TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME DATABASE ID RELEASE 97%10229202 Transport of nucleotide sugars 311204 306866 310808 313139 296969 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-RNO-8939247.1 RUNX1 regulates transcription of genes involved in interleukin signaling 50662 361391 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-RNO-975155.1 MyD88 dependent cascade initiated on endosome 64156 25742 81647 116725 314322 311245 315648 363328 309452 309295 81771 310877 117269 500133 60350 363520 29260 293624 291921 64044 300447 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 448830 25493 312688 116663 54226 309361 60587 303024 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%10228146 Activation of the pre-replicative complex 312046 313138 313479 299112 298098 292071 362385 312538 291927 307126 360621 304573 362304 301430 85241 360908 301323 288532 316273 59102 295596 296178 29728 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling 64199 24654 286924 83506 24611 79218 360616 24627 24626 25638 81636 245986 25238 24668 60449 25031 293508 302950 85240 294962 64532 25521 25686 25289 25643 25601 25725 83579 29241 680149 84420 58979 140908 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 315648 24680 81662 81664 60341 29691 363193 24673 24672 117281 116590 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-RNO-2468052.1 Establishment of Sister Chromatid Cohesion 290577 304218 313304 680014 63996 684771 691979 305343 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 97%10231498 Class I peroxisomal membrane protein import 116718 64460 310682 83519 25270 297570 363516 311203 305581 29534 84356 307170 282634 29533 65183 288584 309532 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%10228956 Post-translational modification: synthesis of GPI-anchored proteins 113910 81506 316400 353304 29640 681033 296394 79112 29561 502017 116597 60378 362133 50692 60333 117522 541462 362934 363104 367308 300027 64621 295543 116658 59318 59313 690037 50864 312806 192263 691120 100910143 25586 24257 114589 311169 81613 29142 83834 415062 353251 54279 691259 309659 315807 366478 307992 362756 303277 288038 363060 364032 304966 378774 207113 681194 313488 117054 288041 314180 300017 300653 287159 315075 292666 360838 100359675 293154 291132 24832 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%10228346 Pyrophosphate hydrolysis 310856 361663 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-110362.1 POLB-Dependent Long Patch Base Excision Repair 362600 290027 84490 25591 79116 29240 83507 CAM PATHWAY%REACTOME%R-RNO-111997.1 CaM pathway 302950 64532 25521 25289 25725 29241 84420 24244 170538 83506 64508 81742 25050 81636 24681 29699 25238 24680 60341 29691 293508 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-RNO-8981373.1 Intestinal hexose absorption 65197 25552 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-RNO-9909648.1 Regulation of PD-L1(CD274) expression 289874 287772 292766 94201 290783 65248 29669 29668 362040 56010 29425 64156 100360846 116967 83712 117263 25581 29666 81650 315606 303353 365388 290829 58919 290823 302783 117262 85492 192275 407784 64562 24829 306945 287984 24828 65138 362093 313048 94198 29673 50522 100188932 29671 29670 117056 29677 680498 29676 29675 116643 685909 680615 309304 192255 290638 365877 686092 301626 81827 25520 116549 83803 287280 83806 311078 84027 313648 362891 361765 303175 373545 688041 363160 100912032 301555 499342 287643 64701 64627 690315 690795 360967 304794 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-RNO-419408.1 Lysosphingolipid and LPA receptors 66025 306792 298062 60399 310812 116744 29415 29733 500317 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-RNO-629587.1 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 25590 29422 25103 54239 25753 54240 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-RNO-375165.1 NCAM signaling for neurite out-growth 24605 289257 293621 305614 64159 306628 116590 24586 314251 81504 24525 25614 25150 50689 116696 313845 117523 308458 290905 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%10230950 ARL13B-mediated ciliary trafficking of INPP5E 363272 114089 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%10228278 Respiratory electron transport 288740 25309 292845 298748 293655 81728 291671 293453 298147 691506 293130 497902 299310 26195 499529 26194 171335 686506 654441 26199 303393 361385 26198 681896 84683 497863 681418 301011 26193 26192 289522 301458 300047 296658 64201 301416 317444 297821 102550385 26203 26202 94194 300726 688386 681024 362322 100188937 26201 300447 362440 54322 360826 360229 366448 303922 289218 293114 304735 301427 25488 293991 25721 81829 313450 64539 25282 361520 309111 120097699 29445 362495 24551 296190 362810 293448 678759 294973 291103 100912357 315167 24401 295143 362588 296086 361894 685322 102555170 690675 690354 301123 56769 252934 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-RNO-381070.1 IRE1alpha activates chaperones 498013 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%10228504 RNA Polymerase II Promoter Escape 170844 83830 171152 309638 289561 292778 288651 288533 373541 293345 294018 361580 303918 117526 294693 83503 117017 291703 498109 363633 287571 288588 266713 291773 316123 317256 502227 83828 690966 361365 81673 84389 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230018 Sphingolipid de novo biosynthesis 361213 314438 100270678 310667 500651 170897 366697 366984 307855 310849 360833 308589 304208 353229 499174 366065 360618 500624 312382 58970 24565 296188 80773 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-RNO-3928663.1 EPHA-mediated growth cone collapse 25150 81515 117273 83805 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-RNO-202430.1 Translocation of ZAP-70 to Immunological synapse 294269 300678 313050 25300 24981 25710 24986 24932 295338 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-RNO-9732724.1 IFNG signaling activates MAPKs 50689 360697 24703 116465 25712 116590 24514 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229990 Metal ion SLC transporters 305846 295455 311651 58976 170840 171135 192215 314637 316519 117240 361986 363985 56814 25715 306009 294698 314396 24784 24783 29715 311387 362861 294281 24782 84550 299903 140447 300051 85267 140448 289353 363115 24244 291733 317170 498185 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-RNO-392154.1 Nitric oxide stimulates guanylate cyclase 140928 63885 25523 24599 24598 24600 81743 171115 25262 54286 191569 308899 29691 THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome 304987 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%10229072 Signaling by Interleukins 81504 25150 313845 81515 313050 64156 25742 24932 81647 116725 314322 311245 315648 24514 309452 309295 81771 310877 117269 500133 363520 291921 64044 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 113894 100912032 25466 317546 24498 81736 25467 29144 25493 689932 312688 24493 116663 690369 54226 361749 309361 100911249 60587 688621 303024 54245 24918 303604 25325 25326 54259 116470 24803 65038 290257 314870 25578 25216 29376 362862 362629 362628 317553 117022 362077 498951 155140 287942 25556 500836 310132 84477 25670 361677 171081 313173 25402 500985 296541 25084 688622 29201 84388 365368 287287 373540 500616 89829 299827 84492 680609 25506 85491 25622 25746 301059 25513 311783 85243 81680 681112 116630 290655 25613 25734 444986 685840 682457 60664 85385 25704 25707 100361294 116689 81802 81803 81804 84405 171334 171333 245983 116558 304091 116562 29197 170911 25155 50646 300177 25125 25126 365769 116553 499744 289747 170819 366508 171106 25012 60582 301365 287772 292766 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 680498 29676 29675 81827 83806 311078 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 97%10230972 Activation of SMO 25273 113927 25238 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%10231750 Degradation of CRY and PER proteins 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 63840 78962 192255 287422 81827 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%10229674 Breakdown of the nuclear lamina 116685 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-RNO-432722.1 Golgi Associated Vesicle Biogenesis 310746 363476 306332 29292 192243 294900 288785 364183 289312 295217 64310 64678 116743 317630 85491 100362805 25306 89816 83730 83576 140673 25387 313409 192152 25319 362609 689256 25751 296199 312694 81659 24468 287709 361632 83800 641528 295171 54241 25151 24803 683687 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10228806 Platelet calcium homeostasis 81739 29659 116601 114115 25262 113995 25679 25505 25391 81678 29693 25041 24244 29600 29665 29599 29715 29598 60395 140447 140448 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-RNO-2562578.1 TRIF-mediated programmed cell death 448830 60350 246240 29260 266610 306886 64044 363328 364867 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%10228780 Thrombin signalling through proteinase activated receptors (PARs) 294962 83579 116590 680149 25387 83805 58979 64199 50689 114117 24400 79218 81666 25388 81667 29636 245986 116498 81662 60449 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling 65038 116562 170911 25746 25513 85243 81504 116630 84477 366508 313845 171081 60664 85385 25704 116689 25326 24514 54259 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%10229690 ABC-family protein mediated transport 114628 302973 24255 24565 116721 170924 25303 24891 54318 85493 286970 303639 287788 79248 81642 302395 289874 299609 287772 296302 292766 63886 314537 83535 25560 29669 25081 29668 300664 362302 299027 29425 301482 64156 100360846 155192 140668 140669 117263 25581 29666 303353 365388 290823 117262 85492 407784 287984 83519 65138 25270 363516 94198 29673 50522 29671 84356 29670 29677 29676 29675 116643 192255 81827 83806 311078 362891 100912032 690315 360967 MEMBRANE TRAFFICKING%REACTOME%R-RNO-199991.1 Membrane Trafficking 289257 305614 64159 314251 81504 308458 83805 300678 25710 24932 24803 500985 85491 81803 294900 288785 364183 289312 295217 64310 64678 116743 317630 100362805 25306 89816 83730 83576 140673 25387 313409 192152 25319 362609 689256 25751 296199 312694 81659 24468 287709 361632 83800 641528 295171 54241 25151 683687 310746 363476 306332 29292 192243 25388 24255 64154 288700 365793 362283 500249 362162 361073 54350 315059 81732 363123 310839 24825 24827 65134 306229 113886 297428 287624 24942 120097389 304290 58842 363136 287873 363273 294286 299850 246294 81754 79434 81756 29489 58974 363266 366896 140932 289820 65277 24805 64187 24807 64189 363283 317580 287645 316017 252853 171549 192348 311911 140940 29491 311919 65165 296649 65046 307868 316226 685144 29585 29584 81655 79214 29586 79217 690961 366311 363288 65178 266707 124461 116717 266706 687208 81645 363059 297518 365372 360915 29448 297995 295333 79117 29564 308942 303251 252889 304344 93646 314030 297522 29216 295461 114638 294010 292074 299825 309922 64670 289994 288669 64558 501854 114590 299799 114113 85256 290746 292925 290635 360827 290994 361916 94193 298598 94197 85248 54400 84393 287110 171121 290639 292944 313493 313254 315668 360956 360953 303575 290775 24648 287367 64462 314473 289309 266606 314349 89868 290659 691042 64351 300158 81922 313474 24855 313234 365191 116692 116691 312257 171575 681059 361705 498798 360854 499768 171574 171452 29183 192154 301012 25716 24506 24505 287427 310097 116561 81921 683007 116563 114023 302470 304978 116666 117513 100360302 311030 81824 81830 207119 29167 140734 58817 300147 64022 288779 303659 313340 306809 315999 58945 315756 54225 501550 360768 292886 292760 311494 25108 314641 29704 282834 117103 60355 361987 294709 293502 315740 25233 50563 50564 690252 360426 367073 84589 360797 266688 303734 100912115 64862 117548 299075 25218 315840 117550 360202 362983 312689 60384 289397 362502 300674 64630 300438 64633 291990 25423 64516 299121 140670 50592 309010 246310 117028 361308 363720 171291 25433 25313 64528 361555 171049 64156 309144 84357 84599 24221 171041 84590 287275 287276 25407 94189 140694 680465 246772 85238 361207 24329 292994 25532 25531 117106 25655 361577 361697 84379 25530 84018 289350 361459 50522 293456 25183 29662 309451 252902 108348178 307039 361227 300888 286932 293344 192255 246117 685079 79120 79121 261736 79128 364981 252916 117051 294324 246324 29528 246209 310411 361244 29885 361120 309798 100912032 309678 300743 394266 56042 29414 296750 54226 311880 497913 367915 60668 117277 313934 60422 117039 314906 363677 317396 689102 362237 362599 306264 364419 503165 84403 59325 362118 363326 289168 60568 24185 311854 60566 60445 29753 29631 60564 60562 50645 24180 500906 252929 353302 24392 366618 84428 25238 83572 679886 363466 56084 25490 25372 363235 309523 100359675 367308 64621 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-RNO-8849468.1 PTK6 Regulates Proteins Involved in RNA Processing 366275 117268 170843 64015 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 97%10229308 Cellular hexose transport 85256 303205 64522 25552 25551 304785 501925 295245 25139 294341 24778 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 97%10231112 Major pathway of rRNA processing in the nucleolus and cytosol 291317 291434 81729 25347 29304 25348 28298 313707 305258 65136 360828 27139 64205 26962 64462 289809 313167 294282 310720 300092 100910714 363134 362967 681429 117053 100362640 64298 161477 289810 290641 296865 192180 359727 303608 94266 362214 360552 305076 314617 310019 315705 140654 85432 140655 60373 366017 361923 134480579 102551819 117042 287120 287122 291987 499782 294975 103689992 297685 291061 140661 29258 140662 29257 362902 362229 300079 291996 292964 293418 317399 290660 291071 81768 100361974 81775 81776 314713 362631 679140 313744 360574 360572 81773 81774 361262 245981 497860 81770 300045 308201 290556 691531 64640 83789 361159 81764 686999 81765 81766 122799 114021 81767 29236 81763 312706 300050 690297 100361060 309301 58927 293828 292747 689284 288647 100361756 100360664 368084 29288 29287 29286 29285 316317 124323 307850 29284 29283 29282 296709 289740 64302 64306 314830 100360439 64307 58822 64156 298065 314545 122772 361452 134486107 362703 361977 363237 362426 50522 NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism 287830 291874 362281 113975 685068 499391 292085 295692 117021 362335 84404 687711 363462 366016 58958 691231 65160 362557 65274 113929 297522 100362099 64301 681031 245922 81738 362688 683983 53372 316108 25497 310769 499974 84473 312947 171365 680737 294429 291794 REGULATION OF TP53 EXPRESSION%REACTOME%R-RNO-6804754.1 Regulation of TP53 Expression 24842 MTORC1-MEDIATED SIGNALLING%REACTOME%R-RNO-166208.1 mTORC1-mediated signalling 25639 292887 308869 310091 298514 64226 295357 116636 25435 297960 26954 117044 117043 117045 83840 29304 362045 56718 360776 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%10228362 Cap-dependent Translation Initiation 682390 298700 64514 691947 299872 293427 288599 303831 288516 299899 171350 308306 291434 81729 25347 29304 25348 28298 65136 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 81773 81774 245981 497860 81770 691531 64640 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 54318 29288 29287 29286 29285 124323 29284 296302 29283 29282 296709 64302 64306 100360439 64307 299027 64156 122772 134486107 50522 116636 117045 292762 362952 192234 108348073 292148 300069 293484 171145 117019 GPCR LIGAND BINDING%REACTOME%R-RNO-500792.1 GPCR ligand binding 81645 287730 24816 24938 25107 25229 688605 689936 316019 29385 246075 379044 282832 25340 554302 50672 25342 29141 60590 292409 58959 64042 53949 308408 25477 294394 246759 58965 29397 24260 58966 25593 25111 292419 29151 24476 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25329 25449 81753 29363 54258 500157 84348 25321 24232 81752 24473 305236 50577 289023 171551 65032 24925 24806 24808 24929 290493 292794 117549 24247 316259 295144 316137 192223 317219 25570 81503 24241 29256 498289 362505 100360071 497196 100911796 497078 25542 24695 64636 302619 81648 299242 117264 57305 81657 353250 308163 84007 24694 117027 57302 89810 100270683 360579 29581 171056 365228 306307 25555 29238 89808 81644 689869 29595 29237 25108 192205 29235 192206 170634 29597 29234 84475 29471 171044 24318 102552838 360918 294123 116700 314386 171519 24797 294124 685243 24677 25524 25645 294121 25083 114098 114099 29446 81672 25087 84023 399475 294807 25653 25652 24323 24326 81779 24448 81668 29335 301086 690158 367315 24418 24659 266997 24417 24419 24772 114105 24414 60628 24416 25504 24415 445269 309212 24221 25187 83633 78964 500091 171371 494319 497942 56813 117064 64680 498475 192648 192649 246358 29316 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 56820 310444 25075 25195 29555 192646 310327 501177 500089 100310876 301066 25726 25605 113914 679957 287910 298006 116506 25723 24875 29407 25040 78981 78980 171158 78983 362454 78985 498335 117041 25616 366270 24769 366274 29538 117029 54226 245920 83518 24889 246219 266607 60669 25051 60665 29413 29412 78976 25298 679975 54305 85268 78979 302378 25706 25026 170926 24179 259224 259222 25029 24613 25380 64199 25264 24174 690448 24175 25024 79218 60432 24180 25265 361383 363682 29180 288995 378939 245986 498791 691774 116677 60449 319107 64803 319105 24182 294962 25033 29191 287673 499194 113959 24717 25601 25245 25369 63843 83579 25248 680149 170704 117518 58979 24953 25007 260319 60337 680188 114117 24400 25360 58812 287561 287562 24604 81667 63850 502757 171104 171108 500101 83567 24166 310869 29290 171101 58949 29636 116498 24807 66025 306792 298062 60399 310812 116744 29415 29733 500317 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%10230714 Nuclear Envelope Breakdown 287830 291874 362281 25203 113975 316737 54237 292085 25023 295692 287447 117021 25437 362335 25515 114087 299204 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 116685 25497 499974 24680 294429 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 97%10228984 Transcription from mitochondrial promoters 289307 83474 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 97%10230566 Signaling by NOTCH1 50522 64156 192255 100912032 304591 311567 SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes 292767 366174 680264 689349 100910102 680912 290989 362623 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231572 RND2 GTPase cycle 65183 302855 291755 301007 29648 293497 363009 116478 362938 362859 315829 303553 361029 64678 306400 287543 366492 289229 306506 360849 192348 498331 310074 25513 312077 316213 314850 299012 312667 192207 305645 140922 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME%R-RNO-9938027.1 Affinity selection of immunoglobulins 309812 24984 294273 316235 81685 288003 290644 293502 116468 315740 29448 81709 289168 50654 399679 25737 29564 294339 288414 25697 29175 305000 353302 294010 117550 84428 25423 299121 361308 85248 84393 294269 24981 64156 24986 171041 314473 287624 50522 299850 252902 29489 192255 171549 29167 100912032 140734 316226 287531 289758 316344 81655 25424 58945 296320 259221 25425 89809 313702 314906 365542 684529 361704 FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229078 FCERI mediated MAPK activation 24605 293621 25155 363855 81504 24525 25272 295378 50689 81511 24516 313845 100360919 25738 29337 29431 116667 29432 366962 363875 116554 50658 116590 81515 85385 314322 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%10231606 Atorvastatin ADME 25303 58978 140860 266682 84024 312086 252931 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism 24192 361730 684314 24188 24788 25659 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 97%10228718 GPER1 signaling 25521 24511 85385 25725 29699 293508 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229324 FGFR2c ligand binding and activation 66017 25444 29349 54250 25317 29369 25022 29368 170700 116499 60662 60464 170583 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-RNO-5654712.1 FRS-mediated FGFR4 signaling 24605 66017 293621 25444 25622 29349 54250 25317 29369 316213 81504 314850 29368 24525 170700 116499 60464 313845 170583 289625 25114 170582 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-RNO-1679131.1 Trafficking and processing of endosomal TLR 362862 63865 684440 50654 361689 317468 25697 29175 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229844 PD-1 signaling 25622 289874 287772 292766 94201 290783 65248 294269 29669 300678 29668 362040 313050 25300 56010 29425 24981 64156 100360846 25710 116967 24986 24932 83712 117263 25581 29666 81650 315707 116689 315606 303353 365388 290829 58919 290823 302783 117262 85492 192275 407784 64562 24829 306945 287984 24828 65138 362093 313048 94198 29673 50522 100188932 29671 29670 117056 29677 680498 29676 29675 116643 685909 680615 309304 192255 290638 365877 686092 301626 81827 25520 116549 83803 287280 83806 311078 84027 313648 362891 361765 303175 373545 688041 363160 100912032 301555 499342 287643 64701 64627 690315 690795 360967 304794 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229322 FGFR1c ligand binding and activation 66017 25444 29349 54250 25317 29368 170700 116499 60662 170583 79114 83823 29610 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-RNO-72764.1 Eukaryotic Translation Termination 24206 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 97%10231362 OAS antiviral response 306231 359726 304545 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%10230810 EPH-Ephrin signaling 297518 293621 25614 25150 295378 29431 29432 363875 288669 81515 117273 83805 81732 24410 83709 686310 24338 84009 316539 300802 287989 25676 312275 81687 116683 310643 29433 84358 81686 360854 29192 79208 360546 171287 292788 94268 306636 298528 287876 316369 312279 289820 361882 501203 81751 304109 24408 64465 114559 25615 366492 25537 29210 81822 83841 81824 54227 289231 29491 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-RNO-5693532.1 DNA Double-Strand Break Repair 316794 498749 171366 171525 299112 85482 298098 289777 287634 362385 192218 114212 290805 361767 304573 293489 298534 287927 685055 310034 297561 25573 313539 308755 361815 306734 301442 499417 301128 300711 299638 302982 690043 302502 288079 297627 65179 292172 59294 311860 296099 295052 360748 360588 497856 302953 64012 499870 294800 293678 498265 368002 314380 29722 114494 498411 308669 100359714 293719 291787 289468 259171 361181 100361529 689055 25019 297486 361698 140583 362827 84495 362704 306257 289758 89809 316235 288003 116468 25737 288414 305000 290027 84490 25591 287772 292766 29669 29668 29425 64156 100360846 116725 117263 25581 29666 303353 365388 117262 85492 24829 306945 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 116554 24842 83806 311078 303175 289757 363251 100912032 497672 293452 64557 156826 304719 64627 83508 363924 102551085 303194 315969 290907 363247 498119 499966 290997 59102 64046 290631 502935 P2Y RECEPTORS%REACTOME%R-RNO-417957.1 P2Y receptors 310444 29597 25265 302378 317219 117264 767613 63843 171108 691774 64803 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-RNO-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 170824 140923 134478826 300711 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 97%10228366 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 682390 81773 298700 81774 691947 299872 293427 288599 303831 288516 691531 299899 171350 83789 122799 29236 100361756 54318 29288 29287 29286 29285 124323 29284 296302 299027 29304 64156 25348 122772 65136 27139 294282 681429 117053 100362640 161477 94266 140654 140655 103689992 29258 116636 117045 292762 362952 81775 81776 292148 300069 293484 PI-3K CASCADE:FGFR2%REACTOME%R-RNO-5654695.1 PI-3K cascade:FGFR2 66017 25444 25443 25622 170911 29349 29348 54250 361388 25513 25317 170579 29369 170633 25022 81504 314850 29368 170700 116499 60662 60464 170583 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229542 Disassembly of the destruction complex and recruitment of AXIN to the membrane 24672 84027 117281 303811 291678 303251 64512 317674 24205 309179 299147 79257 363193 312754 24881 83721 24673 501584 113927 84353 103691373 315648 679110 SIGNALING BY BMP%REACTOME%R-RNO-201451.1 Signaling by BMP 290921 25366 79210 81507 29200 499508 59328 29263 85435 50554 310914 289264 367100 25378 25237 81516 24504 140590 29530 690516 81920 29373 25671 500245 313757 500485 363455 361831 29610 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231156 Negative regulation of MET activity 81921 116743 81922 313474 311030 100912032 81504 50522 498798 64156 84357 24553 500985 24697 24446 312574 296121 192255 117063 56084 SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 97%10230086 Signaling by Hedgehog 289711 289712 287612 59320 65209 311324 499241 304729 296532 84399 307724 361712 308577 100362124 84380 305349 303968 295654 289180 116475 364475 361769 89830 691171 50938 81636 312651 503018 25238 362265 29499 140588 140589 293508 302950 64532 25521 25506 25289 25725 289874 287772 29241 292766 84420 29669 29668 29425 64508 64156 100360846 117263 25581 29666 29699 303353 365388 117262 85492 287984 65138 311567 94198 29673 50522 29671 29670 29677 29676 25273 29675 113927 116643 192255 81827 287280 83806 311078 84027 362891 361765 100912032 301555 690516 287643 303743 304832 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-RNO-264870.1 Caspase-mediated cleavage of cytoskeletal proteins 64026 296654 81818 25402 64044 64159 24170 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-RNO-209931.1 Serotonin and melatonin biosynthesis 24848 25120 24311 317675 246281 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231620 Negative Regulation of CDH1 Gene Transcription 302783 25705 24829 306945 81717 500569 303175 24828 689820 688041 297893 290270 313048 85489 309757 29382 64627 117056 690795 680498 83712 685909 680615 365877 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230622 Abacavir transmembrane transport 24904 29504 29503 TRKA ACTIVATION BY NGF%REACTOME%R-RNO-187042.1 TRKA activation by NGF 59109 310738 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%10229364 Regulation of gap junction activity 292994 24392 83805 PURINE SALVAGE%REACTOME DATABASE ID RELEASE 97%10228436 Purine salvage 25368 292072 25095 362015 290029 192357 79127 24165 117533 24465 25028 297389 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 97%10231034 TNFs bind their physiological receptors 353218 302424 365581 156767 25069 117516 296872 25008 25625 683163 500592 25572 25341 89814 498666 500590 498769 252878 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10230766 WNT ligand biogenesis and trafficking 303586 291678 289883 315294 288666 24881 287357 684097 84426 316526 140584 362065 114850 114487 361846 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 97%10230608 MHC class II antigen presentation 24984 294273 306332 290644 293502 315740 29448 289168 50654 29564 25697 29175 93646 297522 295461 353302 294010 117550 84428 25423 299121 140670 361308 85248 84393 294269 24981 24986 63865 171041 287275 287276 314473 140694 287624 299850 252902 171574 29489 25599 116563 297596 64310 116743 171549 29167 140734 58817 65046 29144 316226 685144 25751 287531 81655 25424 58945 259221 25425 83800 314906 365542 54241 684529 361704 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI 362039 691905 29354 24913 29692 308309 295631 298579 29526 29359 297694 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling 83709 114559 686310 24338 83841 287989 312275 83805 29433 25150 360546 29431 29432 306636 363875 316369 501203 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors 25682 58851 307096 246332 363026 363425 266603 59325 24605 192218 266686 293621 64466 308190 25335 81745 24185 60421 84578 301164 24525 361810 25614 304157 286924 289950 298942 25149 81654 24172 361266 81530 301128 89813 362110 353252 301252 364773 294515 498790 25718 65179 362809 260321 117098 25154 170635 25686 498789 365755 302711 25643 500629 25522 313210 25513 29563 313689 171516 116676 84424 24244 83571 83574 361967 85471 297805 312495 60349 60664 298184 85385 25098 171068 140868 191574 81664 170911 29183 64022 288588 316123 83828 690966 361365 83830 289561 292778 25233 117526 83503 117017 498109 363633 24188 170897 500569 297893 83805 25433 25313 50662 361391 81647 314322 302783 24329 24827 24829 306945 24828 81687 50689 81686 24516 117056 680498 685909 680615 365877 24600 303175 116590 296849 311254 25061 311764 24890 29414 64627 29149 497941 690795 85252 24705 500633 685072 306792 685750 299331 291283 360420 24919 307092 170906 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%10228706 DAG and IP3 signaling 302950 64532 25521 25289 25725 29241 84420 24244 170538 83506 64508 81742 25050 81636 24681 29699 25238 24680 29340 60341 29691 293508 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-RNO-8877330.1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 50662 361391 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-RNO-193648.1 NRAGE signals death through JNK 317598 298404 287537 287418 310460 64639 307098 84009 120099896 246174 311647 363509 310635 310999 78966 140898 361921 307398 295378 309653 117020 313845 303634 301334 295449 363460 310192 64547 114513 363875 293024 100362710 687105 362648 304109 116554 114559 29491 306618 66013 500608 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%10228168 Removal of the Flap Intermediate 59294 84490 289758 301323 25737 59102 85241 361698 FATTY ACIDS%REACTOME DATABASE ID RELEASE 97%10228548 Fatty acids 266674 24894 24299 502969 298423 24895 286904 313375 24306 171522 299566 503122 54246 171178 50549 24307 290623 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%10230196 Keratan sulfate keratin metabolism 314771 316033 292073 64507 313536 500961 494342 362924 81682 58968 65196 299825 290638 295934 300757 291015 301525 303923 316583 305571 84400 362275 84468 363040 64442 64445 293667 367145 307859 294673 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 97%10230956 RHO GTPases activate IQGAPs 24244 64465 84353 363875 83502 310621 65201 100360623 29417 ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 97%10229376 Endogenous sterols 25429 266761 301517 25426 25428 79122 25427 29189 313786 83724 25242 362782 25243 60351 29680 498999 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229048 MyD88 cascade initiated on plasma membrane 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 97%10229764 Degradation of the extracellular matrix 290257 58968 50654 25335 83502 25697 29175 25627 65164 315174 66015 65205 170808 24291 83513 116694 57025 24691 29268 29543 306260 685612 117061 85253 499285 304608 304802 63834 315388 54281 29156 29155 29154 29153 25393 25353 303000 299606 683849 291848 304135 499431 300338 25246 81707 25403 25406 25481 24153 103690254 116510 100169747 81687 306404 300341 408218 29139 117033 81686 362347 63849 29650 25052 83685 308476 362701 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 97%10230776 Regulation by c-FLIP 266610 306886 64044 246097 117279 25385 246756 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%10228710 DARPP-32 events 24672 25521 117281 25725 140908 363193 360616 24627 24626 25638 24673 29699 315648 24668 293508 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228268 Amino acid and derivative metabolism 294972 25699 310152 685325 85309 311358 25331 306574 65151 246307 29221 117024 311446 79213 303272 64192 65162 290551 66029 288912 81522 29475 81640 25430 84596 29592 298607 24314 25085 24792 29443 89833 81670 497840 681319 266807 79462 29215 170898 79107 81660 362428 361215 364064 360816 64313 298227 294421 59085 79251 25502 29301 308129 308800 85254 171133 364975 64564 50719 64203 64206 299201 24661 56823 691966 24513 25044 171151 192172 681913 362322 306840 25618 298934 292710 304429 29416 25611 25612 315439 29531 365972 140547 303306 293779 296925 25721 100365773 81805 361272 312381 114027 689588 63938 311844 311849 360975 305177 290947 300723 289727 116682 83784 25274 301384 24957 24401 24399 29603 24398 81708 685999 170943 25244 300384 24609 25014 25256 59113 24962 192268 29611 114123 246266 25134 300035 116700 25653 24848 25120 24311 317675 246281 298942 287772 292766 29669 29668 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 100169747 94198 29673 29671 29670 29677 29676 29675 302899 24813 64037 63864 29700 81827 311374 58835 117100 24250 83806 50676 311078 309732 29383 306586 81718 29711 114613 367181 83586 24264 24265 50567 308652 361755 64040 81508 291450 100360621 293871 290484 170907 361884 50690 309150 363024 363285 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%10230708 Beta-catenin independent WNT signaling 365901 362550 306782 314212 100361818 282581 307401 24674 25400 24675 497961 364754 100360552 64303 303251 688319 64199 24525 50664 79218 25388 363875 245986 60449 64558 294962 140670 83579 287772 292766 680149 117273 58979 29669 24244 29668 114117 24400 29425 64156 100360846 117263 81667 25581 24681 29666 24680 303353 365388 117262 85492 25023 287984 313121 65138 303811 64512 94198 317674 29673 50522 29671 29670 29677 24881 29676 83721 29675 84353 84426 140584 192255 116561 81827 116563 83806 311078 100912032 690516 65046 83800 289878 161452 266715 54241 29748 688297 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%10228156 CDK-mediated phosphorylation and removal of Cdc6 117262 85492 287984 360621 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 362485 29675 305420 360643 192255 81827 83806 295052 311078 287772 292766 100912032 29669 29668 114494 29425 64156 100360846 361831 117263 25581 29666 303353 365388 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%10230930 BBSome-mediated cargo-targeting to cilium 500832 316102 295230 29374 299246 311456 362142 363760 171044 299809 361930 29885 25273 100910342 113948 24818 365770 83567 288305 294864 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-RNO-2534343.1 Interaction With Cumulus Cells And The Zona Pellucida 500052 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 97%10228560 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 140547 25287 113965 171155 170670 RAS PROCESSING%REACTOME DATABASE ID RELEASE 97%10231552 RAS processing 25523 24605 293621 65142 24525 64511 24244 302808 361171 25514 25318 170818 24888 363272 309399 309153 299617 361601 SWI SNF CHROMATIN REMODELERS%REACTOME%R-RNO-9932451.1 SWI SNF chromatin remodelers 368001 292622 296732 299186 83833 361374 361295 301020 361925 305589 361825 192352 361711 100359714 292404 287876 293514 301235 303518 297867 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation 66017 25444 25443 29349 29348 54250 25317 170579 29369 170633 64535 25022 29368 499349 170700 116499 60662 60464 170583 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling 29753 295378 313845 25402 363875 301059 117273 64156 310738 311245 306618 66013 500608 317598 298404 287537 287418 363520 310460 64639 307098 84009 120099896 246174 311647 300802 363509 310635 362491 310999 78966 140898 64314 361921 57027 307398 50522 84006 309653 117020 84351 24596 303634 29192 29409 301334 117089 295449 360678 363460 83765 292788 310192 450224 64547 362548 114513 293024 100362710 192255 687105 362648 81751 304109 116554 114559 289231 29491 113894 100912032 81736 25493 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%10231332 Receptor Mediated Mitophagy 116549 64862 360827 288731 362245 361321 81650 363442 365601 83805 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 97%10229580 Regulation of pyruvate dehydrogenase (PDH) complex 289950 117098 298942 81654 681913 81530 89813 296849 246311 54705 311254 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%10228616 Signaling by EGFR 24329 24827 59325 24605 81922 313474 293621 170911 361388 81504 24525 50522 498798 313845 25738 29183 500985 192255 56084 294981 81921 64019 315829 306141 500873 64465 301512 114559 116743 311598 117255 360820 25622 311030 25513 361120 100912032 83805 25433 64022 25313 64156 84357 117277 85385 315707 312574 SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 97%10230474 Synthesis of CL 366196 P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB 363520 301059 362491 113894 100912032 81736 50522 25493 84006 24596 84351 64156 310738 311245 192255 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-RNO-112315.1 Transmission across Chemical Synapses 116638 25590 29422 29718 25103 24380 54239 81721 25753 79246 54240 83589 58963 84556 50688 64053 65024 29647 298521 81632 79213 29483 79557 64199 60377 286924 54257 83506 29642 84347 24611 308868 79218 29482 117284 497009 24407 24406 81636 24409 245986 293645 24245 24246 60449 25456 293508 24922 302950 29539 59317 294962 29495 25297 64532 25451 25521 25686 25450 25289 85426 171140 25643 29130 25725 300992 116600 83579 29241 25302 680149 29629 25549 84420 58979 29628 29627 24244 79212 79211 140675 114117 24400 366432 64508 50599 363447 25050 171571 140729 66028 81667 25553 24681 25674 29699 25558 24680 116560 25550 81664 66013 25398 60341 60442 171163 140724 84591 140725 65187 170945 25023 83613 83612 192258 24397 306243 29695 29694 58942 84016 25252 171503 29179 553106 84012 58948 25012 191573 25716 116563 24957 81657 24398 192268 24468 60355 25400 315840 140670 50592 24904 29503 83633 81771 117269 24410 25531 501560 24408 50676 29709 29708 64830 64832 25743 170847 24379 24412 65046 24411 116649 29707 24898 79130 29705 140592 170567 171131 24947 60422 24949 29559 29713 24267 116470 29712 24803 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%10231550 ALPK1 signaling pathway 310877 50522 64156 308267 311245 313121 192255 100912032 317546 PKA ACTIVATION%REACTOME%R-RNO-163615.1 PKA activation 24244 302950 64532 25521 64508 25289 81636 25725 29699 29241 84420 293508 ESTROGEN BIOSYNTHESIS%REACTOME%R-RNO-193144.1 Estrogen biosynthesis 289456 116463 691018 25322 296972 79243 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-RNO-8850843.1 Phosphate bond hydrolysis by NTPDase proteins 613267 314312 85260 64467 309390 316077 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-RNO-141444.1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 298850 681050 83836 295661 363059 363198 304951 684439 289150 361416 304477 29564 65201 297522 83572 315648 294429 287830 292085 25515 287624 94266 309179 299147 252902 363193 312754 24673 29489 81738 362548 683983 29648 363174 24672 64515 681185 297176 298594 114592 170845 117281 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 85252 307805 81655 311191 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%10230350 Cellular response to hypoxia 117262 85492 316101 287984 24874 81807 65138 29560 114490 64345 94198 641452 29673 50522 64525 29452 29671 29670 54702 85265 29677 308457 29676 29675 25242 192255 81827 83806 311078 287772 292766 100912032 29669 81920 29668 29425 64156 100360846 361831 117263 25581 29666 303353 365388 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-RNO-74752.1 Signaling by Insulin receptor 29376 25233 81745 81504 84477 313845 297932 363131 298103 25700 246273 84489 29516 29757 289407 361992 83504 362802 65052 368044 296981 298451 299971 66017 83615 25622 25444 170667 29349 436582 54250 498416 25513 25317 297566 29369 312488 25022 85243 117596 29368 94170 170700 116664 116499 366545 60662 360406 60464 170583 289625 25114 170582 85385 79114 170911 25443 29348 361388 170579 170633 50689 24506 24505 116590 314850 25467 24697 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-RNO-2173793.1 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 29417 50522 50689 362110 192255 25591 50554 116590 81516 297893 100912032 81920 300813 304758 100360427 313757 64156 114208 24790 54281 499929 361831 363445 25631 500715 24666 680111 361178 29357 84396 INTERLEUKIN-6 SIGNALING%REACTOME%R-RNO-1059683.1 Interleukin-6 signaling 89829 500985 25622 100361294 25125 24514 24498 VITAMIN E TRANSPORT%REACTOME%R-RNO-8877627.1 Vitamin E transport 25571 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-RNO-350054.1 Notch-HLH transcription pathway 363481 303539 687001 297453 689844 362981 365755 302711 56761 310405 363287 679028 84580 297893 303101 84578 301164 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811436.1 COPI-independent Golgi-to-ER retrograde traffic 64189 114113 363123 294324 299121 84379 29564 29167 360426 140734 289350 299850 306809 252902 81655 294010 79214 58945 307039 29489 84428 83572 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME%R-RNO-5654727.1 Negative regulation of FGFR2 signaling 25443 29348 170579 170633 500526 81504 114486 50522 50689 24673 500985 192255 306141 24672 66017 25444 25622 117281 29349 54250 116590 25317 29369 25022 100912032 83805 29368 314850 170700 116499 60662 60464 170583 64156 BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism 307096 25270 29725 25429 362360 298369 502348 301517 24777 25428 296461 79111 361266 25440 311129 25541 246211 83724 58978 303497 303879 362782 364773 170698 60351 83569 498790 79244 24186 309527 300790 65192 192242 498789 171516 140668 259221 291283 191574 307092 COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade 24232 100360919 155012 113936 113959 24233 298566 406161 64459 24854 24237 29687 84007 365466 114091 362634 25419 295703 64023 64668 54243 79126 445269 117512 29333 312705 192262 299928 289395 303861 299606 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus 171458 306808 50560 59268 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-RNO-1660516.1 Synthesis of PIPs at the early endosome membrane 305419 288762 65052 114554 116699 307842 309855 363131 316457 80849 361632 310155 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 97%10230694 Stimuli-sensing channels 25749 293735 304315 292168 286920 689103 297930 63866 294141 314401 312981 60395 312896 83514 295041 497948 361586 192675 58950 29465 299714 171497 364973 679906 499287 66026 362053 59299 689991 29233 29232 79123 362247 314847 308015 294329 293874 315272 63882 266730 24244 116469 114246 25688 689560 64156 79430 83810 25122 25364 24703 140933 301111 292597 246215 311287 24768 24767 79425 89821 308637 171143 367318 171384 50522 192255 100912032 SIGNALING BY VEGF%REACTOME%R-RNO-194138.1 Signaling by VEGF 24605 293621 25233 24185 81745 24525 25614 25150 295378 25738 29431 29432 363875 246273 361992 293508 170897 25522 25513 85243 117273 83805 24244 170538 24680 94203 25023 300955 679934 170911 296648 25589 50646 81527 25676 286928 114110 117542 29302 114111 29433 89811 60352 362513 360457 289014 296456 315189 310131 79249 310688 84353 83785 79129 315994 66021 316369 294568 315348 314612 81679 246331 308666 64465 362271 311163 313024 24600 25414 25537 360820 58823 682937 64226 29414 56718 54245 299331 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-RNO-168181.1 Toll Like Receptor 7 8 (TLR7 8) Cascade 64156 25742 81647 116725 314322 311245 317468 315648 363328 309452 309295 81771 310877 117269 500133 60350 363520 29260 293624 291921 64044 300447 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 501570 361765 246280 50658 116590 291861 100912032 317546 81736 448830 25493 312688 116663 54226 309361 60587 303024 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10231708 Complex IV assembly 304735 289522 26198 MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228620 MAPK3 (ERK1) activation 50689 54237 25622 170851 100361294 24514 24498 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%10231686 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 302783 24829 306945 303175 24828 689883 290270 680155 366975 64627 117056 690795 680498 685909 680615 365877 P38MAPK EVENTS%REACTOME%R-RNO-171007.1 p38MAPK events 289014 24605 293621 315994 29622 24525 CLEARANCE OF DOPAMINE%REACTOME%R-RNO-379401.1 Clearance of dopamine 308868 24898 24267 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629597.1 Highly calcium permeable nicotinic acetylcholine receptors 25590 25103 81721 54239 170945 171131 79557 ARMS-MEDIATED ACTIVATION%REACTOME%R-RNO-170984.1 ARMS-mediated activation 295347 59109 310738 54245 116478 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190372.1 FGFR3c ligand binding and activation 66017 25444 29349 54250 25317 29369 29368 116499 366061 60662 60464 170583 84489 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-RNO-6794362.1 Protein-protein interactions at synapses 306147 286930 679668 685472 116681 308495 306152 308571 302473 317553 309349 64053 78957 117096 29647 25529 304733 313052 116508 116595 309557 64665 29613 500219 294380 59312 83764 140945 24409 293645 59317 29495 50592 24418 29629 29628 24414 360406 24410 25252 58948 24408 25466 24412 24411 290467 29548 29547 116647 116724 300913 140592 29546 312855 688721 365222 310519 65040 171297 60391 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%10231104 Events associated with phagocytolytic activity of PMN cells 287610 CGMP EFFECTS%REACTOME%R-RNO-418457.1 cGMP effects 140928 63885 25523 81743 171115 25262 54286 191569 308899 29691 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-RNO-114294.1 Activation, translocation and oligomerization of BAX 64625 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10230040 Cell-extracellular matrix interactions 57341 293860 29460 24511 360820 363509 362973 81634 170922 362332 362650 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%10231780 Ribosome-associated quality control 291434 81729 25347 29304 25348 28298 65136 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 81920 292964 293418 81768 100361974 361831 81775 81776 362631 360572 81773 81774 245981 497860 81770 691531 64640 83789 81807 81764 81765 641452 81766 64525 122799 81767 29236 81763 100361060 58927 689284 100361756 312199 29288 287119 29287 293408 29286 315769 29285 294754 124323 289508 498402 29284 287772 29283 292766 29282 296709 64302 29669 64306 29668 100360439 64307 29425 64156 100360846 122772 117263 25581 134486107 29666 303353 365388 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 83806 311078 100912032 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 97%10228820 Activation of BH3-only proteins 25578 116554 64639 25576 56011 25577 313017 171378 140734 246142 29753 492821 56010 58945 64547 29748 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-RNO-5358493.1 Synthesis of diphthamide-EEF2 29565 362191 295394 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 24244 25523 29244 29498 24600 171128 29270 299331 24185 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%10230244 Transferrin endocytosis and recycling 362802 368044 24825 64678 296981 170824 298451 299971 83615 170667 436582 297566 312488 117596 94170 116664 366545 297932 499991 298103 29199 288562 29757 289407 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines 58919 444984 502125 296732 89820 83833 363026 301020 361925 361825 24828 83789 60421 362093 680498 680615 310769 365877 94201 64627 83712 288563 361402 290925 303518 64646 297867 295384 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230654 Scavenging by Class H Receptors 24791 54225 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%10228866 Regulation of mitotic cell cycle 366381 292588 293155 296368 361389 288671 290875 305420 360643 295052 287772 292766 29669 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 117262 25203 64193 85492 54237 24708 294790 310806 292263 25515 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 64515 287280 297176 83806 311078 114592 361765 100912032 361831 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9840310.1 Glycosphingolipid catabolism 316033 500961 363494 114104 303729 25227 311013 316642 83537 303631 117185 289687 25524 94338 315222 24800 365619 310326 684536 362409 307404 84431 312689 300757 301525 294673 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229880 Histamine receptors 85268 24448 170704 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-RNO-9954714.1 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 81773 81774 245981 497860 81770 691531 64640 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 293408 29285 294754 124323 29284 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-RNO-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes 316328 314704 290939 299905 679693 84578 301164 29417 85265 83724 311860 365755 302711 309757 140908 315606 290829 302783 303539 24708 24829 306945 24828 362093 117056 680498 685909 680615 497991 25664 619436 365877 83516 310958 289881 100359816 291567 300367 293500 498112 300206 291440 100362634 102550344 303175 313323 207118 306030 311575 314964 299569 360581 299607 64627 287475 497941 303403 690795 299180 311468 304794 26295 362414 293488 317343 310194 316209 360642 362224 309001 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-RNO-451326.1 Activation of kainate receptors upon glutamate binding 24244 54257 29495 553106 58948 24407 24406 29559 298521 25252 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%10230168 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 492821 64639 24888 64547 64625 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-RNO-204005.1 COPII-mediated vesicle transport 362237 362599 306264 60355 690252 367073 29631 93646 297522 295461 252929 299075 292074 289994 25423 290994 50592 309010 171121 64528 171049 309144 84599 64154 287275 24648 287276 25407 64462 54350 315059 680465 89868 64351 24827 65134 58842 361705 81754 29183 301012 246117 287427 302470 116666 117513 252853 100360302 140673 65165 309678 58817 300743 56042 685144 501550 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231152 Regulation of the apoptosome activity 50689 78963 295961 58918 100360940 63879 25309 116590 690675 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%10230466 Acyl chain remodelling of PE 362039 691905 29354 24913 29692 295631 288025 298579 289733 29526 293711 29359 314075 297694 360426 296048 311341 362434 313997 498741 SELENOCYSTEINE SYNTHESIS%REACTOME%R-RNO-2408557.1 Selenocysteine synthesis GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%10229340 Gap junction degradation 79128 116563 25751 24392 315840 83800 54241 116561 140694 PKB-MEDIATED EVENTS%REACTOME%R-RNO-109703.1 PKB-mediated events 29516 AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 97%10231544 Amino acids regulate mTORC1 500843 297522 100362347 502988 297932 360497 362573 298103 362441 690751 360969 303185 305464 363138 289407 304410 362802 368044 298451 299971 308869 170667 310091 436582 298514 64226 295357 297566 312488 117596 297960 94170 26954 116664 117044 366545 117043 362045 56718 360776 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230980 Fructose biosynthesis 24192 24788 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 97%10230806 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 304569 302935 94165 24437 24842 363849 24708 680522 201097 84017 117062 684828 116685 291145 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-RNO-176187.1 Activation of ATR in response to replication stress 312046 140583 313138 313479 288003 116468 312538 291927 307126 360621 298534 362304 301430 288414 685055 310034 307511 171102 294800 498411 363924 360908 288532 316273 100361529 59102 295596 296178 29728 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%10231280 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 25498 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5658623.1 FGFRL1 modulation of FGFR1 signaling 25443 29349 54250 170579 29369 170633 305539 296072 29368 360903 116499 60662 170583 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%10229966 RHO GTPases Activate ROCKs 64373 25537 117273 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%10230594 IRF3 mediated activation of type 1 IFN 292892 PLASMA LIPOPROTEIN REMODELING%REACTOME DATABASE ID RELEASE 97%10229234 Plasma lipoprotein remodeling 140638 25506 25081 24539 25507 300027 25649 291437 25728 54281 100361444 292697 24530 54225 116548 315218 362850 502970 310900 24186 25080 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 97%10231432 Biosynthesis of DHA-derived SPMs 287454 29527 29328 79242 81639 29277 114097 25086 171522 299732 24296 24297 499689 65030 25290 266682 252931 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229996 Cation-coupled Chloride cotransporters 29501 54300 308069 83629 171373 691209 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%10229962 Surfactant metabolism 362859 192155 29597 29316 25369 24175 24773 246326 25083 245977 25548 25350 25425 314799 170568 302973 494021 50683 29300 84395 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375276.1 Peptide ligand-binding receptors 25298 54305 25706 24179 259224 259222 287730 24613 24938 25380 25107 25264 688605 316019 29385 24180 246075 379044 282832 363682 25340 29180 50672 378939 25342 29141 116677 292409 64042 24182 25033 29191 287673 246759 499194 113959 29397 25601 25245 25593 292419 117518 25007 81509 260319 60337 63887 58812 287561 25569 287562 297795 24604 63850 171104 83567 29363 54258 500157 84348 171101 24232 305236 50577 289023 171551 24806 24808 117549 295144 25570 81503 29256 362505 100360071 497196 497078 25542 64636 57305 308163 84007 117027 360579 171056 25555 89808 29237 25108 192205 29235 192206 29234 84475 29471 171044 102552838 360918 24797 685243 24677 25524 29636 116498 25087 294807 24323 24326 29335 301086 690158 24659 266997 24772 114105 60628 25504 445269 24221 78964 171371 497942 192648 192649 246358 114215 297025 25635 116637 25516 29310 310327 301066 25726 25605 287910 298006 24807 25723 362454 498335 117041 25616 366270 366274 29538 117029 54226 245920 83518 24889 60665 78976 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-RNO-2142712.1 Synthesis of 12-eicosatetraenoic acid derivatives 287454 287424 287425 29328 24404 81639 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-RNO-975634.1 Retinoid metabolism and transport 307096 25216 300027 29216 361266 296972 364773 498790 691984 171517 25615 498789 24710 25703 24856 25702 25680 192259 116673 171516 24771 299858 362558 25081 64047 317322 24539 25236 315644 25649 58920 314941 25728 25592 25056 292697 55939 54225 291283 191574 307092 25080 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 97%10231124 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 83722 312227 363221 58936 295707 307511 25498 301513 291841 287249 316034 29619 306492 363603 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%10230144 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 289014 300944 294975 29344 300045 361109 307850 24185 56011 679140 366017 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-RNO-9609736.1 Assembly and cell surface presentation of NMDA receptors 24412 24411 24408 24410 191573 24409 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-RNO-9616222.1 Transcriptional regulation of granulopoiesis 24705 24252 94201 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%10228888 Eukaryotic Translation Elongation 29565 293725 363241 171361 300033 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-RNO-948021.1 Transport to the Golgi and subsequent modification 362237 362599 306264 503165 289257 305614 64159 79117 29564 314251 252889 29631 93646 314030 297522 117523 308458 295461 252929 294010 292074 84428 289994 290994 54400 171121 24648 64462 89868 290659 64351 361705 29183 301012 24506 24505 287427 683007 64310 114023 302470 304978 116666 117513 100360302 140673 29167 140734 58817 303923 362275 58945 363040 501550 60355 192243 313536 494342 65196 690252 24375 291325 367073 140808 25478 25197 303100 100912115 308757 65271 362625 299075 367252 295319 25547 29582 299756 81519 94273 60384 140568 432392 300674 291990 25423 299121 50592 309010 246310 64528 171049 309144 84599 64154 287275 287276 362162 25407 361073 94189 54350 315059 680465 361207 24827 65134 297428 361577 304290 58842 363136 293456 299850 309451 252902 81754 29489 300888 246117 79120 252853 310411 140940 309678 65165 300743 56042 685144 81655 690961 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%10230808 EPHB-mediated forward signaling 81732 24410 297518 84009 293621 25676 25614 25150 360854 29431 363875 287876 288669 289820 361882 304109 24408 64465 25615 25537 81822 81824 54227 81515 29491 117273 83805 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229352 Transport of connexons to the plasma membrane 394266 24392 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 97%10230372 Erythrocytes take up oxygen and release carbon dioxide 54231 29242 310218 24440 360504 65207 24779 25240 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-RNO-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK 501560 117269 24329 24605 25706 25320 293621 116590 81504 24525 25433 50689 313845 24680 81771 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 97%10229716 Platelet Aggregation (Plug Formation) 25414 24366 24367 25155 685269 81745 24185 29434 59326 171337 81504 83805 361714 29302 295347 25614 24174 24175 313845 25083 54245 85385 24697 315707 HEME DEGRADATION%REACTOME%R-RNO-189483.1 Heme degradation 25303 24861 494500 24360 116599 24451 79239 292737 58978 312382 140860 24565 24186 SPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9845614.1 Sphingolipid catabolism 499210 65183 286896 313339 301118 246115 309147 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231554 Drug-mediated inhibition of ERBB2 signaling 299331 114562 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 97%10231588 Sensory perception of sweet, bitter, and umami (glutamate) taste 170634 78979 29407 78981 78980 25679 78983 78985 286924 690448 680188 100270683 24400 246219 554302 500089 100310876 500091 689869 500101 60449 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 24605 25443 293621 170911 361388 170579 170633 81504 24525 313845 25738 83504 66017 25444 25622 29349 54250 25513 25317 316213 29368 314850 170700 116499 60662 170583 85385 79114 299236 499308 366205 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-RNO-6785631.1 ERBB2 Regulates Cell Motility 29496 25433 64022 498596 25313 432361 298787 24329 59325 117273 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181430.1 Norepinephrine Neurotransmitter Release Cycle 25531 84556 64830 64832 25549 24904 29503 25012 140592 25716 293645 25558 116470 24803 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-RNO-427601.1 Inorganic anion exchange by SLC26 transporters 114629 29440 360670 117267 297910 304784 301010 TGFBR3 PTM REGULATION%REACTOME DATABASE ID RELEASE 97%10231666 TGFBR3 PTM regulation 81751 29192 65205 81707 292788 300802 116510 289231 29543 29610 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism 316559 305889 680668 303676 289175 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230484 Transcriptional activation of mitochondrial biogenesis 293615 361596 24787 306840 24399 25309 690675 KETONE BODY CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228404 Ketone body catabolism 25014 117099 366463 690163 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 97%10231264 Transcriptional regulation by RUNX1 60421 301164 311860 25622 85471 311567 266713 84389 25697 29175 287772 292766 297893 29669 29668 50662 29425 361391 64156 100360846 117263 25581 29666 288563 81650 315606 303353 365388 303518 295384 290829 297867 58919 302783 296732 117262 85492 83833 301020 24829 361925 306945 287984 361825 24828 65138 362093 94198 29673 50522 29671 29670 117056 29677 64033 680498 691504 29676 362675 29675 307151 25193 685909 313038 680615 304690 192255 309626 363014 365877 25720 310258 303730 81827 25172 100359816 315136 116549 681178 83806 313507 311078 500453 361944 25159 100362634 501403 303175 102550344 171046 114483 100912032 24890 64627 690795 304794 309001 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 79116 170841 680915 315344 81528 PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%10229154 Plasma lipoprotein clearance 58851 50522 192255 300438 116563 140670 100912032 266732 65046 25081 314459 298296 306825 294930 64156 80848 25728 25073 25292 680551 81782 54225 83800 266770 54241 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-8868773.1 rRNA processing in the nucleus and cytosol 291317 291434 81729 25347 29304 25348 28298 313707 305258 65136 360828 27139 64205 26962 64462 289809 313167 294282 310720 300092 100910714 363134 362967 681429 117053 100362640 64298 161477 289810 290641 296865 192180 359727 303608 94266 362214 360552 305076 314617 310019 315705 140654 85432 140655 60373 366017 361923 134480579 102551819 117042 287120 287122 291987 499782 294975 103689992 297685 291061 140661 29258 140662 29257 362902 362229 300079 291996 292964 293418 317399 290660 291071 81768 100361974 81775 81776 314713 362631 679140 313744 360574 360572 81773 81774 361262 245981 497860 81770 300045 308201 290556 691531 64640 83789 361159 81764 686999 81765 81766 122799 114021 81767 29236 81763 312706 300050 690297 100361060 309301 58927 293828 292747 689284 288647 100361756 100360664 368084 29288 29287 29286 29285 316317 124323 307850 29284 29283 29282 296709 289740 64302 64306 314830 100360439 64307 58822 64156 298065 314545 122772 361452 134486107 362703 361977 363237 362426 50522 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231424 Biosynthesis of E-series 18(S)-resolvins 29328 79242 81639 299732 25290 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%10228128 Assembly of the pre-replicative complex 313138 313479 292071 312538 291927 360621 362304 301430 366381 292588 293155 296368 361389 288671 290875 305420 360643 287772 292766 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 302783 117262 85492 24829 306945 287984 24828 65138 94198 29673 50522 29671 29670 117056 29677 680498 29676 29675 685909 680615 192255 365877 81827 83806 311078 303175 100912032 64627 690795 361831 288532 316273 362607 24917 295596 296178 29728 INTESTINAL ABSORPTION%REACTOME%R-RNO-8963676.1 Intestinal absorption 65197 25552 432367 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 97%10228478 mRNA Editing: A to I Conversion 81635 25367 COX REACTIONS%REACTOME%R-RNO-140180.1 COX reactions ESR-MEDIATED SIGNALING%REACTOME%R-RNO-8939211.1 ESR-mediated signaling 246332 363026 363425 59325 24605 192218 293621 64466 25335 81745 24185 60421 301164 24525 361810 25614 304157 286924 25149 301128 362110 301252 294515 25718 65179 362809 260321 25154 25686 25643 25522 25513 84424 24244 83571 361967 85471 60349 60664 298184 85385 25098 171068 81664 170911 29183 64022 288588 316123 83828 690966 361365 83830 289561 292778 25233 117526 83503 117017 498109 363633 170897 500569 297893 83805 25433 25313 50662 361391 81647 314322 302783 24329 24827 24829 306945 24828 81687 50689 81686 24516 117056 680498 685909 680615 365877 24600 303175 116590 311764 24890 29414 64627 29149 690795 85252 500633 306792 299331 24919 170906 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 97%10230840 SUMOylation of immune response proteins 83614 25493 25573 362827 690244 301442 309452 309295 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%10228744 Formation of the Early Elongation Complex 689116 311796 298075 289561 292778 305455 288651 679203 361580 294693 83503 117017 291703 498109 363633 288588 266713 316123 502227 690966 361365 84389 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%10231444 Biosynthesis of maresins 29277 25086 171522 24297 266682 65030 25290 252931 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-RNO-9909615.1 Regulation of PD-L1(CD274) Post-translational modification 289874 287772 292766 94201 290783 65248 29669 29668 362040 56010 29425 64156 100360846 116967 117263 25581 29666 81650 303353 365388 58919 290823 117262 85492 192275 407784 64562 287984 65138 94198 29673 50522 100188932 29671 29670 29677 29676 29675 116643 309304 192255 290638 686092 301626 81827 25520 116549 83803 287280 83806 311078 84027 313648 362891 361765 373545 363160 100912032 301555 499342 287643 64701 690315 360967 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231398 RHOG GTPase cycle 503165 361940 60431 29448 78967 305457 307035 360509 290396 307562 100360623 366608 314249 312108 295378 360500 305987 315992 362456 299857 29432 305234 292756 308509 315121 29579 309168 25096 308875 24511 25513 317598 310460 64351 65134 84009 25437 311647 140898 117020 25488 360678 310192 687105 308666 361029 64465 362271 64678 306400 366492 116666 29528 308869 310074 29491 299012 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231394 CDC42 GTPase cycle 314249 312108 295378 360500 362456 498282 296323 309696 310833 306183 305938 63994 312113 362842 313438 308097 500287 25513 306357 306279 246249 291694 688429 362893 314618 288093 307459 305156 367085 498130 313388 360840 314903 309362 305367 361617 306618 303583 66013 84014 303222 317598 287537 287418 310460 64351 246174 311647 363509 78966 140898 361921 309653 117020 303634 301334 360678 363460 310192 114513 687105 362648 304109 361029 64465 306400 310074 29491 299012 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231392 RAC1 GTPase cycle 29448 78967 307035 360509 290396 366608 314249 312108 305987 313845 315992 362456 292756 308509 315121 29579 25096 498282 309696 363235 310833 306183 305938 63994 313438 308097 500287 25513 306357 306279 246249 291694 688429 362893 314618 288093 307459 305156 367085 313388 60664 360840 314903 305367 361617 306618 303583 84014 303222 303501 317598 295635 298404 304282 287537 29146 287418 287746 500246 64351 83620 84031 316639 679934 25437 170911 311647 300067 307016 363509 300186 286928 304546 78966 292279 140898 302976 117542 361921 311450 29355 304530 117020 311793 303634 308021 301334 303653 114116 25097 310192 114243 79249 114513 79129 100362710 66021 294568 362648 315348 308666 361029 64678 306400 313024 366492 58823 682937 310074 299012 310621 100360623 295378 29431 29432 363875 64630 24511 83709 84009 29433 360678 304109 64465 114559 29528 308869 POTASSIUM CHANNELS%REACTOME%R-RNO-1296071.1 Potassium Channels 54262 29718 54261 25736 296395 29738 29737 54263 171146 310303 688996 170899 29731 276720 114244 114245 64199 307900 684516 27150 65195 65272 79218 245986 60449 294962 83579 680149 83535 58979 25560 114117 24400 50599 81667 83633 116560 66016 29747 117018 25468 25469 294065 295360 246153 117023 114032 59324 116695 307234 171011 116491 64120 66022 84390 81657 365241 259273 25559 25743 60326 170847 25470 25472 116489 83588 116649 294961 445371 246325 116745 59266 25327 84429 83731 65180 84020 65198 29713 170739 24520 29712 58981 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228164 Leading Strand Synthesis 59294 288003 289758 116468 301323 25737 89809 288414 85241 361698 PROGRAMMED CELL DEATH%REACTOME%R-RNO-5357801.1 Programmed Cell Death 25578 364419 78963 295961 58918 100360940 63879 64159 298534 307562 29753 25614 25402 25309 679886 291145 24437 680522 201097 361916 684828 170538 64639 29197 365191 311567 24205 64547 291755 84353 116685 140734 690675 58945 29748 282834 83502 64665 56816 498072 246240 171528 266610 259274 83764 306886 306871 116502 361092 64625 690743 501083 83497 60371 304822 24170 317589 64026 363836 296654 305884 81818 25311 298282 84359 287155 316164 171116 367786 25576 114114 56011 287606 25577 353316 313017 171378 363720 246142 492821 56010 25318 64156 24888 114562 363328 299606 60350 29260 292994 64044 364867 287873 50522 50689 305549 246097 117279 25385 246756 192255 116554 83841 116590 100912032 448830 24493 26295 299331 24917 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 97%10228434 The canonical retinoid cycle in rods (twilight vision) 24717 25703 24856 363071 293049 314264 64047 266714 266761 24711 89826 25056 353252 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis 117278 114100 83791 81681 64191 78968 300095 140910 29580 89784 291211 293688 25675 29637 25427 619549 81726 298298 81727 29540 29230 308100 309262 310645 NGF PROCESSING%REACTOME%R-RNO-167060.1 NGF processing 25507 310738 54281 116548 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 97%10229438 Formation of annular gap junctions 79128 116563 25751 24392 83800 54241 116561 140694 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-RNO-983169.1 Class I MHC mediated antigen processing & presentation 287927 297930 93646 297522 295461 308669 296456 79129 66021 690516 58817 81920 361831 366381 292588 296368 56816 361389 288671 290875 305420 360643 363836 64630 287155 289508 64156 116725 287275 287276 294790 311373 24812 140593 293060 362277 361187 687633 50522 315608 50558 361866 192351 360534 316395 317241 362294 315863 29274 305268 140939 192255 303963 295252 316005 353227 314613 313525 305351 301674 287280 303735 295704 363284 29528 500017 361765 64624 299197 498726 500262 117553 100912032 140941 308999 60383 29144 306417 289437 64631 155812 64517 362081 310363 303024 313743 362511 498959 100360914 503446 29468 308283 302987 288596 304920 308968 293023 24223 287706 494223 685029 362087 499114 171043 619577 288921 688993 313722 309591 367785 363188 305792 292757 498011 360926 301515 316575 290692 100909827 683077 282845 312647 361219 498005 360818 361907 687364 89829 302938 685860 309453 690769 171136 500532 680842 303478 100909445 306505 64202 94196 500511 362566 306750 303689 296988 363790 24750 652955 502852 311866 313806 308901 25617 303336 291983 313264 297961 311881 301042 362900 300950 291597 295279 689226 117537 24974 361268 316614 303792 499400 300724 300849 117524 311567 300968 24988 313115 297592 362367 316628 499877 364681 298689 25489 313445 192256 365527 362377 362376 309758 362814 306129 366854 24968 64515 24967 367167 81816 29614 313101 501546 314432 83730 81815 171105 296161 500587 24874 81807 641452 64525 287772 292766 29669 29668 300813 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 81827 83806 311078 301555 685144 306825 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%10231106 Formation of the cornified envelope 689230 299587 295190 309528 361319 307563 307562 306871 291755 304822 81679 291754 102546758 302934 24332 313672 310575 294094 60335 499345 292848 308564 291759 292949 682408 293619 408235 287925 291760 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10229350 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 24392 RHOT2 GTPASE CYCLE%REACTOME%R-RNO-9013419.1 RHOT2 GTPase cycle 287156 192647 171086 497974 GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism 114508 25741 24651 362282 24334 25104 316265 315722 292804 25060 297522 292138 24189 296973 289608 54283 25634 25438 685076 24385 66020 303565 100364027 24638 24959 294321 60416 498731 24191 24849 25059 24640 24642 24644 25658 29573 117276 24362 65152 294429 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 245922 81738 683983 53372 25497 499974 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%10230368 O2 CO2 exchange in erythrocytes 54231 304805 29242 171015 310218 365345 24440 360504 65207 24779 25240 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling 29613 81737 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 97%10230374 Methionine salvage pathway 288912 298934 298227 305177 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230436 Mitochondrial iron-sulfur cluster biogenesis 290985 79122 29189 313786 288740 360826 102550385 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%10231472 Activated NTRK2 signals through FRS2 and FRS3 313845 25054 25730 24225 81504 314850 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229594 Basigin interactions 360606 307811 50687 300338 25390 25246 24511 50567 29409 25518 65200 50719 80878 25027 116726 83509 25650 84551 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-RNO-202427.1 Phosphorylation of CD3 and TCR zeta chains 294269 300678 64019 313050 25300 24981 24699 25710 24986 24932 315707 295338 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%10229838 ICOS co-stimulation 366508 298947 64545 60664 497931 170911 499415 497932 25513 85243 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-RNO-8857538.1 PTK6 promotes HIF1A stabilization 25433 366275 24329 300160 29560 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 117262 64193 85492 24708 294790 25515 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 64515 83806 311078 114592 287772 292766 100912032 29669 29668 29425 64156 100360846 361831 117263 25581 29666 303353 365388 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 97%10228356 Processing of Capped Intron-Containing Pre-mRNA 366693 300208 294232 689116 687575 298075 501926 368070 117259 305586 295334 311670 497967 299256 501285 299811 362098 361449 289582 363082 259170 302969 297522 494445 89827 79227 29578 360803 81781 300996 313030 294783 29667 313035 59087 298342 79256 501621 292019 292810 64200 83624 362687 310687 290519 499314 319110 287113 361808 100910202 291295 317612 314336 500790 117280 117282 295428 366276 246216 291060 689890 500538 298385 360726 361814 303346 287530 366163 287415 362361 681062 297695 245976 309651 313588 360972 307474 84401 116697 691538 295284 680891 361035 311855 367930 683927 245957 302557 304859 362819 290284 313450 362260 365407 313449 314417 690303 305714 362152 362394 686980 80846 313583 314313 311166 679890 170933 361859 290614 288588 316123 690966 361365 289561 292778 83503 117017 498109 363633 305884 64156 50522 192255 100912032 308968 24668 302855 24468 296320 294429 291794 287830 291874 362281 113975 292085 295692 117021 362335 315170 687711 288701 313433 366016 313308 58958 362153 300361 363005 362557 292535 65274 294711 113929 296219 100362099 293862 114612 681031 100361269 245922 312474 81738 288718 500242 683983 192246 53372 308650 25594 25497 361990 302670 499974 303607 363151 85434 171365 60376 680737 305479 140931 690585 307410 171552 301432 361887 303057 498171 499020 688288 287768 29497 299620 295270 117045 304277 498600 290666 291877 289315 64510 89819 361542 362990 84486 292729 361788 300687 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression 682390 81773 298700 81774 691947 245981 299872 497860 81770 293427 288599 303831 288516 691531 299899 64640 171350 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 54318 29288 29287 29286 29285 124323 29284 296302 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 299027 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 117045 81768 292762 100361974 362952 81775 81776 362631 292148 300069 293484 360572 MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10229634 MicroRNA (miRNA) biogenesis 298533 311130 299284 363006 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 117262 85492 316101 287984 24874 81807 65138 29560 64345 94198 641452 29673 50522 64525 29452 29671 29670 54702 85265 29677 308457 29676 29675 192255 81827 83806 311078 287772 292766 100912032 29669 81920 29668 29425 64156 100360846 361831 117263 25581 29666 303353 365388 PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism 100363253 361274 287406 305149 313574 117260 298881 497811 290029 311422 171047 361068 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975578.1 Reactions specific to the complex N-glycan synthesis pathway 25478 308757 94273 24375 140568 432392 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 97%10231426 Biosynthesis of EPA-derived SPMs 29527 29328 79242 81639 299732 25290 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 97%10229862 Beta-oxidation of pristanoyl-CoA 83842 25541 83522 311849 79244 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 97%10231460 Biosynthesis of DHA-derived sulfido conjugates 114097 499689 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%10230706 Ca2+ pathway 365901 100361818 282581 307401 24674 25400 24675 497961 313121 64199 64512 24525 50664 317674 79218 84353 245986 140584 60449 64558 294962 83579 680149 58979 24244 114117 24400 81667 289878 161452 266715 29748 688297 MAP KINASE ACTIVATION%REACTOME%R-RNO-450294.1 MAP kinase activation 117269 500133 363520 313121 362491 363855 25272 50522 50689 84351 24516 289014 363193 24673 315994 192255 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 100912032 317546 81736 116663 64156 309361 60587 81647 303024 116725 314322 311245 315648 309295 81771 CS DS DEGRADATION%REACTOME%R-RNO-2024101.1 CS DS degradation 50568 316033 25181 363513 500961 25227 300757 29139 301525 404783 300993 25393 367166 24434 81651 294673 114122 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-RNO-991365.1 Activation of GABAB receptors 29718 64199 286924 24611 79218 81636 245986 60449 302950 294962 64532 25686 25289 25643 83579 81657 29241 680149 25743 84420 170847 58979 116649 114117 24400 50599 64508 81667 83633 116560 29713 81664 29712 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-RNO-74751.1 Insulin receptor signalling cascade 29376 25443 170911 29348 25233 361388 81745 170579 170633 81504 50689 84477 313845 363131 246273 84489 24506 24505 29516 361992 83504 65052 66017 25444 25622 29349 54250 498416 116590 25513 25317 29369 25022 85243 29368 314850 170700 25467 116499 60662 60464 170583 289625 25114 170582 85385 79114 FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling 266610 64044 246097 25385 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 97%10230670 Metabolism of ingested SeMet, Sec, MeSec into H2Se 25331 363285 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%10229456 Fcgamma receptor (FCGR) dependent phagocytosis 117538 309014 289211 297518 259242 310178 79113 361527 65261 367901 25017 360426 81504 25614 25150 295378 100360919 25738 29337 29431 363875 301252 288669 25096 311860 25513 81515 85243 83805 300678 170538 25734 29340 81732 295279 300955 679934 170911 25155 286928 117542 50689 360854 25097 79249 287876 294568 289820 315348 308666 64465 362271 313024 58823 81822 682937 81824 54227 116590 54245 299331 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%10231212 Synaptic adhesion-like molecules 24408 29495 24410 308495 50592 25529 29629 29628 25252 24412 24411 360406 64665 58948 83764 140945 24409 688721 365222 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 97%10228228 Gluconeogenesis 24959 294321 498731 24191 24849 24642 114508 24644 29573 362282 24334 24362 25104 316265 292804 292138 24189 25634 25438 66020 303565 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-194313.1 VEGF ligand-receptor interactions 114111 89811 360457 94203 83785 25589 114110 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 97%10231470 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 29527 25290 SYNTHESIS OF PG%REACTOME%R-RNO-1483148.1 Synthesis of PG 114101 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-RNO-350562.1 Regulation of ornithine decarboxylase (ODC) 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 689588 24314 81827 83806 311078 287772 292766 29669 24609 29668 25502 29425 100360846 117263 25581 29666 303353 365388 INTERLEUKIN-33 SIGNALING%REACTOME%R-RNO-9014843.1 Interleukin-33 signaling 361749 25466 25556 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%10228338 Interconversion of nucleotide di- and triphosphates 29261 619580 497778 64045 290741 294521 313560 298410 102238592 58964 362720 24183 116484 24184 311833 299976 685579 29223 83782 191575 365985 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-RNO-9959399.1 SLC-mediated transport of oligopeptides 287478 246239 117261 246280 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-RNO-975110.1 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 293624 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-RNO-166016.1 Toll Like Receptor 4 (TLR4) Cascade 641452 246240 29337 266610 306886 60371 299827 291359 296321 25622 680127 287545 246116 252961 362788 292892 64156 25742 81647 116725 314322 311245 315648 363328 309452 309295 81771 140694 310877 117269 500133 60350 363520 29260 293624 291921 64044 300447 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 246294 171574 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 81920 448830 25493 312688 25751 116663 54226 309361 60587 361831 303024 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 97%10228788 Fibrin formation 25268 65051 304917 289055 24366 24367 685269 60327 79224 29302 29366 MET ACTIVATES RAS SIGNALING%REACTOME%R-RNO-8851805.1 MET activates RAS signaling 313845 361396 364686 24605 293621 24553 85385 24446 81504 24525 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion 301226 25383 498251 170912 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 97%10228464 RHO GTPases activate PKNs 302783 25578 24829 306945 24828 81745 29753 29355 117056 680498 83724 363875 685909 680615 25594 365877 500569 303175 307511 25576 56011 25577 313017 117273 64373 64627 56010 690795 304813 114004 298144 116670 24208 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%10230660 ECM proteoglycans 24617 311061 25567 29331 81008 170921 24511 116640 58968 685269 29302 29139 296456 25592 25393 499271 114122 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%10230800 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 287102 80722 293897 295445 502097 114107 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-194002.1 Glucocorticoid biosynthesis 299270 25146 25116 360348 25117 24470 682974 29632 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%10229540 TCF dependent signaling in response to WNT 25578 63879 24185 303251 64558 84424 303811 291678 64512 317674 24205 309179 299147 79257 312754 24881 83721 501584 113927 84353 103691373 679110 161452 304832 282581 25233 364754 29417 287772 292766 297893 29669 29382 29668 29425 58822 64156 100360846 117263 25581 29666 315648 81650 303353 365388 290829 117262 85492 287102 80722 293897 287984 295445 502097 114107 65138 362093 94198 29673 50522 29671 29670 301965 29677 363193 120099577 503000 29676 498997 29675 24673 498233 691857 291209 65027 192255 25565 295251 289026 312451 29134 81827 310704 24672 300837 116549 313589 83806 312936 311078 309419 308051 84027 117281 499918 361765 299802 102550344 679158 290317 266772 500863 100912032 301555 246768 360990 303412 364712 293165 140585 140586 85252 300673 304794 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%10230142 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 289014 300944 294975 79426 300045 361109 307850 56011 679140 366017 REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs 117262 85492 24605 293621 287984 25676 65138 94198 24525 29673 50522 29671 29670 29677 29676 29675 100909827 192255 81827 83806 311078 287772 292766 305539 100912032 296072 301555 29669 29668 29425 64156 100360846 24592 117263 360814 25581 25597 29666 314596 192126 29372 303353 304893 365388 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-RNO-5357956.1 TNFR1-induced NF-kappa-B signaling pathway 688466 81859 687813 498803 83427 115771 114210 312937 308267 364386 63879 313121 25625 317546 60383 84351 246294 309361 306886 246756 24835 309295 60371 290864 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230104 Interleukin-27 signaling 290655 29144 680609 100361294 25125 24514 365368 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%10229814 PERK regulates gene expression 54318 299027 29702 296302 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 362809 29527 307096 498789 24886 25527 25526 171516 59103 29224 58962 361266 291283 191574 364773 498790 307092 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%10230092 Synthesis of UDP-N-acetyl-glucosamine 363109 297393 498272 297417 498486 360518 302972 81759 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins 295347 25614 25414 54245 24366 24367 685269 171337 83805 29302 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-RNO-8851680.1 Butyrophilin (BTN) family interactions 302934 497811 306956 306957 684480 288375 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-RNO-187577.1 SCF(Skp2)-mediated degradation of p27 p21 58919 117262 85492 294790 287984 65138 94198 29673 50522 29671 29670 29677 29676 362485 29675 192255 499655 81827 366275 287280 83806 295052 311078 287772 292766 94201 100912032 29669 83571 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1306955.1 GRB7 events in ERBB2 signaling 29496 432361 84427 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-RNO-445717.1 Aquaporin-mediated transport 64199 79218 245986 60449 25480 25240 25241 293508 25386 65054 294962 65133 286758 25521 25293 25132 367316 29172 29171 25725 83579 81830 680149 58979 114117 24400 81667 24221 29699 25108 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%10230464 Acyl chain remodelling of PS 362039 691905 29354 24913 29692 295631 316039 298579 361686 29526 85311 29359 296048 311341 362434 498741 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231506 Negative regulation of NOTCH4 signaling 24185 CELL CYCLE CHECKPOINTS%REACTOME%R-RNO-69620.1 Cell Cycle Checkpoints 316794 363059 85482 192218 114212 290805 298534 29564 287927 685055 310034 308755 297522 361815 306734 300711 690043 297627 296099 295052 360588 497856 64012 294800 114494 498411 308669 291787 289468 100361529 140583 362827 362704 309179 299147 312754 140734 361831 58945 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 25576 56011 25577 313017 64156 116725 315648 50522 363193 252902 24673 362548 192255 24672 287280 117281 361765 100912032 311575 85252 303024 360908 288532 316273 59102 295596 296178 29728 312046 313138 313479 25578 312538 291927 307126 360621 362304 301430 29753 83572 307511 171102 300126 685474 308937 287101 304798 83571 360860 25203 54237 25515 94266 113927 29648 363174 64515 681185 297176 298594 114592 170845 308443 303037 306464 679342 296137 291441 24669 257649 257644 64041 287598 317252 307805 311191 114764 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 83836 295661 58936 363198 304951 288003 684439 116468 289150 361416 304477 65201 288414 305000 287772 292766 29669 29668 56010 29425 58822 100360846 117263 25581 29666 303353 294429 365388 287830 117262 85492 292085 24829 306945 287984 287624 65138 94198 29673 29671 29670 29677 29676 29489 81738 29675 683983 81827 24842 83806 311078 84027 303175 497672 64557 64627 363924 303194 81655 315969 290997 64046 290631 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-RNO-9939291.1 Matriglycan biosynthesis on DAG1 362567 361368 311202 362520 299841 493574 257647 114489 308390 293667 140568 313139 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%10230232 N-glycan trimming in the ER and Calnexin Calreticulin cycle 50522 29144 64156 293719 117263 116643 361014 192255 64202 298012 29468 100912032 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 97%10231030 UCH proteinases 25490 287772 292766 29669 29668 29425 64156 100360846 117263 25581 29666 498560 303353 293494 365388 64646 315723 29545 360853 502125 65137 117262 304298 85492 316440 306257 311026 362258 291737 361925 315523 296084 287984 85423 24828 65138 94198 29673 50522 29671 29670 29677 29676 29675 680615 287876 192255 365877 81827 83806 311078 100912032 64557 26295 24919 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 97%10230336 ISG15 antiviral mechanism 292892 50689 312688 25738 295704 25489 116725 298693 54287 306204 114558 24667 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 97%10230846 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 65046 317674 362550 116563 306782 140670 83800 54241 116561 64512 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 97%10230200 Heparan sulfate heparin (HS-GAG) metabolism 363513 25216 25697 294449 688293 293451 64537 295430 360630 84406 364476 108349781 303218 302489 292155 29633 363618 114002 368128 684979 299907 691984 171517 25615 116673 24771 317322 25236 58920 25592 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229358 Lanosterol biosynthesis 83791 81681 29580 89784 291211 25675 29637 619549 81726 81727 29230 308100 310645 METABOLISM OF SEROTONIN%REACTOME%R-RNO-380612.1 Metabolism of serotonin 29539 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%10230850 PINK1-PRKN Mediated Mitophagy 192647 641452 50522 246294 56816 64862 362245 361321 192255 365601 363836 83529 83532 299827 83531 299514 266601 298575 685620 363254 300075 308416 304017 113894 100912032 81920 64156 116725 KERATAN SULFATE DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230514 Keratan sulfate degradation 314771 316033 292073 64507 500961 81682 58968 300757 291015 301525 84400 299825 294673 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%10230590 Signaling by Hippo 292994 56011 300289 65189 303251 305922 29753 65157 297387 308265 311622 299116 360920 25402 363014 SIGNALING BY RHO GTPASES%REACTOME%R-RNO-194315.1 Signaling by Rho GTPases 361940 60431 78967 305614 64159 305457 307035 360509 290396 307562 81504 366608 314249 25614 312108 360500 305987 313845 81522 315992 362456 299857 305234 292756 308509 315121 29579 309168 25096 308875 498282 296323 309696 310833 306183 305938 63994 312113 362842 313438 308097 500287 306357 306279 246249 291694 688429 362893 314618 288093 307459 305156 367085 498130 313388 360840 314903 309362 305367 361617 303583 84014 303222 303501 295635 304282 29146 287746 500246 83620 84031 316639 300067 307016 300186 304546 292279 302976 311450 29355 304530 311793 308021 25488 303653 114116 25097 114243 29611 314212 64303 688319 306871 299809 117273 313050 360678 362548 171115 306417 308968 25578 60377 29495 25513 60664 25023 25437 170911 25515 50646 302855 291755 301007 29648 293497 363009 116685 116478 362938 362859 315829 363174 303553 64515 361029 306400 64678 681185 287543 297176 298594 366492 114592 289229 306506 25306 170845 360849 89816 308443 303037 498331 306464 310074 312077 679342 316213 296137 291441 314850 24669 299012 257649 312667 192207 257644 64041 305645 140922 287598 317252 307805 311191 114764 500545 25448 305270 363028 286993 54241 102555739 315164 114514 298850 681050 83836 295661 363198 304951 684439 289150 361416 304477 295378 29431 363131 29432 363875 24255 65052 24511 83615 363445 315707 54350 81732 83709 65134 84009 287624 29433 114612 29489 287876 316369 289820 25594 361882 304109 64465 114559 25537 171549 81822 192348 54227 29491 316226 81655 116717 363059 297518 117259 360915 29448 29564 303251 297522 288669 311860 64351 170824 300955 679934 286928 303811 117542 498798 309179 360854 299147 312754 83721 79249 84353 365407 79129 66021 294568 315348 81679 308666 362271 313024 116666 58823 682937 311030 81824 140734 58945 310519 117538 259242 306152 367901 64665 83764 315840 117550 81634 293860 64630 81818 500569 25576 56011 25577 313017 171041 304813 315648 114004 298144 116670 24208 50689 363193 252902 24673 261736 24672 29528 117281 116590 85252 313934 299331 117039 314906 304893 503165 81745 29753 24392 301252 83572 84427 56084 363235 25522 307511 64373 24244 170538 24680 306618 66013 317598 298404 287537 287418 310460 307098 120099896 246174 311647 363509 310635 310999 25270 78966 140898 361921 94266 309653 117020 303634 307170 301334 65183 363460 310192 114513 293024 100362710 687105 362648 362279 308761 29275 56785 64160 363031 83809 498174 309722 81531 304007 315265 503306 365355 305341 685357 79115 29681 297406 295588 297383 94195 83502 296060 310621 360942 65201 100360623 117955 315686 29417 367235 361813 54308 305605 24852 192277 310090 366170 498547 83724 303888 116547 679082 296162 313216 300030 171581 500929 300115 315732 309175 25230 690130 310013 300225 288057 303611 85428 300111 362988 291999 362993 171296 246314 293947 312640 360596 56010 79239 299145 313618 100363276 678766 313838 317296 689997 367902 114562 300838 29745 294429 311721 113960 287830 291000 83425 302783 84510 501099 363213 306004 292085 24829 306945 24828 117056 680498 81738 116643 685909 683983 680615 365877 308869 303175 301555 24264 64627 690795 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-RNO-69200.1 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 24708 362485 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%10230172 Deposition of new CENPA-containing nucleosomes at the centromere 298850 302783 65137 363198 308839 684439 288272 289150 24829 689399 361416 306945 689296 316602 24828 499873 313048 362548 685909 680615 365877 681185 303175 306464 679342 25498 64627 690795 307805 83712 25448 305270 315164 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-RNO-112313.1 Neurotransmitter uptake and metabolism In glial cells 29482 24957 170567 29483 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-RNO-77352.1 Beta oxidation of butanoyl-CoA to acetyl-CoA 140547 64304 113965 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%10230754 HDMs demethylate histones 500569 317432 317425 312440 684297 689582 64627 304809 313539 682469 266670 304495 680498 363630 103689969 301128 360665 298144 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%10228474 mRNA Splicing 300208 294232 689116 298075 501926 368070 117259 295334 497967 501285 361449 363082 259170 302969 494445 29578 360803 81781 294783 29667 298342 79256 292019 292810 64200 83624 362687 310687 319110 287113 100910202 291295 314336 500790 117280 117282 366276 246216 291060 689890 500538 298385 361814 303346 287530 366163 287415 362361 297695 245976 309651 313588 84401 691538 295284 680891 311855 367930 245957 302557 290284 313450 302855 362260 313449 690303 362152 362394 686980 80846 313583 314313 679890 170933 361859 290614 288588 24468 296320 316123 690966 361365 289561 292778 83503 117017 498109 363633 305884 291794 687711 288701 313433 362153 300361 363005 292535 294711 100362099 293862 114612 681031 100361269 312474 288718 500242 192246 308650 302670 303607 363151 171365 85434 680737 60376 305479 140931 690585 307410 171552 301432 361887 303057 498171 688288 287768 29497 299620 295270 498600 289315 64510 89819 362990 84486 300687 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%10230482 Degradation of DVL 117262 85492 287984 65138 303811 303251 94198 29673 50522 29671 29670 29677 29676 83721 29675 291209 192255 81827 83806 311078 287772 292766 266772 100912032 301555 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%10230768 STAT6-mediated induction of chemokines 299827 498840 ADAPTIVE IMMUNE SYSTEM%REACTOME%R-RNO-1280218.1 Adaptive Immune System 293618 50557 689004 313644 361400 84349 24605 313785 292844 293621 292843 292846 407756 307199 25660 361673 81504 25408 24525 288244 100910497 25066 25150 680844 313845 300649 362443 312711 309684 305081 307366 363577 574531 25361 24232 29748 100361818 24674 24675 366381 292588 296368 56816 361389 288671 290875 305420 360643 363836 287155 81515 83805 295338 294269 300678 313050 25300 24981 25710 24986 24932 24703 311373 24812 140593 293060 362277 361187 687633 315608 50558 361866 192351 360534 316395 317241 362294 315863 29274 305268 140939 303963 295252 316005 353227 64019 314613 313525 305351 301674 303735 295704 363284 500017 25262 54286 64624 299197 498726 500262 117553 140941 308999 60383 29144 306417 289437 64631 155812 64517 362081 310363 313743 362511 498959 100360914 503446 54259 29468 308283 302987 288596 304920 308968 293023 25578 24223 287706 494223 685029 362087 499114 171043 619577 288921 688993 313722 309591 367785 363188 305792 292757 498011 360926 301515 316575 290692 100909827 683077 282845 312647 361219 498005 360818 361907 687364 89829 302938 685860 309453 690769 171136 500532 25622 680842 303478 100909445 306505 25513 64202 94196 85243 500511 362566 306750 303689 296988 363790 24750 652955 502852 311866 60664 313806 308901 25617 303336 291983 116689 313264 297961 311881 301042 362900 300950 291597 295279 689226 117537 25023 24974 361268 170911 316614 25155 303792 499400 300724 300849 117524 311567 300968 24988 313115 297592 362367 366508 316628 499877 364681 298689 25489 313445 192256 365527 362377 362376 309758 362814 306129 366854 24968 64310 24967 64515 367167 116743 81816 29614 313101 501546 314432 83730 81815 171105 296161 500587 302934 25751 287531 289758 316344 25424 296320 259221 83800 25425 89809 313702 365542 54241 684529 361704 309812 24984 294273 306332 316235 81685 288003 290644 116468 81709 50654 399679 25679 24874 25737 81807 294339 81678 288414 25697 29175 305000 641452 64525 81511 100360919 25738 29337 29431 29432 366962 363875 246273 361992 24511 300813 63865 315707 24699 298947 64545 497931 499415 497932 287624 29433 299850 29489 64465 171549 65046 316226 685144 81655 29448 29564 287927 297930 93646 297522 295461 294010 85248 84393 308669 314473 89821 300955 296648 309179 299147 296456 171574 312754 315189 310131 79129 66021 116563 29167 140734 58817 690516 295347 81920 361831 58945 497811 289211 293502 315740 25233 367901 117550 64630 25423 299121 289508 140670 56011 361308 64156 84357 116725 171041 311245 315648 287275 287276 309295 140694 294790 313121 362491 50522 84351 363193 252902 24673 192255 25599 116596 297596 24672 287280 308267 29528 117281 361765 100912032 81736 25493 29414 309361 303024 314906 289168 81745 24185 353302 306956 306957 684480 84428 288375 293508 24244 289874 287772 29434 292766 59326 171337 94201 361714 290783 65248 29669 29668 362040 56010 29425 100360846 116967 83712 117263 25581 29666 81650 315606 303353 365388 290829 58919 290823 302783 117262 85492 192275 407784 64562 24829 306945 287984 24828 65138 362093 313048 94198 29673 100188932 29671 29670 117056 29677 680498 29676 29675 116643 24934 685909 24931 680615 24930 309304 498079 290638 362046 365877 310727 686092 308417 301626 316241 81827 294048 25520 308501 116549 83803 54266 83806 308995 25639 298702 311078 498287 84027 287818 313648 353253 362891 303175 100913063 64226 499356 373545 305584 688041 363160 304349 689853 301555 499342 364049 287643 474146 171369 64701 56822 64627 89843 306825 690315 684984 690795 56718 360967 499537 304794 25713 361710 301229 100361633 360640 361618 360647 25109 83477 25464 FOXO-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10229502 FOXO-mediated transcription 84482 25578 50554 25233 56011 24185 25577 313017 301164 309757 293615 29414 56010 25631 302415 294515 313558 24370 29357 60331 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231368 Interleukin-9 signaling 116558 24918 25125 25326 25126 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors 294972 81506 25104 81522 29216 299857 24565 499330 316062 25668 296167 306262 361300 50671 171053 367323 25551 85496 499328 64392 293504 300886 24778 64001 297508 300328 353255 64845 313241 313520 29319 309465 361751 311536 25035 361472 687008 100125370 361836 289095 170551 288240 301221 64533 287711 29723 24312 294088 362134 299699 298490 316559 83578 305889 291939 360639 680668 303676 363069 289175 680308 360511 303333 362657 751787 64300 315085 295229 25732 298653 363118 305248 50622 54349 60581 50621 29142 365699 290947 362942 314459 80848 361884 293154 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%10230038 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 57341 29460 360820 363509 362973 81634 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides 286995 290257 613220 613223 613224 286958 296354 613225 641627 311558 50585 83687 94195 305842 170496 641624 308873 290856 116547 296321 24691 24932 299606 683849 316519 103690254 362347 25052 24618 310553 499925 499926 296290 641632 641636 29692 641651 641650 24854 24620 246238 308163 24941 299567 171162 641644 84355 685161 100361909 310611 314615 641652 641655 84387 641657 641656 305354 498659 301034 641658 498658 316010 MET PROMOTES CELL MOTILITY%REACTOME%R-RNO-8875878.1 MET promotes cell motility 360606 170921 24511 361388 171337 287942 81504 83805 295347 303517 25614 309816 691517 313388 24553 54245 363875 24446 NEUREXINS AND NEUROLIGINS%REACTOME DATABASE ID RELEASE 97%10231120 Neurexins and neuroligins 286930 679668 685472 116681 64053 78957 29647 117096 304733 313052 116508 116595 309557 500219 58948 294380 59312 59317 29495 24418 24414 29548 29547 116647 116724 29546 65040 171297 60391 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-RNO-112303.1 Electric Transmission Across Gap Junctions 266706 362979 315435 50564 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%10231236 TBC RABGAPs 363123 117103 365372 25532 29448 24855 313234 361697 84379 60445 266688 303734 246294 499768 64862 79434 361227 58974 64670 366896 501854 79121 317580 360827 311911 81830 287110 360956 288700 365793 292886 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 97%10230952 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 302783 24829 306945 500569 303175 24828 29355 64627 117056 690795 680498 83724 685909 680615 298144 24208 365877 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%10230490 Activation of Matrix Metalloproteinases 291848 290257 300338 81707 25481 103690254 25335 116510 306404 81687 29175 362347 81686 63849 25052 25627 65205 24291 83513 24691 29268 29543 117061 85253 54281 299606 683849 PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism 290257 24179 116700 64632 302813 252929 266758 60627 83711 171455 116654 50556 302668 245709 294075 25653 25627 266704 293142 25196 54242 301265 24715 25506 25608 306515 24310 64017 25204 24391 24590 59301 252881 113902 302526 64549 25253 24482 305287 25447 25329 171101 294698 299903 24506 24505 29200 113936 25040 24504 266607 CREB PHOSPHORYLATION%REACTOME%R-RNO-199920.1 CREB phosphorylation 501560 117269 289014 315305 81771 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME%R-RNO-400206.1 Regulation of lipid metabolism by PPARalpha 24360 312947 296732 363026 25747 365755 302711 83724 497991 84578 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229976 Tight junction interactions 84006 362279 116479 307237 81918 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-264642.1 Acetylcholine Neurotransmitter Release Cycle 85426 25531 84556 64830 64832 25012 140592 25716 60422 293645 25558 116470 24803 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%10228638 Developmental Biology 313644 297518 24605 289257 293621 305614 64159 306628 24586 314251 307562 81504 24525 25614 25573 25150 116696 313845 117523 308458 290905 301442 288669 84482 311860 84393 300955 316639 361388 29302 60352 360854 296456 171574 84353 81679 246331 116563 50554 81824 170851 24553 161452 314641 25233 25017 59312 50938 306871 304822 25311 140670 297893 81515 117273 83805 309757 364686 84357 312213 29148 64030 300242 300247 300248 303519 81771 140694 337868 311384 116483 315615 680454 24329 58960 300250 287191 117516 102553726 502694 309957 299737 29361 450230 24923 100364550 294853 50689 309280 25454 170577 315711 498607 316009 450228 134481131 450227 25453 690478 450229 100359886 25664 497995 369017 312451 450225 289392 361537 100361571 407757 407758 499497 266717 120095335 66023 287701 116590 287700 287702 81518 306790 361432 81521 288480 296789 29414 25525 680104 84382 85252 24705 361568 25418 25415 25417 25416 299331 25094 363517 252892 116470 289352 287697 287699 406227 287698 406226 406228 29376 60629 25626 83510 29423 683313 290868 305417 24185 680060 84578 308376 361597 83501 310207 120093742 84477 292028 84347 313498 50645 360034 361364 362572 360715 680703 407762 134478810 291624 301252 266729 315320 294515 84427 102551497 293508 315324 407760 315323 29495 60427 680152 315318 100363184 360600 65208 25622 310630 116690 54319 25513 57033 25714 85243 685544 299766 140908 29751 360626 64373 360623 287675 303523 24716 24718 303528 60664 140729 287679 85385 303527 297357 680071 24680 353305 312477 286908 116671 171119 361604 140724 690660 498898 140725 100909661 306804 25136 286912 306013 170911 78966 366508 310192 291755 306400 116743 366492 291754 314850 102546758 302934 24332 313672 310575 25751 294094 60335 499345 292848 308564 291759 83800 292949 682408 293619 408235 54241 287925 291760 689230 299587 295190 309528 361319 307563 24252 295378 25738 29431 29432 363875 24511 685269 498416 94201 362993 25631 81650 79114 29357 81732 50687 24410 83709 24699 686310 24338 84009 316539 300802 287989 25676 312275 81687 116683 310643 29433 84358 81686 29192 79208 360546 171287 292788 94268 306636 298528 287876 316369 289820 312279 361882 25720 501203 81751 304109 24408 64465 116549 114559 25615 25537 84027 29210 81822 83841 171046 54227 289231 29491 65046 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-RNO-6811442.1 Intra-Golgi and retrograde Golgi-to-ER traffic 503165 363059 289168 79117 29564 252889 60562 314030 500906 353302 294010 84428 309922 83572 114113 309523 85248 54400 84393 313493 313254 315668 360953 303575 314473 289309 290659 64351 300158 116692 116691 64310 114023 304978 140673 29167 140734 192152 303659 306809 58945 100359675 25151 60355 293502 315740 360426 84589 367308 64621 117548 25218 117550 312689 60384 289397 300674 291990 64516 299121 246310 361308 171291 84599 64154 171041 365793 362283 500249 362162 361073 94189 363123 361207 65134 113886 297428 287624 361577 120097389 84379 304290 289350 293456 294286 299850 309451 252902 81754 307039 29489 300888 286932 293344 140932 685079 79120 65277 64187 364981 64189 117051 294324 29528 246209 171549 310411 140940 309798 311919 65165 296649 316226 296750 367915 81655 79214 690961 314906 363288 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-RNO-1660514.1 Synthesis of PIPs at the Golgi membrane 305419 65052 64310 114554 307842 309855 316457 81747 116482 364629 116720 140940 363131 114089 361632 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-RNO-111452.1 Activation and oligomerization of BAK protein 116502 64625 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9034793.1 Activated NTRK3 signals through PLCG1 29613 81737 25738 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-RNO-69615.1 G1 S DNA Damage Checkpoints 58936 114212 362485 300711 295052 287772 171102 292766 685474 29669 83571 304798 29668 360860 114494 29425 58822 64156 100360846 117263 25581 29666 303353 365388 140583 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 113927 192255 81827 287280 24842 83806 311078 84027 361765 100912032 311575 303024 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229354 Gap junction assembly 266706 84403 25655 50563 50564 394266 29585 497913 29584 24392 29586 79217 363677 266707 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamin B6 activation to pyridoxal phosphate 64533 83578 54349 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 97%10228388 Nucleotide salvage 25368 292072 291585 289801 304944 295620 315219 311864 362638 291824 25095 362015 290029 192357 79127 24165 117533 24465 25028 297389 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events 302950 294962 64532 25289 83579 29241 680149 84420 58979 64199 24174 114117 24175 24400 25740 64508 79218 362477 25083 308118 81667 81636 245986 60449 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%10229152 LDL clearance 266732 65046 298296 300438 116563 294930 140670 81782 54225 83800 266770 54241 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-RNO-170670.1 Adenylate cyclase inhibitory pathway 302950 286924 64532 24611 64508 25686 25289 25643 81636 29241 81664 84420 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%10230048 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 57341 24511 360820 170922 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-RNO-9006936.1 Signaling by TGFB family members 500985 362110 25490 25522 29302 296456 59086 24373 29381 310655 245921 290921 81809 297699 25366 79210 313477 81507 81810 292734 29200 25717 499508 59328 29591 29263 362800 85435 59107 50554 59106 310914 83837 289264 83838 367100 25378 25237 81516 24504 25387 140590 29530 690516 81920 29373 25671 500245 313757 500485 363455 361831 29417 25388 25196 25591 65205 24511 287155 54250 297893 29543 117273 300813 304758 100360427 64156 114208 116479 54281 24790 499929 363445 81918 25631 500715 24666 680111 83823 361178 29357 29610 84396 311061 81707 300802 116510 50522 50689 29192 292788 192255 81751 25639 116590 289231 100912032 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%10228656 Translesion synthesis by REV1 309812 288003 116468 25737 288414 100912032 50522 64156 316344 89809 59102 192255 313702 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-RNO-2514853.1 Condensation of Prometaphase Chromosomes 116549 305392 680089 362519 81650 362438 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-RNO-1793185.1 Chondroitin sulfate dermatan sulfate metabolism 50568 25181 316033 363513 500961 25227 29139 291577 291770 297554 500257 300757 304322 302302 301525 286974 365583 297865 314694 316533 361450 84468 404783 300993 25393 367166 24434 81651 294673 114122 DUAL INCISION IN GG-NER%REACTOME%R-RNO-5696400.1 Dual Incision in GG-NER 299112 171525 298098 288003 288651 362385 116468 25737 361580 304573 288414 294693 50522 291703 192255 302502 290027 59294 25591 100912032 304719 289758 64156 100362121 310707 502227 361181 89809 59102 361698 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%10231694 Regulation of MITF-M-dependent genes involved in pigmentation 361604 50645 360034 25017 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-RNO-9716542.1 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 361940 60431 78967 305614 64159 305457 307035 360509 290396 307562 81504 366608 314249 25614 312108 360500 305987 313845 81522 315992 362456 299857 305234 292756 308509 315121 29579 309168 25096 308875 498282 296323 309696 310833 306183 305938 63994 312113 362842 313438 308097 500287 306357 306279 246249 291694 688429 362893 314618 288093 307459 305156 367085 498130 313388 360840 314903 309362 305367 361617 303583 84014 303222 303501 295635 304282 29146 287746 500246 83620 84031 316639 300067 65032 307016 300186 304546 292279 302976 311450 29355 304530 311793 308021 25488 303653 114116 25097 114243 29611 314212 64303 688319 306871 299809 117273 313050 360678 362548 171115 306417 308968 25578 60377 29495 25513 362566 60664 25023 25437 170911 25515 50646 302855 291755 301007 29648 293497 363009 116685 116478 362938 362859 315829 363174 303553 64515 361029 306400 64678 681185 287543 297176 298594 366492 114592 289229 306506 25306 170845 360849 89816 308443 303037 498331 306464 310074 312077 679342 316213 296137 291441 314850 24669 299012 257649 312667 192207 257644 64041 305645 140922 287598 317252 307805 311191 114764 500545 25448 305270 363028 286993 54241 102555739 315164 114514 298850 681050 83836 295661 363198 304951 684439 287156 289150 192647 171086 361416 304477 497974 24874 295378 29431 363131 29432 363875 24255 65052 24511 83615 363445 315707 54350 81732 83709 65134 84009 287624 29433 114612 29489 287876 316369 289820 25594 361882 304109 64465 114559 25537 171549 81822 192348 54227 29491 316226 81655 116717 363059 297518 117259 360915 29448 29564 303251 297522 309922 288669 311860 64351 170824 300955 679934 286928 303811 117542 498798 309179 360854 299147 312754 83721 79249 84353 365407 79129 66021 294568 315348 81679 308666 362271 313024 116666 58823 682937 311030 81824 140734 58945 310519 117538 259242 306152 367901 84589 64665 83764 315840 117550 81634 293860 64630 81818 500569 25576 56011 25577 313017 171041 304813 315648 114004 298144 116670 24208 50689 363193 252902 24673 261736 24672 29528 117281 116590 85252 367915 313934 299331 117039 314906 304893 503165 81745 29753 24392 301252 83572 84427 56084 363235 25522 307511 64373 24244 170538 24680 306618 66013 317598 298404 287537 287418 310460 307098 120099896 246174 311647 363509 310635 310999 25270 78966 140898 361921 94266 309653 117020 303634 307170 301334 65183 363460 310192 114513 293024 100362710 687105 362648 362279 308761 29275 56785 64160 363031 83809 498174 309722 81531 304007 315265 503306 365355 305341 685357 79115 29681 297406 295588 297383 94195 83502 296060 310621 360942 65201 100360623 117955 315686 29417 367235 361813 54308 305605 24852 192277 310090 366170 498547 83724 303888 116547 679082 296162 313216 300030 171581 500929 300115 315732 309175 25230 690130 310013 300225 288057 303611 85428 300111 362988 291999 362993 171296 246314 293947 312640 360596 56010 79239 299145 313618 100363276 678766 313838 317296 689997 367902 114562 300838 29745 294429 311721 113960 287830 291000 83425 302783 84510 501099 363213 306004 292085 24829 306945 24828 117056 680498 81738 116643 685909 683983 680615 365877 308869 303175 301555 24264 64627 690795 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%10228132 DNA Replication 312046 313138 313479 299112 298098 292071 362385 312538 291927 307126 360621 304573 362304 301430 85241 59294 295052 114494 361698 289758 361831 303612 309441 89809 292058 307639 499914 290842 85472 288003 116468 25737 288414 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 84490 287772 292766 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 302783 117262 85492 294790 24829 306945 287984 24828 65138 94198 29673 50522 29671 29670 117056 29677 680498 29676 29675 685909 680615 192255 365877 81827 287280 83806 311078 303175 100912032 64627 690795 360908 301323 288532 316273 362607 24917 59102 295596 296178 29728 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-RNO-2428928.1 IRS-related events triggered by IGF1R 24483 29376 25443 170911 29348 25233 361388 81745 170579 170633 81504 84477 313845 363131 246273 84489 29516 25718 361992 83504 65052 66017 25444 25622 29349 54250 25513 25317 29369 25022 85243 29368 314850 170700 25467 116499 60662 60464 170583 24482 289625 25114 170582 79114 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 24605 293621 81504 24525 313845 25738 500985 83504 66017 25622 25444 29349 54250 25513 25317 29369 305539 83805 296072 29368 360903 170700 116499 60662 170583 64156 85385 79114 299236 83823 499308 29610 366205 170911 25443 361388 170579 170633 500526 114486 50522 50689 24673 192255 306141 24672 117281 116590 100912032 316213 314850 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-RNO-451306.1 Ionotropic activity of kainate receptors 24244 54257 29495 553106 58948 24407 24406 29559 298521 25252 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-RNO-5357786.1 TNFR1-induced proapoptotic signaling 688466 81859 498803 299827 115771 114210 312937 364386 63879 25625 60383 266610 306886 246756 24835 60371 290864 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins 25386 65133 294962 25521 25293 25132 25725 83579 81830 680149 58979 64199 114117 24400 79218 81667 24221 245986 29699 60449 25108 25240 293508 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-RNO-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 287454 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-RNO-9818027.1 NFE2L2 regulating anti-oxidant detoxification enzymes 117254 CO-INHIBITION BY BTLA%REACTOME%R-RNO-9927353.1 Co-inhibition by BTLA 25622 407756 116689 81504 TRANSLATION%REACTOME DATABASE ID RELEASE 97%10228352 Translation 682390 298700 64514 691947 299872 293427 288599 303831 288516 299899 171350 308306 293453 26195 26194 26199 26198 26193 26192 26203 26202 26201 81920 361831 312199 287119 293408 315769 294754 289508 498402 29565 64156 50522 192255 100912032 291434 81729 25347 29304 25348 28298 65136 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 81773 81774 303746 245981 295238 497860 293054 81770 309176 298517 291685 26200 293725 691531 293754 64640 363241 297799 171361 83789 361883 81807 300033 690345 81764 311903 363023 81765 301552 641452 81766 299628 64525 122799 497876 686234 81767 26197 29236 26196 81763 683519 315141 288916 294230 100361060 309140 100363539 58927 360594 500199 689284 299938 292758 287962 100361756 310856 295224 296551 54318 171061 29288 292244 29287 363646 29286 116650 29285 689432 124323 361473 361005 310653 29284 296302 362216 287772 29283 292766 297601 29282 56281 296709 309440 64302 287656 64306 29669 297459 29668 301250 301371 100360439 64307 299027 364656 29425 287302 100360846 293666 114017 296134 122772 117263 303685 25581 134486107 64360 29666 113958 294767 684304 303353 680747 365388 301352 24206 290850 297372 301240 498406 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 81827 83806 311078 116636 117045 292762 362952 192234 108348073 292148 300069 293484 171145 117019 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%10231336 Cristae formation 245958 140608 300677 171082 94271 245965 171069 29754 362749 641434 690441 171375 192241 65262 171374 26197 26196 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%10231072 CD22 mediated BCR regulation 100360919 308501 100913063 116689 81515 CHD1 AND CHD2 SUBFAMILY%REACTOME%R-RNO-9943411.1 CHD1 and CHD2 subfamily 302783 24829 306945 84401 687711 24828 680891 308738 245957 363064 100362099 293184 117056 361531 681031 680498 81785 100361269 81781 685909 192246 680615 365877 303607 313583 171365 300837 292019 680737 305479 290614 303175 291295 287768 299620 64627 295270 690795 84486 291794 304832 OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-416700.1 Other semaphorin interactions 310207 311384 296789 361537 313498 315711 24699 310630 363517 306790 PROTEIN LOCALIZATION%REACTOME%R-RNO-9609507.1 Protein localization 685325 266686 311446 303272 641452 25700 24792 64001 24451 64156 363445 65134 116718 25437 64460 310682 360826 83519 25270 25611 297570 65030 363516 311203 29725 305581 50522 171374 29534 84356 307170 282634 293991 29533 65183 308518 298689 288584 308718 25541 309532 291075 114027 63868 503049 80881 192255 117265 311849 85255 79244 50559 291922 297029 293067 65192 307081 24599 64526 360463 50681 84114 312703 84470 365571 24479 114209 113956 100912032 58857 79238 81920 85239 84029 680424 64461 498332 54226 64667 24686 361831 24248 314304 83842 83522 501072 361413 171142 116470 24803 INTERLEUKIN-37 SIGNALING%REACTOME%R-RNO-9008059.1 Interleukin-37 signaling 299827 25125 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-RNO-901042.1 Calnexin calreticulin cycle 50522 29144 64156 192255 64202 29468 100912032 FCGR ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230560 FCGR activation 25150 300678 100360919 25734 295279 289211 79113 25155 81515 83805 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-RNO-70895.1 Branched-chain amino acid catabolism 294972 63864 24513 301384 25618 29603 361215 81708 29711 25244 25014 140547 298942 293779 29611 312381 29592 64203 63938 361884 311849 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231390 RHOC GTPase cycle 317598 287537 314212 65134 83620 120099896 29681 60431 311647 78967 297383 25270 310621 78966 290396 140898 29355 312108 117020 64665 54308 307170 360678 83764 293024 361882 81679 309696 64678 306400 116666 25537 29528 300225 310074 25513 117273 299012 293947 307459 313618 498130 363031 306618 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10229140 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 50554 81516 116590 100912032 29417 50522 50689 300813 304758 100360427 64156 54281 24790 25631 362110 500715 192255 680111 361178 29357 PEROXISOMAL LIPID METABOLISM%REACTOME%R-RNO-390918.1 Peroxisomal lipid metabolism 65192 50681 114209 113956 363516 85239 84029 64461 307170 65183 308518 83842 25541 291075 83522 501072 171142 303577 311849 79244 85255 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-RNO-9675108.1 Nervous system development 313644 60629 29376 297518 24605 83510 289257 29423 293621 305614 64159 306628 24586 314251 308376 361597 81504 24525 310207 25614 25150 116696 84477 313498 313845 117523 361364 308458 290905 362572 301252 266729 288669 84427 293508 65208 25622 310630 116690 54319 25513 85243 84393 29751 140908 64373 24716 24718 60664 85385 24680 312477 286908 116671 171119 498898 25136 300955 316639 170911 361388 78966 29302 360854 366508 296456 171574 310192 246331 116563 306400 116743 366492 81824 170851 314850 25751 24553 83800 54241 314641 295378 25738 29431 59312 29432 363875 25311 24511 140670 685269 498416 81515 117273 83805 362993 364686 84357 312213 81650 79114 140694 81732 311384 50687 24410 315615 83709 24699 24329 686310 58960 24338 84009 316539 300802 502694 287989 299737 25676 312275 81687 116683 310643 29433 50689 309280 84358 81686 25454 29192 315711 79208 360546 316009 171287 292788 94268 306636 298528 25453 287876 316369 312279 289820 361882 501203 81751 289392 304109 24408 361537 64465 116549 114559 25615 25537 84027 29210 81822 66023 83841 54227 116590 289231 29491 306790 65046 81521 296789 25525 361568 25418 25415 25417 299331 25416 363517 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 81751 24890 29192 292788 300802 24918 289231 363014 83805 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 97%10231288 ATF6B (ATF6-beta) activates chaperones 89842 CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions 24894 24299 24895 29277 25086 171522 54246 308445 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-RNO-2032785.1 YAP1- and WWTR1 (TAZ)-stimulated gene expression 304514 301164 363014 308582 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%10229176 Cdc20:Phospho-APC C mediated degradation of Cyclin A 117262 85492 54237 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 64515 83806 297176 295052 311078 287772 292766 100912032 29669 29668 114494 29425 64156 100360846 361831 117263 25581 29666 303353 365388 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229318 FGFR1b ligand binding and activation 25443 54250 170579 25317 79114 170633 83823 29610 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 97%10230624 Abacavir ADME 100363253 24904 29504 29503 24172 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-RNO-9933939.1 Formation of the polybromo-BAF (pBAF) complex 368001 296732 83833 361374 301020 361925 361825 292404 287876 293514 303518 LXR-MEDIATED SIGNALING%REACTOME%R-RNO-9024446.1 LXR-mediated signaling 58851 497941 365755 302711 313210 84578 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10229498 AKT phosphorylates targets in the nucleus 84482 361696 29414 79240 25233 24185 302415 294515 313558 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%10231060 Resolution of D-Loop Structures 85482 289777 287634 192218 290805 293489 305000 308755 306734 300711 302982 360588 497856 302953 64012 499870 293678 497672 498265 293452 64557 102551085 303194 291787 498119 499966 689055 64046 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%10230506 Cysteine formation from homocysteine 24962 24250 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism 171458 65038 50557 497197 24655 116699 282636 688862 308451 171088 80849 500709 94267 81677 294292 140693 29688 365382 24654 290651 316376 114633 297522 54260 25738 83523 29337 252899 25031 85240 24244 294429 287830 291874 362281 85238 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 245922 81738 683983 53372 25497 499974 54259 306808 50560 59268 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 97%10229018 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 60350 299827 29260 293624 25622 287545 252961 362788 100912032 364867 448830 50522 292892 246294 64156 192255 363328 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME%R-RNO-111469.1 SMAC, XIAP-regulated apoptotic response 64026 25402 100360940 63879 287606 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231164 Regulation of PTEN stability and activity 50557 117262 85492 63879 25233 287984 24185 65138 94198 29673 50522 29671 29670 29677 291171 500572 29676 25489 29675 310306 79209 192255 81827 116549 83806 287155 311078 308051 287772 292766 291999 100912032 29669 29668 296988 29414 29425 64156 100360846 117263 25581 29666 81650 303353 365388 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230390 Estrogen-dependent gene expression 83830 289561 363026 292778 192218 64466 60421 117526 301164 83503 117017 304157 498109 363633 301128 362110 301252 362809 260321 25154 500569 297893 84424 85471 50662 361391 60349 81647 25098 314322 171068 302783 24829 306945 24828 24516 117056 680498 685909 680615 365877 303175 311764 24890 64627 690795 288588 500633 316123 299331 83828 690966 24919 361365 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-RNO-2559580.1 Oxidative Stress Induced Senescence 302783 24829 306945 24828 363855 313048 25272 50522 50689 24516 289014 117056 680498 363630 116484 307151 25164 685909 315994 313038 494444 680615 192255 365057 309626 294917 365877 114495 310258 303730 315136 116554 24842 501403 303175 50658 116590 114483 688041 94201 100912032 304798 64627 690795 64156 83712 314322 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228304 Propionyl-CoA catabolism 687008 291939 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 97%10231140 Signaling by MET 24605 293621 287942 81504 24525 303517 25614 309816 691517 313845 500985 363875 311331 56084 360658 292770 29135 50866 24511 25622 25513 171337 83805 361396 64156 364686 84357 313388 85385 360606 170921 25532 81922 313474 170911 361388 25125 50522 498798 192255 79121 81921 116743 311030 100912032 295347 54245 24553 24697 24446 312574 296121 117063 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%10230450 Collagen formation 367313 678743 499431 84352 363158 290637 84032 363458 288583 50654 25335 306628 81687 300341 25697 290905 301012 85490 315071 24914 25506 287899 29569 353303 554172 314981 312115 289081 60379 25681 685612 29345 304021 305253 83470 288016 365460 64367 290350 309380 294279 25412 25654 315714 362584 315979 114200 362285 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10229574 NOSIP mediated eNOS trafficking 24600 292894 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%10230212 Interferon Signaling 361810 301442 24245 24246 89829 171140 25622 25498 292892 170538 500538 100361294 116689 54237 300955 305896 362678 362050 298693 691105 54287 25125 100911527 306204 690894 114558 24667 310968 300772 63880 499155 81746 24472 304266 304859 312754 291978 24649 502959 25489 24481 502320 303742 120103159 120103158 314172 84472 171164 298205 311430 686326 29219 24963 298210 501552 60460 288264 311130 363006 24468 24697 117063 25400 25738 170897 313017 64511 25318 64156 54281 116725 360697 24703 116465 315648 25712 24514 309295 306231 359726 304545 50522 50689 84351 24673 287876 192255 114495 24672 24842 295704 117281 81822 116590 100912032 312688 309361 24917 81635 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-139910.1 Activation of BMF and translocation to mitochondria 116554 140734 246142 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%10229014 The fatty acid cycling model 25708 24860 54315 85263 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%10228892 Amplification and propagation of coagulation cascade 302470 24946 315272 79224 691992 29366 25268 502858 25259 65051 304917 116727 29243 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10230054 Intracellular metabolism of fatty acids regulates insulin secretion 114024 113976 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 97%10228332 Glycogen breakdown (glycogenolysis) 24244 678739 29353 361377 140671 367562 64035 81675 307091 362029 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-RNO-9958790.1 SLC-mediated transport of inorganic anions 29502 315311 81826 503568 114629 246234 29440 84484 360670 295645 117267 58980 297910 297386 304784 24780 301010 24781 117955 691209 29501 54300 308069 83629 171373 25548 84395 24779 114613 266612 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%10228672 SLBP independent Processing of Histone Pre-mRNAs 689116 171365 680737 298075 100362099 681031 687711 366468 501688 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10228810 Ion homeostasis 89821 25390 116601 25400 25679 25391 64672 81678 24211 29693 24212 24213 29600 63847 294141 63848 29599 362013 29715 29598 312981 29248 58971 64190 308405 116831 29639 29132 140447 58950 24245 24246 140448 24598 59299 171140 25262 83535 25560 24244 689560 361618 25650 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%10229222 Polymerase switching on the C-strand of the telomere 307798 307861 59294 364996 288003 116468 25737 288414 85241 289758 301323 303238 89809 290232 297758 294025 361698 500054 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%10228752 Cytochrome c-mediated apoptotic response 64026 50689 78963 295961 58918 25402 100360940 63879 25309 116590 690675 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-RNO-8932505.1 DAG1 core M3 glycosylations 316091 291212 306549 84430 688673 114489 MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy 364419 29564 60445 300711 64670 679886 312647 299827 360827 361916 24855 365191 114558 83529 83532 83531 299514 266601 298575 685620 363254 300075 308416 304017 140734 81920 58945 282834 192647 641452 56816 64862 363131 24255 363836 65052 678769 313391 171415 300240 362164 316640 83805 117287 363720 65248 59319 305482 360682 363278 686505 308846 64156 303554 689161 304579 116725 302559 312634 305831 81650 288498 312927 499973 64562 287873 50522 246294 252902 29489 58974 288731 362245 361321 363442 192255 365601 25520 116549 83803 308869 310091 312703 298514 64226 295357 373545 113894 100912032 297960 26954 117044 117043 362045 56718 360776 81655 PROTEIN LIPOYLATION%REACTOME%R-RNO-9857492.1 Protein lipoylation 293453 365314 81654 29611 29189 171133 299201 316342 305348 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228522 Triglyceride biosynthesis 79223 362732 296130 316737 681211 29653 84497 252900 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME DATABASE ID RELEASE 97%10231096 Gap-filling DNA repair synthesis and ligation in TC-NER 366163 84495 299112 171525 298098 289561 288003 245976 292778 288651 362385 116468 314061 362479 497967 360471 25737 361580 306274 304573 288414 294693 83503 117017 50522 291703 498109 363633 192255 302502 362394 59294 100912032 288588 64156 289758 266713 246216 502227 361181 89809 59102 690966 361365 84389 361698 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 97%10228572 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 140547 24158 113965 171155 170670 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%10231562 Oleoyl-phe metabolism 498226 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%10229692 Biosynthesis of Lipoxins (LX) 287454 79242 114097 29624 25290 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 97%10228220 DNA Double Strand Break Response 316794 85482 192218 114212 287927 25573 313539 361815 301442 301128 300711 690043 302502 65179 292172 311860 296099 64012 287772 292766 368002 29669 29668 29722 29425 308669 64156 100360846 100359714 293719 116725 117263 289468 25581 29666 361181 303353 365388 362827 117262 362704 85492 306257 24829 306945 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 116554 24842 83806 311078 303175 100912032 497672 64557 156826 64627 290997 64046 290631 502935 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation 81745 641452 100360919 307366 287772 292766 81515 29669 29668 29425 64156 100360846 116725 117263 25581 311245 29666 303353 309295 365388 117262 85492 287984 313121 65138 94198 29673 50522 29671 84351 29670 29677 29676 29675 192255 81827 287280 83806 311078 308267 361765 100912032 317546 81736 25493 309361 361831 303024 83477 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10231502 NOTCH4 Activation and Transmission of Signal to the Nucleus 25578 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-RNO-8854521.1 Interaction between PHLDA1 and AURKA DEGRADATION OF AXIN%REACTOME%R-RNO-4641257.1 Degradation of AXIN 117262 85492 287984 65138 94198 29673 50522 29671 29670 79257 29677 29676 29675 192255 81827 29134 83806 311078 308051 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 EXTENSION OF TELOMERES%REACTOME%R-RNO-180786.1 Extension of Telomeres 306264 288003 116468 290805 25737 288414 85241 287432 297483 170944 499709 367645 308755 691534 301965 362288 287273 303238 290232 297758 294025 500054 307798 307861 364996 59294 84490 295052 171121 114494 289758 309144 301323 89809 59102 361698 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%10228424 Inactivation, recovery and regulation of the phototransduction cascade 307401 499132 259274 317498 316218 85259 363143 291318 301233 29481 140936 64370 25539 116556 59077 79222 299521 81760 24717 83579 680149 64511 24244 25318 289878 688297 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%10230678 Cohesin Loading onto Chromatin 290577 304218 313304 63996 290668 305343 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%10231772 Transcriptional regulation of multiciliogenesis 100360427 362675 498102 299979 298555 313993 361178 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-RNO-69656.1 Cyclin A:Cdk2-associated events at S phase entry 25233 24185 362485 499655 366275 295052 287772 171102 292766 94201 308937 29669 83571 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 58919 117262 85492 24708 294790 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 171103 100912032 307585 29414 266713 84389 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%10231610 Regulation of CDH11 Expression and Function 81679 311163 24790 84353 362850 300289 84407 303068 SIGNALING BY FGFR4%REACTOME%R-RNO-5654743.1 Signaling by FGFR4 24605 293621 170911 361388 500526 81504 114486 24525 50522 50689 313845 25738 24673 500985 192255 306141 24672 66017 25444 25622 117281 29349 54250 116590 25513 25317 29369 100912032 316213 83805 29368 314850 170700 116499 60464 170583 289625 64156 25114 170582 85385 TCR SIGNALING%REACTOME%R-RNO-202403.1 TCR signaling 50557 81745 641452 81511 25738 29337 29431 29432 366962 307366 363577 287772 25513 292766 85243 295338 294269 29669 300678 29668 313050 25300 29425 24981 64156 100360846 25710 24986 24932 116725 117263 25581 311245 29666 315707 303353 309295 365388 117262 24699 85492 300955 170911 287984 313121 362491 65138 94198 29673 29433 50522 29671 84351 29670 29677 29676 29675 192255 310727 81827 64019 287280 83806 311078 308267 361765 100912032 81736 25493 309361 499537 361831 303024 54259 83477 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 97%10229380 Sterols are 12-hydroxylated by CYP8B1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) 29376 24605 293621 287942 81504 24525 313845 140670 56011 25513 85243 117273 59109 310738 85385 315648 81771 117269 501099 58960 170911 114486 50689 289014 363193 24673 315994 315305 116478 314612 501560 116563 24672 116743 300980 117281 116590 170851 314850 29622 65046 117535 25467 295347 314910 114090 116663 300078 60587 54245 83800 54241 UBIQUINOL BIOSYNTHESIS%REACTOME%R-RNO-2142789.1 Ubiquinol biosynthesis 308453 498332 365592 498909 296128 366013 304542 299195 360887 25249 313521 29309 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-RNO-9840373.1 Cellular response to mitochondrial stress 27137 298203 54318 114766 299027 298282 296302 307480 RAP1 SIGNALLING%REACTOME%R-RNO-392517.1 Rap1 signalling 295347 313644 25578 361710 24703 54286 29434 56011 59326 171337 361714 293508 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-RNO-1299287.1 Tandem pore domain halothane-inhibited K+ channel (THIK) 64120 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism 315219 116593 81656 313574 287368 65135 312373 289801 295620 SIGNALING BY FGFR%REACTOME%R-RNO-190236.1 Signaling by FGFR 689116 298075 289561 292778 24605 500409 293621 362950 307810 361655 81504 83503 24525 117017 498109 313845 363633 25738 29578 500985 84489 83504 64200 66017 25622 25444 29349 54250 25513 25317 29369 25022 305539 83805 296072 29368 360903 170700 116499 60662 60464 170583 289625 64156 25114 170582 85385 79114 299236 83823 499308 29610 366205 170911 25443 29348 361388 170579 170633 500526 64535 499349 114486 50522 50689 24673 192255 306141 24672 140931 117281 116590 100912032 316213 314850 29497 366061 288588 316123 690966 361365 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69580.1 p53-Dependent G1 S DNA damage checkpoint 117262 85492 114212 287984 65138 94198 29673 50522 29671 29670 29677 29676 362485 29675 300711 192255 81827 24842 83806 295052 311078 287772 292766 100912032 685474 311575 29669 83571 304798 29668 360860 114494 29425 64156 100360846 117263 25581 29666 303353 365388 BIOLOGICAL OXIDATIONS%REACTOME%R-RNO-211859.1 Biological oxidations 25331 308190 24886 25527 291394 63867 58953 246232 58962 83472 156275 24421 24423 24422 81522 24424 24172 94199 298079 24426 360268 361510 310201 301252 25750 246245 310848 29443 361637 78959 29539 362809 140925 290401 24912 297433 81869 494499 312952 25283 116632 116631 29487 300981 300983 266685 501907 291984 286954 362196 288617 25458 501110 312495 113992 309465 690050 64352 64473 293653 25035 408206 116568 295037 114700 25260 683630 57300 171451 100145871 24902 681913 303953 29277 288517 25279 296259 25086 25315 24296 291084 24297 171445 499689 29473 26760 116684 688536 83783 498940 499353 293779 290681 286989 503103 360994 29566 171072 353317 64305 29739 171347 246263 24307 25375 290623 304078 266674 290947 310903 24894 171341 24299 292915 502969 84493 298423 24895 286904 313375 24306 171522 299566 503122 54246 171178 50549 25256 25429 266761 301517 25426 25428 79122 25427 29189 313786 83724 25242 362782 266682 25243 60351 29680 498999 80773 252931 24188 113902 24861 494500 297029 308652 24267 308445 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%10231526 FOXO-mediated transcription of cell cycle genes 84482 50554 25631 302415 294515 24370 29357 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME%R-RNO-73762.1 RNA Polymerase I Transcription Initiation 288651 361580 306274 117526 313048 294693 83503 291703 498109 301246 100362346 304714 361784 360893 361420 310614 361724 297893 290669 362834 64520 313245 117535 680493 25574 362728 83582 690450 83581 266713 83712 502227 690966 84389 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 97%10230032 Deadenylation-dependent mRNA decay 364624 294975 293408 300045 303831 361109 307850 171350 688288 117045 363064 360629 500305 294595 297455 266605 500988 360760 679140 366017 361399 361736 498934 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse 64373 316009 25537 78966 117273 306790 362993 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-RNO-433137.1 Sodium-coupled sulphate, di- and tri-carboxylate transporters 503568 58980 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-RNO-8939246.1 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 50662 361391 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase 366381 292588 293155 296368 361389 288671 290875 305420 360643 295052 287772 292766 29669 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 117262 25203 85492 54237 292263 25515 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 64515 287280 297176 83806 311078 361765 100912032 361831 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability 81679 311163 24600 296648 25233 64226 81745 24185 24244 29433 295378 29414 56718 315189 29431 310131 29432 84353 363875 299331 246273 361992 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%10229946 ADP signalling through P2Y purinoceptor 1 25265 81666 81662 83805 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%10231602 Ribavirin ADME 100363253 25368 353307 60423 63997 140944 290029 24165 311422 83782 191575 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-RNO-373080.1 Class B 2 (Secretin family receptors) 117064 64680 25321 25026 25029 171519 64199 56820 25024 60432 79218 316137 29555 361383 29446 245986 24241 498791 399475 60449 58959 294962 116506 24695 81779 24875 81648 25040 58965 58966 83579 680149 29151 24476 24953 24694 58979 24769 114117 24400 81667 25051 81753 24166 56813 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 97%10228570 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 140547 64304 113965 171155 170670 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%10228970 Mitotic Metaphase and Anaphase 364419 363059 29564 25573 297522 301442 83572 679886 361916 290577 304218 313304 25203 63996 684771 54237 305343 25437 25515 114087 365191 94266 309179 299147 312754 29648 116685 363174 64515 681185 297176 298594 114592 170845 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 307805 311191 361831 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 282834 83836 295661 363198 682908 304951 64158 684439 500377 289150 117104 361416 307833 304477 246118 500363 300218 498736 65201 316531 307351 366381 291081 84509 292588 313478 293155 296368 679312 361389 296554 288671 29213 290875 362700 305420 360643 500929 287772 292766 363720 29669 29668 29425 64156 100360846 117263 25581 29666 315648 303353 294429 365388 287830 291874 246772 363481 113975 117262 85492 64193 292085 295692 292263 117021 362335 287984 287624 65138 366016 94198 29673 287873 50522 362557 29671 29670 252902 29677 363193 29676 29675 29489 81738 24673 362548 683983 192255 81827 24672 83806 311078 117281 100912032 85252 81655 24917 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%10230644 Signaling by NOTCH3 81751 29146 24329 56761 300802 289231 291999 100912032 50522 25313 29192 29650 64156 292788 311332 84010 500538 192255 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-RNO-205043.1 NRIF signals cell death from the nucleus 81751 300802 289231 113894 100912032 50522 24596 29192 64156 310738 292788 362548 311245 192255 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-RNO-69560.1 Transcriptional activation of p53 responsive genes 24842 685474 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME DATABASE ID RELEASE 97%10231458 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 114097 499689 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-RNO-3214841.1 PKMTs methylate histone lysines 362093 313048 680498 294924 100366024 365155 362831 689954 306764 310638 308345 361688 100359816 290831 498295 291844 299295 289372 364785 302553 100362634 102550344 689820 689883 688041 81736 64627 304794 83712 315606 309452 290829 309001 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation 25493 84351 54226 309361 25742 287707 309452 309295 81736 PTK6 DOWN-REGULATION%REACTOME%R-RNO-8849472.1 PTK6 Down-Regulation 366275 24697 296472 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 97%10230470 Synthesis of PE 316737 310773 29367 89841 360843 29194 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling 84405 171334 171333 680609 25506 85491 25125 155140 290655 29144 689932 100361294 24514 365368 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-RNO-9968551.1 Regulation of GBP-mediated host defense 304266 24649 313017 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%10230828 SUMOylation of RNA binding proteins 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 25573 65274 113929 297522 301442 245922 499417 81738 307151 683983 60373 313038 53372 25497 309626 499974 310258 303730 501403 287662 117282 294429 HEMOSTASIS%REACTOME%R-RNO-109582.1 Hemostasis 50693 25441 682967 293886 25692 94168 24605 289316 25666 293621 25544 89817 308291 89807 360509 497978 24816 89805 81504 25673 24525 499913 366608 25614 25528 24795 25150 114095 305987 314930 313845 315992 311795 313611 25651 309684 84491 300519 293692 307396 29436 81683 246328 308875 299909 102554884 309207 499099 25266 260320 63836 362248 60325 366960 313438 293676 294643 113947 25373 364206 292661 313388 50719 314615 360918 25524 25083 25087 81515 117273 83805 313050 24482 116479 24703 24514 246358 29715 29409 140447 140448 140928 63885 25523 24599 24598 301512 24600 81743 171115 25262 54286 191569 308899 54245 54259 25578 25216 24174 24175 25265 64803 25622 25513 85243 60664 85385 116689 81803 81804 25023 170911 25155 59086 81809 25717 25387 24483 81739 29659 116601 192647 114115 113995 25679 25505 25391 81678 29693 25041 29600 295378 29665 81511 29599 100360919 29598 25738 60395 29337 24189 25388 363875 29636 116498 170924 24511 25081 304805 25518 65200 80878 315707 25027 116726 83509 25650 84551 360606 307811 50687 25390 24825 298947 497931 113886 497932 287624 294286 287876 24186 64465 25615 171549 24854 295703 316226 363288 500709 85248 315272 84393 313254 303575 24648 314473 289309 308637 300158 29302 114111 89811 309179 299147 360457 296456 312754 83785 302470 25414 24946 691992 295347 502858 25259 116727 29243 303659 54225 24697 24446 293502 79113 315740 117548 117550 81634 289397 293860 64633 64516 500569 297893 361308 60327 79224 29366 171291 25268 65051 25313 304917 289055 171041 84590 315648 499271 24617 24791 50689 363193 24673 25599 24672 246209 117281 116590 54226 314906 289168 81745 24185 64199 286924 79218 353302 245986 60449 84427 293508 294962 309523 25521 25686 25643 25725 83579 680149 58979 64373 24244 170538 114117 24400 85471 81666 81667 24681 29699 24680 29340 81662 81664 29691 303634 81613 29300 691984 171517 116673 24771 362558 317322 25236 58920 25592 360942 50692 316531 363104 24366 24367 685269 29434 59326 171337 361714 24936 85253 309609 366998 140914 24944 58844 305021 54248 56782 192249 361196 54249 363015 81749 29364 54254 500152 688705 100359512 64188 300338 65037 25246 498299 445442 29254 25406 686539 29583 24153 81778 291085 116510 29476 363195 306761 305795 305679 307986 360922 26956 24786 117056 116635 54404 680498 171120 691504 114203 312159 360950 140656 171154 306608 296488 24614 171577 56611 29186 25172 24628 54320 308995 296269 245955 315989 315509 25159 304983 300266 64025 245962 500336 81814 684555 81821 116662 50567 114124 89843 362825 140866 100361138 140594 309186 301229 681544 499951 293628 363930 83580 361512 619374 312562 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-RNO-1855204.1 Synthesis of IP3 and IP4 in the cytosol 65038 85240 50557 85238 497197 24655 308451 171088 500709 81677 140693 24244 24654 114633 54260 25738 29337 54259 25031 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-RNO-9623433.1 LXRs regulate gene expression to control bile acid homeostasis 58851 INTERLEUKIN-17 SIGNALING%REACTOME%R-RNO-448424.1 Interleukin-17 signaling 117269 500133 363520 313121 362491 363855 25272 50522 50689 84351 24516 289014 363193 24673 315994 192255 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 100912032 317546 81736 116663 64156 309361 60587 81647 303024 116725 314322 311245 315648 309295 81771 DIGESTION OF DIETARY LIPID%REACTOME%R-RNO-192456.1 Digestion of dietary lipid 25702 25680 117554 50682 84028 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 97%10228310 Metabolism of lipids 50557 114089 25096 293453 50671 307428 298504 293173 500132 306460 246074 171410 85254 171402 171400 170465 362058 363159 25329 170570 687008 116723 295674 54398 364134 100363074 500292 690610 29470 295458 294255 304474 191576 499570 64677 404280 364298 291939 287467 25511 25756 25757 288322 140547 287115 367112 24873 359725 25097 361802 407765 287366 266604 114561 116740 140544 287533 311849 60581 81925 117543 80841 301131 140607 81919 301024 58924 290843 24950 360753 314553 360521 301120 192260 362702 290223 315973 64828 683713 25014 50555 302425 289125 293620 305935 300129 25598 364901 291699 63888 361401 362972 24230 289021 300108 361895 498728 84575 361659 26759 681694 24450 89812 287380 25557 361676 116700 361433 65984 117243 691478 300783 619561 291541 25524 25413 100911581 304208 361694 353229 680115 499174 84013 366065 79131 360618 25062 500624 361467 312382 83512 58970 363521 24565 117182 296188 246237 80773 296851 361213 286936 314438 314800 100270678 83626 83505 310667 500651 680971 170897 295417 366697 678749 296623 366984 307855 308584 310849 367786 25288 360833 25045 25287 308589 60418 310663 113965 171155 60666 170670 29411 309449 305291 365984 365865 291211 170919 29510 293688 25747 25675 311617 29637 282584 619549 362249 81726 24159 298298 29726 81727 94340 29540 305150 29230 25363 308100 311821 309262 679520 310645 64822 117278 306490 114100 310508 296732 83791 305166 81681 64191 78968 300095 140910 29580 89784 366196 54259 65038 25513 85243 60664 316737 81747 170911 116482 364629 116720 366508 289456 116463 691018 25322 296972 79243 64310 498331 361632 259221 363131 58978 266682 84024 312086 361992 252931 24192 65052 140668 63865 298947 497931 497932 29725 362360 298369 502348 24777 296461 79111 25440 308518 311129 25541 291075 246211 303497 303879 503049 170698 83569 85255 79244 50559 24186 309527 300790 65192 192242 50681 84114 84470 140940 114209 113956 79238 85239 84029 64461 314304 501072 171142 303577 89842 305419 288762 114554 116699 307842 309855 316457 80849 171088 310155 25573 29216 499417 94197 362827 300147 114024 113976 83842 83522 314641 114101 360426 312689 64633 305482 312634 79223 362732 85238 296130 681211 29653 25532 84497 252900 363494 114104 303729 25227 24158 311013 24470 316642 682974 84018 29624 83537 29632 303631 299270 117185 25146 25116 289687 360348 94338 315222 25117 289014 24800 365619 310326 684536 362409 307404 84431 497991 362039 691905 29354 294324 24913 309419 29692 308309 295631 298579 29526 29359 297694 296128 291283 307092 25682 307096 363026 24886 288025 289733 25527 293711 25526 314075 84578 59103 29224 296048 58962 311341 362434 313997 498741 94199 361266 364773 310848 498790 362809 498789 365755 302711 316039 361686 85311 171516 291984 140868 191574 116568 114700 287454 29527 29328 79242 81639 29277 114097 25279 25086 299732 24296 24297 499689 25270 65030 363516 25290 307170 65183 29566 24307 290623 266674 287424 287425 502969 24404 298423 286904 313375 24306 171522 299566 192259 503122 50549 300757 301525 362275 64442 64445 294673 316033 500961 65196 25429 84509 301517 25426 25428 79122 25427 29189 313786 83724 362782 60351 29680 310773 29367 89841 360843 29194 24360 499210 286896 313339 301118 317296 246115 81650 309147 29254 64562 64304 117099 366463 690163 312947 116549 373545 80848 24917 363024 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%10230718 Processing and activation of SUMO 25573 690244 308384 103689978 78973 304132 301442 690251 499417 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-RNO-446203.1 Asparagine N-linked glycosylation 289257 305614 64159 79117 29564 314251 252889 93646 314030 116696 297522 117523 295461 308458 294010 292074 289994 290994 54400 171121 293719 24648 64462 89868 290659 64351 361705 407765 29183 301012 24506 24505 287427 683007 114023 302470 304978 116666 117513 100360302 29167 140734 58817 58945 364901 501550 60355 690252 367073 100912115 299075 60384 300674 83505 291990 25423 299121 50592 309010 246310 313139 311204 305291 365984 64528 171049 64156 309144 84599 81726 287275 287276 25407 94189 680465 361207 298071 310935 114711 361577 24210 291095 501167 360475 316642 300668 362547 50522 293456 315212 117185 311530 300089 309451 293587 252902 302915 29403 303692 25280 300888 301155 300741 287920 246117 299346 192255 313231 79120 298541 311847 29758 295051 288525 294400 25128 363103 304860 362031 310411 100912032 309678 300743 29144 56042 29468 362237 362599 306264 503165 29631 363109 297393 498272 297417 498486 360518 302972 252929 81759 84428 64202 361014 298012 64310 140673 303923 362275 363040 64442 64445 316033 192243 313536 29640 494342 296394 362924 502017 65196 24375 291325 140808 25478 25197 303100 308757 65271 362625 367252 295319 25547 29582 299756 81519 94273 140568 432392 64154 117263 362162 361073 54350 315059 24827 65134 297428 304290 58842 363136 299850 81754 29489 116643 252853 140940 65165 685144 81655 690961 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 97%10228602 RNA Polymerase III Transcription Initiation From Type 3 Promoter 301246 294687 114205 311487 310685 361102 117526 685465 690254 83503 306012 304204 362537 306542 498109 171068 690966 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229608 Thyroxine biosynthesis 65162 311374 266807 308129 29475 25430 79107 116700 114613 302899 25653 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-RNO-204998.1 Cell death signalling via NRAGE, NRIF and NADE 29753 295378 313845 25402 363875 64156 310738 311245 306618 66013 500608 317598 298404 287537 287418 310460 64639 307098 84009 120099896 246174 311647 300802 363509 310635 310999 78966 140898 64314 361921 307398 50522 309653 117020 24596 303634 29192 301334 117089 295449 363460 292788 310192 64547 362548 114513 293024 100362710 192255 687105 362648 81751 304109 116554 114559 289231 29491 113894 100912032 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%10230752 DEx H-box helicases activate type I IFN and inflammatory cytokines production 310461 304859 293624 301059 309452 81736 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-RNO-74160.1 Gene expression (Transcription) 689116 311796 298075 305455 679203 25309 302415 313558 24370 60331 84482 26195 171335 654441 303393 26198 84683 25329 116723 94194 688386 681024 100188937 54322 364298 360229 24873 25282 29445 140607 24398 102555170 690675 252934 192268 288588 266713 291773 316123 317256 502227 83828 690966 161452 361365 81673 84389 170844 83830 171152 309638 289561 292778 288651 288533 89812 373541 293345 294018 361580 116700 303918 117526 294693 83503 117017 291703 498109 363633 287571 362485 83805 25747 303518 297867 296732 83833 361374 301020 361925 361825 64314 294687 114205 311487 310685 361102 685465 690254 306012 304204 362537 306542 113898 293058 29386 252860 102556092 192350 58839 102553962 296102 259241 58850 58853 246299 308986 102547287 65035 25578 686781 306571 305120 686774 58983 140942 108348224 498160 363292 83826 690728 102555083 54278 365224 295448 362095 286979 296653 100912096 303281 308971 292064 299810 303132 282845 102548695 286996 114510 293044 29338 102549410 290744 303226 306977 315210 102555289 24413 25622 100158223 685619 102546572 307839 102547413 100909569 299694 299210 306998 266734 313131 102550851 314586 192178 315427 287361 691153 306966 24522 25735 78972 308911 300197 116671 306816 365192 306817 81808 313596 25203 245980 54237 116698 685539 266787 102546648 288514 298558 298681 289307 499874 499994 83474 367034 266774 311567 298688 500108 502894 114491 171355 362813 303774 59086 305837 301119 64028 683593 81812 683469 313219 291705 360764 100360287 24377 680200 361988 360896 293625 102555672 114592 287076 156726 311591 314862 314621 84469 120095871 289382 316810 314993 313777 24484 287094 24577 310233 297065 691379 498952 300320 293701 102556967 100362678 297066 312303 25672 498945 360589 117254 291534 291772 102553002 288003 25405 311546 116468 84385 314818 300782 494339 25737 499900 81807 500855 288414 25533 114490 25697 309002 29175 282844 305000 313978 64525 297093 292804 685925 293849 85265 308362 688328 309457 252917 100364132 691610 291164 311414 170955 690895 679713 497923 361487 100362083 246334 29657 117274 60661 680717 100364568 102553866 100365779 306261 362358 308561 308320 308326 365744 308322 246279 311613 300813 304758 681740 100360427 313914 114208 691422 24790 252924 499929 60571 363445 120093538 25631 50659 500715 363227 24666 100365683 680111 499068 362272 361178 29357 286917 84396 361057 690559 363481 246264 303539 100362170 687001 297453 689844 362981 56761 310405 363287 679028 24942 84580 303101 363064 293184 361531 81785 287876 497672 64557 304277 363924 303194 291877 315969 84486 64046 308582 304514 79240 85482 192218 114212 290805 311670 299256 299811 685055 310034 289582 25573 308755 306734 301442 300711 297627 311860 295052 360588 497856 64012 294800 368002 114494 498411 100359714 291787 100361529 140583 681062 170824 140923 134478826 296648 24855 116697 683927 315189 310131 84353 365407 314417 686980 311166 50554 298533 311130 81516 299284 363006 689883 680155 366975 690516 81920 313757 361831 304832 25233 65261 366468 501688 116484 25576 689820 56011 297893 25577 313017 290270 309757 50662 361391 64156 288563 315648 24208 295384 444984 24708 362479 360471 306274 50522 50689 24673 192255 497991 25664 619436 114495 83516 310958 312451 289881 100359816 24672 291567 300837 300367 293500 498112 300206 291440 117281 100362634 102550344 313323 116590 207118 306030 100912032 311575 314964 299569 117535 360581 299607 24890 29414 287475 303403 497941 299180 24705 311468 26295 362414 685072 293488 317343 310194 316209 59102 360642 362224 309001 316328 25682 58851 314704 290939 299905 679693 115771 64466 81745 24185 60421 84578 301164 60445 29753 25149 502988 362110 294515 25154 365755 302711 307511 25498 685474 140908 304798 83571 83574 85471 60349 171068 301246 100362346 304714 361784 360893 361420 310614 361724 290669 362834 64520 313245 680493 25574 362728 83582 317399 690450 83581 301513 291841 287249 316034 29619 306492 363603 83722 312227 363221 58936 295707 29417 84509 83724 25242 365155 25243 60351 25591 289372 302553 287772 292766 65248 287662 29669 29668 56010 29425 100360846 54281 83712 117263 25581 29666 81650 315606 303353 365388 290829 58919 302783 117262 85492 64562 24829 306945 287984 24828 687711 65138 362093 313048 94198 293615 29673 304809 29671 29670 117056 100362099 29677 64033 681031 680498 691504 29676 362675 29675 307151 685909 25193 313038 680615 304690 309626 363014 365877 25720 310258 81827 303730 171365 25520 25172 315136 116549 680737 83803 681178 24842 83806 313507 311078 500453 308869 361944 84027 310091 25159 298514 501403 303175 64226 300266 171046 295357 114483 373545 688041 297960 26954 117044 117043 64627 362045 690795 56718 304794 360776 HEME BIOSYNTHESIS%REACTOME%R-RNO-189451.1 Heme biosynthesis 25748 65155 25374 289219 304024 691853 309391 309070 312382 361338 24186 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-RNO-189085.1 Digestion of dietary carbohydrate 497039 289032 113901 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230818 SUMOylation of SUMOylation proteins 287830 291874 362827 362281 113975 292085 295692 117021 362335 366016 58958 362557 25573 65274 113929 297522 301442 245922 499417 81738 683983 53372 25497 499974 294429 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-RNO-159424.1 Conjugation of carboxylic acids 293779 353317 246263 688536 361637 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-RNO-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 500133 312937 58918 64044 313121 362491 300732 64314 311567 117514 282817 29665 60352 360557 290408 315435 287362 58923 116484 301252 60371 114495 301512 308267 304987 317546 24888 116725 311245 309295 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229662 HDL assembly 25081 83470 303796 24153 313210 293508 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism 681913 24651 25104 50522 289950 298942 81654 24439 81530 294320 89813 24533 288731 298982 24534 192255 83536 307270 315949 246311 361602 54705 81670 497900 302980 83529 290705 117098 369018 100912032 296849 311254 64156 364686 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231584 Regulation of HMOX1 expression and activity 24451 311545 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-RNO-202131.1 Metabolism of nitric oxide: NOS3 activation and regulation 64157 24600 311111 170520 292894 24185 24244 25751 25514 298184 29270 299331 80773 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-RNO-139853.1 Elevation of cytosolic Ca2+ levels 29665 60395 81739 29659 25262 114115 113995 25679 25505 81678 25041 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228378 Nucleotide biosynthesis 287420 65156 301005 288259 315150 295088 81643 24240 684425 117544 288051 362329 289276 140946 HDACS DEACETYLATE HISTONES%REACTOME%R-RNO-3214815.1 HDACs deacetylate histones 363481 502125 362981 24829 306945 24828 84578 313048 680498 290284 680615 365877 102554884 100362346 365755 302711 500569 310614 303175 361724 297893 290669 362834 64520 117535 64627 362825 497941 360531 83712 84481 293668 83618 314205 64646 NETRIN-1 SIGNALING%REACTOME%R-RNO-373752.1 Netrin-1 signaling 64465 25311 315615 60629 300955 54319 299737 83805 25614 25150 310192 363875 171119 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%10229454 Role of phospholipids in phagocytosis 295279 309014 289211 170911 25155 361527 25513 85243 360426 300678 170538 100360919 25738 29337 25097 29340 25096 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%10230764 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 25573 291772 313596 301442 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231570 RHOF GTPase cycle 83425 304282 503306 170824 685357 29448 78967 307016 290396 117955 287876 29579 81634 116685 64630 306183 25230 690130 310013 29528 362842 310074 25513 299012 246314 360840 317296 64160 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates 85482 289777 287634 192218 290805 293489 305000 308755 306734 300711 302982 360588 497856 302953 64012 499870 293678 497672 498265 293452 64557 102551085 303194 291787 498119 499966 689055 64046 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 97%10228724 Glucagon signaling in metabolic regulation 25521 25725 29699 24953 293508 HYDROLYSIS OF LPC%REACTOME%R-RNO-1483115.1 Hydrolysis of LPC 691905 361401 297694 311341 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-RNO-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins 365192 690559 246264 302783 100362170 116698 24829 306945 108348224 24828 117056 680498 685909 680615 365877 361487 303175 102546572 300266 689883 120095871 100909569 64627 690795 24522 102556967 PI3K AKT ACTIVATION%REACTOME%R-RNO-198203.1 PI3K AKT activation 25467 59109 29376 310738 170911 25513 85243 117273 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-RNO-173599.1 Formation of the active cofactor, UDP-glucuronate 83472 246232 G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events 24654 286924 83506 24611 81636 25238 25031 293508 302950 85240 64532 25521 25686 25289 25643 25725 29241 116590 84420 24244 170538 64508 81742 25050 81666 24681 29699 24680 81662 81664 60341 29691 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-RNO-69895.1 Transcriptional activation of cell cycle inhibitor p21 24842 685474 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%10230392 ATP sensitive Potassium channels 25559 83535 25472 25560 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-RNO-9619229.1 Activation of RAC1 downstream of NMDARs 171503 24244 83506 60341 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%10229478 Signalling to ERK5 ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins 286995 613220 613223 613224 286958 613225 24691 103690254 308873 290856 362347 25052 24932 498659 498658 683849 FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization 500052 292767 24936 366174 680264 689349 100910102 680912 290989 362623 499152 100362588 24163 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%10228776 PI3K AKT Signaling 294235 50557 361696 315093 79240 25267 24629 25660 81504 25408 25150 291171 500572 310306 79209 302415 313558 308875 84482 25266 116723 25443 296648 29348 24855 361388 170579 170633 309179 299147 312754 315189 310131 29183 24506 24505 140607 64022 24553 24446 314641 89812 25233 29613 287155 297893 83805 25433 25313 313050 365865 64156 311245 64030 315648 24329 363520 360471 50522 50689 363193 24673 192255 24672 309419 308051 117281 116590 100912032 25466 25467 117535 24890 29414 29149 361749 309361 29376 59325 58918 63879 81745 24185 25556 84477 25149 294515 60427 25622 301059 25513 85243 83571 296988 60664 170911 300177 366508 25489 100362346 310614 361724 290669 362834 64520 314850 294924 363875 246273 84489 361992 83504 66017 25444 29349 54250 25317 287772 292766 29369 291999 25022 29368 170700 116499 29669 29668 60662 60464 170583 81737 29425 289625 100360846 25114 25054 170582 25730 83712 24225 117263 25581 29666 81650 79114 303353 365388 29496 498596 432361 117262 85492 24827 298947 64545 497931 497932 287984 65138 313048 94198 29673 29671 29670 29677 29676 29675 307151 313038 309626 310258 303730 81827 294048 315136 24628 116549 83806 292887 311078 308869 310091 298514 501403 64226 295357 688041 297960 26954 117044 117043 56822 362045 56718 360776 59265 686412 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%10229102 NOD1 2 Signaling Pathway 500133 301512 312937 58918 308267 64044 313121 362491 317546 64314 311567 60352 116725 311245 309295 60371 114495 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296059.1 G protein gated Potassium channels 29718 294962 83579 81657 680149 25743 170847 58979 64199 114117 116649 24400 79218 50599 81667 83633 245986 116560 29713 60449 29712 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%10230822 Depolymerization of the Nuclear Lamina 25203 316737 54237 25023 287447 25437 24680 116685 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-6807062.1 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 293688 78968 300095 298298 29540 309262 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%10230326 Activation of STAT3 by cadherin engagement 316639 50654 63879 83502 25125 25697 305679 50522 361866 301334 84353 363875 192255 60371 81679 304109 64465 311163 100912032 83805 84407 24498 81736 64156 313806 100361294 24514 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10231706 Complex III assembly 293448 691506 497902 291103 686506 360826 685322 366448 301011 26192 288740 300047 120097699 102550385 291671 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-RNO-73943.1 Reversal of alkylation damage by DNA dioxygenases 303193 291905 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190374.1 FGFR1c and Klotho ligand binding and activation 83504 170583 79114 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 97%10231520 EGR2 and SOX10-mediated initiation of Schwann cell myelination 308376 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-RNO-2046106.1 alpha-linolenic acid (ALA) metabolism 498728 84575 50681 171400 25541 25288 501072 83512 79244 363516 309449 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-RNO-8847453.1 Synthesis of PIPs in the nucleus 140607 89812 364298 116723 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-RNO-212436.1 Generic Transcription Pathway 311796 305455 679203 25309 302415 313558 24370 60331 84482 26195 171335 654441 303393 26198 84683 25329 116723 94194 688386 681024 100188937 54322 364298 360229 24873 25282 29445 140607 24398 102555170 690675 252934 192268 288588 266713 291773 316123 317256 502227 690966 161452 361365 84389 170844 171152 309638 289561 292778 288651 288533 89812 373541 293345 294018 361580 116700 117526 294693 83503 117017 291703 498109 363633 287571 362485 83805 25747 303518 297867 296732 83833 361374 301020 361925 361825 64314 113898 29386 252860 102556092 192350 58839 102553962 259241 58850 58853 308986 102547287 65035 25578 686781 306571 58983 140942 108348224 498160 363292 83826 102555083 54278 365224 286979 100912096 292064 299810 282845 102548695 286996 293044 29338 102549410 290744 303226 306977 315210 102555289 24413 25622 100158223 685619 102546572 307839 102547413 100909569 299694 299210 306998 266734 102550851 314586 315427 287361 306966 24522 25735 78972 300197 116671 306816 365192 306817 81808 313596 25203 245980 54237 116698 102546648 298558 499874 499994 367034 266774 311567 500108 502894 114491 171355 59086 305837 683593 81812 683469 313219 360764 100360287 24377 680200 360896 293625 102555672 114592 287076 156726 314862 314621 84469 120095871 314993 313777 24484 287094 24577 310233 297065 498952 300320 293701 102556967 100362678 297066 312303 25672 498945 117254 291772 102553002 288003 25405 311546 116468 84385 314818 494339 25737 499900 81807 500855 288414 25533 114490 25697 309002 29175 282844 305000 313978 64525 297093 292804 685925 293849 308362 688328 309457 252917 100364132 691610 291164 170955 690895 679713 497923 361487 100362083 246334 29657 117274 60661 680717 102553866 100365779 362358 308561 308320 308326 365744 308322 246279 311613 300813 304758 100360427 114208 691422 24790 252924 499929 363445 120093538 25631 50659 500715 24666 100365683 680111 499068 362272 361178 29357 84396 690559 363481 246264 303539 100362170 687001 297453 689844 362981 56761 310405 363287 679028 24942 84580 303101 81785 497672 64557 363924 303194 315969 64046 308582 304514 79240 85482 192218 114212 290805 685055 310034 25573 308755 306734 301442 300711 297627 311860 295052 360588 497856 64012 294800 114494 498411 291787 100361529 140583 170824 140923 134478826 296648 24855 315189 310131 84353 50554 81516 690516 81920 313757 361831 25233 116484 25576 689820 56011 297893 25577 313017 309757 50662 361391 64156 288563 315648 24208 295384 362479 360471 50522 50689 24673 192255 497991 25664 114495 312451 100359816 24672 117281 100362634 102550344 116590 100912032 311575 117535 24890 29414 24705 685072 59102 309001 25682 58851 115771 64466 81745 24185 60421 84578 301164 60445 29753 25149 502988 362110 294515 25154 365755 302711 307511 25498 685474 140908 304798 83571 83574 85471 60349 310614 361724 290669 362834 301513 291841 287249 316034 29619 306492 363603 83722 312227 363221 58936 295707 29417 25242 365155 25243 60351 25591 289372 287772 292766 65248 287662 29669 29668 56010 29425 100360846 54281 83712 117263 25581 29666 81650 315606 303353 365388 290829 58919 302783 117262 85492 64562 24829 306945 287984 24828 65138 362093 313048 94198 293615 29673 304809 29671 29670 117056 29677 64033 680498 691504 29676 362675 29675 307151 685909 25193 313038 680615 304690 309626 363014 365877 25720 310258 81827 303730 25520 25172 315136 116549 83803 681178 24842 83806 313507 311078 500453 308869 361944 310091 25159 298514 501403 303175 64226 171046 295357 114483 373545 688041 297960 26954 117044 117043 64627 362045 690795 56718 304794 360776 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-112310.1 Neurotransmitter release cycle 116638 171163 24380 83589 83612 25531 84556 29647 81632 79213 29483 60377 29179 29642 84012 29482 25012 497009 25716 293645 50676 85426 29130 24398 64830 64832 25549 24379 79212 24904 29503 366432 79130 192268 140592 24468 66028 60422 24949 25558 25550 116470 24803 60442 CELL CYCLE%REACTOME DATABASE ID RELEASE 97%10228144 Cell Cycle 266713 84389 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 81515 83805 24514 362548 25578 361907 25203 316737 54237 25023 287447 25437 25515 114087 299204 113927 29648 116685 363174 64515 681185 297176 298594 114592 170845 305392 680089 308443 303037 362519 306464 362438 679342 296137 291441 24669 257649 257644 64041 287598 317252 289758 307805 311191 114764 500545 25448 305270 363028 89809 292058 286993 307639 102555739 315164 499914 114514 290842 298850 681050 83836 295661 363198 304951 288003 684439 311546 116468 289150 361416 304477 25737 288414 305000 85265 100360427 680111 361178 363481 287624 287873 299850 246294 81754 29489 25594 497672 64557 363924 303194 81655 315969 290997 64046 290631 316794 363059 85482 289777 311802 308768 192218 306102 114212 306599 290805 366403 406168 684111 298534 29564 361088 287927 65158 685055 308870 310034 81740 192228 25573 399489 308755 81758 297522 29479 361815 363055 306734 305467 301442 498266 294010 29214 500069 300711 692032 25164 307947 494444 290626 690043 305882 309098 297627 315423 171566 682033 367153 59294 315508 311860 300149 296099 295052 314787 361613 362960 360588 683722 497856 361916 292787 64012 361643 499870 360672 308064 294800 100362495 498265 362980 311573 293844 171121 313861 114494 310344 498411 311529 362203 308669 307169 287929 291787 246150 289468 305171 300963 60336 100361529 308663 252921 64462 680991 60347 361698 25255 140583 307347 362827 362704 365191 309179 299147 312754 29167 140734 361831 58945 282834 117103 315740 25233 303238 290232 297758 294025 500054 307798 307861 364996 25576 689820 56011 297893 25577 313017 361308 363720 64528 64156 309144 116725 304813 315648 116670 246772 64193 24708 294790 310806 292263 287432 297483 50522 50689 170944 499709 367645 691534 362288 363193 301965 252902 287273 24673 192255 24672 287280 290668 117281 361765 116590 171103 100912032 307585 311575 29414 85252 303024 360908 301323 299331 288532 316273 59102 295596 296178 29728 312046 313138 313479 306264 299112 364419 298098 292071 362385 312538 291927 307126 360621 304573 24185 362304 301430 85241 29753 301252 83572 499655 679886 366275 307511 171102 300126 25498 685474 308937 287101 304798 83571 360860 24680 290577 304218 65137 313304 680014 63996 684771 691979 305343 94266 58936 682908 64158 500377 117104 307833 246118 500363 300218 65201 498736 316531 307351 291081 84509 313478 679312 296554 29213 362700 500929 84490 287772 292766 94201 29669 29668 56010 58822 29425 100360846 83712 117263 25581 29666 81650 303353 365388 294429 287830 58919 291874 362281 302783 117262 113975 85492 292085 308839 295692 288272 24829 689399 117021 306945 689296 362335 287984 316602 24828 499873 65138 366016 58958 317425 313048 94198 29673 362557 65274 29671 113929 29670 29677 64033 245922 29676 81738 29675 685909 683983 25193 53372 680615 25497 365877 499974 81827 116549 24842 83806 311078 84027 303175 114483 64627 690795 24917 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%10228774 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 64026 100360940 63879 LAMININ INTERACTIONS%REACTOME%R-RNO-3000157.1 Laminin interactions 302248 309816 691517 81008 24511 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE 291534 289561 292778 288651 361580 294693 83503 117017 291703 313131 498109 363633 288588 293058 266713 316123 502227 690966 361365 84389 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 97%10231046 Protein repair 685059 361286 29447 25604 116484 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane 307811 287532 113918 314441 311168 29464 170566 29485 29484 282712 315439 252919 155205 192208 29642 664630 246235 298340 170573 305540 50676 50567 170567 50719 116726 83509 84551 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%10230598 STING mediated induction of host immune responses 314336 292892 299827 499069 498840 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins 287830 291874 362827 362281 113975 292085 295692 117021 362335 24874 366016 58958 300772 362557 25573 65274 113929 297522 291171 301442 245922 81738 83422 683983 53372 25497 499974 294429 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230868 Intracellular oxygen transport 170520 59108 85382 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10229688 ABC transporters in lipid homeostasis 286970 303639 287788 79248 299609 83519 25270 363516 25081 300664 84356 301482 155192 114628 302973 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-RNO-451308.1 Activation of Ca-permeable Kainate Receptor 24244 54257 29495 553106 58948 24407 24406 29559 298521 25252 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 97%10231300 MET receptor recycling 50866 25532 54245 24553 361388 24446 287942 81504 360658 79121 RSK ACTIVATION%REACTOME%R-RNO-444257.1 RSK activation 501560 117269 81771 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-RNO-1236978.1 Cross-presentation of soluble exogenous antigens (endosomes) 117262 295279 85492 287984 65138 94198 29673 29671 29670 498011 29677 29676 29675 81827 24968 24967 83806 311078 29614 287772 292766 29669 29668 29425 100360846 502852 117263 25581 29666 291983 303353 365388 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 117278 64191 298298 INSULIN RECEPTOR RECYCLING%REACTOME%R-RNO-77387.1 Insulin receptor recycling 362802 368044 296981 298451 299971 83615 170667 436582 297566 312488 117596 94170 116664 366545 360406 297932 298103 24697 25700 24506 24505 29757 289407 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%10229500 Regulation of localization of FOXO transcription factors 84482 29414 25578 56010 25233 24185 56011 302415 25577 313017 294515 313558 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-RNO-381119.1 Unfolded Protein Response (UPR) 54318 299027 498013 29702 314638 296302 304962 89842 303016 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-RNO-8964539.1 Glutamate and glutamine metabolism 361755 192268 25721 24957 24399 362428 24398 300035 364064 311844 64313 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-RNO-9909649.1 Regulation of PD-L1(CD274) transcription 302783 24829 306945 303175 24828 688041 362093 313048 64627 117056 690795 680498 304794 83712 685909 680615 315606 365877 290829 RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-RNO-73864.1 RNA Polymerase I Transcription 288651 361580 117526 294693 83503 297093 291703 498109 297893 100359714 83712 302783 24829 306945 24828 306274 313048 50689 117056 680498 685909 680615 365877 301246 100362346 304714 361784 360893 361420 310614 303175 361724 290669 362834 64520 313245 117535 680493 25574 362728 64627 83582 690450 690795 83581 266713 502227 690966 84389 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231388 RHOB GTPase cycle 317598 287537 503306 314212 307098 83620 120099896 311647 78967 297383 310635 310621 78966 290396 360942 140898 361921 29355 312108 117020 64665 360500 54308 83764 293024 361882 81679 64630 309696 64678 306400 312113 25537 29528 310074 25513 171296 299012 64373 307459 498130 29275 363031 306618 RNA POLYMERASE III TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10228536 RNA Polymerase III Transcription 246299 301246 685539 294687 114205 311487 310685 361102 117526 685465 690254 316810 83503 306012 304204 362537 306542 498109 362095 313914 171068 690966 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%10228758 Formation of apoptosome 50689 78963 295961 58918 100360940 63879 25309 116590 690675 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-RNO-5696394.1 DNA Damage Recognition in GG-NER 65137 316440 362258 360915 291737 361925 315523 296084 85423 50522 363273 287876 192255 302502 361381 261736 290027 363283 25591 100912032 64156 100362121 361181 117039 287367 298012 24919 293494 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 97%10229188 APC C:Cdc20 mediated degradation of Securin 117262 64193 85492 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 64515 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 361831 117263 25581 29666 303353 365388 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69473.1 G2 M DNA damage checkpoint 316794 25578 85482 288003 116468 192218 114212 290805 288414 287927 685055 29753 310034 305000 308755 361815 306734 300711 690043 297627 296099 295052 360588 497856 307511 64012 25576 56011 294800 25577 313017 308937 114494 56010 498411 308669 291787 116725 289468 100361529 140583 362827 25203 362704 54237 24829 306945 24842 303175 497672 64557 64627 363924 303194 315969 290997 59102 64046 290631 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-RNO-561048.1 Organic anion transport by SLC22 transporters 365398 89776 29509 83500 SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 97%10229992 Sodium Proton exchangers 24784 24783 311651 192215 24782 317170 363115 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-RNO-442742.1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 501560 117269 81771 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230384 PI3K events in ERBB4 signaling 25433 64022 498596 432361 59325 170911 25513 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%10230528 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 294235 25267 24629 29376 59325 24185 25660 81504 25408 25556 25150 84477 25149 308875 60427 25266 25622 301059 25513 85243 60664 116723 25443 170911 29348 361388 170579 300177 170633 309179 299147 366508 312754 29183 24506 24505 140607 314850 64022 24553 24446 314641 89812 29613 363875 84489 83504 66017 25444 29349 54250 25317 29369 25022 83805 29368 170700 116499 25433 60662 25313 365865 313050 60464 170583 81737 289625 25114 25054 170582 25730 24225 311245 64030 315648 79114 29496 498596 432361 363520 24329 24827 298947 64545 497931 497932 50689 363193 24673 294048 24672 24628 309419 117281 116590 25466 25467 24890 56822 29149 361749 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%10229676 Insulin processing 25506 252881 294698 305287 64632 60627 299903 171455 24506 116654 24505 50556 245709 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%10230942 VxPx cargo-targeting to cilium 25411 117103 314961 85258 24650 24717 679894 81830 29885 252881 309451 305287 64632 60627 171455 116654 50556 245709 79120 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%10231532 Recognition and association of DNA glycosylase with site containing an affected purine 307798 307861 302783 24829 306945 303175 24828 81528 64627 690795 685909 680615 290232 297758 365877 500054 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229682 Peptide hormone biosynthesis 29200 64549 25196 25447 83711 25204 25329 116700 24504 25653 NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-9974237.1 Negative Regulation of DNA Double Strand Break Response 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 302502 81827 83806 311078 287772 292766 100912032 497672 64557 29669 29668 29425 64156 100360846 117263 25581 29666 361181 303353 365388 RHOBTB3 ATPASE CYCLE%REACTOME%R-RNO-9706019.1 RHOBTB3 ATPase cycle 367915 65032 309922 24874 301555 56084 362566 84589 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-8864260.1 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 306817 291772 313596 64466 116700 25498 114490 314993 25573 304809 24890 114491 24577 301442 299810 25329 SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 97%10231366 Signaling by ROBO receptors 117273 DEPURINATION%REACTOME%R-RNO-73927.1 Depurination 307798 307861 302783 24829 306945 303175 24828 170841 81528 64627 690795 685909 680615 290232 297758 365877 500054 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME DATABASE ID RELEASE 97%10230610 Processing of antigen in germinal center B cells 24984 294273 290644 293502 29448 315740 50654 289168 287624 29564 25697 29175 299850 252902 353302 294010 29489 117550 84428 25423 299121 171549 29167 361308 85248 140734 84393 294269 316226 287531 24981 81655 24986 25424 58945 259221 171041 25425 314906 365542 684529 314473 361704 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%10229016 Mitochondrial Uncoupling 85333 25708 24860 54315 498226 85263 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%10229232 Chylomicron remodeling 140638 25081 24539 300027 25649 25728 292697 54225 25080 DIGESTION AND ABSORPTION%REACTOME%R-RNO-8963743.1 Digestion and absorption 65197 64055 25702 25552 25711 25680 25656 363465 497039 117554 289032 113901 50682 84028 432367 PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 97%10230900 Phase 2 - plateau phase 140725 50688 300992 116600 140728 63883 681190 24239 171138 367302 140727 140729 246150 84020 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-RNO-389661.1 Glyoxylate metabolism and glycine degradation 298942 685325 83784 25721 171133 25134 114027 306586 311446 299201 24792 360975 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing 290257 24493 29197 309452 81736 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle 116638 25531 84556 24398 64830 64832 29483 29642 84012 366432 192268 25012 29482 140592 66028 25716 293645 25558 25550 116470 24803 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 97%10231232 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 361907 81827 287280 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-RNO-418555.1 G alpha (s) signalling events 140928 25372 63885 25521 24511 81743 25725 25387 59075 50678 24627 308776 309962 25638 25388 85385 29699 25238 29516 29691 293508 RHO GTPASE EFFECTORS%REACTOME%R-RNO-195258.1 RHO GTPase Effectors 25578 363059 297518 81745 29564 290396 81504 303251 29753 60377 25614 297522 83572 288669 308875 29495 311860 25522 307511 24244 64373 170538 360840 24680 287746 83620 25023 300955 679934 25515 286928 292279 303811 302976 117542 29355 94266 309179 311793 360854 299147 312754 114243 83721 79249 84353 79129 29648 66021 294568 315348 363174 308666 64515 361029 681185 313024 297176 298594 114592 58823 170845 682937 360849 308443 303037 81824 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 307805 311191 308761 114764 58945 500545 25448 305270 363028 286993 102555739 315164 81531 114514 298850 681050 83836 295661 117538 314212 363198 304951 259242 79115 684439 289150 361416 304477 297383 94195 83502 367901 310621 65201 64303 100360623 29417 29431 363131 29432 117550 83724 363875 116547 24255 300030 293860 65052 300225 288057 25576 85428 500569 56011 25577 313017 117273 56010 171041 304813 315648 114004 298144 116670 294429 24208 287830 81732 302783 501099 292085 24829 306945 287624 24828 29433 50689 117056 252902 363193 680498 29489 81738 24673 362548 685909 683983 680615 287876 25594 289820 365877 24672 64465 25537 117281 171549 81822 303175 54227 116590 64627 316226 690795 85252 81655 314906 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%10230584 Crosslinking of collagen fibrils 678743 83470 365460 24914 290350 309380 29569 554172 315714 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%10229780 Nuclear Receptor transcription pathway 25682 58851 81808 79240 65035 245980 84385 83826 54278 25149 24873 252917 81812 497991 25664 60351 25154 360896 117274 24413 365744 299210 83574 24890 25747 252924 24705 60349 685072 50659 58839 293701 100365683 25735 259241 58850 24208 58853 25672 METABOLISM%REACTOME DATABASE ID RELEASE 97%10228234 Metabolism 299857 25096 307428 298504 293173 500132 306460 246074 171410 171402 171400 170465 362058 363159 25329 170570 116723 295674 54398 364134 100363074 500292 690610 29470 295458 294255 304474 191576 499570 64677 404280 364298 287467 25511 25756 25757 288322 287115 367112 24873 359725 25097 361802 407765 287366 266604 114561 116740 140544 287533 81925 117543 246153 80841 301131 140607 81919 301024 307234 58924 290843 24950 360753 314553 360521 301120 192260 25559 362702 290223 315973 64828 83588 683713 50555 302425 289125 293620 305935 300129 25598 364901 291699 63888 361401 362972 24230 289021 300108 361895 25736 498728 84575 361659 26759 681694 24450 89812 287380 25557 361676 116700 361433 65984 117243 691478 300783 619561 291541 25413 25524 100911581 361694 25083 680115 84013 79131 25062 361467 83512 363521 117182 246237 25653 296851 286936 314800 83626 83505 680971 295417 678749 296623 308584 367786 25288 25045 60418 310663 60666 29411 309449 305291 365984 365865 291211 170919 293688 29510 25675 311617 29637 282584 619549 362249 24159 81726 298298 29726 81727 94340 29540 305150 29230 25363 308100 311821 309262 679520 310645 64822 117278 306490 114100 310508 83791 305166 81681 64191 78968 300095 140910 29580 89784 363103 266607 25051 24175 24953 316737 24377 498331 259221 114508 25741 24651 362282 25697 24334 25104 316265 315722 292804 25060 25738 292138 24189 29337 296973 289608 54283 25634 25438 58978 140860 685076 266682 24385 66020 84024 312086 303565 252931 100364027 24638 24192 24959 361730 684314 294321 60416 24188 24788 498731 25659 24191 24849 25059 24640 24642 24644 25658 29573 117276 24362 65152 290985 63865 25748 65155 298947 25374 289219 497931 304024 691853 497932 309391 309070 361338 24439 294320 24533 298982 24534 83536 307270 315949 361602 497900 302980 290705 369018 64157 25615 311111 170520 287420 65156 301005 288259 315150 295088 81643 24240 684425 117544 288051 362329 289276 140946 25573 499417 362827 85333 311422 171047 361068 100363253 24239 361274 287406 305149 313574 117260 298881 497811 54233 83842 54232 83522 298657 404783 499125 300993 314140 367166 100301568 24434 81651 266805 501157 114122 114597 50568 499566 25181 157074 363513 298003 366064 298690 291819 362706 302669 100360180 24368 25694 312670 114101 311580 64045 315939 290741 114096 171078 294521 313560 309004 298410 79250 313706 102238592 690987 58964 361378 362720 362474 24183 116484 246253 24184 50655 310864 311833 299976 64152 296564 685579 29223 171408 83782 170587 191575 399684 365985 294103 29261 363061 295443 619580 497778 29562 24848 690945 298596 25120 24311 287479 317675 304885 246281 361726 287069 282821 288161 310378 64524 84597 301624 289217 313843 306866 94173 24689 362323 289036 364686 64156 316067 25095 290277 362015 362383 290029 309513 192357 246136 79127 83688 24165 117533 24465 25028 297389 25368 292072 300447 24470 682974 29632 299270 50522 25146 25116 360348 25117 289014 192255 362039 691905 29354 309419 24913 29692 308309 295631 298579 29526 29359 297694 100912032 296849 311254 299331 291283 307092 25682 307096 363026 308190 24886 25527 25526 84578 59103 29224 58962 64199 24654 289950 298942 81654 79218 24172 361266 81530 89813 245986 301252 364773 60449 25031 498790 293508 362809 85240 294962 117098 64532 25521 25686 498789 25289 365755 302711 25725 316039 83579 361686 85311 680149 171516 58979 24244 114117 24400 312495 81666 298184 81667 29699 140868 191574 24680 81662 81664 25270 363516 294449 688293 293451 64537 307170 295430 360630 65183 84406 364476 108349781 303218 302489 292155 29633 363618 24307 114002 29142 290623 368128 266674 684979 24894 299907 83529 24299 502969 298423 24895 286904 313375 24306 171522 299566 503122 54246 171178 50549 295934 300757 291015 301525 303923 316583 305571 84400 362275 84468 363040 64442 64445 293667 293154 367145 307859 294673 314771 316033 81506 292073 64507 313536 500961 494342 362924 81682 58968 65196 25429 266761 301517 25426 25428 300027 79122 25427 29189 313786 83724 25242 362782 25243 60351 29680 498999 361663 310856 287772 292766 29669 29668 29425 100360846 117263 317296 25581 29666 81650 25393 303353 365388 117262 85492 25406 64562 287984 65138 100169747 64304 94198 29673 29139 29671 29670 29677 29676 29675 302899 290638 24813 64037 63864 81827 29700 311374 58835 116549 117100 83806 24250 311078 50676 309732 29383 306586 81718 373545 29711 114613 367181 83586 24264 24265 50567 308652 361755 64040 81508 291450 100360621 293871 290484 170907 361884 50690 309150 363024 363285 294972 25699 50557 310152 685325 85309 311358 25331 306574 65151 246307 29221 117024 311446 79213 303272 64192 65162 290551 66029 288912 81522 29475 81640 25430 114089 84596 29592 288740 298607 25309 24314 292845 25085 298748 24792 293655 29443 81728 291671 89833 81670 293453 499330 298147 497840 681319 691506 316062 293130 266807 25668 497902 79462 296167 29215 299310 306262 26195 170898 361300 79107 499529 50671 26194 81660 171053 367323 171335 362428 686506 85496 361215 364064 499328 654441 26199 64392 360816 303393 64313 293504 298227 300886 361385 26198 64001 294421 297508 59085 681896 84683 79251 300328 25502 353255 497863 681418 64845 29301 301011 313241 308129 26193 313520 308800 26192 85254 29319 171133 289522 309465 361751 301458 364975 311536 64564 300047 296658 25035 50719 64201 64203 361472 64206 301416 687008 317444 100125370 299201 24661 361836 297821 56823 102550385 289095 170551 26203 691966 288240 24513 26202 25044 94194 301221 171151 64533 300726 287711 192172 688386 681024 681913 29723 24312 306840 362322 294088 25618 100188937 298934 26201 362134 292710 362440 299699 298490 304429 54322 29416 83578 360826 360229 25611 291939 366448 25612 360639 315439 303922 363069 680308 289218 29531 360511 365972 293114 304735 303333 140547 362657 303306 301427 751787 25488 293779 296925 293991 64300 25721 315085 100365773 81805 81829 295229 25732 313450 361272 298653 312381 64539 25282 363118 114027 305248 361520 689588 50622 63938 309111 120097699 54349 311844 29445 311849 60581 360975 50621 362495 24551 365699 305177 290947 362942 296190 362810 300723 289727 293448 116682 678759 294973 83784 25274 291103 100912357 301384 315167 24957 24401 24399 295143 29603 24398 362588 296086 81708 685999 361894 685322 170943 25244 102555170 300384 690675 24609 690354 25014 301123 25256 56769 252934 59113 24962 192268 29611 114123 246266 25134 300035 304208 353229 499174 366065 360618 500624 312382 58970 24565 296188 80773 361213 314438 100270678 310667 500651 170897 366697 366984 307855 310849 500052 360833 25287 308589 113965 171155 170670 113902 25514 25747 296732 24782 288731 246311 54705 25523 24600 25262 366196 54259 24267 65038 25216 29539 25297 300992 116600 25513 85243 60664 25398 81747 170911 116482 364629 116720 291585 289801 304944 295620 315219 311864 362638 291824 366508 289456 116463 691018 25322 296972 79243 85260 64467 309390 316077 613267 314312 64310 291577 291770 297554 500257 304322 302302 286974 365583 25751 297865 314694 316533 361450 361632 25679 81678 26197 26196 363131 116721 361992 25303 65052 83535 25081 140668 25571 245958 140608 300677 171082 94271 245965 171069 29754 362749 641434 690441 171375 192241 29725 65262 362360 171374 298369 502348 24777 296461 79111 25440 308518 311129 25541 246211 291075 303497 303879 503049 170698 83569 79244 85255 24186 50559 309527 297029 300790 65192 192242 50681 84114 84470 140940 24479 114209 113956 79238 85239 84029 64461 498332 314304 501072 171142 303577 89842 306808 50560 308445 59268 171458 305419 288762 497197 114554 24655 116699 307842 282636 309855 688862 316457 308451 171088 80849 500709 310155 94267 81677 294292 140693 29688 365382 290651 316376 114633 54260 297522 29216 83523 252899 299825 94197 292894 25708 24860 54315 85263 295347 300147 114024 113976 678739 29353 361377 54225 140671 367562 64035 81675 307091 362029 314641 360426 312689 64633 305482 29244 29498 171128 29270 312634 79223 362732 85238 296130 681211 29653 84497 25532 252900 363494 114104 303729 25227 24158 498226 311013 84018 29624 316642 83537 303631 117185 289687 94338 315222 24800 365619 310326 684536 362409 307404 84431 497991 294324 308453 365592 498909 296128 366013 304542 299195 360887 25249 313521 29309 116593 81656 287368 65135 312373 288025 289733 24185 293711 291394 314075 63867 296048 58953 311341 246232 362434 83472 313997 156275 24421 498741 24423 24422 24424 94199 298079 24426 360268 361510 310201 25750 246245 310848 361637 78959 140925 290401 24912 297433 81869 494499 312952 25283 116632 25551 116631 29487 300981 300983 266685 24778 501907 291984 286954 362196 24539 288617 25458 25649 501110 25728 113992 690050 64352 292697 64473 293653 408206 116568 295037 114700 25080 25260 683630 57300 287454 171451 29527 29328 100145871 79242 24902 81639 303953 29277 288517 114097 25279 25086 296259 299732 25315 291084 24296 171445 24297 29473 499689 26760 65030 25290 116684 688536 83783 498940 499353 290681 286989 503103 360994 29566 171072 353317 64305 29739 171347 246263 25375 304078 310903 171341 287424 292915 287425 24404 84493 691984 171517 24710 25703 24856 25702 25680 192259 116673 24771 299858 362558 64047 317322 25236 315644 58920 314941 25592 25056 55939 84509 54231 29242 310218 310773 29367 89841 59326 360843 29194 24861 494500 24360 116599 24451 79239 292737 499210 286896 313339 301118 246115 309147 294429 287830 291874 362281 113975 292085 360670 29254 295692 117267 117021 362335 316559 305889 366016 680668 303676 58958 289175 293615 361596 362557 65274 113929 117099 366463 690163 245922 81738 683983 53372 25497 499974 312947 314459 80848 24917 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 97%10230298 Serine metabolism 303306 25044 58835 311358 304429 170907 360816 294421 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 97%10229568 G-protein beta:gamma signalling 294962 64465 298947 497931 25233 497932 83579 363509 81745 24185 680149 117273 58979 64199 114117 29414 24400 79218 29431 81667 245986 60449 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-RNO-113501.1 Inhibition of replication initiation of damaged DNA by RB1 E2F1 682033 24672 24708 24673 117281 301323 315648 85241 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%10231684 Regulation of endogenous retroelements 365192 690559 246264 302783 100362170 116698 24829 306945 108348224 24828 117056 680498 685909 680615 365877 361487 303175 102546572 300266 689883 120095871 100909569 290270 680155 366975 64627 690795 24522 102556967 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 117262 85492 114212 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 300711 192255 81827 24842 83806 311078 287772 292766 100912032 311575 29669 304798 29668 360860 29425 64156 100360846 117263 25581 29666 303353 365388 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis 81645 59325 360915 60568 311854 60566 81504 303251 60564 24180 29216 25388 500985 360202 25238 312689 24255 363466 64558 56084 25490 114590 25372 300438 85256 85491 140670 298598 25433 300678 25313 290639 292944 64156 25710 84357 24932 24221 287367 266606 314349 24825 24329 24827 81922 313474 117106 50522 363273 498798 29183 25716 363266 192255 116561 24805 261736 81921 79128 24807 116563 363283 64678 116743 29528 89816 311030 361244 83730 361120 29491 25387 100912032 192152 65046 64022 312694 117277 313934 54225 83800 60422 117039 65178 54241 317396 25151 25108 24803 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-RNO-9958863.1 SLC-mediated transport of amino acids 307811 287532 113918 314441 311168 29464 170566 29485 29484 282712 29483 315439 252919 155205 192208 29642 664630 246235 84012 298340 29482 170573 305540 50676 50567 366432 170567 50719 116726 83509 25550 84551 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-629594.1 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 25590 25103 81721 54239 170945 171131 65024 25302 79557 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases 24217 365266 303056 306600 25390 171496 360932 303856 116601 290673 25400 362645 25391 64672 24211 29693 24212 24213 29600 63847 63848 29599 29598 58971 64190 116831 29639 29132 24245 24246 171140 24941 24244 288026 361929 291411 291555 25650 311396 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-RNO-6804756.1 Regulation of TP53 Activity through Phosphorylation 170844 171152 309638 58936 85482 288003 311546 116468 192218 288533 114212 373541 293345 290805 294018 117526 288414 685055 310034 305000 308755 287571 306734 300711 297627 295052 360588 497856 685619 64012 294800 299694 65248 140908 304798 114494 498411 64156 291787 81650 100361529 362272 116671 140583 64562 50522 81785 192255 25520 116549 83803 24842 114592 314862 314621 373545 100912032 497672 64557 313777 363924 303194 315969 291773 317256 59102 64046 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-RNO-77288.1 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 24158 117543 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%10231054 Homologous DNA Pairing and Strand Exchange 140583 85482 192218 360588 497856 290805 64012 499870 497672 293452 64557 305000 308755 102551085 306734 303194 291787 300711 499966 689055 64046 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%10230886 CHD chromatin remodelers 297093 25573 301442 81781 292019 297893 291295 100359714 83712 50659 291794 302783 24829 312974 306945 84401 311607 687711 303511 24828 307362 362093 305501 313048 680891 293038 83726 300389 360609 308738 291940 363064 245957 64622 293184 117056 100362099 113984 406195 361531 681031 680498 81785 303060 100361269 103690021 360804 84353 685909 192246 680615 65027 365877 303607 171365 313583 300837 680737 305479 100362346 290614 310614 303175 361724 290669 362834 64520 287768 117535 299620 64627 295270 690795 84486 304832 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-RNO-8852276.1 The role of GTSE1 in G2 M progression after G2 checkpoint 25203 117262 85492 54237 25515 287984 406168 65138 94198 29673 50522 29671 29670 29677 29676 29675 301252 192255 81827 24842 83806 311078 287772 292766 300126 100912032 29669 29668 29425 64156 100360846 114764 117263 25581 29666 299331 303353 365388 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 97%10230894 Mitochondrial translation termination 303746 295238 293054 309176 298517 26200 293754 297799 361883 311903 363023 301552 299628 497876 686234 26197 26196 683519 288916 294230 309140 100363539 360594 500199 299938 292758 287962 295224 296551 171061 292244 363646 26195 689432 26194 361473 361005 310653 362216 26199 297601 56281 309440 287656 26198 297459 301250 301371 364656 287302 26193 293666 26192 296134 303685 64360 113958 294767 684304 680747 301352 290850 26203 297372 26202 301240 498406 26201 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%10231650 Regulation of MITF-M-dependent genes involved in apoptosis 690660 25094 297893 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 97%10231766 tRNA modification in the nucleus and cytosol 361201 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-RNO-5389840.1 Mitochondrial translation elongation 303746 295238 293054 309176 298517 293754 297799 361883 363023 301552 299628 497876 683519 288916 294230 309140 100363539 360594 500199 299938 292758 287962 295224 296551 171061 292244 363646 689432 361005 310653 362216 297601 56281 309440 287656 297459 301250 301371 364656 287302 293666 114017 296134 303685 64360 113958 294767 684304 680747 301352 290850 297372 301240 498406 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%10229084 RIP-mediated NFkB activation via ZBP1 25493 84351 304859 309361 301059 287707 309452 309295 81736 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling 313050 116562 85385 25704 25155 24918 25746 50646 25326 25126 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH 316235 288003 116468 289508 25737 288414 100912032 50522 64156 116643 292101 89809 84478 59102 192255 140639 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-RNO-8937144.1 Aryl hydrocarbon receptor signalling 362809 25242 301252 25243 498999 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-RNO-450302.1 activated TAK1 mediates p38 MAPK activation 500133 363520 362418 308267 313121 362491 317546 289014 116725 311245 315994 309295 114495 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%10230290 N-Glycan antennae elongation 313536 494342 65196 291325 25197 303100 303923 117523 65271 367252 362275 25547 363040 299756 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%10228490 Sensing of DNA Double Strand Breaks 85482 192218 300711 64012 64046 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-RNO-2142688.1 Synthesis of 5-eicosatetraenoic acids 114097 84024 29624 312086 25290 296851 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-RNO-77346.1 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 140547 29470 24158 113965 171155 170670 INTERLEUKIN-38 SIGNALING%REACTOME%R-RNO-9007892.1 Interleukin-38 signaling 116554 171106 317553 362077 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-RNO-442729.1 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 24244 83506 25050 60341 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975163.1 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 60350 362418 29260 308267 313121 100912032 317546 364867 448830 50522 64156 311245 192255 363328 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296041.1 Activation of G protein gated Potassium channels 29718 294962 83579 81657 680149 25743 170847 58979 64199 114117 116649 24400 79218 50599 81667 83633 245986 116560 29713 60449 29712 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%10231228 AURKA Activation by TPX2 83836 64158 311802 311546 366403 316531 29753 81740 192228 29479 296554 363055 29213 305467 294010 29214 500069 83572 290626 305882 315423 367153 314787 683722 360672 308064 100362495 311573 293844 310344 56010 311529 58822 246150 300963 252921 64462 60347 307347 54237 25515 299850 29489 117281 29167 311191 114764 58945 299331 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-RNO-8849469.1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 50522 366275 64156 500985 24185 192255 312477 361617 100912032 REGULATION OF TP53 ACTIVITY%REACTOME%R-RNO-5633007.1 Regulation of TP53 Activity 85482 686781 306571 115771 192218 114212 290805 81745 24185 363292 685055 310034 308755 306734 300711 292064 282845 297627 290744 315210 295052 360588 497856 685619 64012 294800 685474 299694 140908 304798 114494 498411 291787 100361529 116723 116671 140583 54237 296648 364298 171355 315189 310131 305837 683593 140607 114592 314862 310614 314621 361724 290669 362834 313777 291773 317256 170844 171152 309638 58936 288003 25405 311546 116468 288533 89812 373541 293345 25233 294018 117526 288414 282844 305000 287571 679713 246334 289372 689820 297893 65248 311613 64156 83712 315648 81650 362272 361374 64562 360471 313048 50522 81785 362675 24673 192255 114495 25520 24672 116549 83803 24842 117281 64226 373545 100912032 497672 311575 64557 117535 29414 363924 56718 303194 315969 59102 64046 SIGNALING BY ACTIVIN%REACTOME%R-RNO-1502540.1 Signaling by Activin 29200 25196 29263 50554 116590 24504 50689 24373 25631 29381 245921 25366 29357 29610 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-RNO-170822.1 Regulation of Glucokinase by Glucokinase Regulatory Protein 287830 291874 362281 113975 292085 295692 117021 362335 25658 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 24385 25497 294429 499974 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-RNO-68881.1 Mitotic Metaphase Anaphase Transition 292263 25515 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%10230604 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 498728 84575 50681 171400 25541 25288 501072 83512 79244 363516 309449 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230198 HS-GAG biosynthesis 684979 299907 691984 25216 171517 25615 116673 24771 294449 317322 293451 25236 295430 58920 25592 84406 364476 108349781 303218 302489 292155 29633 363618 114002 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade 24232 155012 113936 113959 24233 298566 406161 24854 29687 84007 365466 362634 295703 100360919 54243 79126 445269 117512 29333 312705 192262 289395 303861 299606 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%10230508 Sulfide oxidation to sulfate 691966 81805 292710 170943 83586 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%10228808 Platelet homeostasis 81739 29659 116601 79113 114115 113995 25679 25505 25391 81678 29693 25041 29600 29665 29599 29598 60395 313611 25622 24244 292661 315648 116689 29691 29583 309179 29715 299147 363193 312754 24673 140447 140448 140928 63885 25523 24672 24599 24598 24600 81743 171115 25262 117281 54286 191569 308899 362558 54225 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-RNO-9701898.1 STAT3 nuclear events downstream of ALK signaling 25125 297893 84578 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229768 NCAM1 interactions 116696 117523 290905 306628 24586 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%10230988 Phospholipase C-mediated cascade; FGFR3 66017 25444 29349 54250 25317 29369 29368 116499 60662 60464 170583 25738 84489 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-RNO-5693607.1 Processing of DNA double-strand break ends 316794 171366 85482 288003 116468 192218 290805 298534 288414 287927 685055 310034 305000 25573 308755 361815 306734 499417 300711 299638 690043 297627 296099 295052 360588 497856 64012 294800 114494 498411 308669 291787 116725 289468 100361529 297486 140583 362827 362704 24829 306945 303175 497672 64557 64627 83508 363924 303194 315969 290997 59102 64046 290631 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-RNO-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 305000 59294 81685 289758 81709 25737 59102 361698 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-RNO-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) 83614 690244 299112 171525 298098 288003 288651 362385 360915 116468 304573 25737 361580 288414 287927 294693 25573 291703 301442 499417 302502 290027 59294 25591 300813 64156 116725 361181 287367 298012 293494 361698 65137 316440 362258 291737 361925 315523 296084 85423 50522 300772 363273 287876 192255 313098 361381 261736 363283 100912032 304719 289758 266713 100362121 310707 502227 89809 117039 59102 24919 84389 RAC3 GTPASE CYCLE%REACTOME%R-RNO-9013423.1 RAC3 GTPase cycle 306152 361940 29448 78967 307035 290396 307562 688319 312108 362456 29431 29432 305234 292756 308509 315121 29579 64630 309696 63994 24511 362842 25513 307459 100363276 360840 305367 317598 295635 287537 304282 29146 83709 64351 679934 25437 311647 300186 286928 304546 292279 302976 117542 304530 311793 310192 114243 79249 79129 66021 294568 315348 304109 308666 64465 64678 306400 313024 366492 116666 29528 308869 58823 310074 299012 310519 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 97%10228582 Transport of the SLBP Dependant Mature mRNA 287830 291874 362281 689116 113975 681062 298075 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 59087 499974 690585 117045 294429 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%10230792 CASP8 activity is inhibited 266610 306886 64044 246097 117279 25385 246756 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-RNO-500657.1 Presynaptic function of Kainate receptors 298521 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-RNO-2142816.1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 266674 25426 29277 286904 24296 503122 24297 310848 290623 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 97%10228158 Polymerase switching 59294 288003 289758 116468 301323 25737 89809 288414 85241 361698 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-RNO-446652.1 Interleukin-1 family signaling 290257 314870 317553 117022 362077 25556 361677 296541 84388 373540 299827 301059 287772 292766 311783 29669 29668 29425 64156 100360846 25742 116725 117263 25581 311245 29666 309452 303353 309295 365388 310877 117262 363520 85492 291921 29197 64044 287984 313121 300177 65138 287707 25125 94198 29673 50522 499744 29671 84351 29670 171106 29677 305549 60582 29676 301365 29675 315599 500900 192255 309157 114495 81827 116596 116554 287280 83806 362418 311078 308267 361765 291861 113894 100912032 25466 317546 81736 25493 312688 24493 54226 361749 309361 303024 303604 ALANINE METABOLISM%REACTOME%R-RNO-8964540.1 Alanine metabolism 81670 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing 300208 689116 298075 289561 501926 292778 687711 691538 680891 83503 117017 363082 498109 363633 100362099 494445 681031 360803 302670 303607 171365 292019 680737 362687 295270 288588 366276 316123 291060 689890 500538 362990 690966 84486 361365 287530 291794 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 97%10228590 Formation of the Editosome 301226 25383 498251 170912 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 97%10230908 Physiological factors 289596 24603 24602 24590 114593 113902 116564 REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA 79212 171163 50676 79213 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 97%10228992 AMPK inhibits chREBP transcriptional activation activity 289036 64562 246253 373545 312670 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 97%10229170 Autodegradation of Cdh1 by Cdh1:APC C 117262 85492 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 361831 117263 25581 29666 303353 365388 EICOSANOIDS%REACTOME DATABASE ID RELEASE 97%10228550 Eicosanoids 266674 298423 286904 24306 299566 24886 503122 25527 24307 50549 290623 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%10230968 Nuclear events mediated by NFE2L2 117254 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 83619 287280 83806 311078 84027 361765 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 97%10230454 Acyl chain remodelling of PG 362039 691905 29354 29692 366196 295631 298579 289733 29526 29359 296048 311341 361467 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%10229534 Apoptotic cleavage of cellular proteins 292994 64044 64159 83502 298534 307562 25614 24205 25402 306871 291755 84353 361092 83497 116685 60371 24170 304822 64026 317589 296654 81818 305884 316164 367786 170538 25318 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-RNO-3065678.1 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 25573 308384 304132 301442 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229964 Adherens junctions interactions 83427 63879 83501 25066 25150 292064 25507 313806 100361294 362850 316639 313474 25125 301334 84353 81679 311163 300289 25751 314641 50654 83502 25697 266758 363875 60371 293142 84430 688673 25705 81717 500569 689820 287772 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 29425 64156 100360846 54281 24790 83712 117263 25581 29666 81650 24514 303353 365388 302783 117262 85492 192275 24829 306945 287984 24828 65138 313048 94198 29673 50522 305679 100188932 29671 361866 29670 117056 29677 680498 29676 29675 685909 680615 192255 365877 686092 308417 81827 304109 64465 116549 26955 498515 83806 310174 311078 192248 117048 313648 192183 303175 360687 498281 688041 301887 29181 100912032 84407 497229 24498 81736 303068 300445 361432 363058 29144 25409 64701 64627 29606 500870 78947 690795 29163 29162 293721 360882 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 97%10231022 Metallothioneins bind metals 689415 117038 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-RNO-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 362600 290027 59294 84490 299112 298098 25591 288003 79116 362385 29240 116468 83507 25737 304573 288414 289758 89809 59102 361698 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-RNO-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 298942 29611 29711 25244 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%10228790 Coagulation pathway 24617 308637 25216 360918 306761 29302 25087 29436 171154 306608 499099 260320 691984 302470 171517 25615 362248 24366 24367 685269 116673 24771 60327 315272 24946 79224 29366 691992 25268 502858 295703 317322 25259 65051 304917 116727 25236 29243 289055 314615 58920 54226 25592 83580 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-RNO-9758881.1 Uptake of dietary cobalamins into enterocytes 314459 80848 29319 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-RNO-199977.1 ER to Golgi Anterograde Transport 362237 362599 306264 503165 289257 305614 64159 79117 29564 314251 252889 29631 93646 314030 297522 308458 295461 252929 294010 292074 84428 289994 290994 54400 171121 24648 64462 89868 290659 64351 361705 29183 301012 24506 24505 287427 683007 64310 114023 302470 304978 116666 117513 100360302 140673 29167 140734 58817 58945 501550 60355 192243 690252 367073 100912115 299075 60384 300674 291990 25423 299121 50592 309010 246310 64528 171049 309144 84599 64154 287275 287276 362162 25407 361073 94189 54350 315059 680465 361207 24827 65134 297428 361577 304290 58842 363136 293456 299850 309451 252902 81754 29489 300888 246117 79120 252853 310411 140940 309678 65165 300743 56042 685144 81655 690961 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-RNO-193634.1 Axonal growth inhibition (RHOA activation) 317598 24596 29409 360678 83765 450224 117273 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-RNO-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors 503164 117254 24791 24440 360504 362862 94195 64202 299858 25081 360922 100360919 25728 25073 54225 315111 24464 25377 312701 24186 58917 BIOSYNTHESIS OF PROTECTINS%REACTOME DATABASE ID RELEASE 97%10231436 Biosynthesis of protectins 81639 299732 24296 24297 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%10230854 Selective autophagy 192647 29564 641452 50522 246294 56816 64862 252902 29489 300711 288731 362245 361321 192255 363442 24255 365601 363836 83529 116549 83532 299827 83531 299514 266601 360827 298575 685620 312703 363254 300075 308416 304017 113894 100912032 83805 117287 140734 81920 64156 303554 81655 304579 58945 116725 81650 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%10230748 SUMOylation of transcription cofactors 83614 310258 315133 362827 690244 303730 290744 310375 313128 116698 501403 25498 117287 287662 29382 300772 304157 25573 301442 499417 83422 307151 313038 309626 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-RNO-399710.1 Activation of AMPA receptors 50592 29629 29628 29627 NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism 499330 81506 316062 25668 367323 293504 297508 353255 313241 315085 295229 298653 361751 363118 100125370 289095 365699 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 97%10228422 RNA Polymerase II Pre-transcription Events 170844 83830 689116 171152 309638 311796 298075 289561 305455 292778 679203 288651 288533 373541 293345 294018 361580 81807 303918 117526 294693 83503 117017 64525 291703 498109 363633 287571 303281 362110 303132 114510 306261 304758 500715 266787 362479 363064 293184 361531 81785 301119 683469 291705 300837 288588 266713 291773 316123 317256 502227 83828 690966 361365 81673 304832 84389 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-RNO-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) 84509 301024 78968 300095 24917 89842 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 689116 298075 501582 24420 100125373 287596 691397 287522 365215 171350 361271 360855 684558 307503 259170 287113 291434 81729 25347 29304 25348 28298 65136 27139 298385 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 295284 94266 140654 140655 313449 690303 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 81773 81774 245981 497860 81770 361109 117104 691531 64640 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 29285 124323 29284 29283 29282 296709 64302 64306 100360439 64307 64156 122772 134486107 50522 24672 117281 688288 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-RNO-174113.1 SCF-beta-TrCP mediated degradation of Emi1 117262 85492 292263 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 64515 287280 83806 311078 361765 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins 25507 310738 54281 116548 HDL REMODELING%REACTOME%R-RNO-8964058.1 HDL remodeling 25081 291437 25728 292697 24530 24186 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230826 SUMOylation of chromatin organization proteins 287830 291874 690244 362281 113975 292085 295692 117021 362335 363287 366016 58958 501145 300772 362557 25573 65274 113929 297522 301442 245922 499417 81738 83422 307151 683983 313038 53372 25497 309626 499974 310258 303730 316164 501403 297893 688041 287662 64627 300320 294429 UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 97%10230208 Ub-specific processing proteases 688466 50557 115771 312937 298534 288306 361190 100361658 313427 310960 308896 302488 290652 408217 310306 363164 361495 304150 302415 307905 499801 362636 56084 314453 297593 171329 311856 293705 288482 295052 363084 298576 315911 360763 315639 171102 304798 114494 85471 683630 65137 114558 79257 83529 29591 83532 64515 83531 50554 266601 311030 81516 304017 25387 25671 24577 100362121 296121 171152 293345 29560 306886 25388 25700 24255 60371 29240 287772 292766 29669 29668 29425 64156 100360846 304579 309153 117263 363445 25581 25631 311245 29666 303353 309295 365388 64646 29357 24208 502125 303539 117262 85492 294790 287984 313121 360471 24828 140593 65138 94198 29673 50522 29671 29670 29677 29676 684097 29675 680615 84478 192255 365877 29134 81827 24842 83806 311078 308051 100912032 360990 25493 312688 361749 362414 290864 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-RNO-5423646.1 Aflatoxin activation and detoxification 24894 171341 24299 24895 171445 24297 300981 26760 291984 156275 94199 29566 293653 408206 116568 266682 295037 252931 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway 24377 29562 24689 690945 287479 362383 362706 100360180 83688 314140 64524 501157 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229020 TRIF (TICAM1)-mediated TLR4 signaling 641452 246240 266610 306886 60371 299827 25622 287545 252961 362788 292892 64156 25742 81647 116725 314322 311245 315648 363328 309452 309295 81771 310877 117269 500133 60350 363520 29260 293624 291921 64044 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 246294 363193 24673 315599 500900 315994 192255 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 81920 448830 25493 312688 116663 54226 309361 60587 361831 303024 DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions 24223 24605 292844 293621 170911 25155 367901 81504 24525 25528 295378 25150 81511 313845 25738 29337 366962 363875 24934 361537 29684 679787 25513 25110 85243 498888 313050 301229 85385 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-RNO-109606.1 Intrinsic Pathway for Apoptosis 25578 64639 78963 295961 58918 100360940 64044 63879 29753 50689 171528 25402 259274 64547 116502 25309 64625 64026 116554 25576 56011 116590 287606 25577 353316 313017 171378 140734 246142 690675 492821 56010 24888 58945 29748 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) 84495 299112 298098 288003 362385 116468 25737 304573 288414 362600 290027 59294 84490 25591 79116 29240 83507 170841 680915 367090 315344 81528 305957 289758 89809 59102 361698 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 97%10230234 Interferon alpha beta signaling 359726 298205 89829 686326 298210 25622 305896 288264 100912032 100911527 690894 50522 312688 64156 502959 24697 24481 100361294 24917 120103159 116689 192255 120103158 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-RNO-1300645.1 Acrosome Reaction and Sperm:Oocyte Membrane Binding 24936 499152 100362588 24163 CHROMOSOME MAINTENANCE%REACTOME%R-RNO-73886.1 Chromosome Maintenance 298850 306264 363198 288003 684439 116468 289150 361416 290805 25737 288414 85241 308755 303238 290232 297758 294025 500054 307798 307861 59294 364996 84490 295052 25498 171121 114494 309144 83712 361698 302783 65137 308839 288272 24829 689399 306945 689296 316602 24828 499873 313048 287432 297483 170944 499709 367645 691534 301965 362288 287273 362548 685909 680615 365877 681185 303175 306464 679342 64627 690795 289758 307805 301323 25448 305270 89809 59102 315164 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-RNO-349425.1 Autodegradation of the E3 ubiquitin ligase COP1 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 300711 192255 81827 24842 83806 311078 287772 292766 100912032 29669 29668 360860 29425 64156 100360846 117263 25581 29666 303353 365388 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229098 Interleukin-1 signaling 314870 117022 361677 301059 287772 292766 29669 29668 29425 64156 100360846 25742 116725 117263 25581 311245 29666 309452 303353 309295 365388 310877 117262 363520 85492 291921 64044 287984 313121 300177 65138 287707 94198 29673 50522 29671 84351 29670 29677 305549 60582 29676 29675 315599 500900 192255 309157 114495 81827 116596 287280 83806 362418 311078 308267 361765 291861 113894 100912032 25466 317546 81736 25493 312688 24493 54226 309361 303024 303604 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-RNO-9772755.1 Formation of WDR5-containing histone-modifying complexes 316328 314704 303539 362093 301164 29417 310958 289881 100359816 293500 498112 300206 291440 100362634 102550344 313323 207118 311575 314964 299569 360581 311468 304794 26295 362414 293488 310194 315606 360642 362224 290829 309001 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%10228832 Initiation of coagulation cascade 29243 260320 24946 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%10230710 Ficolins bind to repetitive carbohydrate structures on the target cell surface 64023 64459 114091 G0 AND EARLY G1%REACTOME%R-RNO-1538133.1 G0 and Early G1 114494 81758 100360427 295052 362485 305171 292787 680111 297893 361178 313048 25255 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 97%10231596 Azathioprine ADME 60423 63997 140944 494499 301005 295088 494500 65194 295378 24421 362329 24422 501110 690050 497811 363875 24465 83782 116721 191575 170924 CHROMATIN ORGANIZATION%REACTOME%R-RNO-4839726.1 Chromatin organization 316328 363026 306571 60421 363292 84578 25573 313539 301442 301128 81781 102554884 292019 315210 365755 302711 291295 303470 303514 298595 296501 29520 100359714 317464 54282 29512 29511 297597 310352 688634 299305 84401 680891 245957 290284 84353 313583 100362346 290614 310614 361724 689883 290669 362834 64520 304832 83789 297093 294924 83724 100366024 365155 362831 689954 679713 306764 310638 308345 361688 290831 498295 291844 299295 289372 364785 302553 500569 689820 297893 94201 81647 83712 50659 292404 288563 315606 293514 361402 298144 309452 290925 301235 303518 64646 291794 295384 290829 297867 444984 58919 368001 292622 363481 502125 302783 296732 89820 299186 83833 361374 362981 361295 301020 24829 361925 312974 306945 305589 361825 311607 303511 192352 24828 687711 307362 361711 317432 362093 305501 313048 293038 317425 312440 83726 684297 300389 360609 689582 308738 304809 291940 682469 64622 363064 293184 117056 100362099 113984 266670 361531 304495 406195 681031 303060 680498 81785 363630 103689969 100361269 103690021 360665 360804 685909 192246 680615 287876 65027 310769 365877 303607 171365 100359816 680737 300837 305479 300206 100362634 303175 102550344 688041 311575 287768 81736 117535 299620 64627 295270 362825 497941 690795 360531 304794 84481 26295 293668 83618 314205 310194 84486 360642 309001 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-RNO-179419.1 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 117262 85492 54237 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 64515 83806 297176 295052 311078 287772 292766 100912032 29669 29668 114494 29425 64156 100360846 361831 117263 25581 29666 303353 365388 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228328 Creatine metabolism 24265 117100 50676 81660 50690 79213 24264 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%10231258 Activation of the TFAP2 (AP-2) family of transcription factors 114491 313596 64466 299810 114490 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 97%10228714 Response of endothelial cells to shear stress 29597 25026 117104 24185 81745 25029 64199 25614 79218 24627 245986 60449 293508 66026 294962 311860 25521 24511 58966 25725 83579 680149 58979 24244 114117 24400 29156 81666 81667 29154 29699 315648 81662 309295 296648 29302 305679 84351 296456 315189 310131 363014 56611 24672 24600 117281 64226 81736 25493 56718 309361 24697 NUCLEOTIDE METABOLISM%REACTOME%R-RNO-15869.1 Nucleotide metabolism 116593 81656 287368 65135 312373 311580 64045 290741 294521 313560 298410 102238592 58964 362720 24183 116484 24184 311833 299976 685579 29223 83782 191575 365985 29261 619580 497778 25095 362015 290029 192357 79127 24165 117533 24465 25028 297389 25368 292072 291585 289801 304944 295620 315219 311864 362638 291824 85260 64467 309390 316077 613267 314312 287420 65156 301005 288259 315150 295088 311422 81643 171047 361068 24240 100363253 684425 117544 361274 288051 287406 305149 362329 313574 289276 117260 140946 298881 497811 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%10229948 Reduction of cytosolic Ca++ levels 29600 24244 29599 29598 29715 116601 140447 25391 140448 29693 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%10229900 Thromboxane signalling through TP receptor 294962 301512 83579 680149 24816 58979 64199 114117 303634 24400 79218 81666 81667 245986 81662 60449 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-RNO-9855719.1 Regulation of FXIIa and plasma kallikrein activity 295703 300250 29681 681544 24153 25087 50692 306761 CLEARANCE OF SERATONIN%REACTOME%R-RNO-380615.1 Clearance of seratonin 29539 25553 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity 29386 297893 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230652 Scavenging by Class B Receptors 25081 117254 25073 54225 94195 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231414 RHOBTB2 GTPase cycle 315265 306004 117259 297406 81822 299809 301555 361813 360596 140922 114612 302855 315840 299331 301252 300838 81634 114562 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-RNO-879518.1 Transport of organic anions 259248 432363 24221 58978 140860 170698 140915 84511 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling 303539 689844 310405 156726 679028 303101 301164 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228324 Tryptophan catabolism 50567 66029 681319 116682 59113 50719 29416 311844 64206 315439 56823 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation 66017 25444 29349 54250 25317 29369 29368 170700 116499 60464 170583 289625 25114 170582 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%10228358 Metabolism of RNA 689116 298075 303831 171350 313450 288588 266713 316123 502227 690966 361365 84389 289561 292778 288651 361580 294693 83503 117017 291703 498109 363633 305884 293058 308968 25578 313131 302855 24468 296320 291534 315170 288701 313433 313308 362153 300361 363005 292535 363064 294711 296219 293862 114612 100361269 312474 288718 500242 192246 308650 25594 361990 302670 303607 363151 85434 60376 305479 140931 690585 307410 171552 301432 361887 303057 498171 499020 688288 287768 29497 299620 295270 304277 498600 290666 291877 289315 64510 89819 361542 362990 84486 292729 361788 300687 366693 300208 294232 687575 501926 368070 117259 305586 295334 311670 497967 299256 501285 299811 362098 361449 289582 363082 259170 297522 302969 494445 89827 79227 29578 360803 81781 300996 307947 313030 294783 29667 313035 59087 298342 79256 501621 292019 292810 64200 83624 362687 310687 290519 499314 319110 287113 361808 100910202 291295 317612 314336 500790 117280 117282 295428 366276 246216 291060 689890 500538 298385 360726 64462 361814 303346 287530 366163 287415 362361 681062 297695 245976 309651 313588 360972 307474 84401 116697 691538 295284 680891 361035 311855 367930 683927 245957 302557 24472 304859 362819 290284 362260 365407 313449 314417 690303 305714 362152 362394 686980 80846 313583 314313 311166 679890 170933 361859 290614 366468 501688 293408 56011 64156 301226 25383 498251 170912 50522 289014 361201 192255 24672 117281 100912032 85252 79426 501582 24420 100125373 287596 691397 287522 365215 361271 24185 360855 684558 307503 24668 291317 170538 291434 81729 25347 29304 25348 28298 313707 305258 65136 360828 24680 27139 64205 26962 289809 313167 294282 310720 307446 300092 100910714 292067 363134 300032 288661 362967 681429 314836 363854 117053 100362640 170956 64298 319113 161477 25379 289810 306137 290641 296865 192180 359727 303608 94266 362214 360552 305076 314617 310019 315705 140654 85432 140655 60373 366017 361923 134480579 102551819 117042 287120 287122 291987 499782 294975 103689992 297685 291061 140661 29258 140662 29257 362902 362229 300079 291996 292964 293418 317399 290660 291071 81768 360629 500305 100361974 81775 294595 81776 297455 266605 314713 362631 500988 360760 679140 313744 361399 361736 360574 360572 498934 81773 364624 81774 361262 245981 497860 81770 300944 29344 300045 361109 308201 117104 290556 691531 64640 83789 361159 81764 686999 81765 81766 122799 114021 81767 29236 81763 312706 300050 690297 100361060 309301 58927 293828 292747 689284 288647 100361756 100360664 368084 29288 29287 29286 29285 316317 124323 307850 29284 287772 29283 29282 292766 296709 289740 64302 64306 29669 314830 29668 100360439 64307 58822 29425 100360846 298065 314545 122772 117263 361452 25581 134486107 362703 29666 361977 363237 303353 362426 365388 294429 291794 287830 291874 362281 117262 113975 85492 685068 499391 292085 295692 117021 362335 287984 84404 687711 65138 363462 366016 58958 94198 691231 65160 29673 362557 65274 29671 113929 29670 100362099 64301 29677 681031 245922 29676 81738 29675 362688 683983 53372 316108 25497 310769 499974 84473 81827 312947 171365 680737 83806 311078 117045 81635 25367 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-RNO-5656121.1 Translesion synthesis by POLI 309812 288003 116468 25737 288414 100912032 50522 64156 316344 89809 59102 192255 313702 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 97%10228476 Formation of editosomes by ADAR proteins 81635 25367 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-RNO-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA 298942 361272 299201 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231312 RUNX1 regulates estrogen receptor mediated transcription 24890 50662 361391 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%10231220 MET activates PI3K AKT signaling 170911 24553 361388 24446 25513 81504 UREA CYCLE%REACTOME%R-RNO-70635.1 Urea cycle 59085 497840 29215 306840 306574 29221 25611 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-RNO-379397.1 Enzymatic degradation of dopamine by COMT 308868 24267 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 97%10230000 Post-transcriptional silencing by small RNAs 192178 303774 308971 298533 NADE MODULATES DEATH SIGNALLING%REACTOME%R-RNO-205025.1 NADE modulates death signalling 24596 117089 310738 25402 29753 64314 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%10228782 Platelet activation, signaling and aggregation 50693 25441 682967 293886 94168 289316 25666 308291 497978 24816 81504 25673 499913 25614 24795 25150 114095 313845 311795 25651 84491 307396 246328 308875 299909 309207 25266 63836 293676 294643 113947 25373 364206 24648 29302 114111 89811 360457 83785 302470 25414 691992 295347 502858 25259 116727 24697 24446 360918 25524 25083 25087 81634 293860 81515 117273 60327 83805 25313 313050 24482 24703 84590 24617 24791 246358 50689 301512 25262 116590 54226 54245 25578 81745 24185 64199 24174 286924 24175 79218 25265 245986 60449 64803 294962 25686 25643 25622 83579 25513 680149 85243 58979 24244 64373 170538 114117 24400 81666 60664 81667 85385 24681 24680 29340 81662 116689 81664 81803 81804 25023 170911 25155 303634 59086 81809 25717 25387 24483 25679 81678 360942 316531 295378 81511 363104 60395 29337 24189 25388 363875 29636 116498 170924 24366 24367 685269 29434 59326 171337 361714 24936 304805 25081 85253 309609 24944 305021 54248 56782 361196 54249 315707 363015 81749 500152 688705 100359512 24825 498299 298947 445442 29254 497931 686539 29583 497932 24153 116510 363195 305795 305679 307986 24786 116635 54404 312159 360950 287876 140656 296488 24614 24186 29186 64465 24628 54320 245955 315989 304983 24854 500336 81814 684555 81821 295703 116662 140866 100361138 140594 309186 681544 293628 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-RNO-1663150.1 The activation of arylsulfatases 303631 315222 24800 365619 310326 362409 307404 25227 311013 SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-RNO-9938024.1 Somatic hypermutation of immunoglobulin genes 309812 316235 81685 288003 116468 81709 399679 25737 294339 288414 100912032 50522 305000 289758 64156 316344 296320 89809 192255 313702 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME%R-RNO-9648025.1 EML4 and NUDC in mitotic spindle formation 298850 681050 83836 295661 363059 363198 304951 684439 289150 361416 304477 29564 65201 297522 83572 313861 315648 294429 287830 292085 25515 287624 94266 309179 299147 252902 363193 312754 24673 29489 81738 362548 683983 29648 363174 24672 64515 681185 297176 298594 114592 170845 117281 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 85252 307805 81655 311191 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 97%10228600 RNA Polymerase III Transcription Initiation From Type 2 Promoter 301246 685539 294687 114205 311487 310685 361102 117526 685465 690254 316810 83503 306012 498109 362095 313914 690966 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%10228196 DNA Damage Telomere Stress Induced Senescence 302783 85482 24708 192218 24829 306945 24828 362485 300711 685909 680615 290232 297758 116685 365877 500054 291145 307798 304569 302935 307861 94165 24437 363849 24842 680522 295052 201097 84017 117062 684828 64012 303175 83571 114494 64627 690795 64046 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-RNO-399719.1 Trafficking of AMPA receptors 140724 84591 140725 60355 25023 25400 84016 25252 84347 315840 24245 24246 59317 29495 116563 171140 140670 50592 29629 29628 29627 65046 363447 171571 140729 24681 24680 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-RNO-8932504.1 DAG1 core M2 glycosylations 362567 84430 688673 114489 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230268 Negative regulators of RIG-I MDA5 signaling 50522 292892 311430 299827 64156 312937 315599 192255 246244 100912032 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-RNO-9943965.1 CHD3, CHD4, CHD5 subfamily 302783 24829 306945 303511 24828 307362 305501 293038 313048 300389 360609 297093 25573 291940 64622 113984 117056 406195 680498 303060 301442 360804 685909 680615 365877 100362346 310614 303175 361724 297893 290669 362834 64520 117535 64627 690795 100359714 83712 50659 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling 266610 64044 117279 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 97%10231186 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 294962 295230 116549 29374 297406 299809 83579 64013 363658 54296 24400 81667 81650 24818 60449 288305 29481 294864 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME DATABASE ID RELEASE 97%10229564 C-type lectin receptors (CLRs) 25441 100361818 361400 24605 24674 293621 24675 81745 24525 641452 25150 29337 29431 29432 307366 288375 293508 287772 292766 81515 83805 29669 24244 29668 170538 29425 64156 100360846 116725 117263 25581 24703 311245 29666 309452 303353 309295 365388 117262 85492 64044 25155 287984 313121 65138 94198 502902 29673 29433 50522 362432 282817 29671 84351 64171 29670 450223 29677 29676 29675 192255 81827 287280 83806 311078 308267 361765 100912032 117553 317546 81736 25493 309361 361831 303024 360640 360647 29748 83477 NGF-STIMULATED TRANSCRIPTION%REACTOME%R-RNO-9031628.1 NGF-stimulated transcription 117535 314910 114090 501099 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 25578 25203 295052 54237 114212 25576 307511 56011 25577 313017 308937 29753 114494 56010 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-RNO-450321.1 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 500133 116554 363520 362418 308267 313121 50658 362491 363855 317546 25272 116725 311245 309295 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%10229434 Beta-catenin phosphorylation cascade 24672 84027 117281 24205 309179 299147 79257 363193 312754 24673 501584 113927 84353 103691373 315648 679110 CELL CYCLE, MITOTIC%REACTOME%R-RNO-69278.1 Cell Cycle, Mitotic 363059 311802 308768 306102 306599 366403 406168 684111 29564 361088 65158 308870 81740 192228 25573 399489 81758 297522 29479 363055 301442 305467 498266 294010 29214 500069 692032 25164 494444 307947 290626 305882 309098 315423 171566 682033 59294 367153 311860 315508 300149 295052 314787 361613 683722 292787 361916 361643 360672 308064 100362495 362980 498265 311573 293844 313861 310344 114494 311529 362203 307169 287929 246150 305171 300963 60336 308663 252921 64462 680991 60347 361698 25255 307347 365191 309179 299147 312754 29167 140734 266713 361831 58945 84389 282834 117103 315740 25233 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 689820 297893 81515 361308 83805 363720 64528 64156 304813 315648 24514 116670 246772 64193 24708 294790 310806 292263 50522 50689 363193 252902 24673 362548 192255 24672 287280 290668 117281 361765 116590 171103 100912032 307585 29414 85252 303024 360908 301323 299331 288532 316273 59102 295596 296178 29728 312046 313138 313479 299112 364419 298098 292071 362385 312538 291927 307126 360621 304573 24185 362304 301430 85241 29753 301252 83572 499655 679886 361907 366275 307511 171102 300126 308937 287101 83571 24680 290577 304218 313304 25203 680014 63996 316737 54237 684771 691979 25023 305343 287447 25437 25515 114087 299204 94266 29648 116685 363174 64515 681185 297176 298594 114592 170845 305392 680089 308443 362519 303037 306464 362438 679342 296137 291441 24669 257649 257644 64041 287598 317252 289758 307805 311191 114764 500545 25448 305270 363028 89809 292058 286993 307639 102555739 315164 499914 114514 290842 298850 681050 83836 295661 363198 304951 288003 682908 64158 311546 684439 500377 116468 289150 117104 361416 304477 307833 246118 500363 25737 300218 498736 65201 288414 316531 307351 291081 84509 313478 679312 296554 85265 29213 362700 500929 84490 287772 292766 94201 29669 29668 56010 29425 100360427 58822 100360846 117263 25581 29666 81650 680111 303353 361178 294429 365388 287830 58919 291874 363481 362281 302783 117262 113975 85492 292085 295692 24829 117021 689296 362335 306945 287984 287624 316602 24828 65138 366016 58958 317425 313048 94198 287873 29673 362557 65274 29671 299850 113929 29670 246294 81754 29677 64033 29676 245922 29489 81738 29675 685909 683983 25193 680615 53372 25594 25497 365877 499974 81827 116549 24842 83806 311078 303175 114483 64627 690795 81655 24917 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-RNO-442380.1 Zinc influx into cells by the SLC39 gene family 305846 295455 294281 314637 361986 300051 291733 306009 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-RNO-186712.1 Regulation of beta-cell development 84482 29414 25233 24185 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME DATABASE ID RELEASE 97%10228368 Formation of the ternary complex, and subsequently, the 43S complex 682390 81773 294282 298700 81774 691947 299872 293427 681429 117053 100362640 288516 299899 691531 161477 83789 94266 122799 29236 140654 140655 100361756 54318 29288 29287 29286 29285 103689992 124323 29284 29258 296302 299027 29304 64156 25348 292762 122772 362952 81775 81776 65136 292148 27139 300069 293484 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10229748 Cell-cell junction organization 83427 63879 83501 25066 25150 292064 25507 313806 100361294 362850 316639 313474 25125 360652 301334 304297 84353 81679 311163 300289 25751 362279 314641 50654 83502 25697 266758 363875 60371 293142 84430 688673 25705 81717 500569 689820 287772 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 29425 64156 100360846 116479 54281 24790 83712 307237 117263 81918 25581 29666 81650 24514 303353 365388 302783 117262 85492 192275 24829 306945 287984 24828 65138 313048 94198 29673 50522 305679 84006 100188932 29671 361866 29670 117056 29677 680498 29676 29675 685909 680615 192255 365877 686092 308417 81827 304109 64465 116549 26955 498515 83806 310174 311078 192248 117048 313648 192183 303175 360687 498281 688041 301887 29181 100912032 84407 497229 24498 81736 303068 300445 361432 363058 29144 25409 64701 64627 29606 500870 78947 690795 29163 29162 293721 360882 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231410 RHOBTB1 GTPase cycle 261736 308968 81818 25537 117259 360915 171115 297406 299809 301555 361813 140922 302855 315840 365407 117039 313216 309722 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-RNO-9958517.1 SLC-mediated bile acid transport 295417 85426 289459 294255 85254 363024 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%10231782 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 245981 497860 81770 64640 81807 81764 81765 641452 81766 64525 81767 81763 100361060 58927 689284 312199 289508 287772 29283 292766 29282 296709 64302 29669 64306 291434 29668 81729 100360439 25347 64307 29425 64156 100360846 28298 117263 25581 134486107 29666 64205 303353 26962 365388 117262 100910714 85492 64298 287984 65138 290641 94198 29673 50522 29671 29670 29677 29676 29675 192255 361923 134480579 117042 81827 287122 499782 83806 311078 140661 140662 29257 100912032 300079 292964 293418 81768 100361974 361831 362631 360572 G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition 311802 308768 306102 306599 366403 406168 361088 29753 81740 192228 29479 363055 305467 294010 29214 500069 692032 301252 83572 290626 305882 309098 315423 361907 171566 682033 367153 295052 314787 361613 683722 361643 307511 360672 171102 300126 308064 100362495 362980 308937 287101 311573 293844 114494 310344 311529 362203 287929 246150 300963 308663 252921 64462 680991 60347 307347 25203 54237 25515 363174 29167 311191 266713 114764 58945 84389 83836 117103 64158 311546 117104 316531 85265 296554 29213 287772 292766 29669 29668 56010 29425 58822 64156 100360846 117263 25581 29666 304813 315648 303353 116670 365388 117262 85492 689296 287984 316602 65138 94198 29673 50522 29671 29670 299850 246294 29677 29676 29675 29489 24673 192255 25594 81827 24672 287280 24842 83806 311078 117281 361765 171103 100912032 85252 303024 299331 SMAC (DIABLO) BINDS TO IAPS%REACTOME%R-RNO-111463.1 SMAC (DIABLO) binds to IAPs 64026 100360940 63879 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006934.1 Signaling by Receptor Tyrosine Kinases 25267 689116 24629 298075 25692 24605 293621 306628 81504 24525 297930 25614 25150 313845 315992 290905 29578 311331 360658 292770 29135 50866 25266 64200 313388 140583 94203 300955 81922 25443 679934 313474 296648 29348 25589 361388 170579 81527 170633 286928 114110 117542 29302 114111 89811 60352 498798 362513 360457 296456 315189 310131 29183 79249 84353 310688 83785 79129 24506 66021 24505 294568 315348 314612 81679 81921 246331 116563 308666 362271 311163 313024 25414 58823 682937 311030 170851 29622 295347 366061 64022 288588 316123 24553 24697 24446 312574 690966 296121 117063 361365 289561 292778 25233 83503 303517 117017 309816 498109 691517 363633 29613 170897 287155 140670 56011 297893 81515 117273 83805 25433 25313 313050 24482 361396 59109 64156 310738 364686 84357 64030 315648 24514 81771 117269 24329 58960 170921 25532 64535 499349 50522 50689 289014 363193 24673 315994 192255 315305 79121 294981 501560 64019 24672 306141 500873 301512 311598 24600 117255 300980 360820 117281 64624 116590 361120 100912032 25467 117535 314910 114090 24890 29414 300078 116663 60587 54245 117277 24918 299331 25326 29376 59325 500409 362950 307810 81745 361655 24185 84578 287942 361597 84477 500985 84427 56084 293508 25718 60427 366275 84492 25622 25522 25513 305539 85243 296072 360903 24244 170538 25613 25507 60664 85385 116548 24680 29340 116689 25023 170911 50646 25125 25126 311567 292406 303882 25489 679566 24924 79429 66018 81517 116478 363616 266802 362814 301737 315829 100910984 315761 116743 316213 314850 83800 54241 24483 295378 25738 297932 29431 363131 29432 298103 366962 363875 25700 246273 84489 29516 29757 289407 361992 25627 83504 362802 65052 368044 296981 298451 299971 24511 66017 83615 25444 170667 29349 436582 54250 498416 297566 25317 29369 312488 117596 25022 171337 29368 94170 170700 116664 116499 366545 85253 60662 360406 60464 170583 81737 289625 25114 25054 170582 54281 25730 24225 315707 25353 79114 114562 299236 83823 499308 29610 366205 29496 360606 498596 432361 298787 501099 24827 445442 300802 25676 500526 81687 114486 29433 29192 292788 114203 316369 363014 81751 64465 24628 114559 140931 25537 64226 289231 29497 65046 56718 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%10230058 Ion influx efflux at host-pathogen interface 84355 316519 24941 NEUROFASCIN INTERACTIONS%REACTOME%R-RNO-447043.1 Neurofascin interactions 83841 116690 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228518 Glycerophospholipid biosynthesis 681694 288025 361676 289733 361433 293711 114101 360426 314075 296048 311341 691478 362434 313997 498741 361694 25062 361467 363521 25096 286936 680971 295417 678749 296623 316039 310773 361686 29367 85311 89841 171155 60666 360843 170670 29194 298504 170919 29510 85254 362249 362058 81650 363159 311821 305166 296130 690610 316737 29653 294255 84497 252900 29254 304474 287467 25511 288322 287115 25097 287366 114561 140544 81925 362039 116549 691905 29354 294324 24913 290843 29692 366196 308309 295631 84470 314553 298579 29526 192259 29359 192260 297694 362702 302425 293620 296128 361401 362972 363024 GASTRULATION%REACTOME%R-RNO-9758941.1 Gastrulation G2 M CHECKPOINTS%REACTOME%R-RNO-69481.1 G2 M Checkpoints 316794 312046 313138 313479 25578 85482 192218 312538 114212 291927 290805 307126 360621 298534 362304 301430 287927 685055 310034 29753 308755 361815 306734 300711 690043 297627 296099 295052 360588 497856 307511 64012 171102 300126 294800 308937 287101 114494 498411 308669 291787 289468 100361529 140583 362827 25203 362704 54237 288003 116468 288414 305000 25576 56011 287772 292766 25577 313017 29669 29668 56010 29425 64156 100360846 116725 117263 25581 29666 303353 365388 117262 85492 24829 306945 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 24842 83806 311078 303175 100912032 497672 64557 64627 363924 303194 315969 360908 288532 316273 290997 59102 295596 64046 290631 296178 29728 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8934593.1 Regulation of RUNX1 Expression and Activity 58919 50662 361391 64033 25622 25193 114483 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 97%10230902 Phase 0 - rapid depolarisation 24239 140725 140727 140729 50688 300992 116600 140728 CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress 85482 192218 361940 29564 297522 294010 300711 25309 25164 494444 365057 294917 291671 79462 295052 26195 171335 64012 654441 303393 26198 84683 114494 94194 688386 681024 100188937 54322 360229 303333 24472 25282 314638 79129 304962 66021 29445 303016 24963 60460 29167 102555170 140734 690675 81920 252934 498013 361831 58945 54225 25400 25233 366381 292588 293155 296368 64862 361389 288671 290875 116484 362485 305420 360643 290232 297758 24565 500054 307798 307861 298282 299121 309757 64156 25747 314322 24208 81771 117269 296732 29260 24708 363855 25272 50522 50689 84006 24516 289014 252902 84478 315994 497991 140639 192255 114495 501560 83619 116554 287280 361765 50658 116590 113894 100912032 448830 24890 29414 113898 85252 299331 59102 307480 27137 298203 114766 363026 29702 24185 84578 361810 29753 500843 100362347 502988 360497 362573 24426 362441 690751 360969 84428 303185 301252 24245 305464 363138 24246 294515 304410 291145 29338 304569 362809 302935 260321 94165 24437 25154 363849 680522 201097 25506 365755 298576 302711 84017 24413 171140 117062 684828 304798 83571 308901 25617 116685 24253 24404 50551 303878 286899 362293 25352 65028 24356 85431 293524 292721 94167 25420 84485 307997 304127 297998 297994 311427 690038 24468 64317 266759 293103 79245 288444 113919 307133 113906 25672 298376 294744 25261 117254 116456 300721 259233 81800 171562 500907 304063 366734 316101 64371 171361 24874 29734 81807 29560 114490 64345 641452 64525 29452 54702 85265 192277 308457 297932 298103 83724 25242 289407 362802 54318 368044 24440 360504 298451 299971 170667 436582 297566 296302 287772 292766 312488 117596 94201 94170 116664 366545 25081 29669 24360 29668 116599 24451 299027 79239 29425 100360846 292737 83712 117263 25581 29666 303353 294429 365388 287830 291874 362281 302783 117262 113975 85492 292085 295692 24829 117021 362335 306945 287984 24828 65138 366016 58958 313048 94198 293615 29673 362557 65274 24787 29671 299850 113929 29670 24786 117056 29677 680498 363630 29676 245922 29489 81738 29675 307151 116643 685909 683983 313038 680615 53372 309626 25497 365877 24186 499974 310258 303730 312947 81827 315136 311545 24842 83806 292887 311078 308869 84027 310091 298514 501403 303175 64226 295357 114483 688041 500336 301555 297960 26954 117044 117043 64627 362045 690795 56718 360776 81655 24248 64046 89842 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 97%10231020 CLEC7A inflammasome pathway 282817 64044 307366 NADPH REGENERATION%REACTOME%R-RNO-389542.1 NADPH regeneration 50655 24479 DS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022923.1 DS-GAG biosynthesis 29139 50568 25181 286974 365583 297865 361450 25393 81651 114122 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 97%10228942 Gamma-carboxylation of protein precursors 25268 29243 260320 25295 306608 81716 24946 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-RNO-6814848.1 Glycerophospholipid catabolism 306460 360753 60418 LGI-ADAM INTERACTIONS%REACTOME%R-RNO-5682910.1 LGI-ADAM interactions 140724 29495 84347 140725 140729 306013 305417 57033 252892 24923 116470 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-RNO-451307.1 Activation of Na-permeable kainate receptors 54257 29559 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-RNO-6807505.1 RNA polymerase II transcribes snRNA genes 83830 360589 689116 309638 298075 289561 292778 305120 288533 373541 300782 288514 294018 298681 303918 117526 690728 83503 298688 117017 295448 498109 363633 362813 362110 311414 686980 361988 100364568 311591 289382 304204 362537 304758 288588 24790 691379 316123 171068 363227 500715 83828 296102 690966 361365 81673 286917 361057 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-RNO-1253288.1 Downregulation of ERBB4 signaling 297930 50522 64156 25489 192255 100912032 83805 311567 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-RNO-9027284.1 Erythropoietin activates RAS 29376 85385 81515 24514 287942 24335 81504 APOPTOSIS%REACTOME%R-RNO-109581.1 Apoptosis 25578 78963 295961 58918 100360940 63879 64159 83502 298534 307562 29753 25614 498072 171528 266610 259274 25402 306886 306871 116502 25309 361092 64625 83497 60371 24170 291145 304822 64026 317589 296654 81818 305884 25311 24437 298282 680522 84359 201097 316164 171116 367786 684828 25576 114114 56011 287606 25577 353316 313017 171378 246142 492821 170538 56010 25318 24888 363328 60350 64639 29260 292994 64044 364867 50689 24205 64547 291755 84353 246097 117279 25385 246756 116685 116554 116590 140734 690675 448830 58945 24917 29748 ACETYLATION%REACTOME DATABASE ID RELEASE 97%10228912 Acetylation 290681 116632 116631 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding 289625 25114 170582 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism 25736 25679 312670 81678 64199 24654 171078 24175 79218 25083 246253 245986 60449 293508 85240 294962 64532 25297 25521 25686 25289 25725 300992 116600 83579 59326 64524 680149 24953 83535 58979 24778 114117 24400 289036 81666 81667 29699 83688 24680 81662 81664 25398 64562 246153 307234 25262 373545 25559 24239 295347 83588 114024 113976 266607 25051 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%10228982 Mitochondrial transcription initiation 289307 83474 ACTIVATION OF TRKA RECEPTORS%REACTOME%R-RNO-187015.1 Activation of TRKA receptors 59109 310738 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%10230518 Autophagy 364419 29564 60445 300711 64670 679886 312647 299827 360827 361916 24855 365191 114558 83529 83532 83531 299514 266601 298575 685620 363254 300075 308416 304017 140734 81920 58945 282834 192647 641452 56816 64862 363131 24255 363836 65052 678769 313391 171415 300240 362164 316640 83805 117287 363720 65248 59319 305482 360682 363278 686505 308846 64156 303554 689161 304579 116725 302559 312634 305831 81650 288498 312927 499973 64562 287873 50522 246294 252902 29489 58974 288731 362245 361321 363442 192255 365601 25520 116549 83803 308869 310091 312703 298514 64226 295357 373545 113894 100912032 297960 26954 117044 117043 362045 56718 360776 81655 CD28 CO-STIMULATION%REACTOME%R-RNO-389356.1 CD28 co-stimulation 298947 497931 170911 296648 25233 497932 81745 24185 25660 25408 81504 29433 25150 309179 299147 366508 363193 312754 315189 29431 310131 29432 24673 366962 363875 246273 361992 116596 24672 64465 117281 64226 25513 81515 85243 83805 313050 29414 56822 56718 60664 360640 315648 SPRY REGULATION OF FGF SIGNALING%REACTOME%R-RNO-1295596.1 Spry regulation of FGF signaling 306141 24672 25622 117281 116590 100912032 500526 81504 83805 114486 50522 50689 64156 24673 500985 192255 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111447.1 Activation of BAD and translocation to mitochondria 25578 56010 64639 25576 56011 25577 313017 171378 29748 29753 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-RNO-112314.1 Neurotransmitter receptors and postsynaptic signal transmission 25590 29422 29718 25103 54239 81721 25753 79246 54240 58963 64053 65024 298521 79557 64199 286924 54257 83506 84347 24611 79218 117284 24407 24406 81636 24409 245986 24245 24246 60449 25456 293508 24922 302950 59317 294962 29495 64532 25451 25521 25686 25450 25289 171140 25643 25725 83579 29241 25302 680149 29629 84420 58979 29628 29627 24244 79211 140675 114117 24400 64508 50599 363447 25050 171571 140729 81667 24681 25674 29699 24680 116560 81664 66013 60341 140724 84591 140725 65187 170945 25023 83613 192258 24397 29695 29694 84016 25252 171503 553106 58948 191573 116563 81657 60355 25400 315840 140670 50592 83633 81771 117269 24410 501560 24408 29709 29708 25743 170847 24412 65046 24411 116649 29707 29705 171131 24947 29559 29713 29712 PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis 29562 24689 314140 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%10229566 G beta:gamma signalling through PI3Kgamma 294962 298947 497931 25233 497932 83579 81745 24185 680149 117273 58979 64199 114117 29414 24400 79218 81667 245986 60449 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism 361730 684314 24188 25659 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229738 Nephrin family interactions 315546 25150 64563 100359836 300955 316369 310695 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-RNO-399997.1 Acetylcholine regulates insulin secretion 24654 85240 81666 24680 81662 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%10228276 Malate-aspartate shuttle 681896 25721 362322 81829 24401 309111 64201 24551 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport 503165 60355 363059 293502 315740 289168 79117 29564 360426 252889 117548 353302 294010 117550 84428 83572 60384 289397 300674 114113 309523 299121 246310 361308 85248 171291 84393 313254 84599 360953 171041 303575 362162 314473 289309 363123 361207 290659 300158 113886 297428 287624 361577 84379 304290 289350 294286 299850 309451 252902 81754 307039 29489 300888 140932 79120 64189 64310 114023 294324 304978 246209 171549 140940 140673 29167 65165 140734 316226 303659 296750 306809 81655 79214 58945 363288 314906 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%10230592 RHO GTPases Activate WASPs and WAVEs 81732 117538 297518 259242 300955 679934 367901 286928 81504 117542 25614 50689 360854 79249 363875 287876 288669 294568 289820 315348 308666 64465 311860 313024 58823 81822 682937 81824 54227 116590 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229866 Wax biosynthesis 293173 302425 679520 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 97%10230904 Phase 1 - inactivation of fast Na+ channels 65195 65023 116695 65199 56817 259243 65180 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME%R-RNO-9834899.1 Specification of the neural plate border HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%10230772 HATs acetylate histones 316328 306571 24829 306945 363292 362093 680498 83724 679713 315210 300206 303175 311575 303470 303514 64627 296501 317464 81647 83712 26295 297597 310194 310352 688634 360642 299305 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230730 Nuclear Envelope (NE) Reassembly 282834 364419 682908 64158 500377 117104 307833 246118 500363 300218 498736 316531 307351 291081 84509 25573 313478 679312 297522 296554 29213 301442 362700 679886 500929 361916 363720 287830 291874 246772 113975 25203 54237 292085 295692 117021 25437 362335 114087 365191 366016 287873 362557 81738 683983 116685 24672 117281 24917 DEPYRIMIDINATION%REACTOME%R-RNO-73928.1 Depyrimidination 680915 367090 315344 305957 81528 GENE SILENCING BY RNA%REACTOME%R-RNO-211000.1 Gene Silencing by RNA 302783 289561 292778 686774 24829 306945 24828 83503 117017 84509 498109 363633 117056 303774 680498 308971 64028 685909 680615 365877 298533 311130 303175 299284 363006 64627 690795 288588 192178 690966 361365 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%10230750 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 292892 84353 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine 680915 367090 315344 305957 81528 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-RNO-2173788.1 Downregulation of TGF-beta receptor signaling 29591 287155 83837 81516 100912032 50522 64156 59086 25631 192255 297699 29357 81810 AXONAL GROWTH STIMULATION%REACTOME%R-RNO-209563.1 Axonal growth stimulation 24596 310738 360678 117273 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 97%10228134 CDC6 association with the ORC:origin complex 313138 313479 291927 360621 362304 295596 301430 296178 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis 301221 64845 361300 DIGESTION%REACTOME%R-RNO-8935690.1 Digestion 64055 25702 25680 25711 25656 363465 497039 117554 289032 50682 113901 84028 SIGNALING BY FGFR3%REACTOME%R-RNO-5654741.1 Signaling by FGFR3 24605 293621 170911 361388 500526 81504 114486 24525 50522 50689 313845 25738 24673 500985 84489 192255 306141 24672 66017 25444 25622 117281 29349 54250 116590 25513 25317 29369 100912032 316213 83805 29368 314850 116499 366061 60662 60464 170583 64156 85385 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-RNO-379398.1 Enzymatic degradation of Dopamine by monoamine oxidase 24267 CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling 246331 289392 65208 84027 361597 140908 29751 309280 25150 25418 25415 25417 312213 25416 116671 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%10231536 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 367090 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230940 Intraflagellar transport 65209 289168 100362124 305349 303968 295654 116475 288585 300675 365153 312651 298767 503018 685284 362265 500571 362553 363286 300062 363544 296618 287541 498095 373066 295106 170714 313365 311123 314523 500086 299209 499814 85248 140734 58945 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 97%10231468 Biosynthesis of maresin-like SPMs 29277 25086 171522 24297 266682 252931 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-RNO-5685939.1 HDR through MMEJ (alt-NHEJ) 297561 290027 84495 84490 25591 85482 291787 64012 64046 288079 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%10228894 FXIIa, PKa activate coagulation factors 502858 25259 116727 25087 24946 306761 691992 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-RNO-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 316033 29640 296394 362924 502017 291325 363109 297393 25197 116696 498272 297417 498486 117523 360518 302972 81759 25547 83505 313139 311204 305291 365984 81726 298071 310935 114711 291095 501167 316642 360475 300668 362547 315212 117185 311530 300089 293587 302915 303692 407765 25280 301155 300741 287920 299346 313231 298541 311847 29758 295051 288525 294400 363103 304860 362031 364901 363040 64442 64445 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-RNO-192105.1 Synthesis of bile acids and bile salts 307096 25270 29725 25429 362360 298369 301517 25428 296461 79111 361266 311129 25541 246211 83724 303497 362782 364773 60351 83569 498790 79244 309527 65192 192242 498789 171516 259221 291283 191574 307092 PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 97%10229888 Protein folding 294962 295230 116549 29374 170897 297406 299809 83579 64013 363658 54296 24400 81667 81650 24818 60449 288305 29481 294864 MELANIN BIOSYNTHESIS%REACTOME%R-RNO-5662702.1 Melanin biosynthesis 310152 100365773 308800 290484 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs 287454 29527 81639 25290 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 97%10228372 GTP hydrolysis and joining of the 60S ribosomal subunit 81773 81774 245981 497860 81770 691531 64640 83789 308306 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 29285 124323 29284 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-RNO-164378.1 PKA activation in glucagon signalling 25521 25725 29699 293508 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%10230488 Organelle biogenesis and maintenance 311802 289168 366403 29753 81740 192228 29479 363055 305467 363272 294010 114089 29214 500069 25309 83572 290626 305882 315423 367153 314787 24717 683722 360672 308064 85248 100362495 311573 293844 310344 311529 246150 300963 252921 64462 83567 60347 307347 54237 306840 25515 25273 25411 314961 85258 24650 679894 24399 308443 81830 29167 140734 690675 311191 114764 58945 304007 287612 83836 117103 65209 64158 171044 307724 100362124 316531 305349 303968 295654 116475 26197 296554 64632 26196 29213 288585 60627 300675 365153 312651 298767 503018 100910342 171455 116654 685284 113948 362265 24818 50556 500571 362553 365770 288305 245709 363286 300062 294864 363544 500832 296618 316102 295230 287541 29374 498095 373066 299246 311456 295106 170714 362142 363760 313365 311123 299809 314523 361930 500086 299209 499814 689779 366872 252881 308923 363126 300880 303915 56010 680407 287383 100360427 58822 305287 361789 293148 296136 313170 287836 117515 361727 64664 266809 361178 309486 367714 245958 140608 300677 171082 94271 245965 171069 29754 362749 641434 690441 171375 192241 293615 65262 171374 361596 24787 299850 309451 362675 29489 79120 498102 117281 299979 298555 29885 313993 299331 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-RNO-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 58983 24942 25533 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-RNO-72613.1 Eukaryotic Translation Initiation 682390 298700 64514 691947 299872 293427 288599 303831 288516 299899 171350 308306 291434 81729 25347 29304 25348 28298 65136 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 81773 81774 245981 497860 81770 691531 64640 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 54318 29288 29287 29286 29285 124323 29284 296302 29283 29282 296709 64302 64306 100360439 64307 299027 64156 122772 134486107 50522 116636 117045 292762 362952 192234 108348073 292148 300069 293484 171145 117019 PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-RNO-169893.1 Prolonged ERK activation events 58960 56011 170851 116590 287942 314850 114486 295347 50689 59109 310738 54245 116478 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006927.1 Signaling by Non-Receptor Tyrosine Kinases 58919 29496 498596 432361 24329 59325 24605 293621 300160 25676 24185 25125 29560 24525 50522 500985 363875 192255 89829 366275 362271 117268 306400 170843 64015 25414 360820 296472 94201 100912032 117273 83571 25433 64022 25313 64156 54245 24697 312477 361617 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855196.1 IP3 and IP4 transport between cytosol and nucleus 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 294429 499974 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%10230532 Synthesis of PIPs at the ER membrane 300147 305419 116482 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%10228644 Nucleotide Excision Repair 83614 690244 299112 171525 289561 298098 292778 288003 288651 362385 360915 116468 497967 304573 25737 361580 288414 287927 294693 83503 117017 25573 291703 498109 363633 301442 499417 302502 290027 59294 25591 300813 64156 246216 116725 361181 287367 298012 293494 361698 366163 65137 84495 316440 245976 362258 291737 314061 361925 315523 362479 296084 360471 85423 306274 50522 300772 363273 287876 192255 313098 361381 362394 261736 363283 100912032 304719 288588 289758 266713 100362121 310707 502227 89809 117039 690966 59102 24919 361365 84389 SIGNALING BY PTK6%REACTOME%R-RNO-8848021.1 Signaling by PTK6 58919 29496 498596 432361 24329 59325 24605 293621 300160 25676 24185 25125 29560 24525 50522 500985 363875 192255 89829 366275 362271 117268 306400 170843 64015 25414 360820 296472 94201 100912032 117273 83571 25433 64022 25313 64156 54245 24697 312477 361617 CARDIAC CONDUCTION%REACTOME DATABASE ID RELEASE 97%10228812 Cardiac conduction 116601 50688 25400 688996 25679 170899 25391 276720 64672 81678 24211 29693 24212 24213 29600 63847 294141 29599 63848 65195 29598 65023 362013 65272 312981 29248 65199 56817 58971 64190 259243 308405 116831 29639 29132 58950 24245 24246 59299 171140 300992 116600 24590 83535 25560 113902 24244 689560 246150 140729 25650 64119 364241 89821 156873 140725 25390 29715 117018 140447 140448 114593 116564 289596 24603 59324 24602 116695 24598 116491 64120 25262 140728 25470 63883 681190 116489 24239 171138 116649 367302 140727 445371 84429 65180 84020 361618 29712 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 97%10231322 E3 ubiquitin ligases ubiquitinate target proteins 266712 297337 362412 308282 295568 116718 24829 293561 64460 306945 500636 307029 25737 287927 641452 305581 50522 29534 363064 293184 361531 192255 313216 363836 300837 81816 360748 312703 100912032 117044 81920 680424 64156 361831 116725 83477 304832 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 97%10231524 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 302415 60331 KINESINS%REACTOME%R-RNO-983189.1 Kinesins 300158 293502 113886 315740 289168 287624 294286 117548 353302 117550 289397 309523 246209 171549 361308 85248 171291 84393 316226 303659 313254 303575 171041 363288 314906 314473 289309 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%10228166 Processive synthesis on the lagging strand 59294 84490 289758 301323 25737 59102 85241 361698 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 97%10229362 Synthesis of dolichyl-phosphate 305291 288525 294400 81726 298541 311847 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 299112 171525 289561 298098 292778 288003 288651 362385 360915 116468 497967 304573 25737 361580 288414 294693 83503 117017 291703 498109 363633 302502 59294 64156 246216 361181 287367 361698 366163 84495 245976 314061 362479 360471 306274 50522 363273 192255 362394 261736 363283 100912032 304719 288588 289758 266713 502227 89809 117039 690966 59102 361365 84389 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%R-RNO-1234158.1 Regulation of gene expression by Hypoxia-inducible Factor 29452 25242 29560 114490 64345 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111446.1 Activation of BIM and translocation to mitochondria 116554 58945 64547 PI METABOLISM%REACTOME%R-RNO-1483255.1 PI Metabolism 314641 65038 50557 305419 288762 114554 116699 361659 307842 309855 316457 89812 171088 80849 310155 363131 114089 246237 65052 64633 308584 367786 25513 60418 94197 310663 85243 307428 305482 365865 500132 306460 282584 60664 317296 312634 116723 295674 306490 85238 298947 25532 497931 170911 81747 116482 497932 364629 116720 364298 84018 366508 114561 287533 301131 140607 64310 309419 360753 498331 360521 140940 300147 305935 361632 54259 289021 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 97%10230188 Ovarian tumor domain proteases 50557 500133 293705 24842 54237 315911 286761 362491 100360606 362788 100912032 363982 117273 50522 24205 24890 64156 500572 306886 361831 116643 311245 192255 309295 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%10231748 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 81679 304109 64465 311163 316639 50654 83502 100912032 25697 83805 50522 301334 64156 84353 363875 192255 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229620 Signal regulatory protein family interactions 25528 361537 499537 50646 29364 155183 81504 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%10231612 Regulation of Expression and Function of Type II Classical Cadherins 81679 311163 24790 84353 362850 300289 84407 303068 METABOLISM OF VITAMIN K%REACTOME%R-RNO-6806664.1 Metabolism of vitamin K 309004 313706 399684 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 97%10229128 Adenylate cyclase activating pathway 302950 64532 24611 64508 25289 81636 29241 84420 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%10231504 Signaling by NOTCH4 25578 24185 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-RNO-5099900.1 WNT5A-dependent internalization of FZD4 65046 116563 25023 140670 25388 24681 83800 24680 54241 64558 303251 116561 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis 84114 287380 84470 ACTIVATION OF C3 AND C5%REACTOME%R-RNO-174577.1 Activation of C3 and C5 24232 24233 406161 PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%10231558 Pexophagy 50522 64862 64156 303554 304579 312703 300711 192255 113894 100912032 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-RNO-380320.1 Recruitment of NuMA to mitotic centrosomes 83836 64158 311802 306599 366403 316531 29753 308870 81740 192228 29479 296554 363055 29213 305467 294010 29214 500069 692032 83572 290626 305882 309098 315423 171566 367153 314787 683722 360672 308064 100362495 362980 311573 293844 310344 56010 311529 362203 58822 287929 246150 300963 308663 252921 64462 680991 60347 307347 54237 25515 299850 29489 117281 29167 311191 114764 58945 299331 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%10228668 PCNA-Dependent Long Patch Base Excision Repair 59294 84490 299112 298098 288003 79116 362385 29240 116468 25737 304573 288414 289758 89809 59102 361698 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%10231630 Regulation of CDH1 Function 117262 85492 83427 313474 50654 287984 83502 65138 25697 94198 305679 29673 50522 25150 29671 29670 29677 29676 29675 292064 84353 192255 81679 81827 311163 83806 311078 287772 292766 100912032 83805 29669 29668 500870 25751 29425 64156 100360846 117263 25581 29666 303353 365388 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229878 Dopamine receptors 25195 24318 29238 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 97%10228684 GPCR downstream signalling 24605 25666 293621 287730 497978 24816 24938 81504 24525 25107 499913 25229 688605 689936 313845 29385 379044 282832 25340 554302 50672 25342 29141 60590 292409 64042 309207 53949 308408 294394 246759 29397 24260 25593 25111 292419 25323 81509 59264 63887 25569 297795 767613 25689 29363 54258 500157 84348 24232 305236 50577 289023 171551 24806 24808 24929 290493 292794 117549 24247 316259 192223 317219 25570 81503 29256 498289 362505 100360071 497196 100911796 64636 302619 299242 117264 57305 81657 353250 308163 84007 117027 57302 89810 100270683 360579 29581 171056 365228 306307 25555 29238 89808 81644 689869 29595 29237 192205 29235 365901 192206 170634 29597 29234 84475 29471 171044 360918 314386 24797 24677 25524 25083 114098 114099 81672 25087 294807 294075 25652 24323 24326 24448 81668 29335 301086 690158 24418 24659 266997 24417 59301 117273 83805 24419 24772 114105 24414 60628 24416 25504 24415 309212 25187 83633 78964 500091 171371 497942 192648 192649 246358 116637 25637 25516 408199 25194 310444 25075 316009 192646 310327 501177 500089 100310876 301066 25605 679957 140928 287910 298006 63885 25723 29407 81743 78981 78980 25262 78983 362454 78985 498335 366270 366274 29538 117029 245920 83518 24889 246219 266607 60665 29413 29412 78976 25298 679975 54305 78979 302378 25706 170926 24179 259224 259222 24613 25380 25264 24174 690448 24175 25265 363682 29180 288995 378939 691774 116677 64803 24182 25033 29191 287673 499194 113959 24717 25245 63843 25513 25248 170704 24953 25007 260319 60337 680188 58812 24604 60664 85385 502757 171104 171108 500101 83567 310869 29290 171101 58949 170911 25740 362477 308118 25387 25679 81678 295378 60395 29431 25388 29636 116498 29516 24511 298947 84009 497931 497932 24807 304109 64465 114559 25537 29491 81645 59075 50678 308776 309962 25233 367901 25433 24221 315648 81771 117269 24329 50689 363193 24673 363143 29481 501560 24672 117281 116590 29414 54226 81745 24185 64199 24654 286924 83506 24611 79218 24180 360616 24627 24626 25638 81636 245986 25238 24668 60449 25031 293508 302950 25372 85240 294962 64532 25521 25686 25289 25643 25601 25725 83579 29241 680149 84420 58979 140908 64373 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 29340 81662 81664 306618 66013 60341 29691 500608 317598 298404 287537 287418 310460 307098 120099896 246174 311647 363509 310635 310999 78966 140898 54296 361921 307398 309653 117020 303634 301334 295449 363460 310192 114513 293024 100362710 687105 362648 25320 54248 81749 688705 29254 406163 305795 29480 54289 54294 54293 54292 54297 81663 498246 301088 84583 100361166 59293 84022 114705 246254 362021 289076 81821 140866 100361138 66025 306792 60399 116744 29415 500317 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 361765 287772 292766 100912032 117553 29669 29668 29425 64156 100360846 309361 303024 117263 25581 29666 360640 309452 303353 365388 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%10228426 The phototransduction cascade 307401 499132 259274 317498 316218 85259 363143 291318 301233 29481 140936 64370 25539 116556 59077 79222 299521 81760 24717 83579 680149 64511 24244 24400 25318 289878 688297 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%10231294 RAB GEFs exchange GTP for GDP on RABs 362599 117103 361987 294709 363326 29448 25233 295333 24185 308942 367073 29753 84589 360797 266688 50645 299075 114638 292074 362983 501854 299799 363235 64633 290746 360827 94193 94197 361555 313493 315668 288700 84590 315059 680465 363123 691042 306229 25531 24942 84379 25530 312257 289350 25183 29662 81754 171452 307039 81756 287427 252916 246324 316017 29885 207119 309678 300147 307868 288779 29414 313340 311880 367915 315999 287709 315756 501550 360768 292760 311494 689102 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%10230110 Interleukin-35 Signalling 84405 29144 171334 680609 100361294 25125 24514 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230862 Positive epigenetic regulation of rRNA expression 306817 302783 303539 24829 306945 65261 24828 306274 117526 301164 83503 498109 117056 680498 685909 287876 680615 365877 301246 361784 84027 360893 361420 303175 368002 313245 680493 64627 362728 317399 83582 690795 690450 83581 60571 690966 84486 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%10230888 ATP-dependent chromatin remodelers 297093 25573 301442 81781 292019 297893 291295 100359714 83712 50659 292404 293514 301235 303518 291794 297867 368001 292622 302783 296732 299186 83833 361374 361295 301020 24829 361925 312974 306945 305589 84401 361825 311607 687711 303511 192352 24828 307362 361711 362093 305501 313048 680891 293038 83726 300389 360609 308738 291940 363064 245957 64622 293184 117056 100362099 113984 406195 361531 681031 680498 81785 303060 100361269 103690021 360804 84353 685909 192246 680615 287876 65027 365877 303607 171365 313583 300837 680737 305479 100362346 290614 310614 303175 361724 290669 362834 64520 287768 117535 299620 64627 295270 690795 84486 304832 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%10230408 Tandem pore domain potassium channels 116489 59324 445371 65272 116491 64120 84429 688996 170899 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-RNO-166665.1 Terminal pathway of complement 24237 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%10228940 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 25268 29243 260320 25295 306608 24946 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%10230308 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 89821 294048 308501 300955 25262 25155 100913063 25679 25513 499356 367901 81678 81504 366508 313845 100360919 29337 84357 361618 116689 362046 LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism 300723 298942 171151 296925 291450 361272 364975 117024 29416 100169747 299201 303272 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%10230918 Degradation of GLI1 by the proteasome 117262 85492 287984 65138 311567 94198 29673 50522 29671 29670 361769 29677 29676 29675 192255 140589 81827 287280 83806 311078 361765 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%10228694 Post NMDA receptor activation events 501560 171503 24244 117269 83506 25521 25050 25725 29699 60341 81771 293508 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-RNO-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 29718 294962 83579 81657 680149 25743 170847 58979 64199 114117 116649 24400 79218 50599 81667 83633 245986 116560 29713 60449 29712 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%10230948 Trafficking of myristoylated proteins to the cilium 363126 64664 367714 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%10229622 Cell-Cell communication 83427 63879 81504 83501 25528 25066 25150 292064 25507 313806 100361294 362850 300955 316639 313474 50646 363509 25125 360652 301334 304297 84353 81679 311163 300289 25751 362279 314641 50654 83502 25697 310695 315546 64563 100359836 691517 266758 363875 362973 81634 170922 362332 60371 362650 57341 293860 293142 29460 84430 24511 688673 25705 81717 500569 689820 287772 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 29425 64156 100360846 116479 54281 24790 83712 307237 117263 81918 25581 29666 81650 24514 303353 365388 29364 302783 117262 85492 192275 24829 306945 287984 24828 65138 155183 313048 94198 29673 50522 305679 84006 100188932 29671 361866 29670 117056 29677 680498 29676 29675 685909 680615 316369 192255 365877 686092 308417 64315 81827 304109 25724 361537 64465 116549 26955 498515 83806 310174 311078 192248 360820 117048 313648 192183 303175 360687 498281 688041 301887 29181 100912032 84407 497229 24498 81736 303068 300445 361432 363058 29144 25409 64701 64627 29606 500870 78947 690795 499537 29163 29162 293721 360882 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10230564 Activated NOTCH1 Transmits Signal to the Nucleus 50522 64156 192255 100912032 304591 311567 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs 29376 24605 293621 287942 81504 24525 25150 313845 29613 315992 25738 363875 140670 56011 25513 85243 117273 83805 25507 81737 59109 310738 25054 54281 25730 24225 85385 116548 315648 81771 117269 501099 58960 170911 114486 50689 289014 363193 24673 315994 315305 116478 314612 501560 116563 24672 116743 300980 117281 116590 170851 314850 29622 65046 117535 25467 295347 314910 114090 116663 300078 60587 54245 83800 54241 SIGNALING BY FGFR2%REACTOME%R-RNO-5654738.1 Signaling by FGFR2 689116 298075 289561 292778 24605 500409 293621 362950 307810 361655 81504 83503 24525 117017 498109 313845 363633 25738 29578 500985 64200 66017 25622 25444 29349 54250 25513 25317 29369 25022 83805 29368 170700 116499 60662 60464 170583 64156 85385 170911 25443 29348 361388 170579 170633 500526 64535 499349 114486 50522 50689 24673 192255 306141 24672 140931 117281 116590 100912032 316213 314850 29497 288588 316123 690966 361365 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME%R-RNO-8932506.1 DAG1 core M1 glycosylations 362567 84430 688673 114489 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%10230106 Interleukin-20 family signaling 304091 362629 25622 362628 25125 25126 681112 500836 170819 444986 685840 100911249 24918 100361294 25326 24514 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME%R-RNO-428643.1 Organic anion transport by SLC5 17 25 transporters 29743 362188 363103 64201 170943 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-RNO-964739.1 N-glycan trimming and elongation in the cis-Golgi 362625 295319 81519 140808 REGULATION OF TP53 DEGRADATION%REACTOME%R-RNO-6804757.1 Regulation of TP53 Degradation 25405 54237 115771 114212 296648 25233 360471 81745 24185 282844 50522 315189 310131 24673 300711 282845 192255 24672 24842 295052 117281 64226 100912032 311575 304798 114494 29414 64156 56718 315648 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 97%10228954 Synthesis of glycosylphosphatidylinositol (GPI) 29640 288041 315807 79112 366478 287159 100910143 362756 364032 192263 378774 VEGFA-VEGFR2 PATHWAY%REACTOME%R-RNO-4420097.1 VEGFA-VEGFR2 Pathway 24605 293621 25233 24185 81745 24525 25614 25150 295378 25738 29431 29432 363875 246273 361992 293508 170897 25522 25513 85243 117273 83805 24244 170538 24680 25023 300955 679934 170911 296648 25589 50646 25676 286928 117542 29302 29433 60352 362513 289014 296456 315189 310131 79249 310688 84353 83785 79129 315994 66021 316369 294568 315348 314612 81679 308666 64465 362271 311163 313024 24600 25414 25537 360820 58823 682937 64226 29414 56718 54245 299331 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229926 Free fatty acids regulate insulin secretion 24654 85240 114024 113976 81666 266607 81662 METALLOPROTEASE DUBS%REACTOME%R-RNO-5689901.1 Metalloprotease DUBs 316794 502125 362704 171565 311078 24828 100912032 497672 301164 64557 50522 498798 287362 64156 289468 680615 290997 192255 290631 64646 365877 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-RNO-5684264.1 MAP3K8 (TPL2)-dependent MAPK1 3 activation 50522 116596 84351 287280 309361 64156 303024 361765 192255 100912032 309295 81736 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-RNO-1296067.1 Potassium transport channels 29718 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 97%10230716 SUMO is conjugated to E1 (UBA2:SAE1) 308384 301442 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 97%10228530 Homology Directed Repair 316794 171366 299112 316235 171525 85482 298098 288003 289777 287634 362385 116468 192218 290805 304573 25737 293489 298534 288414 287927 685055 310034 297561 305000 25573 308755 361815 306734 499417 300711 299638 302982 690043 288079 297627 290027 59294 311860 84490 296099 25591 295052 360588 497856 302953 64012 499870 294800 293678 498265 114494 498411 308669 64156 291787 116725 289468 100361529 689055 297486 361698 140583 362827 84495 362704 24829 306945 50522 192255 303175 100912032 497672 293452 64557 304719 64627 83508 363924 289758 102551085 303194 315969 498119 89809 499966 290997 59102 64046 290631 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME%R-RNO-177504.1 Retrograde neurotrophin signalling 65046 116563 300078 59109 116743 310738 140670 83800 54241 FATTY ACID METABOLISM%REACTOME%R-RNO-8978868.1 Fatty acid metabolism 25682 307096 24886 25527 25526 59103 29224 58962 94199 361266 364773 310848 498790 293453 362809 498789 50671 171516 291984 246074 171410 171402 171400 170465 191574 687008 170570 116568 54398 364134 287454 100363074 29527 29328 29470 81639 29277 114097 191576 299732 24296 404280 24297 291939 65030 25290 363516 25756 25757 140547 307170 359725 361802 65183 29566 266604 311849 60581 24307 290623 117543 266674 287424 287425 502969 24404 298423 286904 313375 24306 299566 503122 301120 50549 315973 289125 114024 113976 83842 83522 361895 498728 84575 26759 117243 300783 619561 25426 25413 100911581 680115 84013 83512 117182 84024 24565 312086 296851 361992 25288 25045 25287 113965 171155 170670 29411 309449 29510 24159 29726 94340 25363 679520 64562 24158 64304 29624 289014 308518 25541 291075 503049 85255 79244 50559 65192 50681 373545 114209 113956 85239 84029 64461 314304 501072 291283 171142 303577 307092 ARACHIDONATE METABOLISM%REACTOME%R-RNO-2142753.1 Arachidonate metabolism 307096 24886 25527 25526 59103 29224 58962 25426 100911581 361266 94199 364773 84024 24565 498790 310848 312086 296851 362809 498789 171516 291984 191574 116568 679520 287454 29527 29328 81639 29277 114097 299732 24296 24297 65030 29624 25290 289014 29566 266604 24307 290623 266674 287424 287425 502969 24404 298423 286904 313375 24306 299566 503122 50549 291283 307092 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 97%10230780 HSP90 chaperone cycle for SHRs 300721 29564 361810 299850 24472 192277 252902 294010 29489 84428 301252 362809 260321 25154 24963 24413 299121 60460 65028 29167 140734 81655 24468 58945 299331 24208 25672 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%10231674 Mitochondrial unfolded protein response (UPRmt) 293615 24890 24472 65028 79245 24185 294515 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-RNO-8957275.1 Post-translational protein phosphorylation 503164 24765 56646 689404 25376 94168 362862 361676 60333 83501 29417 691517 367252 84491 25087 25506 24367 25373 79224 25268 25081 304917 170583 25649 25728 24648 25353 140638 24232 24825 116640 116510 63880 29650 116635 171154 79210 24186 362859 683007 361029 59107 296290 25615 292485 24233 24259 25307 406161 29461 83476 308807 288038 303635 289525 25434 24498 192152 300445 63878 680692 313954 25236 25277 298296 24484 84595 304334 54226 360622 363455 338474 25685 362182 83727 54225 286906 315111 298683 79110 89842 25285 303743 29237 292905 29160 114122 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 97%10230702 FCERI mediated Ca+2 mobilization 361400 100361818 84492 305311 24674 24675 25155 367901 81515 81504 24244 295378 81511 313845 100360919 25738 29337 366962 85385 363577 29748 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855229.1 IP6 and IP7 transport between cytosol and nucleus 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 294429 499974 MET RECEPTOR ACTIVATION%REACTOME%R-RNO-6806942.1 MET Receptor Activation 292770 29135 24553 24446 311331 CARBOHYDRATE METABOLISM%REACTOME%R-RNO-71387.1 Carbohydrate metabolism 297522 299825 407765 81919 58924 678739 29353 361377 140671 404783 367562 64035 300993 314140 81675 367166 307091 24434 100301568 81651 266805 362029 501157 114122 50568 25181 363513 298003 366064 298690 362706 100360180 25694 315939 690987 361378 310864 64152 296564 171408 294103 295443 29562 690945 287479 304885 282821 288161 500052 64524 84597 313843 306866 24689 316067 290277 362383 309513 246136 83688 25227 24782 363103 25216 246232 78959 24778 24244 294449 688293 293451 64537 295430 360630 84406 364476 108349781 303218 302489 292155 29633 363618 114002 368128 684979 24377 299907 691984 171517 291577 116673 291770 24771 297554 500257 295934 300757 304322 302302 317322 291015 25236 301525 286974 365583 303923 316583 297865 58920 305571 314694 25592 316533 84400 362275 361450 84468 363040 64442 64445 293667 367145 307859 294673 314771 316033 292073 64507 313536 500961 494342 362924 81682 58968 114508 65196 25741 24651 362282 25697 24334 25104 316265 315722 292804 25060 292138 24189 296973 289608 54283 25634 25438 685076 24385 66020 116721 303565 100364027 24638 24192 24959 361730 294321 684314 60416 24188 498731 24788 25659 24191 24849 25059 24640 24642 24644 25658 29573 117276 24362 65152 25393 294429 287830 291874 362281 113975 292085 360670 117267 25406 295692 117021 362335 366016 58958 29139 362557 65274 113929 245922 81738 683983 53372 290638 25497 499974 25615 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%10229714 Integrin signaling 25414 24366 24367 25155 685269 81745 24185 29434 59326 171337 81504 83805 361714 29302 295347 25614 313845 54245 85385 24697 315707 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 97%10228996 Insulin effects increased synthesis of Xylulose-5-Phosphate 83688 64524 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%10230094 Synthesis of GDP-mannose 300089 302915 300741 501167 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling 298947 497931 170911 296648 25233 497932 81745 24185 25660 25408 25150 366508 315189 310131 246273 361992 116596 64226 25513 85243 313050 29414 56822 56718 60664 360640 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%10229868 Striated Muscle Contraction 81818 64362 24838 24837 24907 24585 296369 171409 290561 56781 24851 295261 500450 363925 171009 29389 24852 29248 24583 29388 295929 58814 300838 M PHASE%REACTOME DATABASE ID RELEASE 97%10228872 M Phase 363059 311802 306599 366403 29564 65158 308870 81740 192228 25573 297522 29479 363055 301442 305467 498266 294010 29214 500069 692032 307947 290626 305882 309098 315423 171566 367153 315508 300149 314787 683722 361916 360672 308064 100362495 362980 498265 311573 293844 313861 310344 311529 362203 307169 287929 246150 300963 60336 308663 252921 64462 680991 60347 307347 365191 309179 299147 312754 29167 140734 361831 58945 282834 315740 366381 292588 293155 296368 361389 288671 290875 305420 360643 689820 361308 363720 64528 64156 315648 246772 64193 24708 292263 50522 50689 363193 252902 24673 362548 192255 24672 290668 117281 116590 100912032 85252 299331 364419 29753 83572 679886 24680 290577 304218 313304 25203 63996 316737 54237 684771 25023 305343 287447 25437 25515 114087 299204 94266 29648 116685 363174 64515 681185 297176 298594 114592 170845 305392 680089 308443 362519 303037 306464 362438 679342 296137 291441 24669 257649 257644 64041 287598 317252 307805 311191 114764 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 83836 295661 363198 304951 682908 64158 684439 500377 289150 117104 361416 304477 307833 246118 500363 300218 498736 65201 316531 307351 291081 84509 313478 679312 296554 29213 362700 500929 287772 292766 29669 29668 56010 29425 58822 100360846 117263 25581 29666 81650 303353 294429 365388 287830 291874 363481 362281 302783 117262 113975 85492 292085 295692 24829 117021 362335 306945 287984 287624 24828 65138 366016 58958 317425 94198 287873 29673 362557 65274 29671 299850 113929 29670 81754 29677 29676 245922 29489 81738 29675 685909 683983 680615 53372 25497 365877 499974 81827 116549 83806 311078 303175 64627 690795 81655 24917 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 97%10229736 Ligand-independent caspase activation via DCC 25311 58918 25402 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%10230882 Release of Hh-Np from the secreting cell 311324 499241 84399 29499 84380 303743 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%10230300 Growth hormone receptor signaling 50689 24683 89817 24918 25235 24697 24684 24391 116590 81515 24514 25126 PHENYLALANINE METABOLISM%REACTOME%R-RNO-8964208.1 Phenylalanine metabolism 29700 100360621 246307 311844 64192 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%10231530 Regulation of FOXO transcriptional activity by acetylation 293615 84482 294515 301164 309757 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 97%10231564 Signaling by CSF3 (G-CSF) 89829 25622 64624 25155 81807 81515 100912032 81504 24525 641452 81920 50522 64525 84477 25734 64156 361831 85385 100361294 24514 192255 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors 116563 84591 60355 25023 140670 50592 29629 29628 84016 29627 65046 363447 171571 24681 24680 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 97%10228516 Synthesis of PA 305166 296130 29653 681694 296048 311341 288322 25097 287366 25062 361467 25096 362039 691905 680971 294324 29354 290843 296623 29692 295631 84470 298579 29526 29359 60666 362702 170919 362058 363159 311821 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME DATABASE ID RELEASE 97%10231662 TGFBR3 regulates TGF-beta signaling 29591 59086 25388 81809 83823 25387 29610 81810 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 97%10229694 Biosynthesis of specialized proresolving mediators (SPMs) 287454 29527 29328 79242 81639 29277 114097 25086 171522 299732 24296 24297 499689 65030 29624 25290 266682 252931 PORPHYRIN METABOLISM%REACTOME%R-RNO-189445.1 Porphyrin metabolism 25303 25748 65155 25374 289219 304024 691853 309391 309070 361338 24861 494500 24360 116599 24451 79239 292737 58978 312382 140860 24565 24186 REGULATION OF APOPTOSIS%REACTOME%R-RNO-169911.1 Regulation of Apoptosis 298282 171116 HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230618 Hyaluronan degradation 300757 363103 24782 25406 64152 404783 500052 300993 367166 24434 294673 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-RNO-2980767.1 Activation of NIMA Kinases NEK9, NEK6, NEK7 25203 54237 25515 299204 DNA REPAIR%REACTOME DATABASE ID RELEASE 97%10228224 DNA Repair 83614 316794 690244 498749 171366 171525 303193 85482 291905 289777 287634 192218 360915 114212 290805 361767 497967 293489 298534 287927 685055 310034 297561 25573 313539 308755 361815 306734 301442 499417 301128 300711 299638 300795 302982 309256 690043 302502 312641 292127 288079 297627 100360594 65179 313387 292172 360847 59294 100147704 311860 310745 296099 295052 360748 360588 497856 302953 64012 499870 294800 293678 498265 368002 314380 29722 114494 498411 308669 100359714 293719 291787 246216 289468 259171 361181 100361529 689055 287367 25019 297486 361698 140583 366163 362827 84495 362704 306257 245976 362678 691105 300772 499155 502320 303742 314172 361381 362394 501552 288588 266713 502227 690966 361365 84389 289561 292778 288651 361580 294693 83503 117017 291703 498109 363633 290232 297758 500054 307798 307861 289508 64156 116725 314061 361925 362479 360471 306274 50522 292101 84478 140639 192255 313098 261736 116554 295704 100912032 117039 59102 24919 299112 298098 362385 304573 363164 307905 367090 305957 298012 293494 65137 316440 362258 291737 315523 296084 85423 298693 81816 289758 316344 100362121 310707 89809 313702 309812 316235 81685 288003 116468 81709 25737 288414 305000 362600 290027 84490 25591 79116 29240 83507 287772 292766 29669 29668 300813 29425 100360846 117263 25581 29666 303353 365388 302783 117262 85492 362412 24829 306945 287984 24828 65138 94198 29673 363273 29671 29670 29677 29676 29675 116643 685909 287876 680615 365877 81827 363283 24842 83806 311078 303175 289757 170841 363251 680915 497672 315344 81528 293452 64557 156826 304719 64627 83508 363924 690795 102551085 303194 315969 290907 363247 498119 499966 290997 64046 290631 502935 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%10231638 Ciprofloxacin ADME 24904 312382 170698 24186 METHYLATION%REACTOME%R-RNO-156581.1 Methylation 683630 290947 140925 81522 25331 690050 24297 171347 29443 24267 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%10230578 Collagen biosynthesis and modifying enzymes 367313 678743 499431 84352 363158 290637 84032 363458 288583 306628 290905 301012 85490 315071 25506 287899 29569 353303 314981 312115 289081 60379 25681 685612 29345 304021 305253 83470 288016 365460 64367 294279 25412 25654 362584 315979 114200 362285 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231616 Regulation of CDH11 gene transcription 24790 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%10229546 WNT mediated activation of DVL 116549 58822 309419 83721 81650 303811 303251 TP53 REGULATES METABOLIC GENES%REACTOME%R-RNO-5628897.1 TP53 Regulates Metabolic Genes 117254 25578 25233 140942 24185 60445 29753 292804 502988 116484 25309 29338 26195 171335 25576 56011 654441 25577 303393 313017 65248 26198 84683 56010 315427 94194 688386 681024 64562 100188937 24855 54322 360229 502894 25282 29445 24377 25520 83803 308869 310091 298514 24398 64226 295357 373545 297960 102555170 26954 690675 117044 117043 29414 252934 113898 362045 56718 192268 360776 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 97%10230746 Postmitotic nuclear pore complex (NPC) reformation 287830 291874 113975 682908 292085 295692 117021 362335 366016 84509 25573 362557 297522 301442 81738 683983 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%10228580 RNA Polymerase II Transcription Termination 689116 171365 681062 680737 311166 298075 311670 299256 687711 116697 366468 501688 299811 289582 683927 304277 100362099 291877 681031 365407 314417 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 97%10230362 Cross-presentation of particulate exogenous antigens (phagosomes) 296456 79129 66021 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 97%10229134 Signaling by TGF-beta Receptor Complex 29417 500985 362110 25490 25591 287155 24511 25522 297893 117273 300813 304758 100360427 64156 114208 116479 54281 24790 499929 363445 81918 25631 500715 24666 680111 361178 29357 29610 84396 311061 29302 50522 50689 296456 59086 310655 81809 192255 297699 313477 81810 292734 25717 29591 362800 59107 50554 25639 59106 83837 83838 81516 116590 100912032 690516 81920 313757 361831 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-RNO-211163.1 AKT-mediated inactivation of FOXO1A 84482 29414 25233 24185 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 97%10229970 Regulation of actin dynamics for phagocytic cup formation 81732 117538 295279 297518 289211 259242 300955 310178 679934 25155 65261 367901 286928 25017 81504 117542 25614 295378 50689 100360919 360854 29431 79249 363875 287876 301252 288669 294568 289820 315348 308666 64465 362271 311860 313024 58823 81822 682937 81824 54227 116590 300678 54245 299331 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%10231648 MITF-M-regulated melanocyte development 361604 690660 116483 306804 117516 287191 290868 29361 25017 25573 50689 292028 170577 50645 360034 301442 84353 291624 312451 60427 84027 116590 297893 309757 288480 29414 85252 353305 64030 25094 161452 289352 81771 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 97%10228674 Transport of the SLBP independent Mature mRNA 287830 291874 362281 689116 113975 298075 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 59087 499974 690585 117045 294429 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-RNO-373076.1 Class A 1 (Rhodopsin-like receptors) 81645 287730 24816 24938 25107 25229 688605 689936 316019 29385 246075 379044 282832 25340 50672 25342 29141 292409 64042 53949 308408 25477 246759 29397 24260 25593 25111 292419 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25329 25449 29363 54258 500157 84348 24232 81752 24473 305236 50577 289023 171551 65032 24925 24806 24808 24929 290493 292794 117549 316259 295144 192223 317219 25570 81503 29256 498289 362505 100360071 497196 100911796 497078 25542 64636 302619 299242 117264 57305 353250 308163 84007 117027 57302 89810 360579 29581 171056 365228 306307 25555 29238 89808 81644 29595 29237 25108 192205 29235 192206 29597 29234 84475 29471 171044 24318 102552838 360918 294123 116700 314386 24797 294124 685243 24677 25524 25645 294121 25083 114098 114099 25087 84023 294807 25653 25652 24323 24326 24448 81668 29335 301086 690158 367315 24659 266997 24772 114105 60628 25504 445269 309212 24221 25187 78964 171371 494319 497942 498475 192648 192649 246358 29316 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 310444 25075 25195 192646 310327 501177 301066 25726 25605 113914 679957 287910 298006 25723 171158 362454 498335 117041 25616 366270 366274 29538 117029 54226 245920 83518 24889 266607 60669 60665 29413 29412 78976 25298 679975 54305 85268 302378 25706 170926 24179 259224 259222 24613 25380 25264 24174 24175 24180 25265 363682 29180 288995 378939 691774 116677 319107 64803 319105 24182 25033 29191 287673 499194 113959 24717 25601 25245 25369 63843 25248 170704 117518 25007 260319 60337 25360 58812 287561 287562 24604 63850 171104 171108 83567 310869 29290 171101 58949 29636 116498 24807 66025 306792 298062 60399 310812 116744 29415 29733 500317 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231450 Biosynthesis of DPAn-3-derived protectins and resolvins 81639 25290 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 97%10231040 MAP2K and MAPK activation 58960 24605 293621 114486 29302 24525 305679 50689 170577 25388 288924 59322 29542 498576 64363 24366 24367 685269 56011 116590 170851 25387 171337 83805 295347 362045 24703 315707 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 97%10229668 Synthesis of PC 286936 116549 316737 295417 294255 310773 29367 25511 29194 298504 29510 85254 296128 361467 81650 140544 363024 ION CHANNEL TRANSPORT%REACTOME%R-RNO-983712.1 Ion channel transport 25749 293735 304315 292168 286920 689103 297930 63866 294141 314401 312981 312896 83514 295041 497948 361586 192675 58950 24245 29465 299714 24246 171497 364973 679906 499287 66026 362053 59299 689991 29233 171140 29232 79123 362247 314847 308015 294329 293874 315272 63882 266730 24244 116469 114246 25688 689560 79430 83810 25122 25364 140933 301111 292597 246215 311287 24768 24767 79425 89821 308637 171143 367318 171384 24941 116601 25400 25391 64672 24211 29693 24212 24213 29600 63847 29599 63848 29598 60395 58971 297932 64190 298103 116831 29639 29132 29757 289407 362802 368044 296981 298451 299971 83615 170667 436582 297566 312488 117596 94170 116664 366545 64156 24703 288026 361929 291411 291555 25650 311396 24217 365266 303056 306600 25390 171496 360932 303856 290673 362645 50522 192255 100912032 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling 64373 306400 316009 361568 25537 24553 363875 78966 117273 306790 362993 INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling 25670 313845 690369 85385 24918 25746 25125 25326 25126 81504 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%10228350 tRNA Aminoacylation 310856 LACTOSE SYNTHESIS%REACTOME%R-RNO-5653890.1 Lactose synthesis 24778 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-RNO-5626978.1 TNFR1-mediated ceramide production 94338 83427 25625 24835 83537 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-RNO-111471.1 Apoptotic factor-mediated response 64026 78963 295961 58918 100360940 63879 287606 116590 353316 690675 50689 25402 116502 25309 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-RNO-174403.1 Glutathione synthesis and recycling 156275 362196 25458 360994 29566 25283 408206 29739 116568 291394 116684 GLUTATHIONE CONJUGATION%REACTOME%R-RNO-156590.1 Glutathione conjugation 681913 291394 499689 116684 58962 156275 24421 24423 24422 24424 360994 29566 24426 29739 78959 297029 171341 290401 81869 494499 25283 29487 494500 362196 25458 501110 309465 64352 408206 116568 295037 25260 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation 315093 50557 63879 25233 24185 291171 500572 310306 79209 294924 287155 287772 292766 297893 291999 29669 29668 296988 29425 64156 100360846 83712 117263 25581 29666 81650 303353 365388 117262 85492 287984 360471 65138 313048 94198 29673 50522 29671 29670 29677 29676 29675 25489 307151 313038 192255 309626 310258 81827 303730 315136 116549 100362346 83806 311078 308051 308869 310091 298514 501403 310614 64226 295357 361724 290669 688041 362834 100912032 64520 297960 26954 117535 117044 117043 29414 362045 56718 360776 686412 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-RNO-390471.1 Association of TriC CCT with target proteins during biosynthesis 295230 29374 170897 297406 299809 24818 363658 288305 294864 DRUG ADME%REACTOME DATABASE ID RELEASE 97%10228908 Drug ADME 353307 307096 60423 63997 140944 291394 63867 156275 295378 24421 24422 24172 361266 24426 360268 363875 361510 58978 312382 140860 266682 364773 83782 84024 24565 116721 498790 312086 191575 170924 361637 252931 25303 24912 498789 494499 116632 116631 300981 171516 266685 24861 113902 501907 494500 65194 24904 286954 29504 29503 501110 113992 140668 690050 290029 408206 25027 24165 191574 116568 24465 25260 25368 24902 25246 29277 25086 688536 83783 299270 498940 25116 293779 290681 25117 286989 29566 353317 170698 246263 24186 89776 171522 301005 295088 311422 100363253 362329 497811 291283 307092 TRP CHANNELS%REACTOME DATABASE ID RELEASE 97%10230770 TRP channels 679906 89821 66026 171143 171384 362247 294329 293874 292168 116469 114246 60395 312896 83810 497948 361586 140933 29465 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229388 Pregnenolone biosynthesis 24192 79122 29189 313786 291699 25557 24230 29680 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 97%10229274 APC-Cdc20 mediated degradation of Nek2A 64515 297176 100912032 366381 50522 292588 293155 296368 361389 64156 288671 290875 361831 305420 360643 192255 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-RNO-2467813.1 Separation of Sister Chromatids 363059 29564 297522 83572 290577 304218 313304 63996 684771 305343 25515 94266 309179 299147 312754 29648 363174 64515 681185 297176 298594 114592 170845 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 307805 311191 361831 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 83836 295661 363198 304951 684439 289150 361416 304477 65201 366381 292588 293155 296368 361389 288671 290875 305420 360643 287772 292766 29669 29668 29425 64156 100360846 117263 25581 29666 315648 303353 294429 365388 287830 363481 117262 85492 64193 292085 287984 287624 65138 94198 29673 50522 29671 29670 252902 29677 363193 29676 29675 29489 81738 24673 362548 683983 192255 81827 24672 83806 311078 117281 100912032 85252 81655 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%10231776 GBP-mediated host defense 64511 171164 81746 25318 304266 54281 24649 81822 287876 362050 313017 S PHASE%REACTOME%R-RNO-69242.1 S Phase 313138 313479 299112 298098 292071 362385 312538 291927 360621 304573 24185 362304 301430 85241 499655 59294 366275 295052 171102 308937 83571 114494 361698 290577 304218 313304 680014 63996 684771 691979 305343 289758 266713 361831 89809 292058 307639 499914 290842 84389 288003 116468 25233 25737 288414 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 84490 287772 292766 94201 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 58919 117262 85492 24708 294790 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 171103 100912032 307585 29414 301323 288532 316273 59102 295596 296178 29728 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10231246 Lipid particle organization 291541 500292 311617 305150 290223 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation 362809 260321 24963 292887 286899 171140 25400 60460 64226 25420 24472 56718 24468 299331 79245 301252 24245 24246 113906 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%10229528 MDK and PTN in ALK signaling 25613 24924 81517 266802 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%10228930 Conjugation of salicylate with glycine 293779 353317 246263 688536 361637 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 97%10229864 Beta-oxidation of very long chain fatty acids 85239 65192 64461 50681 291075 501072 171142 79244 363516 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230866 Glycosphingolipid transport 500132 64310 299488 363120 293485 29579 288707 313771 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events 117269 24410 83613 25400 64053 25252 171503 83506 58948 191573 117284 24409 24245 24246 293508 501560 24408 29495 25521 171140 25725 50592 29629 29628 29627 24412 24244 24411 25050 29699 60341 81771 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856828.1 Clathrin-mediated endocytosis 116717 81645 297518 59325 360915 60568 311854 60566 81504 303251 60564 24180 29216 500985 25238 288669 363466 64558 56084 25490 114590 25372 85256 85491 298598 290639 292944 287367 266606 314349 81922 313474 498798 360854 171574 29183 192154 25716 310097 116561 81921 116563 64678 116743 89816 311030 81824 83730 25387 313409 192152 64022 288779 25751 312694 81659 24468 287709 361632 54225 83800 54241 25151 25108 683687 314641 29704 25388 360202 312689 24255 300438 64633 140670 246310 117028 25433 300678 25313 64156 25710 84357 24932 24221 140694 81732 85238 310839 24825 24329 24827 117106 84018 50522 363273 363266 192255 289820 79121 24805 261736 79128 24807 363283 29528 192348 361244 361120 29491 100912032 65046 311880 60668 117277 313934 60422 117039 65178 317396 24803 124461 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%10230240 O-linked glycosylation 362924 65196 310207 25197 140568 66015 316091 291212 306549 287899 84430 688673 65044 313139 292325 102550196 313233 305253 83627 362567 308440 361368 311202 102554393 299314 362520 315728 299841 361142 493574 499968 257647 474348 114489 497227 308390 291958 306664 64043 367384 286971 307838 500152 286976 304135 315263 29750 313878 362760 497619 445442 171569 304571 297757 64456 500032 314655 685758 170501 294809 364630 362539 309114 308787 361886 100360475 293004 292406 303692 288611 120100673 310670 100361647 361412 116740 312566 290638 690914 315879 311952 29758 311039 361332 300474 302499 300475 366061 316583 305571 79214 362275 363040 64442 64445 293667 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-RNO-181431.1 Acetylcholine binding and downstream events 25590 29422 25103 81721 54239 25753 170945 54240 171131 65024 25302 79557 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 97%10228386 Pyrimidine salvage 315219 311864 362638 291824 79127 291585 289801 304944 295620 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 97%10230456 Acyl chain remodeling of DAG and TAG 302425 678749 84497 29254 252900 361676 362972 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-RNO-8939236.1 RUNX1 regulates transcription of genes involved in differentiation of HSCs 117262 85492 287984 65138 311567 94198 29673 50522 29671 29670 29677 29676 362675 29675 192255 363014 25720 81827 25172 311860 83806 313507 311078 25159 171046 287772 292766 100912032 29669 29668 85471 50662 361391 29425 64156 100360846 266713 117263 25581 29666 315606 303353 365388 84389 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-RNO-9851695.1 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 302783 290939 299905 679693 24708 24829 306945 24828 84578 117056 85265 680498 83724 685909 680615 497991 25664 619436 365877 83516 291567 311860 300367 365755 302711 303175 306030 309757 140908 64627 299607 287475 303403 497941 690795 299180 317343 316209 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%10228922 Metabolism of steroids 307096 25573 29216 361266 499417 364773 498790 498789 171516 25329 191574 114700 362827 25279 64677 25270 24873 289456 116463 691018 25322 296972 79243 301024 24950 259221 291699 24230 25557 116700 25429 84509 301517 25428 79122 25427 29189 84013 313786 83724 58978 362782 60351 117182 29680 24192 305291 291211 293688 25675 140668 29637 63865 619549 81726 298298 81727 29540 29230 308100 309262 310645 117278 114100 83791 81681 64191 78968 300095 140910 29580 89784 24470 682974 29632 29725 362360 299270 298369 25146 25116 502348 24777 360348 25117 296461 24800 79111 25440 311129 25541 246211 303497 303879 170698 83569 79244 24186 309527 300790 65192 192242 80848 291283 24917 89842 307092 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228414 Ligand-dependent caspase activation 448830 60350 29260 266610 306886 64044 246097 117279 25385 363328 246756 364867 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 97%10231580 Inactivation of CSF3 (G-CSF) signaling 89829 64624 25155 81807 81515 100912032 641452 81920 50522 64525 25734 64156 361831 100361294 24514 192255 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 97%10228566 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 25363 171155 170670 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 97%10229886 Chaperonin-mediated protein folding 294962 295230 116549 29374 170897 297406 299809 83579 64013 363658 54296 24400 81667 81650 24818 60449 288305 29481 294864 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 97%10231274 MET activates PTPN11 24553 25622 361388 24446 81504 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-RNO-196780.1 Biotin transport and metabolism 294972 170551 288240 306262 361884 687008 60581 25104 PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 66017 25444 25622 170911 29349 54250 361388 25513 25317 29369 81504 314850 29368 170700 116499 60464 170583 289625 25114 170582 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%10230332 Downstream signaling events of B Cell Receptor (BCR) 100361818 361400 24605 24674 293621 24675 24525 307366 287772 29434 292766 29669 24244 29668 29425 64156 100360846 117263 25581 29666 303353 309295 365388 117262 85492 25023 287984 65138 94198 29673 50522 29671 84351 29670 29677 29676 29675 192255 316241 81827 287280 25639 83806 311078 361765 305584 100912032 81736 25493 309361 303024 29748 83477 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 97%10231542 Transcriptional Regulation by NPAS4 266734 29657 25242 84469 25243 SIGNALING BY NTRK2 (TRKB)%REACTOME%R-RNO-9006115.1 Signaling by NTRK2 (TRKB) 25150 313845 25738 315992 25054 25730 24225 363875 81504 314850 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-RNO-388841.1 Costimulation by the CD28 family 407756 81745 24185 25660 81504 25408 25150 25622 25513 85243 60664 116689 170911 296648 309179 299147 366508 312754 315189 310131 25233 29431 29432 366962 363875 246273 361992 289874 287772 292766 81515 94201 83805 290783 65248 294269 29669 29668 300678 362040 313050 56010 25300 29425 24981 64156 100360846 25710 116967 24986 24932 83712 117263 25581 29666 315707 315648 81650 315606 303353 365388 290829 58919 290823 302783 117262 85492 298947 192275 407784 64545 64562 497931 24829 499415 497932 306945 287984 24828 65138 362093 313048 94198 29673 29433 50522 100188932 29671 29670 117056 29677 363193 680498 29676 29675 24673 116643 685909 680615 309304 192255 290638 365877 686092 301626 116596 81827 25520 24672 64465 116549 83803 287280 83806 311078 84027 313648 117281 361765 362891 303175 64226 373545 688041 363160 100912032 301555 499342 287643 64701 56822 29414 64627 690315 690795 56718 360967 304794 360640 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-RNO-209776.1 Metabolism of amine-derived hormones 25699 311374 24848 266807 25120 24311 317675 79107 246281 116700 114613 65162 308129 29475 25430 25085 302899 24661 25653 XENOBIOTICS%REACTOME DATABASE ID RELEASE 97%10228540 Xenobiotics 24894 24299 502969 24895 288517 29277 313375 25086 171522 24296 24297 54246 499353 25242 25243 266682 308445 252931 498999 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 140583 310258 60661 688041 499874 313048 287662 313978 297093 309457 83712 307151 300320 100362678 361178 309626 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10228794 Extracellular matrix organization 290257 25216 313785 24907 25335 306628 290905 309684 25361 85490 315071 24914 25506 287899 29569 353303 554172 314981 312115 289081 60379 25681 29345 304021 305253 83470 288016 365460 64367 290350 309380 294279 114489 25412 25654 315714 24680 362584 315979 114200 362285 367313 302248 678743 84352 363158 290637 84032 363458 288583 29302 296456 59086 301012 81809 81613 292734 25717 362800 59107 303468 59106 310683 432360 83838 362715 25118 29158 500364 305941 116673 24771 679837 497892 25600 25043 85272 29373 298936 500245 313662 307548 64350 25592 25304 66027 252835 293677 83577 299940 114122 81682 58968 50654 83502 25697 29175 309816 691517 25627 65164 315174 66015 65205 170808 24511 24291 83513 24366 116694 24367 57025 54250 24691 685269 29268 29543 306260 685612 117061 85253 499285 304608 304802 63834 315388 116479 54281 29156 29155 29154 29153 25393 25353 303000 299606 29364 683849 499271 291848 360606 24617 311061 304135 499431 25567 300338 29331 81008 25246 170921 81707 116640 445442 25403 25406 25481 29583 24153 103690254 116510 100169747 81687 306404 300341 408218 29139 117033 81686 362347 63849 29650 25052 83685 308476 362701 25724 54266 25615 308995 298702 315509 303068 25713 83727 360647 619374 25464 CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%10229230 Chylomicron clearance 300438 25728 54225 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%10229250 Downstream signaling of activated FGFR4 24605 293621 170911 361388 81504 24525 313845 25738 66017 25444 25622 29349 54250 25513 25317 29369 316213 29368 314850 170700 116499 60464 170583 289625 25114 170582 85385 IRON UPTAKE AND TRANSPORT%REACTOME%R-RNO-917937.1 Iron uptake and transport 117152 29292 170840 24825 170824 117240 170496 25715 50522 303333 297932 298103 50655 312382 192255 29757 289407 25490 362802 368044 64678 296981 287280 298451 299971 83615 170667 436582 297566 312488 100912032 117596 94170 116664 25319 366545 24451 79239 64156 499991 29199 288562 64831 291470 295669 305886 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-RNO-427589.1 Type II Na+ Pi cotransporters 246234 25548 84395 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-RNO-165181.1 Inhibition of TSC complex formation by AKT (PKB) 29414 25233 24855 24185 60445 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375280.1 Amine ligand-binding receptors 81645 85268 24473 24318 65032 294123 24925 294124 25229 24174 24175 25075 25645 25195 294121 25083 113914 319107 319105 53949 24448 302619 24260 25111 170704 25323 25324 29581 25187 29238 25689 494319 29595 29413 29412 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 97%10229356 Oligomerization of connexins into connexons 29584 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-RNO-425397.1 Transport of vitamins, nucleosides, and related molecules 170551 353307 65039 94106 60423 64018 63997 296578 140944 291582 25239 25176 116642 85333 680602 311839 498910 313139 65142 296969 311204 65194 306866 310808 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%10230744 SUMOylation of nuclear envelope proteins 25573 301442 ERKS ARE INACTIVATED%REACTOME%R-RNO-202670.1 ERKs are inactivated 50689 24672 116663 363193 60587 300980 24673 117281 315648 116590 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 97%10228306 Mitochondrial Fatty Acid Beta-Oxidation 100363074 29470 26759 24158 291939 64304 619561 140547 503049 117543 50559 361992 293453 25045 25287 113965 171155 170670 315973 289125 29510 314304 170465 25363 687008 170570 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-RNO-5654219.1 Phospholipase C-mediated cascade: FGFR1 83504 66017 25444 25443 29349 54250 25317 170579 170633 29368 170700 116499 60662 170583 25738 79114 SIGNALING BY NODAL%REACTOME%R-RNO-1181150.1 Signaling by NODAL 50689 50554 25631 116590 294515 29357 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-RNO-9033658.1 Blood group systems biosynthesis 81919 366064 58924 407765 363040 288161 64445 296564 84597 100301568 LIPOPROTEIN METABOLISM%REACTOME%R-RNO-174824.1 Lipoprotein metabolism 58851 300027 293508 300438 25506 140670 313210 25081 24539 83470 25507 25649 291437 64156 54281 25728 100361444 292697 24530 116548 315218 287276 362850 502970 310900 25080 140638 24153 50522 303796 192255 24186 116563 100912032 65046 266732 314459 298296 306825 294930 80848 25073 25292 680551 81782 54225 83800 266770 54241 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%10230402 Phase 4 - resting membrane potential 64119 364241 156873 59324 116491 64120 688996 170899 276720 116489 116649 445371 65272 84429 29712 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%10230218 Advanced glycosylation endproduct receptor signaling 54226 25742 691149 493810 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10228184 RNA Polymerase II Transcription 689116 311796 298075 305455 679203 25309 302415 313558 24370 60331 84482 26195 171335 654441 303393 26198 84683 25329 116723 94194 688386 681024 100188937 54322 364298 360229 24873 25282 29445 140607 24398 102555170 690675 252934 192268 288588 266713 291773 316123 317256 502227 83828 690966 161452 361365 81673 84389 170844 83830 171152 309638 289561 292778 288651 288533 89812 373541 293345 294018 361580 116700 303918 117526 294693 83503 117017 291703 498109 363633 287571 362485 83805 25747 303518 297867 296732 83833 361374 301020 361925 361825 64314 304204 362537 113898 293058 29386 252860 102556092 192350 58839 102553962 296102 259241 58850 58853 308986 102547287 65035 25578 686781 306571 305120 58983 140942 108348224 498160 363292 83826 690728 102555083 54278 365224 295448 286979 100912096 303281 292064 299810 303132 282845 102548695 286996 114510 293044 29338 102549410 290744 303226 306977 315210 102555289 24413 25622 100158223 685619 102546572 307839 102547413 100909569 299694 299210 306998 266734 313131 102550851 314586 315427 287361 306966 24522 25735 78972 300197 116671 306816 365192 306817 81808 313596 25203 245980 54237 116698 266787 102546648 288514 298558 298681 499874 499994 367034 266774 311567 298688 500108 502894 114491 171355 362813 59086 305837 301119 683593 81812 683469 313219 291705 360764 100360287 24377 680200 361988 360896 293625 102555672 114592 287076 156726 311591 314862 314621 84469 120095871 289382 314993 313777 24484 287094 24577 310233 297065 691379 498952 300320 293701 102556967 100362678 297066 312303 25672 498945 360589 117254 291534 291772 102553002 288003 25405 311546 116468 84385 314818 300782 494339 25737 499900 81807 500855 288414 25533 114490 25697 309002 29175 282844 305000 313978 64525 297093 292804 685925 293849 308362 688328 309457 252917 100364132 691610 291164 311414 170955 690895 679713 497923 361487 100362083 246334 29657 117274 60661 680717 100364568 102553866 100365779 306261 362358 308561 308320 308326 365744 308322 246279 311613 300813 304758 100360427 114208 691422 24790 252924 499929 363445 120093538 25631 50659 500715 363227 24666 100365683 680111 499068 362272 361178 29357 286917 84396 361057 690559 363481 246264 303539 100362170 687001 297453 689844 362981 56761 310405 363287 679028 24942 84580 303101 363064 293184 361531 81785 497672 64557 304277 363924 303194 291877 315969 64046 308582 304514 79240 85482 192218 114212 290805 311670 299256 299811 685055 310034 289582 25573 308755 306734 301442 300711 297627 311860 295052 360588 497856 64012 294800 114494 498411 291787 100361529 140583 681062 170824 140923 134478826 296648 24855 116697 683927 315189 310131 84353 365407 314417 686980 311166 50554 81516 690516 81920 313757 361831 304832 25233 366468 501688 116484 25576 689820 56011 297893 25577 313017 309757 50662 361391 64156 288563 315648 24208 295384 362479 360471 50522 50689 24673 192255 497991 25664 114495 312451 100359816 24672 300837 117281 100362634 102550344 116590 100912032 311575 117535 24890 29414 24705 685072 59102 309001 25682 58851 115771 64466 81745 24185 60421 84578 301164 60445 29753 25149 502988 362110 294515 25154 365755 302711 307511 25498 685474 140908 304798 83571 83574 85471 60349 171068 310614 361724 290669 362834 301513 291841 287249 316034 29619 306492 363603 83722 312227 363221 58936 295707 29417 25242 365155 25243 60351 25591 289372 287772 292766 65248 287662 29669 29668 56010 29425 100360846 54281 83712 117263 25581 29666 81650 315606 303353 365388 290829 58919 302783 117262 85492 64562 24829 306945 287984 24828 687711 65138 362093 313048 94198 293615 29673 304809 29671 29670 117056 100362099 29677 64033 681031 680498 691504 29676 362675 29675 307151 685909 25193 313038 680615 304690 309626 363014 365877 25720 310258 81827 303730 171365 25520 25172 315136 116549 680737 83803 681178 24842 83806 313507 311078 500453 308869 361944 310091 25159 298514 501403 303175 64226 171046 295357 114483 373545 688041 297960 26954 117044 117043 64627 362045 690795 56718 304794 360776 AGGREPHAGY%REACTOME%R-RNO-9646399.1 Aggrephagy 29564 100912032 117287 140734 50522 56816 64156 252902 81655 58945 116725 29489 192255 24255 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism 170551 287711 296167 294088 50671 171053 298490 360639 363069 360511 300328 361836 29142 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-RNO-2173795.1 Downregulation of SMAD2 3:SMAD4 transcriptional activity 25591 50554 116590 297893 100912032 81920 50522 50689 313757 64156 114208 499929 361831 363445 25631 24666 192255 29357 84396 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME%R-RNO-73772.1 RNA Polymerase I Promoter Escape 302783 288651 24829 306945 24828 361580 117526 294693 83503 297093 291703 498109 117056 680498 685909 680615 365877 301246 304714 361784 360893 361420 303175 313245 680493 25574 64627 362728 83582 690795 690450 100359714 83581 266713 502227 690966 84389 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) 58919 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 116549 83806 311078 287772 292766 94201 100912032 301555 499342 29669 287643 29668 56010 29425 64156 100360846 117263 25581 29666 81650 303353 365388 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) 246772 282834 687208 364419 362118 297995 365191 287873 681059 50522 498798 108348178 192255 679886 56084 362502 292925 287645 290635 311030 361916 100912032 363720 64156 290775 RAF ACTIVATION%REACTOME%R-RNO-5673000.1 RAF activation 58960 24605 25400 293621 25344 114486 24525 687346 309548 309179 170577 299147 363193 312754 24673 24245 309168 24246 25594 24672 171140 117281 64363 56011 170851 83805 24669 24244 24703 315648 24514 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%10231134 TP53 Regulates Transcription of Death Receptors and Ligands 308986 24484 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-RNO-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands 287910 360579 54226 690158 362454 292419 25380 292409 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 97%10229918 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 314641 25150 246331 309280 289392 316639 312213 29751 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230380 SHC1 events in ERBB2 signaling 29496 498596 432361 24329 117255 59325 25433 64022 25313 170538 85385 24680 29340 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-RNO-9006335.1 Signaling by Erythropoietin 298947 29376 497931 170911 361388 25513 81515 85243 287942 24335 81504 366508 85385 24514 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-RNO-202433.1 Generation of second messenger molecules 300955 294269 29433 300678 313050 81511 25300 25738 24981 25710 29337 499537 24986 29431 24932 29432 366962 363577 310727 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10229342 Gap junction trafficking 266706 79128 116563 84403 25655 50563 50564 394266 25751 29585 497913 29584 315840 24392 29586 79217 83800 54241 363677 266707 116561 140694 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230936 Cilium Assembly 311802 289168 366403 29753 81740 192228 29479 363055 305467 363272 294010 114089 29214 500069 83572 290626 305882 315423 367153 314787 24717 683722 360672 308064 85248 100362495 311573 293844 310344 311529 246150 300963 252921 64462 83567 60347 307347 54237 25515 25273 25411 314961 85258 24650 679894 308443 81830 29167 140734 311191 114764 58945 304007 287612 83836 117103 65209 64158 171044 307724 100362124 316531 305349 303968 295654 116475 296554 64632 29213 288585 60627 300675 365153 312651 298767 503018 100910342 171455 116654 685284 113948 362265 24818 50556 500571 362553 365770 288305 245709 363286 300062 294864 363544 500832 296618 316102 295230 287541 29374 498095 373066 299246 311456 295106 170714 362142 363760 313365 311123 299809 314523 361930 500086 299209 499814 689779 366872 252881 308923 363126 300880 303915 56010 680407 287383 100360427 58822 305287 361789 293148 296136 313170 287836 117515 361727 64664 266809 361178 309486 367714 299850 309451 362675 29489 79120 498102 117281 299979 298555 29885 313993 299331 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-RNO-196854.1 Metabolism of vitamins and cofactors 294972 307096 25216 24185 81522 29216 299857 361266 364773 498790 499330 316062 25668 296167 306262 498789 361300 50671 171053 367323 25551 85496 499328 64392 293504 171516 300886 24778 64001 24244 297508 300328 24539 353255 64845 313241 25649 313520 29319 25728 309465 361751 292697 311536 25035 361472 191574 687008 100125370 361836 289095 25080 170551 288240 301221 64533 287711 29723 24312 294088 362134 299699 298490 83578 291939 360639 363069 680308 360511 303333 362657 751787 64300 315085 295229 25732 298653 363118 296972 305248 50622 54349 60581 50621 29142 365699 290947 362942 691984 171517 24710 25703 24856 25702 25680 192259 116673 24771 299858 362558 64047 317322 25236 315644 58920 314941 25592 25056 55939 54225 293154 81506 25104 309004 313706 300027 50655 24565 399684 25081 29244 29498 171128 29270 25571 316559 305889 680668 303676 289175 25523 25615 24600 24479 314459 498332 308453 365592 80848 498909 296128 366013 304542 299331 299195 291283 361884 360887 25249 313521 29309 307092 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-RNO-9762114.1 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 83619 287280 83806 311078 84027 361765 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%10228154 Switching of origins to a post-replicative state 313138 313479 292071 312538 291927 360621 362304 301430 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 295052 287772 292766 29669 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 117262 85492 294790 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 100912032 361831 288532 316273 295596 296178 29728 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%10229504 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 498666 171369 361795 500910 360548 84349 117516 25008 360640 362788 60371 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%10228576 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 689116 171365 681062 680737 298075 100362099 681031 687711 366468 501688 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-RNO-76061.1 RNA Polymerase III Transcription Initiation From Type 1 Promoter 246299 301246 685539 294687 114205 311487 310685 361102 117526 685465 690254 316810 83503 306012 498109 362095 313914 690966 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation 25467 50689 313845 29376 85385 498416 24506 116590 24505 81504 CELL DIVISION%REACTOME DATABASE ID RELEASE 97%10228870 cell division 290577 304218 313304 63996 290668 305343 315740 25515 361308 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival 50522 25493 24596 84351 363520 64156 310738 311245 192255 113894 100912032 81736 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-RNO-388479.1 Vasopressin-like receptors 25504 24221 25342 25107 25108 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 97%10228594 C6 deamination of adenosine 81635 25367 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375281.1 Hormone ligand-binding receptors 25360 25477 81668 25447 171158 25329 116700 25449 25194 25653 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis 314771 64507 313536 494342 362924 81682 58968 65196 295934 291015 303923 316583 305571 84400 362275 84468 363040 64442 64445 293667 367145 290638 307859 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-RNO-442720.1 CREB1 phosphorylation through the activation of Adenylate Cyclase 25521 25725 29699 293508 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 97%10228840 Amine Oxidase reactions 308652 25750 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%10229902 Signal amplification 294962 301512 25686 25643 83579 680149 24816 83805 58979 64199 286924 114117 303634 24400 79218 25265 81666 81667 245986 81662 60449 81664 64803 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-RNO-6804760.1 Regulation of TP53 Activity through Methylation 24842 289372 114212 689820 100912032 304798 50522 311613 64156 305837 300711 683593 192255 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%10229590 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 24223 24974 680842 24812 499400 64202 58817 24988 93646 29144 297522 685144 24750 295461 25617 365527 287275 287276 29468 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-RNO-5173214.1 O-glycosylation of TSR domain-containing proteins 304135 315263 445442 171569 297757 64456 500032 314655 294809 364630 310207 362539 308787 361886 293004 292406 310670 361412 312566 315879 361332 300474 66015 300475 287899 305253 102554393 299314 315728 474348 306664 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%10229184 Phosphorylation of the APC C 25203 54237 25515 366381 292588 293155 296368 361389 288671 290875 361831 305420 360643 MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis 289777 362960 499870 498265 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 97%10231242 Reelin signalling pathway 25150 24718 84357 266729 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1963642.1 PI3K events in ERBB2 signaling 29496 25433 64022 498596 25313 432361 24329 59325 170911 361388 25513 81504 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-RNO-173736.1 Alternative complement activation 24232 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-RNO-4608870.1 Asymmetric localization of PCP proteins 117262 85492 287984 364754 100360552 65138 303251 64512 94198 317674 29673 50522 29671 29670 29677 29676 29675 192255 64558 81827 83806 311078 287772 292766 100912032 690516 29669 29668 29425 64156 100360846 117263 25581 29666 266715 303353 365388 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-RNO-1296065.1 Inwardly rectifying K+ channels 29718 276720 64199 79218 245986 60449 294962 83579 81657 680149 25559 25743 170847 83535 58979 25560 25472 116649 114117 24400 50599 81667 83633 116560 29713 29712 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 97%10229602 Regulation of KIT signaling 25150 60427 313050 313845 114203 500985 24680 64030 116689 81515 81504 83805 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%10230204 Inflammasomes 304987 300732 117514 282817 29665 360557 290408 315435 287362 58923 24888 116484 301252 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-RNO-6787450.1 tRNA modification in the mitochondrion 319113 PI-3K CASCADE:FGFR1%REACTOME%R-RNO-5654689.1 PI-3K cascade:FGFR1 83504 66017 25444 25443 25622 170911 29349 54250 361388 25513 25317 170579 170633 81504 314850 29368 170700 116499 60662 170583 79114 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-RNO-5666185.1 RHO GTPases Activate Rhotekin and Rhophilins 60377 297383 117273 300030 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-RNO-9955298.1 SLC-mediated transport of organic anions 259248 432363 25246 294255 266998 65202 289459 114511 29735 58978 140860 170698 83500 365398 89776 29509 29743 362188 295417 363103 85426 170943 85254 24221 65200 80878 25027 64201 140915 363024 84511 PI3K CASCADE%REACTOME%R-RNO-109704.1 PI3K Cascade 29376 25443 170911 29348 25233 361388 81745 170579 170633 81504 84477 363131 246273 84489 29516 361992 83504 65052 66017 25444 25622 29349 54250 25513 25317 29369 25022 85243 29368 314850 170700 25467 116499 60662 60464 170583 289625 25114 170582 79114 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10231276 VLDL assembly 25506 25292 680551 54225 310900 TRANSPORT OF FATTY ACIDS%REACTOME%R-RNO-804914.1 Transport of fatty acids 65039 94106 296578 291582 25239 680602 311839 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction 25267 24629 24605 300955 293621 170911 25676 25125 25126 81504 287942 24525 313845 25738 316369 84427 25266 24628 25414 25622 25513 85243 83805 54245 24918 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230174 Nucleosome assembly 298850 302783 65137 363198 308839 684439 288272 289150 24829 689399 361416 306945 689296 316602 24828 499873 313048 362548 685909 680615 365877 681185 303175 306464 679342 25498 64627 690795 307805 83712 25448 305270 315164 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-RNO-3769402.1 Deactivation of the beta-catenin transactivating complex 25578 63879 25233 24185 362093 29417 50522 24205 120099577 503000 84353 691857 65027 192255 25565 295251 289026 312451 310704 312936 361765 102550344 679158 290317 297893 100912032 246768 84424 29382 364712 293165 140586 64156 85252 300673 304794 161452 290829 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%10229432 Signaling by WNT 25578 63879 24185 303251 24525 64199 79218 245986 60449 64558 294962 83579 680149 58979 84424 24244 114117 24400 81667 24681 24680 25023 303811 291678 64512 317674 24205 309179 299147 79257 312754 24881 83721 501584 113927 84353 103691373 679110 116561 116563 690516 83800 289878 161452 54241 266715 29748 304832 688297 365901 362550 306782 314212 100361818 282581 307401 24674 25400 25233 24675 497961 364754 100360552 64303 688319 29417 50664 25388 363875 140670 81717 287772 292766 297893 117273 29669 29382 29668 29425 58822 64156 100360846 117263 25581 29666 315648 81650 303353 365388 290829 117262 85492 287102 80722 293897 287984 295445 313121 502097 114107 65138 100360606 362093 94198 29673 50522 29671 29670 289883 315294 301965 29677 363193 288666 120099577 503000 29676 287357 684097 498997 29675 24673 498233 84426 691857 316526 291209 140584 65027 362065 192255 25565 114850 295251 114487 289026 361846 312451 303586 29134 81827 310704 24672 300837 116549 313589 287280 83806 312936 311078 309419 308051 84027 117281 499918 361765 299802 102550344 679158 290317 266772 500863 100912032 301555 246768 360990 65046 303412 364712 293165 140585 140586 85252 300673 304794 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 97%10230734 SUMO E3 ligases SUMOylate target proteins 83614 690244 58851 315133 310375 313128 83826 501145 297561 304157 25573 308755 297522 291171 301442 499417 690043 290744 25154 296099 24413 25498 117282 308669 60349 362827 313304 63996 116698 300772 24873 83422 60373 81812 114592 64520 64041 500545 300320 25672 84385 24874 25737 64550 361100 299957 367846 313961 60351 691688 363269 361645 293528 102551929 303310 293967 25591 316164 297893 117287 287662 29382 25747 309452 294429 309295 24208 287830 291874 362281 113975 292085 295692 117021 362335 363287 366016 58958 362557 65274 113929 245922 81738 307151 683983 313038 53372 309626 25497 499974 310258 303730 501403 688041 497672 25493 24890 64627 24705 25094 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-RNO-3065679.1 SUMO is proteolytically processed 690244 103689978 78973 301442 690251 499417 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%10230334 Activation of RAS in B cells 24605 293621 29434 24525 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%10228764 Pyroptosis 282834 364419 29197 361916 365191 353316 363720 690675 287873 24493 171528 25402 116502 25309 679886 299606 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-RNO-5661270.1 Formation of xylulose-5-phosphate 78959 24788 316067 290277 171408 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-RNO-8955332.1 Carboxyterminal post-translational modifications of tubulin 298692 292311 690512 311548 689746 315214 362415 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 97%10231484 TYSND1 cleaves peroxisomal proteins 365571 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism 65038 50557 305419 288762 114554 116699 307842 309855 316457 171088 80849 310155 288025 289733 293711 314075 296048 311341 362434 313997 498741 114089 25096 316039 361686 25513 85311 94197 85243 307428 298504 500132 306460 85254 60664 362058 363159 116723 295674 690610 316737 294255 304474 81747 170911 116482 364629 116720 364298 287467 25511 288322 287115 366508 25097 287366 114561 140544 287533 81925 301131 140607 64310 290843 360753 314553 498331 360521 192259 192260 362702 300147 302425 293620 305935 361632 361401 362972 289021 314641 361659 681694 89812 361676 361433 114101 360426 691478 361694 363131 25062 361467 363521 246237 286936 65052 64633 680971 295417 678749 296623 308584 367786 310773 29367 60418 89841 310663 171155 60666 360843 170670 29194 305482 365865 170919 29510 282584 362249 317296 312634 81650 311821 306490 85238 305166 296130 29653 298947 25532 84497 252900 497931 29254 497932 84018 362039 116549 691905 294324 29354 24913 309419 29692 366196 308309 295631 84470 298579 29526 140940 29359 297694 296128 54259 363024 PROTEIN HYDROXYLATION%REACTOME%R-RNO-9629569.1 Protein hydroxylation 293418 266670 29304 124323 360665 305470 362154 100137086 26962 308976 307503 314300 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230832 SUMOylation of DNA replication proteins 287830 83614 291874 690244 362827 362281 113975 292085 295692 117021 362335 25737 366016 58958 362557 25573 65274 113929 301442 245922 499417 64550 81738 361100 683983 53372 25497 499974 114592 64041 500545 294429 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 97%10228650 Base-Excision Repair, AP Site Formation 307798 307861 302783 24829 306945 303175 24828 170841 680915 367090 315344 305957 81528 64627 690795 685909 680615 290232 297758 365877 500054 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228320 Phenylalanine and tyrosine metabolism 29700 681913 100360621 29383 246307 311844 24813 29531 64192 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%10231302 MET activates STAT3 24553 24446 25125 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10229998 Small interfering RNA (siRNA) biogenesis 64028 298533 311130 299284 363006 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230872 Hedgehog ligand biogenesis 117262 85492 311324 499241 84399 287984 361712 65138 84380 94198 29673 50522 29671 29670 29677 29676 29675 116643 192255 29499 81827 83806 25506 311078 362891 289874 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 303743 365388 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%10231626 Regulation of Expression and Function of Type I Classical Cadherins 314641 83427 50654 83502 25697 25150 266758 292064 293142 84430 688673 25705 81717 500569 287772 689820 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 25507 29425 64156 100360846 54281 83712 117263 25581 29666 81650 303353 365388 302783 117262 85492 192275 313474 24829 306945 287984 24828 65138 313048 94198 29673 50522 305679 100188932 29671 29670 117056 29677 680498 29676 29675 84353 685909 680615 192255 365877 686092 81679 81827 116549 311163 83806 311078 313648 303175 688041 100912032 300445 29144 64701 29606 64627 25751 500870 78947 690795 293721 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME%R-RNO-2142691.1 Synthesis of Leukotrienes (LT) and Eoxins (EX) 266674 298423 81639 286904 114097 24306 299732 299566 503122 29624 50549 25290 291984 289014 94199 29566 116568 24565 24307 290623 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-RNO-1236977.1 Endosomal Vacuolar pathway 24988 24223 24750 24974 680842 171105 365527 499400 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME DATABASE ID RELEASE 97%10231404 Noncanonical activation of NOTCH3 81751 29192 292788 56761 300802 500538 289231 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-RNO-6807878.1 COPI-mediated anterograde transport 503165 60355 192243 289257 305614 64159 79117 29564 314251 252889 29631 314030 308458 294010 84428 60384 300674 291990 299121 246310 54400 64528 171049 84599 64154 362162 25407 361073 94189 361207 290659 64351 65134 297428 361577 304290 363136 293456 299850 309451 252902 81754 29489 300888 24506 24505 79120 64310 114023 304978 310411 140940 140673 29167 65165 140734 56042 81655 58945 690961 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%10230148 AUF1 (hnRNP D0) binds and destabilizes mRNA 117262 85492 171350 287984 65138 94198 29673 50522 29671 29670 24472 29677 29676 29675 192255 81827 79256 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 24468 117263 25581 29666 303353 365388 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME DATABASE ID RELEASE 97%10230812 EPH-ephrin mediated repulsion of cells 81751 304109 686310 24338 300802 287989 289231 81515 312275 81687 83805 295378 25150 81686 29192 360546 292788 306636 363875 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229384 Mineralocorticoid biosynthesis 360348 25329 116700 24470 682974 29632 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 65194 353307 60423 63997 140944 25176 116642 85333 498910 65142 VITAMINS%REACTOME%R-RNO-211916.1 Vitamins 312495 25279 308190 114700 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism 316033 310508 500961 363494 114104 65196 303729 25227 311013 316642 83537 303631 117185 289687 25524 94338 315222 24800 365619 407765 310326 684536 362409 307404 116740 84431 312689 83626 81919 83505 58924 300757 64828 365984 683713 301525 50555 362275 300129 364901 64442 63888 64445 294673 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-RNO-75105.1 Fatty acyl-CoA biosynthesis 364134 361895 498728 191576 117243 300783 359725 361802 680115 84013 117182 60581 65192 50671 25288 301120 29411 309449 114024 113976 246074 171410 171402 24159 171400 94340 54398 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%10228348 Cytosolic tRNA aminoacylation FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%10228640 Formation of Incision Complex in GG-NER 83614 690244 288651 361580 287927 294693 50522 300772 25573 291703 301442 499417 192255 313098 302502 361381 290027 25591 100912032 300813 304719 64156 266713 100362121 116725 310707 502227 361181 59102 298012 84389 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%10228302 Citric acid cycle (TCA cycle) 114597 157074 24368 114096 293615 361596 298942 79250 81829 288740 170587 360975 363061 298596 361726 287069 310378 289217 25014 94173 362323 290985 499125 299201 102550385 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-RNO-888590.1 GABA synthesis, release, reuptake and degradation 171163 24380 50676 25531 83612 84556 64832 81632 79213 24379 79212 79130 25012 24468 25716 25558 116470 24803 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-6791312.1 TP53 Regulates Transcription of Cell Cycle Genes 83722 312227 363221 25203 58936 295707 295052 54237 314818 307511 25737 25498 313017 83571 114494 362485 301513 291841 287249 316034 29619 306492 363603 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-RNO-5654726.1 Negative regulation of FGFR1 signaling 25443 170579 170633 500526 81504 114486 50522 50689 24673 500985 192255 83504 306141 24672 66017 25444 25622 117281 29349 54250 116590 25317 100912032 83805 29368 314850 170700 116499 60662 170583 64156 79114 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 97%10231314 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 302783 24829 306945 24828 60421 362093 301164 117056 680498 691504 685909 680615 365877 100359816 25172 100362634 303175 102550344 297893 64627 50662 361391 690795 304794 315606 290829 295384 309001 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-RNO-445989.1 TAK1-dependent IKK and NF-kappa-B activation 310877 363520 291921 64044 313121 287707 50522 84351 315599 500900 192255 362418 308267 291861 100912032 317546 81736 25493 312688 54226 64156 309361 25742 116725 311245 309452 309295 CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228738 Cam-PDE 1 activation 24244 81742 29691 PROTEIN UBIQUITINATION%REACTOME%R-RNO-8852135.1 Protein ubiquitination 25737 287927 641452 292588 296368 313216 297593 363836 360847 360748 303478 100909445 100362554 64156 116725 363445 498560 266712 297337 689226 362412 308282 295568 116718 24829 293561 306945 500636 64460 360471 307029 305581 50522 29534 363064 293184 361531 305268 192255 300837 81816 312703 314432 100912032 81920 117044 680424 64631 361831 83477 304832 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-RNO-114604.1 GPVI-mediated activation cascade 25441 298947 497931 170911 25155 497932 81745 295378 25150 81511 29337 363875 308875 64465 54320 25622 25513 81515 500336 85243 117273 684555 64373 313050 60664 116689 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 97%10228370 Recycling of eIF2:GDP 54318 64514 299027 192234 296302 171145 117019 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230576 CS-GAG biosynthesis 50568 25181 291577 291770 297554 500257 29139 304322 302302 286974 314694 316533 361450 84468 25393 81651 114122 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-RNO-205017.1 NFG and proNGF binds to p75NTR 24596 310738 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins 298850 681050 83836 314212 295661 363059 363198 304951 79115 684439 289150 361416 304477 29564 65201 290396 64303 303251 297522 363875 83572 300225 117273 64373 360840 315648 294429 287830 501099 287746 292085 25515 287624 303811 94266 309179 299147 252902 363193 312754 83721 24673 29489 81738 362548 683983 287876 29648 363174 24672 64515 64465 681185 297176 298594 114592 170845 117281 81822 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 85252 307805 81655 311191 114764 58945 500545 25448 305270 363028 286993 102555739 315164 81531 114514 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 25227 25295 311013 81716 307503 303631 315222 266670 24800 365619 310326 360665 362409 307404 306608 260320 302470 124323 305470 362154 100137086 24946 308976 314300 25268 288923 29565 293418 310261 362191 295394 29243 303755 288617 29304 287444 498034 170818 54281 314644 26962 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%10230572 Pre-NOTCH Expression and Processing 84006 304815 56761 65165 NUCLEOTIDE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleotide catabolism 116593 81656 287368 65135 312373 289801 311580 295620 315219 85260 64467 309390 316077 613267 314312 311422 171047 361068 100363253 361274 287406 305149 313574 117260 298881 497811 290029 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 97%10231704 PDH complex synthesizes acetyl-CoA from PYR 289950 117098 298942 81654 311254 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex 366381 292588 293155 296368 64515 361389 288671 297176 290875 361831 305420 360643 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME%R-RNO-73863.1 RNA Polymerase I Transcription Termination 301246 288651 361784 360893 361420 361580 117526 294693 313245 83503 680493 25574 291703 362728 498109 83582 690450 83581 266713 502227 690966 84389 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 97%10229562 CLEC7A (Dectin-1) signaling 100361818 361400 24674 24675 81745 641452 29337 307366 287772 292766 83805 29669 24244 29668 170538 29425 64156 100360846 116725 117263 25581 311245 29666 309452 303353 309295 365388 117262 85492 64044 287984 313121 65138 94198 502902 29673 50522 282817 29671 84351 64171 29670 29677 29676 29675 192255 81827 287280 83806 311078 308267 361765 100912032 117553 317546 81736 25493 309361 361831 303024 360640 29748 83477 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%10231628 Degradation of CDH1 117262 85492 83427 313474 50654 287984 83502 65138 25697 94198 29673 50522 25150 29671 29670 29677 29676 29675 292064 84353 192255 81679 81827 311163 83806 311078 287772 292766 100912032 83805 29669 29668 500870 25751 29425 64156 100360846 117263 25581 29666 303353 365388 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 97%10229150 Signalling to RAS 313845 289014 24605 293621 85385 315994 81504 314612 29622 24525 METABOLISM OF COFACTORS%REACTOME%R-RNO-8978934.1 Metabolism of cofactors 25523 24600 24479 24185 24244 498332 29244 308453 365592 29498 498909 171128 296128 29270 366013 50655 304542 299195 299331 360887 25249 313521 29309 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%10230574 Regulation of innate immune responses to cytosolic DNA 50522 314336 292892 299827 64156 499069 498840 308901 192255 313264 100912032 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%10229820 Adipogenesis 84578 25664 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10230962 RHOQ GTPase cycle 116717 83709 170824 29448 311647 307035 304546 310621 290396 117955 314249 312108 303653 114116 29431 29432 24392 292756 315121 24255 362938 81679 64630 309175 64465 64678 306400 114559 63994 29528 308869 362842 192348 85428 310074 362988 29491 291999 299012 307459 360840 313838 66013 113960 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 97%10228998 Formation of ATP by chemiosmotic coupling 245958 140608 300677 171082 94271 245965 171069 29754 362749 641434 690441 171375 192241 65262 171374 26197 26196 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%10228960 Synthesis of substrates in N-glycan biosythesis 316033 29640 296394 362924 502017 291325 363109 297393 25197 116696 498272 297417 498486 117523 360518 302972 81759 25547 83505 313139 311204 305291 365984 81726 298071 310935 114711 291095 501167 316642 117185 311530 300089 293587 302915 303692 407765 25280 301155 300741 287920 299346 298541 311847 29758 295051 288525 294400 363103 304860 364901 363040 64442 64445 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230428 GRB2 events in ERBB2 signaling 25433 64022 498596 432361 313845 24605 59325 293621 81504 24525 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 97%10229386 Metabolism of steroid hormones 64677 25557 116700 24470 682974 29632 299270 25146 25116 360348 25117 79122 24800 289456 29189 116463 84013 313786 691018 25322 296972 79243 117182 29680 24192 24950 305291 291699 25329 24230 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-RNO-480985.1 Synthesis of dolichyl-phosphate-glucose 295051 299346 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-RNO-195399.1 VEGF binds to VEGFR leading to receptor dimerization 114111 89811 360457 94203 83785 25589 114110 COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229440 Coenzyme A biosynthesis 360511 287711 296167 294088 298490 360639 363069 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%10229192 Mitotic Anaphase 364419 363059 29564 25573 297522 301442 83572 679886 361916 290577 304218 313304 25203 63996 684771 54237 305343 25437 25515 114087 365191 94266 309179 299147 312754 29648 116685 363174 64515 681185 297176 298594 114592 170845 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 307805 311191 361831 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 282834 83836 295661 363198 682908 304951 64158 684439 500377 289150 117104 361416 307833 304477 246118 500363 300218 498736 65201 316531 307351 366381 291081 84509 292588 313478 293155 296368 679312 361389 296554 288671 29213 290875 362700 305420 360643 500929 287772 292766 363720 29669 29668 29425 64156 100360846 117263 25581 29666 315648 303353 294429 365388 287830 291874 246772 363481 113975 117262 85492 64193 292085 295692 117021 362335 287984 287624 65138 366016 94198 29673 287873 50522 362557 29671 29670 252902 29677 363193 29676 29675 29489 81738 24673 362548 683983 192255 81827 24672 83806 311078 117281 100912032 85252 81655 24917 DUAL INCISION IN TC-NER%REACTOME DATABASE ID RELEASE 97%10231094 Dual incision in TC-NER 366163 299112 171525 298098 289561 288003 245976 292778 288651 362385 116468 314061 362479 497967 360471 25737 361580 306274 304573 288414 294693 83503 117017 50522 291703 498109 363633 192255 302502 362394 59294 100912032 304719 288588 64156 289758 266713 246216 502227 361181 89809 59102 690966 361365 84389 361698 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%10230400 Classical Kir channels 116649 276720 29712 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-RNO-8866911.1 TFAP2 (AP-2) family regulates transcription of cell cycle factors 304809 24577 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors 56820 116506 58965 25026 58966 24241 25029 399475 24476 171519 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190377.1 FGFR2b ligand binding and activation 25443 29348 54250 170579 25317 170633 25022 64535 499349 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%10230656 Anchoring fibril formation 678743 83470 365460 301012 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-RNO-9754119.1 Drug-mediated inhibition of CDK4 CDK6 activity 58919 64033 25193 114483 94201 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%10230760 Regulation of TP53 Activity through Acetylation 140607 290744 24842 315210 306571 361374 89812 25233 310614 24185 361724 363292 297893 364298 290669 362834 313048 117535 29414 83712 116723 679713 114495 MRNA EDITING%REACTOME DATABASE ID RELEASE 97%10228480 mRNA Editing 301226 25383 498251 170912 81635 25367 CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-RNO-389359.1 CD28 dependent Vav1 pathway 29433 25150 56822 313050 64465 29431 29432 363875 25660 25408 81504 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230302 Antigen processing: Ubiquitination & Proteasome degradation 287927 297930 308669 690516 81920 361831 366381 292588 296368 56816 361389 288671 290875 305420 360643 363836 287155 289508 64156 116725 294790 311373 140593 293060 362277 361187 687633 50522 315608 50558 361866 192351 360534 316395 317241 362294 315863 29274 305268 140939 192255 303963 295252 316005 353227 314613 313525 305351 301674 287280 303735 295704 363284 500017 361765 64624 299197 498726 500262 117553 100912032 140941 308999 60383 306417 289437 64631 155812 64517 362081 310363 303024 313743 362511 498959 100360914 503446 308283 302987 288596 304920 308968 293023 287706 494223 685029 362087 499114 171043 619577 288921 688993 313722 309591 367785 363188 305792 292757 360926 301515 316575 290692 100909827 683077 282845 312647 361219 498005 360818 361907 687364 89829 302938 685860 309453 690769 171136 500532 303478 100909445 306505 94196 500511 362566 306750 303689 296988 363790 652955 311866 313806 308901 303336 313264 297961 311881 301042 362900 300950 291597 689226 117537 361268 316614 303792 300724 300849 117524 311567 300968 313115 297592 362367 316628 499877 364681 298689 25489 313445 192256 362377 362376 309758 362814 306129 366854 64515 367167 81816 313101 501546 314432 81815 171105 296161 500587 24874 81807 641452 64525 287772 292766 29669 29668 300813 29425 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 94198 29673 29671 29670 29677 29676 29675 81827 83806 311078 301555 306825 UNWINDING OF DNA%REACTOME DATABASE ID RELEASE 97%10229238 Unwinding of DNA 292058 307639 499914 290842 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231430 Biosynthesis of aspirin-triggered D-series resolvins 29328 299732 25290 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230044 Unblocking of NMDA receptors, glutamate binding and activation 24408 29495 24410 83613 171140 25400 64053 50592 29629 29628 29627 25252 24244 24412 24411 58948 117284 24409 24245 24246 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-RNO-114508.1 Effects of PIP2 hydrolysis 309207 688705 25666 29254 25262 25679 497978 81678 499913 305795 81821 170538 60395 140866 100361138 54248 29340 81749 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%10230124 Mitochondrial tRNA aminoacylation 310856 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 97%10228700 CaMK IV-mediated phosphorylation of CREB 24244 83506 25050 60341 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 97%10228634 Axon guidance 313644 60629 29376 297518 24605 83510 289257 29423 293621 305614 64159 306628 24586 314251 361597 81504 24525 310207 25614 25150 116696 84477 313498 313845 117523 361364 308458 290905 362572 301252 266729 288669 84427 293508 65208 25622 310630 116690 54319 25513 85243 84393 29751 140908 64373 24716 24718 60664 85385 24680 312477 286908 116671 171119 498898 25136 300955 316639 170911 361388 78966 29302 360854 366508 296456 171574 310192 246331 116563 306400 116743 366492 81824 170851 314850 25751 24553 83800 54241 314641 295378 25738 29431 59312 29432 363875 25311 24511 140670 685269 498416 81515 117273 83805 362993 364686 84357 312213 81650 79114 140694 81732 311384 50687 24410 315615 83709 24699 24329 686310 58960 24338 84009 316539 300802 502694 287989 299737 25676 312275 81687 116683 310643 29433 50689 309280 84358 81686 25454 29192 315711 79208 360546 316009 171287 292788 94268 306636 298528 25453 287876 316369 312279 289820 361882 501203 81751 289392 304109 24408 361537 64465 116549 114559 25615 25537 84027 29210 81822 66023 83841 54227 116590 289231 29491 306790 65046 81521 296789 25525 361568 25418 25415 25417 299331 25416 363517 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME%R-RNO-2473224.1 Antagonism of Activin by Follistatin 29200 25196 24373 PTK6 ACTIVATES STAT3%REACTOME%R-RNO-8849474.1 PTK6 Activates STAT3 89829 366275 25125 PLC BETA MEDIATED EVENTS%REACTOME%R-RNO-112043.1 PLC beta mediated events 24654 83506 81636 25238 25031 293508 302950 85240 64532 25521 25289 25725 29241 116590 84420 24244 170538 64508 81742 25050 81666 24681 29699 24680 81662 60341 29691 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol 290651 316376 85238 83523 116699 282636 252899 171088 80849 365382 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%10228402 Ketone body metabolism 314800 25014 117099 367112 366463 295458 690163 24450 65984 79238 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%10228126 Assembly of the ORC complex at the origin of replication 313138 313479 302783 24829 291927 306945 303175 24828 362304 301430 64627 117056 690795 680498 685909 362607 680615 24917 295596 365877 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-RNO-168179.1 Toll Like Receptor TLR1:TLR2 Cascade 680127 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 REGULATION OF TNFR1 SIGNALING%REACTOME%R-RNO-5357905.1 Regulation of TNFR1 signaling 688466 81859 687813 498803 83427 115771 114210 312937 64044 364386 63879 25625 246244 641452 50522 84351 289014 246294 266610 306886 117279 192255 246756 60371 363836 299827 287155 360827 94193 100912032 100362554 81920 60383 64156 309361 361831 311401 308493 362828 24835 309295 290864 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229826 Mitochondrial ABC transporters 362302 140669 302395 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%10229800 Centrosome maturation 83836 64158 311802 306599 366403 316531 29753 81740 192228 29479 296554 363055 29213 305467 294010 29214 500069 692032 83572 290626 305882 309098 315423 171566 367153 314787 683722 360672 308064 100362495 362980 311573 293844 310344 56010 311529 362203 58822 287929 246150 300963 308663 252921 64462 680991 60347 307347 54237 25515 299850 29489 117281 29167 311191 114764 58945 299331 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%10229652 PRC2 methylates histones and DNA 444984 302783 24829 306945 303175 24828 688041 313048 64627 681740 117056 690795 296653 680498 83712 691153 685909 680615 365877 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 97%10231556 Prednisone ADME 307096 498789 171516 266685 501907 299270 286954 25116 286989 25117 361266 291283 191574 364773 266682 498790 307092 24186 252931 G2 PHASE%REACTOME%R-RNO-68911.1 G2 Phase 114494 399489 295052 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%10229458 AKT phosphorylates targets in the cytosol 83571 296988 29414 309361 292887 58918 25233 24855 24185 GLYCINE DEGRADATION%REACTOME%R-RNO-6783984.1 Glycine degradation 298942 171133 306586 299201 360975 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway 29582 RNA POLYMERASE I PROMOTER OPENING%REACTOME%R-RNO-73728.1 RNA Polymerase I Promoter Opening 25574 50689 100359714 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-RNO-69273.1 Cyclin A B1 B2 associated events during G2 M transition 25203 54237 308768 117104 306102 689296 25515 316602 361088 24673 682033 363174 24672 295052 361613 117281 361643 307511 171102 171103 308937 287101 114494 85252 266713 315648 84389 SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 29496 498596 432361 298787 24329 59325 24605 293621 170911 25233 361388 24185 81504 24525 50522 25150 313845 192255 84427 362814 366275 287155 117255 64624 25513 100912032 117273 83805 25433 64022 170538 25313 29414 64156 85385 299331 24680 296121 29340 114562 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%10230116 Interleukin-6 family signaling 89829 245983 25622 25125 81680 24498 290655 289747 310132 313173 500985 25707 100361294 688622 24514 29201 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements 25578 300944 29344 300045 361109 171350 24185 307947 79256 307850 287772 56011 292766 29669 29668 170538 29425 64156 100360846 117263 25581 29666 24680 303353 365388 117262 85492 363854 287984 25379 65138 94198 29673 50522 29671 29670 289014 24472 29677 29676 29675 192255 366017 81827 83806 294975 311078 100912032 85252 79426 24468 679140 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 97%10229606 Regulation of thyroid hormone activity 65162 29475 25430 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 97%10230898 Phase 3 - rapid repolarisation 171138 367302 246150 117018 84020 25470 63883 681190 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231358 RHOA GTPase cycle 361940 60431 78967 360509 290396 314249 312108 362456 305234 25096 498282 296323 309696 310833 306183 312113 308097 25513 306357 306279 246249 688429 362893 314618 288093 307459 305156 367085 498130 314903 305367 361617 306618 303222 303501 317598 287537 287418 64351 83620 307098 120099896 311647 310635 310999 25270 78966 140898 361921 29355 117020 307170 301334 310192 114513 293024 362648 81679 361029 64678 306400 116666 310074 299012 29275 363031 503306 314212 29681 297383 296060 310621 360942 295378 54308 64665 83764 366170 679082 296162 300030 300115 64630 300225 83615 303611 117273 171296 293947 312640 79239 313618 100363276 54350 291000 363213 65134 84009 360678 361882 304109 114559 25537 29528 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-RNO-168142.1 Toll Like Receptor 10 (TLR10) Cascade 64156 25742 81647 116725 314322 311245 315648 305355 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%10231240 VLDL clearance 25292 680551 54225 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 97%10229186 APC C:Cdc20 mediated degradation of Cyclin B 64515 25203 54237 100912032 366381 50522 292588 293155 296368 361389 64156 288671 290875 361831 305420 360643 192255 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 97%10229628 Platelet Adhesion to exposed collagen 25150 25441 81515 684555 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%10230492 Molecules associated with elastic fibres 292734 25717 311061 362800 59107 59106 24511 83838 29158 29302 29373 85272 313662 500245 296456 59086 252835 293677 81809 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%10228660 DNA Damage Bypass 309812 299112 316235 171525 298098 288003 362412 362385 116468 298693 25737 304573 288414 50522 363164 116643 292101 300795 84478 307905 192255 140639 302502 313387 100147704 59294 81816 295704 289508 100912032 289758 64156 316344 361181 89809 59102 313702 361698 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases 293625 300711 64314 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230050 Type I hemidesmosome assembly 64315 691517 25724 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-RNO-196836.1 Vitamin C (ascorbate) metabolism 309465 25551 25035 50622 50621 64001 24778 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 97%10229828 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 171101 25253 25608 302813 266607 294075 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME%R-RNO-112308.1 Presynaptic depolarization and calcium channel opening 25297 84347 140725 50688 300992 116600 306243 58942 25398 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5685938.1 HDR through Single Strand Annealing (SSA) 85482 288003 116468 192218 290805 288414 685055 310034 297561 305000 308755 306734 300711 297627 311860 360588 497856 64012 499870 294800 497672 64557 304719 498411 363924 303194 315969 291787 100361529 59102 64046 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-RNO-400511.1 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 25253 25040 302813 266607 VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction 307096 25216 307401 266761 300027 29216 361266 259274 353252 364773 498790 498789 24717 83579 313689 680149 363071 171516 293049 314264 64511 266714 25081 24244 24711 24539 89826 24400 25318 25649 25728 292697 191574 25080 499132 317498 316218 85259 296972 363143 291318 301233 29481 140936 64370 25539 116556 59077 691984 79222 299521 171517 25615 81760 24710 25703 24856 25702 25680 192259 116673 24771 299858 362558 64047 89810 317322 25236 302425 315644 58920 314941 25592 25056 55939 54225 289878 291283 81644 307092 688297 SYNTHESIS OF PS%REACTOME%R-RNO-1483101.1 Synthesis of PS 293620 314553 SIGNALING PATHWAYS%REACTOME%R-RNO-162582.1 Signaling Pathways 689116 298075 361940 60431 78967 305457 307035 360509 290396 307562 366608 314249 312108 360500 305987 315992 362456 299857 305234 292756 308509 315121 29579 309168 25096 308875 498282 296323 309696 310833 306183 305938 63994 312113 362842 313438 308097 500287 306357 306279 246249 291694 688429 362893 314618 288093 307459 305156 367085 498130 313388 360840 314903 309362 305367 361617 303583 84014 303222 303501 295635 304282 29146 287746 500246 83620 84031 316639 300067 307016 300186 304546 292279 302976 311450 29355 304530 311793 308021 303653 114116 25097 114243 306871 60371 363836 287155 64624 60383 306417 308968 100909827 362566 296988 25489 362814 287156 192647 171086 497974 24644 81737 25054 25730 24225 360606 298947 64545 497931 497932 300160 114612 25594 140931 29497 117259 29578 64200 500538 365407 117538 259242 367901 50662 361391 361396 64156 364686 81647 314322 304813 311245 114004 315648 298144 116670 309295 24208 81771 311061 117269 363520 170921 287102 64044 80722 293897 295445 313121 362491 502097 114107 50522 50689 84351 24516 289014 363193 301965 120099577 503000 498997 24673 498233 691857 315994 291209 65027 192255 25565 295251 315305 289026 312451 501560 29134 310704 24672 300837 116554 313589 287280 312936 300980 309419 308051 308267 499918 117281 361765 299802 679158 116590 290317 266772 500863 100912032 317546 246768 360990 81736 303412 25493 364712 293165 116663 140585 54226 140586 309361 300673 60587 24592 360814 25597 314596 192126 29372 304893 24835 290864 688466 81859 687813 498803 83427 115771 114210 312937 364386 64199 24654 286924 83506 24611 79218 360616 24627 24626 25638 81636 245986 25238 24668 60449 84427 25031 293508 302950 85240 294962 64532 25521 25686 25289 25643 25601 25725 83579 29241 680149 84420 58979 140908 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 81662 81664 60341 29691 25270 307170 65183 300289 65189 305922 65157 297387 308265 311622 299116 360920 362279 308761 29275 56785 64160 363031 83809 498174 309722 81531 304007 315265 503306 365355 305341 685357 79115 29681 297406 295588 297383 94195 296060 360942 117955 315686 367235 361813 54308 305605 24852 192277 310090 366170 498547 303888 116547 679082 296162 313216 300030 171581 500929 300115 315732 309175 25230 25591 690130 310013 300225 288057 303611 85428 289874 287772 300111 292766 362988 94201 291999 362993 171296 65248 29669 246314 29668 293947 312640 360596 56010 299145 29425 100360846 313618 100363276 83712 678766 313838 117263 317296 25581 29666 689997 367902 81650 300838 29745 303353 365388 311721 113960 290829 291000 58919 83425 302783 84510 117262 501099 85492 363213 306004 64562 24829 306945 287984 24828 65138 362093 313048 94198 29673 29671 29670 117056 29677 680498 29676 29675 116643 685909 680615 365877 81827 294048 25520 116549 83803 83806 311078 84027 362891 303175 373545 688041 301555 287643 56822 64627 690795 304794 66025 306792 298062 60399 310812 116744 29415 29733 500317 50557 24605 289257 293621 305614 64159 306628 25660 24586 314251 81504 25408 24525 25614 25150 313845 308458 290905 363272 302415 313558 84482 25488 288588 316123 83828 690966 361365 83830 289561 292778 117526 83503 303517 117017 309816 498109 691517 363633 294075 25196 170897 81515 59301 117273 83805 313050 24482 116479 81918 24703 64030 24514 58960 25454 170577 316009 25453 140928 63885 25523 24600 81743 171115 25262 66023 113894 25466 24498 25467 25525 361749 54245 24918 25326 25578 29376 287942 361597 25556 84477 171081 362572 25402 500985 60427 89829 299827 84492 25506 25622 25746 301059 25513 85243 116630 25613 24716 60664 85385 25704 100361294 116689 312477 25136 116562 170911 25155 50646 300177 25125 25126 366508 25740 362477 308118 59086 24373 25273 29381 113927 310655 245921 81809 297699 116685 313477 81810 292734 25717 29591 362800 59107 64678 116743 59106 83837 83838 25306 89816 25387 83800 54241 24483 25679 81678 60395 266610 306886 25388 29636 116498 24255 54350 81732 24827 65134 287624 246294 29489 289820 24807 171549 192348 29491 65165 65046 316226 81655 116717 361696 79240 81645 363059 297518 360915 29448 29564 303251 297522 291171 500572 310306 79209 309922 288669 64558 311331 360658 292770 29135 50866 360827 94193 64351 81922 313474 24855 498798 360854 29183 24506 24505 116561 81921 116563 116666 311030 81824 140734 64022 58945 25108 314641 25233 84589 315840 117550 64630 140670 25433 25313 84357 24221 171041 24329 292994 25532 360471 252902 363143 29481 79121 261736 29528 361120 117535 314910 114090 29414 300078 367915 117277 313934 117039 314906 503165 59325 500409 362950 307810 24185 361655 60445 29753 24180 24392 83572 56084 25490 25372 363235 366275 117268 170843 64015 29304 94266 100362346 310614 361724 290669 362834 64520 311332 84010 294924 296472 58822 54248 81749 294429 287830 688705 292085 445442 29254 305795 305679 81738 114203 683983 24628 25639 292887 308869 310091 298514 64226 295357 116636 25435 297960 26954 81821 117044 117043 117045 83840 140866 362045 100361138 56718 360776 25692 25666 89807 287730 497978 24816 24938 499913 25107 25229 688605 689936 316019 29385 246075 379044 282832 25340 554302 50672 25342 29141 60590 292409 58959 64042 309207 53949 25266 308408 25477 294394 246759 58965 29397 24260 58966 25593 25111 292419 29151 24476 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25329 25449 116723 81753 29363 54258 500157 84348 25321 24232 81752 24473 305236 50577 289023 171551 65032 24925 24806 24808 24929 290493 292794 117549 24247 316259 295144 316137 192223 317219 25570 81503 24241 29256 498289 362505 100360071 497196 100911796 497078 140607 25542 24695 64636 302619 81648 299242 117264 57305 81657 353250 308163 84007 24694 117027 57302 89810 100270683 360579 29581 171056 365228 306307 25555 29238 89808 81644 689869 29595 29237 192205 29235 192206 170634 29597 29234 84475 29471 171044 24318 89812 102552838 360918 294123 116700 314386 171519 24797 294124 685243 24677 25524 25645 294121 25083 114098 114099 29446 81672 25087 84023 399475 294807 25653 25652 24323 24326 81779 24448 81668 29335 301086 690158 367315 24418 24659 266997 24417 24419 24772 114105 24414 365865 60628 24416 25504 24415 445269 309212 25187 83633 78964 500091 171371 494319 497942 56813 117064 64680 498475 192648 192649 246358 29316 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 56820 310444 25075 25195 29555 192646 310327 501177 500089 100310876 301066 25726 25605 113914 679957 287910 298006 116506 25723 24875 29407 25040 78981 78980 171158 78983 362454 78985 498335 117041 25616 366270 24769 366274 29538 117029 245920 83518 24889 246219 266607 60669 25051 60665 29413 29412 78976 25298 679975 54305 85268 78979 302378 25706 25026 170926 24179 259224 259222 25029 24613 25380 25264 24174 690448 24175 25024 60432 25265 361383 363682 29180 288995 378939 498791 691774 116677 319107 64803 319105 24182 25033 29191 287673 499194 113959 24717 25245 25369 63843 25248 170704 117518 24953 25007 260319 60337 680188 25360 58812 287561 287562 24604 63850 502757 171104 171108 500101 83567 24166 310869 29290 171101 58949 54237 25023 25437 25515 304591 311567 302855 291755 301007 29648 293497 363009 116478 362938 362859 315829 303553 361029 306400 287543 366492 289229 306506 360849 498331 314621 310074 312077 316213 314850 299012 312667 192207 305645 140922 295378 81511 25738 29431 29432 366962 363875 24188 24511 66017 25444 29349 54250 25317 29369 25022 29368 170700 116499 60662 60464 170583 289625 25114 170582 315707 79114 83823 29610 24410 83709 84009 300802 25676 81687 29433 81686 29192 292788 287876 316369 361882 81751 304109 24408 64465 114559 25537 81822 54227 289231 59265 686412 294235 315093 25267 24629 192218 301128 65179 311860 140583 170824 25443 29348 361388 170579 170633 303811 291678 64512 317674 24205 309179 299147 79257 312754 24881 83721 501584 84353 103691373 679110 290921 25366 79210 81507 29200 499508 59328 29263 85435 50554 310914 289264 367100 25378 25237 81516 24504 140590 29530 690516 81920 29373 25671 500245 313757 59075 500485 50678 308776 363455 361831 309962 24553 24697 24446 312574 296121 117063 303743 304832 289711 289712 287612 59320 65209 311324 499241 304729 296532 84399 307724 361712 308577 100362124 84380 305349 303968 295654 289180 116475 364475 361769 89830 691171 50938 312651 503018 362265 29499 140588 140589 81818 81717 500569 297893 29382 59109 310738 25625 289883 315294 288666 287357 684097 84426 316526 140584 362065 114850 114487 361846 303586 296849 311254 25061 311764 24890 29149 497941 85252 24705 500633 685072 685750 299331 291283 360420 24919 307092 170906 25682 58851 307096 246332 363026 363425 266603 266686 64466 308190 25335 81745 60421 84578 301164 361810 304157 289950 298942 25149 81654 24172 361266 81530 89813 362110 353252 301252 364773 294515 498790 25718 362809 260321 117098 25154 170635 498789 365755 302711 500629 25522 313210 29563 313689 171516 116676 84424 83571 83574 361967 85471 297805 312495 60349 298184 25098 171068 140868 191574 29340 306618 66013 500608 317598 298404 287537 287418 310460 64639 307098 120099896 246174 311647 363509 310635 246244 310999 78966 140898 54296 361921 307398 309653 117020 303634 301334 295449 363460 310192 292406 64547 303882 114513 679566 24924 293024 100362710 79429 66018 687105 362648 81517 363616 266802 301737 100910984 315761 83502 310621 65201 24335 100360623 29417 83724 25627 65205 29543 85253 54281 25353 81707 116510 100360606 406163 29480 54289 54294 54293 54292 29650 54297 81663 498246 301088 246097 84583 100361166 117279 25385 59293 84022 246756 114705 246254 362021 289076 24264 81522 288924 59322 29542 498576 64363 29611 289878 161452 266715 29748 688297 365901 362550 306782 314212 100361818 282581 307401 24674 25400 24675 497961 364754 100360552 64303 25344 688319 687346 50664 309548 299809 65142 64511 100362554 302808 361171 25514 25318 170818 24888 304815 309399 309153 311401 308493 299617 362828 361601 170668 364052 305203 171109 63995 114856 297682 64551 360635 303605 290291 58840 192213 501146 312664 293847 361679 64535 246781 499349 289080 64314 310533 57027 84006 24596 29409 117089 360678 83765 450224 362548 294981 64019 306141 500873 301512 311598 117255 360820 24412 64053 60377 117284 24245 24246 29495 171140 83613 25252 58948 363174 64515 681185 297176 298594 114592 170845 308443 303037 306464 679342 296137 291441 24669 257649 257644 64041 287598 317252 307805 311191 114764 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 83836 295661 363198 304951 684439 289150 361416 304477 24874 29560 641452 297932 363131 298103 25700 246273 84489 29516 29757 289407 361992 83504 362802 65052 368044 296981 298451 299971 83615 170667 436582 498416 297566 312488 117596 94170 116664 366545 360406 300813 304758 100360427 114208 24790 499929 363445 25631 500715 24666 680111 361178 29357 84396 56761 500526 114486 297930 94203 300955 679934 296648 25589 81527 286928 114110 117542 29302 114111 89811 60352 362513 360457 296456 315189 310131 79249 310688 83785 79129 66021 294568 315348 314612 81679 246331 308666 362271 311163 313024 25414 58823 682937 170851 29622 295347 366061 310519 306152 64665 29613 83764 81634 293860 25576 56011 25577 313017 310806 83537 94338 102550344 58918 63879 307511 305539 296072 360903 64373 25507 116548 25320 24366 24367 685269 29434 59326 171337 361714 79239 114562 299236 499308 366205 29496 498596 432361 298787 307151 25193 313038 309626 363014 310258 303730 315136 501403 SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 97%10230696 Sensory perception of salty taste 25122 24768 24767 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-RNO-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 368001 296732 83833 361295 301020 361925 305589 361825 361711 292404 287876 293514 303518 297867 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%10228432 Activation of the phototransduction cascade 24400 307401 24717 85259 289878 363143 680149 688297 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-RNO-6803529.1 FGFR2 alternative splicing 689116 298075 289561 292778 64200 140931 500409 362950 307810 361655 83503 29497 117017 498109 363633 288588 29578 316123 690966 361365 PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 97%10231654 PKR-mediated signaling 54237 300955 362678 298693 25125 54287 691105 63880 499155 84351 24472 304859 312754 291978 24673 502320 303742 314172 114495 84472 311430 24672 29219 24842 24963 170897 295704 501552 117281 60460 311130 363006 25498 309361 24468 315648 117063 81635 309295 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-RNO-8853383.1 Lysosomal oligosaccharide catabolism 361378 310864 246136 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231342 RUNX3 regulates YAP1-mediated transcription 156726 363014 308582 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229824 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 294962 25736 307234 25262 25679 83579 59326 680149 81678 58979 64199 295347 83588 114117 24400 79218 81667 245986 25051 60449 246153 293508 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-RNO-156711.1 Polo-like kinase mediated events 25515 307511 308937 287101 KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 97%10230970 KEAP1-NFE2L2 pathway 117254 25233 24185 64862 502988 298576 287772 292766 29669 29668 29425 64156 100360846 117263 25581 308901 29666 303353 365388 117262 85492 287984 65138 94198 29673 50522 84006 29671 29670 29677 29676 29675 116643 84478 140639 192255 81827 83619 287280 303878 83806 311078 84027 361765 113894 100912032 301555 304127 29414 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231408 RHOU GTPase cycle 83709 300955 305614 64159 363509 50646 304546 81504 315686 29433 498798 29431 29432 292756 315840 301007 316369 56084 498282 64465 114559 366492 311030 310074 25513 291999 288093 305645 140922 678766 363445 360840 313934 54241 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%10230834 Regulation of FZD by ubiquitination 313589 282581 499918 299802 364754 500863 100912032 317674 50522 303412 64156 498997 498233 192255 64558 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%10228556 mRNA Capping 291534 689116 298075 289561 292778 288651 361580 294693 83503 117017 291703 313131 498109 363633 288588 293058 266713 316123 502227 690966 361365 84389 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME DATABASE ID RELEASE 97%10230596 IRF3-mediated induction of type I IFN 292892 299827 499069 498840 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10228632 L1CAM interactions 50687 24329 58960 289257 83510 29423 305614 64159 24586 314251 29302 50689 171574 296456 308458 29431 363875 246331 116563 116549 116743 24511 140670 116690 83841 54319 685269 116590 170851 83805 84393 65046 81521 25751 364686 25416 83800 81650 79114 54241 140694 GABA SYNTHESIS%REACTOME%R-RNO-888568.1 GABA synthesis 24380 24379 TRIGLYCERIDE CATABOLISM%REACTOME%R-RNO-163560.1 Triglyceride catabolism 300108 80841 24360 25440 25598 79131 25062 499570 140868 64822 SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies 314800 25014 117099 367112 295458 24450 65984 79238 REGULATION OF PYRUVATE METABOLISM%REACTOME%R-RNO-9861718.1 Regulation of pyruvate metabolism 497900 117098 290705 681913 100912032 296849 311254 50522 289950 298942 81654 64156 364686 81530 89813 288731 24533 298982 192255 83536 315949 246311 54705 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 97%10229830 Incretin synthesis, secretion, and inactivation 171101 25253 25040 25608 302813 266607 294075 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%10229276 Oncogene Induced Senescence 25261 24842 304063 24356 114483 116590 94201 292721 100912032 304798 50522 50689 64156 25164 494444 192255 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 97%10229080 Fc epsilon receptor (FCERI) signaling 25441 100361818 361400 305311 24605 24674 293621 24675 367901 81745 81504 24525 641452 295378 84477 81511 100360919 313845 25738 29337 29431 29432 366962 307366 363577 363875 84492 287772 25513 292766 81515 85243 29669 24244 29668 29425 64156 100360846 116725 117263 85385 314322 25581 311245 29666 303353 309295 365388 117262 85492 170911 25155 287984 313121 65138 363855 94198 25272 317676 29673 50522 25316 50689 29671 84351 25047 29670 24516 29677 29676 116667 29675 192255 81827 116554 287280 83806 311078 308267 361765 50658 116590 100912032 317546 81736 25493 309361 361831 303024 29748 83477 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 97%10229802 Mitotic Prophase 65158 308870 297522 498266 307947 315508 300149 689820 64528 307169 60336 24680 294429 287830 291874 362281 302783 113975 25203 316737 54237 24708 292085 25023 295692 287447 117021 24829 25437 306945 25515 362335 114087 24828 299204 366016 58958 317425 362557 50689 65274 113929 81754 245922 81738 685909 683983 680615 53372 116685 25497 365877 499974 362519 303175 116590 64627 690795 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229226 Chylomicron assembly 25081 25649 25506 25728 292697 54225 287276 310900 25080 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-RNO-351906.1 Apoptotic cleavage of cell adhesion proteins 292994 25402 306871 291755 84353 83502 83497 307562 304822 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 97%10230062 Zinc efflux and compartmentalization by the SLC30 family 58976 299903 294698 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 97%10229552 Role of LAT2 NTAL LAB on calcium mobilization 317676 84477 313845 100360919 170911 85385 25155 81745 25513 81515 85243 81504 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 97%10230838 SUMOylation of DNA methylation proteins 25573 301442 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME%R-RNO-140342.1 Apoptosis induced DNA fragmentation 24437 498072 680522 84359 201097 25402 684828 24917 291145 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-RNO-211945.1 Phase I - Functionalization of compounds 308190 24886 25527 25429 266761 301517 25426 25428 24172 79122 25427 29189 298079 313786 83724 25242 301252 310201 362782 266682 25750 25243 60351 246245 310848 29680 498999 80773 252931 362809 29539 24188 113902 312495 25035 114700 57300 171451 100145871 288517 29277 25279 296259 25086 25315 24296 291084 24297 29473 498940 499353 24307 25375 290623 304078 266674 310903 24894 24299 502969 84493 298423 24895 286904 313375 24306 171522 299566 503122 54246 171178 50549 308652 25256 308445 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 97%10229648 Miscellaneous substrates 266674 298423 288517 286904 24306 171522 299566 503122 50549 266682 24307 310848 308445 290623 252931 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-RNO-1268020.1 Mitochondrial protein import 171374 307081 498332 293991 63868 360826 25611 NURD COMPLEX ASSEMBLY%REACTOME%R-RNO-9937850.1 NuRD complex assembly 302783 24829 306945 303511 24828 307362 305501 293038 313048 300389 25573 291940 113984 117056 406195 680498 303060 301442 360804 685909 680615 365877 100362346 310614 303175 361724 297893 290669 362834 64520 117535 64627 690795 100359714 83712 50659 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230526 HS-GAG degradation 363513 691984 25216 171517 25615 116673 24771 25697 688293 317322 25236 64537 58920 360630 25592 368128 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-RNO-8875555.1 MET activates RAP1 and RAC1 295347 313388 54245 24553 363875 361388 24446 171337 287942 81504 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins 25290 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 97%10231440 LXRs regulate gene expression linked to cholesterol transport and efflux 58851 497941 365755 302711 313210 84578 PTK6 REGULATES CELL CYCLE%REACTOME%R-RNO-8849470.1 PTK6 Regulates Cell Cycle 83571 58919 366275 94201 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231396 RAC2 GTPase cycle 306152 361940 60431 29448 78967 307035 360509 290396 307562 366608 312108 295378 315992 29431 29432 305234 292756 308509 315121 29579 309696 63994 24511 362842 25513 300111 307459 60664 367902 317598 287537 304282 83709 679934 25437 170911 311647 286928 304546 304530 303653 360678 25097 310192 79249 79129 66021 315348 304109 308666 64465 64678 306400 313024 366492 116666 29528 308869 58823 310074 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%10230880 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 59294 289758 59102 361698 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-RNO-196843.1 Vitamin B2 (riboflavin) metabolism 362942 751787 25732 311536 85496 499328 ERK MAPK TARGETS%REACTOME%R-RNO-198753.1 ERK MAPK targets 501560 117269 24672 300980 117281 116590 50689 116663 363193 60587 24673 315648 81771 OPSINS%REACTOME DATABASE ID RELEASE 97%10229972 Opsins 89810 316259 192223 24717 306307 81644 498289 310869 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%10231778 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 81773 81774 245981 497860 81770 691531 64640 83789 81764 81765 641452 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 287119 29287 29286 315769 29285 124323 498402 29284 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 192255 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 100912032 300079 81920 292964 293418 81768 100361974 361831 81775 81776 362631 360572 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-RNO-937041.1 IKK complex recruitment mediated by RIP1 60350 29260 287545 100912032 364867 641452 448830 81920 50522 84351 64156 246240 309361 306886 361831 116725 311245 192255 363328 309295 60371 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-RNO-72649.1 Translation initiation complex formation 682390 81773 298700 81774 691947 299872 293427 288599 303831 288516 691531 299899 171350 83789 122799 29236 100361756 54318 29288 29287 29286 29285 124323 29284 296302 299027 29304 64156 25348 122772 65136 27139 294282 681429 117053 100362640 161477 94266 140654 140655 103689992 29258 117045 292762 362952 81775 81776 292148 300069 293484 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%10228482 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 170844 83830 171152 309638 289561 292778 288651 288533 373541 293345 294018 361580 303918 117526 294693 83503 117017 291703 498109 363633 287571 288588 266713 291773 316123 317256 502227 83828 690966 361365 81673 84389 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 97%10228896 FXIIa activates plasma kallikrein-kinin system 302783 300250 29681 24829 306945 24153 303175 24828 50692 306761 295703 64627 293118 117056 58940 680498 681544 25087 680615 365877 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9037629.1 Lewis blood group biosynthesis 366064 58924 407765 363040 288161 64445 296564 84597 MITOTIC G2-G2 M PHASES%REACTOME%R-RNO-453274.1 Mitotic G2-G2 M phases 311802 308768 306102 306599 366403 406168 361088 29753 81740 192228 399489 29479 363055 305467 294010 29214 500069 692032 301252 83572 290626 305882 309098 315423 361907 171566 682033 367153 295052 314787 361613 683722 361643 307511 360672 171102 300126 308064 100362495 362980 308937 287101 311573 293844 114494 310344 311529 362203 287929 246150 300963 308663 252921 64462 680991 60347 307347 25203 54237 25515 363174 29167 311191 266713 114764 58945 84389 83836 117103 64158 311546 117104 316531 85265 296554 29213 287772 292766 29669 29668 56010 29425 58822 64156 100360846 117263 25581 29666 304813 315648 303353 116670 365388 117262 85492 689296 287984 316602 65138 94198 29673 50522 29671 29670 299850 246294 29677 29676 29675 29489 24673 192255 25594 81827 24672 287280 24842 83806 311078 117281 361765 171103 100912032 85252 303024 299331 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-RNO-399954.1 Sema3A PAK dependent Axon repulsion 246331 289392 361597 29751 29433 309280 25150 29431 29432 312213 363875 299331 301252 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%10228786 Response to elevated platelet cytosolic Ca2+ 50693 682967 293886 94168 289316 308291 25673 24795 114095 311795 25651 84491 307396 246328 299909 25266 63836 293676 294643 113947 25373 364206 24244 24681 24648 24680 81803 81804 25023 29302 114111 89811 360457 59086 83785 81809 25717 302470 24446 24483 360918 360942 316531 363104 25524 24189 25087 81634 170924 293860 24366 24367 685269 60327 24936 85253 304805 25081 309609 25313 24482 24944 305021 56782 361196 84590 54249 363015 500152 24617 100359512 24791 24825 246358 498299 445442 686539 29583 24153 116510 363195 305679 307986 24786 116635 54404 312159 360950 287876 140656 296488 24614 24186 29186 24628 245955 315989 304983 24854 81814 295703 116662 54226 140594 309186 681544 293628 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME DATABASE ID RELEASE 97%10231454 Biosynthesis of DPAn-3-derived maresins 287454 25290 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 97%10230668 SHC-related events triggered by IGF1R 24483 24482 313845 85385 81504 25718 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231416 RHOV GTPase cycle 304007 83709 300955 305614 64159 307016 304546 315686 24852 29431 29432 292756 301007 316369 309168 171581 64465 114559 366492 310074 25513 171296 306417 305645 140922 362279 363445 54241 311721 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%10228588 Transport of Mature mRNA Derived from an Intronless Transcript 287830 291874 362281 689116 113975 298075 292085 295692 117021 362335 299256 366016 58958 289582 362557 65274 113929 297522 245922 81738 683983 53372 25497 59087 499974 690585 117045 304277 294429 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231434 Biosynthesis of D-series resolvins 29328 79242 299732 25290 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 97%10228932 Removal of aminoterminal propeptides from gamma-carboxylated proteins 25268 29243 260320 54281 25295 306608 24946 ETHANOL OXIDATION%REACTOME%R-RNO-71384.1 Ethanol oxidation 310903 29539 24188 100145871 24172 298079 296259 171178 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229030 Lectin pathway of complement activation 64023 64668 64459 299928 114091 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 307096 192242 498789 171516 25429 301517 25428 361266 83724 246211 291283 191574 364773 60351 498790 307092 ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%10231788 Error-prone mismatch repair hypermutates immunoglobulin genes 309812 316235 81685 288003 116468 81709 25737 288414 100912032 50522 305000 289758 64156 316344 89809 192255 313702 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly 287830 291874 362281 113975 685068 499391 292085 295692 117021 362335 84404 687711 363462 366016 58958 691231 65160 362557 65274 113929 297522 100362099 64301 681031 245922 81738 362688 683983 53372 316108 25497 310769 499974 84473 312947 171365 680737 294429 291794 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes 307347 83836 54237 64158 311802 25515 366403 316531 29753 81740 192228 299850 296554 29479 29213 363055 305467 294010 29489 29214 500069 83572 290626 305882 315423 367153 314787 117281 683722 360672 308064 29167 100362495 311573 293844 310344 56010 311529 58822 311191 114764 246150 58945 300963 299331 252921 64462 60347 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 24605 293621 170911 361388 81504 24525 313845 25738 84489 66017 25444 25622 29349 54250 25513 25317 29369 316213 29368 314850 116499 60662 60464 170583 85385 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-RNO-9009391.1 Extra-nuclear estrogen signaling 246332 24329 363425 24827 59325 24605 293621 170911 25233 25335 81745 24185 60421 81687 24525 25614 286924 81686 25149 29183 294515 25718 25686 24600 170897 25643 25522 116590 25513 83805 83571 25433 24244 64022 25313 24890 29414 29149 85252 298184 60664 306792 85385 299331 81664 170906 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-RNO-9027276.1 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 366508 29376 298947 497931 170911 361388 25513 81515 24514 85243 24335 TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling 688466 81859 687813 498803 83427 115771 114210 312937 64044 364386 63879 25625 313121 246244 83537 57027 641452 50522 84351 94338 289014 246294 266610 306886 117279 192255 246756 60371 363836 299827 287155 308267 360827 94193 100912032 317546 100362554 81920 60383 64156 309361 361831 311401 308493 362828 24835 309295 290864 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) 501560 117269 24672 501099 300980 117281 116590 117535 314910 50689 114090 116663 289014 363193 60587 24673 315648 315305 81771 PROTEASOME ASSEMBLY%REACTOME%R-RNO-9907900.1 Proteasome assembly 117262 85492 287984 65138 94198 29673 29671 29670 116722 29677 100361517 83499 29676 288455 29675 296651 81827 24968 24967 83806 311078 29614 287772 292766 29669 29668 29425 100360846 117263 25581 29666 291983 303353 365388 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%10230522 Resolution of Sister Chromatid Cohesion 298850 681050 83836 295661 363059 363198 304951 684439 289150 361416 304477 29564 65201 297522 83572 498265 315648 294429 287830 290577 304218 363481 313304 25203 63996 684771 54237 292085 305343 25515 287624 94266 309179 299147 252902 363193 312754 24673 29489 81738 362548 683983 29648 363174 24672 64515 681185 297176 298594 114592 170845 117281 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 85252 307805 81655 311191 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%10231720 Formation of the dystrophin-glycoprotein complex (DGC) 303468 432360 24907 362715 500364 305941 497892 25600 309816 298936 691517 307548 25592 66027 114489 299940 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-RNO-8963693.1 Aspartate and asparagine metabolism 79251 289727 85309 25721 362322 246266 24401 25612 367181 300384 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-RNO-453279.1 Mitotic G1 phase and G1 S transition 312046 313138 313479 299112 298098 292071 362385 312538 291927 307126 360621 304573 24185 684111 362304 301430 85241 399489 81758 25164 494444 499655 682033 366275 311860 295052 292787 171102 308937 83571 114494 305171 25255 266713 84389 117104 25233 362485 287772 292766 297893 81515 94201 83805 29669 29668 29425 100360427 64156 100360846 117263 25581 29666 315648 24514 680111 303353 361178 365388 58919 117262 85492 24708 294790 287984 65138 313048 94198 29673 50522 29671 29670 29677 64033 29676 29675 24673 25193 192255 81827 24672 287280 83806 311078 117281 114483 100912032 307585 29414 360908 301323 288532 316273 59102 295596 296178 29728 AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229698 Agmatine biosynthesis 298607 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%10228712 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 29597 25026 296648 81745 24185 25029 64199 305679 79218 315189 310131 245986 60449 293508 294962 66026 25521 24600 25725 58966 83579 64226 680149 58979 24244 114117 24400 56718 29156 81666 81667 29154 29699 81662 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 97%10228544 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 24297 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-RNO-6804114.1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 25203 54237 25737 313017 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-RNO-416476.1 G alpha (q) signalling events 25298 302378 25706 24605 25666 293621 170926 24179 497978 24816 24938 81504 25380 25107 24525 64199 25264 499913 24654 25229 313845 79218 24180 25265 379044 29180 288995 50672 378939 245986 25342 25238 691774 116677 60449 25031 64042 309207 53949 85240 308408 294962 29191 294394 499194 24260 25245 25593 83579 25513 680149 58979 24953 25007 81509 260319 59264 60337 170538 63887 114117 24400 25569 60664 81666 81667 767613 24680 29340 81662 83567 500157 171101 58949 289023 170911 24806 24808 292794 24247 192223 308118 317219 310192 25570 100360071 497196 64636 302619 299242 117264 57305 360579 29581 365228 29595 192205 192206 29597 25679 367901 314386 81678 60395 114098 114099 29636 116498 25087 294075 25652 24323 24326 24448 81668 25320 301086 690158 24418 24659 59301 25433 24414 25504 54248 25187 24221 78964 171371 81749 81771 688705 117269 192648 192649 24329 29254 84009 25637 25194 305795 29480 50689 54289 54294 54293 310327 498246 84583 100361166 59293 84022 25605 287910 501560 289076 24807 25723 25262 116590 366270 81821 366274 54226 140866 100361138 24889 66025 266607 116744 29413 29412 78976 500317 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 97%10228736 PKA-mediated phosphorylation of CREB 24244 302950 64532 25521 64508 25289 81636 25725 29699 29241 84420 293508 SIGNALING BY ERBB4%REACTOME%R-RNO-1236394.1 Signaling by ERBB4 29496 498596 432361 24329 59325 24605 293621 170911 300802 81504 311567 24525 297930 50522 313845 29192 292788 25489 192255 363014 81751 25513 289231 100912032 83805 25433 64022 25313 24890 64156 85385 24918 GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation 29718 64199 286924 24611 79218 81636 245986 60449 302950 294962 64532 25686 25289 25643 83579 81657 29241 680149 25743 84420 170847 58979 116649 114117 24400 50599 64508 81667 83633 116560 29713 81664 29712 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230704 CLEC7A (Dectin-1) induces NFAT activation 24244 361400 100361818 24674 24675 29748 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-RNO-6804759.1 Regulation of TP53 Activity through Association with Co-factors 246334 29414 171355 686781 24842 362675 25233 292064 24185 685474 311575 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME%R-RNO-937042.1 IRAK2 mediated activation of TAK1 complex 50522 64156 362418 308267 311245 313121 192255 100912032 317546 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-RNO-975138.1 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 64156 25742 81647 116725 314322 311245 315648 363328 309452 309295 81771 310877 117269 500133 60350 363520 29260 291921 64044 300447 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 448830 25493 312688 116663 54226 309361 60587 303024 IRS-MEDIATED SIGNALLING%REACTOME%R-RNO-112399.1 IRS-mediated signalling 29376 25443 170911 29348 25233 361388 81745 170579 170633 81504 84477 313845 363131 246273 84489 29516 361992 83504 65052 66017 25444 25622 29349 54250 25513 25317 29369 25022 85243 29368 314850 170700 25467 116499 60662 60464 170583 289625 25114 170582 79114 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 97%10231328 Invadopodia formation 57025 679837 303068 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%10228180 Transcriptional Regulation by TP53 311796 85482 305455 679203 192218 114212 290805 685055 310034 308755 306734 300711 25309 297627 295052 26195 360588 497856 171335 64012 654441 294800 303393 26198 84683 114494 498411 291787 100361529 116723 140583 94194 688386 681024 170824 140923 134478826 100188937 296648 24855 54322 360229 364298 315189 310131 25282 29445 140607 24398 102555170 690675 252934 288588 192268 266713 291773 316123 317256 502227 690966 361365 84389 170844 171152 309638 289561 292778 288651 288533 89812 373541 25233 293345 294018 361580 117526 294693 83503 117017 291703 498109 363633 287571 116484 362485 25576 689820 56011 297893 25577 313017 64156 315648 361374 362479 360471 64314 50522 24673 192255 114495 24672 117281 100912032 311575 117535 29414 113898 192350 59102 308986 25578 686781 306571 115771 58983 140942 81745 24185 363292 60445 29753 502988 292064 362110 282845 29338 290744 315210 685619 307511 25498 685474 299694 140908 306998 304798 83571 315427 116671 25203 54237 502894 171355 305837 683593 683469 24377 293625 114592 314862 310614 314621 361724 290669 362834 313777 24484 301513 291841 287249 316034 29619 306492 363603 83722 312227 117254 363221 58936 295707 288003 25405 311546 116468 314818 25737 81807 25533 288414 282844 305000 64525 292804 679713 246334 289372 65248 311613 56010 304758 83712 500715 81650 362272 64562 24942 313048 81785 362675 25520 116549 83803 24842 308869 310091 298514 64226 295357 373545 497672 297960 26954 64557 117044 117043 363924 362045 56718 303194 360776 315969 64046 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%10230366 Erythrocytes take up carbon dioxide and release oxygen 54231 304805 29242 171015 310218 365345 24440 360504 65207 24779 25240 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%10231268 Transcriptional regulation by RUNX3 301164 287772 292766 83805 29669 29668 361391 29425 64156 100360846 117263 25581 25631 29666 303353 365388 58919 303539 117262 85492 689844 310405 363287 679028 287984 65138 303101 94198 29673 50522 29671 29670 29677 59086 29676 29675 84353 192255 363014 312451 81827 24842 50554 83806 311078 156726 100912032 690516 161452 308582 ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors 24174 24175 25645 25083 24925 29413 29412 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%10229658 EGFR interacts with phospholipase C-gamma 25433 64022 25313 25738 24329 24827 59325 29183 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-RNO-983231.1 Factors involved in megakaryocyte development and platelet production 293502 192647 315740 89817 289168 500709 360509 366608 305987 314930 315992 117548 353302 293692 117550 363875 289397 293508 102554884 309523 64633 25521 64516 366960 313438 25725 500569 297893 361308 85248 171291 84393 366998 85471 313254 313388 192249 171041 303575 29699 24514 314473 54254 289309 64188 300158 113886 287624 294286 26956 117056 680498 691504 171120 114203 29300 25172 64465 25159 246209 171549 300266 316226 114124 303659 362825 499951 363288 314906 361512 312562 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME%R-RNO-9840309.1 Glycosphingolipid biosynthesis 310508 83626 81919 83505 58924 65196 64828 683713 365984 50555 407765 300129 362275 364901 64442 64445 63888 116740 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-RNO-8849471.1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 366275 362271 306400 24605 25414 360820 293621 54245 363875 25676 117273 24525 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-RNO-432047.1 Passive transport by Aquaporins 25386 65054 65133 286758 25293 367316 29172 29171 25480 25240 25241 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-RNO-500753.1 Pyrimidine biosynthesis 288051 65156 24240 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-RNO-6781823.1 Formation of TC-NER Pre-Incision Complex 366163 289561 245976 292778 288651 360915 314061 362479 497967 360471 361580 306274 294693 83503 117017 50522 363273 291703 498109 363633 192255 302502 362394 261736 363283 100912032 288588 64156 266713 246216 502227 361181 117039 690966 287367 361365 84389 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230002 NoRC negatively regulates rRNA expression 64627 302783 117056 690795 680498 24829 306945 303175 685909 24828 680615 365877 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%10229430 Degradation of beta-catenin by the destruction complex 81717 287772 292766 84424 29669 29382 29668 29425 64156 100360846 117263 25581 29666 315648 303353 365388 117262 85492 287984 65138 100360606 94198 29673 50522 24205 309179 29671 29670 299147 79257 29677 363193 312754 29676 501584 29675 24673 113927 84353 103691373 679110 192255 25565 312451 81827 24672 287280 83806 311078 84027 117281 361765 100912032 161452 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-RNO-162699.1 Synthesis of dolichyl-phosphate mannose 29640 296394 502017 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-RNO-210455.1 Astrocytic Glutamate-Glutamine Uptake And Metabolism 29482 24957 170567 29483 DAG1 GLYCOSYLATIONS%REACTOME%R-RNO-8931838.1 DAG1 glycosylations 316091 291212 306549 84430 688673 313139 362567 361368 311202 362520 299841 493574 257647 114489 308390 293667 140568 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 97%10230944 Dectin-2 family 25150 362432 25441 450223 29337 25155 81515 MITOCHONDRIAL TRANSLATION%REACTOME DATABASE ID RELEASE 97%10230892 Mitochondrial translation 303746 295238 293054 309176 298517 26200 293754 297799 361883 311903 363023 301552 299628 497876 686234 26197 26196 683519 315141 288916 294230 309140 100363539 360594 500199 299938 292758 293453 287962 295224 296551 171061 292244 363646 26195 689432 26194 361473 361005 310653 362216 26199 297601 56281 309440 287656 26198 297459 301250 301371 364656 287302 26193 293666 26192 114017 296134 303685 64360 113958 294767 684304 680747 301352 290850 26203 297372 26202 301240 498406 26201 FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling 24605 66017 293621 25444 25622 29349 54250 25317 29369 316213 81504 314850 29368 24525 116499 60662 60464 313845 170583 84489 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%10231774 Assembly of the 9+2 motile cilia 100360427 362675 498102 299979 298555 313993 361178 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME DATABASE ID RELEASE 97%10231512 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 65134 25437 58857 64001 24451 54226 64667 24686 65183 298689 80881 116470 24803 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%10228980 Cytoprotection by HMOX1 296732 94194 363026 688386 681024 100188937 54322 360229 84578 25282 83724 25309 497991 29445 24565 24186 312947 24440 311545 360504 26195 365755 302711 171335 654441 303393 102555170 26198 690675 84683 24360 116599 24451 252934 79239 25747 292737 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%10229734 Class C 3 (Metabotropic glutamate pheromone receptors) 170634 78979 690448 24247 554302 500089 81672 100310876 60590 294394 29407 78981 78980 24418 78983 81657 78985 24417 24419 24414 680188 100270683 24416 24415 246219 83633 502757 500091 689869 500101 APAP ADME%REACTOME DATABASE ID RELEASE 97%10228906 APAP ADME 24902 25086 291394 83783 156275 290681 29566 24426 360268 361510 312382 24565 116721 170924 25303 24912 116632 116631 300981 24861 113992 140668 408206 116568 25260 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME DATABASE ID RELEASE 97%10228334 Detoxification of Reactive Oxygen Species 294744 117254 259233 171562 64371 24787 24786 116484 24426 25309 79129 66021 29338 24404 50551 79462 25506 25352 85431 94167 690675 84485 297998 113898 64317 24248 113919 298376 IGF1R SIGNALING CASCADE%REACTOME%R-RNO-2428924.1 IGF1R signaling cascade 24483 29376 25443 170911 29348 25233 361388 81745 170579 170633 81504 84477 313845 363131 246273 84489 29516 25718 361992 83504 65052 66017 25444 25622 29349 54250 25513 25317 29369 25022 85243 29368 314850 170700 25467 116499 60662 60464 170583 24482 289625 25114 170582 85385 79114 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%10231130 TP53 Regulates Transcription of Cell Death Genes 308986 24484 293625 170824 140923 134478826 58983 300711 24942 25533 64314 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%10228412 Dimerization of procaspase-8 266610 306886 64044 246097 117279 25385 246756 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%10228534 RNA Polymerase III Transcription Initiation 246299 301246 685539 294687 114205 311487 310685 361102 117526 685465 690254 316810 83503 306012 304204 362537 306542 498109 362095 313914 171068 690966 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450604.1 KSRP (KHSRP) binds and destabilizes mRNA 25578 294975 300045 307850 24185 679140 366017 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231402 RHOJ GTPase cycle 312108 307459 299145 306400 362842 310192 311647 310074 25513 299012 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231412 RHOBTB GTPase Cycle 315265 308968 306004 117259 360915 297406 361813 114612 302855 315840 365407 301252 81634 313216 261736 81818 25537 171115 81822 299809 301555 360596 140922 299331 117039 300838 114562 309722 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-RNO-111448.1 Activation of NOXA and translocation to mitochondria 492821 SIGNALING BY NTRK3 (TRKC)%REACTOME%R-RNO-9034015.1 Signaling by NTRK3 (TRKC) 29613 81737 25738 83805 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%10230860 B-WICH complex positively regulates rRNA expression 306817 302783 303539 24829 306945 65261 24828 306274 117526 301164 83503 498109 117056 680498 685909 287876 680615 365877 301246 361784 84027 360893 361420 303175 368002 313245 680493 64627 362728 317399 83582 690795 690450 83581 60571 690966 84486 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229930 Adrenaline,noradrenaline inhibits insulin secretion 294962 64532 25686 25289 83579 680149 58979 64199 114117 24175 24400 79218 25083 81667 245986 60449 81664 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%10230554 Synthesis of IPs in the ER lumen 29688 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%10231560 Sealing of the nuclear envelope (NE) by ESCRT-III 500929 246772 282834 364419 64158 500377 361916 307833 246118 365191 500363 300218 498736 316531 363720 307351 287873 291081 313478 679312 296554 29213 362700 679886 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 97%10229728 Chemokine receptors bind chemokines 84348 246358 84475 305236 171551 360918 116637 685243 688605 316019 29385 282832 363682 81503 301066 362505 298006 25542 287673 246759 29397 301086 308163 117518 498335 24772 117027 114105 60628 29538 117029 171056 287561 245920 287562 89808 171371 60665 29363 497942 54258 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 97%10230364 ER-Phagosome pathway 64630 24968 24967 24223 85492 29614 24974 29528 680842 83730 499400 29669 24988 29673 29668 29671 29670 24750 100360846 29676 29666 365527 291983 29468 MTOR SIGNALLING%REACTOME%R-RNO-165159.1 MTOR signalling 303605 290291 64562 24855 501146 25233 24185 60445 25520 83803 25639 292887 308869 310091 298514 64226 24644 295357 56011 314621 373545 116636 25435 297960 65248 26954 117044 117043 117045 29414 83840 29304 362045 56718 360776 24666 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%10230494 Elastic fibre formation 311061 29302 296456 59086 81809 292734 25717 362800 59107 24914 59106 24511 83838 29158 25043 85272 29373 313662 500245 290350 54281 309380 252835 293677 83727 315714 HISTIDINE CATABOLISM%REACTOME%R-RNO-70921.1 Histidine catabolism 29301 293871 685999 309150 89833 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-RNO-181438.1 Toll Like Receptor 2 (TLR2) Cascade 680127 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 97%10229604 Vitamin D (calciferol) metabolism 25573 362827 24873 29216 80848 25279 63865 499417 114700 REGULATION OF INSULIN SECRETION%REACTOME%R-RNO-422356.1 Regulation of insulin secretion 25736 25679 81678 64199 24654 24175 79218 25083 245986 60449 246153 293508 85240 294962 64532 25297 307234 25686 25289 25262 300992 116600 83579 59326 680149 25559 83535 58979 24778 24239 295347 83588 114117 24400 114024 113976 81666 81667 266607 25051 24680 81662 81664 25398 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-RNO-429958.1 mRNA decay by 3' to 5' exoribonuclease 363064 294975 293408 360629 300045 294595 307850 266605 679140 366017 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 97%10228864 APC C-mediated degradation of cell cycle proteins 366381 292588 293155 296368 361389 288671 290875 305420 360643 295052 287772 292766 29669 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 117262 25203 64193 85492 54237 24708 294790 310806 292263 25515 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 64515 287280 297176 83806 311078 114592 361765 100912032 361831 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%10229544 Formation of the beta-catenin:TCF transactivating complex 312451 310704 300837 102550344 297893 362093 29417 84424 301965 300673 304794 84353 691857 161452 25565 295251 304832 290829 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-RNO-427975.1 Proton oligopeptide cotransporters 246239 117261 246280 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%10228614 GRB2 events in EGFR signaling 25433 64022 25313 313845 24329 24827 24605 59325 29183 293621 81504 24525 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-RNO-422085.1 Synthesis, secretion, and deacylation of Ghrelin 293142 24482 301265 25608 306515 266758 25204 24506 24391 24505 59301 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-RNO-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic 503165 60355 363059 293502 315740 289168 79117 252889 117548 353302 117550 60384 289397 300674 309523 246310 361308 85248 171291 84393 313254 84599 360953 171041 303575 362162 314473 289309 361207 290659 300158 113886 297428 287624 361577 304290 294286 309451 81754 300888 140932 79120 64310 114023 304978 246209 171549 140940 140673 65165 316226 303659 296750 363288 314906 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%10230254 TRAF6 mediated IRF7 activation 292892 293624 AMINO ACID CONJUGATION%REACTOME%R-RNO-156587.1 Amino Acid conjugation 293779 353317 246263 688536 361637 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231646 Transcriptional and post-translational regulation of MITF-M expression and activity 690660 116483 306804 117516 287191 290868 29361 25573 50689 292028 170577 301442 291624 60427 84027 116590 309757 288480 29414 85252 353305 64030 25094 289352 81771 MRNA 3'-END PROCESSING%REACTOME%R-RNO-72187.1 mRNA 3'-end processing 366693 308968 689116 687575 298075 289561 292778 117259 305586 311670 299256 299811 83503 117017 289582 498109 302969 363633 494445 29578 81781 300996 313030 24668 29667 313035 79256 292019 64200 362687 499314 319110 361808 291295 317612 117280 117282 64156 689890 500538 361814 291794 362361 307474 84401 687711 116697 288701 680891 50522 363005 683927 245957 100362099 304859 681031 100361269 302855 365407 500242 192246 314417 308650 192255 25594 362152 303607 686980 80846 171365 313583 680737 305479 311166 140931 361859 290614 100912032 287768 29497 299620 295270 304277 290666 288588 291877 64510 316123 361542 690966 84486 292729 361365 361788 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%10228202 Cellular responses to stimuli 361940 25614 25309 291671 79462 26195 58966 171335 654441 303393 26198 84683 94194 688386 681024 100188937 54322 360229 303333 25282 29445 102555170 690675 252934 498013 29597 25400 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 24565 298282 25747 296732 84006 24600 113894 113898 25026 25029 24245 24246 29338 25506 24413 171140 308901 25617 116685 24468 25672 117254 316101 24874 81807 29560 114490 64345 641452 64525 29452 54702 85265 308457 297932 298103 289407 362802 54318 368044 298451 299971 24511 170667 436582 297566 296302 312488 117596 94170 116664 366545 25081 299027 299850 29489 24186 311545 81655 24248 64046 89842 85482 192218 29564 297522 294010 300711 25164 494444 365057 294917 66026 311860 295052 64012 114494 296648 29302 24472 296456 315189 310131 314638 79129 66021 304962 303016 24963 60460 29167 140734 81920 361831 58945 54225 24697 25233 64862 116484 290232 297758 500054 307798 307861 299121 309757 64156 314322 315648 309295 24208 81771 117269 29260 24708 363855 25272 50522 50689 84351 24516 289014 252902 315994 84478 140639 192255 497991 114495 501560 24672 116554 83619 287280 117281 361765 50658 116590 100912032 81736 448830 25493 24890 29414 85252 309361 689415 299331 117038 59102 307480 27137 298203 114766 363026 29702 81745 24185 84578 64199 361810 29753 500843 79218 100362347 502988 24627 360497 362573 24426 362441 690751 360969 245986 84428 303185 301252 305464 363138 294515 60449 304410 293508 291145 304569 362809 302935 260321 294962 94165 24437 25154 363849 25521 680522 201097 298576 365755 302711 84017 117062 25725 684828 83579 680149 58979 304798 24244 83571 114117 24400 81666 81667 29699 81662 24404 24253 50551 303878 286899 362293 25352 65028 24356 85431 293524 292721 94167 25420 84485 307997 304127 297998 297994 311427 690038 64317 266759 293103 79245 288444 113919 307133 113906 298376 294744 25261 116456 300721 259233 81800 171562 500907 117104 304063 366734 64371 171361 29734 192277 83724 25242 24440 360504 287772 292766 94201 29669 24360 29668 116599 24451 79239 29425 100360846 292737 29156 83712 117263 29154 25581 29666 303353 365388 294429 287830 291874 362281 302783 117262 113975 85492 292085 295692 24829 117021 306945 362335 287984 24828 65138 366016 58958 313048 94198 305679 293615 29673 362557 65274 24787 29671 113929 29670 24786 117056 29677 680498 363630 245922 29676 81738 29675 116643 307151 685909 683983 313038 53372 680615 309626 25497 363014 365877 499974 310258 56611 81827 303730 312947 315136 24842 83806 311078 292887 308869 84027 310091 298514 501403 303175 64226 295357 114483 688041 500336 301555 297960 26954 117044 117043 64627 362045 690795 56718 360776 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229630 DAP12 signaling 361537 24223 24605 293621 170911 25155 29684 25513 367901 25110 85243 81504 24525 295378 25150 313050 81511 313845 25738 29337 366962 85385 363875 24934 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 29386 297893 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229894 Prostanoid ligand receptors 25652 498475 292661 81752 63889 309212 84023 25637 24816 24929 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-RNO-1799339.1 SRP-dependent cotranslational protein targeting to membrane 81773 81774 245981 497860 81770 291685 691531 64640 83789 81764 690345 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 116650 29285 124323 29284 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 97%10230616 Hyaluronan metabolism 363103 25406 282821 500052 25694 300757 24782 64152 404783 300993 367166 24434 116721 266805 294673 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism 25331 363285 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-RNO-166020.1 Transfer of LPS from LBP carrier to CD14 60350 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 97%10230568 Signaling by NOTCH 29146 25578 24329 56761 300802 24185 304591 311567 50522 84006 29192 29650 292788 311332 84010 192255 81751 289231 291999 100912032 65165 25313 64156 304815 500538 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-RNO-1606322.1 ZBP1(DAI) mediated induction of type I IFNs 25493 292892 84351 304859 309361 301059 287707 309452 309295 81736 COBALAMIN (CBL) METABOLISM%REACTOME%R-RNO-9759218.1 Cobalamin (Cbl) metabolism 290947 81522 313520 362134 291939 SIGNALLING TO ERKS%REACTOME%R-RNO-187687.1 Signalling to ERKs 58960 24605 293621 56011 170851 116590 287942 81504 314850 114486 24525 29622 295347 50689 313845 289014 59109 310738 54245 85385 315994 116478 314612 TRANSPORT AND METABOLISM OF PAPS%REACTOME DATABASE ID RELEASE 97%10229212 Transport and metabolism of PAPS 306866 295443 360670 117267 294103 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%10230642 NOTCH3 Activation and Transmission of Signal to the Nucleus 81751 29146 24329 56761 300802 289231 291999 100912032 50522 25313 29192 29650 64156 292788 311332 84010 500538 192255 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%10230674 The retinoid cycle in cones (daylight vision) 89810 24711 302425 81644 313689 293049 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 97%10231042 Negative regulation of MAPK pathway 63995 114856 297682 58960 24605 293621 293847 361679 246781 114486 24525 687346 50522 50689 309179 60352 170577 299147 363193 312754 24673 192255 65179 24672 29542 300980 117281 64363 56011 116590 170851 100912032 116663 64156 60587 24703 315648 305203 171109 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%10228336 Cellular response to chemical stress 363026 24185 84578 502988 24426 25309 29338 79462 25506 26195 365755 298576 302711 171335 654441 303393 26198 84683 308901 94194 688386 681024 100188937 54322 360229 25282 79129 66021 29445 24404 50551 303878 25352 85431 102555170 94167 690675 84485 304127 297998 252934 64317 113919 298376 294744 117254 259233 171562 25233 64371 64862 116484 83724 24565 24440 360504 287772 292766 29669 29668 24360 116599 24451 29425 79239 64156 100360846 25747 292737 117263 25581 29666 303353 365388 296732 117262 85492 287984 65138 94198 29673 50522 84006 24787 29671 29670 24786 29677 29676 29675 116643 84478 140639 497991 192255 24186 312947 81827 83619 311545 287280 83806 311078 84027 361765 113894 100912032 301555 29414 113898 24248 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 97%10228682 G alpha (i) signalling events 81645 287730 688605 689936 29385 282832 25340 554302 29141 60590 292409 64042 246759 29397 25111 292419 25323 81509 63887 297795 767613 25689 29363 54258 84348 24232 305236 50577 171551 24929 290493 117549 24247 316259 81503 29256 498289 362505 497196 100911796 81657 353250 308163 84007 117027 57302 89810 100270683 360579 171056 306307 25555 29238 89808 81644 689869 29237 365901 29235 170634 29234 84475 29471 171044 360918 24797 24677 25524 25083 81672 25087 294807 29335 690158 24659 266997 24417 83805 24419 24772 114105 60628 24416 24415 309212 83633 500091 315648 497942 246358 116637 25516 408199 310444 25075 363193 192646 24673 501177 500089 100310876 363143 301066 29481 679957 287910 298006 24672 29407 78981 78980 117281 78983 116590 362454 78985 498335 29538 117029 54226 245920 83518 246219 60665 679975 54305 78979 24179 259224 259222 24613 25380 64199 24654 24174 286924 690448 83506 24175 24611 79218 360616 24627 363682 24626 25638 81636 245986 25238 24668 60449 25031 293508 64803 302950 85240 24182 294962 25033 64532 25521 287673 25686 25289 113959 25643 24717 25601 25245 25725 63843 83579 29241 25248 680149 170704 84420 58979 140908 24244 170538 680188 114117 24400 64508 58812 81742 25050 81666 24604 81667 24681 502757 29699 171104 24680 171108 81662 500101 81664 83567 60341 29691 310869 29290 54296 362477 308118 406163 29480 54289 54294 54293 54292 54297 498246 301088 100361166 59293 114705 246254 362021 289076 66025 306792 60399 116744 29415 500317 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%10231344 RUNX3 regulates p14-ARF 58919 361391 59086 156726 363287 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-RNO-9634635.1 Estrogen-stimulated signaling through PRKCZ 24605 293621 25522 81745 116590 24525 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%10228976 Telomere Maintenance 306264 288003 116468 290805 25737 288414 85241 287432 297483 170944 499709 367645 308755 691534 301965 362288 287273 303238 290232 297758 294025 500054 307798 307861 364996 59294 84490 295052 171121 114494 289758 309144 301323 89809 59102 361698 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228236 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 24638 24640 54283 117276 DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions 315615 171119 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190242.1 FGFR1 ligand binding and activation 83504 66017 25444 25443 29349 54250 25317 170579 170633 29368 170700 116499 60662 170583 79114 83823 29610 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-RNO-6785807.1 Interleukin-4 and Interleukin-13 signaling 500616 362862 25084 100361294 25125 25326 24514 287287 116553 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231574 RND3 GTPase cycle 295588 310999 305605 310090 83764 302855 306871 291755 301007 293497 362938 362859 315829 361029 306400 287543 366492 289229 25306 89816 498331 310074 25513 299012 24264 312667 192207 305645 140922 300838 29745 304893 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%10230090 RHO GTPases activate PAKs 29433 24244 293860 64465 29431 29432 288057 363875 304813 116670 25594 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-RNO-168164.1 Toll Like Receptor 3 (TLR3) Cascade 292892 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 293624 291921 64044 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 24673 315599 500900 315994 192255 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-RNO-433692.1 Proton-coupled monocarboxylate transport 25246 114511 29735 65200 80878 25027 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-RNO-110331.1 Cleavage of the damaged purine 307798 307861 302783 24829 306945 303175 24828 170841 81528 64627 690795 685909 680615 290232 297758 365877 500054 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 97%10228918 Recycling of bile acids and salts 300790 29725 502348 24777 79111 25440 140668 83724 58978 303879 170698 83569 60351 24186 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-RNO-6806667.1 Metabolism of fat-soluble vitamins 25571 307096 25216 309004 313706 300027 29216 361266 296972 364773 498790 399684 691984 171517 25615 498789 24710 25703 24856 25702 25680 192259 116673 171516 24771 299858 362558 25081 64047 317322 24539 25236 315644 25649 58920 314941 25728 25592 25056 292697 55939 54225 291283 191574 307092 25080 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-RNO-5668599.1 RHO GTPases Activate NADPH Oxidases 65052 25023 25522 94195 116590 292279 302976 170538 50689 311793 363131 114243 363875 116547 24680 79129 66021 ASPIRIN ADME%REACTOME%R-RNO-9749641.1 Aspirin ADME 25246 29277 25086 63867 688536 498940 293779 286989 353317 140860 266682 246263 24186 361637 252931 25303 89776 171522 266685 113902 501907 24861 286954 113992 140668 25027 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-RNO-2046105.1 Linoleic acid (LA) metabolism 498728 84575 171400 25288 83512 363516 309449 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 97%10230452 Acyl chain remodelling of PC 362039 690610 691905 29354 24913 29692 295631 298579 289733 29526 192259 29359 314075 297694 360426 296048 311341 362434 313997 361467 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME%R-RNO-5654228.1 Phospholipase C-mediated cascade; FGFR4 66017 25444 29349 54250 25317 29369 29368 170700 116499 60464 170583 25738 289625 25114 170582 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%10230030 mRNA decay by 5' to 3' exoribonuclease 364624 500305 361109 297455 500988 361399 361736 498934 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 97%10228934 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 25268 29243 260320 54281 25295 306608 81716 24946 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-RNO-9032500.1 Activated NTRK2 signals through FYN 25150 315992 25054 24225 363875 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228240 Glycogen synthesis 690987 309513 81675 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-RNO-9839406.1 TGFBR3 regulates activin signaling 29200 29263 24504 29610 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%10229924 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 24654 85240 81666 266607 81662 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 97%10229228 Plasma lipoprotein assembly 25506 24153 313210 25081 83470 25649 25728 303796 25292 292697 680551 54225 287276 310900 293508 25080 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229392 Androgen biosynthesis 305291 25146 360348 84013 24950 64677 25329 116700 24470 117182 682974 29632 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-RNO-1614558.1 Degradation of cysteine and homocysteine 691966 79462 192172 25274 309732 292710 81718 367181 170943 83586 25256 24962 81805 MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228628 MAPK1 (ERK2) activation 58960 25622 100361294 116590 24514 24498 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME DATABASE ID RELEASE 97%10228360 Ribosomal scanning and start codon recognition 682390 81773 298700 81774 691947 299872 293427 288599 303831 288516 691531 299899 83789 122799 29236 100361756 54318 29288 29287 29286 29285 124323 29284 296302 299027 29304 64156 25348 122772 65136 27139 294282 681429 117053 100362640 161477 94266 140654 140655 103689992 29258 117045 292762 362952 81775 81776 108348073 292148 300069 293484 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 97%10228542 Cytochrome P450 - arranged by substrate type 308190 24886 25527 25429 266761 301517 25426 25428 79122 25427 29189 313786 83724 25242 362782 266682 25243 60351 310848 29680 498999 252931 312495 114700 288517 29277 25279 25086 24296 24297 499353 24307 290623 266674 24894 24299 502969 298423 24895 286904 313375 24306 171522 299566 503122 54246 171178 50549 308445 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-RNO-9758274.1 Regulation of NF-kappa B signaling 291921 64044 291861 100912032 50522 312688 84351 64156 309361 315599 500900 311245 192255 309295 REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction 289777 362960 500052 499870 498265 292767 24936 366174 680264 689349 100910102 680912 290989 362623 499152 100362588 24163 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 97%10229596 Hypusinylation 288923 310261 287444 314644 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%10230788 Attenuation phase 362809 260321 24472 24963 286899 24468 60460 79245 299331 301252 NTRK2 ACTIVATES RAC1%REACTOME%R-RNO-9032759.1 NTRK2 activates RAC1 25150 315992 25054 24225 363875 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%10230202 The NLRP1 inflammasome 360557 24888 P75NTR REGULATES AXONOGENESIS%REACTOME%R-RNO-193697.1 p75NTR regulates axonogenesis 317598 24596 29409 310738 360678 83765 450224 117273 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation 117103 29448 58983 25533 65158 84589 266688 50645 501854 299799 50866 64633 94197 315668 288700 365793 84590 500249 363123 25532 25531 24942 84379 25530 81754 79434 307039 81756 299156 310632 171058 360571 305853 500088 171122 100364984 503269 252916 81755 85237 317580 171111 246324 367242 689377 140665 309649 81830 288779 367915 287709 689102 FRS2-MEDIATED ACTIVATION%REACTOME%R-RNO-170968.1 Frs2-mediated activation 295347 50689 59109 58960 310738 170851 56011 116590 114486 287942 314850 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-RNO-216083.1 Integrin cell surface interactions 360606 311061 499431 25246 170921 445442 313785 116640 25406 81682 29583 306628 83502 29302 296456 290905 309684 25361 362800 54266 308995 298702 24511 310683 315509 24366 24367 25118 685269 64350 25304 116479 25713 83727 83577 25353 360647 619374 29364 499271 25464 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%10229570 Fibronectin matrix formation 24511 81613 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-RNO-6796648.1 TP53 Regulates Transcription of DNA Repair Genes 311796 289561 305455 292778 679203 288651 362479 361580 81807 294693 83503 117017 64525 291703 498109 363633 81785 362110 683469 306998 304758 288588 266713 316123 192350 502227 500715 690966 361365 84389 CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence 25261 85482 192218 304063 366381 292588 293155 296368 361389 288671 290875 116484 362485 305420 300711 360643 25164 494444 290232 365057 294917 297758 500054 291145 307798 304569 302935 307861 94165 24437 363849 680522 295052 201097 84017 117062 684828 64012 94201 83571 304798 114494 64156 83712 314322 81771 117269 302783 24708 24829 306945 24828 363855 313048 25272 50522 50689 24516 117056 289014 680498 363630 307151 685909 313038 680615 315994 192255 116685 309626 365877 114495 310258 501560 303730 315136 24253 116554 24842 501403 24356 303175 50658 116590 114483 688041 292721 100912032 64627 690795 361831 64046 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation 89820 299521 302931 102553119 83789 171361 689197 361664 316976 24244 29565 24468 292845 CHAHP COMPLEX ASSEMBLY%REACTOME%R-RNO-9940465.1 ChAHP complex assembly 117535 360609 297093 64622 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 97%10230190 Deubiquitination 316794 688466 50557 115771 312937 298534 301164 288306 361190 100361658 313427 310960 308896 302488 290652 500572 408217 310306 363164 361495 304150 302415 307905 499801 362636 56084 314453 60331 25490 297593 171329 311856 293705 288482 295052 363084 298576 315911 360763 315639 171102 304798 114494 85471 289468 298012 498560 293494 315723 29545 683630 360853 65137 304298 362704 316440 306257 54237 311026 362258 291737 315523 296084 85423 114558 24205 498798 79257 361381 83529 29591 83532 64515 83531 50554 266601 311030 81516 304017 25387 25671 24577 361831 100362121 296121 171152 293345 29560 56816 306886 25388 25700 24255 60371 29240 287772 292766 362788 117273 29669 29668 29425 64156 100360846 304579 309153 117263 363445 25581 25631 311245 29666 303353 309295 365388 64646 29357 24208 502125 500133 303539 117262 85492 294790 361925 287984 313121 360471 286761 24828 362491 140593 65138 100360606 363982 94198 29673 50522 29671 29670 287362 29677 29676 684097 29675 116643 680615 287876 84478 192255 365877 29134 81827 24842 83806 171565 311078 308051 100912032 497672 315134 360990 64557 292876 25493 24890 312688 361749 26295 362414 290997 24919 290631 290864 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 97%10231066 Josephin domain DUBs 292876 50522 56816 64156 116643 192255 298012 100912032 361381 60331 315134 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229624 PECAM1 interactions 25150 313050 25738 296456 25622 29583 116689 81515 54259 83805 29302 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 97%10229032 Creation of C4 and C2 activators 25419 64023 100360919 64668 298566 312705 64459 192262 299928 29687 114091 362634 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 97%10228152 Orc1 removal from chromatin 313138 313479 117262 85492 292071 294790 312538 291927 287984 360621 65138 362304 301430 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 295052 311078 287772 292766 100912032 29669 29668 114494 29425 64156 100360846 117263 25581 29666 288532 316273 295596 303353 365388 296178 29728 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME DATABASE ID RELEASE 97%10230934 Assembly of the 9+0 primary cilium 311802 289168 366403 29753 81740 192228 29479 363055 305467 363272 294010 29214 114089 500069 83572 290626 305882 315423 367153 314787 24717 683722 360672 308064 85248 100362495 311573 293844 310344 311529 246150 300963 252921 64462 83567 60347 307347 54237 25515 25273 25411 314961 85258 24650 679894 308443 81830 29167 140734 311191 114764 58945 304007 287612 83836 117103 65209 64158 171044 307724 100362124 316531 305349 303968 295654 116475 296554 64632 29213 288585 60627 300675 365153 312651 298767 503018 100910342 171455 116654 685284 113948 362265 24818 50556 500571 362553 365770 288305 245709 363286 300062 294864 363544 500832 296618 316102 295230 287541 29374 498095 373066 299246 311456 295106 170714 362142 363760 313365 311123 299809 314523 361930 500086 299209 499814 689779 366872 252881 308923 363126 300880 303915 56010 680407 287383 58822 305287 361789 293148 296136 313170 287836 117515 361727 64664 266809 309486 367714 299850 309451 29489 79120 117281 29885 299331 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%10231752 Circadian clock 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 63840 78962 192255 287422 81827 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 97%10228374 Formation of a pool of free 40S subunits 682390 81773 298700 81774 691947 245981 299872 497860 81770 293427 288516 691531 299899 64640 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 29285 124323 29284 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 292762 100361974 362952 81775 81776 362631 292148 300069 293484 360572 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230486 Mitochondrial biogenesis 245958 140608 300677 171082 306840 94271 24399 245965 171069 29754 362749 641434 690441 171375 690675 192241 293615 65262 361596 171374 24787 26197 26196 25309 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%10231340 RUNX3 regulates WNT signaling 312451 156726 84353 161452 FMO OXIDISES NUCLEOPHILES%REACTOME%R-RNO-217271.1 FMO oxidises nucleophiles 25256 84493 246245 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-RNO-2173789.1 TGF-beta receptor signaling activates SMADs 311061 29302 50522 296456 59086 500985 81809 192255 297699 313477 81810 25490 292734 25717 29591 362800 59107 59106 50554 25639 287155 24511 83837 83838 81516 100912032 64156 54281 25631 29357 29610 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-RNO-69601.1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 140583 58936 117262 85492 114212 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 113927 192255 81827 287280 83806 311078 84027 361765 287772 171102 292766 100912032 29669 29668 29425 58822 64156 100360846 303024 117263 25581 29666 303353 365388 CA ACTIVATED K+ CHANNELS%REACTOME%R-RNO-1296052.1 Ca activated K+ channels 54262 54261 294961 54263 310303 66016 83731 29747 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%10231326 RUNX1 regulates transcription of genes involved in BCR signaling 50662 361391 500453 361944 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-RNO-75876.1 Synthesis of very long-chain fatty acyl-CoAs 364134 361895 498728 191576 25288 301120 117243 309449 300783 114024 113976 171410 680115 171402 84013 171400 94340 117182 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-RNO-8874211.1 CREB3 factors activate genes 314638 89842 303016 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange 140583 85482 192218 360588 497856 290805 64012 499870 497672 64557 305000 308755 306734 303194 291787 300711 499966 64046 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%10228742 RNA Polymerase II Transcription Elongation 689116 311796 298075 289561 305455 292778 679203 288651 266787 362479 361580 81807 294693 83503 117017 64525 291703 498109 363064 363633 293184 361531 81785 303281 301119 362110 303132 683469 114510 291705 300837 306261 304758 288588 266713 316123 502227 500715 690966 361365 304832 84389 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 97%10230476 PI and PC transport between ER and Golgi membranes 114561 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-RNO-3108214.1 SUMOylation of DNA damage response and repair proteins 690244 297561 25573 297522 308755 301442 499417 299957 690043 313961 691688 363269 361645 293528 102551929 293967 25591 287662 308669 294429 287830 291874 362827 362281 313304 113975 63996 292085 295692 117021 362335 366016 58958 300772 362557 65274 113929 245922 83422 81738 307151 683983 313038 53372 309626 25497 499974 310258 303730 501403 497672 SEROTONIN RECEPTORS%REACTOME%R-RNO-390666.1 Serotonin receptors 25075 25324 29581 24473 25187 65032 25689 29595 25323 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%10229246 SHC1 events in EGFR signaling 24329 24827 24605 59325 293621 81504 24525 25433 64022 25313 313845 29183 85385 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%10231196 Interleukin-36 pathway 499744 171106 296541 362077 311783 25466 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 97%10229794 Tachykinin receptors bind tachykinins 24807 29191 24806 24808 25007 ACTIVATION OF PKB%REACTOME%R-RNO-165158.1 Activation of PKB 25233 246273 81745 361992 HYDROLYSIS OF LPE%REACTOME DATABASE ID RELEASE 97%10230458 Hydrolysis of LPE SIGNALING BY TGFBR3%REACTOME%R-RNO-9839373.1 Signaling by TGFBR3 29200 81751 29591 29263 65205 81707 300802 54250 116510 289231 24504 29543 25387 29192 292788 59086 25388 81809 83823 29610 81810 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 97%10230858 Oxidative demethylation of DNA BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 97%10231452 Biosynthesis of DPAn-3 SPMs 287454 29527 81639 25290 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%10229118 G2 M DNA replication checkpoint 114494 25203 295052 54237 308937 287101 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME%R-RNO-156580.1 Phase II - Conjugation of compounds 25331 291394 63867 58953 246232 58962 83472 156275 24421 24423 24422 81522 24424 24426 360268 361510 29443 361637 78959 140925 290401 24912 297433 81869 494499 312952 25283 116632 116631 29487 300983 266685 24861 501907 494500 286954 362196 288617 25458 501110 113992 690050 309465 64352 64473 408206 116568 295037 25260 683630 24902 303953 681913 24297 499689 116684 688536 83783 293779 290681 286989 503103 360994 29566 171072 353317 64305 29739 171347 246263 290947 297029 171341 292915 24267 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-RNO-113510.1 E2F mediated regulation of DNA replication 682033 24672 24708 24673 117281 301323 315648 85241 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%10229718 GRB2:SOS provides linkage to MAPK signaling for Integrins 295347 25614 313845 24366 24367 685269 171337 81504 83805 29302 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-RNO-1971475.1 Glycosaminoglycan-protein linkage region biosynthesis 50568 25181 691984 25216 171517 25615 298690 304885 116673 24771 315939 246232 29139 317322 25236 58920 25592 25393 81651 114122 ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-RNO-9968297.1 Error-rone base excision repair (BER) hypermutates immunoglobulin genes 309812 50522 316235 289758 64156 316344 25737 192255 313702 100912032 G1 S TRANSITION%REACTOME%R-RNO-69206.1 G1 S Transition 312046 313138 313479 299112 298098 292071 362385 312538 291927 25233 307126 360621 24185 304573 362304 301430 85241 362485 499655 682033 366275 295052 287772 171102 292766 94201 308937 29669 83571 29668 114494 29425 64156 100360846 117263 25581 29666 315648 303353 365388 58919 117262 85492 24708 294790 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 24673 192255 81827 24672 287280 83806 311078 117281 100912032 307585 29414 266713 360908 301323 288532 316273 59102 295596 296178 29728 84389 RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 97%10231018 RAF MAP kinase cascade 25267 24629 24605 289257 293621 305614 64159 89807 24586 314251 81504 24525 25614 25150 313845 308458 363272 309168 65179 25266 288924 59322 29542 498576 64363 25443 29348 170579 170633 29302 309179 60352 299147 312754 29183 314612 170851 29622 295347 64022 24553 24446 25400 25344 687346 309548 56011 83805 65142 64511 25433 25313 302808 361171 25514 25318 64156 170818 364686 24888 309399 309153 24703 299617 361601 64030 315648 170668 24514 364052 305203 171109 63995 114856 297682 24329 58960 192213 312664 293847 361679 246781 289080 310533 50522 50689 25454 170577 363193 24673 25453 192255 25523 24672 300980 117281 66023 116590 100912032 25467 24412 25525 116663 60587 24592 360814 25597 314596 192126 25326 29372 304893 29376 59325 64053 171081 362572 117284 100909827 24245 24246 29495 60427 171140 25746 25513 305539 85243 296072 24244 116630 24716 85385 25704 25136 83613 116562 170911 25252 58948 114513 316213 25387 314850 24669 81511 25388 84489 83504 66017 25444 24366 24367 29349 54250 685269 25317 29434 287772 292766 29369 25022 171337 29368 170700 116499 29669 29668 60662 60464 170583 29425 289625 100360846 25114 170582 117263 25581 29666 315707 79114 303353 365388 29496 498596 432361 117262 24410 85492 24827 287984 25676 65138 114486 94198 305679 29673 29671 29670 29677 29676 29675 25594 81827 24408 24628 83806 311078 301555 362045 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-RNO-141333.1 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 25750 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-RNO-5250941.1 Negative epigenetic regulation of rRNA expression 302783 24829 302553 306945 303175 24828 309757 64627 117056 690795 680498 685909 680615 308911 365877 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%10231680 Signaling by LTK 25467 100910984 313845 170911 85385 303882 679566 25513 85243 81504 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME%R-RNO-977068.1 Termination of O-glycan biosynthesis 29758 25197 309114 303692 362924 363040 64442 497227 64445 690914 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-RNO-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 368001 296732 83833 361295 301020 361925 305589 361825 361711 292404 287876 293514 303518 297867 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229960 Adenosine P1 receptors 100911796 29290 29316 25369 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-RNO-168138.1 Toll Like Receptor 9 (TLR9) Cascade 363131 65052 64156 25742 81647 116725 314322 311245 315648 363328 309452 309295 81771 310877 117269 500133 60350 363520 29260 293624 291921 64044 300447 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 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81515 94201 100912032 83805 83571 100360427 64156 266713 315648 24514 680111 361178 84389 SULFUR AMINO ACID METABOLISM%REACTOME%R-RNO-1614635.1 Sulfur amino acid metabolism 691966 290947 79462 192172 24250 25274 25331 309732 298934 292710 81718 367181 170943 298227 83586 365972 25256 288912 24962 81522 81508 81805 29443 305177 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-5632681.1 Ligand-receptor interactions 89830 50938 84399 29499 84380 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%10228766 Regulated Necrosis 282834 364419 29197 64044 63879 365191 311567 287873 50522 64665 56816 246240 305549 266610 171528 25402 306886 83764 116502 246097 25309 117279 25385 690743 192255 679886 501083 246756 60371 363836 287155 361916 83841 353316 100912032 363720 690675 24493 64156 26295 299331 114562 299606 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%10230214 The NLRP3 inflammasome 117514 29665 282817 290408 315435 287362 58923 116484 301252 300732 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%10228814 Muscle contraction 64362 24838 24837 50688 24907 24585 296369 171409 290561 56781 24851 295261 500450 363925 294141 171009 29389 312981 24583 29388 295929 58814 58950 24245 24246 59299 171140 300992 116600 24244 689560 246150 140729 89821 140725 117018 59324 116695 116491 64120 25118 140728 25470 63883 681190 116489 24239 171138 367302 140727 445371 84429 65180 84020 116601 25400 688996 25679 170899 25391 276720 64672 81678 24211 29693 24212 24213 29600 63847 29599 63848 65195 65023 65272 29598 362013 29248 24852 65199 56817 58971 29431 259243 64190 308405 29432 116831 29639 29132 81818 288057 24590 83535 25560 113902 300838 25650 64119 364241 156873 25390 305679 29715 140447 140448 114593 116564 501203 289596 24603 24602 24598 360820 171115 25262 289759 116649 50685 304816 25202 25687 25206 66012 24584 296313 282843 361618 29712 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-RNO-442660.1 SLC-mediated transport of neurotransmitters 116638 171163 117100 113918 83612 79213 282712 79212 681896 24904 664630 29503 24898 298340 25553 116509 309111 266767 171148 83511 84487 INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling 171333 689932 25506 100361294 25125 24514 155140 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%10230946 CD209 (DC-SIGN) signaling 24605 293621 81515 81736 24525 29433 25150 29431 29432 24703 288375 360647 293508 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 97%10228624 ERK1 ERK2 pathway 25267 24629 24605 289257 293621 305614 64159 89807 24586 314251 81504 24525 25614 25150 313845 308458 363272 309168 65179 25266 288924 59322 29542 498576 64363 25443 29348 170579 170633 29302 309179 60352 299147 312754 29183 314612 170851 29622 295347 64022 24553 24446 25400 25344 687346 309548 56011 83805 65142 64511 25433 25313 302808 361171 25514 25318 64156 170818 364686 24888 309399 309153 24703 299617 361601 64030 315648 170668 24514 364052 305203 171109 63995 114856 297682 24329 58960 192213 312664 293847 361679 246781 289080 310533 50522 50689 25454 170577 363193 24673 25453 192255 25523 24672 300980 117281 66023 116590 100912032 24498 25467 24412 25525 116663 60587 24592 360814 25597 314596 192126 25326 29372 304893 29376 59325 64053 171081 362572 117284 100909827 24245 24246 29495 60427 171140 25622 25746 25513 305539 85243 296072 24244 116630 24716 85385 25704 100361294 54237 25136 83613 116562 170911 25252 58948 114513 316213 25387 314850 24669 81511 25388 84489 83504 66017 25444 24366 24367 29349 54250 685269 25317 29434 287772 292766 29369 25022 171337 29368 170700 116499 29669 29668 60662 60464 170583 29425 289625 100360846 25114 170582 117263 25581 29666 315707 79114 303353 365388 29496 498596 432361 117262 24410 85492 24827 287984 25676 65138 114486 94198 305679 29673 29671 29670 29677 29676 29675 25594 81827 24408 24628 83806 311078 301555 362045 FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-RNO-5654700.1 FRS-mediated FGFR2 signaling 24605 25443 293621 29348 170579 170633 81504 24525 313845 66017 25444 25622 29349 54250 25317 29369 25022 316213 29368 314850 170700 116499 60662 60464 170583 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 246331 50687 116549 24329 58960 24511 685269 170851 116590 24586 29302 50689 296456 29431 363875 81650 79114 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10229984 Bicarbonate transporters 315311 84484 295645 24779 297386 24780 24781 117955 266612 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 97%10230236 Regulation of IFNA IFNB signaling 298205 686326 298210 25622 288264 100911527 690894 312688 502959 24697 24481 100361294 116689 120103159 120103158 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 97%10230664 Phosphate bond hydrolysis by NUDT proteins 361274 287406 305149 117260 361068 INTERLEUKIN-10 SIGNALING%REACTOME%R-RNO-6783783.1 Interleukin-10 signaling 304091 100361294 25325 25125 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%10229818 Transcriptional regulation of white adipocyte differentiation 84578 25664 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-RNO-198933.1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 293618 689004 24223 289211 84349 313785 292844 292843 292846 307199 361673 288244 100910497 25066 680844 100360919 300649 362443 312711 309684 305081 574531 25361 24511 680842 300678 25300 24750 25710 24232 24974 499400 24988 24934 24931 365527 24930 498079 308417 308501 54266 308995 298702 498287 287818 353253 304349 689853 364049 474146 171369 89843 684984 25713 301229 100361633 360647 25109 25464 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%10229822 Regulation of IGF Activity by IGFBP 79438 24765 503164 24594 290257 56646 689404 25662 680415 25376 25641 94168 362862 83501 84491 25506 25373 25649 25728 24648 140638 24232 63880 79210 362859 683007 361029 59107 296290 288038 192152 25236 24484 363455 292848 54225 303743 29237 114122 24483 361676 60333 29417 691517 367252 25087 266704 24367 79224 85253 25268 25081 304917 170583 24482 25353 300338 24825 116640 116510 81686 29650 116635 171154 24186 25615 292485 24233 24259 406161 25307 29461 83476 308807 303635 289525 25434 24498 63878 300445 680692 313954 25277 298296 84595 304334 54226 360622 338474 25685 362182 83727 286906 315111 298683 79110 89842 25285 292905 29160 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-RNO-450520.1 HuR (ELAVL1) binds and stabilizes mRNA 170538 85252 363854 25379 24680 307947 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10230010 Sodium-coupled phosphate cotransporters 29502 81826 246234 25548 84395 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 97%10231676 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 302783 290939 299905 679693 24708 24829 306945 24828 84578 117056 85265 680498 83724 685909 680615 497991 25664 619436 365877 83516 291567 311860 300367 365755 302711 303175 306030 309757 140908 64627 299607 287475 303403 497941 690795 299180 317343 316209 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-RNO-166663.1 Initial triggering of complement 24232 24233 298566 406161 64459 29687 114091 362634 25419 64023 64668 100360919 312705 192262 299928 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%10231098 Fanconi Anemia Pathway 287634 362678 293489 691105 685055 50522 499155 363164 502320 302982 303742 192255 309256 312641 292127 314172 100360594 313387 360847 310745 501552 302953 293678 100912032 304719 64156 59102 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-RNO-1250347.1 SHC1 events in ERBB4 signaling 25433 64022 498596 432361 313845 24605 59325 293621 85385 81504 24525 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-RNO-141424.1 Amplification of signal from the kinetochores 298850 681050 83836 295661 363059 363198 304951 684439 289150 361416 304477 29564 65201 297522 83572 315648 294429 287830 292085 25515 287624 94266 309179 299147 252902 363193 312754 24673 29489 81738 362548 683983 29648 363174 24672 64515 681185 297176 298594 114592 170845 117281 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 85252 307805 81655 311191 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA Damage Checkpoint 140583 58936 117262 85492 114212 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 113927 192255 81827 287280 83806 311078 84027 361765 287772 171102 292766 100912032 29669 29668 29425 58822 64156 100360846 303024 117263 25581 29666 303353 365388 GLUCURONIDATION%REACTOME%R-RNO-156588.1 Glucuronidation 83472 286954 286989 303953 113992 63867 266685 246232 501907 24861 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-RNO-194306.1 Neuropilin interactions with VEGF and VEGFR 246331 25589 81527 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME DATABASE ID RELEASE 97%10231428 Biosynthesis of E-series 18(R)-resolvins 29328 81639 299732 25290 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%10229240 Conjugation of phenylacetate with glutamine 246263 IRS ACTIVATION%REACTOME%R-RNO-74713.1 IRS activation 25467 29376 498416 24506 24505 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling 25614 25150 64465 25311 300955 310192 363875 83805 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%10230640 MASTL Facilitates Mitotic Progression 307169 60336 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 97%10229988 Sodium Calcium exchangers 314396 24244 29715 311387 84550 140447 85267 56814 140448 498185 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-RNO-9825892.1 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 312451 690660 84353 161452 297893 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 24483 29376 25443 170911 29348 25233 361388 81745 170579 170633 81504 84477 313845 363131 246273 84489 29516 25718 361992 83504 315761 65052 66017 25444 25622 29349 54250 25513 25317 29369 25022 85243 29368 314850 170700 25467 116499 60662 60464 170583 24482 289625 25114 170582 85385 79114 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%10228904 Cytosolic sulfonation of small molecules 292915 24912 24902 297433 312952 300983 58953 83783 288617 503103 171072 64473 360268 64305 361510 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 97%10230444 Beta defensins 310553 641632 641627 641636 641651 641650 83687 308163 641624 641644 641652 641655 641657 641656 305354 641658 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 97%10228622 RAF-independent MAPK1 3 activation 63995 114856 297682 54237 58960 300980 25622 293847 170851 116590 361679 24498 50689 116663 60587 100361294 24514 364052 171109 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME DATABASE ID RELEASE 97%10231540 NPAS4 regulates expression of target genes 266734 29657 25242 84469 25243 NEURONAL SYSTEM%REACTOME%R-RNO-112316.1 Neuronal System 25590 266706 29422 25103 54239 25753 54240 79213 66016 29747 117018 25716 25468 25469 294065 295360 246153 117023 114032 59324 116563 116695 307234 171011 116491 64120 24957 66022 84390 81657 365241 24398 259273 25559 60326 25470 25472 116489 83588 290467 294961 29548 445371 29547 246325 116647 116745 192268 59266 116724 300913 25327 29546 84429 83731 312855 688721 65180 365222 84020 65198 310519 65040 170739 171297 24520 58981 60391 54262 306147 54261 286930 25736 679668 685472 296395 60355 116681 29738 308495 29737 54263 306152 171146 308571 25400 310303 302473 688996 309349 170899 78957 50564 117096 29731 25529 276720 304733 114244 313052 114245 116508 307900 116595 684516 27150 309557 64665 65195 362979 65272 29613 315435 500219 294380 59312 83764 315840 140945 140670 50592 24418 24904 24414 29503 83633 81771 117269 25531 501560 29709 29708 64830 64832 25743 25466 170847 24379 24412 24411 116649 29707 24898 79130 29705 140592 170567 171131 24947 60422 24949 29559 29713 24267 116470 29712 24803 116638 29718 24380 81721 79246 83589 58963 84556 50688 64053 317553 65024 29647 298521 81632 29483 79557 64199 60377 54257 286924 83506 29642 84347 24611 308868 79218 29482 117284 497009 24407 81636 24406 24409 245986 293645 24245 24246 60449 25456 293508 24922 302950 29539 59317 294962 29495 64532 25297 25451 25521 25686 25450 85426 25289 25643 171140 29130 25725 300992 116600 83579 29241 25302 680149 29629 25549 84420 58979 29628 29627 24244 79212 79211 140675 114117 366432 24400 64508 50599 363447 25050 171571 140729 66028 81667 25553 24681 25674 29699 25558 24680 116560 25550 81664 66013 25398 60341 60442 171163 140724 84591 140725 65187 170945 83613 25023 83612 192258 24397 306243 29695 29694 58942 84016 25252 171503 29179 553106 84012 58948 191573 25012 24468 83535 25560 360406 24410 24408 50676 65046 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-RNO-3000171.1 Non-integrin membrane-ECM interactions 25216 170921 24907 29302 309816 691517 296456 59086 25724 303468 25615 24511 432360 362715 54250 500364 116673 305941 24771 497892 25600 298936 307548 25592 66027 114489 299940 24680 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 97%10230210 Interferon gamma signaling 89829 171140 25400 116590 300772 170538 50689 301442 360697 24703 500538 116465 25712 116689 24245 24514 24246 117063 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-RNO-9860276.1 SLC15A4:TASL-dependent IRF5 activation 84351 309361 501570 246280 309295 SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism 316033 500961 65196 25524 304208 353229 499174 366065 360618 500624 312382 58970 312689 24565 296188 80773 361213 314438 100270678 83626 83505 310667 500651 170897 366697 366984 307855 310849 360833 308589 365984 499210 286896 313339 301118 246115 309147 310508 363494 114104 303729 25227 311013 316642 83537 303631 117185 289687 94338 315222 24800 65183 365619 310326 407765 684536 362409 307404 84431 116740 81919 58924 300757 64828 683713 301525 50555 362275 300129 364901 64442 64445 63888 294673 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230078 Hydroxycarboxylic acid-binding receptors 689936 353250 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-RNO-9853506.1 Succinyl-CoA Biosynthesis 298942 299201 360975 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-RNO-1236975.1 Antigen processing-Cross presentation 117262 295279 85492 24223 24974 287984 499400 65138 94198 24988 29673 29671 29670 498011 296456 29677 29676 29675 365527 79129 66021 64630 81827 24968 24967 83806 311078 29614 29528 680842 83730 287772 171105 292766 29669 29668 24750 29425 100360846 502852 117263 25581 29666 291983 29468 303353 365388 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 97%10228690 Ca-dependent events 302950 64532 25521 25289 25725 29241 116590 84420 24244 170538 83506 64508 81742 25050 81636 24681 29699 25238 24680 60341 29691 293508 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-RNO-2299718.1 Condensation of Prophase Chromosomes 302783 25203 315508 300149 24708 54237 24829 306945 25515 362519 303175 24828 689820 317425 64627 690795 685909 307947 680615 365877 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10231068 Complex I biogenesis 26203 26202 26201 300447 362440 360826 303922 289218 293114 301427 25488 293991 313450 64539 361520 298748 293655 81728 362495 291671 293453 296190 298147 293130 678759 294973 299310 100912357 499529 315167 26194 362588 296086 26199 361894 361385 690354 301123 497863 56769 681418 26193 301458 296658 297821 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes 83836 64158 311802 306599 366403 316531 29753 81740 192228 29479 296554 363055 29213 305467 294010 29214 500069 692032 83572 290626 305882 309098 315423 171566 367153 314787 683722 360672 308064 100362495 362980 311573 293844 310344 56010 311529 362203 58822 287929 246150 300963 308663 252921 64462 680991 60347 307347 54237 25515 299850 29489 117281 29167 311191 114764 58945 299331 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-RNO-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane 301626 192275 313648 363160 290783 499342 64701 100188932 362040 116967 309304 290638 686092 CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism 290551 81508 291450 85254 114123 363024 64037 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME%R-RNO-420597.1 Nectin Necl trans heterodimerization 308417 363058 25066 360882 192183 498281 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME%R-RNO-9860927.1 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 56611 24672 311860 24511 117104 117281 81736 29302 305679 25614 25493 84351 296456 309361 24627 29156 81666 24697 29154 315648 81662 309295 363014 PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway 362550 306782 314212 282581 364754 100360552 64303 303251 688319 25388 363875 64558 140670 287772 292766 117273 29669 29668 29425 64156 100360846 117263 25581 24681 29666 24680 303353 365388 117262 85492 25023 287984 65138 303811 64512 94198 317674 29673 50522 29671 29670 29677 24881 29676 83721 29675 84426 140584 192255 116561 81827 116563 83806 311078 100912032 690516 65046 83800 266715 54241 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-RNO-110313.1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 309812 299112 316235 171525 298098 288003 362385 116468 298693 25737 304573 288414 50522 116643 292101 300795 84478 307905 192255 140639 100147704 59294 295704 289508 100912032 289758 64156 316344 89809 59102 313702 361698 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport 298203 114766 64198 301418 688685 287979 295462 307350 171433 353231 365567 25344 364601 498185 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking 25751 24600 311111 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling 500526 81504 114486 50522 50689 24673 500985 84489 192255 306141 24672 66017 25444 25622 117281 29349 54250 116590 25317 29369 100912032 83805 29368 314850 116499 60662 60464 170583 64156 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-RNO-69618.1 Mitotic Spindle Checkpoint 298850 681050 83836 295661 363059 363198 304951 684439 289150 361416 304477 29564 65201 366381 292588 293155 296368 297522 361389 288671 290875 305420 360643 83572 315648 294429 287830 292085 25515 287624 94266 309179 299147 252902 363193 312754 24673 29489 81738 362548 683983 29648 363174 24672 64515 681185 297176 298594 114592 170845 117281 308443 303037 306464 679342 296137 291441 140734 24669 257649 257644 64041 287598 317252 85252 307805 81655 311191 361831 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME DATABASE ID RELEASE 97%10230162 Interleukin-3, Interleukin-5 and GM-CSF signaling 65038 25578 116562 170911 25155 25126 81504 287942 25150 84477 313845 366508 171081 500985 84492 25622 25746 25513 81515 85243 116630 25734 60664 54245 85385 25704 24918 116689 25326 24514 54259 SENSORY PERCEPTION%REACTOME DATABASE ID RELEASE 97%10228430 Sensory Perception 307096 25216 78979 286924 690448 29216 361266 554302 353252 364773 60449 498790 498789 24717 83579 680149 313689 171516 24244 24539 680188 24400 25649 25728 25122 292697 191574 500101 24768 24767 25080 296972 691984 171517 24710 25703 24856 25702 25680 192259 116673 24771 299858 362558 64047 89810 317322 25236 100270683 302425 315644 58920 314941 25592 25056 55939 54225 289878 81644 689869 688297 170634 307401 25679 266761 300027 259274 363071 293049 314264 64511 266714 25081 24711 89826 25318 500091 499132 317498 500089 316218 85259 100310876 363143 291318 301233 29481 140936 64370 25539 116556 59077 79222 29407 25615 299521 81760 78981 78980 78983 78985 246219 291283 307092 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9937383.1 Mitochondrial ribosome-associated quality control 303746 295238 293054 309176 298517 293754 297799 361883 363023 301552 299628 497876 683519 315141 288916 294230 309140 100363539 360594 500199 299938 292758 293453 287962 295224 296551 171061 292244 363646 689432 361005 310653 362216 297601 56281 309440 287656 297459 301250 301371 364656 287302 293666 296134 303685 64360 113958 294767 684304 680747 301352 290850 297372 301240 498406 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%10228910 Dissolution of Fibrin Clot 24617 85253 56611 25692 60325 681544 81778 291085 50692 29366 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%10231640 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 314641 81679 293142 116549 192275 84430 688673 313648 83502 300445 64701 29144 100188932 362040 29606 25507 78947 54281 293721 266758 84353 81650 686092 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-RNO-8866910.1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 314993 24890 25329 116700 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 97%10230216 Regulation of IFNG signaling 300772 89829 301442 360697 116465 25712 24514 117063 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%10230910 NIK-->noncanonical NF-kB signaling 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 361765 287772 292766 100912032 117553 29669 29668 29425 64156 100360846 309361 303024 117263 25581 29666 360640 309452 303353 365388 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 97%10230074 Rhesus glycoproteins mediate ammonium transport 310625 65207 293048 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231576 RND1 GTPase cycle 84510 365355 310999 367235 305605 192277 65183 83764 302855 498547 306871 301007 84427 116478 315829 64678 306400 366492 289229 25306 360849 498331 310074 25513 316213 362993 314850 299012 312667 192207 305645 140922 304893 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%10229750 Cell junction organization 83427 63879 83501 25066 25150 292064 25507 313806 100361294 362850 316639 313474 363509 25125 360652 301334 304297 84353 81679 311163 300289 25751 362279 314641 50654 83502 25697 691517 266758 363875 362973 81634 170922 362332 60371 362650 57341 293860 293142 29460 84430 24511 688673 25705 81717 500569 689820 287772 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 29425 64156 100360846 116479 54281 24790 83712 307237 117263 81918 25581 29666 81650 24514 303353 365388 302783 117262 85492 192275 24829 306945 287984 24828 65138 313048 94198 29673 50522 305679 84006 100188932 29671 361866 29670 117056 29677 680498 29676 29675 685909 680615 192255 365877 686092 308417 64315 81827 304109 25724 64465 116549 26955 498515 83806 310174 311078 192248 360820 117048 313648 192183 303175 360687 498281 688041 301887 29181 100912032 84407 497229 24498 81736 303068 300445 361432 363058 29144 25409 64701 64627 29606 500870 78947 690795 29163 29162 293721 360882 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231308 RUNX3 regulates CDKN1A transcription 24842 50554 59086 156726 25631 LEUKOTRIENE RECEPTORS%REACTOME%R-RNO-391906.1 Leukotriene receptors 59264 114098 114099 170926 767613 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%10229684 Intestinal lipid absorption 432367 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-RNO-69231.1 Cyclin D associated events in G1 58919 24708 294790 117104 684111 50522 399489 81758 64033 362485 24673 25164 25193 494444 192255 499655 682033 24672 366275 311860 287280 117281 114483 81515 94201 100912032 83805 83571 100360427 64156 266713 315648 24514 680111 361178 84389 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 362625 295319 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 97%10231632 mRNA Polyadenylation 366693 308968 689116 687575 298075 289561 292778 117259 305586 311670 299256 299811 83503 117017 289582 498109 302969 363633 494445 29578 81781 300996 313030 24668 29667 313035 79256 292019 64200 362687 499314 319110 361808 291295 317612 117280 117282 64156 689890 500538 361814 291794 362361 307474 84401 687711 116697 288701 680891 50522 363005 683927 245957 100362099 304859 681031 100361269 302855 365407 500242 192246 314417 308650 192255 25594 362152 303607 686980 80846 171365 313583 680737 305479 311166 140931 361859 290614 100912032 287768 29497 299620 295270 304277 290666 288588 291877 64510 316123 361542 690966 84486 292729 361365 361788 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 97%10230472 Synthesis of PI 361694 304474 192260 287467 81925 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 97%10231660 Mitochondrial protein degradation 303746 24450 688685 25176 307350 25557 24368 353231 114096 289950 297376 298942 79250 170916 300786 26197 299857 298079 293655 170587 291671 29539 497902 29215 26195 113965 301458 94194 65155 300677 94271 25618 361338 641434 83474 192241 65262 171374 361596 117099 690163 81829 64539 63868 503049 307270 360975 50559 365699 63864 293448 64526 24399 25014 361755 252934 54226 29611 314304 309441 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 97%10231318 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 304690 25697 29175 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-RNO-6806003.1 Regulation of TP53 Expression and Degradation 25405 54237 115771 114212 296648 25233 360471 81745 24185 282844 50522 315189 310131 24673 300711 282845 192255 24672 24842 295052 117281 64226 100912032 311575 304798 114494 29414 64156 56718 315648 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%10231712 Modulation of host responses by IFN-stimulated genes 84351 309361 295704 298693 309295 310968 361810 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229746 SDK interactions 360652 304297 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME%R-RNO-9943962.1 CHD6, CHD7, CHD8, CHD9 subfamily 302783 24829 306945 312974 311607 303175 24828 362093 83726 64627 117056 690795 680498 103690021 84353 685909 680615 65027 365877 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%10229088 Cytosolic sensors of pathogen-associated DNA 293624 287707 50522 84351 304859 499069 84353 498840 192255 299827 301059 304987 100912032 81736 314336 292892 25493 310461 64156 309361 308901 309452 64046 313264 309295 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231198 Interleukin-18 signaling 373540 29197 301365 84388 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%10228242 Glycogen metabolism 24244 690987 678739 29353 361377 309513 140671 367562 64035 81675 307091 362029 PEPTIDE CHAIN ELONGATION%REACTOME%R-RNO-156902.1 Peptide chain elongation 29565 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 290823 117262 85492 407784 64562 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 116643 192255 81827 25520 83803 83806 311078 362891 289874 287772 373545 292766 100912032 65248 499342 29669 29668 690315 29425 64156 100360846 360967 117263 25581 29666 303353 365388 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-RNO-177135.1 Conjugation of benzoate with glycine 293779 246263 688536 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 97%10228848 Interconversion of polyamines 308652 SHC-MEDIATED CASCADE:FGFR1%REACTOME%R-RNO-5654688.1 SHC-mediated cascade:FGFR1 83504 24605 66017 293621 25444 25443 29349 54250 25317 170579 170633 81504 29368 24525 170700 116499 60662 313845 170583 85385 79114 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-RNO-168176.1 Toll Like Receptor 5 (TLR5) Cascade 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 TRNA PROCESSING%REACTOME%R-RNO-72306.1 tRNA processing 361201 319113 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%10228130 DNA Replication Pre-Initiation 312046 313138 313479 299112 298098 292071 362385 312538 291927 307126 360621 304573 362304 301430 85241 366381 292588 293155 296368 361389 288671 290875 305420 360643 287772 292766 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 302783 117262 85492 24829 306945 287984 24828 65138 94198 29673 50522 29671 29670 117056 29677 680498 29676 29675 685909 680615 192255 365877 81827 83806 311078 303175 100912032 64627 690795 361831 360908 301323 288532 316273 362607 24917 59102 295596 296178 29728 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 97%10228578 Processing of Capped Intronless Pre-mRNA 689116 171365 681062 680737 311166 298075 311670 299256 687711 116697 366468 501688 299811 289582 683927 304277 100362099 291877 681031 365407 314417 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%10228834 Regulation of clotting cascade 24617 308637 25216 360918 306761 25087 29436 171154 306608 499099 260320 691984 302470 171517 25615 362248 116673 24771 315272 24946 79224 29366 691992 25268 502858 295703 317322 25259 65051 304917 116727 25236 29243 314615 58920 54226 25592 83580 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%10228768 Release of apoptotic factors from the mitochondria 100360940 116502 25309 287606 353316 690675 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-RNO-388844.1 Receptor-type tyrosine-protein phosphatases 306147 306152 308571 302473 317553 309349 25529 25466 360406 290467 29613 300913 140592 312855 293645 310519 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231364 SLIT2:ROBO1 increases RHOA activity 117273 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 97%10230432 Downregulation of ERBB2:ERBB3 signaling 29496 50522 432361 29414 64156 25233 24185 192255 296121 100912032 362814 GABA RECEPTOR ACTIVATION%REACTOME%R-RNO-977443.1 GABA receptor activation 29718 65187 192258 29695 29694 64199 286924 24611 79218 81636 245986 60449 24922 302950 294962 64532 25451 25686 25450 25289 25643 29709 29708 83579 81657 29241 680149 25743 84420 170847 58979 79211 116649 140675 114117 29707 24400 50599 64508 29705 81667 83633 24947 116560 29713 81664 66013 29712 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-RNO-157858.1 Gap junction trafficking and regulation 266706 79128 116563 292994 84403 25655 50563 50564 83805 394266 25751 29585 497913 29584 315840 24392 29586 79217 83800 54241 363677 266707 116561 140694 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 97%10228486 Transport of Mature Transcript to Cytoplasm 689116 687575 298075 299256 362098 289582 259170 297522 494445 89827 79227 29667 59087 501621 362687 290519 287113 689890 298385 360726 361814 294429 287830 291874 362281 681062 113975 292085 295692 360972 117021 362335 315170 288701 295284 366016 313308 58958 362557 65274 113929 296219 114612 362819 245922 81738 313449 683983 53372 690303 305714 25497 361990 499974 690585 361859 303057 688288 117045 304277 361542 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 97%10230422 TWIK-related spinal cord K+ channel (TRESK) 445371 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10230192 GDP-fucose biosynthesis 311204 293587 310935 291095 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 97%10231592 Drug-mediated inhibition of MET activation 24553 24446 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-RNO-5654733.1 Negative regulation of FGFR4 signaling 500526 81504 114486 50522 50689 24673 500985 192255 306141 24672 66017 25444 25622 117281 29349 54250 116590 25317 29369 100912032 83805 29368 314850 170700 116499 60464 170583 289625 64156 25114 170582 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 97%10228562 mitochondrial fatty acid beta-oxidation of saturated fatty acids 140547 29470 25287 25363 64304 24158 113965 171155 170670 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-RNO-2559582.1 Senescence-Associated Secretory Phenotype (SASP) 117269 302783 24829 306945 24828 366381 50522 292588 50689 293155 296368 361389 117056 288671 290875 680498 305420 360643 25164 685909 494444 680615 192255 365877 501560 24253 295052 303175 116590 114483 94201 100912032 83571 114494 64627 690795 64156 361831 81771 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization 50689 64528 81754 498266 25515 116590 65158 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%10230324 TRAF3-dependent IRF activation pathway 292892 293624 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors 25652 498475 81752 170926 25637 24816 24929 59264 292661 63889 309212 114098 114099 767613 84023 HCN CHANNELS%REACTOME%R-RNO-1296061.1 HCN channels 59266 84390 114244 114245 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) 689116 298075 501582 24420 100125373 287596 691397 287522 365215 171350 361271 360855 684558 307503 259170 287113 291434 81729 25347 29304 25348 28298 65136 27139 298385 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 295284 94266 140654 140655 313449 690303 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 81773 81774 245981 497860 81770 361109 117104 691531 64640 83789 81764 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 29285 124323 29284 29283 29282 296709 64302 64306 100360439 64307 64156 122772 134486107 50522 24672 117281 688288 INTERLEUKIN-12 SIGNALING%REACTOME%R-RNO-9020591.1 Interleukin-12 signaling 84405 171334 171333 25506 85491 100361294 24514 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 97%10229182 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 25203 117262 64193 85492 54237 25515 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 64515 83806 297176 295052 311078 287772 292766 100912032 29669 29668 114494 29425 64156 100360846 361831 117263 25581 29666 303353 365388 REGULATION OF BACH1 ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231586 Regulation of BACH1 activity 304127 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%10228586 Processing of Intronless Pre-mRNAs 689116 311166 298075 311670 299256 116697 299811 289582 683927 304277 291877 365407 314417 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%10231692 Maturation of TCA enzymes and regulation of TCA cycle 363061 157074 298596 361726 289217 293615 25014 361596 79250 362323 290985 288740 499125 102550385 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 97%10230864 Metabolism of ingested MeSeO2H into MeSeH INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%10230224 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 362474 301624 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230820 SUMOylation of intracellular receptors 83614 58851 362827 690244 25154 24413 84385 363287 83826 300772 25573 24890 24873 25747 24705 60349 301442 499417 83422 81812 60351 24208 25672 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome 307347 83836 54237 64158 311802 25515 366403 316531 29753 81740 192228 299850 296554 29479 29213 363055 305467 294010 29489 29214 500069 83572 290626 305882 315423 367153 314787 117281 683722 360672 308064 29167 100362495 311573 293844 310344 56010 311529 58822 311191 114764 246150 58945 300963 299331 252921 64462 60347 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-RNO-5620912.1 Anchoring of the basal body to the plasma membrane 304007 287612 83836 117103 64158 311802 307724 366403 316531 29753 81740 192228 29479 296554 363055 29213 305467 294010 29214 500069 83572 290626 305882 315423 367153 314787 683722 360672 308064 689779 100362495 366872 311573 308923 293844 300880 303915 310344 56010 311529 680407 287383 58822 293148 246150 296136 313170 300963 287836 117515 361727 252921 64462 266809 309486 60347 307347 54237 25515 299850 29489 117281 308443 81830 29885 29167 311191 114764 58945 299331 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%10231466 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 114097 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 97%10230620 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 29591 25522 100912032 117273 690516 50522 64156 116479 59086 81918 310655 192255 81810 PI-3K CASCADE:FGFR3%REACTOME%R-RNO-5654710.1 PI-3K cascade:FGFR3 66017 25444 25622 170911 29349 54250 361388 25513 25317 29369 81504 314850 29368 116499 60662 60464 170583 84489 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%10228966 Attachment of GPI anchor to uPAR 316400 353304 295543 303277 50692 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 97%10229194 Phosphorylation of Emi1 64515 25203 54237 292263 25515 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-RNO-416482.1 G alpha (12 13) signalling events 317598 298404 287537 287418 310460 307098 84009 120099896 246174 311647 363509 310635 367901 310999 24816 78966 140898 361921 307398 295378 309653 117020 313845 303634 301334 295449 363460 316009 81663 310192 114513 293024 100362710 687105 362648 304109 114559 25537 29491 117273 64373 306618 29413 66013 29412 500608 NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance 29539 24904 29503 308868 24898 25553 24267 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-RNO-176407.1 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 366381 292588 293155 296368 64515 361389 288671 290875 310806 361831 305420 360643 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10230964 RHO GTPase cycle 116717 117259 360915 361940 29448 60431 78967 305614 64159 305457 307035 360509 290396 307562 81504 366608 314249 312108 360500 313845 305987 81522 315992 362456 299857 305234 292756 308509 315121 29579 309168 25096 308875 498282 296323 309696 310833 306183 305938 63994 312113 362842 313438 308097 500287 306357 306279 246249 291694 688429 362893 314618 288093 307459 305156 367085 498130 313388 360840 314903 309362 305367 361617 303583 84014 303222 303501 295635 304282 29146 287746 500246 64351 170824 83620 84031 300955 679934 316639 300067 307016 300186 286928 304546 292279 302976 117542 311450 29355 304530 311793 498798 308021 25488 303653 114116 25097 114243 79249 365407 79129 66021 294568 315348 81679 308666 362271 313024 116666 58823 682937 311030 29611 310519 314212 306152 688319 64665 83764 315840 306871 81634 64630 81818 299809 117273 313050 360678 261736 29528 171115 306417 313934 299331 117039 304893 308968 503165 24392 301252 84427 56084 363235 25513 64373 60664 306618 66013 317598 298404 287537 287418 310460 307098 120099896 246174 25437 170911 311647 363509 50646 310635 310999 25270 78966 140898 361921 309653 117020 303634 307170 301334 65183 363460 310192 302855 291755 114513 293024 301007 29648 100362710 293497 687105 363009 362648 116685 116478 362938 362859 315829 303553 361029 306400 64678 287543 366492 289229 25306 306506 89816 360849 498331 310074 312077 316213 314850 299012 312667 192207 305645 140922 362279 29275 56785 64160 363031 83809 54241 498174 309722 304007 315265 503306 365355 305341 685357 29681 297406 295588 297383 296060 310621 360942 100360623 117955 315686 367235 295378 361813 54308 305605 24852 192277 29431 310090 29432 366170 498547 363875 303888 679082 296162 24255 313216 300030 171581 500929 300115 315732 309175 25230 690130 310013 24511 300225 83615 303611 85428 300111 362988 291999 362993 171296 246314 293947 312640 360596 79239 299145 313618 100363276 678766 313838 363445 317296 689997 315707 367902 114562 300838 29745 311721 54350 113960 291000 83425 84510 83709 363213 306004 65134 84009 29433 114612 116643 287876 316369 361882 304109 64465 114559 25537 308869 81822 192348 29491 301555 24264 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%10229876 Adrenaline signalling through Alpha-2 adrenergic receptor 24174 24175 25083 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-RNO-5654704.1 SHC-mediated cascade:FGFR3 24605 66017 293621 25444 29349 54250 25317 29369 81504 29368 24525 116499 60662 60464 313845 170583 85385 84489 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 97%10228850 PAOs oxidise polyamines to amines 308652 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification 83614 690244 94168 84491 260320 25373 24232 24873 407765 116740 364901 29237 361676 56816 25087 60371 363836 83505 316164 305291 365984 81726 308384 103689978 78973 304132 690251 298071 310935 114711 24210 140593 291095 501167 293060 360475 361187 300668 362547 315212 311530 300089 192351 293587 302915 29403 303692 25280 301155 300741 305268 287920 299346 313231 298541 311847 353227 29758 295051 288525 305351 294400 301674 25128 363103 304860 362031 363284 500017 64624 500262 308999 64631 362081 310363 313743 362511 498959 100360914 503446 29468 308283 304920 293023 287706 494223 58983 499114 171043 288921 83826 688993 313722 367785 305792 292757 290692 100909827 361219 498005 360818 361907 687364 290744 685860 309453 24413 303478 100909445 64202 362566 306750 363790 303336 291983 311881 300950 54237 116698 689226 117537 361268 316614 303792 300724 300849 117524 297592 316628 313445 81812 362859 306129 366854 24968 24967 361029 81816 29614 313101 314432 500587 24484 24577 300320 25672 84385 25737 25533 170583 287362 287876 25615 497672 64557 290997 290631 316794 298534 287927 65158 297561 25573 308755 301442 499417 690043 302502 296099 295052 360748 114494 117282 308669 293719 289468 361181 362827 362704 306257 24205 79257 83422 361381 79210 50554 81516 81920 25671 363455 361831 296121 303743 114122 304832 297893 362788 79224 313139 25268 29382 311204 304917 64156 116725 311245 309452 309295 24208 500133 116640 313121 362491 50522 684097 84478 140639 192255 29134 300837 83619 287280 308051 361765 100912032 360990 300445 25493 24890 312688 54226 24705 303024 315111 24919 290864 688466 503164 58851 315133 310375 313128 115771 312937 307503 301164 501145 304157 363109 288306 361190 297393 498272 100361658 297417 313427 81654 498486 310960 360518 308896 302488 302972 81759 290652 408217 363164 361495 304150 307905 499801 362636 314453 297593 171329 311856 293705 25154 288482 363084 298576 315911 360763 315639 304798 24244 360860 362567 361368 85471 311202 362520 299841 60349 493574 257647 114489 308390 361014 298012 498560 293494 315723 29545 360853 65137 313304 304298 63996 316440 311026 362258 291737 116718 315523 64460 296084 85423 114558 305581 29534 292406 100910143 25586 24257 114589 311169 81613 29142 83834 415062 83529 353251 54279 83532 691259 83531 309659 303878 266601 315807 366478 307992 362756 303277 288038 363060 304017 364032 304966 378774 207113 681194 313488 303923 117054 316583 288041 314180 305571 300017 362275 300653 287159 315075 363040 64442 292666 64445 360838 293667 100359675 293154 291132 24832 113910 316033 81506 316400 353304 313536 29640 681033 296394 494342 79112 362924 29561 502017 65196 116597 60378 25295 362133 50692 81716 60333 29417 117522 541462 362934 363104 367308 300027 64621 295543 29189 116658 59318 59313 690037 50864 312806 313216 192263 60351 691120 66015 25591 29240 287772 292766 29669 29668 29425 100360846 54281 83712 117263 25581 29666 25353 303353 365388 304135 266712 117262 297337 85492 362412 308282 295568 24829 293561 500636 306945 287984 307029 24828 116510 286761 65138 100360606 362093 363982 94198 29673 29671 29670 266670 29650 29677 29676 360665 29675 116643 680615 290638 365877 81827 83806 171565 311078 292485 24259 25307 29461 83476 308807 688041 303635 289525 301555 25434 63878 680692 313954 64627 25277 84595 304334 360622 304794 338474 25685 362182 83727 286906 298683 79110 25285 292905 83477 29160 24765 56646 50557 689404 25376 289257 305614 64159 314251 116696 117523 308458 292845 302415 60331 293453 360847 65044 292325 102550196 313233 83627 308440 102554393 299314 315728 171133 361142 499968 474348 497227 291958 306664 64043 299201 367384 286971 307838 286976 315263 29750 313878 362760 497619 171569 304571 297757 64456 500032 314655 685758 170501 294809 364630 362539 309114 308787 361886 100360475 293004 288611 120100673 310670 100361647 361412 312566 690914 315879 311952 311039 361332 300474 302499 300475 296290 29611 117152 171152 293345 292588 691517 296368 64550 361100 299957 367846 313961 691688 363269 361645 293528 102551929 303310 293967 298692 292311 690512 311548 689746 315214 362415 305470 362154 100137086 117273 308976 314300 100362554 288923 310261 303755 287444 498034 25747 170818 314644 309153 361925 116722 100361517 83499 288455 296651 299156 310632 171058 360571 305853 500088 171122 100364984 503269 81755 85237 171111 367242 689377 140665 309649 302931 102553119 689197 361664 316976 315134 24498 292876 29144 361749 25094 362862 83501 310207 307200 316131 364050 360928 305895 313020 245974 315405 313242 688913 309035 84607 688478 363259 500616 499016 89829 316228 302288 314457 25506 498559 315745 29168 303602 291339 499807 362762 494320 310324 311633 317381 29591 64310 64515 59107 114592 140673 25387 192152 64041 24468 287709 100362121 500545 192243 24874 81807 29560 64345 641452 64525 29452 306886 25388 25700 24255 25081 64154 363445 288700 25631 365793 500249 362162 361073 29357 54350 315059 363123 303539 24825 24827 65134 297428 363287 24942 304290 58842 363136 363273 299850 363064 293184 361531 81754 79434 81756 29489 24186 363283 317580 24233 252853 406161 312703 140940 65165 680424 685144 81655 79214 690961 89842 360915 29448 79117 29564 252889 93646 314030 297522 295461 291171 294010 500572 292074 310306 289994 501854 299799 50866 287899 290994 94197 54400 305253 171121 315668 24648 287367 64462 89868 290659 64351 300772 361705 63880 498798 29183 301012 24506 24505 287427 683007 114023 302470 304978 116666 117513 100360302 311030 81830 29167 24946 140734 58817 366061 288779 29243 58945 54225 501550 117103 60355 690252 367073 84589 266688 100912115 299075 60384 300674 64633 316091 291212 291990 306549 25423 84430 299121 688673 50592 309010 246310 117287 29565 362191 64528 295394 171049 309144 304579 84599 84590 287275 287276 25407 316342 64646 94189 305348 365314 680465 502125 89820 361207 294790 25532 25531 360471 361577 25227 84379 311013 25530 316642 303631 293456 117185 315222 309451 24800 252902 365619 307039 310326 362409 300888 307404 246117 79120 261736 252916 299521 246324 310411 309678 300743 56042 367915 26295 362414 117039 689102 362237 362599 306264 503165 29631 50645 252929 84428 56084 25490 171102 25498 288617 25649 29304 25728 26962 140638 683630 60373 362902 64520 25236 293418 171361 83789 24375 291325 140808 25478 25197 303100 308757 65271 362625 367252 295319 25547 29582 299756 81519 94273 140568 432392 124323 24367 287662 294429 500152 287830 291874 362281 113975 292085 445442 295692 117021 362335 366016 58958 362557 65274 113929 116635 245922 81738 307151 683983 313038 53372 171154 309626 25497 306608 499974 310258 303730 24842 501403 117044 298296 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-RNO-1912420.1 Pre-NOTCH Processing in Golgi 56761 65165 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors 83614 362827 690244 303310 296099 64520 300772 25573 301442 499417 83422 25094 367846 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%10231400 Threonine catabolism 25044 65151 360816 INOSITOL TRANSPORTERS%REACTOME%R-RNO-429593.1 Inositol transporters 114507 171147 252854 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%10229074 Cytokine Signaling in Immune system 84349 24605 293621 89817 81504 24525 25150 313845 301442 24683 25235 24684 500538 300955 305896 362678 362050 691105 100911527 690894 310968 300772 63880 499155 81746 24472 304266 312754 304859 291978 24649 502959 24481 502320 303742 120103159 120103158 314172 84472 171164 298205 311430 686326 29219 24963 298210 501552 60460 288264 311130 363006 81920 361831 24697 117063 25400 25233 361795 500910 360548 60371 170897 24391 81515 362788 313017 64511 313050 25318 64156 25742 24932 81647 116725 360697 24703 314322 311245 116465 315648 25712 24514 309452 309295 81771 310877 117269 500133 353218 302424 365581 363520 156767 25069 291921 117516 64044 296872 25008 25625 313121 683163 362491 287707 500592 25572 363855 25341 89814 25272 498666 50522 50689 500590 84351 498769 252878 24516 289014 363193 305549 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 295704 300980 308267 117281 361765 64624 50658 116590 291861 113894 117553 100912032 25466 317546 24498 81736 25467 29144 25493 689932 312688 29414 24493 116663 690369 54226 361749 309361 100911249 60587 688621 303024 54245 24918 303604 25325 25326 54259 116470 24835 24803 65038 290257 314870 25578 25216 29376 362862 362629 362628 317553 117022 362077 24185 498951 155140 287942 25556 361810 500836 310132 84477 25670 361677 171081 313173 25402 500985 296541 25084 688622 24245 29201 24246 84388 294515 365368 287287 373540 500616 89829 299827 84492 680609 25506 85491 171140 25622 25746 301059 25513 311783 25498 85243 81680 681112 116630 292892 170538 290655 25613 25734 444986 685840 682457 60664 85385 25704 25707 100361294 116689 81802 81803 81804 84405 171334 171333 245983 116558 54237 304091 116562 29197 170911 25155 50646 300177 298693 54287 25125 306204 25126 114558 365769 24667 116553 499744 289747 170819 366508 171106 25012 60582 301365 25489 24468 81807 641452 64525 25738 498416 287772 292766 29669 29668 29425 100360846 54281 117263 25581 29666 303353 365388 306231 359726 304545 117262 85492 287984 65138 94198 29673 29671 29670 29677 680498 29676 29675 287876 81827 24842 83806 311078 81822 171369 360640 24917 81635 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%10229702 Platelet degranulation 50693 682967 293886 94168 289316 308291 25673 24795 311795 25651 84491 307396 246328 299909 25266 63836 293676 294643 113947 25373 364206 24244 24648 81804 29302 114111 89811 360457 59086 83785 81809 25717 302470 24446 24483 360918 360942 316531 363104 25524 24189 25087 81634 170924 293860 24366 24367 685269 60327 24936 85253 304805 25081 309609 25313 24482 24944 305021 56782 361196 84590 54249 363015 500152 24617 100359512 24791 24825 246358 498299 445442 686539 29583 24153 116510 363195 305679 307986 24786 116635 54404 312159 360950 287876 140656 296488 24614 24186 29186 24628 245955 315989 304983 24854 81814 295703 116662 54226 140594 309186 681544 293628 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 97%10229904 Prostacyclin signalling through prostacyclin receptor 292661 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 97%10230588 Calcineurin activates NFAT 24244 361400 100361818 25639 24674 24675 29748 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) 316794 498749 362827 362704 85482 192218 24829 306945 361767 287927 361815 300711 690043 296099 360748 64012 303175 289757 363251 497672 314380 64557 64627 308669 116725 290907 289468 363247 259171 290997 64046 25019 290631 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%10228528 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 316794 171366 299112 316235 171525 85482 298098 288003 289777 287634 362385 116468 192218 290805 304573 25737 293489 298534 288414 287927 685055 310034 297561 305000 25573 308755 361815 306734 499417 300711 299638 302982 690043 297627 59294 311860 296099 295052 360588 497856 302953 64012 499870 294800 293678 498265 114494 498411 308669 64156 291787 116725 289468 100361529 689055 297486 361698 140583 362827 362704 24829 306945 50522 192255 303175 100912032 497672 293452 64557 304719 64627 83508 363924 289758 102551085 303194 315969 498119 89809 499966 290997 59102 64046 290631 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229218 Telomere C-strand (Lagging Strand) Synthesis 307798 307861 59294 364996 84490 288003 116468 290805 25737 288414 85241 308755 289758 301323 303238 89809 290232 59102 297758 294025 361698 500054 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-RNO-1299503.1 TWIK related potassium channel (TREK) 116489 65272 170899 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-73930.1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 79116 29240 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%10229506 TNFR2 non-canonical NF-kB pathway 84349 361795 500910 360548 60371 287772 292766 362788 29669 29668 29425 64156 100360846 117263 25581 29666 309452 303353 365388 353218 117262 302424 85492 365581 156767 25069 117516 296872 25008 25625 287984 683163 65138 500592 25572 25341 89814 94198 29673 498666 50522 500590 29671 498769 29670 252878 29677 29676 29675 192255 81827 287280 83806 311078 361765 100912032 117553 171369 309361 303024 360640 24835 SHC-MEDIATED CASCADE:FGFR4%REACTOME%R-RNO-5654719.1 SHC-mediated cascade:FGFR4 24605 66017 293621 25444 29349 54250 25317 29369 81504 29368 24525 170700 116499 60464 313845 170583 289625 25114 170582 85385 CO-INHIBITION BY CTLA4%REACTOME%R-RNO-389513.1 Co-inhibition by CTLA4 24672 25622 117281 25233 24185 81515 25408 83805 25150 313050 29414 309179 56822 299147 363193 312754 24673 315648 HEDGEHOG 'ON' STATE%REACTOME DATABASE ID RELEASE 97%10230084 Hedgehog 'on' state 289711 289712 304729 296532 84399 84380 289180 364475 361769 89830 691171 50938 25238 29499 140588 140589 287772 292766 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 117262 85492 287984 65138 311567 94198 29673 50522 29671 29670 29677 29676 25273 29675 113927 192255 81827 83806 311078 100912032 301555 690516 287643 304832 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%10228500 SLC-mediated transmembrane transport 79213 85256 681896 85254 50719 64201 170551 294255 287532 113918 314441 311168 29464 170566 29485 29484 282712 315439 252919 155205 192208 664630 246235 298340 170573 305540 309111 83500 365398 89776 29509 85333 246280 170943 266612 29502 65039 315311 94106 81826 503568 64018 296578 246234 291582 84484 25239 295645 58980 25176 297386 116642 680602 24780 24781 311839 498910 266998 65202 114511 29735 287478 246239 117261 295417 313139 65142 296969 311204 24904 306866 310808 29504 29503 50662 24221 29726 291733 317170 498185 305846 295455 311651 58976 170840 171135 192215 314637 316519 117240 361986 363985 56814 25715 306009 294698 314396 24784 24783 29715 311387 362861 294281 24782 84550 299903 140447 300051 85267 140448 289353 363115 363103 24898 170567 116509 266767 171148 83511 84487 116638 29483 29642 29482 85426 303205 64522 25551 304785 501925 295245 25139 294341 24778 24244 79212 65194 114507 171147 252854 366432 360539 309131 362403 54302 54301 25553 310732 25550 140915 84511 259248 171163 432363 83612 691209 29501 54300 308069 84012 83629 171373 289459 25548 84395 353307 60423 63997 140944 117955 58978 140860 24779 25552 65200 80878 25027 116726 83509 84551 307811 114629 25246 29440 360670 117267 297910 304784 301010 170698 64037 29743 117100 362188 50676 114613 50567 363024 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-RNO-193692.1 Regulated proteolysis of p75NTR 81751 57027 24596 29192 292788 300802 311245 289231 81736 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 97%10228702 Calmodulin induced events 302950 64532 25521 25289 25725 29241 84420 24244 170538 83506 64508 81742 25050 81636 24681 29699 25238 24680 60341 29691 293508 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%10228136 DNA replication initiation 299112 298098 362385 301323 304573 85241 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10231238 Rab regulation of trafficking 362599 117103 361987 294709 365372 363326 29448 25233 295333 24185 308942 60445 367073 29753 84589 360797 266688 303734 50645 64862 299075 114638 292074 64670 362983 501854 299799 363235 64633 290746 360827 94193 94197 287110 361555 313493 315668 360956 288700 365793 84590 315059 680465 363123 691042 25532 306229 25531 24855 313234 24942 361697 84379 25530 312257 289350 25183 29662 499768 246294 81754 171452 79434 307039 81756 361227 58974 366896 287427 79121 252916 317580 246324 316017 311911 81830 29885 207119 309678 300147 307868 288779 29414 313340 311880 367915 315999 287709 315756 501550 360768 292886 292760 311494 689102 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%10231730 Nuclear RNA decay 686980 689116 307446 292067 298075 300032 294975 288661 314836 300045 305586 170956 307850 289810 116697 306137 686999 313707 679140 366017 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%10229092 DDX58 IFIH1-mediated induction of interferon-alpha beta 311430 299827 293624 312937 287707 246244 304017 100912032 81736 50522 292892 25493 84351 54226 64156 309361 25742 315599 299331 301252 192255 309452 309295 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-450341.1 Activation of the AP-1 family of transcription factors 50689 24516 116554 81647 314322 50658 116590 25272 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation 362809 116643 79245 299331 171361 301252 29753 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%10230626 Synthesis of 15-eicosatetraenoic acid derivatives 29527 29328 24404 81639 266604 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-RNO-8863795.1 Downregulation of ERBB2 signaling 29496 498596 432361 24329 287155 117255 59325 64624 25233 24185 100912032 25433 50522 64022 25313 29414 64156 299331 296121 192255 114562 362814 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane 314641 65038 50557 305419 288762 85238 114554 116699 361659 298947 25532 497931 89812 80849 170911 171088 497932 116720 84018 366508 287533 246237 140607 64310 64633 309419 308584 367786 498331 360521 25513 94197 85243 305482 365865 500132 305935 282584 60664 317296 312634 361632 116723 54259 295674 289021 MYOGENESIS%REACTOME DATABASE ID RELEASE 97%10229766 Myogenesis 337868 64465 311860 499497 360600 309957 171046 25714 81518 299766 361432 83501 60352 498607 84382 360715 50938 297357 84353 29148 25720 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%10230974 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 84495 29240 367090 305957 81528 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228398 Purine ribonucleoside monophosphate biosynthesis 684425 117544 362329 289276 140946 287420 301005 288259 315150 295088 81643 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193368.1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 307096 65192 192242 498789 25270 171516 29725 301517 25428 79111 361266 25541 83724 246211 291283 191574 364773 83569 60351 498790 307092 79244 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-RNO-174430.1 Telomere C-strand synthesis initiation 307798 307861 301323 303238 290232 297758 294025 85241 500054 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System 25441 25103 305311 361400 24605 292844 293621 292843 292846 64159 29221 360509 81504 24525 25614 25528 24795 25150 313845 29385 309684 305234 84491 307366 363577 574531 81683 25096 308875 292409 499099 293130 25373 362893 314618 299314 25035 54258 24232 83578 315085 25097 81503 24618 310553 499925 499926 296290 641632 641636 641651 641650 24620 246238 24941 308163 299567 84007 171162 641644 84355 685161 100361909 310611 314615 641652 641655 84387 641657 641656 305354 498659 301034 641658 498658 29748 316010 286995 117152 613220 613223 613224 100361818 286958 29738 296354 613225 641627 24674 311558 50585 24675 83687 305842 170496 691149 493810 641624 308873 290856 25524 315435 306871 360618 361467 25087 58970 288305 60371 304822 299809 690158 81515 24590 353316 117273 83805 302526 300678 313050 361171 24888 445269 24932 362249 24159 24703 305355 311821 246358 300250 316519 64314 317676 25316 25047 293118 58940 100364984 361537 24599 24598 301512 24600 140665 309649 304987 117553 310461 79130 54245 290257 24223 362862 84477 361677 117284 361383 312647 299827 84492 113959 25622 680842 116690 301059 291339 25513 85243 306998 25734 24750 85385 308901 100361814 688730 29143 116689 304284 313264 363127 56780 259275 500361 445415 58949 499157 690906 295279 317335 306324 290923 24974 100125364 170911 64185 25155 303180 308632 499400 497195 291091 81641 295214 311567 29205 24988 474169 360914 362638 306760 287721 498128 25012 498234 64681 84397 84398 291755 304692 291854 365527 290409 304543 192177 85274 25739 362859 302495 500324 298792 684322 298682 266775 100362805 304988 288778 501546 58826 83730 303542 192264 291948 24251 292537 29714 83462 25319 362966 361635 25751 293753 25328 84586 288174 295706 24468 287709 25455 302890 291759 450222 25425 360445 25308 289318 361422 25151 64527 314843 690263 306332 298066 29292 315916 89824 362431 363522 313837 300857 25046 50654 29521 25741 25505 378947 170923 246272 25697 83799 29175 83781 641452 246250 295378 29665 363463 81511 292804 113940 100360919 25060 366988 25738 29337 246240 24189 266610 297932 29431 363131 306886 29432 298103 366962 363875 29757 289407 362802 65052 368044 296981 298451 24191 299971 170667 24642 436582 297566 312488 117596 94170 116664 366545 63865 25518 684440 361689 317468 24206 81732 24699 25374 289032 81687 300732 117514 29433 282817 360557 290408 29192 246294 287362 58923 29489 287876 289820 315949 64189 65192 64465 155012 113936 24233 298566 406161 81822 83841 64459 301005 24854 54227 24237 24479 289231 29687 365466 58857 114091 362634 25419 295703 64023 64668 362329 54243 79126 117512 29333 24248 312705 363247 192262 501072 299928 289395 303861 64046 297518 29448 29214 79209 299825 288669 50866 311860 314787 94197 294329 315272 314336 24648 25019 300955 679934 286928 117542 63880 60352 360854 24472 296456 171574 304859 499069 79249 84353 79129 66021 287427 294568 315348 81679 311430 308666 114023 362271 313024 58823 682937 501570 81824 246280 295347 81920 288779 361831 58945 54225 367562 64035 81675 24434 362029 117538 309014 289211 259242 310178 79113 361527 65261 367901 25017 360426 361378 116484 287610 310864 83782 296654 64630 690945 25423 291359 296321 299121 680127 287545 246116 252961 362788 29565 64156 25095 25742 81647 116725 290029 314322 311245 315648 361929 363328 25407 309452 309295 499271 81771 311396 140694 310877 292072 117269 500133 306600 60350 363520 29260 156767 293624 84497 291921 25531 64044 363494 300447 313121 361697 362491 287707 25227 84379 363855 364867 25272 50522 50689 84351 24516 29662 315222 289014 363193 252902 305549 116667 307039 24673 315599 500900 315994 84431 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 246324 300980 29692 308267 117281 361765 50658 116590 291861 100912032 317546 81736 448830 25493 312688 116663 54226 309361 367915 60587 303024 299331 24464 78963 58918 312937 81745 50645 252929 24426 301252 288375 293508 25551 29684 679787 25110 498888 24244 170538 292892 29511 140868 29340 432363 299732 246244 25290 502902 362432 64171 450223 64537 24257 81613 29142 171341 24856 304017 304966 94167 292666 293154 294673 316033 81506 292073 29681 307833 94195 171361 24375 50692 100360623 296554 59313 116547 24440 690130 65197 24366 24367 24691 287772 292766 29543 171337 29669 499285 29668 140914 24944 79239 29425 100360846 116967 117263 25581 29153 29666 54249 81650 309147 303353 299606 29364 365388 683849 291000 302783 117262 85492 25406 24829 29583 306945 24153 287984 103690254 24828 291085 65138 306761 94198 305679 29673 29671 362347 29670 63849 117056 29650 29677 25052 680498 29676 29675 116643 498840 24934 140656 680615 365877 24614 56611 81827 29186 83806 308995 311078 292485 308869 313648 25307 303175 64627 362045 301229 681544 360640 24917 360647 363024 83477 312562 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-RNO-432030.1 Transport of glycerol from adipocytes to the liver by Aquaporins 65054 29171 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-RNO-901032.1 ER Quality Control Compartment (ERQC) 50522 64156 192255 100912032 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10230114 IL-6-type cytokine receptor ligand interactions 290655 289747 310132 245983 313173 25707 100361294 688622 29201 24514 81680 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%10231608 Regulation of CDH11 function 81679 311163 84353 362850 300289 84407 303068 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%10230836 Repression of WNT target genes 29382 312451 81717 161452 25565 84424 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination 289777 362960 499870 498265 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231508 FLT3 Signaling 24605 293621 170911 25233 498416 25513 24185 81504 24525 29414 84477 313845 294515 RESPONSE TO METAL IONS%REACTOME%R-RNO-5660526.1 Response to metal ions 689415 117038 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693565.1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 316794 362827 362704 85482 306257 192218 114212 24829 306945 287927 50522 25573 313539 361815 301442 301128 300711 192255 690043 65179 292172 116554 311860 24842 296099 64012 303175 100912032 497672 368002 64557 156826 29722 64627 308669 64156 100359714 293719 116725 289468 290997 64046 290631 502935 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-RNO-6811555.1 PI5P Regulates TP53 Acetylation 140607 290744 24842 89812 364298 116723 114495 DEADENYLATION OF MRNA%REACTOME%R-RNO-429947.1 Deadenylation of mRNA 117045 303831 171350 360760 688288 PROLACTIN RECEPTOR SIGNALING%REACTOME%R-RNO-1170546.1 Prolactin receptor signaling 287280 24683 89817 25235 361765 24684 24391 24514 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%10228882 Mitotic Prometaphase 363059 311802 306599 366403 29564 308870 29753 81740 192228 297522 29479 363055 305467 294010 29214 500069 692032 83572 290626 305882 309098 315423 171566 367153 314787 683722 360672 308064 100362495 362980 498265 311573 293844 313861 310344 311529 362203 287929 246150 300963 308663 252921 64462 680991 60347 290577 307347 304218 313304 25203 63996 684771 54237 305343 25515 94266 309179 299147 312754 29648 363174 64515 681185 297176 298594 114592 170845 305392 680089 308443 362519 303037 306464 362438 679342 296137 29167 291441 140734 24669 257649 257644 64041 287598 317252 307805 311191 114764 58945 500545 25448 305270 363028 286993 102555739 315164 114514 298850 681050 83836 295661 363198 304951 64158 684439 289150 361416 304477 65201 316531 296554 29213 56010 58822 315648 81650 294429 287830 363481 292085 287624 299850 252902 363193 29489 81738 24673 362548 683983 24672 116549 117281 85252 81655 299331 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%10230330 Activation of NF-kappaB in B cells 117262 85492 25023 287984 65138 94198 29673 50522 29671 84351 29670 29677 29676 29675 307366 192255 316241 81827 287280 83806 311078 361765 287772 292766 305584 100912032 81736 29669 29668 25493 29425 64156 100360846 309361 303024 117263 25581 29666 303353 309295 83477 365388 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%10228264 Aerobic respiration and respiratory electron transport 289950 298942 81654 81530 89813 288740 25309 292845 298748 293655 81728 291671 293453 81670 298147 691506 117098 293130 497902 299310 26195 499529 26194 171335 686506 654441 26199 303393 361385 26198 681896 84683 497863 681418 301011 26193 26192 289522 301458 300047 296658 64201 301416 299201 317444 297821 102550385 26203 26202 94194 300726 688386 681024 681913 362322 100188937 26201 362440 54322 360826 360229 366448 303922 289218 293114 304735 301427 25488 293991 25721 81829 313450 64539 25282 361520 309111 120097699 29445 360975 362495 24551 296190 362810 83529 293448 678759 294973 291103 100912357 315167 24401 85333 295143 362588 25708 296086 24860 361894 54315 685322 85263 102555170 690675 690354 25014 301123 56769 252934 499125 114597 157074 24368 24651 25104 114096 79250 26197 26196 362474 170587 363061 298596 361726 287069 310378 301624 289217 94173 362323 290985 64156 364686 245958 140608 300677 171082 94271 245965 300447 171069 29754 362749 641434 498226 690441 171375 192241 293615 65262 50522 171374 361596 24439 294320 24533 288731 298982 24534 83536 192255 307270 315949 246311 54705 361602 497900 302980 290705 369018 100912032 296849 311254 NEDDYLATION%REACTOME%R-RNO-8951664.1 Neddylation 304920 293023 287706 494223 360915 499114 171043 288921 688993 313722 367785 305792 292757 307200 316131 364050 360928 305895 290692 313020 100909827 245974 315405 313242 302502 688913 361219 309035 498005 360818 84607 25490 361907 688478 687364 363259 500616 499016 89829 685860 316228 309453 302288 314457 498559 298576 315745 29168 303602 291339 499807 362762 494320 310324 362566 311633 306750 317381 360860 363790 361181 303336 287367 498560 315723 311881 300950 117537 361268 316614 303792 300724 300849 117524 297592 316628 313445 306129 366854 303878 313101 362902 500587 81920 64041 361831 100362121 117152 24874 81807 29560 64345 641452 64525 29452 287772 292766 29669 29668 29425 64156 100360846 83712 117263 25581 29666 303353 365388 117262 85492 294790 287984 65138 293060 362093 361187 94198 29673 50522 363273 29671 29670 192351 29677 29676 29675 116643 84478 140639 192255 261736 353227 81827 83619 305351 363283 301674 287280 83806 311078 363284 500017 361765 64624 500262 100912032 301555 308999 304794 362081 310363 303024 313743 362511 498959 117039 100360914 503446 308283 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-RNO-9758890.1 Transport of RCbl within the body 29216 24565 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME%R-RNO-196741.1 Cobalamin (Cbl, vitamin B12) transport and metabolism 290947 314459 81522 29216 313520 80848 29319 362134 291939 24565 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622323.1 Presynaptic nicotinic acetylcholine receptors 25590 29422 25103 81721 54239 25753 170945 54240 171131 79557 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-RNO-9933937.1 Formation of the canonical BAF (cBAF) complex 368001 299186 361295 301020 361925 361825 287876 192352 293514 361711 303518 297867 VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%10231244 VLDLR internalisation and degradation 65046 50522 58851 298296 116563 306825 64156 140670 83800 192255 54241 100912032 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231622 Regulation of CDH1 Gene Transcription 302783 25705 24829 306945 81717 500569 303175 24828 689820 688041 297893 290270 313048 85489 309757 29382 64627 117056 690795 680498 83712 685909 680615 365877 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%10228708 Intracellular signaling by second messengers 294235 50557 361696 315093 79240 25267 24629 25660 81504 25408 25150 291171 500572 310306 79209 302415 313558 308875 84482 25266 116723 25443 296648 29348 24855 361388 170579 170633 309179 299147 312754 315189 310131 29183 24506 24505 140607 64022 24553 24446 314641 89812 25233 29613 287155 297893 83805 25433 25313 313050 365865 64156 311245 64030 315648 24329 363520 360471 50522 50689 363193 24673 192255 24672 309419 308051 117281 116590 100912032 25466 25467 117535 24890 29414 29149 361749 309361 29376 59325 58918 63879 81745 24185 25556 84477 83506 25149 81636 25238 294515 293508 302950 60427 64532 25521 25289 25622 25725 301059 29241 25513 85243 84420 24244 83571 170538 296988 64508 81742 25050 60664 24681 29699 24680 29340 60341 29691 170911 300177 366508 25489 100362346 310614 361724 290669 362834 64520 314850 294924 363875 246273 84489 361992 83504 66017 25444 29349 54250 25317 287772 292766 29369 291999 25022 29368 170700 116499 29669 29668 60662 60464 170583 81737 29425 289625 100360846 25114 25054 170582 25730 83712 24225 117263 25581 29666 81650 79114 303353 365388 29496 498596 432361 117262 85492 24827 298947 64545 497931 497932 287984 65138 313048 94198 29673 29671 29670 29677 29676 29675 307151 313038 309626 310258 303730 81827 294048 315136 24628 116549 83806 292887 311078 308869 310091 298514 501403 64226 295357 688041 297960 26954 117044 117043 56822 362045 56718 360776 59265 686412 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%10229650 RA biosynthesis pathway 307096 24188 170635 498789 266603 266686 500629 308190 313689 171516 116676 25061 297805 312495 24172 361266 685750 353252 291283 191574 360420 364773 498790 307092 VESICLE-MEDIATED TRANSPORT%REACTOME%R-RNO-5653656.1 Vesicle-mediated transport 289257 305614 64159 314251 81504 308458 83805 300678 25710 24932 24803 362862 500985 85491 64202 81803 294900 288785 364183 289312 295217 64310 64678 116743 317630 100362805 25306 89816 83730 83576 140673 25387 313409 192152 25319 362609 689256 25751 296199 312694 81659 24468 287709 361632 83800 641528 295171 54241 25151 683687 310746 363476 306332 117254 29292 192243 100360919 25388 24255 25081 64154 288700 365793 362283 500249 362162 361073 54350 315059 81732 363123 310839 24825 24827 65134 306229 113886 297428 287624 24942 120097389 304290 58842 363136 287873 363273 294286 299850 246294 81754 79434 81756 29489 58974 363266 366896 140932 289820 65277 24805 24186 64187 24807 64189 363283 317580 287645 316017 252853 171549 192348 311911 140940 29491 311919 65165 296649 65046 307868 316226 685144 29585 29584 81655 79214 29586 79217 690961 366311 363288 65178 266707 124461 116717 266706 687208 81645 363059 297518 365372 360915 29448 297995 295333 79117 29564 308942 303251 252889 304344 93646 314030 297522 29216 295461 114638 294010 292074 299825 309922 64670 289994 288669 64558 501854 114590 299799 114113 85256 290746 292925 290635 360827 290994 361916 94193 298598 94197 85248 54400 84393 287110 171121 290639 292944 313493 313254 315668 360956 360953 303575 290775 24648 287367 64462 314473 289309 266606 314349 89868 290659 691042 64351 300158 81922 313474 24855 313234 365191 116692 116691 312257 171575 681059 361705 498798 360854 499768 171574 171452 29183 192154 301012 25716 24506 24505 287427 310097 116561 81921 683007 116563 114023 302470 304978 116666 117513 100360302 311030 81824 81830 207119 29167 140734 58817 300147 64022 288779 303659 313340 306809 315999 58945 315756 54225 501550 360768 292886 292760 311494 25108 314641 29704 282834 117103 60355 361987 294709 293502 315740 25233 50563 50564 690252 360426 367073 84589 360797 266688 303734 100912115 64862 117548 299075 25218 315840 117550 360202 362983 312689 60384 289397 362502 300674 64630 300438 64633 291990 25423 64516 299121 140670 50592 309010 246310 117028 361308 363720 171291 25433 25313 64528 361555 171049 64156 309144 84357 84599 24221 171041 84590 287275 287276 25407 94189 140694 680465 246772 85238 24791 361207 24329 292994 25532 25531 117106 25655 361577 361697 84379 25530 84018 289350 361459 50522 293456 25183 29662 309451 252902 108348178 307039 361227 300888 286932 293344 192255 246117 685079 79120 79121 261736 79128 364981 252916 117051 294324 246324 29528 246209 310411 361244 29885 361120 309798 100912032 309678 300743 394266 56042 29414 296750 54226 311880 497913 367915 60668 117277 313934 60422 315111 117039 24464 314906 363677 25377 317396 312701 58917 689102 362237 503164 362599 306264 364419 503165 84403 59325 362118 363326 289168 60568 24185 311854 60566 60445 29753 29631 60564 60562 50645 24180 500906 252929 353302 24392 366618 84428 25238 83572 679886 363466 56084 25490 25372 363235 309523 25728 299858 100359675 94195 367308 64621 24440 360504 360922 25073 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 25738 25054 25730 24225 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-RNO-1660517.1 Synthesis of PIPs at the late endosome membrane 306490 288762 65052 307842 309855 363131 316457 361632 DEFENSINS%REACTOME DATABASE ID RELEASE 97%10230442 Defensins 286995 613220 613223 613224 286958 613225 641627 103690254 83687 641624 308873 290856 362347 25052 310553 641632 641636 641651 641650 24691 308163 641644 641652 641655 24932 641657 641656 305354 498659 641658 498658 683849 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%10228740 Formation of RNA Pol II elongation complex 689116 311796 298075 289561 305455 292778 679203 288651 266787 362479 361580 81807 294693 83503 117017 64525 291703 498109 363064 363633 293184 361531 81785 303281 301119 362110 303132 683469 114510 291705 300837 306261 304758 288588 266713 316123 502227 500715 690966 361365 304832 84389 METABOLISM OF PROTEINS%REACTOME DATABASE ID RELEASE 97%10228354 Metabolism of proteins 83614 682390 298700 690244 64514 691947 299872 293427 94168 288599 303831 288516 299899 171350 308306 299857 84491 260320 25373 25447 25329 24232 24873 407765 116740 364901 29237 29597 24450 25557 361676 116700 56816 25083 25087 60371 25653 363836 83505 316164 305291 365984 81726 308384 103689978 78973 304132 29316 690251 298071 310935 114711 24210 140593 291095 501167 293060 360475 361187 300668 362547 315212 311530 300089 192351 293587 302915 29403 303692 25280 301155 300741 305268 287920 299346 313231 298541 311847 353227 29758 295051 288525 305351 294400 301674 25128 363103 25040 304860 362031 363284 500017 64624 500262 308999 64631 362081 310363 313743 266607 362511 498959 100360914 503446 29468 308283 304920 293023 287706 494223 58983 499114 24179 171043 288921 83826 688993 313722 367785 24175 305792 292757 290692 100909827 361219 498005 360818 361907 687364 290744 685860 309453 24413 303478 25369 100909445 64202 362566 306750 363790 303336 291983 311881 171101 300950 54237 116698 689226 117537 361268 316614 303792 300724 300849 83474 117524 297592 316628 313445 81812 362859 306129 366854 24968 24967 361029 81816 29614 313101 314432 500587 24484 24577 292848 300320 25425 25672 84385 25737 25533 170583 24206 65155 361338 81686 287362 287876 307270 25615 497672 64557 290997 290631 316794 298534 287927 65158 297561 25573 308755 301442 499417 690043 302502 296099 295052 360748 114494 117282 308669 293719 289468 361181 362827 685059 362704 361286 29447 306257 25604 24205 79257 83422 361381 79210 29200 50554 81516 24504 81920 25671 363455 361831 296121 303743 114122 304832 24368 114096 79250 116484 170587 297893 362788 79224 313139 25268 29382 311204 304917 64156 116725 311245 309452 309295 24208 500133 116640 313121 362491 50522 684097 84478 140639 192255 29134 300837 83619 287280 308051 361765 100912032 360990 300445 25493 24890 312688 54226 24705 303024 315111 24919 290864 688466 503164 58851 315133 310375 313128 115771 312937 307503 301164 501145 304157 363109 288306 361190 297393 289950 498272 100361658 298942 297417 313427 81654 498486 310960 360518 308896 302488 302972 81759 290652 408217 363164 361495 304150 307905 60449 499801 362636 314453 297593 171329 294962 311856 293705 25154 288482 363084 298576 315911 360763 315639 83579 304798 24244 360860 362567 24400 361368 85471 311202 362520 299841 60349 493574 81667 257647 114489 308390 361014 298012 498560 293494 315723 29545 360853 65137 313304 304298 63996 316440 311026 362258 291737 116718 315523 64460 296084 85423 64013 114558 363658 54296 305581 29534 292406 100910143 25586 24257 114589 311169 81613 29142 83834 415062 83529 353251 54279 83532 691259 83531 309659 303878 266601 315807 366478 307992 362756 303277 288038 363060 304017 364032 304966 378774 207113 681194 313488 303923 117054 316583 288041 314180 305571 300017 362275 300653 287159 315075 363040 64442 292666 64445 360838 293667 100359675 293154 291132 24832 113910 316033 81506 316400 353304 313536 29640 681033 296394 494342 79112 362924 29561 297406 502017 65196 116597 60378 25295 362133 50692 81716 60333 29417 117522 541462 362934 363104 367308 300027 64621 295543 29189 116658 59318 59313 690037 50864 312806 313216 192263 60351 691120 310856 25627 66015 25591 29240 287772 292766 29669 85253 29668 29425 100360846 54281 83712 117263 25581 29666 81650 25353 303353 365388 304135 266712 300338 117262 297337 85492 362412 308282 295568 24829 293561 500636 306945 287984 307029 24828 116510 286761 65138 100360606 362093 363982 94198 29673 29671 29670 266670 29650 29677 29676 360665 29675 116643 680615 290638 365877 63864 81827 116549 83806 171565 311078 292485 24259 25307 29461 83476 308807 688041 303635 289525 301555 25434 63878 680692 313954 64627 25277 361755 84595 304334 360622 304794 338474 25685 362182 83727 286906 298683 79110 25285 292905 83477 29160 24765 56646 50557 689404 25376 289257 305614 64159 314251 116696 117523 308458 292845 302415 293655 291671 60331 293453 360847 497902 29215 26195 26194 26199 65044 26198 292325 102550196 313233 83627 308440 102554393 26193 299314 26192 315728 171133 361142 499968 301458 474348 497227 291958 306664 64043 299201 367384 286971 307838 26203 286976 26202 315263 94194 29750 313878 362760 497619 171569 25618 304571 26201 297757 64456 500032 314655 685758 170501 294809 364630 362539 309114 308787 361886 100360475 81829 293004 288611 120100673 64539 310670 100361647 361412 312566 690914 360975 315879 311952 365699 311039 361332 300474 293448 302499 300475 296290 24399 25014 252934 29611 117152 171152 25176 293345 292588 691517 296368 64632 302813 266758 60627 64550 361100 83711 299957 171455 367846 116654 24818 313961 50556 302668 691688 245709 363269 288305 294075 361645 294864 266704 293528 293142 102551929 295230 303310 25196 54242 29374 293967 301265 298692 170897 292311 24715 690512 25608 306515 311548 24310 689746 299809 315214 64017 25204 362415 305470 24391 24590 362154 113965 100137086 59301 117273 308976 252881 314300 113902 100362554 302526 288923 64549 310261 25253 303755 24482 305287 287444 498034 25747 170818 314644 309153 361925 294698 116722 100361517 83499 288455 296651 299903 299156 310632 171058 360571 305853 500088 171122 100364984 503269 81755 85237 171111 367242 689377 140665 309649 302931 102553119 689197 361664 316976 315134 24498 292876 29144 361749 25094 79438 24594 290257 25662 680415 25641 362862 688685 307350 353231 83501 310207 297376 170916 300786 307200 316131 364050 360928 305895 313020 245974 315405 313242 688913 309035 84607 688478 29539 363259 500616 499016 89829 316228 302288 314457 25506 498559 315745 29168 303602 291339 499807 362762 494320 310324 311633 317381 29591 64310 64515 59107 114592 140673 25387 192152 64041 24468 287709 100362121 500545 309441 24483 303746 192243 295238 293054 309176 298517 291685 26200 293754 297799 24874 81807 361883 690345 29560 311903 363023 64345 641452 301552 299628 64525 29452 497876 686234 26197 26196 683519 315141 306886 288916 25388 294230 25700 309140 100363539 302973 360594 500199 24255 299938 292758 287962 295224 296551 54318 171061 292244 363646 116650 689432 361473 361005 310653 362216 296302 297601 56281 309440 287656 25081 297459 301250 301371 364656 299027 287302 293666 114017 296134 303685 64154 363445 288700 25631 64360 365793 113958 294767 500249 684304 680747 362162 361073 29357 301352 54350 290850 315059 297372 301240 363123 498406 303539 24825 24827 300677 65134 94271 297428 363287 24942 641434 304290 58842 363136 192241 65262 171374 363273 299850 363064 293184 361531 81754 79434 81756 29489 63868 503049 24186 50559 363283 317580 64526 113936 24233 252853 406161 312703 140940 65165 680424 685144 81655 79214 314304 690961 89842 360915 29448 79117 29564 252889 93646 314030 297522 295461 291171 294010 500572 292074 310306 289994 501854 299799 50866 287899 290994 94197 54400 305253 171121 315668 24648 287367 64462 89868 290659 64351 300772 361705 63880 498798 29183 301012 24506 24505 287427 683007 114023 302470 304978 116666 117513 100360302 311030 81830 29167 24946 140734 58817 366061 288779 29243 58945 54225 501550 117103 60355 690252 367073 84589 266688 100912115 299075 60384 300674 312199 64633 316091 287119 291212 291990 306549 293408 25423 84430 315769 299121 688673 294754 289508 498402 50592 309010 246310 117287 29565 362191 64528 295394 171049 309144 304579 84599 84590 287275 287276 25407 316342 64646 94189 305348 365314 680465 502125 89820 361207 294790 25532 25531 360471 361577 25227 84379 311013 25530 316642 303631 293456 117185 315222 309451 24800 252902 365619 307039 310326 362409 300888 307404 246117 29481 79120 261736 252916 299521 246324 310411 309678 300743 56042 367915 26295 362414 117039 689102 362237 362599 306264 503165 29631 50645 252929 298079 84428 56084 25490 171102 25498 291434 81729 288617 25347 25649 29304 25348 25728 28298 65136 27139 64205 26962 294282 140638 683630 100910714 681429 117053 100362640 64298 161477 290641 94266 24773 246326 245977 140654 25548 25350 140655 314799 170568 60373 494021 50683 361923 134480579 29300 84395 192155 117042 287122 499782 103689992 140661 29258 140662 29257 362902 64520 300079 292964 25236 293418 81768 100361974 81775 81776 362631 360572 81773 81774 245981 497860 81770 293725 691531 64640 363241 171361 83789 300033 24375 81764 291325 140808 81765 25478 81766 122799 25197 303100 308757 81767 29236 65271 362625 81763 367252 295319 25547 100361060 29582 299756 81519 58927 94273 140568 432392 689284 100361756 29288 29287 29286 29285 124323 24367 29284 29283 29282 296709 287662 64302 64306 100360439 64307 122772 134486107 294429 500152 287830 291874 362281 113975 292085 445442 295692 117021 362335 366016 58958 361596 362557 65274 113929 117099 690163 116635 245922 81738 307151 683983 313038 53372 171154 309626 25497 306608 499974 310258 303730 24842 501403 116636 117044 298296 117045 292762 362952 192234 108348073 292148 300069 293484 171145 117019 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 97%10231446 Biosynthesis of DPAn-6 SPMs 287454 81639 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-RNO-9933947.1 Formation of the non-canonical BAF (ncBAF) complex 368001 292622 296732 83833 361295 301020 361925 287876 192352 293514 301235 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 97%10228584 Transport of Mature mRNAs Derived from Intronless Transcripts 287830 291874 362281 689116 113975 681062 298075 292085 295692 117021 362335 299256 366016 58958 289582 362557 65274 113929 297522 245922 81738 683983 53372 25497 59087 499974 690585 117045 304277 294429 IMMUNOGLOBULIN MATURATION%REACTOME%R-RNO-9938026.1 Immunoglobulin maturation 309812 24984 294273 316235 81685 288003 290644 293502 116468 315740 29448 81709 289168 50654 399679 25737 29564 294339 288414 25697 29175 305000 353302 294010 117550 84428 25423 299121 361308 85248 84393 294269 24981 64156 24986 171041 314473 287624 50522 299850 252902 29489 192255 171549 29167 100912032 140734 316226 287531 289758 316344 81655 25424 58945 296320 259221 25425 89809 313702 314906 365542 684529 361704 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231284 MET activates PTK2 signaling 360606 25614 309816 691517 170921 24511 24553 24446 83805 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%10228688 phospho-PLA2 pathway 116590 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%10230064 Zinc transporters 305846 295455 58976 294281 314637 299903 361986 300051 291733 306009 294698 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-RNO-975576.1 N-glycan antennae elongation in the medial trans-Golgi 313536 494342 65196 24375 291325 25478 25197 303100 303923 308757 117523 65271 367252 362275 25547 363040 29582 299756 94273 140568 432392 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%10228816 Activation of BID and translocation to mitochondria 171528 259274 64044 64625 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%10229224 Removal of the Flap Intermediate from the C-strand 307798 307861 59294 84490 289758 290805 25737 290232 59102 297758 361698 500054 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-RNO-399721.1 Glutamate binding, activation of AMPA receptors and synaptic plasticity 140724 84591 140725 60355 25023 25400 84016 25252 84347 315840 24245 24246 59317 29495 116563 171140 140670 50592 29629 29628 29627 65046 363447 171571 140729 24681 24680 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-RNO-202733.1 Cell surface interactions at the vascular wall 24605 25544 293621 360918 89807 89805 81504 24525 25528 25150 100360919 313845 25738 309684 25651 300519 81683 84427 499099 362248 24511 25622 25513 81515 85243 83805 25268 313050 140914 58844 116479 25518 85385 65200 80878 50719 25027 116689 116726 83509 29364 25650 84551 499271 360606 307811 50687 25390 300338 25246 65037 25406 170911 29583 29476 29302 360922 29409 296456 81613 171577 25599 296269 308995 315509 64025 245962 50567 89843 301229 54225 363930 83580 54259 619374 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 97%10230272 IRAK1 recruits IKK complex 84351 363520 309361 305549 116725 311245 309157 309295 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%10231594 LDL remodeling 25506 310900 DEGRADATION OF GABA%REACTOME%R-RNO-916853.1 Degradation of GABA 81632 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-RNO-428559.1 Proton-coupled neutral amino acid transporters 155205 246235 ENOS ACTIVATION%REACTOME%R-RNO-203615.1 eNOS activation 24244 25514 64157 24600 170520 298184 29270 299331 24185 80773 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-RNO-8963889.1 Assembly of active LPL and LIPC lipase complexes 24539 25507 300027 54281 100361444 116548 315218 362850 502970 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-RNO-69202.1 Cyclin E associated events during G1 S transition 58919 117262 85492 24708 294790 25233 287984 24185 65138 94198 29673 50522 29671 29670 29677 29676 362485 29675 192255 499655 81827 366275 287280 83806 295052 311078 287772 171102 292766 94201 100912032 307585 308937 29669 83571 29668 114494 29414 29425 64156 100360846 266713 117263 25581 29666 303353 365388 84389 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-RNO-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 24968 24967 85492 29614 94198 29669 29673 29668 29671 29670 29425 100360846 29676 29675 29666 291983 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%10230636 Abacavir metabolism 100363253 24172 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 97%10230070 GP1b-IX-V activation signalling 502858 25259 116727 25578 24703 25513 83805 691992 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 97%10230682 Scavenging by Class A Receptors 25081 362862 25728 54225 64202 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 97%10230632 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 502969 25426 29277 313375 24296 24297 65030 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%10230796 RIPK1-mediated regulated necrosis 64044 63879 311567 50522 64665 56816 246240 305549 266610 306886 83764 246097 117279 25385 690743 192255 501083 246756 60371 363836 287155 83841 100912032 64156 26295 299331 114562 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 97%10230134 TRAF6-mediated induction of TAK1 complex within TLR4 complex 60350 362418 29260 308267 287545 313121 100912032 317546 364867 448830 50522 64156 311245 192255 363328 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%10230954 RHO GTPases activate KTN1 316226 64465 361029 171549 117550 171041 363875 314906 117273 308875 CARNITINE SHUTTLE%REACTOME%R-RNO-200425.1 Carnitine shuttle 25682 25757 25413 64562 29726 373545 404280 25756 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 97%10231182 Intra-Golgi traffic 60355 64351 65134 116692 116691 293456 314030 60562 367308 500906 64621 65277 64310 291990 64516 310411 140673 54400 313493 315668 64154 365793 690961 362283 100359675 361073 94189 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%10228138 Synthesis of DNA 313138 313479 299112 298098 288003 292071 362385 312538 116468 291927 360621 304573 25737 362304 301430 288414 85241 366381 292588 293155 296368 361389 288671 290875 362485 305420 360643 59294 84490 295052 287772 292766 29669 29668 114494 29425 64156 100360846 117263 25581 29666 303353 365388 361698 117262 85492 294790 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 100912032 289758 361831 301323 288532 89809 316273 292058 59102 295596 307639 296178 499914 290842 29728 SCAVENGING OF HEME FROM PLASMA%REACTOME DATABASE ID RELEASE 97%10230646 Scavenging of heme from plasma 503164 24440 360504 299858 25081 360922 100360919 315111 24464 25377 312701 24186 58917 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%10230852 Mitophagy 192647 641452 50522 246294 56816 64862 288731 362245 361321 192255 363442 365601 363836 83529 116549 83532 299827 83531 299514 266601 360827 298575 685620 363254 300075 308416 304017 113894 100912032 83805 81920 64156 116725 81650 SIALIC ACID METABOLISM%REACTOME%R-RNO-4085001.1 Sialic acid metabolism 316033 362924 298071 114711 316642 291325 117185 25197 311530 116696 117523 303692 407765 25547 25280 301155 287920 29758 83505 363103 304860 313139 365984 363040 364901 64442 64445 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228256 Galactose catabolism 313843 298003 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%10231296 MET interacts with TNS proteins 303517 24511 24553 24446 DOWNSTREAM TCR SIGNALING%REACTOME%R-RNO-202424.1 Downstream TCR signaling 50557 81745 641452 307366 287772 25513 292766 85243 294269 29669 300678 29668 313050 25300 29425 24981 64156 100360846 25710 24986 24932 116725 117263 25581 311245 29666 303353 309295 365388 117262 85492 170911 287984 313121 362491 65138 94198 29673 50522 29671 84351 29670 29677 29676 29675 192255 81827 287280 83806 311078 308267 361765 100912032 81736 25493 309361 361831 303024 54259 83477 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-RNO-5675482.1 Regulation of necroptotic cell death 64044 63879 311567 50522 64665 56816 246240 305549 266610 306886 83764 246097 117279 25385 690743 192255 501083 246756 60371 363836 287155 83841 100912032 64156 26295 299331 114562 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%10229846 Orexin and neuropeptides FF and QRFP bind to their respective receptors 500157 60337 25723 379044 310327 25593 78964 25605 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-RNO-6811440.1 Retrograde transport at the Trans-Golgi-Network 363123 60355 120097389 84379 84589 293456 314030 60562 25218 286932 309922 293344 312689 685079 65277 64187 364981 291990 117051 29528 310411 140673 309798 311919 296649 192152 313493 367915 690961 362283 500249 361073 25151 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%10231652 MITF-M-dependent gene expression 361604 312451 690660 50645 360034 84353 25094 161452 25017 297893 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%10231438 Pre-NOTCH Transcription and Translation 84006 304815 TRIGLYCERIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%10228524 Triglyceride metabolism 300108 80841 79223 362732 296130 316737 681211 29653 84497 252900 499570 24360 25440 25598 79131 25062 140868 64822 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition 83836 117103 64158 311802 306102 366403 316531 29753 81740 192228 29479 296554 85265 363055 29213 305467 294010 29214 500069 83572 290626 305882 315423 367153 314787 683722 360672 308064 100362495 311573 293844 310344 56010 311529 58822 64156 246150 300963 304813 252921 116670 64462 60347 307347 25203 54237 25515 50522 299850 246294 29489 192255 25594 287280 117281 361765 29167 100912032 311191 114764 58945 303024 299331 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-RNO-5696397.1 Gap-filling DNA repair synthesis and ligation in GG-NER 59294 299112 171525 298098 288003 362385 116468 25737 304573 288414 100912032 50522 289758 64156 89809 59102 192255 361698 MAPK6 MAPK4 SIGNALING%REACTOME DATABASE ID RELEASE 97%10229860 MAPK6 MAPK4 signaling 64551 117262 360635 85492 54237 84009 58840 310806 287984 65138 94198 29673 29433 50522 29671 29670 29677 29431 29676 29432 29675 363875 25193 192255 294515 293508 84482 81827 309175 64465 83806 311078 287772 292766 100912032 29669 29668 29425 64156 100360846 85252 117263 313838 25581 29666 303353 365388 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 97%10231356 G beta:gamma signalling through CDC42 294962 64465 83579 363509 680149 58979 64199 114117 24400 79218 29431 81667 245986 60449 ORGANIC CATION TRANSPORT%REACTOME%R-RNO-549127.1 Organic cation transport 24904 29504 50662 29503 360539 309131 362403 54302 54301 310732 29726 64037 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-RNO-5654699.1 SHC-mediated cascade:FGFR2 24605 66017 293621 25444 25443 29349 29348 54250 25317 170579 29369 170633 25022 81504 29368 24525 170700 116499 60662 60464 313845 170583 85385 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%10230468 Acyl chain remodeling of CL 363521 362702 171155 170670 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%10231330 Regulation of PTEN gene transcription 315093 313048 294924 307151 313038 309626 310258 303730 315136 100362346 308869 310091 298514 501403 310614 64226 295357 361724 297893 290669 688041 362834 64520 297960 26954 117535 117044 117043 362045 56718 360776 83712 686412 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-RNO-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 59324 116491 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228514 Wax and plasmalogen biosynthesis 293173 302425 84114 287380 84470 679520 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%10230338 Antiviral mechanism by IFN-stimulated genes 25738 170897 25498 313017 64511 292892 25318 54281 116725 315648 309295 306231 359726 304545 54237 300955 362678 362050 298693 54287 691105 25125 306204 114558 24667 50689 63880 84351 499155 81746 24472 304859 312754 304266 291978 24649 24673 25489 502320 287876 303742 314172 84472 114495 171164 311430 24672 29219 24842 24963 295704 501552 117281 81822 60460 311130 363006 312688 309361 24468 117063 81635 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-RNO-5610785.1 GLI3 is processed to GLI3R by the proteasome 117262 85492 287984 65138 94198 29673 50522 29671 29670 361769 29677 29676 29675 113927 192255 140588 293508 81827 287280 83806 311078 84027 361765 287772 292766 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228326 Carnitine synthesis 64040 170898 64564 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 97%10231160 Regulation of PTEN localization 50522 50557 64156 25489 63879 360471 192255 100912032 PROCESSING OF SMDT1%REACTOME%R-RNO-8949664.1 Processing of SMDT1 298203 114766 64198 301418 688685 287979 295462 307350 171433 353231 365567 25344 364601 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 287280 83806 311078 84027 361765 287772 292766 100912032 499342 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%10228188 p53-Dependent G1 DNA Damage Response 117262 85492 114212 287984 65138 94198 29673 50522 29671 29670 29677 29676 362485 29675 300711 192255 81827 24842 83806 295052 311078 287772 292766 100912032 685474 311575 29669 83571 304798 29668 360860 114494 29425 64156 100360846 117263 25581 29666 303353 365388 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-RNO-8948216.1 Collagen chain trimerization 499431 85490 315071 84032 353303 314981 312115 60379 25681 685612 304021 294279 25412 301012 25654 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-RNO-9013973.1 TICAM1-dependent activation of IRF3 IRF7 292892 293624 IMMUNE SYSTEM%REACTOME%R-RNO-168256.1 Immune System 25441 89817 360509 25528 24795 29385 305234 84491 81683 25096 308875 292409 499099 25373 362893 314618 54258 24232 25097 81503 308163 84007 29738 25524 56816 306871 361467 25087 60371 304822 363836 287155 690158 353316 445269 362249 24159 311821 246358 311373 24812 140593 293060 362277 361187 687633 315608 50558 361866 192351 360534 316395 317241 362294 315863 29274 305268 140939 303963 295252 316005 353227 314613 313525 305351 301674 303735 295704 363284 500017 64624 299197 498726 500262 117553 140941 308999 60383 306417 289437 64631 310461 155812 64517 362081 310363 313743 362511 498959 100360914 503446 29468 308283 302987 288596 304920 308968 293023 24223 287706 494223 685029 362087 499114 171043 619577 288921 688993 313722 309591 367785 363188 305792 292757 498011 360926 301515 361383 316575 290692 100909827 683077 282845 312647 361219 498005 360818 361907 687364 302938 685860 309453 690769 171136 113959 500532 680842 303478 100909445 306505 64202 94196 500511 362566 306998 306750 303689 296988 363790 24750 652955 502852 311866 313806 308901 25617 303336 291983 313264 297961 311881 301042 362900 58949 300950 291597 295279 54237 689226 25023 117537 24974 361268 316614 303792 499400 300724 300849 117524 311567 300968 24988 313115 297592 362367 316628 499877 364681 298689 25489 313445 291755 192256 365527 362377 362376 309758 362814 362859 306129 366854 24968 24967 367167 81816 29614 313101 501546 314432 81815 171105 296161 500587 302934 287531 289758 316344 25424 296320 291759 259221 25425 89809 313702 365542 684529 361704 309812 24984 294273 316235 81685 288003 290644 116468 81709 50654 399679 25741 25737 294339 288414 25697 29175 305000 295378 81511 292804 100360919 25060 25738 24189 29337 29431 29432 366962 363875 24191 24511 24642 63865 25518 684440 361689 317468 315707 24206 306231 359726 304545 24699 298947 25374 64545 497931 499415 497932 289032 81687 300732 29433 117514 282817 360557 290408 29192 287362 58923 287876 315949 64465 81822 83841 301005 54227 289231 362329 363247 64046 287927 301442 29214 311860 314787 314336 308669 500538 25019 309179 299147 304859 312754 499069 84353 311130 363006 690516 81920 361831 497811 24697 24434 117063 117538 309014 289211 259242 310178 79113 361527 65261 367901 25017 361378 116484 310864 83782 296654 690945 291359 296321 680127 287545 246116 252961 362788 64156 25095 25742 81647 116725 290029 314322 311245 315648 363328 361929 309452 309295 499271 81771 311396 310877 292072 117269 500133 353218 302424 306600 60350 365581 363520 29260 156767 293624 25069 291921 117516 64044 296872 300447 25008 25625 313121 362491 683163 287707 500592 25572 363855 364867 25341 25272 89814 498666 50522 50689 500590 498769 84351 252878 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 25599 116596 297596 24672 116554 287280 362418 300980 29692 308267 117281 361765 50658 116590 291861 100912032 317546 81736 448830 25493 312688 116663 54226 309361 60587 303024 299331 24464 24835 312937 81745 361810 306956 306957 684480 301252 288375 294515 293508 29684 679787 25110 498888 24244 170538 29511 140868 29340 432363 298693 54287 246244 306204 114558 24667 502902 362432 64171 450223 64537 24257 81613 29142 304017 304966 94167 292666 293154 294673 316033 81506 292073 29681 94195 50692 100360623 59313 116547 690130 65197 289874 24691 287772 292766 29543 94201 290783 65248 29669 29668 499285 362040 56010 29425 100360846 116967 54281 83712 117263 25581 29666 29153 81650 315606 303353 365388 299606 683849 290829 291000 58919 290823 302783 117262 85492 192275 407784 25406 64562 24829 306945 24153 287984 103690254 24828 65138 362093 313048 94198 29673 100188932 29671 362347 29670 63849 29650 117056 29677 25052 680498 29676 29675 498840 116643 24934 685909 24931 680615 24930 309304 498079 290638 362046 365877 686092 310727 308417 301626 81827 316241 294048 25520 308501 116549 83803 54266 83806 308995 311078 298702 292485 498287 84027 287818 313648 25307 362891 353253 100913063 303175 499356 373545 688041 305584 363160 304349 689853 301555 499342 364049 287643 474146 171369 64701 56822 64627 690315 89843 684984 690795 360967 499537 304794 25713 361710 301229 100361633 360640 361618 360647 25109 363024 83477 25464 293618 50557 25103 689004 313644 305311 361400 84349 24605 313785 292844 293621 292843 292846 29221 64159 407756 307199 25660 361673 25408 81504 288244 24525 25614 100910497 25066 25150 680844 300649 313845 362443 312711 309684 305081 24683 307366 25235 363577 574531 24684 25361 293130 299314 25035 83578 315085 24618 310553 499925 499926 296290 641632 641636 641651 641650 24620 246238 24941 299567 171162 641644 84355 685161 100361909 310611 314615 641652 641655 84387 641657 641656 305354 498659 301034 641658 498658 29748 316010 117152 286995 613220 613223 613224 100361818 286958 296354 613225 641627 24674 25400 311558 50585 24675 83687 305842 170496 691149 493810 641624 308873 290856 366381 361795 292588 500910 296368 360548 315435 361389 288671 290875 305420 360618 360643 58970 288305 170897 299809 24391 24590 81515 117273 83805 295338 294269 302526 64511 300678 313050 361171 25300 24981 25318 25710 24888 24986 24932 360697 24703 116465 25712 305355 24514 300250 316519 64314 317676 25316 25047 293118 58940 64019 100364984 361537 24599 24598 301512 24600 140665 25262 54286 309649 304987 113894 25466 24498 25467 29144 689932 24493 690369 361749 79130 100911249 688621 54245 24918 303604 25325 25326 54259 116470 24803 65038 290257 314870 25578 25216 29376 362862 362629 362628 317553 117022 362077 498951 155140 287942 25556 500836 310132 84477 25670 361677 171081 313173 117284 25402 500985 296541 25084 688622 29201 24245 24246 84388 365368 287287 373540 500616 89829 299827 84492 680609 25506 171140 85491 25622 25746 116690 301059 291339 25513 311783 85243 81680 681112 116630 290655 25613 25734 444986 685840 682457 60664 85385 25704 100361814 25707 688730 100361294 29143 116689 81802 304284 363127 81803 81804 56780 259275 84405 171334 500361 171333 445415 499157 245983 116558 690906 317335 304091 306324 116562 290923 29197 100125364 170911 64185 25155 50646 303180 300177 308632 497195 25125 291091 25126 81641 365769 116553 295214 29205 499744 289747 474169 360914 362638 170819 306760 366508 287721 171106 25012 498128 498234 60582 64681 301365 84397 84398 304692 291854 290409 304543 192177 85274 25739 302495 500324 64310 298792 64515 684322 116743 298682 266775 304988 100362805 288778 58826 83730 303542 192264 291948 24251 292537 29714 83462 25319 362966 361635 25751 293753 25328 84586 288174 295706 24468 287709 25455 302890 83800 450222 360445 25308 54241 289318 361422 25151 64527 314843 690263 306332 298066 29292 315916 89824 362431 363522 313837 300857 25046 25679 29521 25505 24874 378947 81807 170923 81678 246272 83799 83781 641452 246250 29665 64525 363463 113940 366988 246240 266610 297932 363131 306886 298103 246273 29757 289407 361992 362802 65052 368044 296981 298451 299971 170667 436582 498416 297566 312488 117596 94170 116664 366545 300813 81732 287624 299850 246294 29489 289820 65192 64189 155012 113936 24233 298566 406161 171549 64459 24854 24237 24479 29687 365466 58857 114091 362634 25419 65046 295703 64023 316226 64668 685144 54243 79126 81655 117512 29333 24248 312705 192262 501072 299928 289395 303861 297518 29448 29564 297930 93646 297522 295461 294010 79209 299825 288669 50866 294329 94197 85248 315272 84393 24648 314473 89821 300955 679934 296648 305896 362678 362050 286928 691105 100911527 117542 690894 310968 300772 63880 499155 60352 81746 360854 24472 296456 171574 304266 315189 291978 24649 310131 79249 502959 24481 502320 303742 79129 66021 120103159 294568 287427 120103158 314172 315348 84472 81679 171164 298205 116563 311430 308666 686326 362271 114023 29219 313024 24963 298210 501552 58823 60460 682937 501570 288264 81824 246280 29167 140734 58817 295347 288779 58945 54225 367562 64035 81675 362029 293502 315740 25233 360426 117550 287610 64630 25423 299121 289508 140670 56011 313017 361308 29565 84357 171041 287275 287276 25407 140694 84497 294790 25531 363494 361697 25227 84379 29662 315222 252902 307039 84431 246324 29528 29414 367915 314906 78963 58918 289168 24185 50645 252929 353302 24426 84428 25551 25498 292892 299732 25290 171341 24856 307833 171361 24375 296554 24440 24366 24367 29434 59326 171337 361714 140914 24944 79239 54249 309147 29364 29583 291085 306761 305679 140656 24614 56611 29186 24842 25639 308869 64226 306825 362045 56718 681544 24917 81635 312562 SIGNALING BY RETINOIC ACID%REACTOME%R-RNO-5362517.1 Signaling by Retinoic Acid 25682 307096 266603 266686 308190 289950 298942 81654 24172 361266 81530 89813 353252 364773 498790 117098 24188 170635 498789 500629 29563 313689 171516 296849 116676 311254 25061 83574 297805 312495 24705 685072 685750 140868 291283 191574 360420 307092 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975956.1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 81773 81774 689116 245981 298075 501582 497860 81770 24420 691531 64640 171350 83789 81764 684558 307503 81765 81766 122799 81767 29236 81763 100361060 58927 689284 100361756 29288 29287 29286 29285 124323 29284 29283 29282 296709 64302 64306 291434 81729 100360439 25347 64307 29304 64156 25348 28298 122772 65136 134486107 27139 64205 26962 294282 100910714 681429 117053 100362640 64298 161477 290641 50522 94266 140654 140655 361923 134480579 117042 287122 499782 103689992 140661 29258 140662 29257 300079 292964 293418 81768 100361974 81775 81776 362631 360572 PROLINE CATABOLISM%REACTOME%R-RNO-70688.1 Proline catabolism METABOLISM OF FOLATE AND PTERINES%REACTOME%R-RNO-196757.1 Metabolism of folate and pterines 29723 24312 299699 64392 300886 680308 303333 362657 64300 299857 305248 361472 293154 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190239.1 FGFR3 ligand binding and activation 66017 25444 29349 54250 25317 29369 29368 116499 366061 60662 60464 170583 84489 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%10229214 Glycosaminoglycan metabolism 25216 246232 299825 294449 688293 293451 64537 295430 360630 84406 364476 108349781 303218 302489 292155 29633 363618 114002 368128 684979 299907 691984 171517 291577 116673 24771 291770 297554 500257 295934 300757 304322 302302 317322 291015 25236 301525 286974 365583 303923 316583 297865 58920 305571 314694 25592 316533 84400 362275 361450 84468 363040 64442 404783 300993 64445 293667 367166 367145 24434 81651 307859 266805 294673 114122 314771 50568 25181 316033 292073 363513 64507 313536 500961 298690 494342 362924 81682 58968 65196 25694 25697 315939 64152 116721 294103 295443 304885 282821 500052 306866 25393 360670 117267 25406 25227 29139 24782 290638 25615 363103 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-RNO-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 60350 299827 29260 252961 362788 100912032 364867 448830 50522 246294 64156 192255 363328 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-RNO-5578749.1 Transcriptional regulation by small RNAs 302783 289561 292778 686774 24829 306945 303175 24828 83503 117017 84509 64627 498109 363633 117056 690795 288588 680498 308971 685909 680615 690966 361365 365877 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-RNO-975144.1 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 84351 363520 309361 305549 116725 311245 309157 309295 TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling 296269 24605 293621 25622 170911 25513 89807 89805 85243 81504 24525 313845 58844 85385 84427 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-RNO-445095.1 Interaction between L1 and Ankyrins 50687 308458 289257 305614 64159 314251 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-RNO-9634638.1 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 83571 29414 246332 85252 25233 24185 116590 294515 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-RNO-9855142.1 Cellular responses to mechanical stimuli 29597 25026 117104 24185 81745 25029 64199 25614 79218 24627 245986 60449 293508 66026 294962 311860 25521 24511 58966 25725 83579 680149 58979 24244 114117 24400 29156 81666 81667 29154 29699 315648 81662 309295 296648 29302 305679 84351 296456 315189 310131 363014 56611 24672 24600 117281 64226 81736 25493 56718 309361 24697 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229062 G-protein activation 294962 25601 83579 680149 58979 64199 114117 24400 79218 81666 81667 245986 81662 60449 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 97%10228972 Telomere Extension By Telomerase 307798 307861 306264 295052 287432 297483 170944 171121 114494 499709 367645 691534 301965 309144 362288 287273 290232 297758 500054 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 97%10231222 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 297593 363836 360847 81816 689226 314432 303478 100909445 360471 100912032 100362554 641452 50522 292588 64631 296368 64156 361831 363445 305268 192255 498560 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-RNO-3371556.1 Cellular response to heat stress 116456 81800 500907 25400 366734 171361 29734 29753 297522 301252 24245 24246 291671 362809 260321 171140 309757 25617 294429 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 50689 65274 113929 289014 24472 245922 81738 116643 683983 53372 25497 499974 24963 292887 286899 362293 84027 60460 64226 116590 293524 25420 307997 297994 311427 56718 690038 24468 266759 293103 299331 79245 288444 59102 307133 113906 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%10229162 Classical antibody-mediated complement activation 25419 100360919 298566 312705 192262 29687 362634 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance 25081 314459 80848 25073 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 97%10230552 IPs transport between nucleus and cytosol 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 294429 499974 RHO GTPASES ACTIVATE CIT%REACTOME%R-RNO-5625900.1 RHO GTPases activate CIT 64373 29495 83620 308761 360849 363875 117273 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 97%10231136 Signaling by MST1 292770 29135 311331 MIRO GTPASE CYCLE%REACTOME%R-RNO-9715370.1 Miro GTPase Cycle 287156 192647 171086 497974 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 97%10231306 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 310258 303730 296732 116549 315136 83833 681178 301020 361925 501403 361825 50662 361391 307151 288563 313038 81650 309626 303518 297867 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells 84482 29414 25233 24185 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines 117262 85492 287984 65138 94198 29673 29671 29670 29677 81640 29676 29675 84596 298607 689588 24314 81827 83806 311078 287772 292766 29669 24609 29668 25502 308652 29425 100360846 117263 25581 29666 303353 365388 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-RNO-426048.1 Arachidonate production from DAG 309207 29254 499913 305795 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 97%10228506 RNA Polymerase II Transcription Initiation And Promoter Clearance 170844 83830 171152 309638 289561 292778 288651 288533 373541 293345 294018 361580 303918 117526 294693 83503 117017 291703 498109 363633 287571 288588 266713 291773 316123 317256 502227 83828 690966 361365 81673 84389 ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 97%10229854 Alpha-oxidation of phytanate 65192 65183 114209 113956 85255 APOPTOTIC EXECUTION PHASE%REACTOME%R-RNO-75153.1 Apoptotic execution phase 292994 64044 64159 83502 298534 307562 25614 24205 498072 25402 306871 291755 84353 361092 83497 116685 60371 24170 291145 304822 64026 317589 296654 81818 305884 24437 680522 84359 201097 316164 367786 684828 114114 170538 25318 24917 RHOH GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%10231406 RHOH GTPase cycle 305341 29448 117955 311450 360500 81522 362456 360678 29431 29432 292756 303888 116643 500929 81679 315732 64678 25537 29528 308869 313050 29611 56785 689997 315707 83809 498174 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%10231126 Neutrophil degranulation 25441 25103 24605 292843 292846 64159 29221 360509 25528 24795 29385 309684 305234 84491 574531 81683 25096 308875 292409 499099 293130 25373 362893 314618 299314 25035 54258 24232 83578 315085 81503 310553 84007 100361909 314615 84387 498659 301034 498658 316010 286995 117152 613220 613223 613224 286958 29738 613225 170496 290856 25524 306871 360618 361467 58970 288305 304822 299809 690158 24590 117273 302526 361171 362249 24159 311821 246358 300250 316519 293118 100364984 361537 140665 309649 79130 290257 24223 361677 117284 361383 312647 113959 680842 116690 291339 306998 24750 100361814 688730 29143 116689 304284 363127 56780 259275 500361 445415 58949 499157 690906 317335 306324 290923 24974 100125364 64185 303180 308632 499400 497195 291091 81641 29205 24988 474169 360914 362638 306760 287721 498128 25012 498234 64681 84397 84398 291755 304692 291854 365527 290409 304543 192177 85274 25739 362859 302495 500324 298792 684322 298682 266775 100362805 304988 288778 501546 58826 83730 303542 192264 291948 24251 292537 29714 83462 25319 362966 361635 293753 25328 84586 288174 295706 24468 287709 25455 302890 291759 450222 25425 360445 25308 289318 361422 25151 64527 314843 690263 306332 298066 29292 315916 89824 362431 363522 313837 300857 25046 50654 29521 25741 25505 378947 170923 246272 83799 83781 246250 363463 292804 113940 25060 366988 24189 363875 29757 24191 170667 24642 25518 24206 24699 25374 289032 81687 282817 29192 29489 289820 315949 64189 65192 83841 301005 24479 289231 58857 114091 362329 54243 24248 363247 501072 29448 29214 79209 299825 50866 314787 94197 294329 315272 24648 25019 63880 360854 24472 296456 79129 66021 287427 315348 81679 308666 114023 246280 295347 288779 58945 367562 64035 81675 24434 362029 289211 79113 361378 310864 83782 296654 64630 690945 25423 296321 299121 29565 25095 290029 361929 25407 499271 311396 292072 306600 60350 156767 84497 25531 363494 361697 25227 84379 364867 29662 315222 252902 307039 84431 246324 116590 81736 367915 299331 24464 78963 50645 252929 24426 301252 25551 679787 170538 29511 140868 432363 299732 25290 362432 64537 24257 81613 29142 171341 24856 304966 94167 292666 293154 294673 316033 81506 292073 307833 94195 171361 24375 50692 100360623 296554 59313 116547 24440 690130 65197 24691 287772 29543 171337 29669 499285 140914 24944 79239 116967 25581 29153 54249 81650 309147 303353 299606 29364 365388 683849 291000 85492 25406 29583 287984 103690254 291085 94198 305679 362347 63849 29650 29677 25052 116643 498840 140656 24614 56611 29186 83806 308995 311078 292485 308869 313648 25307 362045 24917 363024 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 97%10230370 Reversible hydration of carbon dioxide 54231 29242 499566 310218 291819 54233 302669 54232 298657 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%10230088 Smooth Muscle Contraction 171115 360820 288057 25118 24851 305679 24244 500450 289759 50685 304816 25202 24852 25687 25206 29431 66012 29432 24584 296313 282843 501203 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 97%10231088 Cargo concentration in the ER 24827 65134 690252 58842 361705 100912115 295461 252929 29183 301012 289994 246117 683007 302470 25423 116666 290994 50592 65165 58817 300743 685144 171049 84599 64154 24648 287275 287276 25407 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%10229956 ROS and RNS production in phagocytes 362802 368044 24599 24598 296981 24600 298451 299971 316519 170667 436582 297566 312488 117596 94170 116664 366545 297932 298103 287610 79129 66021 29757 289407 SUMOYLATION%REACTOME DATABASE ID RELEASE 97%10230720 SUMOylation 83614 690244 58851 315133 310375 313128 83826 501145 297561 304157 25573 308755 297522 291171 301442 499417 690043 290744 25154 296099 24413 25498 117282 308669 60349 362827 313304 63996 116698 300772 24873 83422 60373 81812 114592 64520 64041 500545 300320 25672 84385 24874 25737 64550 361100 299957 367846 313961 60351 691688 363269 361645 293528 102551929 303310 293967 25591 316164 297893 117287 287662 29382 25747 309452 294429 309295 24208 287830 291874 362281 113975 308384 103689978 78973 292085 304132 690251 295692 117021 362335 363287 366016 58958 362557 65274 113929 245922 81738 307151 683983 313038 53372 309626 25497 499974 310258 303730 501403 688041 497672 25493 24890 64627 24705 25094 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-RNO-5655862.1 Translesion synthesis by POLK 309812 171525 288003 116468 25737 288414 100912032 50522 64156 316344 89809 59102 192255 313702 MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 97%10228626 MAPK family signaling cascades 25267 24629 24605 289257 293621 305614 64159 89807 24586 314251 81504 24525 25614 25150 313845 308458 363272 309168 84482 65179 25266 288924 59322 29542 498576 64363 25443 29348 170579 170633 29302 309179 60352 299147 312754 29183 314612 170851 29622 295347 64022 24553 24446 25400 25344 687346 309548 56011 83805 65142 64511 25433 25313 302808 361171 25514 25318 64156 170818 364686 24888 309399 309153 24703 299617 361601 64030 315648 170668 24514 364052 305203 171109 63995 114856 297682 64551 24329 360635 58960 58840 310806 192213 312664 293847 361679 246781 289080 310533 50522 50689 25454 170577 363193 24673 25453 192255 25523 24672 300980 117281 66023 116590 100912032 24498 25467 24412 25525 116663 85252 60587 24592 360814 25597 314596 192126 25326 29372 304893 29376 59325 64053 171081 362572 117284 100909827 24245 24246 294515 293508 29495 60427 171140 25622 25746 25513 305539 85243 296072 24244 116630 24716 85385 25704 100361294 54237 25136 83613 116562 170911 25252 58948 114513 316213 25387 314850 24669 81511 29431 29432 25388 363875 84489 83504 309175 66017 25444 24366 24367 29349 54250 685269 25317 29434 287772 292766 29369 25022 171337 29368 170700 116499 29669 29668 60662 60464 170583 29425 289625 100360846 25114 170582 117263 313838 25581 29666 315707 79114 303353 365388 29496 498596 432361 117262 24410 85492 24827 84009 287984 25676 65138 114486 94198 305679 29673 29433 29671 29670 29677 29676 29675 25193 25594 81827 24408 64465 24628 83806 311078 301555 362045 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%10228322 Tyrosine catabolism 681913 29383 24813 29531 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%10228484 Transport of Mature mRNA derived from an Intron-Containing Transcript 689116 687575 298075 362098 259170 297522 494445 89827 79227 29667 59087 501621 362687 290519 287113 689890 298385 360726 361814 294429 287830 291874 362281 113975 292085 295692 360972 117021 362335 315170 288701 295284 366016 313308 58958 362557 65274 113929 296219 114612 362819 245922 81738 313449 683983 53372 690303 305714 25497 361990 499974 690585 361859 303057 688288 361542 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) 140583 299112 316235 171525 298098 85482 288003 289777 287634 362385 116468 192218 290805 25737 293489 304573 288414 50522 305000 308755 306734 300711 302982 192255 59294 360588 497856 302953 64012 499870 293678 100912032 497672 498265 293452 64557 64156 289758 102551085 303194 291787 498119 89809 499966 59102 689055 64046 361698 INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling 24918 25125 25326 25126 365769 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-RNO-1299361.1 TWIK-related alkaline pH activated K+ channel (TALK) 688996 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-RNO-1855167.1 Synthesis of pyrophosphates in the cytosol 688862 500709 94267 294292 306808 50560 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-RNO-9033241.1 Peroxisomal protein import 685325 266686 311446 303272 641452 25700 24792 64156 363445 116718 64460 297570 65030 29725 305581 50522 29534 308518 308718 25541 291075 114027 503049 192255 117265 311849 85255 79244 50559 291922 297029 293067 65192 24599 64526 360463 50681 84114 312703 84470 365571 24479 114209 113956 100912032 79238 81920 85239 84029 680424 64461 361831 24248 314304 83842 83522 501072 361413 171142 RELAXIN RECEPTORS%REACTOME%R-RNO-444821.1 Relaxin receptors 295144 114215 266997 294807 25616 SIGNALING BY PDGF%REACTOME%R-RNO-186797.1 Signaling by PDGF 25267 24629 25692 24605 445442 300955 293621 170911 306628 25676 25125 25126 81504 287942 24525 313845 25738 290905 292406 79429 66018 316369 84427 25266 24628 25414 117255 25622 25513 85243 83805 85253 54281 54245 24918 25353 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-RNO-9818564.1 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 302783 290939 299905 679693 24708 24829 306945 24828 84578 117056 85265 680498 83724 685909 680615 497991 25664 619436 365877 83516 291567 311860 300367 293500 365755 302711 303175 306030 309757 140908 64627 299607 287475 303403 497941 690795 299180 317343 316209 SIGNALING BY ALK%REACTOME%R-RNO-201556.1 Signaling by ALK 100910984 170911 25513 25125 297893 84578 85243 25467 25613 25738 85385 679566 24924 116689 25326 81517 266802 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%10229244 GAB1 signalosome 64019 24329 24827 59325 360820 25622 170911 361388 25513 81504 83805 25433 64022 25313 29183 315707 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-RNO-166058.1 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 680127 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 97%10228564 Beta oxidation of myristoyl-CoA to lauroyl-CoA 25287 171155 170670 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-RNO-5656169.1 Termination of translesion DNA synthesis 299112 316235 171525 298098 288003 362385 116468 298693 25737 304573 288414 50522 300795 307905 192255 100147704 59294 295704 100912032 289758 64156 316344 89809 59102 361698 DISINHIBITION OF SNARE FORMATION%REACTOME%R-RNO-114516.1 Disinhibition of SNARE formation 114095 25023 24681 24680 81803 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 97%10229180 APC C:Cdc20 mediated degradation of mitotic proteins 25203 117262 64193 85492 54237 287984 65138 94198 366381 29673 50522 292588 293155 29671 296368 29670 361389 288671 29677 290875 29676 29675 305420 360643 192255 81827 64515 83806 297176 295052 311078 287772 292766 100912032 29669 29668 114494 29425 64156 100360846 361831 117263 25581 29666 303353 365388 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-RNO-6807047.1 Cholesterol biosynthesis via desmosterol (Bloch pathway) 117278 114100 293688 64191 25427 140910 298298 29540 309262 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins 307838 286976 29750 313878 362760 362924 304571 65196 685758 170501 25197 309114 100360475 303692 288611 120100673 100361647 116740 690914 290638 311952 29758 311039 302499 65044 292325 102550196 366061 313233 83627 308440 316583 305571 79214 362275 361142 499968 363040 497227 64442 291958 64445 64043 367384 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%10230130 Interleukin-2 family signaling 65038 116558 116562 170911 25155 50646 25125 25126 81504 365769 84477 313845 366508 25670 171081 25746 25513 85243 116630 313050 690369 60664 85385 25704 24918 116689 25326 24514 54259 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-RNO-427359.1 SIRT1 negatively regulates rRNA expression 302783 24829 302553 306945 303175 24828 309757 64627 117056 690795 680498 685909 680615 308911 365877 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%10229614 Catecholamine biosynthesis 25699 24311 25085 24661 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway 50689 58960 24703 170851 116590 114486 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 97%10228750 Activation of caspases through apoptosome-mediated cleavage 64026 78963 58918 25402 63879 25309 690675 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 97%10228416 Caspase activation via extrinsic apoptotic signalling pathway 25311 60350 29260 58918 64044 364867 448830 266610 25402 306886 246097 117279 25385 246756 363328 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 97%10231188 ERBB2 Activates PTK6 Signaling 29496 25433 64022 498596 25313 432361 366275 24329 59325 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-RNO-75953.1 RNA Polymerase II Transcription Initiation 170844 83830 171152 309638 289561 292778 288651 288533 373541 293345 294018 361580 303918 117526 294693 83503 117017 291703 498109 363633 287571 288588 266713 291773 316123 317256 502227 83828 690966 361365 81673 84389 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 97%10228686 Signaling by GPCR 24605 25666 293621 287730 497978 24816 24938 81504 24525 25107 499913 25229 688605 689936 316019 313845 29385 246075 379044 282832 25340 554302 50672 25342 29141 60590 292409 58959 64042 309207 53949 308408 25477 294394 246759 58965 29397 24260 58966 25593 25111 292419 29151 24476 25323 81509 59264 63887 292661 25324 63889 25569 297795 25447 767613 25689 25329 25449 81753 29363 54258 500157 84348 25321 24232 81752 24473 305236 50577 289023 171551 65032 24925 24806 24808 24929 290493 292794 117549 24247 316259 295144 316137 192223 317219 25570 81503 24241 29256 498289 362505 100360071 497196 100911796 497078 25542 24695 64636 302619 81648 299242 117264 57305 81657 353250 308163 84007 24694 117027 57302 89810 100270683 360579 29581 171056 365228 306307 25555 29238 89808 81644 689869 29595 29237 192205 29235 365901 192206 170634 29597 29234 84475 29471 171044 24318 102552838 360918 294123 116700 314386 171519 24797 294124 685243 24677 25524 25645 294121 25083 114098 114099 29446 81672 25087 84023 399475 294807 294075 25653 25652 24323 24326 81779 24448 81668 29335 301086 690158 367315 24418 24659 266997 24417 59301 117273 83805 24419 24772 114105 24414 60628 24416 25504 24415 445269 309212 25187 83633 78964 500091 171371 494319 497942 56813 117064 64680 498475 192648 192649 246358 29316 114215 338443 297025 25635 116637 25637 25516 408199 25194 29310 56820 310444 25075 25195 29555 316009 192646 310327 501177 500089 100310876 301066 25726 25605 113914 679957 140928 287910 298006 63885 116506 25723 24875 29407 81743 25040 78981 78980 25262 171158 78983 362454 78985 498335 117041 25616 366270 24769 366274 29538 117029 245920 83518 24889 246219 266607 60669 25051 60665 29413 29412 78976 25298 679975 54305 85268 78979 302378 25706 25026 170926 24179 259224 259222 25029 24613 25380 25264 24174 690448 24175 25024 60432 25265 361383 363682 29180 288995 378939 498791 691774 116677 319107 64803 319105 24182 25033 29191 287673 499194 113959 24717 25245 25369 63843 25513 25248 170704 117518 24953 25007 260319 60337 680188 25360 58812 287561 287562 24604 60664 85385 63850 502757 171104 171108 500101 83567 24166 310869 29290 171101 58949 170911 25740 362477 308118 25387 25679 81678 295378 60395 29431 25388 29636 116498 29516 24511 298947 84009 497931 497932 24807 304109 64465 114559 25537 29491 81645 59075 50678 308776 309962 25108 25233 367901 25433 24221 315648 81771 117269 24329 50689 363193 24673 363143 29481 501560 24672 117281 116590 29414 54226 81745 24185 64199 24654 286924 83506 24611 79218 24180 360616 24627 24626 25638 81636 245986 25238 24668 60449 25031 293508 302950 25372 85240 294962 64532 25521 25686 25289 25643 25601 25725 83579 29241 680149 84420 58979 140908 64373 24244 170538 114117 24400 64508 81742 25050 81666 81667 24681 29699 24680 29340 81662 81664 306618 66013 60341 29691 500608 317598 298404 287537 287418 310460 307098 120099896 246174 311647 363509 310635 310999 78966 140898 54296 361921 307398 309653 117020 303634 301334 295449 363460 310192 114513 293024 100362710 687105 362648 25320 54248 81749 688705 29254 406163 305795 29480 54289 54294 54293 54292 54297 81663 498246 301088 84583 100361166 59293 84022 114705 246254 362021 289076 81821 140866 100361138 66025 306792 298062 60399 310812 116744 29415 29733 500317 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%10231266 Regulation of RUNX3 expression and activity 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 59086 29676 29675 192255 81827 83806 311078 156726 287772 292766 100912032 83805 690516 29669 29668 361391 29425 64156 100360846 117263 25581 29666 303353 365388 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%10230932 Cargo trafficking to the periciliary membrane 117103 171044 309451 64632 363272 60627 25273 114089 100910342 171455 116654 113948 24818 50556 365770 288305 245709 79120 294864 500832 316102 295230 25411 29374 314961 299246 85258 311456 24650 362142 24717 363760 679894 299809 361930 81830 29885 252881 363126 305287 361789 64664 83567 367714 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-RNO-110314.1 Recognition of DNA damage by PCNA-containing replication complex 313387 59294 299112 298098 288003 81816 362412 362385 116468 25737 304573 288414 100912032 50522 289758 64156 363164 361181 89809 59102 192255 302502 361698 PDE3B SIGNALLING%REACTOME%R-RNO-165160.1 PDE3B signalling 29516 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181429.1 Serotonin Neurotransmitter Release Cycle 25531 84556 29130 64830 64832 25549 29179 25012 140592 25716 24949 293645 25558 116470 24803 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-RNO-2395516.1 Electron transport from NADPH to Ferredoxin 79122 29189 313786 SYNDECAN INTERACTIONS%REACTOME%R-RNO-3000170.1 Syndecan interactions 25724 25216 170921 296456 25615 24511 59086 54250 24680 116673 24771 29302 B CELL ACTIVATION%REACTOME%R-RNO-983705.1 B Cell Activation 100361818 361400 24605 24674 293621 24675 25679 367901 81678 81504 24525 100360919 313845 29337 307366 287772 25513 29434 292766 81515 29669 24244 29668 29425 64156 100360846 84357 117263 25581 29666 116689 303353 309295 365388 89821 117262 85492 25023 300955 25155 287984 65138 94198 29673 50522 29671 84351 29670 366508 29677 29676 29675 192255 362046 316241 81827 294048 308501 287280 25639 83806 311078 25262 361765 100913063 499356 305584 100912032 81736 25493 309361 303024 361618 29748 83477 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%10231546 Cellular response to starvation 500843 297522 100362347 502988 297932 360497 362573 298103 362441 690751 360969 303185 305464 363138 289407 304410 362802 368044 298451 299971 308869 170667 310091 436582 298514 64226 295357 297566 312488 117596 297960 94170 26954 116664 117044 366545 117043 362045 56718 360776 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-RNO-212165.1 Epigenetic regulation of gene expression 316328 314704 290939 299905 679693 108348224 84578 301164 296653 311860 365755 302711 102546572 100909569 368002 140908 691153 24522 308911 365192 306817 116698 301246 361784 360893 361420 689883 120095871 680155 366975 313245 680493 362728 83582 317399 690450 83581 102556967 690966 65261 117526 83503 29417 498109 85265 83724 361487 302553 290270 309757 681740 83712 60571 315606 290829 444984 690559 246264 302783 303539 100362170 24708 24829 306945 24828 306274 362093 313048 117056 680498 685909 680615 287876 497991 25664 619436 365877 83516 310958 289881 100359816 291567 300367 293500 498112 300206 84027 291440 100362634 303175 102550344 300266 313323 688041 207118 306030 311575 314964 299569 360581 299607 64627 287475 497941 303403 690795 299180 311468 304794 26295 362414 293488 317343 310194 84486 316209 360642 362224 309001 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-RNO-9839397.1 TGFBR3 regulates FGF2 signaling 54250 83823 29610 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-RNO-418038.1 Nucleotide-like (purinergic) receptors 100911796 29290 29597 302378 29316 117264 25369 63843 310444 25265 317219 767613 171108 691774 64803 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%10228406 Resolution of AP sites via the single-nucleotide replacement pathway 84495 79116 29240 SOS-MEDIATED SIGNALLING%REACTOME%R-RNO-112412.1 SOS-mediated signalling 25467 313845 29376 81504 GLYCOLYSIS%REACTOME%R-RNO-70171.1 Glycolysis 25741 24651 24334 316265 315722 292804 25060 297522 292138 24189 296973 289608 54283 25438 685076 24385 66020 100364027 24638 24959 60416 498731 24191 24849 25059 24640 24642 24644 25658 117276 65152 294429 287830 291874 362281 113975 292085 295692 117021 362335 366016 58958 362557 65274 113929 245922 81738 683983 53372 25497 499974 BASE EXCISION REPAIR%REACTOME%R-RNO-73884.1 Base Excision Repair 302783 84495 299112 298098 288003 362385 116468 24829 306945 25737 24828 304573 288414 685909 680615 290232 297758 365877 500054 307798 362600 307861 290027 59294 84490 25591 79116 29240 83507 303175 170841 680915 367090 315344 81528 305957 64627 690795 289758 89809 59102 361698 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes 316328 363026 306571 60421 363292 84578 313539 301128 102554884 315210 365755 302711 303470 303514 298595 296501 29520 317464 54282 29512 29511 297597 310352 688634 299305 290284 100362346 310614 361724 689883 290669 362834 64520 83789 294924 83724 100366024 365155 362831 689954 679713 306764 310638 308345 361688 290831 498295 291844 299295 289372 364785 302553 500569 689820 297893 94201 81647 83712 288563 315606 361402 298144 309452 290925 303518 64646 295384 290829 297867 444984 58919 363481 502125 296732 89820 83833 362981 301020 24829 361925 306945 361825 24828 317432 362093 313048 317425 312440 684297 689582 304809 682469 266670 304495 680498 363630 103689969 360665 680615 310769 365877 100359816 300206 100362634 303175 102550344 688041 311575 81736 117535 64627 362825 497941 360531 304794 84481 26295 293668 83618 314205 310194 360642 309001 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%10228160 Lagging Strand Synthesis 59294 84490 288003 289758 116468 301323 25737 89809 59102 288414 85241 361698 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%10231116 rRNA processing 291317 291434 81729 25347 29304 25348 28298 313707 305258 65136 360828 27139 64205 26962 64462 289809 313167 294282 310720 300092 100910714 363134 362967 681429 117053 100362640 64298 161477 289810 290641 296865 192180 359727 303608 94266 362214 360552 305076 314617 310019 315705 140654 85432 140655 60373 366017 361923 134480579 102551819 117042 287120 287122 291987 499782 294975 103689992 297685 291061 140661 29258 140662 29257 362902 362229 300079 291996 292964 293418 317399 290660 291071 81768 100361974 81775 81776 314713 362631 679140 313744 360574 360572 81773 81774 361262 245981 497860 81770 300045 308201 290556 691531 64640 83789 361159 81764 686999 81765 81766 122799 114021 81767 29236 81763 312706 300050 690297 100361060 309301 58927 293828 292747 689284 288647 100361756 100360664 368084 29288 29287 29286 29285 316317 124323 307850 29284 29283 29282 296709 289740 64302 64306 314830 100360439 64307 58822 64156 298065 314545 122772 361452 134486107 362703 361977 363237 362426 50522 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%10228162 DNA strand elongation 59294 84490 288003 116468 25737 288414 85241 289758 301323 89809 292058 59102 307639 499914 290842 361698 HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state 287612 59320 65209 304729 307724 308577 100362124 305349 303968 295654 289180 116475 361769 89830 81636 312651 503018 362265 140588 140589 293508 302950 64532 25521 25289 25725 287772 29241 292766 84420 29669 29668 29425 64508 64156 100360846 117263 25581 29666 29699 303353 365388 117262 85492 287984 65138 311567 94198 29673 50522 29671 29670 29677 29676 25273 29675 113927 192255 81827 287280 83806 311078 84027 361765 100912032 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%10230728 Initiation of Nuclear Envelope (NE) Reformation 24672 25203 54237 117104 25437 117281 114087 24917 116685 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME%R-RNO-9940951.1 Interaction of NuRD complexes with transcription factors 302783 24829 306945 303511 24828 307362 305501 293038 313048 291940 113984 117056 406195 680498 360804 685909 680615 365877 100362346 310614 303175 361724 297893 290669 362834 64520 117535 64627 690795 100359714 83712 50659 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade 680127 64156 25742 81647 116725 314322 311245 315648 309452 309295 81771 310877 117269 500133 363520 291921 64044 300447 313121 362491 287707 363855 25272 50522 50689 84351 24516 289014 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 25493 312688 116663 54226 309361 60587 303024 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle 83589 25531 84556 29130 64830 29647 64832 25549 60377 29179 25012 140592 25716 24949 293645 25558 116470 24803 60442 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%10229754 Semaphorin interactions 314641 311384 24699 316639 78966 361597 29433 310207 309280 25150 313498 315711 29431 316009 29432 363875 301252 246331 289392 361537 306400 25537 65208 84027 310630 117273 362993 306790 140908 29751 64373 296789 361568 25418 24553 25415 312213 25417 299331 25416 363517 116671 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 97%10230438 Collagen degradation 291848 499431 300338 81707 25335 103690254 100169747 81687 25697 685612 300341 29175 117061 117033 362347 81686 63849 315388 54281 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%10229626 Platelet sensitization by LDL 24672 25622 79113 117281 29583 362558 309179 299147 363193 312754 24673 54225 315648 116689 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%10229280 EGFR downregulation 24329 24827 59325 81922 313474 81504 50522 498798 29183 500985 192255 56084 294981 81921 306141 64465 114559 116743 117255 311030 361120 100912032 25433 64022 25313 64156 84357 117277 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%10230222 Regulation of signaling by CBL 170911 25155 25513 81515 85243 287942 81504 25150 25734 366508 60664 500985 54245 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-RNO-166166.1 MyD88-independent TLR4 cascade 641452 246240 266610 306886 60371 299827 25622 287545 252961 362788 292892 64156 25742 81647 116725 314322 311245 315648 363328 309452 309295 81771 310877 117269 500133 60350 363520 29260 293624 291921 64044 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 246294 363193 24673 315599 500900 315994 192255 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 81920 448830 25493 312688 116663 54226 309361 60587 361831 303024 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9033807.1 ABO blood group biosynthesis 81919 58924 100301568 DEATH RECEPTOR SIGNALING%REACTOME%R-RNO-73887.1 Death Receptor Signaling 688466 81859 687813 498803 83427 115771 114210 312937 364386 63879 29753 313845 25402 299827 360827 301059 94193 306618 66013 500608 317598 298404 287537 287418 310460 64639 307098 120099896 246174 311647 363509 310635 246244 310999 78966 140898 361921 307398 309653 117020 303634 301334 295449 363460 310192 64547 114513 293024 100362710 687105 362648 81920 361831 641452 295378 266610 306886 363875 60371 363836 287155 117273 100362554 64156 310738 311401 308493 311245 362828 309295 363520 84009 64044 300802 25625 313121 362491 64314 83537 57027 50522 84006 24596 84351 29409 29192 94338 289014 246294 117089 360678 83765 292788 450224 362548 246097 117279 25385 246756 192255 81751 304109 116554 114559 308267 289231 29491 113894 100912032 317546 81736 60383 25493 309361 24835 290864 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-RNO-168898.1 Toll-like Receptor Cascades 362862 299827 25622 292892 295214 171574 310553 501570 246280 81920 25751 361831 54225 305354 50654 94195 25697 29175 641452 246240 29337 266610 363131 306886 116547 60371 65052 291359 296321 24366 680127 24367 287545 246116 252961 353316 362788 64156 25742 63865 81647 116725 684440 314322 361689 311245 317468 305355 315648 363328 309452 309295 81771 140694 310877 117269 500133 60350 363520 29260 293624 291921 64044 300447 313121 362491 287707 363855 364867 25272 50522 50689 84351 24516 289014 246294 363193 305549 116667 24673 315599 500900 315994 192255 309157 315305 114495 501560 116596 24672 116554 287280 362418 300980 308267 117281 361765 50658 116590 291861 100912032 317546 81736 448830 25493 312688 116663 54226 309361 60587 303024 312562 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-622327.1 Postsynaptic nicotinic acetylcholine receptors 25590 29422 25103 81721 54239 25753 170945 54240 171131 65024 25302 79557 SIGNALING BY SCF-KIT%REACTOME%R-RNO-1433557.1 Signaling by SCF-KIT 140583 24605 293621 170911 25125 25126 81687 81504 361597 24525 25150 84477 313845 114203 500985 366962 363875 84427 363616 25627 301737 60427 84492 25622 498416 25513 81515 83805 313050 60664 24918 64030 24680 116689 24514 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 294962 25686 25643 83579 680149 58979 64199 286924 114117 24400 79218 81667 245986 60449 81664 64803 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-RNO-2022377.1 Metabolism of Angiotensinogen to Angiotensins 25627 266704 290257 54242 24715 113936 24310 64017 24179 24590 113902 302526 252929 302668 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-RNO-5654696.1 Downstream signaling of activated FGFR2 24605 25443 293621 170911 29348 361388 170579 170633 81504 24525 313845 25738 66017 25444 25622 29349 54250 25513 25317 29369 25022 316213 29368 314850 170700 116499 60662 60464 170583 85385 INTERLEUKIN-7 SIGNALING%REACTOME%R-RNO-1266695.1 Interleukin-7 signaling 25467 29376 680498 60664 688621 24918 25513 25125 25326 25126 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%10230724 Nuclear Pore Complex (NPC) Disassembly 287830 291874 362281 25203 113975 54237 292085 295692 117021 362335 366016 58958 362557 65274 113929 297522 245922 81738 683983 53372 25497 294429 499974 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%10230960 RHO GTPases regulate CFTR trafficking 85428 24255 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 97%10230076 Miscellaneous transport and binding events 304203 289594 305135 287478 25230 65207 290783 293048 310625 289443 64673 79032 116967 114506 303070 24171 361069 362642 305131 311846 308668 24170 308667 FREE FATTY ACID RECEPTORS%REACTOME%R-RNO-444209.1 Free fatty acid receptors 292794 365228 266607 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-RNO-5218921.1 VEGFR2 mediated cell proliferation 170897 24605 25023 293621 25522 25589 25676 81745 83805 24525 170538 25738 83785 24680 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation 66017 25444 29349 84489 25317 29369 29368 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-RNO-5686938.1 Regulation of TLR by endogenous ligand 310553 60350 29260 24366 24367 94195 353316 295214 448830 54225 116547 317468 305354 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%10228860 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 366381 292588 293155 296368 64515 361389 288671 297176 290875 361831 305420 360643 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-RNO-380972.1 Energy dependent regulation of mTOR by LKB1-AMPK 25520 83803 303605 290291 64562 308869 310091 298514 24855 501146 64226 373545 295357 314621 297960 60445 65248 26954 117044 117043 362045 56718 360776 24666 GLYCOPROTEIN HORMONES%REACTOME%R-RNO-209822.1 Glycoprotein hormones 29200 64549 25196 25447 83711 25329 116700 24504 25653 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 97%10229700 trans-Golgi Network Vesicle Budding 310746 363476 306332 29292 192243 304344 252929 366618 299825 312689 56084 64630 85491 81803 365191 171575 361459 309451 294900 288785 116561 364183 289312 295217 64310 64678 116743 317630 100362805 25306 89816 83730 83576 140673 25387 313409 192152 25319 362609 689256 25751 296199 54226 312694 81659 24468 287709 361632 83800 366311 641528 295171 54241 25151 683687 24803 KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization 287699 689230 406227 299587 287698 295190 406226 309528 406228 361319 307563 25626 683313 680060 307562 120093742 306871 680703 407762 134478810 315320 102551497 304822 315324 407760 315323 680152 315318 100363184 685544 360626 360623 287675 303523 303528 287679 303527 680071 300242 300247 300248 303519 100909661 680454 300250 286912 102553726 450230 100364550 294853 450228 134481131 291755 450227 690478 450229 100359886 497995 369017 81679 450225 100361571 407757 407758 266717 120095335 287701 287700 287702 291754 102546758 302934 24332 313672 310575 294094 680104 60335 499345 292848 308564 291759 292949 682408 293619 408235 287925 287697 291760 HEME SIGNALING%REACTOME%R-RNO-9707616.1 Heme signaling 448830 25081 303333 304127 24440 360504 29260 85252 361940 54225 500336 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%10231624 Regulation of CDH1 Expression and Function 314641 83427 50654 83502 25697 25150 266758 292064 293142 84430 688673 25705 81717 500569 287772 689820 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 25507 29425 64156 100360846 54281 83712 117263 25581 29666 81650 303353 365388 302783 117262 85492 192275 313474 24829 306945 287984 24828 65138 313048 94198 29673 50522 305679 100188932 29671 29670 117056 29677 680498 29676 29675 84353 685909 680615 192255 365877 686092 81679 81827 116549 311163 83806 311078 313648 303175 688041 100912032 300445 29144 64701 29606 64627 25751 500870 78947 690795 293721 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 97%10231614 Regulation of Homotypic Cell-Cell Adhesion 314641 83427 50654 83502 25697 25150 266758 292064 293142 84430 688673 25705 81717 500569 287772 689820 292766 297893 290270 85489 83805 309757 29669 29382 29668 362040 25507 29425 64156 100360846 54281 24790 83712 117263 25581 29666 81650 362850 303353 365388 302783 117262 85492 192275 313474 24829 306945 287984 24828 65138 313048 94198 29673 50522 305679 100188932 29671 29670 117056 29677 680498 29676 29675 84353 685909 680615 192255 365877 686092 81679 81827 116549 311163 83806 311078 313648 303175 688041 300289 100912032 84407 300445 303068 29144 64701 29606 64627 25751 500870 78947 690795 293721 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME%R-RNO-112307.1 Transmission across Electrical Synapses 266706 362979 315435 50564 TRANSPORT OF SMALL MOLECULES%REACTOME%R-RNO-382551.1 Transport of small molecules 79213 29579 299488 363120 293485 288707 313771 681896 500132 85254 50719 64201 170551 294255 315439 303333 309111 24941 170943 64831 291470 295669 305886 117152 65039 94106 64018 296578 291582 25239 25176 116642 25400 680602 311839 498910 170496 25344 266998 65202 114511 29735 312382 24565 295417 65142 24703 29726 291733 317170 498185 305846 295455 311651 58976 170840 171135 192215 314637 316519 117240 361986 363985 56814 25715 306009 294698 314396 24784 24783 29715 311387 362861 294281 24782 84550 299903 140447 300051 85267 140448 289353 363115 363103 24898 170567 116509 266767 171148 83511 84487 116638 64198 301418 688685 287979 295462 307350 171433 353231 365567 29483 364601 293048 310625 29642 29482 24245 24246 25506 85426 171140 79212 114507 171147 252854 366432 360539 309131 362403 54302 54301 25553 310732 25550 171163 83612 84012 64310 64678 25319 83800 54241 29292 116601 25391 29693 29600 29599 29598 60395 289443 64673 297932 79032 114506 303070 298103 24171 361069 58978 114628 140860 362642 305131 302973 24255 311846 29757 116721 289407 308668 170924 308667 304203 25303 24891 362802 289594 305135 54318 85493 368044 286970 296981 298451 303639 299971 287788 83615 79248 81642 170667 302395 436582 299609 297566 296302 312488 63886 314537 117596 94170 83535 116664 25560 366545 25081 304805 171015 300664 365345 362302 299027 301482 155192 140668 140669 65200 80878 25027 116726 83509 25650 84551 307811 25390 24825 303796 170698 24186 170520 65046 25749 293735 304315 292168 286920 689103 297930 63866 294141 314401 312981 312896 83514 295041 497948 361586 192675 58950 29465 299714 171497 364973 679906 499287 66026 362053 85256 59299 689991 29233 29232 79123 362247 314847 308015 294329 293874 315272 63882 266730 116469 114246 83470 25688 689560 79430 83810 25122 25364 140933 301111 292597 246215 311287 24768 24767 79425 89821 308637 171143 367318 171384 170824 287532 113918 314441 311168 29464 170566 29485 29484 282712 252919 155205 192208 664630 246235 298340 170573 305540 59108 85382 83500 365398 89776 116563 29509 85333 246280 81830 54225 266612 25108 29502 315311 81826 503568 246234 84484 295645 58980 297386 24780 24781 64672 24211 24212 24213 63847 63848 58971 64190 116831 50655 29639 29132 24170 300438 287478 246239 117261 140670 313139 296969 311204 24904 306866 310808 29504 29503 50662 64156 499991 24221 29199 288562 288026 361929 287276 291411 291555 311396 24217 365266 303056 306600 171496 360932 303856 290673 362645 50522 192255 287280 100912032 58851 298203 114766 64199 79218 245986 60449 25480 293508 25241 25490 25386 65054 65133 294962 286758 25521 25293 25132 367316 303205 29172 29171 64522 25725 25551 304785 313210 83579 501925 295245 680149 25139 58979 294341 24778 65194 24244 24539 114117 25507 24400 25649 291437 25728 100361444 81667 292697 24530 29699 116548 315218 362850 502970 140915 310900 25080 84511 259248 140638 432363 83519 25270 363516 691209 29501 54300 308069 84356 83629 171373 289459 25548 84395 353307 60423 63997 140944 117955 300027 25240 54231 29242 310218 24440 360504 25230 65207 24779 25552 289874 287772 292766 290783 29669 29668 24451 79239 29425 100360846 116967 54281 117263 25581 29666 303353 365388 290823 117262 114629 85492 25246 29440 407784 360670 117267 297910 304784 24153 287984 301010 65138 94198 29673 29671 29670 29677 29676 29675 116643 64037 81827 29743 362188 117100 83806 311078 50676 362891 114613 266732 314459 50567 298296 306825 690315 294930 360967 80848 25073 25292 680551 81782 266770 363024 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%10230448 Assembly of collagen fibrils and other multimeric structures 678743 84032 50654 25335 306628 81687 300341 25697 290905 301012 85490 24914 29569 554172 60379 25681 304021 83470 365460 290350 309380 294279 25412 25654 315714 DNA DAMAGE REVERSAL%REACTOME%R-RNO-73942.1 DNA Damage Reversal 303193 291905 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-RNO-416550.1 Sema4D mediated inhibition of cell attachment and migration 306400 316009 361568 24553 363875 117273 306790 362993 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%10230112 Other interleukin signaling 25613 25216 25012 682457 25402 24932 498951 81802 81803 116470 24803 81804 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-390648.1 Muscarinic acetylcholine receptors 25229 53949 81645 24260 25111 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%10229220 Processive synthesis on the C-strand of the telomere 307798 307861 59294 84490 290805 25737 308755 289758 290232 59102 297758 361698 500054 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-RNO-5654693.1 FRS-mediated FGFR1 signaling 83504 24605 66017 293621 25444 25443 25622 29349 54250 25317 170579 170633 316213 81504 314850 29368 24525 170700 116499 60662 313845 170583 79114 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 97%10230344 Metal sequestration by antimicrobial proteins 116547 94195 170496 301034 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-RNO-381033.1 ATF6 (ATF6-alpha) activates chaperones 304962 89842 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME%R-RNO-5654221.1 Phospholipase C-mediated cascade; FGFR2 66017 25444 25443 29349 29348 54250 25317 170579 29369 170633 25022 29368 170700 116499 60662 60464 170583 25738 PRE-MRNA SPLICING%REACTOME%R-RNO-72163.1 pre-mRNA splicing 294232 689116 298075 368070 117259 295334 497967 501285 361449 259170 302969 494445 29578 81781 294783 29667 298342 79256 292019 292810 64200 83624 362687 310687 319110 287113 100910202 291295 314336 500790 117280 117282 246216 689890 500538 298385 361814 303346 287530 366163 287415 362361 297695 245976 309651 313588 84401 295284 680891 311855 367930 245957 302557 290284 313450 302855 362260 313449 690303 362152 362394 686980 80846 313583 314313 679890 170933 361859 290614 288588 24468 296320 316123 690966 361365 289561 292778 83503 117017 498109 363633 305884 291794 687711 288701 313433 362153 300361 363005 292535 294711 100362099 293862 114612 681031 100361269 312474 288718 500242 192246 308650 303607 363151 171365 85434 680737 60376 305479 140931 690585 307410 171552 301432 361887 303057 498171 688288 287768 29497 299620 295270 498600 289315 64510 89819 84486 300687 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-RNO-420092.1 Glucagon-type ligand receptors 117064 294962 25321 81779 24875 25040 83579 680149 24953 58979 64199 24769 114117 24400 25024 60432 79218 29555 81667 29446 245986 25051 60449 24166 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%10230046 Lysosome Vesicle Biogenesis 310746 306332 365191 171575 304344 361459 252929 366618 299825 312689 56084 288785 116561 64310 116743 85491 100362805 83730 25387 313409 25751 54226 24468 83800 366311 54241 24803 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%10228994 PKA-mediated phosphorylation of key metabolic factors 171078 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-RNO-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) 84429 RET SIGNALING%REACTOME DATABASE ID RELEASE 97%10231234 RET signaling 498898 313644 25136 29376 170911 502694 361388 81504 25454 84477 313845 366508 25738 361364 362572 59312 25453 84427 293508 25622 66023 498416 25513 85243 83805 314850 25525 24716 60664 85385 24680 312477 286908 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes 363520 301059 362491 113894 100912032 50522 84006 24596 84351 64156 310738 311245 192255 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 97%10229508 Negative regulation of the PI3K AKT network 294235 50557 25267 24629 29376 59325 24185 25660 81504 25408 25556 25150 84477 25149 308875 60427 25266 25622 301059 25513 85243 60664 116723 25443 170911 29348 361388 170579 300177 170633 309179 299147 366508 312754 29183 24506 24505 140607 314850 64022 24553 24446 314641 89812 25233 29613 363875 246273 84489 361992 83504 66017 25444 29349 54250 25317 29369 25022 83805 29368 170700 116499 25433 60662 25313 365865 313050 60464 170583 81737 289625 25114 25054 170582 25730 24225 311245 64030 315648 79114 29496 498596 432361 363520 24329 24827 298947 64545 497931 497932 50689 363193 24673 294048 24672 24628 309419 117281 116590 25466 25467 24890 56822 29414 29149 361749 59265 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-RNO-6804116.1 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 83571 114494 295052 362485 314818 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%10229762 Recycling pathway of L1 116563 50687 116743 140670 54319 116590 83805 84393 65046 81521 25751 171574 25416 83800 54241 140694 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-RNO-450282.1 MAPK targets Nuclear events mediated by MAP kinases 501560 117269 24672 116554 300980 117281 50658 116590 25272 50689 24516 116663 289014 363193 60587 81647 24673 314322 315648 315305 81771 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-RNO-9603381.1 Activated NTRK3 signals through PI3K 29613 81737 83805 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%10231722 Strand-asynchronous mitochondrial DNA replication 85472 303612 309441 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-RNO-1296072.1 Voltage gated Potassium channels 25736 296395 29738 29737 171146 29731 307900 684516 27150 65195 117018 25468 25469 294065 295360 246153 117023 114032 116695 307234 171011 66022 365241 259273 60326 25470 83588 246325 116745 25327 65180 84020 65198 170739 24520 58981 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 307096 65192 192242 498789 25270 171516 301517 79111 361266 246211 291283 362782 191574 364773 498790 307092 MMR%REACTOME%R-RNO-5358508.1 MMR 305000 59294 81685 289758 81709 25737 59102 361698 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 97%10230698 Sensory perception of taste 170634 78979 29407 78981 78980 25679 78983 78985 286924 690448 680188 100270683 24400 25122 246219 554302 500089 100310876 500091 689869 500101 60449 24768 24767 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D 58919 117262 85492 287984 65138 94198 29673 50522 29671 29670 29677 29676 29675 192255 81827 83806 311078 287772 292766 94201 100912032 29669 29668 29425 64156 100360846 117263 25581 29666 303353 365388