 Mtmr1 Lrp2 Rab14 Agpat3 Apob Acads Sec13 Pla2g6 Sbf1 Pten Nampt Pdxk Naxe Slc52a2 Slc52a3 Lrpl1 Btd Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Cblif Tcn2 Fpgs Mmut Mthfs Mthfr Slc25a32 Slc46a1 Slc23a1 Mthfd1l Slc23a2 Naprt Slc2a1 Mmadhc Gsto1 Pcca Slc2a3 Gsto2 Rfk Dcakd Pccb Acp5 Aox1 Ppcdc Coasy Nadk2 Nudt12 Mthfd2l Nmrk1 Cyb5a Mocs3 Slc25a16 Ppcs Hlcs Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Flad1 Mmab Rnls Enpp1 Mocs1 Mmachc Slc22a13 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Mthfd2 Gphn Pank3 Pank2 Pank4 Mocos Pank1 Ces1d Ppara Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Nup205 Pom121 Nup107 Nup188 Tgs1 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Lhb Pi4kb Pi4ka Pik3c2g Tpte2 Sacm1l Tymp Cda Upp1 Upp2 Pudp Tk2 Uck1 Uck2 Cga Chst11 Chst12 Chsy1 Chsy3 Chst13 Chst14 Chst15 Dse Chpf Csgalnact2 Chst7 Chst9 Dsel Ust Mt-atp8 Mt-atp6 Gcgr Gcg Adra2a Adra2c Atp5mc1 Atp5f1e Atp5f1d Atp5pb Atp5f1c Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Phyh Eci2 Hacl1 Gstk1 Mlycd Gnpat Acox1 Ffar1 Ehhadh Acaa1b Coq2 Hao2 Pecr Idh1 Decr2 Nudt19 Acot1 Acot2 Gnas Acot5 Acot3 Acot4 Agps Hmgcl Acbd4 Mbtps1 Cyp2s1 Miox Ip6k3 Isyna1 Itpka Itpkc Itpkb Impa2 Impa1 Inpp5a Inpp5b Plch1 Plcd1 Inpp5j Plcd4 Plcd3 Itpk1 Nudt4 Nudt3 Minpp1 Plcz1 Plce1 Inpp1 Ppip5k1 Ppip5k2 Psap Glp1r Tshb Lpin3 Lpin2 Nosip Ptpn13 Cav1 Slc25a27 Ucp1 Ucp2 Ucp3 Slc25a14 Ctsl Acsl3 Acsl4 Phkg1 Phkg2 Gaa Agl Pygl Pygm Phkb Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Ctsa Osbpl1a Plcg1 Plcg2 Mtmr14 Mtmr3 Cyp3a9 Pon3 Pon1 Slco1b2 Slco2b1 Ugt1a2 Dgat2 Ugt1a3 Gk Ugt1a5 Gpam Cyp3a18 Dgat1 Cyp3a1 Agmo Cyp3a62 Mogat1 Cyp3a2 Gpat2 Aldh1a1 Mogat2 Gykl1 Tkfc Glyctk Sord Aldob Akr1b1 Acadm Khk Pm20d1 Alox5ap Lgmn Pdss2 Coq8a Coq8b Pdss1 Coq3 Coq4 Coq5 Coq6 Hpdl Coq7 Coq9 Stard7 Sdc2 Upb1 Nt5c3a Dpys Dpyd Nt5m Cyp2u1 Uxs1 Sult1c2 Bpnt2 Bpnt1 Glyatl3 As3mt Cyp2w1 Sult1b1 Ugt1a6 Pias4 Ugt1a7 Ugt1a8 Ube2i Chac1 Chac2 Gstm7 Adh6 Gstm5 Adh5 Gstm1 Cyp27b1 Gstm2 Acsm2 Acsm4 Acsm5 Sult1a1 AC114845.1 Ugt2b7 Cmbl Ephx1 Akr1a1 Acy3 Aldh3a1 Aadac Sult6b1 Ugt2a1 Ugt2a3 Ugt2b1 Ugdh Maob Gstp1 Gsta6 Gsta3 Acy1a Gsta1 Gsta2 Ugt3a1 Cbr3 Sult1e1 Aoc3 Nqo2 Gss Fmo3 Fmo2 Cyp2c24 Tpst1 Tpst2 Akr7a3 Akr7a2 Abhd14b Ggt1 Sult4a1 Ugt2b34l1 Ugt2b Ugt2b17 Gstt2 Ugt2b15 Gstt1 Dpep1 Dpep2 Ggct Gclc Esd Cndp2 Gclm Abhd10 Ggt5 Ggt7 Ggt6 Tpmt Nat1 Nat2 Nat3 Sumo3 Ugt2b37 Oplah Sult2b1 Acss1 Mtarc2 Mgst3 Mgst2 Mgst1 Sult2a2 Sult2a1 Sult2a6 Cyp24a1 Podxl2 Ces2h Mat2a Mat2b Ugp2 Aldh1b1 Bphl Ran Pcyt2 Etnk2 Cept1 Etnk1 Etnppl Chka Chkb Selenoi Phospho1 Gpc5 Aanat Tph2 Mgll Ddc Tph1 Asmt Dguok Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Gmpr Adk Hprt1 Dck Aprt Ada Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 Pdhx Akr1c18 Akr1c19 Hsp90aa1 Cyp26b1 Akr1c21 Pdk4 Pdk3 Pdk2 Pdk1 Pdhb Hsp90ab1 Rxra Akr1c12 Cyp26a1 Akr1c13 Mecr Ptdss1 Ptdss2 Gpd1l Hacd1 Hacd2 Rdh11 Hacd3 Hacd4 Tbl1x Lpgat1 Far2 Adh4 Far1 Pip4k2b Pdha1 Pip4k2c Adh1 Pip4k2a Pdha2 Pitpnb Mcat Acad11 Ugt8 Pik3c2b Liph Lipi Mtmr7 Ppt2 Mtmr6 Crebbp Ppt1 Akr1c3l1 Mtmr9 Mfsd2a Slc25a20 Gpat4 Gpat3 Hdac3 Aacs Acot9 Acot7 Bdh2 Rufy1 Tbl1xr1 St8sia5 Pnpla5 Pnpla6 Pnpla3 Zdhhc21 Pnpla4 Ppard Enpp6 Pnpla2 Tafazzin Agk Ptges3 Akr1c1 Tspo Gc Akr1c9 Pip5k1a Dld Ncor2 FABP12 Carm1 Pcyt1b Pcyt1a Abhd3 Hsd17b12 Akr1c12l1 Hsd17b13 Fitm2 Fitm1 Tnfaip8l2 Tnfaip8l3 Tnfaip8l1 Fabp5 Pgp Inpp5k Elovl2 Cyp26c1 Dlat Acly Elovl3 Elovl5 Elovl1 Elovl6 Elovl7 Tecrl Awat2 Awat1 Acss3 Acp6 Them5 B3galnt1 Acadvl B4galnt1 Gal3st1 Cpt1a Ddhd2 Cpt1b Agpat4 Agpat1 Agpat2 Slc44a3 Slc44a4 Slc44a5 Eci1 Gde1 Cerk Cds1 Hsd17b8 Mid1ip1 Slc22a5 Hsd17b3 Dhrs7b Cpne1 Cpne3 Star Cpne6 Cpne7 Pemt Cidea Cidec Pip4p1 Faah Pitpnm2 Cyp2j16 Pitpnm3 Pitpnm1 Cyp4f39 Adh7 Stard4 Stard6 Cyp2j3 B3gnt5 Cyp4f1 Cyp2f2 Decr1 Acot11 Cyp4a14 Cyp2b1 Scd1 Acot12 Cyp4f3 Acot13 Cyp4f40 Plekha8 Cyp4a12 Plekha6 Cyp4b1 Plekha5 Cyp2a2 Plekha4 Cyp4f4 Plekha3 Cyp4a10 Plekha2 Cyp2a1 Cyp2d4 Plekha1 Acsl1 Cyp4a2 Cyp2a3 Lpcat1 Glb1l Scap B3gnt7 Acsl5 B3gnt2 Acsl6 Kera Ugcg B4galt4 Fads2 B4galt5 Lpcat2 B4galt6 Hmgcll1 Prelp Fads1 Cbr4 Glb1l3 Fabp2 Fmod Fabp3 Glb1l2 Fabp4 St3gal6 Fabp7 Galns Tecr St3gal4 St3gal2 Acsbg1 Hexa Acsbg2 Fabp9 Lum Hexb Srd5a3 St3gal3 Srd5a1 B4gat1 Srd5a2 Omd St6galnac5 St3gal1 St6galnac6 Chst1 Miga2 Pla2g15 Chst3 Chst2 Miga1 B4galt2 Gpd2 B4galt3 Gpd1 Acan B3galt4 Chst6 Pld6 Fut2 Glb1 Ogn Fut1 Dgat2l6 Acaa2 Vdr Acbd6 Acsf3 Acsf2 Arnt Dbi Ahr A4galt Cyp39a1 Cpt2 Hmgcs2 Cyp19a1 Ncoa2 Pon2 Tmem86b Cyp11a1 Cyp1b1 Cdipt Ahrr Alox15b Cyp51a1 Lclat1 St3gal5 Cyp8b1 Chpt1 Cyp7b1 Nr1h4 Pctp Cyp4v2 Thrsp Cyp21 Stard10 Cyp46a1 Tnfaip8 Cyp27a1 Arnt2 Cyp11b1 Fdx1 Cyp11b3 Cyp11b2 Fdxr Fdx2 Cyp7a1 Slc17a5 Dcn B4galnt2 Bcan Phykpl Cd44 Gamt Ckmt1 Ckmt2 Slc44a1 Slc44a2 Gls Mtap Dmgdh Tdo2 AC132020.1 Shmt1 Sds Slc6a11 Slc6a12 Mccc1 Tyrp1 Mccc2 Ido2 Hpd Ido1 Slc45a2 Pycr3 Pycr2 Aldh6a1 Slc22a4 Pycr1 Glud1 Kyat1 Oaz1 Oaz3 Oaz2 Dhtkd1 Ogdh Hao1 Asl Slc5a5 Mtrr Pnmt Tyr Gcsh Hal Hykk Adi1 Pah Glul Prodh1 Acadsb Prodh2 Gpt Phgdh Ado Bhmt Th Auh Aadat Bhmt2 Agmat Slc25a21 Gcdh Folh1 Slc6a8 Arg2 Slc6a7 Arg1 Txndc11 Sdsl Enoph1 Slc25a15 Ivd Aass Slc25a10 Oca2 Oat Aldh4a1 Sqor Odc1 Hdc Gnmt Gatm Bbox1 Ckb Nqo1 Duox1 Ahcy Slc7a5 Aoc1 Ckm Fmo1 Sephs2 Fah Duox2 Kgd4 Echs1 Asrgl1 Otc Slc25a2 Amdhd1 Aldh9a1 Sat1 Txn2 Hsd17b10 Iyd Acat1 Serinc4 Serinc5 Crat Serinc2 Aldh18a1 Hgd Serinc1 Haao Gpt2 Dio1 Dio2 Dlst Dio3 Kmo Acad8 Rida Pipox Carns1 Sirt5 Mpst Naalad2 Mri1 Cps1 Tpo Qdpr Glyat Grhpr Duoxa1 Duoxa2 Dao Agxt2 Hibadh Azin2 Gadl1 Psph Azin1 Rimkla Rimklb Tat Amd1 Asns Aldh7a1 Mtr Dbh Bcat1 Nat8l Bcat2 Txnrd1 Dbt Hibch Ethe1 Pcbd1 Amt Carnmt1 Bckdhb Dct Tst Bckdha Gstz1 Crym Smox Gls2 Psat1 Suox Ddo Srm Il4i1 Srr Cbs Aspg Scly Slc3a2 G6pdx Slc36a4 Nags Aspa Agxt Bckdk Usf1 Tmlhe Uroc1 Chdh Ftcd Kynu Cth Sardh Mat1a Ppm1k Cdo1 Hyal5 Hadha Hadhb Acadl Hadh Fech Uros Ppox Cox10 Alad Alas1 Alas2 Cox15 Hmbs Lypla1 Cpox Urod Smarcd3 Ldhal6b Glo1 Wdr26 Hagh Nek1 Mkln1 Fahd1 Gid4 Maea Ldha Ldhb Ldhc Me1 Armc8 Me3 Me2 Rmnd5b Ddah1 Nostrin Cygb Dhodh Adsl Impdh2 Cad Impdh1 Gmps Adss2 Adss1 Pgam5 Pfas Atic Umps Pdp1 Ppat Gart Pdpr Paics Pdp2 Crls1 Tspoap1 Maoa Cacna2d2 Cacnb3 Cacnb2 Cacna1e Cacna1a Comt Chat Aldh2 Akr1b10 Hsd17b11 Slc25a4 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Entpd1 Entpd2 Cacna1c Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 Galt Man2c1 Man2b1 Idh3B Samhd1 Rpe D2hgdh Idh3g Idh3a Gbe1 Nnt Dera Hyal2 Cacna1d Rbks Adhfe1 Xylb Chp1l1 Vkorc1l1 Has1 Has2 Has3 Cemip Pxylp1 Trap1 Ppp1r3c B4galt7 Manba Ca12 Ca14 Ca13 Fut4 Fut7 Fut9 Ca3 Ca6 Ca9 Rpia Ca5b Ca5a Suclg1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 97%10230298 Serine metabolism Phgdh Sdsl Psat1 Serinc4 Serinc5 Psph Srr Serinc2 Sds Serinc1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 97%10229568 G-protein beta:gamma signalling Pik3cg Arhgef6 Akt3 Akt2 Akt1 Gng3 Gng5 Pdpk1 Gng4 Gng7 Gng8 Cdc42 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Rhoa Pak1 Gng10-ps1 Pik3r5 Pik3r6 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-RNO-113501.1 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Ppp2cb Ppp2ca Ppp2r1b Ppp2r3b Prim2 Ppp2r1a Pola2 Rb1 Pola1 Prim1 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%10231684 Regulation of endogenous retroelements Zfp719 Zfp950l5 H2bc6 H2bc4 Hist1h4m Mphosph8 H2bc1 ENSRNOG00000070049 H2ac18 Hist1h2ai Zfp317 Zfp758 Zfp52 Zfp964 Hist1h2bq Znf354a Znf431l2 Tasor Morc2 Setdb1 LOC102546572 Atf7ip Pphln1 ENSRNOG00000065205 Cbx5 Znf624l H2aj Trim28 H2ab2 H3-3b Hist3h2ba Znf382 H2ac4 Zfp324 LOC120095871 H2bc18 Rex2l4 Zfp808l3 Zfp867 H2az2 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 Psmd8 Psmd2 Chek2 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Atm Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Phf20 Psmb2 Psma7 Psmc5 Cop1 Ubb Mdm4 Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis Cops5 Syt2 Tor1b Syt1 Ldlrap1 Syt9 Syt8 Eps15 Egfr Picalm Scarb2 Ldlr Stam2 Dab2 Clta Ubqln2 Cltc Necap1 Chrm2 Vamp8 Ubqln1 Epn2 Dvl2 Epn1 Cops3 Cops4 Cops6 Cops2 Sh3gl2 M6pr Cops8 Arrb1 Egf Reps1 Ttgn1 Aak1 Reps2 Igf2r Cd3g Syt11 Cd3d Slc2a8 Cd4 Tfrc Ap2m1 Sh3gl3 Sh3kbp1 Sh3gl1 Grk2 Lrp2 Arrb2 Fcho1 Fcho2 Ereg Grb2 Cftr Necap2 Avpr2 Btc Stam Slc18a3 Agfg1 Itsn1 Cops7a Apob Cops7b Itsn2 Vamp7 Vamp2 Tf Fzd4 Tgfa Avp Hbegf Cltb Rps27a Ap2b1 Agtr1 Vamp3 Areg Uba52 Vamp4 Nedd8 Wnt5a Adrb2 Gps1 Ston1 Ston2 Ubb Ap2a2 Ap2a1 Ubc Ap2s1 Hgs Eps15l1 Tacr1 Il7r Cbl Grk3 Tor1a Snap91 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-RNO-9958863.1 SLC-mediated transport of amino acids Slc6a12 Slc7a5 Slc1a1 Slc1a3 Slc1a2 Slc38a2 Slc1a7 Slc43a1 Slc43a2 Slc1a6 Slc6a20 Slc25a29 Slc38a1 Slc38a5 Slc3a1 Slc38a4 Slc1a5 Slc38a3 Slc1a4 Slc7a3 Slc7a11 Slc7a1 Slc6a6 Slc6a19 Slc7a10 Slc6a15 Slc3a2 Slc6a14 Slc36a4 Slc36a2 Slc36a1 Slc16a10 Slc7a6 Slc7a7 Slc7a8 Slc7a9 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629594.1 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrnb2 Chrna4 Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrnb4 Chrnb3 Chrna9 Chrna3 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases Atp1a2 Fxyd3 Fxyd4 Atp1a1 Atp1a4 Fxyd1 Fxyd2 Atp1a3 Fxyd7 Fxyd6 Pln Atp7b Atp10a Atp10b Atp10d Atp4a Atp4b Atp11b Atp11a Atp1b1 Atp13a1 Atp1b3 Atp11c Atp1b2 Atp8b2 Camk2g Atp8b1 Camk2d Atp8b4 Camk2b Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a Atp2c1 Atp2c2 Atp2a1 Atp9b Atp2b1 Atp9a Atp2b4 Atp2a3 Atp2b3 Atp2a2 Camk2a Calm3 Adam22 Atp7a REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-RNO-6804756.1 Regulation of TP53 Activity through Phosphorylation Prkag1 Rad50 Tbp Prkag2 Mapkapk5 Taf4b Aurka Taf7l-ps1 Topbp1 Rbbp8 Taf8 Taf7 Taf6 Brca1 Taf5 Taf4 Taf2 Mapk11 Taf1 Rad1 Csnk2a2 Tp53rkb Tp53rka Noc2l Csnk2a1 Hipk1 Rpa1 Csnk2b Rpa2 Stk11 Tp53 Ssrp1 Rpa3 Cdk2 Mre11 Kat5 Nbn Hus1 Atrip Tpx2 Dna2 Blm Chek1 Chek2 Nuak1 Rad9a Rad9b Bard1 Top3a Rps27a Prkab2 Rad17 Prkab1 Uba52 Atm Atr Ccna1 Ccna2 Plk3 Cdk5r1 Aurkb Cdk5 Rmi2 Rmi1 Dyrk2 Taf9 Brip1 Prkaa1 Ubb Mdm4 Taf9b Ubc Exo1 Taf15 Taf11 Taf10 Rfc5 Taf13 Taf12 Rfc3 Rhno1 Mapk14 Rfc4 Wrn Prkag3 Rfc2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-RNO-77288.1 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Eci1 Decr1 Acadm HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%10231054 Homologous DNA Pairing and Strand Exchange Rad51b Rad50 Chek1 Bard1 Top3a Palb2 Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc3 Xrcc2 Atm Rmi2 Rmi1 Brip1 Mre11 Kat5 Exo1 Nbn Dna2 Wrn Rad51c Blm Rad51 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%10230886 CHD chromatin remodelers Snrpg Snrpb Chd4 Hdac2 Sf3a1 H2ac18 Sf3a2 Hdac1 Sf3a3 Mta1 Mta2 Sf3b1 Mta3 Mbd3 Snrpd1 Sf3b3 Sf3b4 Sf3b5 Mbd2 Chd3 Snrpd3 Hist1h2bq Gatad2a Ctnnb1 Gatad2b Wdr5 Snrpepl2 Skic8 Chd1 Chd2 Chd8 Ssrp1 Ctr9 Paf1 Leo1 H2aj Ube2i H3-3b Hist3h2ba H2bc18 Snrpn H2az2 Cherp H2bc6 Rbbp4 Phf5a Zfp592 H2bc4 Fam124b Hist1h4m Ctcf H2bc1 Smndc1 Cdk2ap1 Rbbp7 Nr2f2 Zmynd8 Ikzf3 Ikzf1 Chd5 Chd6 Hist1h2ai Chd7 U2surp Zfp827 Tcf19 Zfp532 Adnp Cbx1 Pwwp2a Mbd3l1 Mbd3l2 Nr2c2 Cbx3 Rbm17 Cdc73 Phf6 Ddx46 Snrpa1 Ddx42 Puf60 H2ab2 H2ac4 Sumo1 Snrpf Dhx15 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint Psmd8 Psmd2 Rps27a Fkbpl Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Hsp90aa1 Tp53 Psmb6 Psmb1 Psmb3 Psmb2 Mapre1 Ccnb2 Ccnb1 Plk1 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Gtse1 Psmc4 Psmc3 Hsp90ab1 Cdk1 Ccnb2-ps2 Psmd7 Psmd6 Psmb6l1 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 97%10230894 Mitochondrial translation termination Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Gadd45gip1 AC132020.1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Mt-cyb Mt-co3 Mt-co2 Mtrf1l Mt-atp8 Gfm2 Mrrf Mt-atp6 Mrps9 Mrps2 Mrps7 Mrps5 Mt-nd4l Dap3 Mrpl54 Mrpl55 Mt-co1 Mrpl58 Mrps30 Mt-nd5 Mrps31 Mrps33 Mt-nd4 Mrps34 Mt-nd6 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mt-nd1 Mrpl46 Mrpl48 Mtrf1 Mrpl49 Mrps21 Kgd4 Mrps22 Mt-nd3 Mrps23 Mrps24 Mrps25 Mt-nd2 Mrps26 Mrps27 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%10231650 Regulation of MITF-M-dependent genes involved in apoptosis Sin3a Hdac1 Mitf Hint1 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 97%10231766 tRNA modification in the nucleus and cytosol Qng1 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-RNO-5389840.1 Mitochondrial translation elongation Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Gadd45gip1 AC132020.1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Gfm1 Mrps9 Mrps2 Mrps7 Mrps5 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mrpl49 Mrps21 Kgd4 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%10229084 RIP-mediated NFkB activation via ZBP1 Chuk Nkiras2 Dhx9 Nfkbia Ikbkg Nfkbib Nkiras1 Myd88 Rela Ikbkb Nfkb2 Nfkb1 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling Stat5a Stat5b Jak3 Syk Shc1 Lck Il2 Il2ra Ptk2b Il2rb TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH Rpa1 Rpa2 Rps27a Rpa3 Rchy1 Polh Ubb Ubc Uba52 Rfc5 Nploc4 Vcp Rfc3 Sprtn Ufd1 Rfc4 Pcna Rfc1 Rfc2 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-RNO-8937144.1 Aryl hydrocarbon receptor signalling Ahrr Ptges3 Hsp90ab1 Arnt2 Arnt Ahr ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation Traf6 Map2k3 Ikbkg Nod2 Map3k7 Nod1 Tab3 Ube2n Tab2 Tab1 Map2k6 Mapk11 Ripk2 Mapkapk3 Mapk14 Mapkapk2 Irak2 Irak1 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%10230290 N-Glycan antennae elongation St8sia6 Mgat4c St3gal4 Mgat4a Mgat4b St8sia3 B4galt2 B4galt3 St8sia2 Mgat5 St6gal1 B4galt4 B4galt5 B4galt6 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%10228490 Sensing of DNA Double Strand Breaks Rad50 Kpna2 Kat5 Nbn Atm Mre11 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids Pon2 Alox5 Pon3 Ltc4s Pon1 Alox5ap BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Mecr Hadha Echs1 Acadm Hadhb Hadh INTERLEUKIN-38 SIGNALING%REACTOME%R-RNO-9007892.1 Interleukin-38 signaling Il1f10 Il1rl2 Mapk8 Il1rapl1 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-RNO-442729.1 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde Camk4 Calm3 Camkk1 Camkk2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975163.1 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation Traf6 Tlr4 Rps27a Map3k7 Tab3 Tab2 Ticam2 Tab1 Cd14 Ticam1 Ubb Ubc Uba52 Ly96 Irak2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels Kcnj15 Kcnj16 Kcnj3 Kcnj2 Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gabbr1 Gnb4 Gnb3 Gnb5 Gng11 Gabbr2 Gng12 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gng10-ps1 Kcnj10 Kcnj12 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%10231228 AURKA Activation by TPX2 Actr1a Tubg1 Dynll1 Akap9 Aurka Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tpx2 Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Csnk1d Cep192 Clasp1 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Cep43 Cep41 Ninl Ckap5 Tubb5 Hsp90aa1 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Pafah1b1 Nde1 Nedd1 Pcm1 Ssna1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-RNO-8849469.1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Akt1 Ubb Ubc Arap1 Dok1 Uba52 Rps27a Ptk6 Cbl REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity Prkag1 Rad50 Prkag2 Tbp Taf4b Pip4k2b Ppp2r1b Taf7l-ps1 Pip4k2c Ppp2r1a Pip4k2a Prmt5 Topbp1 Rbbp8 Taf8 Taf7 Taf6 Brca1 Taf5 Taf4 Mta2 Taf2 Mbd3 Mapkap1 Mapk11 Taf1 Brpf1 Rad1 Tp53rkb Csnk2a2 Tp53rka Csnk2a1 Kat6a Chd3 Brd7 Pdpk1 Gatad2a Gatad2b Rpa1 Csnk2b Rpa2 Tp53 Ssrp1 Rpa3 Cdk2 Ep300 Rffl Mtor Tpx2 Mlst8 Tp63 Banp Rbbp4 Ccng1 Rbbp7 Smyd2 Prkab2 Prkab1 Usp7 Ehmt1 Jmy Plk3 Pip4p1 Cdk5 Dyrk2 Mapkapk5 Aurka Chd4 Hdac2 L3mbtl1 Akt3 Daxx Hdac1 Akt2 Kmt5a Akt1 Noc2l Hipk1 Ppp1r13l Ppp1r13b Brpf3 Stk11 Phf20 Mre11 Kat5 Nbn Cdk1 Hus1 Atrip Dna2 Blm Rnf34 Chek1 Chek2 Nuak1 Usp2 Rad9a Rad9b Bard1 Top3a Rps27a Sgk1 Rad17 Ppp2cb Ppp2ca Uba52 Tp73 Ttc5 Atm Atr Pou4f1 Ccna1 Ccna2 Pou4f2 Cdk5r1 Aurkb Rmi2 Rmi1 Taf9 Brip1 Pml Meaf6 Map2k6 Prkaa1 Ubb Mdm4 Prr5 Zfp385a Taf9b Ubc Exo1 Taf15 Rictor Taf11 Taf10 Rfc5 Ing5 Taf13 Ing2 Taf12 Rfc3 Rhno1 Mapk14 Brd1 Rfc4 Wrn Prkag3 Rfc2 SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin Acvr2a Inhba Smad2 Mapk1 Smad3 Acvr2b Fst Mapk3 Inhbb Inha Tgfbr3 Acvr1c Acvr1b Smad4 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-RNO-170822.1 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup58 Nup37 Nup205 Pom121 Gckr Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Gck Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-RNO-68881.1 Mitotic Metaphase Anaphase Transition Fbxo5 Plk1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%10230604 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Scp2 Acot8 Acox1 Acsl1 Acaa1b Elovl2 Elovl3 Elovl5 Elovl1 Fads2 Abcd1 Hsd17b4 Fads1 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230198 HS-GAG biosynthesis Sdc4 Sdc3 Gpc1 Gpc3 Gpc2 Gpc4 Gpc6 Agrn Sdc1 Sdc2 Hs3st4 Hs3st1 Extl2 Hs3st2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Slc35d2 Ndst4 Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Gpc5 Ext2 Ext1 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade C1qa Cfh C3 Cfi C2 C4 C5 C9 Cd46 C1s Cfhr1 C1r Cpn1 Cpn2 Cd19 ENSRNOG00000069193 Cpb2 AABR07065813.1 C1qc ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 C5ar2 C5ar1 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Elane F2 Cd55 C3ar1 Cr2 Serping1 Cr1l Clu Cd81 C4b C1qb SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%10230508 Sulfide oxidation to sulfate Usf1 Suox Slc25a10 Ethe1 Sqor PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10228808 Platelet homeostasis Ppp2r1b Ppp2r1a Apob Ppp2r5b Ppp2r5a Ppp2r5e Fgr Pla2g4a Atp2a1 Atp2b1 Atp2b4 Atp2a3 Atp2b3 Atp2a2 Lrp8 Pafah2 P2rx7 P2rx6 P2rx5 P2rx4 Trpc7 P2rx3 P2rx2 P2rx1 Trpc3 Itpr3 Itpr2 Ppp2cb Slc8a1 Ppp2ca Calm3 Slc8a2 Slc8a3 Pde1b Pde1a Pecam1 Adam22 Ppp2r5d Pde10a Pde11a Nos3 Nos2 Prkg2 Pde5a Pde9a Ptgir Prkg1 Pde2a Nos1 Ptpn6 Irag1 Itpr1 Ptpn11 Mapk14 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-RNO-9701898.1 STAT3 nuclear events downstream of ALK signaling Hdac3 Hdac2 Stat3 Hdac1 Ep300 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229768 NCAM1 interactions St8sia4 St8sia2 Col4a1 Col4a2 Ncam1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%10230988 Phospholipase C-mediated cascade; FGFR3 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf5 Fgf8 Fgf9 Fgfr3 Fgf16 Fgf17 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-RNO-5693607.1 Processing of DNA double-strand break ends Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Uimc1 Rad1 Hist1h2bq Rpa1 Rpa2 Rpa3 Cdk2 Ppp4r2 Pias4 Mre11 Ube2i Kat5 Hist3h2ba Timeless Nbn Hus1 Atrip Dna2 Sirt6 Blm Chek1 H2bc6 Ube2v2 Rad9a Rad9b H2bc4 Bard1 Hist1h4m Top3a H2bc1 Ube2n Ppp4c Clspn Rad17 Atm Atr Ccna1 Ccna2 Tp53bp1 Rmi2 Rmi1 Brip1 Brcc3 Herc2 Rnf168 Exo1 ABRAXAS1 Sumo3 Rfc5 Rnf8 Rfc3 Rhno1 Rfc4 Wrn Nsd2 Rfc2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-RNO-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Pold3 Msh6 Rpa1 Msh2 Rpa2 Lig1 Pold1 Rpa3 Pms2 Mlh1 Pold4 Exo1 Pold2 Pcna GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) Pold3 Gtf2h5 Rad23b Ercc2 Nfrkb Ccnh Cops5 Ercc1 Ercc3 Ercc4 Cdk7 Ino80e Cetn2 Ino80d Tfpt Ino80c Pias3 Ino80b Actr5 Sumo2 Actr8 Ruvbl1 Polk Pole3 Pole2 Ino80 Pole4 Cops7a Cops7b Actg1 Actl6a Cops3 Cops4 Cops6 Rpa1 Rpa2 Rpa3 Cops2 Xpa Ddb2 Pole Ube2i Cops8 Chd1l Yy1 Xpc Rad23a Pias1 Rnf111 Ube2v2 Rps27a Ube2n Mcrs1 Uba52 Usp45 Ddb1 Cul4a Parp2 Pold1 Gps1 Parp1 Pold4 Cul4b Mnat1 Ubb Sumo1 Ubc Rbx1 Sumo3 Rfc5 Pold2 Rfc3 Gtf2h2 Rfc4 Gtf2h1 Pcna Rfc1 Rfc2 Gtf2h3 RAC3 GTPASE CYCLE%REACTOME%R-RNO-9013423.1 RAC3 GTPase cycle Git1 Nckap1 Wasf2 Wasf1 Ocrl Abi2 Cyba Abi1 Cybb Arhgdib Garre1 Cyfip1 Lbr Diaph3 Cdc42ep1 Pgrmc2 Cdc42 Dsg2 Arhgap21 Vav2 Mcam Ophn1 Rab7a Stbd1 Emd Arhgap32 Lamtor1 Pik3r1 Pak4 Pik3r2 Esyt1 Mpp7 Vrk2 Pak1 Srgap2 Slitrk5 Slitrk3 Snap23 Tfrc Arhgap17 Bcr Pak2 Arap3 Arap2 Rapgef1 Syde1 Arhgap26 Racgap1 Rac3 Arhgap6 Vamp3 Arhgap35 Depdc1b Abr Cav1 Dock10 Fermt2 Epha2 Prex1 Itgb1 Trio Arhgap5 Mcf2 Arhgap42 Arhgap1 Abl2 Slc1a5 Jag1 Nox3 Nox1 Swap70 Amigo2 Noxa1 Arhgap15 Ykt6 Baiap2l1 Ncf1 Ncf2 Ncf4 Brk1 Git2 Noxo1 Taok3 Baiap2 Tiam1 Lman1 Nckap1l TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 97%10228582 Transport of the SLBP Dependant Mature mRNA Slbp Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Ncbp2 Ncbp1 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nxf1 Eif4e Nup93 Nup50 Nup35 Alyref Nup54 Nup98 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%10230792 CASP8 activity is inhibited Traf2 Fadd Ripk1 Casp8 Tradd Fas Cflar Faslg Tnfsf10 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-RNO-500657.1 Presynaptic function of Kainate receptors Grik3 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp4f4 Cyp1b1 Cyp2c66 Cyp2u1 Cyp2c11 Cyp1a1 Cyp4f1 Cyp1a2 Cyp4f3 Cyp4f40 Cyp4a12 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 97%10228158 Polymerase switching Pold3 Prim2 Pold1 Prim1 Pold4 Pola2 Rfc5 Pola1 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-RNO-446652.1 Interleukin-1 family signaling Ager Nfkbia Hmgb1l2 Il1r2 Hmgb1l1 Nlrx1 Il1r1 Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Psma4 Psma3 Nlrc5 Psma6 Chuk Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Il36a Tbk1 Il1rn Tollip Il1f10 Gsdmd Il36g Ctsg Il1rap Il18 Il18r1 Il33 Nkiras1 App Il18bp Ikbkb Nkiras2 Mapk8 Traf6 Peli1 Il1rapl1 Ikbkg Il1a Map3k8 Rps27a Map3k7 Il1b Stat3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Sqstm1 Skp1 Map3k3 Uba52 Il36rn Fbxw11 Alpk1 Rela Peli2 Tifa Peli3 Irak4 Irak3 Btrc Tnip2 Myd88 S100b Il18rap Map2k6 Hmgb1-ps34 Ubb Il1rl2 Il1rl1 Ubc N4bp1 Rbx1 Casp8 Nfkbib Irak2 Psmb6l1 Irak1 Casp1 ALANINE METABOLISM%REACTOME%R-RNO-8964540.1 Alanine metabolism Gpt Gpt2 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing Snrpg Snrpb Snrnp200 Sf3b1 Snrnp25 Snrpd1 Sf3b3 Ybx1 Sf3b4 Ncbp2 Sf3b5 Ncbp1 Srsf1 Prpf6 Zmat5 Srsf7 Snrpd3 Srsf2 Snrnp35 Snrpepl2 Ddx42 Polr2c Polr2a Zcrb1 Prpf8 Polr2b Polr2g Polr2h Zrsr2 Polr2e Rnpc3 Snrnp40 Polr2f Eftud2 Polr2i Polr2j Snrnp48 Snrpf Pdcd7 Ddx23 Gtf2f2 Gtf2f1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 97%10228590 Formation of the Editosome Apobec4 Apobec2 Apobec3 A1cf Apobec1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 97%10230908 Physiological factors Npr2 Mme Corin Nppc Npr1 Nppa Ces1d REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA Slc6a1 Slc6a11 Slc6a13 Slc6a12 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 97%10228992 AMPK inhibits chREBP transcriptional activation activity Adipor2 Adipor1 Prkag2 Adipoq Prkab2 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 97%10229170 Autodegradation of Cdh1 by Cdh1:APC C Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 EICOSANOIDS%REACTOME DATABASE ID RELEASE 97%10228550 Eicosanoids Cyp4f39 Cyp8b1 Cyp4f1 Tbxas1 Cyp4a14 Cyp4f3 Cyp4f40 Ptgis Cyp4a12 Cyp4b1 Cyp4f4 Cyp4a10 Cyp4a2 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%10230968 Nuclear events mediated by NFE2L2 Psmd8 Psmd2 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Crebbp Psma1 Skp1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Nfe2l2 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Gsk3b Ep300 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Prdx1 Srxn1 Psmd7 Psmd6 Psmb6l1 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 97%10230454 Acyl chain remodelling of PG Lpgat1 Crls1 Pla2g4f Pla2g2d Pla2g2f Pla2g2a Pla2g4a Pla2g1b Pla2g4d Lpcat1 Pla2r1 Pla2g4b Pla2g12a Lpcat4 Pla2g10 Pla2g5 Pla2g3 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%10229534 Apoptotic cleavage of cellular proteins Add1 Plec Stk26 Stk24 Prkcq Fnta Pkp1 Prkcd Lmna Ocln Casp6 Lmnb1 Clspn Bmx Birc2 Dsp Cdh1 Dsg3 Tjp1 Acin1 Ctnnb1 Satb1 Bcap31 Tjp2 Dsg2 Dsg1 Rock1 Apc Ptk2 Sptan1 Casp8 Casp7 Gsn Gas2 Casp3 Vim Mapt Sh3glb2 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-RNO-3065678.1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Ube2i Sae1 Sumo1 Uba2 Rwdd2b ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229964 Adherens junctions interactions Ost4 Tmem258b Cbll1 Pvr H2ac18 Eps15 Ezh2 Psma4 Psma3 Angptl4 Psma6 Jup Psma5 Psma2 Psma1 Csnk2a2 Dad1 Ctnnd1 Csnk2a1 Psmd12 Psmd11 Suz12 Pcsk6 Hist1h2bq Rac1 Ctnnb1 Psmd14 Psmd13 Hace1 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Vav2 Eed Psmb3 Psmb2 Pomt1 H2aj Arhgap32 Pomt2 Src Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Sp1 Banp Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m Jak2 H2bc1 Rbbp7 Amot Psmd1 Arhgef4 Adrm1 Hist1h2ai Mogs Cdh15 Nectin1 Cdh9 Cdh8 Nectin4 Cdh7 Cdh6 Cdh3 Prkcsh Cadm3 Cdh24 Cadm2 Cadm1 Mtbp Pcsk7 Afdn Ang2 Fyn Cdh18 Cdh17 Cdh13 Cdh12 Cdh10 Ganab Tiam1 Farp2 Rnf19b Zeb2 Cdh11 Adam19 Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Cdh1 Ctnna1 Cdc42 Tyk2 Il6st Sec11c Canx Sec11a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Stat3 Nfkb1 Birc2 Uba52 Xiap Rela Furin Vcl Il6 Il6r Ctsb Cdh2 H2ab2 Nectin2 Ubb Ctsl H2ac4 Ubc Ctss Smarca4 Pip5k1c Rpn2 Rpn1 Ostc Psmb6l1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 97%10231022 Metallothioneins bind metals Mt2 Mt3 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-RNO-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Pold3 Pole3 Pole2 Pole4 Rpa1 Fen1 Rpa2 Lig1 Polb Parg Parp2 Pold1 Rpa3 Apex1 Parp1 Adprs Pold4 Pole Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-RNO-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Bckdha Dbt Dld Bckdhb COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%10228790 Coagulation pathway Itgb3 F3 F7 Smpd1 F12 Fgb Fga Fgg Sdc1 Itga2b Sdc2 Serpina10 Cd177 Kng1 App Ano6 Ano5 Thbd Sdc4 Sdc3 Gpc1 Gpc3 Gpc2 Gpc4 Gpc6 Agrn Klkb1 F2r Procr F13a1 F2 F8 Proc Serpina5 Serpinc1 Serpine2 Serpind1 F13b F10 Pf4 F11 Tfpi Gp5 Proz Gp9 F9 Gp1bb Pros1 Prtn3 Gp1ba Gpc5 Serping1 Serpine1 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-RNO-9758881.1 Uptake of dietary cobalamins into enterocytes Cubn Cblif Amn ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport Arfgap3 Copa Dynll1 Arfgap2 Dynll2 Arfgap1 Gorasp1 Copb2 Gria1 Rab1b Arf1 Copb1 Cope Dync1li2 Dync1li1 Napa Golgb1 Bet1l Gosr1 Cnih1 Gosr2 Lman1l Sec24d Sec24c Cnih3 Sec24b Cnih2 Sec24a Col7a1 Trappc9 Ppp6c Sar1b Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Csnk1d Serpina1 Rab1A Mcfd2 Folr1 Spta1 Bet1 Ins1 Scfd1 Ins2 Sptbn1 Sptb Sptbn2 Sptan1 Sptbn5 Sptbn4 Cog1 Cog2 Cog3 Cog4 Preb Cog5 Cog6 Cog7 Cog8 Lman1 Actr1a Lman2 Ank1 Dctn1 Tfg Dctn2 Tmem115 Dctn4 Sec23ip Sec16b Sec16a Trappc2l Ctsc Kdelr2 Kdelr3 Ppp6r3 Trappc10 Mia2 Mia3 Dync1h1 Tmed9 Ctsz Tgfa Kdelr1 Dync1i2 Dync1i1 Arf4 Arf3 Stx17 Tmed10 Sec13 Gbf1 Tmed2 Trappc6b Tmed3 Trappc6a Copg1 Copg2 Sec31b Areg Sec31a Tmed7 F8 Ankrd28 Tbc1d20 Copz2 Cd59 Cd55 Copz1 Arf5 Sec22a Golga2 Nsf Uso1 Napb Actr10 Stx5 Napg Ykt6 Sec23a Arcn1 Lman2l AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) Rtn4 Arhgdia Omg Mag Ngfr Mcf2 Rhoa BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-RNO-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors LOC120093819 Hpx Cd163 Hmgb1l2 Sparc Stab1 Msr1 Hmgb1l1 Apol7al1 Apol9a Hba1 Hbb ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 Apoe ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 Apob ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Calr ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Hsp90b1 Cd36 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 Prdx1 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 Lrp1 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Jchain S100a9 Apoa1 Alb Hmgb1-ps34 Ambp Apol2 Apol7bl1 Scarb1 Hp BIOSYNTHESIS OF PROTECTINS%REACTOME DATABASE ID RELEASE 97%10231436 Biosynthesis of protectins Lta4h Alox15 Cyp1a1 Cyp1a2 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%10230854 Selective autophagy Tbk1 Dynll1 Dynll2 Ulk1 Ube2d2 Csnk2a2 Optn Dync1li2 Csnk2a1 Dync1li1 Csnk2b Dync1h1 Src Pcnt Map1lc3a Fundc1 Pgam5 Pink1 Dync1i2 Tomm7 Atg5 Tomm40 Atg12 Tomm22 Tomm20 Vdac2 Vdac3 Dync1i1 Vdac1 Tomm70 Ube2d3 Atg9a Usp30 Mterf3 Prkn Rps27a Ube2l3 Nbr1 Park7 Ube2n Pex5 Sqstm1 Map1lc3b Uba52 Atm Mfn1 Mfn2 Ubb Cftr Ubc Arl13b SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%10230748 SUMOylation of transcription cofactors Npm1 Safb Zfp131 Ddx17 Mbd1 Ctbp1 Casp8ap2 Park7 Uhrf2 Daxx Pias3 Sumo2 Mrtfa Ring1 Phc2 Phc1 Cbx4 Cbx2 Phc3 Sin3a Nrip1 Bmi1 Pcgf2 Rnf2 Ep300 Pias4 Trim28 Ube2i Pias2 Sumo1 Sumo3 Ing2 Pias1 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-RNO-399710.1 Activation of AMPA receptors Gria1 Gria4 Gria3 Gria2 NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism Rnls Naprt Nampt Slc22a13 Naxd Naxe Nmnat3 Nmnat2 Qprt Nadk2 Nt5e Slc25a51 Nudt12 Nmrk1 Slc5a8 Bst1 Cd38 Nadsyn1 Nadk Nmnat1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 97%10228422 RNA Polymerase II Pre-transcription Events Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Taf4b Taf7l-ps1 Gtf2a1 Eloa Cdk7 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Supt6h Taf5 Taf4 Nelfa Gtf2e1 Nelfb Cdk9 Taf2 Nelfe Taf1 Ctdp1 Gtf2e2 Ncbp2 Eloc Ncbp1 Elob Supt4h1 Nelfcd Mllt3 Skic8 Mllt1 Ssrp1 Ctr9 Paf1 Leo1 Ccnk Eaf1 Eaf2 Ccnt2 Eloa2l Tcea1 Cdc73 Polr2c Polr2a Taf9 Aff4 Polr2b Polr2g Polr2h Polr2e Iws1 Polr2f Mnat1 Polr2i Taf9b Polr2j Taf15 Taf11 Ell Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-RNO-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) Srebf1 Kpnb1 Ran Scap Mbtps1 Srebf2 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ppp2r1a Ncbp2 Ncbp1 Ppp2r2a Pabpc1 Rnps1 Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Magoh Rpl39 Rpl8 Rps11 Upf3b Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Dcp1a Eif4a3 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 Rbm8a LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Upf3a Rps25 Gspt2 Rps26 Gspt1 Rps27 Rps28 Smg1 Rps29 Smg9 Smg8 Smg7 Rpl27a Smg6 Rpl31l15 Smg5 Rps20 Upf1 Upf2 Rps21 Etf1 Pnrc2 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Casc3 Magohb Rpl15 Rpl17 Rpl18 Rpl19 Ppp2ca Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-RNO-174113.1 SCF-beta-TrCP mediated degradation of Emi1 Psmd8 Psmd2 Fbxo5 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Psmd12 Psmd11 Cdc20 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Fzr1 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins Ngf Pcsk5 Furin Pcsk6 HDL REMODELING%REACTOME%R-RNO-8964058.1 HDL remodeling Apoc2 Lcat Lipg Apoc3 Apoe Apoa1 Alb Pltp SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230826 SUMOylation of chromatin organization proteins Nup58 Nup37 Nup205 Pom121 Hdac2 Nup107 Nup188 L3mbtl2 Hdac1 Tpr Nup160 Sumo2 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Satb2 Aaas Suz12 Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Ube2i Pias2 Pias1 Hist1h4m Sec13 Hdac4 Ring1 Phc2 Phc1 Cbx4 Satb1 Cbx2 Phc3 Bmi1 Pcgf2 Rnf2 Sumo1 Sumo3 Nup93 Nup50 Nup35 Nup54 Nup98 UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 97%10230208 Ub-specific processing proteases Nfkbia Cdc25a Mat2b Usp14 H2ac18 Rce1 Usp18 ENSRNOG00000067432 Tab1 Psma4 Psma3 Hif1a Psma6 Ruvbl1 Psma5 Psma2 Psma1 Stam2 Rnf123 Psmd12 Ide Psmd11 Becn1 Psmd14 Psmd13 Siah2 Psmb5 Keap1 Foxo4 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Axin1 Psmb3 Psmb2 Psma7 Psmc5 Arrb1 Psmc2 Psmc1 Psmc4 Psmc3 Tomm20 Smad1 Vdac2 Vdac3 Suds3 Vdac1 Smad4 Psmd7 Tomm70 Psmd6 Usp30 Psmd8 Psmd2 Smad2 Smurf2 Smad3 Usp9x Smad7 Psmd1 Adrm1 Kat2a Usp8 Hist1h2ai Ripk1 Usp7 Arrb2 Ufd1 Ar Cftr Rig1 Usp13 H2ac25 Skp2 Tnks2 Axin2 Tgfbr1 Atxn7 Usp3 Mul1 Usp5 Rnf128 Rnf146 Tada2b Otub1 Wdr48 Tnks Usp44 Usp42 Usp48 Usp47 Ifih1 Usp34 Fkbp8 Usp33 Ccp110 Usp37 Usp22 Usp20 Usp26 Usp25 Usp24 Ddb2 Wdr20 Usp29 Il33 Usp28 Usp12 Usp11 Usp10 Usp16 Usp15 Usp19 Usp21 Snx3 Traf6 Usp2 Usp4 Ikbkg Tada3 Cyld Rps27a Map3k7 Clspn Traf2 Birc2 Uba52 Cdc20 Ccna1 Ccna2 Polb Adrb2 Pten Myc Ubb Mdm4 H2ac4 Taf9b Ubc Hgs Taf10 Gata3 Psmb6l1 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-RNO-5423646.1 Aflatoxin activation and detoxification Ggt1 Acy3 Dpep1 Dpep2 Cyp3a9 Cyp1a2 Acy1a Ggt5 Ggt7 Cyp2a2 Ggt6 Cyp3a18 Cyp3a1 Cyp2a1 Cyp3a62 Cyp3a2 Cyp2a3 Mgst3 Akr7a3 Mgst2 Akr7a2 Mgst1 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway Dera Tkt Shpk Rbks Pgd Prps1 Prps2 Prps1l3 G6pdx Pgm2 Taldo1 Rpe Rpia Pgls TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229020 TRIF (TICAM1)-mediated TLR4 signaling Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Irf3 Ube2d2 Tab2 Usp18 Tab1 Nlrc5 Cd14 Ikbke Chuk Mapk10 Mapk11 Ube2d3 Ube2d1 Tank Traf3 Sarm1 Ripk3 Fadd Ripk1 Tbk1 Optn Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Skp1 Birc2 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Rps6ka5 Rps6ka1 Tifa Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Ptpn11 Mapk14 Jun Mapkapk2 Irak2 Irak1 DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions Lat B2m Shc1 Klrk1 Rac1 Vav3 Plcg1 Plcg2 Pik3cb Btk Sirpa Vav2 Syk Pik3ca Siglec10 Trem2 Pik3r1 Trem1 Pik3r2 Lcp2 Tyrobp Nras Grb2 Fyn Kras Sos1 Hras Clec5a Siglec15 Klrd1 Klrc2 Klrc1 Lck Grap2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-RNO-109606.1 Intrinsic Pathway for Apoptosis Dynll1 Mapk8 Dynll2 Bcl2l1 Mapk1 Mapk3 Gsdme Ywhae Ppp3r1 Gsdmd Nmt1 Bax Diablol1 Bid Cycsl2 Casp9 Apaf1 Septin4 Xiap Ywhag Apip Gzmb Bak1 Bad Ppp3cc Ywhaq Ywhah Ywhab Pmaip1 Sfn Bmf Casp8 Ywhaz Casp7 Cycs Casp3 Bcl2l11 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) Pold3 Pole3 Pole2 Pole4 Xrcc1 Rpa1 Fen1 Rpa2 Lig1 Polb Parg Parp2 Pold1 Rpa3 Apex1 Parp1 Adprs Pold4 Mbd4 Smug1 Pole Mpg Tdg Nthl1 Ogg1 Ung Mutyh Rfc5 Pold2 Lig3 Rfc3 Rfc4 Neil2 Pcna Neil1 Rfc1 Pnkp Rfc2 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 97%10230234 Interferon alpha beta signaling Ifna4l1 Kpnb1 Ifna1l1 Rps27a Kpna1 Stat1 Ifnb1 Usp18 Socs1 Socs3 Ptpn1 Ifna4 Uba52 Ifna1 Irf9 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Tyk2 Ubb Ubc Ptpn6 Ptpn11 Rnasel ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-RNO-1300645.1 Acrosome Reaction and Sperm:Oocyte Membrane Binding Acr Izumo4 Cd9 Izumo3 Izumo2 Izumo1 CHROMOSOME MAINTENANCE%REACTOME%R-RNO-73886.1 Chromosome Maintenance Pold3 Cenpl Cenpk Cenpi Cenph Npm1 H2ac18 Ruvbl1 Pola2 Pola1 Hist1h2bq Chtf8 Terf2 Terf1 Tinf2 Rpa1 Chtf18 Rpa2 Ppp6r3 Ctc1 Stn1 Prim2 Tert Acd Terf2ip Rpa3 Ten1 Cdk2 Dscc1 Prim1 Pot1 H2aj Rsf1 Oip5 Hist3h2ba Mis18a Itgb3bp Cenpw Mis18bp1 Hjurp Dna2 Blm Ppp6c H2az2 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Hist1h2ai Ankrd28 Ccna1 Knl1 Ccna2 Shq1 Dkc1 Nhp2 Pif1 Fen1 Gar1 Lig1 Cenpc Wrap53 Cenpa Nop10 Rtel1 Pold1 Pold4 H2ab2 Smarca5 H2ac4 Cenpu Rfc5 Cenpt Pold2 Cenpq Rfc3 Cenpp Cenpo Rfc4 Wrn Cenpn Pcna Cenpm Rfc1 Rfc2 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-RNO-349425.1 Autodegradation of the E3 ubiquitin ligase COP1 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Atm Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Cop1 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229098 Interleukin-1 signaling Ager Nfkbia Hmgb1l2 Il1r2 Hmgb1l1 Nlrx1 Il1r1 Il1rn Usp14 Cul1 Tab3 Tab2 Usp18 Psma4 Tab1 Psma3 Tollip Nlrc5 Psma6 Chuk Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Il1rap Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Nkiras1 App Psmd7 Ikbkb Psmd6 Psmd8 Nkiras2 Psmd2 Traf6 Peli1 Ikbkg Il1a Map3k8 Rps27a Map3k7 Il1b Psmd1 Ube2n Adrm1 Lrrc14 Nfkb2 Nfkb1 Traf2 Sqstm1 Skp1 Map3k3 Uba52 Fbxw11 Alpk1 Rela Peli2 Tifa Peli3 Irak4 Irak3 Btrc Tnip2 Myd88 S100b Map2k6 Hmgb1-ps34 Ubb Ubc N4bp1 Rbx1 Casp8 Nfkbib Irak2 Psmb6l1 Irak1 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-RNO-9772755.1 Formation of WDR5-containing histone-modifying complexes Kansl1 Kansl2 Phf20l1 Setd1b Rbbp5 Bod1l1 Setd1a Pagr1 Tada3 Kmt2a Tada2a Kmt2c Kat2a Kmt2d Mcrs1 Zzz3 Kmt2b Sgf29 Psip1 Ogt Men1 Wdr5 Ash2l Tasp1 Akap8l Phf20 Cxxc1 Kat8 Paxip1 Yeats2 Kat2b Wdr82 Kat14 Mbip Hcfc1 Hcfc2 Dr1 Kansl3 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%10228832 Initiation of coagulation cascade F3 F7 F2 F10 F9 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%10230710 Ficolins bind to repetitive carbohydrate structures on the target cell surface Fcn2 Fcn1 Masp1 Masp2 G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 Lin37 Rbbp4 Rbl1 Cdk2 E2f4 E2f5 Hdac1 Rbl2 Lin9 Ccne1 Lin52 Ccne2 Lin54 Tfdp2 Ccna1 Dyrk1a Tfdp1 Ccna2 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 97%10231596 Azathioprine ADME Slc29a2 Hprt1 Nme1 Vav2 Abcc4 Abcc5 Vav1 Gsta6 Gsta3 Xdh Impdh2 Gsta1 Slc28a3 Gsta2 Slc28a2 Impdh1 Slc29a1 Tpmt Gmps Rac1 Nme2 Vav3 Gsta5 CHROMATIN ORGANIZATION%REACTOME%R-RNO-4839726.1 Chromatin organization Ccnd1 Cdk4 Kmt2a Kmt2c H2ac18 Ezh2 Mta1 Mta2 Mta3 Mbd3 Brpf1 Kat6a Chd3 Suz12 Gatad2a Hist1h2bq Gatad2b Ctnnb1 Wdr5 Ash2l Skic8 Chd1 Chd2 Eed Ssrp1 Ctr9 Paf1 H2aj H3-3b Hist3h2ba H2bc18 H2az2 H2bc6 Rbbp5 Rbbp4 H2bc4 Zfp592 Fam124b Hist1h4m Ctcf H2bc1 Cdk2ap1 Rbbp7 Nr2f2 Zmynd8 Ikzf3 Suv39h1 Ikzf1 Suv39h2 Smyd2 Chd5 Hist1h2ai Smyd3 Chd6 Setd3 Chd7 Zfp827 Nsd3 Tcf19 Setd2 Setd7 Zfp532 Adnp Kmt5c Setdb2 Cbx1 Hdac10 Setd6 Pwwp2a Nsd1 Mbd3l1 Aebp2 Mbd3l2 Mecom Hdac8 Prdm16 Kmt5b Cbx3 Prdm9 Dot1l Ash1l Ehmt1 Cdc73 Kdm4c Hdac2 Hdac1 Kmt5a Kdm1a Mbd2 Brpf3 Chd8 Leo1 Atf2 Padi2 Rcor1 Padi3 Padi4 Padi1 Kat7 Padi6 Ing4 Pax3 Hat1 Jade1 Jade2 Jade3 Kat6b Nfkb2 Msl2 Nfkb1 Msl3 Msl1 Nr2c2 Rela Rps2 Meaf6 Hmg20b Snrpf Snrpg Tbl1x Snrpb Prmt5 Kdm1b Ss18 Pbrm1 Smarcd1 Smarcb1 Smarcd3 Snrpd1 Smarcd2 Dpf1 Bicral Bicra Dpf2 Dpf3 Hdac3 Brd9 Brd7 Arid1a Snrpd3 Prmt1 Arid1b Ss18l1 Tbl1xr1 Bcl7a Bcl7b Bcl7c Actl6a Setdb1 Bcl11a Atf7ip Bcl11b Phf10 Snrpepl2 Smarce1 Wdr77 Smarcc1 Smarca2 Ncor2 Carm1 Gps2 Sap30l Suds3 Brms1 Rest Arid4b Arid4a Phf5a Smndc1 U2surp Snrpa1 Coprs H2ac25 Prmt6 Prmt7 Dhx15 Dnmt3a Prmt3 Actl6b Chd4 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 Actg1 Ncoa2 Phf20 Kat8 Ube2i Phf2 Riox2 Kdm2b Hcfc1 Kdm4d Kdm3b Snrpn Kdm5c Kdm3a Kdm5b Phf8 Kansl3 Cherp Kdm5a Kansl1 Kdm6b Kansl2 Kdm6a Kdm7a Setd1b Arid5b Setd1a Uty Jmjd6 Kmt2d Mcrs1 Kmt2b Ogt Brwd1 Rbm17 Phf6 Kdm4b Ddx46 Kdm4a Ddx42 Puf60 H2ab2 Sap18 H2ac4 Smarca4 Sumo1 Ing5 Brd1 Nsd2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Nek2l1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228328 Creatine metabolism Gamt Ckb Ckmt1 Ckmt2 Ckm Slc6a8 Slc6a11 Slc6a12 Gatm Slc6a7 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%10231258 Activation of the TFAP2 (AP-2) family of transcription factors Cited2 Cited4 Tfap2e Crebbp Tfap2c Tfap2a Wwox Tfap2b Cited1 Yeats4 Ep300 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 97%10228714 Response of endothelial cells to shear stress Pkn2 Itgb3 Nfkbia Ppp2r1b Ppp2r1a P2ry2 Ikbke Chuk Akt1 Mapkap1 Pdpk1 Adm Anxa2 Mtor Ppp2r2a Gng10-ps1 Mlst8 Ikbkb Gnas Ikbkg Calcrl Prkaca Prkacb Abl1 Stat1 Trpv4 Nfkb1 Ptpn1 Gna11 Prkar1a Prkar1b Ppp2ca Calm3 Gng3 Gng5 Rela Gng4 Itgb1 Gnaq Vcl Gng7 Pde4d Gng8 Gngt1 Prkar2a Gnb2 Yap1 Gnb1 Gnb4 Gnb3 Capn2 Gnb5 Ptk2 Gng11 Gng12 Nos3 Prr5 Capns1 Rictor Itgav Ramp2 NUCLEOTIDE METABOLISM%REACTOME%R-RNO-15869.1 Nucleotide metabolism Upp1 Upp2 Pudp Tk2 Uck1 Nudt9 Uck2 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Xdh Itpa Dnph1 Nt5c2 Nudt5 Txnrd1 Dguok Gmpr2 Pnp Upb1 Ampd3 Nt5c3a Ampd2 Dpys Dpyd Ampd1 Nt5m Gmpr Adk Hprt1 Dck Aprt Ada Dhodh Adsl Impdh2 Cad Rrm2b Impdh1 Gmps Txn Dtymk Adss2 Nudt13 Adss1 Dut Pfas Atic Rrm1 Umps Tyms Rrm2 Ppat Gart Ak1 Gsr Paics Nme3 Nme2 Ak2 Ak5 Glrx Ak4 Ak7 Ak6 Nme1 Ak9 Cmpk1 Dctd Ak8 Nme6 Entpd1 Ctps2 Entpd2 Ctps1 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 Samhd1 Tymp Cda REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%10229948 Reduction of cytosolic Ca++ levels Slc8a3 Atp2a1 Atp2b1 Atp2b4 Calm3 Slc8a1 Atp2a3 Atp2b3 Atp2a2 Slc8a2 Adam22 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%10229900 Thromboxane signalling through TP receptor Gng8 Gngt1 Aamp Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gna13 Gng12 Gna11 Gna14 Tbxa2r Gng3 Gng10-ps1 Gng5 Gng4 Gnaq Gng7 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-RNO-9855719.1 Regulation of FXIIa and plasma kallikrein activity F12 Hrg Klkb1 Serping1 A2m Krt1 Kng1 C1qbp Plaur CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin Aldh2 Slc6a4 Maoa REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity Mecp2 Sin3a Hdac2 Hdac1 Lbr SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230652 Scavenging by Class B Receptors Hmgb1-ps34 Hmgb1l2 Hmgb1l1 Cd36 Prdx1 S100a9 Apoa1 Apob Scarb1 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231414 RHOBTB2 GTPase cycle Msi2 Srrm1 Phip Hsp90aa1 Actb Stk38 Myo6 Cul3 Cct2 Txnl1 Cct7 Rhobtb2 Rbmx Hnrnpc Cdc37 Tmod3 Hsp90ab1 Cct6a Tra2b Ddx39b Actn1 Twf1 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-RNO-879518.1 Transport of organic anions Slco3a1 Slco4a1 Avp Slco2a1 Slco4c1 Slco1c1 SLC16A2 Slco1b2 Slco2b1 Slco1a4 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling Crebbp Maml1 Runx3 Kat2b Maml2 Kat2a Ep300 Maml3 Rbpj TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228324 Tryptophan catabolism Ido2 Ido1 Slc7a5 Kmo Aadat Tdo2 Kynu Kyat1 Haao Slc3a2 Slc36a4 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Fgf16 Fgf17 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%10228358 Metabolism of RNA Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Dcps Edc3 Edc4 Nt5c3b Psmb5 Patl1 Skic3 Psmb4 Skic2 Psmb7 Lsm3 Psmb6 Lsm5 Psmb1 Paip1 Dcp1b Psmb3 Lsm1 Psmb2 Pan2 Pan3 Lsm6 Lsm7 Ddx6 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ppp2r2a Psmd7 Psmd6 Psmd8 Psmd2 Rpl4 Rps14 Psmd1 Rps15 Rpl5 Adrm1 Rps16 Rpl3 Rps17 Rps18 Rps19 Las1l Ltv1 Rpl35 Fcf1 Rpl36 Rpsa Rpl37 Rpl38 Qng1 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rrp9 Rpl6 Rps13 Pwp2 Rpl7 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Imp4 Rpl27 Rpl28 Rpp25 Rpl29 Rpl12-ps1 Ncl Rpl22 Xrn2 Rpl23 Snu13 Wdr75 Senp3 Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rnf113a1 Rpl36l5 Rpl36l3 Rpl3l Upf3a Rps25 Gspt2 Rps26 Gspt1 Rps27 Smg1 Rps28 Smg9 Rps29 Pdcd11 Smg8 Pno1 Smg7 Rpl27a Smg6 Smg5 Rpl31l15 Upf1 Rps20 Upf2 Utp20 Etf1 Rps21 Nop14 Pnrc2 Rps23 Pelp1 Rps24 Rcl1 Utp25 Tbl3 Nol11 Rpp40 LOC100910714 Rps15a LOC102551819 Wdr3 Bud23 Dcaf13 Rps4x-ps13 Utp15 LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Rps3a Utp18 Wdr43 Rps27l Rrp7a Tnfsf13 Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Ddx49 Rpl35al8 Rps26-ps13 Wdr36 Rpl22l1 Ddx47 Rplp0 Rplp1 Rpl13a Rpl35al2 Rbbp6 Csnk1e Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Nol9 Mphosph6 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Anp32a Pes1 Parn Rpl11 Zcchc8 Bms1 Zfc3h1 C1d Rpl12 Yrdc Rps3 Zc3h18 Rps2 Zc3h4 Zc3h3 Rpl10a Exosc9 Ythdc2 Ythdc1 Rps4x Exosc8 Elavl1 Exosc5 Khsrp Krr1 Rbm26 Exosc4 Rbm27 Exosc7 Rbm7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Polr2c Exosc2 Polr2a Utp6 Nop58 Polr2b Nop56 Polr2g Bop1 Polr2h LOC134480579 Polr2e Polr2f Ebna1bp2 Mnat1 Wdr18 Tsr1 Polr2i Ddx21 Fau Polr2j Rpl23a Wdr12 Nup93 Nup50 Gemin6 Snrpf Gtf2h2 Gemin7 Gtf2h1 Nup35 Gtf2f2 Gtf2f1 Nup54 Nup98 Gtf2h3 Gemin5 Gtf2h5 Snrpg Snrpb Ercc2 Ccnh Nup58 Gemin8 Ercc3 Nup37 Nup205 Hspb1 Pom121 Cdk7 Prmt5 Nup107 Nup188 Tgs1 Tpr Smn1 Nup160 Snupn Rae1 Ndc1 Snrpd1 Nup85 Clns1a Nup42 Nup62 Nup43 Gemin7l1 Nup88 Aaas Xpo1 Snrpd3 Nup214 Ranbp2 Gemin2 Nup155 Nup133 Nup210 Nup153 Ddx20 Snrpepl2 Wdr77 Ppil2 Eif4e Eif4a2 Eif4a1 Pabpc1 Snrnp200 Phf5a Rnps1 Fam50a Smndc1 Gle1 Pnn Fyttd1 Znf830 Hnrnpr-ps2 Prpf40a Rnf113a2 U2surp Crnkl1 Ddx39a Cdc40 Aqr Pcbp2 Prcc Pcbp1 Ddx39b Magoh Sympk Clp1 Upf3b Sarnp Tfip11 Hnrnpr Dhx8 Dhx9 Wdr70 Hnrnpu Snrpa1 Hbs1l Rbm10 Mettl3 Steep1 Dhx38 Dhx35 C3h9orf78 Ptbp1 Mettl14 Sugp1 Ywhab Eif4a3 Zrsr2 Rnpc3 Hnrnpc Hnrnpd Hnrnpf Ppwd1 Hnrnpk Hnrnpl Pcf11 Cstf1 Gcfc2 Nudt21 Dhx16 Cstf2 Ccdc12 Dhx15 Cstf3 Slbp Srsf19 Srsf11 Srsf12 Srrm1 Rbm8a Sde2 Tut1 Slu7 Srrm2 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Ppp1cb Nkap Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Hnrnph2 Hnrnph1 Leng1 Prpf6 Mfap1al1 Zmat5 Cactin Ppig Ppie Thoc2 Thoc3 Thoc5 Hnrnpa2b1 Thoc6 Thoc7 Srrt Snrnp70 Rbmx2 Cwc22 Nsrp1 Cwc27 Cwc25 Zcrb1 Prpf8 Wbp11 Prpf19 Htatsf1 Prpf18 Snrnp40 Eftud2 Wdr82 Papolg Ppp1r8 Fip1l1 Snrnp48 Snip1 Papola Fam32a Snrpa Snrpc Snrpn Alyref Chtop Cwc15 Cherp Yju2 Fus Cpsf4 Cpsf6 Cpsf7 Rbm25l1 Cpsf1 Cpsf2 Gpatch1 Cpsf3 Casc3 Magohb Pqbp1 Isy1 Nxt1 Prr3 Cdc5l Snrnp25 Ybx1 Dnajc8 Rbm25 Srsf1 Plrg1 Rbm5 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Rbm22 Snrnp35 Hnrnpa3 Rbm17 Syf2 Ddx46 Bud31 Ddx41 Ddx42 Puf60 Wtap Cwf19l2 Poldip3 U2af1 Ppil4 Ramac Ppil3 Nxf1 Hnrnpa1 Ppil1 Sap18 Cstf2t Nxf5 U2af1l4 Nxf7 Tcerg1 Tra2b Pabpn1 Ywhaz Bud13 Bcas2 Pdcd7 Ddx23 Gpkow Rnmt Skic8 Hspa8 Apobec4 Apobec2 Apobec3 A1cf Apobec1 Dcp2 Dcp1a Zfp36l1 Xrn1 Akt1 Zfp36 Rngtt Tnpo1 Rps27a Rbmx Ppp2ca Uba52 Hspa1b Hspa1a Ctnnbl1 Ubb Ubc Mapkapk2 Ppp2r1a Adarb1 Adar Lsm10 Lsm11 Zfp473 Ncbp2 Ncbp1 Ppp1ca Prkcd Prkca Csnk1d Set Sec13 Acin1 Psmb6l1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-RNO-5656121.1 Translesion synthesis by POLI Rev1 Rpa1 Rpa2 Rps27a Rpa3 Rev3l Poli Ubb Ubc Uba52 Rfc5 Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 97%10228476 Formation of editosomes by ADAR proteins Adarb1 Adar OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-RNO-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA Dlst Dld Dhtkd1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231312 RUNX1 regulates estrogen receptor mediated transcription Cbfb Runx1 Esr1 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%10231220 MET activates PI3K AKT signaling Met Grb2 Gab1 Pik3ca Hgf Pik3r1 UREA CYCLE%REACTOME%R-RNO-70635.1 Urea cycle Nags Asl Slc25a15 Sirt5 Arg2 Cps1 Otc Arg1 Slc25a2 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-RNO-379397.1 Enzymatic degradation of dopamine by COMT Tomt Maoa Comt POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 97%10230000 Post-transcriptional silencing by small RNAs Ago3 Ago2 Ago1 Tnrc6c Tnrc6a Tnrc6b Ago4 NADE MODULATES DEATH SIGNALLING%REACTOME%R-RNO-205025.1 NADE modulates death signalling Bex3 Ywhae Casp2 Ngf Casp3 Ngfr PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%10228782 Platelet activation, signaling and aggregation P2ry12 Rhob Adra2a Adra2c Adra2b Arrb1 Egf Cd36 Tuba4a Kng1 Hgf Trpc7 Ptpn1 Trpc3 Itpr3 Itpr2 F2r F13a1 Arrb2 F2 F2rl2 F2rl3 Abcc4 Phactr2 Stxbp3 Apoa1 Ptk2 Alb Vti1b Chid1 Prkch Grb2 Fyn Cfd A1bg Gp6 Sos1 Serping1 Psap Pdgfa Pdgfb Clu Serpine1 Islr Pcyox1l Hrg Mgll Lhfpl2 Gas6 Sytl4 Ly6g6f Ahsg Spp2 P2ry1 Serpina3n Akt1 Timp3 Fn1 Apbb1ip Fam3c Fgb Mpig6b Fga Rap1b Dgka Serpinf2 Fgg Dgkb Itga2b Rapgef4 Abhd6 Rapgef3 Dgkd Rasgrp1 Dgke Rasgrp2 Dgkg Tln1 Anxa5 Qsox1 Brpf3 Lgals3bp Dgkh Dgki Dgkk Lamp2 Dgkq Dgkz Wdr1 Daglb Maged2 Endod1 Prkcb Serpina4 Dagla Habp4 Cdc37l1 Tagln2 App Itih4 Itih3 Nhlrc2 Fermt3 Mapk1 Lefty2 Thbs1 Manf Lefty1 Apoh Mapk3 Igf1 Gtpbp2 Orm1 Rab27b Ecm1 Ola1 Rac2 Ctsw Actn4 Tmsb4x Cd63 Tor4a Clec1b F8 Tmx3 Fcer1g Pdpn Scg3 Vcl Selp Cyrib Abhd12 Sccpdh Srgn Pecam1 Gp5 Gp9 Aplp2 Gp1bb Mmrn1 Pros1 Gp1ba Cd9 Plek Sod1 Mapk14 Itgb3 Bcar1 Prkcq Vegfa Vegfd Vegfc Vegfb Aldoa Rhog Pdpk1 Rac1 Vav3 Cyb5r1 Plcg2 Rap1a Vav2 Lyn Src Rhoa Lcp2 Pla2g4a Gng10-ps1 Prkce Lck Pik3r5 Pik3r6 Pik3cg Aamp Raf1 Lat Prkcg Prkcd Gnai2 Gnai1 Prkca Gna13 Gnai3 Serpina1 Gna11 Gna14 Calm3 Gng3 Actn1 Gng5 Gng4 Flna Gnaq Gng7 Gng8 Gngt1 Gnat3 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Actn2 Pcdh7 Csk Tbxa2r Ppbp Itpr1 Stxbp2 AABR07021573.2 Sparc Tgfb1 Tgfb2 Tgfb3 Cd109 Actg1 Cdc42 Syk Vav1 Tf Pik3r1 Pik3r2 Pik3r3 Stx4 Igf2 Plg Shc1 Pik3cb Timp1 Pik3ca Pf4 A2m Crk Ywhaz Ptpn6 Ptpn11 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-RNO-1663150.1 The activation of arylsulfatases Arsg Sumf1 Arsb Sumf2 Sts Arsa Arsl Arsk Arsj Arsi SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-RNO-9938024.1 Somatic hypermutation of immunoglobulin genes Pold3 Rev1 Msh6 Msh2 Mcm3ap Rps27a Pms2 Mlh1 Rev3l Apex2 Poli Polh Uba52 Ctnnbl1 Ubb Ubc Exo1 Aicda Rfc5 Pold2 Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME%R-RNO-9648025.1 EML4 and NUDC in mitotic spindle formation Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Nup160 Rps27 Nup85 Dync1li2 Clip1 Nup43 Dync1li1 Xpo1 Ranbp2 Ppp2r5b Ppp2r5a Kif18a Nup133 Ppp2r5e Dync1h1 Plk1 Itgb3bp Dync1i2 Dync1i1 Nudc Sec13 Eml4 Clasp1 Clasp2 Spc24 Ppp2cb Birc5 Ppp2ca Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ppp2r5d Ahctf1 Mapre1 Zwint B9d2 Pafah1b1 Ska2l1 Bub1 Zw10 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 97%10228600 RNA Polymerase III Transcription Initiation From Type 2 Promoter Polr3e Tbp Polr3b Brf1 Polr3c Polr3f Polr3g Gtf3c2 Polr3gl Gtf3c1 Crcp Gtf3c4 Bdp1 Gtf3c3 Gtf3c6 Gtf3c5 Polr2h Polr2e Polr2f Polr1c Polr3a Polr3d DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%10228196 DNA Damage Telomere Stress Induced Senescence Rad50 Hmga1 H2bc6 H2bc4 Hist1h4m H2bc1 Rb1 H2ac18 Lmnb1 Hist1h2ai Ccne1 Ccne2 Atm Hist1h2bq Ccna1 Ccna2 Terf2 Terf1 Tinf2 Tp53 Acd Terf2ip Cdk2 Pot1 H2aj H2ab2 Mre11 Hist3h2ba Kat5 H2ac4 Ep400 Nbn H1-1 H1-0 Asf1a H1-5 Cdkn1b Cabin1 H1-4 Hira H4f3 Ubn1 H2az2 Hmga2 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-RNO-399719.1 Trafficking of AMPA receptors Cacng8 Cacng4 Cacng2 Prkcg Cacng3 Ap2b1 Prkca Grip2 Gria1 Gria4 Camk2a Gria3 Gria2 Epb41l1 Pick1 Akap5 Dlg1 Myo6 Nsf Dlg4 Tspan7 Ap2a2 Ap2s1 Ap2a1 Prkcb Camk2g Camk2d Camk2b Ap2m1 Grip1 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-RNO-8932504.1 DAG1 core M2 glycosylations Mgat5b Dag1 Pomt1 Pomgnt1 Pomt2 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230268 Negative regulators of RIG-I MDA5 signaling Tbk1 Ubb Nlrx1 Ubc Mavs Uba52 Tax1bp1 Cyld Rps27a Irf3 Rig1 Ikbke CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-RNO-9943965.1 CHD3, CHD4, CHD5 subfamily H2bc6 Rbbp4 Zfp592 H2bc4 Hist1h4m H2bc1 Cdk2ap1 Rbbp7 Chd4 Hdac2 Nr2f2 Zmynd8 H2ac18 Ikzf3 Hdac1 Ikzf1 Chd5 Hist1h2ai Mta1 Mta2 Zfp827 Tcf19 Mta3 Zfp532 Mbd3 Adnp Cbx1 Pwwp2a Mbd3l1 Mbd2 Mbd3l2 Nr2c2 Chd3 Cbx3 Hist1h2bq Gatad2a Gatad2b Phf6 H2aj H2ab2 Ube2i H3-3b Hist3h2ba Sumo1 H2ac4 H2bc18 H2az2 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling Fadd Casp8 Cflar Tnfsf10 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 97%10231186 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Csnk2b Gnb2 Pdcl Gnb1 Cct6b Cct3 Gnb4 Rgs7 Gnb3 Cct2 Gnb5 Cct7 Rgs9 Tcp1 Csnk2a2 Cct8 Cct6a Csnk2a1 Cct5 Cct4 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME DATABASE ID RELEASE 97%10229564 C-type lectin receptors (CLRs) Nfkbia Cul1 Tab3 Ube2d2 Tab2 Tab1 Psma4 Psma3 Psma6 Chuk Psma5 Pycard Crebbp Psma2 Psma1 Cdc34 Nfatc3 Psmd12 Nfatc2 Psmd11 Pdpk1 Psmd14 Psmd13 Psmb5 Plcg2 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Lyn Ep300 Src Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Pak1 Psmc3 Psmd7 Pak2 Psmd6 Psmd8 Ube2d1 Psmd2 Raf1 Prkaca Prkacb Prkcd Psmd1 Adrm1 Ube2m Calm3 Nras Fyn Kras Hras Uba3 Pak3 Syk Ikbkb Traf6 Ikbkg Ppp3ca Rps27a Map3k7 Il1b Ppp3cb Ube2n Bcl10 Nfkb2 Nfkb1 Nfatc1 Ppp3r1 Skp1 Uba52 Fbxw11 Rela Fcer1g Cd209a Map3k14 Rps6ka5 Malt1 Btrc Relb Clec7a Clec4d Clec4e Card9 Clec6a-ps1 Ubb Ubc Icam2 Casp8 Psmb6l1 NGF-STIMULATED TRANSCRIPTION%REACTOME%R-RNO-9031628.1 NGF-stimulated transcription Srf Nab2 Chd4 Egr2 Sgk1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Cdc25c Chek2 Ywhaq Ywhah Ywhab Ccnb1 Sfn Ywhae Wee1 Cdk1 Ywhag Ywhaz Ccna1 Ccna2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Mapk8 Traf6 Ikbkg Nod2 Map3k7 Nod1 Tab3 Ube2n Tab2 Map2k7 Tab1 Mapk10 Ripk2 Mapk9 Irak2 Irak1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%10229434 Beta-catenin phosphorylation cascade Amer1 Ppp2r1b Csnk1a1 Ppp2r1a Ppp2r5e Apc Axin1 Ppp2r5d Gsk3b Frat2 Frat1 Ppp2cb Ppp2ca Ctnnb1 Ppp2r5b Ppp2r5a CELL CYCLE, MITOTIC%REACTOME%R-RNO-69278.1 Cell Cycle, Mitotic Cenpl Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ccnd1 Ndc80 Cdk4 Gorasp1 H2ac18 Psma4 Psma3 Ajuba Psma6 Psma5 Ywhae Psma2 Psma1 Csnk2a2 Csnk2a1 Ywhag Chmp3 Psmd12 Psmd11 Hist1h2bq Chmp7 Psmd14 Psmd13 Ppp2r5b Ppp2r5a Chmp6 Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Ppp2r5e Kif20a Psmb3 Psmb2 H2aj Psma7 Psmc5 Hist3h2ba Psmc2 Tubal3 Psmc1 Rcc1 Psmc4 Spast Psmc3 Espl1 Ppp2r2a Tuba4a Tuba3b Ptk6 Tubb4b Tubb4a Nek2l1 Tuba1a Tfdp2 Psmd7 Tuba1c Tfdp1 Psmd6 Cc2d1b Tubb2b H2az2 Psmd8 Tubb2a Psmd2 Ist1 Ube2d1 H2bc6 Sirt2 Tuba8 Tubb6 Rbbp4 Tubb3 H2bc4 Tubb1 Hist1h4m H2bc1 Ran Rbl1 E2f4 Psmd1 E2f5 Adrm1 Hist1h2ai Hdac8 Ofd1 Fbxl7 Hdac1 Rps27 Kmt5a Csnk1e Hsp90aa1 Mnat1 Hsp90ab1 Nup93 Nup50 Nup35 Nup54 Nup98 Ccnh Nup58 Nup37 Nup205 Pom121 Cdk7 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Xpo1 Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Tp53 Lyn Src Cdkn1b Jak2 Skp2 Aurka Fbxo5 Cdc14a Rb1 Pttg1 Ppp1cb Clip1 Ncapd2 Ncapg Smc4 Ncaph Smc2 Gins2 Gins1 Gins4 Gins3 Cdc25c Cdc25a Lmna Lmnb1 Tpx2 Ppp1r12b Ppp1r12a Cpap Cdkn2b Cdkn2d Actr1a Dctn1 Dctn2 Akt3 Akt2 Akt1 Optn Cnep1r1 Ctdnep1 Emd Ccnb2 Nek9 Ccnb1 Plk1 Lpin3 Lpin2 Vrk1 Vrk2 Prkcb Banf1 Cdk1 Ccnb2-ps2 Mapk1 Rps27a Nudc Mapk3 Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Ube2s Ccnd2 Ccne1 Ccne2 Ube2c Ccnd3 Cdc27 Cdc26 Cdc23 Cks1b Anapc10 Anapc16 Cdk6 Anapc15 Anapc5 Anapc4 Anapc1 Golga2 Anapc2 Fzr1 Btrc Anapc7 Ube2e1 Cdc16 Ppp2r5d Pkmyt1 Chmp4bl1 Ubb Ubc Gtse1 Wee1 Rfc5 Pold2 Rfc3 Cenpe Rfc4 Pcna Rfc1 Chmp2a Rfc2 Pold3 Chmp2b Kpnb1 Ppp2r1b Ppp2r1a Cul1 Rab1b Pole3 Pole2 Mcm7 Dync1li2 Mcm8 Pola2 Pola1 Dync1li1 Pole4 Dbf4 Orc5 Orc4 Orc6 Lbr Orc1 Orc3 Orc2 Cdt1 Gmnn Rpa1 Rpa2 Cdc7 Cdc6 Prim2 Rpa3 Cdk2 Prim1 Mcm3 Mcm4 Mcm5 Mcm10 Pole Mcm2 Ankle2 Itgb3bp Pcnt Prkaca Vps4a Prkca Csnk1d Cep192 Eml4 Tubgcp2 Set Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Lin52 Rab1A Lin54 Cep63 Chmp4c Alms1 Mzt1 Mzt2 Cep43 Phlda1 Cep41 Lin37 Tuba1b Ninl Rab2a Numa1 Tubb5 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Haus1 Tubgcp6 Tubgcp5 Esco1 Tubgcp4 Pafah1b1 Cdca5 Tubgcp3 Esco2 E2f1 Zw10 E2f2 Pds5b E2f3 Stag2 Cdk11b Stag1 Nedd1 Pds5a Smc1a Ppp2r3b Smc3 Blzf1 Lcmt1 Wapl Ncaph2 Nipbl Obi1 Foxm1 Mau2 Pcm1 Dyrk1a Ssna1 Tubg2 Tubg1 Cables1 Arpp19 Akap9 Cdc25b Ncapd3 Nme7 Sfi1 Ncapg2 Fkbpl Cetn2 Cdkn1c Bora Cep250 Gorasp2 Cep135 Cep131 Cdk5rap2 Mastl Mcph1 Rbl2 Cep152 Lin9 Cep290 Cep164 Ppme1 Ticrr Kif18a Ccp110 Dync1h1 Ube2i Mis18bp1 Hjurp Dync1i2 Dna2 Dync1i1 Phf8 Kif23 Abl1 Sec13 Firrm Clasp1 Clasp2 Spc24 Birc5 Spc25 Rab8a Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Ccna1 Mad2l1 Ccna2 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Fen1 Aurkb Cenpc Lig1 Cenpa Spdl1 Pmf1 Pold1 Ska2 Ska1 Ahctf1 Mapre1 Pold4 Zwint B9d2 Ska2l1 H2ab2 Bub1 Ppp1cc Taok1 Nde1 Sumo1 Rcc2 H2ac4 Kntc1 Rbx1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Cenpq Kif2c Cenpp Cenpo Cenpn Cenpm Mis12 Psmb6l1 Zwilch ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-RNO-442380.1 Zinc influx into cells by the SLC39 gene family Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc39a8 Slc39a7 Slc39a14 Slc39a6 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-RNO-186712.1 Regulation of beta-cell development Akt1 Foxo1 Akt3 Akt2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 97%10228368 Formation of the ternary complex, and subsequently, the 43S complex Rps25 Rps26 Rps27 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Rps15a Rps4x-ps13 Rps3a Rps27l Eif1ax Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Rps14 Eif3h Rps15 Eif3g Eif3b Rps16 Eif3a Eif3d Rps17 Eif3c Rps18 Rps19 Rpsa Uba52 Rps10 Rps11 Rps3 Rps2 Rps13 Rps4x Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Fau CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10229748 Cell-cell junction organization Ost4 Tmem258b Cbll1 Pvr H2ac18 Eps15 Ezh2 Psma4 Psma3 Angptl4 Psma6 Jup Psma5 Psma2 Psma1 Csnk2a2 Dad1 Ctnnd1 Csnk2a1 Psmd12 Psmd11 Suz12 Pcsk6 Hist1h2bq Rac1 Ctnnb1 Psmd14 Psmd13 Hace1 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Vav2 Eed Psmb3 Psmb2 Pomt1 H2aj Arhgap32 Prkci Pomt2 Src Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Sp1 Banp Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m Jak2 H2bc1 Rbbp7 Amot Psmd1 Arhgef4 Adrm1 Hist1h2ai Pard6b Mogs Cdh15 Nectin1 Cdh9 Cdh8 Nectin4 Cdh7 Cdh6 Cdh3 Prkcsh Cadm3 Cdh24 Cadm2 Cadm1 Mtbp Pcsk7 Afdn Ang2 Fyn Cdh18 Cdh17 Cdh13 Cdh12 Cdh10 Ganab Tiam1 Farp2 Rnf19b Zeb2 Cdh11 Adam19 Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Cdh1 Ctnna1 Cdc42 Tyk2 Il6st Sec11c Canx Sec11a Pard6a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Stat3 Nfkb1 Birc2 Pard3 Pard6g Uba52 F11r Xiap Rela Furin Vcl Il6 Il6r Ctsb Cdh2 H2ab2 Nectin2 Sdk1 Ubb Sdk2 Ctsl H2ac4 Ubc Ctss Smarca4 Pip5k1c Rpn2 Rpn1 Ostc Psmb6l1 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231410 RHOBTB1 GTPase cycle Cops4 Srrm1 Spen Rbbp6 Cpsf7 Rock2 Rock1 Stk38 Gps1 Cops2 Myo6 Cul3 Cct2 Txnl1 Cct7 Rbmx Hnrnpc Rhobtb1 Pde5a Rnf20 Tra2b Vim SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-RNO-9958517.1 SLC-mediated bile acid transport Slc44a5 Slc5a7 Slc10a6 Slc44a1 Slc44a2 Slc44a3 Slc44a4 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%10231782 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ube2d2 Psma4 Psma3 Psma6 Psma5 Psma2 Cul2 Psma1 Eloc Elob Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rpl4 Psmd1 Rpl5 Adrm1 Rpl3 Rpl35 Rpl36 Rpl37 Rpl38 Rpl39 Rpl8 Rpl9 Rpl6 Ltn1 Rpl7 Nemf Rpl30 LOC134486107 Klhdc10 Rpl31 Tcf25 Rpl32 Rchy1 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 LOC100910714 LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rps27a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rpl10a LOC134480579 Ubb Ubc Rbx1 Rpl23a Psmb6l1 G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition Cdc25c Dynll1 Cdc25a Ccnh Ppp2r1b Ppp2r1a Cdk7 Cul1 Psma4 Ajuba Psma3 Psma6 Psma5 Ywhae Psma2 Psma1 Ywhag Psmd12 Psmd11 Xpo1 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Cdk2 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Pcnt Psmc1 Psmc4 Psmc3 Ppp2r2a Tpx2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Psmd7 Psmd6 Psmd8 Psmd2 Prkaca Psmd1 Adrm1 Csnk1d Cep192 Tubgcp2 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Mzt1 Mzt2 Phlda1 Cep43 Cep41 Ninl Tubb5 Odf2 Ppp1r12b Haus7 Haus8 Haus4 Ppp1r12a Haus5 Haus6 Cpap Ofd1 Haus1 Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Tubgcp3 Cdk11b Nedd1 Ppp2r3b Lcmt1 Obi1 Foxm1 Pcm1 Ssna1 Tubg2 Actr1a Tubg1 Cdc25b Akap9 Nme7 Aurka Sfi1 Fkbpl Dctn1 Cetn2 Dctn2 Bora Fbxl7 Cep250 Cep135 Ppp1cb Cep131 Cdk5rap2 Cep152 Optn Cep290 Cep164 Ppme1 Ticrr Ccp110 Dync1h1 Ccnb2 Ccnb1 Plk1 Mis18bp1 Hjurp Cdk1 Ccnb2-ps2 Dync1i2 Csnk1e Rps27a Clasp1 Skp1 Ppp2cb Ppp2ca Uba52 Rab8a Fbxw11 Ccna1 Ccna2 Sgo1 Ckap5 Hsp90aa1 Btrc Fzr1 Mapre1 Pkmyt1 Ubb Mnat1 Nde1 Ubc Gtse1 Wee1 Hsp90ab1 Rbx1 Psmb6l1 SMAC (DIABLO) BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC (DIABLO) binds to IAPs Diablol1 Xiap Casp7 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006934.1 Signaling by Receptor Tyrosine Kinases Nedd4 Stam2 Kl Gab1 Atp6v0b Fgf10 Flt3 Fgf3 Trib3 Fgf22 Ide Fgf7 Atp6v0a4 Grb10 Ctnnb1 Pik3c3 Atp6v1g3 Atp6v0e2 Atp6v0a1 Epn1 Atp6v1c2 Atp6v1c1 Atp6v0c Ptprf Them4 Pde3b Pik3r4 Atp6ap1 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Fgfr3 Egf Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Ptk6 Hgf Lrig1 Ptpn2 Usp8 Ptpn1 Met Braf Mknk1 Rnf41 Col4a1 Col4a2 Ptk2 Nras Grb2 Fyn Kras Sos1 Hras Pdgfa Pdgfb Hdac2 Hdac1 Cul5 Ntrk1 Ngf Megf11 Lama4 Tns4 Tns3 Sh2b2 Thbs1 Igf1 Sgk1 Hsp90aa1 Plat Wwp1 Polr2c Polr2a Polr2b Polr2g Shc3 Nrp1 Polr2h Flt1 Polr2e Nrp2 Polr2f Prr5 Ncf1 Polr2i Pdgfc Ncf2 Pdgfd Flt4 Polr2j Cilp Ncf4 Rictor Tnk2 Alk Brk1 Itgav Mdk Shb Mst1r Kdr Thbs2 Thbs4 Baiap2 Nck1 Grap Gtf2f2 Ptk7 Gtf2f1 Sh2d2a Nckap1l Ptpru Pgf Mst1 Itgb3 Ptn Shc2 Alkal2 Bcar1 Alkal1 Nckap1 Fer Elmo2 Ltk Elmo1 Ptpn18 Hspb1 Vegfa Vegfd Vegfc Vegfb Prkcz Mapk12 Wasf3 Mapk13 Esr1 Wasf2 Wasf1 Jup Mapkap1 Axl Abi2 Cyba Ctnnd1 Igf1r Abi1 Hdac3 Cybb Cyfip2 Cyfip1 Pdpk1 Map2k1 Ntf3 Ralgds Rap1a Galnt3 Ntf4 Ntrk2 Kit Bdnf Sphk1 Lyn Ep300 Yes1 Src Itga3 Rhoa Kitlg Mtor Map2k2 Mlst8 Prkce Lck Jak2 Ntrk3 Fes Ptbp1 Ywhab Nos3 Hnrnpf Crkl Stat5a Stat5b Hnrnph1 Ctnna1 Stat6 Jak3 Gab2 Vav1 Pik3r1 Pik3r2 Pik3r3 Igf2 Rapgef1 Stat3 Stat1 Irs1 Irs2 Plg Spp1 Shc1 Furin Cma1 Pik3cb Pik3ca Ptprz1 Hnrnpa1 Crk Ptpn6 Cbl Ptpn11 Ptk2b Tec Fgfrl1 Spred1 Spred2 Clta Cltc Pcsk5 Pcsk6 Sh3gl2 Wwox Ranbp9 Ranbp10 Itga2 Hgfac Hpn Rab4b Gga3 Spint2 Spint1 Akt3 Akt2 Akt1 Rap1b Erbb2 Cdc37 Flrt1 Flrt3 Prkcb Flrt2 Diaph1 Erbb3 Nrg2 Nrg1 Nrg3 Memo1 Itch Atf1 Mapk7 Mapk1 Hbegf Rps27a Mapk3 Ppp2cb Areg Ppp2ca Uba52 Cav1 Fam83b Frs2 Vrk3 Frs3 Kidins220 Rps6ka3 Grb7 Rps6ka5 Arf6 Rps6ka1 Rps6ka2 Yap1 Ctsd Ppp2r5d Dusp3 Dusp4 Ubb Ap2s1 Ubc Eps15l1 Dusp7 Dusp6 Mapkapk3 Mapk14 Mapkapk2 Ppp2r1b Ppp2r1a Eps15 Egfr Mapk11 Ncbp2 Ncbp1 Rab4a Rac1 Vav3 Plcg1 Dock3 Vav2 Fgfbp3 Fgfbp1 Pak1 Ap2m1 Sh3gl3 Pxn Ptpn3 Pak2 Ptpn12 Grap2 Pag1 Fam83a Sh3kbp1 Spry2 Dock7 Spry1 Fam83d Aamp Prkaca Prkacb Prkcd Pdgfrb Pdgfra Sh3gl1 Prkca Calm3 Itgb1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Ins1 Fgf5 Fgf8 Fgf9 Ins2 Klb Fgf19 Fgfr4 Ereg Tlr9 Srf Csk Tgfbr3 Gipc1 Fgfr1 Nck2 Mmp9 Nab2 Btc Dnal4 Chd4 Egr2 Psenen Psen1 Stam Psen2 Ncstn Aph1a Arhgef7 Aph1b Rasa1 Pak3 Rbfox2 Cdc42 Esrp2 Esrp1 Tial1 Tia1 Rock2 Rock1 Tgfa Chek1 Ap2b1 Stub1 Ap2a2 Ap2a1 Hgs ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%10230058 Ion influx efflux at host-pathogen interface Atp7a Atox1 Slc11a1 NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions Sdcbp Ank1 Nfasc GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228518 Glycerophospholipid biosynthesis Slc44a1 Lpgat1 Slc44a2 Pitpnb Liph Lipi Mfsd2a Csnk2a2 Csnk2a1 Gpat4 Gpat3 Pnpla3 Csnk2b Pnpla2 Tafazzin Agk Pld1 Pcyt1b Pcyt1a Abhd3 Cds2 Gnpat Pla2g4a Pgp Awat2 Acp6 Crls1 Ddhd2 Plb1 Agpat4 Agpat1 Agpat2 Slc44a3 Slc44a4 Dgat2 Slc44a5 Gpam Dgat1 Cds1 Gpat2 Cpne1 Cpne3 Cpne6 Cpne7 Pemt Pcyt2 Etnk2 Cept1 Etnk1 Pitpnm2 Etnppl Pld2 Pitpnm3 Chka Agpat3 Pitpnm1 Chkb Selenoi Phospho1 Lpcat1 Lpcat2 Mgll Miga2 Pla2g15 Miga1 Gpd2 Gpd1 Pld6 Stard7 Dgat2l6 Chat Alpi Tmem86b Cdipt Lclat1 Chpt1 Pctp Stard10 Lpin3 Lpin2 Pla2g6 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g4b Pla2g12a Mboat7 Lpcat3 Pla2g10 Lpcat4 Abhd4 Plaat3 Pnpla8 Pla2g5 Plaat1 Pla2g3 Plaat5 Mboat1 Mboat2 Osbpl5 Pla1a Osbpl8 Osbpl10 Ptdss1 Hadha Ptdss2 Hadhb Gpd1l GASTRULATION%REACTOME%R-RNO-9758941.1 Gastrulation Tfap2c Tfap2a Tfap2b G2 M CHECKPOINTS%REACTOME%R-RNO-69481.1 G2 M Checkpoints Rad50 Cdc25c Cdc25a Babam1 Babam2 Topbp1 Rbbp8 Psma4 Psma3 Brca1 Psma6 Psma5 Ywhae Uimc1 Psma2 Psma1 Rad1 Mcm7 Mcm8 Ywhag Psmd12 Dbf4 Psmd11 Orc5 Orc4 Hist1h2bq Orc6 Psmd14 Orc1 Psmd13 Orc3 Orc2 Psmb5 Psmb4 Rpa1 Rpa2 Cdc7 Psmb7 Tp53 Cdc6 Psmb6 Psmb1 Rpa3 Cdk2 Psmb3 Psmb2 Mcm3 Mcm4 Mcm5 Mcm10 Psma7 Mcm2 Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 H2bc6 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Ywhaq Ywhah Ywhab Sfn Ccnb2 Pias4 Ccnb1 Mre11 Kat5 Nbn Cdk1 Hus1 Ccnb2-ps2 Atrip Dna2 Blm Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Rps27a Ube2n Clspn Rad17 Uba52 Atm Atr Ccna1 Ccna2 Tp53bp1 Rmi2 Rmi1 Brip1 Brcc3 Pkmyt1 Herc2 Ubb Rnf168 Ubc Gtse1 Exo1 ABRAXAS1 Wee1 Rfc5 Ywhaz Rnf8 Rfc3 Rhno1 Rfc4 Wrn Nsd2 Psmb6l1 Rfc2 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity Cdk6 Ccnd1 Ccnd2 Cbfb Runx1 Ccnd3 Ptpn11 Pml PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 97%10230902 Phase 0 - rapid depolarisation Cacna2d2 Cacng8 Cacng4 Cacng6 Cacng7 Cacna1c Cacnb1 Cacnb2 CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress Rad50 Dynll1 Dynll2 Egln1 Egln2 Cdk4 Egln3 Epas1 H2ac18 Hif3a Cul3 Ube2d2 Ezh2 Hif1an Psma4 Wtip Psma3 Ajuba Hif1a Psma6 Cited2 Psma5 Ywhae Vhl Psma2 Limd1 Psma1 Cul2 Eloc Elob Atp6v0b Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Atp6v1g3 Atp6v0e2 Atp6v1c2 Psmb5 Atp6v1c1 Psmb4 Keap1 Atp6v0c Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Atp6v1e2 Gsk3b Atp6v1e1 Tcirg1 H2aj Atp6v1a Atp6v1b2 Psma7 Atp6v0d2 H3-3b Psmc5 Atp6v0d1 Hist3h2ba Atp6v1b1 Psmc2 Atp6v0e1 Psmc1 Atp6v1g2 Psmc4 Atp6v1g1 Psmc3 Atp6v1f Atp6v1d H2bc18 Psmd7 Slc46a1 Psmd6 Ube2d3 H2az2 Psmd8 Psmd2 Ube2d1 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Psmd1 Adrm1 Hist1h2ai Nploc4 Ufd1 Ehmt1 Nfe2l2 Alb Cox7a2l Cox6a1 Cox6a2 Hspa5 Higd1c Coxfa4 Cox6c2 Sirt1 Cycsl2 Hspa9 Cox6b1 Cox8a Cox6b2 Mul1 Cox8c Cox7b Cox4i1 Cox4i2 Mt-co3 Cox7c Mt-co2 Cycs Trim21 Cox7a1 Cox7a2 Cox5a Cox5b Mt-co1 Ppara Clec1b Hsp90aa1 Ern1 Ncf1 Ncf2 Sod1 Ncf4 Hsp90ab1 Nup93 Rxra Nup50 Pgr Nup35 Nup54 Nup98 Tbl1x Nup58 Nup37 Nup205 Hsph1 Pom121 Prdx3 Rps19bp1 Nup107 St13 Nup188 Prdx6 Tgs1 Bach1 Tpr Nox4 Cryab Nup160 Esr1 Hsbp1 Erf Rae1 Ndc1 Bag5 Bag3 Crebbp Nup85 Bag2 Bag1 Gpx3 Nup42 Cyba Gpx6 Nup62 Gpx5 Nup43 Hdac3 Gpx8 Cybb Nup88 Gpx7 Aaas Cebpb Xpo1 Hspa14 Hspa13 Nup214 Ranbp2 Id1 Tbl1xr1 Hikeshi Nup155 Foxo3 Hsf1 Nup133 Nudt2 Nup210 Ubxn7 Nup153 Ets1 Ets2 Fkbp4 Ero1a Abcc1 Fkbp5 Hspb8 Ptges3 Tp53 Hspa4 Lamtor5 Dnajc2 Rptor Txnrd2 Akt1s1 Dnaja2 Ncor2 Lamtor3 Dnaja4 Rraga Carm1 Dnaja1 Lamtor4 Hspa12b Ep300 RragB Hspa12a Lamtor1 Dnajb6 Dnajb1 Rragc Sod3 Lamtor2 Ccs Rragd Mtor Rheb Cdkn1b Mlst8 Slc38a9 Rb1 Arnt Ncoa2 Med1 Prdx1 Srxn1 Sqstm1 Mios Depdc5 Fnip1 Fnip2 Samtor Szt2 Castor2 Castor1 Sesn2 Sesn1 Kics2 Itfg2 Wdr24 Nprl3 Nprl2 Flcn Wdr59 Sh3bp4 Ep400 H1-1 H1-0 Asf1a H1-5 Cabin1 H1-4 Hira H4f3 Ubn1 Hmga2 Hmga1 P4hb Lmnb1 Txn Gsr Hspa8 Gpx2 Gpx1 Cat Nr3c2 Nr3c1 Atf6b Mbtps1 Txn2 Ar Apoa1 Eif2s3 Eif2s2 Eif2s1 Eef1a1 Map3k5 Tnik Cdkn2b Cdkn2d Actr1a Mink1 Prdx2 Map4k4 Prdx5 Mapkapk5 Dctn1 Dctn2 Akt3 Hba1 Hbb Akt2 Dctn4 Akt1 Txnrd1 Fabp1 Blvrb Hmox1 Hmox2 Blvra Mapk9 Mapk7 Mapk8 Mapk1 Rps27a Eif2ak3 Hspa2 Mapk3 Sirt3 Sod2 Camk2a Skp1 Uba52 Ring1 Fos Hspa1b Ube2s Phc2 Hspa1a Ccne1 Ccne2 Cbx6 Ube2c Phc1 Ly96 Cdc27 Cdc26 Cbx4 Rps6ka3 Cdc23 Hspa1l Cbx2 Phc3 Anapc10 Anapc16 Cdk6 Anapc15 Rps6ka1 Sin3a Anapc5 Sin3b Anapc4 Bmi1 Anapc1 Rps6ka2 Anapc2 Fzr1 Btrc Tlr4 Anapc7 Ube2e1 Cdc16 Rnf2 Actr10 Map2k7 Map2k6 Mdm4 Ubb Ubc Mapkapk3 Mapk14 Jun Mapkapk2 Map2k3 Cul1 Mapk10 Smarcd3 Mapk11 Dync1li2 Dync1li1 Pgrmc2 Terf2 Terf1 Tinf2 Rpa1 Rpa2 Acd Terf2ip Rpa3 Cdk2 Hm13 Pot1 Prkci Map1lc3b Stip1 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Apob Dync1h1 Mre11 Kat5 Nbn Creb3l3 Crebrf Dync1i2 Atf6 Camk2g Camk2d Camk2b Dync1i1 Kdm6b Sec13 Oma1 Gstp1 Atm Ccna1 Ccna2 H2ab2 H2ac4 Rbx1 Vcp Psmb6l1 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 97%10231020 CLEC7A inflammasome pathway Pycard Malt1 Casp8 Il1b NADPH REGENERATION%REACTOME%R-RNO-389542.1 NADPH regeneration Aco1 Idh1 DS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022923.1 DS-GAG biosynthesis Chst14 Chst15 Dse Ncan Bcan Bgn Cspg5 Cspg4 Vcan Dsel Dcn Ust GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 97%10228942 Gamma-carboxylation of protein precursors Pros1 Ggcx Bglap F7 Proc F2 F10 Proz F9 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-RNO-6814848.1 Glycerophospholipid catabolism Pnpla6 Gde1 Enpp6 LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions Cacng8 Adam23 Cacng4 Cacng2 Cacng3 Dlg4 Adam22 Stx1b Stx1a Lgi2 Lgi3 Lgi4 Lgi1 Adam11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors Grik2 Grik1 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-RNO-6807505.1 RNA polymerase II transcribes snRNA genes Tbp Gtf2a1 Cdk7 Gtf2a2 Gtf2b Taf8 Rprd1a Rprd1b Taf6 Taf5 Gtf2e1 Cdk9 Pou2f2 Gtf2e2 Ncbp2 Ncbp1 Supt4h1 Pou2f1 Srrt Ints4 Ints13 Ints5 Ints14 Ints6 Ints11 Ints7 Ints12 Ints8 Ints10 Ints9 Zc3h8 Ints1 Rprd2 Ints2 Ints3 Sp1 Nabp1 Nabp2 Ccnk Rpap2 Ccnt2 Ice2 Snapc3 Snapc4 Snapc1 Snapc2 Ssu72 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Polr2i Phax Ell2 Polr2j Ell3 Pcf11 Taf11 Ell Taf13 Gtf2f2 Gtf2f1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-RNO-1253288.1 Downregulation of ERBB4 signaling Ubb Nedd4 Ubc Uba52 Wwp1 Rps27a Itch Src ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-RNO-9027284.1 Erythropoietin activates RAS Irs2 Grb2 Epo Epor Jak2 Rapgef1 Shc1 Vav1 Lyn Crkl APOPTOSIS%REACTOME%R-RNO-109581.1 Apoptosis Dynll1 Dynll2 Bcl2l1 Hmgb1l2 Hmgb1l1 Kpnb1 Prkcq Kpna1 Fnta Lmna Casp6 Lmnb1 Cd14 Ywhae Ywhag Ctnnb1 Dsg2 Apc Bcl2l11 Prkcd Bax Bid Fadd Ripk1 Bad Ppp3cc Ywhaq Ywhah Ptk2 Ywhab Pmaip1 Sptan1 Sfn Bmf Casp7 Gsn Gas2 Vim Mapt Sh3glb2 Add1 Plec Gsdmd Cycsl2 Cdh1 Rock1 Cycs Mapk8 Mapk1 Stk26 Stk24 Pkp1 Mapk3 Oma1 Ticam2 Ocln Hmgb2 Clspn Bmx Gsdme Dnm1l Traf2 Ticam1 Nmt1 Ppp3r1 Birc2 Opa1 Diablol1 Dsp Casp9 Apaf1 Dcc Xiap Septin4 Apip Dsg3 Gzmb Appl1 Tjp1 Bak1 Ly96 Acin1 Satb1 Bcap31 Dffa Dffb Tjp2 Dsg1 Tlr4 Hmgb1-ps34 H1-1 H1-0 Ywhaz Casp8 H1-5 H1-4 Tradd Fas H4f3 Cflar Casp3 Faslg Tnfsf10 ACETYLATION%REACTOME DATABASE ID RELEASE 97%10228912 Acetylation Nat1 Nat2 Nat3 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding Klb Fgf19 Fgfr4 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism Prkag2 Adipoq Tkt Cacna1e Cacna1a Adra2a Adra2c Adipor2 Adipor1 Marcks Rapgef4 Taldo1 Rapgef3 Abcc8 Rap1a Mlxipl Kcnb1 Kcns3 Plcb3 Ffar1 Plcb2 Plcb1 Cd36 Gng10-ps1 Kcnc2 Kcng2 Slc2a1 Adcy5 Adcy6 Gnas Prkaca Prkacb Cacna1c Gnai2 Gnai1 Prkab2 Prkca Gna11 Prkar1a Itpr3 Gna14 Itpr2 Prkar1b Gng3 Gng5 Gcgr Gng4 Gnaq Gng7 Gng8 Gngt1 Prkar2a Cacna1d Gnb2 Gnb1 Gnb4 Gnb3 Slc2a2 Gnb5 Gng11 Gng12 Cacna2d2 Acsl3 Acsl4 Gcg Kcnj11 Cacnb3 Glp1r Itpr1 Cacnb2 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%10228982 Mitochondrial transcription initiation Tfb2m Tfam Polrmt ACTIVATION OF TRKA RECEPTORS%REACTOME%R-RNO-187015.1 Activation of TRKA receptors Ntrk1 Ngf AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%10230518 Autophagy Prkag1 Chmp2b Dynll1 Prkag2 Dynll2 Ube2d2 Csnk2a2 Dync1li2 Csnk2a1 Chmp3 Dync1li1 Atg7 Chmp7 Becn1 Pik3c3 Chmp6 Csnk2b Lamtor5 Pik3r4 Rptor Lamtor3 Gabarapl2 Rraga Lamtor4 RragB Lamtor1 Src Rragc Atg3 Lamtor2 Mtmr14 Rragd Rb1cc1 Pcnt Map1lc3a Uvrag Fundc1 Mtor Atg10 Pgam5 Pink1 Rheb Atg13 Atg5 Tomm7 Atg14 Atg12 Tomm40 Tomm22 Gabarapl1 Mlst8 Slc38a9 Tomm20 Mtmr3 Vdac2 Atg9b Vdac3 Atg101 Vdac1 Ambra1 Tomm70 Ube2d3 Wdr45b Atg9a Wdr45 Usp30 Mterf3 Atg16l2 Atg16l1 Wipi2 Wipi1 Atg4b Atg4c Atg4a Atg4d Nbr1 Park7 Pex5 Prkab2 Prkab1 Map1lc3b Chmp4c Cftr Arl13b Tbk1 Ulk1 Optn Gabarap Dync1h1 Dync1i2 Dync1i1 Prkn Rps27a Ube2l3 Ube2n Sqstm1 Uba52 Atm Tsc2 Tsc1 Mfn1 Prkaa1 Mfn2 Ubb Chmp4bl1 Ubc Prkag3 Chmp2a CD28 CO-STIMULATION%REACTOME%R-RNO-389356.1 CD28 co-stimulation Cd28 Pik3cg Ppp2r1b Map3k8 Ppp2r1a Cd86 Cd80 Akt3 Akt2 Akt1 Mapkap1 Ppp2cb Ppp2ca Ctla4 Trib3 Pdpk1 Rac1 Ppp2r5b Map3k14 Ppp2r5a Pak3 Cdc42 Them4 Pik3cb Ppp2r5e Pik3cd Pik3ca Ppp2r5d Vav1 Lyn Yes1 Src Pik3r1 Pik3r2 Pik3r3 Prr5 Grb2 Fyn Mtor Pak1 Rictor Mlst8 Lck Pak2 Pik3r5 Grap2 Pik3r6 SPRY REGULATION OF FGF SIGNALING%REACTOME%R-RNO-1295596.1 Spry regulation of FGF signaling Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Src Ubb Grb2 Ppp2cb Ubc Ppp2ca Uba52 Braf Cbl Mknk1 Ptpn11 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria Ywhae Ppp3r1 Ywhag Ywhaz Ppp3cc Ywhaq Ywhah Ywhab Bad Sfn NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission Gria1 Gng10-ps1 Adcy3 Adcy4 Adcy1 Ap2m1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Adcy5 Adcy6 Adcy9 Cacng8 Prkaca Cacng4 Prkacb Cacng2 Prkcg Cacng3 Gnai2 Gnai1 Prkca Gnai3 Grin2a Gabrg2 Camk4 Arhgef9 Gabrg3 Prkar1a Grin3a Prkar1b Calm3 Grik5 Gng3 Grik2 Gnal Grik1 Grik4 Grik3 Gng5 Grin2d Gng4 Grin2c Chrnb4 Pick1 Chrna3 Gabra4 Gng7 Gabra3 Chrnd Chrnb2 Gabra6 Gng8 Gngt1 Gabra5 Chrne Gabra2 Gnat3 Chrng Chrna4 Gabra1 Prkar2a Akap5 Gnb2 Gnb1 Lrrc7 Gnb4 Glra3 Gnb3 Glra2 Gnb5 Glra1 Gng11 Gng12 Actn2 Camk1 Grip1 Gabrr1 Gabrr3 Gabrr2 Gabrq Gabrb1 Gabrb3 Gabrb2 Nefl Chrnb3 Grip2 Gria4 Gria3 Kcnj3 Kcnj2 Gria2 Epb41l1 Grin1 Chrna2 Dlg1 Chrna1 Dlg2 Dlg3 Myo6 Chrna7 Dlg4 Grin2b Gabbr1 Chrna6 Chrna5 Chrna9 Gabbr2 Rps6ka6 Tspan7 Prkcb Kcnj9 Kcnj6 Kcnj5 Kcnj4 Camk2g Camk2d Camk2b Glrb Ncald Kcnj10 Kcnj12 Htr3b Htr3a Kcnj15 Kcnj16 Ap2b1 Camk2a Rps6ka3 Rps6ka1 Rps6ka2 Nsf Ap2a2 Ap2a1 Ap2s1 PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis Prps1 Prps2 Prps1l3 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%10229566 G beta:gamma signalling through PI3Kgamma Pik3cg Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Akt3 Gnb5 Gng11 Akt2 Gng12 Rhoa Akt1 Gng3 Gng10-ps1 Gng5 Pdpk1 Gng4 Gng7 Pik3r5 Pik3r6 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism Aldh1a1 Tkfc Glyctk Aldob Khk NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229738 Nephrin family interactions Nck2 Fyn Kirrel1 Kirrel2 Kirrel3 Nphs1 Nck1 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-RNO-399997.1 Acetylcholine regulates insulin secretion Gna11 Plcb3 Gna14 Marcks Plcb2 Plcb1 Gnaq Prkca MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%10228276 Malate-aspartate shuttle Mdh2 Slc25a13 Slc25a22 Got1 Got2 Slc25a18 Mdh1 Slc25a11 Slc25a12 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport Arfgap3 Copa Dynll1 Arfgap2 Dynll2 Arfgap1 Kif3a Kif3b Nbas Kif3c Rab3gap2 Use1 Rab3gap1 Copb2 Rab1b Arf1 Copb1 Cope Klc1 Kif21a Dync1li2 Kif21b Dync1li1 Napa Klc4 Klc3 Klc2 Kif20a Kif20b Kifap3 Pla2g4a Galnt1 Galnt2 Rint1 Rab1A Rab18 Bicd2 Bicd1 Agpat3 Pafah1b3 Pafah1b2 Pafah1b1 Zw10 Actr1a Dctn1 Dctn2 Dctn4 Bnip1 Kif18a Kif18b Kdelr2 Kif19 Kdelr3 Dync1h1 Tmed9 Kif11 Kif12 Kif15 Kif1c Kif1a Kif1b Kdelr1 Dync1i2 Kif6 Rab6b Rab6a Dync1i1 Arf4 Kif9 Arf3 Kifc1 Stx18 Kifc2 Kif22 Kif23 Kif28 Tmed10 Kif27 Kif16b Pla2g6 Racgap1 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Copz2 Kif4b Kif26b Copz1 Kif4a Arf5 Kif26a Nsf Napb Actr10 Kif5a Kif5b Kif13b Napg Kif2a Kif2b Kif2c Arcn1 Cenpe RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%10230592 RHO GTPases Activate WASPs and WAVEs Mapk1 Nckap1 Actr2 Actb Actr3 Abl1 Arpc1b Arpc1a Mapk3 Wasf3 Wasf2 Wasf1 Abi2 Abi1 Cyfip2 Cyfip1 Rac1 Actg1 Cdc42 Wipf3 Wipf1 Btk Arpc3 Arpc2 Ptk2 Nckipsd Arpc5 Grb2 Arpc4 Brk1 Baiap2 Nck1 Nckap1l WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229866 Wax biosynthesis Awat1 Far2 Far1 Awat2 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 97%10230904 Phase 1 - inactivation of fast Na+ channels Kcnd3 Kcnd2 Kcnd1 Kcnip3 Kcnip4 Kcnip1 Kcnip2 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME%R-RNO-9834899.1 Specification of the neural plate border Tfap2c Tfap2a Tfap2b HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%10230772 HATs acetylate histones Kansl1 Kansl2 H2bc6 Kat7 H2bc4 Hist1h4m Ing4 H2bc1 Rbbp7 Pax3 Hat1 Jade1 Jade2 Jade3 Kat6b Msl2 Mcrs1 Msl3 Msl1 Brpf1 Ogt Kat6a Hist1h2bq Wdr5 Ncoa2 Brpf3 Phf20 Kat8 Meaf6 Hist3h2ba Ing5 H2bc18 Hcfc1 Brd1 Atf2 Kansl3 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230730 Nuclear Envelope (NE) Reassembly Chmp2b Nup37 Kpnb1 Nup205 Pom121 Ppp2r1a Nup107 Nup188 Lmna Lmnb1 Nup160 Ndc1 Nup85 Nup43 Chmp3 Chmp7 Lbr Chmp6 Nup155 Nup133 Emd Ccnb2 Ccnb1 Ube2i Vrk1 Ankle2 Tubal3 Vrk2 Rcc1 Spast Banf1 Cdk1 Ccnb2-ps2 Ppp2r2a Tuba4a Tuba3b Tubb4b Tubb4a Tuba1a Tuba1c Cc2d1b Tubb2b Tubb2a Ist1 Sirt2 Tuba8 Tubb6 Tubb3 Tubb1 Ran Sec13 Vps4a Ppp2ca Rangap1 Chmp4c Tuba1b Ahctf1 Chmp4bl1 Sumo1 Nup93 Nup35 Chmp2a Nup98 DEPYRIMIDINATION%REACTOME%R-RNO-73928.1 Depyrimidination Tdg Nthl1 Ogg1 Ung Neil2 Mbd4 Neil1 Smug1 GENE SILENCING BY RNA%REACTOME%R-RNO-211000.1 Gene Silencing by RNA Ago3 Ago2 H2bc6 Ago1 Dicer1 Tarbp2 H2bc4 Hist1h4m H2bc1 Tsnax Ran Ipo8 H2ac18 Hist1h2ai Hist1h2bq Tsn Polr2c Polr2a Polr2b H2aj Polr2g Polr2h H2ab2 Polr2e H3-3b Polr2f Hist3h2ba Polr2i H2ac4 Polr2j H2bc18 Tnrc6c Tnrc6a Tnrc6b Ago4 H2az2 Prkra LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%10230750 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Crebbp Irf3 Ep300 Ctnnb1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine Tdg Nthl1 Ogg1 Ung Neil2 Mbd4 Neil1 Smug1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-RNO-2173788.1 Downregulation of TGF-beta receptor signaling Smad2 Smurf2 Smad3 Rps27a Smad7 Tgfb1 Bambi Ubb Ubc Strap Uba52 Tgfbr1 Tgfbr2 Stub1 Mtmr4 AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation Ngf Arhgdia Ngfr Rhoa CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 97%10228134 CDC6 association with the ORC:origin complex Orc2 Mcm8 Cdc6 Orc5 Orc4 Orc6 Orc1 Orc3 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis Mocos Mocs3 Mocs1 Nfs1 Gphn DIGESTION%REACTOME%R-RNO-8935690.1 Digestion Alpi Gucy2c Pir Guca2b Guca2a Chit1 Si Amy2 Lct Chia Clps Pnlip Lipf Cel Pnliprp2 Pnliprp1 SIGNALING BY FGFR3%REACTOME%R-RNO-5654741.1 Signaling by FGFR3 Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Gab1 Frs2 Braf Frs3 Mknk1 Shc1 Fgf16 Fgf17 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Galnt3 Fgf5 Fgf8 Fgf9 Pik3ca Src Pik3r1 Fgfr3 Nras Ubb Grb2 Ubc Kras Sos1 Hras Cbl Ptpn11 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-RNO-379398.1 Enzymatic degradation of Dopamine by monoamine oxidase Maoa Comt CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling Plxna4 Cdk5r1 Plxna3 Cdk5 Plxna2 Gsk3b Nrp1 Dpysl2 Dpysl3 Dpysl4 Dpysl5 Fyn Sema3a Plxna1 Crmp1 Fes RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%10231536 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Neil1 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230940 Intraflagellar transport Ift56 Dynlrb1 Dynll1 Ift70a2 Dynll2 Dynlt5 Ift70b Kif3a Dynlt2 Kif17 Kif3b Ift20 Ift43 Ift22 Kif3c Ift81 Ift27 Cluap1 Ift46 Dync2i1 Dync2li1 Ift25 Dync2i2 Dynlt2b Ift80 Traf3ip1 Ift140 Ift52 Ttc21b Ift57 Kifap3 Ift122 Wdr35 Dync2h1 Tnpo1 Ift172 Wdr19 Trip11 Ift74 Dynlrb2 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 97%10231468 Biosynthesis of maresin-like SPMs Cyp3a18 Cyp3a1 Cyp3a62 Cyp2c66 Cyp2d4 Cyp3a2 Cyp2c11 Cyp2e1 Cyp3a9 Cyp1a2 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-RNO-5685939.1 HDR through MMEJ (alt-NHEJ) Rad50 Rad52 Polq Fen1 Nbn Parp2 Xrcc1 Lig3 Parp1 Rbbp8 Brca2 Mre11 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%10228894 FXIIa, PKa activate coagulation factors Gp1bb F12 Gp1ba Klkb1 Kng1 F11 Gp5 Gp9 F9 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein St8sia6 St3gal6 Ctsa St3gal4 St3gal2 St8sia3 Srd5a3 St3gal3 St6galnac5 St6galnac6 St3gal1 Neu2 Glb1 Neu3 Neu4 Neu1 St8sia5 St3gal5 Dpm1 Dpm2 Dpm3 Slc35c1 Cmas Alg9 Alg8 Alg6 Slc35a1 Alg5 Alg3 Alg2 Alg1 Gmds Gne Nus1 Pmm2 Pmm1 Nudt14 Npl Dhrsx Slc17a5 Nanp Nans St8sia1 Mpi St6galnac3 Dhdds Dolpp1 Fuom St6gal2 Dolk Alg13 Nagk Alg14 Gnpnat1 Alg12 Amdhd2 Mpdu1 Uap1 Fpgt Gmppa Gfpt1 Gfpt2 Pgm3 Fcsk Renbp St6galnac1 St6galnac2 Dpagt1 Gfus St8sia4 St8sia2 St6gal1 Mvd SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-RNO-192105.1 Synthesis of bile acids and bile salts Abcd3 Osbpl1a Akr1c3l1 Ch25h Amacr Hsd17b4 Osbpl3 Cyp39a1 Osbpl2 Osbpl7 Ncoa2 Osbpl6 Baat Akr1c18 Osbpl9 Akr1c19 Hsd3b7 Scp2 Cyp8b1 Akr1d1 Cyp7b1 Akr1c1 Akr1c21 Nr1h4 Akr1c9 Acox2 Cyp46a1 Cyp27a1 Acot8 Osbp Akr1c12l1 Slc27a5 Slc27a2 Abcb11 Cyp7a1 Rxra Akr1c12 Akr1c13 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 97%10229888 Protein folding Csnk2b Gnb2 Pdcl Gnb1 Sphk1 Cct6b Cct3 Gnb4 Rgs7 Gnb3 Cct2 Gnb5 Cct7 Rgs9 Tcp1 Csnk2a2 Cct8 Cct6a Csnk2a1 Cct5 Cct4 MELANIN BIOSYNTHESIS%REACTOME%R-RNO-5662702.1 Melanin biosynthesis Slc45a2 Tyr Oca2 Dct Tyrp1 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs Alox5 Alox15 Ptgs2 Alox12 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 97%10228372 GTP hydrolysis and joining of the 60S ribosomal subunit LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Eif5b Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl4 Rps14 Rpl13 Rps15 Rpl14 Rpl5 Rps16 Rpl15 Rpl3 Rps17 Rps18 Rpl17 Rps19 Rpl18 Rpl19 Rpl35 Rpl36 Rpsa Uba52 Rpl10 Rpl37 Rpl38 Rpl11 Rps10 Rpl39 Rpl8 Rpl12 Rps11 Rps3 Rpl9 Rps2 Rpl10a Rpl6 Rps13 Rps4x Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 LOC134480579 Rps8 Rps5 Rps6 Rpl24 Ubc Rpl26 Fau Rpl23a Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling Prkar1a Prkar2a Prkar1b Prkaca Prkacb ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%10230488 Organelle biogenesis and maintenance Dynll1 Dynll2 Kif3a Smo Kif3b Kif3c Ywhae Atp5mc1 Atp5f1e Atp5f1d Atp5pb Atp5f1c Ywhag Atp5pd Glud1 Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Kifap3 Tuba4a Tubb4b Tubb4a Nek2l1 Tuba1a Tfdp1 E2f4 E2f5 Rpgrip1l Ift140 Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Cpap Wdr35 Dync2h1 Ift172 Wdr19 Inpp5e Arl13b Sirt5 Pde6d Actr1a Dctn1 Dctn2 Cycsl2 Rab11a Plk1 Exoc3 Tnpo1 Exoc4 Exoc5 Exoc6 Cdk1 Exoc1 Exoc2 Cycs Arf4 Exoc7 Exoc8 Csnk1e Acss2 Idh2 Sirt3 Sod2 Gabpa Tp73 Hsp90aa1 Cct3 Bbs2 Cct2 Bbs10 Mkks Bbs12 Arl6 Ttc8 Tcp1 Lztfl1 Bbip1 Bbs7 Cct8 Bbs5 Trip11 Bbs4 Cct5 Cct4 Ppp2r1a Gmnn Pcnt Ift74 Dynlrb2 Ift56 Dynlrb1 Ift70a2 Dynlt5 Ift70b Dynlt2 Kif17 Ift20 Prkaca Ift43 Ift22 Ift81 Ift27 Cluap1 Nphp4 Cep97 Ift46 Dync2i1 Csnk1d Cep192 Dync2li1 Ift25 Dync2i2 Dynlt2b Ift80 Cep78 Cep76 Traf3ip1 Tmem67 Cep72 Fbf1 Cep70 Plk4 Cep89 Cep83 Cep57 Tmem216 Unc119b C2cd3 Cep63 Mark4 Alms1 Septin2 Kif24 Ttbk2 Cep43 Tctn3 Cep41 Tctn1 Tctn2 Ninl B9d1 Atat1 Cc2d2a Tubb5 Arl3 Odf2 Iqcb1 Haus7 Ahi1 Haus8 Nphp3 Haus4 Nphp1 Haus5 Rp2 Haus6 Sstr3 Cep162 Haus1 Sclt1 Pafah1b1 Cngb1 Nedd1 Pcm1 Grhl3 Gmnc Mcidas Ssna1 Grhl2 Tubg1 Grhl1 Akap9 Sfi1 Cetn2 Cep250 Cep135 Cep131 Cdk5rap2 Cep152 Cep290 Cep164 Ccp110 Dync1h1 Mchr1 Dync1i2 Mt-atp8 Thoc2l Rab3ip Cnga4 Pkd1 Cnga2 Mt-atp6 Asap1 Gbf1 Clasp1 Rab8a Ckap5 Rho Mapre1 B9d2 Nde1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-RNO-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Chm Rabggta Rabggtb EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-RNO-72613.1 Eukaryotic Translation Initiation Eif4ebp1 Eif4e Eif5 Eif1ax Eif4a2 Eif4a1 Pabpc1 Eif5b Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Rpl4 Eif3e Rps14 Eif3h Rps15 Eif3g Rpl5 Eif3b Rps16 Eif3a Rpl3 Eif3d Rps17 Eif3c Rps18 Eif2b3 Rps19 Eif2b2 Eif2b5 Eif2b4 Rpl35 Eif2b1 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-RNO-169893.1 Prolonged ERK activation events Mapk1 Rap1a Rapgef1 Mapk3 Ywhab Ntrk1 Crk Frs2 Ngf Braf Map2k2 Kidins220 Map2k1 Crkl SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006927.1 Signaling by Non-Receptor Tyrosine Kinases Lrrk2 Gpnmb Bcar1 Ccnd1 Arap1 Hbegf Elmo2 Elmo1 Dok1 Btc Cdk4 Rps27a Stat3 Socs3 Egfr Hif1a Ptpn1 Akt1 Arhgap35 Uba52 Rasa1 Ccne1 Rac1 Srms Cdk2 Stap2 Rhoa Erbb2 Ereg Egf Nras Ubb Ubc Kras Sfpq Erbb3 Khdrbs1 Nrg2 Khdrbs3 Crk Hras Nrg1 Khdrbs2 Ptk6 Nrg3 Cdkn1b Cbl Pxn IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855196.1 IP3 and IP4 transport between cytosol and nucleus Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%10230532 Synthesis of PIPs at the ER membrane Pi4k2b Sbf1 Pi4ka Sacm1l NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%10228644 Nucleotide Excision Repair Gtf2h5 Pold3 Rad23b Ercc2 Nfrkb Ccnh Cops5 Ercc1 Ercc3 Ercc4 Cdk7 Ino80e Ino80d Tfpt Ino80c Pias3 Ino80b Actr5 Sumo2 Actr8 Ruvbl1 Polk Pole3 Pole2 Ino80 Pole4 Actl6a Cops3 Cops4 Cops6 Rpa1 Rpa2 Rpa3 Cops2 Pole Cops8 Yy1 Rnf111 Znf830 Aqr Usp7 Uvssa Tcea1 Ercc6 Usp45 Cetn2 Xab2 Cops7a Ppie Cops7b Actg1 Prpf19 Xpa Ddb2 Ube2i Chd1l Lig3 Xpc Rad23a Pias1 Ube2v2 Rps27a Ube2n Isy1 Mcrs1 Uba52 Xrcc1 Lig1 Ddb1 Cul4a Parp2 Pold1 Gps1 Parp1 Polr2c Polr2a Pold4 Polr2b Cul4b Polr2g Polr2h Polr2e Polr2f Ubb Mnat1 Polr2i Ubc Sumo1 Polr2j Rbx1 Sumo3 Rfc5 Pold2 Rfc3 Gtf2h2 Gtf2h1 Rfc4 Pcna Rfc1 Gtf2h3 Rfc2 SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 Lrrk2 Gpnmb Bcar1 Ccnd1 Arap1 Hbegf Elmo2 Elmo1 Dok1 Btc Cdk4 Rps27a Stat3 Socs3 Egfr Hif1a Ptpn1 Akt1 Arhgap35 Uba52 Rasa1 Ccne1 Rac1 Srms Cdk2 Stap2 Rhoa Erbb2 Ereg Egf Nras Ubb Ubc Kras Sfpq Erbb3 Khdrbs1 Nrg2 Khdrbs3 Crk Hras Nrg1 Khdrbs2 Ptk6 Nrg3 Cdkn1b Cbl Pxn CARDIAC CONDUCTION%REACTOME DATABASE ID RELEASE 97%10228812 Cardiac conduction Akap9 Kcnd3 Kcnd2 Kcnd1 Kcnh2 Kcnq1 Kcna5 Dmpk Atp1a2 Fxyd3 Kcnj2 Fxyd4 Atp1a1 Atp1a4 Fxyd1 Fxyd2 Atp1a3 Fxyd7 Fxyd6 Kcnk13 Ahcyl1 Pln Tnni3 Ryr2 Kcnk10 Kcnk16 Ryr1 Kcnk18 Fkbp1b Trdn Kcnk4 Trpc1 Kcnk2 Ces1d Kcnk1 Mme Atp1b1 Atp1b3 Kcnj4 Atp1b2 Camk2g Kcnk9 Kcnip3 Camk2d Kcnip4 Camk2b Kcnip1 Kcnk7 Kcnip2 Kcnk6 Kcnj12 Kcnj14 Atp2a1 Atp2b1 Atp2b4 Cacng8 Atp2a3 Atp2b3 Prkaca Atp2a2 Cacng4 Cacng6 Cacng7 Cacna1c Kcne5 Kcne4 Kcne3 Kcne2 Clic2 Itpr3 Camk2a Itpr2 Slc8a1 Calm3 Asph Slc8a2 Nppc Npr1 Nppa Npr2 Slc8a3 Corin Stim1 Adam22 Abcc9 Kcnk12 Kcnk15 Kcnk5 Cacna2d2 Nos1 Kcnj11 Itpr1 Cacnb1 Cacnb2 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 97%10231322 E3 ubiquitin ligases ubiquitinate target proteins Pex13 Ube2d1 H2bc6 Ube2v2 H2bc4 Pex12 H2bc1 Rps27a Prkdc Ube2l3 Ube2n Pex5 Ube2d2 Bcl10 Pex10 Uba52 Ube2b Ube2a Hist1h2bq Cdc73 Skic8 Ube2e1 Ctr9 Paf1 Leo1 Rraga Rnf181 Ubb Shprh Ubc Rad18 Rnf152 Rnf40 Rnf20 Rnf144a Hltf Wac Pex2 Pcna Ube2d3 Pex14 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 97%10231524 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Atxn3 Foxo4 KINESINS%REACTOME%R-RNO-983189.1 Kinesins Kifc1 Kifc2 Kif22 Kif3a Kif23 Kif28 Kif3b Kif27 Kif16b Kif3c Racgap1 Klc1 Kif21a Kif21b Klc4 Klc3 Klc2 Kif18a Kif4b Kif18b Kif26b Kif19 Kif4a Kif26a Kif20a Kif20b Kifap3 Kif5a Kif5b Kif13b Kif11 Kif12 Kif15 Kif1c Kif1a Kif1b Kif2a Kif2b Kif6 Kif2c Cenpe Kif9 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%10228166 Processive synthesis on the lagging strand Pold3 Rpa1 Fen1 Rpa2 Lig1 Prim2 Pold1 Rpa3 Prim1 Pold4 Pola2 Pola1 Pold2 Dna2 Pcna SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 97%10229362 Synthesis of dolichyl-phosphate Dhrsx Srd5a3 Dhdds Nus1 Dolpp1 Mvd Dolk TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pold3 Gtf2h5 Ercc2 Ccnh Cops5 Ercc1 Ercc3 Ercc4 Cdk7 Polk Xab2 Pole3 Pole2 Pole4 Cops7a Ppie Cops7b Cops3 Cops4 Cops6 Rpa1 Rpa2 Rpa3 Cops2 Prpf19 Xpa Pole Cops8 Lig3 Rps27a Znf830 Isy1 Aqr Uba52 Usp7 Uvssa Xrcc1 Tcea1 Ercc6 Ddb1 Lig1 Cul4a Pold1 Gps1 Polr2c Polr2a Pold4 Polr2b Cul4b Polr2g Polr2h Polr2e Polr2f Mnat1 Ubb Polr2i Ubc Polr2j Rbx1 Rfc5 Pold2 Rfc3 Gtf2h2 Rfc4 Gtf2h1 Pcna Rfc1 Rfc2 Gtf2h3 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%R-RNO-1234158.1 Regulation of gene expression by Hypoxia-inducible Factor Cited2 Crebbp Epas1 Hif3a Ep300 Arnt Hif1a ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111446.1 Activation of BIM and translocation to mitochondria Dynll1 Mapk8 Bcl2l11 PI METABOLISM%REACTOME%R-RNO-1483255.1 PI Metabolism Pip4k2b Pip4k2c Pip4k2a Pitpnb Pik3c2b Mtmr7 Arf1 Mtmr6 Ocrl Mtmr9 Inpp5f Pi4k2b Inpp4a Rab5a Pikfyve Inpp4b Rab4a Mtm1 Fig4 Pik3c3 Rufy1 Vac14 Mtmr12 Mtmr4 Pi4k2a Pnpla6 Enpp6 Pik3r4 Synj1 Pip5k1a Tnfaip8 Pik3r1 Pik3r2 Pik3r3 Pip5k1b Tnfaip8l2 Mtmr14 Tnfaip8l3 Tnfaip8l1 Synj2 Inpp5k Inppl1 Mtmr3 Pik3c2a Arf3 Pik3r5 Pik3r6 Pik3cg Bmx Ptpn13 Gde1 Mtmr1 Inpp5d Rab14 Pip4p1 Pik3cb Pik3cd Sbf1 Pik3ca Inpp5j Pten Plekha8 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Inpp5e Pi4kb Pip5k1c Pi4ka Pik3c2g Tpte2 Sacm1l OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 97%10230188 Ovarian tumor domain proteases Otud7a Ube2d1 Traf6 Ikbkg Rps27a Otud7b Esr1 Traf3 Uba52 Ripk1 Rnf128 Otub1 Tp53 Tnip2 Apc Nod2 Nod1 Pten Rhoa Ubb Ripk2 Ubc Cdk1 Otud3 Tnip3 Vcp Tnip1 Zranb1 Yod1 Vcpip1 Otub2 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%10231748 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) Cdc42 Cbll1 Vav2 Rps27a Ctsb Arhgef4 Src Jup Ctsl Ubb Ctss Ubc Uba52 Ctnnd1 Cdh1 Ctnna1 Rac1 Tiam1 Ctnnb1 Farp2 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229620 Signal regulatory protein family interactions Fyb1 Tyrobp Skap2 Grb2 Cd47 Sirpa Ptk2b REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%10231612 Regulation of Expression and Function of Type II Classical Cadherins Jup Zeb2 Cdh11 Adam19 Ctnnd1 Amot Sp1 Ctnnb1 Angptl4 METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K Ubiad1 Vkorc1 Vkorc1l1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 97%10229128 Adenylate cyclase activating pathway Adcy8 Adcy5 Adcy6 Adcy9 Gnal Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%10231504 Signaling by NOTCH4 Akt1 Ywhaz WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-RNO-5099900.1 WNT5A-dependent internalization of FZD4 Wnt5a Cltb Prkcg Ap2b1 Fzd4 Prkca Ap2a2 Ap2s1 Ap2a1 Prkcb Clta Arrb2 Cltc Ap2m1 Dvl2 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis Agps Gnpat Dhrs7b ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 C3 C2 C4 C5 C4b PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%10231558 Pexophagy Usp30 Ubb Map1lc3b Sqstm1 Ubc Uba52 Rps27a Nbr1 Atm Pex5 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-RNO-380320.1 Recruitment of NuMA to mitotic centrosomes Actr1a Tubg1 Dynll1 Akap9 Nme7 Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Csnk1d Cep192 Tubgcp2 Clasp1 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Mzt1 Mzt2 Cep43 Cep41 Ninl Ckap5 Numa1 Tubb5 Hsp90aa1 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Tubgcp3 Nde1 Nedd1 Pcm1 Ssna1 Tubg2 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%10228668 PCNA-Dependent Long Patch Base Excision Repair Pold3 Rpa1 Fen1 Rpa2 Lig1 Polb Pold1 Rpa3 Apex1 Pold4 Pole Pole3 Pole2 Rfc5 Pold2 Pole4 Rfc3 Rfc4 Pcna Rfc1 Rfc2 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%10231630 Regulation of CDH1 Function Cbll1 Eps15 Psma4 Psma3 Psma6 Psma5 Jup Psma2 Psma1 Ctnnd1 Cdh1 Psmd12 Ctnna1 Psmd11 Ctnnb1 Psmd14 Psmd13 Psmb5 Psmb4 Dnm2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Src Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Banp Psmd7 Psmd6 Psmd8 Psmd2 Rack1 Rps27a Psmd1 Adrm1 Uba52 Vcl Ctsb Mtbp Ctsl Ubb Fyn Ctss Ubc Psmb6l1 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229878 Dopamine receptors Drd2 Drd3 Drd4 Drd5 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 97%10228684 GPCR downstream signalling Pde3b Lpar5 S1pr3 S1pr2 S1pr5 S1pr4 Lpar3 Lpar1 Prkch Nras Grb2 Kras Sos1 Hras Mgll Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Daglb Dagla Ffar4 Ghrl Abhd12 Rgs7 Pdpk1 Mmp3 Src Rhoa Ngef Prkce Mcf2l Pik3r5 Tiam2 Plxnb1 Pik3r6 Arhgef15 Pik3cg Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Ednrb Fgd3 Ednra Arhgef39 Arhgef38 Npff Arhgef33 Rrh Ect2 Prex1 Trio Apln Trhr Mcf2 Tas2r39 Plekhg5 Plekhg2 Oprd1 Net1 Rasgrf2 Tas2r38 C3ar1 Arhgef10l Galr2 Galr3 Galr1 Sstr5 Sstr4 Sstr3 Sstr2 Pde10a Sstr1 Avpr1b Pde11a Rxfp3 Avpr1a Htr5a Tbxa2r Gpr183 Pde2a Ppbp Fpr1 Itpr1 Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Rgsl1 Ghsr Rgs4 Rgs5 C5 Rgs2 Rgs20 Ptgfr Rgs3 Rgs17 Pnoc Rgs1 Rgs16 Tas2r16 Rgs8 Gnaz Tas2r13 Pcp2 Ppy Gpsm3 Tas2r135 Gpsm2 Gpsm1 Tas2r136 Gna12 Nmb Rgs21 Oxtr Rgs18 Lpar6 Rgs19 Xcr1 Rgs13 Gpr18 Rgs14 Grpr Rgs12 Gpr17 Ccr1l1 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Tas2r4 Tas2r3 Brs3 Tas2r7 Gabbr1 Vav1 Ptger3 Gabbr2 Pik3r1 Ptger1 Pik3r2 Pik3r3 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Mtnr1b Agtr2 Gpr37 Gpr39 Gal Penk Rgr Hcrt Npb Gpr143 Grp Opn1mw Kiss1r Shc1 Gcgr Ccl19 Nps Ccl11 Ptafr Npw Npffr1 Npy Npffr2 Ptgdr2 Rho Pik3ca Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Qrfprl Gpr4 Sos2 Gcg Qrfp Ccl27 Agt Npsr1 Prok1 P2ry10 P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 F2rl1 Rhoc Tas2r40 Rhob Fpr2l1 Tas2r41 Hcar1 Adra2a Prokr2 Adra2c Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Gpr65 Gpr68 Cxcr4 Cxcr5 Oprl1 Adra1b Adra1a Adra1d Uts2 Btk Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Casr Cxcl10 C5ar1 Ffar3 Arrb1 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Chrm1 Hrh1 Chrm3 Chrm5 Hrh4 Chrm4 Tac3 Tac1 Drd3 Drd4 Opn4 Opn3 Pmch Trpc7 Gper1 Oxgr1 Opn5 Sucnr1 Trpc3 Itpr3 Pyy Itpr2 Adora1 Adora3 Rln3 Ltb4r2 F2r Arrb2 Cxcl16 F2 Cxcl13 F2rl2 F2rl3 Tas2r119 Opn1sw Oxt Trh Npy5r Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Qrfpr Psap Htr1d Htr1f Tas2r120 Xcl1 Htr1b Kiss1 Ccl9 P2ry6 Cxcl9 P2ry4 Ccl6 Akt3 P2ry2 Ccl5 Akt2 P2ry1 Ccl4 Akt1 Gast Hcrtr2 Hcrtr1 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Uts2b Tas2r105 Itsn1 Tas2r107 Gpr37l1 Ackr3 Cck Cnr1 Cnr2 Uts2r Sst Oprk1 App Mapk7 Mapk1 Hbegf Mapk3 Agtr1 Ppp2cb Gnat2 Ppp2ca Rps6ka3 Rps6ka1 Rps6ka2 Ppp2r5d Prkcq Ppp2r1b Ppp2r1a Egfr Chrm2 Vav3 Vav2 Plcb4 Plcb3 Pla2g4a Pdyn Plcb2 Pak1 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Itgb1 Gnaq Gng7 Pde4d Gng8 Gngt1 Gnat3 Prkar2a Cdk5 Pde1b Pde1c Gnb2 Pde1a Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Rgs9 Gnat1 Tiam1 Kalrn Arhgef7 Cdc42 Rock2 Rock1 Avp Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Adrb2 Tacr1 Grk3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling Psmd8 Psmd2 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Nfkb2 Psma6 Uba3 Chuk Psma5 Psma2 Ube2m Psma1 Skp1 Uba52 Fbxw11 Psmd12 Psmd11 Psmd14 Psmd13 Map3k14 Psmb5 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Relb Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%10228426 The phototransduction cascade Fnta Fntb Nmt1 Calm3 Pde6a Pde6b Gngt1 Rgs9bp Ppef1 Gnb1 Metap1 Rho Metap2 Cnga1 Gnb5 Grk1 Grk4 Rgs9 Camkmt Cngb1 Gnat1 Gucy2e Rcvrn Nmt2 Sag Guca1b Guca1a Gucy2f Pde6g RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%10231294 RAB GEFs exchange GTP for GDP on RABs Rab3il1 Rab31 Rab35 Ccz1 Rab38 Ulk1 Rab3gap2 Akt3 Rin3 Dennd4c Rab3gap1 Rin1 Akt2 Rin2 Dennd4a Dennd4b Ywhae Akt1 Rab1b Mon1b Mon1a Rab5a Dennd5a Rinl Dennd1a Gapvd1 Dennd1b Dennd1c Trappc2l Dennd5b Als2 Gdi1 Rab5c Hps1 Gdi2 Trappc10 Rab7a Rab7b Dennd2a Hps4 Dennd2c Trappc12 Rab3a Trappc11 Trappc13 Dennd3 Rab6b Rab6a Rab5b Trappc9 Als2cl Trappc8 Rab3ip Rabgef1 Chm Trappc5 Trappc4 Trappc3 Trappc2 Rab27a Rab9a Rab39a Trappc1 Rab9b Rab27b Trappc6b Trappc6a Rab21 Rab8b Rab8a Rab1A Rgp1 Rab10 Ankrd27 Rab13 Rab12 Rab14 Rab18 Sbf2 Chml Sbf1 Ric1 Dennd6a Dennd6b Madd INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%10230110 Interleukin-35 Signalling Il6st Tyk2 Canx Jak2 Ebi3 Stat3 Stat1 Il12rb2 Il12a POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230862 Positive epigenetic regulation of rRNA expression Tbp H2bc6 H2bc4 Hist1h4m H2bc1 Taf1d H2ac18 Taf1a Taf1c Kat2a Taf1b Hist1h2ai Sf3b1 Polr1b Polr1c Polr1a Polr1f Polr1g Polr1e Polr1h Ercc6 Mybbp1a Hist1h2bq Actg1 Gsk3b Myo1c Ep300 H2aj H2ab2 Polr2h Polr2e Smarca5 H3-3b Polr2f Hist3h2ba Kat2b Dek H2ac4 Ddx21 H2bc18 Baz1b H2az2 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%10230888 ATP-dependent chromatin remodelers Snrpg Snrpb H2ac18 Ss18 Pbrm1 Mta1 Smarcd1 Mta2 Smarcb1 Mta3 Smarcd3 Mbd3 Snrpd1 Smarcd2 Dpf1 Bicral Bicra Dpf2 Dpf3 Brd9 Chd3 Brd7 Arid1a Snrpd3 Arid1b Gatad2a Hist1h2bq Ctnnb1 Ss18l1 Gatad2b Bcl7a Wdr5 Bcl7b Bcl7c Actl6a Bcl11a Bcl11b Phf10 Snrpepl2 Skic8 Smarce1 Chd1 Smarcc1 Chd2 Smarca2 Ssrp1 Ctr9 Paf1 H2aj H3-3b Hist3h2ba H2bc18 H2az2 H2bc6 Rbbp4 Phf5a Zfp592 H2bc4 Fam124b Hist1h4m Ctcf H2bc1 Smndc1 Cdk2ap1 Rbbp7 Nr2f2 Zmynd8 Ikzf3 Ikzf1 Chd5 Chd6 Hist1h2ai Chd7 U2surp Zfp827 Tcf19 Zfp532 Adnp Cbx1 Pwwp2a Mbd3l1 Mbd3l2 Cbx3 Cdc73 Snrpa1 Dhx15 Chd4 Hdac2 Sf3a1 Sf3a2 Hdac1 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 Mbd2 Actg1 Chd8 Leo1 Ube2i Snrpn Cherp Nr2c2 Rbm17 Phf6 Ddx46 Ddx42 Puf60 H2ab2 H2ac4 Smarca4 Sumo1 Snrpf TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%10230408 Tandem pore domain potassium channels Kcnk10 Kcnk16 Kcnk18 Kcnk9 Kcnk7 Kcnk4 Kcnk13 Kcnk2 Kcnk1 Kcnk6 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-RNO-166665.1 Terminal pathway of complement C5 C6 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%10228940 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Pros1 Bglap F7 Gas6 Proc F2 F10 Proz F9 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%10230308 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Cd22 Cd19 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Dapp1 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 Blnk ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Btk Syk ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 Vav1 ENSRNOG00000065283 ENSRNOG00000062976 Trpc1 ENSRNOG00000063549 Pik3r1 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 Sh3kbp1 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Pik3ap1 Itpr3 Itpr2 Stim1 Pik3cd Grb2 Sos1 Cd79a Ptpn6 Cd79b Itpr1 Nck1 LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism Aldh7a1 Crym Dlst Aass Aadat Pipox Hykk Dld Slc25a21 Gcdh Phykpl Dhtkd1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%10230918 Degradation of GLI1 by the proteasome Psmd8 Psmd2 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Gli1 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Numb Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Sufu Itch Psmd7 Psmd6 Psmb6l1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%10228694 Post NMDA receptor activation events Rps6ka1 Prkar2a Rps6ka2 Prkaca Prkacb Camk4 Rps6ka6 Prkar1a Camk1 Prkar1b Calm3 Rps6ka3 Camkk1 Camkk2 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Kcnj15 Kcnj16 Kcnj3 Kcnj2 Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gabbr1 Gnb4 Gnb3 Gnb5 Gng11 Gabbr2 Gng12 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gng10-ps1 Kcnj10 Kcnj12 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%10230948 Trafficking of myristoylated proteins to the cilium Arl3 Nphp3 Unc119b Rp2 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%10229622 Cell-Cell communication Ost4 Tmem258b Cbll1 Pvr H2ac18 Ezh2 Psma4 Psma3 Psma6 Angptl4 Psma5 Psma2 Psma1 Csnk2a2 Dad1 Csnk2a1 Psmd12 Psmd11 Suz12 Hist1h2bq Pcsk6 Ctnnb1 Psmd14 Psmd13 Hace1 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 H2aj Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Banp Sp1 Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Psmd1 Adrm1 Hist1h2ai Mogs Nectin1 Cdh9 Cdh8 Nectin4 Cdh7 Cdh6 Cdh3 Prkcsh Cadm3 Cdh24 Cadm2 Cadm1 Mtbp Pcsk7 Grb2 Afdn Ang2 Fyn Cdh18 Cdh17 Cdh13 Cdh12 Cdh10 Ganab Rnf19b Plec Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Megf11 Sec11c Sec11a Pard6a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Nfkb1 Cd47 Pard3 Dst Pard6g Uba52 F11r Rela Vcl Sirpa Ctsb Cdh2 Tyrobp Sdk1 Ctsl Ubb Sdk2 Ctss Ubc Pip5k1c Nck1 Eps15 Jup Ctnnd1 Rac1 Vav2 Itga6 Pomt1 Arhgap32 Prkci Pomt2 Src Kirrel1 Kirrel2 Kirrel3 Nphs1 Pxn Jak2 Amot Arhgef6 Arhgef4 Pard6b Vasp Tesk1 Ilk Fermt2 Actn1 Fblim1 Parvb Flna Parva Itgb1 Flnc Cdh15 Tiam1 Farp2 Nck2 Skap2 Zeb2 Cdh11 Adam19 Cd151 Itgb4 Cdh1 Ctnna1 Cdc42 Tyk2 Il6st Canx Stat3 Fyb1 Birc2 Xiap Furin Il6 Il6r H2ab2 Nectin2 H2ac4 Smarca4 Rpn2 Rpn1 Ostc Ptk2b Psmb6l1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10230564 Activated NOTCH1 Transmits Signal to the Nucleus Ubb Ubc Uba52 Rps27a Itch Dtx2 Dtx4 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs Shc2 Nab2 Ppp2r1b Dnal4 Ppp2r1a Chd4 Egr2 Mapk11 Clta Ntrk1 Ngf Cltc Pcsk5 Rac1 Pcsk6 Map2k1 Plcg1 Dock3 Ntf3 Ralgds Rap1a Ntf4 Ntrk2 Bdnf Sh3gl2 Pik3r1 Src Rhoa Pik3r2 Map2k2 Ap2m1 Atf1 Mapk7 Mapk1 Rapgef1 Mapk3 Sgk1 Ap2b1 Irs1 Irs2 Ntrk3 Ppp2cb Ppp2ca Frs2 Braf Vrk3 Shc1 Furin Kidins220 Rps6ka3 Rps6ka5 Rps6ka1 Rps6ka2 Pik3cb Pik3ca Ppp2r5d Ywhab Shc3 Dusp3 Dusp4 Nras Srf Grb2 Ap2a2 Fyn Ap2a1 Kras Ap2s1 Sos1 Dusp7 Crk Dusp6 Hras Mapkapk3 Mapk14 Mapkapk2 Crkl SIGNALING BY FGFR2%REACTOME%R-RNO-5654738.1 Signaling by FGFR2 Ppp2r1a Ncbp2 Ncbp1 Hnrnph1 Gab1 Fgf10 Fgf3 Fgf22 Fgf7 Rbfox2 Esrp2 Plcg1 Esrp1 Tial1 Tia1 Fgfbp3 Fgfbp1 Pik3r1 Src Spry2 Mapk1 Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Frs2 Braf Frs3 Mknk1 Shc1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Polr2c Pik3ca Polr2a Ptbp1 Polr2b Polr2g Polr2h Hnrnpa1 Polr2e Nras Polr2f Ubb Grb2 Polr2i Hnrnpf Ubc Kras Polr2j Sos1 Hras Cbl Ptpn11 Gtf2f2 Gtf2f1 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME%R-RNO-8932506.1 DAG1 core M1 glycosylations Dag1 Pomt1 Pomgnt1 Pomt2 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%10230106 Interleukin-20 family signaling Il24 Ifnl3 Il22ra2 Il20rb Ifnlr1 Jak3 Il20ra Tyk2 Il22ra1 Jak2 Stat3 Stat1 Stat5a Il10rb Stat5b Ptpn11 Il22 Ifnl1 Il20 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME%R-RNO-428643.1 Organic anion transport by SLC5 17 25 transporters Slc5a8 Slc17a5 Slc25a10 Slc25a1 Slc5a12 Slc25a11 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-RNO-964739.1 N-glycan trimming and elongation in the cis-Golgi Man1a2 Man1a1 Mgat1 Manea Man1c1 REGULATION OF TP53 DEGRADATION%REACTOME%R-RNO-6804757.1 Regulation of TP53 Degradation Chek2 Usp2 Ccng1 Ppp2r1b Ppp2r1a Rps27a Sgk1 Akt3 Daxx Akt2 Akt1 Mapkap1 Ppp2cb Ppp2ca Uba52 Usp7 Atm Pdpk1 Ccna1 Ccna2 Tp53 Cdk2 Phf20 Prr5 Ubb Mdm4 Rffl Ubc Mtor Cdk1 Rictor Mlst8 Rnf34 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 97%10228954 Synthesis of glycosylphosphatidylinositol (GPI) Pigm Pigl Pigg Pigf Pigh Pign Pigq Pigp Dpm2 Pigw Pigc Pigv Pigb Pigx Piga VEGFA-VEGFR2 PATHWAY%REACTOME%R-RNO-4420097.1 VEGFA-VEGFR2 Pathway Nck2 Itgb3 Shc2 Bcar1 Nckap1 Elmo2 Elmo1 Hspb1 Vegfa Akt3 Prkcz Mapk12 Wasf3 Akt2 Mapk13 Wasf2 Wasf1 Akt1 Jup Mapkap1 Mapk11 Axl Abi2 Cyba Ctnnd1 Rasa1 Abi1 Cybb Trib3 Ctnna1 Cyfip2 Cyfip1 Pdpk1 Rac1 Ctnnb1 Vav3 Pak3 Plcg1 Cdc42 Them4 Rock2 Vav2 Rock1 Sphk1 Vav1 Pik3r1 Src Rhoa Pik3r2 Prkcb Mtor Pak1 Mlst8 Pxn Pak2 Prkaca Prkacb Prkcd Prkca Calm3 Cav1 Hsp90aa1 Pik3cb Pik3ca Ptk2 Nras Nos3 Prr5 Ncf1 Fyn Ncf2 Kras Ncf4 Rictor Crk Hras Brk1 Itgav Shb Mapkapk3 Kdr Mapk14 Baiap2 Nck1 Mapkapk2 Sh2d2a Ptk2b Nckap1l FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229926 Free fatty acids regulate insulin secretion Gna11 Plcb3 Gna14 Acsl3 Ffar1 Acsl4 Plcb2 Cd36 Plcb1 Gnaq METALLOPROTEASE DUBS%REACTOME%R-RNO-5689901.1 Metalloprotease DUBs Bard1 Babam1 Rps27a Babam2 H2ac18 Ep300 Brca1 Hist1h2ai Brcc3 Stam Uimc1 Ubb Kat2b H2ac4 Nlrp3 Ubc ABRAXAS1 Uba52 Stambpl1 Stambp H2ac25 Mysm1 Psmd14 Abraxas2 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-RNO-5684264.1 MAP3K8 (TPL2)-dependent MAPK1 3 activation Ikbkg Btrc Map3k8 Tnip2 Rps27a Cul1 Nfkb1 Chuk Ubb Skp1 Ubc Uba52 Fbxw11 Ikbkb POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels Kcnj16 Kcnj1 Kcnj10 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 97%10230716 SUMO is conjugated to E1 (UBA2:SAE1) Sae1 Sumo1 Uba2 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 97%10228530 Homology Directed Repair Pold3 Rad50 Rad52 Ercc1 Ercc4 Babam1 Babam2 Topbp1 Rbbp8 Brca2 Brca1 Rad51ap1 Polh Polk Uimc1 Pole3 Rad1 Pole2 Pole4 Hist1h2bq Rpa1 Rpa2 Rpa3 Cdk2 Pole Hist3h2ba H2bc6 H2bc4 Hist1h4m H2bc1 Ppp4r2 Pias4 Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Lig3 Dna2 Sirt6 Rad51c Blm Rad51b Chek1 Ube2v2 Rad9a Rad9b Bard1 Top3a Rps27a Abl1 Palb2 Ube2n Firrm Ppp4c Clspn Rad17 Xrcc3 Slx1b Xrcc2 Uba52 Xrcc1 Atm Atr Ccna1 Ccna2 Tp53bp1 Fen1 Lig1 Mus81 Parp2 Pold1 Rmi2 Parp1 Fignl1 Rmi1 Pold4 Brip1 Brcc3 Herc2 Ubb Polq Rnf168 Ubc Exo1 ABRAXAS1 Sumo3 Rfc5 Rnf8 Pold2 Rfc3 Rhno1 Slx4 Rfc4 Wrn Pcna Nsd2 Rfc1 Spidr Rfc2 Rad51 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling Ap2a2 Ap2a1 Ap2s1 Ntrk1 Clta Dnal4 Ngf Cltc Ap2m1 Ap2b1 Sh3gl2 FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism Hacd2 Hacd3 Prkag2 Hacd4 Mcat Acad11 Ptgs1 Ppt2 Akr1c3l1 Ppt1 Acoxl Crot Acox3 Slc25a20 Acot9 Acot7 Alox12 Gpx4 Morc2 Alox5 Lta4h Alox15 Ppard Abcc1 Cyp2c66 Them4 Cyp2c11 Ptges3 Akr1c1 Cyp1a1 Akr1c9 Ephx2 Cyp1a2 Phyh Ltc4s Eci2 Ptgs2 Hacl1 Hsd17b12 Acaca Akr1c12l1 Mlycd Fasn Acox1 Pla2g4a Ehhadh Acaa1b Elovl2 Acly Elovl3 Mmut Elovl5 Elovl1 Hao2 Elovl6 Pecr Elovl7 Tecrl Decr2 Awat1 Nudt19 Gpx2 Acot1 Them5 Acot2 Aloxe3 Pcca Gpx1 Alox12b Acot5 Acadvl Acot3 Acot4 Pccb Cpt1a Cpt1b Pon3 Pon1 Prkab2 Eci1 Hsd17b8 Acbd4 Mid1ip1 Slc22a5 Hsd17b3 Amacr Acadm Echs1 Hsd17b4 Alox5ap Mmaa Faah Cyp2j16 Scp2 Cyp4f39 Cyp2j3 Crat Acox2 Cyp4f1 Decr1 Acot11 Cyp4a14 Scd1 Acot8 Acot12 Cyp4f3 Acot13 Cyp4f40 Cyp4a12 Cyp4b1 Slc27a2 Cyp4f4 Cyp4a10 Cyp4a2 Acsl1 Acsl5 Aldh3a2 Acsl6 Fads2 Abcd1 Fads1 Cbr4 Acbd5 Tecr Acsbg1 Acsbg2 Acaa2 Acbd6 Acsf3 Acsf2 Dbi Cpt2 Pon2 Cyp1b1 Alox15b Cyp2u1 Cyp8b1 Ndufab1 Pctp Thrsp Acads Cbr1 Tbxas1 Hpgds Ptges Ptgds Ptgis Ptges2 Ggt1 Akr1c18 Akr1c19 Akr1c21 Dpep1 Dpep2 Ggt5 Acsl3 Acsl4 Rxra Akr1c12 Mecr Akr1c13 Hadha Hadhb Mapkapk2 Acadl Hacd1 Hadh ARACHIDONATE METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonate metabolism Ptgs1 Akr1c3l1 Alox12 Gpx4 Alox5 Pon2 Lta4h Alox15 Cyp1b1 Alox15b Cyp2u1 Abcc1 Cyp2c66 Cyp2c11 Ptges3 Cyp8b1 Akr1c1 Cyp1a1 Akr1c9 Ephx2 Cyp1a2 Ltc4s Ptgs2 Akr1c12l1 Pla2g4a Awat1 Gpx2 Aloxe3 Gpx1 Alox12b Cbr1 Tbxas1 Pon3 Hpgds Pon1 Ptges Ptgds Ptgis Ptges2 Alox5ap Ggt1 Faah Akr1c18 Akr1c19 Cyp2j16 Cyp4f39 Akr1c21 Dpep1 Cyp2j3 Dpep2 Cyp4f1 Cyp4a14 Cyp4f3 Cyp4f40 Cyp4a12 Cyp4b1 Ggt5 Cyp4f4 Cyp4a10 Cyp4a2 Akr1c12 Akr1c13 Mapkapk2 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 97%10230780 HSP90 chaperone cycle for SHRs Actr1a Hspa8 Dynll1 Dynll2 Dctn1 Hspa2 Dctn2 Dctn4 Nr3c2 Nr3c1 Dync1li2 Hspa1b Hspa1a Dync1li1 Hspa1l Stip1 Fkbp4 Fkbp5 Hsp90aa1 Ptges3 Dnaja2 Ar Dnaja4 Dync1h1 Dnaja1 Actr10 Dnajb1 Hsp90ab1 Dync1i2 Dync1i1 Pgr MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%10231674 Mitochondrial unfolded protein response (UPRmt) Akt1 Hspa1b Hspa1a Sirt3 Dnaja1 Esr1 Hsf1 Foxo3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-RNO-8957275.1 Post-translational protein phosphorylation Pcsk9 P4hb Apoa2 Apoe Apoa5 Vcan Pnpla2 Ttgn1 Kng1 Fstl1 Chrdl1 Gpc3 Cp Serpina1 Mbtps1 Proc Serpinc1 Serpind1 Fgf23 Prkcsh Tnc Apoa1 Alb Dmp1 Notum Bpifb2 Apol2 C4b Apol7bl1 LOC120093819 C3 Apol7al1 C4 Apol9a Mgat4a Gas6 Ahsg Spp2 Fn1 Ltbp1 Fga Fgg Sdc2 Men1 Apob Chgb Pdia6 Ccn1 Amelx Qsox1 Lgals1 Scg2 Mxra8 Fam20a Fam20c Fuca2 Megf11 Stc2 Mia3 Wfs1 Bmp4 Hrc Serpina10 Fbn1 Ambn Tf Mepe Enam Bmp15 Igfbp7 Mfge8 Matn3 Rcn1 Vgf Hsp90b1 Vwa1 Prss23 Tmem132a Afp Meltf Adam10 Ano8 Igfbp5 App Igfbp4 Golm1 Igfbp1 Amtn Nucb1 Sparcl1 Cst3 Itih2 Dnajc3 Penk Msln Csf1 Spp1 Scg3 Ktn1 Il6 Ckap4 Timp1 Cdh2 Aplp2 Igfbp3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 97%10230702 FCERI mediated Ca+2 mobilization Tec ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 Nfatc3 ENSRNOG00000070810 Nfatc2 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 Vav3 ENSRNOG00000070192 Plcg1 Iglc1 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Btk Vav2 Syk ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 Vav1 ENSRNOG00000070986 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Lcp2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 Grap2 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 Txk ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Ppp3ca Lat ENSRNOG00000067643 Ppp3cb Nfatc1 Ppp3r1 Itk Calm3 Shc1 Grb2 Sos1 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855229.1 IP6 and IP7 transport between cytosol and nucleus Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 MET RECEPTOR ACTIVATION%REACTOME%R-RNO-6806942.1 MET Receptor Activation Met Hgfac Hpn Spint2 Spint1 Hgf CARBOHYDRATE METABOLISM%REACTOME%R-RNO-71387.1 Carbohydrate metabolism Tkt Chp1 Pgd Ugp2 Prps1 Prps2 Abo2 Gys1 Galk1 Dcxr B3gnt3 Fam20b Idua Ncan Bgn Pgm2 Cspg5 Taldo1 Cspg4 Xylt1 Vcan Xylt2 Hyal4 Pgls Hyal3 B3galt1 Ids Papss2 Hyal1 Papss1 Gusb Shpk B3galt6 B3galt5 Cryl1 Prps1l3 Gale Galm Slc2a1 Sdc4 Sdc3 Gpc1 Gpc3 Gpc2 Gpc4 Gpc6 Agrn Abcc5 Gpc5 Gns Slc35d2 G6pdx Slc35b3 Slc35b2 Slc26a2 Slc26a1 Slc26a11 Ctsl Gnpda1 Phkg1 Gpi Phkg2 Gaa Gnpda2 Eno3 Nup93 Agl Eno2 Pygl Nup50 Eno4 Pygm Hyal5 Phkb Pfkfb4 Akr1e2 Pfkfb3 Phka1 Nup35 Pfkfb2 Phka2 Nup54 Pfkfb1 Pc Nup98 Gyg1 Pgam2 Pgm1 Pgam1 Slc37a4 Tpi1 Nup58 Slc37a2 Nup37 Slc37a1 Nup205 Hkdc1 Pom121 Fbp1 Fbp2 Nup107 Gckr Pklr Nup188 Gapdhs Aldoc Tpr Bpgm Aldoa Nup160 Pfkl Rae1 Pgk1 Ndc1 Pgk2 Pck1 Nup85 Pfkm Pfkp Pck2 Nup42 Pgm2l1 Nup62 Nup43 G6pc1 Pkml1 Nup88 Gck Aaas Hk2 Hk3 Nup214 Adpgk Ranbp2 G6pc3 Tpi1l2 Nup155 Hs3st4 Nup133 Nup210 Hs3st1 Extl2 Nup153 Hs3st2 Naglu Hs3st5 Hs3st6 Hs3st3b1 Hpse2 Hpse Hs2st1 Ndst1 Ndst2 Ndst3 Ndst4 Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Sgsh Ext2 Ext1 Calm3 Aldh1a1 Slc9a1 Tkfc Glyctk Sord Aldob Akr1b1 Khk Glb1l B3gnt7 B3gnt2 Kera B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Fmod Glb1l2 St3gal6 Galns St3gal4 St3gal2 Hexa Lum Hexb St3gal3 B4gat1 Omd St6galnac6 St3gal1 Chst1 Chst3 Chst2 B4galt2 B4galt3 B3galt4 Acan Chst6 Fut2 Glb1 Fut1 Ogn Sdc1 Sdc2 Chst11 Chst12 Chsy1 Chsy3 Arsb Chst13 Chst14 Uxs1 Chst15 Dse Chpf Csgalnact2 Chst7 Chst9 Dsel Ust Akr1a1 Slc17a5 Sec13 Dcn B4galnt2 Galt Man2c1 Bcan Man2b1 Rpe Cd44 Gbe1 Dera Hyal2 Rbks Xylb Chp1l1 Has1 Has2 Has3 Cemip Pxylp1 Ppp1r3c B4galt7 Manba Fut4 Fut7 Fut9 Rpia INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%10229714 Integrin signaling Itgb3 Bcar1 Ptpn1 Akt1 Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rapgef4 Rapgef3 Shc1 Pdpk1 Rasgrp1 Rasgrp2 Tln1 Rap1a Syk Ptk2 Src Grb2 Csk Sos1 Crk INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 97%10228996 Insulin effects increased synthesis of Xylulose-5-Phosphate Tkt Taldo1 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%10230094 Synthesis of GDP-mannose Gmppa Mpi Pmm2 Pmm1 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling Cd28 Pik3cg Map3k8 Cd86 Cd80 Akt3 Akt2 Akt1 Mapkap1 Trib3 Pdpk1 Map3k14 Them4 Pik3cb Pik3cd Pik3ca Pik3r1 Pik3r2 Pik3r3 Prr5 Fyn Mtor Rictor Mlst8 Lck Pik3r5 Pik3r6 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%10229868 Striated Muscle Contraction Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Tmod1 Tmod4 Tmod2 Tcap Dmd Tpm2 Tpm1 Neb Tnni2 Tnni1 Myl4 Tmod3 Myh3 Des Mybpc2 Myl1 Actn3 Myl2 Mybpc3 Myl3 Myh6 Tnni3 Tpm4 Actn2 Vim M PHASE%REACTOME DATABASE ID RELEASE 97%10228872 M Phase Cenpl Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ndc80 Gorasp1 H2ac18 Lmna Psma4 Lmnb1 Psma3 Psma6 Psma5 Ywhae Psma2 Psma1 Csnk2a2 Csnk2a1 Ywhag Chmp3 Psmd12 Psmd11 Hist1h2bq Chmp7 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Chmp6 Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Ppp2r5e Kif20a Psmb3 Psmb2 H2aj Psma7 Psmc5 Hist3h2ba Tubal3 Psmc2 Rcc1 Psmc1 Spast Psmc4 Espl1 Psmc3 Ppp2r2a Tuba4a Tuba3b Tubb4b Tubb4a Nek2l1 Tuba1a Psmd7 Tuba1c Psmd6 Cc2d1b Tubb2b H2az2 Psmd8 Tubb2a Psmd2 Ist1 Ube2d1 H2bc6 Sirt2 Tuba8 Tubb6 H2bc4 Tubb3 Tubb1 Hist1h4m H2bc1 Ran Psmd1 Adrm1 Hist1h2ai Hdac8 Ofd1 Cpap Actr1a Dctn1 Dctn2 Rps27 Kmt5a Cnep1r1 Ctdnep1 Emd Ccnb2 Nek9 Ccnb1 Plk1 Lpin3 Lpin2 Vrk1 Vrk2 Prkcb Banf1 Cdk1 Ccnb2-ps2 Mapk1 Csnk1e Rps27a Nudc Mapk3 Ppp2cb Ppp2ca Uba52 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Golga2 Anapc2 Hsp90aa1 Anapc7 Ube2e1 Cdc16 Ppp2r5d Chmp4bl1 Ubb Ubc Nup93 Nup50 Cenpe Nup35 Nup54 Nup98 Chmp2a Chmp2b Nup58 Nup37 Nup205 Ppp2r1b Kpnb1 Ppp2r1a Pom121 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Rab1b Nup85 Nup42 Dync1li2 Nup62 Nup43 Nup88 Dync1li1 Aaas Xpo1 Nup214 Ranbp2 Lbr Nup155 Nup133 Nup210 Nup153 Ankle2 Itgb3bp Pcnt Prkaca Vps4a Prkca Csnk1d Cep192 Eml4 Tubgcp2 Set Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Rab1A Cep63 Chmp4c Alms1 Mzt1 Mzt2 Cep43 Cep41 Tuba1b Ninl Rab2a Numa1 Tubb5 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Haus1 Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Cdca5 Tubgcp3 Zw10 Pds5b Stag2 Stag1 Nedd1 Pds5a Smc1a Smc3 Blzf1 Wapl Ncaph2 Nipbl Mau2 Pcm1 Ssna1 Tubg2 Tubg1 Arpp19 Akap9 Ncapd3 Nme7 Sfi1 Fbxo5 Ncapg2 Rb1 Cetn2 Pttg1 Cep250 Gorasp2 Cep135 Cep131 Cdk5rap2 Mastl Mcph1 Cep152 Cep290 Clip1 Cep164 Ncapd2 Ncapg Smc4 Ncaph Smc2 Kif18a Ccp110 Dync1h1 Ube2i Dync1i2 Dync1i1 Phf8 Kif23 Sec13 Firrm Clasp1 Clasp2 Spc24 Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Mapre1 Zwint B9d2 Ska2l1 H2ab2 Bub1 Ppp1cc Taok1 Nde1 Rcc2 H2ac4 Sumo1 Kntc1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Cenpq Kif2c Cenpp Cenpo Cenpn Cenpm Mis12 Psmb6l1 Zwilch LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 97%10229736 Ligand-independent caspase activation via DCC Casp9 Dcc Appl1 Casp3 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%10230882 Release of Hh-Np from the secreting cell Ihh Gpc5 Notum Dhh Shh Disp2 Scube2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%10230300 Growth hormone receptor signaling Stat5a Gh1 Mapk1 Stat5b Jak2 Mapk3 Lyn Sh2b1 Ghr Prl Ptpn1 Prlr PHENYLALANINE METABOLISM%REACTOME%R-RNO-8964208.1 Phenylalanine metabolism Il4i1 Pcbd1 Pah Kyat1 Asrgl1 Qdpr REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%10231530 Regulation of FOXO transcriptional activity by acetylation Crebbp Kat2b Sirt1 Foxo1 Sirt3 Ep300 Foxo3 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 97%10231564 Signaling by CSF3 (G-CSF) Csf3 Ube2d1 Tyk2 Jak2 Syk Rps27a Gab2 Ube2d2 Lyn Hck Socs1 Socs3 Ubb Grb2 Cul5 Ubc Eloc Kras Elob Uba52 Shc1 Ptpn11 Ube2d3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors Prkcg Nsf Ap2b1 Prkca Gria1 Grip2 Gria4 Tspan7 Gria3 Ap2a2 Ap2s1 Ap2a1 Prkcb Gria2 Ap2m1 Grip1 Pick1 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 97%10228516 Synthesis of PA Acp6 Ddhd2 Agpat4 Agpat1 Agpat2 Liph Miga2 Lipi Pla2g2d Miga1 Pla2g2f Gpam Gpd2 Gpd1 Pla2g2a Pld6 Pla2g1b Gpat2 Pla2g4d Gpat4 Gpat3 Pla2r1 Pla2g4b Pla2g12a Lpcat4 Pla2g10 Pla2g5 Alpi Pld2 Lclat1 Agpat3 Pld1 Gnpat Pla2g4a Lpcat1 Gpd1l TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME DATABASE ID RELEASE 97%10231662 TGFBR3 regulates TGF-beta signaling Arrb1 Tgfbr3 Gipc1 Arrb2 Tgfbr1 Tgfbr2 Tgfb1 Tgfb2 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 97%10229694 Biosynthesis of specialized proresolving mediators (SPMs) Hpgd Alox5 Lta4h Alox15 Gstm4 Cyp2c66 Cyp2c11 Cyp2e1 Cyp1a1 Ephx2 Cyp3a9 Cyp1a2 Ltc4s Ptgs2 Cyp3a18 Cyp3a1 Cyp3a62 Cyp2d4 Cyp3a2 Alox5ap Alox12 Gpx4 PORPHYRIN METABOLISM%REACTOME%R-RNO-189445.1 Porphyrin metabolism Fech Uros Ppox Cox10 Alad Alas1 Alas2 Cox15 Hmbs Cpox Urod Slco1b2 Slco2b1 Ugt1a2 Ugt1a3 Ugt1a5 Fabp1 Gsta5 Blvrb Abcg2 Hmox1 Hmox2 Blvra Ugt1a1 Abcc1 Abcc2 Alb REGULATION OF APOPTOSIS%REACTOME%R-RNO-169911.1 Regulation of Apoptosis Opa1 Oma1 HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230618 Hyaluronan degradation Hyal1 Gusb Hyal2 Slc17a5 Chp1 Hexa Chp1l1 Hexb Cemip Slc9a1 Hyal5 Hyal4 Hyal3 Cd44 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 Cdk1 Ccnb2-ps2 Ccnb2 Nek9 Ccnb1 Plk1 DNA REPAIR%REACTOME DATABASE ID RELEASE 97%10228224 DNA Repair Rad50 Rad52 Eya2 Cops5 Eya1 Ercc1 Eya4 Ercc4 Babam1 Eya3 Babam2 H2ac18 Topbp1 Rbbp8 Ubxn1 Psma4 Brca2 Psma3 Brca1 Psma6 Rad51ap1 Polk Psma5 Uimc1 Ube2l6 Psma2 Poll Psma1 Rad1 Psmd12 Psmd11 Hist1h2bq Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 H2aj Psma7 Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 H2az2 Psmd8 Psmd2 Rnf111 H2bc6 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Hist1h2ai Ube2b Nploc4 Sprtn Ufd1 Usp45 Uba7 Wdr48 Usp10 Neil2 Neil1 Pnkp Pias1 Mapk8 Faap100 Rps27a Fancl Ube2n Fancm Fanca Fancb Fancc Fance Fancf Fancg Uba52 Faap24 Faap20 Gps1 Polr2c Polr2a Polr2b Mbd4 Polr2g Polr2h Smug1 Mpg Polr2e Polr2f Tdg Nthl1 Mnat1 Ubb Ogg1 Polr2i Ung Ubc Exo1 Mutyh Polr2j Rfc5 Pold2 Rfc3 Mad2l2 Gtf2h2 Gtf2h1 Rfc4 Pcna Rfc1 Gtf2h3 Rfc2 Gtf2h5 Pold3 Rev1 Msh6 Rad23b Ercc2 Nfrkb Ccnh Msh2 Ercc3 Cdk7 Ino80e Ino80d Pms2 Tfpt Mlh1 Ino80c Rev3l Ino80b Pias3 Actr5 Sumo2 Poli Actr8 Polh Ruvbl1 Pole3 Pole2 Ino80 Pole4 Trim25 Isg15 Actl6a Terf2 Cops3 Terf1 Cops4 Tinf2 Rpa1 Cops6 Rpa2 Tp53 Acd Terf2ip Rpa3 Cops2 Cdk2 Pot1 Pole Cops8 Yy1 Znf830 Alkbh5 Fto Aqr Usp7 Uvssa Tcea1 Ercc6 Rchy1 Rad18 Cetn2 Xab2 Cops7a Ppie Cops7b Actg1 Rif1 Ppp4r2 Paxip1 Xpa Pias4 Prpf19 Ddb2 Mre11 Chd1l Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Xpc Lig3 Lig4 Rad23a Dna2 Sirt6 Rad51c Blm Baz1b Rad51b Chek1 Chek2 Ube2v2 Neil3 Rad9a Rad9b Bard1 Top3a Prkdc Abl1 Palb2 Firrm Ppp4c Nhej1 Mcrs1 Clspn Isy1 Rad17 Kpna2 Xrcc6 Xrcc3 Slx1b Xrcc2 Tdp2 Xrcc5 Tdp1 Xrcc4 Xrcc1 Atm Atr Bap1 Ccna1 Ccna2 Tp53bp1 Ppp5c Pclaf Apbb1 Phf6 Fanci Dclre1a Kdm4b Fen1 Dclre1b Kdm4a Ddb1 Usp1 Lig1 Fancd2 Mus81 Polb Parg Ube2t Cul4a Parp2 Usp43 Pold1 Rmi2 Apex1 Haus3 Parp1 Fignl1 Dtl Adprs Rmi1 Fan1 Pold4 Brip1 Cul4b Brcc3 H2ab2 Smarca5 Herc2 Polq Rnf168 H2ac4 Sumo1 ABRAXAS1 Rbx1 Polm Sumo3 Rnf8 Dclre1c Rhno1 Vcp Slx4 Wrn Nsd2 Spidr Psmb6l1 Rad51 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%10231638 Ciprofloxacin ADME Abcg2 Slc22a1 Alb Slco1a4 METHYLATION%REACTOME%R-RNO-156581.1 Methylation Mtr Ahcy Gsto1 Tpmt Mtrr Mat2a Mat2b Cyp1a2 As3mt Mat1a Comt COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%10230578 Collagen biosynthesis and modifying enzymes P4hb Gpr162 Col14a1 Col10a1 Ppib Col1a2 Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Adamts3 Col24a1 Adamts2 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 Adamts14 P3h1 Crtap Pcolce2 Colgalt2 Col2a1 Col27a1 Col4a4 Col6a2 Serpinh1 Col23a1 Col6a5 Col6a6 Col4a5 Col6a3 Col8a1 Col4a6 Col8a2 Col18a1 Bmp1 Plod3 Tll2 Tll1 Plod1 Plod2 Col7a1 Col26a1 Col15a1 Col13a1 Col19a1 Col4a1 Col25a1 Col4a2 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231616 Regulation of CDH11 gene transcription Zeb2 Sp1 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%10229546 WNT mediated activation of DVL Dvl1 Pip5k1b Dvl3 Csnk2b Csnk2a2 Csnk1e Csnk2a1 Dvl2 TP53 REGULATES METABOLIC GENES%REACTOME%R-RNO-5628897.1 TP53 Regulates Metabolic Genes Prkag1 Prdx2 Prkag2 Prdx5 Cox7a2l Cox6a1 Gls Cox6a2 Akt3 Akt2 Higd1c Sesn3 Ywhae Akt1 Coxfa4 Cox6c2 Cycsl2 Txnrd1 Ywhag Tigar Cox6b1 Cox8a Cox6b2 Cox8c Gls2 Lamtor5 Rptor Lamtor3 Rraga Cox7b Lamtor4 RragB Lamtor1 G6pdx Rragc Lamtor2 Cox4i1 Rragd Txn Cox4i2 Mtor Rheb Mt-co3 Cox7c Mlst8 Prdx1 Slc38a9 Mt-co2 Gsr Cycs Gpx2 Cox7a1 Cox7a2 Cox5a Cox5b Mt-co1 Prkab2 Prkab1 Ywhaq Sesn2 Ywhah Sesn1 Ywhab Tsc2 Sfn Ddit4 Tsc1 Prkaa1 Gpi Ywhaz Prkag3 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 97%10230746 Postmitotic nuclear pore complex (NPC) reformation Nup133 Nup37 Nup205 Pom121 Ran Nup107 Sec13 Nup188 Ahctf1 Nup160 Ube2i Ndc1 Nup85 Sumo1 Rcc1 Nup43 Nup93 Rangap1 Nup35 Nup98 Nup155 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%10228580 RNA Polymerase II Transcription Termination Slbp Snrpg Snrpb Cpsf4 Cpsf6 Cpsf7 Cpsf1 Cpsf2 Cpsf3 Lsm10 Lsm11 Zfp473 Ncbp2 Ncbp1 Sympk Clp1 Snrpd3 Snrpepl2 Cstf2t Fip1l1 Pcf11 Cstf1 Papola Pabpn1 Nudt21 Snrpf Cstf2 Cstf3 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 97%10230362 Cross-presentation of particulate exogenous antigens (phagosomes) Ncf1 Ncf2 Cyba Ncf4 Cd36 Cybb Itgav SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 97%10229134 Signaling by TGF-beta Receptor Complex Itgb3 Tgfb1 Hdac1 Tgfb2 Prkcz Tgfb3 Cgn Bambi Ltbp3 Ltbp2 Cdk9 Ltbp4 Ltbp1 Itgb8 Strap Zfyve9 Tgfbr1 Tgfbr2 Men1 Mtmr4 Ncor2 Rhoa Fkbp1a Ppm1a Tgif1 Tgif2 Sp1 Ski Tfdp2 Tfdp1 Smad4 Ccnk Ube2d3 Atp1b4 Pard6a Ccnc Ube2d1 Trim33 Rnf111 Smurf2 Smad2 Mapk1 Smurf1 Smad3 Wwtr1 Usp9x Ccnt2 Rps27a Rbl1 E2f4 Smad7 Mapk3 E2f5 Skil Ube2m Pard3 Uba52 F11r Furin Itgb1 Stub1 Nedd8 Parp1 Itga8 Ubb Ubc Tgfbr3 Itgb6 Itgav Cbl AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-RNO-211163.1 AKT-mediated inactivation of FOXO1A Akt1 Foxo1 Akt3 Akt2 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 97%10229970 Regulation of actin dynamics for phagocytic cup formation Nckap1 Elmo2 Elmo1 Wasf3 Wasf2 ENSRNOG00000069193 Wasf1 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Abi2 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Abi1 ENSRNOG00000070415 Cyfip2 ENSRNOG00000070810 ENSRNOG00000066926 Cyfip1 ENSRNOG00000066406 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Vav3 ENSRNOG00000070192 Iglc1 Wipf3 ENSRNOG00000070159 ENSRNOG00000071049 Wipf1 Btk AABR07034736.1 Vav2 ENSRNOG00000065564 Arpc3 Myo5a ENSRNOG00000066971 Fcgr2 ENSRNOG00000063341 Arpc2 ENSRNOG00000065283 Myh9 ENSRNOG00000062976 Myo1c ENSRNOG00000063549 Nckipsd ENSRNOG00000063148 Limk1 Myo10 Igkvl13 AABR07065812.2 Arpc5 ENSRNOG00000063707 ENSRNOG00000067679 Arpc4 Cd3g Pak1 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Myo9b Ptk2 Grb2 Actr2 Actb Actr3 Arpc1b Arpc1a Actg1 Cdc42 Syk Vav1 Fcgr1a Mapk1 Abl1 Mapk3 Hsp90aa1 Hsp90ab1 Crk Brk1 Baiap2 Nck1 Nckap1l MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%10231648 MITF-M-regulated melanocyte development Tbx3 Mapk1 Tcf7l2 Rab27a Mapk3 Hdac1 Akt3 Hint1 Lef1 Aimp2 Crebbp Sirt1 Lars1 Tcf7 Csf1 Mark3 Tcf7l1 Xpo1 Sox10 Ctnnb1 Kars1 Rps6ka1 Sin3a Sytl2 Mars1 Myrip Dars1 Kit Myo5a Tnfsf11 Gsk3b Mitf Ep300 Qars1 Ube2i Sumo1 Kitlg Eprs1 Rars1 Iars1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 97%10228674 Transport of the SLBP independent Mature mRNA Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Ncbp2 Ncbp1 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nxf1 Eif4e Nup93 Nup50 Nup35 Alyref Nup54 Nup98 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-RNO-373076.1 Class A 1 (Rhodopsin-like receptors) P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 F2rl1 Fpr2l1 Hcar1 Adra2a Prokr2 Adra2c Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Gpr68 Cxcr4 Cxcr5 Oprl1 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Cxcl10 C5ar2 C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Chrm1 Hrh1 Chrm3 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Lpar5 Opn5 Plppr1 Sucnr1 Plppr4 Pyy Plppr5 Adora1 Plppr2 Adora3 Plppr3 Rln3 Ltb4r2 S1pr1 F2r Rln1 S1pr3 Cxcl16 S1pr2 F2 Cxcl13 S1pr5 F2rl2 S1pr4 F2rl3 Lpar3 Opn1sw Lpar1 Prlhr Oxt Ece1 Ece2 Trh Npy5r Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Qrfpr Insl3 Ptgir Psap Htr1d Htr1f Xcl1 Htr1b Htr1a Kiss1 Tshr Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 P2ry2 Ccl5 P2ry1 Ccl4 Ccl3 Hcrtr2 Hcrtr1 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Uts2b Gpr37l1 Ackr3 Ackr4 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Tshb App Agtr1 Chrm2 Pdyn Oprm1 Adora2b Adora2a Ednrb Ednra Npff Pomc Rrh Ptgdr Htr4 Apln Trhr Htr6 Oprd1 Htr7 C3ar1 Galr2 Galr3 Galr1 Cmklr1 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Tbxa2r Gpr183 Lhb Ppbp Fpr1 Gnrh1 Nmbr Fpr2 Ccr10 C3 Nln Avpr2 C5 Ptgfr Pnoc Ppy Cga Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Nmu Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger4 Ptger2 Ptger3 Fshr Ptger1 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Mtnr1b Agtr2 Avp Gpha2 Gpr37 Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Taar3 Taar2 Taar5 Rgr Taar1 Hcrt Npb Gpr143 Grp Opn1mw Kiss1r Ccl19 Ccl17 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npffr1 Npy Npffr2 Adrb2 Ptgdr2 Rho Pf4 Cx3cl1 Fpr2l3 Cysltr2 Cysltr1 Prok2 Qrfprl Gpr4 Ptgdrl Tacr1 Qrfp Ccl27 Agt Npsr1 Prok1 P2ry10 Mc3r BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231450 Biosynthesis of DPAn-3-derived protectins and resolvins Alox5 Alox15 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 97%10231040 MAP2K and MAPK activation Itgb3 Mapk1 Raf1 Mapk3 Fn1 Apbb1ip Fgb Fga Rap1b Fgg Mark3 Arrb2 Itga2b Braf Tln1 Map2k1 Vcl Rap1a Lamtor3 Il17rd Ywhab Wdr83 Src Ksr1 Cnksr2 Araf Arrb1 Lamtor2 Nras Pebp1 Csk Kras Hras Map2k2 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 97%10229668 Synthesis of PC Slc44a1 Slc44a2 Slc44a3 Slc44a4 Slc44a5 Mfsd2a Csnk2a2 Stard7 Csnk2a1 Chat Pemt Cept1 Csnk2b Chka Chkb Chpt1 Phospho1 Pctp Stard10 Pcyt1b Pcyt1a Abhd3 Lpin3 Lpin2 Lpcat1 ION CHANNEL TRANSPORT%REACTOME%R-RNO-983712.1 Ion channel transport Atp1a2 Fxyd3 Fxyd4 Atp1a1 Atp6v0b Atp1a4 Fxyd1 Fxyd2 Atp1a3 Atp6v0a4 Fxyd7 Fxyd6 Atp6v1g3 Pln Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp7b Atp6v0d2 Atp10a Atp10b Atp6v0d1 Atp10d Atp6v1b1 Atp4a Atp6v0e1 Atp4b Atp6v1g2 Atp11b Atp6v1g1 Atp11a Atp1b1 Atp6v1f Atp13a1 Atp1b3 Atp6v1d Atp11c Atp1b2 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a Atp2c1 Atp2c2 Atp9b Atp2a1 Atp9a Atp2b1 Atp2b4 Raf1 Atp2a3 Atp2b3 Atp2a2 Trpc7 Trpc3 Calm3 Adam22 Atp7a Ryr2 Asic5 Ryr1 Asic4 Fkbp1b Clca1 Clca2 Asic1 Asic3 Asic2 Clca4 Trdn Trpc5 Trpc1 Trpc4 Clcn2 Stoml3 Clcn1 Trpm2 Trpm1 Unc80 Ano10 Trpm8 Ano9 Trpm7 Camk2g Ano8 Camk2d Ano7 Camk2b Ano6 Ano5 Trpm4 Ano4 Trpm3 Ano3 Trpm6 Ano2 Ano1 Ttyh3 Ttyh1 Ttyh2 Stom Rps27a Sgk3 Sgk2 Sgk1 Trpv5 Trpv4 Trpv6 Scnn1a Scnn1b Clic2 Unc79 Scnn1g Camk2a Mcoln3 Asph Uba52 Lrrk1 Trpa1 Slc17a3 Trpv1 Trpv3 Mcoln1 Mcoln2 Trpv2 Nalcn Tpcn1 Trpc4ap Tsc22d3 Clcn6 Clcn7 Best4 Clcn4 Clcn5 Nek4 Wwp1 Bsnd Best1 Best3 Clcnkb Clcnka Best2 Ubb Ubc SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling Arhgef11 Rnd1 Arhgef12 Rock2 Rras Rock1 Rhoc Rhob Sema4d Rhoa Erbb2 Met Arhgap35 Rac1 Plxnb1 INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling Il15ra Grb2 Stat5a Stat5b Jak3 Sos2 Sos1 Stat3 Shc1 Il15 Il2rb TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%10228350 tRNA Aminoacylation Ppa1 Ppa2 LACTOSE SYNTHESIS%REACTOME%R-RNO-5653890.1 Lactose synthesis Slc2a1 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-RNO-5626978.1 TNFR1-mediated ceramide production Nsmaf Tnfrsf1a Rack1 Smpd2 Smpd3 Tnf APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response Mapk1 Mapk3 Gsdme Gsdmd Bax Cycsl2 Diablol1 Casp9 Apaf1 Septin4 Xiap Apip Casp7 Bak1 Cycs Casp3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling Ggt5 Ggt1 Ggt7 Chac1 Ggt6 Chac2 Gss Oplah Ggct Gclc Cndp2 Gclm GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation Akr1a1 Gsto1 Gsto2 Hpgds Gstp1 Gsta6 Gsta3 Gsta1 Gsta2 Gss Gsta5 Ggt1 Gstz1 Gstm4 Gstt2 Gstt1 Ggct Gclc Esd Cndp2 Gclm Gstk1 Ggt5 Chac1 Ggt7 Chac2 Ggt6 Gstm7 Gstm5 Gstm1 Oplah Gstm2 Mgst3 Mgst2 Mgst1 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation Nedd4 Ezh2 Psma4 Psma3 Psma6 Mta1 Mta2 Psma5 Mta3 Psma2 Mbd3 Psma1 Csnk2a2 Csnk2a1 Psmd12 Psmd11 Chd3 Suz12 Gatad2a Gatad2b Psmd14 Psmd13 Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Lamtor5 Mkrn1 Psmb1 Rptor Eed Psmb3 Lamtor3 Psmb2 Rraga Lamtor4 RragB Lamtor1 Psma7 Rragc Lamtor2 Psmc5 Rragd Psmc2 Psmc1 Psmc4 Mtor Psmc3 Rheb Mlst8 Slc38a9 Psmd7 Psmd6 Psmd8 Psmd2 Rbbp4 Rbbp7 Maf1 Sall4 Psmd1 Adrm1 Prex2 Usp7 Mecom Wwp2 Trim27 Otud3 Usp13 Frk Chd4 Hdac2 Akt3 Hdac1 Akt2 Akt1 Tnks2 Rnf146 Tnks Rps27a Uba52 Ring1 Xiap Phc2 Cbx6 Phc1 Cbx4 Cbx2 Stub1 Phc3 Bmi1 Rnf2 Pten Pml Ubb Ubc Psmb6l1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis Tcp1 Cct8 Cct6a Sphk1 Cct6b Cct5 Cct3 Cct4 Cct2 Cct7 DRUG ADME%REACTOME DATABASE ID RELEASE 97%10228908 Drug ADME Sult2a1 Sult2a6 Ces2h Adh1 Xdh Itpa Nt5c2 Akr1c3l1 Rac1 Vav3 Abcg2 Abcc1 Cyp2c66 Cyp2c11 Cyp2e1 Vav2 Akr1c1 Akr1c9 Akr1c12l1 Slc29a3 Slc28a3 Impdh2 Slc28a2 Impdh1 Slc29a1 Gmps Slc16a1 Nme2 Nme1 Cyp3a9 Pon3 Pon1 Slco1b2 Slco2b1 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Abcb1 Slco1a4 Abcc3 Abcc4 Abcc2 Abcc5 Alb Cyp2d4 Glyat Serpina6 Hsd11b1 Hsd11b2 Slc22a2 Slc22a1 Slc22a3 Pnp Gsta5 Adk Hprt1 Ugt1a1 Ada Glyatl3 Vav1 Bche Ugt1a6 Ugt1a7 Ces1d Ugt1a8 Acsm2 Bsg Acsm4 Acsm5 Sult1a1 Slc22a7 AC114845.1 Ugt2b7 Slc29a2 Ugt2a1 Ugt2a3 Ugt2b1 Gstp1 Gsta6 Gsta3 Acy1a Gsta1 Gsta2 Ugt3a1 Sult1e1 Ggt1 Ugt2b34l1 Ugt2b Akr1c18 Ugt2b17 Akr1c19 Ugt2b15 Gstt1 Akr1c21 Cndp2 Ggt5 Ggt7 Ggt6 Tpmt Nat1 Nat2 Nat3 Ugt2b37 Akr1c12 Akr1c13 Sult2a2 TRP CHANNELS%REACTOME DATABASE ID RELEASE 97%10230770 TRP channels Trpm3 Trpc4ap Trpm6 Trpv5 Trpv4 Trpc5 Trpc7 Trpv6 Trpc1 Trpc4 Trpc3 Trpm2 Trpm1 Mcoln3 Trpm8 Trpa1 Trpm7 Trpv1 Trpv3 Mcoln1 Mcoln2 Trpv2 Trpm4 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229388 Pregnenolone biosynthesis Cyp11a1 Fdxr Fdx2 Tspoap1 Stard4 Tspo Stard6 Akr1b1 Star Fdx1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 97%10229274 APC-Cdc20 mediated degradation of Nek2A Anapc16 Ube2d1 Anapc15 Anapc5 Bub1b Anapc4 Anapc1 Anapc2 Anapc7 Rps27a Ube2e1 Cdc16 Ubb Ubc Uba52 Ube2s Cdc20 Ube2c Nek2l1 Cdc27 Cdc26 Mad2l1 Cdc23 Anapc10 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-RNO-2467813.1 Separation of Sister Chromatids Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Psma4 Nup160 Psma3 Psma6 Psma5 Psma2 Psma1 Nup85 Dync1li2 Nup43 Dync1li1 Psmd12 Psmd11 Xpo1 Ranbp2 Psmd14 Psmd13 Ppp2r5b Ppp2r5a Nup133 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Psma7 Psmc5 Itgb3bp Psmc2 Psmc1 Psmc4 Espl1 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Psmd1 Adrm1 Hdac8 Pafah1b1 Cdca5 Zw10 Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Pttg1 Rps27 Clip1 Kif18a Dync1h1 Plk1 Dync1i2 Dync1i1 Rps27a Nudc Sec13 Clasp1 Clasp2 Ppp2cb Spc24 Ppp2ca Birc5 Uba52 Spc25 Ercc6l Ube2s Nuf2 Rangap1 Cdc20 Ube2c Cdca8 Cdc27 Incenp Cdc26 Knl1 Cdc23 Mad2l1 Ndel1 Anapc10 Sgo2 Anapc16 Sgo1 Anapc15 Bub1b Anapc5 Anapc4 Ckap5 Anapc1 Aurkb Anapc2 Cenpc Cenpa Anapc7 Spdl1 Pmf1 Ube2e1 Ska2 Cdc16 Ska1 Ahctf1 Ppp2r5d Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Ubb Taok1 Nde1 Ubc Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Psmb6l1 Nup98 Zwilch GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%10231776 GBP-mediated host defense Gbp5 Gbp2 Actg1 Gbp1 Gbp3 Actb Fnta Fntb Sfn Pggt1b Furin Pim1 Casp1 S PHASE%REACTOME%R-RNO-69242.1 S Phase Pold3 Cdc25a Ccnh Ccnd1 Cdk4 Cdk7 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Psmd12 Pole4 Psmd11 Orc5 Orc4 Orc6 Psmd14 Orc1 Psmd13 Orc3 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Rpa1 Rpa2 Psmb7 Cdc6 Psmb6 Psmb1 Prim2 Rpa3 Cdk2 Psmb3 Psmb2 Prim1 Mcm3 Mcm4 Mcm5 Psma7 Pole Mcm2 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ptk6 Cdkn1b Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Psmd1 Adrm1 Esco1 Cdca5 Esco2 Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Cables1 Cdc25b Skp2 Rb1 Akt3 Akt2 Akt1 Gins2 Gins1 Gins4 Gins3 Dna2 Rps27a Skp1 Uba52 Ube2s Ccne1 Ccne2 Ube2c Cdc27 Cdc26 Ccna1 Cdc23 Ccna2 Cks1b Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Fen1 Lig1 Anapc2 Fzr1 Anapc7 Ube2e1 Pold1 Cdc16 Pold4 Ubb Mnat1 Ubc Wee1 Rbx1 Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Psmb6l1 Rfc2 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10231246 Lipid particle organization Cidea Fitm2 Cidec Fitm1 Hsd17b13 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation Hspa8 Fkbp4 Hspb8 Hsp90aa1 Ptges3 Rptor Akt1s1 Hspa2 Ep300 Cryab Dnajb1 Hsbp1 Crebbp Camk2a Mtor Hsp90ab1 Hspa1b Hspa1a Camk2g Mlst8 Camk2d Camk2b Hspa1l Hsf1 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%10229528 MDK and PTN in ALK signaling Ptn Alk Mdk Ptprz1 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%10228930 Conjugation of salicylate with glycine Glyat Glyatl3 Acsm2 Acsm4 Acsm5 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 97%10229864 Beta-oxidation of very long chain fatty acids Mlycd Slc27a2 Acox1 Ehhadh Acaa1b Acot4 Acot8 Eci2 Abcd1 Hsd17b4 Decr2 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230866 Glycosphingolipid transport Arf1 GLTP Esyt3 Cptp Esyt2 Cln3 Plekha8 Esyt1 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events Prkaca Prkacb Nefl Grin2a Gria1 Camk4 Prkar1a Gria4 Camk2a Gria3 Prkar1b Grin3a Calm3 Gria2 Grin2d Grin2c Rps6ka3 Grin1 Rps6ka1 Prkar2a Rps6ka2 Dlg1 Dlg2 Dlg3 Lrrc7 Dlg4 Grin2b Actn2 Rps6ka6 Camk1 Camk2g Camk2d Camk2b Camkk1 Camkk2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856828.1 Clathrin-mediated endocytosis Arfgap1 Cops5 Syt2 Tor1b Syt1 Ldlrap1 Syt9 Syt8 Eps15 Egfr Picalm Scarb2 Dnajc6 Ldlr Ocrl Stam2 Dab2 Clta Ubqln2 Rab5a Cltc Dnm1 Necap1 Chrm2 Vamp8 Ubqln1 Epn2 Dvl2 Epn1 Cops3 Dnm3 Cops4 Cops6 Dnm2 Rab5c Fnbp1 Gak Synj1 Arpc3 Hip1r Cops2 Arpc2 Sh3gl2 M6pr Cops8 Arrb1 Egf Snx9 Arpc5 Reps1 Ttgn1 Aak1 Reps2 Igf2r Arpc4 Cd3g Synj2 Syt11 Cd3d Slc2a8 Cd4 Tfrc Ap2m1 Sh3gl3 Pik3c2a Hspa8 Sh3kbp1 Sh3gl1 Fnbp1l Grk2 Lrp2 Arrb2 Fcho1 Fcho2 Ereg Grb2 Cftr Necap2 Actr2 Avpr2 Btc Actr3 Arpc1a Stam Slc18a3 Agfg1 Itsn1 Cops7a Apob Bin1 Gapvd1 Cops7b Hip1 Itsn2 Vamp7 Vamp2 Tf Fzd4 Tgfa Rab5b Snx18 Avp Hbegf Cltb Rps27a Ap2b1 Agtr1 Pacsin1 Vamp3 Areg Pacsin3 Uba52 Vamp4 Pacsin2 Nedd8 Arf6 Wnt5a Adrb2 Gps1 Ston1 Ston2 Ubb Ap2a2 Ap2a1 Ubc Ap2s1 Hgs Eps15l1 Tacr1 Il7r Trip10 Pip5k1c Cbl Grk3 Tor1a Amph Snap91 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%10230240 O-linked glycosylation Pofut3 Pofut4 Thsd4 Cfp Spon2 Spon1 Sspo B3glct Muc19 B3gnt9 B3gnt8 B3gnt6 Muc15 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 B3gnt3 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts15 Galnt3 Adamts16 Adamts17 Adamts18 Adamts19 Adamts10 Sbspon Pomt1 A4gnt B3galnt2 Adamts12 Pomt2 Muc5b Pomk Muc4 Pomgnt2 Muc6 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt1 Galnt9 Galnt2 Adamts20 Thsd7b Sema5a B3gnt5 Chst10 B3gnt7 B3gnt2 St6gal1 B4galt5 B4galt6 St3gal4 St3gal2 St3gal3 B4gat1 St3gal1 Adamts3 Adamts2 Adamts14 Slc35a1 Adamts5 Adamts4 Thbs1 St6galnac3 Muc13 St6galnac2 Mgat5b Mmrn1 Fkrp Slc35a4 Qtgal Rxylt1 Adamts1 Crppa Dag1 Adamts9 Adamts8 Thbs2 Large1 Adamts7 Large2 Pomgnt1 Adamts6 Pofut2 Fktn Thsd1 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-RNO-181431.1 Acetylcholine binding and downstream events Chrnb2 Chrne Chrng Chrna4 Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrnb3 Chrna9 Chrnb4 Chrna3 Chrnd PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 97%10228386 Pyrimidine salvage Upp1 Upp2 Pudp Dck Tk2 Uck1 Uck2 Tymp Cda ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 97%10230456 Acyl chain remodeling of DAG and TAG Pnpla3 Dgat1 Pnpla2 Mgll Dgat2l6 Dgat2 Awat2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-RNO-8939236.1 RUNX1 regulates transcription of genes involved in differentiation of HSCs Ccnh Cdk7 Kmt2a Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cbfb Runx1 Itch Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Abl1 Psmd1 Adrm1 Lmo2 Lmo3 Gata1 Gata2 Uba52 Tp73 Tcf3 Tal1 Yap1 Tcf12 Mnat1 Ubb Ubc Gata3 Psmb6l1 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-RNO-9851695.1 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes Ccnc Tbl1x H2bc6 H2bc4 Hist1h4m H2bc1 Rb1 Med30 Abl1 Med31 H2ac18 Ppargc1a Ppargc1b Ajuba Hist1h2ai Crebbp Sirt1 Hdac3 Hist1h2bq Tbl1xr1 Ncoa2 Cdk5 Med23 Med24 Med20 Ncor2 Ep300 Med27 H2aj Gps2 Med12 H2ab2 Med1 H3-3b Med13 Hist3h2ba Ncoa3 Med14 H2ac4 Med10 Med4 Pparg Med6 Rxra H2bc18 Med16 Med17 H2az2 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%10228922 Metabolism of steroids Srebf1 Cyp24a1 Cubn Kpnb1 Ldlrap1 Osbpl1a Akr1c3l1 Lbr Akr1c1 Tspo Akr1c9 Gc Hsd17b12 Akr1c12l1 Ran Slco1b2 Tspoap1 Hsd17b3 Lrp2 Mbtps1 Pomc Ch25h Akr1b1 Amacr Star Hsd17b4 Osbpl3 Slco1a4 Osbpl2 Osbpl7 Osbpl6 Baat Osbpl9 Hsd3b7 Abcc3 Scp2 Stard4 Akr1d1 Slc10a1 Stard6 Acox2 Fabp6 Stard5 Acot8 Alb Osbp Lgmn Slc27a5 Slc51a Slc27a2 Slc51b Abcb11 Lhb Scap Hsd3b Cyp17a1 Hsd3b6 Serpina6 Abcd3 Hsd3b5 Hsd3b1 Hsd3b5-ps1 Hsd11b1 Hsd11b2 Srd5a3 Srd5a1 Srd5a2 Cga Sts Vdr Cyp39a1 Cyp19a1 Ncoa2 Cyp11a1 Cyp51a1 Cyp8b1 Cyp7b1 Nr1h4 Cyp21 Cyp46a1 Cyp27a1 Pias4 Cyp11b1 Fdx1 Ube2i Cyp11b3 Cyp11b2 Fdxr Fdx2 Cyp7a1 Cyp27b1 Akr1b10 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Akr1c18 Akr1c19 Akr1c21 Plpp6 Fdps Idi1 Hsd17b7 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Acat2 Nsdhl Dhcr24 Sumo3 Rxra Dhcr7 Akr1c12 Lss Srebf2 Akr1c13 Tm7sf2 Pmvk Hmgcr Mvd Msmo1 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228414 Ligand-dependent caspase activation Tlr4 Ticam2 Cd14 Traf2 Ticam1 Fadd Ripk1 Casp8 Tradd Ly96 Fas Cflar Faslg Tnfsf10 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 97%10231580 Inactivation of CSF3 (G-CSF) signaling Csf3 Ube2d1 Tyk2 Jak2 Syk Rps27a Ube2d2 Lyn Hck Socs1 Socs3 Ubb Cul5 Ubc Eloc Elob Uba52 Ube2d3 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 97%10228566 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Acadvl Hadha Hadhb CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 97%10229886 Chaperonin-mediated protein folding Csnk2b Gnb2 Pdcl Gnb1 Sphk1 Cct6b Cct3 Gnb4 Rgs7 Gnb3 Cct2 Gnb5 Cct7 Rgs9 Tcp1 Csnk2a2 Cct8 Cct6a Csnk2a1 Cct5 Cct4 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 97%10231274 MET activates PTPN11 Met Grb2 Gab1 Hgf Ptpn11 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-RNO-196780.1 Biotin transport and metabolism Mccc2 Slc5a6 Pcca Hlcs Pccb Btd Acacb Mccc1 Acaca Pc PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Pik3ca Fgf9 Klb Fgf19 Fgfr4 Pik3r1 Grb2 Gab1 Frs2 Ptpn11 Fgf16 Fgf17 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%10230332 Downstream signaling events of B Cell Receptor (BCR) Nfkbia Cul1 Psma4 Psma3 Psma6 Chuk Psma5 Psma2 Psma1 Nfatc3 Psmd12 Nfatc2 Psmd11 Rasgrp1 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Fkbp1a Psmc2 Prkcb Psmc1 Psmc4 Psmc3 Psmd7 Ikbkb Psmd6 Psmd8 Psmd2 Ikbkg Rps27a Ppp3ca Ppp3cb Psmd1 Adrm1 Bcl10 Nfkb1 Nfkbie Nfatc1 Ppp3r1 Skp1 Rel Calm3 Uba52 Fbxw11 Rela Malt1 Btrc Nras Ubb Ubc Kras Hras Nfkbib Psmb6l1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 97%10231542 Transcriptional Regulation by NPAS4 Bmal1 Maged1 Npas4 Arnt2 Arnt SIGNALING BY NTRK2 (TRKB)%REACTOME%R-RNO-9006115.1 Signaling by NTRK2 (TRKB) Plcg1 Dock3 Grb2 Fyn Sos1 Ntf4 Ntrk2 Frs2 Bdnf Rac1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-RNO-388841.1 Costimulation by the CD28 family Prkag1 Cd28 Prkag2 Ost4 Cops5 Ccnd1 Tmem258b Ppp2r1b Tusc3 Ppp2r1a Cdk4 Kmt2a Cul1 Kmt2c Cd86 H2ac18 Cd80 Cul3 Ezh2 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Mapkap1 Psma1 B3gnt3 Csnk2a2 Dad1 Csnk2a1 Ywhag Trib3 Psmd12 Psmd11 Suz12 Pdpk1 Hist1h2bq Rac1 Psmd14 Psmd13 Ppp2r5b Wdr5 Ppp2r5a Ash2l Ddost Psmb5 Psmb4 Csnk2b Psmb7 Them4 Psmb6 Psmb1 Ppp2r5e Eed Psmb3 Psmb2 Gsk3b Lyn Cd274 Yes1 H2aj Os9 Src Psma7 H3-3b Psmc5 RT1-Db2 Hist3h2ba Psmc2 Cd247 Psmc1 Cd3g RT1-Db1 Psmc4 Mtor Pak1 Psmc3 Cd3e Pdcd1 Cd3d Trav19 Rnf5 AC109737.1 Mlst8 Sel1l Cd4 H2bc18 RT1-Ha Nek2l1 Lck Magt1 Icoslg Psmd7 RT1-Ba Pik3r5 Pak2 Psmd6 RT1-Bb Pik3r6 H2az2 Grap2 ENSRNOG00000065955 Pik3cg Psmd8 Icos Trbv16 Psmd2 RT1-Da H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Mib2 Psmd1 Pdcd1lg2 Adrm1 Prkab2 Hist1h2ai Prkab1 Grb2 Fyn Csk Akt3 Akt2 Akt1 Pak3 Cdc42 Vav1 Pik3r1 Pik3r2 Pik3r3 Map3k8 Rps27a Skp1 Ppp2cb Ppp2ca Uba52 Ctla4 Map3k14 Btla Btrc Pik3cb Pik3cd Pik3ca Ppp2r5d H2ab2 Rnf185 Prkaa1 Derl3 Ubb Prr5 Derl2 H2ac4 Ubc Stt3b Rbx1 Rictor Erlin2 Spop Erlin1 Ptpn6 Vcp Rpn2 Ptpn11 Rpn1 Ostc Prkag3 Psmb6l1 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Metabolism of amine-derived hormones Txndc11 Aanat Duoxa1 Tph2 Duoxa2 Slc5a5 Ddc Tph1 Pnmt Iyd Asmt Tshb Cga Dio1 Dio2 Duox1 Dbh Dio3 Th Cav1 Duox2 Tpo XENOBIOTICS%REACTOME DATABASE ID RELEASE 97%10228540 Xenobiotics Cyp3a9 Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Cyp2s1 Cyp2c24 Arnt Ahr Ahrr Cyp2j16 Cyp2c66 Cyp2c11 Cyp2e1 Cyp2j3 Cyp1a1 Cyp2f2 Cyp1a2 Cyp2w1 Cyp2b1 Arnt2 Cyp2a2 Cyp2a1 Cyp2d4 Cyp2a3 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 Max Chek1 Rbbp4 Bmi1 Yaf2 Eed Rbbp7 Pcgf2 Rnf2 L3mbtl2 Ezh2 Mga E2f6 Pcgf6 Ring1 Epc1 Cbx3 Suz12 Phc1 Tfdp2 Tfdp1 Ehmt1 Phc3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10228794 Extracellular matrix organization P4hb Madcam1 Vcam1 Ncan Vcan Bmp10 Dtna Dtnb Sspn Bmp2 Gdf5 Ddr2 Eln Adam12 Fbln2 Fbln5 Ddr1 Drp2 Sntg2 Comp Sdc4 Utrn Sdc3 Efemp2 Itga1 Itga10 Bmp7 Ibsp Itgae Itgad Sgcz Snta1 Mfap4 Mfap5 Mfap2 Sntb2 Agrn Sntb1 Sgce Sgcd Sgcb Sgca Sgcg Col4a1 Col4a2 Itga7 Tnc Itgax Itga8 Dmp1 Itga9 Dspp Vtn Tnn Itga2 Tnr Tnxb Itgb6 Hapln1 Serpine1 Gpr162 Col14a1 Pxdn Col10a1 Jam3 Ppib Col1a2 Jam2 Col3a1 Col28a1 Col22a1 Fn1 Col5a2 Col5a3 Adamts3 Fgb Col24a1 Fga Adamts2 Col5a1 Fgg Col9a2 Itga2b Col9a3 Lox Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 Adamts14 P3h1 Crtap Pcolce2 Colgalt2 Loxl2 Loxl1 Megf11 Lama4 Loxl4 Loxl3 Col2a1 Col27a1 Col4a4 Col6a2 Serpinh1 Col23a1 Col6a5 Col6a6 Col4a5 Col6a3 Col8a1 Col4a6 Col8a2 Bmp1 Plod3 Tll2 Tll1 Plod1 Plod2 Thbs1 Cd47 F11r Ctsb Ctsd Pecam1 Ctsk Ctsl Ctss Itgav Dag1 Itgb3 Mmp7 Mmp3 Itga6 Itga3 Col7a1 Prkca Itgb1 Fgf2 Mmp2 Mmp9 Adam19 Lum Tgfb1 Tgfb2 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Acan Itgb8 Sdc1 Itgb4 Sdc2 Cdh1 Ctsg Nid2 Bmp4 Fbn1 Ceacam1 Mmp24 Mmp25 Col18a1 Adam15 Optc Adam10 Bsg Htra1 ENSRNOG00000069479 Mmp20 Mmp11 Col26a1 Mmp12 Mmp13 Mmp14 Adamts5 Mmp15 Adamts4 Mmp16 Mmp17 Mmp19 Adam8 Mmp8 Dcn Try10 Dmd Prss2l1 Ctrb1 Mmp10 Capn15 Cast Col15a1 Col13a1 Plg Klkb1 Col19a1 Elane Bcan Phykpl Spp1 Furin Cma1 Try5 Cd44 LOC102554637 Scube3 Capn9 Capn8 Itga4 Scube1 Capn5 Capn7 Itgal Capn6 Itgb7 Col25a1 Capn1 Timp1 Itgb2 Capn3 Capn2 Timp2 Prss2 Prss3 Tmprss6 Mmp1b Tpsb2 Prss1 Spock3 Icam1 Capns1 Icam5 Capn10 Icam4 A2m Icam2 Capn11 Capn12 Capn13 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%10229230 Chylomicron clearance Ldlr Lipc Ldlrap1 Apoe Apob DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%10229250 Downstream signaling of activated FGFR4 Gab1 Frs2 Frs3 Shc1 Fgf16 Fgf17 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 IRON UPTAKE AND TRANSPORT%REACTOME%R-RNO-917937.1 Iron uptake and transport Cul1 Fbxl5 Ftl1 Steap3 Fth1 Atp6v0b Aco1 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v0a1 Abcg2 Hmox1 Atp6v1c2 Hmox2 Atp6v1c1 Atp6v0c Lcn2 Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Tf Atp6v1a Atp6v1b2 Atp6v0d2 Fth1-ps5 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Tfrc Slc46a1 Rps27a Slc40a1 Cp Skp1 Uba52 Cybrd1 Mcoln1 Cand1 Ftmt Slc22a17 Nedd8 Slc11a2 Ireb2 Heph Ubb Ubc Hfe Steap4 Tfr2 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-RNO-427589.1 Type II Na+ Pi cotransporters Slc34a1 Slc34a2 Slc34a3 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by AKT (PKB) Tsc1 Akt1 Akt3 Akt2 Tsc2 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors Chrm4 Hrh2 Hrh3 Drd2 Drd3 Drd4 Drd5 Taar6 Adra2a Taar9 Adra2c Adra2b Taar3 Taar2 Taar5 Taar1 Gpr143 Htr4 Chrm2 Adrb1 Adra1b Adrb3 Htr6 Adra1a Adra1d Htr7 Taar8c Adrb2 Htr2a Htr2c Htr2b Htr5a Htr1d Htr1f Chrm1 Hrh1 Chrm3 Chrm5 Htr1b Hrh4 Htr1a OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 97%10229356 Oligomerization of connexins into connexons Gjb1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-RNO-425397.1 Transport of vitamins, nucleosides, and related molecules Slc29a2 Arl2 Slc25a4 Slc27a1 Lcn12 Lcn9 Arl2bp Vegp2 Vegp1 Slc33a1 Slc27a4 Slc25a5 Apod Slc28a1 Slc27a6 Slc29a4 Slc35d2 Slc35c1 Slc29a3 Slc35d1 Slc28a3 Slc35b4 Slc28a2 Slc35a3 Slc29a1 Slc35a2 Slc35b3 Slc5a6 Slc35a1 Slc35b2 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%10230744 SUMOylation of nuclear envelope proteins Ube2i Sumo1 Rangap1 ERKS ARE INACTIVATED%REACTOME%R-RNO-202670.1 ERKs are inactivated Mapk7 Mapk1 Ppp2r1b Ppp2r1a Mapk3 Ppp2r5d Dusp3 Dusp4 Ppp2cb Ppp2ca Dusp7 Dusp6 Vrk3 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 97%10228306 Mitochondrial Fatty Acid Beta-Oxidation Acot1 Them5 Acot2 Pcca Acadvl Acot5 Acot3 Pccb Mcat Acad11 Eci1 Acaa2 Acot9 Acbd6 Acot7 Acadm Echs1 Acsf2 Dbi Mmaa Them4 Ndufab1 Pctp Decr1 Acot11 Acot12 Acot13 Acads Mmut Mecr Hadha Hadhb Acadl Hadh PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Kl Fgfr1 Fgf10 Fgf3 Fgf22 Fgf17 SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL Smad2 Smad3 Mapk1 Mapk3 Smad4 Foxo3 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-RNO-9033658.1 Blood group systems biosynthesis St3gal6 St3gal4 B3galt5 St3gal3 Abo2 St6galnac6 B3galt4 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt1 LIPOPROTEIN METABOLISM%REACTOME%R-RNO-174824.1 Lipoprotein metabolism Npc1 Pcsk9 Apoc4 Vldlr P4hb Hdlbp Cubn Ldlrap1 Angptl8 Lmf1 Lmf2 Lpl Angptl4 Angptl3 Abca1 Mttp Ldlr Apoc2 Lcat Lipg Lipc Apoc3 Clta Apoa2 Zdhhc8 Apoe Cltc Apoa4 Pcsk5 Apoa5 Pcsk6 Apob Pltp Bmp1 Ap2m1 Gpihbp1 Sar1b Prkaca Rps27a Prkacb Ap2b1 Uba52 Furin Apoa1 Alb Ubb Nr1h3 Ap2a2 Nr1h2 Ap2a1 Ubc Ap2s1 Nceh1 Apobr A2m Amn Soat2 Apoc1 Soat1 Lipa Mylip Scarb1 Npc2 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%10230402 Phase 4 - resting membrane potential Kcnk10 Kcnj14 Kcnk16 Kcnk18 Kcnk4 Kcnk2 Kcnk1 Kcnk12 Kcnk15 Kcnk5 Kcnj2 Kcnj4 Kcnk9 Kcnk7 Kcnk13 Kcnk6 Kcnj12 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%10230218 Advanced glycosylation endproduct receptor signaling Ager Hmgb1-ps34 Hmgb1l2 Hmgb1l1 App S100b Capza1 Capza2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10228184 RNA Polymerase II Transcription Rad50 Prkag1 Prkag2 Ccnd1 Kmt2a Kmt2c H2ac18 Topbp1 Rbbp8 Ezh2 Psma4 Psma3 Brca1 Psma6 Cited2 Mta2 Psma5 Ywhae Psma2 Mbd3 Psma1 Rad1 Eloc Bnip3l Csnk2a2 Elob Steap3 LOC134478826 Csnk2a1 Ywhag Psmd12 Psmd11 Chd3 Suz12 Gatad2a Hist1h2bq Gatad2b Ctnnb1 Psmd14 Psmd13 Wdr5 Ash2l Atxn3 Foxg1 Psmb5 Foxo6 Psmb4 Foxo4 Csnk2b Foxo1 Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 H2aj Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Ppm1a Tgif1 Tgif2 H2bc18 Ski Sp1 Tfdp2 Psmd7 Tfdp1 Smad4 Psmd6 Ccnk Ube2d3 H2az2 Atp1b4 Psmd8 Ccnc Psmd2 Ube2d1 Trim33 Rnf111 H2bc6 Rbbp5 Smurf2 Smad2 Rbbp4 Smurf1 Smad3 H2bc4 Wwtr1 Usp9x Hist1h4m Ccnt2 H2bc1 Rbbp7 Rbl1 E2f4 Smad7 Psmd1 E2f5 Skil Adrm1 Kat2a Smyd2 Prkab2 Maml3 Hist1h2ai Rbpj Prkab1 Hdac5 Hdac4 Maml1 Maml2 Hdac11 Hdac10 Notch3 Hdac9 Hdac8 Prdm9 Ehmt1 Cdc73 Pcgf2 Cox7a2l Cox6a1 Cox6a2 Hdac2 Hdac1 Kmt5a Higd1c Coxfa4 Cox6c2 Sirt1 Cycsl2 Cox6b1 Cox8a Cox6b2 Cox8c Brpf3 Cox7b Cox4i1 Cox4i2 Mt-co3 Cox7c Mt-co2 Cycs Rnf34 Cox7a1 Cox7a2 Sgk1 Cox5a Cox5b Mt-co1 Ppara Cdk5r1 Nek4 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Prr5 Nr1h3 Tfap2c Polr2i Nr1h2 Taf9b Polr2j Gpi Tfap2b Taf15 Rictor Rxrb Taf11 Rxra Taf10 Taf13 Taf12 Snrpf Gtf2h2 Gtf2h1 Pgr Gtf2f2 Gata3 Gtf2f1 Rxrg Gtf2h3 Gtf2h5 Snrpg Tbp Snrpb Tbl1x Ercc2 Ccnh Ercc3 Taf4b Pip4k2b Taf7l-ps1 Pip4k2c Gtf2a1 Pip4k2a Cdk7 Prmt5 Gtf2a2 Cited1 Gtf2b Taf8 Taf7 Taf6 Esr1 Taf5 Esr2 Taf4 Gtf2e1 Cdk9 Taf2 Mapkap1 Crebbp Taf1 Gtf2e2 Hdac3 Pou2f1 Pdpk1 Snrpd3 Prmt1 Tbl1xr1 Rara Foxo3 Ppard Snrpepl2 Tp53 Lamtor5 Rptor Ncor2 Lamtor3 Rraga Lamtor4 Ep300 RragB Src Lamtor1 Rragc Lamtor2 Kat2b Rragd Rarg Mtor Rheb Cdkn1b Mlst8 Slc38a9 Nr5a2 Foxp3 Bax Sympk Clp1 Pip4p1 Ywhaq Ywhah Ywhab Sfn Pcf11 Lhb Cstf1 Nudt21 Cstf2 Prmt6 Cstf3 Slbp Actl6b Aurka Tgfb1 Cga Vdr Men1 Arnt Srrt Nr1h4 Phf20 Arnt2 Med1 Fip1l1 Pparg Papola Prdx1 Setd1b Cpsf4 Cpsf6 Setd1a Cpsf7 Cpsf1 Cpsf2 Cpsf3 Kmt2d Kmt2b Furin Snapc3 Snapc4 Snapc1 Snapc2 Sesn2 Sesn1 Ramac Myc Zfp839 Ddit4 Cited4 Zfp819 Cstf2t Phax Ell2 Smarca4 Ell3 Cdk13 Cdk12 Ell Pabpn1 Ywhaz Ing5 Ing2 Zik1 Ptpn11 Brd1 Zfp867 Zfp866 Mecp2 Zfp612 Cdc25c Zim1 Zfp617 Tfap2a Npm1 Gls Zfp605 Atad2 Eloa Zfp46 Zfp804b Rnmt Rprd1a Rprd1b Supt6h Zfp418l1 Sesn3 Tfap2e Brpf1 Npas4 Tp53rkb Tp53rka Zfp52 Kat6a Znf354c Znf354b Znf354a Zfp90 Zfp78 Zfp74 Maged1 LOC102546572 Zfp81 Mllt3 Skic8 Mllt1 Ints4 Ints5 Ints6 Ssrp1 Zfp398 Ctr9 Ints7 Paf1 Ints8 Ints9 Ints1 Ints2 Ints3 Zfp386 Zfp764l1 Rffl Zfp133 Txn Znf382 Cradd Pidd1 Znf394 Tpx2 Tmem219 Tp63 Gsr Banp Nabp1 Nabp2 Esrra Esrrb Zfp273l-ps1 Esrrg Gpx2 Zfp180 Zfp189 Zfp184 Ccng1 Zfp169 LOC102547287 Nr5a1 Zfp94l1 LOC108348267 Zfp455l1 Zfp790 Zfp317 Zfp799 Zfp300 Zfp786 Zfp788 Rsl1 Nr3c2 Wwox Nr3c1 Zfp770 Znf773 Zfp775 Tead3 Yeats4 Tead2 Cbx3 Tbx5 Zfp764 Tead4 Cnot3 Zfp763 Cnot2 Jmy Plk3 Nr4a1 Zfp111 Btg2 Zfp113 Cnot1 Zfp597 Cnot7 Znf750 Plk2 Zfp599 Cnot6 Nr1d2 Cnot11 Nr1d1 Tnks1bp1 Zfp583 Cnot4 Zfp101 Cnot9 Ar Cnot8 Cnot6l Cnot10 Dyrk2 Cpap Trim28 Iws1 Thrb Thra Dek Znf740 Zfp566 Zfp324 LOC120095871 Nr1i3 Nr1i2 Zfp954 Zfp951 Zfp790l2 Zfp710 Zfp952 Znf18 Zfp719 Prdx2 Prdx5 Mapkapk5 Zfp704 Zfp945 Zfp703 Zfp706 Zfp948 ENSRNOG00000070049 Krabd3 L3mbtl2 L3mbtl1 Akt3 Daxx Akt2 Nrbf2 Nrbf2l1 Zfp758 Akt1 Zscan25 Zscan22 Pou2f2 Zfp746 Pcgf6 Noc2l Txnrd1 Tcf7 Tigar Tcf7l1 Zfp964 Hipk1 Zfp286a Rabggta Rabggtb Ppp1r13l Ppp1r13b Zfp119bl Max Rorc Rorb Gls2 Stk11 Ints13 Ints14 Ints11 Ints12 Leo1 Ints10 Zc3h8 Rprd2 G6pdx Ccnb1 Mga Zfp37-ps1 Rngtt E2f6 E2f7 E2f8 Zfp275 Cdk1 Epc1 Zfp1 Elf1 Cbfb Zfp266 Zfp263 Runx1 LOC120101823 Nr6a1 Itch Zfp496 Zfp808l3 Eaf1 Eaf2 Zfp483 Rpap2 Zfp248 Nuak1 Chm Usp2 Hnf4a Mapk1 Hnf4g Zkscan8 Tcf7l2 Zkscan7 Rps27a Zkscan1 Zkscan4 Zkscan5 Mapk3 Sirt3 Zkscan3 Nr4a3 Nr4a2 Zfp955a Zfp955b Bmal1 Lmo2 Nrif1 Lmo3 Lef1 Serpinb13 Runx3 Zfpm1 Zfp12 Gata1 Ppp2cb Zfp13 Gata2 Ppp2ca Zfp950l16 Uba52 Zfp282 Ring1 Tp73 Ttc5 Eloa2l Ccnd2 Phc2 Nr2c2 Ccne1 Nr2c1 Ccne2 Cbx6 Ice2 Ccnd3 Phc1 Kctd1 Pou4f1 Cbx4 Znf431l2 Cbx2 Phc3 Pou4f2 Cdk6 Zfp668 Znf689 Tcf3 Sin3a Zfp664 Sin3b ENSRNOG00000065205 Bmi1 Zfp658 Yaf2 Zfp655 Pax5 Ssu72 Znf624l Elf2 Tal1 Zfp641 Yap1 Zfp647 Rnf2 Pcgf5 Znf667 Tcf12 Znf426 Pml Aff4 Map2k6 Meaf6 Nr2f6 Nr0b2 Ctsk Nr0b1 Mdm4 Ctsl Ubb Nr2f1 Zfp385a Nr2e3 Ubc Gadd45a Exo1 Zfp212 Igfbp3 Rfc5 Zfp213 Zfp455 Rfc3 Mapk14 Rex2l4 Rfc4 Pcna Zfp445 Rfc2 Zfp688 Zfp950l5 Ppp2r1b Ppp2r1a Lsm10 Pbrm1 Lsm11 Nelfa Smarcd1 Nelfb Smarcb1 Zfp473 Nelfe Smarcd3 Mapk11 Ctdp1 Smarcd2 Ncbp2 Ncbp1 Supt4h1 Nelfcd Brd7 Arid1a Arid1b Lbr Actl6a Rpa1 Rpa2 Smarce1 Smarcc1 Smarca2 Rpa3 Cdk2 Casp2 Usp7 Tcea1 Cdk5 Chd4 Mre11 Ube2i Kat5 Nbn Hus1 Atrip Dna2 Blm Kdm5b Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Abl1 Rad17 Atm Atr Ccna1 Ccna2 Aurkb Rmi2 Parp1 Rmi1 Brip1 Tsc2 H2ab2 Tsc1 Prkaa1 Sumo1 H2ac4 Rhno1 Wrn Prkag3 Psmb6l1 AGGREPHAGY%REACTOME%R-RNO-9646399.1 Aggrephagy Dynll1 Dynll2 Prkn Rps27a Dync1h1 Park7 Ube2n Ubb Cftr Ubc Pcnt Uba52 Dync1li2 Dync1i2 Arl13b Dync1li1 Dync1i1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism Dcakd Ppcdc Coasy Pank3 Pank2 Aasdhppt Pank4 Pank1 Fasn Slc25a16 Slc25a42 Slc5a6 Ppcs Vnn1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity Trim33 Ube2d1 Smad2 Smurf2 Mapk1 Smad3 Usp9x Rps27a Ncor2 Mapk3 Parp1 Skil Hdac1 Ubb Ubc Uba52 Ppm1a Tgif1 Tgif2 Ski Smad4 Ube2d3 Atp1b4 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape Gtf2h5 Tbp Ercc2 H2bc6 Ccnh Ercc3 H2bc4 Hist1h4m H2bc1 Cdk7 Taf1d H2ac18 Rrn3 Taf1a Taf1c Taf1b Hist1h2ai Polr1b Polr1c Polr1a Polr1f Polr1g Polr1e Polr1h Cbx3 Ubtf Hist1h2bq Phf6 H2aj H2ab2 Polr2h Polr2e H3-3b Polr2f Hist3h2ba Mnat1 H2ac4 H2bc18 Gtf2h2 Gtf2h1 Gtf2h3 H2az2 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) Psmd8 Psmd2 Ccnd1 Cdk4 Rps27a Psmd1 Cul3 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Csnk2a2 Uba52 Csnk2a1 Ywhag Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Cd274 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Spop Psmd7 Psmd6 Psmb6l1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) Vps37c Chmp2b Vps37d Vps36 Rps27a Vps4a Vps4b Stam Stam2 Uba52 Chmp3 Vps25 Chmp5 Vps28 Chmp4c Chmp7 Chmp6 Ubap1 Tsg101 Snf8 Ubb Chmp4bl1 Mvb12a Ubc Hgs Mvb12b Vps37a Chmp2a Vps37b RAF ACTIVATION%REACTOME%R-RNO-5673000.1 RAF activation Ppp2r1b Raf1 Jak2 Ppp2r1a Ppp1cb Camk2a Ppp2cb Calm3 Ppp2ca Mark3 Braf Ppp2r5b Map2k1 Ppp2r5a Ppp2r5e Ppp2r5d Ywhab Src Ksr1 Brap Phb1 Araf Shoc2 Ppp1cc Nras Mras Map3k11 Kras Hras Camk2g Map2k2 Camk2d Camk2b TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%10231134 TP53 Regulates Transcription of Death Receptors and Ligands Igfbp3 Tmem219 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-RNO-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands Ccl9 Anxa1 Fpr2l1 Hebp1 Fpr1 App Ccl6 Fpr2l3 Fpr2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 97%10229918 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Plxna4 Plxna3 Fyn Plxna2 Sema3a Plxna1 Pip5k1c Tln1 Farp2 Nrp1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230380 SHC1 events in ERBB2 signaling Hbegf Btc Prkcd Egfr Prkca Erbb2 Ereg Egf Erbb3 Nrg2 Nrg1 Nrg3 Shc1 Prkce Ptpn12 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-RNO-9006335.1 Signaling by Erythropoietin Pik3cg Pik3cb Jak2 Rapgef1 Pik3cd Pik3ca Vav1 Lyn Pik3r1 Irs2 Grb2 Epo Epor Gab1 Shc1 Pik3r5 Crkl GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-RNO-202433.1 Generation of second messenger molecules ENSRNOG00000065955 Trbv16 RT1-Da Lat Fyb1 Itk Pak3 Plcg1 Plcg2 Lcp2 Zap70 Cd101 RT1-Db2 Cd247 Cd3g Pak1 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Nck1 RT1-Ba Pak2 RT1-Bb Grap2 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10229342 Gap junction trafficking Gja1 Cltb Gja3 Gja5 Gja4 Gja10 Gja8 Dab2 Clta Gjd2 Cltc Gjd4 Dnm1 Gjd3 Dnm2 Gjc1 Gjc2 Myo6 Gjb2 Gjb1 Gjb4 Gjb3 Ap2m1 Gjb6 Gjb5 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230936 Cilium Assembly Dynll1 Dynll2 Kif3a Smo Kif3b Ppp2r1a Kif3c Ywhae Ywhag Gmnn Kifap3 Pcnt Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Tfdp1 Ift74 Dynlrb2 Ift56 Dynlrb1 Ift70a2 Dynlt5 Ift70b Dynlt2 Kif17 Ift20 Prkaca Ift43 Ift22 E2f4 Ift81 E2f5 Ift27 Cluap1 Nphp4 Cep97 Ift46 Csnk1d Dync2i1 Cep192 Dync2li1 Ift25 Dync2i2 Dynlt2b Rpgrip1l Ift80 Cep78 Traf3ip1 Cep76 Tmem67 Cep72 Fbf1 Cep70 Plk4 Cep89 Cep83 Cep57 Ift140 Tmem216 Unc119b C2cd3 Cep63 Mark4 Alms1 Septin2 Kif24 Ttbk2 Cep43 Mks1 Tctn3 Cep41 Ift52 Tctn1 Tctn2 Ninl B9d1 Ttc21b Atat1 Cc2d2a Tubb5 Arl3 Odf2 Ift57 Iqcb1 Haus7 Ahi1 Haus8 Nphp3 Haus4 Nphp1 Haus5 Rp2 Ift122 Haus6 Sstr3 Cpap Ofd1 Cep162 Haus1 Sclt1 Pafah1b1 Wdr35 Cngb1 Dync2h1 Nedd1 Ift172 Wdr19 Inpp5e Arl13b Pde6d Pcm1 Grhl3 Gmnc Mcidas Ssna1 Grhl2 Actr1a Tubg1 Grhl1 Akap9 Sfi1 Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Cep152 Rab11a Cep290 Cep164 Ccp110 Dync1h1 Plk1 Exoc3 Tnpo1 Exoc4 Exoc5 Mchr1 Exoc6 Cdk1 Exoc1 Dync1i2 Exoc2 Exoc7 Arf4 Exoc8 Thoc2l Rab3ip Cnga4 Pkd1 Cnga2 Asap1 Csnk1e Gbf1 Clasp1 Rab8a Tp73 Ckap5 Hsp90aa1 Cct3 Rho Bbs2 Mapre1 Cct2 Bbs10 Mkks B9d2 Bbs12 Arl6 Ttc8 Tcp1 Lztfl1 Nde1 Bbip1 Bbs7 Cct8 Bbs5 Trip11 Bbs4 Cct5 Cct4 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-RNO-196854.1 Metabolism of vitamins and cofactors Rdh11 Cubn Ldlrap1 Ubiad1 Shmt1 Nt5e Mccc1 Lpl Mccc2 Apoc2 Akr1c3l1 Apoc3 Apoa2 Aco1 Apoe Vkorc1 Apoa4 Shmt2 Mtrr Nampt Abcc1 Pdxk Naxe Akr1c1 Slc52a2 Akr1c9 Slc52a3 Lrpl1 Btd Acacb Slc25a51 Acaca Aasdhppt Akr1c12l1 Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Cblif Tcn2 Fpgs Coq2 Mmut Mthfs Mthfr Slc25a32 Idh1 Slc46a1 Slc23a1 Mthfd1l Slc23a2 Naprt Mmadhc Slc2a1 Gsto1 Pcca Slc2a3 Gsto2 Rfk Lrp1 Sdc4 Dcakd Sdc3 Pccb Acp5 Lrp8 Lrp10 Aox1 Plb1 Ppcdc Lrp12 Coasy Ttpa Nadk2 Ttr Nudt12 Gpc1 Mthfd2l Gpc3 Nmrk1 Gpc2 Cyb5a Bco2 Mocs3 Gpc4 Slc25a16 Bco1 Ppcs Gpc6 Agrn Calm3 Hlcs Clps Aldh1l1 Pnlip Aldh1l2 Rbp4 Cd38 Lrp2 Apom Nadsyn1 Rbp2 Pnpo Rbp1 Nadk Lrat Cyb5r3 Nmnat1 Mmaa Flad1 Mmab Rnls Enpp1 Mocs1 Mmachc Slc22a13 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Mthfd2 Apoa1 Gphn Pank3 Pank2 Pank4 Mocos Nos3 Pank1 Prkg2 Gpc5 Spr Gch1 Pts Gchfr Pdss2 Coq8a Coq8b Pdss1 Coq3 Coq4 Coq5 Akt1 Coq6 Mtr Hpdl Coq7 Coq9 Stard7 Sdc1 Sdc2 Apob Gpihbp1 Slc25a19 Thtpa Akr1b10 Tpk1 Slc19a2 Slc19a3 Nfs1 Folr2 Bst1 Vnn1 Akr1c18 Akr1c19 Hsp90aa1 Akr1c21 Vkorc1l1 Amn Akr1c12 Akr1c13 Pc GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-RNO-9762114.1 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Psmd8 Psmd2 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Nfe2l2 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Gsk3b Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Psmd7 Psmd6 Psmb6l1 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%10228154 Switching of origins to a post-replicative state Skp2 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Mcm7 Mcm8 Psmd12 Psmd11 Orc5 Orc4 Psmd14 Orc6 Psmd13 Orc1 Orc3 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Psmb7 Psmb6 Cdc6 Psmb1 Psmb3 Cdk2 Psmb2 Mcm3 Mcm4 Mcm5 Psma7 Mcm2 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ube2s Ccne1 Ccne2 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Rbx1 Psmb6l1 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%10229504 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Cd40 Tnfsf13b Cd40lg Tnfsf11 Traf2 Traf3 Birc2 Tnfsf14 Tnfsf12 Tnfrsf11a Tnfrsf13c Tnfrsf12a Lta Ltb Ltbr Map3k14 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%10228576 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Slbp Lsm11 Zfp473 Snrpg Snrpb Ncbp2 Snrpepl2 Ncbp1 Snrpf Snrpd3 Lsm10 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter Polr3e Tbp Polr3b Brf1 Polr3c Polr3f Polr3g Gtf3c2 Polr3gl Gtf3c1 Crcp Gtf3c4 Bdp1 Gtf3c3 Gtf3c6 Gtf3c5 Polr2h Polr2e Polr2f Gtf3a Polr1c Polr3a Polr3d SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation Irs2 Grb2 Mapk1 Sos1 Ins1 Insr Ins2 Mapk3 Shc1 Grb10 Irs1 CELL DIVISION%REACTOME DATABASE ID RELEASE 97%10228870 cell division Pds5b Stag2 Kif23 Stag1 Pds5a Smc1a Smc3 Kif20a Wapl Nipbl Mau2 Plk1 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival Nfkbia Traf6 Rps27a Ngfr Nfkb1 Ubb Sqstm1 Ubc Uba52 Ngf Rela Ikbkb Irak1 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors Oxtr Avpr1b Avpr1a Avp Avpr2 Oxt C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 97%10228594 C6 deamination of adenosine Adarb1 Adar HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors Lhcgr Gpha2 Tshr Lhb Tshb Gnrh1 Fshb Fshr Cga Gnrhr KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis Fmod St3gal6 St3gal4 St3gal2 Lum St3gal3 B4gat1 Omd St3gal1 Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan B3gnt3 Chst6 Ogn Slc35d2 B3gnt7 B3gnt2 Kera B4galt4 B4galt5 B4galt6 Prelp CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB1 phosphorylation through the activation of Adenylate Cyclase Prkar1a Prkar2a Prkar1b Prkaca Prkacb AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 97%10228840 Amine Oxidase reactions Smox Maoa Maob SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%10229902 Signal amplification P2ry12 Aamp Gnai2 Gnai1 Gna13 P2ry1 Gnai3 Gna11 Gna14 Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Gnat3 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Src Gng12 Pla2g4a Tbxa2r Gng10-ps1 Mapk14 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-RNO-6804760.1 Regulation of TP53 Activity through Methylation Chek2 Tp53 Rps27a Prmt5 L3mbtl1 Ep300 Smyd2 Kmt5a Ubb Mdm4 Ubc Uba52 Ttc5 Atm Jmy Ehmt1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%10229590 Antigen Presentation: Folding, assembly and peptide loading of class I MHC Sar1b RT1-M1-5 Rt1-ec3 Sec13 Erap1 Hspa5 RT1-M6-2 AABR07044308.1 B2m Pdia3 Sec31a Tap2 Tap1 RT1-M10-ps5 Sec24d Calr Sec24c RT1-N3 RT1-M5 Sec24b Sec24a Sec23a RT1-M2 Canx Tapbp O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-RNO-5173214.1 O-glycosylation of TSR domain-containing proteins Thsd4 Cfp Spon2 Adamts5 Spon1 Sspo Adamts4 Thbs1 B3glct Adamts3 Adamts2 Sema5b Adamts14 Adamts13 Adamts15 Sema5a Adamts16 Adamts17 Adamts18 Adamts19 Adamts10 Sbspon Adamts12 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Adamts20 Adamts1 Thsd7b Adamts9 Adamts8 Thbs2 Adamts7 Adamts6 Pofut2 Thsd1 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%10229184 Phosphorylation of the APC C Anapc16 Ube2d1 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ccnb1 Plk1 Cdk1 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis Dmc1 Fignl1 Firrm Rad51 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 97%10231242 Reelin signalling pathway Sh3kbp1 Dab1 Vldlr Fyn Reln PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1963642.1 PI3K events in ERBB2 signaling Hbegf Btc Pik3ca Egfr Pik3r1 Erbb2 Ereg Egf Grb2 Erbb3 Gab1 Nrg2 Nrg1 Nrg3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-RNO-173736.1 Alternative complement activation C3 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins Pard6a Psmd8 Psmd2 Smurf2 Smurf1 Rps27a Fzd3 Psmd1 Fzd7 Adrm1 Psma4 Fzd8 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Prickle1 Psmd12 Psmd11 Psmd14 Psmd13 Dvl2 Psmb5 Psmb4 Fzd1 Psmb7 Fzd2 Wnt5a Psmb6 Fzd5 Psmb1 Psmb3 Psmb2 Fzd4 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-RNO-1296065.1 Inwardly rectifying K+ channels Kcnj14 Kcnj15 Kcnj16 Kcnj3 Kcnj2 Gng3 Gng5 Kcnj1 Gng4 Gng7 Abcc8 Gng8 Gngt1 Gnb2 Gnb1 Gabbr1 Gnb4 Kcnj8 Gnb3 Gnb5 Abcc9 Gng11 Gabbr2 Gng12 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gng10-ps1 Kcnj11 Kcnj10 Kcnj12 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 97%10229602 Regulation of KIT signaling Kit Lyn Yes1 Src Prkca Grb2 Fyn Kitlg Sos1 Ptpn6 Cbl Sh2b2 Lck INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%10230204 Inflammasomes Bcl2l1 P2rx7 Panx1 Pycard Txnip Sugt1 Txn Nlrp3 Mefv Nlrp1a Hsp90ab1 Pstpip1 Aim2 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-RNO-6787450.1 tRNA modification in the mitochondrion Yrdc PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Pik3ca Fgf9 Pik3r1 Grb2 Kl Gab1 Fgfr1 Frs2 Fgf10 Fgf3 Fgf22 Ptpn11 Fgf17 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-RNO-5666185.1 RHO GTPases Activate Rhotekin and Rhophilins Lin7b Rtkn Rhpn1 Rhpn2 Rhoa SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-RNO-9955298.1 SLC-mediated transport of organic anions Slc44a1 Avp Slc44a2 Slc17a5 Slc25a10 Slco1b2 Slc44a3 Slco2b1 Slc44a4 Slc44a5 Slco3a1 Slco4a1 Slco2a1 Slc5a7 Slco4c1 Slco1c1 SLC16A2 Slc25a1 Slc5a12 Slco1a4 Slc16a3 Slc16a8 Slc10a6 Slc5a8 Slc16a1 Slc13a5 Slc22a12 Bsg Emb Slc22a6 Slc16a7 Slc13a3 Slc22a8 Slc13a2 Slc25a11 Slc22a7 PI3K CASCADE%REACTOME%R-RNO-109704.1 PI3K Cascade Akt2 Irs1 Irs2 Kl Gab1 Flt3 Fgf10 Frs2 Trib3 Fgf3 Fgf22 Fgf7 Pdpk1 Pik3c3 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Them4 Pik3cb Fgfr2 Pde3b Fgf6 Pik3r4 Fgf5 Fgf8 Gab2 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Pik3r1 Pik3r2 Fgfr3 Tlr9 Grb2 Fgfr1 Ptpn11 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10231276 VLDL assembly Mttp Apoc4 P4hb Apoc1 Apob TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids Slc27a1 Lcn12 Lcn9 Vegp2 Vegp1 Slc27a4 Apod Slc27a6 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction Nck2 Bcar1 Rapgef1 Stat3 Pdgfrb Stat1 Pdgfra Stat5a Stat5b Rasa1 Stat6 Grb7 Plcg1 Pik3cb Pik3ca Src Pik3r1 Pik3r2 Nras Grb2 Kras Sos1 Crk Hras Pdgfa Pdgfb Ptpn11 Nck1 Crkl NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230174 Nucleosome assembly Cenpl Cenpk H2bc6 Cenpi Cenph Npm1 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 H2ac18 Hist1h2ai Ruvbl1 Hist1h2bq Knl1 Cenpc Cenpa H2aj H2ab2 Rsf1 Smarca5 Oip5 Hist3h2ba Mis18a Itgb3bp Cenpw H2ac4 Mis18bp1 Hjurp Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm H2az2 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex Rbbp5 Tcf7l2 Rps27a Sox3 Ctbp1 Sox9 Sox7 Hdac1 Sox6 Pygo2 Akt2 Sox4 Tle1 Pygo1 Tle4 Kmt2b Lef1 Akt1 Tle2 Uba52 Tcf7 Xiap Sox13 Tcf7l1 Xpo1 Sox17 Bcl9l Men1 Bcl9 Ctnnb1 LOC134484451 Cby1 Wdr5 Ash2l Btrc Apc Chd8 Sry Ctnnbip1 Ubb Tle3 Ubc Ywhaz SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%10229432 Signaling by WNT Csnk1a1 Cul3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Csnk2a2 Csnk2a1 Clta Cltc Psmd12 Psmd11 Lrp6 Ctnnb1 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Wdr5 Ash2l Dvl1 Dvl3 Psmb5 Wnt1 Amer1 Psmb4 Fzd1 Csnk2b Fzd2 Psmb7 Fzd5 Psmb6 Psmb1 Ppp2r5e Apc Axin1 Psmb3 Psmb2 Wnt8b Wnt8a Gsk3b Frat2 Frat1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Smurf2 Rbbp5 Smurf1 Psmd1 Adrm1 Arrb2 Cdc73 Kras Dkk4 Kremen2 Kremen1 Sost Dkk1 Dkk2 Sox3 Sox9 Ctbp1 Sox7 Ctbp2 Sox6 Hdac1 Pygo2 Akt2 Sox4 Tle1 Pygo1 Tle4 Akt1 Tle2 Tnks2 Hecw1 Klhl12 Axin2 Rnf43 Tcf7 Sox13 Tcf7l1 Sox17 Bcl9l Bcl9 LOC134484451 Rnf146 Cby1 Znrf3 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Dact1 Sry Leo1 Ryk Ctnnbip1 Fzd4 Lgr5 Lgr6 Pip5k1b Prkcb Wnt11 Vps26a Vps35 Tmed5 Pde6g Wnt6 Pard6a Wnt2b Vps29 Daam1 Snx3 Ror1 Wnt5b Ror2 Pfn1 Wnt9a Wnt7a Gnao1 Nlk Wnt9b Csnk1e Wnt10a Tcf7l2 Cltb Rps27a Wnt2 Ppp3ca Fzd3 Map3k7 Wnt4 Ppp3cb Wnt16 Wls Fzd7 Wnt10b Fzd6 Fzd8 Rac2 Rac3 Nfatc1 Lef1 Ppp3r1 Skp1 Camk2a Ppp2cb Gnat2 Ppp2ca Pde6a Uba52 Cav1 Pde6b Prickle1 Btrc Ppp2r5d Tle3 Ubb Ap2s1 Ubc Ppp2r1b Ppp2r1a Cul1 Crebbp Xpo1 Rac1 Dvl2 Ep300 Rhoa Gng10-ps1 Ap2m1 Prkcg Prkca Calm3 Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Zranb1 Men1 Ap2b1 Kmt2b Xiap Wnt5a Ap2a2 Ap2a1 Smarca4 Rbx1 Ywhaz Psmb6l1 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 97%10230734 SUMO E3 ligases SUMOylate target proteins Nfkbia Rad52 Nup58 Npm1 Nup37 Nup205 Pom121 Nup107 Nup188 Tpr Pias3 Nup160 Esr1 Sumo2 Brca1 Ikbke Mta1 Rae1 Ndc1 Vhl Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Suz12 Nup214 Ranbp2 Rara Nup155 Nup133 Nup210 Nup153 Rpa1 Ep300 Nr5a2 Hist1h4m Park7 Nr5a1 Hdac4 Mrtfa Nr3c2 Nr3c1 Ar Pcgf2 Trim28 Hnrnpc Thrb Thra Stag2 Stag1 Hnrnpk Smc1a Smc3 Trim27 Nr1i2 Smc6 Smc5 Sp140 Nsmce4a Hic1 Eid3 Nsmce1 Nsmce2 Safb Zfp131 Sp3 Ddx17 Mageb10 Sp100 Hdac2 Mbd1 Cetn2 Casp8ap2 L3mbtl2 Ctbp1 Top2b Uhrf2 Top2a Daxx Hdac1 Top1 Vdr Satb2 Nr1h4 Dnmt1 Pias4 Ube2i Pias2 Xpc Blm Pias1 Ikbkg Sec13 Nfkb2 Ppara Birc5 Ring1 Xrcc4 Rangap1 Phc2 Rela Cdca8 Phc1 Incenp Cbx4 Satb1 Cbx2 Phc3 Tp53bp1 Sin3a Nrip1 Bmi1 Aurkb Parp1 Rnf2 Mitf Nop58 Pml Herc2 Tdg Nr1h3 Tfap2c Rnf168 Nr1h2 Sumo1 Sumo3 Rxra Nup93 Nup50 Ing2 Nup35 Pcna Pgr Nup54 Nup98 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed Senp2 Sumo1 Sumo3 Senp1 Senp5 Senp5l1 Sumo2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%10230334 Activation of RAS in B cells Nras Kras Hras Rasgrp1 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%10228764 Pyroptosis Chmp2b Hmgb1l2 Hmgb1l1 Il1a Il1b Gsdme Hmgb1-ps34 Chmp4bl1 Gsdmd Bax Cycsl2 Chmp3 Elane Gzmb Chmp4c Bak1 Cycs Chmp7 Casp3 Il18 Casp1 Chmp6 Chmp2a FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-5661270.1 Formation of xylulose-5-phosphate Akr1a1 Dcxr Xylb Sord Cryl1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin Ttll5 Ttll10 Ttll2 Ttll3 Ttll11 Ttll12 Ttll8 Ttll13 Ttll9 Ttll6 Ttll7 Ttll4 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 97%10231484 TYSND1 cleaves peroxisomal proteins Tysnd1 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism Slc44a1 Lpgat1 Slc44a2 Pip4k2b Pip4k2c Pip4k2a Pitpnb Pik3c2b Liph Lipi Mtmr7 Mtmr6 Arf1 Ocrl Mtmr9 Mfsd2a Csnk2a2 Csnk2a1 Gpat4 Rab5a Gpat3 Rab4a Pik3c3 Rufy1 Pnpla6 Pnpla3 Enpp6 Csnk2b Pnpla2 Tafazzin Agk Synj1 Pik3r4 Pip5k1a Pld1 Pcyt1b Pcyt1a Abhd3 Cds2 Gnpat Tnfaip8l2 Mtmr14 Tnfaip8l3 Pla2g4a Tnfaip8l1 Pgp Synj2 Inpp5k Mtmr3 Pik3c2a Pik3r5 Awat2 Pik3r6 Pik3cg Acp6 Crls1 Ddhd2 Plb1 Agpat4 Agpat1 Agpat2 Slc44a3 Slc44a4 Dgat2 Slc44a5 Gpam Gde1 Dgat1 Cds1 Gpat2 Mtmr1 Cpne1 Cpne3 Cpne6 Cpne7 Pemt Rab14 Pcyt2 Etnk2 Cept1 Pip4p1 Etnk1 Pitpnm2 Etnppl Pld2 Pitpnm3 Chka Agpat3 Pitpnm1 Chkb Selenoi Phospho1 Inpp5j Plekha8 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Lpcat1 Inpp5e Pi4kb Pi4ka Pik3c2g Tpte2 Sacm1l Lpcat2 Mgll Miga2 Pla2g15 Miga1 Gpd2 Gpd1 Pld6 Stard7 Inpp5f Dgat2l6 Pi4k2b Inpp4a Pikfyve Inpp4b Mtm1 Chat Fig4 Vac14 Mtmr12 Mtmr4 Pi4k2a Alpi Tmem86b Cdipt Lclat1 Chpt1 Pctp Stard10 Tnfaip8 Pik3r1 Pik3r2 Pik3r3 Lpin3 Pip5k1b Lpin2 Inppl1 Arf3 Pla2g6 Bmx Pla2g4f Pla2g2d Pla2g2f Ptpn13 Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Inpp5d Pla2g4b Pla2g12a Mboat7 Lpcat3 Pla2g10 Lpcat4 Abhd4 Plaat3 Pnpla8 Pla2g5 Plaat1 Pla2g3 Plaat5 Mboat1 Mboat2 Pik3cb Pik3cd Sbf1 Pik3ca Osbpl5 Pten Pla1a Osbpl8 Osbpl10 Pip5k1c Ptdss1 Hadha Ptdss2 Hadhb Gpd1l PROTEIN HYDROXYLATION%REACTOME%R-RNO-9629569.1 Protein hydroxylation Jmjd7 Jmjd6 Rpl27a Rps6 Etf1 Riox2 Ogfod1 Rps23 Riox1 Kdm8 Rpl8 Rccd1 Jmjd4 Drg1 Zc3h15 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230832 SUMOylation of DNA replication proteins Nup58 Nup37 Nup205 Pom121 Nup107 Nup188 Top2b Top2a Tpr Top1 Pias3 Sumo2 Nup160 Rae1 Ndc1 Nup85 Birc5 Nup42 Nup62 Nup43 Rangap1 Nup88 Aaas Cdca8 Incenp Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Aurkb Pias4 Ube2i Sumo1 Sumo3 Nup93 Nup50 Nup35 Pcna Nup54 Nup98 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 97%10228650 Base-Excision Repair, AP Site Formation H2bc6 Neil3 H2bc4 Hist1h4m H2bc1 H2ac18 Hist1h2ai Hist1h2bq Terf2 Terf1 Tinf2 Acd Terf2ip Pot1 H2aj Mbd4 H2ab2 Smug1 Mpg Tdg Hist3h2ba Nthl1 Ogg1 Ung H2ac4 Mutyh Neil2 Neil1 H2az2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228320 Phenylalanine and tyrosine metabolism Gstz1 Hpd Fah Il4i1 Pcbd1 Pah Kyat1 Hgd Tat Asrgl1 Qdpr MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%10231302 MET activates STAT3 Met Stat3 Hgf SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10229998 Small interfering RNA (siRNA) biogenesis Ago3 Tsn Ago2 Ago1 Dicer1 Tarbp2 Tsnax Ago4 Prkra HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230872 Hedgehog ligand biogenesis P4hb Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Os9 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Sel1l Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Ihh Uba52 Dhh Disp2 Scube2 Hhat Shh Ubb Derl2 Gpc5 Ubc Notum Syvn1 Vcp Psmb6l1 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%10231626 Regulation of Expression and Function of Type I Classical Cadherins Ost4 Tmem258b Cbll1 H2ac18 Eps15 Ezh2 Psma4 Psma3 Psma6 Jup Psma5 Psma2 Psma1 Csnk2a2 Dad1 Ctnnd1 Csnk2a1 Psmd12 Psmd11 Suz12 Pcsk6 Hist1h2bq Ctnnb1 Psmd14 Psmd13 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Pomt1 H2aj Arhgap32 Pomt2 Src Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Banp Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Psmd1 Adrm1 Hist1h2ai Mogs Prkcsh Mtbp Pcsk7 Fyn Ganab Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Cdh1 Ctnna1 Sec11c Canx Sec11a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Uba52 Furin Vcl Ctsb H2ab2 Ubb Ctsl H2ac4 Ubc Ctss Smarca4 Pip5k1c Rpn2 Rpn1 Ostc Psmb6l1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%R-RNO-2142691.1 Synthesis of Leukotrienes (LT) and Eoxins (EX) Ggt1 Alox5 Lta4h Alox15 Abcc1 Cyp4f39 Dpep1 Dpep2 Cyp4f1 Cyp4a14 Ltc4s Cyp4f3 Cyp4f40 Cyp4a12 Ggt5 Cyp4b1 Cyp4f4 Cyp4a10 Cyp4a2 Mapkapk2 Alox5ap ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway RT1-M10-ps5 AABR07044308.1 RT1-M2 B2m RT1-M1-5 Rt1-ec3 Lnpep RT1-N3 RT1-M5 RT1-M6-2 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME DATABASE ID RELEASE 97%10231404 Noncanonical activation of NOTCH3 Psen2 Ncstn Ybx1 Aph1a Aph1b Notch3 Psenen Psen1 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport Actr1a Arfgap3 Copa Dynll1 Arfgap2 Dynll2 Arfgap1 Ank1 Gorasp1 Dctn1 Dctn2 Tmem115 Copb2 Dctn4 Rab1b Arf1 Copb1 Cope Dync1li2 Dync1li1 Napa Golgb1 Bet1l Kdelr2 Gosr1 Kdelr3 Gosr2 Dync1h1 Tmed9 Dync1i2 Kdelr1 Dync1i1 Arf4 Arf3 Tmed10 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Rab1A Copz2 Cd59 Cd55 Copz1 Folr1 Arf5 Spta1 Golga2 Bet1 Ins1 Ins2 Nsf Uso1 Sptbn1 Sptb Napb Actr10 Sptbn2 Sptan1 Stx5 Sptbn5 Sptbn4 Napg Ykt6 Cog1 Cog2 Cog3 Cog4 Cog5 Cog6 Arcn1 Cog7 Cog8 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%10230148 AUF1 (hnRNP D0) binds and destabilizes mRNA Psmd8 Hspa8 Psmd2 Hspb1 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Hspa1b Hspa1a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Hnrnpd Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Pabpc1 Psmb6l1 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME DATABASE ID RELEASE 97%10230812 EPH-ephrin mediated repulsion of cells Efnb1 Efnb2 Mmp2 Efnb3 Mmp9 Vav2 Psenen Lyn Yes1 Src Psen1 Psen2 Ncstn Fyn Aph1a Aph1b Ephb1 Ephb2 Ephb3 Ephb4 Rac1 Tiam1 Ephb6 Vav3 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229384 Mineralocorticoid biosynthesis Hsd3b Cyp11b3 Hsd3b6 Hsd3b5 Hsd3b1 Hsd3b5-ps1 Lhb Cyp21 Cga TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Slc28a3 Slc29a2 Slc28a2 Slc29a1 Arl2bp Arl2 Slc25a4 Slc25a5 Slc28a1 Slc29a4 Slc29a3 VITAMINS%REACTOME%R-RNO-211916.1 Vitamins Cyp24a1 Cyp26b1 Cyp26c1 Cyp27b1 Cyp26a1 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism Glb1l3 Glb1l2 Ctsa St3gal2 Hexa Hexb Arsa St3gal3 Smpd2 St6galnac5 Smpd3 Ugt8 St6galnac6 Smpd4 Smpd1 Gba1 Gba3 Gba2 Enpp7 B3galt4 Neu2 Galc Asah2 Fut2 Glb1 Fut1 Neu3 Asah1 Neu4 Sts Gm2a Neu1 Arsl Arsk A4galt St8sia5 Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 St3gal5 M6pr B3galnt1 B4galnt1 Gal3st1 Cerk B3gnt5 Psap Glb1l Ugcg B4galt5 B4galt6 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-RNO-75105.1 Fatty acyl-CoA biosynthesis Hacd2 Cbr4 Hacd3 Hacd4 Tecr Acsbg1 Acsbg2 Ppt2 Ppt1 Hsd17b8 Hsd17b3 Acsf3 Morc2 Scd1 Hsd17b12 Acaca Fasn Slc27a2 Acsl3 Acsl4 Acsl1 Elovl2 Acly Elovl3 Acsl5 Elovl5 Acsl6 Elovl1 Elovl6 Elovl7 Tecrl Hacd1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%10228348 Cytosolic tRNA aminoacylation Ppa1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%10228640 Formation of Incision Complex in GG-NER Gtf2h5 Rad23b Ercc2 Rnf111 Ube2v2 Ccnh Ercc1 Ercc3 Ercc4 Rps27a Cdk7 Cetn2 Ube2n Pias3 Sumo2 Uba52 Usp45 Rpa1 Rpa2 Ddb1 Cul4a Parp2 Rpa3 Parp1 Xpa Cul4b Ddb2 Ube2i Chd1l Mnat1 Ubb Sumo1 Ubc Rbx1 Sumo3 Xpc Rad23a Gtf2h2 Gtf2h1 Gtf2h3 Pias1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%10228302 Citric acid cycle (TCA cycle) Suclg2 Fxn Cs Fh Nfs1 AC132020.1 Idh2 Iscu Sirt3 Sdhaf1 Sdhaf2 Sdhaf3 Mdh2 Aco2 Idh3B Kgd4 Lyrm4 Idh3g Idh3a Ogdh Sdhd Nnt Sdhc Sdhb Sdha Isca2 Acat1 Isca1 Dld Sucla2 Trap1 Dlst Suclg1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-RNO-888590.1 GABA synthesis, release, reuptake and degradation Hspa8 Gad1 Gad2 Syt1 Slc6a1 Aldh5a1 Vamp2 Stxbp1 Slc6a11 Slc6a13 Slc6a12 Dnajc5 Abat Cplx1 Rims1 Stx1a Rab3a Snap25 Slc32a1 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes Cdc25c Npm1 Aurka Bax Ccne1 Ccne2 Ccna1 Cnot3 Ccna2 Cnot2 Plk3 Btg2 Cnot1 Cnot7 Plk2 Cnot6 Cnot11 Tnks1bp1 Cnot4 Cnot9 Cnot8 Cdk2 Cnot6l Cnot10 Cpap Ccnb1 Sfn E2f7 Gadd45a E2f8 Cdk1 Cdkn1b Pcna NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Ppp2cb Ppp2ca Kl Uba52 Fgf10 Frs2 Braf Fgf3 Fgf22 Mknk1 Fgf17 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Src Ubb Grb2 Ubc Fgfr1 Cbl Ptpn11 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 97%10231314 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2bc6 Setd1b Rbbp5 Setd1a H2bc4 Hist1h4m H2bc1 Kmt2a Kmt2c H2ac18 Hdac1 Kmt2d Hist1h2ai Kmt2b Zfpm1 Gata1 Hist1h2bq Prmt1 Wdr5 Ash2l Sin3a Sin3b Ep300 H2aj H2ab2 H3-3b Hist3h2ba Kat2b H2ac4 Cbfb Runx1 H2bc18 Prmt6 H2az2 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-RNO-445989.1 TAK1-dependent IKK and NF-kappa-B activation Ager Nkiras2 Nfkbia Hmgb1l2 Traf6 Hmgb1l1 Nlrx1 Ikbkg Rps27a Usp14 Map3k7 Tab3 Ube2n Tab2 Usp18 Lrrc14 Tab1 Nfkb2 Nlrc5 Nfkb1 Traf2 Chuk Uba52 Alpk1 Rela Tifa S100b Hmgb1-ps34 Ubb Ubc N4bp1 Casp8 Nfkbib Nkiras1 App Ikbkb Irak2 Irak1 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228738 Cam-PDE 1 activation Pde1b Calm3 Pde1c Pde1a PROTEIN UBIQUITINATION%REACTOME%R-RNO-8852135.1 Protein ubiquitination Pex13 Pex12 Uchl3 Ube2d2 Uba1 Cdc34 Hist1h2bq Usp5 Otulin Skic8 Ube2g2 Ctr9 Ube2g1 Paf1 Rraga Leo1 Ube2r2 Ube2d3 Ube2d1 H2bc6 Ube2v2 H2bc4 Usp9x H2bc1 Rps27a Prkdc Ube2l3 Ube2n Pex5 Bcl10 Ube2w Ube2k Pex10 Uba52 Ube2b Ube2s Usp7 Ube2a Ube2c Cdc73 Ube2t Ube2z Ube2e1 Rnf181 Ubb Shprh Ubc Rad18 Rnf152 Rnf40 Rnf20 Rnf144a Hltf Uba6 Wac Pex2 Pcna Ube2e3 Pex14 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade Pik3cg Lat Rhob Rac2 Mpig6b Clec1b Rhog Pdpk1 Fcer1g Rac1 Pdpn Vav3 Cdc42 Plcg2 Pik3cb Vav2 Syk Pik3ca Vav1 Lyn Pik3r1 Rhoa Pik3r2 Lcp2 Pik3r3 Fyn Gp6 Ptpn6 Ptpn11 Lck Pik3r5 Pik3r6 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 97%10228370 Recycling of eIF2:GDP Eif2b2 Eif2s3 Eif2b5 Eif2s2 Eif2b4 Eif2s1 Eif2b1 Eif2b3 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230576 CS-GAG biosynthesis Chst11 Chst12 Chsy1 Chsy3 Chst13 Chst15 Chpf Csgalnact2 Chst7 Chst9 Dcn Ust Chst3 Ncan Bgn Bcan Cspg5 Cspg4 Vcan NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR Ngf Ngfr RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Rhoc Nup107 Rhob Nup160 Nup85 Dync1li2 Nup43 Dync1li1 Xpo1 Rac1 Ranbp2 Diaph3 Ppp2r5b Dvl2 Ppp2r5a Dvl1 Nup133 Dvl3 Ppp2r5e Rhoa Itgb3bp Srgap2 Mrtfa Pafah1b1 Evl Zw10 Srf Fmnl1 Pfn2 Actb Scai Rps27 Clip1 Actg1 Kif18a Cdc42 Dync1h1 Fmnl2 Fmnl3 Plk1 Diaph1 Dync1i2 Dync1i1 Daam1 Pfn1 Nudc Sec13 Clasp1 Clasp2 Ppp2cb Spc24 Ppp2ca Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Ppp2r5d Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Icmt F7 Gas6 Arsa Rpl27a Etf1 Sts Ogfod1 Rps23 Riox1 Kdm8 Rccd1 Arsl Jmjd4 Arsk Arsj Drg1 Zc3h15 Arsi Jmjd7 Arsg Dhps Sumf1 Eif5a Arsb Fn3k Sumf2 Fn3krp Eif5a2 Dohh Ggcx Bglap Riox2 Jmjd6 F2 F8 Proc Tpst1 Rpl8 Tpst2 Furin F10 Proz F9 Dph5 Pros1 Dph6 Rps6 Eef2 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%10230572 Pre-NOTCH Expression and Processing Notch3 Elf3 Prkci Tmed2 NUCLEOTIDE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleotide catabolism Upp1 Upp2 Nudt9 Nudt16 Gda Nudt18 Adprm Entpd1 Nt5c Entpd2 Nt5c1a Nt5c1b Entpd5 Nt5e Entpd6 Entpd3 Nudt1 Entpd4 Xdh Entpd7 Itpa Entpd8 Dnph1 Nt5c2 Nudt5 Pnp Upb1 Samhd1 Nt5c3a Dpys Dpyd Nt5m Tymp PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 97%10231704 PDH complex synthesizes acetyl-CoA from PYR Pdhb Pdha1 Pdha2 Dlat Dld Pdhx INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex Anapc16 Ube2d1 Anapc15 Anapc5 Bub1b Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ube2s Cdc20 Ube2c Cdc27 Cdc26 Mad2l1 Cdc23 Anapc10 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME%R-RNO-73863.1 RNA Polymerase I Transcription Termination Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Cdk7 Taf1d Taf1a Taf1c Taf1b Cavin1 Polr1b Polr1c Polr1a Polr1f Polr1g Polr1e Polr1h Ubtf Polr2h Polr2e Polr2f Mnat1 Ttf1 Gtf2h2 Gtf2h1 Gtf2h3 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 97%10229562 CLEC7A (Dectin-1) signaling Nfkbia Cul1 Tab3 Ube2d2 Tab2 Psma4 Tab1 Psma3 Psma6 Uba3 Chuk Psma5 Pycard Psma2 Psma1 Cdc34 Nfatc3 Psmd12 Nfatc2 Psmd11 Pdpk1 Psmd14 Psmd13 Psmb5 Psmb4 Plcg2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Src Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Ikbkb Psmd6 Psmd8 Ube2d1 Psmd2 Traf6 Ikbkg Rps27a Ppp3ca Map3k7 Il1b Prkcd Ppp3cb Psmd1 Ube2n Adrm1 Bcl10 Nfkb2 Nfkb1 Nfatc1 Ube2m Ppp3r1 Skp1 Calm3 Uba52 Fbxw11 Rela Map3k14 Malt1 Btrc Relb Clec7a Card9 Ubb Ubc Casp8 Psmb6l1 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%10231628 Degradation of CDH1 Cbll1 Eps15 Psma4 Psma3 Psma6 Psma5 Jup Psma2 Psma1 Ctnnd1 Cdh1 Psmd12 Ctnna1 Psmd11 Ctnnb1 Psmd14 Psmd13 Psmb5 Psmb4 Dnm2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Src Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Banp Psmd7 Psmd6 Psmd8 Psmd2 Rack1 Rps27a Psmd1 Adrm1 Uba52 Ctsb Mtbp Ctsl Ubb Fyn Ctss Ubc Psmb6l1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 97%10229150 Signalling to RAS Shc2 Ralgds Shc3 Nras Grb2 Mapk11 Kras Sos1 Hras Mapkapk3 Mapk14 Shc1 Mapkapk2 METABOLISM OF COFACTORS%REACTOME%R-RNO-8978934.1 Metabolism of cofactors Hsp90aa1 Pdss2 Coq8a Coq8b Pdss1 Coq3 Coq4 Coq5 Nos3 Coq6 Akt1 Hpdl Prkg2 Coq7 Coq9 Spr Gch1 Calm3 Stard7 Pts Gchfr Aco1 Coq2 Idh1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%10230574 Regulation of innate immune responses to cytosolic DNA Tbk1 Ubb Nlrp4 Ubc Ddx41 Uba52 Sting1 Trim32 Rps27a Irf3 Dtx4 Trim21 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%10229820 Adipogenesis Pparg Hdac3 Rxra Ncor2 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10230962 RHOQ GTPase cycle Git1 Gja1 Rhoq Jup Cdc42ep2 Arhgef7 Steap3 Cdc42ep3 Iqgap3 Itsn1 Diaph3 Cdc42ep1 Cdc42 Fnbp1 Arhgap21 Ophn1 Rab7a Arhgap32 Lamtor1 Pak4 Plekhg3 Mpp7 Pak1 Srgap2 Snap23 Tfrc Arhgap17 Pak2 Stom Syde1 Arhgap26 Scrib Obscn Arhgap33 Arhgef9 Vamp3 Arhgap35 Depdc1b Cav1 Gopc Prex1 Dlc1 Wwp2 Arhgap5 Cdc42bpa Arhgap1 Cdc42ep4 Slc1a5 Cftr Trip10 Cdc42bpb Arl13b Slc4a7 Git2 Cpne8 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 97%10228998 Formation of ATP by chemiosmotic coupling Atp5mg Atp5f1b Atp5f1a Mt-atp6 Atp5po Atp5mk Atp5mc1 Atp5f1e Atp5f1d Atp5pb Atp5f1c Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Mt-atp8 Dmac2l SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%10228960 Synthesis of substrates in N-glycan biosythesis St8sia6 St3gal6 Ctsa St3gal4 St3gal2 St8sia3 Srd5a3 St3gal3 St6galnac5 St6galnac6 St3gal1 Neu2 Glb1 Neu3 Neu4 Neu1 St8sia5 St3gal5 Dpm1 Dpm2 Dpm3 Slc35c1 Cmas Slc35a1 Alg5 Gmds Gne Nus1 Pmm2 Pmm1 Nudt14 Npl Dhrsx Slc17a5 Nanp Nans St8sia1 Mpi St6galnac3 Dhdds Dolpp1 Fuom St6gal2 Dolk Nagk Gnpnat1 Amdhd2 Uap1 Fpgt Gmppa Gfpt1 Gfpt2 Pgm3 Fcsk Renbp St6galnac1 St6galnac2 Gfus St8sia4 St8sia2 St6gal1 Mvd GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230428 GRB2 events in ERBB2 signaling Erbb2 Ereg Nras Grb2 Kras Hbegf Sos1 Btc Nrg2 Hras Nrg1 Nrg3 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 97%10229386 Metabolism of steroid hormones Hsd3b Cyp17a1 Hsd3b6 Serpina6 Hsd3b5 Akr1b10 Hsd17b11 Hsd3b1 Hsd17b14 Hsd3b5-ps1 Hsd17b1 Hsd11b1 Hsd17b2 Hsd11b2 Srd5a3 Akr1b7 Srd5a1 Srd5a2 Cga Tspoap1 Hsd17b3 Sts Pomc Akr1b1 Star Cyp19a1 Cyp11a1 Stard4 Tspo Stard6 Cyp21 Hsd17b12 Cyp11b1 Fdx1 Cyp11b3 Cyp11b2 Fdxr Fdx2 Lhb SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-RNO-480985.1 Synthesis of dolichyl-phosphate-glucose Alg5 Nudt14 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-RNO-195399.1 VEGF binds to VEGFR leading to receptor dimerization Flt1 Pgf Flt4 Vegfa Vegfd Vegfc Kdr Vegfb COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229440 Coenzyme A biosynthesis Pank1 Ppcs Dcakd Ppcdc Coasy Pank3 Pank2 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%10229192 Mitotic Anaphase Cenpl Cenpk Dynll1 Cenpi Dynll2 Cenph Cenpf Ndc80 Lmna Psma4 Lmnb1 Psma3 Psma6 Psma5 Psma2 Psma1 Chmp3 Psmd12 Psmd11 Chmp7 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Chmp6 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Psma7 Psmc5 Tubal3 Psmc2 Rcc1 Psmc1 Spast Psmc4 Espl1 Psmc3 Ppp2r2a Tuba4a Tuba3b Tubb4b Tubb4a Tuba1a Psmd7 Tuba1c Psmd6 Cc2d1b Tubb2b Psmd8 Tubb2a Psmd2 Ist1 Ube2d1 Sirt2 Tuba8 Tubb6 Tubb3 Tubb1 Ran Psmd1 Adrm1 Hdac8 Rps27 Emd Ccnb2 Ccnb1 Plk1 Vrk1 Vrk2 Banf1 Cdk1 Ccnb2-ps2 Rps27a Nudc Ppp2cb Ppp2ca Uba52 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ppp2r5d Chmp4bl1 Ubb Ubc Nup93 Cenpe Nup35 Nup98 Chmp2a Chmp2b Nup37 Nup205 Ppp2r1b Kpnb1 Ppp2r1a Pom121 Nup107 Nup188 Nup160 Ndc1 Nup85 Dync1li2 Nup43 Dync1li1 Xpo1 Ranbp2 Lbr Nup155 Nup133 Ankle2 Itgb3bp Vps4a Chmp4c Tuba1b Pafah1b1 Cdca5 Zw10 Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Pttg1 Clip1 Kif18a Dync1h1 Ube2i Dync1i2 Dync1i1 Sec13 Clasp1 Clasp2 Spc24 Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Sumo1 Kntc1 Mad1l1 Cenpu Kif2a Cenpt Kif2b Cenpq Kif2c Cenpp Cenpo Cenpn Cenpm Mis12 Psmb6l1 Zwilch DUAL INCISION IN TC-NER%REACTOME DATABASE ID RELEASE 97%10231094 Dual incision in TC-NER Pold3 Gtf2h5 Ercc2 Ccnh Ercc1 Ercc3 Ercc4 Cdk7 Polk Xab2 Pole3 Pole2 Pole4 Ppie Rpa1 Rpa2 Rpa3 Prpf19 Xpa Pole Rps27a Znf830 Isy1 Aqr Uba52 Usp7 Uvssa Tcea1 Ercc6 Ddb1 Cul4a Pold1 Polr2c Polr2a Pold4 Polr2b Cul4b Polr2g Polr2h Polr2e Polr2f Mnat1 Ubb Polr2i Ubc Polr2j Rbx1 Rfc5 Pold2 Rfc3 Gtf2h2 Rfc4 Gtf2h1 Pcna Rfc1 Rfc2 Gtf2h3 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%10230400 Classical Kir channels Kcnj14 Kcnj2 Kcnj4 Kcnj12 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors Tfap2c Myc Kdm5b CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors Adm Ramp1 Calcrl Adm2 Calcb Calcr Calca Iapp Ramp3 Ramp2 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190377.1 FGFR2b ligand binding and activation Fgf2 Fgf1 Fgfr2 Fgf10 Fgfbp3 Fgfbp1 Fgf3 Fgf22 Fgf7 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%10230656 Anchoring fibril formation Bmp1 Tll2 Tll1 Col7a1 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-RNO-9754119.1 Drug-mediated inhibition of CDK4 CDK6 activity Cdk6 Ccnd1 Cdk4 Ccnd2 Ccnd3 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%10230760 Regulation of TP53 Activity through Acetylation Rbbp4 Pip4k2b Pip4k2c Rbbp7 Chd4 Pip4k2a Hdac2 Hdac1 Akt3 Akt2 Mta2 Akt1 Mbd3 Brpf1 Kat6a Brd7 Chd3 Gatad2a Gatad2b Pip4p1 Brpf3 Tp53 Ep300 Pml Map2k6 Meaf6 Ing5 Ing2 Brd1 MRNA EDITING%REACTOME DATABASE ID RELEASE 97%10228480 mRNA Editing Apobec4 Apobec2 Apobec3 A1cf Apobec1 Adarb1 Adar CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-RNO-389359.1 CD28 dependent Vav1 pathway Cd28 Cdc42 Grb2 Fyn Pak1 Cd86 Cd80 Vav1 Lck Rac1 Pak2 Pak3 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230302 Antigen processing: Ubiquitination & Proteasome degradation Lrr1 Nedd4 Rnf220 Cbll1 Fbxl21 Rnf213 Wsb1 Rnf217 Ube2d2 Cul3 Hecw2 Ccnf Psma4 Cblb Psma3 Psma6 Sh3rf1 Trim11 Psma5 Vhl Ube2l6 Psma2 Mex3c Psma1 Cul2 Cdc34 Eloc Elob Dcaf1 Rnf126 Rnf123 Psmd12 Ubac1 Psmd11 Lnpep Atg7 Rnf114 Psmd14 Rnf115 Psmd13 Hace1 Siah1 Siah2 Psmb5 Keap1 Psmb4 Dzip3 Psmb7 Psmb6 Mkrn1 Psmb1 Ube2g2 Psmb3 Ube2g1 Psmb2 Rnf138 Kbtbd7 Rnf130 Kbtbd8 Psma7 Fbxw4 Fbxw5 Psmc5 Fbxw7 Gan Psmc2 Fbxw8 Psmc1 Fbxw9 Psmc4 Psmc3 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Psmd7 Psmd6 Ube2d3 Klhl3 Psmd8 Klhl2 Psmd2 Ube2d1 Rnf111 Ube4a Smurf2 Spsb2 Smurf1 Trim9 Spsb1 Trip12 Spsb4 Mib2 Psmd1 Lrsam1 Huwe1 Ube2j2 Adrm1 Ube2j1 Kctd7 Ube2u Kctd6 Ube2w Ube2m Ube2k Rnf182 Ube2o Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Rnf41 Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 Fbxo27 Uba5 Uba6 Uba7 Trim69 Fbxw17 Trim71 Klhl25 Ube2e3 Ube2e2 Klhl21 Rnf19b Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Itch Fbxo9 Trim21 Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Rps27a Trim41 Unkl Ube2n Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 Asb1 Skp1 Lnx1 Uba52 Fbxw11 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc5 Anapc4 Anapc1 Anapc2 Btrc Fzr1 Anapc7 Wwp1 Ube2e1 Cdc16 Ubb Ubc Mylip Cul1 Ltn1 Rchy1 Skp2 Ube2v2 Prkn Ube2l3 Socs1 Socs3 Cdc20 Stub1 Herc2 Rbx1 Psmb6l1 UNWINDING OF DNA%REACTOME DATABASE ID RELEASE 97%10229238 Unwinding of DNA Gins2 Gins1 Gins4 Gins3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231430 Biosynthesis of aspirin-triggered D-series resolvins Alox5 Lta4h Gpx4 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230044 Unblocking of NMDA receptors, glutamate binding and activation Dlg1 Dlg2 Dlg3 Lrrc7 Nefl Dlg4 Grin2b Grin2a Gria1 Actn2 Gria4 Gria3 Camk2a Calm3 Gria2 Camk2g Camk2d Camk2b Grin2d Grin2c Grin1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis Abhd12 Mgll Prkcq Dgkh Dgki Dgkk Prkcd Dgkq Trpc7 Dgkz Daglb Prkch Trpc3 Itpr3 Itpr2 Dagla Dgka Dgkb Abhd6 Dgkd Itpr1 Prkce Dgke Dgkg MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%10230124 Mitochondrial tRNA aminoacylation Ppa2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 97%10228700 CaMK IV-mediated phosphorylation of CREB Camk4 Calm3 Camkk1 Camkk2 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 97%10228634 Axon guidance Rhoc Rhob Csnk2a2 Csnk2a1 Clta Gab1 Cltc Dnm1 Grb10 Dnm3 Csnk2b Dnm2 Gsk3b Sh3gl2 Limk1 Met Ranbp9 Spta1 St8sia4 Ptpra Col4a1 Col4a2 Ncam1 Sptbn1 Numb Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Sptbn4 Itga9 Nras Grb2 Fyn Kras St8sia2 Sos1 Hras Itga2b Itsn1 Tln1 Erbb2 Mapk7 Mapk1 Mapk3 Arhgap35 Crmp1 Frs2 Rdx Epha2 Grb7 Ret Rps6ka5 Plxnd1 Cdk5r1 Hsp90aa1 Dscaml1 Nrp1 Shc3 Tyrobp Dab1 Ap2s1 Hsp90ab1 Pip5k1c Itgav Pdlim7 Ntn4 Nck1 Nfasc Itgb3 Unc5a Vldlr Prkcq Ezr Egfr Sema7a Artn Lypla2 Rac1 Gfra1 Gfra2 Map2k1 Vav3 Gfra4 Plcg1 Vav2 Rras Arpc3 Shank3 Arpc2 L1cam Lyn Yes1 Src Rhoa Dpysl2 Ngef Dpysl3 Dpysl4 Arpc5 Dpysl5 Arpc4 Pak1 Map2k2 Ap2m1 Ptprc Cd72 Pak2 Plxnb1 Plxnb3 Plxna4 Sh3kbp1 Plxna3 Arhgef11 Plxna2 Arhgef12 Dok1 Prkaca Dok2 Prkacb Reln Dscam Dok4 Dok5 Dok6 Prkca Myo9b Pspn Gdnf Msn Plxnc1 Fes Nrtn Trio Itgb1 Sema6d Gap43 Cdk5 Sema5a Sema4d Sema4a Sema3a Fgfr1 Sema3e Tiam1 Farp2 Efna1 Efna2 Nck2 Git1 Sdcbp Ank1 Mmp2 Mmp9 Actr2 Epha1 Epha3 Actb Actr3 Epha4 Arpc1b Arpc1a Epha5 Psenen Arhgef28 Epha6 Epha7 Psen1 Epha10 Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Rasa1 Plxna1 Sdc2 Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Grin1 Pak3 Actg1 Cdc42 Efnb1 Efnb2 Efnb3 Rnd1 Rlc-a Rock2 Rock1 Efna4 Gab2 Efna5 Grin2b Pik3r1 Pik3r2 Pik3r3 Ap2b1 Irs2 Dcc Shc1 Rap1gap Kif4b Kif4a Pik3cb Pik3cd Pik3ca Trem2 Ap2a2 Ap2a1 Ptpn11 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin Inhba Fst Inhbb PTK6 ACTIVATES STAT3%REACTOME%R-RNO-8849474.1 PTK6 Activates STAT3 Ptk6 Stat3 Socs3 Stap2 PLC BETA MEDIATED EVENTS%REACTOME%R-RNO-112043.1 PLC beta mediated events Adcy8 Adcy5 Adcy6 Mapk1 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Grk2 Gnaq Prkar2a Pde1b Pde1c Pde1a Plcb4 Plcb3 Pla2g4a Plcb2 Plcb1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol Miox Isyna1 Ocrl Inpp1 Impa2 Synj1 Impa1 Inpp5a Inpp4a Inpp5b Inpp4b Inpp5j KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%10228402 Ketone body metabolism Hmgcs2 Acss3 Hmgcl Acat1 Aacs Bdh2 Oxct2a Bdh1 Hmgcll1 Oxct1 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%10228126 Assembly of the ORC complex at the origin of replication Orc2 H2bc6 H2bc4 Hist1h4m Kpnb1 H2bc1 Kpna6 Kpna1 H2ac18 H2aj Hist1h2ai H2ab2 H3-3b Hist3h2ba H2ac4 H2bc18 Orc5 Orc4 Hist1h2bq Orc6 Orc1 H2az2 Orc3 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Tirap Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 REGULATION OF TNFR1 SIGNALING%REACTOME%R-RNO-5357905.1 Regulation of TNFR1 signaling Otud1 Tbk1 Traf1 Ube2d1 Spata2 Rnf31 Usp2 Usp4 Ikbkg Rack1 Cyld Rps27a Otud7b Mib2 Ube2l3 Ulk1 Ube2d2 Ikbke Traf2 Chuk Birc2 Optn Fadd Uba52 Ripk1 Xiap Stub1 Otulin Tax1bp1 Clip3 Sppl2b Sppl2a Ubb Ubc Tnfrsf1a Casp8 Rbck1 Tradd Sharpin Madd Cflar Mapkapk2 Ikbkb Tnf Ube2d3 Usp21 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229826 Mitochondrial ABC transporters Abcb8 Abcb6 Abcb7 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%10229800 Centrosome maturation Actr1a Tubg1 Dynll1 Akap9 Nme7 Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Csnk1d Cep192 Tubgcp2 Clasp1 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Mzt1 Mzt2 Cep43 Cep41 Ninl Ckap5 Tubb5 Hsp90aa1 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Tubgcp3 Nde1 Cdk11b Nedd1 Pcm1 Ssna1 Tubg2 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%10229652 PRC2 methylates histones and DNA Ezhip H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 H2ac18 Ezh2 Ezh1 Hist1h2ai Aebp2 Suz12 Hist1h2bq Jarid2 Eed Dnmt1 Phf19 H2aj H2ab2 H3-3b Hist3h2ba H2ac4 Epop H2bc18 Dnmt3a H2az2 Mtf2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 97%10231556 Prednisone ADME Serpina6 Hsd11b1 Hsd11b2 Ugt2b1 Cyp3a9 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Akr1c3l1 Cyp3a1 Cyp3a62 Cyp3a2 Abcb1 Ugt2b34l1 Ugt2b Akr1c18 Ugt2b17 Akr1c19 Ugt2b15 Akr1c1 Akr1c21 Akr1c9 Alb Akr1c12l1 Ugt2b37 Akr1c12 Akr1c13 AC114845.1 Ugt2b7 G2 PHASE%REACTOME%R-RNO-68911.1 G2 Phase E2f1 E2f3 Cdk2 Ccna1 Ccna2 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%10229458 AKT phosphorylates targets in the cytosol Chuk Akt1 Casp9 Mkrn1 Akt1s1 Cdkn1b Akt3 Akt2 Tsc2 GLYCINE DEGRADATION%REACTOME%R-RNO-6783984.1 Glycine degradation Ogdh Dlst Gcsh AC132020.1 Dld Amt Kgd4 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 RNA POLYMERASE I PROMOTER OPENING%REACTOME%R-RNO-73728.1 RNA Polymerase I Promoter Opening Phf6 Mapk3 Ubtf CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition Cdc25c Cdc25b Cdc25a Ccnh Ppp2r1b Ppp2r1a Cdk7 Bora Ppp2cb Ppp2ca Ppme1 Ticrr Xpo1 Ccna1 Ccna2 Sgo1 Fzr1 Cdk2 Ccnb2 Ccnb1 Plk1 Pkmyt1 Mnat1 Mis18bp1 Wee1 Hjurp Ppp2r3b Cdk1 Ppp2r2a Ccnb2-ps2 Lcmt1 Obi1 Foxm1 SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 Hbegf Ptpn18 Btc Rps27a Prkcd Akt3 Akt2 Egfr Usp8 Prkca Akt1 Cul5 Uba52 Gab1 Shc1 Stub1 Grb7 Rnf41 Hsp90aa1 Pik3ca Yes1 Src Pik3r1 Rhoa Erbb2 Ereg Egf Nras Cdc37 Ubb Grb2 Fyn Ubc Kras Diaph1 Erbb3 Sos1 Nrg2 Hras Nrg1 Ptk6 Nrg3 Memo1 Prkce Ptpn12 Ptk7 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%10230116 Interleukin-6 family signaling Clcf1 Osm Osmr Cntf Crlf1 Tyk2 Cntfr Il6r Jak2 Stat3 Il31ra Stat1 Ctf1 Socs3 Lif Il6st Lifr Il11 Cbl Ptpn11 Il11ra1 Il6 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements Hspb1 Psma4 Psma3 Psma6 Psma5 Akt1 Psma2 Psma1 Psmd12 Psmd11 Xpo1 Nup214 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Zfp36 Psmc5 Tnpo1 Psmc2 Tnfsf13 Psmc1 Dis3 Psmc4 Psmc3 Psmd7 Psmd6 Pabpc1 Psmd8 Hspa8 Psmd2 Rps27a Prkcd Psmd1 Adrm1 Prkca Set Uba52 Anp32a Parn Hspa1b Hspa1a Exosc9 Elavl1 Exosc8 Khsrp Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Exosc3 Exosc2 Dcp2 Ywhab Dcp1a Zfp36l1 Xrn1 Ubb Hnrnpd Ubc Ywhaz Mapkapk2 Psmb6l1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 97%10229606 Regulation of thyroid hormone activity Dio1 Dio2 Dio3 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 97%10230898 Phase 3 - rapid repolarisation Kcne2 Kcna5 Akap9 Kcnh2 Kcnq1 Kcne5 Kcne4 Kcne3 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231358 RHOA GTPase cycle Jup Arhgdib Aaas Lbr Diaph3 Vav3 Pgrmc2 Arhgap21 Mcam Vav2 Atp6ap1 Ophn1 Stbd1 Pld1 Arhgdia Dock2 Vapb Arhgap32 Rhoa Ngef Plekhg3 Flot2 Flot1 Srgap1 Arhgap45 Gmip Tfrc Arhgap10 Mcf2l Bcr Arhgap4 Arhgef15 Arhgef17 Arhgef11 Arap1 Arhgef10 Arap3 Arhgef12 Arap2 Arhgef19 Akap13 Arhgap22 Arhgap9 Arhgef25 Arhgap20 Arhgef5 Arhgap26 Arhgef4 Arhgap24 Arhgef2 Arhgap29 Arhgef1 Def6 Obscn Myo9b Arhgap6 Arhgap31 Arhgap8 Arhgap30 Prex2 Abr Tagap Farp1 Ect2 Vma22 Stard8 Prex1 Trio Dlc1 Stard13 Mcf2 Arhgap40 Plekhg5 Arhgap44 Arhgap42 Net1 Rasgrf2 Slk Arhgef10l Scfd1 Tex2 Stk10 Arhgap19 Arhgap18 Cit Fam13a Arhgap28 Arhgap23 Pcdh7 Sowahc Tiam1 Plekhg6 Lman1 Pkn2 Pkn1 Faf2 Abcd3 Acbd5 Anln C1qbp Arhgef28 Arhgap11a Emc3 Myo9a Kalrn Cavin1 Arhgef7 Rtkn Rhpn1 Iqgap3 Rhpn2 Ddrgk1 Maco1 Hmox2 Rock2 Rock1 Vav1 Actc1 Fmnl3 Pik3r1 Tmem87a Pik3r2 Diaph1 Snap23 Daam1 Stom Racgap1 Vamp3 Arhgap35 Depdc1b Cav1 Ktn1 Arhgap5 Bcap31 Arhgap1 Tjp2 Stx5 Ykt6 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Tlr10 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%10231240 VLDL clearance Apoc4 Vldlr Apobr Apoc1 Apob APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 97%10229186 APC C:Cdc20 mediated degradation of Cyclin B Anapc16 Ube2d1 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Rps27a Ube2e1 Cdc16 Ccnb1 Ubb Ubc Uba52 Cdk1 Ube2s Cdc20 Ube2c Cdc27 Cdc26 Cdc23 Anapc10 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 97%10229628 Platelet Adhesion to exposed collagen Fyn Gp6 Fcer1g Lyn MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%10230492 Molecules associated with elastic fibres Fbln2 Itgb3 Fbln5 Efemp2 Tgfb1 Bmp7 Tgfb2 Tgfb3 Ltbp3 Ltbp2 Mfap4 Ltbp4 Mfap5 Ltbp1 Mfap2 Itgb8 Itgb1 Bmp4 Itga8 Bmp10 Vtn Itgb6 Itgav Bmp2 Gdf5 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%10228660 DNA Damage Bypass Pold3 Rev1 Rps27a Rev3l Poli Polh Polk Ube2l6 Pole3 Pole2 Uba52 Ube2b Pole4 Nploc4 Sprtn Ufd1 Trim25 Isg15 Pclaf Wdr48 Rpa1 Rpa2 Ddb1 Usp1 Cul4a Usp43 Pold1 Rpa3 Rchy1 Dtl Pold4 Cul4b Pole Ubb Ubc Rad18 Usp10 Rbx1 Rfc5 Uba7 Pold2 Vcp Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases Casp2 Cradd Pidd1 Atm TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230050 Type I hemidesmosome assembly Plec Dst Cd151 Megf11 Itgb4 Itga6 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-RNO-196836.1 Vitamin C (ascorbate) metabolism Slc23a2 Cyb5a Slc2a1 Gsto1 Slc2a3 Gsto2 Cyb5r3 Slc23a1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 97%10229828 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ffar4 Dpp4 Ffar1 Gcg Grp Lep Gpr119 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening Cacna2d3 Cacna2d2 Cacng4 Cacnb3 Cacng2 Cacnb4 Cacna1e Cacna1a Cacna1b Cacnb1 Cacnb2 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5685938.1 HDR through Single Strand Annealing (SSA) Rad50 Rad52 Rad9a Ercc1 Rad9b Bard1 Ercc4 Top3a Abl1 Topbp1 Rbbp8 Brca1 Rad17 Rad1 Atm Atr Rpa1 Rpa2 Lig1 Rpa3 Rmi2 Rmi1 Brip1 Mre11 Kat5 Exo1 Nbn Hus1 Rfc5 Atrip Rhno1 Rfc3 Dna2 Wrn Rfc4 Blm Rad51 Rfc2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Dpp4 Ffar1 Gip Gpr119 VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction Rdh11 Rdh10 Fnta Fntb Lpl Apoc2 Akr1c3l1 Apoc3 Apoa2 Sdc1 Sdc2 Apoe Apoa4 Apob Akr1c1 Akr1c9 Cyp4v2 Akr1c12l1 Gpihbp1 Awat2 Pde6g Akr1b10 Lrp1 Sdc4 Sdc3 Lrp8 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Bco2 Gpc4 Nmt1 Bco1 Gpc6 Agrn Calm3 Pde6a Pde6b Clps Pnlip Rbp4 Opn1mw Lrp2 Apom Rbp2 Rbp1 Opn1sw Lrat Dhrs3 Gngt1 Rdh12 Akr1c18 Stra6 Akr1c19 Rpe65 Rbp3 Myo7a Rgs9bp Akr1c21 Rlbp1 Ppef1 Gnb1 Metap1 Rho Metap2 Apoa1 Cnga1 Gnb5 Grk1 Grk4 Rgs9 Camkmt Cngb1 Gnat1 Gucy2e Gpc5 Rcvrn Nmt2 Sag Guca1b Guca1a Akr1c12 Gucy2f Akr1c13 SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS Ptdss1 Ptdss2 SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways Cenpl Cenpk Cenpi Cenph Cenpf Ndc80 Ube2d2 Hif1a Vhl Kl Atp6v0b Flt3 Trib3 Ide Atp6v0a4 Grb10 Pik3c3 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Ptprf Them4 Pde3b Pik3r4 Atp6ap1 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Fgfr3 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Ppm1a Tgif1 Tgif2 Sp1 Tfdp2 Tfdp1 Ccnk Atp1b4 Ccnc Trim33 Rnf111 Smad2 Smad3 Wwtr1 Usp9x Ccnt2 Rbl1 E2f4 E2f5 Skil Notch3 Braf Mknk1 Cd19 Mtmr4 Stom Sgk1 Tax1bp1 Wwp1 Rgs7 Nrp1 Flt1 Nrp2 Prr5 Ncf1 Ncf2 Pdgfc Flt4 Pdgfd Ncf4 Cilp Rictor Tnk2 Alk Brk1 Itgav Mdk Shb Mst1r Kdr Thbs2 Baiap2 Thbs4 Nck1 Grap Sh2d2a Ptk7 Ptpru Nckap1l Pgf Mst1 Itgb3 Ptn Alkal2 Shc2 Alkal1 Bcar1 Fer Nckap1 Elmo2 Ltk Elmo1 Ptpn18 Hspb1 Vegfa Vegfd Vegfc Vegfb Mapk12 Wasf3 Mapk13 Wasf2 Wasf1 Jup Mapkap1 Axl Abi2 Cyba Ctnnd1 Abi1 Cybb Cyfip2 Cyfip1 Map2k1 Ralgds Rap1a Galnt3 Dnajb1 Flot2 Flot1 Epo Epor Slitrk5 Slitrk3 Ntrk3 Fermt2 Actn1 Flna Ywhaq Ywhah Ywhab Stap2 Sfn Zranb1 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 Rgs3 Cdc14a Rgs1 Rgs8 Pcp2 Smpd2 Gpsm3 Smpd3 Gpsm2 Gpsm1 Gna12 Rgs21 Rgs18 Rgs19 Rgs13 Rgs14 Rgs12 Ccr1l1 Kmt2b Casp9 Xiap Il17rd Wdr83 Ksr1 Cnksr2 Araf Pebp1 Nsmaf Cdc25c Fgfrl1 Spred1 Spred2 Rhoc Rhob Pcsk5 Pcsk6 Brap Phb1 Shoc2 Mras Gast Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rapgef4 Rapgef3 Rasgrp1 Rasgrp2 Tln1 Otulin Hmox2 Elf3 Clip3 Sppl2b Sppl2a Pea15 Ptpn7 Paqr3 Erbb2 Ralgdsl1 Dusp16 Cdc37 Dusp10 Flrt1 Rasgrp4 Flrt3 ENSRNOG00000069024 Flrt2 Rasgrf1 Diaph1 Erbb3 Cab39 Cdc14b Nrg2 Cbfb Dusp5 Nrg1 Runx1 Stradb Nrg3 Memo1 Dusp1 App Strada Dusp9 Dusp8 Atf2 Ikbkb Cab39l Atf1 Rapgef2 Rasgef1a Mapk7 Septin7 Mapk8 Mapk6 Traf6 Mapk4 Mapk1 Etv4 Ikbkg Rps27a Map3k7 Mapk3 Nfkb1 Traf2 Skp1 Ppp2cb Ppp2ca Uba52 Ring1 Fos Phc2 Vrk3 Cbx6 Ccnd3 Rela Phc1 Cbx4 Rps6ka3 Cbx2 Phc3 Rps6ka5 Rps6ka1 Bmi1 Rps6ka2 Btrc Yap1 Rnf2 Ppp2r5d Pml Dusp3 Dusp4 Ubb Ripk2 Ubc Dusp7 Dusp6 Casp8 Mapkapk3 Mapk14 Jun Mapkapk2 Irak1 Nfkbia Ppp2r1b Ppp2r1a Cul1 Tab3 Tab2 Tab1 Ikbke Chuk Mapk11 Ncbp2 Ncbp1 Rhog Arhgdib Garre1 Shmt2 Arhgdig Lbr Diaph3 Cdc42ep1 Pgrmc2 Dock5 Dock3 Dock4 Dsg2 Arhgap21 Letm1 Mcam Ophn1 Stbd1 Cdk2 Pld1 Dock2 Vapb Arhgap32 Pak4 Esyt1 Plekhg3 Mpp7 Plcb4 Plcb3 Ankle2 Map3k11 Pla2g4a Pdyn Hspe1 Plcb2 Spata13 Plcb1 Srgap1 Ppp1r1b Srgap2 Srgap3 Gng10-ps1 Arhgap45 Adcy3 Gmip Adcy4 AABR07032856.1 Adcy1 Arhgap10 Adcy2 Camkk1 Arhgap17 Bcr Adcy7 Camkk2 Dock6 Arhgap4 Adcy8 Fam13b Ppp1ca Dock7 Adcy5 Dock8 Adcy6 Arap1 Adcy9 Arap3 Pde4a Arap2 Pde4b Arhgap22 Prkaca Prkacb Arhgap9 Arhgap20 Prkcg Syde1 Prkcd Oprm1 Arhgap26 Arhgap24 Gnai2 Arhgap29 Gnai1 Arhgap27 Prkca Def6 Gnai3 Gna11 Myo9b Camk4 Arhgap33 Prkar1a Arhgap31 Gna14 Arhgap30 Dnmbp Prkar1b Prex2 Calm3 Tagap Gng3 Dock10 Grk2 Dock11 Gnal Plekhg1 Pomc Farp1 Gng5 Ralbp1 Gng4 Stard8 Pde4c Dlc1 Gnaq Stard13 Gng7 Arhgap40 Pde4d Arhgap44 Gng8 Gngt1 Arhgap42 Cdc42bpa Gnat3 Cdc42ep4 Prkar2a Syde2 Cdk5 Pde1b Pld2 Abl2 Pde1c Slc1a5 Gnb2 Pde1a Jag1 Nox3 Gnb1 Nox1 Gnb4 Gnb3 Swap70 Amigo2 Gnb5 Noxa1 Gng11 Arhgap15 Gng12 Arhgap12 Cit Fam13a Baiap2l1 Arhgap25 Arhgap23 Fgd5 Pak6 Pak5 Fmnl1 Git2 Aldh3a2 Noxo1 Taok3 Chn2 Plekhg6 Farp2 Sh3bp1 Pkn2 Pkn1 Abcd3 Acbd5 Ube2l3 Birc2 Dsp Stub1 Bcap31 Tjp2 Parp1 H2ab2 Prkaa1 Derl2 H2ac4 Rbx1 Spop Vcp Prkag3 Psmb6l1 Prkag1 Prkag2 Nedd4 Ccnd1 Cdk4 H2ac18 Cul3 Ezh2 Psma4 Psma3 Psma6 Erlec1 Sh3rf1 Psma5 Psma2 Psma1 Csnk2a2 Csnk2a1 Ywhag Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Wdr5 Ash2l Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Mkrn1 Eed Psmb3 Psmb2 Gsk3b H2aj Kbtbd7 Os9 Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Sel1l H2bc18 Rbck1 Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Mib2 Psmd1 Adrm1 Prkab2 Hist1h2ai Prkab1 Lpar5 Plppr1 Plppr4 Ube2m Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 S1pr4 Lpar3 Lpar1 Rnf41 Spta1 Lrrc41 Ptpra Col4a1 Col4a2 Ncam1 Sptbn1 Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Sptbn4 Nras Grb2 Fyn Kras Sos1 Hras Arl13b Pde6d Cul5 Ndufs3 Ndufa5 Rbbp6 Polr2c Polr2a Polr2b Polr2g Polr2h Rhot2 Polr2e Mfn1 Polr2f Mfn2 Trak1 Polr2i Myo19 Trak2 Polr2j Gtf2f2 Gtf2f1 Tbp Gtf2a1 Gtf2a2 Pgk1 Ntf3 Ntf4 Ntrk2 Bdnf Sphk1 Lyn Yes1 Src Itga3 Rhoa Ngef Zap70 Lck Pik3r5 Pik3r6 Pik3cg Icos Lrrk2 Gpnmb Raf1 Jak2 Ddx39b Ptbp1 Pde10a Pde11a Hnrnpc Nos3 Hnrnpf Prkg2 Pde5a Pde2a Itpr1 Crkl Tbk1 Srrm1 Ppp1cb Stat5a Stat5b Hnrnph1 Stat6 Il1rap Csf2rb Jak3 Tyk2 Syk Gab2 Vav1 Pik3r1 Pik3r2 Pik3r3 Il33 Il6st Cpsf7 Rapgef1 Stat3 Stat1 Socs3 Irs1 Irs2 Ybx1 Sqstm1 Csf2 Shc1 Il2 Il3 Il6 Il5 Irak4 Pik3cb Il6r Pik3cd Pik3ca Myd88 Ptprz1 Il2ra Il2rb Hnrnpa1 Il1rl1 Smarca4 Sos2 Crk Tra2b Ywhaz Ptpn6 Cbl Ptpn11 Casp3 Ptk2b Tec P4hb Smo Csnk1a1 Lmnb1 Picalm Ocrl Clta Cltc Wipf3 Wipf1 Btk Sh3gl2 Nckipsd Limk1 Arrb1 Tfrc Cpd Trpc7 Trpc3 Itpr3 Itpr2 Fadd Ripk1 F2r Arrb2 F2 F2rl2 F2rl3 Ranbp9 Ranbp10 Kdm4c Ppp1r12b Ppp1r14a Ar Ppp1r12a Itga8 Cftr Itga2 Itgb6 Dkk4 Kremen2 Kremen1 Sost Lman1 Dkk1 Dkk2 Gja1 Sox3 Sox9 Sox7 Sox6 Akt3 Pygo2 Sox4 Akt2 Pygo1 Tle4 Tle2 Akt1 Tnks2 Hecw1 Klhl12 Axin2 Optn Rnf43 Tcf7 Sox13 Tcf7l1 Sox17 Itsn1 Bcl9l Bcl9 LOC134484451 Rnf146 Cby1 Znrf3 Itsn2 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Myo6 Dact1 Sry Leo1 Ryk Ctnnbip1 Fzd4 Lgr5 Lgr6 Pip5k1b Rasal1 Rasal2 Rasal3 Syngap1 Spred3 Rasa2 Rasa4 Snap23 Rasa3 Nf1 Dab2ip Sharpin Tnf Usp21 Otud1 Traf1 Spata2 Rnf31 Usp2 Usp4 Hbegf Rack1 Cltb Cyld Otud7b Agtr1 Vamp3 Areg Grb7 Arf6 Gps1 Stx5 Ykt6 Ap2s1 Eps15l1 Trip10 Pip5k1c Cenpe Madd Arfgap3 Eps15 Egfr Klc1 Dync1li2 Dync1li1 Rab4a Klc4 Klc3 Chrm2 Klc2 Dvl2 Cops4 Arpc3 Cops2 Arpc2 Arpc5 Arpc4 Ap2m1 Sh3gl3 Mob1a Sh3kbp1 Lats1 Mob1b Lats2 Wwc1 Amotl2 Amotl1 Stk4 Amot Stk3 Sav1 Nphp4 Sh3gl1 Cep97 Osbpl11 Rhobtb3 Pard6b Uaca Arhgap6 Mrtfa Arhgap8 Stmn2 Fam91a1 Mylk Mtmr1 Samm50 Fam169a Baiap2l2 Vma22 Gopc Ralgapa1 Wwp2 Fam135a Wdr11 Tuba1b Msi2 Stip1 Slk Phip Tpm4 Akap12 Ins1 Stk38 Scfd1 Tex2 Ins2 S100a9 S100a8 Stk10 Arhgap19 Arhgap18 Evl Pafah1b1 Rhobtb2 Ereg Rhobtb1 Zw10 Srf Arhgap28 Pcdh7 Prc1 Rnf20 Cct6a Cdc42bpb Slc4a7 Sowahc Senp1 Pfn2 Twf1 Epsti1 Cpne8 AABR07021573.2 Nipsnap2 Faf2 Rhoh Rhof Anln Actr2 Rhoj Avpr2 Btc Rhou Actr3 Rhov Rhoq Arpc1a C1qbp Ulk1 Scai Arhgap11a Emc3 Cct7 Myo9a Ccdc88a Stam Tmem59 Mtx1 Cavin1 Tmod3 Cdc42ep2 Cdc42ep3 Plxna1 Rras2 Rtkn Nsfl1c Rhpn1 Rhpn2 Ccdc187 Basp1 Ddrgk1 Kif18a Maco1 Ddx4 Peak1 Rnd3 Rnd1 Spen Armcx3 Add3 Ccp110 Rab7a Tor1aip1 Sema4f Dync1h1 Fmnl2 Actc1 Fmnl3 Tmem87a Zfp512b Tgfa Dync1i2 Dync1i1 Avp Rab9a Rab9b Sec13 Ap2b1 Racgap1 Pik3ap1 Tmed2 Tjp1 Nedd8 Cd55 Wnt5a Adrb2 Kif5a Pten Kif5b Tsc2 Tsc1 Ap2a2 Ap2a1 Hgs Tacr1 Kif2a Kif2b Kif2c Grk3 Cd28 Dynll1 Dynll2 Kif3a Cd86 Cd80 Ywhae Stam2 Trat1 Epn1 Foxo6 Foxo4 Als2 Foxo1 Fnbp1 Egf Sfpq Khdrbs1 Khdrbs3 Khdrbs2 Ptk6 Rps6 Rps27 Megf11 Lama4 Tns4 Tns3 Ffar4 Ghrl Csnk1e Igf1 Inhbb Pard3 F11r Ret Shc3 Nup98 Nup37 Nup107 Nup160 Nup85 Nup43 Mark3 Artn Aaas Ranbp2 Gfra1 Gfra2 Nup133 Gfra4 Lamtor5 Rptor Kit Akt1s1 Lamtor3 Rraga Lamtor4 RragB Lamtor1 Eef2k Rragc Lamtor2 Fkbp1a Rragd Eif4ebp1 Kitlg Mtor Eif4e Rheb Rps6kb1 Mlst8 Map2k2 Slc38a9 Plxnb1 Dok1 Adora2b Pspn Adora2a Gdnf Ednrb Ednra Sct Fes Npff Rrh Ptgdr Htr4 Nrtn Apln Trhr Tas2r39 Htr6 Oprd1 Htr7 Tas2r38 C3ar1 Crhbp Galr2 Galr3 Galr1 Cmklr1 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Lhb Ppbp Fpr1 Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Vipr2 Nln Vipr1 C5 Rgs20 Ptgfr Rgs17 Pnoc Rgs16 Tas2r16 Gnaz Fst Tas2r13 Tgfb1 Ppy Tgfb2 Tas2r135 Tgfb3 Cga Cgn Tas2r136 Nmb Bambi Ltbp3 Oxtr Ltbp2 Lpar6 Xcr1 Ltbp4 Gpr18 Ltbp1 Grpr Itgb8 Gpr17 Acvr1c Nms Strap Acvr1b Tas2r140 Nmu Zfyve9 Tgfbr1 Tas2r145 Tgfbr2 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Brs3 Ptger4 Tas2r7 Gabbr1 Ptger2 Ptger3 Fshr Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Igf2 Crhr1 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr2 Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Taar5 Rgr Taar1 Hcrt Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npffr1 Npy Npffr2 Ghrh Ptgdr2 Rho Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Qrfprl Gpr4 Gcg Ptgdrl Qrfp Ccl27 Agt Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Mc3r P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Tas2r40 Fpr2l1 Tas2r41 Hcar1 Adra2a Prokr2 Adra2c Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Calcr Cxcl12 Casr Cxcl10 C5ar2 C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Calcb Chrm1 Calca Hrh1 Chrm3 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Opn5 Sucnr1 Pyy Adora1 Adora3 Rln3 Wwox Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Rps6kb2 Ece1 Nr4a1 Ece2 Trh Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Qrfpr Insl3 Gip Ptgir Psap Trim27 Htr1d Otud3 Htr1f Glp1r Usp13 Frk Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Mapkapk5 Adgre1 Hgfac Pth2 Tshr Hpn Rab4b Glp2r Gga3 Ccl9 P2ry6 Spint2 Cxcl9 Spint1 Ccl7 P2ry4 Ccl6 P2ry2 Ccl5 P2ry1 Ccl4 Ccl3 Hcrtr2 Hcrtr1 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Ackr4 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb Emd Plk1 Vrk2 Prkcb Cdk1 Itch Dtx2 Dtx4 Vangl2 Golga3 Nudc Rnd2 Muc13 Wdr6 Txnl1 Kif14 Scrib Rbmx Ptpn13 Nisch Arhgap35 Dst Depdc1b Cav1 Fam83b Frs2 Ubxn11 Frs3 Kctd13 Epha2 Kidins220 Ktn1 Arhgap5 Plxnd1 Prag1 Arhgap1 Dlg5 Ankrd26 Dsg1 Bltp3b Tnfaip1 Ckap4 Ctsd Rac1 Vav3 Plcg1 Vav2 Pak1 Pak2 Grap2 Lat Aldh1a1 Usp7 Itgb1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Rgs9 Tlr9 Gnat1 Csk Tgfbr3 Gipc1 Fgfr1 Tiam1 Nck2 Git1 Mmp2 Mmp9 Nab2 Dnal4 Actb Chd4 Arpc1b Egr2 Psenen Arhgef28 Psen1 Psen2 Kalrn Ncstn Aph1a Arhgef7 Aph1b Rasa1 Grin1 Pak3 Actg1 Rbfox2 Esrp2 Cdc42 Esrp1 Tial1 Tia1 Rock2 Rock1 Grin2b Kat5 Chek1 Abl1 Ppp5c Kdm4b Mta1 Mta2 Mta3 Mbd3 Steap3 Gab1 Fgf10 Fgf3 Fgf22 Chd3 Fgf7 Lrp6 Gatad2a Gatad2b Ctnnb1 Ppp2r5b Ppp2r5a Dvl1 Dvl3 Wnt1 Amer1 Fzd1 Fzd2 Fzd5 Ppp2r5e Apc Axin1 Wnt8b Wnt8a Frat2 Frat1 Grem2 Bmp10 Acvrl1 Amhr2 Inha Amh Zfyve16 Cer1 Gdf2 Bmpr1a Bmpr1b Bmpr2 Smad1 Ski Bmp2 Smad4 Ube2d3 Smad9 Acvr2a Ube2d1 Inhba Smurf2 Smurf1 Acvr2b Fstl1 Smad5 Smad6 Jag2 Smad7 Dll1 Dll4 Chrdl1 Hgf Lrig1 Ptpn2 Usp8 Ptpn1 Met Gpr161 Ihh Rpgrip1l Ulk3 Tulp3 Cdon Adcy10 Mecom Dhh Ift140 Ptch1 Disp2 Scube2 Hhip Fuz Srms Hhat Mks1 Ift52 Cdc73 Dzip1 Ttc21b Gli1 Ift57 Gli3 Gli2 Shh Numb Ift122 Ofd1 Intu Kif7 Evc Wdr35 Prkch Spopl Dync2h1 Gpc5 Evc2 Ift172 Wdr19 Notum Pdgfa Sufu Pdgfb Syvn1 Vim Mgll Hdac2 Ctbp1 Ctbp2 Hdac1 Tle1 Kdm1a Dgka Ntrk1 Ngf Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Daglb Tnfrsf1a Dagla Wnt11 Sh2b2 Vps26a Vps35 Tmed5 Wnt6 Wnt2b Vps29 Snx3 Wnt5b Wnt9a Wnt7a Wnt9b Thbs1 Wnt10a Wnt2 Wnt4 Wnt16 Wls Wnt10b Dhrs4 Vcl Pdhx Dhrs3 Aldh1a2 Aldh1a3 Nrip1 Abhd12 Akr1c18 Akr1c19 Hsp90aa1 Plat Cyp26b1 Akr1c21 Pdk4 Pdk3 Angpt1 Dhrs9 Ppid Pdk2 Uhmk1 Pdk1 Sdr16c5 Ppidl1 Tle3 Nr1h3 Nr1h2 Pdhb Hsp90ab1 Tek Rxrb Rxra Akr1c12 Cyp26a1 Akr1c13 Zdhhc7 Pgr Gata3 Rxrg Rdh11 Rdh10 Tbl1x Rdh13 Rdh14 Adh4 Pip4k2b Pdha1 Pip4k2c Adh1 Pip4k2a Pdha2 Greb1 Cited1 Strn Prkcz Cav2 Esr1 Esr2 Abca1 Cdk9 Crebbp Akr1c3l1 Crabp1 Crabp2 Igf1r Rdh7 Hdac3 Pou2f1 Xpo1 Pdpk1 Prmt1 Tbl1xr1 Rara Foxo3 Mmp7 Mmp3 Zdhhc21 Ppard Fkbp4 Fkbp5 Ptges3 Akr1c1 Akr1c9 Pip5k1a Dld Ncor2 Carm1 Aldh8a1 Ep300 Gps2 Akr1c12l1 Zfp217 Foxa1 Ncoa3 Kat2b Rarg Fabp5 Yy1 Cyp26c1 Dlat Cdkn1b Nr5a2 Prkce Mcf2l Tiam2 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Clip1 Cdh1 Ctnna1 Iqgap2 Iqgap3 Men1 Ncoa2 Adam10 Mmp14 Mmp16 Plg Spp1 Furin Cma1 Timp1 Timp2 Tradd Fas Cflar Faslg Tnfsf10 Ckb Mtr Dbt Stk11 Pde6g Pard6a Daam1 Ror1 Ror2 Pfn1 Gnao1 Nlk Tcf7l2 Ppp3ca Fzd3 Ppp3cb Fzd7 Fzd6 Fzd8 Rac2 Rac3 Nfatc1 Lef1 Ppp3r1 Camk2a Gnat2 Pde6a Pde6b Prickle1 Ccne1 Cct2 Icmt Zdhhc9 Bcl2l1 Abhd17b Arl2 Abhd17a Prkcq Golga7 Fnta Lypla1 Fntb Abhd17c Rce1 ENSRNOG00000067432 Fgfbp3 Fgfbp1 Arhgdia Adam17 Omg Mag Prkci Ngfr Bex3 Rtn4 Itgb3bp Casp2 Pxn Ptpn3 Ptpn12 Pag1 Fam83a Spry2 Spry1 Fam83d Aamp Ier3 Phlpp1 Maf1 Sall4 Pdgfrb Pdgfra Grin2d Lrrc7 Actn2 Nefl Lin7b Dlg1 Dlg2 Dlg3 Dlg4 Camk2g Camk2d Camk2b Pde3a Clasp1 Pde7a Clasp2 Grk5 Spc24 Grk6 Birc5 Pde8a Spc25 Pde8b Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Zwilch SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 97%10230696 Sensory perception of salty taste Scnn1b Scnn1g Scnn1a FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-RNO-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex Bcl7c Actg1 Actl6a Bcl11a Bcl11b Phf10 Smarce1 Smarcc1 Ss18 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Smarca4 Dpf2 Arid1a Bcl7a Bcl7b ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%10228432 Activation of the phototransduction cascade Gngt1 Cngb1 Gnat1 Pde6a Pde6b Gnb1 Rho Cnga1 Pde6g FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing Rbfox2 Esrp2 Esrp1 Tial1 Tia1 Polr2c Ptbp1 Polr2a Polr2b Polr2g Polr2h Hnrnpa1 Polr2e Polr2f Polr2i Hnrnpf Ncbp2 Polr2j Ncbp1 Hnrnph1 Gtf2f2 Gtf2f1 PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 97%10231654 PKR-mediated signaling Tarbp2 Npm1 Ppp2r1b Ppp2r1a Adar Chuk Ube2l6 Eif2ak2 Arih1 Trim25 Isg15 Ppp2r5a Tp53 Sphk1 Cdk1 Ikbkb Hspa8 Ilf2 Ilf3 Snca Mavs Ikbkg Faap100 Hspa2 Dnajc3 Stat3 Fancl Stat1 Fancm Ptpn2 Fanca Fancb Fancc Fance Fancf Fancg Ppp2cb Dus2 Ppp2ca Hspa1b Hspa1a Hspa1l Dhx9 Faap24 Faap20 Map2k6 Nck1 Mapt Prkra LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-RNO-8853383.1 Lysosomal oligosaccharide catabolism Manba Man2c1 Man2b1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231342 RUNX3 regulates YAP1-mediated transcription Runx3 Yap1 Tead3 Tead2 Tead4 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229824 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Gnas Prkaca Prkacb Itpr3 Itpr2 Gng3 Rapgef4 Gng5 Rapgef3 Gng4 Gng7 Gng8 Gngt1 Rap1a Gnb2 Gnb1 Kcnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Kcns3 Gcg Gng10-ps1 Kcnc2 Glp1r Itpr1 Kcng2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-RNO-156711.1 Polo-like kinase mediated events Pkmyt1 Cdc25c Wee1 Foxm1 Plk1 KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 97%10230970 KEAP1-NFE2L2 pathway Cul1 Cul3 Akt3 Bach1 Psma4 Psma3 Akt2 Psma6 Psma5 Akt1 Psma2 Crebbp Psma1 Psmd12 Psmd11 Mul1 Psmd14 Psmd13 Ubxn7 Psmb5 Psmb4 Keap1 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Ep300 Prkci Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Prdx1 Srxn1 Trim21 Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Sqstm1 Skp1 Map1lc3b Uba52 Nploc4 Ufd1 Nfe2l2 Btrc Sesn2 Sesn1 Ubb Ubc Rbx1 Vcp Psmb6l1 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231408 RHOU GTPase cycle Nck2 Pard6a Git1 Usp9x Rhou Arhgef6 Wdr6 Txnl1 Stam Arhgap31 Arhgap30 Stam2 Dst Arhgef7 Depdc1b Cltc Epha2 Wwp2 Pak3 Cdc42 Itsn2 Peak1 Dlg5 Myo6 Sptbn1 Pak4 Sptan1 Pik3r1 Pik3r2 Grb2 Pak1 Hgs Srgap2 Git2 Nck1 Pak2 Ptk2b REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%10230834 Regulation of FZD by ubiquitination Znrf3 Rspo1 Rspo3 Rspo2 Rspo4 Fzd5 Rps27a Fzd6 Fzd8 Fzd4 Lgr5 Lgr6 Ubb Ubc Uba52 Rnf43 Lrp6 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%10228556 mRNA Capping Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Rnmt Ncbp2 Ncbp1 Polr2c Polr2a Polr2b Ramac Polr2g Polr2h Polr2e Polr2f Rngtt Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 97%10230596 IRF3-mediated induction of type I IFN Tbk1 Nlrp4 Sting1 Irf3 Dtx4 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10228632 L1CAM interactions Itgb3 Sdcbp Ank1 Ezr Egfr Csnk2a2 Csnk2a1 Clta Itga2b Cltc Lypla2 Dnm1 Rac1 Map2k1 Dnm3 Csnk2b Dnm2 Vav2 Sh3gl2 L1cam Src Dpysl2 Pak1 Map2k2 Ap2m1 Mapk1 Mapk3 Ap2b1 Msn Rdx Itgb1 Ranbp9 Kif4b Gap43 Kif4a Spta1 Ncam1 Numb Sptbn1 Sptb Sptbn2 Sptan1 Nrp1 Sptbn5 Itga9 Sptbn4 Ap2a2 Ap2a1 Ap2s1 Fgfr1 Itgav Nfasc GABA SYNTHESIS%REACTOME%R-RNO-888568.1 GABA synthesis Gad1 Gad2 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism Fabp2 Gpd2 Fabp3 Pnpla4 Fabp4 Fabp7 Fabp5 Fabp9 Fabp6 FABP12 Fabp1 Pnpla5 SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies Hmgcs2 Acss3 Hmgcl Acat1 Aacs Bdh2 Bdh1 Hmgcll1 REGULATION OF PYRUVATE METABOLISM%REACTOME%R-RNO-9861718.1 Regulation of pyruvate metabolism Pdha1 Rps27a Pdha2 Uba52 Pkml1 Wdr26 Nek1 Mkln1 Pdhx Ranbp9 Gid4 Gstz1 Maea Ldha Me1 Armc8 Pdk4 Dld Rmnd5b Pdk3 Pdk2 Pdk1 Ubb Ubc Pdhb Pgam5 Dlat Pdp1 Pdpr Pdp2 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 97%10229830 Incretin synthesis, secretion, and inactivation Ffar4 Dpp4 Ffar1 Gcg Gip Grp Lep Gpr119 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%10229276 Oncogene Induced Senescence Cdk6 Ets1 Ets2 Mapk1 Tp53 Cdk4 Rps27a Mapk3 Erf Ubb Mdm4 Ubc Uba52 Id1 Cdkn2b Cdkn2d FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 97%10229080 Fc epsilon receptor (FCERI) signaling Nfkbia Tec Prkcq Cul1 Tab3 Ube2d2 Tab2 Tab1 Psma4 Psma3 Psma6 ENSRNOG00000069193 Chuk AABR07065813.1 Psma5 Mapk10 ENSRNOG00000062915 Psma2 Igll1 Psma1 Cdc34 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 Nfatc3 Psmd12 ENSRNOG00000070810 Nfatc2 ENSRNOG00000066926 Psmd11 ENSRNOG00000066406 Pdpk1 Rac1 Psmd14 ENSRNOG00000067897 ENSRNOG00000062685 Psmd13 Vav3 ENSRNOG00000070192 Plcg1 Psmb5 Iglc1 Plcg2 Psmb4 ENSRNOG00000070159 ENSRNOG00000071049 Psmb7 Btk Psmb6 AABR07034736.1 Psmb1 Vav2 ENSRNOG00000065564 Psmb3 ENSRNOG00000066971 Psmb2 ENSRNOG00000063341 ENSRNOG00000070986 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Psma7 Lcp2 Igkvl13 Psmc5 AABR07065812.2 Psmc2 ENSRNOG00000063707 ENSRNOG00000067679 Psmc1 Psmc4 Pak1 ENSRNOG00000070832 Psmc3 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 Psmd7 Pak2 Psmd6 Grap2 Psmd8 ENSRNOG00000064490 Ube2d1 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Lat ENSRNOG00000067643 Psmd1 Adrm1 Calm3 Nras Grb2 Kras Sos1 Hras Syk Gab2 Vav1 Pik3r1 Pik3r2 Mapk9 Ikbkb Mapk8 Txk Traf6 Mapk1 Fcer1a Ikbkg Lat2 Ms4a2 Ppp3ca Rps27a Map3k7 Mapk3 Ppp3cb Ube2n Bcl10 Nfkb1 Nfatc1 Ppp3r1 Skp1 Itk Uba52 Fbxw11 Fos Rela Fcer1g Shc1 Map3k1 Malt1 Btrc Pik3cb Pik3ca Map2k7 Ubb Ubc Jun Psmb6l1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 97%10229802 Mitotic Prophase Arpp19 Ncapd3 Nup58 Nup37 Nup205 Pom121 Ncapg2 Gorasp1 Rb1 Nup107 Nup188 H2ac18 Lmna Tpr Lmnb1 Gorasp2 Nup160 Kmt5a Rae1 Mastl Ndc1 Rab1b Mcph1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Hist1h2bq Nup214 Smc4 Ranbp2 Smc2 Nup155 Nup133 Nup210 Nup153 Cnep1r1 Ctdnep1 Emd Ccnb2 H2aj Nek9 Ccnb1 Plk1 Lpin3 Lpin2 Vrk1 Hist3h2ba Vrk2 Prkcb Banf1 Cdk1 Ccnb2-ps2 Phf8 H2az2 H2bc6 Mapk1 H2bc4 Hist1h4m H2bc1 Mapk3 Sec13 Prkca Hist1h2ai Set Rab1A Rab2a Numa1 Golga2 H2ab2 H2ac4 Blzf1 Nup93 Ncaph2 Nup50 Nup35 Nup54 Nup98 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229226 Chylomicron assembly Mttp Apoc2 Sar1b P4hb Apoc3 Apoa2 Apoe Apoa4 Apoa1 Apob APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-RNO-351906.1 Apoptotic cleavage of cell adhesion proteins Tjp2 Dsg2 Dsp Dsg1 Cdh1 Pkp1 Dsg3 Tjp1 Ocln Casp3 Ctnnb1 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 97%10230062 Zinc efflux and compartmentalization by the SLC30 family Slc30a8 Slc30a1 Slc30a5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 97%10229552 Role of LAT2 NTAL LAB on calcium mobilization ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Pdpk1 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Syk ENSRNOG00000065564 Gab2 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000070986 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 Pik3r1 ENSRNOG00000063148 Pik3r2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 Lat2 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Shc1 Pik3cb Pik3ca Grb2 Sos1 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230838 SUMOylation of DNA methylation proteins Ube2i Sumo1 Dnmt1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%R-RNO-140342.1 Apoptosis induced DNA fragmentation Dffa Dffb Hmgb1l2 Hmgb1l1 Kpnb1 Kpna1 Hmgb2 Hmgb1-ps34 H1-1 H1-0 H1-5 H1-4 Casp3 H4f3 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-RNO-211945.1 Phase I - Functionalization of compounds Cyp24a1 Ces2h Adh4 Adh1 Aldh1b1 Bphl Ptgs1 Cyb5b Cyp2c66 Cyp2c11 Ptges3 Cyp2e1 Cyp1a1 Cyp1a2 Cyp26c1 Cyp3a9 Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Aoc1 Aldh1a1 Fmo1 Cyp2s1 Pomc Cyb5r3 Cyp2j16 Cyp4f39 Adh7 Maoa Cyp2j3 Cyp4f1 Cyp2f2 Cyp4a14 Cyp2b1 Cyp4f3 Cyp4f40 Cyp4a12 Cyp4b1 Cyp2a2 Cyp4f4 Cyp4a10 Cyp2a1 Cyp2d4 Cyp4a2 Cyp2a3 Arnt Ahr Cyp39a1 Cyp19a1 Ncoa2 Cyp11a1 Cyp1b1 Smox Ahrr Cyp2u1 Cyp51a1 Cyp8b1 Cyp7b1 Nr1h4 Cyp4v2 Cyp21 Cyp46a1 Cyp2w1 Cyp27a1 Arnt2 Cyp11b1 Fdx1 Ces1d Cyp11b3 Cyp11b2 Fdxr Fdx2 Adh6 Cyp7a1 Aldh2 Adh5 Cyp27b1 Cmbl Ephx1 Aldh3a1 Aadac Acss2 Tbxas1 Maob Ptgis Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Cyp2c24 Cyp26b1 Hsp90ab1 Rxra Cyp26a1 Acss1 Mtarc2 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 97%10229648 Miscellaneous substrates Cyp2u1 Cyp4f39 Cyp4f1 Cyp3a9 Cyp4a14 Cyp2w1 Cyp4f3 Cyp4f40 Cyp4a12 Cyp4b1 Cyp3a18 Cyp4f4 Cyp3a1 Cyp4a10 Cyp3a62 Cyp2d4 Cyp3a2 Cyp4a2 Cyp2s1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-RNO-1268020.1 Mitochondrial protein import Hspd1 Atp5f1b Ndufb8 Fxn Hscb Ldhd Coq2 Atp5mc3 Pitrm1 Otc NURD COMPLEX ASSEMBLY%REACTOME%R-RNO-9937850.1 NuRD complex assembly H2bc6 Rbbp4 Zfp592 H2bc4 Hist1h4m H2bc1 Cdk2ap1 Rbbp7 Chd4 Hdac2 Nr2f2 Zmynd8 H2ac18 Ikzf3 Hdac1 Ikzf1 Chd5 Hist1h2ai Mta1 Mta2 Zfp827 Tcf19 Mta3 Zfp532 Mbd3 Pwwp2a Mbd3l1 Mbd2 Mbd3l2 Nr2c2 Chd3 Hist1h2bq Gatad2a Gatad2b Phf6 H2aj H2ab2 Ube2i H3-3b Hist3h2ba Sumo1 H2ac4 H2bc18 H2az2 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230526 HS-GAG degradation Naglu Sdc4 Sdc3 Hpse2 Hpse Gpc1 Gpc3 Gpc2 Ctsl Gpc4 Sgsh Gpc5 Gpc6 Agrn Idua Sdc1 Sdc2 Ids MET ACTIVATES RAP1 AND RAC1%REACTOME%R-RNO-8875555.1 MET activates RAP1 and RAC1 Met Dock7 Grb2 Rap1a Rap1b Gab1 Crk Rapgef1 Hgf Rac1 Crkl BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins Alox5 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 97%10231440 LXRs regulate gene expression linked to cholesterol transport and efflux Abca1 Tbl1x Nr1h3 Nr1h2 Rxrb Hdac3 Rxra Ncor2 Tbl1xr1 Ep300 Gps2 PTK6 REGULATES CELL CYCLE%REACTOME%R-RNO-8849470.1 PTK6 Regulates Cell Cycle Ccnd1 Cdk4 Ccne1 Cdk2 Ptk6 Cdkn1b RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231396 RAC2 GTPase cycle Git1 Nckap1 Wasf2 Mtx1 Abi2 Cyba Abi1 Cybb Garre1 Cyfip1 Lbr Diaph3 Vav3 Cdc42ep1 Pgrmc2 Cdc42 Dock3 Dock4 Dsg2 Arhgap21 Armcx3 Vav2 Mcam Ophn1 Rab7a Stbd1 Arhgdia Emd Vav1 Dock2 Vapb Arhgap32 Lamtor1 Pik3r1 Pak4 Pik3r2 Esyt1 Pik3r3 Mpp7 Ankle2 Vrk2 Pak1 Slitrk5 Tfrc Arhgap17 Bcr Pak2 Syde1 Arhgap26 Racgap1 Rac2 Def6 Vamp3 Arhgap35 Depdc1b Abr Cav1 Dock10 Samm50 Epha2 Prex1 Itgb1 Trio Mcf2 Arhgap42 Arhgap1 Cdc42ep4 Pld2 Pik3ca Swap70 Baiap2l1 Ncf1 Ncf2 Ncf4 Brk1 Git2 Taok3 Tiam1 Lman1 Nckap1l MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%10230880 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Pold3 Rpa1 Rpa2 Lig1 Pold1 Rpa3 Pold2 Pold4 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-RNO-196843.1 Vitamin B2 (riboflavin) metabolism Enpp1 Rfk Slc52a2 Slc52a3 Acp5 Flad1 ERK MAPK TARGETS%REACTOME%R-RNO-198753.1 ERK MAPK targets Mapk7 Rps6ka1 Mapk1 Rps6ka2 Ppp2r1b Ppp2r1a Mapk3 Ppp2r5d Dusp3 Dusp4 Mapk11 Ppp2cb Ppp2ca Dusp7 Dusp6 Vrk3 Mapk14 Rps6ka3 Rps6ka5 OPSINS%REACTOME DATABASE ID RELEASE 97%10229972 Opsins Opn5 Rgr Opn1mw Opn4 Rho Rrh Opn3 Opn1sw ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%10231778 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA Ube2d2 Ube2d3 Ube2d1 Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Trip4 Rpl7 Ascc3 Ascc2 Rpl30 Zfp598 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rps27a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubb Ubc Fau Rpl23a IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-RNO-937041.1 IKK complex recruitment mediated by RIP1 Ube2d1 Traf6 Ikbkg Tlr4 Rps27a Ube2n Ube2d2 Ticam2 Cd14 Chuk Ticam1 Ubb Birc2 Sarm1 Ripk3 Ubc Uba52 Ripk1 Ly96 Ikbkb Ube2d3 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-RNO-72649.1 Translation initiation complex formation Rps25 Rps26 Rps27 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Rps15a Rps4x-ps13 Rps3a Rps27l Eif4e Eif1ax Eif4a2 Rps26-ps13 Eif4a1 Pabpc1 Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Rps14 Eif3h Rps15 Eif3g Eif3b Rps16 Eif3a Eif3d Rps17 Eif3c Rps18 Rps19 Rpsa Uba52 Rps10 Rps11 Rps3 Rps2 Rps13 Rps4x Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Fau RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%10228482 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Taf4b Taf7l-ps1 Gtf2a1 Cdk7 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Taf4 Gtf2e1 Taf2 Taf1 Gtf2e2 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Taf9b Polr2j Taf15 Taf11 Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 97%10228896 FXIIa activates plasma kallikrein-kinin system Hrg H2bc6 H2bc4 Hist1h4m H2bc1 H2az1 Krt1 Prcp H2ac18 C1qbp Hist1h2ai H2ab2 Plaur F12 H3-3b Hist3h2ba H2ac4 Klkb1 Serping1 A2m Kng1 H2bc18 Hist1h2bq LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9037629.1 Lewis blood group biosynthesis St3gal6 B3galt4 St3gal4 Fut2 B4galnt2 Fut4 Fut7 Fut9 B3galt5 St3gal3 St6galnac6 B3galt1 MITOTIC G2-G2 M PHASES%REACTOME%R-RNO-453274.1 Mitotic G2-G2 M phases Cdc25c Dynll1 Cdc25a Ccnh Ppp2r1b Ppp2r1a Cdk7 Cul1 Psma4 Ajuba Psma3 Psma6 Psma5 Ywhae Psma2 Psma1 Ywhag Psmd12 Psmd11 Xpo1 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Cdk2 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Pcnt Psmc1 Psmc4 Psmc3 Ppp2r2a Tpx2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Psmd7 Psmd6 Psmd8 Psmd2 Prkaca Psmd1 Adrm1 Csnk1d Cep192 Tubgcp2 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Mzt1 Mzt2 Phlda1 Cep43 Cep41 Ninl Tubb5 Odf2 Ppp1r12b Haus7 Haus8 Haus4 Ppp1r12a Haus5 Haus6 Cpap Ofd1 Haus1 Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Tubgcp3 E2f1 E2f3 Cdk11b Nedd1 Ppp2r3b Lcmt1 Obi1 Foxm1 Pcm1 Ssna1 Tubg2 Actr1a Tubg1 Cdc25b Akap9 Nme7 Aurka Sfi1 Fkbpl Dctn1 Cetn2 Dctn2 Bora Fbxl7 Cep250 Cep135 Ppp1cb Cep131 Cdk5rap2 Cep152 Optn Cep290 Cep164 Ppme1 Ticrr Ccp110 Dync1h1 Ccnb2 Ccnb1 Plk1 Mis18bp1 Hjurp Cdk1 Ccnb2-ps2 Dync1i2 Csnk1e Rps27a Clasp1 Skp1 Ppp2cb Ppp2ca Uba52 Rab8a Fbxw11 Ccna1 Ccna2 Sgo1 Ckap5 Hsp90aa1 Btrc Fzr1 Mapre1 Pkmyt1 Ubb Mnat1 Nde1 Ubc Gtse1 Wee1 Hsp90ab1 Rbx1 Psmb6l1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-RNO-399954.1 Sema3A PAK dependent Axon repulsion Plxna4 Plxna3 Plxna2 Hsp90aa1 Nrp1 Limk1 Fyn Pak1 Hsp90ab1 Sema3a Plxna1 Fes Rac1 Pak2 Pak3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%10228786 Response to elevated platelet cytosolic Ca2+ Itgb3 Vegfa Vegfd Vegfc Vegfb Aldoa Cyb5r1 Egf Cd36 Kng1 Tuba4a Prkcg Hgf Prkca Serpina1 Calm3 F13a1 Actn1 Flna Abcc4 Phactr2 Stxbp3 Apoa1 Alb Vti1b Chid1 Actn2 Cfd Pcdh7 A1bg Serping1 Psap Pdgfa Clu Serpine1 Ppbp Pdgfb Islr Pcyox1l Stxbp2 AABR07021573.2 Hrg Sparc Lhfpl2 Gas6 Sytl4 Ly6g6f Tgfb1 Ahsg Tgfb2 Spp2 Tgfb3 Cd109 Serpina3n Timp3 Fn1 Fam3c Fgb Fga Serpinf2 Fgg Itga2b Tln1 Anxa5 Actg1 Qsox1 Brpf3 Lgals3bp Lamp2 Tf Wdr1 Maged2 Endod1 Prkcb Serpina4 Habp4 Stx4 Cdc37l1 Igf2 Tagln2 App Itih4 Itih3 Nhlrc2 Fermt3 Lefty2 Thbs1 Manf Lefty1 Apoh Igf1 Gtpbp2 Orm1 Rab27b Ecm1 Ola1 Ctsw Actn4 Tmsb4x Plg Cd63 Tor4a F8 Tmx3 Scg3 Vcl Selp Cyrib Sccpdh Srgn Pecam1 Timp1 Pf4 Aplp2 Mmrn1 Pros1 Cd9 Plek Sod1 A2m BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME DATABASE ID RELEASE 97%10231454 Biosynthesis of DPAn-3-derived maresins Alox5 Alox12 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 97%10230668 SHC-related events triggered by IGF1R Grb2 Igf1r Sos1 Igf2 Shc1 Igf1 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231416 RHOV GTPase cycle Nck2 Pard6a Git1 Usp9x Rhov Wdr6 Cep97 Txnl1 Myo9a Pard6b Sh3rf1 Dst Arhgef7 Depdc1b Cltc Epha2 Cdc42 Peak1 Dlg5 Tpm4 Ccp110 Sptbn1 Pak4 Sptan1 Pik3r1 Arhgap12 Zfp512b Map3k11 Pak1 Pak6 Git2 Nck1 Pak2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%10228588 Transport of Mature mRNA Derived from an Intronless Transcript Nup58 Cpsf4 Nup37 Nup205 Pom121 Cpsf1 Cpsf2 Nup107 Sec13 Nup188 Cpsf3 Tpr Nup160 Rae1 Ndc1 Nup85 Ncbp2 Ncbp1 Nup42 Nup62 Nup43 Nup88 Sympk Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nxf1 Fip1l1 Eif4e Nup93 Nup50 Nup35 Alyref Nup54 Nup98 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231434 Biosynthesis of D-series resolvins Hpgd Alox5 Lta4h Gpx4 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 97%10228932 Removal of aminoterminal propeptides from gamma-carboxylated proteins Pros1 Bglap F7 Gas6 Proc F2 F10 Furin Proz F9 ETHANOL OXIDATION%REACTOME%R-RNO-71384.1 Ethanol oxidation Aldh2 Adh6 Adh4 Aldh1a1 Adh5 Adh1 Adh7 Aldh1b1 Acss2 Acss1 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229030 Lectin pathway of complement activation Fcn2 Fcn1 Colec10 Mbl2 Masp1 Masp2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Ncoa2 Akr1c18 Akr1c19 Hsd3b7 Cyp8b1 Akr1c1 Akr1d1 Cyp7b1 Nr1h4 Akr1c21 Akr1c9 Cyp27a1 Akr1c12l1 Akr1c3l1 Cyp7a1 Rxra Akr1c12 Akr1c13 ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%10231788 Error-prone mismatch repair hypermutates immunoglobulin genes Pold3 Rev1 Msh6 Msh2 Rps27a Pms2 Mlh1 Rev3l Poli Polh Ubb Ubc Exo1 Uba52 Rfc5 Pold2 Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly Gemin5 Snrpg Snrpb Nup58 Gemin8 Nup37 Nup205 Pom121 Prmt5 Nup107 Sec13 Nup188 Tgs1 Tpr Smn1 Nup160 Snupn Rae1 Ndc1 Snrpd1 Nup85 Clns1a Nup42 Nup62 Nup43 Gemin7l1 Nup88 Aaas Snrpd3 Nup214 Ranbp2 Gemin2 Nup155 Nup133 Nup210 Nup153 Ddx20 Snrpepl2 Wdr77 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes Actr1a Tubg1 Dynll1 Akap9 Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Csnk1d Cep192 Clasp1 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Cep43 Cep41 Ninl Ckap5 Tubb5 Hsp90aa1 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Pafah1b1 Nde1 Nedd1 Pcm1 Ssna1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 Gab1 Frs2 Frs3 Shc1 Fgf16 Fgf17 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf5 Fgf8 Fgf9 Pik3ca Pik3r1 Fgfr3 Nras Grb2 Kras Sos1 Hras Ptpn11 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-RNO-9009391.1 Extra-nuclear estrogen signaling Mmp2 Mmp9 Btc Strn Akt3 Prkcz Cav2 Akt2 Egfr Esr1 Esr2 Akt1 Igf1r Xpo1 Pdpk1 Prmt1 Foxo3 Mmp7 Mmp3 Zdhhc21 Sphk1 Pik3r1 Src Pik3r2 Pik3r3 Egf Tgfa Cdkn1b Mapk1 Hbegf Gnai2 Gnai1 Gnai3 Areg Calm3 Cav1 S1pr3 Shc1 Gnat3 Hsp90aa1 Pik3ca Ptk2 Uhmk1 Ereg Nras Nos3 Kras Hras Zdhhc7 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-RNO-9027276.1 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3cg Irs2 Epo Epor Pik3cb Gab1 Jak2 Pik3cd Pik3ca Lyn Pik3r5 Pik3r1 TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling Tbk1 Ulk1 Tab3 Ube2d2 Smpd2 Tab2 Smpd3 Tab1 Ikbke Chuk Optn Otulin Clip3 Sppl2b Adam17 Sppl2a Tnfrsf1a Rbck1 Sharpin Ikbkb Tnf Ube2d3 Usp21 Otud1 Traf1 Ube2d1 Spata2 Rnf31 Usp2 Usp4 Ikbkg Rack1 Cyld Rps27a Otud7b Map3k7 Ube2l3 Mib2 Traf2 Birc2 Fadd Uba52 Ripk1 Xiap Stub1 Tax1bp1 Nsmaf Ubb Ubc Casp8 Tradd Madd Cflar Mapkapk2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) Mapk7 Mapk1 Nab2 Ppp2r1b Ppp2r1a Chd4 Egr2 Mapk3 Sgk1 Mapk11 Ppp2cb Ppp2ca Vrk3 Rps6ka3 Rps6ka5 Rps6ka1 Rps6ka2 Ppp2r5d Dusp3 Dusp4 Srf Dusp7 Dusp6 Mapk14 Mapkapk2 Atf1 PROTEASOME ASSEMBLY%REACTOME%R-RNO-9907900.1 Proteasome assembly Psmb8 Psmd8 Psmd2 Psme2 Psme1 Psmb10 Psmg1 Psmd1 Psmg4 Psmg3 Adrm1 Psma4 Psmd10 Psma3 Pomp Psma6 Psmd5 Psmd4 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmb9 Psmd6 Psmb6l1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%10230522 Resolution of Sister Chromatid Cohesion Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Nup160 Nup85 Dync1li2 Nup43 Dync1li1 Xpo1 Ranbp2 Ppp2r5b Ppp2r5a Nup133 Ppp2r5e Itgb3bp Hdac8 Pafah1b1 Cdca5 Zw10 Pds5b Stag2 Stag1 Pds5a Smc1a Smc3 Wapl Rps27 Clip1 Kif18a Dync1h1 Ccnb2 Ccnb1 Plk1 Cdk1 Ccnb2-ps2 Dync1i2 Dync1i1 Nudc Sec13 Firrm Clasp1 Clasp2 Ppp2cb Spc24 Ppp2ca Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Ppp2r5d Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%10231720 Formation of the dystrophin-glycoprotein complex (DGC) Drp2 Sntg2 Utrn Megf11 Lama4 Dmd Sgcz Snta1 Sntb2 Sntb1 Agrn Sgce Sgcd Sgcb Sgca Dtna Dag1 Sgcg Dtnb Sspn ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-RNO-8963693.1 Aspartate and asparagine metabolism Slc25a13 Aspa Nat8l Got1 Got2 Gadl1 Folh1 Naalad2 Aspg Asns Slc25a12 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-RNO-453279.1 Mitotic G1 phase and G1 S transition Cdc25a Ccnh Ccnd1 Ppp2r1b Ppp2r1a Cdk4 Cdk7 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Psmd12 Pole4 Dbf4 Psmd11 Orc5 Orc4 Orc6 Psmd14 Orc1 Psmd13 Orc3 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Rpa1 Rpa2 Cdc7 Psmb7 Cdc6 Psmb6 Psmb1 Prim2 Rpa3 Cdk2 Psmb3 Psmb2 Prim1 Mcm3 Lyn Mcm4 Mcm5 Mcm10 Src Psma7 Pole Mcm2 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ppp2r2a Ptk6 Cdkn1b Tfdp2 Tfdp1 Psmd7 Psmd6 Psmd8 Psmd2 Rbbp4 Jak2 Rbl1 E2f4 Psmd1 E2f5 Adrm1 Lin52 Lin54 Lin37 E2f1 E2f2 E2f3 Ppp2r3b Dyrk1a Cdkn2b Cdkn2d Cables1 Skp2 Rb1 Cdkn1c Akt3 Hdac1 Akt2 Akt1 Rbl2 Lin9 Rps27a Abl1 Skp1 Ppp2cb Ppp2ca Uba52 Ccnd2 Ccne1 Ccne2 Ccnd3 Ccna1 Ccna2 Cks1b Cdk6 Ubb Mnat1 Ubc Wee1 Psmb6l1 AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229698 Agmatine biosynthesis Azin2 Agmat HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%10228712 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Pkn2 Gnas Calcrl Prkaca Prkacb P2ry2 Trpv4 Gna11 Akt1 Prkar1a Mapkap1 Prkar1b Calm3 Gng3 Gng5 Pdpk1 Gng4 Gnaq Gng7 Vcl Adm Gng8 Gngt1 Prkar2a Gnb2 Gnb1 Gnb4 Gnb3 Capn2 Gnb5 Gng11 Gng12 Nos3 Prr5 Mtor Capns1 Rictor Gng10-ps1 Mlst8 Ramp2 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 97%10228544 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-RNO-6804114.1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Bax Gadd45a Aurka Cdk1 Pcna Ccnb1 Sfn G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-RNO-416476.1 G alpha (q) signalling events F2rl1 Prokr2 Prokr1 Gpr65 Gpr68 Adra1b Adra1a Adra1d Uts2 Btk Tacr3 Tacr2 Anxa1 Casr Ffar3 Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Chrm1 Hrh1 Chrm3 Chrm5 Tac3 Tac1 Opn4 Pmch Trpc7 Lpar5 Trpc3 Itpr3 Itpr2 Ltb4r2 F2r F2 F2rl2 F2rl3 Lpar3 Lpar1 Oxt Trh Grm1 Grm5 Htr2a Htr2c Htr2b Lpar4 Prkch Ltb4r Nras Grb2 Qrfpr Kras Sos1 Hras Xcl1 Kiss1 Mgll Ccl9 P2ry6 Ccl6 P2ry2 P2ry1 Gast Hcrtr2 Hcrtr1 Dgka Dgkb Abhd6 Uts2b Dgkd Dgke Dgkg Cck Uts2r Dgkh Dgki Dgkk Dgkq Dgkz Daglb Dagla App Mapk7 Ffar4 Mapk1 Hbegf Ghrl Mapk3 Agtr1 Rps6ka3 Rps6ka1 Abhd12 Rps6ka2 Prkcq Egfr Mmp3 Plcb4 Plcb3 Plcb2 Plcb1 Gng10-ps1 Prkce Arhgef25 Prkcd Prkca Gna11 Gna14 Ednrb Gng3 Ednra Grk2 Npff Gng5 Gng4 Trio Gnaq Trhr Gng7 Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Avpr1b Avpr1a Tbxa2r Itpr1 Gnrh1 Nmbr Fpr2 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 Ptgfr Rgs3 Rgs17 Rgs1 Rgs16 Nmb Rgs21 Oxtr Rgs18 Lpar6 Rgs19 Kalrn Xcr1 Rgs13 Grpr Gpr17 Nms Nmu Cckar Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Pik3r1 Ptger1 Pik3r2 Pik3r3 Mchr1 Gpr132 Edn1 Edn2 Edn3 Cckbr Avp Gpr39 Hcrt Gpr143 Grp Kiss1r Gcgr Nps Ptafr Npffr1 Npffr2 Pik3ca Gprc6a Cysltr2 Cysltr1 Prok2 Qrfprl Gpr4 Gcg Tacr1 Qrfp Agt Npsr1 Prok1 P2ry10 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 97%10228736 PKA-mediated phosphorylation of CREB Adcy8 Adcy5 Prkar2a Adcy6 Adcy9 Prkaca Prkacb Prkar1a Prkar1b Calm3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 Nedd4 Hbegf Btc Rps27a Psenen Esr1 Egfr Psen1 Psen2 Ncstn Stat5a Aph1a Wwox Aph1b Uba52 Shc1 Wwp1 Yap1 Pik3ca Src Pik3r1 Ereg Egf Nras Ubb Grb2 Ubc Kras Erbb3 Sos1 Nrg2 Hras Nrg1 Nrg3 Itch GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation Adcy8 Adcy5 Kcnj15 Adcy6 Kcnj16 Adcy9 Gnai2 Gnai1 Gnai3 Kcnj3 Kcnj2 Gng3 Gnal Gng5 Gng4 Gng7 Gng8 Gngt1 Gnat3 Gnb2 Gnb1 Gabbr1 Gnb4 Gnb3 Gnb5 Gng11 Gabbr2 Gng12 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Kcnj10 Kcnj12 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230704 CLEC7A (Dectin-1) induces NFAT activation Nfatc1 Ppp3r1 Calm3 Ppp3ca Nfatc3 Nfatc2 Ppp3cb REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors Tp53 Phf20 Akt3 Akt2 Akt1 Zfp385a Tp73 Tp63 Banp Pou4f1 Ppp1r13l Ppp1r13b Pou4f2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex Ubb Traf6 Ubc Uba52 Rps27a Map3k7 Tab3 Tab2 Tab1 Irak2 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-RNO-975138.1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Cd14 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 IRS-MEDIATED SIGNALLING%REACTOME%R-RNO-112399.1 IRS-mediated signalling Akt2 Irs1 Irs2 Kl Gab1 Flt3 Fgf10 Frs2 Trib3 Fgf3 Fgf22 Fgf7 Pdpk1 Pik3c3 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Them4 Pik3cb Fgfr2 Pde3b Fgf6 Pik3r4 Fgf5 Fgf8 Gab2 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Pik3r1 Pik3r2 Fgfr3 Tlr9 Grb2 Sos1 Fgfr1 Ptpn11 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 97%10231328 Invadopodia formation Adam12 Adam19 Adam15 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%10228180 Transcriptional Regulation by TP53 Prkag1 Rad50 Cdc25c Prkag2 Npm1 Gls Eloa Topbp1 Rbbp8 Brca1 Sesn3 Mta2 Ywhae Mbd3 Rad1 Brpf1 Bnip3l Eloc Csnk2a2 Elob Steap3 Tp53rkb Tp53rka LOC134478826 Csnk2a1 Kat6a Ywhag Chd3 Gatad2a Gatad2b Csnk2b Ssrp1 Rffl Txn Cradd Pidd1 Tpx2 Tmem219 Tp63 Banp Gsr Ccnk Gpx2 Rbbp4 Ccng1 Ccnt2 Rbbp7 Smyd2 Prkab2 Prkab1 Cnot3 Ehmt1 Cnot2 Jmy Plk3 Btg2 Cnot1 Cnot7 Plk2 Cnot6 Cnot11 Tnks1bp1 Cnot4 Cnot9 Cnot8 Cnot6l Cnot10 Dyrk2 Cpap Prdx2 Prdx5 Mapkapk5 Cox7a2l Cox6a1 Cox6a2 Hdac2 L3mbtl1 Akt3 Daxx Hdac1 Akt2 Kmt5a Higd1c Akt1 Coxfa4 Cox6c2 Cycsl2 Noc2l Txnrd1 Tigar Cox6b1 Cox8a Hipk1 Cox6b2 Rabggta Rabggtb Cox8c Ppp1r13l Ppp1r13b Brpf3 Gls2 Stk11 Cox7b Ccnb1 G6pdx Cox4i1 E2f7 E2f8 Cox4i2 Cdk1 Mt-co3 Cox7c Mt-co2 Cycs Rnf34 Nuak1 Chm Usp2 Rps27a Cox7a1 Cox7a2 Sgk1 Cox5a Cox5b Mt-co1 Ppp2cb Ppp2ca Uba52 Tp73 Ttc5 Eloa2l Ccne1 Ccne2 Pou4f1 Pou4f2 Cdk5r1 Polr2c Polr2a Taf9 Polr2b Pml Map2k6 Meaf6 Polr2g Polr2h Polr2e Polr2f Mnat1 Ubb Mdm4 Prr5 Polr2i Zfp385a Taf9b Ubc Gadd45a Exo1 Polr2j Gpi Taf15 Rictor Taf11 Igfbp3 Taf10 Rfc5 Taf13 Taf12 Rfc3 Gtf2h2 Mapk14 Gtf2h1 Rfc4 Gtf2f2 Pcna Gtf2f1 Gtf2h3 Rfc2 Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Taf4b Pip4k2b Ppp2r1b Taf7l-ps1 Pip4k2c Ppp2r1a Pip4k2a Prmt5 Cdk7 Taf8 Taf7 Taf6 Taf5 Taf4 Nelfa Nelfb Cdk9 Taf2 Nelfe Mapkap1 Mapk11 Taf1 Ctdp1 Supt4h1 Nelfcd Brd7 Pdpk1 Rpa1 Rpa2 Tp53 Lamtor5 Rptor Rpa3 Cdk2 Lamtor3 Rraga Lamtor4 RragB Ep300 Lamtor1 Rragc Lamtor2 Rragd Casp2 Mtor Rheb Cdkn1b Mlst8 Slc38a9 Bax Usp7 Tcea1 Pip4p1 Cdk5 Ywhaq Ywhah Ywhab Sfn Aurka Chd4 Phf20 Mre11 Kat5 Nbn Hus1 Atrip Prdx1 Dna2 Blm Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Atm Atr Ccna1 Ccna2 Aurkb Rmi2 Rmi1 Sesn2 Sesn1 Brip1 Tsc2 Ddit4 Tsc1 Prkaa1 Cdk13 Cdk12 Ell Ywhaz Ing5 Ing2 Rhno1 Brd1 Wrn Prkag3 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%10230366 Erythrocytes take up carbon dioxide and release oxygen Cyb5r2 Aqp1 Cyb5r1 Cyb5rl Ca1 Ca2 Ca4 Hba1 Hbb Rhag Cyb5r4 Slc4a1 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%10231268 Transcriptional regulation by RUNX3 Ccnd1 Tgfb1 Psma4 Psma3 Psma6 Psma5 Psma2 Crebbp Psma1 Tcf7 Psmd12 Tcf7l1 Psmd11 Ctnnb1 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Psmb2 Ep300 Src Psma7 Psmc5 Psmc2 Kat2b Psmc1 Psmc4 Psmc3 Cbfb Psmd7 Smad4 Psmd6 Psmd8 Psmd2 Smurf2 Smurf1 Smad3 Tcf7l2 Rps27a Psmd1 Adrm1 Kat2a Maml3 Rbpj Hdac4 Lef1 Maml1 Runx3 Maml2 Uba52 Tead3 Tead2 Tead4 Yap1 Ubb Ubc Psmb6l1 ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors Adra1a Adra1d Adrb2 Adra2a Adrb1 Adra2c Adra1b Adrb3 Adra2b EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%10229658 EGFR interacts with phospholipase C-gamma Ereg Egf Plcg1 Tgfa Areg Hbegf Btc Egfr FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production Rbsn Jmjd1c Kif3a Kif3b Hdac2 Kif3c Hdac1 Kdm1a Kif21a Klc1 Kif21b Rab5a Klc4 Rac1 Klc3 Akap10 Ak3 Klc2 Kif18a Dock5 Cdc42 Kif18b Dock3 Maff Kif19 Dock4 Mafg Kif20a Kif20b Dock2 Kifap3 Kif11 H3-3b Kif12 Kif15 Kif1c Kif1a Kif1b Kif6 H2bc18 Sh2b2 Sh2b1 Kif9 Rad51c Dock6 Gata6 Rad51b Kifc1 Rcor1 Kifc2 Dock7 Kif22 Zfpm2 Dock8 Kif23 Kif28 Kif27 Jak2 Prkaca Kif16b Prkacb Racgap1 Akap1 Prkar1a Zfpm1 Gata1 Prkar1b Gata2 Dock10 Dock11 Vps45 Kif4b Kif26b Kif4a Prkar2a Kif26a Cbx5 Kif5a Kif5b Kif13b Itpk1 Mfn1 Gata5 Mfn2 Gata4 Hmg20b Kif2a Kif2b Kif2c Nfe2 Ehd1 Cenpe Ehd2 Gata3 Ehd3 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME%R-RNO-9840309.1 Glycosphingolipid biosynthesis B3galnt1 St3gal5 St3gal2 B4galnt1 Gal3st1 B3gnt5 St3gal3 St6galnac5 Ugt8 St6galnac6 Cerk B3galt4 Fut2 Fut1 Ugcg B4galt5 St8sia5 A4galt B4galt6 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-RNO-8849471.1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Bcar1 Elmo2 Elmo1 Rhoa Nras Arhgap35 Kras Rasa1 Crk Hras Ptk6 Pxn Rac1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-RNO-432047.1 Passive transport by Aquaporins Aqp1 Aqp9 Aqp8 Aqp7 Aqp11 Aqp5 Aqp4 Aqp3 Aqp2 Aqp12a Mip Aqp10 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-RNO-500753.1 Pyrimidine biosynthesis Cad Umps Dhodh FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-RNO-6781823.1 Formation of TC-NER Pre-Incision Complex Gtf2h5 Ercc2 Cops5 Ccnh Ercc3 Rps27a Cdk7 Znf830 Isy1 Xab2 Aqr Uba52 Usp7 Uvssa Tcea1 Ercc6 Cops7a Ppie Cops7b Cops3 Cops4 Cops6 Ddb1 Cul4a Gps1 Cops2 Polr2c Polr2a Polr2b Xpa Polr2g Cul4b Prpf19 Polr2h Polr2e Cops8 Polr2f Mnat1 Ubb Polr2i Ubc Polr2j Rbx1 Gtf2h2 Gtf2h1 Gtf2h3 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230002 NoRC negatively regulates rRNA expression H2bc6 H2bc4 Hist1h4m H2bc1 H2ac18 H2aj Hist1h2ai H2ab2 H3-3b Hist3h2ba H2ac4 Mbd2 H2bc18 Hist1h2bq H2az2 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%10229430 Degradation of beta-catenin by the destruction complex Ppp2r1b Csnk1a1 Ppp2r1a Cul1 Ctbp1 Ctbp2 Psma4 Psma3 Tle1 Psma6 Tle4 Psma5 Tle2 Psma2 Psma1 Tcf7 Psmd12 Tcf7l1 Psmd11 Ctnnb1 Psmd14 Psmd13 Ppp2r5b Ppp2r5a Psmb5 Amer1 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Apc Psmb3 Axin1 Psmb2 Gsk3b Frat2 Frat1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Tcf7l2 Rps27a Psmd1 Adrm1 Lef1 Skp1 Ppp2cb Ppp2ca Uba52 Btrc Ppp2r5d Tle3 Ubb Ubc Rbx1 Zranb1 Psmb6l1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-RNO-162699.1 Synthesis of dolichyl-phosphate mannose Dpm1 Dpm2 Dpm3 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism Slc38a1 Slc1a3 Slc1a2 Glul DAG1 GLYCOSYLATIONS%REACTOME%R-RNO-8931838.1 DAG1 glycosylations Mgat5b B4gat1 Pomt1 B3galnt2 Pomt2 Pomk Pomgnt2 Slc35a1 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Pomgnt1 Fktn DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 97%10230944 Dectin-2 family Clec6a-ps1 Fyn Plcg2 Syk Fcer1g Lyn Clec4d Clec4e MITOCHONDRIAL TRANSLATION%REACTOME DATABASE ID RELEASE 97%10230892 Mitochondrial translation Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Gadd45gip1 AC132020.1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Mt-cyb Ndufab1 Mt-co3 Mt-co2 Mief1 Mtrf1l Mt-atp8 Gfm1 Gfm2 Mrrf Mt-atp6 Mrps9 Mrps2 Mrps7 Mrps5 Mt-nd4l Dap3 Mrpl54 Mrpl55 Mt-co1 Mrpl58 Mrps30 Mt-nd5 Mrps31 Mrps33 Mt-nd4 Mrps34 Mt-nd6 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mt-nd1 Mrpl46 Mrpl48 Mtrf1 Mrpl49 Mrps21 Kgd4 Mrps22 Mt-nd3 Mrps23 Mrps24 Mrps25 Mt-nd2 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf5 Fgf8 Fgf9 Fgfr3 Nras Grb2 Kras Sos1 Hras Frs2 Frs3 Ptpn11 Fgf16 Fgf17 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%10231774 Assembly of the 9+2 motile cilia Grhl1 Gmnn Tp73 E2f4 E2f5 Grhl3 Gmnc Tfdp1 Mcidas Grhl2 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME DATABASE ID RELEASE 97%10231512 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Hmox1 Vamp2 Emd Ube2j2 Serp1 Sgta Stx5 Sec61gl4 Vapa Stx1a Cyb5a Prnp Aldh3a2 App CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%10228980 Cytoprotection by HMOX1 Tbl1x Cox7a2l Cox6a1 Cox6a2 Cox7a1 Cox7a2 Tgs1 Cox5a Cox5b Hba1 Hbb Mt-co1 Higd1c Coxfa4 Smarcd3 Crebbp Cox6c2 Ppara Cycsl2 Hdac3 Cox6b1 Cox8a Cox6b2 Tbl1xr1 Fabp1 Cox8c Blvrb Hmox1 Ncoa2 Sin3a Hmox2 Sin3b Blvra Abcc1 Ncor2 Hm13 Carm1 Cox7b Alb Med1 Cox4i1 Cox4i2 Mt-co3 Rxra Cox7c Mt-co2 Cycs CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%10229734 Class C 3 (Metabotropic glutamate pheromone receptors) Tas1r3 Tas2r40 Tas2r16 Tas2r13 Tas2r41 Tas2r135 Tas2r136 Tas2r140 Tas2r145 Tas2r105 Tas2r119 Tas2r107 Tas2r39 Tas2r38 Tas2r4 Grm1 Grm3 Tas2r3 Grm2 Grm5 Grm4 Tas2r7 Grm7 Gabbr1 Grm6 Grm8 Casr Gabbr2 Gprc6a Tas1r2 Tas2r120 Tas1r1 APAP ADME%REACTOME DATABASE ID RELEASE 97%10228906 APAP ADME Sult2a1 Sult2a6 Gstp1 Acy1a Sult1e1 Ggt1 Abcg2 Ugt1a1 Abcc3 Abcc1 Ugt2b15 Abcc4 Cyp2e1 Gstt1 Abcc2 Abcc5 Cndp2 Ugt1a6 Ugt1a7 Ugt1a8 Ggt5 Ggt7 Ggt6 Nat1 Nat2 Nat3 Sult1a1 Sult2a2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME DATABASE ID RELEASE 97%10228334 Detoxification of Reactive Oxygen Species Prdx2 Gpx2 Prdx5 P4hb Gpx1 Prdx3 Prdx6 Sod2 Gstp1 Cat Nox4 Cycsl2 Gpx3 Cyba Txnrd1 Gpx6 Gpx5 Gpx8 Cybb Gpx7 Nudt2 Txn2 Ero1a Txnrd2 Sod3 Ccs Ncf1 Txn Ncf2 Sod1 Ncf4 Prdx1 Gsr Cycs IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade Igf1 Akt2 Irs1 Irs2 Kl Igf1r Gab1 Flt3 Fgf10 Frs2 Trib3 Fgf3 Fgf22 Shc1 Fgf7 Pdpk1 Pik3c3 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Them4 Pik3cb Fgfr2 Pde3b Fgf6 Pik3r4 Fgf5 Fgf8 Gab2 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Pik3r1 Pik3r2 Fgfr3 Tlr9 Grb2 Sos1 Fgfr1 Igf2 Ptpn11 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%10231130 TP53 Regulates Transcription of Cell Death Genes Casp2 Bnip3l Chm Steap3 Cradd Pidd1 LOC134478826 Igfbp3 Tmem219 Atm Rabggta Rabggtb DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%10228412 Dimerization of procaspase-8 Traf2 Fadd Ripk1 Casp8 Tradd Fas Cflar Faslg Tnfsf10 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%10228534 RNA Polymerase III Transcription Initiation Tbp Brf1 Gtf3a Polr1c Pou2f1 Polr3a Brf2 Polr3d Snapc3 Polr3e Snapc4 Polr3b Snapc1 Polr3c Snapc2 Polr3f Polr3g Polr3gl Gtf3c2 Crcp Gtf3c1 Gtf3c4 Bdp1 Gtf3c3 Gtf3c6 Gtf3c5 Polr2h Polr2e Polr2f KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450604.1 KSRP (KHSRP) binds and destabilizes mRNA Exosc8 Exosc5 Khsrp Exosc4 Exosc7 Exosc6 Exosc1 Exosc3 Exosc2 Dcp2 Akt1 Dis3 Parn Ywhaz Exosc9 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231402 RHOJ GTPase cycle Arhgap1 Dock8 Arhgap21 Rhoj Ophn1 Syde1 Arhgap26 Arhgap32 Pik3r1 Pik3r2 Arhgap35 Ocrl Depdc1b Prex1 Trio Arhgap5 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231412 RHOBTB GTPase Cycle Srrm1 Rbbp6 Cpsf7 Actb Cul3 Txnl1 Cct7 Rbmx Tmod3 Ddx39b Actn1 Msi2 Cops4 Spen Phip Hsp90aa1 Rock2 Rock1 Stk38 Gps1 Myo6 Cops2 Cct2 Rhobtb2 Hnrnpc Cdc37 Rhobtb1 Pde5a Hsp90ab1 Rnf20 Cct6a Tra2b Twf1 Vim ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111448.1 Activation of NOXA and translocation to mitochondria Pmaip1 SIGNALING BY NTRK3 (TRKC)%REACTOME%R-RNO-9034015.1 Signaling by NTRK3 (TRKC) Ntrk3 Plcg1 Ntf3 Src B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230860 B-WICH complex positively regulates rRNA expression Tbp H2bc6 H2bc4 Hist1h4m H2bc1 Taf1d H2ac18 Taf1a Taf1c Kat2a Taf1b Hist1h2ai Sf3b1 Polr1b Polr1c Polr1a Polr1f Polr1g Polr1e Polr1h Ercc6 Mybbp1a Hist1h2bq Actg1 Gsk3b Myo1c Ep300 H2aj H2ab2 Polr2h Polr2e Smarca5 H3-3b Polr2f Hist3h2ba Kat2b Dek H2ac4 Ddx21 H2bc18 Baz1b H2az2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229930 Adrenaline,noradrenaline inhibits insulin secretion Gng8 Gngt1 Adcy5 Adcy6 Gnb2 Gnb1 Gnb4 Gnb3 Adra2a Gnai2 Gnb5 Gnai1 Gng11 Adra2c Gng12 Gng3 Gng10-ps1 Gng5 Gng4 Gng7 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%10230554 Synthesis of IPs in the ER lumen Minpp1 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%10231560 Sealing of the nuclear envelope (NE) by ESCRT-III Tubb2a Chmp2b Ist1 Tuba8 Tubb6 Tubb3 Tubb1 Vps4a Chmp3 Chmp4c Chmp7 Chmp6 Tuba1b Chmp4bl1 Tubal3 Spast Tuba4a Tuba3b Tubb4b Tubb4a Tuba1a Tuba1c Cc2d1b Chmp2a Tubb2b CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 97%10229728 Chemokine receptors bind chemokines Ccr10 Ccl20 Ccl21 Cxcl9 Ccl7 Ccl5 Ccrl2 Ccl4 Ccl3 Cxcr1 Xcr1 Cxcr2 Ccl1 Cxcr3 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Cxcl16 Cxcr4 Cxcl13 Cxcr5 Ccl19 Ackr3 Ccl17 Ackr4 Ccl11 Ackr2 Ccl12 Cxcl11 Cxcl12 Pf4 Cx3cl1 Cxcl10 Ccr9 Ccr8 Ccr7 Cx3cr1 Ccr6 Ccr5 Ccl27 Ppbp Ccr4 Ccr3 Xcl1 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 97%10230364 ER-Phagosome pathway Psmb8 Psme2 Psme1 Psmb10 RT1-M1-5 Rt1-ec3 Psma4 Psma3 Psma6 RT1-M6-2 Psma5 AABR07044308.1 Psma2 Psma1 Vamp3 B2m Pdia3 Vamp8 RT1-M10-ps5 Psmb4 Psmb7 Psmb6 Psmb3 RT1-N3 RT1-M5 Psma7 RT1-M2 Snap23 Psmb9 Psmb6l1 MTOR SIGNALLING%REACTOME%R-RNO-165159.1 MTOR signalling Prkag1 Prkag2 Akt3 Prkab2 Akt2 Prkab1 Pgk1 Akt1 Stk11 Lamtor5 Rptor Akt1s1 Lamtor3 Rraga Lamtor4 RragB Ywhab Lamtor1 Tsc2 Eef2k Rragc Tsc1 Prkaa1 Lamtor2 Fkbp1a Rragd Rps6 Eif4ebp1 Mtor Cab39 Eif4e Rheb Ppm1a Rps6kb1 Stradb Mlst8 Slc38a9 Strada Prkag3 Cab39l ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%10230494 Elastic fibre formation Fbln2 Itgb3 Fbln5 Efemp2 Tgfb1 Bmp7 Tgfb2 Tgfb3 Ltbp3 Ltbp2 Mfap4 Ltbp4 Mfap5 Ltbp1 Mfap2 Itgb8 Lox Furin Itgb1 Loxl2 Loxl1 Loxl4 Loxl3 Bmp4 Fbn1 Itga8 Bmp10 Vtn Itgb6 Itgav Bmp2 Gdf5 Eln HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism Amdhd1 Aoc1 Uroc1 Hal Carns1 Ftcd Carnmt1 Hdc TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Tirap Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 97%10229604 Vitamin D (calciferol) metabolism Ube2i Cyp24a1 Cubn Ldlrap1 Sumo3 Cyp27b1 Gc Lrp2 Vdr Pias4 Lgmn REGULATION OF INSULIN SECRETION%REACTOME%R-RNO-422356.1 Regulation of insulin secretion Cacna1e Cacna1a Adra2a Adra2c Marcks Rapgef4 Rapgef3 Abcc8 Rap1a Kcnb1 Kcns3 Plcb3 Ffar1 Plcb2 Plcb1 Cd36 Gng10-ps1 Kcnc2 Kcng2 Slc2a1 Adcy5 Adcy6 Gnas Prkaca Prkacb Cacna1c Gnai2 Gnai1 Prkca Gna11 Itpr3 Gna14 Itpr2 Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Cacna1d Gnb2 Gnb1 Gnb4 Gnb3 Slc2a2 Gnb5 Gng11 Gng12 Cacna2d2 Acsl3 Acsl4 Gcg Kcnj11 Cacnb3 Glp1r Itpr1 Cacnb2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-RNO-429958.1 mRNA decay by 3' to 5' exoribonuclease Exosc8 Nt5c3b Exosc5 Skic3 Skic2 Exosc4 Hbs1l Skic8 Exosc7 Exosc6 Exosc1 Exosc3 Exosc2 Dis3 Dcps Exosc9 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 97%10228864 APC C-mediated degradation of cell cycle proteins Skp2 Aurka Fbxo5 Cdc14a Rb1 Pttg1 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cdk2 Psmb2 Ccnb1 Psma7 Plk1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Nek2l1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Aurkb Anapc1 Anapc2 Btrc Fzr1 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%10229544 Formation of the beta-catenin:TCF transactivating complex Rbbp5 Tcf7l2 Hdac1 Pygo2 Tle1 Pygo1 Tle4 Kmt2b Lef1 Tle2 Crebbp Tcf7 Tcf7l1 Bcl9l Men1 Bcl9 Ctnnb1 Wdr5 Ash2l Cdc73 Tert Leo1 Ep300 Tle3 Smarca4 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-RNO-427975.1 Proton oligopeptide cotransporters Slc15a1 Slc15a4 Slc15a3 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%10228614 GRB2 events in EGFR signaling Ereg Nras Egf Grb2 Tgfa Kras Areg Hbegf Sos1 Btc Hras Egfr SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-RNO-422085.1 Synthesis, secretion, and deacylation of Ghrelin Gh1 Ghrl Pla2g7 Spcs3 Ins1 Spcs1 Spcs2 Ins2 Igf1 Pcsk1 Bche Lep Gcg Sec11c Sec11a Mboat4 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic Arfgap3 Copa Arfgap2 Arfgap1 Kif3a Kif3b Nbas Kif3c Use1 Copb2 Rab1b Arf1 Copb1 Cope Kif21a Klc1 Kif21b Bnip1 Napa Klc4 Klc3 Klc2 Kif18a Kif18b Kif19 Kdelr2 Kdelr3 Kif20a Kif20b Kifap3 Tmed9 Kif11 Kif12 Kif15 Kif1c Kif1a Kif1b Kdelr1 Kif6 Arf4 Kif9 Arf3 Kifc1 Stx18 Kifc2 Kif22 Kif23 Kif28 Tmed10 Kif27 Kif16b Racgap1 Gbf1 Tmed2 Tmed3 Copg1 Rint1 Copg2 Tmed7 Rab1A Copz2 Kif4b Kif26b Copz1 Kif4a Arf5 Kif26a Nsf Napb Kif5a Kif5b Kif13b Zw10 Napg Kif2a Kif2b Kif2c Arcn1 Cenpe TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230254 TRAF6 mediated IRF7 activation Crebbp Irf7 Irf3 Ep300 AMINO ACID CONJUGATION%REACTOME%R-RNO-156587.1 Amino Acid conjugation Glyat Glyatl3 Acsm2 Acsm4 Acsm5 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231646 Transcriptional and post-translational regulation of MITF-M expression and activity Tbx3 Mapk1 Mapk3 Akt3 Hint1 Aimp2 Crebbp Sirt1 Lars1 Csf1 Mark3 Xpo1 Sox10 Kars1 Rps6ka1 Mars1 Dars1 Kit Tnfsf11 Gsk3b Mitf Ep300 Qars1 Ube2i Sumo1 Kitlg Eprs1 Rars1 Iars1 MRNA 3'-END PROCESSING%REACTOME%R-RNO-72187.1 mRNA 3'-end processing Snrpg Snrpb Snrpd1 Ncbp2 Ncbp1 Snrpd3 Snrpepl2 Ppp1ca Phf5a Smndc1 Hnrnpr-ps2 Prpf40a U2surp Cdc40 Pcbp2 Pcbp1 Sympk Clp1 Hnrnpr Dhx9 Hnrnpu Snrpa1 Rbm10 Ptbp1 Sugp1 Hnrnpc Hnrnpd Hnrnpf Hnrnpk Hnrnpl Pcf11 Cstf1 Nudt21 Cstf2 Dhx15 Cstf3 Srsf19 Srsf11 Srsf12 Tut1 Srrm2 Sf3a1 Sf3a2 Sf3a3 Ppp1cb Sf3b1 Sf3b3 Sf3b4 Sf3b5 Hnrnph2 Hnrnph1 Hnrnpa2b1 Srrt Snrnp70 Htatsf1 Papolg Ppp1r8 Fip1l1 Papola Snrpa Snrpc Snrpn Cherp Fus Cpsf4 Cpsf6 Cpsf7 Rbbp6 Rbm25l1 Cpsf1 Cpsf2 Rps27a Cpsf3 Prr3 Rbmx Ybx1 Dnajc8 Rbm25 Uba52 Srsf1 Rbm5 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Rbm17 Ddx46 Ddx42 Puf60 Polr2c Polr2a U2af1 Polr2b Polr2g Polr2h Hnrnpa1 Polr2e Polr2f Ubb Cstf2t Polr2i Ubc U2af1l4 Polr2j Tcerg1 Tra2b Pabpn1 Snrpf Gtf2f2 Gtf2f1 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%10228202 Cellular responses to stimuli Rad50 Dynll1 Dynll2 Egln1 Egln2 Cdk4 Egln3 Epas1 H2ac18 Hif3a Cul3 Ube2d2 Ezh2 Hif1an Psma4 Wtip Psma3 Ajuba Hif1a Psma6 Cited2 Psma5 Ywhae Vhl Psma2 Limd1 Psma1 Cul2 Eloc Elob Atp6v0b Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Atp6v1g3 Atp6v0e2 Atp6v1c2 Psmb5 Atp6v1c1 Psmb4 Keap1 Atp6v0c Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Atp6v1e2 Gsk3b Atp6v1e1 Tcirg1 H2aj Atp6v1a Atp6v1b2 Psma7 Atp6v0d2 H3-3b Psmc5 Atp6v0d1 Hist3h2ba Atp6v1b1 Psmc2 Atp6v0e1 Psmc1 Atp6v1g2 Psmc4 Atp6v1g1 Psmc3 Atp6v1f Ppp2r2a Atp6v1d H2bc18 Psmd7 Slc46a1 Psmd6 Ube2d3 H2az2 Psmd8 Psmd2 Ube2d1 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Psmd1 Adrm1 Hist1h2ai Ptpn1 Nploc4 Ufd1 Ehmt1 Nfe2l2 Alb Ptk2 Mt2 Mt3 Cox7a2l Cox6a1 Cox6a2 Hspa5 Higd1c Coxfa4 Cox6c2 Sirt1 Cycsl2 Hspa9 Cox6b1 Cox8a Cox6b2 Mul1 Cox8c Anxa2 Cox7b Cox4i1 Cox4i2 Mt-co3 Cox7c Mt-co2 Cycs Trim21 Cox7a1 Cox7a2 Cox5a Cox5b Mt-co1 Trpv4 Ppara Clec1b Vcl Hsp90aa1 Ern1 Prr5 Ncf1 Ncf2 Sod1 Ncf4 Hsp90ab1 Rictor Nup93 Rxra Itgav Nup50 Pgr Nup35 Nup54 Nup98 Itgb3 Tbl1x Nup58 Nup37 Nup205 Hsph1 Pom121 Prdx3 Rps19bp1 Nup107 St13 Nup188 Prdx6 Tgs1 Bach1 Tpr Nox4 Cryab Nup160 Esr1 Hsbp1 Erf Rae1 Ndc1 Bag5 Bag3 Mapkap1 Crebbp Nup85 Bag2 Bag1 Gpx3 Nup42 Cyba Gpx6 Nup62 Gpx5 Nup43 Hdac3 Gpx8 Cybb Nup88 Gpx7 Aaas Cebpb Xpo1 Hspa14 Pdpk1 Hspa13 Nup214 Ranbp2 Id1 Tbl1xr1 Hikeshi Nup155 Foxo3 Hsf1 Nup133 Nudt2 Nup210 Ubxn7 Nup153 Ets1 Ets2 Fkbp4 Ero1a Abcc1 Fkbp5 Hspb8 Ptges3 Tp53 Hspa4 Lamtor5 Dnajc2 Rptor Txnrd2 Akt1s1 Dnaja2 Ncor2 Lamtor3 Dnaja4 Rraga Carm1 Dnaja1 Lamtor4 Hspa12b Ep300 RragB Hspa12a Lamtor1 Dnajb6 Dnajb1 Rragc Sod3 Lamtor2 Ccs Rragd Mtor Rheb Cdkn1b Mlst8 Slc38a9 Nos3 Rb1 Arnt Adm Ncoa2 Med1 Prdx1 Srxn1 Calcrl Stat1 Sqstm1 Mios Depdc5 Fnip1 Fnip2 Samtor Szt2 Castor2 Castor1 Sesn2 Sesn1 Capn2 Kics2 Itfg2 Wdr24 Nprl3 Nprl2 Flcn Wdr59 Sh3bp4 Ep400 Capns1 H1-1 H1-0 Asf1a H1-5 Cabin1 H1-4 Hira H4f3 Ubn1 Ramp2 Hmga2 Hmga1 P4hb Lmnb1 Txn Gsr Hspa8 Gpx2 Gnas Gpx1 Cat Nr3c2 Nr3c1 Atf6b Mbtps1 Txn2 Ar Apoa1 Eif2s3 Eif2s2 Eif2s1 Eef1a1 Map3k5 Tnik Cdkn2b Cdkn2d Actr1a Mink1 Prdx2 Map4k4 Prdx5 Mapkapk5 Dctn1 Dctn2 Akt3 P2ry2 Hba1 Hbb Akt2 Dctn4 Akt1 Txnrd1 Fabp1 Blvrb Hmox1 Hmox2 Blvra Mapk9 Ikbkb Mapk7 Mapk8 Mapk1 Ikbkg Rps27a Eif2ak3 Hspa2 Mapk3 Sirt3 Sod2 Nfkb1 Camk2a Skp1 Ppp2ca Uba52 Ring1 Fos Hspa1b Ube2s Phc2 Hspa1a Ccne1 Ccne2 Cbx6 Ube2c Rela Phc1 Ly96 Cdc27 Cdc26 Cbx4 Rps6ka3 Cdc23 Hspa1l Cbx2 Phc3 Anapc10 Anapc16 Cdk6 Anapc15 Rps6ka1 Sin3a Anapc5 Sin3b Anapc4 Bmi1 Anapc1 Rps6ka2 Anapc2 Fzr1 Btrc Tlr4 Anapc7 Ube2e1 Cdc16 Yap1 Rnf2 Actr10 Map2k7 Map2k6 Mdm4 Ubb Ubc Mapkapk3 Mapk14 Jun Mapkapk2 Nfkbia Map2k3 Ppp2r1b Ppp2r1a Cul1 Ikbke Chuk Mapk10 Smarcd3 Mapk11 Dync1li2 Dync1li1 Pgrmc2 Terf2 Terf1 Tinf2 Rpa1 Rpa2 Acd Terf2ip Rpa3 Cdk2 Hm13 Pot1 Prkci Gng10-ps1 Prkaca Prkacb Gna11 Prkar1a Map1lc3b Prkar1b Calm3 Gng3 Gng5 Gng4 Itgb1 Gnaq Gng7 Pde4d Gng8 Gngt1 Prkar2a Stip1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Pkn2 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Apob Dync1h1 Mre11 Kat5 Nbn Creb3l3 Crebrf Dync1i2 Atf6 Camk2g Camk2d Camk2b Dync1i1 Kdm6b Abl1 Sec13 Oma1 Gstp1 Atm Ccna1 Ccna2 H2ab2 H2ac4 Rbx1 Vcp Psmb6l1 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229630 DAP12 signaling Lat B2m Shc1 Klrk1 Rac1 Vav3 Plcg1 Plcg2 Pik3cb Btk Vav2 Syk Pik3ca Trem2 Pik3r1 Pik3r2 Lcp2 Tyrobp Nras Grb2 Fyn Kras Sos1 Hras Klrd1 Klrc2 Klrc1 Lck Grap2 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 Mecp2 Sin3a Hdac2 Hdac1 Lbr PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229894 Prostanoid ligand receptors Ptgir Tbxa2r Ptgdrl Ptgfr Ptger4 Ptgdr2 Ptger2 Ptgdr Ptger3 Ptger1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-RNO-1799339.1 SRP-dependent cotranslational protein targeting to membrane Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Srp68 Rplp0 Rplp1 Srp9 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Srp54 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a Srp14 Srp19 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 97%10230616 Hyaluronan metabolism Hyal1 Gusb Hyal2 Slc17a5 Chp1 Hexa Chp1l1 Hexb Has1 Abcc5 Has2 Has3 Cemip Slc9a1 Hyal5 Hyal4 Hyal3 Cd44 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism Txnrd1 Sephs2 Mat1a Scly TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 Lbp Cd14 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 97%10230568 Signaling by NOTCH Rps27a Jag2 Dll1 Dll4 Psenen Egfr Tmed2 Psen1 Akt1 Psen2 Ncstn Ybx1 Aph1a Aph1b Uba52 Notch3 Wwp2 Jag1 Elf3 Prkci Egf Ubb Ubc Ywhaz Adam10 Itch Dtx2 Dtx4 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-RNO-1606322.1 ZBP1(DAI) mediated induction of type I IFNs Nkiras2 Dhx9 Nfkbia Ikbkg Irf3 Myd88 Nfkb2 Nfkb1 Chuk Nfkbib Nkiras1 Rela Ikbkb COBALAMIN (CBL) METABOLISM%REACTOME%R-RNO-9759218.1 Cobalamin (Cbl) metabolism Mmab Mtr Mmadhc Mtrr Mmachc Mmut Mmaa SIGNALLING TO ERKS%REACTOME%R-RNO-187687.1 Signalling to ERKs Shc2 Mapk1 Rapgef1 Mapk3 Mapk11 Ntrk1 Frs2 Ngf Braf Shc1 Kidins220 Map2k1 Ralgds Rap1a Ywhab Shc3 Nras Grb2 Kras Sos1 Crk Hras Map2k2 Mapkapk3 Mapk14 Mapkapk2 Crkl TRANSPORT AND METABOLISM OF PAPS%REACTOME DATABASE ID RELEASE 97%10229212 Transport and metabolism of PAPS Papss1 Slc26a11 Slc35b3 Slc35b2 Slc26a2 Slc26a1 Papss2 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10230642 NOTCH3 Activation and Transmission of Signal to the Nucleus Jag2 Jag1 Rps27a Dll1 Dll4 Psenen Egfr Psen1 Egf Psen2 Ubb Ncstn Ybx1 Aph1a Ubc Aph1b Uba52 Notch3 Adam10 Wwp2 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%10230674 The retinoid cycle in cones (daylight vision) Dhrs3 Rbp3 Opn1mw Rlbp1 Opn1sw Awat2 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 97%10231042 Negative regulation of MAPK pathway Mapk1 Ppp2r1b Raf1 Ppp2r1a Rps27a Mapk3 Mapk12 Ppp2cb Ppp2ca Uba52 Mark3 Braf Ppp2r5b Map2k1 Ppp2r5a Ppp5c Ppp2r5e Ppp2r5d Ywhab Ptpn7 Ksr1 Brap Paqr3 Dusp4 Araf Dusp16 Nras Pebp1 Ubb Dusp10 Ubc Kras ENSRNOG00000069024 Dusp7 Dusp6 Hras Dusp5 Map2k2 Dusp1 Dusp9 Ptpn3 Dusp8 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%10228336 Cellular response to chemical stress Tbl1x P4hb Prdx3 Cul1 Prdx6 Cul3 Tgs1 Bach1 Nox4 Psma4 Psma3 Psma6 Psma5 Crebbp Psma2 Smarcd3 Psma1 Cyba Gpx3 Gpx6 Gpx5 Cybb Hdac3 Gpx8 Psmd12 Gpx7 Psmd11 Tbl1xr1 Psmd14 Psmd13 Nudt2 Ubxn7 Psmb5 Keap1 Psmb4 Ero1a Abcc1 Psmb7 Psmb6 Psmb1 Txnrd2 Psmb3 Hm13 Psmb2 Ncor2 Gsk3b Carm1 Ep300 Prkci Psma7 Sod3 Psmc5 Ccs Txn Psmc2 Psmc1 Psmc4 Psmc3 Gsr Psmd7 Psmd6 Psmd8 Psmd2 Gpx2 Gpx1 Psmd1 Cat Adrm1 Map1lc3b Nploc4 Ufd1 Nfe2l2 Txn2 Alb Prdx2 Prdx5 Cox7a2l Cox6a1 Cox6a2 Akt3 Hba1 Hbb Akt2 Higd1c Akt1 Coxfa4 Cox6c2 Cycsl2 Txnrd1 Cox6b1 Cox8a Cox6b2 Mul1 Cox8c Fabp1 Blvrb Hmox1 Ncoa2 Hmox2 Blvra Cox7b Med1 Cox4i1 Cox4i2 Mt-co3 Cox7c Prdx1 Mt-co2 Srxn1 Cycs Trim21 Rps27a Cox7a1 Cox7a2 Cox5a Sod2 Gstp1 Cox5b Mt-co1 Sqstm1 Skp1 Ppara Uba52 Sin3a Sin3b Btrc Sesn2 Sesn1 Ubb Ncf1 Ncf2 Ubc Sod1 Ncf4 Rbx1 Rxra Vcp Psmb6l1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 97%10228682 G alpha (i) signalling events P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 Tas2r40 Fpr2l1 Tas2r41 Hcar1 Adra2a Adra2c Adra2b Hcar2 Cxcr1 Cxcr2 Cxcr3 Npy1r Cxcr4 Cxcr5 Oprl1 Anxa1 Cxcl11 Hebp1 Cxcl12 Casr Cxcl10 C5ar1 Aplnr Bdkrb2 Bdkrb1 Kng1 Hrh4 Chrm4 Drd3 Drd4 Opn3 Pmch Gper1 Oxgr1 Lpar5 Opn5 Sucnr1 Pyy Adora1 Adora3 Rln3 S1pr3 Cxcl16 S1pr2 Cxcl13 S1pr5 S1pr4 Tas2r119 Lpar3 Opn1sw Lpar1 Npy5r Grm3 Grm2 Grm4 Grm7 Grm6 Grm8 Npy4r Cx3cr1 Psap Htr1d Htr1f Tas2r120 Htr1b Ccl9 Cxcl9 P2ry4 Ccl6 Ccl5 Ccl4 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Tas2r105 Tas2r107 Gpr37l1 Ackr3 Cnr1 Cnr2 Sst Oprk1 App Mapk1 Ppp2cb Gnat2 Ppp2ca Rgs7 Ppp2r5d Ppp2r1b Ppp2r1a Chrm2 Src Plcb4 Plcb3 Pla2g4a Pdyn Plcb2 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Gng3 Grk2 Gnal Pomc Rrh Gng5 Gng4 Pde4c Apln Gnaq Gng7 Tas2r39 Pde4d Gng8 Oprd1 Gngt1 Gnat3 Tas2r38 Prkar2a C3ar1 Cdk5 Pde1b Galr2 Pde1c Galr3 Gnb2 Galr1 Pde1a Gnb1 Sstr5 Gnb4 Sstr4 Gnb3 Sstr3 Gnb5 Gng11 Sstr2 Gng12 Sstr1 Rgs9 Rxfp3 Gnat1 Htr5a Gpr183 Ppbp Fpr1 Tas1r2 Tas1r1 Fpr2 Ccr10 Tas1r3 C3 Rgs4 Rgs5 C5 Rgs20 Rgs3 Rgs17 Pnoc Rgs1 Rgs16 Tas2r16 Rgs8 Tas2r13 Pcp2 Ppy Gpsm3 Tas2r135 Gpsm2 Gpsm1 Tas2r136 Rgs21 Rgs18 Rgs19 Rgs13 Gpr18 Rgs14 Rgs12 Gpr17 Ccr1l1 Nms Tas2r140 Nmu Tas2r145 Npbwr1 Nmur2 Nmur1 Tas2r4 Tas2r3 Tas2r7 Gabbr1 Ptger3 Gabbr2 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Mtnr1b Agtr2 Gpr37 Gal Penk Rgr Npb Opn1mw Ccl19 Ccl11 Npw Npy Ptgdr2 Rho Pf4 Cx3cl1 Fpr2l3 Ccl27 Agt RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%10231344 RUNX3 regulates p14-ARF Hdac4 Runx3 Ccnd1 Cbfb Tgfb1 Ep300 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-RNO-9634635.1 Estrogen-stimulated signaling through PRKCZ Nras Mapk1 Kras Hras Pdpk1 Prkcz TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%10228976 Telomere Maintenance Pold3 Pola2 Pola1 Chtf8 Terf2 Terf1 Tinf2 Rpa1 Chtf18 Rpa2 Ppp6r3 Ctc1 Stn1 Prim2 Tert Acd Terf2ip Rpa3 Ten1 Cdk2 Dscc1 Prim1 Pot1 Dna2 Blm Ppp6c Ankrd28 Ccna1 Ccna2 Shq1 Dkc1 Nhp2 Pif1 Fen1 Gar1 Lig1 Wrap53 Nop10 Rtel1 Pold1 Pold4 Rfc5 Pold2 Rfc3 Rfc4 Wrn Pcna Rfc1 Rfc2 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228236 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Pfkfb4 Pfkfb3 Pfkfb2 Pfkfb1 DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions Dscaml1 Dscam FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Tgfbr3 Kl Gipc1 Fgfr1 Fgf10 Fgf3 Fgf22 Fgf17 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling Jak3 Tyk2 Jak2 Il4r Stat3 Stat1 Socs1 Il13ra2 Socs5 Hsp90b1 Stat6 Il13 Il4 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231574 RND3 GTPase cycle Cpd Vangl2 Muc13 Wdr6 Txnl1 Picalm Scrib Ckb Rbmx Ccdc88a Ptpn13 Nisch Arhgap35 Tmod3 Dst Dsp Depdc1b Cav1 Fam83b Ubxn11 Kctd13 Epha2 Ktn1 Arhgap5 Plekhg5 Ddx4 Rnd3 Dlg5 Ankrd26 Dsg1 Arhgap21 Rock1 Tnfaip1 Ckap4 Sema4f Pik3r1 Pik3r2 Flot2 Rasal2 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%10230090 RHO GTPases activate PAKs Cdc42 Pak1 Calm3 Mylk Ppp1r12b Ppp1r12a Flna Rac1 Ppp1cb Pak2 Limk1 Pak3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-RNO-168164.1 Toll Like Receptor 3 (TLR3) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Irf3 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Rps6ka5 Rps6ka1 Tifa Rps6ka2 Irf7 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-RNO-433692.1 Proton-coupled monocarboxylate transport Slc16a3 Slc16a8 Slc16a1 Bsg Emb Slc16a7 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-RNO-110331.1 Cleavage of the damaged purine Terf2 Terf1 H2bc6 Tinf2 Neil3 H2bc4 Hist1h4m Acd H2bc1 Terf2ip H2ac18 Pot1 H2aj Hist1h2ai H2ab2 Mpg Hist3h2ba Ogg1 H2ac4 Mutyh Hist1h2bq H2az2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 97%10228918 Recycling of bile acids and salts Ncoa2 Baat Abcc3 Slc10a1 Nr1h4 Fabp6 Stard5 Slco1b2 Alb Slc27a5 Slc51a Slc51b Abcb11 Rxra Slco1a4 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-RNO-6806667.1 Metabolism of fat-soluble vitamins Rdh11 Ubiad1 Lpl Apoc2 Akr1c3l1 Apoc3 Apoa2 Sdc1 Sdc2 Apoe Vkorc1 Apoa4 Apob Akr1c1 Akr1c9 Akr1c12l1 Gpihbp1 Akr1b10 Lrp1 Sdc4 Sdc3 Lrp8 Lrp10 Plb1 Ttpa Lrp12 Ttr Gpc1 Gpc3 Gpc2 Bco2 Gpc4 Bco1 Gpc6 Agrn Clps Pnlip Rbp4 Lrp2 Apom Rbp2 Rbp1 Lrat Akr1c18 Akr1c19 Akr1c21 Vkorc1l1 Apoa1 Gpc5 Akr1c12 Akr1c13 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-RNO-5668599.1 RHO GTPases Activate NADPH Oxidases Mapk1 Pik3r4 Nox3 Mapk3 Prkcd S100a9 Nox1 S100a8 Prkcz Noxa1 Rac2 Prkca Mapk11 Ncf1 Ncf2 Prkcb Cyba Ncf4 Cybb Noxo1 Mapk14 Rac1 Pik3c3 ASPIRIN ADME%REACTOME%R-RNO-9749641.1 Aspirin ADME Glyat Ces2h Ugt2a1 Ugt2a3 Ugt2b1 Cyp3a9 Slco2b1 Ugt1a2 Ugt1a3 Ugt1a5 Ugt3a1 Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Ugt2b34l1 Ugt2b Ugt1a1 Ugt2b17 Abcc3 Cyp2c66 Cyp2c11 Ugt2b15 Cyp2e1 Abcc2 Glyatl3 Bche Alb Ugt1a6 Ugt1a7 Ces1d Ugt1a8 Cyp2d4 Ugt2b37 Slc16a1 Acsm2 Bsg Acsm4 Acsm5 AC114845.1 Slc22a7 Ugt2b7 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-RNO-2046105.1 Linoleic acid (LA) metabolism Acsl1 Elovl2 Elovl3 Elovl5 Elovl1 Fads2 Abcd1 Fads1 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 97%10230452 Acyl chain remodelling of PC Plb1 Pla2g6 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g4b Pla2g12a Lpcat3 Lpcat4 Pla2g10 Plaat3 Pnpla8 Pla2g5 Pla2g3 Tmem86b Mboat2 Pla2g4a Lpcat1 Lpcat2 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME%R-RNO-5654228.1 Phospholipase C-mediated cascade; FGFR4 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Fgf16 Fgf17 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%10230030 mRNA decay by 5' to 3' exoribonuclease Edc4 Patl1 Lsm3 Lsm5 Dcp1b Lsm1 Lsm6 Dcp2 Lsm7 Dcp1a Ddx6 Edc3 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 97%10228934 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Pros1 Ggcx Bglap F7 Gas6 Proc F2 F10 Furin Proz F9 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-RNO-9032500.1 Activated NTRK2 signals through FYN Dock3 Fyn Ntrk2 Bdnf Rac1 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228240 Glycogen synthesis Ppp1r3c Gbe1 Pgm1 Ugp2 Gys1 Gyg1 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-RNO-9839406.1 TGFBR3 regulates activin signaling Acvr2a Inhba Inha Tgfbr3 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229924 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Gna11 Plcb3 Gna14 Ffar1 Plcb2 Plcb1 Gnaq PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229228 Plasma lipoprotein assembly Apoc4 Sar1b P4hb Prkaca Prkacb Apoa1 Abca1 Mttp Apoc2 Apoc3 Bmp1 Apoa2 A2m Zdhhc8 Apoe Apoa4 Apoc1 Apob ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229392 Androgen biosynthesis Hsd3b Cyp17a1 Hsd3b6 Hsd3b5 Hsd3b1 Hsd3b5-ps1 Srd5a3 Srd5a1 Srd5a2 Cga Hsd17b12 Hsd17b3 Lhb Pomc DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-RNO-1614558.1 Degradation of cysteine and homocysteine Txn2 Suox Slc25a10 Gadl1 Sqor Ado Usf1 Fmo1 Ethe1 Mpst Cth Cdo1 Tst MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228628 MAPK1 (ERK2) activation Il6st Mapk1 Tyk2 Jak2 Il6r Map2k2 Ptpn11 Il6 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 97%10228360 Ribosomal scanning and start codon recognition Rps25 Rps26 Rps27 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Rps15a Rps4x-ps13 Rps3a Rps27l Eif4e Eif5 Eif1ax Eif4a2 Rps26-ps13 Eif4a1 Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Rps14 Eif3h Rps15 Eif3g Eif3b Rps16 Eif3a Eif3d Rps17 Eif3c Rps18 Rps19 Rpsa Uba52 Rps10 Rps11 Rps3 Rps2 Rps13 Rps4x Rps9 Rps7 Eif2s3 Rps8 Eif2s2 Rps5 Eif2s1 Rps6 Fau CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 97%10228542 Cytochrome P450 - arranged by substrate type Cyp24a1 Arnt Ahr Cyp39a1 Cyp19a1 Ncoa2 Cyp11a1 Cyp1b1 Ahrr Cyp2u1 Cyp51a1 Cyp2c66 Cyp2c11 Cyp8b1 Cyp7b1 Cyp2e1 Nr1h4 Cyp1a1 Cyp4v2 Cyp21 Cyp1a2 Cyp46a1 Cyp2w1 Cyp27a1 Arnt2 Cyp11b1 Fdx1 Cyp11b3 Cyp11b2 Fdxr Fdx2 Cyp7a1 Cyp26c1 Cyp27b1 Cyp3a9 Tbxas1 Ptgis Cyp3a18 Cyp3a1 Cyp3a62 Cyp3a2 Cyp2s1 Pomc Cyp2c24 Cyp2j16 Cyp4f39 Cyp26b1 Adh7 Cyp2j3 Cyp4f1 Cyp2f2 Cyp4a14 Cyp2b1 Cyp4f3 Cyp4f40 Cyp4a12 Cyp4b1 Cyp2a2 Cyp4f4 Cyp4a10 Cyp2a1 Cyp2d4 Cyp4a2 Cyp2a3 Rxra Cyp26a1 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-RNO-9758274.1 Regulation of NF-kappa B signaling Traf6 Nlrx1 Ikbkg Rps27a Usp14 Usp18 Lrrc14 Nlrc5 Traf2 Chuk Ubb Ubc N4bp1 Uba52 Casp8 Ikbkb REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction Catsper4 Catsperb Acr Catsper2 Izumo4 Hvcn1 Izumo3 Catsper3 Izumo2 Dmc1 Catsper1 Izumo1 Kcnu1 Fignl1 Firrm Cd9 Hyal5 Catsperg Rad51 Catsperd HYPUSINYLATION%REACTOME DATABASE ID RELEASE 97%10229596 Hypusinylation Dhps Eif5a Eif5a2 Dohh ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%10230788 Attenuation phase Hspa8 Fkbp4 Hsp90aa1 Ptges3 Hspa2 Ep300 Dnajb1 Hsbp1 Crebbp Hsp90ab1 Hspa1b Hspa1a Hspa1l Hsf1 NTRK2 ACTIVATES RAC1%REACTOME%R-RNO-9032759.1 NTRK2 activates RAC1 Dock3 Fyn Ntrk2 Bdnf Rac1 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%10230202 The NLRP1 inflammasome Bcl2l1 Nlrp1a P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis Rtn4 Ngf Arhgdia Omg Mag Ngfr Mcf2 Rhoa RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation Rab31 Rab4b Rab35 Rab36 Rab38 Rab1b Rab11b Rab11a Rab5a Rab4a Rabggta Rabggtb Rab5c Rab7a Rab33b Rab7b Rab33a Rab3a Rab6b Rab6a Rab5b Chm Rab27a Rab9a Rab39a Rab9b Rab27b Rab44 Rab2b Rab34 Rab37 Rab21 Rab8b Rab20 Ptp4a2 Rab8a Rab23 Rab26 Rab25 Rab1A Rab29 Rab40b Rab10 Rab15 Rab13 Rab17 Rab12 Rab19 Rab14 Rab3c Rab3b Rab18 Rab3d Rab2a Chml Rab43 FRS2-MEDIATED ACTIVATION%REACTOME%R-RNO-170968.1 Frs2-mediated activation Mapk1 Rap1a Ntrk1 Rapgef1 Frs2 Ngf Map2k2 Braf Mapk3 Ywhab Map2k1 Crkl INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions Itgb3 Madcam1 Lum Jam3 Jam2 Vcam1 Fn1 Fgb Itgb8 Fga Fgg Cdh1 Itga2b Itga6 Col4a4 Fbn1 Itga3 Col18a1 Bsg Comp Thbs1 Itga1 Itga10 Ibsp Itgae Itgad Cd47 Col13a1 F11r Spp1 Itgb1 Cd44 Itga4 Itgal Itgb7 Col4a1 Col4a2 Pecam1 Itgb2 Tnc Itgax Itga8 Itga9 Vtn Itga2 Icam1 Icam5 Itgb6 Icam4 Icam2 Itgav FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%10229570 Fibronectin matrix formation Ceacam1 Fn1 Itgb1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-RNO-6796648.1 TP53 Regulates Transcription of DNA Repair Genes Gtf2h5 Ercc2 Ccnh Ercc3 Ccnt2 Eloa Cdk7 Nelfa Nelfb Cdk9 Nelfe Ctdp1 Eloc Elob Supt4h1 Nelfcd Eloa2l Tcea1 Ssrp1 Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Polr2j Cdk13 Cdk12 Ell Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Ccnk Gtf2h3 CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence Hmga1 Rad50 Map2k3 Cdk4 H2ac18 Ezh2 Lmnb1 Erf Mapk10 Mapk11 Cebpb Suz12 Hist1h2bq Id1 Terf2 Ets1 Terf1 Ets2 Tinf2 Tp53 Acd Terf2ip Eed Cdk2 Pot1 H2aj H3-3b Hist3h2ba Txn Cdkn1b H2bc18 H2az2 Ube2d1 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Hist1h2ai Ehmt1 Map3k5 Tnik Cdkn2b Cdkn2d Mink1 Map4k4 Mapkapk5 Rb1 Mre11 Kat5 Nbn Mapk9 Mapk7 Kdm6b Mapk8 Mapk1 Rps27a Mapk3 Uba52 Ring1 Ube2s Fos Ccne1 Phc2 Ccne2 Cbx6 Atm Ube2c Cdc27 Phc1 Cdc26 Cbx4 Ccna1 Rps6ka3 Cdc23 Cbx2 Ccna2 Phc3 Anapc10 Cdk6 Anapc16 Rps6ka1 Anapc15 Anapc5 Anapc4 Anapc1 Bmi1 Rps6ka2 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 Rnf2 Map2k7 Map2k6 H2ab2 Ubb Mdm4 H2ac4 Ubc Ep400 H1-1 H1-0 Asf1a H1-5 Cabin1 Mapkapk3 H1-4 Mapk14 Hira Jun H4f3 Mapkapk2 Ubn1 Hmga2 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation Hspa8 Prmt3 Mettl22 Etfbkmt Kin Mettl21a Eef2kmt Eef1akmt2 Eef1akmt1 Camkmt Eef1a1 Eef2 Calm3 Etfb Rps2 CHAHP COMPLEX ASSEMBLY%REACTOME%R-RNO-9940465.1 ChAHP complex assembly Adnp Cbx1 Chd4 Cbx3 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 97%10230190 Deubiquitination Cdc25a Mat2b Babam1 Babam2 H2ac18 Psma4 Psma3 Brca1 Hif1a Psma6 Psma5 Uimc1 Psma2 Psma1 Stam2 Rnf123 Psmd12 Ide Psmd11 Psmd14 Psmd13 Atxn3 Siah2 Psmb5 Keap1 Foxo4 Psmb4 Psmb7 Psmb6 Psmb1 Apc Axin1 Psmb3 Psmb2 Psma7 Psmc5 Arrb1 Psmc2 Psmc1 Psmc4 Psmc3 Smad1 Psmd7 Smad4 Psmd6 Psmd8 Psmd2 Ube2d1 Smurf2 Smad2 Smad3 Usp9x Smad7 Psmd1 Adrm1 Kat2a Hist1h2ai Usp8 Traf3 Ripk1 Arrb2 Ufd1 Ar Cftr Otud3 Usp13 Tnks2 Axin2 Atxn7 Usp3 Mul1 Usp5 Rnf128 Rnf146 Tada2b Otub1 Wdr48 Tnks Usp44 Usp42 Usp48 Usp47 Ifih1 Usp34 Fkbp8 Usp33 Usp37 Usp22 Usp20 Usp26 Usp25 Usp24 Wdr20 Usp29 Usp28 Usp12 Usp11 Usp10 Usp16 Cdk1 Usp15 Usp19 Usp21 Snx3 Traf6 Usp2 Usp4 Ikbkg Cyld Otud7b Rps27a Map3k7 Traf2 Uba52 Tnip2 Josd2 Nod2 Josd1 Nod1 Ubb Mdm4 Ripk2 Taf9b Ubc Taf10 Gata3 Nfkbia Rad23b Nfrkb Foxk2 Foxk1 Uchl3 Uchl5 Kdm1b Usp14 Ino80e Ino80d Tfpt Rce1 Ino80c Usp18 ENSRNOG00000067432 Ino80b Tab1 Actr5 Esr1 Actr8 Ruvbl1 Senp8 Asxl1 Mbd5 Mbd6 Nlrp3 Uchl1 Asxl2 Ino80 Becn1 Actl6a Tp53 Ep300 Rhoa Kat2b Yy1 Tomm20 Vdac2 Vdac3 Vdac1 Suds3 Tomm70 Usp30 Usp7 Rig1 Tnip3 Tnip1 H2ac25 Zranb1 Yod1 Vcpip1 Otub2 Otud7a Skp2 Stam Tgfbr1 Stambpl1 Stambp Mysm1 Abraxas2 Actg1 Ccp110 Ddb2 Il33 Hcfc1 Rad23a Bard1 Prkn Tada3 Mcrs1 Clspn Ogt Birc2 Cdc20 Bap1 Ccna1 Nedd8 Ccna2 Polb Adrb2 Pten Myc Brcc3 H2ac4 Hgs ABRAXAS1 Vcp Psmb6l1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 97%10231066 Josephin domain DUBs Atxn3 Ubb Rad23b Ubc Uba52 Prkn Rps27a Josd2 Vcp Rad23a Josd1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229624 PECAM1 interactions Itgb3 Plcg1 Fyn Inpp5d Ptpn6 Itgav Pecam1 Ptpn11 Lyn Lck Yes1 Src CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 97%10229032 Creation of C4 and C2 activators Crp C1qa Colec10 C1s C1r ENSRNOG00000069193 AABR07065813.1 C1qc ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Fcn2 Fcn1 Mbl2 Masp1 Masp2 C1qb ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 97%10228152 Orc1 removal from chromatin Skp2 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Mcm7 Mcm8 Psmd12 Psmd11 Orc5 Orc4 Psmd14 Orc6 Psmd13 Orc1 Orc3 Orc2 Cdt1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc6 Psmb1 Psmb3 Cdk2 Psmb2 Mcm3 Mcm4 Mcm5 Psma7 Mcm2 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ccna1 Ccna2 Ubb Ubc Rbx1 Psmb6l1 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME DATABASE ID RELEASE 97%10230934 Assembly of the 9+0 primary cilium Dynll1 Dynll2 Kif3a Smo Kif3b Ppp2r1a Kif3c Ywhae Ywhag Kifap3 Pcnt Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Ift74 Dynlrb2 Ift56 Dynlrb1 Ift70a2 Dynlt5 Ift70b Dynlt2 Kif17 Ift20 Prkaca Ift43 Ift22 Ift81 Ift27 Cluap1 Nphp4 Cep97 Ift46 Csnk1d Dync2i1 Cep192 Dync2li1 Ift25 Dync2i2 Dynlt2b Rpgrip1l Ift80 Cep78 Traf3ip1 Cep76 Tmem67 Cep72 Fbf1 Cep70 Plk4 Cep89 Cep83 Cep57 Ift140 Tmem216 Unc119b C2cd3 Cep63 Mark4 Alms1 Septin2 Kif24 Ttbk2 Cep43 Mks1 Tctn3 Cep41 Ift52 Tctn1 Tctn2 Ninl B9d1 Ttc21b Atat1 Cc2d2a Tubb5 Arl3 Odf2 Ift57 Iqcb1 Haus7 Ahi1 Haus8 Nphp3 Haus4 Nphp1 Haus5 Rp2 Ift122 Haus6 Sstr3 Cpap Ofd1 Cep162 Haus1 Sclt1 Pafah1b1 Wdr35 Cngb1 Dync2h1 Nedd1 Ift172 Wdr19 Inpp5e Arl13b Pde6d Pcm1 Ssna1 Actr1a Tubg1 Akap9 Sfi1 Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Cep152 Rab11a Cep290 Cep164 Ccp110 Dync1h1 Plk1 Exoc3 Tnpo1 Exoc4 Exoc5 Mchr1 Exoc6 Cdk1 Exoc1 Dync1i2 Exoc2 Exoc7 Arf4 Exoc8 Thoc2l Rab3ip Cnga4 Pkd1 Cnga2 Asap1 Csnk1e Gbf1 Clasp1 Rab8a Ckap5 Hsp90aa1 Cct3 Rho Bbs2 Mapre1 Cct2 Bbs10 Mkks B9d2 Bbs12 Arl6 Ttc8 Tcp1 Lztfl1 Nde1 Bbip1 Bbs7 Cct8 Bbs5 Trip11 Bbs4 Cct5 Cct4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%10231752 Circadian clock Psmd8 Psmd2 Rps27a Per2 Per1 Psmd1 Per3 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 97%10228374 Formation of a pool of free 40S subunits Eif1ax Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Rpl4 Eif3e Rps14 Eif3h Rps15 Eif3g Rpl5 Eif3b Rps16 Eif3a Rpl3 Eif3d Rps17 Eif3c Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230486 Mitochondrial biogenesis Mt-atp6 Acss2 Idh2 Sirt3 Sod2 Gabpa Cycsl2 Atp5mc1 Atp5f1e Atp5f1d Atp5pb Atp5f1c Atp5pd Glud1 Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Sirt5 Cycs Mt-atp8 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%10231340 RUNX3 regulates WNT signaling Lef1 Runx3 Tcf7 Tcf7l2 Tcf7l1 Ctnnb1 FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles Fmo1 Fmo3 Fmo2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-RNO-2173789.1 TGF-beta receptor signaling activates SMADs Itgb3 Smad2 Smurf2 Smad3 Rps27a Smad7 Tgfb1 Tgfb2 Tgfb3 Bambi Ltbp3 Ltbp2 Ube2m Ltbp4 Ltbp1 Itgb8 Strap Uba52 Zfyve9 Tgfbr1 Tgfbr2 Furin Itgb1 Stub1 Nedd8 Mtmr4 Itga8 Fkbp1a Ubb Ubc Tgfbr3 Itgb6 Itgav Cbl Smad4 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-RNO-69601.1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Psmd8 Chek1 Psmd2 Chek2 Cdc25a Csnk1e Csnk1a1 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Mapk11 Psma1 Skp1 Uba52 Fbxw11 Psmd12 Psmd11 Psmd14 Psmd13 Plk3 Psmb5 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Gsk3b Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Mapk14 Psmd7 Psmd6 Psmb6l1 CA ACTIVATED K+ CHANNELS%REACTOME%R-RNO-1296052.1 Ca activated K+ channels Kcnn1 Kcnmb2 Kcnma1 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Kcnmb1 Kcnn2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%10231326 RUNX1 regulates transcription of genes involved in BCR signaling Pax5 Elf2 Cbfb Runx1 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs Hacd2 Hacd3 Hacd4 Tecr Acsbg1 Acsbg2 Hsd17b12 Acsl3 Acsl4 Acsl1 Elovl2 Hsd17b3 Elovl3 Acsl5 Elovl5 Acsl6 Elovl1 Acsf3 Elovl6 Elovl7 Tecrl Hacd1 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-RNO-8874211.1 CREB3 factors activate genes Creb3l3 Crebrf Mbtps1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange Rad50 Rad51b Chek1 Bard1 Top3a Rmi2 Rmi1 Rbbp8 Brip1 Brca2 Brca1 Mre11 Kat5 Xrcc2 Exo1 Nbn Atm Dna2 Wrn Rad51c Blm Rad51 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%10228742 RNA Polymerase II Transcription Elongation Gtf2h5 Ercc2 Ccnh Ercc3 Eloa Cdk7 Supt6h Nelfa Nelfb Cdk9 Nelfe Ctdp1 Ncbp2 Eloc Ncbp1 Elob Supt4h1 Nelfcd Mllt3 Skic8 Mllt1 Ssrp1 Ctr9 Paf1 Leo1 Ccnk Eaf1 Eaf2 Ccnt2 Eloa2l Tcea1 Cdc73 Polr2c Polr2a Aff4 Polr2b Polr2g Polr2h Polr2e Iws1 Polr2f Mnat1 Polr2i Polr2j Ell Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 97%10230476 PI and PC transport between ER and Golgi membranes Pitpnb SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins Smc5 Sp140 Rad52 Nsmce4a Nup58 Eid3 Nup37 Nsmce1 Nup205 Nsmce2 Pom121 Mageb10 Sp100 Nup107 Cetn2 Nup188 Tpr Nup160 Sumo2 Brca1 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Rpa1 Pias4 Ube2i Pias2 Xpc Blm Pias1 Sec13 Ring1 Xrcc4 Phc2 Phc1 Cbx4 Cbx2 Phc3 Bmi1 Pcgf2 Parp1 Rnf2 Pml Herc2 Tdg Rnf168 Stag2 Sumo1 Stag1 Smc1a Smc3 Sumo3 Nup93 Nup50 Nup35 Nup54 Smc6 Nup98 SEROTONIN RECEPTORS%REACTOME%R-RNO-390666.1 Serotonin receptors Htr6 Htr7 Htr5a Htr1d Htr1f Htr2a Htr4 Htr2c Htr1b Htr2b Htr1a SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%10229246 SHC1 events in EGFR signaling Hbegf Btc Egfr Ereg Egf Nras Grb2 Tgfa Kras Areg Sos1 Hras Shc1 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%10231196 Interleukin-36 pathway Il1f10 Il1rl2 Il36g Il36rn Il1rap Il36a TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 97%10229794 Tachykinin receptors bind tachykinins Tac3 Tac1 Tacr1 Tacr3 Tacr2 ACTIVATION OF PKB%REACTOME%R-RNO-165158.1 Activation of PKB Them4 Trib3 Pdpk1 Akt2 HYDROLYSIS OF LPE%REACTOME DATABASE ID RELEASE 97%10230458 Hydrolysis of LPE Pla2g4c SIGNALING BY TGFBR3%REACTOME%R-RNO-9839373.1 Signaling by TGFBR3 Acvr2a Fgf2 Inhba Mmp14 Mmp16 Timp1 Tgfb1 Psenen Tgfb2 Timp2 Psen1 Arrb1 Psen2 Inha Ncstn Aph1a Tgfbr3 Aph1b Gipc1 Arrb2 Tgfbr1 Tgfbr2 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 97%10230858 Oxidative demethylation of DNA Tdg BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 97%10231452 Biosynthesis of DPAn-3 SPMs Alox5 Alox15 Ptgs2 Alox12 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%10229118 G2 M DNA replication checkpoint Pkmyt1 Wee1 Cdk1 Ccnb2-ps2 Ccnb2 Ccna1 Ccna2 Ccnb1 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME%R-RNO-156580.1 Phase II - Conjugation of compounds Sult2a1 Glyat Sult2a6 Podxl2 Mat2a Mat2b Ugp2 Comt Mtr Gsta5 Gstz1 Gstm4 Mtrr Ugt1a1 Uxs1 Sult1c2 Bpnt2 Bpnt1 Glyatl3 Cyp1a2 As3mt Sult1b1 Ugt1a6 Gstk1 Ugt1a7 Slc35d1 Ugt1a8 Chac1 Chac2 Gstm7 Gstm5 Gstm1 Gstm2 Acsm2 Acsm4 Acsm5 Mat1a Sult1a1 AC114845.1 Ugt2b7 Akr1a1 Gsto1 Gsto2 Sult6b1 Ugt2a1 Ugt2a3 Ugt2b1 Ugdh Hpgds Gstp1 Gsta6 Gsta3 Ugt1a2 Gsta1 Ugt1a3 Gsta2 Ugt1a5 Ugt3a1 Ahcy Sult1e1 Gss Tpst1 Tpst2 Abhd14b Ggt1 Sult4a1 Ugt2b34l1 Ugt2b Ugt2b17 Gstt2 Ugt2b15 Gstt1 Ggct Gclc Esd Cndp2 Gclm Abhd10 Ggt5 Ggt7 Ggt6 Tpmt Nat1 Nat2 Nat3 Ugt2b37 Oplah Sult2b1 Mgst3 Mgst2 Mgst1 Sult2a2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-RNO-113510.1 E2F mediated regulation of DNA replication Ppp2cb Ppp2ca Ppp2r1b Ppp2r3b Prim2 Ppp2r1a Pola2 Rb1 Pola1 Prim1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%10229718 GRB2:SOS provides linkage to MAPK signaling for Integrins Itgb3 Rap1a Ptk2 Src Fn1 Grb2 Apbb1ip Fgb Fga Rap1b Sos1 Fgg Itga2b Tln1 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-RNO-1971475.1 Glycosaminoglycan-protein linkage region biosynthesis Sdc4 Sdc3 Dcn Gpc1 Gpc3 Gpc2 Gpc4 Gpc6 Fam20b Agrn Sdc1 Sdc2 Ncan Bcan Bgn Cspg5 Cspg4 Xylt1 Vcan Xylt2 Uxs1 B3galt6 Pxylp1 B4galt7 Gpc5 ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-RNO-9968297.1 Error-rone base excision repair (BER) hypermutates immunoglobulin genes Pold3 Rev1 Rps27a Rev3l Apex2 Poli Polh Ubb Ubc Uba52 Pold2 Mad2l2 Pcna G1 S TRANSITION%REACTOME%R-RNO-69206.1 G1 S Transition Cables1 Cdc25a Ccnh Skp2 Ccnd1 Ppp2r1b Ppp2r1a Cdk4 Rb1 Cdk7 Cul1 Akt3 Psma4 Psma3 Akt2 Psma6 Psma5 Akt1 Psma2 Psma1 Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Psmd12 Pole4 Dbf4 Psmd11 Orc5 Orc4 Psmd14 Orc6 Psmd13 Orc1 Orc3 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Rpa1 Rpa2 Psmb7 Cdc7 Psmb6 Cdc6 Psmb1 Prim2 Rpa3 Psmb3 Cdk2 Psmb2 Prim1 Mcm3 Mcm4 Mcm5 Mcm10 Psma7 Pole Mcm2 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ptk6 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Ppp2cb Ppp2ca Uba52 Ccne1 Ccne2 Ccna1 Ccna2 Cks1b Mnat1 Ubb Ubc Wee1 Ppp2r3b Psmb6l1 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 97%10231018 RAF MAP kinase cascade Spred1 Spred2 Cul3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Kl Fgf10 Flt3 Fgf3 Psmd12 Fgf22 Psmd11 Fgf7 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Kbtbd7 Psma7 Fgfr3 Psmc5 Arrb1 Egf Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Hgf Adrm1 Met Arrb2 Braf Ranbp9 Spta1 Ptpra Ncam1 Sptbn1 Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Brap Phb1 Sptbn4 Shoc2 Nras Grb2 Mras Fyn Kras Sos1 Hras Pdgfa Pdgfb Pde6d Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rasgrp1 Tln1 Pea15 Ptpn7 Paqr3 Erbb2 Ralgdsl1 Dusp16 Dusp10 Rasgrp4 Rasal1 ENSRNOG00000069024 Rasal2 Rasgrf1 Rasal3 Erbb3 Syngap1 Nrg2 Spred3 Rasa2 Dusp5 Nrg1 Rasa4 Nrg3 Rasa3 Dusp1 Nf1 Dab2ip Dusp9 Dusp8 Rapgef2 Rasgef1a Mapk1 Hbegf Rps27a Mapk3 Camk2a Ppp2cb Areg Ppp2ca Uba52 Frs2 Frs3 Vcl Ret Ppp2r5d Angpt1 Shc3 Dusp4 Ubb Ubc Dusp7 Tek Dusp6 Icmt Zdhhc9 Itgb3 Bcl2l1 Shc2 Abhd17b Arl2 Abhd17a Prkcq Ppp2r1b Ppp2r1a Golga7 Fnta Lypla1 Fntb Abhd17c Rce1 Mapk12 ENSRNOG00000067432 Egfr Mark3 Artn Gfra1 Gfra2 Map2k1 Gfra4 Ralgds Rap1a Kit Lamtor3 Src Lamtor2 Map3k11 Kitlg Map2k2 Ptpn3 Raf1 Jak2 Lat Pdgfrb Pdgfra Pspn Calm3 Gdnf Grin2d Nrtn Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Rasgrf2 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Lrrc7 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Ywhab Ereg Actn2 Prkg2 Csk Fgfr1 Btc Nefl Ppp1cb Rasa1 Grin1 Csf2rb Jak3 Dlg1 Dlg2 Dlg3 Grin2b Dlg4 Pik3r1 Pik3r2 Tgfa Camk2g Camk2d Camk2b Irs1 Irs2 Csf2 Shc1 Il2 Il3 Ppp5c Il5 Pik3cb Pik3ca Il17rd Wdr83 Il2ra Ksr1 Cnksr2 Il2rb Araf Ppp1cc Pebp1 Rbx1 Psmb6l1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-RNO-141333.1 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maoa Maob NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250941.1 Negative epigenetic regulation of rRNA expression H2bc6 H2bc4 Hist1h4m H2bc1 H2ac18 Suv39h1 Rrp8 H2aj Hist1h2ai H2ab2 H3-3b Hist3h2ba Sirt1 H2ac4 Mbd2 H2bc18 Hist1h2bq H2az2 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%10231680 Signaling by LTK Alkal2 Grb2 Alkal1 Ltk Pik3cb Sos1 Tnk2 Pik3ca Shc1 Pik3r1 Irs1 Pik3r2 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%R-RNO-977068.1 Termination of O-glycan biosynthesis St3gal4 St3gal2 Muc19 St3gal3 St6galnac3 Muc13 Muc15 St3gal1 Muc5b Muc4 Muc6 St6galnac2 St6gal1 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-RNO-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Bcl7c Actg1 Actl6a Bcl11a Bcl11b Phf10 Smarce1 Smarcc1 Smarca2 Ss18 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Smarca4 Dpf2 Arid1a Arid1b Bcl7a Bcl7b ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229960 Adenosine P1 receptors Adora1 Adora2b Adora3 Adora2a TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-RNO-168138.1 Toll Like Receptor 9 (TLR9) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Cd14 Chuk Mapk10 Mapk11 Tasl Irf5 Slc15a4 Pik3c3 Pik3r4 Tlr9 Rbsn Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Eea1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 97%10229928 EGFR Transactivation by Gastrin Nras Mmp3 Grb2 Kras Hbegf Sos1 Hras Prkca Egfr REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 97%10230782 Regulation of HSF1-mediated heat shock response Nup58 Nup37 Nup205 Hsph1 Pom121 Rps19bp1 Nup107 St13 Nup188 Tpr Nup160 Hspa5 Rae1 Ywhae Ndc1 Bag5 Bag3 Nup85 Sirt1 Bag2 Bag1 Nup42 Nup62 Nup43 Hspa9 Nup88 Aaas Hspa14 Hspa13 Nup214 Ranbp2 Hikeshi Nup155 Hsf1 Nup133 Nup210 Nup153 Rpa1 Rpa2 Hspa4 Dnajc2 Rpa3 Gsk3b Hspa12b Hspa12a Dnajb6 Dnajb1 Hspa8 Mapk1 Hspa2 Mapk3 Sec13 Hspa1b Hspa1a Hspa1l Nup93 Nup50 Nup35 Mapkapk2 Nup54 Nup98 G1 PHASE%REACTOME%R-RNO-69236.1 G1 Phase Ccnh Skp2 Ccnd1 Ppp2r1b Jak2 Ppp2r1a Cdk4 Rps27a Rb1 Cdk7 Rbl1 Abl1 Cul1 E2f4 E2f5 Cdkn1c Skp1 Rbl2 Ppp2cb Ppp2ca Uba52 Ccnd2 Ccne1 Ccne2 Ccnd3 Cks1b Cdk6 Cdk2 Lyn Src E2f1 Mnat1 Ubb E2f2 E2f3 Ubc Ppp2r3b Ppp2r2a Ptk6 Cdkn1b Tfdp2 Tfdp1 Cdkn2b Cdkn2d SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism Enoph1 Txn2 Mtrr Suox Mtap Slc25a10 Gadl1 Sqor Adi1 Cbs Mtr Ado Ahcy Bhmt Usf1 Fmo1 Bhmt2 Ethe1 Mpst Cth Mri1 Mat1a Cdo1 Tst LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-5632681.1 Ligand-receptor interactions Ihh Cdon Dhh Shh Ptch1 Hhip REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%10228766 Regulated Necrosis Chmp2b Sdcbp Hmgb1l2 Hmgb1l1 Gsdmd Cycsl2 Chmp3 Chmp7 Il18 Chmp6 Cdc37 Flot2 Flot1 Itch Cycs Peli1 Il1a Prkn Rps27a Ube2l3 Il1b Mlkl Gsdme Traf2 Pdcd6ip Birc2 Bax Ogt Ripk3 Fadd Uba52 Ripk1 Xiap Elane Gzmb Chmp4c Bak1 Stub1 Hsp90aa1 Hmgb1-ps34 Ubb Chmp4bl1 Ubc Casp8 Tradd Fas Cflar Casp3 Faslg Chmp2a Tnfsf10 Casp1 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%10230214 The NLRP3 inflammasome Pycard Txnip Sugt1 Txn Nlrp3 Mefv Hsp90ab1 Pstpip1 P2rx7 Panx1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%10228814 Muscle contraction Dmpk Atp1a2 Fxyd3 Fxyd4 Atp1a1 Atp1a4 Fxyd1 Fxyd2 Atp1a3 Fxyd7 Fxyd6 Ahcyl1 Pln Tnni3 Pak1 Atp1b1 Atp1b3 Atp1b2 Kcnip3 Kcnip4 Pxn Kcnip1 Kcnip2 Pak2 Atp2a1 Atp2b1 Atp2b4 Cacng8 Atp2a3 Atp2b3 Prkaca Cacng4 Atp2a2 Itga1 Itpr3 Itpr2 Slc8a1 Calm3 Mylk Slc8a2 Nppc Npr1 Nppa Npr2 Slc8a3 Corin Tpm4 Adam22 Abcc9 Kcnk12 Actn2 Kcnk15 Kcnk5 Cacna2d2 Pde5a Nos1 Kcnj11 Itpr1 Cacnb1 Vim Cacnb2 Akap9 Kcnd3 Kcnd2 Kcnd1 Kcnh2 Kcnq1 Kcna5 Tmod3 Kcnj2 Tln1 Kcnk13 Ryr2 Kcnk10 Kcnk16 Ryr1 Kcnk18 Fkbp1b Rlc-a Trdn Kcnk4 Trpc1 Kcnk2 Ces1d Kcnk1 Mme Kcnj4 Camk2g Kcnk9 Camk2d Camk2b Kcnk7 Kcnk6 Kcnj12 Kcnj14 Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Tmod1 Cacng6 Tmod4 Cacng7 Tmod2 Cacna1c Tcap Kcne5 Dmd Tpm2 Kcne4 Tpm1 Kcne3 Neb Kcne2 Tnni2 Clic2 Tnni1 Myl4 Camk2a Myh3 Asph Des Mybpc2 Myl1 Actn3 Myl2 Mybpc3 Myl3 Myh6 Vcl Stim1 Myl12b Myl7 Myl11 Myl9 Sorbs3 Myl10 Gucy1b1 Gucy1b2 Gucy1a1 Gucy1a2 Cald1 Lmod1 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-RNO-442660.1 SLC-mediated transport of neurotransmitters Slc6a20 Slc6a1 Slc6a4 Slc6a3 Slc6a19 Slc6a11 Slc6a15 Slc6a13 Slc6a14 Slc25a22 Slc22a2 Slc22a1 Slc6a5 Slc17a7 Slc6a9 Slc6a2 Slc17a8 Slc32a1 Slc17a6 Slc25a18 Slc6a7 INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling Il23r P4hb Il23a Tyk2 Jak2 Stat3 Il12rb1 Il12b CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%10230946 CD209 (DC-SIGN) signaling Raf1 Prkaca Prkacb Relb Lyn Ep300 Nfkb1 Nras Crebbp Fyn Kras Pak1 Hras Icam2 Rela Cd209a Pak2 Rps6ka5 Pak3 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 97%10228624 ERK1 ERK2 pathway Spred1 Spred2 Cul3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Kl Fgf10 Flt3 Fgf3 Psmd12 Fgf22 Psmd11 Fgf7 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Kbtbd7 Psma7 Fgfr3 Psmc5 Arrb1 Egf Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Hgf Adrm1 Met Arrb2 Braf Ranbp9 Spta1 Ptpra Ncam1 Sptbn1 Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Brap Phb1 Sptbn4 Shoc2 Nras Grb2 Mras Fyn Kras Sos1 Hras Pdgfa Pdgfb Pde6d Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rasgrp1 Tln1 Pea15 Ptpn7 Paqr3 Erbb2 Ralgdsl1 Dusp16 Dusp10 Rasgrp4 Rasal1 ENSRNOG00000069024 Rasal2 Rasgrf1 Rasal3 Erbb3 Cdk1 Syngap1 Nrg2 Spred3 Rasa2 Dusp5 Nrg1 Rasa4 Nrg3 Rasa3 Dusp1 Nf1 Dab2ip Dusp9 Dusp8 Rapgef2 Rasgef1a Mapk1 Hbegf Rps27a Mapk3 Camk2a Ppp2cb Areg Ppp2ca Uba52 Frs2 Frs3 Vcl Ret Ppp2r5d Angpt1 Shc3 Dusp4 Ubb Ubc Dusp7 Tek Dusp6 Icmt Zdhhc9 Itgb3 Bcl2l1 Shc2 Abhd17b Arl2 Abhd17a Prkcq Ppp2r1b Ppp2r1a Golga7 Fnta Lypla1 Fntb Abhd17c Rce1 Mapk12 ENSRNOG00000067432 Egfr Mark3 Artn Gfra1 Gfra2 Map2k1 Gfra4 Ralgds Rap1a Kit Lamtor3 Src Lamtor2 Map3k11 Kitlg Map2k2 Ptpn3 Raf1 Jak2 Lat Pdgfrb Pdgfra Pspn Calm3 Gdnf Grin2d Nrtn Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Rasgrf2 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Lrrc7 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Ywhab Ereg Actn2 Prkg2 Csk Fgfr1 Btc Nefl Ppp1cb Rasa1 Grin1 Csf2rb Jak3 Dlg1 Tyk2 Dlg2 Dlg3 Grin2b Dlg4 Pik3r1 Pik3r2 Il6st Tgfa Camk2g Camk2d Camk2b Irs1 Irs2 Csf2 Shc1 Il2 Il3 Il6 Ppp5c Il5 Pik3cb Il6r Pik3ca Il17rd Wdr83 Il2ra Ksr1 Cnksr2 Il2rb Araf Ppp1cc Pebp1 Rbx1 Ptpn11 Psmb6l1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-RNO-5654700.1 FRS-mediated FGFR2 signaling Fgf10 Frs2 Fgf3 Frs3 Fgf22 Fgf7 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Nras Grb2 Kras Sos1 Hras Ptpn11 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 Itgb3 Csnk2b Mapk1 Vav2 Ncam1 Mapk3 L1cam Egfr Nrp1 Itga9 Csnk2a2 Pak1 Csnk2a1 Fgfr1 Itga2b Itgav Map2k2 Rac1 Itgb1 Map2k1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229984 Bicarbonate transporters Ahcyl2 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc4a7 Slc4a9 Slc4a10 Slc4a1 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 97%10230236 Regulation of IFNA IFNB signaling Ifna4l1 Tyk2 Ifna1l1 Stat1 Ifnb1 Usp18 Ptpn1 Ifna4 Ifna1 Ptpn6 Ifnar1 Ptpn11 LOC120103158 LOC120103159 Ifnar2 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 97%10230664 Phosphate bond hydrolysis by NUDT proteins Nudt5 Nudt9 Nudt16 Nudt18 Adprm Nudt1 INTERLEUKIN-10 SIGNALING%REACTOME%R-RNO-6783783.1 Interleukin-10 signaling Il10rb Il10ra Tyk2 Il10 Stat3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%10229818 Transcriptional regulation of white adipocyte differentiation Pparg Hdac3 Rxra Ncor2 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cd22 Cd40 Cd34 Cd200r1l Madcam1 Pvr Cd40lg LOC120093164 Cd96 Crtam RT1-M6-2 Sell ENSRNOG00000069193 Vcam1 AABR07065813.1 Cd8b Cd8a ENSRNOG00000062915 Cd300le Igll1 Cd300ld ENSRNOG00000065191 Ighl12 B2m Cd300lg ENSRNOG00000062682 Cd300lf ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Klrb1a ENSRNOG00000066406 Klrk1 Clec4g ENSRNOG00000067897 ENSRNOG00000062685 Clec2e ENSRNOG00000070192 RT1-M10-ps5 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 Fcgr2 ENSRNOG00000063341 ENSRNOG00000065283 RT1-N3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Cd247 ENSRNOG00000067679 Cd3g ENSRNOG00000070832 Cd3e Cd3d ENSRNOG00000064085 ENSRNOG00000064041 Trav19 AC109737.1 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000065955 ENSRNOG00000064490 ENSRNOG00000066072 Trbv16 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 RT1-M1-5 ENSRNOG00000069940 Rt1-ec3 ENSRNOG00000067643 Itgb1 RT1-M5 RT1-M2 Cd81 C3 Cd19 Cxadr Siglec1 Siglec5 Siglec8 LOC100910497 Slamf6 AABR07044308.1 Slamf7 Hcst Kir3dl1 Pilrb2l4 Ifitm1 Ifitm2 Ifitm6 Pilrb1l3 Pilrb1l2 Jaml Pilrb-ps7 Cd160 Itga4 Itgal Itgb7 Pianp Itgb2 Siglec10 Trem2 Trem1 Cd226 Nectin2 Ifitm3-ps2 LOC134481331 Lair1 Icam1 Icam5 Icam4 Icam2 Treml2 Treml4 Cd200 Cd1d ifitm3 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%10229822 Regulation of IGF Activity by IGFBP Ngfg Pcsk9 Pappa2 Igfbp6 Igfals P4hb ENSRNOG00000066972 Igfbp2 Apoa2 Apoe Apoa5 Vcan Pnpla2 Ttgn1 Kng1 Fstl1 Chrdl1 Gpc3 Cp Serpina1 Mbtps1 Proc F2 Serpinc1 Serpind1 Fgf23 Prkcsh Tnc Apoa1 Alb Dmp1 Notum Bpifb2 Apol2 C4b Apol7bl1 LOC120093819 C3 Mmp2 Apol7al1 C4 Apol9a Mgat4a Gas6 Ahsg Spp2 Fn1 Ltbp1 Fga Fgg Sdc2 Ctsg Men1 Apob Chgb Pdia6 Ccn1 Amelx Qsox1 Lgals1 Scg2 Mxra8 Fam20a Fam20c Fuca2 Megf11 Stc2 Mia3 Wfs1 Bmp4 Hrc Serpina10 Fbn1 Ambn Tf Mepe Enam Bmp15 Igfbp7 Mfge8 Matn3 Rcn1 Vgf Hsp90b1 Vwa1 Prss23 Tmem132a Igf2 Afp Meltf Adam10 Ano8 Igfbp5 App Igfbp4 Golm1 ENSRNOG00000069479 Igfbp1 Amtn Nucb1 Sparcl1 Cst3 Gzmf Itih2 Dnajc3 Igf1 Penk Msln Plg Csf1 Spp1 Scg3 Ktn1 Il6 Ckap4 Timp1 Klk13 Cdh2 Aplp2 Mmp1b Igfbp3 ENSRNOG00000067174 Pappa Klk6 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-RNO-450520.1 HuR (ELAVL1) binds and stabilizes mRNA Elavl1 Set Tnfsf13 Anp32a Xpo1 Prkcd Nup214 Prkca SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10230010 Sodium-coupled phosphate cotransporters Slc20a2 Slc20a1 Slc34a1 Slc17a1 Slc34a2 Slc34a3 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 97%10231676 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Ccnc Tbl1x H2bc6 H2bc4 Hist1h4m H2bc1 Rb1 Med30 Abl1 Med31 H2ac18 Ppargc1a Ppargc1b Ajuba Hist1h2ai Crebbp Sirt1 Hdac3 Hist1h2bq Tbl1xr1 Ncoa2 Cdk5 Med23 Med24 Med20 Ncor2 Ep300 Med27 H2aj Gps2 Med12 H2ab2 Med1 H3-3b Med13 Hist3h2ba Ncoa3 Med14 H2ac4 Med10 Med4 Pparg Med6 Rxra H2bc18 Med16 Med17 H2az2 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement Crp C1qa C3 C2 C4 Colec10 C1s C1r ENSRNOG00000069193 AABR07065813.1 C1qc ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Fcn2 Fcn1 Mbl2 Masp1 Masp2 C4b C1qb FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%10231098 Fanconi Anemia Pathway Ercc1 Faap100 Ercc4 Rps27a Fancl Fancm Fanca Fancb Fancc Fance Fancf Fancg Slx1b Uba52 Atr Wdr48 Fanci Dclre1a Rpa1 Faap24 Dclre1b Rpa2 Faap20 Usp1 Mus81 Fancd2 Ube2t Rpa3 Haus3 Fan1 Eme2 Ubb Eme1 Ubc Atrip Slx4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250347.1 SHC1 events in ERBB4 signaling Ereg Nras Grb2 Kras Hbegf Sos1 Btc Nrg2 Hras Nrg1 Nrg3 Shc1 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Nup160 Rps27 Nup85 Dync1li2 Clip1 Nup43 Dync1li1 Xpo1 Ranbp2 Ppp2r5b Ppp2r5a Kif18a Nup133 Ppp2r5e Dync1h1 Plk1 Itgb3bp Dync1i2 Dync1i1 Nudc Sec13 Clasp1 Clasp2 Spc24 Ppp2cb Birc5 Ppp2ca Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Cenpa Spdl1 Pmf1 Ska2 Ska1 Ppp2r5d Ahctf1 Mapre1 Zwint B9d2 Pafah1b1 Ska2l1 Bub1 Zw10 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA Damage Checkpoint Psmd8 Chek1 Psmd2 Chek2 Cdc25a Csnk1e Csnk1a1 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Mapk11 Psma1 Skp1 Uba52 Fbxw11 Psmd12 Psmd11 Psmd14 Psmd13 Plk3 Psmb5 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Gsk3b Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Mapk14 Psmd7 Psmd6 Psmb6l1 GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation Ugt2b34l1 Ugt2b Ugt1a1 Ugt2b17 Uxs1 Ugt2b15 Ugt2a1 Ugp2 Ugt2a3 Ugt2b1 Ugdh Ugt1a6 Ugt1a7 Ugt1a2 Abhd10 Slc35d1 Ugt1a8 Ugt1a3 Ugt1a5 Ugt3a1 Ugt2b37 AC114845.1 Ugt2b7 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neuropilin interactions with VEGF and VEGFR Flt1 Nrp2 Kdr Nrp1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231428 Biosynthesis of E-series 18(R)-resolvins Alox5 Lta4h Alox15 Gpx4 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%10229240 Conjugation of phenylacetate with glutamine Acsm2 IRS ACTIVATION%REACTOME%R-RNO-74713.1 IRS activation Irs2 Ins1 Insr Ins2 Grb10 Irs1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling Cdc42 Fyn Dcc Rac1 Trio Ptk2 Nck1 Src MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%10230640 MASTL Facilitates Mitotic Progression Mastl Arpp19 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 97%10229988 Sodium Calcium exchangers Slc8a3 Calm3 Slc8a1 Slc24a4 Slc8a2 Slc24a3 Adam22 Slc24a2 Slc24a1 Slc24a5 Slc8b1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-RNO-9825892.1 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Lef1 Sin3a Tcf7 Tcf7l2 Tcf7l1 Hdac1 Ctnnb1 Hint1 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Akt2 Kl Igf1r Gab1 Flt3 Fgf10 Trib3 Fgf3 Fgf22 Fgf7 Pdpk1 Pik3c3 Them4 Pde3b Pik3r4 Gab2 Pik3r1 Pik3r2 Fgfr3 Igf2 Igf1 Irs1 Irs2 Frs2 Shc1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Pik3cb Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Pik3ca Klb Fgf19 Fgfr4 Tlr9 Grb2 Cilp Sos1 Fgfr1 Ptpn11 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%10228904 Cytosolic sulfonation of small molecules Sult2a1 Sult4a1 Sult2a6 Podxl2 Sult6b1 Sult1c2 Bpnt2 Bpnt1 Sult1b1 Sult1e1 Sult2b1 Tpst1 Tpst2 Sult1a1 Sult2a2 Abhd14b BETA DEFENSINS%REACTOME DATABASE ID RELEASE 97%10230444 Beta defensins Defb30 Tlr1 Tlr2 Defb14 Defb17 Defb41 Defb18 Defb42 Ccr6 Defb43 Defb21 Defb44 Defb5 Defb24 Defb1 Defb25 Defb28 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228622 RAF-independent MAPK1 3 activation Mapk1 Tyk2 Il6r Jak2 Mapk3 Pea15 Dusp4 Dusp16 Il6st Dusp10 ENSRNOG00000069024 Cdk1 Dusp7 Dusp6 Dusp5 Map2k2 Dusp1 Ptpn11 Dusp9 Dusp8 Map2k1 Il6 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME DATABASE ID RELEASE 97%10231540 NPAS4 regulates expression of target genes Bmal1 Maged1 Npas4 Arnt2 Arnt NEURONAL SYSTEM%REACTOME%R-RNO-112316.1 Neuronal System Gls Syt1 Slc6a11 Slc6a12 Ptprf Glul Hspa8 Chrnb4 Chrna3 Chrnd Chrnb2 Chrne Chrng Chrna4 Grm1 Grm5 Abcc9 Kcnj11 Sh3glb2 Slc18a3 Slc22a2 Slc22a1 Gls2 Gjc1 Myo6 Panx2 Panx1 Prkcb Camk2a Gjd2 Rps6ka3 Rps6ka1 Rps6ka2 Ap2s1 Gria1 Shank1 Shank3 Ptprs Homer1 Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Ppfibp2 Ppfibp1 Rab3a Rtn3 Flot2 Flot1 Epb41l2 Epb41l3 Slitrk5 Gng10-ps1 Epb41l5 Adcy3 Slitrk6 Adcy4 Slitrk3 Adcy1 Ap2m1 Slitrk4 Adcy2 Slitrk1 Camkk1 Slitrk2 Adcy7 Lrrtm1 Camkk2 Lrfn2 Adcy8 Lrrtm2 Lrfn3 Adcy5 Lrrtm3 Adcy6 Lrfn4 Adcy9 Lrrtm4 Lrfn1 Cacng8 Dlgap1 Aldh5a1 Lrrc4b Prkaca Cacng4 Homer3 Prkacb Cacng2 Prkcg Dlgap4 Cacng3 Dlgap3 Stxbp1 Dlgap2 Slc18a2 Gnai2 Nlgn2 Slc6a13 Gnai1 Nlgn1 Abat Prkca Il1rapl2 Unc13b Gnai3 Nlgn3 Grin2a Ntrk3 Gabrg2 Camk4 Arhgef9 Gabrg3 Prkar1a Slc5a7 Grin3a Prkar1b Calm3 Tspoap1 Grik5 Gng3 Grik2 Grik1 Gnal Grik4 Grik3 Gng5 Grin2d Gng4 Grin2c Pick1 Gabra4 Gng7 Gabra3 Gabra6 Gng8 Gngt1 Gabra5 Gabra2 Gnat3 Gabra1 Prkar2a Akap5 Slc6a1 Slc6a4 Slc6a3 Gnb2 Maoa Lrrc7 Gnb1 Glra3 Gnb4 Glra2 Gnb3 Glra1 Gnb5 Gng11 Syn3 Gng12 Syn2 Syn1 Actn2 Cacna2d3 Cacna2d2 Camk1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Slc17a7 Cacnb3 Cacnb4 Grip1 Slc32a1 Cacnb1 Cacnb2 Gabrr1 Gabrr3 Gad1 Gabrr2 Kcnh8 Kcnd3 Gad2 Apba1 Kcnh7 Kcnd2 Gabrq Gabrb1 Kcnh6 Kcnd1 Gabrb3 Gabrb2 Kcnh5 Nefl Kcnh4 Cacna1e Kcnh3 Cacna1a Kcnh2 Kcnq5 Cacna1b Kcnq1 Chrnb3 Kcna7 Comt Kcnmb1 Naaa Kcna6 Gja10 Grip2 Kcnmb2 Stx1a Rims1 Kcna5 Gria4 Kcna4 Gria3 Kcna3 Snap25 Kcnj3 Kcna10 Kcnj2 Kcna2 Gria2 Kcna1 Cask Kcnmb3 Epb41l1 Kcnmb4 Slc1a1 Kcnj1 Slc1a3 Chat Kcnn4 Slc1a2 Kcnn3 Lin7a Kcnk13 Abcc8 Il1rap Grin1 Slc38a2 Slc1a7 Kcnn2 Lin7b Kcnn1 Slc1a6 Kcnk10 Lin7c Kcnk16 Kcnv2 Slc38a1 Chrna2 Kcnk18 Kcnv1 Dlg1 Chrna1 Hcn3 Dlg2 Hcn4 Kcnma1 Dlg3 Kcnb2 Chrna7 Grin2b Gabbr1 Vamp2 Kcnb1 Dlg4 Chrna6 Kcnj8 Kcnf1 Chrna5 Chrna9 Kcnk4 Gabbr2 Dnajc5 Kcnk2 Cplx1 Kcnk1 Tomt Kcnab1 Kcns3 Rps6ka6 Tspan7 Kcnab2 Kcns2 Arl6ip5 Kcns1 Aldh2 Kcnj9 Kcnab3 Kcnc4 Kcnj6 Kcnc3 Kcnj5 Kcnc2 Kcnj4 Camk2g Kcnk9 Kcnc1 Camk2d Kcng4 Camk2b Glrb Kcnk7 Kcng3 Ncald Kcng2 Kcnj10 Kcnk6 Kcnj12 Kcng1 Htr3b Kcnh1 Htr3a Kcnj14 Kcnj15 Kcnj16 Hcn1 Hcn2 Il1rapl1 Ap2b1 Nsf Ap2a2 Ap2a1 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-RNO-3000171.1 Non-integrin membrane-ECM interactions Itgb3 Ddr1 Drp2 Sntg2 Sdc4 Utrn Sdc3 Tgfb1 Dmd Prkca Sgcz Snta1 Sntb2 Agrn Sntb1 Sgce Sgcd Itgb4 Sdc1 Sdc2 Sgcb Sgca Sgcg Itgb1 Fgf2 Megf11 Lama4 Itga6 Vtn Itga2 Itgav Dtna Dag1 Dtnb Sspn Ddr2 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 97%10230210 Interferon gamma signaling Ifngr2 Mapk1 Ifng Ifngr1 Raf1 Jak2 Mapk3 Prkcd Stat1 Socs1 Ptpn2 Socs3 Ybx1 Camk2a Sumo1 Ptpn6 Camk2g Camk2d Camk2b Pias1 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-RNO-9860276.1 SLC15A4:TASL-dependent IRF5 activation Chuk Ikbkg Tasl Irf5 Slc15a4 Ikbkb SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism Glb1l3 Glb1l2 Ctsa St3gal2 Hexa Hexb Arsa St3gal3 Smpd2 St6galnac5 Smpd3 Ugt8 St6galnac6 Smpd4 Smpd1 Gba1 Gba3 Gba2 Enpp7 B3galt4 Neu2 Sptlc1 Galc Mfsd2b Asah2 Fut2 Glb1 Sptlc2 Fut1 Neu3 Asah1 Sptlc3 Neu4 Ormdl2 Sptssa Sts Gm2a Degs2 Neu1 Ormdl3 Degs1 Arsl Cers6 Arsk Cers5 A4galt St8sia5 Arsj Cers4 Arsi Abcg2 Arsg Cers3 Gla Cers2 Sumf1 Fa2h Arsb Cyb5b Sumf2 Abcc1 Acer1 Sphk2 Acer2 St3gal5 Sgms1 Aldh3b1 Sgpl1 Spns2 Sphk1 Aldh3b2 Sgms2 Acer3 Plpp2 Kdsr M6pr Sgpp2 Plpp3 Plpp1 Sgpp1 B3galnt1 B4galnt1 Gal3st1 Cerk B3gnt5 Psap Glb1l Aldh3a2 Ugcg B4galt5 B4galt6 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230078 Hydroxycarboxylic acid-binding receptors Hcar2 Hcar1 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-RNO-9853506.1 Succinyl-CoA Biosynthesis Ogdh Dlst AC132020.1 Dld Kgd4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-RNO-1236975.1 Antigen processing-Cross presentation Psme2 Psme1 Psmb10 Psma4 Psma3 Psma6 RT1-M6-2 Psma5 Psma2 Psma1 B2m Cyba Cybb Psmd12 Cd207 Psmd11 Lnpep Psmd14 Vamp8 Psmd13 RT1-M10-ps5 Psmb5 Psmb4 Mrc2 Psmb7 Mrc1 Psmb6 Psmb1 Psmb3 Psmb2 RT1-N3 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Cd36 Psmc3 Snap23 Fcgr1a Psmd7 Psmb9 Psmd6 Psmb8 Psmd8 Psmd2 RT1-M1-5 Rt1-ec3 Psmd1 Adrm1 AABR07044308.1 Vamp3 Pdia3 RT1-M5 Ncf1 Ncf2 RT1-M2 Ncf4 Itgav Psmb6l1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 97%10228690 Ca-dependent events Adcy8 Adcy5 Adcy6 Mapk1 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Pde1b Pde1c Pde1a Pla2g4a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-RNO-2299718.1 Condensation of Prophase Chromosomes H2bc6 Ncapd3 H2bc4 Hist1h4m Ncapg2 H2bc1 Rb1 H2ac18 Hist1h2ai Kmt5a Set Mcph1 Hist1h2bq Smc4 Smc2 H2aj Ccnb1 H2ab2 Plk1 Hist3h2ba H2ac4 Cdk1 Ncaph2 Phf8 H2az2 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10231068 Complex I biogenesis Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Nubpl Rnf113a1 Acad9 Hspa9 Ndufv2 Ndufv1 Yjefn3 Ndufv3 Ndufab1 Ndufc2 Ndufa12 Ndufa11 Ndufa10 Ndufs1 Timmdc1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa5 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Mt-nd5 Mt-nd4 Ecsit Mt-nd6 Ndufb1 Hscb Mt-nd1 Ndufb3 Mt-nd3 Ndufb5 Mt-nd2 Ndufb8 Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes Actr1a Tubg1 Dynll1 Akap9 Nme7 Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Csnk1d Cep192 Tubgcp2 Clasp1 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Mzt1 Mzt2 Cep43 Cep41 Ninl Ckap5 Tubb5 Hsp90aa1 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Tubgcp3 Nde1 Cdk11b Nedd1 Pcm1 Ssna1 Tubg2 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-RNO-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane Ddost Ost4 Tmem258b Tusc3 Mib2 Pdcd1lg2 Cd274 B3gnt3 Stt3b Dad1 Pdcd1 Rpn2 Rpn1 Magt1 Ostc CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism Aldh7a1 Bhmt Slc44a1 Slc44a2 Dmgdh Chdh Slc22a4 Sardh NECTIN NECL TRANS HETERODIMERIZATION%REACTOME%R-RNO-420597.1 Nectin Necl trans heterodimerization Nectin2 Nectin1 Pvr Nectin4 Cadm3 Cadm1 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME%R-RNO-9860927.1 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Nfkbia Itgb3 Ikbkg Ppp2r1b Ppp2r1a Abl1 Stat1 Ikbke Ptpn1 Nfkb1 Gna11 Chuk Ppp2ca Rela Gnaq Itgb1 Vcl Pde4d Anxa2 Yap1 Capn2 Ptk2 Capns1 Ppp2r2a Itgav Ikbkb PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Clta Psmd12 Cltc Psmd11 Rac1 Psmd14 Psmd13 Dvl2 Dvl1 Dvl3 Psmb5 Wnt1 Psmb4 Fzd1 Psmb7 Fzd2 Psmb6 Fzd5 Psmb1 Psmb3 Psmb2 Fzd4 Rhoa Psma7 Psmc5 Psmc2 Prkcb Psmc1 Psmc4 Psmc3 Ap2m1 Wnt11 Psmd7 Psmd6 Pard6a Psmd8 Daam1 Psmd2 Ror1 Wnt5b Smurf2 Ror2 Smurf1 Pfn1 Cltb Rps27a Prkcg Wnt4 Fzd3 Psmd1 Ap2b1 Fzd7 Fzd6 Adrm1 Fzd8 Rac2 Prkca Rac3 Uba52 Prickle1 Arrb2 Wnt5a Ubb Ap2a2 Ap2a1 Ubc Ap2s1 Psmb6l1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-RNO-110313.1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Pold3 Rev1 Rps27a Rev3l Poli Polh Polk Ube2l6 Pole3 Pole2 Uba52 Pole4 Nploc4 Sprtn Ufd1 Trim25 Isg15 Pclaf Rpa1 Rpa2 Usp43 Pold1 Rpa3 Rchy1 Pold4 Pole Ubb Ubc Usp10 Rfc5 Uba7 Pold2 Vcp Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport Afg3l2 Mcub Pmpcb Spg7 Micu2 Pmpca Micu3 Micu1 Parl Slc8b1 Pheta2 Phb1 Maip1 Mcu Yme1l1 Stoml2 Phb2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking Nos3 Dnm2 Cav1 Nostrin NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Frs2 Braf Mknk1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf5 Fgf8 Fgf9 Src Fgfr3 Ubb Grb2 Ubc Cbl Ptpn11 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-RNO-69618.1 Mitotic Spindle Checkpoint Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Nup160 Nup85 Dync1li2 Nup43 Dync1li1 Xpo1 Ranbp2 Ppp2r5b Ppp2r5a Nup133 Ppp2r5e Itgb3bp Ube2d1 Pafah1b1 Zw10 Rps27 Clip1 Kif18a Dync1h1 Plk1 Dync1i2 Dync1i1 Nudc Sec13 Clasp1 Clasp2 Ppp2cb Spc24 Ppp2ca Birc5 Spc25 Ercc6l Ube2s Nuf2 Rangap1 Cdc20 Ube2c Cdca8 Cdc27 Incenp Cdc26 Knl1 Cdc23 Mad2l1 Ndel1 Anapc10 Sgo2 Anapc16 Sgo1 Anapc15 Bub1b Anapc5 Anapc4 Ckap5 Anapc1 Aurkb Anapc2 Cenpc Cenpa Anapc7 Spdl1 Pmf1 Ube2e1 Ska2 Cdc16 Ska1 Ahctf1 Ppp2r5d Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 97%10230162 Interleukin-3, Interleukin-5 and GM-CSF signaling Tec Jak2 Prkaca Rapgef1 Stat5a Stat5b Csf2 Inpp5d Shc1 Il2 Il3 Il5 Csf2rb Jak3 Pik3cb Pik3cd Syk Gab2 Pik3ca Vav1 Lyn Hck Yes1 Il2ra Pik3r1 Il2rb Pik3r2 Pik3r3 Grb2 Fyn Sos1 Crk Ywhaz Ptpn6 Cbl Inppl1 Ptpn11 Crkl SENSORY PERCEPTION%REACTOME DATABASE ID RELEASE 97%10228430 Sensory Perception Rdh11 Rdh10 Fnta Tas2r40 Fntb Tas2r41 Lpl Apoc2 Akr1c3l1 Apoc3 Apoa2 Apoe Apoa4 Akr1c1 Akr1c9 Akr1c12l1 Awat2 Lrp1 Sdc4 Sdc3 Lrp8 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Bco2 Itpr3 Gpc4 Bco1 Gpc6 Agrn Calm3 Clps Pnlip Rbp4 Lrp2 Apom Rbp2 Rbp1 Tas2r119 Lrat Opn1sw Tas2r39 Gngt1 Gnat3 Tas2r38 Rgs9bp Ppef1 Gnb1 Metap1 Gnb3 Metap2 Apoa1 Gnb5 Cnga1 Grk1 Grk4 Rgs9 Camkmt Cngb1 Gnat1 Gucy2e Gpc5 Rcvrn Nmt2 Sag Guca1b Guca1a Gucy2f Tas1r2 Tas2r120 Tas1r1 Tas1r3 Tas2r16 Tas2r13 Tas2r136 Tas2r140 Sdc1 Sdc2 Tas2r105 Tas2r107 Apob Tas2r4 Tas2r3 Tas2r7 Cyp4v2 Gpihbp1 Pde6g Akr1b10 Scnn1a Scnn1b Nmt1 Scnn1g Pde6a Pde6b Opn1mw Dhrs3 Rdh12 Akr1c18 Stra6 Akr1c19 Rpe65 Rbp3 Myo7a Akr1c21 Rlbp1 Rho Akr1c12 Akr1c13 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9937383.1 Mitochondrial ribosome-associated quality control Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Gadd45gip1 AC132020.1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Ndufab1 Mief1 Mrps9 Mrps2 Mrps7 Mrps5 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mrpl49 Mrps21 Kgd4 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%10228910 Dissolution of Fibrin Clot Anxa2 Hrg Serpinb6a S100a10 Serpinb2 Plg Plat Serpinf2 Plau Serpine1 Serpine2 Plaur REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10231640 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Ost4 Tmem258b Spcs3 Spcs1 Spcs2 Jup Csnk2a2 Dad1 Csnk2a1 Cdh1 Furin Pcsk6 Ctnnb1 Ddost Mogs Csnk2b Prkcsh Pomt1 Arhgap32 Pomt2 Pcsk7 Sec11c Canx Ganab Sec11a Pip5k1c Rpn2 Rpn1 Ostc TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Atad2 Lhb Cga Esr1 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 97%10230216 Regulation of IFNG signaling Ifngr2 Ifng Sumo1 Ifngr1 Jak2 Stat1 Socs1 Ptpn2 Socs3 Pias1 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%10230910 NIK-->noncanonical NF-kB signaling Psmd8 Psmd2 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Nfkb2 Psma6 Uba3 Chuk Psma5 Psma2 Ube2m Psma1 Skp1 Uba52 Fbxw11 Psmd12 Psmd11 Psmd14 Psmd13 Map3k14 Psmb5 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Relb Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230074 Rhesus glycoproteins mediate ammonium transport Rhcg Rhbg Rhag RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231576 RND1 GTPase cycle Cpd Vangl2 Muc13 Wdr6 Txnl1 Kif14 Rbmx Ccdc88a Ptpn13 Tmem59 Arhgap35 Stmn2 Dst Dsp Depdc1b Cav1 Fam83b Plxna1 Rras2 Frs2 Ubxn11 Frs3 Epha2 Kidins220 Grb7 Fam135a Arhgap5 Plekhg5 Stip1 Dlg5 Rnd1 Ankrd26 Pik3r1 Pik3r2 Flot2 Rasal2 Aldh3a2 Tfrc Epsti1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10229750 Cell junction organization Ost4 Tmem258b Cbll1 Pvr H2ac18 Eps15 Ezh2 Psma4 Psma3 Angptl4 Psma6 Jup Psma5 Psma2 Psma1 Csnk2a2 Dad1 Ctnnd1 Csnk2a1 Psmd12 Psmd11 Suz12 Pcsk6 Hist1h2bq Rac1 Ctnnb1 Psmd14 Psmd13 Hace1 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Vav2 Eed Psmb3 Psmb2 Itga6 Pomt1 H2aj Arhgap32 Prkci Pomt2 Src Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Sp1 Banp Pxn Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m Jak2 H2bc1 Rbbp7 Amot Arhgef6 Psmd1 Arhgef4 Adrm1 Hist1h2ai Pard6b Vasp Tesk1 Ilk Fermt2 Actn1 Fblim1 Parvb Flna Parva Itgb1 Flnc Mogs Cdh15 Nectin1 Cdh9 Cdh8 Nectin4 Cdh7 Cdh6 Cdh3 Prkcsh Cadm3 Cdh24 Cadm2 Cadm1 Mtbp Pcsk7 Afdn Ang2 Fyn Cdh18 Cdh17 Cdh13 Cdh12 Cdh10 Ganab Tiam1 Farp2 Rnf19b Plec Zeb2 Cdh11 Adam19 Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Cd151 Itgb4 Cdh1 Ctnna1 Cdc42 Tyk2 Megf11 Il6st Sec11c Canx Sec11a Pard6a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Stat3 Nfkb1 Birc2 Pard3 Dst Pard6g Uba52 F11r Xiap Rela Furin Vcl Il6 Il6r Ctsb Cdh2 H2ab2 Nectin2 Sdk1 Ubb Sdk2 Ctsl H2ac4 Ubc Ctss Smarca4 Pip5k1c Rpn2 Rpn1 Ostc Psmb6l1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231308 RUNX3 regulates CDKN1A transcription Runx3 Smad3 Tp53 Tgfb1 Smad4 LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors Cysltr2 Ltb4r Cysltr1 Gpr17 Ltb4r2 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%10229684 Intestinal lipid absorption Npc1l1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-RNO-69231.1 Cyclin D associated events in G1 Ccnh Skp2 Ccnd1 Ppp2r1b Jak2 Ppp2r1a Cdk4 Rps27a Rb1 Cdk7 Rbl1 Abl1 Cul1 E2f4 E2f5 Cdkn1c Skp1 Rbl2 Ppp2cb Ppp2ca Uba52 Ccnd2 Ccne1 Ccne2 Ccnd3 Cks1b Cdk6 Cdk2 Lyn Src E2f1 Mnat1 Ubb E2f2 E2f3 Ubc Ppp2r3b Ppp2r2a Ptk6 Cdkn1b Tfdp2 Tfdp1 Cdkn2b Cdkn2d PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1a2 Man1a1 Man1c1 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 97%10231632 mRNA Polyadenylation Snrpg Snrpb Snrpd1 Ncbp2 Ncbp1 Snrpd3 Snrpepl2 Ppp1ca Phf5a Smndc1 Hnrnpr-ps2 Prpf40a U2surp Cdc40 Pcbp2 Pcbp1 Sympk Clp1 Hnrnpr Dhx9 Hnrnpu Snrpa1 Rbm10 Ptbp1 Sugp1 Hnrnpc Hnrnpd Hnrnpf Hnrnpk Hnrnpl Pcf11 Cstf1 Nudt21 Cstf2 Dhx15 Cstf3 Srsf19 Srsf11 Srsf12 Tut1 Srrm2 Sf3a1 Sf3a2 Sf3a3 Ppp1cb Sf3b1 Sf3b3 Sf3b4 Sf3b5 Hnrnph2 Hnrnph1 Hnrnpa2b1 Srrt Snrnp70 Htatsf1 Papolg Ppp1r8 Fip1l1 Papola Snrpa Snrpc Snrpn Cherp Fus Cpsf4 Cpsf6 Cpsf7 Rbbp6 Rbm25l1 Cpsf1 Cpsf2 Rps27a Cpsf3 Prr3 Rbmx Ybx1 Dnajc8 Rbm25 Uba52 Srsf1 Rbm5 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Rbm17 Ddx46 Ddx42 Puf60 Polr2c Polr2a U2af1 Polr2b Polr2g Polr2h Hnrnpa1 Polr2e Polr2f Ubb Cstf2t Polr2i Ubc U2af1l4 Polr2j Tcerg1 Tra2b Pabpn1 Snrpf Gtf2f2 Gtf2f1 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 97%10230472 Synthesis of PI Cdipt Cds1 Pitpnm2 Pitpnm3 Pitpnm1 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 97%10231660 Mitochondrial protein degradation Suclg2 Mrpl12 Fech Cs Fh Afg3l2 Alas1 Aldh1b1 Spg7 Pmpca Pheta2 Uqcrq Oxsm Htra2 Lonp1 Aco2 Dbt Clpp Atp5f1c Iars2 Hspa9 Atp5pd Clpx Glud1 Shmt2 Atp5pf Ndufv1 Yjefn3 Hmgcs2 Ogdh Atp5mg Ndufv3 Atp5f1b Atp5f1a Atp5po Me2 Dld Ndufs1 Acadsb Ndufs3 Twnk Ech1 Aldh2 Ssbp1 Tfam App Arg2 Hspd1 Acot1 Mt-atp6 Acot2 Acot5 Acot3 Mrps2 Prkaca Pccb Ldhd Idh2 Cox5a Cox5b Nadk2 Mt-co1 Bdh1 Oxct1 Mdh2 Eci1 Uqcrc2 Star Idh3a Hsd17b10 Mrpl32 Acat1 Slc25a5 Aldh18a1 Mrps10 Pdk1 Pdhb Acad8 Hadh RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 97%10231318 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Ctsk Serpinb13 Ctsl REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation Chek2 Usp2 Ccng1 Ppp2r1b Ppp2r1a Rps27a Sgk1 Akt3 Daxx Akt2 Akt1 Mapkap1 Ppp2cb Ppp2ca Uba52 Usp7 Atm Pdpk1 Ccna1 Ccna2 Tp53 Cdk2 Phf20 Prr5 Ubb Mdm4 Rffl Ubc Mtor Cdk1 Rictor Mlst8 Rnf34 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%10231712 Modulation of host responses by IFN-stimulated genes Chuk Ube2l6 Fkbp5 Ifi44l Ikbkg Ifi44 Uba7 Rig1 Arih1 Trim25 Ikbkb Isg15 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229746 SDK interactions Sdk1 Sdk2 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME%R-RNO-9943962.1 CHD6, CHD7, CHD8, CHD9 subfamily H2bc6 H2bc4 Hist1h4m Fam124b H2bc1 Ctcf Chd8 H2ac18 H2aj Chd6 Hist1h2ai H2ab2 Chd7 H3-3b Hist3h2ba H2ac4 H2bc18 Hist1h2bq Ctnnb1 H2az2 Wdr5 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%10229088 Cytosolic sensors of pathogen-associated DNA Nkiras2 Tbk1 Nfkbia Ikbkg Sting1 Trim32 Rps27a Irf3 Nfkb2 Nfkb1 Chuk Crebbp Uba52 Stat6 Rela Ctnnb1 Dhx9 Irf7 Ddx41 Dhx36 Myd88 Ep300 Mre11 Ubb Nlrp4 Ubc Nfkbib Nkiras1 Aim2 Dtx4 Trim21 Ikbkb INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231198 Interleukin-18 signaling Il18bp Il18r1 Il18rap Il18 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%10228242 Glycogen metabolism Gbe1 Pgm1 Ugp2 Gys1 Ppp1r3c Phkg1 Calm3 Phkg2 Gaa Agl Pygl Pygm Phkb Akr1e2 Phka1 Phka2 Gyg1 PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation Eef2 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Prkag1 Prkag2 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Cd274 Os9 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Rnf5 Sel1l Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Prkab2 Prkab1 Uba52 Rnf185 Prkaa1 Derl3 Ubb Derl2 Ubc Erlin2 Erlin1 Vcp Prkag3 Psmb6l1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine Glyat Glyatl3 Acsm2 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 97%10228848 Interconversion of polyamines Sat1 Smox SHC-MEDIATED CASCADE:FGFR1%REACTOME%R-RNO-5654688.1 SHC-mediated cascade:FGFR1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Nras Grb2 Kras Kl Sos1 Fgfr1 Hras Fgf10 Fgf3 Fgf22 Shc1 Fgf17 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-RNO-168176.1 Toll Like Receptor 5 (TLR5) Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 TRNA PROCESSING%REACTOME%R-RNO-72306.1 tRNA processing Qng1 Yrdc DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%10228130 DNA Replication Pre-Initiation Kpnb1 Kpna6 Kpna1 H2ac18 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Psmd12 Pole4 Dbf4 Psmd11 Orc5 Orc4 Hist1h2bq Orc6 Psmd14 Orc1 Psmd13 Orc3 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Rpa1 Rpa2 Cdc7 Psmb7 Cdc6 Psmb6 Psmb1 Prim2 Rpa3 Cdk2 Psmb3 Psmb2 Prim1 Mcm3 Mcm4 H2aj Mcm5 Mcm10 Psma7 Pole Mcm2 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Psmd7 Psmd6 H2az2 Psmd8 Ube2d1 Psmd2 H2bc6 H2bc4 Hist1h4m H2bc1 Psmd1 Adrm1 Hist1h2ai Rps27a Uba52 Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 H2ab2 Ubb H2ac4 Ubc Psmb6l1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 97%10228578 Processing of Capped Intronless Pre-mRNA Slbp Snrpg Snrpb Cpsf4 Cpsf6 Cpsf7 Cpsf1 Cpsf2 Cpsf3 Lsm10 Lsm11 Zfp473 Ncbp2 Ncbp1 Sympk Clp1 Snrpd3 Snrpepl2 Cstf2t Fip1l1 Pcf11 Cstf1 Papola Pabpn1 Nudt21 Snrpf Cstf2 Cstf3 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%10228834 Regulation of clotting cascade F3 F7 Sdc4 Sdc3 Smpd1 Gpc1 Gpc3 Gpc2 F12 Gpc4 Gpc6 Agrn Klkb1 F2r Sdc1 Sdc2 Procr Proc F2 F8 Serpina5 Serpinc1 Serpine2 Serpind1 F10 Pf4 F11 Serpina10 Gp5 Tfpi Cd177 Gp9 Proz F9 Gp1bb Pros1 Prtn3 Gp1ba Gpc5 Serping1 Kng1 Serpine1 App Ano6 Ano5 Thbd RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%10228768 Release of apoptotic factors from the mitochondria Gsdmd Bax Cycsl2 Diablol1 Septin4 Bak1 Cycs Gsdme RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-RNO-388844.1 Receptor-type tyrosine-protein phosphatases Ptprf Il1rapl1 Lrrc4b Ptprs Il1rapl2 Ntrk3 Ppfibp2 Ppfibp1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Slitrk5 Slitrk6 Slitrk3 Slitrk4 Slitrk1 Slitrk2 Il1rap SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231364 SLIT2:ROBO1 increases RHOA activity Myo9b Rhoa DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230432 Downregulation of ERBB2:ERBB3 signaling Rnf41 Rps27a Akt3 Usp8 Akt2 Erbb2 Akt1 Ubb Ubc Erbb3 Uba52 Nrg2 Nrg1 GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation Gabrr3 Gabrr2 Gabrq Gabrb1 Gabrb3 Gabrb2 Kcnj3 Kcnj2 Gabbr1 Gabbr2 Kcnj9 Kcnj6 Kcnj5 Gng10-ps1 Kcnj4 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Kcnj10 Kcnj12 Adcy8 Adcy5 Kcnj15 Adcy6 Kcnj16 Adcy9 Gnai2 Gnai1 Gnai3 Gabrg2 Arhgef9 Gabrg3 Gng3 Gnal Gng5 Gng4 Gabra4 Gng7 Gabra3 Gabra6 Gng8 Gabra5 Gngt1 Gabra2 Gnat3 Gabra1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gabrr1 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-RNO-157858.1 Gap junction trafficking and regulation Gja1 Cltb Gja3 Gja5 Gja4 Gja10 Gja8 Dab2 Clta Gjd2 Cltc Tjp1 Gjd4 Dnm1 Gjd3 Dnm2 Gjc1 Gjc2 Myo6 Src Gjb2 Gjb1 Gjb4 Gjb3 Ap2m1 Gjb6 Gjb5 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 97%10228486 Transport of Mature Transcript to Cytoplasm Slbp Srsf11 Nup58 Srrm1 Nup37 Rbm8a Nup205 Pom121 Slu7 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Ncbp2 Nup42 Ncbp1 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Thoc2 Thoc3 Nup155 Thoc5 Nup133 Nup210 Thoc6 Nup153 Thoc7 Fip1l1 Eif4e Alyref Chtop Cpsf4 Rnps1 Cpsf1 Cpsf2 Gle1 Sec13 Cpsf3 Fyttd1 Casc3 Magohb Nxt1 Ddx39a Cdc40 Srsf1 Ddx39b Srsf9 Magoh Srsf7 Sympk Srsf5 Srsf3 Upf3b Srsf2 Sarnp Dhx38 Poldip3 U2af1 Nxf1 Eif4a3 Nxf5 U2af1l4 Nxf7 Nup93 Nup50 Nup35 Nup54 Nup98 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 97%10230422 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230192 GDP-fucose biosynthesis Fpgt Fcsk Gmds Gfus Fuom Slc35c1 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 97%10231592 Drug-mediated inhibition of MET activation Met Hgf NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling Spry2 Mapk1 Ppp2r1a Rps27a Mapk3 Ppp2cb Ppp2ca Uba52 Frs2 Braf Mknk1 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Src Ubb Grb2 Ubc Cbl Ptpn11 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 97%10228562 mitochondrial fatty acid beta-oxidation of saturated fatty acids Acadvl Acads Mecr Hadha Echs1 Acadm Hadhb Acadl Hadh SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-RNO-2559582.1 Senescence-Associated Secretory Phenotype (SASP) Cdk4 H2ac18 Cebpb Hist1h2bq Cdk2 H2aj H3-3b Hist3h2ba Cdkn1b H2bc18 H2az2 Mapk7 Ube2d1 H2bc6 Mapk1 H2bc4 Hist1h4m H2bc1 Rps27a Mapk3 Hist1h2ai Uba52 Ube2s Ube2c Cdc27 Ccna1 Cdc26 Rps6ka3 Ccna2 Cdc23 Ehmt1 Anapc10 Anapc16 Cdk6 Rps6ka1 Anapc15 Anapc5 Anapc4 Rps6ka2 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 H2ab2 Ubb H2ac4 Ubc Cdkn2b Cdkn2d GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization Rab1b Rab2a Mapk1 Golga2 Gorasp1 Blzf1 Rab1A Mapk3 Gorasp2 Plk1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%10230324 TRAF3-dependent IRF activation pathway Irf7 Irf3 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors Ptgfr Ptger4 Ptgdr2 Ptger2 Ptger3 Ptger1 Cysltr2 Ltb4r Cysltr1 Gpr17 Tbxa2r Ptgdrl Ptgir Ltb4r2 Ptgdr HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels Hcn1 Hcn2 Hcn3 Hcn4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) Ppp2r1a Ncbp2 Ncbp1 Ppp2r2a Pabpc1 Rnps1 Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Magoh Rpl39 Rpl8 Rps11 Upf3b Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Dcp1a Eif4a3 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 Rbm8a LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Upf3a Rps25 Gspt2 Rps26 Gspt1 Rps27 Rps28 Smg1 Rps29 Smg9 Smg8 Smg7 Rpl27a Smg6 Rpl31l15 Smg5 Rps20 Upf1 Upf2 Rps21 Etf1 Pnrc2 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Casc3 Magohb Rpl15 Rpl17 Rpl18 Rpl19 Ppp2ca Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a INTERLEUKIN-12 SIGNALING%REACTOME%R-RNO-9020591.1 Interleukin-12 signaling P4hb Vamp7 Tyk2 Jak2 Il12rb1 Il12b Il12rb2 Il12a ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 97%10229182 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Pttg1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ccnb1 Psma7 Plk1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Nek2l1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 REGULATION OF BACH1 ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231586 Regulation of BACH1 activity Bach1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%10228586 Processing of Intronless Pre-mRNAs Cpsf4 Cpsf6 Cpsf7 Cpsf1 Cpsf2 Cpsf3 Cstf2t Ncbp2 Fip1l1 Ncbp1 Pcf11 Cstf1 Papola Pabpn1 Sympk Nudt21 Clp1 Cstf2 Cstf3 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%10231692 Maturation of TCA enzymes and regulation of TCA cycle Sdhd Fxn Sdhc Sdhb Sdha Isca2 Isca1 Acat1 Nfs1 Idh2 Sirt3 Iscu Sdhaf1 Sdhaf2 Sdhaf3 Aco2 Lyrm4 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 97%10230864 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%10230224 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2hgdh Adhfe1 D2hgdh SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230820 SUMOylation of intracellular receptors Nr5a1 Pias3 Sumo2 Esr1 Hdac4 Ppara Nr3c2 Nr3c1 Vdr Rara Nr1h4 Ar Pias4 Ube2i Thrb Thra Pias2 Nr1h3 Sumo1 Nr1h2 Sumo3 Rxra Nr1i2 Nr5a2 Pgr Pias1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome Actr1a Tubg1 Dynll1 Akap9 Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Csnk1d Cep192 Clasp1 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Cep63 Alms1 Cep43 Cep41 Ninl Ckap5 Tubb5 Hsp90aa1 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Pafah1b1 Nde1 Nedd1 Pcm1 Ssna1 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-RNO-5620912.1 Anchoring of the basal body to the plasma membrane Actr1a Tubg1 Dynll1 Akap9 Sfi1 Ppp2r1a Dctn1 Cetn2 Dctn2 Cep250 Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Rab11a Cep290 Cep164 Ywhag Ccp110 Dync1h1 Plk1 Pcnt Cdk1 Dync1i2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Rab3ip Csnk1e Prkaca Nphp4 Cep97 Csnk1d Cep192 Clasp1 Rpgrip1l Cep78 Cep76 Tmem67 Cep72 Fbf1 Cep70 Rab8a Plk4 Cep89 Cep57 Cep83 Tmem216 C2cd3 Cep63 Mark4 Alms1 Septin2 Kif24 Ttbk2 Cep43 Tctn3 Cep41 Mks1 Tctn1 Tctn2 Ninl Ckap5 B9d1 Cc2d2a Tubb5 Hsp90aa1 Odf2 Haus7 Iqcb1 Haus8 Ahi1 Haus4 Haus5 Nphp1 Haus6 Ofd1 Cep162 Haus1 Mapre1 Cpap Sclt1 B9d2 Pafah1b1 Nde1 Nedd1 Pcm1 Ssna1 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%10231466 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 97%10230620 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Pard6a Smurf1 Rps27a Tgfb1 Prkcz Cgn Rhoa Ubb Pard3 Ubc Uba52 F11r Tgfbr1 Tgfbr2 PI-3K CASCADE:FGFR3%REACTOME%R-RNO-5654710.1 PI-3K cascade:FGFR3 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf5 Fgf8 Pik3ca Fgf9 Pik3r1 Fgfr3 Grb2 Gab1 Frs2 Ptpn11 Fgf16 Fgf17 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%10228966 Attachment of GPI anchor to uPAR Pigk Pigs Pigu Pigt Gpaa1 Pgap1 Plaur PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 97%10229194 Phosphorylation of Emi1 Fzr1 Cdk1 Fbxo5 Cdc20 Ccnb1 Plk1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events Rhoc Rhob Gna12 Kalrn Arhgef7 Itsn1 Adra1b Vav3 Adra1a Adra1d Btk Rock2 Vav2 Rock1 Vav1 Rhoa Ngef Mcf2l Tiam2 Plxnb1 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Sos2 Sos1 Tbxa2r Tiam1 NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance Tomt Slc22a2 Aldh2 Slc22a1 Slc6a4 Slc6a3 Maoa Comt CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Anapc16 Ube2d1 Anapc15 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Cdc14a Ube2e1 Cdc16 Ube2s Cdc20 Ube2c Cdc27 Cdc26 Cdc23 Anapc10 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10230964 RHO GTPase cycle Cul3 Sh3rf1 Stam2 Steap3 Als2 Fnbp1 Atp6ap1 Usp9x Sptbn1 Sptan1 Grb2 Sos1 Arl13b Vim Ndufs3 Ndufa5 Rbbp6 Stom Hsp90aa1 Ncf1 Ncf2 Ncf4 Hsp90ab1 Brk1 Baiap2 Nck1 Nckap1l Nckap1 Elmo2 Wasf3 Wasf2 Wasf1 Jup Abi2 Cyba Abi1 Cybb Cyfip2 Aaas Cyfip1 Lamtor1 Rhoa Ngef Zap70 Flot2 Flot1 Slitrk5 Slitrk3 Lck Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ddx39b Fermt2 Actn1 Ect2 Prex1 Trio Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Hnrnpc Pde5a Srrm1 Iqgap2 Iqgap3 Vav1 Pik3r1 Pik3r2 Pik3r3 Cpsf7 Rapgef1 Pik3ca Sos2 Tra2b Ptk2b Rhoc Rhob Lmnb1 Picalm Ocrl Cltc Tfrc Cpd Ckb Cftr Lman1 Gja1 Mtr Dbt Itsn1 Itsn2 Hmox2 Myo6 Emd Cdc37 Vrk2 Rasal2 Diaph1 Snap23 Pard6a Daam1 Vangl2 Golga3 Nudc Rnd2 Muc13 Wdr6 Txnl1 Rac2 Kif14 Scrib Rac3 Rbmx Ptpn13 Nisch Vamp3 Arhgap35 Dst Depdc1b Cav1 Fam83b Frs2 Ubxn11 Frs3 Kctd13 Epha2 Kidins220 Ktn1 Arhgap5 Grb7 Plxnd1 Prag1 Arhgap1 Dlg5 Ankrd26 Dsg1 Bltp3b Tnfaip1 Ckap4 Gps1 Cct2 Stx5 Ykt6 Trip10 Arfgap3 Rhog Arhgdib Garre1 Shmt2 Rac1 Arhgdig Lbr Diaph3 Vav3 Cdc42ep1 Pgrmc2 Dock5 Cops4 Dock3 Dock4 Dsg2 Arhgap21 Letm1 Mcam Vav2 Ophn1 Cops2 Stbd1 Pld1 Arhgdia Dock2 Vapb Arhgap32 Pak4 Esyt1 Plekhg3 Mpp7 Ankle2 Map3k11 Hspe1 Pak1 Spata13 Srgap1 Srgap2 Srgap3 Arhgap45 Gmip AABR07032856.1 Arhgap10 Arhgap17 Bcr Pak2 Dock6 Arhgap4 Fam13b Dock7 Dock8 Arap1 Arap3 Arap2 Arhgap22 Arhgap9 Arhgap20 Syde1 Arhgap26 Arhgap24 Cep97 Arhgap29 Osbpl11 Arhgap27 Pard6b Def6 Uaca Myo9b Arhgap6 Arhgap33 Arhgap31 Arhgap8 Arhgap30 Stmn2 Dnmbp Fam91a1 Prex2 Tagap Mtmr1 Dock10 Samm50 Dock11 Fam169a Plekhg1 Baiap2l2 Farp1 Vma22 Ralbp1 Gopc Stard8 Ralgapa1 Itgb1 Dlc1 Wwp2 Stard13 Fam135a Arhgap40 Wdr11 Arhgap44 Tuba1b Arhgap42 Msi2 Cdc42bpa Stip1 Cdc42ep4 Slk Syde2 Phip Pld2 Tpm4 Abl2 Akap12 Slc1a5 Jag1 Stk38 Scfd1 Nox3 Tex2 Nox1 Swap70 Amigo2 Stk10 Noxa1 Arhgap19 Arhgap15 Arhgap18 Arhgap12 Cit Rhobtb2 Rhobtb1 Fam13a Baiap2l1 Arhgap25 Arhgap28 Arhgap23 Pcdh7 Csk Fgd5 Rnf20 Pak6 Cct6a Pak5 Cdc42bpb Fmnl1 Slc4a7 Git2 Sowahc Aldh3a2 Noxo1 Taok3 Senp1 Chn2 Plekhg6 Tiam1 Twf1 Epsti1 Farp2 Cpne8 Sh3bp1 Pkn2 Nck2 AABR07021573.2 Pkn1 Nipsnap2 Git1 Faf2 Rhoh Abcd3 Rhof Acbd5 Anln Rhoj Actb Rhou Rhov Rhoq C1qbp Arhgef28 Arhgap11a Emc3 Cct7 Myo9a Ccdc88a Stam Tmem59 Kalrn Mtx1 Cavin1 Tmod3 Arhgef7 Cdc42ep2 Cdc42ep3 Plxna1 Rras2 Rtkn Nsfl1c Rhpn1 Rhpn2 Ccdc187 Basp1 Pak3 Ddrgk1 Actg1 Maco1 Cdc42 Ddx4 Peak1 Rnd3 Rnd1 Spen Rock2 Armcx3 Rock1 Add3 Ccp110 Rab7a Tor1aip1 Sema4f Fmnl2 Actc1 Fmnl3 Tmem87a Zfp512b Racgap1 Dsp Bcap31 Tjp2 Hgs Vcp ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%10229876 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2a Adra2c Adra2b SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf5 Fgf8 Fgf9 Fgfr3 Nras Grb2 Kras Sos1 Hras Shc1 Fgf16 Fgf17 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 97%10228850 PAOs oxidise polyamines to amines Smox POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification Copa Dynll1 Dynll2 Gorasp1 Epas1 Hif3a Ube2d2 Copb2 Hif1a Vhl Copb1 Cul2 Cope Eloc Stam2 Elob Ide Atxn3 Foxo4 Gosr1 Gosr2 Lman1l Sec24d Sec24c Sec24b Sec24a Smad2 Smad3 Usp9x Kat2a Hdac4 Nploc4 Rpl8 Ufd1 Nfe2l2 Prkcsh Alb Rps6 Bpifb2 Apol2 C4b Apol7bl1 LOC120093819 Apol7al1 C4 Apol9a Safb Zfp131 Ddx17 Mbd1 Casp8ap2 Uhrf2 Rpl27a Etf1 Rps23 Satb2 Atxn7 Usp3 Mul1 Usp5 Rnf128 Tada2b Otub1 Wdr48 Usp44 Usp42 Usp48 Usp47 Ifih1 Dcaf13 Fkbp8 Megf11 Usp33 Usp37 Usp22 Usp20 Usp26 Usp25 Usp24 Wdr20 Usp29 Usp28 Usp12 Usp11 Usp10 Usp16 Usp15 Usp19 Ano8 Ppara Rps2 Mgat5b Mitf Cdh2 Nop58 Tfap2c Nup93 Nup50 Thbs2 Nup35 Nup54 Nup98 Nup58 Nup37 Nup205 Pom121 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Ubxn7 Nup153 Galnt3 Tp53 Rraga Ggcx Bglap Sema5a Dph5 Dph6 Rnf181 Shprh Eef2 Rad18 Rnf152 Rnf40 Rnf144a Hltf Wac Tnip3 Tnip1 H2ac25 Zranb1 Yod1 Vcpip1 Otub2 Otud7a Prmt3 C3 Skp2 Arsa Neu2 Ltbp1 Neu3 Neu4 Tgfbr1 Sts Stambpl1 Stambp Neu1 Mysm1 Arsl Abraxas2 Arsk Chgb Arsj Arsi Pdia6 Ccn1 Arsg Amelx Lgals1 Sumf1 Scg2 Arsb Mxra8 Sumf2 Fam20a Fam20c Fuca2 Stc2 Wfs1 Bmp4 Hrc Fbn1 Ambn Mepe Ddb2 Enam Bmp15 Igfbp7 Mfge8 Matn3 Rcn1 Vgf Vwa1 Prss23 Tmem132a Afp Hcfc1 Igfbp5 Igfbp4 Golm1 Igfbp1 Amtn Nucb1 Sparcl1 Cst3 Itih2 Tada3 Penk Mcrs1 Ogt Ube2t Dtl Qtgal Adamts1 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Pofut3 Pofut4 Cdc25a Thsd4 Cfp Spon2 Npm1 Spon1 Sspo B3glct Muc19 B3gnt9 B3gnt8 B3gnt6 Muc15 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Apoa2 Galnt11 Apoe Galnt12 Gcnt7 Gcnt4 Gcnt3 Apoa5 Chst4 Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Skic8 Adamts15 Adamts16 Adamts17 Adamts18 Adamts19 Ctr9 Adamts10 Paf1 Sbspon A4gnt Adamts12 Muc5b Muc4 Muc6 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Kng1 Adamts20 Thsd7b Pex5 Gpc3 Pex10 Mbtps1 Cand1 Eef1a1 Chst10 Mgat5 Mgat2 Trim27 Mgat1 Otud3 Mgat3 Usp13 St6gal1 Manea Man1c1 Fut8 Smc6 Fuca1 Smc5 Man1a2 Sp140 Man1a1 St8sia6 Nsmce4a Man2a1 Hic1 Man2a2 Eid3 Nsmce1 Rab4b Mgat4c Nsmce2 Mgat4a Sp3 Mgat4b St8sia3 Mageb10 Sp100 Top2b Top2a Top1 Ttll6 Ttll7 Ttll4 Ttll5 Ttll10 Ttll2 Fn1 Ttll3 Adamts3 Ttll11 Fga Ttll12 Ttll8 Adamts2 Fgg Ttll13 Ttll9 Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Adamts14 Otulin Dhps Eif5a Fn3k Fn3krp Eif5a2 Dohh Slc35c1 Slc35a1 Cdk1 App Pias1 Traf6 Ikbkg Rps27a Map3k7 Psmg1 Dnajc3 Psmg4 Muc13 Ube2n Psmg3 Psmd10 Nfkb2 Pomp Psmd5 Psmd4 Traf2 Rab44 Rab2b Rab34 Skp1 Rab37 Rab20 Uba52 Ring1 Ptp4a2 Fbxw11 Rab23 Rab26 Phc2 Rab25 Rab29 Rab40b Rela Phc1 Rab15 Rab17 Cbx4 Ktn1 Rab19 Cbx2 Phc3 Rab3c Rab3b Rab3d Sin3a Mettl22 Etfbkmt Bmi1 Kin Mettl21a Btrc Eef2kmt Eef1akmt2 Eef1akmt1 Tnip2 Ckap4 Josd2 Nod2 Josd1 Nod1 Rnf2 F10 Pml F9 Pros1 Tdg Ubb Ripk2 Ubc Pcna Pcsk9 Nfkbia Ctsa Usp14 Cul1 Usp18 Pias3 Tab1 Sumo2 Ikbke Nub1 Ccdc22 Ccdc8 Spsb3 Ankrd9 Socs2 Commd10 Socs6 Dcun1d5 Dcun1d4 Rpa1 Dcun1d3 Dcun1d2 Dcun1d1 Cul9 Fem1b Fem1a Fem1c Ubd Pomt1 Neurl2 Commd8 B3galnt2 Pomt2 Commd9 Pomk Tulp4 Pomgnt2 Dcaf8 Dcaf4 Dcaf5 Dcaf6 Dcaf7 Dda1 Commd4 Commd5 Commd6 Commd7 Commd2 Commd3 Wdtc1 Cish Obsl1 Dcaf17 Usp30 Dcaf10 Dcaf11 Park7 Lipt1 Lipt2 Nfu1 Lias Calm3 Usp7 Fgf23 Camkmt Stag2 Stag1 Smc1a Smc3 Rig1 Pex2 Pex14 Pex13 Pex12 Fcgr3a Lypd6b Cd109 Rtn4rl2 Gpld1 Pigc Lypd8 Tecta Pigb Akp3 Lypd5 Lypd4 Sdc2 Alpp Lypd3 Negr1 Tex101 Lypd2 Piga Lypd1 Alpl Actg1 Pigk Pigm Alpi Pigl Pigg Alpg Pigf Pigh Opcml Psgb1 Tectb Dpm1 Dpm2 Dpm3 Pias4 Otoa Plaur Izumo1r Ube2i Ly6g6d Ceacam1 Cd52 Prss21 Nrn1 Ntm Ceacam6 Gp2 Xpnpep2 Meltf Gpihbp1 Cgm4 Thy1 Blm Art4 Art3 Atrnl1 Lsamp Reck Ube2v2 Sprn Plet1 Pigs Bard1 Pigu Pigt Prkn Prkdc Pign Ube2l3 Pigq Pigp Psca Spaca4 Cntn4 Pigw Clspn Msln Mdga1 Cntn3 Mdga2 Birc2 Folr2 Pigv Pigx Bst1 Vnn1 Cntn5 Xrcc4 Gpaa1 Psg29 Tpst1 Ly6e Tpst2 Ly6h Bap1 Pgap1 Satb1 Ccna1 Ccna2 Prnd Ly6d Tp53bp1 Prss41 Ddb1 Polb Cul4a Parp1 Cul4b Brcc3 Herc2 Rnf168 Sumo1 H2ac4 ABRAXAS1 Rbx1 Sumo3 Vcp Mvd Psmb6l1 Rad52 Lrr1 Psme2 Cops5 Psme1 Mat2b Babam1 Psmb10 Fbxl21 Babam2 Wsb1 H2ac18 Cul3 Ubxn1 Psma4 Ccnf Psma3 Brca1 Psma6 Mta1 Psma5 Uimc1 Psma2 Psma1 Cdc34 B3gnt3 Rnf123 Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Wdr5 Psmb5 Siah2 Psmb4 Keap1 Psmb7 Psmb6 Psmb1 Ube2g2 Apc Axin1 Psmb3 Calr Ube2g1 Psmb2 Kbtbd7 Kbtbd8 Psma7 Fbxw4 Psmc5 Fbxw5 Fbxw7 Psmc2 Gan Psmc1 Fbxw8 Psmc4 Fbxw9 Psmc3 Fbxw2 Klhl5 Smad1 Psmd7 Smad4 Psmb9 Psmd6 Ube2d3 Klhl3 Psmb8 Psmd8 Psmd2 Klhl2 Ube2d1 H2bc6 Spsb2 Rbbp5 Smurf2 Spsb1 H2bc4 Fstl1 Hist1h4m H2bc1 Spsb4 Rbbp7 Smad7 Psmd1 Chrdl1 Adrm1 Usp8 Hist1h2ai Kctd7 Kctd6 Ube2w Ube2m Ube2k Pdia3 Ube2b Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Cdc73 Spta1 St8sia4 Lrrc41 Klhl13 Klhl11 Ube2z Pcgf2 Sptbn1 Sptb Sptbn2 Fbxo21 Fbxo22 Sptan1 Sptbn5 Sptbn4 St8sia2 Fbxo27 Notum Uba6 Fbxw17 Klhl25 Ube2e3 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 F7 Fbxo31 Fbxo32 Gas6 Fbxl3 Fbxl4 Hdac2 Ctbp1 Fbxl5 Ahsg Fbxl7 Spp2 Hdac1 Zbtb16 Uba1 Cul5 Cul7 Fbxo41 Fbxo44 Klhl41 Qsox1 Fbxo40 Btbd1 Ndufab1 Fbxo2 Asb12 Serpina10 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Ube2r2 Fbxo4 Fbxo6 Fbxo7 Fbxo9 Fbxl15 Fbxl16 Snx3 Fbxl19 Thbs1 Asb9 Asb7 Asb6 Asb5 Asb4 Asb1 Etfb Scg3 Nrip1 Proz Aplp2 Mmrn1 Nr1h3 Taf9b Nr1h2 Rxra Taf10 Pgr Gata3 Esr1 Rara St8sia5 Pnpla2 Ep300 Rhoa Kat2b Yy1 Dlat Nr5a2 Cp B3gnt5 Hnrnpc Hnrnpk B3gnt7 B3gnt2 B4galt4 B4galt5 B4galt6 St3gal6 St3gal4 St3gal2 Srd5a3 St3gal3 B4gat1 St6galnac5 St6galnac6 St3gal1 B4galt2 B4galt3 Glb1 Vdr Men1 St3gal5 Nr1h4 Senp5 Senp5l1 Uba2 Fdx1 Rwdd2b Sae1 Il33 Senp2 Cmas Alg9 Alg8 Hsp90b1 Alg6 Alg5 Alg3 Canx Alg2 Alg1 Adam10 Gmds Gne Nus1 Pmm2 Pmm1 Nudt14 Umod Npl Dhrsx Asgr2 Adamts5 Asgr1 Slc17a5 Adamts4 Nanp Nans St8sia1 Mpi St6galnac3 Dhdds Dolpp1 Fuom Socs3 St6gal2 Dolk Alg13 Socs5 Alg14 Alg12 Mpdu1 Fpgt Gmppa B4galnt2 Csf1 Fcsk St6galnac1 St6galnac2 Dpagt1 Gfus Spp1 Furin Il6 Timp1 Myc Ing2 P4hb Arf1 Napa Vcan Golgb1 Rab5c Gcsh Arrb1 Ttgn1 Hspa8 Nr5a1 Traf3 Nr3c2 Nr3c1 Ripk1 Arrb2 F2 Proc Serpinc1 Serpind1 Ar Tnc Apoa1 Dmp1 Trim28 Thrb Thra Dlst Cftr Nr1i2 Lman1 Actr1a Lman2 Dctn1 Tfg L3mbtl2 Dctn2 Daxx Dctn4 Tnks2 Rab11b Axin2 Rab11a Dbt Rabggta Rabggtb Rnf146 Trappc2l Tnks Kdelr2 Kdelr3 Usp34 Trappc10 Dnmt1 Rab33b Rab33a Leo1 Kdelr1 Arf4 Arf3 Usp21 Chm Usp2 Usp4 Tmed10 Cyld Otud7b Rab27a Rab39a Rab27b Trappc6b Trappc6a Nagk Gnpnat1 Amdhd2 Sec31b Uap1 Gfpt1 Areg Gfpt2 Sec31a Pgm3 Renbp Ube2s F8 Ube2c Tbc1d20 Copz2 Copz1 Arf5 Golga2 Chml Ube2e1 Gps1 Uso1 Actr10 Stx5 Cop1 Ykt6 Mdm4 Fkrp Slc35a4 Igfbp3 Rxylt1 Crppa Arcn1 Dag1 Large1 Rab43 Large2 Pomgnt1 Fktn Amfr Icmt Engase Arfgap3 Ngly1 Rad23b Arfgap2 Nfrkb Arfgap1 Foxk2 Rab31 Foxk1 Uchl3 Uchl5 Rab35 Kdm1b Rab36 Ino80e Rab38 Ino80d Tfpt Rce1 Ino80c ENSRNOG00000067432 Ino80b Actr5 Actr8 Gria1 Ruvbl1 Rab1b Senp8 Asxl1 Mbd5 Mbd6 Nlrp3 Uchl1 Dync1li2 Asxl2 Ino80 Rab5a Dync1li1 Rab4a Becn1 Bet1l Actl6a Cops3 Cops4 Cops6 Cnih1 Cops2 Cnih3 Cnih2 Cops8 Rab3a Galnt1 Galnt2 Tomm20 Vdac2 Vdac3 Col7a1 Vdac1 Suds3 Trappc9 Tomm70 Ppp6c Sar1b Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Csnk1d Serpina1 Mrtfa Rab21 Rab1A Mcfd2 Rab10 Rab13 Rab12 Rab14 Rab18 Folr1 Rab2a Bet1 Ins1 Scfd1 Ins2 Cog1 Cog2 Cog3 Rnf20 Cog4 Preb Cog5 Cog6 Cog7 Senp1 Cog8 Ank1 Cetn2 Tmem115 Stam Sec23ip Sec16b Sec16a Cops7a Apob Cops7b Ctsc Ppp6r3 Mia2 Mia3 Ccp110 Rab7a Dync1h1 Rab7b Tf Tmed9 Ctsz Pias2 Tgfa Dync1i2 Riox2 Xpc Rab6b Rab6a Rad23a Rab5b Dync1i1 Stx17 Jmjd6 Rab9a Rab9b Sec13 Bcl10 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Rab8b Birc5 Rab8a Tmed7 Rangap1 Cdc20 Cdca8 Ankrd28 Incenp Cd59 Nedd8 Cd55 Aurkb Sec22a Adrb2 Nsf Napb Pten Napg Sec23a Hgs Lman2l PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi Notch3 Tmed2 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors Hic1 Sp3 Mitf Pias3 Sumo2 Pias4 Mta1 Ube2i Tfap2c Pias2 Sumo1 Sumo3 Tp53bp1 Pias1 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%10231400 Threonine catabolism Sdsl Rida Sds INOSITOL TRANSPORTERS%REACTOME%R-RNO-429593.1 Inositol transporters Slc2a13 Slc5a11 Slc5a3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%10229074 Cytokine Signaling in Immune system Nedd4 Cd40 Cd40lg Ube2d2 Psma4 Psma3 Psma6 Psma5 Ube2l6 Psma2 Psma1 Eloc Elob Flt3 Psmd12 Psmd11 Grb10 Psmd14 Psmd13 Ppp2r5a Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Psmd7 Psmd6 Ube2d3 Psmd8 Psmd2 Ube2d1 Psmd1 Adrm1 Ptpn2 Ptpn1 Ube2m Nras Grb2 Fyn Kras Sos1 Hras Uba7 Mapt Uba3 Cul5 Tnfsf4 Tnfsf13b Eda Tnfrsf17 Tnfrsf25 Tnfrsf4 Tnfsf11 Tnfsf8 Tnfrsf8 Edaradd Tnfsf9 Edar Tnfrsf1b Tnfsf15 Tnfsf13 Tnfrsf9 Tnfrsf1a Tnfrsf11b Tnfsf18 Lta Eda2r Tnfrsf18 Sh2b1 Gh1 Relb Nck1 Foxo3 Fkbp5 Tp53 Sphk1 Lyn Yes1 Cd4 Lck Ifngr2 Ifng Ifngr1 Raf1 Jak2 Dhx9 Sfn Il12b Il12a Il36a Crkl Stxbp2 Tbk1 Il23r Cntf Il20rb Il23a Il20ra Cntfr Il1rn Tslp Ebi3 Il31ra Il12rb1 Il12rb2 Tollip Lif Il1f10 Stx1a Gsdmd Stat5a Snap25 Stat5b Il36g Sdc1 Il10 Il11 Ctsg Stat6 Il15 Il13 Il1rap Il18 Il16 Il22ra2 Osmr Csf2rb Ifnlr1 Jak3 Vamp7 Tyk2 Syk Gab2 Vamp2 Vav1 Hck Il18r1 Pik3r1 Pik3r2 Pik3r3 Il33 Il6st Il34 Il10rb Hsp90b1 Il10ra Canx Stx4 Stx3 Inppl1 Il21 Il22 Il18bp Il11ra1 Il20 Il24 Clcf1 Osm Il27 Crlf1 Il1rapl1 Il1a Il22ra1 Rapgef1 Il1b Stat3 Stat1 Ctf1 Socs1 Socs3 Irs1 Irs2 Socs5 Lifr Sqstm1 Ybx1 Txlna Map3k3 Il36rn Csf1 Csf2 Inpp5d Brwd1 Shc1 Furin Il2 Il4 Ghr Prl Il3 Prlr Il6 Csf3 Csf1r Il5 Il7 Il9 Irak4 Irak3 Pik3cb Il6r Pik3cd Il4r Pik3ca Myd88 Ptprz1 Il18rap Il2ra Il2rb Il15ra Il13ra2 Il1rl2 Il1rl1 Smarca4 Sos2 Il7r Crk Ywhaz Ptpn6 Cbl Ptpn11 Ifnl1 Casp3 Ptk2b Prkra Casp1 Ifnl3 Tec Il1r2 P4hb Il1r1 Npm1 Tarbp2 Il9r Irf3 Hspa8 Traf3 Tnfsf14 Tnfsf12 Tnfrsf11a Tnfrsf13c Tnfrsf12a Ltb Ltbr Akt3 Akt2 Akt1 Cdk1 Nkiras1 App Mapk9 Atf2 Ikbkb Tnf Pim1 Atf1 Pias1 Gbp5 Mapk7 Ilf2 Nkiras2 Ilf3 Mapk8 Traf6 Ifna4l1 Snca Mapk1 Peli1 Mavs Ikbkg Faap100 Map3k8 Ifna1l1 Ifi44 Rps27a Map3k7 Hspa2 Mapk3 Dnajc3 Fancl Ube2n Ifnb1 Fancm Lrrc14 Nfkb2 Fanca Nfkb1 Fancb Traf2 Fancc Fance Fancf Camk2a Skp1 Fancg Ppp2cb Dus2 Ppp2ca Ifna4 Uba52 Ifna1 Fbxw11 Irf9 Fos Hspa1b Vrk3 Hspa1a Pggt1b Alpk1 Rela Ifnar1 LOC120103158 LOC120103159 Rps6ka3 Hspa1l Rps6ka5 Ifnar2 Peli2 Gbp2 Rps6ka1 Gbp1 Tifa Gbp3 Peli3 Faap24 Faap20 Rps6ka2 Ifi44l Btrc Ube2e1 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Kpnb1 Ppp2r1b Ppp2r1a Kpna1 Fnta Usp14 Cul1 Fntb Tab3 Tab2 Adar Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Ppm1b Mx2 Eif2ak2 Arih1 Trim25 Becn1 Isg15 Flnb Plcg1 Prkaca Prkcd Pde12 Rig1 Rnasel Oasl Actb Actg1 Camk2g Camk2d Camk2b Birc2 Map3k14 Sumo1 Rbx1 Psmb6l1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%10229702 Platelet degranulation Itgb3 Vegfa Vegfd Vegfc Vegfb Aldoa Cyb5r1 Egf Cd36 Kng1 Tuba4a Hgf Serpina1 Calm3 F13a1 Actn1 Flna Abcc4 Phactr2 Apoa1 Alb Vti1b Chid1 Actn2 Cfd Pcdh7 A1bg Serping1 Psap Pdgfa Clu Serpine1 Ppbp Pdgfb Islr Pcyox1l Stxbp2 AABR07021573.2 Hrg Sparc Lhfpl2 Gas6 Sytl4 Ly6g6f Tgfb1 Ahsg Tgfb2 Spp2 Tgfb3 Cd109 Serpina3n Timp3 Fn1 Fam3c Fgb Fga Serpinf2 Fgg Itga2b Tln1 Anxa5 Actg1 Qsox1 Brpf3 Lgals3bp Lamp2 Tf Wdr1 Maged2 Endod1 Serpina4 Habp4 Cdc37l1 Igf2 Tagln2 App Itih4 Itih3 Nhlrc2 Fermt3 Lefty2 Thbs1 Manf Lefty1 Apoh Igf1 Gtpbp2 Orm1 Rab27b Ecm1 Ola1 Ctsw Actn4 Tmsb4x Plg Cd63 Tor4a F8 Tmx3 Scg3 Vcl Selp Cyrib Sccpdh Srgn Pecam1 Timp1 Pf4 Aplp2 Mmrn1 Pros1 Cd9 Plek Sod1 A2m PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 97%10229904 Prostacyclin signalling through prostacyclin receptor Ptgir CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 97%10230588 Calcineurin activates NFAT Nfatc1 Ppp3r1 Fkbp1a Calm3 Ppp3ca Nfatc3 Nfatc2 Ppp3cb NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) Rad50 H2bc6 Ube2v2 H2bc4 Bard1 Hist1h4m Babam1 H2bc1 Prkdc Babam2 Ube2n Nhej1 Brca1 Xrcc6 Uimc1 Poll Tdp2 Xrcc5 Tdp1 Xrcc4 Atm Hist1h2bq Tp53bp1 Rif1 Paxip1 Pias4 Mre11 Brcc3 Herc2 Hist3h2ba Kat5 Rnf168 ABRAXAS1 Nbn Polm Rnf8 Dclre1c Lig4 Nsd2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%10228528 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Pold3 Rad50 Rad52 Ercc1 Ercc4 Babam1 Babam2 Topbp1 Rbbp8 Brca2 Brca1 Rad51ap1 Polh Polk Uimc1 Pole3 Rad1 Pole2 Pole4 Hist1h2bq Rpa1 Rpa2 Rpa3 Cdk2 Pole Hist3h2ba H2bc6 H2bc4 Hist1h4m H2bc1 Ppp4r2 Pias4 Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Dna2 Sirt6 Rad51c Blm Rad51b Chek1 Ube2v2 Rad9a Rad9b Bard1 Top3a Rps27a Abl1 Palb2 Ube2n Firrm Ppp4c Clspn Rad17 Xrcc3 Slx1b Xrcc2 Uba52 Atm Atr Ccna1 Ccna2 Tp53bp1 Lig1 Mus81 Pold1 Rmi2 Fignl1 Rmi1 Pold4 Brip1 Brcc3 Herc2 Ubb Rnf168 Ubc Exo1 ABRAXAS1 Sumo3 Rfc5 Rnf8 Pold2 Rfc3 Rhno1 Slx4 Rfc4 Wrn Pcna Nsd2 Rfc1 Spidr Rfc2 Rad51 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229218 Telomere C-strand (Lagging Strand) Synthesis Pold3 Pola2 Pola1 Chtf8 Terf2 Terf1 Tinf2 Rpa1 Fen1 Chtf18 Rpa2 Ctc1 Lig1 Stn1 Acd Prim2 Pold1 Terf2ip Rpa3 Ten1 Dscc1 Prim1 Pot1 Pold4 Rfc5 Pold2 Rfc3 Dna2 Wrn Rfc4 Pcna Blm Rfc1 Rfc2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-RNO-1299503.1 TWIK related potassium channel (TREK) Kcnk10 Kcnk4 Kcnk2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-73930.1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Polb Apex1 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%10229506 TNFR2 non-canonical NF-kB pathway Cd40 Cd40lg Cul1 Psma4 Psma3 Psma6 Uba3 Chuk Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Tnfsf4 Psmb7 Tnfsf13b Psmb6 Eda Psmb1 Tnfrsf17 Psmb3 Tnfrsf25 Tnfrsf4 Psmb2 Tnfsf11 Tnfsf8 Tnfrsf8 Edaradd Tnfsf9 Psma7 Edar Tnfrsf1b Psmc5 Tnfsf15 Psmc2 Tnfsf13 Tnfrsf9 Psmc1 Tnfrsf1a Psmc4 Tnfrsf11b Psmc3 Tnfsf18 Lta Eda2r Tnfrsf18 Psmd7 Tnf Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Nfkb2 Traf2 Traf3 Ube2m Birc2 Skp1 Uba52 Fbxw11 Map3k14 Btrc Relb Ubb Tnfsf14 Tnfsf12 Ubc Tnfrsf11a Tnfrsf13c Tnfrsf12a Ltb Ltbr Psmb6l1 SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Nras Grb2 Kras Sos1 Hras Shc1 Fgf16 Fgf17 CO-INHIBITION BY CTLA4%REACTOME%R-RNO-389513.1 Co-inhibition by CTLA4 Ppp2r1b Ppp2r1a Ppp2r5e Cd86 Cd80 Ppp2r5d Lyn Akt3 Yes1 Src Akt2 Akt1 Fyn Ppp2cb Ppp2ca Ctla4 Ptpn11 Lck Ppp2r5b Ppp2r5a HEDGEHOG 'ON' STATE%REACTOME DATABASE ID RELEASE 97%10230084 Hedgehog 'on' state Smo Csnk1a1 Cul3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Itch Psmd7 Psmd6 Psmd8 Psmd2 Smurf2 Smurf1 Rps27a Psmd1 Adrm1 Gpr161 Ihh Ulk3 Uba52 Cdon Grk2 Dhh Ptch1 Hhip Cdc73 Dzip1 Gli1 Gli3 Gli2 Shh Numb Kif7 Evc Spopl Ubb Ubc Evc2 Rbx1 Spop Sufu Psmb6l1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%10228500 SLC-mediated transmembrane transport Slc44a1 Slc44a2 Slc6a11 Slc6a12 Slc22a4 Slc5a5 Slc12a1 Slc12a4 Slc29a3 Slc12a5 Slc28a3 Slc12a2 Slc28a2 Slc12a3 Slc29a1 Slc12a6 Slc12a7 Slc34a1 Slc5a6 Slc5a8 Slc34a2 Slc2a9 Slc2a12 Slc45a3 Slc2a10 Slc6a7 Slc5a10 Slc50a1 Mfsd4b4 Fgf21 Slc2a1 Slc2a4 Slc2a3 Slc5a2 Slc25a10 Slc2a7 Slc5a4 Slc15a1 Ctns Slc15a3 Slc7a5 Slco1a4 Slc27a1 Lcn12 Lcn9 Arl2bp Vegp2 Vegp1 Slc33a1 Slc27a4 Slc25a5 Apod Slc28a1 Slc27a6 Slc29a4 Slc13a5 Emb Slc16a7 Slc13a3 Slc13a2 Slc4a1 Slc22a2 Slc22a1 Slc22a3 Slc35d2 Slc3a2 Slc35c1 Slc36a4 Slc35d1 Slc25a22 Slc35b4 Slc35a3 Slc35a2 Slc35b3 Slc35a1 Slc35b2 Runx1 Slc26a2 Slc26a1 Slc25a18 Slc26a6 Slc25a11 Slc26a4 Slc26a3 Slc29a2 Slc26a9 Slc26a11 Slc26a7 Slco3a1 Slco4a1 Slco2a1 Slco4c1 Slco1c1 SLC16A2 Slc10a6 Slc6a5 Slc6a9 Slc6a2 Slc17a8 Slc17a6 Slc20a2 Slc20a1 Ahcyl2 Slc17a1 Arl2 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc4a9 Slc13a4 Slc13a1 Slc34a3 Slc4a10 Slc15a4 Slc7a11 Slc7a10 Slc16a3 Slc16a8 Slc7a6 Slc7a7 Slc16a1 Slc7a8 Slc2a8 Slc7a9 Slc2a13 Slc5a11 Slc5a3 Slc67a1 Slc25a26 Slc14a2 Slc30a10 Slc14a1 Slc47a1 Slc24a4 Slc41a2 Slc22a15 Slc24a3 Slc22a16 Slc24a2 Slc6a13 Slco1b2 Slc24a1 Slc44a3 Slco2b1 Slc40a1 Slc44a4 Slc41a1 Slc44a5 Cp Slc39a4 Slc39a3 Slc5a7 Slc39a2 Slc39a1 Calm3 Slc8a1 Slc39a8 Slc22a5 Slc9a1 Slc39a7 Slc8a2 Slc39a6 Slc30a5 Slc9a4 Slc11a1 Slc9a5 Slc11a2 Slc9a2 Slc8a3 Slc9a3 Slc31a1 Slc9a8 Slc6a1 Slc9a9 Slc6a4 Slc30a8 Slc6a3 Slc1a5 Slc9a6 Slc9a7 Slc39a14 Slc30a1 Adam22 Heph Slc24a5 Slc8b1 Slc17a7 Slc4a7 Slc32a1 Slc25a1 Slc1a1 Slc5a12 Slc1a3 Slc1a2 Slc38a2 Slc1a7 Slc43a1 Slc43a2 Slc1a6 Slc6a20 Slc25a29 Slc38a1 Slc38a5 Slc3a1 Slc38a4 Slc38a3 Slc1a4 Slc7a3 Slc7a1 Slc6a6 Slc6a19 Slc6a15 Slc6a14 Slc36a2 Slc36a1 Slc16a10 Bsg Slc22a12 Slc22a6 Slc22a8 Slc22a7 Avp Slc17a5 Slc25a4 Slc2a2 Slc5a1 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-RNO-193692.1 Regulated proteolysis of p75NTR Psen2 Ncstn Traf6 Aph1a Aph1b Psenen Adam17 Rela Ngfr Psen1 Nfkb1 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 97%10228702 Calmodulin induced events Adcy8 Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%10228136 DNA replication initiation Pole3 Pole2 Prim2 Pola2 Pola1 Pole4 Prim1 Pole RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10231238 Rab regulation of trafficking Rab31 Rab35 Ccz1 Rab38 Rab3gap2 Rab3gap1 Dennd4c Dennd4a Dennd4b Rab1b Ywhae Rab5a Rab4a Dennd5a Dennd5b Als2 Hps1 Rab5c Gabarapl2 Hps4 Dennd2a Dennd2c Rab3a Dennd3 Trappc9 Trappc8 Tbc1d10c Trappc5 Trappc4 Trappc3 Trappc2 Tbc1d10b Trappc1 Tbc1d10a Map1lc3b Rab21 Rab1A Rab10 Rab13 Rab12 Rab14 Rab18 Rab3il1 Ulk1 Akt3 Rin3 Rin1 Akt2 Rin2 Akt1 Mon1b Mon1a Rab11b Optn Rab11a Rabgap1 Rinl Dennd1a Gapvd1 Dennd1b Dennd1c Trappc2l Gabarap Gdi1 Gdi2 Trappc10 Rab7a Rab33b Rab33a Rab7b Tbc1d2 Tbc1d7 Trappc12 Trappc11 Trappc13 Rab6b Rab6a Rab5b Als2cl Rab3ip Rabgef1 Chm Rab27a Rab9a Rab39a Rab9b Tbc1d14 Tbc1d13 Rab27b Tbc1d16 Tbc1d15 Tbc1d17 Trappc6b Trappc6a Rab8b Rab8a Rgp1 Ankrd27 Sytl1 Tbc1d25 Tbc1d24 Arf6 Sbf2 Chml Sbf1 Tsc2 Tsc1 Ric1 Dennd6a Dennd6b Madd NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%10231730 Nuclear RNA decay Exosc10 Mphosph6 Ncbp2 Ncbp1 Zcchc8 C1d Zfc3h1 Zc3h18 Zc3h4 Zc3h3 Ythdc2 Exosc9 Ythdc1 Exosc8 Exosc5 Rbm26 Rbm27 Exosc4 Srrt Rbm7 Exosc7 Exosc6 Exosc1 Exosc3 Exosc2 Papolg Wdr82 Dis3 Pabpn1 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%10229092 DDX58 IFIH1-mediated induction of interferon-alpha beta Ager Nkiras2 Tbk1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Mavs Ikbkg Cyld Rps27a Irf3 Nfkb2 Ikbke Nfkb1 Chuk Crebbp Uba52 Rela Irf7 Hsp90aa1 Tax1bp1 S100b Ep300 Hmgb1-ps34 Ubb Ubc Hsp90ab1 Nfkbib Nkiras1 Rig1 App Ikbkb Tomm70 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-450341.1 Activation of the AP-1 family of transcription factors Mapk10 Mapk8 Mapk11 Mapk1 Fos Mapk3 Mapk14 Mapk9 Jun Atf2 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation Ywhae Eef1a1 Ptges3 Hsp90ab1 Hsp90aa1 Vcp Hsf1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%10230626 Synthesis of 15-eicosatetraenoic acid derivatives Gpx2 Alox15 Gpx1 Alox15b Ptgs2 Gpx4 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling Hbegf Ptpn18 Btc Rps27a Akt3 Akt2 Egfr Usp8 Akt1 Cul5 Uba52 Stub1 Rnf41 Hsp90aa1 Erbb2 Ereg Egf Cdc37 Ubb Ubc Erbb3 Nrg2 Nrg1 Nrg3 Ptpn12 Ptk7 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane Pip4k2b Pip4k2c Pip4k2a Pik3c2b Arf1 Mtmr6 Ocrl Mtmr9 Pi4k2b Inpp4a Rab5a Inpp4b Rab4a Mtm1 Rufy1 Pi4k2a Synj1 Pip5k1a Pik3r1 Pik3r2 Pik3r3 Pip5k1b Mtmr14 Synj2 Inpp5k Inppl1 Mtmr3 Pik3c2a Pik3r5 Pik3r6 Pik3cg Bmx Ptpn13 Mtmr1 Inpp5d Rab14 Pik3cb Pik3cd Pik3ca Inpp5j Pten Plekha8 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Pip5k1c Pik3c2g MYOGENESIS%REACTOME DATABASE ID RELEASE 97%10229766 Myogenesis Spag9 Abl1 Mapk12 Mapk11 Cdon Ctnna1 Bnip2 Myf6 Tcf4 Ctnnb1 Myf5 Myog Cdc42 Tcf3 Cdh15 Mef2d Mef2a Myod1 Mef2b Mef2c Tcf12 Cdh2 Ctnna2 Boc Mapk14 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%10230974 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Ogg1 Polb Xrcc1 Lig3 Neil2 Neil1 Pnkp PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228398 Purine ribonucleoside monophosphate biosynthesis Impdh2 Impdh1 Gmps Adss2 Adss1 Pfas Atic Ppat Gart Paics Adsl SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193368.1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Abcd3 Akr1c3l1 Amacr Hsd17b4 Ncoa2 Baat Akr1c18 Akr1c19 Hsd3b7 Scp2 Cyp8b1 Akr1d1 Akr1c1 Akr1c21 Nr1h4 Akr1c9 Acox2 Cyp27a1 Acot8 Akr1c12l1 Slc27a5 Slc27a2 Abcb11 Cyp7a1 Rxra Akr1c12 Akr1c13 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-RNO-174430.1 Telomere C-strand synthesis initiation Terf2 Terf1 Tinf2 Ctc1 Stn1 Acd Prim2 Terf2ip Ten1 Prim1 Pot1 Pola2 Pola1 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System Dynll1 Ube2d2 Sell Copb1 Atp6v0b Nfatc3 Pgm2 Nfatc2 Dnm1 Atp6v0a4 Klrk1 Pik3c3 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Dnm3 Atp6v1c1 Atp6v0c Pdxk Pik3r4 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp11b Atp6v1g1 Atp11a Atp6v1f Atp6v1d Atp8b4 Naprt Slc2a3 Cyb5r3 Slc27a2 Prtn3 Atp7a Fcn2 Defb41 Fcn1 Defb42 Cr2 Np4 Serping1 Defb43 Defb44 Cr1l Clu Defa24 Svs3b Mbl2 Cd81 Ear1 Bpifb2 Masp1 Bpifb1 Masp2 Bpifb6 C4b Hp Bpifb4 C1qb Crp Defal1 C1qa Pglyrp1 Cfh Tlr1 Cfi Pglyrp2 C2 Reg3a C4 Pglyrp3 Reg3b Colec10 C6 Pglyrp4 C9 Defa31 Stath Cd46 C1s Reg3g Defa Cfhr1 C1r Camp Ltf Cpn1 Tlr2 Cpn2 Chga Cd19 Lyz1 Cpb2 Bpifa1 C1qc Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Defb24 Defb1 Defb25 Eppin Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Panx1 Mme Trpm2 Clec5a Siglec15 Klrd1 Klrc2 Ano6 Klrc1 Atp6ap2 Padi2 Stom Slco4c1 Tax1bp1 Relb Clec7a Clec4d Clec4e Card9 Clec6a-ps1 Tyrobp Ncf1 Ncf2 Ncf4 Brk1 Itgav Baiap2 Nck1 Nfasc Nckap1l Nckap1 Elmo2 Elmo1 Krt1 Prdx6 Mapk12 Wasf3 Mapk13 Wasf2 Wasf1 Jup Abi2 Cyba Abi1 Cybb Cyfip2 Cyfip1 Tasl Irf5 Slc15a4 Rap1a Lamtor3 Lamtor1 Lamtor2 Lpo Mpo C3ar1 Eef2 Ppbp Fpr1 Cda Fpr2 C3 C5 Arsa Asah1 Gm2a Neu1 Gla Arsb Fuca2 Ccr6 Cst3 Txk Casp9 Apaf1 Ptafr Srp14 Cfp Irf3 Cxcr1 Cxcr2 Alox5 Lta4h C5ar2 C5ar1 Acaa1b Kng1 Idh1 Cat Ttr Vapa Cand1 Capza1 Capza2 Eef1a1 Psap Frk Fuca1 Adgre5 Rab4b Hbb Fgb Cxcl1 Fga Rap1b Fgg Hmox2 Aldh3b1 Tlr10 Diaph1 Cab39 Nkiras1 App Itch Mapk9 Dtx4 Atf2 Ikbkb Atf1 Mapk7 Ilf2 Nkiras2 Mapk8 Hvcn1 Traf6 Mapk1 Peli1 Fcer1a Mavs Ikbkg Lat2 Ms4a2 Map3k8 H2az1 Rps27a Map3k7 Prcp Mapk3 Dnajc3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Rab44 Ticam1 Ecsit Skp1 Rab37 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Hspa1b Vrk3 Hspa1a Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rab3d Rps6ka1 Tifa Peli3 Rps6ka2 Dsg1 Irf7 Btrc Tlr4 Tnip2 Ckap4 Nod2 Ctsb Nod1 Ctsd Ppp2r5d Eea1 S100b Map2k7 Map2k6 Actr1b Dusp3 Dusp4 Ctsh Ctsk Hmgb1-ps34 Ubb Ctsl Ripk2 Ubc Ctss N4bp1 Dusp7 Dusp6 Gaa Agl Casp8 Pygl Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Gyg1 Irak1 Npc2 Ager Pgm1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ctsa Kpnb1 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Ikbke Cd14 ENSRNOG00000069193 Chuk Mapk10 AABR07065813.1 ENSRNOG00000062915 Mapk11 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Rhog ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Vav3 ENSRNOG00000070192 Plcg1 Iglc1 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Vav2 ENSRNOG00000065564 Stbd1 ENSRNOG00000066971 ENSRNOG00000063341 Pld1 ENSRNOG00000070986 Dock2 ENSRNOG00000065283 ENSRNOG00000062976 Commd9 ENSRNOG00000063549 ENSRNOG00000063148 Lcp2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Pak1 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 Arhgap45 ENSRNOG00000065690 ENSRNOG00000066904 Commd3 ENSRNOG00000063713 ENSRNOG00000062820 Pak2 Grap2 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Prkaca Lat Prkacb Arhgap9 ENSRNOG00000067643 Prkcd Nbeal2 Pgrmc1 Retn Lgals3 Bin2 Myo9b Dynlt1 Grn Dgat1 Ypel5 Aga Pygb Calm3 Ear1l1 Epx Bri3 Ptprb Ghdc Mospd2 Crisp2 Olfm4 Atad3a Fgl2 Hgsnat Mnda Scamp1 Cant1 Unc13d Rnase2 Pld2 Rnase3 Vat1 Tspan14 Anpep Mlec Tlr6 Cd53 Svip ENSRNOG00000064486 Unc93b1 Qpct Lgmn Tlr9 Irag2 Tlr8 Cstb Tlr7 Creg1 Cnpy3 Cd68 Cd93 ENSRNOG00000067708 Dpp7 Tarm1 Cracr2a Apeh Cpped1 Ms4a3 Rig1 Pdap1 Oscar Tmem63a Vps35l Ostf1 Mmtag2 Prdx4 Plac8 Sdcbp Ptprn2 Pa2g4 Mmp9 S100a11 Gmfg Syngr1 Actb Clec4a3 Clec4a2 Arpc1b Glipr1 Tmc6 Fcgr3a Clec4b2 Enpp4 Nfam1 Psen1 Pigr Crispld2 Dnajc13 Lilrc2 Ncstn Adgrg3 Kcmf1 Tom1 Serpinb1a Serpinb12 Serpinb10 S100a1 Gpr84 Lamp1 Arl8a Nit2 Chi3l1 Acp3 Pak3 Actg1 Dnase1l1 Cdc42 Frmpd3 Rnase17 Mcemp1 Tmem179b Tmem30a Prg3 Rock1 Prg2 Bst2 Psgb1 Rap2b Rap2c Cap1 Stk11ip ENSRNOG00000064129 Gca Mre11 Erp44 Plaur Dok3 Hebp2 Ceacam1 Kcnab2 Cotl1 Ggh Cnn2 Ddx3x Clec4a Ceacam6 Mvp Cmtm6 Tnfaip6 Ptx3 Cgm4 Pkp1 Abl1 Gstp1 Gsdme Xrcc6 Birc2 Folr2 Dsp Xrcc5 Bst1 Vnn1 Psg29 Slc2a5 H2ab2 H2ac4 Vcp Mgst1 Psmb6l1 H2ac18 Psma4 Psma3 Psma6 RT1-M6-2 Psma5 Psma2 Psma1 Cdc34 B2m Psmd12 Psmd11 Atg7 Hist1h2bq Ctnnb1 Psmd14 Psmd13 RT1-M10-ps5 Ddost Psmb5 Psmb4 Csnk2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 RT1-N3 Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 Cd36 Tubb4b H2bc18 Magt1 Psmd7 Psmd6 Ube2d3 Psmd8 Psmd2 Ube2d1 Ist1 H2bc6 H2bc4 Hist1h4m RT1-M1-5 H2bc1 Rt1-ec3 Psmd1 Huwe1 Adrm1 Hist1h2ai Ube2m Chrnb4 RT1-M5 Ptk2 Sptan1 Nras Grb2 Fyn Cfd Ubr4 Kras A1bg RT1-M2 Sos1 Hras Gsn Sh3glb2 Hrg Rbsn Olr1 Ahsg Serpina3n F12 Uba3 Serpinb6a Pnp Ampd3 Anxa2 Qsox1 Aprt Ndufc2 Lamp2 Cd177 Tnfrsf1b Fcgr1a Trim21 Mif Trim32 Orm1 AABR07044308.1 Cd47 Pla2g2a Cd63 Fcer1g Vcl Hsp90aa1 Dsc1 Sirpa Plau Pecam1 Gpi Hsp90ab1 Pgam1 Aldoc Aldoa Pfkl Crebbp Pkml1 Hk3 Pdpk1 Ormdl3 Degs1 Lyn Ep300 Yes1 Src Rhoa Ppia Cd3g Fabp5 Acly Cd4 Prkce Ptprc Lck Raf1 Agpat2 Cpne1 Cpne3 Slc11a1 Dhx9 Nos3 Nos2 Lpcat1 Nos1 Aim2 Tbk1 Galns Hexb Tollip Gsdmd Snap25 Glb1 Iqgap2 Ctsg Stat6 Ppie Syk Gab2 Vav1 Hck Pik3r1 Pik3r2 Hsp90b1 Mmp25 Adam10 Il1b Adam8 Mmp8 Try10 Prss2l1 Klkb1 Elane Shc1 Try5 Cd44 LOC102554637 Ddx41 Pik3cb Capn1 Pik3ca Myd88 Dhx36 Timp2 Prss2 Prss3 Prss1 Cdk13 Crk A2m Ptpn6 Ptpn11 Casp1 Tec Slc44a2 Ftl1 Fth1 Vamp8 Txndc5 Gusb Plpp4 Plpp5 Dnm2 Wipf3 Rab5c Wipf1 Btk Pld4 Pld3 Myo5a Fcgr2 Fgr Myh9 Myo1c Nckipsd Limk1 Fth1-ps5 Myo10 Txn Igf2r Ap1m1 Nme2 Arg1 Hspa8 P2rx7 Cd180 Tank P2rx1 Ly86 Traf3 Sarm1 Lbp Ripk3 Aoc1 Fadd Bpi Tirap Ripk1 Ptpn4 F2 Itgax Optn Gns Snap29 Snap23 Cyld Rab27a Ppp3ca Ppp3cb Rac2 Ptges2 Nfatc1 Ppp3r1 Cd209a Actr10 Cct2 Cct8 Bcl2l1 Rab31 Alad Prkcq Golga7 Chit1 Pycard Txnip Sugt1 Nlrp3 Mefv Nlrp1a Pstpip1 Dync1li1 Armc8 Arpc3 Hpse Arpc2 Impdh2 Rab3a Arpc5 Impdh1 Casp2 Arpc4 Tomm70 Tbc1d10c Aamp Trappc1 Serpina1 Rab10 Rab14 Rab18 Tubb5 Lrrc7 S100a9 S100a8 Stk10 Pafah1b2 Faf2 Rhof Actr2 Actr3 Arpc1a C1qbp Cep290 Apob Ctsc Gdi2 Rab7a Dync1h1 Dnajc5 Ctsz Nlrp4 Rab6a Rab5b Sting1 Rab9b Siglec5 Siglec8 Pla2g6 Bcl10 Itk Man2b1 Cd59 Map3k14 Cd55 Malt1 Dera Itgal Itgb2 Siglec10 Trem2 Trem1 Manba Ap2a2 Lair1 Icam2 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-RNO-432030.1 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp9 Aqp7 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-RNO-901032.1 ER Quality Control Compartment (ERQC) Ubb Ubc Uba52 Rps27a IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10230114 IL-6-type cytokine receptor ligand interactions Clcf1 Osm Osmr Cntf Crlf1 Tyk2 Cntfr Jak2 Il31ra Ctf1 Lif Il6st Lifr Il11 Il11ra1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%10231608 Regulation of CDH11 function Jup Cdh11 Adam19 Ctnnd1 Amot Ctnnb1 Angptl4 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%10230836 Repression of WNT target genes Tle4 Lef1 Tle2 Tle3 Tcf7 Tcf7l2 Tcf7l1 Ctbp1 Ctbp2 Tle1 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination Dmc1 Fignl1 Firrm Rad51 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231508 FLT3 Signaling Gab2 Pik3ca Akt3 Akt2 Pik3r1 Nras Akt1 Grb2 Kras Sos1 Hras Flt3 Grb10 Foxo3 RESPONSE TO METAL IONS%REACTOME%R-RNO-5660526.1 Response to metal ions Mt2 Mt3 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693565.1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Rad50 Eya2 Eya1 Eya4 Babam1 Eya3 Babam2 Ubxn1 Brca1 Uimc1 Hist1h2bq Tp53 Pias4 Mre11 Ube2i Kat5 Hist3h2ba Nbn Baz1b Mapk8 Chek2 H2bc6 Ube2v2 H2bc4 Bard1 Hist1h4m H2bc1 Rps27a Abl1 Ube2n Uba52 Atm Bap1 Tp53bp1 Ppp5c Apbb1 Phf6 Kdm4b Kdm4a Brcc3 Smarca5 Herc2 Ubb Rnf168 Sumo1 Ubc ABRAXAS1 Rnf8 Nsd2 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation Pip4p1 Pip4k2b Tp53 Pip4k2c Pip4k2a Ing2 Ep300 Map2k6 DEADENYLATION OF MRNA%REACTOME%R-RNO-429947.1 Deadenylation of mRNA Eif4e Paip1 Pan2 Pan3 Eif4a2 Eif4a3 Eif4a1 Pabpc1 PROLACTIN RECEPTOR SIGNALING%REACTOME%R-RNO-1170546.1 Prolactin receptor signaling Skp1 Gh1 Btrc Rbx1 Jak2 Cul1 Sh2b1 Ghr Prl Prlr MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%10228882 Mitotic Prometaphase Cenpl Dynll1 Cenpk Dynll2 Cenpi Cenph Cenpf Nup37 Ndc80 Ppp2r1b Ppp2r1a Nup107 Nup160 Ywhae Nup85 Csnk2a2 Dync1li2 Nup43 Csnk2a1 Ywhag Dync1li1 Xpo1 Ranbp2 Ppp2r5b Ppp2r5a Nup133 Csnk2b Ppp2r5e Itgb3bp Pcnt Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Prkaca Csnk1d Cep192 Eml4 Tubgcp2 Cep78 Cep76 Cep72 Cep70 Plk4 Cep57 Hdac8 Cep63 Alms1 Mzt1 Mzt2 Cep43 Cep41 Ninl Numa1 Tubb5 Odf2 Haus7 Haus8 Haus4 Haus5 Haus6 Cpap Ofd1 Haus1 Tubgcp6 Tubgcp5 Pafah1b1 Tubgcp4 Cdca5 Tubgcp3 Zw10 Pds5b Stag2 Stag1 Nedd1 Pds5a Smc1a Smc3 Wapl Pcm1 Ssna1 Tubg2 Actr1a Tubg1 Akap9 Nme7 Sfi1 Dctn1 Cetn2 Dctn2 Cep250 Rps27 Cep135 Cep131 Cdk5rap2 Cep152 Cep290 Clip1 Cep164 Ncapd2 Ncapg Smc4 Ncaph Smc2 Kif18a Ccp110 Dync1h1 Ccnb2 Ccnb1 Plk1 Cdk1 Ccnb2-ps2 Dync1i2 Dync1i1 Csnk1e Nudc Sec13 Firrm Clasp1 Clasp2 Ppp2cb Spc24 Ppp2ca Birc5 Spc25 Ercc6l Nuf2 Rangap1 Cdc20 Cdca8 Incenp Knl1 Mad2l1 Ndel1 Sgo2 Sgo1 Bub1b Ckap5 Aurkb Cenpc Hsp90aa1 Cenpa Spdl1 Pmf1 Ska2 Ska1 Ahctf1 Ppp2r5d Mapre1 Zwint B9d2 Ska2l1 Bub1 Ppp1cc Taok1 Nde1 Rcc2 Kntc1 Mad1l1 Kif2a Cenpu Kif2b Cenpt Kif2c Cenpq Cenpp Cenpo Cenpe Cenpn Cenpm Mis12 Nup98 Zwilch ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%10230330 Activation of NF-kappaB in B cells Nfkbia Cul1 Psma4 Psma3 Psma6 Chuk Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Prkcb Psmc1 Psmc4 Psmc3 Psmd7 Ikbkb Psmd6 Psmd8 Psmd2 Ikbkg Rps27a Psmd1 Adrm1 Bcl10 Nfkb1 Nfkbie Skp1 Rel Uba52 Fbxw11 Rela Malt1 Btrc Ubb Ubc Nfkbib Psmb6l1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%10228264 Aerobic respiration and respiratory electron transport Suclg2 L2hgdh Cs Fh AC132020.1 Sdhaf1 Sdhaf2 Sdhaf3 Atp5mc1 Atp5f1e Atp5f1d Aco2 Atp5pb Atp5f1c Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Ogdh Atp5mg Atp5f1b Sdhd Atp5f1a Sdhc Atp5po Sdhb Sdha Atp5mk Sucla2 Gpt Kgd4 Ranbp9 Acat1 Dlst Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Cox7a2l Cox6a1 Cox6a2 Tmem126b Uqcrfs1 Nubpl Rnf113a1 Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Higd1c Coxfa4 Cox20 Cox6c2 Cycsl2 Cyc1 Got1 Got2 Hspa9 Cox6b1 Cox8a Cox6b2 Ndufv2 Ndufv1 Cox8c Yjefn3 Ndufv3 Uqcrb Gstz1 Cox18 LOC120097699 Mt-cyb Tmem177 Uqcrh Ndufab1 Ndufc2 Ndufa12 Ndufa11 Ndufa10 Cox7b Ndufs1 Timmdc1 Ndufs3 Ndufs2 Slc25a22 Ndufs5 Cox4i1 Ndufs4 Cox4i2 Ndufs7 Ndufs6 Mt-co3 Cox7c Ndufs8 Mt-co2 Cycs Slc25a18 Slc25a11 Slc25a12 Slc25a13 Fxn Ndufa5 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Rps27a Nfs1 Idh2 Cox7a1 Sirt3 Cox7a2 Cox5a Cox5b Mt-co1 Mdh1 Mt-nd5 Mdh2 Mt-nd4 Ecsit Mt-nd6 Ndufb1 Lyrm7 Hscb Uba52 Mt-nd1 Ndufb3 Hccs Uqcrc2 Etfb Uqcrc1 Mt-nd3 Lyrm4 Ndufb5 Pdhx Mt-nd2 Etfa Ndufb8 Lyrm2 Ndufb7 Dmac2 Dmac1 Slc25a27 Ndufa3-ps3 Ucp1 Uqcr10 Ucp2 Ttc19 Pdk4 Ucp3 Pdk3 Slc25a14 Pdk2 Pdk1 Ubb Ubc Pdhb Pc Pdha1 Pdha2 Pklr Pkml1 Ldhal6b Glo1 Wdr26 Hagh Nek1 Mkln1 Fahd1 Gid4 Maea Ldha Ldhb Isca2 Ldhc Me1 Isca1 Armc8 Me3 Me2 Dld Rmnd5b Pgam5 Dlat Pdp1 Pdpr Pdp2 Vdac1 Pm20d1 Mt-atp8 Mt-atp6 Slc25a4 Idh3B D2hgdh Idh3g Idh3a Nnt Adhfe1 Trap1 Suclg1 NEDDYLATION%REACTOME%R-RNO-8951664.1 Neddylation Lrr1 Cops5 Fbxl21 Epas1 Wsb1 Hif3a Ube2d2 Cul3 Ccnf Psma4 Psma3 Hif1a Psma6 Psma5 Vhl Psma2 Psma1 Cul2 Eloc Elob Psmd12 Psmd11 Psmd14 Psmd13 Wdr5 Psmb5 Keap1 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Kbtbd7 Kbtbd8 Psma7 Fbxw4 Fbxw5 Psmc5 Fbxw7 Gan Psmc2 Fbxw8 Psmc1 Fbxw9 Psmc4 Psmc3 Fbxw2 Klhl5 Psmd7 Psmd6 Ube2d3 Klhl3 Psmd8 Klhl2 Psmd2 Ube2d1 Spsb2 Rbbp5 Spsb1 Spsb4 Rbbp7 Psmd1 Adrm1 Kctd7 Kctd6 Ube2m Nploc4 Ube2f Ufd1 Fbxo10 Cand1 Fbxo11 Fbxo15 Fbxo17 Lmo7 Nfe2l2 Lrrc41 Klhl13 Klhl11 Fbxo21 Fbxo22 Fbxo27 Fbxw17 Klhl25 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Zbtb16 Cul5 Cul7 Fbxo41 Fbxo44 Mul1 Klhl41 Fbxo40 Btbd1 Dcaf13 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Fbxo4 Fbxo6 Fbxo7 Fbxo9 Fbxl15 Fbxl16 Fbxl19 Rps27a Asb9 Asb7 Asb6 Asb5 Asb4 Asb1 Skp1 Uba52 Fbxw11 Btrc Gps1 Cop1 Ubb Ubc Uchl3 Cul1 Senp8 Nub1 Ccdc22 Ccdc8 Spsb3 Ankrd9 Socs2 Commd10 Ubxn7 Socs6 Cops3 Cops4 Dcun1d5 Cops6 Dcun1d4 Dcun1d3 Dcun1d2 Dcun1d1 Cul9 Fem1b Fem1a Cops2 Fem1c Ubd Neurl2 Commd8 Commd9 Tulp4 Dcaf8 Cops8 Dcaf4 Dcaf5 Dcaf6 Dcaf7 Dda1 Commd4 Commd5 Commd6 Commd7 Commd2 Commd3 Wdtc1 Cish Obsl1 Dcaf17 Dcaf10 Dcaf11 Skp2 Cops7a Cops7b Ddb2 Socs3 Socs5 Birc5 Nedd8 Ddb1 Cul4a Dtl Cul4b Rbx1 Vcp Psmb6l1 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-RNO-9758890.1 Transport of RCbl within the body Abcc1 Ldlrap1 Tcn2 Lrp2 Lrpl1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%R-RNO-196741.1 Cobalamin (Cbl, vitamin B12) transport and metabolism Mmab Mmadhc Mtrr Mmachc Abcc1 Cubn Ldlrap1 Lrpl1 Mtr Cblif Tcn2 Amn Lrp2 Mmut Mmaa PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622323.1 Presynaptic nicotinic acetylcholine receptors Chrnb2 Chrne Chrng Chrna4 Chrna2 Chrna1 Chrna6 Chrna5 Chrnb4 Chrnb3 Chrna3 Chrnd FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-RNO-9933937.1 Formation of the canonical BAF (cBAF) complex Bcl7c Actg1 Actl6a Smarce1 Smarcc1 Smarca2 Ss18 Smarcd1 Smarcb1 Dpf1 Smarca4 Dpf2 Dpf3 Arid1a Arid1b Ss18l1 Bcl7a Bcl7b VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%10231244 VLDLR internalisation and degradation Pcsk9 Vldlr Rps27a Ap2b1 Ubb Nr1h3 Ap2a2 Ap2s1 Nr1h2 Ap2a1 Ubc Uba52 Clta Cltc Ap2m1 Mylip REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231622 Regulation of CDH1 Gene Transcription H2bc6 Rbbp4 H2bc4 Hist1h4m Mphosph8 H2bc1 Zmym2 Rbbp7 Hdac2 Ctbp1 H2ac18 Ctbp2 Hdac1 Ezh2 Twist1 Tle1 Hist1h2ai Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Suz12 Hist1h2bq Eed H2aj H2ab2 H3-3b Hist3h2ba H2ac4 Smarca4 H2bc18 H2az2 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%10228708 Intracellular signaling by second messengers Cd28 Nedd4 Cd86 Cd80 Ezh2 Psma4 Psma3 Psma6 Mta1 Mta2 Psma5 Mta3 Psma2 Mbd3 Psma1 Csnk2a2 Kl Csnk2a1 Gab1 Fgf10 Flt3 Trib3 Fgf3 Psmd12 Fgf22 Psmd11 Chd3 Suz12 Fgf7 Gatad2a Gatad2b Psmd14 Ppp2r5b Psmd13 Trat1 Ppp2r5a Foxo6 Psmb5 Foxo4 Psmb4 Foxo1 Csnk2b Psmb7 Them4 Psmb6 Mkrn1 Psmb1 Ppp2r5e Eed Insr Psmb3 Psmb2 Psma7 Fgfr3 Psmc5 Egf Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Rbbp4 Rbbp7 Psmd1 Hgf Adrm1 Met Mecom Rps6kb2 Nr4a1 Grb2 Fyn Pdgfa Trim27 Pdgfb Otud3 Usp13 Frk Hdac2 Akt3 Hdac1 Akt2 Cd19 Akt1 Tnks2 Rnf146 Tnks Erbb2 Pip5k1b Erbb3 Nrg2 Nrg1 Nrg3 Traf6 Mapk1 Hbegf Rps27a Mapk3 Sgk1 Rac2 Ppp2cb Areg Ppp2ca Uba52 Ring1 Frs2 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Bmi1 Rnf2 Ppp2r5d Pml Ubb Prr5 Ubc Rictor Pip5k1c Irak1 Pip4k2b Ppp2r1b Pip4k2c Ppp2r1a Pip4k2a Strn Egfr Esr1 Esr2 Chuk Mapkap1 Rhog Pdpk1 Rac1 Foxo3 Ntf3 Ntf4 Lamtor5 Rptor Kit Ntrk2 Pip5k1a Akt1s1 Bdnf Lamtor3 Rraga Lamtor4 RragB Lamtor1 Src Rragc Lamtor2 Rragd Kitlg Mtor Rheb Adcy3 Cdkn1b Mlst8 Adcy4 Slc38a9 Prkce Adcy1 Adcy2 Lck Camkk1 Adcy7 Pik3r5 Pik3r6 Camkk2 Adcy8 Pik3cg Icos Adcy5 Adcy6 Adcy9 Ier3 Prkaca Phlpp1 Prkacb Prkcg Maf1 Prkcd Sall4 Pdgfrb Pdgfra Prkca Ntrk3 Camk4 Prkar1a Prkar1b Calm3 Prex2 Grk2 Usp7 Fgf16 Wwp2 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Prkar2a Fgf1 Pde1b Fgf4 Fgfr2 Pde1c Ins1 Fgf6 Pde1a Fgf5 Fgf8 Ins2 Fgf9 Klb Fgf19 Fgfr4 Ereg Fgfr1 Btc Chd4 Il1rap Gab2 Vav1 Pik3r1 Pik3r2 Pik3r3 Il33 Tgfa Pik3ap1 Irs1 Irs2 Casp9 Xiap Stub1 Irak4 Pik3cb Pik3cd Pik3ca Myd88 Pten Tsc2 Il1rl1 Ptpn11 Psmb6l1 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%10229650 RA biosynthesis pathway Rdh11 Rdh10 Rdh13 Rdh14 Adh4 Adh1 Akr1c3l1 Crabp1 Aldh1a1 Rdh7 Dhrs4 Dhrs3 Aldh1a2 Aldh1a3 Akr1c18 Akr1c19 Cyp26b1 Akr1c1 Akr1c21 Akr1c9 Dhrs9 Aldh8a1 Akr1c12l1 Sdr16c5 Cyp26c1 Akr1c12 Cyp26a1 Akr1c13 VESICLE-MEDIATED TRANSPORT%REACTOME%R-RNO-5653656.1 Vesicle-mediated transport Copa Dynll1 Dynll2 Cops5 Syt2 Kif3a Syt1 Kif3b Gorasp1 Ccz1 Kif3c Syt9 Syt8 Use1 Dennd4c Copb2 Dennd4a Dennd4b Ywhae Copb1 Cope Stam2 Kif21a Kif21b Ubqln2 Chmp3 Chmp5 Dennd5a Dnm1 Chmp7 Ubqln1 Epn2 Chmp6 Epn1 Dnm3 Dennd5b Als2 Gosr1 Fnbp1 Gosr2 Lman1l Kif20a Calr Sec24d Kif20b Kifap3 Sec24c Sec24b Dennd2a Sec24a Dennd2c Egf Reps1 Reps2 Dennd3 Cd36 Spta1 Sptbn1 Sptb Sptbn2 Alb Sptan1 Sptbn5 Sptbn4 Grb2 Ambp Apol2 Apol7bl1 Hp LOC120093819 Hpx Cd163 Msr1 Apol7al1 Apol9a Jchain Src Cd3g Cd3d Cd4 Sparc Stab1 Vamp7 Vamp2 Hsp90b1 Stx4 Prdx1 Il7r Cbl Picalm ENSRNOG00000062839 Tbc1d8b Dnajc6 Arf1 Ocrl Ftl1 Ap3b1 Fth1 Clta Apoe Ap1b1 Cltc Sh3d19 Napa Necap1 Vamp8 Golgb1 Ap1s3 Ap1s2 Txndc5 Ap1g1 Tpd52l1 Dnm2 Rab5c Gak Tpd52 Ap4e1 Hip1r Dtnbp1 Sh3gl2 Yipf6 Snapin Snx2 Ap4b1 Fth1-ps5 Arrb1 Snx9 Ttgn1 Igf2r Snx5 Ap1m2 Bloc1s1 Ap1m1 Bloc1s3 Bloc1s4 Tfrc Bloc1s6 Pik3c2a Acbd3 Pum1 Hspa8 Sort1 Cpd Lrp1 Arrb2 Apoa1 Cftr Cyth2 Cyth3 Lman1 Cyth4 Actr1a Lman2 Clvs1 Rab3il1 Vps36 Cyth1 Clvs2 Gja1 Gja3 Dctn1 Tfg Dctn2 Akt3 Hba1 Gja5 Hbb Akt2 Gja4 Dctn4 Akt1 Slc18a3 Gja8 Rab11b Optn Rab11a Vti1a Bnip1 Vps25 Vps28 Itsn1 Dennd1a Bin1 Dennd1b Dennd1c Trappc2l Itsn2 Gabarap Kdelr2 Kdelr3 Gns Gjc1 Trappc10 Gjc2 Myo6 Rab33b Rab33a Scoc Tbc1d2 Fzd4 Tbc1d7 Snf8 Trappc12 Trappc11 Trappc13 Snap29 Gjb2 Gjb1 Kdelr1 Gjb4 Gjb3 Snap23 Gjb6 App Gjb5 Arf4 Arf3 Snx18 Als2cl Kifc1 Kifc2 Rabgef1 Chm Hbegf Tmed10 Cltb Rab27a Rps27a Rab39a Tbc1d14 Tbc1d13 Rab27b Tbc1d16 Tbc1d15 Tbc1d17 Trappc6b Trappc6a Agtr1 Vamp3 Sec31b Areg Uba52 Sec31a Vamp4 Gjd2 F8 Gjd4 Gjd3 Tbc1d20 Copz2 Sytl1 Tbc1d25 Tbc1d24 Arf6 Copz1 Arf5 Golga4 Golga2 Tmf1 Chml Golga1 Gps1 Uso1 Actr10 Ubap1 Stx6 Stx5 Ston1 Ston2 Ykt6 Hmgb1-ps34 Chmp4bl1 Ubb Ric1 Ap2s1 Ubc Eps15l1 Trip10 Trip11 Arfip2 Pip5k1c Arcn1 Cenpe Rab43 Madd Tor1a Scarb1 Chmp2a Arfgap3 Chmp2b Hmgb1l2 Arfgap2 Hmgb1l1 Arfgap1 Tor1b Rab31 Ldlrap1 Nbas Rab35 Rab36 Rab38 Rab3gap2 Eps15 Rab3gap1 Egfr Scarb2 ENSRNOG00000069193 Gria1 Rab1b AABR07065813.1 Ldlr ENSRNOG00000062915 Igll1 Rabepk Arl1 ENSRNOG00000065191 Klc1 Ighl12 ENSRNOG00000062682 Dync1li2 Dab2 ENSRNOG00000070812 Rab5a ENSRNOG00000070415 Dync1li1 ENSRNOG00000070810 ENSRNOG00000066926 Rab4a Klc4 ENSRNOG00000066406 Klc3 Chrm2 ENSRNOG00000067897 ENSRNOG00000062685 Klc2 Dvl2 ENSRNOG00000070192 Bet1l Cops3 Cops4 Iglc1 Cops6 ENSRNOG00000070159 Ap4s1 ENSRNOG00000071049 Hps1 Cnih1 AABR07034736.1 Synj1 Arpc3 ENSRNOG00000065564 Cops2 ENSRNOG00000066971 Gabarapl2 ENSRNOG00000063341 Arpc2 M6pr ENSRNOG00000065283 ENSRNOG00000062976 Cnih3 ENSRNOG00000063549 Hps4 Cnih2 ENSRNOG00000063148 Cops8 Igkvl13 Rab3a Arpc5 AABR07065812.2 ENSRNOG00000063707 Aak1 Pla2g4a Arpc4 ENSRNOG00000067679 Synj2 Syt11 ENSRNOG00000070832 Galnt1 ENSRNOG00000064085 Galnt2 ENSRNOG00000064041 Dnase2 ENSRNOG00000064481 Slc2a8 ENSRNOG00000065690 ENSRNOG00000066904 Ap2m1 ENSRNOG00000063713 Sh3gl3 ENSRNOG00000062820 Col7a1 Trappc9 Ppp6c Trappc8 ENSRNOG00000064490 ENSRNOG00000066072 Sh3kbp1 Tbc1d10c AABR07065781.1 Sar1b ENSRNOG00000069901 Trappc5 ENSRNOG00000067603 Trappc4 ENSRNOG00000066431 ENSRNOG00000068499 Trappc3 Trappc2 ENSRNOG00000069940 Tbc1d10b Trappc1 ENSRNOG00000067643 Tbc1d10a Vps4a Vps4b Sh3gl1 Csnk1d Rhobtb3 Serpina1 Fnbp1l Rint1 Map1lc3b Rab21 Vps51 Vps52 Vps54 Grk2 Lrp2 Rab1A Mcfd2 Chmp4c Rab10 Rab13 Rab12 Rab14 Vps45 Rab18 Folr1 Bicd2 Bicd1 Agpat3 Bet1 Ins1 Scfd1 Fcho1 S100a9 Ins2 Fcho2 Pafah1b3 Gcc2 Pafah1b2 Pafah1b1 Ereg Zw10 Cog1 Mvb12a Cog2 Cog3 Cog4 Preb Mvb12b Cog5 Cog6 Cog7 Cog8 Necap2 Vps37a Vps37b Vps37c Vps37d Ap1g2 Ank1 Ap4m1 Actr2 Avpr2 Btc Actr3 Arpc1a Ulk1 Tmem115 Rin3 Rin1 Rin2 Arfrp1 Gja10 Stam Mon1b Mon1a Agfg1 Sec23ip Akp3 Sec16b Rabgap1 Sec16a Alpp Usp6nl Rinl Cops7a Apob Gapvd1 Cops7b Hip1 Kif18a Ctsc Kif18b Alpi Kif19 Gdi1 Ppp6r3 Alpg Gdi2 Mia2 Mia3 Rab7a Dync1h1 Rab7b Tsg101 Tf Tmed9 Ctsz Kif11 Kif12 Kif15 Kif1c Tgfa Kif1a Kif1b Dync1i2 Kif6 Rab6b Rab6a Rab5b Dync1i1 Kif9 Stx16 Stx17 Rab3ip Stx18 Kif22 Avp Kif23 Kif28 Kif27 Kif16b Rab9a Rab9b Sec13 Ap2b1 Pla2g6 Racgap1 Gbf1 Tmed2 Tmed3 Copg1 Pacsin1 Copg2 Rab8b Pacsin3 Rab8a Tmed7 Pacsin2 Rgp1 Tjp1 Ankrd28 Ankrd27 Cd59 Nedd8 Cd55 Sys1 Kif4b Kif26b Kif4a Kif26a Sec22a Wnt5a Sbf2 Adrb2 Sbf1 Nsf Napb Kif5a Kif5b Tsc2 Kif13b Tsc1 Napg Sec23a Ap2a2 Ap2a1 Hgs Tacr1 Kif2a Kif2b Kif2c Dennd6a Dennd6b Grk3 Lman2l Amph Snap91 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 Plcg1 Ntf4 Ntrk2 Bdnf SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-RNO-1660517.1 Synthesis of PIPs at the late endosome membrane Mtmr7 Pik3r4 Pikfyve Mtm1 Fig4 Vac14 Pik3c2a Pik3c3 Mtmr4 DEFENSINS%REACTOME DATABASE ID RELEASE 97%10230442 Defensins Defal1 Tlr1 Defa31 Defa Try10 Prss2l1 Tlr2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Defb24 Defb1 Defb25 Try5 Defb28 Defa9 LOC102554637 Defa8 Defb30 Defa6 Defa3 Prss2 Prss3 Prss1 Defb41 Defb42 Ccr6 Np4 Defb43 Defb44 Defa24 Cd4 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%10228740 Formation of RNA Pol II elongation complex Gtf2h5 Ercc2 Ccnh Ercc3 Eloa Cdk7 Supt6h Nelfa Nelfb Cdk9 Nelfe Ctdp1 Ncbp2 Eloc Ncbp1 Elob Supt4h1 Nelfcd Mllt3 Skic8 Mllt1 Ssrp1 Ctr9 Paf1 Leo1 Ccnk Eaf1 Eaf2 Ccnt2 Eloa2l Tcea1 Cdc73 Polr2c Polr2a Aff4 Polr2b Polr2g Polr2h Polr2e Iws1 Polr2f Mnat1 Polr2i Polr2j Ell Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 97%10228354 Metabolism of proteins Suclg2 Cs Fh Epas1 Hif3a Ube2d2 Hif1a Vhl Cul2 Eloc Elob Aco2 Ide Smad2 Smad3 Usp9x Kat2a Hdac4 Nploc4 Ufd1 Nfe2l2 Prkcsh Alb Apol2 C4b Apol7bl1 LOC120093819 Apol7al1 C4 Apol9a Safb Zfp131 Ddx17 Mbd1 Casp8ap2 Uhrf2 Cpb2 Etf1 Satb2 Atxn7 Usp3 Mul1 Usp5 Rnf128 Tada2b Otub1 Wdr48 Usp44 Usp42 Usp48 Usp47 Ifih1 Fkbp8 Usp33 Usp37 Usp22 Usp20 Usp26 Usp25 Usp24 Wdr20 Usp29 Usp28 Usp12 Usp11 Usp10 Usp16 Usp15 Usp19 Ano8 Mgat5b Pdcl Cct6b Rgs7 Thbs2 Ubxn7 Galnt3 Ggcx Bglap Ltn1 Trip4 Pelo Ascc3 Ascc2 Hbs1l Nemf Zfp598 Klhdc10 Tcf25 Rchy1 Dph5 Dph6 Rnf181 Eef2 Shprh Rad18 Rnf152 Rnf40 Rnf144a Hltf Wac Tnip3 Tnip1 Zranb1 H2ac25 Yod1 Vcpip1 Otub2 Otud7a Prmt3 Skp2 Arsa Neu2 Neu3 Neu4 Sts Stambpl1 Stambp Neu1 Arsl Mysm1 Abraxas2 Arsk Arsj Chgb Arsi Pdia6 Ccn1 Arsg Amelx Sumf1 Lgals1 Arsb Scg2 Mxra8 Sumf2 Fam20a Fam20c Fuca2 Stc2 Wfs1 Bmp4 Hrc Fbn1 Ambn Mepe Enam Bmp15 Igfbp7 Mfge8 Matn3 Rcn1 Vgf Vwa1 Prss23 Tmem132a Afp Igfbp5 Hcfc1 Igfbp4 Golm1 Igfbp1 Amtn Nucb1 Sparcl1 Cst3 Itih2 Tada3 Mcrs1 Ogt Ube2t Dtl Qtgal Adamts1 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Pofut3 Pofut4 Cdc25a Thsd4 Cfp Spon2 Npm1 Spon1 Sspo B3glct Muc19 B3gnt9 B3gnt8 B3gnt6 Muc15 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Apoa2 Galnt11 Apoe Galnt12 Gcnt7 Gcnt4 Gcnt3 Apoa5 Chst4 Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts15 Adamts16 Adamts17 Adamts18 Adamts19 Adamts10 Sbspon A4gnt Adamts12 Muc5b Muc4 Muc6 Thsd7a Adamtsl1 Adamtsl2 Slc34a1 Adamtsl3 Adgrf5 Adamtsl4 Dmbt1 Adamtsl5 Galnt9 Slc34a2 Adamts20 Sftpa1 Thsd7b Ttf1 Lmcd1 Sftpb Napsa Sftpd Ccdc59 Sftpc Gata6 Zdhhc2 Gpc3 Cand1 Slc25a5 Eef1d Eef1a1 Eef1b2 Eef1g Chst10 Mgat5 Mgat2 Mgat1 Mgat3 St6gal1 Manea Man1c1 Fut8 Smc6 Fuca1 Smc5 Man1a2 Sp140 Man1a1 St8sia6 Nsmce4a Man2a1 Hic1 Man2a2 Eid3 Nsmce1 Mgat4c Nsmce2 Mgat4a Sp3 Mgat4b St8sia3 Mageb10 Sp100 Top2b Top2a Top1 Ttll6 Ttll7 Ttll4 Ttll5 Ttll10 Ttll2 Fn1 Ttll3 Ttll11 Fga Ttll12 Ttll8 Fgg Ttll13 Ttll9 Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Otulin Dhps Eif5a Fn3k Fn3krp Eif5a2 Dohh Slc35c1 Slc35a1 App Traf6 Ikbkg Rps27a Idh2 Map3k7 Psmg1 Psmg4 Ube2n Psmg3 Psmd10 Nfkb2 Bdh1 Pomp Psmd5 Oxct1 Psmd4 Traf2 Rab44 Rab2b Rab34 Skp1 Rab37 Rab20 Uba52 Ring1 Ptp4a2 Fbxw11 Rab23 Rab26 Phc2 Rab25 Rab29 Rab40b Rela Phc1 Rab15 Rab17 Cbx4 Rab19 Cbx2 Phc3 Rab3c Rab3b Rab3d Sin3a Mettl22 Etfbkmt Bmi1 Kin Mettl21a Btrc Eef2kmt Eef1akmt2 Eef1akmt1 Tnip2 Nod2 Josd2 Nod1 Josd1 Rnf2 Pml Tdg Ubb Ripk2 Ubc ENSRNOG00000067174 Pappa Klk6 Ngfg Pcsk9 Nfkbia Pappa2 Igfbp6 Igfals ENSRNOG00000066972 Igfbp2 Afg3l2 Usp14 Cul1 Spg7 Pmpca Usp18 Tab1 Pias3 Sumo2 Ikbke Pheta2 Oxsm Htra2 Lonp1 Clpp Iars2 Clpx Nub1 Ccdc22 Shmt2 Ccdc8 Spsb3 Ankrd9 Socs2 Commd10 Socs6 Dcun1d5 Rpa1 Dcun1d4 Dcun1d3 Dcun1d2 Dcun1d1 Cul9 Fem1b Fem1a Fem1c Ubd Neurl2 Commd8 Commd9 Tulp4 Dcaf8 Dcaf4 Dcaf5 Dcaf6 Dcaf7 Dda1 Commd4 Commd5 Commd6 Commd7 Commd2 Commd3 Wdtc1 Cish Obsl1 Dcaf17 Dcaf10 Dcaf11 Prkaca Calm3 Pomc Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Stag2 Stag1 Smc1a Smc3 Pex2 Pex14 Pex13 Pex12 Fcgr3a Lypd6b Cd109 Rtn4rl2 Gpld1 Pigc Lypd8 Tecta Pigb Akp3 Lypd5 Lypd4 Alpp Lypd3 Negr1 Tex101 Lypd2 Piga Lypd1 Alpl Pigk Pigm Alpi Pigl Pigg Alpg Pigf Pigh Opcml Psgb1 Tectb Dpm1 Dpm2 Dpm3 Otoa Plaur Izumo1r Ly6g6d Ceacam1 Cd52 Prss21 Nrn1 Ntm Ceacam6 Gp2 Xpnpep2 Meltf Gpihbp1 Cgm4 Thy1 Art4 Art3 Atrnl1 Lsamp Reck Sprn Plet1 Pigs Pigu Pigt Prkn Pign Pigq Ube2l3 Pigp Psca Spaca4 Cntn4 Pigw Msln Mdga1 Cntn3 Mdga2 Birc2 Folr2 Pigv Pigx Bst1 Vnn1 Cntn5 Gpaa1 Psg29 Ly6e Ly6h Pgap1 Satb1 Prnd Ly6d Prss41 Ppa1 Ppa2 Polb Parp1 H2ac4 Rbx1 Vcp Mvd Psmb6l1 Lrr1 Psme2 Cops5 Psme1 Psmb10 Fbxl21 Wsb1 H2ac18 Cul3 Psma4 Ccnf Psma3 Psma6 Psma5 Psma2 Psma1 Cdc34 B3gnt3 Csnk2a2 Csnk2a1 Rnf123 Psmd12 Psmd11 Suz12 Hist1h2bq Psmd14 Psmd13 Wdr5 Psmb5 Siah2 Psmb4 Keap1 Csnk2b Psmb7 Psmb6 Psmb1 Ube2g2 Psmb3 Calr Psmb2 Ube2g1 Kbtbd7 Psma7 Kbtbd8 Fbxw4 Psmc5 Fbxw5 Fbxw7 Psmc2 Gan Psmc1 Fbxw8 Psmc4 Fbxw9 Psmc3 Fbxw2 Klhl5 Psmd7 Psmb9 Psmd6 Klhl3 Psmb8 Psmd8 Psmd2 Klhl2 H2bc6 Spsb2 Rbbp5 Spsb1 H2bc4 Hist1h4m H2bc1 Spsb4 Rbbp7 Psmd1 Adrm1 Kctd7 Hist1h2ai Kctd6 Ube2w Ube2m Ube2k Pdia3 Ube2b Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Spta1 St8sia4 Lrrc41 Klhl13 Klhl11 Ube2z Sptbn1 Sptb Fbxo21 Sptbn2 Fbxo22 Sptan1 Sptbn5 Sptbn4 St8sia2 Fbxo27 Uba6 Fbxw17 Klhl25 Ube2e3 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Zbtb16 Uqcrq Uba1 Cul5 Cul7 Fbxo41 Fbxo44 Hspa9 Ndufv1 Klhl41 Yjefn3 Ndufv3 Fbxo40 Btbd1 Mt-cyb Ndufab1 Fbxo2 Asb12 Asb14 Ndufs1 Asb13 Asb16 Ndufs3 Asb15 Asb18 Asb17 Ube2r2 Fbxo4 Fbxo6 Mt-co3 Fbxo7 Mt-co2 Fbxo9 Fbxl15 Fbxl16 Fbxl19 Cox5a Asb9 Cox5b Asb7 Asb6 Mt-co1 Asb5 Mt-nd5 Mdh2 Asb4 Mt-nd4 Mt-nd6 Asb1 Mt-nd1 Uqcrc2 Etfb Mt-nd3 Mt-nd2 Klk13 Taf9b Taf10 Sphk1 Rhoa Cp Slc30a5 Slc30a8 Hnrnpc Hnrnpk Ctsg Il33 Hsp90b1 Canx Socs3 Socs5 Csf1 Il6 P4hb Arf1 Napa Vcan Golgb1 Rab5c Arrb1 Ttgn1 Txn Hspa8 Traf3 Ripk1 Arrb2 Proc F2 Serpinc1 Serpind1 Ar Tnc Apoa1 Dmp1 Eif2s3 Eif2s2 Eif2s1 Cftr Abca3 Lman1 Actr1a Lman2 Dctn1 Tfg Dctn2 Dctn4 Tnks2 Rab11b Axin2 Rab11a Rnf146 Trappc2l Tnks Kdelr2 Kdelr3 Usp34 Trappc10 Rab33b Leo1 Rab33a Kdelr1 Arf4 Arf3 Usp21 Usp2 Chm Usp4 Tmed10 Cyld Otud7b Rab27a Rab39a Rab27b Trappc6b Trappc6a Nagk Gnpnat1 Amdhd2 Sec31b Uap1 Gfpt1 Areg Gfpt2 Sec31a Pgm3 Renbp F8 Tbc1d20 Copz2 Copz1 Arf5 Golga2 Chml Gps1 Uso1 Actr10 Stx5 Cop1 Ykt6 Mdm4 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Arcn1 Large1 Rab43 Large2 Pomgnt1 Fktn Amfr Engase Arfgap3 Ngly1 Rad23b Arfgap2 Nfrkb Arfgap1 Foxk2 Rab31 Foxk1 Uchl3 Uchl5 Rab35 Kdm1b Rab36 Ino80e Rab38 Ino80d Tfpt Ino80c Ino80b Actr5 Actr8 Ruvbl1 Gria1 Rab1b Senp8 Asxl1 Mbd5 Mbd6 Uchl1 Dync1li2 Asxl2 Ino80 Rab5a Dync1li1 Rab4a Becn1 Bet1l Cops3 Cops4 Cops6 Cnih1 Cops2 Cnih3 Cnih2 Cops8 Rab3a Galnt1 Galnt2 Tomm20 Vdac2 Vdac3 Vdac1 Col7a1 Tomm70 Trappc9 Ppp6c Sar1b Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Csnk1d Serpina1 Mrtfa Rab21 Rab1A Mcfd2 Rab10 Rab13 Rab12 Rab14 Rab18 Folr1 Bet1 Ins1 Scfd1 Ins2 Cog1 Cog2 Cog3 Cog4 Rnf20 Cct6a Preb Cog5 Cog6 Cog7 Senp1 Cog8 Ank1 Tmem115 Cct7 Stam Sec23ip Sec16b Sec16a Cops7a Apob Cops7b Ctsc Ppp6r3 Mia2 Mia3 Ccp110 Rab7a Dync1h1 Rab7b Tf Tmed9 Ctsz Tgfa Dync1i2 Riox2 Rab6b Rab6a Rab5b Dync1i1 Stx17 Jmjd6 Rab9a Rab9b Sec13 Bcl10 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Rab8b Rab8a Tmed7 Ankrd28 Cd59 Nedd8 Cd55 Sec22a Adrb2 Nsf Napb Pten Napg Sec23a Hgs Lman2l Copa Dynll1 Dynll2 Gorasp1 Copb2 Copb1 Cope Stam2 Atxn3 Foxo4 Gosr1 Gosr2 Lman1l Sec24d Sec24c Sec24b Sec24a Rpl4 Pccb Rps14 Rps15 Rpl5 Rps16 Nadk2 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Bpifb2 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Rps21 Rps23 Rps24 LOC100910714 Rps15a Dcaf13 Rps4x-ps13 Megf11 LOC120093247 Bche Ero1b Rpl36a Rps3a Ces1d Cpa3 Mme Rps27l Exoc3 Exoc4 Exoc5 Exoc6 Rplp2 Sec11c Exoc1 Exoc2 Sec11a AABR07072440.1 Ren1 Ace2 Enpep Rpl35al8 Exoc7 Rps26-ps13 Exoc8 Mboat4 Rpl22l1 Atp6ap2 Ffar4 Rplp0 Gzmf Rplp1 Dpp4 Rpl13a Gh1 Rpl35al2 Ghrl Pla2g7 Rpl18a Spcs3 Ace Rpl13 Spcs1 Rpl14 Spcs2 Igf1 Pcsk1 Rpl15 Lep Gpr119 Inhbb Rpl17 Cpb1 Inhbc Rpl18 Inhbe Rpl19 Ppara Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x Mitf Cdh2 Nop58 LOC134480579 Tfap2c Fau Rpl23a Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Nup205 Pom121 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Tp53 Rraga Eif4ebp1 Eif4e Eif5 Eif1ax Eif4a2 Eif4a1 Pabpc1 Eif5b Eif4h Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Eif2b3 Eif2b2 Eif2b5 Eif2b4 Eif2b1 Adora2b Adora2a Sema5a Lhb C3 Cga Ltbp1 Tgfbr1 Fshb Ddb2 Twnk Ssbp1 Igf2 Mief1 Mtrf1l Mt-atp8 Gfm1 Gfm2 Srp68 Mrrf Mt-atp6 Srp9 Mrps9 Mrps2 Mrps7 Mrps5 Mt-nd4l Srp54 Dap3 Mrpl54 Penk Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Grp Mrpl46 Mrpl48 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Gcg Mrpl22 Mrpl23 Mrpl24 Mrpl27 Agt Mrpl28 Srp14 ENSRNOG00000068816 Eral1 Srp19 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Gadd45gip1 Mrpl20 Mrpl3 Mrpl4 Adra2a Mrpl1 Mrpl2 Adra2c Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Atp5f1c Atp5pd Atp5pf Atp5mg Atp5f1b Atp5f1a Atp5po Skic8 Ctr9 Paf1 Ffar1 Ech1 Kng1 Hspd1 Acot1 Acot2 Acot5 Acot3 Ldhd Pex5 Pex10 Mbtps1 Gip Trim27 Otud3 Usp13 Rab4b P2ry2 Adamts3 Adamts2 Adamts14 Tshb Cdk1 Tfam Pias1 Dnajc3 Muc13 Ktn1 Ckap4 Ctsd F10 F9 Ctsh Pros1 Pcna Ctsa Pomt1 B3galnt2 Pomt2 Pomk Pomgnt2 Usp30 Park7 Lipt1 Lipt2 Nfu1 Lias Usp7 Fgf23 Rgs9 Camkmt Apeh Rig1 Mmp2 Sdc2 Actg1 Pias4 Ube2i Blm Ube2v2 Bard1 Prkdc Clspn Xrcc4 Tpst1 Tpst2 Bap1 Ccna1 Ccna2 Tp53bp1 Ddb1 Cul4a Cul4b Brcc3 Herc2 Rnf168 Sumo1 ABRAXAS1 Sumo3 Rad52 Mat2b Babam1 Aldh1b1 Babam2 Ubxn1 Brca1 Mta1 Uimc1 Apc Axin1 Inha Smad1 Smad4 Ube2d3 Ube2d1 Inhba Smurf2 Fstl1 Smad7 Chrdl1 Usp8 Cdc73 Pcgf2 Notum F7 Gas6 Hdac2 Ctbp1 Ahsg Spp2 Hdac1 Qsox1 Serpina10 Snx3 Thbs1 Scg3 Nrip1 Proz Pdk1 Aplp2 Mmrn1 Nr1h3 Nr1h2 Pdhb Rxra Pgr Gata3 Esr1 Rara St8sia5 Pnpla2 Dld Ep300 Kat2b Yy1 Dlat Nr5a2 Eci1 Star B3gnt5 B3gnt7 B3gnt2 B4galt4 B4galt5 B4galt6 St3gal6 St3gal4 St3gal2 Srd5a3 St3gal3 B4gat1 St6galnac5 St3gal1 St6galnac6 B4galt2 B4galt3 Glb1 Vdr Men1 Hmgcs2 St3gal5 Nr1h4 Senp5 Senp5l1 Uba2 Rwdd2b Fdx1 Sae1 Senp2 Cmas Alg9 Alg8 Alg6 Alg5 Alg3 Alg2 Alg1 Adam10 Gmds Gne Nus1 Pmm2 ENSRNOG00000069479 Pmm1 Nudt14 Umod Npl Dhrsx Asgr2 Adamts5 Asgr1 Slc17a5 Adamts4 Nanp Nans St8sia1 Mpi St6galnac3 Dhdds Dolpp1 Fuom St6gal2 Dolk Alg13 Alg14 Alg12 Mpdu1 Fpgt Gmppa Plg B4galnt2 Fcsk St6galnac1 St6galnac2 Dpagt1 Gfus Spp1 Furin Cma1 Timp1 Myc Mmp1b Ing2 AC132020.1 Glud1 Ogdh Gcsh Acadsb Arg2 Nr5a1 Nr3c2 Nr3c1 Kgd4 Hsd17b10 Acat1 Aldh18a1 Trim28 Thrb Thra Dlst Acad8 Nr1i2 L3mbtl2 Daxx Dbt Rabggta Rabggtb Dnmt1 Ube2s Ube2c Ube2e1 Cct3 Cct2 Tcp1 Cct8 Igfbp3 Cct5 Cct4 Hadh Icmt Fech Alas1 Rce1 ENSRNOG00000067432 Nlrp3 Actl6a Me2 Suds3 Rab2a Cetn2 Pcmt1 Msra Msrb1 Msrb3 Msrb2 Pias2 Aldh2 Xpc Rad23a Birc5 Rangap1 Cdc20 Cdca8 Incenp Idh3a Aurkb BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 97%10231446 Biosynthesis of DPAn-6 SPMs Alox15 Alox12 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-RNO-9933947.1 Formation of the non-canonical BAF (ncBAF) complex Bcl7c Actg1 Actl6a Smarcc1 Smarca2 Ss18 Smarcd1 Smarcd3 Smarcd2 Smarca4 Bicral Bicra Brd9 Ss18l1 Bcl7a Bcl7b TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 97%10228584 Transport of Mature mRNAs Derived from Intronless Transcripts Slbp Nup58 Cpsf4 Nup37 Nup205 Pom121 Cpsf1 Cpsf2 Nup107 Sec13 Nup188 Cpsf3 Tpr Nup160 Rae1 Ndc1 Nup85 Ncbp2 Ncbp1 Nup42 Nup62 Nup43 Nup88 Sympk Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nxf1 Fip1l1 Eif4e Nup93 Nup50 Nup35 Alyref Nup54 Nup98 IMMUNOGLOBULIN MATURATION%REACTOME%R-RNO-9938026.1 Immunoglobulin maturation Actr1a Pold3 Rev1 Dynll1 Msh6 Dynll2 Msh2 Rilp Kif3a Ctsa Mcm3ap Kif3b RT1-DOa RT1-DOb Dctn1 Osbpl1a Kif3c Pms2 Dctn2 Mlh1 Rev3l Apex2 Poli Polh Dctn4 Klc1 Dync1li2 Dync1li1 Klc4 Klc3 Klc2 Kif18a Ctsc Kif20a Rab7a Dync1h1 Kifap3 Kif11 Kif15 RT1-Db2 RT1-Db1 Dync1i2 RT1-Ha Dync1i1 RT1-Ba RT1-Bb Kif22 RT1-Da Kif23 Rps27a Racgap1 Uba52 Kif4b Kif4a Kif26a Ctsb Ctsd Ctnnbl1 Actr10 Ctse Kif5a Sptbn2 Ctsf Kif5b RT1-DMb Actr1b Ctsh Ctsk Ctsl Ubb Ctso Ctss Ubc Exo1 Ifi30 Aicda Kif2a Rfc5 Kif2b Pold2 Kif2c Rfc3 Mad2l2 Cenpe Rfc4 Pcna Rfc1 Rfc2 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231284 MET activates PTK2 signaling Met Itga2 Megf11 Lama4 Hgf Itgb1 Ptk2 Src Itga3 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%10228688 phospho-PLA2 pathway Pla2g4a Mapk1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10230064 Zinc transporters Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc30a8 Slc39a8 Slc39a7 Slc39a14 Slc30a1 Slc39a6 Slc30a5 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi St8sia6 Man2a1 Man2a2 Mgat4c St3gal4 Mgat4a Mgat4b St8sia3 B4galt2 B4galt3 St8sia2 Chst10 Mgat5 Mgat2 Mgat3 St6gal1 B4galt4 B4galt5 B4galt6 Fut8 Fuca1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%10228816 Activation of BID and translocation to mitochondria Nmt1 Bid Casp8 Gzmb REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%10229224 Removal of the Flap Intermediate from the C-strand Pold3 Terf2 Terf1 Rpa1 Tinf2 Fen1 Rpa2 Acd Pold1 Terf2ip Rpa3 Pot1 Pold4 Pold2 Dna2 Wrn Pcna GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity Cacng8 Cacng4 Cacng2 Prkcg Cacng3 Ap2b1 Prkca Grip2 Gria1 Gria4 Camk2a Gria3 Gria2 Epb41l1 Pick1 Akap5 Dlg1 Myo6 Nsf Dlg4 Tspan7 Ap2a2 Ap2s1 Ap2a1 Prkcb Camk2g Camk2d Camk2b Ap2m1 Grip1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-RNO-202733.1 Cell surface interactions at the vascular wall Itgb3 Sell ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Plcg1 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 Slc7a11 Itga6 L1cam ENSRNOG00000065283 Lyn Mag ENSRNOG00000062976 Yes1 Slc7a10 ENSRNOG00000063549 Spn Src ENSRNOG00000063148 Itga3 Ppil2 Igkvl13 Slc16a3 AABR07065812.2 Slc16a8 Ppia ENSRNOG00000063707 ENSRNOG00000067679 Slc7a6 Slc7a7 ENSRNOG00000070832 Atp1b1 ENSRNOG00000064085 Atp1b3 ENSRNOG00000064041 Atp1b2 Slc16a1 ENSRNOG00000064481 ENSRNOG00000065690 Slc7a8 ENSRNOG00000066904 Slc7a9 Lck ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Dok2 ENSRNOG00000067643 Slc7a5 Proc F2 Itgb1 Selplg Itgax Nras Grb2 Fyn Kras Sos1 Glg1 Hras Olr1 Gas6 Jam3 Jam2 Fn1 Grb14 Apob Esam Cd177 Pik3r1 Slc3a2 Pik3r2 Ceacam1 Cd244 Mertk Bsg Thbd Mif Cxadr Cd74 Cd48 Cd47 Cav1 F11r Procr Epcam Inpp5d Shc1 Grb7 Sele Cd44 Jaml Selp Jchain Itga4 Pik3cb Itgal Sirpa Pik3ca Pecam1 Itgb2 Angpt1 Angpt2 Pf4 Angpt4 Trem1 Fcamr Mmp1b Pros1 Tek Itgav Ptpn6 Ptpn11 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 97%10230272 IRAK1 recruits IKK complex Peli2 Chuk Traf6 Peli3 Peli1 Ikbkg Ube2n Ikbkb Irak1 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%10231594 LDL remodeling Mttp P4hb DEGRADATION OF GABA%REACTOME%R-RNO-916853.1 Degradation of GABA Aldh5a1 Abat PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-RNO-428559.1 Proton-coupled neutral amino acid transporters Slc36a1 Slc36a2 ENOS ACTIVATION%REACTOME%R-RNO-203615.1 eNOS activation Nos3 Akt1 Zdhhc21 Cyb5b Spr Calm3 Cav1 Hsp90aa1 Lypla1 Ddah1 Cygb ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-RNO-8963889.1 Assembly of active LPL and LIPC lipase complexes Angptl3 Lipc Pcsk5 Angptl8 Gpihbp1 Lmf1 Furin Pcsk6 Lmf2 Lpl Angptl4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-RNO-69202.1 Cyclin E associated events during G1 S transition Cables1 Cdc25a Ccnh Skp2 Ccnd1 Cdk4 Rb1 Cdk7 Cul1 Akt3 Psma4 Psma3 Akt2 Psma6 Psma5 Akt1 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cdk2 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ptk6 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Rps27a Psmd1 Adrm1 Skp1 Uba52 Ccne1 Ccne2 Ccna1 Ccna2 Cks1b Mnat1 Ubb Ubc Wee1 Psmb6l1 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-RNO-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation Psmb8 Psmb5 Psmb4 Psme2 Psme1 Psmb7 Psmb6 Psmb1 Psmb10 Psmb3 Psmb2 Psma4 Psma3 Psma6 Psma7 Psma5 Psma2 Psma1 Psmb9 Psmb6l1 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%10230636 Abacavir metabolism Nt5c2 Adh1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 97%10230070 GP1b-IX-V activation signalling Gp1bb Gp1ba Raf1 Ywhaz Gp5 Gp9 Src Pik3r1 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230682 Scavenging by Class A Receptors Msr1 Hsp90b1 Apoe Calr Apoa1 Apob SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 97%10230632 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp1b1 Cyp2c66 Cyp2j16 Cyp2c11 Cyp2j3 Cyp1a1 Ephx2 Cyp1a2 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%10230796 RIPK1-mediated regulated necrosis Sdcbp Peli1 Prkn Rps27a Ube2l3 Mlkl Traf2 Pdcd6ip Birc2 Ogt Ripk3 Fadd Uba52 Ripk1 Xiap Stub1 Hsp90aa1 Cdc37 Ubb Flot2 Flot1 Ubc Casp8 Itch Tradd Fas Cflar Faslg Tnfsf10 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 97%10230134 TRAF6-mediated induction of TAK1 complex within TLR4 complex Traf6 Tlr4 Rps27a Map3k7 Tab3 Tab2 Ticam2 Tab1 Cd14 Ticam1 Ubb Sarm1 Ubc Uba52 Ly96 Irak2 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%10230954 RHO GTPases activate KTN1 Cdc42 Klc1 Rhog Klc4 Klc3 Kif5a Rac1 Kif5b Klc2 Ktn1 Rhoa CARNITINE SHUTTLE%REACTOME%R-RNO-200425.1 Carnitine shuttle Prkag2 Ppard Mid1ip1 Slc25a20 Slc22a5 Rxra Cpt1a Thrsp Cpt1b Prkab2 Cpt2 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 97%10231182 Intra-Golgi traffic Cyth1 Rab39a Rab36 Arf1 Akp3 Vti1a Alpp Rgp1 Napa Bet1l Vps45 Alpi Gosr1 Alpg Gosr2 Rab33b Nsf Napb Stx6 Stx5 Ykt6 Napg Cog1 Ric1 Cog2 Snap29 Cog3 Cog4 Trip11 Cog5 Cog6 Cog7 Cyth2 Cog8 Cyth3 Stx16 Cyth4 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%10228138 Synthesis of DNA Pold3 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Pole3 Pole2 Mcm7 Mcm8 Pola2 Pola1 Psmd12 Pole4 Psmd11 Orc5 Orc4 Orc6 Psmd14 Orc1 Psmd13 Orc3 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Rpa1 Rpa2 Psmb7 Cdc6 Psmb6 Psmb1 Prim2 Rpa3 Cdk2 Psmb3 Psmb2 Prim1 Mcm3 Mcm4 Mcm5 Psma7 Pole Mcm2 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Psmd1 Adrm1 Skp2 Gins2 Gins1 Gins4 Gins3 Dna2 Rps27a Skp1 Uba52 Ube2s Ccne1 Ccne2 Ube2c Cdc27 Cdc26 Ccna1 Cdc23 Ccna2 Anapc10 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Fen1 Lig1 Anapc2 Fzr1 Anapc7 Ube2e1 Pold1 Cdc16 Pold4 Ubb Ubc Rbx1 Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Psmb6l1 Rfc2 SCAVENGING OF HEME FROM PLASMA%REACTOME DATABASE ID RELEASE 97%10230646 Scavenging of heme from plasma LOC120093819 Hpx Cd163 Apol7al1 Apol9a Hba1 Hbb ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 Lrp1 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Jchain Apoa1 Alb Ambp Apol2 Apol7bl1 Hp MITOPHAGY%REACTOME DATABASE ID RELEASE 97%10230852 Mitophagy Mterf3 Tbk1 Prkn Rps27a Ube2l3 Ulk1 Ube2n Ube2d2 Map1lc3b Sqstm1 Csnk2a2 Optn Uba52 Csnk2a1 Csnk2b Src Mfn1 Mfn2 Ubb Map1lc3a Ubc Fundc1 Pink1 Pgam5 Tomm7 Atg5 Tomm40 Atg12 Tomm22 Tomm20 Vdac2 Vdac3 Vdac1 Tomm70 Ube2d3 Atg9a SIALIC ACID METABOLISM%REACTOME%R-RNO-4085001.1 Sialic acid metabolism Npl St8sia6 St3gal6 Slc17a5 St3gal4 Ctsa St3gal2 Nanp Nans St8sia3 St8sia1 St6galnac3 St3gal3 St6galnac5 St6galnac6 St3gal1 St6gal2 Neu2 Glb1 Neu3 Neu4 St6galnac1 St6galnac2 Neu1 St8sia5 St8sia4 St3gal5 Cmas Slc35a1 St8sia2 St6gal1 Gne GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228256 Galactose catabolism Pgm1 Galk1 Galt Gale Galm MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%10231296 MET interacts with TNS proteins Met Tns4 Tns3 Hgf Itgb1 DOWNSTREAM TCR SIGNALING%REACTOME%R-RNO-202424.1 Downstream TCR signaling Nfkbia Prkcq Cul1 Ube2d2 Tab2 Psma4 Psma3 Psma6 Chuk Psma5 Psma2 Psma1 Cdc34 Psmd12 Psmd11 Pdpk1 Psmd14 Psmd13 Trat1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Pik3r1 Psma7 Pik3r2 Psmc5 RT1-Db2 Psmc2 Cd247 Psmc1 Cd3g Psmc4 RT1-Db1 Psmc3 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Psmd7 Ikbkb RT1-Ba Psmd6 RT1-Bb ENSRNOG00000065955 Psmd8 Ube2d1 Trbv16 Psmd2 RT1-Da Traf6 Ikbkg Rps27a Map3k7 Psmd1 Ube2n Adrm1 Bcl10 Nfkb1 Skp1 Uba52 Fbxw11 Inpp5d Rela Malt1 Btrc Pik3cb Pik3ca Pten Ubb Ripk2 Ubc Psmb6l1 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-RNO-5675482.1 Regulation of necroptotic cell death Sdcbp Peli1 Prkn Rps27a Ube2l3 Mlkl Traf2 Pdcd6ip Birc2 Ogt Ripk3 Fadd Uba52 Ripk1 Xiap Stub1 Hsp90aa1 Cdc37 Ubb Flot2 Flot1 Ubc Casp8 Itch Tradd Fas Cflar Faslg Tnfsf10 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229846 Orexin and neuropeptides FF and QRFP bind to their respective receptors Hcrtr2 Hcrtr1 Qrfprl Qrfpr Hcrt Npffr1 Npffr2 Qrfp Npff RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network Rab9a Rab9b Rhobtb3 Arfrp1 Vamp3 Rabepk Arl1 Vps51 Vps52 Vps54 Vti1a Vamp4 Usp6nl Rgp1 Napa Sys1 Golga4 Tmf1 Golga1 Nsf Napb Scoc M6pr Gcc2 Stx6 Napg Cog1 Ttgn1 Ric1 Cog2 Igf2r Cog3 Cog4 Arfip2 Cog5 Rab6b Cog6 Rab6a Cog7 Rab43 Cog8 Stx16 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%10231652 MITF-M-dependent gene expression Sin3a Sytl2 Myrip Tcf7l2 Rab27a Myo5a Mitf Hdac1 Hint1 Lef1 Tcf7 Tcf7l1 Ctnnb1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%10231438 Pre-NOTCH Transcription and Translation Elf3 Prkci TRIGLYCERIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228524 Triglyceride metabolism Fabp2 Fabp3 Pnpla4 Fabp4 Fabp7 Fabp9 Fabp6 FABP12 Dgat2 Gk Lpin3 Lpin2 Gpam Gpd2 Dgat1 Agmo Mogat1 Fabp5 Gpat2 Mogat2 Gykl1 Fabp1 Pnpla5 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition Actr1a Tubg1 Dynll1 Akap9 Aurka Sfi1 Ppp2r1a Dctn1 Cetn2 Cul1 Dctn2 Bora Cep250 Ajuba Ppp1cb Cep135 Cep131 Cdk5rap2 Ywhae Cep152 Optn Cep290 Cep164 Ywhag Ccp110 Dync1h1 Ccnb2 Ccnb1 Plk1 Pcnt Cdk1 Dync1i2 Ccnb2-ps2 Tuba4a Tubb4b Nek2l1 Tubb4a Tuba1a Csnk1e Prkaca Rps27a Csnk1d Cep192 Clasp1 Skp1 Cep78 Cep76 Cep72 Uba52 Cep70 Rab8a Fbxw11 Plk4 Cep57 Cep63 Alms1 Cep43 Cep41 Ninl Ckap5 Tubb5 Hsp90aa1 Btrc Odf2 Haus7 Ppp1r12b Haus8 Haus4 Ppp1r12a Haus5 Haus6 Ofd1 Haus1 Mapre1 Cpap Pafah1b1 Ubb Nde1 Ubc Nedd1 Pcm1 Ssna1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-RNO-5696397.1 Gap-filling DNA repair synthesis and ligation in GG-NER Pold3 Rpa1 Rpa2 Pold1 Rps27a Rpa3 Pold4 Pole Polk Ubb Pole3 Pole2 Ubc Uba52 Rfc5 Pold2 Pole4 Rfc3 Rfc4 Pcna Rfc1 Rfc2 MAPK6 MAPK4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229860 MAPK6 MAPK4 signaling Mapkapk5 Hspb1 Cdc14a Psma4 Psma3 Psma6 Psma5 Psma2 Kalrn Psma1 Cdc42ep2 Cdc42ep3 Psmd12 Psmd11 Xpo1 Rac1 Psmd14 Psmd13 Foxo3 Pak3 Cdc42 Psmb5 Psmb4 Foxo1 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Dnajb1 Psmc5 Ncoa3 Psmc2 Psmc1 Psmc4 Pak1 Psmc3 Cdk1 Cdc14b Psmd7 Pak2 Psmd6 Psmd8 Septin7 Psmd2 Mapk6 Mapk4 Etv4 Prkaca Rps27a Prkacb Psmd1 Adrm1 Uba52 Ccnd3 Ubb Ubc Psmb6l1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 97%10231356 G beta:gamma signalling through CDC42 Gng8 Gngt1 Cdc42 Gnb2 Gnb1 Arhgef6 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Pak1 Gng3 Gng10-ps1 Gng5 Gng4 Gng7 ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport Slc67a1 Slc25a26 Slc14a2 Slc14a1 Slc47a1 Slc22a15 Slc22a16 Slc22a2 Slc22a1 Slc22a3 Slc22a5 Slc22a4 Runx1 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Nras Grb2 Kras Sos1 Hras Fgf10 Fgf3 Fgf22 Shc1 Fgf7 Fgf16 Fgf17 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%10230468 Acyl chain remodeling of CL Pla2g4a Tafazzin Lclat1 Hadha Hadhb REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231330 Regulation of PTEN gene transcription Rbbp4 Rbbp7 Chd4 Hdac2 Maf1 Sall4 Hdac1 Ezh2 Mta1 Mta2 Mta3 Mbd3 Ring1 Mecom Phc2 Cbx6 Chd3 Suz12 Phc1 Gatad2a Cbx4 Gatad2b Cbx2 Phc3 Bmi1 Lamtor5 Rptor Eed Rnf2 Lamtor3 Rraga Lamtor4 RragB Lamtor1 Rragc Lamtor2 Rragd Mtor Rheb Mlst8 Slc38a9 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-RNO-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk7 Kcnk1 Kcnk6 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228514 Wax and plasmalogen biosynthesis Awat1 Agps Gnpat Far2 Far1 Dhrs7b Awat2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%10230338 Antiviral mechanism by IFN-stimulated genes Nedd4 Tarbp2 Npm1 Ppp2r1b Actb Ppp2r1a Fnta Irf3 Fntb Adar Usp18 Chuk Ube2l6 Ppm1b Mx2 Eif2ak2 Arih1 Trim25 Becn1 Isg15 Flnb Ppp2r5a Actg1 Plcg1 Tp53 Sphk1 Cdk1 Ikbkb Pim1 Gbp5 Hspa8 Ilf2 Ilf3 Snca Mavs Ikbkg Faap100 Hspa2 Dnajc3 Mapk3 Stat3 Ube2n Fancl Stat1 Fancm Ptpn2 Fanca Fancb Fancc Fance Fancf Fancg Ppp2cb Dus2 Ppp2ca Hspa1b Hspa1a Pggt1b Furin Hspa1l Gbp2 Dhx9 Gbp1 Gbp3 Faap24 Faap20 Ube2e1 Map2k6 Sfn Pde12 Uba7 Rig1 Rnasel Oasl Nck1 Mapt Prkra Casp1 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-RNO-5610785.1 GLI3 is processed to GLI3R by the proteasome Psmd8 Psmd2 Csnk1a1 Prkaca Rps27a Prkacb Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Btrc Gli3 Psmb1 Psmb3 Psmb2 Gsk3b Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Sufu Psmd7 Psmd6 Psmb6l1 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228326 Carnitine synthesis Aldh9a1 Tmlhe Shmt1 Bbox1 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 97%10231160 Regulation of PTEN localization Ubb Nedd4 Ubc Uba52 Xiap Rps27a Usp7 Pten Pml PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 Afg3l2 Mcub Pmpcb Spg7 Micu2 Pmpca Micu3 Micu1 Parl Pheta2 Phb1 Maip1 Mcu Yme1l1 Stoml2 Phb2 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) Psmd8 Psmd2 Cops5 Rps27a Cul1 Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Skp1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Btrc Psmb1 Psmb3 Psmb2 Gsk3b Cd274 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Rbx1 Nek2l1 Psmd7 Psmd6 Psmb6l1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%10228188 p53-Dependent G1 DNA Damage Response Psmd8 Psmd2 Chek2 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Ccne1 Psmd12 Ccne2 Psmd11 Atm Ccna1 Psmd14 Ccna2 Psmd13 Psmb5 Psmb4 Psmb7 Tp53 Psmb6 Psmb1 Psmb3 Cdk2 Phf20 Psmb2 Psma7 Psmc5 Cop1 Ubb Mdm4 Psmc2 Zfp385a Psmc1 Ubc Psmc4 Psmc3 Cdkn1b Psmd7 Psmd6 Psmb6l1 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-RNO-8948216.1 Collagen chain trimerization Col26a1 Col25a1 Col2a1 Col14a1 Col27a1 Col10a1 Col3a1 Col23a1 Col28a1 Col22a1 Col5a2 Col15a1 Col5a3 Col13a1 Col8a1 Col24a1 Col8a2 Col18a1 Col5a1 Col19a1 Col20a1 Col11a1 Col7a1 Col11a2 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-RNO-9013973.1 TICAM1-dependent activation of IRF3 IRF7 Irf7 Irf3 IMMUNE SYSTEM%REACTOME%R-RNO-168256.1 Immune System Ube2d2 Vhl Cul2 Eloc Elob Atp6v0b Flt3 Trib3 Pgm2 Atp6v0a4 Grb10 Pik3c3 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Them4 Pik3r4 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp11b Atp6v1g1 Atp6v1f Atp11a Atp6v1d Atp8b4 Rnf111 Slc27a2 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Masp1 Masp2 C4b Hp C1qb Crp C1qa Cfh Cfi C2 C4 Colec10 C6 C9 Cd46 C1s Cfhr1 C1r Cpn1 Cpn2 Cd19 Cpb2 C1qc Trpc1 Trpm2 Clec5a Siglec15 Klrd1 Klrc2 Ano6 Klrc1 Padi2 Stom Slco4c1 Tax1bp1 Wwp1 Relb Clec7a Clec4d Clec4e Card9 Clec6a-ps1 Prr5 Ncf1 Ncf2 Ncf4 Rictor Brk1 Itgav Baiap2 Nck1 Nckap1l Nckap1 Elmo2 Elmo1 Prdx6 Mapk12 Wasf3 Mapk13 Wasf2 Wasf1 Jup Mapkap1 Abi2 Cyba Abi1 Cybb Cyfip2 Cyfip1 Tasl Irf5 Slc15a4 Rap1a Lpo Mpo Ltn1 Rchy1 Ywhab Sfn Eef2 Skp2 Arsa Asah1 Gm2a Neu1 Gla Arsb Fuca2 Cst3 Txk Casp9 Apaf1 Ghr Prl Prlr Csf3 Cfp Npm1 Irf3 Alox5 Lta4h Ttr Cand1 Capza1 Capza2 Eef1a1 Tnfsf14 Tnfsf12 Tnfrsf11a Tnfrsf13c Tnfrsf12a Ltb Ltbr Fuca1 Hbb Fgb Fga Rap1b Fgg Rapgef4 Rapgef3 Rasgrp1 Rasgrp2 Hmox2 Aldh3b1 Tlr10 Diaph1 Cab39 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Fcer1a Ikbkg Lat2 Ms4a2 Map3k8 H2az1 Rps27a Prcp Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Rab44 Ticam1 Ecsit Skp1 Rab37 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rab3d Rps6ka1 Tifa Peli3 Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d Eea1 S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mylip Mapkapk2 Irak2 Npc2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Kpnb1 Ppp2r1b Ppp2r1a Kpna1 Usp14 Cul1 Tab3 Tab2 Adar Usp18 Tab1 Nlrc5 Ikbke Cd14 Chuk Mapk10 Mapk11 Rhog Stbd1 Pld1 Dock2 Commd9 Arhgap45 Commd3 Prkaca Prkacb Arhgap9 Prkcd Nbeal2 Pgrmc1 Retn Lgals3 Bin2 Myo9b Dynlt1 Grn Ypel5 Aga Pygb Calm3 Ear1l1 Epx Bri3 Ptprb Ghdc Mospd2 Crisp2 Olfm4 Atad3a Fgl2 Hgsnat Mnda Scamp1 Cant1 Unc13d Rnase2 Pld2 Rnase3 Vat1 Tspan14 Anpep Mlec Tlr6 Cd53 Svip ENSRNOG00000064486 Qpct Irag2 Cstb Creg1 Cd68 Cd93 ENSRNOG00000067708 Dpp7 Tarm1 Cracr2a Cpped1 Ms4a3 Pdap1 Oscar Tmem63a Vps35l Ostf1 Mmtag2 Prdx4 Plac8 Ptprn2 Pa2g4 S100a11 Gmfg Syngr1 Clec4a3 Clec4a2 Glipr1 Tmc6 Fcgr3a Clec4b2 Enpp4 Nfam1 Pigr Crispld2 Dnajc13 Lilrc2 Adgrg3 Kcmf1 Tom1 Serpinb1a Serpinb12 Serpinb10 S100a1 Gpr84 Lamp1 Arl8a Nit2 Chi3l1 Acp3 Dnase1l1 Frmpd3 Rnase17 Mcemp1 Tmem179b Tmem30a Prg3 Prg2 Bst2 Psgb1 Rap2b Rap2c Cap1 Stk11ip ENSRNOG00000064129 Gca Erp44 Plaur Dok3 Hebp2 Ceacam1 Kcnab2 Cotl1 Ggh Cnn2 Ddx3x Clec4a Ceacam6 Mvp Cmtm6 Tnfaip6 Ptx3 Cgm4 Prkn Pkp1 Ube2l3 Gsdme Birc2 Folr2 Dsp Bst1 Vnn1 Psg29 Stub1 Slc2a5 H2ab2 Rnf185 Prkaa1 Derl3 Derl2 H2ac4 Stt3b Rbx1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Psmb6l1 Prkag1 Lrr1 Prkag2 Nedd4 Ost4 Psme2 Cops5 Psme1 Ccnd1 Tmem258b Rnf220 Tusc3 Cbll1 Cdk4 Psmb10 Kmt2a Fbxl21 Kmt2c Rnf213 Wsb1 H2ac18 Cul3 Rnf217 Ezh2 Hecw2 Psma4 Ccnf Psma3 Cblb Psma6 RT1-M6-2 Erlec1 Sh3rf1 Trim11 Psma5 Psma2 Ube2l6 Mex3c Psma1 Cdc34 B3gnt3 Csnk2a2 B2m Dad1 Dcaf1 Csnk2a1 Rnf126 Ywhag Rnf123 Psmd12 Cd207 Psmd11 Ubac1 Lnpep Suz12 Atg7 Hist1h2bq Psmd14 Rnf114 Psmd13 Rnf115 Hace1 Wdr5 RT1-M10-ps5 Ash2l Ddost Siah1 Psmb5 Siah2 Psmb4 Keap1 Csnk2b Dzip3 Psmb7 Mrc2 Psmb6 Mrc1 Psmb1 Mkrn1 Ube2g2 Eed Psmb3 Calr Psmb2 Ube2g1 Gsk3b Rnf138 RT1-N3 Cd274 H2aj Kbtbd7 Os9 Rnf130 Psma7 Kbtbd8 Fbxw4 H3-3b Psmc5 Fbxw5 Hist3h2ba Fbxw7 Psmc2 Gan Psmc1 Fbxw8 Psmc4 Fbxw9 Psmc3 Cd36 Anapc13 Pdcd1 Det1 Rnf5 Sel1l Fbxw2 H2bc18 Klhl5 Rbck1 Nek2l1 Arih2 Magt1 Psmd7 Rlim Psmb9 Psmd6 H2az2 Klhl3 Psmb8 Psmd8 Psmd2 Klhl2 H2bc6 Ube4a Spsb2 Rbbp5 Trim9 Rbbp4 Spsb1 H2bc4 Hist1h4m Trip12 RT1-M1-5 H2bc1 Spsb4 Rbbp7 Rt1-ec3 Mib2 Psmd1 Lrsam1 Huwe1 Pdcd1lg2 Adrm1 Ube2j2 Ube2j1 Prkab2 Kctd7 Hist1h2ai Prkab1 Ube2u Kctd6 Ube2w Ube2m Ube2k Rnf182 Ube2o Pdia3 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Chrnb4 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 Sptbn2 RT1-M5 Ptk2 Fbxo22 Sptan1 Ubox5 Ubr1 Rnf19a Nras Ubr2 Grb2 Fyn Glmn Ubr4 Kras RT1-M2 Fbxo27 Sos1 Hras Uba5 Uba6 Uba7 Trim69 Fbxw17 Trim71 Klhl25 Ube2e3 Ube2e2 Klhl21 Rnf19b Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Hspa5 Uba1 Uba3 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Ndufc2 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fcgr1a Fbxo9 Trim21 Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Asb1 Lnx1 Ppl Dsc1 Gpi Pgam1 Aldoc Aldoa Pfkl Pkml1 Hk3 Ormdl3 Degs1 Sphk1 Lyn Yes1 Src Rhoa Zap70 RT1-Db2 Cd247 Ppia Cd3g RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Ptprc Lck Ptpn22 Icoslg RT1-Ba Pik3r5 RT1-Bb Pik3r6 ENSRNOG00000065955 Pik3cg Icos Trbv16 RT1-Da Ifngr2 Ifng Ifngr1 Raf1 Jak2 Slc11a1 Dhx9 Nos3 Nos2 Prkg1 Nos1 Itpr1 Aim2 Il12b Il12a Il36a Crkl Stxbp2 Tbk1 Il23r Cntf Il20rb Il23a Il20ra Cntfr Il1rn Tslp Ebi3 Il31ra Il12rb1 Il12rb2 Tollip Lif Il1f10 Stx1a Gsdmd Stat5a Snap25 Stat5b Il36g Sdc1 Il10 Il11 Ctsg Stat6 Il15 Il13 Ppie Il1rap Il18 Il16 Il22ra2 Osmr Csf2rb Ifnlr1 Jak3 Vamp7 Tyk2 Syk Gab2 Vamp2 Vav1 Hck Il18r1 Pik3r1 Pik3r2 Pik3r3 Il33 Il6st Il34 Il10rb Hsp90b1 Il10ra Canx Stx4 Stx3 Inppl1 Il21 Il22 Il18bp Il11ra1 Il20 Il24 Clcf1 Osm Il27 Crlf1 Il1rapl1 Il1a Il22ra1 Rapgef1 Il1b Stat3 Stat1 Ctf1 Socs1 Socs3 Irs1 Irs2 Socs5 Lifr Ybx1 Sqstm1 Txlna Map3k3 Il36rn Csf1 Csf2 Inpp5d Brwd1 Shc1 Il2 Il4 Il3 Il6 Csf1r Il5 Il7 Il9 Irak4 Irak3 Ddx41 Pik3cb Il6r Pik3cd Il4r Pik3ca Myd88 Ptprz1 Il18rap Il2ra Il2rb Il15ra Il13ra2 Il1rl2 Il1rl1 Smarca4 Sos2 Il7r Crk Ywhaz Ptpn6 Cbl Ptpn11 Ifnl1 Casp3 Ptk2b Prkra Casp1 Ifnl3 Tec Il1r2 P4hb Il1r1 Tarbp2 Il9r Xdh Arf1 Ftl1 Fth1 Clta Ap1b1 Cltc Vamp8 Ap1s3 Ap1s2 Txndc5 Gusb Plpp4 Ap1g1 Plpp5 Dnm2 Wipf3 Rab5c Wipf1 Btk Pld4 Pld3 Myo5a Fcgr2 Fgr Sh3gl2 Myh9 Myo1c Nckipsd Limk1 Fth1-ps5 Myo10 Txn Igf2r Ap1m2 Ap1m1 Nme2 Hspa8 P2rx7 Cd180 Tank P2rx1 Ly86 Itpr3 Traf3 Sarm1 Itpr2 Ripk3 Lbp Bpi Fadd Ripk1 Tirap Ptpn4 F2 Itgax Actr1a Dctn1 Dctn2 Akt3 Akt2 Dctn4 Akt1 Optn Gns Snap29 Snap23 Tnf Cyld Rab27a Ptges2 Vamp3 Sec31a Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Actr10 Ap2s1 Cenpe Rab31 Klc1 Dync1li2 Ppm1b Dync1li1 Mx2 Eif2ak2 Arih1 Klc4 Trim25 Klc3 Becn1 Isg15 Klc2 Flnb Arpc3 Hpse Arpc2 Rab3a Arpc5 Arpc4 Ap2m1 Tomm70 Sh3kbp1 Tbc1d10c Sar1b Trappc1 Serpina1 Rab10 Rab14 Rab18 S100a9 S100a8 Stk10 Pafah1b2 Faf2 Rhof Actr2 Actr3 Arpc1a C1qbp Apob Kif18a Ctsc Gdi2 Rab7a Dync1h1 Ctsz Kif11 Kif15 Dync1i2 Rab6a Rab5b Dync1i1 Kif22 Kif23 Sting1 Cxadr Rab9b Siglec1 Sec13 Siglec5 Ap2b1 Siglec8 Pla2g6 LOC100910497 Bcl10 Racgap1 Pik3ap1 Nfkbie Fyb1 Slamf6 Slamf7 Rel Itk Hcst Kir3dl1 Pilrb2l4 Ctla4 Ifitm1 Ifitm2 Ifitm6 Pilrb1l3 Cd59 Pilrb1l2 Map3k14 Rap1gap Cd55 Jaml Kif4b Malt1 Pilrb-ps7 Kif4a Cd160 Itga4 Kif26a Btla Itgal Itgb7 Stim1 Pianp Itgb2 Siglec10 Kif5a Pten Trem2 Kif5b Trem1 Cd226 Nectin2 Cd101 Ifitm3-ps2 Sec23a Ap2a2 LOC134481331 Ap2a1 Lair1 Icam1 Icam5 Kif2a Icam4 Kif2b Icam2 Cd79a Kif2c Cd79b Treml2 Treml4 Cd200 Cd1d ifitm3 Cd28 Cd22 Dynll1 Cd40 Dynll2 Cd34 Kif3a Sipa1 Cd200r1l Kif3b Madcam1 Pvr Cd40lg LOC120093164 Kif3c Cd86 Cd80 Rap1gap2 Cd96 Crtam Sell Vcam1 Cd8b Cd8a Copb1 Cd300le Cd300ld Cd300lg Cd300lf Dapp1 Nfatc3 Nfatc2 Klrb1a Dnm1 Klrk1 Clec4g Blnk Trat1 Clec2e Dnm3 Pdxk Kif20a Sec24d Kifap3 Sec24c Sec24b Sec24a Naprt Slc2a3 Cyb5r3 Prtn3 Atp7a Defb41 Defb42 Np4 Defb43 Defb44 Defa24 Svs3b Ear1 Bpifb2 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Tlr1 Pglyrp2 Reg3a Pglyrp3 Reg3b Pglyrp4 Defa31 Stath Reg3g Defa Camp Ltf Tlr2 Chga Lyz1 Bpifa1 Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Defb24 Defb1 Defb25 Eppin Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Panx1 Mme Atp6ap2 Gh1 Tyrobp Nfasc Krt1 Tp53 Lamtor3 Lamtor1 Lamtor2 Fkbp1a Mtor Mlst8 C3ar1 Ppbp Fpr1 Fpr2 Cda C3 C5 Ccr6 Ptafr Srp14 Cxcr1 Cxcr2 C5ar2 C5ar1 Acaa1b Kng1 Idh1 Cat Vapa Psap Frk Adgre5 Rab4b Cxcl1 Prkcb Cdk1 Itch Dtx4 Pim1 Pias1 Gbp5 Ilf2 Ilf3 Hvcn1 Ifna4l1 Snca Mavs Faap100 Ifna1l1 Ifi44 Hspa2 Dnajc3 Fancl Ifnb1 Fancm Fanca Fancb Fancc Fance Fancf Fancg Dus2 Ifna4 Ifna1 Irf9 Hspa1b Hspa1a Pggt1b Ifnar1 LOC120103158 LOC120103159 Hspa1l Ifnar2 Gbp2 Gbp1 Gbp3 Faap24 Faap20 Dsg1 Ifi44l Ckap4 Ctsb Ctsd Ctnnbl1 Ctse Ctsf RT1-DMb Actr1b Ctsh Ctsk Ctsl Ctso Ctss Exo1 Ifi30 Aicda Gaa Agl Rfc5 Pygl Pold2 Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 Gyg1 Pold3 Pgm1 Rev1 Msh6 Msh2 Rilp Ctsa Mcm3ap RT1-DOa RT1-DOb Osbpl1a Pms2 Mlh1 Rev3l Apex2 Poli Polh ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 Rac1 ENSRNOG00000067897 ENSRNOG00000062685 Vav3 ENSRNOG00000070192 Plcg1 Iglc1 Plcg2 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Vav2 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000070986 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Lcp2 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Pak1 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 Pak2 Grap2 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Lat ENSRNOG00000067643 Dgat1 Itgb1 Unc93b1 Lgmn Tlr9 Tlr8 Tlr7 Cnpy3 Csk Apeh Pde12 Rig1 Rnasel Oasl Sdcbp Mmp9 Actb Arpc1b Psen1 Ncstn Pak3 Actg1 Cdc42 Rock1 Mre11 Ube2v2 Abl1 Gstp1 Xrcc6 Xrcc5 Herc2 Sumo1 Mgst1 Ctnnb1 Ppp2r5b Ppp2r5a Ppp2r5e Tubb4b Ube2d3 Ube2d1 Ist1 Smurf2 Smurf1 Ptpn2 Ptpn1 Cfd A1bg Gsn Mapt Sh3glb2 Hrg Rbsn Olr1 Ahsg Serpina3n F12 Serpinb6a Pnp Ampd3 Anxa2 Qsox1 Aprt Tnfsf4 Tnfsf13b Eda Tnfrsf17 Tnfrsf25 Tnfrsf4 Lamp2 Tnfsf11 Tnfsf8 Cd177 Tnfrsf8 Edaradd Tnfsf9 Edar Tnfrsf1b Tnfsf15 Tnfsf13 Tnfrsf9 Tnfrsf1a Tnfrsf11b Tnfsf18 Lta Eda2r Tnfrsf18 Sh2b1 Mif Orm1 Cd74 Lag3 Cd47 Pla2g2a Cd63 Fcer1g Vcl Hsp90aa1 Sirpa Plau Pecam1 Hsp90ab1 Crebbp Pdpk1 Foxo3 Fkbp5 Ep300 Fabp5 Acly Prkce Agpat2 Cpne1 Cpne3 Lpcat1 Galns Hexb Glb1 Iqgap2 Mmp25 Adam10 Adam8 Mmp8 Try10 Prss2l1 Klkb1 Elane Furin Try5 Cd44 LOC102554637 Capn1 Dhx36 Timp2 Prss2 Prss3 Prss1 Cdk13 A2m Slc44a2 Arg1 Aoc1 Ppp3ca Ppp3cb Rac2 Nfatc1 Ppp3r1 Camk2a Ube2s Ube2c Cdc27 Cdc26 Cdc23 Anapc10 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Anapc7 Ube2e1 Cdc16 Cct2 Cct8 Bcl2l1 Alad Prkcq Golga7 Fnta Fntb Chit1 Pycard Txnip Sugt1 Nlrp3 Mefv Nlrp1a Pstpip1 Armc8 Impdh2 Impdh1 Casp2 Pag1 Aamp Tubb5 Lrrc7 Cep290 Dnajc5 Nlrp4 Camk2g Camk2d Camk2b Man2b1 Cdc20 Dera Manba SIGNALING BY RETINOIC ACID%REACTOME%R-RNO-5362517.1 Signaling by Retinoic Acid Rdh11 Rdh10 Rdh13 Rdh14 Adh4 Pdha1 Adh1 Pdha2 Akr1c3l1 Crabp1 Crabp2 Aldh1a1 Rdh7 Dhrs4 Rara Pdhx Dhrs3 Aldh1a2 Aldh1a3 Ppard Akr1c18 Akr1c19 Cyp26b1 Akr1c1 Akr1c21 Akr1c9 Pdk4 Dld Pdk3 Dhrs9 Aldh8a1 Pdk2 Akr1c12l1 Pdk1 Sdr16c5 Rarg Fabp5 Pdhb Rxrb Cyp26c1 Rxra Dlat Akr1c12 Cyp26a1 Akr1c13 Rxrg NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975956.1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Ncbp2 Ncbp1 Pabpc1 Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rpl6 Rps13 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rps25 Gspt2 Rps26 Gspt1 Rps27 Rps28 Rps29 Rpl27a Rpl31l15 Rps20 Upf1 Rps21 Etf1 Rps23 Rps24 LOC100910714 Rps15a Rps4x-ps13 LOC120093247 Rpl36a Rps3a Rps27l Rplp2 AABR07072440.1 Rpl35al8 Rps26-ps13 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Uba52 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rps4x LOC134480579 Ubc Fau Rpl23a PROLINE CATABOLISM%REACTOME%R-RNO-70688.1 Proline catabolism Aldh4a1 Prodh1 Prodh2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines Mthfd1 Shmt1 Mthfd2 Mthfd2l Dhfr Slc19a1 Folr2 Aldh1l1 Aldh1l2 Fpgs Mthfs Shmt2 Mthfr Slc25a32 Slc46a1 Mthfd1l FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Galnt3 Fgf5 Fgf8 Fgf9 Fgfr3 Fgf16 Fgf17 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%10229214 Glycosaminoglycan metabolism Chp1 B3gnt3 Fam20b Idua Ncan Bgn Cspg5 Cspg4 Xylt1 Vcan Xylt2 Hyal4 Hyal3 Ids Papss2 Hyal1 Hs3st4 Papss1 Hs3st1 Gusb Extl2 Hs3st2 Naglu Hs3st5 Hs3st6 B3galt6 Hs3st3b1 Hpse2 Hpse Hs2st1 Ndst1 Ndst2 Ndst3 Ndst4 Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Sgsh Ext2 Ext1 Sdc4 Sdc3 Gpc1 Gpc3 Gpc2 Gpc4 Gpc6 Agrn Slc9a1 Abcc5 Gpc5 Glb1l B3gnt7 B3gnt2 Kera B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Fmod Glb1l2 St3gal6 Galns St3gal4 St3gal2 Hexa Lum Hexb St3gal3 B4gat1 Omd St3gal1 Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Glb1 Ogn Sdc1 Sdc2 Chst11 Chst12 Chsy1 Chsy3 Arsb Chst13 Chst14 Gns Uxs1 Chst15 Dse Chpf Csgalnact2 Chst7 Chst9 Dsel Ust Slc35d2 Slc35b3 Slc35b2 Slc26a2 Slc26a1 Slc26a11 Slc17a5 Dcn Bcan Cd44 Hyal2 Chp1l1 Has1 Has2 Has3 Cemip Pxylp1 B4galt7 Ctsl Hyal5 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-RNO-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Tbk1 Tlr4 Rps27a Ticam2 Ikbke Cd14 Tank Ticam1 Traf3 Ubb Ubc Optn Uba52 Ly96 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-RNO-5578749.1 Transcriptional regulation by small RNAs Ago2 H2bc6 Ago1 H2bc4 Hist1h4m H2bc1 Ran Ipo8 H2ac18 Hist1h2ai Hist1h2bq Polr2c Polr2a Polr2b H2aj Polr2g Polr2h H2ab2 Polr2e H3-3b Polr2f Hist3h2ba Polr2i H2ac4 Polr2j H2bc18 Tnrc6a H2az2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation Peli2 Chuk Traf6 Peli3 Peli1 Ikbkg Ube2n Ikbkb Irak1 TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling Pik3cb Dok2 Pik3ca Angpt1 Angpt2 Angpt4 Pik3r1 Pik3r2 Nras Grb2 Grb14 Kras Tek Sos1 Hras Shc1 Ptpn11 Grb7 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-RNO-445095.1 Interaction between L1 and Ankyrins Sptbn4 Ank1 Spta1 Sptbn1 Sptb L1cam Sptbn2 Sptan1 Sptbn5 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-RNO-9634638.1 Estrogen-dependent nuclear events downstream of ESR-membrane signaling Akt1 Mapk1 Cdkn1b Xpo1 Akt3 Akt2 Uhmk1 Foxo3 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-RNO-9855142.1 Cellular responses to mechanical stimuli Pkn2 Itgb3 Nfkbia Ppp2r1b Ppp2r1a P2ry2 Ikbke Chuk Akt1 Mapkap1 Pdpk1 Adm Anxa2 Mtor Ppp2r2a Gng10-ps1 Mlst8 Ikbkb Gnas Ikbkg Calcrl Prkaca Prkacb Abl1 Stat1 Trpv4 Nfkb1 Ptpn1 Gna11 Prkar1a Prkar1b Ppp2ca Calm3 Gng3 Gng5 Rela Gng4 Itgb1 Gnaq Vcl Gng7 Pde4d Gng8 Gngt1 Prkar2a Gnb2 Yap1 Gnb1 Gnb4 Gnb3 Capn2 Gnb5 Ptk2 Gng11 Gng12 Nos3 Prr5 Capns1 Rictor Itgav Ramp2 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229062 G-protein activation Gng8 Gngt1 Gnb2 Gnb1 Gnb4 Oprm1 Gnb3 Gnb5 Gng11 Gng12 Gna11 Gna14 Pdyn Gng3 Gng10-ps1 Pomc Gng5 Gng4 Gnaq Gng7 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 97%10228972 Telomere Extension By Telomerase Shq1 Terf2 Dkc1 Terf1 Nhp2 Pif1 Tinf2 Gar1 Wrap53 Ppp6r3 Nop10 Acd Rtel1 Tert Terf2ip Cdk2 Pot1 Ankrd28 Ccna1 Ccna2 Ppp6c SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 97%10231222 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Ube2d1 Uchl3 Usp9x Rps27a Ube2l3 Ube2d2 Uba1 Ube2w Ube2k Cdc34 Uba52 Ube2b Ube2s Usp7 Ube2a Ube2c Usp5 Otulin Ube2t Ube2e1 Ube2g2 Ube2z Ube2g1 Ubb Ube2r2 Ubc Uba6 Ube2e3 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress Nup58 Nup37 Nup205 Hsph1 Pom121 Rps19bp1 Nup107 St13 Nup188 Tpr Cryab Nup160 Hspa5 Hsbp1 Rae1 Ywhae Ndc1 Bag5 Bag3 Crebbp Nup85 Sirt1 Bag2 Bag1 Nup42 Nup62 Nup43 Hspa9 Nup88 Aaas Hspa14 Hspa13 Nup214 Ranbp2 Hikeshi Nup155 Hsf1 Nup133 Nup210 Nup153 Rpa1 Fkbp4 Rpa2 Hspb8 Ptges3 Hspa4 Dnajc2 Rptor Rpa3 Akt1s1 Gsk3b Hspa12b Ep300 Hspa12a Dnajb6 Dnajb1 Mtor Mlst8 Camk2g Camk2d Camk2b Hspa8 Mapk1 Hspa2 Mapk3 Sec13 Camk2a Hspa1b Hspa1a Hspa1l Hsp90aa1 Eef1a1 Hsp90ab1 Nup93 Nup50 Vcp Nup35 Mapkapk2 Nup54 Nup98 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229162 Classical antibody-mediated complement activation Crp C1qa C1s C1r ENSRNOG00000069193 AABR07065813.1 C1qc ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C1qb HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance Hdlbp Cubn Amn Apoa1 Scarb1 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 97%10230552 IPs transport between nucleus and cytosol Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 RHO GTPASES ACTIVATE CIT%REACTOME%R-RNO-5625900.1 RHO GTPases activate CIT Cit Prc1 Rhoc Rhob Dlg4 Rac1 Kif14 Rhoa SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 97%10231136 Signaling by MST1 Mst1 Hpn Spint2 Spint1 Mst1r MIRO GTPASE CYCLE%REACTOME%R-RNO-9715370.1 Miro GTPase Cycle Mfn1 Mfn2 Trak1 Myo19 Trak2 Rhot2 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 97%10231306 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Actl6b Pbrm1 Smarcd1 Smarcb1 Smarcd3 Smarcd2 Csnk2a2 Ring1 Csnk2a1 Phc2 Cbx6 Arid1a Arid1b Phc1 Cbx4 Cbx2 Phc3 Actl6a Bmi1 Csnk2b Yaf2 Smarce1 Smarcc1 Smarca2 Rnf2 Pcgf5 Ep300 Smarca4 Cbfb Runx1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells Akt1 Foxo1 Akt3 Akt2 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines Psmd8 Psmd2 Azin2 Psmd1 Azin1 Odc1 Adrm1 Psma4 Psma3 Amd1 Psma6 Psma5 Nqo1 Psma2 Psma1 Psmd12 Psmd11 Oaz1 Oaz3 Psmd14 Oaz2 Psmd13 Sat1 Psmb5 Smox Psmb4 Psmb7 Psmb6 Psmb1 Srm Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Agmat Psmd7 Psmd6 Psmb6l1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG Daglb Abhd12 Mgll Dagla Abhd6 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 97%10228506 RNA Polymerase II Transcription Initiation And Promoter Clearance Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Taf4b Taf7l-ps1 Gtf2a1 Cdk7 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Taf4 Gtf2e1 Taf2 Taf1 Gtf2e2 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Taf9b Polr2j Taf15 Taf11 Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 97%10229854 Alpha-oxidation of phytanate Slc27a2 Aldh3a2 Phyh Pecr Hacl1 APOPTOTIC EXECUTION PHASE%REACTOME%R-RNO-75153.1 Apoptotic execution phase Add1 Plec Hmgb1l2 Hmgb1l1 Kpnb1 Prkcq Kpna1 Fnta Lmna Casp6 Lmnb1 Cdh1 Ctnnb1 Dsg2 Rock1 Apc Stk26 Stk24 Pkp1 Prkcd Ocln Hmgb2 Clspn Bmx Dnm1l Birc2 Dsp Dsg3 Tjp1 Acin1 Satb1 Bcap31 Dffa Dffb Tjp2 Dsg1 Ptk2 Sptan1 Hmgb1-ps34 H1-1 H1-0 Casp8 H1-5 Casp7 Gsn H1-4 Gas2 H4f3 Casp3 Vim Mapt Sh3glb2 RHOH GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231406 RHOH GTPase cycle Nipsnap2 Rhoh Stom Osbpl11 Uaca Mtr Tmem59 Jup Vamp3 Fam91a1 Cav1 Dbt Arhgdib Nsfl1c Arhgdig Ralgapa1 Wdr11 Tuba1b Rock2 Slc1a5 Rock1 Rab7a Arhgdia Pak4 Lamtor1 Zap70 Csk Pak1 Pak6 Pak5 Slc4a7 Vcp Tfrc Lck Pak2 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%10231126 Neutrophil degranulation Dynll1 RT1-M6-2 Sell Psma5 Psma2 Copb1 B2m Psmd12 Pgm2 Psmd11 Atg7 Psmd14 Psmd13 Atp6v0a1 RT1-M10-ps5 Ddost Atp6v0c Csnk2b Psmb7 Pdxk Psmb1 Tcirg1 RT1-N3 Psmc2 Atp11b Psmc3 Cd36 Atp11a Atp6v1d Tubb4b Atp8b4 Magt1 Psmd7 Psmd6 Psmd2 Ist1 Naprt Slc2a3 RT1-M1-5 Rt1-ec3 Psmd1 Huwe1 Cyb5r3 Chrnb4 RT1-M5 Sptan1 Nras Slc27a2 Prtn3 Cfd Ubr4 Fcn2 A1bg RT1-M2 Fcn1 Np4 Cr1l Defa24 Gsn Ear1 Hp Sh3glb2 Defal1 Pglyrp1 Olr1 Defa31 Ahsg Defa Camp Ltf Tlr2 Serpina3n Lyz1 Serpinb6a Pnp Ampd3 Defa9 Anxa2 Defa8 Qsox1 Defa6 Defa3 Aprt Lcn2 Ndufc2 Lamp2 Cd177 Tnfrsf1b Mme Trpm2 Clec5a Ano6 Atp6ap2 Padi2 Mif Stom Orm1 AABR07044308.1 Cd47 Slco4c1 Cd63 Fcer1g Vcl Hsp90aa1 Dsc1 Sirpa Plau Pecam1 Clec4d Clec6a-ps1 Tyrobp Gpi Hsp90ab1 Itgav Nfasc Nckap1l Pgam1 Krt1 Prdx6 Aldoc Aldoa Pfkl Jup Cyba Pkml1 Cybb Cyfip1 Ormdl3 Hk3 Degs1 Slc15a4 Rap1a Lamtor3 Lamtor1 Rhoa Lamtor2 Ppia Fabp5 Acly Ptprc Agpat2 Mpo Cpne1 Cpne3 Slc11a1 C3ar1 Eef2 Lpcat1 Ppbp Fpr1 Cda Fpr2 C3 Galns Hexb Arsa Tollip Gsdmd Snap25 Glb1 Asah1 Gm2a Ctsg Iqgap2 Neu1 Ppie Gla Arsb Fuca2 Mmp25 Adam10 Cst3 Adam8 Mmp8 Try10 Prss2l1 Apaf1 Elane Try5 Cd44 LOC102554637 Ptafr Capn1 Timp2 Prss2 Prss3 Prss1 Cdk13 Ptpn6 Srp14 Cfp Slc44a2 Cxcr1 Cxcr2 Ftl1 Fth1 Vamp8 Alox5 Txndc5 Gusb Lta4h Rab5c Fcgr2 Fgr Fth1-ps5 C5ar1 Igf2r Acaa1b Ap1m1 Nme2 Idh1 Arg1 Hspa8 Cat Ttr Vapa P2rx1 Aoc1 Bpi Cand1 Itgax Eef1a1 Psap Frk Fuca1 Adgre5 Rab4b Hbb Cxcl1 Rap1b Hmox2 Gns Aldh3b1 Snap29 Diaph1 Cab39 Snap23 Ilf2 Hvcn1 Mapk1 Rab27a Prcp Dnajc3 Ticam2 Nfkb1 Ptges2 Rab44 Rab37 Hspa1b Hspa1a Rab3d Dsg1 Ckap4 Ctsb Ctsd Actr10 Cct2 Actr1b Ctsh Hmgb1-ps34 Ctss Cct8 Gaa Agl Pygl Mapk14 Gyg1 Npc2 Pgm1 Hmgb1l2 Hmgb1l1 Rab31 Alad Ctsa Kpnb1 Golga7 Chit1 Cd14 Pycard Rhog Dync1li1 Rac1 Armc8 Hpse Stbd1 Pld1 Dock2 Commd9 Impdh2 Rab3a Arpc5 Impdh1 Arhgap45 Commd3 Tbc1d10c Arhgap9 Trappc1 Prkcd Nbeal2 Pgrmc1 Retn Lgals3 Bin2 Serpina1 Dynlt1 Grn Dgat1 Ypel5 Aga Pygb Ear1l1 Epx Bri3 Ptprb Ghdc Mospd2 Crisp2 Rab10 Olfm4 Atad3a Fgl2 Rab14 Hgsnat Mnda Rab18 Scamp1 Cant1 Unc13d Tubb5 Rnase2 Rnase3 Vat1 Tspan14 Lrrc7 Anpep S100a9 Mlec S100a8 Stk10 Cd53 Svip Pafah1b2 ENSRNOG00000064486 Qpct Irag2 Cstb Creg1 Cd68 Cd93 ENSRNOG00000067708 Dpp7 Tarm1 Apeh Cracr2a Cpped1 Ms4a3 Pdap1 Oscar Tmem63a Vps35l Ostf1 Mmtag2 Prdx4 Plac8 Faf2 Sdcbp Ptprn2 Pa2g4 Rhof Mmp9 S100a11 Actr2 Gmfg Syngr1 Clec4a3 Clec4a2 Glipr1 Tmc6 Clec4b2 Fcgr3a Enpp4 Nfam1 Pigr Psen1 Crispld2 Dnajc13 Lilrc2 Ncstn Adgrg3 Kcmf1 Tom1 Serpinb1a Cep290 Serpinb12 Serpinb10 Gpr84 Lamp1 Arl8a Nit2 Chi3l1 Acp3 Dnase1l1 Frmpd3 Ctsc Rnase17 Mcemp1 Tmem179b Tmem30a Prg3 Gdi2 Rock1 Prg2 Bst2 Psgb1 Rap2b Rab7a Rap2c Dync1h1 Cap1 Stk11ip ENSRNOG00000064129 Gca Dnajc5 Ctsz Erp44 Plaur Dok3 Hebp2 Ceacam1 Cotl1 Kcnab2 Ggh Cnn2 Ddx3x Clec4a Ceacam6 Mvp Cmtm6 Tnfaip6 Rab6a Ptx3 Rab5b Cgm4 Sting1 Pkp1 Rab9b Siglec5 Siglec8 Gstp1 Xrcc6 Folr2 Dsp Bst1 Xrcc5 Vnn1 Man2b1 Psg29 Cd59 Cd55 Dera Itgal Itgb2 Slc2a5 Manba Ap2a2 Lair1 Vcp Mgst1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 97%10230370 Reversible hydration of carbon dioxide Ca12 Ca14 Ca13 Car7 Ca1 Ca3 Ca2 Ca6 Ca4 Ca9 Ca5b Ca5a SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%10230088 Smooth Muscle Contraction Itga1 Tpm2 Tpm1 Calm3 Mylk Tln1 Vcl Rlc-a Tpm4 Myl12b Myl7 Myl11 Myl9 Sorbs3 Myl10 Gucy1b1 Gucy1b2 Pde5a Gucy1a1 Pak1 Gucy1a2 Cald1 Lmod1 Pxn Pak2 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 97%10231088 Cargo concentration in the ER Lman2 Sar1b Tmed10 Tmed2 Gria1 Serpina1 Areg F8 Mcfd2 Cd59 Ctsc Folr1 Cnih1 Gosr2 Mia2 Lman1l Mia3 Sec24d Sec24c Sec24b Cnih3 Stx5 Sec24a Ctsz Cnih2 Sec23a Tgfa Preb Lman2l Col7a1 Lman1 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%10229956 ROS and RNS production in phagocytes Hvcn1 Rac2 Lpo Mpo Cyba Atp6v0b Cybb Atp6v0a4 Slc11a1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Nos3 Atp6v0d1 Nos2 Atp6v1b1 Ncf1 Atp6v0e1 Ncf2 Atp6v1g2 Atp6v1g1 Ncf4 Atp6v1f Atp6v1d Nos1 SUMOYLATION%REACTOME DATABASE ID RELEASE 97%10230720 SUMOylation Nfkbia Rad52 Nup58 Npm1 Nup37 Nup205 Pom121 Nup107 Nup188 Tpr Pias3 Nup160 Esr1 Sumo2 Brca1 Ikbke Mta1 Rae1 Ndc1 Vhl Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Suz12 Nup214 Ranbp2 Rara Nup155 Nup133 Nup210 Nup153 Rpa1 Ep300 Nr5a2 Hist1h4m Park7 Nr5a1 Hdac4 Mrtfa Nr3c2 Nr3c1 Ar Pcgf2 Trim28 Hnrnpc Thrb Thra Stag2 Stag1 Hnrnpk Smc1a Smc3 Trim27 Nr1i2 Senp1 Smc6 Smc5 Sp140 Nsmce4a Hic1 Eid3 Nsmce1 Nsmce2 Safb Zfp131 Sp3 Ddx17 Mageb10 Sp100 Hdac2 Mbd1 Cetn2 Casp8ap2 L3mbtl2 Ctbp1 Top2b Uhrf2 Top2a Daxx Hdac1 Top1 Vdr Satb2 Nr1h4 Dnmt1 Senp5 Senp5l1 Pias4 Uba2 Rwdd2b Ube2i Sae1 Senp2 Pias2 Xpc Blm Pias1 Ikbkg Sec13 Nfkb2 Ppara Birc5 Ring1 Xrcc4 Rangap1 Phc2 Rela Cdca8 Phc1 Incenp Cbx4 Satb1 Cbx2 Phc3 Tp53bp1 Sin3a Nrip1 Bmi1 Aurkb Parp1 Rnf2 Mitf Nop58 Pml Herc2 Tdg Nr1h3 Tfap2c Rnf168 Nr1h2 Sumo1 Sumo3 Rxra Nup93 Nup50 Ing2 Nup35 Pcna Pgr Nup54 Nup98 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-RNO-5655862.1 Translesion synthesis by POLK Rev1 Rpa1 Rpa2 Rps27a Rpa3 Rev3l Polk Ubb Ubc Uba52 Rfc5 Rfc3 Mad2l2 Rfc4 Pcna Rfc1 Rfc2 MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 97%10228626 MAPK family signaling cascades Spred1 Spred2 Cul3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Kl Fgf10 Flt3 Fgf3 Psmd12 Fgf22 Psmd11 Fgf7 Psmd14 Ppp2r5b Psmd13 Ppp2r5a Psmb5 Psmb4 Foxo1 Psmb7 Psmb6 Psmb1 Ppp2r5e Psmb3 Psmb2 Kbtbd7 Psma7 Fgfr3 Psmc5 Arrb1 Egf Psmc2 Psmc1 Psmc4 Psmc3 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Hgf Adrm1 Met Arrb2 Braf Ranbp9 Spta1 Ptpra Ncam1 Sptbn1 Sptb Sptbn2 Ptk2 Sptan1 Sptbn5 Brap Phb1 Sptbn4 Shoc2 Nras Grb2 Mras Fyn Kras Sos1 Hras Pdgfa Pdgfb Pde6d Mapkapk5 Fn1 Apbb1ip Fgb Fga Rap1b Fgg Itga2b Rasgrp1 Tln1 Pea15 Ptpn7 Paqr3 Erbb2 Ralgdsl1 Dusp16 Dusp10 Rasgrp4 Rasal1 ENSRNOG00000069024 Rasal2 Rasgrf1 Rasal3 Erbb3 Cdk1 Syngap1 Cdc14b Nrg2 Spred3 Rasa2 Dusp5 Nrg1 Rasa4 Nrg3 Rasa3 Dusp1 Nf1 Dab2ip Dusp9 Dusp8 Rapgef2 Rasgef1a Septin7 Mapk6 Mapk4 Mapk1 Etv4 Hbegf Rps27a Mapk3 Camk2a Ppp2cb Areg Ppp2ca Uba52 Frs2 Frs3 Ccnd3 Vcl Ret Ppp2r5d Angpt1 Shc3 Dusp4 Ubb Ubc Dusp7 Tek Dusp6 Icmt Zdhhc9 Itgb3 Bcl2l1 Shc2 Abhd17b Arl2 Abhd17a Prkcq Ppp2r1b Ppp2r1a Golga7 Hspb1 Fnta Lypla1 Fntb Abhd17c Rce1 Mapk12 ENSRNOG00000067432 Egfr Mark3 Artn Xpo1 Rac1 Gfra1 Gfra2 Map2k1 Foxo3 Gfra4 Ralgds Rap1a Kit Lamtor3 Src Dnajb1 Lamtor2 Ncoa3 Map3k11 Kitlg Pak1 Map2k2 Ptpn3 Pak2 Raf1 Jak2 Prkaca Lat Prkacb Pdgfrb Pdgfra Pspn Calm3 Gdnf Grin2d Nrtn Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Rasgrf2 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Lrrc7 Fgf8 Fgf9 Klb Fgf19 Fgfr4 Ywhab Ereg Actn2 Prkg2 Csk Fgfr1 Btc Cdc14a Nefl Ppp1cb Kalrn Cdc42ep2 Cdc42ep3 Rasa1 Grin1 Pak3 Cdc42 Csf2rb Jak3 Dlg1 Tyk2 Dlg2 Dlg3 Grin2b Dlg4 Pik3r1 Pik3r2 Il6st Tgfa Camk2g Camk2d Camk2b Irs1 Irs2 Csf2 Shc1 Il2 Il3 Il6 Ppp5c Il5 Pik3cb Il6r Pik3ca Il17rd Wdr83 Il2ra Ksr1 Cnksr2 Il2rb Araf Ppp1cc Pebp1 Rbx1 Ptpn11 Psmb6l1 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228322 Tyrosine catabolism Gstz1 Hpd Fah Hgd Tat TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%10228484 Transport of Mature mRNA derived from an Intron-Containing Transcript Srsf11 Nup58 Srrm1 Nup37 Rbm8a Nup205 Pom121 Slu7 Nup107 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Ncbp2 Nup42 Ncbp1 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Thoc2 Thoc3 Nup155 Thoc5 Nup133 Nup210 Thoc6 Nup153 Thoc7 Alyref Chtop Rnps1 Gle1 Sec13 Fyttd1 Casc3 Magohb Nxt1 Ddx39a Cdc40 Srsf1 Ddx39b Srsf9 Magoh Srsf7 Srsf5 Srsf3 Upf3b Srsf2 Sarnp Dhx38 Poldip3 U2af1 Nxf1 Eif4a3 Nxf5 U2af1l4 Nxf7 Nup93 Nup50 Nup35 Nup54 Nup98 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) Pold3 Rad50 Rbbp8 Brca2 Brca1 Rad51ap1 Polh Polk Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Mre11 Pole Eme2 Kat5 Eme1 Nbn Gen1 Dna2 Rad51c Blm Rad51b Chek1 Bard1 Top3a Rps27a Palb2 Firrm Xrcc3 Slx1b Xrcc2 Uba52 Atm Mus81 Pold1 Rmi2 Fignl1 Rmi1 Pold4 Brip1 Ubb Ubc Exo1 Rfc5 Pold2 Rfc3 Slx4 Rfc4 Wrn Pcna Rfc1 Spidr Rfc2 Rad51 INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling Stat5a Stat5b Jak3 Stat3 Il21 Stat1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-RNO-1299361.1 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-RNO-1855167.1 Synthesis of pyrophosphates in the cytosol Nudt4 Nudt3 Ip6k3 Ippk Ip6k1 Ppip5k1 Ppip5k2 Itpk1 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-RNO-9033241.1 Peroxisomal protein import Pex13 Dao Pex12 Ube2d2 Crot Acox3 Ide Hao1 Ddo Ephx2 Phyh Eci2 Mpv17 Hacl1 Gstk1 Mlycd Gnpat Agxt Acox1 Ech1 Ehhadh Acaa1b Tysnd1 Lonp2 Hao2 Pecr Idh1 Ube2d3 Decr2 Nudt19 Ube2d1 Acot1 Acot2 Pex1 Acot5 Acot3 Usp9x Acot4 Rps27a Pex7 Pex6 Pex5 Cat Zfand6 Agps Nudt7 Hmgcl Pex10 Uba52 Amacr Hsd17b4 Dhrs4 Baat Scp2 Crat Acox2 Acot8 Slc27a2 Ubb Nos2 Ubc Pipox Pex2 Pex26 Pex14 RELAXIN RECEPTORS%REACTOME%R-RNO-444821.1 Relaxin receptors Rxfp3 Rxfp1 Insl3 Rln3 Rln1 SIGNALING BY PDGF%REACTOME%R-RNO-186797.1 Signaling by PDGF Nck2 Bcar1 Thbs1 Rapgef1 Stat3 Pdgfrb Stat1 Pdgfra Stat5a Plg Stat5b Rasa1 Stat6 Spp1 Furin Grb7 Plcg1 Pik3cb Plat Col4a1 Col4a2 Pik3ca Src Pik3r1 Pik3r2 Nras Grb2 Pdgfc Kras Pdgfd Sos1 Crk Hras Pdgfa Pdgfb Ptpn11 Thbs2 Thbs4 Nck1 Ptpn12 Crkl EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-RNO-9818564.1 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Tbl1x Rb1 H2ac18 Ajuba Crebbp Sirt1 Hdac3 Hist1h2bq Tbl1xr1 Ncoa2 Med23 Med24 Med20 Ncor2 Paxip1 Med27 H2aj Ep300 Med12 Gps2 Med1 H3-3b Med13 Med14 Hist3h2ba Ncoa3 Med10 Med4 Pparg Med6 H2bc18 Med16 Med17 H2az2 Ccnc H2bc6 H2bc4 Pagr1 Hist1h4m H2bc1 Med30 Abl1 Med31 Ppargc1a Ppargc1b Hist1h2ai Cdk5 H2ab2 H2ac4 Rxra SIGNALING BY ALK%REACTOME%R-RNO-201556.1 Signaling by ALK Plcg1 Ptn Alkal2 Alkal1 Jak3 Pik3cb Hdac2 Pik3ca Stat3 Ptprz1 Hdac1 Ep300 Pik3r1 Irs1 Pik3r2 Alk Hdac3 Ptpn6 Mdk Shc1 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%10229244 GAB1 signalosome Hbegf Btc Pik3ca Src Egfr Pik3r1 Ereg Egf Grb2 Tgfa Csk Areg Gab1 Ptpn11 Pxn Pag1 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Tirap Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 97%10228564 Beta oxidation of myristoyl-CoA to lauroyl-CoA Hadha Hadhb Acadl TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-RNO-5656169.1 Termination of translesion DNA synthesis Pold3 Rev1 Rps27a Poli Polh Polk Ube2l6 Pole3 Pole2 Uba52 Pole4 Trim25 Isg15 Pclaf Rpa1 Rpa2 Usp43 Pold1 Rpa3 Pold4 Pole Ubb Ubc Usp10 Rfc5 Uba7 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 DISINHIBITION OF SNARE FORMATION%REACTOME%R-RNO-114516.1 Disinhibition of SNARE formation Prkcb Stx4 Prkcg Stxbp3 Prkca APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 97%10229180 APC C:Cdc20 mediated degradation of mitotic proteins Pttg1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ccnb1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Cdk1 Nek2l1 Psmd7 Psmd6 Psmd8 Ube2d1 Psmd2 Rps27a Psmd1 Adrm1 Uba52 Ube2s Cdc20 Ube2c Cdc27 Ccna1 Cdc26 Ccna2 Cdc23 Mad2l1 Anapc10 Anapc16 Anapc15 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ubb Ubc Psmb6l1 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-RNO-6807047.1 Cholesterol biosynthesis via desmosterol (Bloch pathway) Ebp Sc5d Cyp51a1 Nsdhl Dhcr24 Dhcr7 Tm7sf2 Hsd17b7 Lbr Msmo1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins St3gal4 St3gal2 Muc19 B3gnt9 B3gnt8 St3gal3 B3gnt6 Muc15 Galnt5 St3gal1 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 B3gnt3 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Gcnt1 C1galt1 C1galt1c1 Galntl6 Galntl5 Galnt3 A4gnt Muc5b Muc4 Muc6 Galnt1 Galnt9 Galnt2 St6galnac3 Muc13 St6galnac2 B3gnt5 Qtgal B3gnt7 B3gnt2 St6gal1 B4galt5 B4galt6 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%10230130 Interleukin-2 family signaling Il9r Jak2 Stat3 Stat1 Stat5a Stat5b Csf2 Inpp5d Shc1 Il15 Il2 Il3 Il5 Csf2rb Il9 Jak3 Pik3cb Pik3cd Syk Gab2 Pik3ca Il2ra Pik3r1 Il2rb Pik3r2 Il15ra Pik3r3 Grb2 Sos2 Sos1 Ptpn6 Inppl1 Il21 Lck Ptk2b SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression H2bc6 H2bc4 Hist1h4m H2bc1 H2ac18 Suv39h1 Rrp8 H2aj Hist1h2ai H2ab2 H3-3b Hist3h2ba Sirt1 H2ac4 H2bc18 Hist1h2bq H2az2 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229614 Catecholamine biosynthesis Dbh Ddc Th Pnmt NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway Mapk1 Raf1 Map2k2 Braf Mapk3 Map2k1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 97%10228750 Activation of caspases through apoptosome-mediated cleavage Cycsl2 Casp9 Apaf1 Xiap Casp7 Cycs Casp3 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 97%10228416 Caspase activation via extrinsic apoptotic signalling pathway Tlr4 Ticam2 Cd14 Traf2 Ticam1 Casp9 Fadd Dcc Ripk1 Casp8 Appl1 Tradd Ly96 Fas Casp3 Cflar Faslg Tnfsf10 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231188 ERBB2 Activates PTK6 Signaling Erbb2 Ereg Egf Hbegf Erbb3 Btc Nrg2 Nrg1 Nrg3 Ptk6 Egfr RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-RNO-75953.1 RNA Polymerase II Transcription Initiation Gtf2h5 Tbp Ercc2 Ccnh Ercc3 Taf4b Taf7l-ps1 Gtf2a1 Cdk7 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Taf4 Gtf2e1 Taf2 Taf1 Gtf2e2 Polr2c Polr2a Taf9 Polr2b Polr2g Polr2h Polr2e Polr2f Mnat1 Polr2i Taf9b Polr2j Taf15 Taf11 Taf10 Taf13 Taf12 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 97%10228686 Signaling by GPCR Pde3b Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 S1pr4 Lpar3 Lpar1 Prkch Nras Grb2 Kras Sos1 Hras Mgll Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Daglb Dagla Ffar4 Ghrl Abhd12 Rgs7 Pdpk1 Mmp3 Src Rhoa Ngef Prkce Mcf2l Pik3r5 Tiam2 Plxnb1 Pik3r6 Arhgef15 Pik3cg Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Adora2b Fgd4 Adora2a Arhgef37 Abr Ednrb Fgd3 Ednra Sct Arhgef39 Arhgef38 Npff Arhgef33 Rrh Ptgdr Ect2 Htr4 Prex1 Trio Apln Trhr Mcf2 Tas2r39 Htr6 Plekhg5 Plekhg2 Oprd1 Htr7 Net1 Rasgrf2 Tas2r38 C3ar1 Arhgef10l Crhbp Galr2 Galr3 Galr1 Cmklr1 Sstr5 Sstr4 Sstr3 Kel Sstr2 Pde10a Sstr1 Avpr1b Pde11a Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Pde2a Lhb Ppbp Fpr1 Itpr1 Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Rgsl1 Vipr2 Ghsr Nln Rgs4 Vipr1 Rgs5 C5 Rgs2 Rgs20 Ptgfr Rgs3 Rgs17 Pnoc Rgs1 Rgs16 Tas2r16 Rgs8 Gnaz Tas2r13 Pcp2 Ppy Gpsm3 Tas2r135 Gpsm2 Cga Gpsm1 Tas2r136 Gna12 Nmb Rgs21 Oxtr Rgs18 Lpar6 Rgs19 Xcr1 Rgs13 Gpr18 Rgs14 Grpr Rgs12 Gpr17 Ccr1l1 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Brs3 Ptger4 Tas2r7 Gabbr1 Ptger2 Vav1 Ptger3 Fshr Gabbr2 Pik3r1 Ptger1 Pik3r2 Pik3r3 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Crhr1 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr2 Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Taar5 Rgr Taar1 Hcrt Npb Gpr143 Grp Opn1mw Pth Kiss1r Shc1 Gcgr Sctr Ccl19 Ccl17 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npffr1 Npy Npffr2 Ghrh Ptgdr2 Rho Pik3ca Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Qrfprl Gpr4 Sos2 Gcg Ptgdrl Qrfp Ccl27 Agt Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Mc3r P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Rhoc Tas2r40 Rhob Fpr2l1 Tas2r41 Hcar1 Adra2a Prokr2 Adra2c Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Btk Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Calcr Cxcl12 Casr Cxcl10 C5ar2 C5ar1 Ffar3 Arrb1 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Calcb Chrm1 Calca Hrh1 Chrm3 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Trpc7 Ccrl2 Gper1 Oxgr1 Opn5 Sucnr1 Trpc3 Itpr3 Pyy Itpr2 Adora1 Adora3 Rln3 Ltb4r2 F2r Rln1 Arrb2 Cxcl16 F2 Cxcl13 F2rl2 Ucn F2rl3 Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Qrfpr Insl3 Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Akt3 P2ry2 Ccl5 Akt2 P2ry1 Ccl4 Ccl3 Akt1 Gast Hcrtr2 Hcrtr1 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Itsn1 Tas2r107 Gpr37l1 Ackr3 Ackr4 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb App Mapk7 Mapk1 Hbegf Mapk3 Agtr1 Ppp2cb Gnat2 Ppp2ca Rps6ka3 Rps6ka1 Rps6ka2 Ppp2r5d Prkcq Ppp2r1b Ppp2r1a Egfr Chrm2 Vav3 Vav2 Plcb4 Plcb3 Pla2g4a Pdyn Plcb2 Pak1 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Itgb1 Gnaq Gng7 Pde4d Gng8 Gngt1 Gnat3 Prkar2a Cdk5 Pde1b Pde1c Gnb2 Pde1a Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Rgs9 Gnat1 Tiam1 Avpr2 Kalrn Arhgef7 Cdc42 Rock2 Rock1 Avp Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Cd55 Adrb2 Tacr1 Grk3 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231266 Regulation of RUNX3 expression and activity Psmd8 Psmd2 Smurf2 Smurf1 Rps27a Psmd1 Tgfb1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Runx3 Psma1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ep300 Src Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Cbfb Psmd7 Psmd6 Psmb6l1 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%10230932 Cargo trafficking to the periciliary membrane Cnga4 Rab3ip Pkd1 Cnga2 Asap1 Smo Gbf1 Rab11a Rab8a Unc119b Atat1 Arl3 Nphp3 Rho Cct3 Rp2 Bbs2 Cct2 Sstr3 Bbs10 Mkks Bbs12 Arl6 Cngb1 Ttc8 Exoc3 Tcp1 Exoc4 Lztfl1 Mchr1 Bbip1 Exoc5 Bbs7 Exoc6 Cct8 Bbs5 Exoc1 Inpp5e Bbs4 Exoc2 Arl13b Cct5 Cct4 Pde6d Arf4 Exoc7 Exoc8 Thoc2l RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-RNO-110314.1 Recognition of DNA damage by PCNA-containing replication complex Pold3 Rps27a Pole3 Pole2 Uba52 Ube2b Pole4 Wdr48 Rpa1 Rpa2 Ddb1 Usp1 Cul4a Pold1 Rpa3 Dtl Pold4 Cul4b Pole Ubb Ubc Rad18 Rbx1 Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling Pde3b SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181429.1 Serotonin Neurotransmitter Release Cycle Syt1 Vamp2 Stxbp1 Slc18a2 Syn3 Syn2 Syn1 Unc13b Cplx1 Rims1 Stx1a Rab3a Ppfia3 Snap25 Tspoap1 Ppfia2 Ppfia4 Ppfia1 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin Fdxr Fdx2 Fdx1 SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions Itgb3 Fgf2 Sdc4 Sdc3 Itga6 Tgfb1 Prkca Vtn Itga2 Itgb4 Sdc1 Sdc2 Itgav Itgb1 B CELL ACTIVATION%REACTOME%R-RNO-983705.1 B Cell Activation Nfkbia Cd22 Cul1 Psma4 Psma3 Psma6 ENSRNOG00000069193 Chuk AABR07065813.1 Psma5 ENSRNOG00000062915 Psma2 Igll1 Psma1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Dapp1 ENSRNOG00000070415 Nfatc3 Psmd12 ENSRNOG00000070810 Nfatc2 ENSRNOG00000066926 Psmd11 ENSRNOG00000066406 Psmd14 ENSRNOG00000067897 Blnk ENSRNOG00000062685 Psmd13 ENSRNOG00000070192 Psmb5 Iglc1 Plcg2 Psmb4 ENSRNOG00000070159 ENSRNOG00000071049 Psmb7 Btk Psmb6 AABR07034736.1 Psmb1 ENSRNOG00000065564 Psmb3 ENSRNOG00000066971 Psmb2 ENSRNOG00000063341 ENSRNOG00000065283 Lyn ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Psma7 Igkvl13 Psmc5 Fkbp1a AABR07065812.2 Psmc2 ENSRNOG00000063707 ENSRNOG00000067679 Psmc1 Psmc4 ENSRNOG00000070832 Psmc3 ENSRNOG00000064085 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 Psmd7 Psmd6 Psmd8 ENSRNOG00000064490 ENSRNOG00000066072 Sh3kbp1 Psmd2 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Psmd1 Adrm1 Itpr3 Itpr2 Calm3 Nras Grb2 Kras Sos1 Hras Itpr1 Cd19 Rasgrp1 Syk Vav1 Trpc1 Pik3r1 Prkcb Ikbkb Ikbkg Ppp3ca Rps27a Ppp3cb Bcl10 Pik3ap1 Nfkbie Nfkb1 Nfatc1 Ppp3r1 Skp1 Rel Uba52 Fbxw11 Rela Malt1 Btrc Pik3cd Stim1 Ubb Ubc Cd79a Nfkbib Ptpn6 Cd79b Nck1 Psmb6l1 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%10231546 Cellular response to starvation Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Atp6v0c Lamtor5 Rptor Lamtor3 Atp6v1e2 Rraga Atp6v1e1 Lamtor4 Tcirg1 RragB Atp6v1a Lamtor1 Atp6v1b2 Atp6v0d2 Rragc Lamtor2 Atp6v0d1 Atp6v1b1 Rragd Atp6v0e1 Atp6v1g2 Mtor Atp6v1g1 Atp6v1f Rheb Atp6v1d Mlst8 Slc38a9 Sec13 Mios Depdc5 Fnip1 Fnip2 Samtor Szt2 Castor2 Castor1 Sesn2 Sesn1 Kics2 Itfg2 Wdr24 Nprl3 Nprl2 Flcn Wdr59 Sh3bp4 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-RNO-212165.1 Epigenetic regulation of gene expression Zfp950l5 Tbp Tbl1x Kmt2a Kmt2c Taf1d H2ac18 Taf1a Ezh2 Taf1c Taf1b Ajuba Crebbp Polr1b Polr1c Polr1a Polr1f Polr1g Zfp52 Polr1e Hdac3 Polr1h Mybbp1a Suz12 Znf354a Hist1h2bq Tbl1xr1 Tasor Wdr5 Morc2 Ash2l Setdb1 Atf7ip LOC102546572 Pphln1 Eed Ncor2 Gsk3b H2aj Myo1c Ep300 Gps2 H3-3b Hist3h2ba Ncoa3 Kat2b Znf382 H2bc18 H2az2 Ccnc Ezhip H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Suv39h1 Kat2a Hist1h2ai Zfp317 Aebp2 Ercc6 Cdk5 Trim28 Dek Zfp324 LOC120095871 Dnmt3a Zfp719 Mphosph8 ENSRNOG00000070049 Rb1 Ezh1 Zfp758 Sf3b1 Sirt1 Mbd2 Zfp964 Men1 Actg1 Ncoa2 Jarid2 Med23 Med24 Med20 Tasp1 Dnmt1 Akap8l Phf20 Cxxc1 Kat8 Paxip1 Med27 Med12 Med1 Yeats2 Med13 Med14 Wdr82 Med10 Med4 Pparg Med6 Kat14 Mbip Hcfc1 Med16 Med17 Hcfc2 Zfp808l3 Dr1 Baz1b Kansl3 Kansl1 Kansl2 Phf20l1 Setd1b Bod1l1 Setd1a Pagr1 Tada3 Med30 Abl1 Tada2a Med31 Ppargc1a Ppargc1b Kmt2d Mcrs1 Zzz3 Kmt2b Sgf29 Psip1 Ogt Znf431l2 ENSRNOG00000065205 Cbx5 Znf624l Phf19 Rrp8 H2ab2 Polr2h Smarca5 Polr2e Polr2f Tdg H2ac4 Ddx21 Epop Rxra Rex2l4 Zfp867 Mtf2 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-RNO-9839397.1 TGFBR3 regulates FGF2 signaling Fgf2 Tgfbr3 Gipc1 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-RNO-418038.1 Nucleotide-like (purinergic) receptors P2ry13 P2ry12 P2ry14 P2ry6 P2ry4 P2ry2 P2ry1 Lpar4 Lpar6 Adora1 Adora2b Adora3 Adora2a Gpr17 P2ry10 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%10228406 Resolution of AP sites via the single-nucleotide replacement pathway Polb Apex1 Xrcc1 Lig3 SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling Irs2 Grb2 Sos1 Irs1 GLYCOLYSIS%REACTOME%R-RNO-70171.1 Glycolysis Pgam2 Pgam1 Tpi1 Nup58 Nup37 Nup205 Hkdc1 Pom121 Gckr Nup107 Pklr Nup188 Gapdhs Aldoc Tpr Bpgm Nup160 Aldoa Pfkl Pgk1 Rae1 Ndc1 Pgk2 Nup85 Pfkm Pfkp Nup42 Pgm2l1 Nup62 Nup43 Pkml1 Nup88 Gck Aaas Hk2 Hk3 Nup214 Adpgk Ranbp2 Tpi1l2 Nup155 Nup133 Nup210 Nup153 Sec13 Aldob Gnpda1 Gpi Gnpda2 Eno3 Nup93 Eno2 Nup50 Eno4 Pfkfb4 Pfkfb3 Nup35 Pfkfb2 Pfkfb1 Nup54 Nup98 BASE EXCISION REPAIR%REACTOME%R-RNO-73884.1 Base Excision Repair Pold3 H2ac18 Pole3 Pole2 Pole4 Hist1h2bq Terf2 Terf1 Tinf2 Rpa1 Rpa2 Acd Terf2ip Rpa3 Pot1 H2aj Pole Hist3h2ba Lig3 Neil2 Neil1 Pnkp H2az2 H2bc6 Neil3 H2bc4 Hist1h4m H2bc1 Hist1h2ai Xrcc1 Fen1 Lig1 Polb Parg Parp2 Pold1 Apex1 Parp1 Adprs Pold4 Mbd4 H2ab2 Smug1 Mpg Tdg Nthl1 Ogg1 H2ac4 Ung Mutyh Rfc5 Pold2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes Tbl1x Ccnd1 Cdk4 Kdm1b Kmt2a Prmt5 Kmt2c H2ac18 Ezh2 Pbrm1 Mta1 Smarcd1 Mta2 Smarcb1 Mta3 Smarcd3 Mbd3 Brpf1 Smarcd2 Kat6a Hdac3 Chd3 Arid1a Suz12 Arid1b Gatad2a Hist1h2bq Prmt1 Gatad2b Tbl1xr1 Wdr5 Ash2l Actl6a Setdb1 Atf7ip Smarce1 Wdr77 Smarcc1 Smarca2 Eed Ncor2 Carm1 Gps2 Hist3h2ba H2bc18 Sap30l Suds3 Brms1 Rest Arid4b Arid4a H2bc6 Rbbp5 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Suv39h1 Suv39h2 Smyd2 Smyd3 Hist1h2ai Setd3 Nsd3 Setd2 Setd7 Kmt5c Setdb2 Hdac10 Setd6 Nsd1 Aebp2 Hdac8 Mecom Prdm16 Kmt5b Prdm9 Dot1l Ash1l Ehmt1 Kdm4c Coprs H2ac25 Prmt6 Prmt7 Dnmt3a Prmt3 Actl6b Chd4 Hdac2 Hdac1 Kmt5a Kdm1a Ncoa2 Brpf3 Phf20 Kat8 Phf2 Riox2 Kdm2b Hcfc1 Kdm4d Kdm3b Kdm5c Atf2 Kdm3a Kdm5b Phf8 Kansl3 Kdm5a Kansl1 Padi2 Rcor1 Kdm6b Kansl2 Padi3 Kdm6a Padi4 Kdm7a Setd1b Padi1 Arid5b Kat7 Setd1a Uty Padi6 Jmjd6 Ing4 Pax3 Hat1 Jade1 Jade2 Jade3 Kat6b Kmt2d Nfkb2 Msl2 Mcrs1 Nfkb1 Msl3 Kmt2b Msl1 Ogt Brwd1 Rela Rps2 Kdm4b Kdm4a Meaf6 Sap18 Hmg20b H2ac4 Smarca4 Ing5 Brd1 Nsd2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228160 Lagging Strand Synthesis Pold3 Rpa1 Fen1 Rpa2 Lig1 Prim2 Pold1 Rpa3 Prim1 Pold4 Pola2 Rfc5 Pola1 Pold2 Rfc3 Dna2 Rfc4 Pcna Rfc1 Rfc2 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%10231116 rRNA processing Rpl4 Rps14 Rps15 Rpl5 Rps16 Rpl3 Rps17 Csnk1d Rps18 Rps19 Las1l Ltv1 Rpl35 Fcf1 Rpl36 Rpsa Rpl37 Rpl38 Rps10 Rpl39 Rpl8 Rps11 Rpl9 Rrp9 Rpl6 Rps13 Pwp2 Rpl7 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rps9 Rps7 Rps8 Rps5 Rps6 Rpl24 Rpl26 Imp4 Rpl27 Rpl28 Rpp25 Rpl29 Rpl12-ps1 Ncl Rpl22 Xrn2 Rpl23 Snu13 Wdr75 Senp3 Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Rps25 Rps26 Rps27 Rps28 Rps29 Pdcd11 Pno1 Rpl27a Rpl31l15 Rps20 Utp20 Rps21 Nop14 Rps23 Pelp1 Rps24 Rcl1 Utp25 Tbl3 Nol11 Rpp40 LOC100910714 Rps15a LOC102551819 Wdr3 Bud23 Dcaf13 Rps4x-ps13 Utp15 LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Rps3a Utp18 Wdr43 Rps27l Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Ddx49 Rpl35al8 Rps26-ps13 Wdr36 Rpl22l1 Ddx47 Rplp0 Rplp1 Rpl13a Rpl35al2 Csnk1e Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Nol9 Mphosph6 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Uba52 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rps3 Rps2 Rpl10a Exosc9 Rps4x Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Wdr18 Tsr1 Ubc Ddx21 Fau Rpl23a Wdr12 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%10228162 DNA strand elongation Pold3 Rpa1 Fen1 Rpa2 Lig1 Prim2 Pold1 Rpa3 Prim1 Pold4 Gins2 Gins1 Gins4 Gins3 Pola2 Rfc5 Pola1 Pold2 Rfc3 Dna2 Rfc4 Pcna Rfc1 Rfc2 HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state Kif3a Smo Csnk1a1 Cul1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Adcy3 Adcy4 Adcy1 Itch Adcy2 Psmd7 Adcy7 Psmd6 Adcy8 Psmd8 Psmd2 Adcy5 Adcy6 Adcy9 Prkaca Rps27a Prkacb Psmd1 Adrm1 Gpr161 Prkar1a Skp1 Rpgrip1l Prkar1b Tulp3 Uba52 Adcy10 Ift140 Ptch1 Fuz Mks1 Ift52 Prkar2a Ttc21b Gli1 Ift57 Btrc Gli3 Gli2 Numb Ift122 Ofd1 Intu Kif7 Wdr35 Dync2h1 Ubb Ubc Ift172 Rbx1 Wdr19 Sufu Psmb6l1 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%10230728 Initiation of Nuclear Envelope (NE) Reformation Sirt2 Kpnb1 Ppp2r1a Lmna Emd Ccnb2 Lmnb1 Ccnb1 Vrk1 Ankle2 Vrk2 Ppp2ca Banf1 Cdk1 Ppp2r2a Ccnb2-ps2 Lbr INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME%R-RNO-9940951.1 Interaction of NuRD complexes with transcription factors H2bc6 Rbbp4 Zfp592 H2bc4 Hist1h4m H2bc1 Cdk2ap1 Rbbp7 Chd4 Hdac2 Nr2f2 Zmynd8 H2ac18 Ikzf3 Hdac1 Ikzf1 Chd5 Hist1h2ai Mta1 Mta2 Zfp827 Tcf19 Mta3 Zfp532 Mbd3 Mbd2 Nr2c2 Chd3 Hist1h2bq Gatad2a Gatad2b Phf6 H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2bc18 H2az2 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Skp1 Ppp2cb Ppp2ca Uba52 Tirap Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Btrc Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle Lin7b Lin7c Apba1 Syt1 Vamp2 Stxbp1 Slc18a2 Syn3 Syn2 Syn1 Unc13b Cplx1 Rims1 Stx1a Rab3a Ppfia3 Snap25 Tspoap1 Ppfia2 Ppfia4 Cask Ppfia1 Lin7a SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229754 Semaphorin interactions Rhoc Rhob Sema7a Plxna1 Rac1 Tln1 Pak3 Rnd1 Rock2 Rras Rock1 Gsk3b Rhoa Dpysl2 Limk1 Erbb2 Dpysl3 Dpysl4 Dpysl5 Pak1 Ptprc Cd72 Plxnb1 Pak2 Plxnb3 Plxna4 Arhgef11 Plxna3 Arhgef12 Plxna2 Met Arhgap35 Crmp1 Plxnc1 Fes Sema6d Plxnd1 Cdk5r1 Cdk5 Sema5a Hsp90aa1 Sema4d Sema4a Trem2 Nrp1 Tyrobp Fyn Hsp90ab1 Sema3a Sema3e Pip5k1c Farp2 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230438 Collagen degradation Col26a1 Mmp12 Mmp13 Mmp14 Mmp2 Mmp9 Mmp15 Mmp8 Mmp10 Col15a1 Col13a1 Col19a1 Phykpl Furin Try5 Mmp7 Mmp3 Col25a1 Ctsb Ctsd Prss3 Tmprss6 Ctsk Mmp1b Ctsl Col18a1 Mmp20 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%10229626 Platelet sensitization by LDL Ppp2r1b Ppp2r1a Ppp2r5e Lrp8 Pecam1 Ppp2r5d Fgr Pla2g4a Ppp2cb Ppp2ca Ptpn6 Mapk14 Ptpn11 Apob Ppp2r5b Ppp2r5a EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%10229280 EGFR downregulation Spry2 Sh3kbp1 Spry1 Hbegf Btc Rps27a Eps15 Sh3gl1 Egfr Stam Stam2 Arhgef7 Areg Uba52 Epn1 Cdc42 Sh3gl2 Ereg Egf Ubb Grb2 Ubc Tgfa Eps15l1 Hgs Cbl Sh3gl3 Ptpn3 Ptpn12 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%10230222 Regulation of signaling by CBL Pik3cb Syk Rapgef1 Pik3cd Pik3ca Vav1 Lyn Hck Yes1 Pik3r1 Pik3r2 Pik3r3 Grb2 Fyn Crk Cbl Crkl MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Irf3 Ube2d2 Tab2 Usp18 Tab1 Nlrc5 Cd14 Ikbke Chuk Mapk10 Mapk11 Ube2d3 Ube2d1 Tank Traf3 Sarm1 Ripk3 Fadd Ripk1 Tbk1 Optn Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Nfkb1 Traf2 Ticam1 Skp1 Birc2 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Rps6ka5 Rps6ka1 Tifa Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Nod2 Nod1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ubb Ripk2 Ubc N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Ptpn11 Mapk14 Jun Mapkapk2 Irak2 Irak1 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9033807.1 ABO blood group biosynthesis Fut2 Fut1 Abo2 DEATH RECEPTOR SIGNALING%REACTOME%R-RNO-73887.1 Death Receptor Signaling Nfkbia Tab3 Ube2d2 Tab2 Tab1 Ikbke Chuk Ywhae Rac1 Vav3 Vav2 Arhgdia Adam17 Omg Mag Prkci Ngfr Rhoa Ngef Bex3 Rtn4 Itgb3bp Casp2 Rbck1 Mcf2l Tiam2 Ube2d3 Bcl2l11 Arhgef15 Ube2d1 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Akap13 Arhgef26 Arhgef25 Mib2 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Fadd Arhgef37 Abr Ripk1 Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Mcf2 Plekhg5 Plekhg2 Net1 Rasgrf2 Arhgef10l Sos1 Tiam1 Tbk1 Ulk1 Psenen Smpd2 Smpd3 Psen1 Psen2 Kalrn Ncstn Aph1a Optn Arhgef7 Aph1b Ngf Itsn1 Otulin Clip3 Sppl2b Sppl2a Vav1 Tnfrsf1a Sharpin Tnf Ikbkb Usp21 Otud1 Traf1 Mapk8 Spata2 Traf6 Rnf31 Usp2 Usp4 Ikbkg Rack1 Cyld Otud7b Rps27a Map3k7 Ube2l3 Nfkb1 Traf2 Sqstm1 Birc2 Uba52 Xiap Rela Stub1 Tax1bp1 Myd88 Ubb Nsmaf Ripk2 Ubc Sos2 Casp8 Tradd Fas Madd Cflar Mapkapk2 Casp3 Faslg Irak1 Tnfsf10 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-RNO-168898.1 Toll-like Receptor Cascades Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Ppp2r1b Ppp2r1a Usp14 Cul1 Tab3 Irf3 Ube2d2 Tab2 Usp18 Tab1 Nlrc5 Cd14 Ikbke Chuk Mapk10 Mapk11 Tasl Dnm1 Irf5 Slc15a4 Pik3c3 Dnm3 Plcg2 Dnm2 Pik3r4 Cd36 Ube2d3 Ube2d1 Cd180 Tank Ly86 Traf3 Sarm1 Ripk3 Lbp Bpi Fadd Ripk1 Tirap Ptpn4 S100a9 S100a8 Tlr6 Unc93b1 Lgmn Tlr9 Tlr8 Tlr7 Cnpy3 Tbk1 Rbsn Tlr1 Tlr2 Gsdmd Fgb Optn Fga Fgg S100a1 Apob Tlr10 Hsp90b1 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Mapk1 Peli1 Ikbkg Map3k8 Rps27a Map3k7 Mapk3 Ube2n Ticam2 Lrrc14 Nfkb2 Gsdme Nfkb1 Traf2 Ticam1 Ecsit Skp1 Birc2 Ppp2cb Ppp2ca Uba52 Fbxw11 Fos Vrk3 Alpk1 Rela Ly96 Rps6ka3 Map3k1 Rps6ka5 Peli2 Rps6ka1 Tifa Peli3 Rps6ka2 Irf7 Btrc Tlr4 Tnip2 Ctsb Nod2 Nod1 Eea1 Ppp2r5d S100b Map2k7 Map2k6 Dusp3 Dusp4 Hmgb1-ps34 Ctsk Ubb Ctsl Ripk2 Ubc Ctss N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Ptpn11 Mapk14 Jun Mapkapk2 Irak2 Irak1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors Chrnb2 Chrne Chrng Chrna4 Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrnb3 Chrna9 Chrnb4 Chrna3 Chrnd SIGNALING BY SCF-KIT%REACTOME%R-RNO-1433557.1 Signaling by SCF-KIT Chek1 Tec Mmp9 Fer Jak2 Stat3 Stat1 Prkca Stat5a Stat5b Fes Grb10 Rac1 Cma1 Grb7 Kit Gab2 Pik3ca Vav1 Lyn Yes1 Src Pik3r1 Pik3r2 Pik3r3 Nras Grb2 Fyn Kras Kitlg Sos1 Hras Ptpn6 Cbl Ptpn11 Sh2b2 Lck Grap Ptpru Grap2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 Gng8 Gngt1 P2ry12 Gnat3 Gnb2 Gnb1 Gnb4 Gnb3 Gnai2 Gnb5 Gnai1 Gng11 Gng12 Gnai3 Gng3 Gng10-ps1 Gng5 Gng4 Gng7 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-RNO-2022377.1 Metabolism of Angiotensinogen to Angiotensins Atp6ap2 Gzmf Ace Ctsd Ctsz Ces1d Cpb1 Cpb2 Cpa3 Mme Agt Ctsg Ren1 Ace2 Enpep Cma1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-RNO-5654696.1 Downstream signaling of activated FGFR2 Gab1 Fgf10 Frs2 Fgf3 Frs3 Fgf22 Shc1 Fgf7 Fgf16 Fgf17 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Pik3ca Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling Il7 Jak3 Tslp Stat3 Pik3r1 Irs1 Pik3r2 Irs2 Pik3r3 Stat5a Smarca4 Stat5b Il7r Brwd1 H2bc18 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230724 Nuclear Pore Complex (NPC) Disassembly Nup58 Nup37 Nup205 Pom121 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Nup214 Ranbp2 Nup155 Nup133 Nup210 Nup153 Ccnb2 Ccnb1 Cdk1 Ccnb2-ps2 Nup93 Nup50 Nup35 Nup54 Nup98 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10230960 RHO GTPases regulate CFTR trafficking Cftr Rhoq Gopc MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 97%10230076 Miscellaneous transport and binding events Nipal1 Add1 Slc66a1 Add2 Nipa1 Nipa2 Azgp1 Lrrc8e Tusc3 Lrrc8a Lrrc8b Lrrc8c Lrrc8d Ankh Pip Ctns Rhag Rhcg Rhbg Add3 Mrs2 Nipal4 Magt1 Dmtn Nipal2 Nipal3 FREE FATTY ACID RECEPTORS%REACTOME%R-RNO-444209.1 Free fatty acid receptors Ffar3 Ffar1 Ffar2 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-RNO-5218921.1 VEGFR2 mediated cell proliferation Plcg1 Vegfa Sphk1 Prkcd Prkcz Src Prkca Nras Prkcb Kras Rasa1 Hras Pdpk1 Kdr FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation Fgf18 Fgfr3 Fgf20 Fgf1 Fgf8 Fgf9 Fgf17 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-RNO-5686938.1 Regulation of TLR by endogenous ligand Hmgb1l2 Tlr1 Hmgb1l1 Tlr4 S100a9 Tlr6 S100a8 Tlr2 Gsdme Cd14 Hmgb1-ps34 Gsdmd Tlr7 Fgb Lbp Fga Cd36 Fgg S100a1 Ly96 Apob INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%10228860 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Anapc16 Ube2d1 Anapc15 Anapc5 Bub1b Anapc4 Anapc1 Anapc2 Anapc7 Ube2e1 Cdc16 Ube2s Cdc20 Ube2c Cdc27 Cdc26 Mad2l1 Cdc23 Anapc10 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-RNO-380972.1 Energy dependent regulation of mTOR by LKB1-AMPK Prkag1 Prkag2 Prkab2 Prkab1 Stk11 Lamtor5 Rptor Lamtor3 Rraga Lamtor4 RragB Lamtor1 Tsc2 Rragc Tsc1 Prkaa1 Lamtor2 Rragd Mtor Cab39 Rheb Ppm1a Stradb Mlst8 Slc38a9 Strada Prkag3 Cab39l GLYCOPROTEIN HORMONES%REACTOME%R-RNO-209822.1 Glycoprotein hormones Inhbc Inhba Inha Inhbe Lhb Tshb Fshb Cga Inhbb TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 97%10229700 trans-Golgi Network Vesicle Budding Clvs1 Ap1g2 Ap4m1 Clvs2 Picalm ENSRNOG00000062839 Tbc1d8b Dnajc6 Arf1 Ocrl Ftl1 Ap3b1 Fth1 Clta Ap1b1 Cltc Sh3d19 Napa Necap1 Vamp8 Golgb1 Ap1s3 Ap1s2 Txndc5 Ap1g1 Tpd52l1 Dnm2 Ap4s1 Rab5c Gns Vamp7 Gak Tpd52 Ap4e1 Hip1r Vamp2 Dtnbp1 Sh3gl2 Yipf6 M6pr Snapin Snx2 Ctsz Ap4b1 Fth1-ps5 Arrb1 Snx9 Ttgn1 Igf2r Snx5 Ap1m2 Bloc1s1 Stx4 Ap1m1 Dnase2 Bloc1s3 Bloc1s4 Snap23 App Tfrc Bloc1s6 Pik3c2a Acbd3 Pum1 Hspa8 Sort1 Cpd Cltb Gbf1 Hgs Chmp2a KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization Krtap2-4l1 Krtap3-1 Krt4 Krt2 Krtap3-2 Krt1 Krt8 Krt7 Krt5 Krt9 LOC680428 Jup Krt27 Krt28 Krt25 Krt26 Krtap29-1 Krt24 Krt20 LOC134481131 LOC102553726 Krtap5-8 Krt39 Dsg2 Krt36 Krt34 Krt35 Krt32 Krt31 AABR07001416.1 Krtap6-5 Krt18 Krt19 Krt17 Krt14 Krt15 Krt12 Krt13 Krt10 Krtap16-5 Krtap16-1 Krt6a Krt71 Krt78 Krt76 Krt77 Krt75 Krt72 Krt73 Krt40 Krtap1-3 Krtap1-1 Krtap1-5 LOC134478810 Krt82 Krt80 Krt85 Krt86 Krt83 Krt84 LOC102551497 Pkp1 Cdsn Klk5 Dsp Kazn Klk8 Ppl Dsg3 Tgm1 Krtap24-1 Sprr3 Stfa2l3 Casp14 Krtap13-1 Evpl Cela2a Spink6 Spink5 Perp Krtap10-9 Klk12 Pkp2 Pkp3 Lipk Dsg1 LOC120093742 Dsg4 Krtap11-1 Dsc1 Dsc2 Rptn Lipm Klk14 Klk13 Dsc3 Lipn Krtap31-2 Krtap31-1 Krt33b Krt33a HEME SIGNALING%REACTOME%R-RNO-9707616.1 Heme signaling Pgrmc2 Clec1b Tlr4 Xpo1 Bach1 Hba1 Apoa1 Apob Ly96 Slc46a1 Hbb REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%10231624 Regulation of CDH1 Expression and Function Ost4 Tmem258b Cbll1 H2ac18 Eps15 Ezh2 Psma4 Psma3 Psma6 Jup Psma5 Psma2 Psma1 Csnk2a2 Dad1 Ctnnd1 Csnk2a1 Psmd12 Psmd11 Suz12 Pcsk6 Hist1h2bq Ctnnb1 Psmd14 Psmd13 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Pomt1 H2aj Arhgap32 Pomt2 Src Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Banp Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Psmd1 Adrm1 Hist1h2ai Mogs Prkcsh Mtbp Pcsk7 Fyn Ganab Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Cdh1 Ctnna1 Sec11c Canx Sec11a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Uba52 Furin Vcl Ctsb H2ab2 Ubb Ctsl H2ac4 Ubc Ctss Smarca4 Pip5k1c Rpn2 Rpn1 Ostc Psmb6l1 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 97%10231614 Regulation of Homotypic Cell-Cell Adhesion Ost4 Tmem258b Cbll1 H2ac18 Eps15 Ezh2 Psma4 Psma3 Angptl4 Psma6 Jup Psma5 Psma2 Psma1 Csnk2a2 Dad1 Ctnnd1 Csnk2a1 Psmd12 Psmd11 Suz12 Pcsk6 Hist1h2bq Ctnnb1 Psmd14 Psmd13 Ddost Psmb5 Psmb4 Csnk2b Dnm2 Psmb7 Psmb6 Psmb1 Eed Psmb3 Psmb2 Pomt1 H2aj Arhgap32 Pomt2 Src Psma7 H3-3b Psmc5 Hist3h2ba Psmc2 Psmc1 Psmc4 Psmc3 H2bc18 Sp1 Banp Psmd7 Psmd6 H2az2 Psmd8 Psmd2 H2bc6 Rbbp4 H2bc4 Hist1h4m H2bc1 Rbbp7 Amot Psmd1 Adrm1 Hist1h2ai Mogs Prkcsh Mtbp Pcsk7 Fyn Ganab Zeb2 Cdh11 Adam19 Mphosph8 Zmym2 Hdac2 Ctbp1 Ctbp2 Hdac1 Twist1 Tle1 Kmt5a Kdm1a Zeb1 Dnttip1 Sirt1 Cdh1 Ctnna1 Sec11c Canx Sec11a Rack1 Spcs3 Rps27a Spcs1 Spcs2 Uba52 Furin Vcl Ctsb H2ab2 Ubb Ctsl H2ac4 Ubc Ctss Smarca4 Pip5k1c Rpn2 Rpn1 Ostc Psmb6l1 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME%R-RNO-112307.1 Transmission across Electrical Synapses Gja10 Gjc1 Gjd2 Panx2 Panx1 TRANSPORT OF SMALL MOLECULES%REACTOME%R-RNO-382551.1 Transport of small molecules Tusc3 Psma4 Psma3 Psma6 Erlec1 Psma5 Psma2 Psma1 Steap3 Aco1 Atp6v0b Psmd12 Psmd11 Atp6v0a4 Psmd14 Psmd13 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Psmb5 Atp6v1c1 Psmb4 Atp6v0c Psmb7 Psmb6 Psmb1 Atp6ap1 Psmb3 Psmb2 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Os9 Psma7 Slc29a3 Atp7b Atp6v0d2 Slc28a3 Atp10a Slc28a2 Psmc5 Atp10b Atp6v0d1 Slc29a1 Atp6v1b1 Atp10d Psmc2 Atp4a Atp6v0e1 Psmc1 Atp4b Slc5a6 Atp6v1g2 Psmc4 Slc5a8 Atp11b Atp6v1g1 Psmc3 Atp11a Atp6v1f Atp13a1 Atp6v1d Atp11c Rnf5 Sel1l Atp8b2 Slc2a9 Atp8b1 Slc2a12 Atp8b4 Slc45a3 Magt1 Atp8b3 Slc2a10 Psmd7 Slc46a1 Atp13a2 Psmd6 Slc5a10 Atp13a4 Atp13a5 Slc50a1 Psmd8 Mfsd4b4 Atp12a Fgf21 Psmd2 Atp2c1 Slc2a1 Atp2c2 Atp9b Slc2a4 Atp9a Slc2a3 Slc5a2 Slc2a7 Slc5a4 Psmd1 Adrm1 Slco1a4 Alb Atp7a Add1 Fbxl5 Slc22a2 Slc22a1 Slc22a3 Ryr2 Asic5 Ryr1 Asic4 Fkbp1b Lcn2 Clca1 Clca2 Asic1 Asic3 Asic2 Clca4 Trdn Trpc5 Trpc1 Trpc4 Clcn2 Slc25a22 Stoml3 Clcn1 Trpm2 Trpm1 Unc80 Ano10 Trpm8 Ano9 Trpm7 Ano8 Ano7 Ano6 Slc25a18 Ano5 Slc25a11 Trpm4 Ano4 Slc29a2 Trpm3 Ano3 Trpm6 Ano2 Ano1 Ttyh3 Ttyh1 Ttyh2 Stom Sgk3 Sgk2 Sgk1 Trpv5 Trpv4 Trpv6 Scnn1a Scnn1b Slco3a1 Clic2 Slco4a1 Unc79 Slco2a1 Scnn1g Slco4c1 Mcoln3 Slco1c1 Asph SLC16A2 Lrrk1 Trpa1 Slc17a3 Trpv1 Trpv3 Mcoln1 Mcoln2 Trpv2 Nalcn Tpcn1 Trpc4ap Tsc22d3 Clcn6 Clcn7 Best4 Clcn4 Clcn5 Nek4 Wwp1 Bsnd Best1 Best3 Clcnkb Clcnka Best2 Nr1h3 Slc10a6 Nr1h2 Abca1 Slc15a4 Cyb5r4 Abcg2 Cyb5r2 Cyb5r1 Cyb5rl Abcc1 Slc7a11 Slc7a10 Slc16a3 Slc16a8 Slc7a6 Slc7a7 Atp1b1 Atp1b3 Atp1b2 Slc16a1 Slc7a8 Slc7a9 Raf1 Slc30a10 Slc24a4 Slc41a2 Slc24a3 Slc24a2 Slc24a1 Slc44a3 Slc40a1 Slc44a4 Slc41a1 Cp Slc44a5 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc8a1 Slc39a8 Slc22a5 Slc9a1 Slc39a7 Slc8a2 Slc39a6 Slc30a5 Slc9a4 Slc11a1 Slc9a5 Slc11a2 Slc9a2 Slc8a3 Slc9a3 Slc31a1 Slc9a8 Slc9a9 Slc30a8 Slc9a6 Slc9a7 Slc39a14 Slc30a1 Adam22 Heph Slc24a5 Slc8b1 Plekha8 Hfe Steap4 Tfr2 Slc25a1 Slc5a12 Bsg Slc17a5 Furin GLTP Esyt3 Cptp Esyt2 A2m Cln3 P4hb Slc44a1 Slc44a2 Angptl8 Lmf1 Slc6a11 Lmf2 Slc6a12 Lpl Angptl4 Angptl3 Mttp Arf1 Apoc2 Lcat Lipg Ftl1 Lipc Apoc3 Fth1 Clta Apoa2 Slc22a4 Apoe Cltc Apoa4 Pcsk5 Apoa5 Pcsk6 Pltp Slc5a5 Slc12a1 Slc12a4 Slc12a5 Slc12a2 Fth1-ps5 Slc12a3 Slc12a6 Slc12a7 Slc34a1 Slc34a2 Tfrc Slc6a7 Atp2a1 Gnas Atp2b1 Atp2b4 Slc25a10 Atp2a3 Atp2b3 Atp2a2 Slc15a1 Trpc7 Ctns Slc15a3 Trpc3 Slc7a5 Cybrd1 Cand1 Abcf1 Abcb1 Ftmt Abcb6 Slc22a17 Abcb7 Ireb2 Abcb4 Slc27a1 Abcb5 Lcn12 Abcb8 Lcn9 Abcb9 Arl2bp Abcg4 Vegp2 Abcc3 Vegp1 Slc33a1 Abcg8 Abcc4 Slc27a4 Slc25a5 Abcg5 Abcc2 Apod Abcc5 Slc28a1 Abcc6 Slc27a6 Slc29a4 Apoa1 Abcc9 Abca12 Abcc10 Phb1 Eif2s3 Eif2s2 Eif2s1 Cftr Abca2 Abca5 Abca6 Abca3 Kcnj11 Abca9 Abca7 Slc13a5 Abca8 Emb Slc16a7 Slc13a3 Slc13a2 Ca1 Ca2 Ca4 Hba1 Hbb Rhag Slc4a1 Aqp1 Rab11a Hmox1 Hmox2 Slc3a2 Slc35d2 Slc36a4 Slc35c1 Slc35d1 Slc35b4 Slc35a3 Slc35a2 Slc35b3 Slc35a1 Slc35b2 Bmp1 Runx1 Slc26a2 Slc26a1 Slc26a6 Slc26a4 Slc26a3 Slc26a9 Slc26a11 Slc26a7 Rps27a Camk2a Skp1 Uba52 Myo5b Aqp9 Aqp8 Aqp7 Aqp11 Aqp5 Aqp4 Aqp3 Aqp2 Aqp12a Mip Aqp10 Ubb Ap2s1 Ubc Nceh1 Apobr Amn Slc6a5 Slc6a9 Soat2 Apoc1 Slc6a2 Slc17a8 Soat1 Lipa Slc17a6 Mylip Scarb1 Npc2 Npc1 Pcsk9 Slc20a2 Apoc4 Slc20a1 Ahcyl2 Vldlr Slc17a1 Arl2 Hdlbp Cubn Slc4a2 Afg3l2 Ldlrap1 Slc4a4 Slc4a3 Mcub Pmpcb Slc4a5 Cul1 Slc4a8 Spg7 Slc4a9 Micu2 Pmpca Slc13a4 Slc13a1 Micu3 Slc34a3 Micu1 Parl Slc4a10 Pheta2 Maip1 Mcu Rhcg Ldlr Rhbg Atp1a2 Fxyd3 Fxyd4 Atp1a1 Atp1a4 Zdhhc8 Fxyd1 Fxyd2 Atp1a3 Fxyd7 Fxyd6 Pln Cygb Esyt1 Gng10-ps1 Slc2a8 Ap2m1 Slc2a13 Slc5a11 Sar1b Slc5a3 Slc67a1 Slc25a26 Slc14a2 Prkaca Slc14a1 Prkacb Slc47a1 Slc22a15 Slc22a16 Slco1b2 Slc6a13 Slco2b1 Prkar1a Slc5a7 Prkar1b Calm3 Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Prkar2a Slc6a1 Slc6a4 Slc1a5 Slc6a3 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Slc17a7 Slc4a7 Slc32a1 Abcd1 Abcd2 Abcd3 Avpr2 Pex3 Pex19 Yme1l1 Slc1a1 Stoml2 Phb2 Slc1a3 Slc1a2 Apob Slc38a2 Slc1a7 Slc43a1 Slc1a6 Slc43a2 Slc6a20 Slc25a29 Slc38a1 Slc38a5 Slc3a1 Slc38a4 Slc38a3 Add3 Slc1a4 Slc7a3 Slc7a1 Slc6a6 Slc6a19 Slc6a15 Tf Slc6a14 Slc36a2 Slc36a1 Slc16a10 Mb Ngb Camk2g Camk2d Gpihbp1 Camk2b Mrs2 Slc22a12 Nipal4 Slc22a6 Dmtn Slc22a8 Nipal2 Slc22a7 Nipal3 Nipal1 Slc66a1 Add2 Nipa1 Avp Nipa2 Slc25a4 Azgp1 Lrrc8e Lrrc8a Lrrc8b Lrrc8c Lrrc8d Ankh Ap2b1 Pip Nedd8 Slc2a2 Slc5a1 Rnf185 Derl3 Derl2 Ap2a2 Ap2a1 Erlin2 Erlin1 Vcp Psmb6l1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%10230448 Assembly of collagen fibrils and other multimeric structures Mmp13 Mmp9 Pxdn Col10a1 Col3a1 Col5a2 Col15a1 Col5a3 Col24a1 Col5a1 Lox Pcolce Col11a1 Col11a2 Mmp7 Mmp3 Loxl2 Loxl1 Col4a1 Loxl4 Col4a2 Ctsb Loxl3 Col2a1 Col27a1 Ctsl Ctss Col8a1 Col8a2 Col18a1 Bmp1 Tll2 Tll1 Col7a1 Mmp20 DNA DAMAGE REVERSAL%REACTOME%R-RNO-73942.1 DNA Damage Reversal Alkbh5 Fto SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-RNO-416550.1 Sema4D mediated inhibition of cell attachment and migration Met Arhgap35 Rnd1 Rras Sema4d Rac1 Plxnb1 Rhoa OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%10230112 Other interleukin signaling Il16 Stxbp2 Csf1r Vamp2 Ptprz1 Stx1a Il34 Txlna Snap25 Sdc1 Csf1 Stx4 Stx3 Cd4 Casp3 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-390648.1 Muscarinic acetylcholine receptors Chrm4 Chrm1 Chrm3 Chrm2 Chrm5 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%10229220 Processive synthesis on the C-strand of the telomere Pold3 Terf2 Terf1 Rpa1 Tinf2 Fen1 Rpa2 Lig1 Acd Pold1 Terf2ip Rpa3 Pot1 Pold4 Pold2 Dna2 Wrn Pcna Blm FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-RNO-5654693.1 FRS-mediated FGFR1 signaling Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgf6 Fgf5 Fgf8 Fgf9 Nras Grb2 Kras Kl Sos1 Fgfr1 Hras Frs2 Fgf10 Fgf3 Frs3 Fgf22 Ptpn11 Fgf17 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 97%10230344 Metal sequestration by antimicrobial proteins Lcn2 S100a9 S100a8 Ltf ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones Atf6 Mbtps1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME%R-RNO-5654221.1 Phospholipase C-mediated cascade; FGFR2 Fgf18 Plcg1 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Fgf6 Fgf5 Fgf8 Fgf9 Fgf10 Fgf3 Fgf22 Fgf7 Fgf16 Fgf17 PRE-MRNA SPLICING%REACTOME%R-RNO-72163.1 pre-mRNA splicing Snrpg Snrpb Snrpd1 Ncbp2 Ncbp1 Snrpd3 Snrpepl2 Ppil2 Hspa8 Snrnp200 Phf5a Rnps1 Fam50a Smndc1 Pnn Znf830 Hnrnpr-ps2 Rnf113a2 U2surp Crnkl1 Cdc40 Aqr Pcbp2 Prcc Pcbp1 Ddx39b Magoh Upf3b Tfip11 Hnrnpr Dhx8 Wdr70 Hnrnpu Snrpa1 Rbm10 Steep1 Dhx38 Dhx35 C3h9orf78 Ptbp1 Eif4a3 Hnrnpc Hnrnpd Hnrnpf Ppwd1 Hnrnpk Hnrnpl Gcfc2 Dhx16 Ccdc12 Dhx15 Srsf19 Srsf11 Srsf12 Srrm1 Rbm8a Sde2 Slu7 Rnf113a1 Srrm2 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Nkap Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Hnrnph2 Hnrnph1 Leng1 Mfap1al1 Cactin Ppig Ppie Hnrnpa2b1 Srrt Rbmx2 Cwc22 Nsrp1 Cwc27 Cwc25 Prpf8 Wbp11 Prpf19 Prpf18 Snrnp40 Eftud2 Snip1 Fam32a Snrpn Alyref Cwc15 Cherp Yju2 Fus Gpatch1 Casc3 Magohb Pqbp1 Isy1 Rbmx Cdc5l Ybx1 Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Acin1 Srsf2 Rbm22 Hnrnpa3 Rbm17 Syf2 Ddx46 Bud31 Ddx41 Ddx42 Puf60 Cwf19l2 Polr2c Ctnnbl1 Polr2a Ppil4 Polr2b Ppil3 Polr2g Polr2h Hnrnpa1 Polr2e Ppil1 Polr2f Sap18 Polr2i Polr2j Tra2b Bud13 Bcas2 Snrpf Gtf2f2 Gpkow Gtf2f1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors Gipr Vipr2 Gnas Glp2r Vipr1 Gng3 Sct Gng5 Gcgr Gng4 Sctr Gng7 Gng8 Gngt1 Adcyap1 Gnb2 Vip Ghrh Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Ghrhr Gcg Gip Gng10-ps1 Glp1r LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230046 Lysosome Vesicle Biogenesis Hspa8 Clvs1 Ap1g2 Ap4m1 Clvs2 Cltb Dnajc6 Arf1 Clta Ap1b1 Cltc Vamp8 Ap1s3 Ap1s2 Txndc5 Ap1g1 Ap4s1 Dnm2 Gns Vamp7 Ap4e1 Vamp2 Sh3gl2 M6pr Ap4b1 Ctsz Arrb1 Hgs Ap1m2 Bloc1s1 Ap1m1 Dnase2 App Chmp2a PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%10228994 PKA-mediated phosphorylation of key metabolic factors Mlxipl TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-RNO-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk9 RET SIGNALING%REACTOME DATABASE ID RELEASE 97%10231234 RET signaling Mapk7 Dok1 Prkaca Prkacb Dok2 Dok4 Dok5 Dok6 Prkca Irs2 Pspn Gdnf Gab1 Frs2 Artn Shc1 Grb10 Nrtn Gfra1 Gfra2 Ret Rap1gap Grb7 Gfra4 Plcg1 Pik3cb Shank3 Pik3cd Gab2 Pik3ca Src Pik3r1 Shc3 Pik3r2 Pik3r3 Grb2 Sos1 Pdlim7 Ptpn11 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes Traf6 Rps27a Myd88 Prkci Ngfr Ubb Sqstm1 Ripk2 Ubc Uba52 Ngf Ikbkb Irak1 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 97%10229508 Negative regulation of the PI3K AKT network Cd28 Pip4k2b Ppp2r1b Pip4k2c Ppp2r1a Pip4k2a Cd86 Cd80 Strn Egfr Esr1 Esr2 Kl Gab1 Flt3 Rhog Fgf10 Trib3 Fgf3 Fgf22 Fgf7 Rac1 Ppp2r5b Trat1 Ppp2r5a Ntf3 Them4 Ntf4 Ppp2r5e Kit Ntrk2 Insr Bdnf Pip5k1a Src Fgfr3 Egf Kitlg Lck Pik3r5 Pik3r6 Pik3cg Icos Ier3 Phlpp1 Hgf Pdgfrb Pdgfra Met Ntrk3 Fgf16 Fgf17 Fgf18 Fgf20 Fgf2 Fgf23 Fgf1 Fgf4 Fgfr2 Ins1 Fgf6 Fgf5 Fgf8 Ins2 Fgf9 Klb Fgf19 Fgfr4 Ereg Grb2 Fyn Fgfr1 Pdgfa Pdgfb Btc Akt3 Akt2 Cd19 Akt1 Il1rap Gab2 Vav1 Pik3r1 Pik3r2 Erbb2 Pik3r3 Pip5k1b Il33 Tgfa Erbb3 Nrg2 Nrg1 Nrg3 Traf6 Mapk1 Hbegf Mapk3 Pik3ap1 Rac2 Irs1 Irs2 Ppp2cb Ppp2ca Areg Frs2 Irak4 Pik3cb Pik3cd Pik3ca Myd88 Ppp2r5d Pten Il1rl1 Pip5k1c Ptpn11 Irak1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest E2f7 E2f8 Ccne1 Cdk2 Cdkn1b Ccne2 Ccna1 Ccna2 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%10229762 Recycling pathway of L1 Kif4b Dnm3 Kif4a Mapk1 Dnm2 Numb Ap2b1 Sh3gl2 L1cam Ezr Src Dpysl2 Ap2a2 Ap2s1 Ap2a1 Msn Clta Cltc Ap2m1 Dnm1 Rdx MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases Mapk7 Mapk8 Mapk1 Ppp2r1b Ppp2r1a Mapk3 Mapk10 Mapk11 Ppp2cb Ppp2ca Fos Vrk3 Rps6ka3 Rps6ka5 Rps6ka1 Rps6ka2 Ppp2r5d Dusp3 Dusp4 Dusp7 Dusp6 Mapk14 Mapk9 Jun Atf2 Mapkapk2 Atf1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K Ntrk3 Ntf3 Src STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%10231722 Strand-asynchronous mitochondrial DNA replication Polg2 Twnk Ssbp1 Polg Polrmt VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296072.1 Voltage gated Potassium channels Kcng1 Kcnh1 Kcnh8 Kcnd3 Kcnh7 Kcnd2 Kcnh6 Kcnd1 Kcnh5 Kcnh4 Kcnh3 Kcnh2 Kcnq5 Kcnq1 Kcna7 Kcna6 Kcna5 Kcna4 Kcna3 Kcna10 Kcna2 Kcna1 Kcnv2 Kcnv1 Kcnb2 Kcnb1 Kcnf1 Kcnab1 Kcns3 Kcnab2 Kcns2 Kcns1 Kcnab3 Kcnc4 Kcnc3 Kcnc2 Kcnc1 Kcng4 Kcng3 Kcng2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Abcd3 Akr1c18 Akr1c19 Hsd3b7 Akr1c1 Akr1d1 Akr1c21 Akr1c9 Cyp46a1 Cyp27a1 Akr1c12l1 Slc27a5 Slc27a2 Akr1c3l1 Akr1c12 Akr1c13 Amacr Cyp39a1 MMR%REACTOME%R-RNO-5358508.1 MMR Pold3 Msh6 Rpa1 Msh2 Rpa2 Lig1 Pold1 Rpa3 Pms2 Mlh1 Pold4 Exo1 Pold2 Pcna SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 97%10230698 Sensory perception of taste Tas1r3 Tas2r40 Tas2r16 Tas2r13 Tas2r41 Tas2r136 Scnn1a Scnn1b Itpr3 Scnn1g Tas2r140 Tas2r105 Tas2r119 Tas2r107 Tas2r39 Gnat3 Tas2r38 Tas2r4 Tas2r3 Tas2r7 Gnb1 Gnb3 Tas1r2 Tas2r120 Tas1r1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D Psmd8 Psmd2 Ccnd1 Cdk4 Rps27a Psmd1 Adrm1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Uba52 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Ubb Psmc2 Psmc1 Ubc Psmc4 Psmc3 Psmd7 Psmd6 Psmb6l1 MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260910%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Zbtb18 Foxj3 Pdgfra Elovl7 Neurod1 Sox6 Hes5 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Atf2 Shc1 Max Pla2g4a Map3k9 Elk1 Mef2d Map3k7 Map2k6 Map3k5 Tgfb2 Tradd Hspb1 Traf2 Rac1 Cdc42 Mapk14 Mapkapk2 Ripk1 Mapkapk5 Map2k4 Map3k1 Rps6ka5 Mknk1 Grb2 Tgfbr1 Daxx Hras APOPTOSIS%WIKIPATHWAYS_20260910%WP1290%RATTUS NORVEGICUS Apoptosis Tnfrsf1a Akt1 Nfkb1 Traf1 Tp53 Bcl2l2 Xiap Rela Bnip3l Irf3 Irf4 Irf1 Irf2 Pmaip1 Tnfrsf10b Lta Irf7 Irf5 Fadd Irf6 Pik3r1 Diablol1 Bak1 Bid Tp73 Nfkbib Casp7 Jun Casp9 Bad Casp3 Tnfrsf25 Igf2 Casp2 Nfkbia Bax Fas Chuk Faslg Igf1r Dffa Dffb Tp63 Mapk10 Tradd Traf2 Ripk1 Map2k4 Map3k1 Ikbkb Ikbkg Prf1 Birc5 Tnfrsf1b Hells Bcl2l11 GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260910%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Pla2g4a Anxa1 Mt-co2 Nfkb1 Fkbp4 Nfkbia Tsc22d3 Nr3c1 Hspa4 Rras ESTROGEN METABOLISM%WIKIPATHWAYS_20260910%WP1302%RATTUS NORVEGICUS Estrogen metabolism Sult1e1 Nqo1 Gstm1 Comt Sult1a1 Arsl Cyp1a1 Cyp1b1 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260910%WP217%RATTUS NORVEGICUS Nuclear receptors Esrra Esrrb Rara Rarb Nr2f6 Thrb Nr1d2 Thra Nr2f2 Vdr Nr2f1 Nr1h3 Rorc Nr1h2 Ppard Ppara Esr1 Pparg Esr2 Rxrb Rxra Ror1 Rxrg Nr5a2 Nr5a1 Nr4a2 Nr3c1 Nr2c2 Nr2e1 Hnf4a Nr1i3 Nr1i2 LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260910%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Plin2 Pnpla2 Bscl2 Dgat2 Agpat5 Acsl1 Dgat1 Gpd2 Acsl3 Agpat3 Fitm2 Agpat4 Agpat1 Agpat2 Soat1 Lpin3 Aup1 Lipa Gpat2 Lpin1 INSULIN SIGNALING%WIKIPATHWAYS_20260910%WP439%RATTUS NORVEGICUS Insulin signaling Akt1 Pik3r1 Jun Igf1r Mapk10 Mapk9 Cyth3 Mapk8 Grb14 Mapk1 Trib3 Irs2 Map3k8 Grb10 Map3k6 Mapk3 Mapk4 Map3k4 Stxbp1 Stxbp2 Stxbp3 Stxbp4 Prkaa1 Prkaa2 Akt2 Reg1 Gyg1 Kif5b Cblc Tsc2 Cblb Tsc1 Prkcq Map3k3 Map3k2 Prkch Prkci Prkcb Prkcd Prkca Raf1 Shc3 Shc2 Insr Eif4ebp1 Flot2 Flot1 Map4k5 Map4k3 Rab4a Rps6kb1 Rheb Rps6kb2 Pik3cg Prkcz Pik3cd Egr1 Xbp1 Kif3a Tbc1d4 Pik3c2a Pik3c2g Map4k2 Ehd1 Map4k1 Ehd2 Snap25 Snap23 Lipe Rptor Arf1 Pik3c3 Gys1 Gys2 Pdpk1 Rhoj Rac2 Slc2a1 Slc2a4 Ptprf Foxo3 Foxo1 Cap1 Rrad Inpp4a Gab1 Fos Ppp1r3a Vamp2 Eif4e Gsk3b Rps6ka3 Rps6ka4 Gsk3a Rps6ka6 Rps6ka1 Mink1 Rps6ka2 Sgk3 Sos2 Sgk2 Crk Sos1 Pik3r2 Sgk1 Myo1c Enpp1 Map2k7 Mtor Pfkl Ptpn1 Ptpn11 Stx4 Arhgap33 Inppl1 Mapk12 Mapk13 Shc1 Pten Sh2b2 Map2k2 Map3k9 Map2k1 Elk1 Rapgef1 Map3k10 Map3k7 Map3k11 Map2k6 Map3k14 Map3k5 Mapk11 Rac1 Mapk14 Map2k4 Map3k1 Rps6ka5 Grb2 Hras Ikbkb S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260910%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction Akt2 Akt1 Smpd2 Plcb3 Pik3c2b Plcb2 Plcb1 Asah1 Sphk2 Akt3 Sphk1 S1pr1 Gnai1 Mapk1 S1pr3 Gnai3 Mapk3 Mapk4 Mapk12 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260910%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Akr7a3 Gstm1 Akr7a2 Ephx1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Pik3ca Hgf Ptk2b Ptk2 Itgb1 Stat3 Met Crk Sos1 Raf1 Ptpn11 Jun Pten Map2k2 Map2k1 Elk1 Rapgef1 Map4k1 Mapk8 Mapk1 Grb2 Src Rasa1 Mapk3 Hras Pxn Dock1 Crkl Pak1 Itga1 Rap1a Gab1 Rap1b Fos NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Mapk8 Map3k7 Chuk Cd40 Rela Ephb2 Ikbkb Ikbkg APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260910%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Tnfrsf1a Casp2 Nfkb1 Fas Faslg Cycs Casp6 Aifm1 Mapk10 Hspa1b Ripk1 Map3k1 Fadd Bid Casp7 Casp9 Casp3 BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260910%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Acadm Decr1 Hadha Hadhb Eci1 ADIPOGENESIS%WIKIPATHWAYS_20260910%WP155%RATTUS NORVEGICUS Adipogenesis Stat3 Socs3 Ins2 Nampt Nrip1 Ahr Tnf Lifr Prlr Cyp26b1 Foxc2 Wnt5b Twist1 Ebf1 Mif Retn Cyp26a1 Mbnl1 Frzb Cntfr Fas Gata3 Serpine1 Gata4 Gata2 Cfd Lpl Gh1 Il6 Nr3c1 Tgfb1 Hif1a Dvl1 Id3 Gtf3a Ndn Cisd1 Pck1 Pck2 Egr2 Lif Igf1 Bmp4 Bmp3 Wwtr1 Stat5a Bmp2 Stat5b Bmp1 Hnf1a Hmga1 Adipoq Rara Necab3 Epas1 Scd1 Sfrp4 Ptgis Rbl2 Rbl1 Nr2f1 Klf15 Nr1h3 Ncor1 Il6st Ucp1 Ppard Gadd45b Ppara Gadd45a Pnpla3 Pparg Cebpd Cebpb Ncoa2 Rxra Zmpste24 Ncoa1 Rxrg Rb1 Asip Osm Ppargc1a Celf1 Lpin3 Dlk1 Mixl1 Agt Mef2a Lpin1 Mef2b Plin2 Mef2c Klf5 Bscl2 Lep Spock1 E2f1 Cdkn1a Gdf10 Srebf1 Agpat2 Trib3 Irs2 Lipe Slc2a4 Foxo1 Mef2d SMALL LIGAND GPCRS%WIKIPATHWAYS_20260910%WP161%RATTUS NORVEGICUS Small ligand GPCRs Mtnr1a Cnr1 Cnr2 Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Ptafr S1pr1 Ptger3 Ptger1 S1pr3 Lpar1 BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260910%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Hsd3b6 Cyp21a1 Cyp17a1 HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260910%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Gria2 Camk2b Map2k1 Gria1 Ppa1 Prkce Drd1 Grin1 Grin2d Adcy8 Grin2c Drd4 Grin2b Mapk1 Acta1 Grin2a Mapk3 Nisch Camk4 Krit1 Prkaca Terf2ip Grm1 Grm5 SPINAL CORD INJURY%WIKIPATHWAYS_20260910%WP2433%RATTUS NORVEGICUS Spinal cord injury Tp53 Grin1 Btg2 Chst11 Bdnf Fkbp1a Ptprz1 Prkca Slit1 Slit2 Aqp4 Slit3 Pdyn Rgma Vcan Gja1 Ifng Sema6a Lilrb2 Nos1 Sox9 Tnfsf13b Casp3 Zfp36 Gap43 Arg1 Egr1 Prpg2 Omg Mmp9 Plxna2 Epha4 Mag Rtn4r Tacr1 Tlr4 Ngfr Cxcl10 Il6 Pla2g2a Tgfb1 Ccng1 Ntn1 Anxa1 Klk8 Il2 Rtn4 Gfap Il4 Selp Bcan Tnfsf13 C5 Gdnf Ccl2 Pla2g5 Mbp Cd47 Cxcl1 Fos Cxcl2 Pla2g6 Ppp3ca Fcgr2a Necab3 Ccnd1 Nos2 Ptpra Ncan Col4a1 Acan Il1a Il1b Xylt1 Nox4 Cdk1 Rock2 Gadd45a Il1r1 Vim E2f5 Rb1 E2f1 Mapk1 Mapk3 HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260910%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Pdp1 Pdp2 Pck1 Gpi Pdhx Psme3 Slc5a10 Sord Pfkl Eno1 Eno3 Eno2 Khk Pc Mpc1 Mpc2 Pdk4 Pgam2 Slc2a2 Pdk3 Pgam1 Akr1b1 Slc2a5 Pdk2 Pdk1 Tpi1 Pdhb Gapdh Tkfc Ldha Ldhb Fbp1 Dld Pklr Aldob Aldoc Aldoa Acly Pdha1 Pgk1 Slc5a1 Slc5a2 Pfkp Slc5a9 Got1 Mdh1 Mdh2 Got2 G6pc1 Hk1 METHYLATION%WIKIPATHWAYS_20260910%WP1282%RATTUS NORVEGICUS Methylation Pnmt Mat2a Mat1a Inmt Comt Hnmt MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260910%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Mmp9 Mmp11 Cep295nl Mmp23 Mmp24 Mmp14 Mmp15 Mmp16 Mmp2 Mmp28 Timp3 Timp2 Timp4 Bsg Tcf20 Mmp21 Tnf GPCRS OTHER%WIKIPATHWAYS_20260910%WP409%RATTUS NORVEGICUS GPCRs other Drd4 Prokr2 Adora2a Adgrg1 Cxcr1 Ednra Gnrhr Ntsr1 Htr7 Fshr Grm8 Htr2a Gpr61 Or1n1 Ccr5 Ccr2 Gpr176 Adra1d Cckbr Alg6 Adgrl2 Adgrl3 Gpr135 Sstr2 Smo Htr1f Taar3 Rxfp3 Taar2 Rxfp1 Taar5 Ghrhr Gpr183 C5ar2 F2r Or3a1e Or2a5 Chrm3 Chrm2 Hrh4 Gpr88 Or2f1 Drd3 Celsr2 Gpr18 Grpr Uts2r P2ry13 Gpr17 Ltb4r2 Lgr6 Or10a2 Cnr1 Ptgfr S1pr1 Grm1 GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260910%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Pik3ca Pik3cd Map2k1 Akt1 Ccnd1 Necab3 E2f1 Tp53 Cdkn1a Tgfb2 Ccne1 Erbb2 Dmp1 Egfr Mycb Tgfb1 Crebbp Rasl11b Smad2 Smad4 Raf1 Mapk1 Mdm2 Rb1 BURN WOUND HEALING%WIKIPATHWAYS_20260910%WP5057%RATTUS NORVEGICUS Burn wound healing Tp53 Col4a1 Ptgis Il1b Il10 Adora2b Epo Dll4 Pdgfa Arfgap1 Ccn2 Col1a1 Jun Syk Chp1 Ankrd1 Casp3 Syp Il1rl1 Glb1 Cdc25b Mmp9 Gpr176 Acta1 Igf1 TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260910%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Mapk8 Prkca Aimp2 Cebpb Maf Nqo1 Hmox1 Gclm Nfe2l2 Ephb2 TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260910%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Reg1 Nos2 Irf4 Il1b Irf1 Irf2 Prkcd Socs3 Ptpn11 Ifng Spi1 Eif2ak2 Cxcl9 Ifnb1 Ifngr2 Cxcl10 Oas1a Ifngr1 Psmb9 Jak2 Gbp1 Jak1 Hist1h4m Tap1 Ciita Cybb Irf8 Isg15 Irf9 Ifit2 RETINOL METABOLISM%WIKIPATHWAYS_20260910%WP1297%RATTUS NORVEGICUS Retinol metabolism Rdh10 Adh5 Adh4 Rara Adh1 Rarb Bco1 Npc1l1 Rpe65 Rbp7 Abcg8 Abcg5 Rbp4 Scarb1 Cyp2e1 Retsat Crabp2 Cd36 Lrat Rlbp1 Rxrb Rxra Rxrg Cyp26b1 Cyp26a1 Lpl Sult1a1 Dhrs3 Aldh1a1 Sult2b1 Cd36l1 Rdh12 Aldh1a3 FOLIC ACID NETWORK%WIKIPATHWAYS_20260910%WP1311%RATTUS NORVEGICUS Folic acid network Cat Pnpo Xdh Mthfr Selenok Ptgis Mt-co2 Fads2 Mt-co1 Gpx1 Gpx3 Gpx6 Alox5 Msrb1 Mtr Selenow Kmo Sod1 Ptgds Txnrd2 Cbs NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260910%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Rara Rarb Vdr Abcg5 Nr1h3 Cyp2e1 Ppard Ppara Pparg Cyp26a1 Abcb1a Abcd2 Cyp27b1 Abcd3 Cyp2c11 Abcb4 Cyp4b1 Cyp2b2 Cyp8b1 Abcg1 Abca1 Abcc3 Cyp24a1 Abcc2 Cyp7a1 Abcb11 Nr1i3 Nr1i2 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Akt1 Stat3 Cblb Prkcb Tnfrsf10b Prkca Raf1 Pik3r1 Bad Pik3cg Stap1 Mitf Socs5 Socs4 Matk Socs6 Ptpru Csf2rb Stat5a Cltc Sh3kbp1 Stat5b Plcg1 Vav2 Fgr Dok1 Hck Kit Btk Spred1 Mpdz Rps6ka1 Spred2 Grb7 Ptpn6 Abl1 Fyn Grap Crk Lyn Sos1 Plce1 Pik3r2 Tec Fes Ptpn11 Shc1 Sh2b2 Map2k1 Jak2 Mapk1 Grb2 Grb10 Src Rasa1 Hras Crkl INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260910%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Cftr Nherf1 Fblim1 Ezr Rab7a Rab11a CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260910%WP590%RATTUS NORVEGICUS Cardiovascular signaling Vav2 Akt1 Col4a1 Erbb2 Casp6 Hspa1b Arhgef7 Pdgfra Col11a1 Stmn1 Col1a1 Tnc Rras2 Wnt2 Vegfd Casp3 Wasf1 Selenop Vwf Casp2 Egf Capn6 Col5a1 Map2k6 Col4a2 Cfl1 Pgf Thbs2 Hspb1 Mapk8 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260910%WP302%RATTUS NORVEGICUS Proteasome degradation Psmb1 Psmd3 Psmd2 Psmd5 Psmd4 Psmb2 Ube2d3 Ube2d1 Psmc6 Psmc5 Psma5 Psmc2 Rpn2 Psma2 Psmb9 Psmc4 Psmc3 Rpn1 Psme2 Psme1 Psmd12 Psmd11 Ube2b Psmd13 Uchl3 Psmb8 Psmb6l1 Psmb5 Psmd6 Psmb7 Psmd8 Uchl1 TCA CYCLE%WIKIPATHWAYS_20260910%WP347%RATTUS NORVEGICUS TCA cycle Pdk3 Pdk2 Fh Pdhb Sdhc Sdhb Sdha Idh3b Afdn Suclg1 Dld Suclg2 Ogdh Pdha1 Mdh1 Pc Mdh2 Pdk4 VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260910%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Akt1 Pgf Rac1 Prkci Mapkapk2 Prkca Sh2d2a Raf1 Nos3 Mapk1 Hspbp1 Vegfc Grb2 Pik3r3 Vegfb Src Pxn Casp9 Bad Shc1 Plcg1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260910%WP146%RATTUS NORVEGICUS Nucleotide metabolism Adss2 Sat1 Srm Dhfr Pold1 Prps2 Polb Impdh1 Nme2 Mthfd2 Hprt1 Polg IRINOTECAN PATHWAY%WIKIPATHWAYS_20260910%WP124%RATTUS NORVEGICUS Irinotecan pathway Abcc2 Bche Abcc1 Ces1f Ces1e Ces1d Ces2c Abcg2 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP517%RATTUS NORVEGICUS Notch signaling pathway Notch2 Lfng Notch3 Psen1 Psen2 Crebbp Dll4 Hes5 Aph1a Ncstn Dtx2 Dtx3 Dtx4 Dll3 Dvl1 Rbpjl Maml1 Ctbp1 Ctbp2 Hdac1 Mfng Dvl2 Hes1 Numb Dvl3 Jag2 Jag1 Kat2a Rfng Numbl Notch1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP1292%RATTUS NORVEGICUS One carbon metabolism Mthfr Mat1a Mthfd1l Ahcy Folh1 Mtrr Ftcd Ahcyl2 Bhmt Tcn2 Dnmt3a Aldh1l1 Shmt1 Gart Dhfr Mtr Mthfd2 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260910%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Mapk8 Mafg Map2k1 Nfe2l2 Cyp2e1 Prkcb GLUCURONIDATION%WIKIPATHWAYS_20260910%WP1276%RATTUS NORVEGICUS Glucuronidation Ugt2b1 Ugt2b7 Pgm2 Pgm5 Ugt2b35 Ugt2b34 Ugt2a1 Ugp2 Ugdh Pgm1 Hk1 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Ptk2 Gsk3b Cblc Erbb2 Abl1 Egfr Crk Sos1 Prkca Shc2 Map2k7 Eif4ebp1 Mtor Rps6kb1 Jun Ereg Hbegf Bad Camk2a Pak4 Tgfa Nrg2 Map2k1 Elk1 Egf Nrg1 Areg Btc Nrg4 Cdkn1a Nrg3 Pik3r5 Cdkn1b Akt3 Mapk8 Mapk1 Grb2 Src Hras Stat5a Gab1 Plcg1 STATIN PATHWAY%WIKIPATHWAYS_20260910%WP145%RATTUS NORVEGICUS Statin pathway Cyp7a1 Apoc1 Mttp Soat1 Lpl Scarb1 Hmgcr Apoe Lcat Abca1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260910%WP173%RATTUS NORVEGICUS Oxidative stress response Cat Nfkb1 Xdh Hmox1 Mapk10 Mapk14 Nfix Sod3 Sod2 Txn2 Cyba Gstt2 Nqo1 Mgst1 Gpx3 Junb Cyp1a1 Sod1 Txnrd2 Fos NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260910%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Rad50 Prkdc Xrcc4 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260910%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Adh5 Adh4 Adh1 Cyp1a1 Aldh2 Aldh1a1 Cyp4a2 Cyp2e1 Cyp3a2 Adh7 Adh6 Acad10 SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260910%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Tbxas1 Selenop Cat Fads1 Pnpo Xdh Mthfr Selenok Ptgis Mt-co2 Fads2 Mt-co1 Gpx1 Gpx3 Gpx6 Alox5 Mtr Kmo Sod1 Ptgds HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260910%WP1296%RATTUS NORVEGICUS Homologous recombination Pold2 Rad51 Brca2 Rad52 Pold4 Rad50 Pold3 Pold1 Fsbp Nbn SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260910%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Htr2a Htr1a Ppp3ca Grin2d Nlgn1 Adra1a Arc Plek Prkcb Crh Htr2c Fos IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Pik3ca Akt1 Nfkb1 Ptk2 Stat3 Mmp2 Prkcb Prkca Mapk7 Raf1 Socs3 Ywhaq Kcnip3 Ywhab Pik3r1 Fcer2 Ppp2ca Bcl2l1 Rack1 Gab2 Dnm1 Lck Vcl Chek1 Rps6kb2 Bad Il3ra Il3 Id1 Pik3cd Bmx Bax Mmp9 Gata2 Rac2 Selp Slc2a1 Matk Foxo1 Csf2rb Stat5a Gab1 Stat5b Rara Gsk3b Hck Gsk3a Ptpn6 Fyn Crk Lyn Sos1 Pik3r2 Tec Fes Rxra Ptpn11 Syk Atf2 Shc1 Map2k1 Rapgef1 Spi1 Hspb1 Rac1 Cdc42 Mapk14 Mapk9 Mapkapk2 Jak2 Mapk8 Jak1 Mapk1 Grb2 Src Mapk3 Hras Pxn Crkl Birc5 Prkaca Pak1 Tnfrsf1b Rap1a Bcl2l11 MONOAMINE GPCRS%WIKIPATHWAYS_20260910%WP276%RATTUS NORVEGICUS Monoamine GPCRs Drd1 Drd4 Adra1a Htr2c Htr1a Htr7 Htr2a Adra2a Adra2c Adra2b Htr4 Chrm1 Adra1d Hrh1 Htr6 Chrm5 Chrm4 Hrh2 Adrb1 Drd5 Adra1b Htr1f Adrb3 Htr1d Htr5b Htr5a Chrm3 Chrm2 Drd3 INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260910%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Akt1 Eif4e Tsc2 Gsk3a Tsc1 Rps6ka1 Sos1 Raf1 Eif4ebp1 Mtor Rps6kb1 Rheb Bad Shc1 Rptor Pik3c3 Gys1 Mapk1 Gys2 Ins1 Acly Irs2 Pfkfb2 Foxk1 Grb2 Grb10 Akt1s1 Rps6 Mapk3 Mlst8 Foxo1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260910%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260910%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Mterf1 Esrra Ppp3ca Nrf1 Ppargc1b Gabpa Myef2 Gabpb2 Tfam Pprc1 Ppargc1a Camk4 Tfb1m Tfb2m Prkar1b GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260910%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Cyp21a1 Cyp17a1 Cyp11a1 Akr1c9 Hsd11b1 Hsd11b2 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP547%RATTUS NORVEGICUS Complement and coagulation cascades Serpine1 Cfd F2r Cr2 Serping1 Cr1l Kng2l1 C3ar1 Serpinf2 Mbl1 Fgb Masp1 Masp2 Tfpi F2 C8b F3 F7 F8 F9 Plaur Cfb C1qb C1qa Vwf Cd59b Cfh Cfi Plg Klkb1 Kng2 C2 Proc C4 C6 C9 Serpind1 F13b Cd46 F10 C1s C1r F12 Plat Thbd Plau Pros1 Serpinc1 A2m Cpb2 Cd55 C1qc RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260910%WP376%RATTUS NORVEGICUS Renin angiotensin system Agtr2 Pik3ca Ace2 Ren1 Ptk2b Enpep Ptk2 Ctsa Nln Stat3 Pak6 Rela Cma1 Lnpep Prkcq Pak3 Pak2 Pak5 Ace Anpep Mas1 Itpr3 Itpr2 Raf1 Itpr1 Jun Mapk10 Fos Map2k7 Atf2 Mapk13 Agt Shc1 Pak4 Elk1 Plcb1 Rac1 Ptgir Mapk9 Jak2 Mapk8 Map2k4 Mapk1 Map3k1 Grb2 Mapk3 Ikbkb Ikbkg Ctsg Prkaca Pak1 Cpa3 Mme Agtr1 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP358%RATTUS NORVEGICUS MAPK signaling pathway Tnfrsf1a Akt1 Nfkb1 Tp53 Rela Pak2 Cacng8 Cacna1g Cacna1h Cacna1e Cacng7 Cacna1f Cacna1c Cacna1d Cacna1a Cacna1b Jun Cacng1 Fgf2 Cacng4 Casp3 Fgf1 Cacng5 Fgf4 Fgf3 Cacng3 Fgf6 Fas Fgf5 Chuk Elk4 Faslg Fgf8 Fgf7 Cacna1s Fgf9 Map3k20 Mapk10 Lamtor3 Prkcg Tgfb1 Nras Flna Rras Rasgrp3 Rasgrp4 Rasgrp1 Flnc Rasgrp2 Flnb Jund Nlk Stk4 Tgfb3 Pdgfrb Nf1 Tmem97 Ppp3cc Ppp3cb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Rasgrf2 Tab2 Cd14 Fgf16 Fgf17 Fgf14 Ppp5c Pla2g4b Traf6 Egfr Fgf18 Pla2g4e Fgf19 Pla2g4d Gadd45a Braf Fgf12 Fgf13 Fgf10 Fgf11 Nfkb2 Nfatc1 Pdgfa Mapt Nfatc3 Fgf20 Prkacb Ngf Cacna2d1 Cacna2d3 Cacna2d4 Gna12 Dusp16 Mef2c Cdc25b Ppm1b Ptpn7 Ptpn5 Dusp3 Ntf4 Dusp2 Hspa1l Dusp4 Ntf3 Arrb2 Arrb1 Dusp10 Dusp9 Mapk9 Dusp8 Cacnb4 Mapk8 Cacnb1 Cacnb2 Mapk1 Taok2 Taok1 Taok3 Map3k8 Mos Ntrk2 Map3k6 Ntrk1 Mapk3 Rapgef2 Mapk8ip1 Map3k4 Mapk8ip3 Il1r2 Prkaca Akt2 Map3k2 Bdnf Prkcd Prkca Raf1 Map4k3 Map4k2 Map4k1 Fos Ppp3ca Rps6ka3 Rps6ka4 Il1a Il1b Sos2 Crk Sos1 Il1r1 Map2k7 Stmn1 Rras2 Atf2 Mapk13 Pla2g4a Map2k1 Elk1 Egf Map3k7 Map3k11 Map2k6 Map3k14 Map3k5 Tgfb2 Hspb1 Traf2 Rac1 Cdc42 Mapk14 Akt3 Mapkapk2 Mapkapk5 Map2k4 Map3k1 Mknk1 Grb2 Tgfbr1 Daxx Rasa1 Hras Ikbkb Ikbkg Crkl Pak1 Rap1a PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260910%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Ces2j Esd Pon3 Ces5a Lipa Pon1 Pon2 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260910%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Agtr2 Ren1 Nos3 Agtr1b Bdkrb2 Kng2 Ace Agt Kng2l1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260910%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton Pik3ca Ptk2 Pak6 Pak3 Pak2 Pak5 Ins2 Pik3r1 Pik3r3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Nras Rras F2r Chrm3 Pdgfrb Chrm2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Cd14 Fgf16 Fgf17 Fgf14 Egfr Fgf18 Fgf19 Braf Fgf12 Fgf13 Fgf10 Fgf11 Pdgfa Fgf20 Gna12 Pak4 Pik3r5 Mapk1 Mos Mapk3 Mapk4 Cfl2 Actb Pip4k2b Pfn1 Pip4k2a Arhgef6 Arhgef1 Myh10 Nckap1 Slc9a1 Actg1 Ssh3 Ssh2 Raf1 Ssh1 Mylk Arpc5 Rhoa Enah Baiap2 Git1 Fgf23 Rassf7 Gna13 Fgd1 Vcl Bcar1 Csk Pik3cg Tmsb4x Arhgap35 Pik3cd Wasf2 Gsn Apc Limk1 Rock1 Pik3c2a Pip5k1b Chrm1 Pik3c2g Pip5k1a Chrm5 Chrm4 Pik3c3 Ins1 Sos2 Crk Sos1 Pik3r2 Ezr F2 Arhgef7 Pdgfra Rras2 Wasf1 Map2k1 Egf Cfl1 Pik3c2b Rac1 Cdc42 Pxn Dock1 Pak1 Itga1 FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260910%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Akr1b1 Slc2a5 Tpi1 Naglt1 Tkfc Fbp1 Aldob Gpi Aldoa Psme3 Slc5a10 Sord Pfkl Pfkp Slc5a9 Khk G6pc1 Hk1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260910%WP469%RATTUS NORVEGICUS Glutathione metabolism Gclm Ggt5 Gss Gstm6 Gstm3 Gstm2 Anpep G6pdx Gstt1 Ggt1 Oplah Gstt2 Gpx3 PEPTIDE GPCRS%WIKIPATHWAYS_20260910%WP131%RATTUS NORVEGICUS Peptide GPCRs Agtr2 Bdkrb2 Cxcr1 Ednra Gnrhr Ntsr1 Fshr Ccr5 Ccr2 Cckbr Tacr1 Sstr2 Ghsr Cckar Ednrb Npy1r Npy5r Ntsr2 Brs3 Mc2r Oprd1 Cxcr4 Ccr7 Cxcr6 Oprl1 Ccr6 Ccr3 Galr2 Galr3 Galr1 Grpr Npy4r Lhcgr Sstr5 Sstr4 Sstr3 Sstr1 Avpr1b Mc5r Oprm1 Tacr3 Tacr2 Fpr1 Fpr3 C3ar1 Nmbr Fpr2 Bdkrb1 Tshr Ccr10 Mc4r Tac4 Oxtr Npy2r Mc3r Oprk1 Agtr1 CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260910%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Prkaa2 Plcb3 Plcb2 Plcb1 Snap23 Prkcg Cftr Nherf1 Ezr Ppp2ca Rack1 Plcz1 Prkaca Nherf2 Pdzk1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260910%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 Ndufab1 Ndufc1 Coxfa4 Ndufc2 Ndufa5 Gzmb Atp5pb Gzmc Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 Mt-atp6 Mt-nd6 Atp5mc1 Mt-nd1 Mt-nd3 Mt-nd4l Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Pik3ca Tp53 Prkd3 Eif2ak3 Ube2k Gstk1 Herpud1 Sqstm1 Fth1 Acta2 Prdx1 Abcc4 Vcp Txn Pmf1 Gstm5 Gstm4 Ubb Pik3r1 Slc1a4 Pik3r3 Mafk Actg2 Fosl1 Bach1 Dhcr7 Jun Akr1a1 Slc35b1 Dnajc5 Aldh3a1 Ftl1 Xpo1 Gsto1 Gsto2 Mgst2 Abcc1 Cbr1 Gstp1 Pik3r6 Taldo1 Dnajb4 Actc1 Nqo2 Fmo1 Akr1b10 Prkcg Brca1 Nras Usp14 Rras Ran Nqo1 Gstm1 Crebbp Mafg Ugdh Hmox1 Gclm Cdkn1a Nfe2l2 Pik3r5 Mapk9 Sod3 Mapk8 Sod2 Mapk1 Gstt2 Mgst1 Acta1 Mapk3 Prkce Actb Prkcq Scarb1 Prkci Prkcb Actg1 Prkcd Prkca Mapk7 Raf1 Sod1 Prkcz Pik3cd Pik3c2a Pik3c2g Gss Gstm6 Gstm3 Gstm2 G6pdx Gstt1 Abcc3 Pik3c3 Slc2a1 Gsk3b Fyn Pik3r2 Map2k7 Rras2 Map2k1 Map3k7 Map2k6 Pik3c2b Psmc6 Psmc5 Ldhb Psmc2 Mapk14 Psmc4 Psmc3 Map3k1 Aldoa Akr7a3 Akr7a2 Ephx1 Hras ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260910%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Gast Ins2 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260910%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Nfkb1 Itpr3 Itpr1 Nos3 Jun Gsto1 Actc1 Il6 Prkcg Prkd1 Ets2 Rxfp1 Rgs4 Rgs5 Rgs2 Rgs3 Rgs1 Crcp Rgs9 Rgs6 Rgs7 Plcg2 Myl4 Mylk2 Myl2 Rxfp2 Atf5 Atf3 Maff Pkib Calca Grk5 Grk4 Atf6b Gnaq Pkia Grk6 Pkig Gngt1 Gucy1a1 Dgkz Gnb2 Gnb1 Gnb4 Gnb3 Rln1 Gng13 Ryr2 Atp2a3 Atp2a2 Oxt Adm Prkacb Ywhah Ywhag Ywhae Adcy3 Camk2a Adcy4 Adcy2 Guca2b Adcy7 Guca2a Crhr1 Adcy5 Creb3 Adcy9 Cald1 Pde4b Prkar1a Arrb2 Rgs20 Arrb1 Camk2g Rgs17 Camk2d Igfbp3 Gng3 Rgs19 Gng2 Lpar1 Igfbp4 Vkorc1l1 Rgs14 Gng7 Acta1 Igfbp1 Rgs16 Pde4d Gng8 Prkar2b Rgs10 Ackr5 Corin Ramp3 Camk2b Prkce Actb Prkcq Prkch Prkcb Actg1 Crh Prkcd Prkca Ywhaq Ywhab Gja1 Nos1 Prkcz Plcg1 Fos Prkar1b Gabpa Il1b Oxtr Atf2 Plcb3 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Il1rap Peli1 Akt1 Irak4 Nfkb1 Irak3 Irak2 Tollip Capn1 Elp1 Rela Sirpa Il1a Capns1 Sqstm1 Il1b Tab1 Traf6 Il1rn Il1r1 Ptpn11 Nfkbib Prkcz Map2k1 Nfkbia Map3k7 Chuk Map3k14 Mapk8 Mapk1 Mapk3 Il1r2 Plcg1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260910%WP632%RATTUS NORVEGICUS Cholesterol metabolism Srebf1 Apoc1 Lpl Scarb1 Hmgcr Fdps Apoe Idi1 Mvk Rusc1 Apoc2 Fdft1 Lss Hmgcs1 Mvd Msmo1 Soat1 Dhcr7 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260910%WP227%RATTUS NORVEGICUS Osteoblast signaling Slc34a1 Bglap Pth Pdgfra Fgf23 Tnfsf11 Col1a1 Pdgfrb TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Tnfrsf1a Akt1 Psmd3 Nfkb1 Ptk2 Rela Fadd Tnf Nfkbib Casp7 Casp3 Casp2 Nfkbia Chuk Flna Hdac1 Nr2c2 Tab2 Traf6 Crebbp Nfkb2 Ywhah Ywhag Ywhae Map3k8 Prkaca Akt2 Elp1 Map3k3 Map3k2 Ywhab Ppp2ca Rack1 Nkiras1 Nkiras2 Rps6kb1 Tbkbp1 Rps11 Rpl6 Rps13 Prkcz Pias3 Fbl Rpl30 Ube2i Dpf2 Kcnq1 Polr1b Rnf216 Polr1a Polr1g Fbxw11 Polr1e Casp8ap2 Txlna Tank Gtf2i Actl6a Smarce1 Tifa Ube2d2 Polr2sl1 Btrc Nfkbiz Glg1 Bag4 Ripk2 Ripk3 G3bp2 Dcaf7 Cops3 Cav1 Gab1 Capn3 Kpna6 Mcc Kpna3 Kpna2 Gsk3b Dap Cul1 Rel Ccar2 Traf4 Mcm7 Pfdn2 Faf1 Csnk2a1 Tnfrsf8 Mark2 Hdac2 Smarcb1 Alpl Rasal2 Akap8 Csnk2b Rpl8l1 Cyld Fkbp5 Mcm5 Ptpn11 Tnip2 Tnip1 Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Fancd2 Ktn1 Pebp1 Pkn1 Lrpprc Mtif2 Map3k14 Tradd Hspb1 Traf2 Psmc2 Ripk1 Psmc3 Map3k1 Psmd12 Psmd13 Src Ikbkb Ikbkg Psmb5 Psmd6 Tnfrsf1b ESTROGEN SIGNALING%WIKIPATHWAYS_20260910%WP1279%RATTUS NORVEGICUS Estrogen signaling Cdk7 Akt1 Taf7 Nfkb1 Taf6 Taf5 Shc2 Jun Chuk Brca1 Hdac1 Fos Ccnd1 Gngt1 Crebbp Hdac2 Sos1 Braf Esr1 Gnb1 Map2k1 Elk1 Ilk Mnat1 Hdac3 Hdac5 Taf13 Taf12 Gtf2f2 Tbp Mapk14 Mapk9 Ccnh Gtf2b Gtf2e1 Polr2c Mapk1 Polr2a Polr2b Taf9 Polr2g Grb2 Polr2h Src Polr2f Polr2i Hras Ikbkb Polr2j Gtf2h2 Gtf2h1 Prkaca Gtf2h4 Gtf2h3 Ercc3 Gper1 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260910%WP160%RATTUS NORVEGICUS Glycogen metabolism Gyg1 Gsk3b Gbe1 Calm3 Phkb Gsk3a Ppp2r3a Ppp2r5b Calm2 Ppp2r5a Ppp2r2c Ppp2r2b Phka1 Phka2 Ppp2cb Pygb Phkg1 Phkg2 Agl Ppp2r2a Ptpa Ppp2ca Ppp2r1a Ugp2 Pgm1 Gys1 Gys2 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260910%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Msra Msrb2 Cyp1a1 STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260910%WP316%RATTUS NORVEGICUS Striated muscle contraction Tnni3 Tnni2 Tnni1 Tnnc2 Tnnc1 Tmod1 Myh3 Actn3 Mybpc3 Actc1 Actn4 Myl9 Acta2 Actg1 Vim Acta1 Tnnt3 Tnnt2 Tnnt1 Tpm4 Tpm3 Tpm2 Neb Myl2 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Akt1 Nfkb1 Ptk2b Ptk2 Stat3 Ppp2r3a Cd40 Ppp2r5b Ppp2r5a Ppp2r2c Ppp2r2b Ppp2cb Prkcd Raf1 Socs3 Pik3r1 Ppp2r2a Ptpa Eif4ebp1 Ppp2ca Ppp2r1a Gab2 Rps6kb1 Jun Casp9 Bad Casp3 Bmx Ppp2r3b Hsp90aa1 Il6 Foxo4 Cdk5r1 Ppp2r5c Il6r Cdk9 Ppp2r5e Cdk5 Hdac1 Nlk Foxo3 Foxo1 Tmem97 Stat5a Gab1 Stat5b Plcg1 Fos Hnf1a Fgr Eif4e Gsk3b Hck Btk Erbb2 Rps6ka2 Il6st Fyn Lyn Crebbp Sos1 Pik3r2 Tec Sgk1 Fes Cebpb Ncoa1 Rb1 Mapt Ptpn11 Inppl1 Shc1 Map2k2 Map2k1 Map3k7 Map2k6 Hspb1 Rac1 Mapk14 Mapkapk2 Jak2 Mapk8 Jak1 Map2k4 Mapk1 Grb2 Daxx Mapk3 Hras Pxn Map3k4 FOCAL ADHESION%WIKIPATHWAYS_20260910%WP188%RATTUS NORVEGICUS Focal adhesion Pik3ca Akt1 Hgf Ptk2 Itgb1 Met Pak6 Pak3 Pak2 Pak5 Pik3r1 Vegfc Vegfb Jun Bad Igf1r Comp Ppp1r12a Tnn Kdr Tnr Igf1 Col1a2 Lama5 Pdgfrb Reln Lama3 Lama4 Mylk2 Thbs1 Tln1 Thbs4 Blk Vasp Srms Txk Pdgfc Chad Itga8 Itga6 Itga9 Erbb2 Vtn Itga3 Egfr Pdgfb Itga10 Ccnd2 Cav3 Cav2 Braf Tesk2 Tnk2 Ptk6 Col4a6 Ibsp Pelo Pdgfa Itgax Itgav Itgam Col1a1 Itgae Itgal Diaph1 Itgad Itgb8 Itgb6 Pak4 Itga2b Itgb5 Itgb2 Actn1 Itgb3 Col11a2 Lamb3 Pik3r5 Spp1 Lamb1 Col6a2 Map2k3 Styk1 Zyx Lamc1 Mapk9 Pip5k1c Mapk8 Mapk1 Mapk4 Akt2 Actb Capn1 Actg1 Mapk7 Raf1 Shc3 Mylk Vcl Bcar1 Pik3cg Pik3cd Rock1 Pdpk1 Rac2 Cav1 Fgr Ccnd1 Gsk3b Hck Col4a1 Fyn Crk Rock2 Sos1 Pik3r2 Pdgfra Col11a1 Tnc Mapk12 Shc1 Vegfd Pten Selenop Map2k2 Vwf Map2k1 Elk1 Egf Rapgef1 Col5a1 Col4a2 Map2k6 Ilk Pgf Thbs2 Rac1 Cdc42 Mapk14 Akt3 Grb2 Src Hras Pxn Dock1 Pak1 Rap1a Rap1b STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP66%RATTUS NORVEGICUS Steroid biosynthesis Hsd3b5 Hsd17b3 Hsd3b1 Hsd17b4 Hsd3b6 Hsd17b1 Hsd17b2 Cyp17a1 F13b Hsd17b7 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260910%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Glyat IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Il5 Akt1 Nfkb1 Ptk2b Stat3 Prkcb Prkcd Raf1 Shc2 Pik3r1 Alox5 Jun Pik3cg Nfkbia Bax Foxo3 Stat5a Stat5b Gsk3b Hck Btk Gsk3a Rps6ka1 Ptpn6 Lyn Pik3r2 Ptpn11 Itgam Syk Atf2 Shc1 Sh2b2 Pla2g4a Elk1 Itgb2 Rapgef1 Cdkn1b Rac1 Mapk14 Mapk9 Jak2 Jak1 Mapk1 Grb2 Rap1gap Ctnnb1 Mapk3 Hras Pim1 Sox4 Crkl Sdcbp Alox5ap Hcls1 Il5ra Unc119 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260910%WP270%RATTUS NORVEGICUS Tryptophan metabolism Ddc Tph1 Aldh3a2 Aldh9a1 Inmt Cyp2j3 Hsd17b10 Cyp2b15 Wars1 Cyp2j4 Prmt1 Tdo2 Cyp4f1 Cyp2e1 Cyp2f2 Aadat Cyp7b1 Ogdh Aanat Afmid Gcdh Mdm2 Aoc1 Dhcr24 Haao Asmt Cyp2d26 Echs1 Kynu Cyp2a2 Cyp2a1 Ube3a Acmsd Ido1 Hadh Cat Cyp1a1 Aldh2 Cyp1b1 Aldh1a1 Acad10 VEGFR 3 SIGNALING%WIKIPATHWAYS_20260910%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Itpkc Flt4 Akt1 Nos3 Mapk1 Vegfc Grb2 Mapk3 Casp9 Bad Shc1 Pik3cg Vegfd Plcg1 TRANSLATION FACTORS%WIKIPATHWAYS_20260910%WP149%RATTUS NORVEGICUS Translation factors Etf1 Gspt2 Eif4e Cluh Eif2ak3 Eif4ebp1 Eef1a2 Eef1d Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif2ak2 Eif4ebp2 Eif3f Eif4g1 Eif4g3 Eif3b Eif3a Eif1a Eif5b Eif5a Eif2b3 Eif2b2 Eif2b5 Eif2b4 Kcnq2 Eif2s2 Eef2k Eif2b1 Eif4h Eif1 Eif1ax Eif6 Eif4a2 Eif4a1 CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260910%WP513%RATTUS NORVEGICUS Catecholamine synthesis Ddc Pnmt Th Pah Dbh P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260910%WP656%RATTUS NORVEGICUS p53 signal pathway Bax Fas Tp53 Ccnb3 Gadd45g Gtse1 Ccne1 Bbc3 Siah1 Perp Parp1 Pmaip1 Cdk1 Rprm Igfbp3 Mdm2 Bid Igf1 Casp9 Casp3 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260910%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Gprc5b Gprc5a Casr Gprc5d Gprc5c Grm3 Grm2 Grm4 Grm7 Gabbr1 Grm6 Gabbr2 Grm1 Grm5 Grm8 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP1284%RATTUS NORVEGICUS EPO receptor signaling Map2k2 Map2k1 Akt1 Stat3 Pdk1 Sos1 Jak2 Raf1 Mapk1 Irs2 Epo Grb2 Src Rasa1 Mapk3 Ptprc Ptpru Stat5a Shc1 Stat5b Pik3cg TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260910%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Tgfa Tnfrsf1a Map2k1 Nfkbia Nfkb1 Chuk Rela Tradd Rps6ka2 Traf2 Tlr4 Egfr Il6 Sos1 Raf1 Mapk1 Grb2 Tnf Ikbkb Ripk2 Ikbkg Muc2 Shc1 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP40%RATTUS NORVEGICUS Inflammatory response pathway Il2ra Tnfrsf1a Il5 Il2rb Il2rg Cd40lg Cd40 Lamb1 Vtn Lamc1 Il2 Il4 Col1a2 Ifng Col1a1 Lama5 Lck Cd86 Il4r Tnfrsf1b Cd80 Il5ra Thbs1 Cxhxorf65 RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260910%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Tp53 Fth1 Anpep Txn Alox5 Casp3 Ftl1 Gsn Bax Abcc1 Fas Gstp1 Taldo1 Dffa Gss Dffb G6pdx Nqo1 Gpi Pgm2 Pfkl Eno1 Ugp2 Ugdh Pgm1 Pgam2 Nnt Ptgr1 Gclm Cdkn1a Map3k5 Kif1b Pgd Tfr2 Gapdh Tkt Gapdhl6 Rpe Dpep2 Rpia Ugt8 Pklr Ltc4s Mapk8 Tfrc Gck Aldoa Pgls Pgk1 WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260910%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Pparg Wnt3a PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260910%WP282%RATTUS NORVEGICUS Pentose phosphate pathway Pgls Kif1b Taldo1 Pgd Tkt Rpe Rpia G6pdx BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260910%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Map2k1 Raf1 Mapk1 Plat Plg Ntrk2 Serpine1 Ngfr Bdnf EBV LMP1 SIGNALING%WIKIPATHWAYS_20260910%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Nfkb1 Map3k7 Chuk Map3k14 Rela Tradd Ifnb1 Traf6 Mapk8 Mapk1 Pdlim7 Ccl5 Nfkb2 Ikbkb NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260910%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Adora2b P2ry6 Adora2a Lpar6 Adora1 P2ry2 P2ry1 Lpar4 PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260910%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Atp1a1 Fxyd4 Slc22a5 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1e1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Slc6a19 Slc7a6 Slc7a7 Atp1b1 Nherf1 Slc9a3 Slc9a8 Slc13a3 Slc34a1 Slc7a8 Atp6v1a Slc13a1 Slc7a9 Slc34a2 Slc13a2 Nherf2 Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Slc16a10 Atp6v1g1 Ca2 Ca4 Slc22a8 Atp6v1d Ca14 Atp6v1h Slc20a2 Slc22a6 Car15 Slc26a1 ID SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP397%RATTUS NORVEGICUS ID signaling pathway Nfkb1 Atf3 Psmd4 Rela Rbl2 Ccne1 Rbl1 Smad4 Rb1 Ngf Lck Id1 Elk1 Egf Cd40lg Elk4 Igf1r Srebf1 Myog Ccna2 Myod1 Id2 Id4 Tcf7l2 Bmp6 Pax2 Id3 Smad1 Pax8 Tert Smad5 Myf5 Kdr Hes1 Igf1 Bmp2 BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260910%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Pnpla2 Acsl1 Tpi1 Gpd2 Acsl3 Lpl Hadha Lipe Hadhb Dld Acadm Gcdh Crat Cpt2 Acads Acadvl Echs1 Cpt1a Lipf Acsl5 Acsl6 Acsl4 Acat1 Hadh HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Hhip Igf2 Gli1 Gli3 Gli2 Ski Shh Ptch2 Ptch1 Sufu Sap18 Dyrk1a Smo Cdk1 Crebbp Ccnb1 P53 PATHWAY%WIKIPATHWAYS_20260910%WP655%RATTUS NORVEGICUS p53 pathway Tp53 Tsc2 Ccne1 Cycs Siah1 Sesn1 Perp Chek2 Zmat3 Pmaip1 Cdk1 Rprm Serpinb5 Gadd45a Cdkn2a Shisa5 Sfnl1 Adgrb1 Cd82 Cdk6 Mdm4 Ppm1d Bid Rchy1 Tp73 Casp9 Chek1 Casp3 Pten Bax Fas Cdkn1a Serpine1 Ccng1 Igfbp3 Ccnb1 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Map2k1 Akt1 Il2rg Stat3 Vcp Jak1 Socs3 Mapk1 Irs2 Pik3r1 Grb2 Mapk3 Kat5 Ptpn11 Il9 Jak3 Il9r Stat5a Shc1 Stat5b Cxhxorf65 MRNA PROCESSING%WIKIPATHWAYS_20260910%WP529%RATTUS NORVEGICUS mRNA processing Celf1 Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Scamp3 Hnrnpa2b1 Supt5h Cdc40 Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Snrnp40 Prpf18 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Prmt1 Nudt21 Tmed10 Sfpq Prmt2 Cstf2 Dhx16 Cstf3 Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Srek1 Srsf10 Srrm1 Rbm17 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 Celf2 Pabpn1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260910%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Agtr2 Cysltr1 Ackr4 Gpr4 Gpr3 Ackr2 Gpr6 P2ry10 Or2ag1 P2ry12 P2ry14 F2rl1 Or10a4 Gpr50 F2rl2 Mas1 F2rl3 Adora2a Cxcr1 Ednra Ntsr1 Htr7 Fshr Htr2a Ccr5 Ccr2 Adra1d Cckbr Sstr2 Htr1f C5ar2 F2r Or3a1e Chrm3 Chrm2 Or2f1 Drd3 Gpr18 Grpr P2ry13 Gpr17 Adora2b Mtnr1a Cnr1 Cnr2 Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Ptafr Ptger3 Ptger1 Bdkrb2 Drd1 Drd4 Adra1a Htr2c Htr1a Adra2a Adra2c Adra2b Htr4 Chrm1 Hrh1 Htr6 Chrm5 Chrm4 Hrh2 Adrb1 Drd5 Adra1b Adrb3 Htr1d Ghsr Htr5a Cckar Ednrb Npy1r Npy5r Ntsr2 Brs3 Mc2r Oprd1 Cxcr4 Ccr7 Hcar1 Oprl1 Gpr161 Ccr6 Rrh Ccr3 Or3a1 Galr2 Or2h2 Galr3 Gpr65 Galr1 Or2h1 Npy4r Gpr68 Lhcgr Gpr63 Sstr5 Gpr173 Sstr4 Gpr174 Sstr3 Gpr171 Sstr1 Cmklr1 Avpr1b Olr226 Mc5r Oprm1 Gpr75 Tbxa2r Or7c70 Ffar3 Fpr1 Aplnr Fpr3 C3ar1 Nmbr Ffar1 Fpr2 Ffar2 Bdkrb1 Or2b2 Or2j3 Ccr10 Hrh3 Or5v1b Mc4r Gpr85 Or7a36 Oxtr Opn4 Npy2r Xcr1 Mc3r Lpar5 Oprk1 Opn3 Olr1073 Gpr19 Sucnr1 Or6b1 Gpr15 Or2c1 Or13c7d Gpr12 Adora3 Or2t1 Opn1sw Npbwr1 Nmur2 Prlhr Gpr25 Gpr27 Gpr22 Gpr21 Ccr9 Mchr1 Gpr37 Gpr39 Or11a4 Rgr Or14j1 Or10j27 P2ry6 Npffr1 Lpar6 Or2f2 Adora1 Npffr2 P2ry2 Ptgdr2 P2ry1 Rho Lpar4 Hcrtr1 Or5ap2b Or2w1 Gpr37l1 Gper1 Agtr1 Cysltr2 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260910%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Akt2 Akt1 Ptk2 Itgb1 Pak6 Capn1 Pak3 Capns1 Pak2 Vav3 Itgb4 Mapk7 Raf1 Itga2 Shc3 Capn9 Git2 Capn5 Capn7 Capn2 Vcl Bcar1 Rock1 Mapk10 Pdpk1 Rac2 Mylk2 Cav1 Tln1 Capn3 Vav2 Vasp Itga8 Itga6 Itga9 Itga3 Fyn Itga10 Crk Rock2 Sos1 Cav3 Braf Pik3r2 Cav2 Itgax Itgav Arhgef7 Itgam Itgae Itgal Mapk12 Itgad Itgb8 Shc1 Itgb6 Pak4 Selenop Itga2b Map2k2 Itgb5 Map2k1 Itgb2 Rapgef1 Capn6 Itgb3 Map2k6 Ilk Map2k3 Rac1 Cdc42 Zyx Akt3 Mapk1 Grb2 Src Hras Mapk4 Pxn Dock1 Rho Pak1 Itga1 Rap1a Rap1b WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP375%RATTUS NORVEGICUS Wnt signaling pathway Akt1 Camk2b Prkcb Prkca Raf1 Rhoa Ppp2ca Wnt5a Cdh1 Tax1bp3 Skp1 Sfrp2 Jun Sfrp1 Sox9 Dkk1 Magi3 Axin1 Axin2 Ror2 Crybb2 Apc Csnk1d Sall1 Cdc25c Senp2 Lef1 Ruvbl1 Vangl2 Lrp6 Csnk1a1 Dab2 Prkcg Lrp5 Tfap2a Pax2 Dvl1 Wnt7a Brd7 Wnt4 Ctbp1 Wnt3 Ctbp2 Fzd2 Jup Btrc Fzd4 Dvl2 Map1b Nlk Fzd9 Fzd8 Dvl3 Ctnnbip1 Ankrd6 Bcl9 Tmem97 Dlg1 Dlg2 Dlg4 Tcf4 Hipk2 Gsk3b Ccnd1 Cul1 Csnk2a1 Cdk1 Mark2 Smad4 Csnk2b Nr5a1 Wnt2 Camk2a Map3k7 Arrb2 Rac1 Arrb1 Camk2g Tbp Mapk9 Camk2d Mapk8 Mapk1 Wnt3a Ctnnb1 Mapk3 Mapk8ip1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260910%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Cdk7 Tp53 Ccnb1 Ccna1 Ccne2 Necab3 Cdkn2b Ccnd1 Tfdp1 Cdkn2c Cldn5 Pcna Myt1 Atf6b Mcm7 Ccne1 Rbl1 Mcm4 Mcm6 Mcm2 Pole2 Pola2 Cdk1 Ccng2 Creb3l4 Gadd45a Creb3l1 Orc5 E2f5 Rpa3l1 Mdm2 Orc4 Orc6 Cdk6 Orc1 Orc3 Rb1 Rpa2 Mcm5 Wee1 E2f2 E2f3 E2f4 E2f6 Pole Cdkn1c E2f1 Cdkn1a Creb3 Mnat1 Cdkn1b Ccnh ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP654%RATTUS NORVEGICUS ATM signaling pathway Ccnd1 Necab3 Bax E2f1 Tp53 Cdkn1a Ccne1 Cycs Chek2 Brca1 Pmaip1 Cdk1 Rprm Gadd45a Sfnl1 Cdk6 Rb1 Bak1 Casp9 Casp3 Ccnb1 TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Pik3ca Akt2 Akt1 Nfkb1 Tollip Cd40 Rela Irf3 Irf7 Irf5 Fadd Pik3r1 Pik3r3 Tnf Jun Pik3cg Pik3cd Nfkbia Chuk Tlr4 Mapk10 Cxcl10 Il6 Fos Tab2 Cd14 Il1b Traf6 Pik3r2 Map2k7 Nfkb2 Cd86 Mapk13 Cd80 Il12b Il12a Ticam2 Map2k1 Lbp Ly96 Map3k7 Tlr1 Ifna4 Map2k6 Ifna1 Pik3r5 Tlr8 Spp1 Tlr7 Tlr6 Cxcl9 Ifnb1 Tlr5 Map2k3 Rac1 Tlr3 Tlr2 Cxcl11 Mapk14 Mapk9 Akt3 Ifnar1 Ccl4 Ripk1 Mapk8 Ccl3 Map2k4 Mapk1 Map3k8 Ccl5 Mapk3 Ikbkb Ikbkg PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260910%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Tbxas1 Ptgis Cyp11a1 Hsd11b1 Hsd11b2 Ednra Ptgds Pla2g4a Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Anxa1 Anxa8 Ptger3 Anxa6 Ptger1 Ednrb Prl S100a6 Scgb1a1 Edn1 Hpgd Anxa5 Anxa4 Anxa3 S100a10 Ptgs1 Ptgs2 OSTEOCLAST%WIKIPATHWAYS_20260910%WP489%RATTUS NORVEGICUS Osteoclast Ctsk Itgb3 Atp6v1e1 Spp1 Tnfsf11 Ifnb1 Slc9a1 Trpv5 Ifnar1 Zcchc2 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP520%RATTUS NORVEGICUS G13 signaling pathway Arhgdib Iqgap2 Ppp1cb Cfl2 Wasl Sh3rf1 Cit Cyfip1 Mybph Pip4k2a Pak3 Arhgef1 Rock2 Pik3r2 Tnk2 Rps6kb1 Diaph1 Pik3cd Limk1 Pkn1 Rock1 Rac1 Mapk10 Cdc42 Map3k4 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Acsl1 Scd1 Acsl3 Mecr Echdc3 Echdc1 Echdc2 Acaa2 Fasn Acacb Acaca Decr1 Acly Echs1 Pc Acsl5 Acsl6 Hadh ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260910%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Ache Pcyt1a Ahsg Pdha1 Chat Pemt GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260910%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Vipr1 Calcrl Glp1r Crhr2 Crhr1 Adgrl2 Adgrl3 Ghrhr Calcr Adgre5 Gipr Gcgr Adgre1 Sctr Adgrl4 Adcyap1r1 Adgrl1 Glp2r THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260910%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Atp1a1 Ca2 Ca4 Slc4a7 Slc12a1 Kcnq1 Slc9a2 Aqp1 Kcnk12 Slc12a7 Kcnj16 Clcnkb Clcnka Atp1b1 Slc9a3 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260910%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Nfkb1 Rela Gpx3 Gpx6 Msrb1 Selenow Jun Txnrd2 Selenop Rpl30 Selenok Nfe2l2 Selenbp1 Eefsec Crem Sp3 Selenof Sars2 Selenoi Sars1 Fabp1 Selenoo Selenos Dio1 Selenot Dio2 Dio3 Selenov Sephs1 Trnau1ap Fos HYPERTROPHY MODEL%WIKIPATHWAYS_20260910%WP442%RATTUS NORVEGICUS Hypertrophy model Zeb1 Dusp14l1 Eif4e Ifrd1 Atf3 Ccn1 Nr4a3 Myog Il1a Il1r1 Eif4ebp1 Jund Ifng Ankrd1 Hbegf Wdr1 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Pik3ca Akt1 Nfkb1 Ptk2b Stat3 Rela Ybx1 Raf1 Socs3 Pik3r1 Rack1 Gab2 Lck Rps6kb1 Pik3cg Prkcz Pik3cd Chuk Nr3c1 Eif3b Il2 Ets2 Tert Foxo3 Stat5a Stat5b Eif4e Stam2 Cd53 Itm2b Stam Nmi Ptpn6 Fyn Crk Lyn Sos1 Pik3r2 Mtor Ptpn11 Jak3 Syk Shc1 Cxhxorf65 Il2ra Map2k1 Il2rg Plcb1 Mapk14 Mapk9 Mapkapk2 Jak2 Mapk8 Jak1 Mapk1 Irs2 Mknk1 Grb2 Mapk3 Crkl ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260910%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Agtr2 Akt2 Akt1 Agtr1b Calm3 Calm2 Gnaq Pde2a Agtrap Nox4 Mas1 Itpr3 Prkca Itpr2 Itpr1 Nos3 Dnm1 Pten Arrb2 Prkcg Akt3 Pdpk1 Prkaca Plcg2 Plcg1 Agtr1 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260910%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Nat1 Nat2 Ephx2 Gal3st4 Gal3st3 Inmt Nat9 Hnmt Gstk1 Cyp2e1 Chst11 Cyp2f2 Cyp7b1 Gstm5 Gstm4 Cyp26b1 Akr1a1 Gsto1 Cyp26a1 Gstp1 Cyp27b1 Gss Fmo1 Akr1b10 Cyp8b1 Cyp24a1 Cyp7a1 Sult1e1 Gstm1 Comt Sult1a1 Cyp1a1 Cyp1b1 Chst10 Chst12 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Ugt2b1 Sult6b2 Naa40 Nat10 Ndst1 Cyp4x1 Ndst3 Hs3st3a1 Sult4a1 Chst1 Sult2a1 Chst3 Sult2a6 Chst4 Chst6 Chst9 Akr1c1 Akr1b1 Zfp628 Gstz1 Hs3st2 Sult1b1 Hs3st5 Hs3st6 Cyp2s1 Hs3st3b1 Gstm7 Cyp4f39 Baat Naa20 Akr1d1 Gstcd Kcnab2 Cyp51a1 Kcnab3 Akr7a3 Mgst1 Hs2st1 Akr7a2 Tpmt Cyp21a1 Cyp17a1 Glyat Fmo3 Ephx1 Fmo2 Fmo5 Hs6st3 Fmo4 Hs6st1 Sult2b1 Naa50 Cyp26c1 Cyp46a1 Nat8 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260910%WP73%RATTUS NORVEGICUS G protein signaling pathways Prkce Prkd3 Pde7b Pde7a Akap7 Adcy8 Akap3 Prkcq Akap4 Arhgef1 Akap1 Gnaz Akap10 Prkci Slc9a1 Akap11 Prkcb Akap12 Prkcd Akap9 Prkca Akap13 Itpr1 Pde8a Pde8b Rhoa Kcnj3 Pakap Gna14 Gnao1 Gnal Gng5 Gna13 Pde4c Gnas Pde1c Pde1a Gng11 Prkcz Prkcg Nras Rras Ppp3cc Prkar1b Ppp3ca Gnaq Gngt1 Gnb2 Gnb1 Akap8 Gnb3 Gng13 Prkacb Adcy3 Adcy4 Gna12 Adcy2 Adcy7 Adcy5 Adcy9 Plcb3 Pde4b Prkar1a Gng3 Gnai1 Gnai3 Hras Pde4d Gng8 Prkar2b Prkaca WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260910%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Tp53 Prkce Ppp2r3a Prkcq Ppp2r2c Ppp2r2b Prkci Prkcb Ppp2cb Prkcd Prkca Rhoa Ppp2r2a Ptpa Ppp2ca Ppp2r1a Wnt5a Fosl1 Jun Wnt5b Pafah1b1 Axin1 Prkcz Sox2 Axin2 Wnt9b Fbxw2 Apc Wnt11 Tcf7 Nkd2 Wnt6 Lef1 Tcf7l1 Cd44 Pou5f1 Lrp6 Fzd3 Nanog Mapk10 Ppm1j Lrp5 Dvl1 Wnt7a Wnt4 Ctbp1 Wnt3 Ctbp2 Fzd2 Fzd4 Dvl2 Nlk Fzd9 Fzd8 Dvl3 Tmem97 Gsk3b Ccnd1 Ppard Ccnd2 Crebbp Wnt2 Map3k7 Mapk9 Wnt3a Plau Ctnnb1 MISMATCH REPAIR%WIKIPATHWAYS_20260910%WP1295%RATTUS NORVEGICUS Mismatch repair Pcna Pold1 Lig1 Msh2 Rfc1 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260910%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Scnn1b Scnn1g Cftr Nherf1 POLYOL PATHWAY%WIKIPATHWAYS_20260910%WP1303%RATTUS NORVEGICUS Polyol pathway Aldob Akr1b1 Sord Khk}