S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 Glul ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a5 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Acat1 Acat2 Gcdh Echs1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5f Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk Bpnt2 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm1 Dut Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Dtymk Nme7 Nme6 Ntpcr Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Ggt5 Gstm4 Alox12 Gpx4 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Ggps1 Acat1 Hmgcr Acat2 Mvd Hmgcs2 Fdps Idi1 Mvk Pmvk L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Gstz1 Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Tomt Aldh2 Aldh3a2 Adh4 Maoa Pnmt Comt Maob N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda1 Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Amdhd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Plcb2 Ip6k2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Inpp5d Pi4kb Itpka Pi4ka Plch2 Inpp5a Plch1 Plcd1 Synj1 Inpp5b Plcd4 Itpkc Plcd3 Itpkb Itpk1 Ipmk Cdipt Pik3cg Pik3cb Ocrl Pik3cd Pip4p2 Pten Pip4p1 Inpp5k Pik3ca Pi4k2b Plcz1 Synj2 Inppl1 Pik3c2b Minpp1 Plce1 Pik3c2a Pik3c2g Fig4 Pip5kl1 Mtmr3 Ppip5k1 Ppip5k2 Pip5k1c Pip5k1b Pip5k1a L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Aldh4a1 Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Pnpla1 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis Carns1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Cad Umps Dhodh GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh Nt5c2 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Cox6a1 Ndufa10 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufa13 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs8 Coxfa4l2 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cyc1 Ndufb2 Uqcrc2 Ndufb3 Uqcrc1 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Cox6b1 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcrb Uqcr10 mt-Co2 mt-Cytb mt-Co3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 Ndufc2 mt-Co1 Sdhd Sdhc Sdhb mt-Nd1 Sdha mt-Nd2 mt-Nd3 Ndufa12 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dhdds Nus1 Srd5a3 Dolk Dhrsx PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Adss1 Pfas Ak8 Atic Ppat Paics Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Adsl Impdh1 Guk1 Gart Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk2 Nmrk1 Nmnat3 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glul Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls Pgd UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Pdss1 Ubiad1 Coq2 Coq3 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Impdh1 Nme1 Guk1 Gmps Nme7 Nme6 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme3 Nme2 Nme5 Nme4 Guk1 Nme1 Nme7 Nme6 Ak5 Dguok Dck THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Asns Gls2 Gls VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gstz1 Gsta5 Gsta3 Anpep Gstm7 Ggt5 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Mgst3 Gstt2 Mgst2 Gstt1 Mgst1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Ptgs2 Alox5 Lta4h PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Azin2 Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Pcyt2 Cept1 Etnk1 Chkb Selenoi CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis Carns1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox12 Gpx4 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Crym Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Hyal4 Hyal1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b ATP6 Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp5pf Atp6v1c1 Atpaf2 Atp6v1a Atp6v1b2 Atp6v0d1 Vps9d1 Atp5mc3 Atp5mf Atp5me Atp6v0e1 Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Fpgs Shmt2 Shmt1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Mvk Pmvk PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Bdh2 Acat1 Bdh1 Hmgcs2 Hmgcl D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Dcxr Cryl1 Akr1a1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4k2b Plcz1 Plce1 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Plcb4 Plcb3 Plcb2 Plcb1 Pi4k2a Plcg1 Plcg2 Pip4k2b Pip4k2c Pip4k2a Pi4kb Pi4ka Plch2 Plch1 Plcd1 Plcd4 Plcd3 Cdipt ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Aldh3a2 Acss2 Acss1 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Acat1 Acat2 Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Elovl7 Fads1 Fads2 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt1 B3gnt5 B3gnt2 Fut2 Fut1 A4galt B4galt4 B4galt6 B4galnt1 Gbgt1 St3gal6 St3gal4 St3gal5 St3gal2 B4galt1 B4galt2 B4galt3 B3galnt1 St6gal1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B4galt1 B4galt2 B4galt3 St6gal1 St8sia2 St8sia3 Ugcg B3gnt5 B3gnt2 B4galt4 B4galt6 St3gal6 St3gal4 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation Mtap NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt Nadk CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Chdh Aldh7a1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk1 Chkb Selenoi Gnpat Pcyt1b Pcyt1a Agps Far2 Far1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Afmid Haao Got2 Aldh8a1 Kyat3 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Dhtkd1 Aadat Kyat1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Hsd17b1 Hsd17b7 Cyp2a5 Cyp19a1 Hsd17b11 Hsd17b3 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St6gal1 B3galt4 B4galt6 Ugcg B4galnt1 St8sia1 St3gal5 St3gal2 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt1 Abo B3galt5 Fut2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Akr1b10 Cyp2e1 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat2b Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Itpk1 Ipmk GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Cbr1 Ptgs2 Tbxas1 Hpgds Hpgd Akr1c18 Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Ocrl Pip4p2 Pten Pip4p1 Inpp5k Synj2 Sacm1l Inppl1 Inpp5e Mtmr14 Inpp4a Mtmr3 Inpp4b Tpte Inpp5d Inpp5f Synj1 Inpp5b ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcs Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Alox12 Gpx4 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ptgs2 Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ggt5 Gstm4 Ephx3 Alox8 Alox12 Dpep2 Gpx4 Alox5 Cyp4f15 Dpep1 Cyp2j6 Alox15 Cyp4f3 Ltc4s Cyp2d22 Lta4h PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Ocrl Pten Inpp5k Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ppip5k2 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio1 Dio3 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd1 Txnrd3 Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Ptgs2 Alox5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Bdh2 Acat1 Bdh1 Oxct1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Dera Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Maoa Cyp1b1 Cyp2c50 Cyp1a2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Dhtkd1 Aldh8a1 Acmsd GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx1 Gpx3 Gsr Gpx7 Gpx4 Gpx2 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nampt Nmnat1 Nmnat3 Nmnat2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Mboat1 Abhd5 Mboat2 Agpat1 Agpat3 Lclat1 Agpat4 Agpat2 Cds2 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm Minpp1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Fa2h Hacl1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Fbp2 Bpgm Gpi Tpi1 Pcx Mdh1 Mdh2 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc2 G6pc3 EG433182 Pgk1 Pgam2 Pgam1 Pgk2 Fbp1 Pck1 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc2 Aldh2 Aldh3a2 Aoc3 Maoa Maob PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Elovl7 Tecr Elovl1 Hsd17b12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Hsd17b12 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggt5 Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ntpcr Ctps2 Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Pygl Pygm Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Pygb Mgam Hkdc1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Hibch Acad8 Bckdhb Hibadh Bckdha Aldh6a1 Dbt Bcat1 Dld Abat Bcat2 Echs1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Metap2 Ntan1 Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Ptgs2 Alox5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1 Got1l1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Hkdc1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 AI597479 Rtraf Tsen54 Fam98b Zbtb8os Tsen2 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tyms Tk1 Dck PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm1 Dut Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Dtymk Nme7 Nme6 Ntpcr L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Aldh18a1 Pycr2 Pycr1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta5 Gsta3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5c1a Nt5e Nt5c3a Impdh1 Pnp Gda Xdh Nt5c2 Ada L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Ahcy Mat2a Mat2b Mat1a Cbs Cth L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Mtap Mat2a Srm Mat2b Mat1a Enoph1 Adi1 Kyat1 Mri1 Apip D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Impa2 Ocrl Impa1 Inpp5k Inpp1 Synj2 Inppl1 Inpp5f Inpp5a Synj1 Inpp5b Bpnt2 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Bmpr1b Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ggt5 Gstm4 Dpep2 Alox5 Dpep1 Ltc4s Lta4h PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b6 Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp1 Xdh Rbp4 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Aldh3a2 Maoa Comt Maob MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1 Got1l1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis Gal3st1 Ugt8 St3gal5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldha Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Aldh2 Aldh3a2 Aldh1b1 Aldh3b1 Aldh3a1 Maoa Sat2 Sat1 Maob CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckmt2 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Mccc2 Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Mccc1 Auh Hmgcl Ivd GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Got1 Aga Aspg Asrgl1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Sult1a1 Aldh2 Aldh3a2 Maoa ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adss1 Ak8 Adsl Ak1 Ak3 Ak2 Ak5 Adss2 Ak7 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Haao Kmo Tdo2 Kynu Ido2 Ido1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcz1 Plce1 Plaat3 Plaat1 Plaat5 Pla2g2e Pla2g4f Plcb4 Pla2g2d Plcb3 Pla2g2f Pla2g4c Pla2g4e Pla2g4d Pld4 Plcb2 Pla2g4a Pld1 Plcb1 Plb1 Pld3 Pld2 Pla2g12a Pnpla8 Plcg1 Pla2g5 Plcg2 Pla2g3 Pla2g6 Pla2g1b Oc90 Pla2g10 Plch2 Plch1 Plcd1 Plcd4 Plcd3 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Got1 Gclc Gss Gclm COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcs Pank3 Ppcdc Pank2 Coasy Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldob Aldoc Tkfc Aldoa Sis Khk Tpi1 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Tk2 Tyms Tk1 Nme3 Nme2 Nme5 Nme4 Cmpk2 Cda Nme1 Cmpk1 Dtymk Nme7 Nme6 Dck PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chka Cept1 Chkb Pcyt1b Pcyt1a Chpt1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Afmid Haao Akr1a1 Nmnat1 Aldh8a1 Kmo Tdo2 Nmnat3 Nmnat2 Kynu Ido2 Maoa Acmsd Ido1 Maob Dhtkd1 Aldh2 Sult1a1 Aanat Tph2 Ddc Tph1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Gcdh Cyp1a2 Echs1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acox2 Scp2 Hsd17b4 Acaa1a Hadh Hsd17b10 Acsbg1 Ehhadh Slc27a2 Echs1 Acox1 Acsbg2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Ddc Aldh3a2 Akr1a1 Maob TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Vars1 Farsa Farsb Cars2 Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Iars2 Tars1 Ears2 Hars1 Pars2 Mars1 Mars2 Dars2 Yars2 Yars1 Hars2 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage Pdxk Pnpo N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda1 Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Adss1 Ak8 Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Pnp Aprt Hprt1 Ada Adsl Impdh1 Guk1 Adk Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Rrm1 Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Dctd Nme1 Dtymk Nme7 Nme6 Ntpcr UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 Ctps2 Ctps1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Dmgdh Chdh Aldh7a1 Shmt2 Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Ogdh Aco2 Sucla2 Dld Mdh1 Mdh2 Fh Sdhd Idh3a Sdhc Dlst Sdhb Idh3b Sdha Cs Idh3g Suclg1 Suclg2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Scp2 Hadh Hadha Hsd17b10 Hadhb Acaa2 Eci1 Acsbg1 Slc27a2 Echs1 Acsbg2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis B3galt1 B3gnt5 St6gal1 B3galt5 Fut2 B4galt6 Ugcg St3gal5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd2 Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Afmid Haao Aldh8a1 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Rbp1 Aldh1a2 Rdh16f2 Aldh1a1 Aldh1a3 Sdr16c5 Rbp4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide B4galt1 B4galt2 B4galt3 Abo Fut1 St8sia2 Fut9 Chst1 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Dpys Upp1 Dpyd Upp2 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio1 Dio3 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4galt1 B4galt2 B4galt3 B3gnt2 Gcnt3 Gcnt2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pfkm Pfkp Bpgm Gpi Tpi1 Hk3 Hkdc1 Gapdhs Aldob Aldoc Hk2 Eno3 Gck Eno2 Hk1 Aldoa EG433182 Pgk1 Pgam2 Pgam1 Pklr Pgk2 Pfkl Pkm HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4galt1 B4galt2 Lalba St6galnac6 St6gal1 B3gnt2 B3galt5 Fut2 B4galt4 Gcnt3 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh1 Pnp Xdh Nt5c2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 Tyrp1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Oxsm Acsf3 Mcat Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation Faah FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galnt1 B3galt5 Fut2 Fut1 A4galt B4galt6 Ugcg Gbgt1 St3gal2 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk2 Gck Hk1 Treh Hk3 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rpe65 Rbp1 Rbp2 Rbp3 Rdh5 Dhrs9 Lrat Rlbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Srd5a1 Srd5a2 Akr1c18 Cyp17a1 Hsd3b6 Hsd3b1 Hsd17b3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Impdh1 Guk1 Nme1 Nme7 Gmps Nme6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rbp1 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ptgs2 Ephx3 Alox12 Gpx4 Alox5 Alox15 Cyp2d22 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cb Pik3cd Pik3ca Pi4k2b Pik3c2b Pik3c2a Pik3c2g Fig4 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Pikfyve Pik3c3 Sacm1l Pi4k2a Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r3 Pik3r4 Pi4kb Pi4ka Cdipt Pik3cg UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpnat1 Uap1 Gnpda1 Pgm3 Hk2 Gck Gnpda2 Hk1 Gpi Hk3 Gale Hkdc1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis Hkdc1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Elovl7 Elovl6 Acot7 Acsl1 Hsd17b12 Acsbg1 Acot2 Slc27a2 Acot3 Acsbg2 Acot4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Aldh4a1 Got2 Hoga1 Prodh2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f15 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Acsbg1 Ptgr1 Slc27a2 Acsbg2 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Pgm2 Ada PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4p2 Pip4p1 Plcb2 Plcb1 Plcz1 Plce1 Plcg1 Plcg2 Mtmr14 Mtmr3 Pip4k2c Pip4k2a Plch2 Plch1 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c21 Srd5a1 Akr1c6 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Mthfd2l Aldh1l1 Mthfsl Aldh1l2 Mthfd2 Mthfr Shmt2 Shmt1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat2b Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt1 Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx1 Gpx3 Gpx7 Gpx6 Cat Gpx5 Gpx8 Sod3 Gpx2 Sod2 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5c1a Nt5e Nt5c3a Pnp Xdh Nt5c2 Ada ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Akr1b10 Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Bbox1 Aldh9a1 Shmt1 Tmlhe 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Ocrl Inpp5k Synj2 Inppl1 Ippk Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Itpk1 Ipmk LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox8 Alox12 Gpx4 Alox5 Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Daglb Cel Pnliprp2 Pnlip Lipc Pnpla2 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat3 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis Cox10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Elovl7 Fads2 Elovl2 Elovl5 Hsd17b12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4galt1 B4galt2 B4galt3 St6gal1 B3gnt2 St8sia2 Gcnt3 Gcnt2 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Aldh2 Aldh3a2 Cyp2e1 Acss2 Acss1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Aldh3a2 Acss2 Acss1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Mcee Pcca Pccb Mmut LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1 Lct Glb1l3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Fmo3 Fmo2 Fmo5 Cyp2a5 Fmo4 Cyp4x1 Cyp2u1 Cyp2s1 Ugt1a5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Pgm1 Galt Galm Galk1 Pgm2 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk2 Gck Hk1 Gpi Gfpt1 Hk3 Gfpt2 Hkdc1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Atic Adsl Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Dhtkd1 Aadat Aldh7a1 Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sephs1 Sepsecs Sars2 Sars1 Pstk Sephs2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Phyh Acsm1 Aldh3a2 Hacl1 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis Glul TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw1 Lcmt2 Tyw3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Plaat1 Gde1 Enpp2 Plaat5 Pla2g1b VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acat1 Acat2 Acsm1 Acadsb Echs1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Afmid Haao Nmnat1 Kmo Tdo2 Nmnat3 Kynu Nmnat2 Ido2 Qprt Ido1 Nadsyn1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl1 Acsl3 Acsbg1 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Plcb1 Daglb Ddhd1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Trmt112 Aqp9 Slc34a2 Aqp7 Slc2a1 Pnp Hemk2 Slc20a2 Slc20a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp2b10 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation Adh5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Ugp2 Pgm2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Ptgs2 Alox5 Lta4h ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gpi Gmppb Mpi Pmm1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss UREA CYCLE%BIOCYC%PWY-4984 urea cycle Otc Asl Cps1 Ass1 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Dmgdh Shmt2 Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Sqor Suox Tst HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas1 Alas2 Fech Hmbs Cpox Uros Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pcca Pccb Mmut L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Sds Bckdha Dbt Sdsl Dld GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Pnp Hprt1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Nos3 Nos2 Nos1 Asl Ass1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Got1 Bckdhb Bckdha Cbs Dbt Cth Dld Bhmt Mcee Pcca Bhmt2 Mtr Pccb Mmut Suox Cdo1 Ahcy Mat2a Mat2b Mat1a TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas1 Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Acat1 Hmgcr Acat2 Mvd Hmgcs2 Idi1 Mvk Pmvk TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Ppcs Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat1 Plpp4 Plpp2 Plpp3 Plpp1 Mogat1 Dgat2 Plppr4 Dgat1 Plppr2 Gpat4 Plppr3 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Agpat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis Flad1 Rfk D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Minpp1 Itpk1 Ipmk CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh Pnmt 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw1 Tyw3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Cdo1 Fmo1 Csad ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Got1 Mdh1 Mdh2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Fosb Cd44 Runx2 Kat2b Rb1 Mapk14 Tgfbr3 Prkar2a Pml Ski Map2k3 Mef2a Mef2c Brca1 Zfyve9 Rock1 E2f4 Tgfbr1 Cdkn1a E2f5 Tgfbr2 Atf2 Mapk8 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Myc Cdc27 Akt1 Sox9 Cdc23 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d1 Nup153 Trp73 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Vdr Trp53 Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Nup214 Smad3 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Tab1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Xpo4 Ctcf Hdac1 Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Eng Lef1 Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Nfyc Prkar1b Ep300 Strap Map2k6 BDNF%IOB%BDNF BDNF Ptk2b Irs2 Elk1 Gsk3b Ntrk2 Ntrk1 Mapk3 Raf1 Akt1 Mapk9 Mapk8 Shc4 Mapk7 Shc1 Irs1 Mapk1 Foxo3 Plcg1 CCR1%IOB%CCR1 CCR1 Pxn Ptk2b Mapk3 Ccr1 Zap70 Creb3 Mapk14 Src Gna14 Rela Ccl7 Ccl5 Ccl4 Ccl3 Nfkb1 Stat1 Prkcd Ptk2 Mapk1 LEPTIN%IOB%LEPTIN Leptin Stat3 Grb2 Lepr Mapk3 Mapk14 Prkcd Irs1 Irs2 Sp1 Pik3r1 Pik3r2 Pde3a Itgav Socs7 Ncoa3 Ptpn11 Slc2a4 Jak3 Jak2 Egfr Ptk2 Khdrbs1 Itgb5 Mapk1 Lep Prkce THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Map2k1 Stat5b Atxn2l Mpl Mapk3 Gab1 Jak2 Shc1 Mapk1 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Akt1 Mapk14 Prkcb Shc1 Plcg1 Gsk3b Raf1 Src Rela Stat1 Jun Ptpn11 Jak3 Jak2 Grb2 Stat5b Socs1 Mitf Socs5 Socs4 Matk Socs6 Crkl Ptpru Gys1 Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Grb7 Rasa1 Was Eif4ebp1 Cbl Mtor Epor Csf2rb2 Abl1 Fyn Grap Lyn Kitlg Pik3r1 Yes1 Crk Pik3ca Pik3r2 Stat5a Tec Fes Hras Atf2 Mapk8 Ep300 Mapk1 CCR7%IOB%CCR7 CCR7 Ptk2b Foxo1 Gsk3b Mapk3 Mtor Mapk14 Akt1 Rela Cfl1 Ccr7 Adrb2 Mapk8 Mapk1 Foxo3 Plcg1 WNT%IOB%WNT Wnt Ctnnb1 Pi4k2a Map3k7 Rac1 Ppp1ca Nfatc2 Sfrp2 Arrb2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Akt1 Dkk1 Mesd Pax2 Gsk3a Frzb Dixdc1 Chd7 Axin1 Prkcg Ror1 Ror2 Prkcb Gckr Lrp1 Arhgef4 Prkcd Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Gpc3 Dvl3 Wnt7a Wnt2 Wnt1 Gsk3b Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd5 Jup Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Fzd8 Smad1 Bcl9 Apc Jun Pin1 Tcf4 Pip5k1b Ccnd1 Cdk6 Rhoa Prkca Yes1 Lef1 Ilk Mark2 Mapk8 Sox1 Wnt5a Ctbp1 Cdh1 Setdb1 Ywhab FAS%IOB%FAS Fas Bcl2 Rac1 Fas Pkn2 Pkn1 Vim Dffa Mapk3 Cdk11b Cdc27 Akt1 Rock1 Prkcd Csnk1a1 Gsk3b Traf3 Psme3 Faf1 Eif2ak2 Arhgdib Stk24 Map3k5 Xpo5 Parp1 Traf2 Traf1 Dedd2 Plec Csnk2b Map2k1 Prkn Parg Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif3j2 Eif4b Gtf3c3 Lck Tcp1 Daxx Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Max Srf Aifm1 Uso1 Ptpn6 Uba7 Stk4 Stk3 Prkdc Rasa1 Ripk2 Fasl Numa1 Hspb1 Cflar Eif2s1 Bid Pak2 Fyn Ube4b Casp8 Lyn Casp7 Tial1 Mbd4 Tia1 Casp9 Casp4 Casp3 Casp6 Fastk Satb1 Casp2 Casp1 Ripk1 Bmx Map2k2 Wee1 Diablo Mapk1 Pdcd6 Bax ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rac1 Vim Erbb2 Clca1 Rpsa Ywhah Akt1 Ywhae Erbin Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Prkcd Pik3r3 Col17a1 Itga6 Trp73 Ntn1 Ephb2 Pak1 Shc1 Lamb2 Irs1 Lamb3 Pik3cg Sfn Irs2 Lamb1 Pik3cb Pik3cd Rtkn Bad Eif6 Lamc1 Ar Lamc2 Src Ptpn11 Egfr Ptk2 Smad2 Grb2 Plec Smad3 Rhoa Met Prkca Eif4ebp1 Mtor Abl1 Fyn Pik3r1 Yes1 Pik3ca Pik3r2 Casp3 Ywhab NGF%IOB%NGF NGF Elk1 Map2k1 Mapk3 Creb1 Dnaja3 Prkci Frs2 Mapk1 Sp1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ctnnb1 Sap18b Sufu Gas1 Kif27 Arrb2 Prkaca Ywhae Med23 Dhh Ihh Gli1 Gli3 Gli2 Shh Grk2 Ptch2 Ptch1 Dyrk1a Boc Med12 Med1 Hhip Stk36 Med6 Cdk8 Smo GM-CSF%IOB%GM-CSF GM-CSF Bcar1 Mapk3 Akt1 Mapk14 Tgfbr3 Gsk3a Map2k3 Mapk9 Shc1 Plcg1 Pxn Elk1 Gsk3b Bad Raf1 Creb1 Tgfb1 Stat1 Jak2 Stat3 Grb2 Map2k1 Ikbkb Stat5b Pdia3 Csf2ra Slc2a1 Gab1 Prdx3 Stam2 Syk Rack1 Vav1 Sptan1 Crkl Rps6ka2 Ezr Pfn1 Csf2 Ganab Stam Cct5 Dpysl2 Hck Ptprc Sh2b2 Nfkbia Bcl3 Hnrnph1 Park7 Prkca Chuk Ptpn6 Cbl Csf2rb2 Lyn Pik3r1 Yes1 Pik3r2 Stat5a Fes Mapk8 Map2k2 Mapk1 Map2k6 CCR9%IOB%CCR9 CCR9 Cd226 Foxo1 Itgb7 Ccl25 Gsk3b Itga4 Ccr9 Mapk3 Mapk14 Akt1 Ezr Mapk8 Rdx Cdh1 Madcam1 Mapk1 Msn TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Grb7 Elk1 Map2k1 Stat5b Nos3 Tie1 Mapk3 Raf1 Dok2 Tek Nck1 Mapk14 Akt1 Stat5a Fes Bmx Map2k2 Ptk2 Pak1 Shc1 Mapk1 CCR5%IOB%CCR5 CCR5 Stat3 Grb2 Ikbkb Mapk3 Akt1 Mapk14 Syk Nfkbia Chuk Ptpn6 Ptk2b Psma5 C5ar1 Afp Rela Ccl11 Ccl7 Cd4 Ccl5 Ccl12 Ccl4 Pik3r1 Ccl2 Ccr5 Stat5a Stat1 Cfl1 Mapk1 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Stat3 Stat5b Akt1 Vav1 Eif4b Crkl Map2k3 Prkcd Nfkbia Irs1 Foxo1 Irs2 Eif4ebp1 Cbl Mtor Zap70 Crk Stat5a Stat6 Stat1 Stat4 Erbb3 Pla2g4a Ifnar1 Ifnar2 Jak1 Arhgap30 Tyk2 Prkcq Map2k4 Rps6ka5 Stat2 Map2k6 TRAIL%IOB%TRAIL TRAIL H2ax Ctnnb1 Dap3 Map3k7 Bex3 Chek2 Ikbkg Tnfrsf11b Mapk3 Prkaa1 Tradd Bak1 Bcl10 Xiap Akt1 Mcl1 Mapk14 Vdac1 Tnfsf10 Apaf1 Irf5 Atm Fadd Nfkbia Tnfrsf10b Aifm1 Prkdc Cbl Cflar Bid Creb1 Src Casp8 Rela Casp7 Nfkb1 Casp3 Casp2 Casp1 Ripk1 Diablo Mapk1 Parp1 Ctsb Traf2 Bax NOTCH%IOB%NOTCH Notch Mapk3 Kat2b Skp1 App Sin3a Rbx1 Fhl1 Hivep3 Hdac2 Mfng Hey1 Numb Ccn3 Skp2 Sap30 Hes6 Tle1 Maml3 Notch4 Fbxw7 Notch1 Notch2 Notch3 Gsk3b Psen1 Pofut1 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Rela Dll1 Dll3 Dll4 Itch Maml1 Smad1 Nfkb1 Ring1 Maml2 Hes1 Furin Jag2 Jag1 Cirsr Rbpj Yy1 Jak2 Lfng Tcf3 Stat3 Smad3 Smad4 Cul1 Hdac1 Lef1 Ep300 Mapk1 M-CSF%IOB%M-CSF M-CSF Grap2 Stat3 Tfe3 Grb2 Gab3 Pstpip2 Dnm1 Stat5b Vim Csf1 Mitf Akt1 Fadd Prkcd Shc1 Ptk2b Inpp5d Cbl Casp8 Pik3r1 Stat5a Ptpn11 Ripk1 Ets2 Ptk2 Csf1r Myo18a Inppl1 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Trp53 Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Mapk7 Shc1 Plcg1 Ptk2b Irs2 Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Grb7 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Pik3ca Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Erbin Dsp Itgb4 Ywhaz Pik3r3 Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Tyk2 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Myl12b Il17rd Pard3 Mprip Prkd1 Elk4 Eps8 Gja1 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 S100a14 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Garem1 Pik3c2b mt-Co2 Antxr1 Arf4 Braf Shb Clta Pgam1 Cyld Ldha Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl1 Appl2 EG433182 Caskin2 Stx4 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Socs3 Atxn2 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Eps15 Map3k3 Magi1 Map3k2 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp4 Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Serpinb3d Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Acp1 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Sos2 Ctnnal1 Ubash3b Wbp2 Atp1a1 Sri Ephb1 Cebpb Cebpa Ephb3 Ephb4 Ahcyl1 Hnrnpa1 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Sh2b1 Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Rin1 Tln1 Vasp Arhgef7 H3c8 Hnrnpr Sdc4 Sdc3 Insr Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Pdcd6ip Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Ptprk Dcbld2 Ptprf Git1 Rps27l Vav3 Laptm4a Cdv3 Plekha6 Plekha5 Vav2 Mink1 Actn1 Prpf4b Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Wasl Cttn Mpzl1 Axl Ctnnd1 Nedd9 Huwe1 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 Peak1 Afap1l2 Ddx3x Sfpq Pdpk1 Dapp1 Iqgap1 Asap1 Anks1 Asap3 Baiap2 Lsr Epn2 Epn1 Dyrk4 Rps6ka3 Epn3 Dock4 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Egf Spry2 Spry3 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Cdc25b Nono Trim68 Ncoa1 Bag1 Gtf2h1 Psmc3ip Rbak Cdk11b Ccnd3 Runx2 Nelfcd Kat2b Pelp1 Rb1 Cdk9 Xrcc6 Cdk7 Hspa5 Xrcc5 Mdm2 Fhl2 Pias3 Pou2f1 Prmt1 Brca1 Rac3 Rnf14 Calr Nr0b2 Spdef Etv5 Efcab6 Lpxn Svil Ddc Il6st Tmf1 Arnt Hsp90b1 Zmiz2 Zmiz1 Gsk3b Rnf4 Foxa1 Magea13 Ncoa2 Ncoa6 Nsd2 Nsd1 Src Pnrc1 Pak6 Rela Stub1 Tgfb1i1 Slc25a4 Vip Rchy1 Ran Ncoa3 Egfr Stat3 Cebpa Rack1 Pten Park7 Ccne1 Ctnnb1 Ppp1ca Akt1 Sin3a Cdc25a Pxn Ar Ncor2 Sp1 Jun Tcf4 Ccnd1 Cav1 Esr1 Hspa8 Parp1 Smad3 Smad4 Prkd1 Daxx Top1 Tgif1 Hdac1 Hspb1 Brinp1 Nr2c2 Nr2c1 Nrip1 Ahr Hsp90aa1 Casp8 Uxt Casp7 Pias4 Kat5 Pik3r1 Ube2i Kat7 Gtf2f2 Gtf2f1 Casp3 Pias1 Sf1 Appl1 Ccnh Prdx1 Tle5 Casp1 Patz1 Dapk3 Flna Gsn Cdc37 Pa2g4 Ep300 Ranbp9 Senp1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Stat3 Cbl Mapk3 Gab1 Cebpa Creb1 Akt1 Lyn Stat5a Flt3 Jun Cblb Gab2 Atf2 Mapk1 CD40%IOB%CD40 CD40 Stat3 Map2k1 Ikbkb Mapk3 Myc Mapk14 Syk Akt1 Fyn Lyn Lck Pik3r1 Plcg2 Jun Fgr Nfkbia Jak3 Mapk9 Mapk8 Chuk Mapk1 TNFSF3%IOB%TNFSF3 TNFSF3 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Lta Ltb Ltbr Traf2 ID%IOB%ID ID Id2 Id1 Elk1 Id4 Smad3 Id3 Myf5 Tcf7l2 Rbl2 Rb1 Rbl1 Cdk2 Elk4 Hes1 Tcf3 Myod1 Psmd4 Atf3 Pax5 Elk3 G-CSF%IOB%G-CSF G-CSF Stat3 Grb2 Stat5b Il3ra Mapk3 Csf3r Pom121 Fth1 Pla2g1b Socs3 Akt1 Mapk14 Syk Syp Cdk2 Rel Cish Cdkn1b Csf3 Lck Hck Csnk1e Rps6ka1 Shc1 Inpp5d Cbl Prkci Lyn Stat5a Stat1 Gab2 Ptpn11 Jak1 Jak2 Tyk2 Mapk1 EPO%IOB%EPO EPO Stat3 Map2k1 Stat5b Mapk3 Gab1 Akt1 Syk Vav1 Gsk3a Crkl H2bc7 Hcls1 Sgk1 Sh2b2 Foxo4 Foxo3 Foxo1 Irs2 Bad Nos3 Raf1 Mtor Braf Epor Stat5a Jun Ptpn11 Jak2 Map2k2 Rps6ka5 Mapk1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat3 Cebpb Mapk3 Akt1 Mapk14 Crkl Spi1 Plcg2 Ifngr1 Hoxa10 Irf1 Irf2 Irf8 Mapk11 Cbl Raf1 Crk Stat5a Stat6 Stat1 Pla2g4a Jak1 Mapk8 Jak2 Prkcq Egfr Mapk1 TNFSF1%IOB%TNFSF1 TNFSF1 Ikbkg Akt1 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Tnfrsf14 Lta Ltbr TNFALPHA%IOB%TNFALPHA TNFalpha Pkn1 Map3k14 Rb1 Cdk9 Ywhah Mapk14 Ywhae Pml Map3k3 Ywhaz Map3k2 Map3k1 Mapk9 Creb1 Src Rela Nfkb1 Stat1 Traf5 Relb Tnfrsf1b Tnfrsf1a Ptpn11 Nfkb2 Egfr Ikbkb Gab1 Syk Rel Rack1 Dok1 Nfkbia Bcl3 Rpl4 Nkiras1 Nkiras2 Chuk Tbkbp1 Trib3 Map3k8 Nlrp4e Rps11 Tnf Fbl Unc5cl Tbk1 Tnfrsf11a Akt2 Dpf2 Kcnq1 Azi2 Polr1b Ppp1r13l Polr1c Polr1a Usp2 Polr1d Polr1e Stat5a Fbxw11 Txlna Tank Gtf2i Hsp90ab1 Actl6a Smarce1 Tifa Mark2 Mapk8 Cdc34 Rasa3 Nfkbiz Papola Rps6ka5 Mapk1 Glg1 Bag4 Ywhab Sec16a Map3k7 Ripk3 Cradd G3bp2 Dcaf7 Ikbkg Cops3 Mapk3 Nfkbib Nfkbie Tradd Kpna6 Kpna3 Akt1 Ccnt1 Tab3 Tab2 Skp1 Traf7 Traf4 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Hdac2 Psmd12 Ube2d3 Copb2 Map2k5 Prkcd Smarcb1 Psmd13 Alpl Rasal2 Btrc Akap8 Hdac6 Iqgap2 Psmb5 Peg3 Fbxw7 Bcl7a Ppp6c Nupr1 Fkbp5 Smarca4 Mcm5 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Psmd6 Mapkapk2 Jun Fancd2 Cops5 Psmd3 Psmd2 Traf3 Elp1 Psmd1 Cav1 Faf1 Ktn1 Spag9 Usp11 Glb1 Smarcc2 Prc1 Ddx3x Smarcc1 Crebbp Traf2 Rnf25 Traf1 Map3k11 Tnfaip3 Lrpprc Mtif2 Cul1 Tab1 Fadd Hdac1 Prkcz Hspb1 Brinp1 Cflar Nr2c2 Bid Hsp90aa1 Casp8 Casp7 Ube2i Casp3 Casp2 Ripk1 Flna Cdc37 Map2k6 GDNF%IOB%GDNF GDNF Pxn Ptk2b Bcar1 Map2k1 Ret Th Raf1 Cdc25c Gab1 Rps6ka3 Fyn Cdk1 Crk Jun Met Dok1 Nfkbia Map2k2 Ptk2 TNFSF8%IOB%TNFSF8 TNFSF8 Traf1 Nfkb1 Tnfrsf8 Relb Traf3 Nfkb2 Bcl3 Akt1 Rel Rela Mapk1 CXCR4%IOB%CXCR4 CXCR4 Bcar1 Rac1 Arrb2 Mapk3 Vav2 Map2k3 Prkcd Plcg1 Pxn Ptk2b Elk1 Gsk3b Bad Zap70 Creb1 Src Rela Nfkb1 Stat1 Ptpn11 Jak3 Jak2 Egfr Ptk2 Hspa8 Stat3 Map2k1 Ikbkb Stat5b Itk Cxcr4 Itgb2 Icam1 Gnai1 Vav1 Tff2 Lcp2 Crkl Rps6ka2 Cxcl12 Lck Gna13 Grk6 Fyb1 Plcg2 Ackr3 Cblb Esr2 Rhoa Vcam1 Limk1 Ptprc Usp14 Dok1 Nfkbia Chuk Foxo3 Ptpn6 Inpp5d Rasa1 Was Cbl Nck1 Fyn Lyn Pik3r1 Crk Sdc4 Ccr5 Pik3r2 Stat4 Cfl1 Map2k2 Mapk1 Stat2 Ywhab CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 Il4 Cabin1 Pou2f1 Ifng Fasl Cd40lg Akap5 Nfatc1 Csf2 Junb Nfatc3 Ptgs2 Nfatc2 Rcan1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Jun Fos Atf2 Il10 Sin3a Sin3b Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Tgif2 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Tfdp1 Foxo3 Foxo1 Creb1 Sap30 Col1a2 Tfe3 Dcp1a Rbl1 Itgb5 Sap18b Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Ncor1 Dlx1 Nr3c1 Myod1 Max Ep300 Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Cited1 Sp3 Runx3 Runx2 Kat2b Kat2a Cbfb Vdr Rbbp4 Rbbp7 Esr1 Hspa8 Crebbp Ski Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 E2f4 Tcf3 Cdkn1a E2f5 Smad7 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Nfkbia Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il12b Il18 Il18rap Il19 Cd3e Tnf Mpo Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Cxcl3 Jak2 Il12rb1 Pik3ca Tyk2 Nos2 Il24 Il17f Il23a Rela Il17a SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Ranbp2 Hdac4 Ube2i Mdm2 Pias1 Ran Pias2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Jun Pik3r1 Fos Mapk8 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Itgb3 Rock2 Chuk Pip5k1a Map3k14 Nfkb1 Pik3ca Rela ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Fkbp1a Mapk1 Mapk3 Smad4 Smad7 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 Eng SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Jun Pxn Irs2 Grb10 Gdnf Ptpn11 Prkaca Pik3r1 Gfra1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Mapk8 Dok5 Mapk1 Dok6 Grb2 Prkca Mapk3 Sos1 Rhoa Crk Bcar1 Hras Rac1 Creb1 Pik3ca Ret Grb7 Shank3 Shc1 Src SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Prkaca Mapk1 Mapk3 Fgf15 Col11a1 Col11a2 Cask Ccl5 Bsg Hpse Ppib Col2a1 Mmp9 Sdcbp Col3a1 Mmp7 Col1a1 Col6a1 Col5a2 Col4a3 Tgfb1 Col4a4 Col7a1 Col6a2 Hgf Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Col1a2 Fgf23 Fgfr3 Fgfr4 Mmp1a Lama5 Sdc1 Met REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Plce1 Lgals1 Lgals3 Rasgrf1 Rasgrf2 Nras Prkcb Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Sos2 Grb2 Prkca Sos1 Hras Rasa2 Rasa4 Rabgef1 Camk2b Rasal1 Nf1 Dab2ip Kras Prkcz Syngap1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Aurkb Incenp IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Stat5a Pik3r1 Il4 Cd40lg Socs1 Spi1 Stat6 Alox15 Ets1 Socs5 Myb Il10 Jak3 Aicda Jak1 Il13ra1 Il13ra2 Arg1 Bcl2l1 Fcer2a Mybl1 Dok2 Itgb3 Irf4 Lta Oprm1 Tff3 Inpp5d Akt1 Ptpn6 Thy1 Ccl17 Cbl Mtor Selp Ccl11 Gtf3a Col1a2 Pigr Mapk14 Egr2 Parp14 Il2rg Stat5b Bcl6 Fes Il4ra Hmga1 Retnlg Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Pik3ca IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Tert Lck Bcl2 E2f1 Ugcg Il2ra Ptpn11 Pik3r1 Il2 Grb2 Sos1 Myb Rac1 Jak3 Jak1 Bcl2l1 Myc Akt1 Mtor Foxo3 Il2rg Nfkb1 Pik3ca Smpd1 Il2rb Eif3a Hsp90aa1 Shc1 Sgms1 Prkcz Rela Gab2 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Il2ra Nras Stat1 Prkaca Pik3r1 Il2 Ifng Rhoa Jak3 Jak1 Il2rg Il2rb Shc1 Gab2 Irs1 Lck Bdnf Afdn Ptpn11 Kdr Angpt1 Lmo4 Gab1 Ngf Frs2 Frs3 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Grb2 Ntf4 Sos1 Ntf3 Pdgfrb Ifngr1 Hras Vegfa Pdgfb Pag1 Arhgap35 Nos3 Egf Igf1 Ntrk2 Map2k2 Ntrk1 Map2k1 Il6ra Ntrk3 Tek Igf1r Il6 Jak2 Pik3ca Kras NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Gata1 Ep300 Cdkn1b E2f1 Ar Stat3 Ncoa1 Kdr Runx2 Crebbp Myb Tcf3 Ctbp1 Spen Hdac1 Neurog3 Ncor2 Arnt Ptf1a Camk2d Ghr Hif1a Maml1 Hey2 Cd4 Maml2 Hey1 Parp1 Hes1 Twist1 Ascl1 Rb1 Jak2 Hes6 Tle1 Gaa Rbbp8 Kdm1a Rbpj Ncor1 Yy1 Notch1 Gata6 Rcan1 Myod1 Gata4 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga7 Itga8 Itgax Itga5 Itga6 Itga9 Itgam Itga4 Itga1 Itga2 Itgae Itgal Itga10 Itga11 Itgad Itgb8 Itgav Itgb6 Itgb7 Itgb1 Itga2b Itgb4 Itgb2 Itgb3 Itga3 Itgb5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Rhoa Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Ppp1r12a Fzr1 Pak1 Rock2 Ect2 Tubg1 Bub1 Cdc14b Cdc20 Ppp1cb Ppp2ca Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Wee1 Ppp2r1a Prc1 Cdk1 Bub1b Btrc Ninl Kiz Cdc25c Aurka Cenpe Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ccne1 Cstf1 Bard1 Prkdc Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad51 Rad50 Pcna Fancd2 Ewsr1 Trp53 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Ube2l3 Cdk2 Rbbp8 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Rhoa Gna12 Gnaz Gnao1 Gnai2 Gnai1 S1pr5 Gnai3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Stat5a Nras Pik3r1 Gab1 Ngf Grb2 Sos1 Hras Camk4 Ywhah Ntrk1 Ywhag Ywhae Pdpk1 Camk2a Ywhab Trpc3 Trpv1 Akt1 Agap2 Sfn Egr1 Bad Foxo3 Ccnd1 Plcg1 Creb1 Gsk3b Prkcd Ywhaz Pik3ca Kras Shc1 Src IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Jun Il18r1 Stat3 Il2ra Fos Il2 Ifng Pias2 Mapk8 Crebbp Stat4 Tgfb1 Il18 Il18rap Cd3e Cd4 Mapk9 H2-Eb1 Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Tbx21 Etv5 Irf1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Klhl9 Kif2c Ppp2r5d Smc4 Smc2 Birc5 Evi5 Ncaph Ppp1cc Npm1 Cbx5 Cdca8 Racgap1 Ncapd2 Septin1 Incenp Tacc1 Mylk Aurkb Des Nsun2 Pebp1 Rhoa Klhl13 Cul3 Vim Kif23 Kif20a Bub1 Sgo1 Aurka Psma3 Cenpa Stmn1 Ndc80 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Pik3r1 Nck1 Ptk2 Mapk1 Mapk3 Rhoa Bcar1 Rac1 Ntn1 Dock1 Elmo1 Fyn Yes1 Trio Dcc Map2k2 Map1b Wasl Map2k1 Dapk1 Pak1 Unc5b Camk2a Myo10 Unc5a Unc5c Agap2 Plcg1 Pik3ca Src S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 S1pr4 Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Gna12 Gnaz Gnao1 Gnai2 S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Map2k1 Mapk1 Pde3b Pik3cg Pik3r6 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Gata1 Cdkn1b Nras Ube2i Spi1 Ets1 Ptgs2 Myb Sin3a Pias3 Myc Adora2b Ccna1 Slc25a3 Birc3 Prtn3 Col1a2 Map3k7 Ets2 Clta Tfec Pim1 Iqgap1 Cdkn2a Rag2 Gata3 Ppid Atp2b1 Pax5 Zfpm1 Snd1 Ncor1 Maf Ptcra Kit Myod1 Smarca2 Mcm4 Ep300 Cd34 Bcl2 Lef1 Cebpb Mat2a Trim28 Cebpd Nlk Cebpa Sp1 Elane Csf1r Gstm2 Yeats4 Copa Wnt1 H2az1 Ppp3ca Kitlg Cbx4 Casp6 Anpep Mad1l1 Hspa8 Hras Crebbp Ca1 Ski Zfhx3 Cdk6 Lect2 Myf6 Tab2 Tab1 Hipk2 Ada Cdkn1a Ccnd1 Mpo Cd4 Hes1 Kras EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Pxn Nras Pik3r1 Rras Nck1 Rap1a Ptk2 Mapk1 Grb2 Mapk3 Crk Hras Rac1 Ephb1 Ephb2 Wasl Map2k1 Ephb3 Map4k4 Pak1 Ephb4 Tf Efnb1 Efnb2 Efnb3 Rap1b Synj1 Dnm1 Itsn1 Rock1 Kalrn Efna5 Pik3ca Grb7 Kras Shc1 Src FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Ezr Mapk10 Mapk11 Pik3r1 Fasl Mapk8 Syk Map3k1 Pdpk1 Chuk Akt1 Birc3 Ikbkb Mapk9 Birc2 Mapk14 Ikbkg Map2k7 Map2k6 Cltc Cflar Faim2 Pik3cb Bid Pik3ca Casp8 Smpd1 Rfc1 Casp3 Ripk1 Btk Fas Src Fadd PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Bcl2 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Tnfrsf1a Bag4 Raf1 Mapk8 Tradd Mapk1 Cradd Pdgfa Traf2 Mapk3 Ksr1 Prkra Eif2a Map2k4 Sphk2 Bax Egf Igf1 Map2k2 Map3k1 Map2k1 Map4k4 Myc Akt1 Bad Tnf Birc3 Prkcd Nfkb1 Rb1 Bid Casp8 Smpd1 Ripk1 Prkcz Rela Fadd ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Ppp2r5d Fkbp1a Ube2l3 Blk Pld1 Plcb2 Fyn Syk Klk6 Yes1 Pld2 Ptk2b Grk5 Th Tor1a Sncaip Slc6a3 Lyn Prkn Uchl1 Maob Stub1 Fgr Hck Bad Park7 Snca Prkcd Src ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Nfkbia Lck Pik3r1 Arrb2 Bcl3 Rel Ikbkb Mapk14 Nfkb1 Pik3ca Btrc Syk Rela Src RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Pkn2 Ezr Jun Pkn1 Cdkn1b Sh3gl2 Tln1 Pip5k1c Pip5k1b F2rl2 Fos Vcl Scai Mapk8 Rhoa Itgb1 Map2k4 Atf2 Pld1 Pld2 Ppp1r12a Rock2 Pip5k1a Rock1 Srf Ccn1 Slc9a1 Acta1 Mapk12 Map2k6 Pard6a Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Myl2 Limk1 Prkcz Limk2 Mrtfa SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Stat5a Stat3 Pik3r1 Rhoa Itga2b Bcar1 Blk Fyn Yes1 Itgb3 Lyn Akt1 Fgr Hck Cav1 Stat5b Shc1 Src Irs1 Lck Ins2 Prl Csf1r Ybx1 Prlr Egfr Cdh2 Dok1 Fcgr3 Csn2 Csf1 Insr Grb2 Trpv6 Txn Crk Ptpn1 Pdgfrb Csk Capn1 Pdgfb Spry2 Fer Lep Nox4 Egf Lat Lepr Socs3 Jak2 Pik3ca Tyk2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Ezr Prkaca Itga2 Mapk8 Mapk1 Sdc2 Csf2 Mapk3 Rhoa Itgb1 Hras Fgf15 Bax Cask Mmp2 Fn1 Kng2 Tnfrsf13b Sdcbp Ephb2 Cav2 Trappc4 Rack1 Epb41 Lama1 Lama3 Tgfb1 Prkcd Fgf23 Fgfr3 Fgfr4 Nf1 Casp3 Src RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Map2k1 Nras Ptpn7 Prkcb Braf Fos Map3k8 Elk1 Raf1 Mapk1 Prkca Mapk3 Hras Kras ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Jun Mapk11 Fos Pou2f1 Ifng Mapk8 Mapk1 Mapk3 Junb Cul3 Atf2 Mmp2 Arg1 Bcl2l1 Th Plau Creb1 Mapk14 Atf3 Ep300 Bcl2 Ins2 Cbfb Prkca Esr1 Brca1 Cdk4 Socs3 Hrk Ccna2 Ccnd1 Hbb-bh1 Serpinb5 Kat5 Il6 Ache Mapk9 Macroh2a1 Ddit3 Col24a1 Hes1 Jdp2 Ruvbl2 Csrp2 Rb1 Jund Gadd45a Sele Dusp5 Tgfb2 Nos2 Dusp1 Nf1 Pdgfra Il23a Dusp10 Dusp8 Ppargc1a EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna1 Efna2 Lck Efna3 Arhgef15 Crkl Ngef Epha1 Epha2 Epha3 Vav2 Epha4 Epha5 Epha6 Epha7 Cdk5 Epha8 Rhoa Crk Blk Vav3 Fyn Yes1 Lyn Fgr Pik3cg Hck Cbl Pik3r6 Plcg1 Rock1 Efna5 Src SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Gata1 Nfkbia Stat3 Prkaca Ranbp2 Hdac4 Ube2i Tnfrsf1a Ran Nr2c1 Smg5 Prmt5 Hdac3 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Sin3a Fkbp3 Sin3b Pparg Chd3 Chd4 Sirt3 Sirt2 Hdac2 Sirt1 Smurf1 Wdr77 Sirt7 Gata2 Sirt6 Hdac1 Sirt5 Sirt4 Hdac11 Hdac10 Mta2 Tfcp2 Mbd3 Mbd2 Gatad2a Sap30 Mxd1 Gatad2b Sap18b Btrc Zfpm1 Ncor1 Max Ep300 Kat2b Rbbp4 Rbbp7 Crebbp Smad7 Ncor2 Tnf Nfkb1 Yy1 Rela ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Vamp3 Exoc1 Itga7 Nme1 Itga8 Exoc2 Dnm2 Pip5k1c Itga5 Spag9 Itga6 Avpr2 Itga9 Exoc7 Bin1 Ins2 Itga4 Ctnnd1 Itga1 Mapk8ip3 Itga2 Cpe Arf6 Itga10 Itga11 Itgav Itgb1 Pld1 Pld2 Ctnnb1 Klc1 Tshr Itga3 Cdh1 Asap2 Cltc Agtr1a Slc2a4 Adrb2 Scamp2 Acap1 Rala Exoc3 Exoc4 Ctnna1 Exoc5 Exoc6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ep300 Cdkn1b Mapk10 Csnk1a1 Ran Csnk1g3 Fasl Kat2b Mapk8 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Ralb Mst1 Crebbp Sod2 Usp7 G6pc1 Rbl2 Cat Csnk1d Sgk1 Cdk2 Csnk1e Ywhah Sirt1 Ywhag Ywhae Chuk Ywhab Akt1 Foxo4 Sfn Plk1 Foxo3 Foxo1 Ikbkb Ywhaz Mapk9 Ctnnb1 Bcl6 Gadd45a Rala SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Sgpl1 Gna15 Gna14 Abcc1 Gnaq Sphk1 Gna13 S1pr1 S1pr3 S1pr4 S1pr2 Sgpp1 Gnai1 Gnai3 Sphk2 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1b Prkdc Prkaca Raf1 Bcl2l1 Ywhah Ywhag Ywhae Pdpk1 Cdkn1a Chuk Ywhab Akt1 Foxo4 Sfn Rictor Bad Mtor Map3k5 Foxo3 Akt3 Foxo1 Akt2 Gsk3b Casp9 Tbc1d4 Ywhaz Kpna1 Mapkap1 Gsk3a Mlst8 Slc2a4 Hsp90aa1 Src E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Nme1 Pip5k1c Afdn Pik3r1 Rap1a Vav2 Ctnnd1 Itgae Arf6 Itgb7 Rhoa Crk Rac1 Akt1 Rap1b Ccnd1 Ctnnb1 Cdh1 Tiam1 Nckap1 Iqgap1 Klhl20 Ap1m1 Wasf2 Pik3ca Jup Cttn Tjp1 Dlg1 Ctnna1 Rapgef1 Cyfip2 Src Abi1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Stil Dhh Hhip Ihh Lrp2 Gli2 Hhat Pik3r1 Shh Akt1 Grk2 Lrpap1 Smo Arrb2 Ptch2 Ptch1 Boc Gas1 Pthlh Cdon Pik3ca Tgfb2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk4 Plk2 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Jun Stat5a Stat3 Racgap1 Mapk8 Ncf1 Ncf2 Brk1 Arhgdia Bcar1 Noxa1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Plcb2 Actr3 Arhgap5 Pak2 Wasf1 Map3k1 Arpc3 Noxo1 Arpc2 Pak1 Cyba Abi2 Cybb Pip5k1a Arpc5 Arpc4 Map3k11 Nox1 Ctnnb1 Mapk14 Cdh1 Iqgap1 Cfl1 Map2k3 Ctnna1 Limk1 Pip5k1c Pip5k1b Crk Mapk9 Map2k7 Map2k6 Nckap1 Wasf2 Cyfip2 Abi1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Arr3 Cnga3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Rdh5 Gnb3 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef6 Spata13 Fgd1 Nme1 Arhgef9 Git1 Ngef Dnmbp Mcf2 Arhgap17 Dock10 Dock11 Vav2 Ralbp1 Farp2 Racgap1 Dock6 Bcar3 Arhgef25 Apc Arhgap1 Itsn2 Arhgdia Vav3 Itsn1 Plcg1 Arhgef7 Mcf2l HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Efna1 Ep300 Kdr Sp1 Adora2a Flt1 Epo Eif3e Ets1 Bhlhe40 Vegfa Crebbp Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Sirt1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Arnt Elk1 Twist1 Serpine1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Jun Mdm2 Pou2f1 Mapk8 Nr2c1 Hdac7 Map2k4 Sirt1 Gata2 Hdac1 Foxo1 Rel Mapk14 Hsp90aa1 Nr3c1 Src Smarca2 Ep300 Pkn1 Ar Ncoa2 Ncoa1 Cebpa Kat2b Crebbp Rack1 Hoxb13 Nr2c2 Kat7 Nr0b1 Egr1 Spdef Rxrb Rxra Gsk3b Smarce1 Kat5 Ehmt2 Rxrg Senp1 Carm1 Dnaja1 Zmiz2 Map2k6 Trim24 Appbp2 Pde9a Smarcc1 Tmprss2 Rchy1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jun Crkl Pik3r1 Fos Elk1 Plcg1 Cav1 Srf Grb2 Itgav Sos1 Crk Pik3ca Cav3 Jak1 Shb Shf Pdgfra Rapgef1 Shc1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncan Ptn Mc4r Pomc Psen1 Agrp Egfr Fgf23 Fgfr3 Fgfr4 Fgf15 Cask Cttn Fyn Ncstn Aph1b Src Sdc3 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Jun Mapk11 Cebpb Gdi1 Eif4ebp1 Pla2g4a Mitf Rab5a Elk4 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Trp53 Eif4e Mapkapk5 Mef2a Esr1 Rps6ka4 Rps6ka5 Ptgs2 Hbp1 Atf2 Mknk1 Atf6 Mef2c Creb1 Slc9a1 Mapk14 Ddit3 Nos2 Ppargc1a ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Pxn Tln1 Git1 Prkaca Itga4 Ptk2 Arf6 Itgb1 Crk Bcar1 Spp1 Rac1 Prkar1a Dock1 Prkar1b Mdk Jaml Fn1 Jam2 Ptk2b Cd81 Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Ywhaz Src Abi1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Fzd8 Dkk1 Ror2 Wnt1 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Fzd10 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd7 Fzd6 Kremen1 Fzd9 Rspo1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Fosl1 Jun Cdkn1b Fos Il2 Il4 Ifng Nfatc1 Csf2 Junb Nfatc3 Ets1 Nfatc2 Atf2 Myb Il10 Mmp9 Th Plau Gata2 Myc Tgfb1 Creb1 Ccn1 Col1a2 Ctnnb1 Acta1 Cdkn2a Cdk1 Pten Atf3 Maf Nr3c1 Ep300 Dmp1 Gja1 Edn1 Elf1 Penk Il5 Trip6 Sp1 Dmtf1 Mt2 Nts Mafg Crtc1 Bag1 Fosb Bcl2l11 Tcf7l2 Cbfb Cops5 Trp53 Fabp4 Timp1 Esr1 Agt Nppa Fosl2 H2-Q10 Egr1 Ccnd1 Hif1a Il6 Ccl12 Mmp1a Jund Dusp1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Stat5a Lyn Ptpn11 Pik3r1 Il5 Grb2 Stat5b Pim1 Jak2 Pik3ca Csf2rb2 Il5ra Cish Sdcbp INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Arhgef6 Jun Pxn Ilk Rac1 Myl12a Ilkap Ruvbl1 Rhog Ppp1r14a Ppp1r12a Ppp1r14c Ppp1r14b Elmo2 Nck2 Tns1 Git2 Parvg Akt1 Tacc3 Snai1 Lims2 Rictor Zeb1 Ccnd1 Actn1 Parvb Creb1 Gsk3b Zyx Cdc37 Parva Ctnnb1 Ckap5 Parp1 Ruvbl2 Diaph1 Iqgap1 Aurka Hsp90aa1 Arhgef7 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gja1 Pip5k1c Ptpn11 Pik3r1 Ctnnd1 Cdh2 Mapk8 Rhoa Ptpn1 Rac1 Fer Gsn Lrp5 Plcg1 Rock1 Ctnnb1 Daglb Camk2g Mapre1 Dctn1 Gap43 Kif5b Cnr1 Pik3ca Fgfr1 Jup Gria2 Cttn Dagla Axin1 Myl2 Ctnna1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Rarg Thrb Thra Bcl2 Nr1h4 Nr1h3 Nr1h2 Ncoa1 Ppard Ppara Abca1 Nr4a1 Srebf1 Vdr Pparg Tgfb1 Ncor2 Rxrb Tnf Rxra Rxrg Fam120b Rara Rarb Med1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Jun Stat5a Ctsd Hdac4 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Pdia2 Anp32a Ddx17 Ap1b1 Ddx54 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Trim59 Dscam Pgr Axin2 Ncoa7 Chuk Myc Atp5pf Hdac1 C3 Mta1 Greb1 Hsf2 Ncoa3 Xbp1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Ncor1 Ep300 Cebpb Ncoa2 Ncoa1 Lmo4 Prl Pcna Esr1 Brca1 Smad4 Ncor2 Nr0b1 Ccnd1 Med1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Stat5a Itga5 Pik3r1 Mapk8 Mapk1 Mapk3 Itgb1 Ets1 Rac1 Fyn Mmp2 Pld2 Dok2 Pak1 Akt1 Foxo1 Mapk14 Grb14 Fgf2 Angpt2 Stat5b Angpt4 Agtr1a F2 Fes Elf2 Tnip2 Plg Bmx Grb7 Shc1 Rasa1 Pxn Elf1 Ptpn11 Angpt1 Nck1 Ptk2 Grb2 Crk Nos3 Fn1 Cdkn1a Tek Elk1 Tnf Nfkb1 Pik3ca Rela DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Fosl1 Jun Il2ra Nras Prkcb Fos Prkce Il2 Ifng Fasl Mapk8 Mapk1 Nfatc1 Mapk3 Junb Nfatc3 Nfatc2 Il2rg Tnfrsf4 Il2rb Prkcq Tnfrsf9 Ifna16 B2m Gzmb Ifnar1 Eomes Ifnar2 Egr4 Cd8a Cd8b1 Tnfrsf18 Raf1 Prkca Hras H2-Q10 Map2k2 Map2k1 Stat4 Ptpn7 Braf Elk1 Egr1 Cd3e Tnf Mapk9 Cd3g Cd247 Prf1 Cd3d Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Jun Itga5 Pik3r1 Rras Mapk8 Mapk1 Itgav Rhoa Itgb1 Ets1 Bcar1 Map2k4 Rac1 Dock1 Elmo1 Fyn Yes1 Wasl Pak1 Rock2 Acta1 Itgb5 Bmx Grb7 Arhgef7 Src Rasa1 Pxn Tln1 Vcl Arhgef11 Nck1 Asap1 Rap1a Arhgef28 Mapk8ip3 Sh3gl1 Arhgap26 Ptk2 Capn2 Raf1 Klf8 Ptpn21 Grb2 Sos1 Crk Arhgap35 Map2k1 Nck2 Git2 Braf Rap1b Actn1 Ccnd1 Plcg1 Mapk9 Pik3ca Rapgef1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb2 Lama2 Lamb3 Lama5 Lamb1 Lama1 Lamc2 Lama3 Itgb4 Itga6 Lamc1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 H2ax Ube2t Blm Atm Chek1 Rad9a Top3a Wdr48 Fanci Fancm Usp1 Fancb Palb2 Rfc5 Rfc3 Rfc4 Faap100 Rfc2 Rpa1 Rpa2 Hus1 Rad17 Atrip Brip1 Cenps Fbxw11 Brca2 Xrcc3 Rad1 Faap24 Fan1 Hes1 Btrc VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Rrad Krt14 Wwp1 Rab38 Krt5 Nrg1 Cebpd Mre11a Adrm1 Il1a Axl Fbxw7 Perp Trp63 Top2a Mdm2 Vdr Hbp1 Fosl2 Atm Ada Rack1 Sfn Col5a1 Gsk3b Brca2 Yap1 Itga3 Hes1 Dlx5 Bdkrb2 Ppp2r5a Hells Cdkn2a Igfbp3 Itch Sec14l2 Stxbp4 T Fasn Tcf7l1 Notch1 Pou2f2 Ccnb2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Madd App Arhgdib Tnfrsf1a Slk Tradd Cfl2 Xiap Cradd Sptan1 Traf2 Lmna Apaf1 Gas2 Top1 Tfap2a Vim Numa1 Lmnb1 Bax Lmnb2 Pidd1 Gsn Casp7 Krt18 Casp4 Satb1 Map3k1 Casp2 Casp1 Diablo Dffa Dffb Birc3 Acta1 Limk1 Gzmb Bcl2 Ptk2 Casp6 Tnf Casp9 Birc2 Parp1 Prf1 Bid Casp8 Casp3 Ripk1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Arhgef6 Spata13 Rasgrf1 Rasgrf2 Ngef Mcf2 Arhgap17 Vav2 Ralbp1 Racgap1 Dock6 Arhgef25 Arhgap1 Sos1 Arhgdia Rac1 Dock1 Vav3 Elmo1 Trio Tiam2 Arhgef2 Dock2 Abr Eps8 Def6 Rap1gds1 Prex1 Vav1 Bcr Kalrn Arhgap9 Tiam1 Arhgef7 Abi1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Tln1 Itgam Rap1a Rhoa Mst1 Itgb2 Mmp2 Jam2 Mmp9 Plau Myh2 Thy1 Rap1b Hck Tnf Selp Rock1 Il6 Lrp1 Selplg Ccn2 Jam3 Plat Nfkb1 Ager Icam1 Plaur Mst1r Apob Plg ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pip5k1a Arf6 Kalrn Mapk1 Mapk3 Tiam1 Rhoa Plaur Rac1 Arf1 Pld1 Rab11fip3 Rab11a Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Jun Prkcb Pik3r1 Fos Pla2g4a Mapk8 Mapk1 Mapk3 Nfatc2 Map2k4 Syk Fyn Pld2 Pak2 Map3k1 Lyn Chuk Inpp5d Akt1 Cbl Vav1 Itk Plpp1 Fcer1a Shc1 Klrg1 Gab2 Hcls1 Rasa1 Cblb Wipf1 Pxn Fcer1g Lat2 Lcp2 Ptpn11 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Ptk2 Dok1 Raf1 Grb2 Sos1 Hras Fer Lat Map2k2 Map2k1 Sphk1 S1pr1 Plcg1 Ikbkb Ikbkg Map2k7 Nfkb1 Pik3ca Dusp1 Btk Rela S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Cxcr4 Gnai1 Gnai3 Mapk1 Flt1 Mapk3 Rhoa Pdgfrb Vegfa Pdgfb Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Gna13 Akt1 S1pr3 Akt3 Jak2 Src A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Itgb7 Itgb1 Rhoa Itga4 Madcam1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Rasgrf1 Crkl Stat3 Nras Pik3r1 Mapk1 Mapk3 Rhoa Rac1 Dock1 Elmo1 Shc1 Mcf2l Gab2 Rasa1 Bdnf Ptpn11 Rap1a Gab1 Ngf Frs2 Frs3 Matk Sqstm1 Faim Prkci Maged1 Ngfr Grb2 Dnaja3 Ntf4 Sos1 Shc3 Ntf3 Crk Shc2 Gipc1 Hras Rgs19 Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Ntrk2 Rhog Ntrk1 Map2k1 Ntrk3 Rap1b Dnm1 Ccnd1 Plcg1 Tiam1 Pik3ca Kras Rapgef1 Prkcz CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Nras Pik3r1 Rap1a Arf6 Rhoa Hras Rac1 Blk Fyn Syk Lat Yes1 Cyth2 Sgk1 Zap70 Cyth3 Cyth1 Dapp1 Pdpk1 Inppl1 Lyn Plekha2 Plekha1 Plcg2 Inpp5d Blnk Arap3 Fgr Adap1 Pik3cg Hck Arf5 Pik3r6 Foxo3 Plcg1 Pik3cb Pik3ca Arf1 Pten Itk Hsp90aa1 Kras Btk Src ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Stat5a Wwp1 Nrg1 Pik3r1 Prl Mdm2 Prlr Mapk1 Grb2 Mapk3 Fyn Tab2 Wwox Erbb2 Erbb4 Lrig1 Adam17 Ereg Hbegf Nrg2 Yap1 Btc Cbfa2t3 Stat5b Nrg4 Nrg3 Jak2 Dlg4 Pik3cb Grin2b Itch Pik3ca Ncor1 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Stat5a Stat3 Nras Stat1 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk1 Grb2 Csf2 Mapk3 Sos1 Hras Csf2rb2 Cish Syk Map2k2 Prkacb Map2k1 Lyn Inpp5d Ikbkb Ywhaz Ccl12 Pim1 Stat5b Jak2 Csf2ra Pik3ca Osm Irf8 Kras Shc1 Gab2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Pkn1 Mapk12 Map2k6 Mapk13 Map2k3 Ccnd1 Eef2k Map3k20 Snta1 Stmn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Vasp Efna1 Aqp5 Kifc3 Mgat3 Aqp3 Git1 Pip5k1c Nectin2 Lpp Afdn Myo6 Epha2 Vcl Stx4 Nck1 Plekha7 Ctnnd1 Camsap3 Egfr Arf6 Rhoa Egf Igf1 Igf1r Hgf Actn1 Rock1 Zyx Ctnnb1 Cdh1 Diaph1 Nckap1 Met Exoc3 Exoc4 Myl2 Ctnna1 Cyfip2 Lima1 Abi1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Mapk11 Prkaca Prkcb Pik3r1 Myof Cdh5 Ptprj Camkk2 Akap1 Mapkapk2 Mapk1 Sh2d2a Hsp90ab1 Itgav Hgs Mapk3 Ptpn2 Rhoa Vtn Fyn Pak2 Ptk2b Itgb3 Akt1 Ptpn6 Cbl Fbxw11 Cav1 Ctnnb1 Mapk14 Iqgap1 Fes Arf1 Map2k3 Hsp90aa1 Ctnna1 Src Pxn Grb10 Dnm2 Ptpn11 Kdr Vcl Nck1 Gab1 Ptk2 Raf1 Grb2 Prkca Flt1 Vegfa Nos3 Map2k2 Map2k1 Pdpk1 Nck2 Braf Plcg1 Rock1 Prkcd Map2k6 Pik3ca Shb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Fosl1 Birc5 Npm1 Eif4e Riox2 Peg10 Bmi1 Ndufaf2 Bax Bcat1 Ddx18 Trrap Shmt1 Taf12 Rcc1 Mmp9 Hspd1 Prdx3 Supt3 Cad Nme2 Myc Taf4b Mtdh Actl6a Mta1 Ldha Cdc25a Serpini1 Odc1 Taf9 Eif4g1 Gpam Rpl11 Id2 EG433182 Eif2s1 Supt7l Pfkm Pim1 Lin28b Myct1 Ccnd2 Tfrc Polr3d Hmga1 Pdcd10 Hspa4 Ireb2 Eif4a1 Hsp90aa1 Ubtf E2f3 Tk1 Tert Max Huwe1 Ep300 Nme1 Nbn Kat2a Trp53 Crebbp Smad3 Smad4 Slc2a1 Ruvbl1 Cdk4 Snai1 Kat5 Ruvbl2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp16 Lck Traf6 Mapk11 Pak3 Prkg1 Map3k3 Ccm2 Map3k12 Ralb Map2k4 Rac1 Blk Fyn Yes1 Tab1 Pak2 Pak1 Lyn Fgr Hck Mapk14 Map2k6 Rala Dusp1 Map2k3 Ripk1 Dusp10 Dusp8 Src SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Stat5a Crkl Stat3 Stat1 Pik3r1 Mitf Mapk8 Socs1 Mapk3 Lyn Akt1 Ptpn6 Cbl Foxo3 Vav1 Pten Shc1 Kit Bcl2 Grb10 Ptpn11 Stap1 Ptpro Gab1 Spred1 Spred2 Matk Epor Dok1 Grap2 Raf1 Pik3c2b Snai2 Sh2b2 Kitlg Sh2b3 Grb2 Map4k1 Sos1 Tec Epo Hras Crebbp Fer Map2k2 Map2k1 Pdpk1 Bad Gsk3b Jak2 Pik3ca GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Mapk9 Bmp4 Fgf7 Gpc3 Shh Furin Ptch1 Mapk8 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Pxn Itga9 Csf2 Itgb1 Bcar1 Vegfa Spp1 Rac1 Tnc Adam12 Adam15 Sat1 Vegfd Fn1 Vegfc Tgm2 Paox Adam2 F13a1 Adam8 Vcam1 Kcnj15 Csf2ra Nos2 Src DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Prkdc Pnkp Polm Nhej1 Dntt Aptx Dclre1c Lig4 Aplf Xrcc4 Poll Xrcc6 Xrcc5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Jun Crkl Pik3r1 Eif4ebp1 Rab5a Ptprj Mapk8 Mapk1 Eif4e Hgs Mapk3 Ptpn2 Rhoa Ets1 Bcar1 Map2k4 Rac1 Pak2 Map3k1 Wasl Pak1 Inpp5d Akt1 Cbl Mtor Ctnnb1 Cdh1 Pard6a Ctnna1 Shc1 Gab2 Src Sh3gl2 Pxn Ptpn11 F2rl2 Nck1 Rap1a Gab1 Arf6 Ptk2 Raf1 Prkci Apc Grb2 Sos1 Crk Ptpn1 Hras Map2k2 Map2k1 Pdpk1 Inppl1 Nck2 Rap1b Snai1 Hgf Egr1 Bad Plcg1 Akt2 Rptor Kpnb1 Numb Sh3kbp1 Eps15 Mlst8 Ranbp9 Rin2 Met Arhgef4 Deptor Pak4 Akt1s1 Pik3ca Muc20 Ranbp10 Rapgef1 Prkcz EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Tln1 Stat3 Pip5k1c Nras Stat1 Ptpn11 Pik3r1 Nck1 Gab1 Ptk2 Egfr Gnai1 Gnai3 Mapk1 Grb2 Mapk3 Sos1 Ptpn1 Hras Gsn Egf Wasl Pak1 Nck2 Ptpn6 Plcg1 Pik3cb Pik3ca Kras Shc1 Src PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Vasp Grk3 Snx2 Pkn1 Gng2 Snx1 Arrb1 Dnm2 Akap13 Prkcg Prkcb Pik3r1 F2rl2 Gnb1 Gnai1 Gnai3 Prkca Rhoa Arhgdia Gna12 Gnaz Nos3 Gnao1 Plcb2 Gnai2 Gna11 Gna15 Gna14 Rock2 Gnaq Gna13 Dnm1 Rock1 Zyx Prkcd F2 Pik3ca Plcb3 F2r Myl2 Arhgef1 Plcb1 Trpc6 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Dnm2 Itga5 Cxcl12 Sdc4 Fgf6 Cxcr4 Nudt16l1 Tfpi Ptk2 Prkca Rhoa Itgb1 Gipc1 Rac1 Tnc Adam12 Ccl5 Mdk Fn1 Mmp9 Tnfrsf13b Sdcbp Lama1 Lama3 Thbs1 Actn1 Prkcd Fgf2 F2 Fgfr1 Plg Fzd7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Smyd2 Cse1l Mapk8 Kat8 Fbxo11 Ppp1r13l Prmt5 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Ccng1 Chek2 Setd7 Cop1 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Daxx Akt1 Ppp2ca Rpl11 Mapk14 Nedd8 Cdkn2a Huwe1 Ep300 Trim28 Csnk1a1 Csnk1g3 Kat2b Csnk1g1 Csnk1g2 Trp53 Skp2 Crebbp Atm Usp7 Chek1 Abl1 Csnk1d Hipk2 Csnk1e Cdk2 Ccna2 Gsk3b Kat5 Prkcd Mapk9 Rchy1 Yy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Fosl1 Jun Cblb E2f1 Egr4 Il2ra Il5 Fos Batf3 Il2 Il4 Pou2f1 Ifng Fasl Cd40lg Nfatc1 Csf2 Junb Ptpn1 Nfatc3 Ptgs2 Nfatc2 Pparg Cdk4 Rnf128 Ctla4 Irf4 Ptprk Dgka Slc3a2 Egr3 Ikzf1 Foxp3 Egr1 Tnf Egr2 Gata3 Itch Tbx21 Casp3 Prkcq Maf E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Jun Gna15 Irs1 Gna14 Pak1 Gnaq Gna13 Fos S1pr2 Elk1 Cdh5 Gnai1 Mapk8 Gnai3 Mapk14 Mapk1 Mapk3 Rhoa Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Gng2 Ar Pik3r1 Fos Gnb1 Ptk2 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Rac1 Gnaz Gnao1 Plcb2 Gnai2 Map2k2 Map2k1 Plcg2 Akt1 Gnrh1 Shbg Pelp1 Plcg1 Creb1 Pik3ca Plcb3 Plcb1 Src PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Plk3 Trp53 Chek2 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Fosl1 Ep300 Jun Gja1 Sp1 Dmtf1 Nfatc1 Junb Nfatc3 Nfatc2 Itgb4 Fosl2 Nos3 Mmp2 Mmp9 Plau Lama3 Ccna2 Ccnd1 Hmox1 Txlng Il6 Usf2 Col1a2 Lif Ccl12 Dcn Thbd Mmp1a Mgp Atf4 Jund Cdkn2a Plaur ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Trim28 Mre11a Nbn Mdm2 Rad50 Fancd2 Brca1 H2ax Blm Atm Chek2 Abl1 Rad9a Top3a Cop1 Ctbp1 Ywhab Cdc25a Dclre1c Rad17 Xrcc4 Kat5 Mdc1 Terf2 Smc3 Ube2n Abraxas1 Bid Rbbp8 Uimc1 Trp53bp1 Smc1a Cdc25c HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Nfkbia Bcl2 Tnfrsf1a Bag4 Fasl Mapk8 Tradd Cradd Traf2 Casp6 Apaf1 Casp7 Casp2 Daxx Chuk Map3k14 Map3k5 Tnf Birc3 Casp9 Map2k7 Cd247 Nfkb1 Cflar Bid Casp8 Casp3 Traf1 Ripk1 Rela Fas Fadd ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Sftpa1 Myd88 Ly96 Tlr1 Chuk Vcan Saa2 Cd14 Irak4 Ticam1 Tlr6 Tirap Tlr4 S100a9 S100a8 Tlr3 Tlr2 Ikbkb Ikbkg Rhoa Irak2 Irak1 Bgn Hspd1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Stat5a Il1b Stat3 Stat1 Il2 Ifng Ebi3 Il6st Il12a Il12rb2 Il27 Il27ra Stat2 Jak1 Stat4 Tgfb1 Il12b Il18 Tnf Il6 Jak2 Il12rb1 Gata3 Tyk2 Tbx21 Il17a P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Mapk10 Psen1 Pik3r1 App Mapk8 Xiap Apaf1 Rhoa Arhgdia Rac1 Prkacb Diablo Chuk Akt1 Birc3 Plg Shc1 Irak1 Myd88 Traf6 E2f1 Bdnf Ngf Sqstm1 Prkci Bcl2l11 Maged1 Ngfr Trp53 Ntf4 Ntf3 Casp6 Rhoc Rhob Lingo1 Furin Mmp3 Omg Mag Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Ntrk1 Rtn4 Ywhae Mmp7 Ripk2 Ndn Prdm4 Sort1 Zfp369 Bad Adam17 Casp9 Ikbkb Mapk9 Birc2 Ikbkg Pik3ca Casp3 Ncstn Aph1b Prkcz CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Pip5k1b Nkd2 Ranbp3 Dvl1 Lrp6 Klhl12 Dvl2 Dvl3 Pi4k2a Cav1 Gsk3b Csnk1g1 Apc Wnt3a Ctnnb1 Gsk3a Ppp2r5a Cul3 Fzd5 Axin1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Jun Stat1 Ptpn11 Pik3r1 Fos Ctnnd1 Gab1 Frs2 Cdh2 Runx2 Mapk1 Sdc2 Grb2 Mapk3 Sos1 Fgf15 Spp1 Spry2 Ptk2b Mmp9 Plau Pdpk1 Camk2a Akt1 Cbl Plcg1 Klb Il17rd Fgf1 Fgf23 Ncam1 Fgfr3 Fgfr4 Ssh1 Fgfr2 Cdh1 Rps6ka1 Stat5b Plaur Pak4 Pik3ca Fgfr1 Cttn Shc1 Src ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Tlx2 Smad9 Fkbp1a Amhr2 Amh Bmp7 Smad5 Smad4 Bmpr2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Mak Cmtm2b Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Pawr Snurf Ube2i Appl1 Hnrnpa1 Pias1 Ncoa6 Ccnd3 Nrip1 Kdm3a Tgfb1i1 Tcf4 Vav3 Gsn Pias3 Ptk2b Tgif1 Pias4 Akt1 Pelp1 Srf Ctnnb1 Uba3 Cdkn2a Prkdc Ar Ncoa2 Xrcc6 Brca1 Xrcc5 Cdk6 Ccnd1 Carm1 Ranbp9 Hip1 Lats2 Tmprss2 Fhl2 Casp8 Kdm4c Kdm1a Znf318 Prdx1 Fkbp4 Patz1 Med1 Rps6ka3 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Vasp Pip5k1a Pik3r1 Akt1 Ctnnd1 Plcg1 Egfr Akt2 Zyx Ctnnb1 Casr Ajuba Cdh1 Rhoa Rac1 Pik3ca Jup Fyn Ctnna1 Src IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Jun Mapk11 Cebpb Stat3 Stat1 Cebpd Ptpn11 Pik3r1 Fos Mitf Lmo4 Gab1 Pias1 Il6st Grb2 Crp Timp1 Junb Sos1 Hsp90b1 Lbp Mcl1 Map2k4 Rac1 Ptpre Fgg Tnfsf11 Jak1 A2m Pias3 Bcl2l1 Il6ra Myc Socs3 Akt1 Hck Foxo1 Vav1 Il6 Prkcd Mapk14 Map2k6 Jak2 Pik3ca Tyk2 Irf1 Gab2 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Efna5 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Mdm2 Rad51 Fancd2 Topbp1 Chek1 Rad9a Mcm7 Smarcal1 Ppp2r2b Timeless Cdk2 Cep164 Cdc6 Rfc5 Tipin Rfc3 Mcm2 Rfc4 Ywhab Rfc2 Rpa1 Rpa2 Hus1 Cdc25a Ppp2ca Rad17 Plk1 Atrip Ccna2 Clspn Fbxw11 Brca2 Rad1 Ywhaz Ppp2r1a Btrc Cdc25c DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Cul1 Skp1 Dvl1 Lrp6 Dvl2 Dvl3 Csnk1a1 Gsk3b Apc Wnt3a Ctnnb1 Gsk3a Fzd5 Btrc Axin1 Csnk1d Csnk1e IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Irs2 Grb10 Crkl Ptpn11 Pik3r1 Ptk2 Raf1 Grb2 Sos1 Ptpn1 Crk Bcar1 Hras Igf1 Ywhae Pdpk1 Rack1 Nck2 Igf1r Prkd1 Akt1 Bad Prkcd Ywhaz Pik3ca Shc1 Prkcz CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Casp1 Map2k1 Pgr Vcam1 Il1b Nlrp1a Antxr2 Il18 Antxr1 Tnf Mapk1 Map2k7 Map2k6 Mapk3 Map2k4 Map2k3 Map2k2 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Gnb1 Gngt1 Slc24a1 Rdh12 Pde6a Pde6b Rgs9bp Gnat1 Cnga1 Pde6g Rho Sag Grk1 Gucy2e Rpe65 Rdh5 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccne1 Ep300 Birc5 Fos Sp1 Gas1 Aurkb Skp2 Nfatc3 Esr1 Crebbp Chek2 Mmp2 Cdk4 Cdk2 Map2k1 Myc Plk1 Ccna2 Ccnd1 Brca2 Cenpb Gsk3a Hspa1a Onecut1 Nek2 Rb1 Cdkn2a Foxm1 Cdk1 Cks1b Tgfa Lama4 Xrcc1 Etv5 Cenpf Cenpa Cdc25b Ccnb2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Grk2 Prkce Rab5a Prkca Pld1 Plcb2 Gnai2 Gna15 Gna14 Pdpk1 Lyn Akt1 Fgr Pik3cg Hck Cbl Arrb2 Dnm1 Pik3r6 Plcb3 Cxcr1 Plcb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fgb Fga F10 Tgfbi Itgax F11r Icam4 Icam2 Itgam Itgal Fcgr3 Cd40lg Itgad Itgb2 Fgg Kng2 Plau Vcam1 C3 Thy1 Ccn1 Jam3 Plat Icam1 Plaur Spon2 Proc Gp1ba INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gm14226 Gys1 Stx4 Ppp1cc Ins2 Lnpep Rhoq Trip10 Ppp1r3a Vamp2 Prkci Insr Ywhah Ywhag Ywhae Ywhab Akt1 Sfn Akt2 Gsk3b Tbc1d4 Ywhaz Slc2a4 Stxbp4 Prkcz PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Stat5a Mapk10 Stat3 Stat1 Pik3r1 Eif2ak2 Ptprj Mapk8 Mapk1 Itgav Mapk3 Ksr1 Ptpn2 Brk1 Rhoa Arhgdia Bcar1 Map2k4 Rac1 Baiap2 Arpc1b Blk Actr2 Actr3 Ppp2r2b Arpc3 Arpc2 Itgb3 Pak1 Lyn Arpc5 Arpc4 Fgr Ppp2ca Hck Srf Ppp2r1a Pten Shc1 Src Rasa1 Grb10 Ptpn11 Nck1 Rap1a Gab1 Dok1 Sla Arap1 Rab4a Usp6nl Grb2 Prkca Tagln Myocd Sos1 Dock4 Crk Ptpn1 Actn4 Csk Hras Nherf2 Nherf1 Sipa1 Ywhah Ywhag Ywhae Ywhab Braf Sfn Elk1 Plcg1 Prkcd Ywhaz Mapk9 Jund Kras Jun Nras Fos Prkce Pla2g4a Vav2 Rab5a Fyn Yes1 Pin1 Wasl Myc Eps8 Pik3cg Pik3r6 Cbl Lrp1 Stat5b Iqgap1 Lck Dnm2 Afdn Raf1 Pdgfrb Pdgfb Abl1 Pag1 Arhgap35 Map2k2 Map2k1 Nck2 Sphk1 S1pr1 Rap1b Map2k7 Nckap1 Jak2 Pik3cb Pik3ca Wasf2 Cttn Rapgef1 Cyfip2 Rps6ka3 Abi1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 F11r Pip5k1c Nectin2 Afdn Pik3r1 Rap1a Vav2 Farp2 Ptk2 Itgav Pdgfrb Crk Pdgfb Rac1 Nectin1 Nectin3 Ptprm Cldn1 Itgb3 Rap1b Ctnnb1 Cdh1 Iqgap1 Pik3ca Ctnna1 Rapgef1 Src BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Nfkbia Jun Pik3r1 Fos Vav2 Mapk8 Mapk1 Nfatc1 Mapk3 Ets1 Rac1 Syk Map3k1 Lyn Chuk Inpp5d Akt1 Ptpn6 Map3k7 Mapk14 Pten Shc1 Rasa1 Traf6 Fcgr2b Dok1 Raf1 Ppp3ca Grb2 Map4k1 Sos1 Csk Hras Pag1 Cd72 Cd22 Malt1 Card11 Map2k1 Dapp1 Cd79a Pdpk1 Cd79b Ibtk Bcl10 Plcg2 Ptprc Blnk Nfkbib Ppp3cc Ppp3cb Elk1 Cd19 Bcl2a1d Sh3bp5 Ikbkb Ikbkg Camk2g Nfkb1 Pik3ca Btk Pou2f2 Rela REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Cdkn1b Arhgef15 Ngef Akap13 Mcf2 Arhgef11 Vav2 Arhgef28 Arhgdib Arhgef25 Arap1 Rhoa Arhgdia Vav3 Arhgap35 Arhgap5 Trio Ect2 Arhgef2 Abr Arap3 Def6 Srgap1 Vav1 Arhgef3 Bcr Ophn1 Arhgap9 Arhgef17 Arhgdig Arhgef10 Arhgef12 Myo9b Arhgef18 Plekhg6 Farp1 Arhgap6 Net1 Arhgap4 Arhgef10l Dlc1 Arhgap8 Arhgef1 Mcf2l EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Snap25 Syt1 Stx1a Stxbp1 Vamp2 Unc13b Chrna1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Mark2 Adam10 Neurl1a Notch4 Notch2 Notch3 Fbxw7 Dtx1 Dll1 Il4 Dll3 Dll4 Mycbp Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Dner Lnx1 Ctbp1 Cul1 Myc Skp1 Hdac1 Cbl EG433182 Gata3 Btrc Rab11a Ncor1 Ptcra Ep300 Skp2 Furin Adam12 Cdkn1a Spen Ncor2 Dnm1 Ccnd1 Maml1 Maml2 Numb Eps15 Itch Rbbp8 Kdm1a Rbpj Yy1 Notch1 Ncstn Aph1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Stat5a Lck Bcl2 Il2ra Ptpn11 Elf1 Pik3r1 Sp1 Il2 Il4 Ccnd3 Fasl Grb2 Sos1 Jak3 Cdk6 Jak1 Bcl2l1 Lta Myc Foxp3 Ccna2 Il2rg Stat5b Prf1 Ccnd2 Pik3ca Il2rb Shc1 Gab2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Jun Mapk10 Stat3 Nrg1 Nras Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk8 Mapk1 Grb2 Mapk3 Sos1 Hras Rac1 Erbb3 Nfatc4 Nf2 Chrne Usp8 Rnf41 Map2k2 Dock7 Map2k1 Akt1 Ppp3cb Bad Erbb2 Mtor Mapk9 Nrg2 Jak2 Pik3cb Pik3ca Kras Shc1 Src Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Vasp Gng2 Arrb1 Prkcg Prkcb Gnb1 Rab5a Prkca Elmo1 Plcb2 Gnai2 Pld2 Rab7 Gna15 Cxcr2 Gna14 Pdpk1 Rac2 Lyn Dock2 Akt1 Fgr Pik3cg Ppp2ca Hck Cbl Arrb2 Dnm1 Pik3r6 Ppp2r1a Plcb3 Rab11a Plcb1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc1 Sdc4 Sdc3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Fgb Fga Tgfbi F11r Kdr Sdc4 Itgav Lamb1 Vtn Pdgfrb Itga2b Vegfa Spp1 Pdgfb Tnc Fgg Fn1 Lamc1 Plau Itgb3 Col1a1 Col4a3 Sphk1 L1cam Col4a4 Thbs1 Pecam1 Thy1 Cd47 Edil3 Col4a1 Ibsp Fbn1 Col4a5 Col4a6 Ccn1 Col1a2 Sdc1 Plaur Lama4 Tgfbr2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Jun Stat5a Mapk11 Stat3 Il2ra Nras Stat1 Prkcb Pik3r1 Fos Prkce Il2 Ifng Mapk8 Mapkapk2 Mapk1 Socs1 Mapk3 Rhoa Jak3 Jak1 Syk Fyn Ptk2b Dok2 Myc Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Il2rb Shc1 Gab2 Rasa1 Irs1 Lck Bcl2 Irs2 Ptpn11 Raf1 Grb2 Sos1 Hras Cish Map2k2 Cdk2 Map2k1 Socs3 Mapk9 Pik3ca Kras GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc1 Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Npas2 Nr1d1 Nono Cry1 Cry2 Bhlhe40 Clock Bmal1 Chek1 Per2 Per1 Wdr5 Timeless Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Stat5a Il18r1 Il1b Stat3 Il2ra Stat1 Fos Il2 Il4 Ifng Fasl Socs1 Stat6 Atf2 Sphk2 Rab7 Mtor Mapk14 Il2rg Il2rb Nfkb2 Map2k3 Ccr5 Relb Gadd45g B2m Gzma Gadd45b Gzmb Lck Hlx Eomes Ccl4 Il1r1 Cd8a Cd8b1 Il12a Il12rb2 H2-Q10 Ripk2 Stat4 Il12b Il18 Il18rap Cd3e Cd4 H2-Eb1 Cd3g Map2k6 Nfkb1 Cd247 Jak2 Cd3d Il12rb1 Tyk2 Tbx21 Nos2 Rela BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plau Vcam1 Edil3 Itga4 Madcam1 Fbn1 Ccn1 Itgb8 Itgb6 Itgav Itgb7 Itgb5 Vtn Sdc1 Plaur Tgfbr1 Fn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Vtn Bcar1 Spp1 Rac1 Vav3 Ptk2b Itgb3 Akt1 Edil3 Cbl Col1a2 Fgf2 Tgfbr2 Hsp90aa1 Src Irs1 Pxn Tln1 Angptl3 F11r Mfge8 Adgra2 Ptpn11 Kdr Vcl Pi4kb Pi4ka Pik3c2a Csf1r Ptk2 Csf1 Vegfa Col11a1 Col11a2 Igf1 Fn1 Col2a1 Col3a1 Col1a1 Col6a1 Col5a2 Igf1r Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Rock1 Col6a3 Col4a6 Sdc1 Pik3ca Casp8 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Ep300 Hdac4 Tuba1b Mef2d Acss1 Acss2 Hoxa10 Kat2b Tubb2a H1-4 Trp53 Xrcc6 Crebbp Bax Sirt3 Sirt2 Sirt1 Sirt7 Cdkn1a Foxo4 Foxo3 Foxo1 Fhl2 Myod1 Ppargc1a RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rarg Ep300 Ncoa2 Ncoa1 Prkaca Prkcg Nrip1 Kat2b Mapk8 Mapk1 Mnat1 Vdr Ccnh Prkca Mapk3 Hdac3 Cdk7 Rbp1 Crebbp Hdac1 Ncor2 Akt1 Ncoa3 Rxrb Rxra Rxrg Mapk14 Cdk1 Rara Rarb HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Rack1 Eloc Arnt Hif1a Cops5 Trp53 Rbx1 Hif3a Cdkn2a Hif1an Os9 Egln2 Naa10 Egln3 Cul2 Hsp90aa1 Vhl FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Ep300 Jun Cdkn1b Cebpb Ar Nkx3-1 Shh Fos Sp1 Ins2 Col18a1 Pou2f1 Nrip1 Vtn Esr1 Brca1 Crebbp Ap1b1 Pisd Sftpd Cyp2c55 Nfia Nfic Serpina1d Scgb1a1 Dscam Nr2f2 Gcg Foxa1 Atp5pf Foxa2 Foxa3 Ncoa3 Xbp1 Ndufv3 Prdm15 Apob NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Mapk10 Ror2 Nlk Csnk1a1 Mapk8 Rhoa Nfatc2 Rac1 Pparg Tab2 Yes1 Tab1 Camk2a Setdb1 Daam1 Chd7 Flna Dvl1 Dvl2 Arrb2 Dvl3 Wnt5a Rock1 Mapk9 Map3k7 Cthrc1 Fzd2 Fzd5 Fzd7 Fzd6 Prkcz PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gng2 Mapk11 Nras Pik3r1 Gnb1 Gnai1 Gnai3 Grb2 Sos1 Rhoa Esr1 Bcar1 Hras Gnaz Nos3 Gnao1 Plcb2 Mmp2 Igf1 Gnai2 Mmp9 Gna11 Gna15 Gna14 Rock2 Gnaq Igf1r Gna13 Akt1 Strn Pelp1 Esr2 Hbegf Pik3ca Msn Plcb3 Kras Shc1 Plcb1 Src REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Cdx4 Jun Cdx1 Ctnnbip1 Klf4 Pitx2 Bcl9 mt-Co2 Myf5 Mitf Incenp Tcf4 Hbp1 Trrap Mmp2 Mmp9 Hdac2 Axin2 Ctbp1 Cul1 Myc Skp1 Hdac1 Ccn1 Id2 Ctnnb1 Cdh1 Cdkn2a Ccnd2 Btrc Tert Dkk1 Ep300 Lef1 Vcan Ar Ncoa2 Snai2 Apc Tcf7l2 Camk4 Ywhah Ywhag Ywhae Ywhab Neurog1 Sfn Cacna1g Myog Mdfic Dvl3 Ccnd1 Igf2bp1 Cby1 Fgf4 Zcchc12 Ywhaz Tbl1xr1 Kcnip4 Tnik Adcy7 Tle4 Ruvbl2 Med12 Tle2 Tle1 Krt1 Tle5 Dkk4 Chd8 Sall4 T Smarca4 Tcf7 Tcf7l1 Tbl1x Sp5 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Stat5a Bcl2 Irs2 Crkl Stat1 Ptpn11 Pik3r1 Rap1a Vav2 Gab1 Epor Mapk8 Sh2b3 Grb2 Tec Sos1 Epo Hras Bcl2l1 Lyn Socs3 Plcg2 Inpp5d Ptpn6 Cbl Plcg1 Mapk14 Nfkb1 Stat5b Jak2 Rapgef1 Btk Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Gadd45b Traf6 Mapk11 Map3k3 Ccm2 Map3k6 Map3k4 Taok1 Taok3 Map3k10 Traf2 Txn Rac1 Atm Tab2 Tab1 Map3k1 Map3k5 Map3k7 Mapk14 Map2k6 Gadd45a Camk2b Map2k3 Gadd45g C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Max Supt3 Myc Actl6a Ppp2ca Fbxw7 Taf9 Pml Gsk3b Kat5 Kat2a Supt7l Skp2 Ruvbl2 Ppp2r5a Hbp1 Cdkn2a Trrap Axin1 Zbtb17 Pin1 Ruvbl1 Taf12 Pak2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Kdr Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Pdgfrb Ptgs2 Vegfa Pdgfb Rac1 Gnaz Gnao1 Plcb2 Gnai2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Lyn Lama1 Nrg1 Tgfb1 Tgfb3 Fgr Hck App Prnp Slit2 Gpc1 Serpinc1 Flt1 Fgf2 Vegfa Fgfr1 Smad2 Tgfbr1 Blk Tgfbr2 Fyn Yes1 Src ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Jun Prkcg Prkcb Fos Pla2g4a Prkce Mapk8 Mapk1 Ednrb Ednra Mapk3 Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Plcb2 Edn2 Edn3 Prkch Ptk2b Cysltr2 Cysltr1 Akt1 Col1a2 Slc9a1 Mapk14 Slc9a3 Prkcq Src Edn1 Gnai1 Raf1 Gnai3 Prkca Crk Hras Gna12 Gnaz Gnao1 Gnai2 Map2k2 Gna11 Col3a1 Map2k1 Gna15 Gna14 Gnaq Prkcd Mmp1a Adcy7 Jak2 Plcb3 Plcb1 Trpc6 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Flt1 Pgf Vegfb Vegfa Kdr Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Jun Mapk10 Pik3r1 F2rl2 Nck1 Mapk8 Prkci Grb2 Map2k4 Rac1 Fyn Wasl Nck2 Nphs2 Nphs1 Akt1 Cd2ap Kirrel1 Arrb2 Bad Plcg1 Mapk9 Pard6a Pik3cb Pik3ca Tjp1 Prkcz Trpc6 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Nfkbia Jun Gng2 Pik3r1 Fos Gnb1 Prkce Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Mmp2 Pld2 Ptk2b Mmp9 Lyn Prkd1 Gna13 Akt1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Src Pxn Trip6 Gab1 Egfr Ptk2 Gnai1 Gnai3 Crk Hras Nherf2 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Plcg1 Gsk3b Prkcd Hbegf Adcy7 Tiam1 Nfkb1 Pik3cb Plcb3 Casp3 Arhgef1 Rela BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga7 Itga8 Itga5 Itga6 Itga9 Itga4 Itga1 Itga2 Col18a1 Itga10 Itga11 Itgav Itgb1 Vtn Spp1 Fgg Mdk Jam2 Cd81 Plau Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Fbn1 Npnt Col1a2 Nid1 Cspg4 Plaur Lama4 Fgb Fga Tgfbi Lamb2 Lama2 Lamb3 Lamb1 Lamc2 Vegfa Col11a1 Tnc Col11a2 Fn1 Tgm2 Col2a1 Lamc1 Col3a1 F13a1 Col1a1 Col6a1 Col5a2 Lama1 Lama3 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Itga3 Lama5 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fgb Fga Itga5 Itgam Elane Egfr Itgav Vtn Pdgfrb Itgb1 Crk Bcar1 Rac1 Itgb2 Fgg Mmp3 Dock1 Fn1 Mmp9 Plau Itgb3 Tgfb1 Hgf Lrp1 Ctsg Pdgfd Itga3 Fpr1 Itgb5 Klk4 Fpr2 Gpld1 Plaur Fpr-s1 Mmp12 Serpine1 Plg Ctrc Mmp13 Vldlr Src VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Lgals1 Cdkn1b Itga6 Spi1 Hdac3 Itgb1 Ptpa Itgb4 Myc Hdac1 Cdkn2b Foxo3 Wnt5a Creb1 Col1a2 Id2 Rbl1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Max Tmem126a Dkk1 Ep300 Sfrp1 Bcl2 Tbp Csde1 Tsc2 Hmgcs2 Cebpd Nfyb Nfya Cebpa Sp1 Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Mxd4 Pdgfrb Brca1 Smad2 Smad3 Ccl5 Smad4 Zbtb17 Cdkn1a Dntt Erbb2 Ccnd1 Ddit3 Cflar Gadd45a Irf8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg1 Erbb2 Erbb4 Egfr Ereg Hbegf Nrg2 Btc Areg Nrg4 Nrg3 Tgfa Erbb3 Egf Hsp90aa1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Gata1 Gng2 Gnb1 Grk2 Ranbp2 Hdac4 Tuba1b Ube2i Ran Tubb2a Hdac3 Ankra2 Hdac5 Esr1 Bcor Hdac7 Hdac6 Rfxank Hdac9 Mef2c Camk4 Ywhae Gata2 Ywhab Ncor2 Hdac11 Hdac10 Srf Bcl6 Hsp90aa1 Nr3c1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Wwp1 Fkbp1a Pml Xiap Eif2a Smurf1 Daxx Tgfb1 Tgfb3 Ppp2ca Arrb2 Ppp1ca Cav1 Ctnnb1 Map3k7 Ccn2 Pard6a Tgfbr1 Tgfbr2 Shc1 Grb2 Sos1 Dynlrb1 Nedd4l Tgfbrap1 Smad2 Zfyve16 Smad3 Ppp2cb Smurf2 Smad4 Tab2 Strap Tab1 Dab2 Dact2 Tgfbr3 Sptbn1 Ywhae Ppp2r2a Pdpk1 Rnf111 Camk2a Ppp1r15a Zfyve9 Smad7 Bambi Yap1 Itch Axin1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Jun Crkl Lcp2 Prkcb Dbnl Map3k8 Grap2 Mapk8 Map3k7 Map4k1 Crk Map2k4 Lat Map3k1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ep300 Chp1 Bcl2 Rcan2 Fkbp1a Prkaca Prkcg Prkcb Prkce Nr4a1 Mef2d Cabin1 Csnk1a1 Ran Mapk8 Akap5 Nfatc1 Prkca Mapk3 Nfatc3 Nfatc2 Crebbp Bax Prkch Camk4 Bcl2l1 Ywhah Map3k1 Ywhag Ywhae Ywhab Fkbp8 Map3k8 Sfn Nup214 Bad Gsk3b Prkcd Kpnb1 Ywhaz Mapk9 Mapk14 Pim1 Casp3 Prkcq Prkcz Rcan1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Inpp5d Akt1 Ptpn6 Cbl Vav1 Pten Itk Prkcq Shc1 Gab2 Lck Traf6 Lcp2 Ptpn11 Nck1 Rap1a Grap2 Grb2 Prkca Trpv6 Map4k1 Sos1 Csk Hras Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Flna Dbnl Map3k8 Sla2 Orai1 Stim1 Cd3e Plcg1 Stk39 Rassf5 Was Ikbkb Cd4 Fyb1 Sh3bp2 H2-Eb1 Ikbkg Cd3g Cd247 Cd3d Cd28 Cd86 Cd80 Kras VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Prkaca Prkcb Pik3r1 Nck1 Mapk1 Prkca Flt1 Mapk3 Shc2 Vegfa Nos3 Nrp1 Nrp2 Pdpk1 Pgf Vegfb Akt1 Cd2ap Cbl Hif1a Plcg1 Cav1 Pik3ca Hsp90aa1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Grb2 Ednra Sos1 Edn1 Hras Egf Mtor Egfr Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gng2 Lgals3 Gli2 Prkaca Shh Gnb1 Smo Ptch1 Pias1 Csnk1a1 Gnai1 Csnk1g3 Csnk1g1 Gnai3 Csnk1g2 Rbbp4 Rbbp7 Crebbp Sin3a Sin3b Gnaz Gnao1 Gnai2 Csnk1d Csnk1e Hdac2 Map2k1 Foxa2 Hdac1 Akt1 Arrb2 Fbxw11 Gsk3b Sap30 Prkcd Rab23 Gli1 Gli3 Mtss1 Sap18b Ift88 Kif3a Stk36 Ift172 Btrc Sufu Spop INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Exoc1 Exoc2 Grb10 Ptpn11 Pik3r1 F2rl2 Eif4ebp1 Exoc7 Nck1 Ins2 Rhoq Trip10 Dok1 Prkci Sh2b2 Insr Grb2 Sos1 Ptpn1 Crk Hras Sgk1 Ptpra Pdpk1 Nck2 Inpp5d Akt1 Cbl Foxo3 Akt2 Cav1 Grb14 Pard6a Pik3ca Exoc3 Sorbs1 Exoc4 Rapgef1 Shc1 Prkcz Exoc5 Exoc6 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfd Pdgfrb Pdgfb Pdgfc Pdgfra EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Efna1 Pak1 Inppl1 Pik3r1 Epha2 Vav2 Cbl Ptk2 Grb2 Tiam1 Rhoa Bcar1 Rac1 Pik3ca Vav3 Arhgap35 Acp1 Shc1 Src ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Stat3 Stat1 Pik3r1 Mapk8 Mapk1 Sh2d2a Mapk3 Ksr1 Brk1 Map2k4 Rac1 Baiap2 Arpc1b Actr2 Pld1 Actr3 Pld2 Map3k1 Arpc3 Arpc2 Arpc5 Arpc4 Ppp2ca Srf Slc9a1 Smad1 Ppp2r1a Src F2rl2 Gab1 Capn2 Usp6nl Grb2 Prkca Sos1 Hras Ywhah Ywhag Ppp2r2a Ywhae Pdpk1 Ywhab Braf Sfn Elk1 Egr1 Bad Prkcd Ywhaz Mapk9 Dusp1 Kras Mapk7 Prkcz Zfp36 Map3k2 Jun Mylpf Ralgds Arf4 Ppp5c Nras Diaph3 Map2k5 Fos Dusp6 Vav2 Rab5a Rin1 Pebp1 Rps6ka4 Rps6ka5 Atf2 Bcl2l1 Wasl Akt1 Eps8 Mtor Creb1 Iqgap1 Rala Egfr Raf1 Mef2c Egf Map2k2 Map2k1 Rictor Mapkap1 Mlst8 Nckap1 Pik3cb Pik3ca Wasf2 Cyfip2 Rps6ka3 Abi1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Ywhae Ppp2r5d Clip1 Katna1 Lrpap1 Pafah1b3 Pafah1b2 Pafah1b1 Cdk5r2 Dab1 Cdk5 Dync1h1 Cdk5r1 Ndel1 Reln Dcx Rhoa Pla2g7 Iqgap1 Rac1 Abl1 Nudc Vldlr Map1b SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Ccne1 Cdkn1a Egr1 Tuba1b Itga1 Ccna2 Rock1 Mapk1 Mapk3 Rhoa Agt Itgb1 Ptp4a3 Rhoc Bcar1 Ptp4a2 Rabggta Rac1 Rabggtb Atf5 Cdk2 Src EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Ptpn13 Pik3r1 Mapk8 Itga2b Map2k4 Rac1 Blk Rgs3 Fyn Yes1 Ephb1 Ephb2 Itgb3 Ephb4 Nck2 Lyn Efnb1 Efnb2 Fgr Hck Dnm1 Map3k7 Tiam1 Pik3ca Src VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk11 Itga5 Pik3r1 Itga4 Itga1 Itga2 Mapk1 Grb2 Mapk3 Sos1 Itgb1 Crk Map2k4 Vegfd Fn1 Vegfc Flt4 Col1a1 Akt1 Creb1 Col1a2 Mapk14 Rps6ka1 Pik3ca Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Efna1 Pxn Arrb1 Git1 Epha2 Nck1 Egfr Arf6 Itga2b Gulp1 Egf Fbxo8 Cyth2 Ipcef1 Acap2 Gna11 Cyth3 Kif13b Lhcgr Gna15 Itgb3 Iqsec1 Gna14 Arap2 Gnaq Adap1 Hgf Arrb2 Tshr Agtr1a Met Adrb2 Acap1 Src P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Gata1 Mapk11 Trp63 Mdm2 Pml Jag2 Plk3 Bax Jak1 Pin1 Sirt1 Casp2 Prkacb Pfdn5 Fbxo45 Myc Tuba1a Bub1 Ccne2 Pea15 Il1rap Clca2 Ndufs2 Plk1 Hagh Foxo3 Gramd4 Aen Dcp1b Trp73 Rnf43 Mapk14 Dedd Flot2 Afp Hsf1 Wt1 Bak1 Cdk1 Bub3 Il4ra Serpine1 Ube4b Nsg1 Gdf15 Plpp1 Ep300 Bin1 Sp1 Rad51 Bcl2l11 Nedd4l Chek1 Abl1 Cdk6 Cdk2 Ada Serpina1d Ntrk1 Rack1 Cdkn1a Sfn Wwox Ccna2 Brca2 Kat5 Hey2 Yap1 Rb1 Itch Rchy1 Fasn Rela Fas CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Gng2 Mapk11 Arrb1 Nras Pik3r1 Gnb1 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Gnaz Gnao1 Gnai2 Map2k2 Map2k1 Pdpk1 Akt1 Rictor Dnm1 Mtor Ccl11 Mapk14 Cxcl9 Mapkap1 Map2k6 Mlst8 Pik3cb Pik3ca Cxcl11 Map2k3 Cxcl10 Cxcr3 Kras Pf4 Src Cxcl13 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Il3ra Cnksr1 Stat5a Srp9 Cebpb Ptpn11 Prkaca Pik3r1 Grb2 Csf2rb2 Cish Bcl2l1 Ywhag Prkacb Hdac1 Inpp5d Id1 Ywhaz Pim1 Stat5b Jak2 Pik3ca Osm Shc1 Gab2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Grk3 Gng2 Mapk11 Prkaca Prkcg Prkcb Gnb1 Prkce Grk2 Rhoa Rac1 Blk Plcb2 Syk Fyn Yes1 Prkch Lyn Vcam1 Gna13 Akt1 Fgr Hck Pik3cg Pik3r6 Arrb2 Arr3 Mapk14 Icam1 Gnb5 Rab11a Prkcq Src Lck Ptgdr Ptgir Prkg1 Tbxa2r Egfr Prkca Nherf1 Gna12 Nos3 Egf Gnai2 Tgm2 Gna11 Gna15 Gna14 Gnaq Dnm1 Rock1 Prkcd Sele Arhgef1 Prkcz A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Col17a1 Itga6 Pik3r1 Cd9 Il1a Pmp22 Egfr Lamb2 Lama2 Grb2 Lamb3 Prkca Lamb1 Itgb1 Lamc2 Hras Mst1 Itgb4 Rac1 Erbb3 Casp7 Egf Ywhah Lamc1 Ywhag Ywhae Ywhab Lama1 Lama3 Akt1 Sfn Erbb2 Rxrb Rxra Rxrg Ywhaz Cdh1 Lama5 Met Mst1r Pik3ca Lama4 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Nras Eif4ebp1 Clip1 Srebf1 Pml Mapk1 Eif4e Mapk3 Pld1 Pld2 Akt1 Mtor Fbxw11 Btrc Eif4a1 Ccne1 Irs1 Tsc2 Prr5 Rraga Ddit4 Rragb Rragc Rragd Raf1 Tsc1 Eif4b Ulk1 Ulk2 Prkca Rb1cc1 Poldip3 Pdcd4 Hras Atg13 Eef2 Sgk1 Map2k2 Cdk2 Ywhah Ywhag Map2k1 Ywhae Pdpk1 Ywhab Braf Sfn Rictor Rptor Ikbkb Ywhaz Mapkap1 Rps6ka1 Mlst8 Deptor Akt1s1 Eef2k Yy1 Kras Ppargc1a ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Chuk Nfkb1 Map3k14 Btrc Nfkb2 Relb DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Tigar Cebpz Nlrc4 E2f2 Prdm1 Prkab1 Ctsd Ppm1j Trp63 Mdm2 Col18a1 Pml Plk3 Mcl1 Spp1 Bax Pou4f1 Trrap Edn2 Pou4f2 Mmp2 Cd82 Taf9 Cav1 Hspa1a Tgfa Pten E2f3 Tsc2 Nfyb Nfya Nfyc Pcna Snai2 Ndrg1 Apc Trp53 Sfn Hgf Bcl2a1d Serpinb5 Carm1 Bdkrb2 Met Gadd45a Igfbp3 Dusp5 Rchy1 Dusp1 Jun Epha2 Perp Cse1l Apaf1 Ccng1 Pidd1 Cop1 Bcl2l1 Hdac2 Casp1 Foxa1 Tfdp1 Trp73 Lif Afp Bcl6 Bak1 Serpine1 Gdf15 Atf3 Dkk1 Ep300 Bcl2 E2f1 Vcan Sp1 Ddit4 Egfr Kat2a Vdr Casp6 Crebbp Drosha Ccnk Pcbp4 Tap1 Hic1 Ppp1r13b Msh2 Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Map4k4 Cdkn1a Rgcc Steap3 Jmy Fdxr Ddx5 Trp53bp2 Btg2 Rrm2b Ddb2 Prmt1 Bcl2l14 Rps27l Gpx1 Bcl2l2 Bnip3l Rnf144b Trp53inp1 Triap1 Irf5 Rb1 Aifm2 Dgcr8 Htt Bid Scn3b Zfp385a Arid3a Smarca4 Pms2 Cx3cl1 Pycard Fas Mlh1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkaca Prkce Lpar4 Creb1 Adcy3 Adcy7 Adcy4 Rps6ka5 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Adcy9 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Nme1 Snx1 Adam10 Dnm2 Bdnf Gdnf Slit1 Gfra1 Cbll1 Dsp Ctnnd1 Rab5a Cables1 Mep1b Igf2 Egfr Arf6 Cdh2 Robo1 Zbtb33 Hgs Ptpn1 Hras Crebbp Rac1 Abl1 Mmp3 Gna12 Fyn Egf Ntrk2 Rab7 Mmp7 Igf1r Gna13 Ptpn6 Ctnnb1 Cdh1 Tiam1 Rin2 Iqgap1 Met Jup Ret Casp3 Ctnna1 Src AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Ppp2r5d Git1 Birc5 Prkaca Mdm2 Ran Aurkaip1 Tacc1 Oaz1 Aurkb Cpeb1 Trp53 Ndel1 Ajuba Dlgap5 Tdrd7 Brca1 Fzr1 Pak1 Akt1 Tacc3 Gsk3b Tpx2 Ckap5 Gadd45a Aurka Arhgef7 Cenpa Cdc25b CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Jun Cblb Stat5a Mapk10 Traf6 Mapk11 Pik3r1 Il4 Mapk8 Cd40lg Traf2 Fcamr Traf3 Cd40 Map2k4 Tdp2 Jak3 Tnfaip3 Bcl2l1 Map3k1 Myc Map3k14 Akt1 Pik3cg Pik3r6 Birc3 Mapk9 Birc2 Mapk14 Nfkb1 Pik3cb Pik3ca Traf1 Rela VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network C3 Ncoa2 Ncoa1 Nr0b1 Ncoa3 Esr2 Smarce1 Ube2m Uba3 Nedd8 Smarcb1 Ddx54 Zfp709 Smarca4 Nr0b2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Ezr Mark2 Tsc2 Ctsd Prkaca Tsc1 Trp53 Esr1 Stk11ip Smad4 Stk26 Mark4 Crtc2 Ywhah Stradb Ywhag Smarcd3 Ywhae Strada Cab39 Etv4 Myc Ywhab Stk11 Sik3 Sik2 Sik1 Sfn Psen2 Brsk2 Brsk1 Mtor Creb1 Gsk3b Rptor Cdc37 Ywhaz Mlst8 Akt1s1 Hsp90aa1 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb2 Ephb3 Ephb4 Efnb1 Efnb2 Ephb1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map3k2 Nras Map2k5 Fos Rap1a Cdk5 Raf1 Mapkapk2 Mapk1 Cdk5r1 Mapk3 Ntf3 Rps6ka5 Hras Rit1 Mef2c Rit2 Ehd4 Map2k1 Trpv1 Braf Rap1b Elk1 Egr1 Creb1 Srf Prkcd Mapk14 Map2k6 Rps6ka1 Map2k3 Kras Mapk7 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map3k3 Stat1 Nsmaf Madd Tnfrsf1a Sqstm1 Bag4 Tradd Prkci Traf2 Txn Tnfaip3 Tab2 Smpd2 Tab1 Map3k1 Map4k4 Rack1 Chuk Nrk Map3k5 Map4k5 Tnf Map4k3 Cav1 Birc3 Adam17 Tnfrsf1b Ikbkb Cyld Birc2 Map3k7 Map4k2 Ikbkg Rffl Map2k7 Tnik Nfkb1 Casp8 Smpd1 Map2k3 Traf1 Ripk1 Prkcz Rela Fadd FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Cpt1a Bdh1 Foxf1 Cebpb Abcc8 Kcnj11 Alb Cebpd Apoa1 Hnf1a Cebpa Sp1 Cpt1b Ins2 Cpt1c Hadh Dlk1 G6pc1 Hnf4a Foxa1 Foxa2 Foxa3 Akt1 Creb1 Pklr Tat Afp Aldob Nkx2-1 Acadvl F2 Alas1 Tfrc Ttr Igfbp1 Ucp2 Slc2a2 Nf1 Pck1 Pdx1 Nr3c1 Acadm Gck CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Jun Rasgrf1 Diaph3 Pik3r1 Prkce Vav2 Mapk8 Mapk1 Mapk3 Arhgdia Bcar1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Pld1 Actr3 Yes1 Pak2 Map3k1 Arpc3 Wasl Arpc2 Pak1 Arpc5 Arpc4 Map3k11 Eps8 Cbl Mtor Ctnnb1 Mapk14 Cdh1 Pard6a Iqgap1 Cfl1 Map2k3 Myl2 Ctnna1 Limk1 Arhgef7 Limk2 Src Arhgef6 F2rl2 Exoc7 Cdc42bpa Septin2 Pax6 Raf1 Hes5 Tnk2 Apc Hras Braf Gsk3b Mapk9 Map2k7 Map2k6 Tiam1 Pak4 Pik3ca Dlg1 Prkcz CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Stat5a Gng2 Stat3 Stat1 Pik3r1 Gnb1 Cxcl12 Grk2 Hgs Rhoa Bcar1 Rac1 Blk Plcb2 Fyn Yes1 Ptk2b Mmp9 Pak1 Lyn Inpp5d Gna13 Akt1 Ptpn6 Fgr Hck Pik3cg Pik3r6 Arrb2 Mtor Foxo1 Vav1 Arr3 Stat5b Cfl1 Limk1 Src Lck Pxn Ptpn11 Cxcr4 Ptk2 Gnai1 Gnai3 Rgs1 Ubqln1 Vps4a Vps4b Crk Grk6 Stat2 Rhoc Ralb Csk Rhob Pag1 Gnaz Gnao1 Gnai2 Pdpk1 Rack1 Ptprc Rap1b Rictor Dnm1 Bad Cd3e Cd4 H2-Eb1 Ssh1 Mapkap1 Mlst8 Cd3g Cd247 Jak2 Cd3d Pik3cb Itch Pik3ca Plcb3 Plcb1 Prkcz P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Ywhag Ywhae Tcf3 Mapk11 Ywhab Tsc2 Sfn Hspb1 Creb1 Mapkapk3 Srf Raf1 Mapkapk2 Ywhaz Mapk14 Etv1 Lsp1 Cdc25b Ywhah Th PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Jun Dkk1 Ppp2r5d Adam10 Psen1 Ppard Nlk Fos Hnf1a Dtx1 Dll1 Csnk1a1 Wnt1 Apc Mapk1 Mapk3 Crebbp Nkd1 Dkk2 Frat1 Tab1 Ctbp1 Myc Hdac1 Dvl1 Lrp6 Ccnd1 Wif1 Fbxw11 Gsk3b Ctnnb1 Map3k7 Fzd1 Tle1 Kremen2 Tle5 Btrc Rbpj Axin1 Ncstn Notch1 Aph1b VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Ep300 Wwp1 Mfge8 Shh Sp1 Cables1 Perp Trp63 Mdm2 Pml Jag1 Vdr Itgb4 Hbp1 Abl1 Bax Dhrs3 Traf4 Ogg1 Spata18 Tfap2c Ada Nqo1 Smarcd3 Evpl Ssrp1 Dicer1 Cdkn1a Chuk Fdxr Clca2 Plk1 Serpinb5 Aen Prkcd Ikbkb Egr2 Flot2 Itga3 Cdkn2a Gadd45a Igfbp3 Itch Btrc Gdf15 Fas IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ep300 Cebpb Il1b Crkl Stat3 Stat1 Ptpn11 Pik3r1 Rap1a Pias1 Ifng Mapk1 Socs1 Ptpn2 Mapk3 Ifngr1 Crebbp Jak1 Map3k1 Pias4 Casp1 Map2k1 Dapk1 Camk2a Ptges2 Irf9 Smad7 Akt1 Map3k11 Rap1b Cbl Camk2d Mtor Prkcd Camk2g Jak2 Pik3ca Camk2b Irf1 Rapgef1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Pip5k1a Ap2m1 Gbf1 Uso1 Gga3 Kdelr1 Asap1 Ap2a1 Arfip2 Gosr2 Cltb Copa Arfgap1 Cd4 Clta Rac1 Arf1 Cyth2 Pld2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Jun Myd88 Traf6 Il1b Il1r1 Map3k3 Irak4 Pik3r1 Il1a Sqstm1 Mapk8 Prkci Tab2 Tab1 Casp1 Chuk Il1rap Ikbkb Ube2v1 Map3k7 Ticam2 Ikbkg Irak3 Erc1 Map2k6 Tollip Nfkb1 Il1r2 Il1rn Ube2n Pik3ca Prkcz Irak1 Rela GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Pbx1 Jun Krt14 Stat5a Smarcc2 Mapk10 Mapk11 Pomc Ppp5c Krt5 Stat1 Prkaca Fos Nr4a1 Il2 Il4 Mdm2 Pou2f1 Ifng Cdk5 Mapk8 Mapk1 Cdk5r1 Nfatc1 Spi1 Csf2 Mapk3 Fgg Bax Hdac2 Prkacb Hdac1 Akt1 Creb1 Mapk14 Afp Stat5b Icam1 Gata3 Hsp90aa1 Nr3c1 Ep300 Tbp Ncoa2 Ncoa1 Il5 Prl Csn2 Trp53 Crebbp Sgk1 Ywhah Cdkn1a Sfn Egr1 Gsk3b Il6 Mapk9 Il13 Mmp1a Nfkb1 Nr1i3 Tsg101 Smarcc1 Kmt5b Sele Fkbp5 Tbx21 Vipr1 Pou1f1 Irf1 Smarca4 Smarcd1 Fkbp4 Cga Rela Pck2 Krt17 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Cblb Stambp Sh3gl2 Amph Chmp3 Epn1 Nras Pik3r1 Zfyve28 Rab5a Ptk2 Egfr Raf1 Grb2 Hgs Sos1 Ube2d3 Hras Ube2d1 Spry2 Egf Usp8 Synj1 Cbl Dnm1 Itsn1 Lrig1 Sh3kbp1 Eps15 Tsg101 Pik3cb Pik3ca Kras Arhgef7 Shc1 Src E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdkn1b E2f2 Uxt Ces1d Tfdp2 Cdkn2c Cbx5 Tyms Mybl2 Sult2a1 Ccnd3 Ranbp1 Mcm3 Ces2h Ces4a Prmt5 Pola1 Apaf1 Dhfr Rybp Orc1 Mcl1 Ces3b Hbp1 Rrm1 Ces5a Rrm2 E2f6 Trrap Casp7 E2f7 Wasf1 Sirt1 Cdc6 Plau Myc Hdac1 Ccne2 Cdc25a Tfdp1 Trp73 Tfe3 Rbl1 Cdkn2a Cdk1 Serpine1 Xrcc1 E2f3 Tk1 Ccne1 Smarca2 Ep300 E2f1 Trim28 Cebpa Sp1 Kat2b Kat2a Rbbp4 Topbp1 Brca1 Crebbp Atm Rbl2 Hic1 Cdk2 E2f4 Cdkn1a E2f5 Ccna2 Rb1 Rbbp8 Yy1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Ripk2 Traf6 Chuk Bcl10 Tnf Tnfrsf1a Ran Ikbkb Cyld Birc2 Ikbkg Erc1 Prkca Nfkb1 Ube2d3 Atm Btrc Tnfaip3 Nod2 Rela Malt1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Akt1 Ptpn6 Cbl Vav1 Prkcq Shc1 B2m Lck Traf6 Lcp2 Cd8a Cd8b1 Rap1a Grap2 Grb2 Prkca Trpv6 Sos1 Csk Hras H2-Q10 Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Map3k8 Orai1 Stim1 Cd3e Plcg1 Rassf5 Ikbkb Ikbkg Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Kras REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Jun Cdkn1b Ube3a Fos Il2 Ifng Mapk1 Smg5 Mapk3 Sin3a Sin3b Terf1 Smg6 Hdac2 Tinf2 Parp2 Tnks Dkc1 Pot1 Myc Pif1 Hdac1 Wrn Tgfb1 Acd Akt1 Znfx1 Terf2ip Hnrnpc Pinx1 Mtor Sap30 Mxd1 Sap18b Terf2 Wt1 Hsp90aa1 Tert Max Ifnar2 E2f1 Mre11a Nbn Sp1 Sp3 Egfr Rad50 Rbbp4 Rbbp7 Xrcc6 Esr1 Xrcc5 Blm Atm Abl1 Rad9a Smad3 Egf Ywhae Nr2f2 Hus1 Ccnd1 Rad1 Nfkb1 Irf1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Jun Cdkn1b Mapk11 E2f2 Mitf Mdm2 Ccnd3 Spi1 Csf2 Hdac3 Atf2 Smarcb1 Pparg Sirt1 Ctbp1 Hdac1 Ppp2ca Tfdp1 Suv39h1 Brd2 Pax3 Aatf Rbp2 Atf7 Mapk14 Ckm Dnmt1 Taf1 Cdkn2a Ccnd2 Ubtf E2f3 Myod1 Ccne1 Ep300 Tbp Cebpb E2f1 Elf1 Cebpd Cebpa Gsc Runx2 Raf1 Cbx4 Rbbp4 Skp2 Crebbp Abl1 Cdk6 Mef2c Sftpd Cdk4 Cdk2 E2f4 Cdkn1a Ccna2 Ccnd1 Mapk9 Met Rb1 Tgfb2 Smarca4 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Pias4 Ctdsp1 Nup214 Ube2i Kpnb1 Mapk1 Mapk3 Ppm1a Nup153 Ctdspl Smad2 Tgfbrap1 Smad3 Smad4 Map3k1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Jun Fos Cxcl12 Npm1 Ets1 Hdac7 Mcl1 Itgb2 Hnf4a Gata2 Tff3 Akt1 Ldha Hmox1 Creb1 Id2 EG433182 Plin2 Tfrc Adm Serpine1 Cp Igfbp1 Pfkfb3 Eng Nt5e Car9 Pgm1 Fech Pkm Gck Tert Aldoa Ep300 Abcb1a Pfkl Rora Hk2 Edn1 Ncoa2 Hk1 Ncoa1 Bhlhe41 Sp1 Cxcr4 Ndrg1 Cops5 Epo Bhlhe40 Vegfa Crebbp Furin Egln3 Smad3 Lep Cited2 Smad4 Pgk1 Slc2a1 Abcg2 Tf Arnt Hif1a Nos2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Crkl Pik3r1 Grin2a Mapk8ip1 Rap1a Lrpap1 Pafah1b1 Dab1 Cdk5 Mapk8 Cdk5r1 Reln Itgb1 Fyn Map1b Nck2 Arhgef2 Akt1 Map3k11 Cbl Gsk3b Map2k7 Itga3 Grin2b Pik3ca Vldlr Rapgef1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Chuk Pik3r1 Dap3 Tnfsf10 Ikbkb Mapk8 Tradd Mapk1 Ikbkg Traf2 Mapk3 Cflar Map2k4 Pik3cb Pik3ca Casp8 Smpd1 Ripk1 Map3k1 Fadd RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk14 Gng2 Mapk11 Gnb1 Crh Mapk8 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Stat5a Stat3 Stat1 Pik3r1 Kdr Eif2ak2 Ins2 Csf1r Itga1 Gab1 Lman1 Pias1 Egfr Rab4a Csf1 Insr Grb2 Stat6 Ptpn2 Sos1 Ptpn1 Pdgfrb Itgb1 Eif2a Vegfa Crebbp Pdgfb Jak3 Jak1 Egf Hgf Kpnb1 Stat5b Met Pik3cb Pik3ca Shc1 Src BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Ctdsp1 Grem1 Ahsg Sostdc1 Mapk1 Rgmb Xiap Rgma Hjv Chrd Cer1 Bmp4 Fst Nog Bmpr1a Ski Bmp6 Zfyve16 Bmp2 Smad6 Smad4 Smurf2 Tab2 Tab1 Smurf1 Ppp1r15a Smad7 Bambi Nup214 Ppp1ca Gsk3b Bmpr2 Map3k7 Smad1 Smad9 Ppm1a Bmp7 Ctdspl Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna15 Gna14 Gng2 Rock2 Gnaq Gna13 F2rl2 Gnb1 Rock1 Rhoa F2 Plcb2 F2rl3 Myl2 Gna11 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga Appl1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Med23 Med12 Med1 Dhh Hhip Ihh Stk36 Prkaca Ctnnb1 Gli1 Med6 Gli2 Cdk8 Ywhae Grk2 Ptch2 Sap18b Ptch1 Dyrk1a Sufu Boc Arrb2 Gas1 Kif27 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Creb1 Ar Hdac1 Hspb1 Akt1 Pik3r1 Ptk2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Runx2 Rb1 Kat2b Tgfbr3 Prkar2a Trim33 Pml Ski Map2k3 Samd3 Mef2a Mef2c Brca1 Zfyve9 E2f4 Cdkn1a Tgfbr2 Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Ube2i Myc Sox9 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d1 Nup153 Trp73 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Pik3ca Ccnd1 Vdr Trp53 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Nup214 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Tab1 Junb Daxx Smad6 Hnf4a Ing2 Xpo1 Xpo4 Pdpk1 Ctcf Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Eng Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Prkar1b Nfyc Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Fosb Runx3 Cd44 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Pag1 Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Shb Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Pgam1 Jak3 Ptprh Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Card11 Bdh1 Ldha Ldhb Tuba4a Prpf4b Icos Zdhhc17 Golga5 Ctla4 Was Cd3g Actr10 Cd3e Cd3d Dusp3 Def6 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Elp3 Mpzl1 Map2k1 Rapgef1 Hnrnph3 Nedd9 Stat1 Dbnl Mapk7 Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Erbin Cd86 Sdcbp Cd84 Sh2d2a Cd82 Cd80 Snrnp70 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Fcrl5 Stk39 Pkp4 Flnb Anxa2 Raf1 Inpp5d Shc1 Pi4ka Stk4 Acly Ripk2 Elmo1 Abl1 Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Txnrd1 Pecam1 Nfatc1 Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Ddx49 Pkm Lck Evl Sos2 Lcp2 Sos1 Lpxn Ywhaz Eif3m Ubash3b Atp1a1 Src Atp1a3 Ptpn6 Trim25 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh2b3 Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Runx2 Esr1 Akt1 Src Ptk2 Jak3 Mapk1 Shc1 Plcg1 Plcg2 Khdrbs1 Chuk Crp Erbb2 Irs1 Irs4 Eif4ebp1 Pde3a Socs7 Gsk3b Prkaa1 Prkaa2 Gnaq Slc2a4 Fyn Jak1 Nos3 Cfl2 Sh2b1 Egfr Eif4e Stat1 Gsk3a Cdk5 Itgb5 Mapk8 Lep Nfkbia Limk1 Prkce Rps6ka2 Acacb Ncoa1 Igf1r Grb2 Ikbkb KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Matk Socs6 Ptpru Gys1 Akt1 Jak2 Sh3kbp1 Pik3r1 Mad2l1 Atf2 Rela Fgr Hck Prkcb Rps6ka1 Mapk1 Kit Tnfrsf10b Prkca Il7r Spred1 Ezr Raf1 Spred2 Inpp5d Grb7 Ep300 Mtor Crkl Epor Csf2rb2 Mapk12 Yes1 Cblb Abl1 Kitlg Rdx Msn Wipf1 Stat5a Stat5b Fes Cdk2 Hras Rasa1 Grap Jun Pik3ca Sos1 Cltc Src Jak3 Ptpn11 Mapk14 Tec Was Eif4ebp1 Gsk3b Crk Fyn Stat1 Mapk8 Socs1 Mitf Socs5 Socs4 BCR%NETPATH%BCR BCR Rb1 Hck Prkcb Rps6ka1 Prkd1 Crkl Plcg1 Prkcd Cdk2 Cd72 Stap1 Elk1 Sla2 Rasa1 Chst15 Malt1 Prkcq Gtf2i Tcl1 Rasgrp3 Btk Bcl10 Pip4k2b Pip4k2c Pip4k2a Cd79a Lyn Cd79b Pik3cg Cdk7 Bcl6 Btla Hnrnpk Itpr2 Bank1 Nfatc3 Cd22 Plekha2 Plekha1 Grb2 Hcls1 Lat2 Ikbkb Blnk Itk Ptpn18 Ccl4 Casp7 Mapkapk2 Casp9 Sh2b2 Fcgr2b Bax Stat3 Pip5k1c Pip5k1b Pip5k1a Vav1 Card11 Rapgef1 Ctnnb1 Nedd9 Stat1 Creb1 Akt1 Ptk2 Atf2 Rela Dok1 Mapk1 Shc1 Itpr1 Zap70 Nck1 Nfatc2 Jun Lck Sos2 Sos1 Map4k1 Ptpn6 Junb Mapk14 Pdpk1 Sh3bp2 Tec Foxo3 Chuk Fos Eif4ebp1 Gsk3b Crk Fyn Pik3r2 Gsk3a Bcar1 Fosb TNFALPHA%NETPATH%TNFALPHA TNFalpha Prkca Ep300 Stat5a Gtf2i Casp7 Mapkapk2 Bax Nkiras1 Rpl4 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tbk1 Tnfrsf11a Dpf2 Kcnq1 Tax1bp1 Polr1b Polr1c Txnip Polr1a Polr1d Polr1e Actl6a Smarce1 Tifa Cdc37 Cdc34 Rffl Rasa3 Akt2 Nfkbiz Txn Glg1 Sec16a Cradd Dcaf7 Nfkbie Diablo Rel Faf1 Ikbkg Tnfrsf8 Ikbke Mark2 Tnfrsf1b Rfk Akap8 Psmb5 Ywhae Gab1 Bcl2l1 Rack1 Fkbp5 Fbxw7 Fadd Smpd3 Psmc2 Psmc1 Psmc3 Map2k5 Creb1 Itch Bid Hdac1 Commd1 Hspb1 Akt1 Trpc4ap Psmd7 Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Elp1 Psmd1 Mapk1 Ktn1 Pkn1 Map3k11 Lrpprc Mapk9 Brinp1 Mapk3 Nr2c2 Nlrp4e Ube2i Tnf Map3k5 Skp1 Hsp90aa1 Pdk1 Fbl Ppp1r12a Unc5cl Ppp1r13l Usp2 Xiap Fbxw11 Txlna Ube2d3 Tank Relb Map3k3 Map3k2 Btrc Rxra Flna Papola Bag4 Ripk3 G3bp2 Cops3 Kpna6 Kpna3 Cdk9 Zbtb17 Cyba Ccnt1 Trap1 Bcl3 Tab3 Tab2 Traf7 Mcm7 Traf4 Pfdn2 Traf6 Traf5 Birc3 Jun Birc2 Ywhah Ywhag Psmd12 Copb2 Hdac2 Cav1 Smarcb1 Ywhab Psmd13 Alpl Rasal2 Rnf11 Hdac6 Iqgap2 Peg3 Bcl7a Ppp6c Nupr1 Rps6ka5 Mcm5 Smarca4 Cul1 Tnip2 Polr2h Tab1 Pdcd2 Junb Nsmaf Zfand5 Cflar Casp3 Romo1 Casp2 Trim32 Spag9 Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Foxo1 Mtif2 Map2k6 Rb1 Pml Nfkbia Crebbp Grb2 Nfkb1 Pak1 Stat1 Mapk8 Map3k8 Hsp90ab1 Dok1 Ddx3x Sos2 Sos1 Ywhaz Src Ptpn11 Mapk14 Irs1 Egfr ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Lamc1 Ar Lamc2 Vim Akt1 Pik3r1 Ptk2 Mapk1 Prkca Mapk3 Shc1 Mtor Yes1 Abl1 Prkcd Trp73 Pik3cg Jun Ywhah Pik3ca Grb2 Ywhab Ywhaz Src Ptpn11 Mapk14 Casp3 Clca1 Erbb2 Rpsa Irs1 Irs2 Fos Rhoa Pak1 Rac1 Eif4ebp1 Plec Dsp Lama5 Cd151 Itgb4 Lama2 Lama3 Fyn Mst1r Pik3r2 Met Mylk3 Pik3r3 Egfr Col17a1 Eif4e Itga6 Ntn1 Ephb2 Ywhae Lamb2 Gab1 Lamb3 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Erbin Smad2 Smad3 Eif6 WNT%NETPATH%WNT Wnt Map3k7 Sox1 Akt1 Ctbp1 Wnt5a Cdh1 Setdb1 Pi4k2a Prkcb Ppp1ca Sfrp2 Ppp2ca Sfrp1 Prkca Daam1 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Yes1 Lrp1 Arhgef4 Csnk1a1 Nlk Prkcd Lrp5 Gpc3 Dvl3 Wnt2 Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Smad1 Bcl9 Pin1 Tcf4 Nfatc2 Jun Ccnd1 Ywhab Pip5k1b Cdk6 Rhoa Rac1 Prkaca Mark2 Mapk8 Arrb2 IL6%NETPATH%IL6 IL6 Ar Rb1 Hdac1 Map3k7 Hspb1 Akt1 Pik3r1 Fgr Hck Mapk1 Mapk3 Shc1 Ep300 Hsp90aa1 Plcg1 Nlk Stat5a Prkcd Stat5b Btk Cdk9 Lyn Socs3 Map3k4 Pias3 Cd40 Tyk2 Sgk1 Il6st Hnrnpa1 Il6 Crebbp Bmx Jun Eif2a Map2k4 Il6ra Grb2 Nfkb1 Stat3 Cbl Erbb3 Gab2 Vav1 Ptpn11 Daxx Mapk14 Ptk2b Foxo4 Foxo3 Foxo1 Map2k2 Erbb2 Fos Rac1 Eif4ebp1 Gsk3b Fyn Jak1 Pik3r2 Map2k1 Eif4e Stat1 Mapk8 Gab1 Map2k6 Ncoa1 Bad TSH%NETPATH%TSH TSH Creb1 Gnao1 Tshr Hspa5 Canx Atp1a1 Gnai2 Gnai1 Scrib Calr Map2k3 Gnai3 Gnaq Mapk3 Raf1 Lep Map2k6 Igf1r Gna12 Gna11 Ikbkb Gna13 EGFR1%NETPATH%EGFR1 EGFR1 Huwe1 Tjp2 Cavin1 Cavin2 Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Stambp Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Ripk1 Sirpa Ralgds Dlg3 Crim1 Ddx6 Afap1l2 Tgif1 Sfpq Dapp1 Asap1 Iqgap1 Asap3 Anks1 Baiap2 Lsr Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Dock4 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Rgs16 Kras Mta2 Snrpd2 Egf Spry2 Spry3 Spry1 Reps2 Spry4 Pebp1 Ptpn23 Zpr1 Map2k2 Appl1 Dyrk1a Creb1 Hdac1 Pik3r1 Ptk2 Mapk1 Myc Jund Dab2 Sp1 Jun Pik3ca Trp53 Cav1 Stk11 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Gsk3b Crk Pik3r2 Ap2b1 Map2k3 Pard3 Prkd1 Crkl Plcg1 Cblb Plcg2 Prkcd Itsn2 Vasp Arhgef7 Pttg1ip Lyn Tfrc Pik3c2b Kirrel1 Shb Dyrk1b Cltc Nfkb1 Pgam1 Vav1 Vav2 Ldha Prpf4b Pak1 Caskin2 Git2 Mpzl1 Map2k1 Nedd9 Mapk7 Mapk8 Erbin Sdcbp Rela Dok1 Dok2 Pkp4 Flnb Raf1 Abl1 Ptpra Cdk1 Ddx3x Acp1 Nck1 Adam9 Pkm Lck Ywhaz Ubash3b Atp1a1 Ptpn6 Cebpb Ptpn12 Mapk14 Arhgap35 Ptk2b Khdrbs1 Erbb2 Eif4ebp1 Prkaa1 Prkaa2 Fyn Jak1 Nos3 Sh2b1 Egfr Gsk3a Cdk5 Rps6ka2 Socs1 Jak2 Sh3kbp1 Rps6ka1 Kit Prkca Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Pik3cg Ptpn18 Casp9 Erbb3 Gab1 Itch Mapk9 Map3k3 Ywhab Rps6ka5 Irs2 Rhoa Rac1 Plec Dsp Itgb4 Met Pik3r3 Col17a1 Ephb2 Pik3cb Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Prkcg Arhgef4 Jup Socs3 Map3k4 Pias3 Tyk2 Hnrnpa1 Scrib Il17rd Myl12b Mprip Elk4 Gja1 Tfg Ralb Otud6b Araf Frs2 Frs3 Arhgap5 Prkci S100a14 Arap1 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot1 Errfi1 Myo6 Garem1 mt-Co2 Antxr1 Arf4 Braf Clta Cyld Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl2 EG433182 Stx4 Inppl1 Pygb Pdzd11 Gsn Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Ensa Stat2 Pkn2 Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Atxn2 Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Cdh2 Plekhn1 Cfl1 Magi1 Hat1 Pkp2 Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Serpinb3d Abl2 Slc38a2 Ptpre Tnk2 Alb Bcl2 Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Sh3gl3 Epha1 Epha2 Epha4 Itgb1 Dsg2 Ctnnal1 Cd59b Wbp2 Sri Ephb1 Cebpa Ephb3 Ephb4 Ahcyl1 Ptpn1 Slitrk6 Csk Arhgap32 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Arhgap42 App Spart Nectin1 Rps10 Tns4 Scamp3 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Pfn1 Tln1 Rin1 H3c8 Hnrnpr Sdc4 Sdc3 Insr Stam Atp5f1c Usp6nl Slc5a5 Snx5 Tollip Pdcd6ip Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Ptprk Ptprf Dcbld2 Rps27l Git1 Cdv3 Laptm4a Plekha6 Plekha5 Mink1 Actn1 Actn4 Plscr1 Gprc5a Map2k7 Aldoa Ncoa3 Limd1 Cstb Krt18 Krt17 Racgap1 Wasl Cttn Axl Ctnnd1 ID%NETPATH%ID ID Map2k2 Rb1 Psmd4 Fhl2 Tcf7l2 Pax5 Elk1 Elk3 Rbl1 Atf3 Hes1 Id3 Rbl2 Smurf2 Tcf3 Myf5 Mapk1 Elk4 Map2k1 Mapk3 Raf1 Smad3 Cdk2 IL9%NETPATH%IL9 IL9 Mapk3 Tyk2 Kat5 Mapk1 Stat5a Stat6 Stat5b Il9r IL3%NETPATH%IL3 IL3 Creb1 Ywhab Ywhaz Pik3r1 Nfkb1 Ptk2 Ptpn6 Dok1 Prkcb Mapk1 Ppp2ca Prkca Socs2 Bcl2l11 Kcnip3 Gab2 Rara Inpp5d Slc2a1 Shc1 Gata2 Crkl Csf2rb2 Ptprc Fes Foxo1 Hras Rxra Gsk3b Crk Pik3r2 Map2k1 Lyn Prkaca Socs3 Gsk3a Gab1 Bcl2l1 Rack1 Pik3cd Bad IL5%NETPATH%IL5 IL5 Ywhaz Nfkb1 Bax Atf2 Stat3 Hck Cbl Rps6ka1 Syk Raf1 Shc1 Ptpn11 Alox5 Il2rb Crkl Mapk14 Pla2g4a Il5 Sox4 Ptk2b Il5ra Stat5a Stat5b Prkcd Foxo3 Map2k2 Hras Elk1 Unc119 Gsk3b Jak1 Lyn Rapgef1 Ctnnb1 Pik3cg Stat1 Gsk3a Nfkbia Dnm2 Rack1 Jun Socs1 Hcls1 Grb2 Sdcbp Sos1 IL4%NETPATH%IL4 IL4 Akt1 Jak2 Ptk2 Atf2 Mapk1 Ets1 Mapk3 Inpp5d Shc1 Ep300 Plcg2 Prkcd Elk1 Rasa1 Cebpa Cd40 Tyk2 Nfkbia Crebbp Pik3ca Ikbkb Nfkb1 Ptpn6 Stat3 Cbl Cebpb Syk Ptpn11 H3c8 Mapk14 Stam Spi1 Il13 Cxcr4 Il13ra1 Snd1 Chuk Il4 Grk3 Mapk11 Il2rg H3c7 Irs2 Jak1 Mapk8 Ncoa3 Pik3cd Socs1 Bad IL-7%NETPATH%IL-7 IL-7 Akt1 Pik3r1 Stat3 Jak3 Mapk1 Il7r Mapk3 Shc1 Stam Cblb Stat5a Stat5b Foxo3 Foxo1 Map2k2 Il2rg Irs1 Irs2 Il7 Gsk3b Fyn Map2k1 Stat1 Gsk3a Bad NOTCH%NETPATH%NOTCH Notch Kat2b Akt1 Jak2 Pik3r1 Rela Mapk1 Mapk3 Ep300 Skp1 Lef1 Rbx1 Smad1 Hdac2 App Src Nfkb1 Hes1 Stat3 Tcf3 Cul1 Sin3a Fhl1 Mfng Ccn3 Gsk3b Skp2 Sap30 Hes6 Maml3 Notch4 Notch2 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll3 Dll4 Maml1 Ring1 Maml2 Fbxw7 Furin Jag2 Cirsr Rbpj Yy1 Smad3 Lfng IL2%NETPATH%IL2 IL2 Il15 Creb1 Stat4 Il2ra Ybx1 Ets2 Akt1 Plcb1 Pik3r1 Tert Atf2 Rela Nr3c1 Ccne1 Itm2b Eif3b Il2 Mapk1 Prkcz Nmi Vil1 Ets1 Mknk1 Mapk3 Raf1 Shc1 Mtor Crkl Hsp90aa1 Stat5a Stat5b Cdk2 Bcl2 Elk1 Lyn Socs3 Pik3cg Stam2 Sgk1 Jun Lck Pik3ca Grb2 Sos1 Shb Nfkb1 Ptpn6 Jak3 Cbl Gab2 Vav1 Ptpn11 Il2rb Mapk14 Ptk2b Stam Foxo3 Map2k2 Il2rg Irs1 Irs2 Eif4ebp1 Crk Fyn Jak1 Pik3r2 Map2k1 Pik3r3 Eif4e Mapk8 Pik3cb Pik3cd TSLP%NETPATH%TSLP TSLP Relb Stat4 Akt1 Nfkb1 Rela Stat3 Mapk1 Stat6 Map2k1 Nfkb2 Mapk9 Mapk3 Eif4e Stat1 Mapk14 Mapk8 Nfkbia Stat5a Stat5b RANKL%NETPATH%RANKL RANKL Map3k7 Ptk2 Nfkb1 Rel Nfkb2 Traf3 Tnfsf11 Tab1 Atp6v1e1 Tab2 Sqstm1 Tnfrsf11b Mapk14 Trem2 Mapk8 Traf2 Traf6 Traf1 Traf5 Spi1 Mitf Chuk IL1%NETPATH%IL1 IL1 Rb1 Akt1 Pik3r1 Nfkb1 Atf2 Rela Map2k3 Dok1 Ppp6c Elp1 Mapk1 Mapk9 Mapk3 Tab1 Mapk14 Pla2g4a Peli1 Ube2v1 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Chuk Myd88 Il1a Fbxw5 Map3k2 Il1b Peli2 Il1r2 Il1r1 Il1rn Rel Pik3r2 Tab3 Tab2 Mapk8 Traf6 Nfkbia Map2k6 Jun Ikbkb Map3k14 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Hk2 Hk1 Rpia Gpi Hkdc1 Taldo1 Pgd Tkt ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Hk2 Hk1 Gale Galt Aldob Aldoc Hkdc1 Aldoa Khk P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Tab1 Mapk11 Traf6 Srf VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Rac2 Kdr Akt1 Rac3 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Pik3ca Nos3 Il10 Ikbkb Il11 Mapk7 Spi1 Il15 Irs1 Cxcr1 Stat6 Cxcr2 Stat4 Il13 Il18 Il2ra Il2rb Irs2 Il15ra Mapk6 Sla2 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il20ra Il23a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Il5ra Rps6ka2 Sos2 Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Mtor Srf Il2 Il4 Elk1 Il6 Il5 Il7 Il9 Il21 Il12rb1 Mapk15 Il12rb2 Spic Mapkapk2 Il1a Stat5a Stat5b Il6ra Il4ra Stat3 Stat2 Mknk2 Stat1 Mknk1 Chuk Cdkn1a Cdkn1b Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Flad1 Rfk HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Ears2 Cox10 Alad Qars1 Rsad1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Gng2 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Clock Csnk1d Csnk1e Bmal1 Per2 Per1 Per3 Cry1 Cry2 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Sqle Fdps Mvk Pmvk Ggps1 Hmgcr Mvd Pdss1 Fdft1 Lss IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm3 Grm2 Slc1a1 Slc1a3 Slc1a2 Slc1a7 Grin1 Slc1a6 Slc17a8 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Gria1 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Stx11 Grin2b PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pten Pik3c2g Rbl1 Pik3cg Cdk2 Pik3r5 Pik3cb Siah1a Pik3cd Mapk12 Atm Pik3ca Trp73 Mapk13 Mapk14 Pik3c2b Pik3c2a Hras Cdkn1a Mapk11 Pik3c3 Pdpk1 Akt1 Akt3 Akt2 Nras Ccne1 Ccng1 Ctnnb1 Trp63 Kras Pik3r1 Ppp2cb Pik3r2 Rb1 Pik3r3 Ppp2ca Trp53 Tpte THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Prkcz Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Hrh1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Itpr1 Prkar1a Prkar1b Grik5 Prkx Prkacb Grina Grm1 Grik1 Plcb4 Grm5 Homer1 Gna11 Grin2d Grin2c Grin2a Grin2b Prkaca Prkcb Gnaq Grin1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Elk1 Map2k6 Mapk12 Mapk13 Myc Mapk14 Eef2k Mapk9 Jun Map2k4 Mapk8 Max Ddit3 Mef2c Txn Mknk2 Stat1 Map2k3 Mknk1 Bcl2 Mapk11 Pla2g4a 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Gng2 Adcy2 Prkaca Kcnk9 Gnao1 Adcy7 Prkar2a Prkar2b Htr1d Gnb1 Htr1f Gnai2 Gnai1 Htr1b Htr1a Gng11 Gnai3 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Prkcz Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca Oxtr 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Htr4 Gnal Gng12 Gng2 Gng10 Adcy2 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Adcy9 Kcnj3 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Cacna1g Prkar1a Prkar1b Prkacb Adcy2 Prkaca Gnao1 Adcy7 Prkar2a Prkar2b Gnb1 Gnai1 Gng11 Gnai3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2v2 Uba6 Ube2k Uba7 Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2e1 Ube2g2 Ube2g1 Ube2l6 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb2 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Wnt5a Kat5 Cdh1 Trpc1 Trpc4 Gsk3b Wnt5b Wnt9a Kat7 Wnt9b Fzd10 Ctnnb1 Wnt10a Bace2 Wnt10b Bace1 Acta1 Acta2 Actb Actr2 Notch4 Ern1 Notch1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Fstl1 Wnt16 Lrp1b Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Actg1 Wnt4 Cd44 Wnt3 Tcf7l2 Fzd1 Fzd3 Actc1 Actbl2 Fzd2 Fzd5 Trim3 Jup Fzd4 Trim2 Fzd7 Fzd6 Fzd9 Fzd8 Rbpj Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh8a1 Aldh7a1 Aldh9a1 Il4i1 Aldh1l1 Aldh1l2 Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh4a1 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Trp73 Cop1 Trp63 Trp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Dcakd Pank3 Pank2 Pank4 Pank1 Ppcs METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Nfkbil1 Cd22 Vav3 Syk Vav1 Vav2 Map3k3 Map3k2 Blnk Btk Cd79a Cd79b Ptpn6 Ppp3ca Lyn Ptprc Ppp3cb Nfkbia Cd19 Grb2 Mapk10 Fos Sos2 Sos1 Mapk12 Mapk13 Mapk14 Chuk Mapk11 Mapk1 Itpr3 Mapk3 Itpr2 Itpr1 Rac2 Rac1 Araf Mapk9 Plcg2 Jun Mapk8 Nras Prkcb Prkcd Raf1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt1 Akt3 Trp73 Eif4ebp1 Tsc2 Akt2 Tsc1 Igbp1 Prkaa1 Prkab2 Prkaa2 Rps6kb2 Prkab1 Prkag1 Trp63 Ppp2cb Ppp2ca Trp53 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb2 Liph Plcb1 Dagla Lpl Pla1a Plcb3 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Pmm2 Gmds Gmppb Pmm1 Mpi MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrpa Snrnp40 Zrsr2 Prpf3 Snrpb2 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Arnt Hif1a Rorc Txn2 Crebbp Egln2 Egln3 Akt1 Akt3 Vhl Akt2 Txn Mtor THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Crebbp Gtf2a1l Polr2c Taf1c Taf9 Ep300 Creb3l3 Creb3l4 Polr2h Polr2e Creb3l1 Ttf2 Creb3l2 Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Tbp Brf2 Brf1 Prkar1a Tbpl2 Prkar1b Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Gtf2b Mterf2 Taf8 Taf7 Taf6 Taf4 Gtf2e1 Taf2 Gtf2e2 Prkar2a Prkar2b OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gng12 Gng2 Gng10 Adcy2 Oprd1 Pomc Gnao1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 Glul UNTITLED%PANTHER PATHWAY%P00019 untitled Edn1 Edn2 Gnal Edn3 Adcy10 Gucy1b1 Prkcz Prkg2 Adcy4 Prkg1 Adcy1 Gucy1a1 Adcy8 Gucy1a2 Adcy5 Nos3 Adcy6 Adcy9 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Mapk1 Pla2g4a Itpr3 Mapk3 Itpr2 Itpr1 Prkar1a Prkar1b Akt1 Prkacb Araf Prkcq Adcy2 Prkcg Prkch Prkci Prkaca Prkcb Adcy7 Prkcd Prkar2a Prkce Prkar2b Prkca Raf1 Ednrb Ednra Adcy3 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Tyms Gch1 Fpgs 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Prkcz Plcb4 Plcb3 Gna11 Htr2a Gng10 Htr2c Gna14 Htr2b Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca Gng11 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Col6a2 Ptk2b Col6a3 Lims2 Lamc3 Rapgef1 Lamc1 Lamc2 Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Braf Pik3c3 Mapk3 Rac2 Rac1 Araf Mapk9 Mapk8 Nras Map2k3 Raf1 Pik3r1 Pik3r2 Pik3r3 Pxn Pik3cg Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Ptk2 Map2k2 Col14a1 Map2k1 Map3k5 Hras Itgbl1 Crkl Arfgap1 Col10a1 Col1a2 Col5a2 Col5a3 Col5a1 Dmbt1 Col9a2 Col9a3 Col9a1 Lama5 Arpc1b Arpc1a Lama1 Lama2 Mapk6 Lama3 Lama4 Flnb Tln1 Vcl Vasp Col17a1 Col13a1 Fn1 Itga7 Itga8 Arl1 Itga5 Itga6 Itga9 Itga3 Itga4 Elmo2 Itga1 Itga2 Elmo1 Itga10 Sos2 Itga11 Sos1 Col4a3 Shc1 Col4a4 Arpc3 Col4a1 Cav1 Actb Arpc2 Col4a2 Col4a5 Col8a1 Col4a6 Col8a2 Parvb Arpc5 Parva Rap2b Col16a1 Rap2a Arf1 Rap2c Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rhob Rnd1 Itgam Asap1 Itgae Arhgap10 Itgal Rap1a Rap1b Itgad Itgb8 Itgb6 Actg1 Itgb7 Itgb1 Itga2b Actn2 Itgb4 Rras Itgb5 Itgb2 Actn1 Actbl2 Actn4 Col20a1 Crk Arf6 Arpc5l Arhgap26 Col15a1 Col11a1 Col11a2 Src Ntn4 Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Flna Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Ehf Srgap1 Srgap3 Rab11b Arhgap6 Arhgap5 Arhgap4 Erf Erg Arhgap9 Shc3 Rasa1 Rasa4 Pdgfrb Vav3 Pdgfra Pdgfa Vav1 Pdgfrl Vav2 Pdgfb Map3k2 Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Grb2 Gab2 Etv3 Mapk10 Spdef Elf1 Gsk3a Elf2 Elf3 Elf4 Elf5 Rps6kb2 Ophn1 Mycbp Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Srf Elk1 Map3k4 Pik3r5 Mapkapk2 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Mapk1 Braf Ets1 Itpr3 Pik3c3 Mapk3 Itpr2 Itpr1 Plcg1 Araf Plcg2 Jun Mapk8 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Mapk7 Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Mapk15 Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Arhgap10 Arhgap26 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Myo3a Actr1b Acta1 Myo3b Acta2 Chrnb1 Actb Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh1 Myh2 Myh3 Myh15 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myh14 Myh13 Myo1g Myo1f Plekhh3 Myh10 Myo18a Myo6 Myo18b Myo5a Myo9a Actg1 Slc5a7 Chrnd Chrne Chrng Chrna2 Chrnb4 Chrna1 Myo10 Actc1 Chrna9 Actbl2 Myo15a Chrnb3 Myo16 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Jak2 Stat1 Jak1 Stat6 Jak3 Stat5a Stat4 Stat5b Stat3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psat1 Phgdh Psph AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3cg Pik3r5 Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Rac2 Vasp Rac1 Plcg1 Ntn1 Plcg2 Ntn3 Nfatc4 Rhou Nfatc3 Nfatc2 Ntn4 Ablim1 Dcc Ntng1 Unc5b Unc5d Unc5c Pik3r1 Pik3r2 Pik3r3 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a2 Slc6a3 Slc6a19 Slc6a18 Slc6a15 Slc6a17 Slc18a2 Slc6a20a Slc6a16 Slc18a1 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Fmo3 Ugt1a2 Cyp2a5 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat2a Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Pak4 Tubb5 Tubb6 Arpc1b Tubb3 Arpc1a Tubb1 Wasl Mylk Limk1 Arpc4 Rock2 Tubb4b Tubb4a Rock1 Myo3a Arpc3 Acta1 Myo3b Acta2 Actb Arpc2 Myh1 Myh2 Arpc5 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Rhoc Myh11 Myh14 Myh13 Myh10 Actg1 Rac2 Actc1 Rac1 Actbl2 Rhou INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Elk1 Map2k2 Rps6ka4 Rps6ka5 Map2k1 Rasa1 Irs1 Mapk1 Irs2 Mapk3 Ins2 Insr Irs4 Igf2r Igf2 Igf1 Fos Insrr Rps6kb2 Igf1r Rps6ka3 Map2k3 Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Jak2 Ifng Stat1 Jak1 Ifngr1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 Uckl1 Adat2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Cacna1a Cacna1b Adcy10 Grin2a Slc1a1 Slc1a3 Slc1a2 Slc1a7 Grin1 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Gria1 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Cacna1e Grm4 Grm7 Grm8 Vti1a Stx1b Cacnb1 Stx1a Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Grm1 Grm5 Prkaca Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gnai3 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Pik3cg Pik3cb Pik3cd Pik3ca Casp9 Map3k5 Ikbkb Nfkbia Akt3 Mapk10 Akt2 Igf2r Fos Trp53 Atf2 Eif2ak2 Birc3 Birc2 Tnf Madd Map2k4 Bcl2l11 Tnfrsf1b Tnfrsf1a Tradd Nfkb2 Chuk Nfkb1 Traf2 Bcl2l1 Xiap Endog Tnfsf10 Rela Mapk1 Relb Map3k1 Apaf1 Tnfrsf10b Lta Fadd Atf7 Mapk3 Ltb Atf6 Atf4 Atf3 Jdp2 Akt1 Aifm1 Gzmb Map2k7 Gzmf Map4k4 Map4k3 Mapk9 Prkcq Fasl Atf6b Jun Mapk8 Prkcg Cradd Prkch Bak1 Eif2s1 Casp8 Prkcb Casp7 Map2k3 Prkra Bcl2 Casp3 Prkcd Bik Ripk1 Prkce Map4k2 Prkca Diablo Bax Rel Fas Daxx Map3k14 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Ralb Exoc2 Pld1 Pld2 Pik3cg Ralgds Pik3cb Rgl1 Pik3cd Pik3ca Map2k2 Map2k1 Hras Pak1 Pak3 Pak2 Pdpk1 Grb2 Akt3 Mapk10 Gsk3a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Kras Srf Elk1 Map2k6 Map3k4 Mapk12 Mapkapk3 Atf2 Mapk13 Mapk14 Mapkapk2 Map2k4 Stat3 Rhoc Stat1 Rhoa Rhob Mapk11 Mapk1 Map3k1 Braf Ets1 Pik3c3 Mapk3 Rac2 Akt1 Rac3 Rac1 Map2k7 Araf Mapk9 Jun Mapk8 Nras Map2k3 Raf1 Tiam1 Rala ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Elk1 Grk3 Grk2 Agtr1a Arrb2 Arrb1 Plcb3 Egr1 Agt Gng10 Map2k2 Map2k1 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Mapk1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Mapk3 Itpr2 Itpr1 Gnb1 Prkca Raf1 Gng11 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Gtf2b Mterf2 Taf8 Taf7 Taf6 Taf4 Gtf2e1 Taf2 Gtf2e2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Pten Cdk2 Crebbp Mdm2 Atm Pik3ca Mdm4 Trp73 Gadd45g Sin3a Ep300 Chek2 Sumo3 Gadd45b Gadd45a Wrn Cdkn1a Hdac1 Traf2 Sfn Cdkn2a Mta2 Kat2b Gtse1 Pml Cdk1 Sirt1 Cdc25c Pdpk1 Akt1 Akt3 Akt2 Ccne1 Trp63 Trp53 Tpte THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Cacna1a Cacna1b Prkcz Vamp8 Vamp1 Trh Vamp3 Trhr Vamp2 Stx3 Cga Snap29 Cacnb3 Cacnb4 Cacnb2 Snap25 Tshb Snap23 Cacna1e Cacnb1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Gnb1 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Hsd17b3 Soat2 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Ctnnb1 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Ctnnd2 Pcdhga1 Ctnnd1 Pcdhga2 Pcdhga3 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Acta1 Acta2 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Actg1 Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Actc1 Actbl2 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc2 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Pdha2 Mdh1 Suclg1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin2 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 Mmut LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Dpysl2 Dpysl3 Cda Upb1 Dpysl5 Nt5e Aldh6a1 Dpys Dpyd Abat ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gnal Gng12 Prkx Prkacb Adrb1 Gng2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Irs2 Pten Pdpk1 Mdm2 Pik3ca Mdm4 Ins2 Insr Tsc2 Irs4 Tsc1 Gsk3a Igf2r Foxo3 Foxo1 Igf2 Igf1 Insrr Igf1r Gsk3b Irs1 Tpte HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gnal Gng12 Prkx Prkacb Gng2 Hrh2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gnal Gng12 Gng2 Gng10 Adrb3 Adcy2 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Xdh Nt5e Ampd3 Gda METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gnal Gng12 Gng2 Gna11 Gng10 Gna14 Crh Crhr2 Pomc Crhr1 Gng3 Gng4 Gng7 Gnaq Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Apba3 Pkn1 Prkcz Psen1 Mapk12 Cacnb1 Mapk15 Mapk13 Psen2 Mapk14 Ncstn Aph1b Mapk7 Mapk11 Mapk1 Mapk3 Mapk6 Cacna1c App Cacnb2 Mapk10 Mapk9 Prkcq Mapk8 Prkcg Kat5 Prkch Prkci Prkcb Cacna1f Cacna1d Prkcd Pkn3 Pkn2 Klc1 Prkce Adam17 Prkca Mapk4 Bace2 Klc4 Klc3 Bace1 Klc2 Cacna1s Apba1 Apba2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Cxcl12 Slit1 Rac2 Slit2 Slit3 Robo1 Cxcr4 Rac1 Srgap1 Abl1 Ntn1 Ntn3 Rhoc Ntn4 Dcc Ntng1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Nme1 Nme3 Dscaml1 Nme2 Dhodh Nme4 Cad Ctps2 Cps1 Ctps1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Map2k2 Map2k1 Map3k5 Hras Shc3 Rasa1 Rasa4 Stat6 Map3k3 Map3k2 Grap Stat4 Erbb4 Gab1 Gab2 Akt3 Mapk10 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Pik3r5 Mapk12 Mapk13 Mapk14 Stat5a Stat5b Map2k4 Stat3 Stat2 Erbb2 Stat1 Erbb3 Mras Rasal2 Gab3 Egfr Phldb2 Mapk11 Nf1 Prkd3 Rras2 Mapk1 Dab2ip Pebp4 Prkd1 Spry2 Braf Spry3 Prkd2 Spry1 Spry4 Pik3c3 Pebp1 Mapk3 Rac2 Rras Akt1 Rac1 Map2k7 Plcg1 Araf Mapk9 Prkcq Plcg2 Mapk8 Prkcg Prkch Prkci Nras Prkcb Map2k3 Prkcd Prkce Prkca Raf1 Shc2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Mmp3 Fgg Plat Plg Mmp9 Mmp1a Plau Serpinf2 Serpine1 Plaur Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Slc6a3 Gng3 Gng4 Gng8 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Stx3 Snap29 Epb41l2 Snap25 Clic6 Prkx Snap23 Ppp1r1b Prkacb Kcnk3 Slc18a2 Adcy2 Drd2 Epb41l3 Drd4 Drd1 Ppp1ca Drd5 Prkaca Ppp1cc Kcnk9 Gnaz Epb41 Adcy7 Prkar2a Prkar2b Gnb1 Flna Gnai2 Gnai1 Gng11 Gnai3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Crebbp Shh Smo Ptch1 Sufu Stk36 Fbxw11 Gli1 Btrc Gli3 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Chrm2 Slc18a3 Chrm4 Slc6a8 Gnat2 Adcy10 Gnat1 Kcnj3 Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Slc5a7 Prkar1a Prkar1b Prkx Prkacb Prkaca Gnao1 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Kcnj9 Gng11 Kcnj6 Gnai3 Kcnj5 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gnpda1 Amdhd2 Gnpda2 Gfpt1 Gfpt2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Bmp10 Bmp8a Skil Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Hras Jund Acvr1c Snip1 Lefty1 Tgfb2 Gdnf Tgfb3 Acvrl1 Cited1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Bmpr1b Gdf3 Gdf6 Bmp7 Gdf5 Bmp6 Gdf7 Mapk10 Bmp5 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Bmp1 Smad4 Smad9 Acvr2a Tll2 Tll1 Gdf15 Inhba Acvr2b Inhbb Junb Inhbc Tgfbr1 Smad5 Smad6 Tgfbr2 Map3k7 Smad7 Gdf11 Crebbp Inhbe Gdf10 Mapk12 Atf2 Mapk13 Mapk14 Ep300 Tab1 Mapk11 Mapk1 Mapk3 Rras Mapk9 Jun Mapk8 Nras BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F2r Klkb1 Gp5 Kng2 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz F2 Tfpi F3 Serpina10 F7 Thbd F8 F9 Pros1 F2rl3 Fgb Fga Itga2b Fgg Plat Plg Plau Plaur PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Gnat2 Pik3r5 Pik3cb Pik3ca Casp9 Nos3 Gna11 Gna14 Irs1 Gnaq Gngt2 Gnb2 Gnb4 Ptger1 Gnb3 Foxo4 Gnb5 Gngt1 Ywhaz Pdpk1 Akt1 Akt3 Insr Akt2 Foxo3 Foxo1 Rps6kb2 Nras Gsk3b Sos2 Gnb1 Sos1 Gnai2 Gnai1 Pik3r1 Pik3r2 Pik3r3 Gnai3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Chrm2 Chrm4 Grm3 Grm2 Gsk3a Crebbp Gng10 Ep300 Creb3l3 Creb3l4 Creb3l1 Hrh1 Gng3 Creb3l2 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gngt1 Gng12 Adora2b Adora2a Adra2c Prkar1a Adra2b Prkar1b Htr6 Htr7 Prkacb Oprl1 Phka1 Grm1 Phka2 Grm5 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Sstr3 Oprd1 Sstr2 Sstr1 Oprm1 Htr5a Adcy7 Phkb Prkar2a Chrm1 Prkar2b Chrm3 Htr1d Chrm5 Htr1f Hrh4 Gnai2 Hrh3 Htr1b Adora1 Htr1a Adora3 Gnrhr Gnai3 Gys1 Adcy3 Htr4 Gys2 Gnal Clta Cltb Cltc Mtnr1a Creb1 Adcy4 Creb3 Adcy1 Phkg1 Adcy8 Phkg2 Adcy5 Mtnr1b Adcy6 Pygb Adcy9 Pygl Kcnj3 Htr2a Pygm Htr2c Gpr50 Htr2b Oprk1 Adrb1 Hrh2 Adrb3 Gsk3b Grm4 Grm7 Grm8 Rap1a Rap1b Gng2 Adcy2 Drd2 Drd4 Drd1 Drd5 Prkaca Gnb1 Gnai1 Kcnj9 Kcnj6 Kcnj5 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Map2k2 Map3k6 Map2k1 Map3k5 Frs2 Hras Frs3 Shc3 Fgfr3 Rasa1 Fgfr4 Rasa4 Fgfr1 Fgfr2 Map3k3 Map3k2 Grap Ptpn6 Akt3 Mapk10 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Mapk11 Mapk1 Spry2 Spry3 Spry1 Spry4 Pik3c3 Pebp1 Mapk3 Rac2 Akt1 Rac1 Map2k7 Plcg1 Araf Mapk9 Prkcq Plcg2 Mapk8 Prkcg Prkch Prkci Nras Prkcb Map2k3 Prkcd Prkce Prkca Raf1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Asl Nags Otc Ass1 Cad Cps1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnat1 Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Cnga3 Pdc Cnga1 Gnb2 Grk1 Gnb4 Pde6g Rho Gnb5 Calml3 Gngt1 Rgs9 Gng12 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng2 Gnb1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Stx12 Elk1 Slc6a3 Gpr37 Ndufv2 Pld2 Psma7 Snca Mapk12 Mapk15 Mapk14 Mapk7 Sfn Mapk1 Mapk3 Ywhaz Psma4 Mapk10 Psma3 Psma6 Psma5 Ccne2 Mapk9 Psma2 Psma1 Mapk8 Cask Ywhah Ywhag Ywhae Th Ywhab Ccne1 Psmb10 Sncaip Psmb7 Prkn Psmb1 Septin5 Gpr37l1 Septin4 Psmb3 Stx7 Septin2 Septin1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Slc18a3 Pkn1 Prkcz Plcb4 Gna11 Gng10 Grin2a Gna14 Gng3 Gng4 Gng7 Gnaq Grin1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Slc5a7 Itpr3 Itpr2 Itpr1 Prkcq Grin2d Grin2c Prkcg Prkch Grin2b Prkci Prkcb Prkcd Pkn3 Pkn2 Chrm1 Prkce Chrm3 Gnb1 Prkca Gng11 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gng12 Pdyn Penk Gng2 Gng10 Adcy2 Oprd1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc5 Pold2 Pold1 H3c8 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pola1 Rpa2 Top2b Prim1 Top2a Top1 Dna2 H3-3b METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pcca Pccb Mmut DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Ak3 Ak2 Nme5 Ak5 Adss2 Adss1 Ak8 Atic Nme7 Ppat Dscaml1 Nme6 Guk1 Gart Nme1 Nme3 Rrm1 Nme2 Rrm2 Nme4 Adsl Rrm2b Ak1 Gmps VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Gc Rxra F13b Vdr Rara HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Chrm2 Clta Chrm4 Cacna1a Cltb Cacna1b Cltc Prkcz Oprk1 Grm3 Grm2 Gng13 Cacna1e Grm4 Grm7 Grm8 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Rhoa Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Rap1a Rap1b Gnb2 Gnb4 Gnb3 Gngt1 Itpr3 Gng12 Adora2b Itpr2 Adora2a Itpr1 Oprl1 Grm1 Grm5 Gng2 Prkcq Prkcg Drd2 Sstr5 Prkch Drd4 Sstr4 Prkci Drd1 Rap1gap Sstr3 Drd5 Oprd1 Sstr2 Prkcb Rasgrp3 Sstr1 Rasgrp4 Oprm1 Rasgrp1 Gnao1 Prkcd Rasgrp2 Arhgef1 Dnajc27 Prkce Garnl3 Chrm1 Prkca Bdkrb2 Chrm3 Gnb1 Bdkrb1 Chrm5 Gpr45 Adora1 Adora3 Gnrhr ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Axin1 Grb7 Pdgfc Pld1 Pdgfd Pld2 Tcf7 Efnb1 Efnb2 Jag2 Jag1 Pla2g4c Pla2g4d Birc5 Angpt1 Apc2 Epha3 Ephb1 Dll1 Ephb2 Ephb3 Rasa1 Dll3 Dll4 Pdgfrb Dlk1 Pdgfra Apc Pdgfa Tek Pdgfb Grap Nck2 Jak1 Nck1 Ctnnb1 Hspb1 F2r Mapkapk3 Mapk14 Mapkapk2 Map2k4 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Kdr Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Jun Mapk8 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Frs2 Hras Frs3 Crkl Fgfr1 Pak1 Pak3 Pak2 Akt3 Akt2 Wnt5a Fos Gsk3b Wnt5b Sos2 Wnt10a Sos1 Wnt10b Shc1 Notch4 Notch1 Notch2 Stat3 Rhoc Stat1 Rhoa Rhob Rbpjl Wnt7b Dvl1 Dvl2 Map3k1 Dvl3 Wnt7a Wnt2 Wnt1 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Crk Src Rbpj Wnt2b Grb14 Fgf1 Dok1 Dok2 Dok3 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Nme1 Tyms Dut Dtymk Nme3 Dscaml1 Rrm1 Nme2 Rrm2 Nme4 Rrm2b Adat2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt7 Syt6 Unc13c Rab3a Stxbp1 Snap25 Stx1b Unc13b Syt15 Stx1a Stx2 Unc13d Syt5 Syt3 Syt2 Vamp1 Syt1 Syt11 Syt12 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Ptk2b Arrb2 Egr1 Ppp3ca Jak2 Lyn Nfkbia Grb2 Mapk10 Eif4ebp1 Nr2c2 Clu Ier3 Sp1 Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Ryr2 Ryr1 Hbegf Ryr3 Nos1 Ctnnb1 Hdac7 Akap1 Cckbr Pparg Gucy2e Arhgef28 Traf6 Cd38 Ptgs2 Srf Camk4 Mef2d Elk1 Map2k5 Ptpn11 Map2k6 Tpcn1 Tpcn2 Hspb1 Bad Cck Gast Map3k11 Mapk14 Eif4e Map2k4 Mef2c Mapk1 Pla2g4a Prkd1 Braf Prkd2 Mapk3 Itpr1 Akt1 Prkacb Rac1 Plcg1 Araf Mapk9 Prkcq Jun Mapk8 Prkch Prkcb Nfatc2 Bcl2 Prkcd Prkce Prkca Raf1 Pik3r1 Pxn Pik3cb Creb1 Prkg1 Adcy1 Ptk2 Map2k2 Map2k1 Mapk7 Pak1 Irs1 Odc1 Elk4 Pdpk1 Rock1 Foxo3 Foxo1 Fos Cdh1 Rps6ka3 Gsk3b Ywhab Rps6ka1 Sos1 Shc1 Atf2 Itgav Stat3 Rhoa Bcl2l1 Itgb1 Mmp3 Plau Crk Gng2 Slc18a2 Prkaca Src Casp3 Bcar1 Gnb1 Bax Map3k14 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Tpi1 Pklr Gpi Bpgm Hkdc1 Eno2 Pfkl Pkm EG433182 Hk2 Pgk1 Hk1 Pgam2 Pfkm Aldoa NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 Ncor2 Rbpj Dll3 Cirsr Dll4 Dlk1 Maml1 Rbpjl Numb GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Aldh5a1 Abat Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Map2k4 Map3k5 Faf1 Parp4 Apaf1 Parp3 Parp2 Parp1 Fadd Cflar Lmnb1 Lmnb2 Gsn Casp6 Capg Lmna Scin Mapk10 Dffb Mapk9 Fasl Jun Mapk8 Casp8 Casp7 Casp3 Fas Daxx INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Col6a2 Ptk2b Col6a3 Jund Vav1 Grap Jak2 Kras Myo3a Junb Myo3b Myh1 Myh2 Myh3 Myh8 Myh9 Plcb4 Myh4 Plcb3 Myh6 Myh7 Gna11 Gng10 Gna14 Plcd1 Plcb2 Vwf Plcd4 Plcb1 Myh11 Gng3 Myh14 Gng4 Myh13 Gng7 Gnaq Gng8 Mapk1 Myh10 Plcz1 Plce1 Gnb3 Itpr3 Mapk3 Gng12 Itpr2 Itpr1 Rac2 Akt1 Prkx Prkacb Rac1 Cxcr3 Cxcr5 Plcg1 Cxcr6 Araf Cxcl10 Plcg2 C5ar1 Jun Fpr1 Ccr10 Nfatc4 Ccr1 Nras Xcr1 Nfatc3 Prkcb Ccrl2 Nfatc2 Ltb4r2 Gnao1 Rhog Fpr-s1 Ccr9 Prkce Ccr8 Ccr7 Raf1 Ccr6 Nfatc1 Gnai2 Ccr5 Ccr4 Ccr3 Ccr2 Gnai3 Cx3cr1 Ifnar1 Camk2d Ccl11 Pik3cg Ccl12 Prkcz Ccl7 Pik3cb Camk2a Pik3cd Ccl5 Pik3ca Ccl4 Ccl3 Adcy5 Ccl2 Adcy6 Pf4 Prex1 Cx3cl1 Nfat5 Ccl22 Col14a1 Mylk2 Ccl20 Mylk3 Ikbkb Pak1 Pak6 Cxcr1 Pak3 Pak2 Cxcr2 Pak5 Pak4 Arpc1b Arpc1a Mylk Arpc4 Pdpk1 Akt3 Rock1 Akt2 Cask Ifng Sos1 Shc1 Arpc3 Acta1 Acta2 Actb Arpc2 Il2 Arpc5 Cxcr4 Col12a1 Stat3 Rhoc Nfkb2 Chuk Rhoa Rela Relb Itgal Actg1 Itgb7 Itgb1 Rras Actc1 Actbl2 Col20a1 Gng2 Adcy2 Arpc5l Prkaca Gnai1 Col6a1 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Pnp Hprt1 Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Cltb Tubb2b Tubb2a Grin2a Hip1 Bdnf Ift57 Dync1h1 Dnal4 Dctn1 Grin1 Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Tubb5 Ap2a1 Tubb6 Arpc1b Hip1r Tubb3 Arpc1a Hap1 Tubb1 Kalrn Htt Gapdhs Dync1li2 Dync2h1 Dync1li1 Grik5 Tubb4b Dnai2 Tubb4a Dynll1 Dynll2 Grik2 Capn9 Grik1 Cyc1 Grik4 Capn5 Grik3 Sp1 Capn7 Grin2d Capn6 Grin2c Fos Capn1 Capn3 Grin2b Capn2 Dnah3 Dnah5 Dlg4 Dnah8 Cyfip2 Cyfip1 Capns1 Capn10 Trp63 Capns2 Capn11 Acta1 Acta2 Actb Trp53 Actr2 Crebbp Arpc5 Trp73 Map2k4 Ep300 Map3k10 Apaf1 Actg1 Tbp Rac2 Actc1 Rac1 Map2k7 Actbl2 Mapk9 Arpc5l Jun Taf4 Casp8 Rhog Casp3 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pdha2 Pck1 Pklr Acly Cs Pcx Pkm Me1 Pdha1 Clybl T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Vav3 Pak1 Vav1 Vav2 Pak3 Pak2 Nck2 Ppp3ca Nck1 Ptprc Ppp3cb Nfkbia Akt3 Akt2 Fos Grap2 Sos2 Sos1 Zap70 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Chuk Mapk1 Map3k1 Braf Pik3c3 Mapk3 Itpr1 Akt1 Rac1 Plcg1 Araf Mapk9 Prkcq Jun Mapk8 Nras Raf1 Pik3r1 Pik3r2 Pik3r3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Elk1 Map3k7 Mapk14 Map3k8 Map2k2 Ikbke Tbk1 Map2k1 Ticam2 Irak4 Ikbkb Ticam1 Chuk Ecsit Nfkbie Tollip Irak1 Tab1 Myd88 Tank Irf3 Tlr9 Tlr8 Tlr7 Tlr6 Tirap Tlr4 Tlr3 Mapk3 Tlr2 Nfkbia Mapk9 Jun Mapk8 Map2k3 Traf6 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 Pnpo Pdxk WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Ctnna3 Ctnna2 Csnk1d Ctnna1 Csnk1e Tle6 Bcl9 Csnk1g3 Hdac3 Csnk1g2 Hdac2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Smad1 Smad4 Ctnnb1 Ppp2cb Ppp2ca Smad5 Siah1a Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Nfatc4 Nfatc3 Nfatc2 Gng13 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Axin1 Arrb2 Arrb1 Hdac1 Ppp3ca Ppp3cb Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Crebbp Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Ep300 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Prkcq Cdhr1 Pcdha10 Prkcg Pcdha11 Prkch Pcdha12 Prkci Pcdh1 Cdh19 Prkcb Pcdh11x Cdh17 Cdh16 Prkcd Cdh15 Cdh13 Prkce Cdh12 Prkca Cdh11 Cdh10 Nfatc1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Prkcz Pcdhga1 Pcdhga2 Pcdhga3 Gsk3b Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Gng2 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Gnb1 Arid1a Fbxw11 Pygo2 Btrc Pygo1 Tle4 Tle3 Tle2 Tle1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Pnp Xdh Hprt1 Aprt Ada TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Cacna1e Cacna1a Gnat2 Adcy10 Cacna1b Stx1b Cacnb1 Stx1a Gng10 Grm3 Grm2 Gng3 Gng4 Gng7 Gng8 Gngt2 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Gnb5 Snap29 Prkar1a Snap25 Prkar1b Prkx Snap23 Prkacb Prkaca Gnao1 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gng11 Gnai3 UNTITLED%PANTHER PATHWAY%P05916 untitled Gng12 Pdyn Gng2 Gng10 Adcy2 Oprk1 Gnao1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Avp Gngt2 Oxt Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Dpysl2 Dpysl4 Plxnb1 Sema3a Sema4d Dpysl5 Cdk5 Rac2 Fes Crmp1 Dpys Frk Rac1 Rhoa Pak1 Arhgef1 Fyn Nrp1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Cacna1g Cacna1a Cacna1b Cnr1 Grm1 Grm5 Plcb3 Plcb2 Plcb1 Gnao1 Gng3 Gng4 Gng7 Gnb1 Gng8 Gngt2 Gnai1 Gnb2 Gnb4 Gng11 Gnb3 Gnai3 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Tbp Tbpl2 Tbpl1 Rrn3 Polr1b Taf1a Taf8 Taf1c Taf1b Polr1d Polr2k Cavin1 Ubtf Ttf1 Psmc3ip PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pnpo Pdxk SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Tk1 Cda Adat2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gnal Gng12 Prkx Prkacb Gng2 Adrb2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gnal Pdyn Creb1 Penk Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Gng2 Adcy2 Prkaca Oprd1 Gnao1 Oprm1 Adcy7 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gnai3 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Itpr1 Adra2c Adra2b Plcb4 Plcb3 Gna11 Adra1b Adra1a Prkcg Plcb2 Plcb1 Adra2a Prkcd Prkce Prkca Plce1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ace Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Pdha1 Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Plcg1 Ptk2b Prkca Prkcb P2ry2 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Cant1 Galt Slc35a2 Slc2a1 Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Mapk14 Cd40 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Dusp1 Cd40lg Nfkb1 Chuk Tnfaip3 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Plcb4 Itpka Miox Ptpmt1 Pi4ka Inpp4a Pikfyve Ipmk Impa1 Mtor Isyna1 Becn1 Vac14 Sacm1l Inpp1 Pik3cb Pik3r4 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpia CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ace Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Ugt3a2 Gpi Pgm1 Gusb Pgm2l1 Gys1 Gaa Agl Ugp2 Pygl Amy1 Ugdh LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Dlat Pck1 Dld CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Cyp2b10 Cyp2c65 Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2a5 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh D2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 Hk1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Mapk8 Shc1 Nfkbia Ptpn7 Map3k1 Cd3g Cd247 Elk1 Nfkb1 Map2k7 Cd3d Mapk3 Calm1 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Cbr1 Akr1c18 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Gls2 Glud1 Hal Sds Gldc Aqp8 Asns Asrgl1 Amt Cps1 Glul Dld TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Nfkbia Nfkb1 Mapk3 Prkcb Prkca Rela Itpr1 Plcb1 Map2k1 Raf1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 Abcc8 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Fig4 Cdipt Ambra1 Pip5k1a Pik3cd Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpe Prps1l1 Pgd Dera Pgls Pgm1 Rpia SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Odc1 Mat2b Mat2a Srm ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ace Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Pfkl Fbp1 Tpi1 Aldoa Gmppa Mpi Pmm1 Sord Akr1b1 Uxs1 Khk Pfkfb1 Gmds ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Nme1 Dctd Nt5c Slc28a3 Slc29a1 Ctps1 Slc28a1 Rrm1 Rrm2 Tyms Rrm2b Dck Cmpk1 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Kcnj11 Abcc9 Cacna2d2 Pdia2 Sdf2l1 Comt Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 Cyp3a16 Cyp2c50 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Nqo1 Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Cant1 Galt Slc35a2 Slc2a1 Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Tymp Dhodh Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Acads Acaa2 Echs1 Hsd17b10 Acat1 Hadh Acadl TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 Cyp3a16 Cyp2d22 Sult1a1 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Qars1 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Abcc10 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Cyp2b10 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat Aldh1a1 Cyp3a16 Cyp2a5 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 Phyh MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ace Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Tymp Dhodh Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Tyr Dct PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa Farsb Il4i1 Gstz1 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob Rpia Fbp2 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 Pgam2 Galm G6pc1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Pfkl Fbp1 Tpi1 Aldoa Gmppa Mpi Pmm1 Sord Akr1b1 Uxs1 Khk Pfkfb1 Gmds AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ace Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Fshr Prkacb Cga Gng12 Ppp1ca Gnb1 Adcy2 Creb1 Gngt1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Pnmt Th Ddc GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Cds2 Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp2b10 Ugt1a9 Slc22a1 Abcc2 Cyp3a16 Cyp2d22 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Mapk8 Shc1 Map3k1 Elk1 Mapk3 Calm1 Rac1 Ppp3ca Jun Ppp3cb Syk Fos Nfat5 Map2k1 Cd79b Lck Lyn Grb2 Orai1 Blnk Raf1 Hras Prkcb Plcg1 Prkca GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Chrm1 Htr2c Gnaq Gnb1 Plcb1 Tub Gngt1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Farsa Farsb Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ace Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 Bpgm Pgam1 G6pc1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 Abcb1a Sult1e1 Sult2a1 Abcg2 Abcc4 Abcc5 Abcc1 Ugt2b36 Gstt1 Cyp2d22 Sult1a1 Cyp3a16 Cyp2a5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Bckdhb Sds Pcca Bckdha Pccb Mmut Dbt Dld METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 Cbr1 Cyp2d22 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Cyp3a16 Ptgds Cyp2j6 Cyp4f3 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Abcc10 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhd Sdhc Sdhb Sdha Ndufa1 ATP6 mt-Co1 Uqcrc1 Atp5f1d Atp5f1c Atp5pb Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Nqo1 Ggcx Vkorc1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn1b Scn10a Cyp3a16 Cyp1a2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Spcs1 Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 Cps1 Asl Otc ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ace Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Pgm1 Gale Glb1 Lct Gla Hk1 Akr1b1 Galt Gaa Ugp2 B4galt1 G6pc1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Cyp3a16 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Inpp4a Ipmk Ippk Impa1 Bpnt1 Ip6k1 Isyna1 Inpp5j Itpk1 Inpp4b Nudt3 Minpp1 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acads Echs1 Acsm1 Hmgcl Oxct1 Acat1 Hadh CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Gls2 Ears2 Glud1 Gclc Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat Cps1 Glul Gad1 Gss Gsr BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Mvk Fdft1 Lss Sqle Pmvk Fdps Hmgcr Acat1 Idi1 Mvd BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpia PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Cdipt Cds1 Pla2g2d Ptdss1 Ptdss2 Gde1 Phospho1 Pld2 Plpp1 Pisd Pcyt1a Pla2g15 Lypla1 Ptpmt1 Chat Dgka Pemt Chka Agpat1 Gpd2 Pgs1 Gpam Gpd1 Crls1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfd C3 C5 C6 C9 Cfp C8a Cfb NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Slc6a4 Cyp3a16 Cyp2d22 Cyp2c50 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Cerk Sptlc2 Enpp1 Degs2 Gba1 Ugt8 Samd8 B4galt2 Sphk2 Ugcg Sdr16c5 Gla Acer2 Sptlc1 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Tyrp1 Cat Sod3 Sod2 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Bche Ces2h Ugt1a9 Ces1d Erp29 Top1 Ugt1a1 Hspa5 Cyp3a16 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 Serpinc1 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ace Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Glud1 Pkm Sdhd Hk1 Sdhc Sdhb Sdha Cs EG433182 Idh3g Mdh1 Pgd Mpc1 Fh Idh1 Idh3a Slc2a13 Cad Gapdhs Bpgm Aco1 Rpia Gpi H6pd Taldo1 Tktl1 Pfkm Bckdhb Pdhx Aldoc Gls Acly Ogdh Pgk2 Sucla2 Slc16a1 Ireb2 Gsr PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Cyp3a16 Abcc10 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Ghr Stat5a Hras Mapk1 Stat5b Rps6ka1 Ins2 Slc2a4 Sos1 Jak2 Shc1 Mapk3 Plcg1 Prkca Map2k1 Socs1 Grb2 Irs1 Insr Raf1 Ptpn6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Atp1a1 Atp1a3 Aqp3 Aqp2 Ca1 Atp6v1b1 Slc4a1 Scnn1a Scnn1b Scnn1g Atp1b1 Atp1b3 Atp1b2 Slc14a2 Atp1a2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd2 Gpd1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Dlat Pck1 Dld DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Ptpmt1 Pik3cd Prex1 Inpp5f Plce1 Inppl1 Zfyve16 Vac14 Pik3c3 Pik3r4 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Vars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Mapk8 Map3k1 Jun Faf1 Arhgdib Map3k7 Pak1 Prkdc Ripk2 Fasl Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Daxx Dffa Dffb ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcb1a Slco1b2 Abcg2 Abcc1 Tuba1b Abcc2 Tubb1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Mpc1 Pcx Aars2 Agxt Gpt HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Tpi1 Rpe Rpia G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ace Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 Serpinc1 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Pdia2 Ptgis Sdf2l1 Cyp2c65 Hyou1 Cyp2e1 Pdia6 Ephx2 Pdia4 Ptgs1 Ppib Alox12b Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Erp29 Cbr1 Ugt1a1 Hspa5 Ugt2b1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Ugt1a2 Cyp4f15 Cyp3a16 Ptgds Slc22a8 Cyp2j6 Cyp2c50 Cyp4f3 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Ca1 Slc22a2 Slc22a6 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Aqp1 Slc7a8 Slc7a9 Slc6a20a Slc4a4 Slc9a1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Epo Epor Stat5a Hras Sos1 Mapk8 Jak2 Shc1 Elk1 Mapk3 Plcg1 Jun Fos Map2k1 Grb2 Raf1 Ptpn6 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp3a16 Oprm1 Cyp2d22 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Dera Prps1 Gpi Pgls Pgm1 Pfkl G6pdx Fbp1 Tkt Aldob Rpe Rpia HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 Gss Gsr GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Sgpl1 Plpp1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla Sptlc1 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Aldh6a1 Aldh2 Abat Upb1 Dpys Aoc3 Cndp1 Dpyd Gad1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Cacna2d2 Cacna1a Slc2a2 Chrm3 Cacnb1 Prkca Gng2 Gnaq Gnb1 Adcy10 Vamp2 Plcb1 Rab3a Rapgef4 Glp1r Camkk1 Itpr3 Abcc8 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Prkacb Ppp1ca Gnb1 Creb1 Gngt1 Htr6 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp2b10 Grin1 Cyp2c65 Cyp3a13 Cyp3a16 Oprm1 Cyp2d22 Cyp2c50 Grin2a PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cth Mars1 Mettl6 Scly Ggt1 Mat2b Sephs2 Slc39a8 Papss1 Mat2a Cbs GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Prkacb Gnb1 Adcy2 Ptgdr Gngt1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gpi Hk1 Gbe1 Gys1 Ganab Hkdc1 Pgm2 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa Farsb Il4i1 Gstz1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Rock1 Lpar4 Srf Gng2 Gnb1 Itpr1 Plcb1 Akt1 Adcy1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Crat Abcd2 Pex13 Crot Pex11g Acsl1 Abcd1 Slc25a20 Pex14 Cpt2 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Sgpl1 Plpp1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla Sptlc1 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 Ugt2b38 Cyp19a1 Cyp17a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 Cps1 Asl Otc CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Abat Il4i1 Nars1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asns Asrgl1 Adsl Gad1 Asl CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Hras Mapk1 Prkca Nfkbia Rela Itpr1 Plcb1 Map2k1 Nfkb1 Prkcb Raf1 Mapk3 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Pnmt Aoc1 Got1 Hgd Acss1 Haao Mif Dbh Tyr Fah Comt Cyp2e1 Dct Cat Aldh1b1 Aldh2 Acss2 Gstz1 Aldh3a1 Maoa Ddc GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Stat5a Hras Mapk1 Stat5b Rps6ka1 Ins2 Slc2a4 Jak2 Shc1 Mapk3 Plcg1 Gh Prkca Map2k1 Grb2 Irs1 Raf1 Ptpn6 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Mpc1 Pcx Aars2 Agxt Gpt MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Pgm1 Gale Galk1 Gck Galt Uxs1 Ugp2 Ugdh PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Plcg1 Prkca Pik3cg Pik3r6 Plcb1 Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nqo1 Npr1 Nmnat1 Clock Nampt Ppargc1a Rora Sirt1 Nmnat3 Nmnat2 Nadk CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb Fech Uros Hmox1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Prkacb Ppp1ca Gnb1 Htr7 Creb1 Gngt1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 Cps1 Asl Otc GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Ptgs1 Pdia4 Ppib Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 Ugt1a2 Cyp3a16 Slc22a8 Cyp2c50 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Slc2a1 Pgam2 Galm Pgam1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Prkar1b Kcnh2 Chrm2 Prkar2a Kcnk1 Prkar2b Kcnq1 Atp1b4 Slc8a1 Mcu Adrb1 Atp1b1 Prkacb Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Slc9a1 Abcc8 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Cyp3a16 Cyp2c50 Grin2a KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna3 Cyp2b10 Ugt1a9 Fmo3 Chrnb2 Ugt1a5 Aox1 Chrna4 Cyp2a5 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Shmt1 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk Plpp1 Gpam Aldh3a1 Gpd1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Gls2 Ears2 Glud1 Gclc Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat Cps1 Glul Gad1 Gss Gsr XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 Slc29a2 Paics Slc28a2 Nt5c2 Ada GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme1 Nme2 Ak2 Ak1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 Slc29a2 Paics Slc28a2 Nt5c2 Ada CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Cth Cars1 Gclc Got1 Gclm Ldha Mpst Ctns Cdo1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Rasa1 Stat6 Srf Jak1 Egf Stat3 Sos1 Mapk8 Stat2 Shc1 Stat1 Map3k1 Elk1 Mapk3 Jun Fos Map2k1 Grb2 Raf1 Hras Prkcb Map2k4 Plcg1 Prkca Egfr FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Pfkl Fbp1 Tpi1 Aldoa Gmppa Mpi Pmm1 Sord Akr1b1 Uxs1 Khk Pfkfb1 Gmds BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cth Cbs VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Aox1 Pdxk Alpl Pdxp Pnpo NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Pgm1 Gale Hk1 Galt Uxs1 Ugp2 Galk2 Ugdh EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ace Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 Gss Gsr PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Mars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tymp Ces1d Cda Slc28a1 Tyms DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Enpp1 Tyr Flad1 Rfk Acp1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Pdia2 Slc6a4 Sdf2l1 Slc6a3 Hyou1 Adra1a Pdia6 Scn10a Pdia4 Pcsk2 Ppib Chrna4 Dnajb11 Oprm1 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Ugt2b36 Ugt2b1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Ugt1a2 Grin2a MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Acads Acaa2 Echs1 Hsd17b10 Acat1 Hadh Acadl ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 Cps1 Asl Otc PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Gnpat Cept1 Agps Agpat1 Plpp1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Chst11 Suox Sult2b1 Papss2 Bpnt1 Sult1a1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ace Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ugt1a9 Ptgs1 Cyp3a16 Ptgs2 Cyp2d22 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme1 Nme2 Ak2 Ak1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1b1 Atp1a1 Atp1b3 Atp1a3 Gck Atp1b2 Treh Slc2a2 Slc5a1 Atp1a2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Dlat Pck1 Dld HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Aox1 Slc6a4 Maob Cyp3a13 Maoa Cyp2d22 Cyp2c50 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Glud1 Slc1a4 Slc38a4 Slc2a4 Slc2a2 Gpt2 Slc25a22 Gpt GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Nme1 Dctd Nt5c Slc28a3 Slc29a1 Ctps1 Slc28a1 Rrm1 Rrm2 Tyms Rrm2b Dck Cmpk1 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Gls2 Glud1 Pkm Pcx Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Idh3g Pdha1 Suclg1 Mdh1 Pgd Pklr Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Ldha Dlst Pdhb Aldob Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl Taldo1 Pgk1 G6pdx Slc2a2 Tkt Slc1a5 Hk2 Slc16a1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Gls2 Glud1 Pkm Pcx Pfkp Sdhb Sdha Cs EG433182 Dhtkd1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Dlat Tktl2 Aco1 Pdha2 Dld Slc16a4 Slc1a2 Rpia Gpi Taldo1 Pgk1 G6pdx Hk2 Slc2a1 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Lbr Dhcr24 Ebp Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Tyk2 Mapk1 Jak1 Stat3 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Ces1d Oprm1 Bche Ces2h INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Ptpmt1 Cct3 Pik3ca Bpnt2 Ipmk Impa1 Isyna1 Becn1 Vac14 Synj1 Plcb4 Pik3c3 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Hras Pik3ca Vav3 Rala Ralbp1 Casp9 Pld1 Rhoa Ralgds Bad Elk1 Smad3 Bcl2l1 Smad4 Chuk Apaf1 Mapk3 Akt1 Foxo4 Rac1 Map2k1 Raf1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Agtr1a Gng2 Hsd3b6 Gnaq Gnb1 Cyp21a1 Cyp11b2 Cyp11a1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpe Prps1l1 Pgd Dera Pgls Pgm1 Rpia CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Pnmt Th Ddc ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Cth Cars1 Gclc Got1 Gclm Ldha Mpst Ctns Cdo1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itgb3 Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Rock1 Lpar5 Srf Gng2 Gnb1 Itpr1 Plcb1 Akt1 Adcy1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Cyp2b10 Cyp2c65 Aldh1a1 Cyp3a16 Aldh3a1 Cyp2a5 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Slc10a2 Gpbar1 Glp1r NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Hras Mapk1 Ins2 Slc2a4 Sos1 Mapk8 Shc1 Akt1 Pik3cg Irs2 Pik3r6 Map2k2 Pdpk1 Foxo1 Map2k1 Grb2 Irs1 Insr Raf1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Dlat Pck1 Dld PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Lars1 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Bpnt2 Ipmk Impa1 Isyna1 Ip6k1 Ppip5k1 Synj1 Nudt3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Crat Abcd2 Pex13 Crot Pex11g Acsl1 Abcd1 Slc25a20 Pex14 Cpt2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Impa1 Becn1 Vac14 Synj1 Plcd4 Pik3c3 Pik3r4 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itgb3 Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 Gss Gsr TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp2b10 Ephx1 Cyp2c65 Cyp3a13 Cyp3a16 Cyp2c50 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Rb1 Apaf1 Cdkn1a Pcna Ccne1 Ccnd1 Gadd45b METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C1qb C1qa C1rb Serping1 Masp2 C2 C4a C1s2 C1qc Mbl2 Cfd C3 C5 C6 C9 C8a Cfb MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma4 Ubc Psmc6 Psmc5 Psma3 Psma6 Psma5 Psmc2 Psmc1 Psmc4 Psma2 Psmc3 Psma1 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk Plpp1 Gpam Aldh3a1 Gpd1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Mapk8 Map3k1 Elk1 Map2k7 Calm1 Jun Map2k1 Grb2 Raf1 Hras Mapk1 Pld1 Gna11 Src Fshb Lhb Gnrh1 Prkcb Gnrhr Hbegf Camk2a Cga Adcy5 Prkca Cdc42 Egr1 Mmp14 Lrrc7 Erbb4 Mmp2 Actn4 Itpr1 Plcb1 Atf4 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Cyp2c65 Cyp2e1 Nat1 Cyp3a16 Cyp1a2 Xdh Cyp2a5 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Cyp3a16 Grin2a HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Pfkl Hk1 Fbp1 Tpi1 Aldoa Mpi Pmm1 Sord Akr1b1 Aldob Khk Pfkfb1 Gmds Gmppb Phpt1 Fcsk Fpgt Gfus BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Hk2 Pkm Pfkp EG433182 Slc2a1 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Cd79a Nfatc4 Nfatc1 Nfatc3 Nfatc2 Ppp3cc Sos1 Mapk8 Btk Shc1 Map3k1 Elk1 Mapk3 Rac1 Ppp3ca Jun Ppp3cb Syk Fos Map2k1 Cd79b Lyn Grb2 Orai1 Blnk Raf1 Hras Prkcb Plcg1 Prkca LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Rock1 Srf Gng2 Gnb1 Lpar1 Itpr1 Plcb1 Akt1 Adcy1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Hmgcl Bdh1 Oxct1 Acat1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Abat Il4i1 Nars1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asns Asrgl1 Adsl Gad1 Asl LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Top2a Mpo Cyp3a16 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Cept1 Pemt Chka Pcyt2 Pisd Pcyt1a HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Cct3 Ambra1 Pik3ca Plcd1 Itpka Miox Ptpmt1 Pi4ka Impa1 Isyna1 Becn1 Synj1 Itpk1 Vac14 Sacm1l Inpp1 Minpp1 Pik3r4 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Dffa Cad Top2a Casp7 Casp3 Gzmb Hmgb2 Endog GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itgb3 Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkacb Prkar1a Gnb1 Prkaca Adcy10 Prkar1b Prkar2a Prkar2b Gngt1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Kars1 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Dera Prps1 Gpi Pgm1 Taldo1 G6pdx Pfkp Fbp1 Rbks Tktl2 Rpe Rpia TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 Hk1 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1qb C3 C1qa C1rb C5 C6 C9 C2 C4a C8a C1s2 C1qc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Gpi Pkm Pfkm Tpi1 Slc2a2 Aldob EG433182 Pgam2 Bpgm Galm Pgam1 G6pc1 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Fbp1 Hk1 Sord Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 Abcc8 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 Hk1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Enpp1 Pnp Nudt12 Nnmt Nmrk1 Qprt Nampt Bst1 Nnt Aox1 Nadsyn1 Nmnat2 Nt5c2 Nadk SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb Fech Uros Hmox1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb Fech Uros Hmox1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Gpi Pfkfb2 Hk1 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b Cyp3a16 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Slc22a1 Stat5a Abcb1a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Wars1 Tdo2 Kynu Cyp1a1 Haao Acmsd Ido1 Cat Aldh2 Afmid Aanat Tph1 Kmo Aadat Inmt Ddc Wars2 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Traf6 Pfkp Sdhd Slc25a1 Ikbkg Sdhc Sdhb Myd88 Nfkbia Sdha Ly96 Cs Cd14 Tirap Nfkb1 Tlr4 Chuk Acaca Mdh1 Acly Me1 Rela HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Fshr Prkacb Gng12 Gnb1 Adcy2 Avpr2 Gngt1 COAGULATION%SMPDB%SMP0000586 Coagulation Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Aldh1b1 Aldh2 Acss1 Acss2 Cyp2e1 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk Plpp1 Gpam Aldh3a1 Gpd1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Gars1 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Pgm1 Gale Glb1 Lct Gla Hk1 Akr1b1 Galt Gaa Ugp2 B4galt1 G6pc1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Lbr Dhcr24 Ebp Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa Farsb Il4i1 Gstz1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcb1a Slco1b2 Abcg2 Abcc1 Tuba1b Abcc2 Tubb1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nqo1 Nmnat1 Nampt Trp53 Sirt1 Nmnat3 Nmnat2 Nadk Aifm2 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Gls2 Glud1 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Ldha Dlst Slc7a7 Pdhb Me1 Idh3b Aco2 Dlat Dld Got2 Mycbp Slc38a5 Slc1a5 Slc1a4 Acly Slc16a1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Tpi1 Rpe Rpia KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Slc12a6 Slc12a1 Atp1a2 Clcnkb FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 Cps1 Asl Otc AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Pnmt Th Ddc SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Hras Mapk1 Nfkbia Nfkb1 Mapk3 Gngt1 Plcg1 Cxcl12 Ptk2b Pxn Crk Pik3c2g Ptk2 Bcar1 Gnaq Cxcr4 Gnb1 Gnai1 Map2k1 Raf1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agtr1a Ace Agt DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Maob Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Aox1 Cyp2c50 Maoa Grin2a TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Gls2 Ears2 Glud1 Gclc Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat Cps1 Glul Gad1 Gss Gsr WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Aldoc Pfkm Hk1 Tpi1 Aldob Fbp2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Kcnj11 Abcc9 Cacna2d2 Cyp1a2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Cyp3a16 Kcnj2 Dlg1 Abcc8 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Mpc1 Pcx Aars2 Agxt Gpt TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Ikbkb Cradd Mapk14 Traf2 Mapk8 Ikbkg Nfkbia Map3k1 Nfkb1 Map2k7 Chuk Map2k4 Jun Casp2 Ripk1 Tank Tnf Map2k6 Map4k2 Map2k3 Tradd TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 Phyh LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Prkca Pik3r6 Plcb1 Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Acaa2 Cpt1a Acsl1 Slc25a20 Echs1 Hadha Hadhb Hadh Acadl Cpt2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Nudt4 Inpp4a Ip6k2 Ipmk Impa1 Isyna1 Ppip5k1 Inpp1 Itpka 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Gpi Pcx Pank3 Fbp1 Tpi1 Slc2a2 EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Aldob Bpgm Pck1 Pgam1 G6pc1 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Kcnd2 Cyp2b10 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Ugt1a9 Ugt1a5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Chrna3 Atp1b1 Fmo3 Cacnb1 Atp1b3 Atp1b2 Aox1 Grin2a Cyp2a5 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb Fech Uros Hmox1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Sgpl1 Plpp1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla Sptlc1 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 Aldh3a1 Maoa PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Iars1 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Mdh2 Slc25a11 Got2 Slc25a12 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Tymp Dhodh Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Gnmt Mat2a Chdh Dmgdh Shmt2 Sardh Bhmt Slc44a1 Slc44a2 Mtr Shmt1 Mat2b Aldh7a1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C3 C5 C6 C9 Masp2 C2 C4a C8a Mbl2 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Fasn Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tymp Ces1d Cda Slc28a1 Tyms L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rars1 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Aldh6a1 Aldh2 Abat Upb1 Dpys Aoc3 Cndp1 Dpyd Gad1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Top2a Mpo Cyp3a16 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Mpc1 Pcx Acly Me1 Pdhb Slc25a11 Pdha1 Mdh1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Cyp2b10 Abcb1a Pon1 P2ry12 Cyp3a16 Cyp2c50 Cyp1a2 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 Abcc8 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Gls2 Ears2 Glud1 Gclc Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat Cps1 Glul Gad1 Gss Gsr ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Kcnj11 Abcc9 Cacna2d2 Adra1a Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Acaa2 Echs1 Mecr Ppt1 Hadha Hsd17b10 Hadhb THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Tymp Dhodh Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Mapk14 Sos1 Mapk8 Btk Map2k7 Gab2 Fyn Rac1 Syk Il13 Pla2g4a Fcer1a Map2k1 Il4 Il5 Lyn Grb2 Kras Pdk1 Raf1 Ms4a2 Pik3r1 Nras Lat Fcer1g Hras Mapk1 Csf2 Pik3ca Lcp2 Vav3 Akt1 Map2k4 Plcg1 Prkca Map2k2 Inpp5d Tnf Map2k6 Map2k3 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob Rpia Fbp2 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Gpi Taldo1 Prps2 G6pdx Pfkp Fbp1 Rbks Rpe Dera Pgls Pgm1 Tktl2 Rpia SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Ikbkb Mapk1 Prkca Nos3 Ikbkg Plcb1 Nfkb1 Creb1 Mapk3 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Spcs1 Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Abat Il4i1 Nars1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asns Asrgl1 Adsl Gad1 Asl ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Csad Ggt6 Ado Gad1 Cdo1 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 Slc29a2 Paics Slc28a2 Nt5c2 Ada PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpia QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Hoxb9 Rb1 Btg2 Trp53 Btg1 Prmt1 Ngf Fgf1 Ccnd1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 Abcc8 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1b1 Nos3 Trpv4 Prkg2 Prkg1 Gucy1a1 Trpc7 Kcnq5 Trpc4 Gucy1a2 Kcnq4 Kcnq3 Trpc3 Adcy10 Kcnq2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Nme1 Slc22a1 Nt5c Pgk1 Abcb1a Abcg2 Abcc4 Abcc1 Abcc2 Slc22a2 Pcyt2 Pcyt1a Sult1a1 Abcc3 Slc22a3 Chpt1 Dck Cmpk1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Abcb1a Slc6a2 Slc6a4 Cyp3a16 Cyp2d22 Cyp2c50 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Pgm1 Gale Galk1 Gck Galt Uxs1 Ugp2 Ugdh ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b Cyp3a16 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 Hk1 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Gls2 Ears2 Glud1 Gclc Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat Cps1 Glul Gad1 Gss Gsr ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Pnp Slc2a4 Slc2a1 As3mt Gsto1 Aqp9 Aqp7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa Farsb Il4i1 Gstz1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Impa1 Isyna1 Ip6k1 Ppip5k1 Itpk1 Synj1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Sars1 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Rock1 Srf Gng2 Gnb1 Itpr1 Plcb1 Akt1 Adcy1 Lpar2 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Galm Slc2a13 Aldob Pgk2 Gapdhs Bpgm G6pc3 Pgam1 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Gcg Cacnb1 Cacna2d2 Cacna1a Scn5a Slc2a2 Snta1 Sntb2 Sntb1 Abcc8 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Pfkl Hk1 Fbp1 Tpi1 Aldoa Mpi Pmm1 Sord Akr1b1 Aldob Khk Pfkfb1 Gmds Gmppb Phpt1 Fcsk Fpgt Gfus BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Crat Abcd2 Pex13 Crot Pex11g Acsl1 Abcd1 Slc25a20 Pex14 Cpt2 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Ptgir Prkacb Myl3 Mylk Gnb1 Adcy2 Gngt1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Traf6 Ecsit Irak1 Mapk8 Ikbkg Tollip Nfkbia Tlr1 Map3k1 Tlr9 Tab3 Tlr8 Nfkb1 Tlr7 Tab2 Chuk Tab1 Tlr6 Tlr5 Tlr3 Tlr2 Rela Map3k7 Myd88 Ly96 Cd14 Tirap Tlr4 Map2k4 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Bche Ces2h Ugt1a9 Ces1d Erp29 Top1 Ugt1a1 Hspa5 Cyp3a16 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob Rpia Fbp2 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Vnn1 Enpp1 Ppcs Ppcdc Coasy Pank1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpe Prps1l1 Pgd Dera Pgls Pgm1 Rpia TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ace Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Elk1 Nfkb1 Bad Map2k7 Chuk Jun Atf2 Arhgef7 Adora2a Braf Map3k4 Nfkb2 Prkcz Rap1a Pak1 Pard6a Rapgef3 Rapgef2 Hras Mapk11 Mapk1 Pik3ca Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 Map2k6 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr Slc46a1 Mthfd1l Mtfmt Mthfsl Aldh1l1 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Acaa2 Echs1 Mecr Ppt1 Hadha Hsd17b10 Hadhb ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Tars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Glud1 Pkm Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Suclg1 Mdh1 Pklr Mpc1 Fh Idh1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl Taldo1 Pgk1 Slc1a3 G6pdx Tkt Hk2 Gls Slc16a1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Pgm1 Gale Galk1 Gck Galt Uxs1 Ugp2 Ugdh PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 Tubb1 Cdkn1a Cyp3a16 Abcc10 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Kcnj11 Abcc9 Cacna2d2 Adra1a Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ace Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt11 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 Aldh3a1 Maoa CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Pde4d Cyp3a16 Cyp2c50 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Acadm Acaa2 Slc25a20 Echs1 Acsm1 Hadha Hadhb Hadh ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Chst11 Suox Sult2b1 Papss2 Bpnt1 Sult1a1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Akr1d1 Srd5a1 Hsd17b3 Pdia2 Sdf2l1 Akr1c6 Hyou1 Cyp19a1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp11b1 Hsd11b1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Cyp2b10 Cyp2c65 Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2a5 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Pdha1 Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Flt1 Vegfa Kdr NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Pdia2 Sdf2l1 Ugt2b36 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Oprm1 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 Ugt1a2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob Rpia Fbp2 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Cyp3a16 Grin2a PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Cept1 Chka Ptdss1 Pcyt2 Pisd METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Yars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Galm Slc2a13 Aldob Pgk2 Gapdhs Bpgm G6pc3 Pgam1 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Fig4 Ambra1 Pik3ca Itpka Miox Ptpmt1 Pi4ka Plcd3 Inpp4a Pikfyve Ipmk Ippk Impa1 Isyna1 Becn1 Itpk1 Vac14 Inpp1 Minpp1 Pik3c3 Pik3r4 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Cyp2b10 Ehhadh Acadsb Acsm1 Hadha Hsd17b10 Hadhb Ugt1a2 Ivd Cyp2a5 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Dars1 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 Atp1a2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ace Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Scn5a Snta1 Sntb2 Sntb1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Cyp2b10 Ugt1a9 Aldh1a1 Cyp3a16 Abcc10 Cyp2d22 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Mylk Vav3 Ralbp1 Pld1 Map3k1 Rac1 Cap1 Wasf1 Ccnd3 Cfl1 Ppp1r12b Actb Cdk5 Limk1 Cdkn1a Pcna Myl2 Arfip2 Ccnd1 Pak1 Pdgfra D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cth Cbs KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 Bpgm Pgam1 G6pc1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Sgpl1 Plpp1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla Sptlc1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 Hk1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Ikbkb Tnfrsf1a Ncoa3 Camkk2 Il1a Traf6 Il1r1 Irak1 Map3k14 Ikbkg Nfkbia Map3k1 Nfkb1 Chuk Tab1 Ubc Rela Map3k7 Camkk1 Myd88 Tlr4 Fadd Ripk1 Tnf Tnfrsf1b Tradd METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Kcnd2 Cyp2b10 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Cyp2c65 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Cyp3a16 Cyp2c50 Grin2a BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Atp4a Sstr4 Atp4b Ca1 Chrm3 Sst Cckbr Hrh2 Gast WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Glud1 Pkm Pcx Sdhc Sdhb Cs EG433182 Pgam2 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Aldob Idh3b Aco2 Aco1 Dld Rpia Gpi Pfkl Pgk1 G6pdx Slc2a2 Tkt Slc1a5 Pdhx Ogdh Slc16a1 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 Gss Gsr KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Sgpl1 Plpp1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla Sptlc1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb Fech Uros Hmox1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 Ugt2b38 Cyp19a1 Cyp17a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Ahcy Mtr Pemt Mat2b Mat2a Chdh Aldh7a1 Bhmt BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Spcs1 Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ace Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl18 Cars1 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Crk Skp2 Cdkn1b Mtor Trp53 Grb2 Pik3r1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Mpc1 Pcx Aars2 Agxt Gpt CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Ces1d Ugt1a9 Abcb1a Slco1b2 Abcg2 Cyp2c65 Abcc2 Cyp3a16 Impdh1 Ces2h RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Cyp2b10 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat Aldh1a1 Cyp3a16 Cyp2a5 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct Gstz1 Aldh3a1 Maoa Ddc CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway Cyp2b10 Abcb1a Pon1 P2ry12 Cyp3a16 Cyp2c50 Cyp1a2 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Nox3 Duox2 Slc5a5 Duox1 Tpo Tg Cyba Cybb Nox4 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Pfkl Fbp1 Tpi1 Pmm2 Tgds Mpi Amigo3 Sord Akr1b1 Aldob Khk Pfkfb1 Phpt1 Fcsk Fpgt Gfus INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Elk1 Nfkb1 Bad Map2k7 Chuk Jun Atf2 Adora2b Arhgef7 Braf Map3k4 Nfkb2 Prkcz Rap1a Pak1 Pard6a Rapgef3 Rapgef2 Hras Mapk11 Mapk1 Pik3ca Adcy2 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 Map2k6 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 Bpgm Pgam1 G6pc1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Cacnb1 Cacna2d2 Cacna1a Slc2a2 Sst Abcc8 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Ins2 Akt1 Pik3cg Irs2 Pik3r6 Tsc2 Mtor Eif4ebp1 Slc7a5 Tsc1 Eif4e Irs1 Insr HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Hmgcl Bdh1 Oxct1 Acat1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Hif1a Tlr4 Il1b Sirt3 Nlrp3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Ugt1a9 Cyp3a16 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Dlat Pck1 Dld REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Oprk1 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Htr4 Prkacb Ppp1ca Gnb1 Creb1 Gngt1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Sult1e1 Pdia2 Sdf2l1 Hsd17b1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Mapk14 Cacna2d2 Sos1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Cacna1f Cacna1c Cacna1d Map3k2 Hras Mapk1 Cacna1s Pld1 Gna11 Src Fshb Lhb Gnrh1 Prkcb Gnrhr Adcy1 Hbegf Camk2a Cga Cacnb1 Prkca Egr1 Mmp14 Lrrc7 Mmp2 Prkaca Actn4 Itpr1 Plcb1 Atf4 Map2k3 Egfr TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Cct3 Ambra1 Plcd1 Itpka Miox Ptpmt1 Inpp4a Ipmk Ippk Impa1 Bpnt1 Isyna1 Inpp5j Becn1 Itpk1 Vac14 Sacm1l Minpp1 Pik3c3 Pik3r4 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 Hadha Hadhb Gcdh Acadl Cpt2 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Ikbkb Mapk14 Traf6 Ecsit Irak1 Mapk8 Ikbkg Tollip Nfkbia Map3k1 Tlr9 Elk1 Nfkb1 Tlr7 Tab2 Chuk Tab1 Tlr3 Tlr2 Jun Fos Rela Map3k7 Eif2ak2 Ppara Myd88 Ly96 Cd14 Tirap Tlr4 Map2k4 Map2k6 Map2k3 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Cds2 Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Nfatc4 Nfatc1 Nfatc3 Nfatc2 Ppp3cc Sos1 Mapk8 Shc1 Nfkbia Ptpn7 Map3k1 Cd3g Cd247 Elk1 Nfkb1 Cd3d Mapk3 Ubc Fyn Rac1 Pik3cg Ppp3ca Jun Ppp3cb Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Pik3ca Zap70 Cd3e Prkcb Map2k4 Plcg1 Prkca MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Slc28a3 Slc29a1 Abcc4 Abcc5 Xdh Gmps Rac1 Hprt1 Aox1 Adk Ppat Tpmt Slc29a2 Slc28a2 Impdh1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Plcg1 Ptk2b Prkca Prkcb P2ry2 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Tymp Dhodh Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 Nt5c2 Tyms Gda Rrm2b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Aldh2 Prkacb Prkca Ppp3ca Dlg4 Grin1 Itpr1 Nos1 Xdh Grin2a METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Glud1 Pkm Pcx Pfkp Sdhd Hk1 Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Dlat Tktl2 Aco1 Dld Slc16a4 Rpia Gpi Taldo1 Pgk1 G6pdx Gls Slc2a1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Aox1 Pdxk Alpl Pdxp Pnpo PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Gls2 Ears2 Glud1 Gclc Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat Cps1 Glul Gad1 Gss Gsr JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Fig4 Cdipt Ambra1 Pip5k1a Pik3cd Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Cyp3a16 Cyp2c50 Grin2a APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Cth Cars1 Gclc Got1 Gclm Ldha Mpst Ctns Cdo1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Slc10a2 Gpbar1 Abcc4 Nr1h4 Slco1a4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Crat Abcd2 Pex13 Aldh2 Hacl1 Acsl1 Abcd1 Slc25a20 Pex14 Phyh Cpt2 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 Serpinc1 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Gpi Fbp1 Tpi1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 Pck1 G6pc1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Cant1 Galt Slc35a2 Slc2a1 Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 Grin2a GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Cyp2b10 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Cyp3a16 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Hagh Akr1b1 Pdhb Me1 Acyp1 Acot12 Dlat Pck1 Dld TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Sgpl1 Plpp1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla Sptlc1 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Akr1d1 Hsd3b6 Cyp11b1 Cyp21a1 Akr1c6 Hsd3b1 Cyp11b2 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm Amt Dld Maoa GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 Pgam2 Galm G6pc1 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Prkacb Pomc Gnb1 Mc2r Gngt1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 Hk1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Cyp2b10 Cyp2c65 Aldh1a1 Cyp3a16 Aldh3a1 Cyp2a5 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Prkacb Prkca Ppp3ca Dlg4 Grin1 Nos1 Grin2a Calm1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Hsp90aa1 Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Rasa1 Stat5a Hras Srf Egf Stat3 Mapk8 Jak2 Shc1 Map3k1 Elk1 Map2k7 Mapk3 Prkcb Plcg1 Prkca Jun Erbb4 Fos Map2k1 Grb2 Raf1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Rock1 Srf Gng2 Gnb1 Lpar6 Akt1 Adcy1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Pfkl Hk1 Fbp1 Tpi1 Aldoa Mpi Pmm1 Sord Akr1b1 Aldob Khk Pfkfb1 Gmds Gmppb Phpt1 Fcsk Fpgt Gfus GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 Hk1 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 Pgam2 Galm G6pc1 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Glud1 Got1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 P4ha3 Cps1 Nos1 Ckb Asl Otc BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 Gss Gsr CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Aldoc Pfkm Hk1 Tpi1 Aldob Fbp2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Hars1 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpe Prps1l1 Pgd Dera Pgls Pgm1 Rpia DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d22 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Prkacb Cga Ppp1ca Gnb1 Adcy2 Lhb Lhcgr Creb1 Gngt1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 Atp1a2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Gpi Pcx Fbp1 Tpi1 Slc2a2 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Mpc1 Pgm1 Hk2 Ldha Pank1 Slc37a4 Bpgm Pck1 Pgam1 G6pc1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk Plpp1 Gpam Aldh3a1 Gpd1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Prps1 Gpi Pfkl Taldo1 G6pdx Fbp1 Tkt Aldoa Rbks Rpia SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Gpi Mgam Gbe1 Gys2 Pgm2l1 Sis Agl Pygl Ugdh Amy2a5 Pgm1 Hk2 Gusb Gck Ugp2 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Agpat1 Dgat1 Gpam Gpd1 Lpin1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cth Cbs HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Agtr1a Gng2 Gnaq Gnb1 Ace Agt CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Aldh6a1 Aldh2 Abat Upb1 Dpys Aoc3 Cndp1 Dpyd Gad1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugt2b1 Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 Agl Ugp2 Pygl Ugdh 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Acmsd Dlst Dhtkd1 Dld Aldh8a1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Wars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Itpka Inpp4a Ipmk Ippk Impa1 Ip6k1 Isyna1 Ppip5k1 Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F11 F13a1 Plat Plg Klkb1 F2 Serpinc1 F3 F5 F7 F8 F9 Ggcx F13b Vkorc1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Aass Echs1 Dhtkd1 Acat1 Hadh Dlst Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Gng2 Gnaq Gnb1 Itpr1 Plcb1 Nfkb1 Prkcb MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca Dld Hibch Ldhal6b AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 Ugt2b38 Cyp19a1 Cyp17a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Atp1a1 Atp1a3 Atp4a Atp4b Aqp3 Aqp2 Slc8a1 Trpv5 Atp1b1 Atp1b3 Atp1b2 Slc12a3 Atp1a2 Clcnkb ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 Cps1 Asl Otc FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Kcnj11 Abcc9 Cacna2d2 Cacna1g Ryr2 Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Mapk8 Map2k7 Gab2 Fyn Rac1 Syk Il13 Fcer1a Map2k1 Il4 Lck Lyn Grb2 Kras Blnk Raf1 Ms4a2 Pik3r1 Nras Lat Hras Mapk1 Csf2 Akt1 Plcg1 Prkca Map2k2 Inpp5d Tnf SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Mapk11 Mapk1 Nos3 Ikbkg Nfkb1 Ptgs1 Chuk Creb1 Mapk3 Sucnr1 Prkca Plcb1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 Cyp3a16 Cyp2d22 Sult1a1 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 Paics Nt5c2 Ada D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Arhgap5 Parp1 Casp1 Jun Prf1 Arhgap32 Casp9 Casp8 Casp3 Arhgdib Apaf1 Gzmb FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Aldoc Pfkm Hk1 Tpi1 Aldob Fbp2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 Gss Gsr ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Prxl2b Alox12 Cyp2u1 Alox5 Akr1c18 Lta4h Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Nars1 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Galm Slc2a13 Aldob Pgk2 Gapdhs Bpgm G6pc3 Pgam1 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Prkacb Ppp1ca Gnb1 Adcy2 Hrh2 Creb1 Gngt1 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 Fdps Idi1 Hsd17b7 Nsdhl LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gng2 Lpar3 Gnb1 Itpr1 Plcb1 Akt1 Adcy1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Gls2 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors Pias3 Ar Nr3c1 Vdr Rara SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis Hadha Gpcpd1 Ptpmt1 Ptdss2 Slc44a2 Pitpnb Cpne1 Pnpla3 Cpne3 Lpcat4 Pla1a Phospho1 Pgs1 Abhd3 Cpne6 Plaat3 Pla2g3 Mgll Csnk2b Gpat4 Etnk1 Chpt1 Gpat2 Lpin1 Stard10 Dgat2 Mboat7 Chkb Crls1 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling Egfr REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Ajuba Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Ccnb2 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Btrc Nedd1 Actr1a BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix Col15a1 Capn15 Col17a1 Col18a1 Ctsg Col12a1 Klkb1 Plg Adam17 Cma1 Mmp20 Capn9 Adamts1 Mmp12 Scube1 Mmp7 Casp3 Mmp17 Capn7 Mmp19 Prss2 Mmp9 Tmprss6 Mmp1a Bmp1 Spock3 Tll1 Capn10 Mmp10 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression Ajuba H2ax Med23 Sap30l Med24 Plin2 Akap8l Phf20 Morc2a Hdac1 Cxxc1 Scd1 H2bu2 Men1 Sap30 Yeats2 Aebp2 Ccnc Zfp141 Hcfc1 Med16 Med17 Sap30bp Taf1d Kansl2 Mphosph8 Zfp454 Znf382 Polr2k Epop Elovl5 Setd1b Ncoa6 Gtf2h2 Cidec Gtf2h3 Gtf2h5 Sap130 H2bc9 H2bc7 H2bc8 Fabp4 Bod1 Tada2a Med31 Ercc3 Rbbp7 Ppargc1b Phf19 Phlda1 Cdk8 Cdk5 Zfp324 Ubtf Mybbp1a Psip1 Gatad2a Ezh2 H3c7 Mgll Lpin1 Dgat2 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides Bpifb2 Bpifa1 Pdzd11 Rnase2b Prtn3 Pglyrp2 Art1 Defb23 Reg3g S100a9 Atox1 Chga Ctsg SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis Psmb1 Psmc2 Msgn1 Ctnnb1 Psma7 Dll3 Psmd12 Epha4 Psmd11 Psma6 Psmd8 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism Pdzd11 Slc5a6 Btd Pcx Acacb SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport Slc44a2 Slc10a6 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements Psmb1 Psmc2 Psma7 Exosc9 Dcp2 Exosc8 Mapk14 Zfp36 Exosc4 Pabpc1 Dis3 Exosc6 Exosc1 Exosc2 Tnfsf13 Akt1 Psmd12 Psmd11 Psma6 Psmd8 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state Psmb1 Ift122 Psmc2 Psma7 Btrc Ift52 Prkar2a Prkar1a Fuz Psmd12 Prkacb Rbx1 Psmd11 Psma6 Ift140 Psmd8 Itch MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 Fkrp Slc35a4 Slc35a1 Crppa Large2 Fktn ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2bu2 Rbbp7 H2ax H2bc9 H2bc7 H2bc8 Gatad2a Hdac1 H3c7 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs Psmb1 Psmc2 Psma7 Rasa4 Nf1 Dab2ip Spred1 Rasal3 Spred3 Spred2 Psmd12 Rbx1 Psmd11 Psma6 Psmd8 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation Cfd Cfb HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle Chmp6 Pdcd6ip Ssrp1 Nup133 Xrcc4 Taf7 Nmt1 Taf5 Taf2 Polr2k Gtf2h2 Gtf2h3 Gtf2h5 Ercc3 Psip1 Ell Polr2g Ubap1 Nup205 Nup107 Tsg101 Sec13 Taf11 Mvb12a Taf13 Taf12 Rcc1 Gtf2f1 Nup85 Chmp3 Nup88 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation Hexb Cspg5 Hyal3 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes Uba7 Rigi RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling Ap2a2 Ap2a1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade Ppp2r5e Frat2 Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib Cdc37 Erbin PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 Phb1 Pmpcb Spg7 Phb2 Micu1 Mcu Parl KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development Jag1 Hoxd11 Eya1 Hnf4a Ctnnb1 Hoxb4 Hoxa6 Lhx1 Gdnf Pax8 Six2 Id4 Hoxa11 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK Alk Mdk Irs1 Hdac1 Frs2 Pik3r1 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat Ell Polr2k Ercc3 Polr2g Ssrp1 Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs Cdh11 Tnrc6a RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF Brd2 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins Cyp2d22 Cyp2c65 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants Cdc37 Erbin NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Kctd1 Kctd15 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX Tnrc6a Ctnnb1 Ube2c Fzr1 Anapc11 Anapc10 Cdkn2a Anapc1 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection Tufm Edem2 Tbk1 Akt3 Akt2 Jak1 St6galnac3 Iscu Tyk2 Vps33a Vps33b Stt3b Ano6 St6gal1 Ifna16 Tlr7 Zdhhc3 Pik3r4 Ganab Rpn2 Sdc3 Zdhhc9 Rpn1 Akt1 Vps11 Ube2v1 Nod1 Pals1 Vps16 Golga7 Ripk2 Sftpd Ptpn11 Gpc3 Gpc2 Magt1 Gpc4 Rps25 Rps26 St3gal4 Rps27 Mgat4a Mgat4b St3gal1 Irak1 Il17f Rps21 Il17a Srpk1 Gemin2 Tmem258 Tab2 Nup205 Ddx20 Nup107 H2-Q10 Sec13 Nup85 Chmp3 Nup88 Chmp6 Nup133 Rigi Mgat5 Dad1 Rps11 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome Ercc3 Ssrp1 Taf7 Taf5 Taf2 Ell Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels Atp2b2 Atp2b1 Slc8a1 Slc8a2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors Chrnb2 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding Tuba1a Tubal3 Gng3 Gnb2 Xrn2 Gnb1 Sphk1 Pdcl Gnb4 Cct7 Csnk2b Ccne1 Kif13a Tubb2a Gna14 Ap3m1 Fbxw4 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins H2bu2 Rbbp7 Zfp141 Zfp324 Gatad2a Zfp454 H3c7 Znf382 H2ax H2bc9 H2bc7 H2bc8 Hdac1 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing H2bu2 St3gal4 St3gal6 Jun Mamld1 Elf3 Notch3 E2f3 H3c7 Tfdp2 Tfdp1 Tnrc6a H2ax H2bc9 H2bc7 H2bc8 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 Stap2 Ptk6 Dock1 Cbl Rhoa Dok1 Sfpq Akt1 Epas1 Crk Ccne1 Nr3c1 Egfr SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism Pdzd11 Slc5a6 Pank4 Ppcs Fasn Enpp2 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion Acsl3 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript Dhx38 Thoc1 Thoc3 Nup205 Nup133 U2af1l4 Nup107 Thoc6 Sec13 Nup85 Ddx39b Nup88 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels Trpc6 Trpv4 Trpv6 Trpm8 Trpm4 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation Tnfrsf10b Fas Traf2 Ripk1 Tlr4 Ly96 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation Psmb1 Cdc34 Psmc2 Tab2 Psma7 Btrc Ube2v1 Psmd12 Psmd11 Psma6 Psmd8 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 Bdnf Cdk5 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization Ptk6 Egfr DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Gck Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA Gins2 Gins1 Mcm8 Cdc45 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer Tgfbr1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation Rap1a Map2k2 Map2k1 Mapk1 Frs2 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling Frs2 Ptpn11 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly Apoc1 Mttp Apob REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase Psmb1 Psmc2 Psma7 Ube2c Btrc Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism Rpl4 Mecr Glce Chsy3 Rpl39 Eno2 Rpl7 Gls Gstk1 Hacd1 Hmbs Entpd4 Entpd8 Afmid Pdxk Ndst3 Med8 Plcg2 Bpnt1 Glyatl3 Sco1 Rpl22 Ranbp9 Slc25a51 Ido2 Pip4k2c As3mt Tph1 Higd1c Plch2 Gns Abo Oaz2 Adh4 Itpk1 Slc19a1 Lgmn Ogdh Hao2 Ugt8 Pik3c2b Clps Tcn2 Ephx1 Mtmr7 Higd2a Mtmr6 Mtmr4 Ppt1 Uck2 Ada Plcb4 Gpi Miox Mfsd2b Slc27a1 L2hgdh Asah1 Slc25a27 Sgms2 Ecsit Akr1b1 Cyp7b1 Med28 Ptgr2 Agmat Slc25a21 Arg2 Itpkb Man2b1 Coq8a Chst2 Acot3 Aacs Acot9 Mtf1 Aldh1l1 Slc25a17 Slc25a18 Pik3r5 Tkt Cyp7a1 Slc25a10 Smpd1 Kcnb1 Plcd1 Rpl18 Gnmt Gatm Vkorc1l1 Ormdl1 EG433182 Has3 Hsd11b1 Sult1e1 Pygb Mdh1 Ckm Mdh2 Agl Mogat1 Pygl Pygm Lyrm4 Fmo2 Sephs2 Hs6st2 Lyrm2 Ciao2b Mcee Tmem186 Hacl1 Ip6k2 Ip6k3 Hsd17b10 Cyp4f14 Cox6a1 Cox6a2 Hsd17b14 Mpc2 Sc5d Slc37a4 Abhd5 Fitm1 Serinc4 Serinc2 Crat Serinc3 Chp1 Tnfaip8l1 Pipox Carns1 Gstt1 Inpp5f Slc26a2 Inpp5b ATP6 Ffar1 Cemip Fam20b Mtm1 Acly Elovl1 Hpse Elovl6 Nmral1 Coa3 Ndor1 Synj1 M6pr Secisbp2 G6pc1 Kcng2 Me1 Slc27a5 Gadl1 Urod Aco1 Slc23a1 Slc46a1 Thrap3 Slc35b3 Slc23a2 Aldh7a1 Fhl2 Cers6 Inmt Cers3 Cers2 Cers1 Spr Mgst3 Upp2 Eefsec Ggps1 Ndufs2 Pgm2 Mgst1 Lbr Ndufs8 Pgm1 Inpp4a Hmmr Slco1b2 Cyb5a Bckdhb Psap Podxl2 Ces2h Kdsr Hs3st2 Mmab Gls2 Rpe Cyp2s1 Taldo1 Arnt D2hgdh Mbtps1 Srm Ahcyl1 B4galnt2 B4galnt1 G6pdx Nags Aspa Bcs1l Pfkp Bckdk Tmlhe Uroc1 Apoc2 Rab14 Mthfd1 Iars1 Folr2 Idh3b Stard3nl Cpt1a Apoc3 Xylt2 Ppm1k Cdo1 Rmnd5b Ckmt1 Ins2 Nhlrc1 Trib3 Ptgds Dmgdh Uqcrfs1 Slc10a2 Cerk Vdac1 Por Ppa1 Ppa2 Apoa1 Apoa2 Apoa4 Slc35d2 Pycr3 Pycr2 Hsd17b4 Dhrs7b Chac1 Ugt1a2 Cd320 Rab5if Neu3 Trap1 B4galt6 Ppp1r3c Neu1 Acsm4 Asl Acsm5 Pck1 Lmbrd1 Sdhaf1 Aimp1 Acer3 Plcz1 Rtel1 Stard5 Stard3 Ppat Retsat Arsj Arsi Apoe Glul Paics B3gnt2 Ugt2a1 Ugt2a2 Cyp39a1 Decr2 Ndufa12 Esrra Ugt2b1 Auh Nnt Acot12 Akap5 Nudt12 Cbr1 Maoa Plekha6 Timm21 Gaa Nme4 Nudt11 Nme1 Dera Enoph1 Gdpd5 Nme6 Cyp4f40 Gdpd1 Gnai2 Ctsa Fads2 Gsta5 B3galt2 Fads1 Adipor2 Kcns3 Nmnat2 Xdh Nubp1 Sepsecs Nqo1 Ppp1cc Ahcy Fabp3 Gch1 Fabp5 Fabp6 Tecr Hscb Uqcrc2 Arnt2 Inpp1 Adra2a Phyh Amacr Gda Amdhd1 Car14 Sdhc Sdhb Ndufaf2 Ndufaf1 Comt Shpk St6galnac5 Ggt1 Car7 Car6 Tyms Slc52a2 Nosip Sult4a1 Ampd3 Cyp11b1 Ampd2 Cyp11b2 Mpst Dpep1 Cox20 Coq4 Coq6 Acaa2 Fut9 Pik3cg Glyat Abhd10 Slc9a1 Prkag2 Pi4k2b Trmt112 Idh1 Idh2 Cryl1 Acbd6 Hspa9 Ca1 Ca3 Cox16 Ca2 Uqcc6 mt-Cytb Oplah mt-Nd4 mt-Nd5 mt-Nd6 Tat Mtr Nat8l A4galt Pfkfb4 Txnrd1 Pfkfb3 Glrx5 Pfkfb2 Pfkfb1 Mtarc1 Aox1 Hibch Ethe1 Pdss2 Lalba Adal Dct Fbp2 Pon3 Crym Pon1 Pon2 Mat2a Ndufa3 Ndufa7 Slc22a13 Abcd3 Cbs Galm Ptpn13 Ltc4s Hmgcl Rrm1 Ndufb2 Chdh Ndufb6 Ndufb8 Sgpp2 Vdr Hadha Gpcpd1 Ptpmt1 Ptdss2 Slc44a2 Pitpnb Cpne1 Pnpla3 Cpne3 Lpcat4 Pla1a Phospho1 Pgs1 Abhd3 Cpne6 Plaat3 Pla2g3 Mgll Csnk2b Gpat4 Etnk1 Chpt1 Gpat2 Lpin1 Stard10 Dgat2 Mboat7 Chkb Crls1 Prss2 Med23 Med24 Plin2 Morc2a Scd1 Ccnc Med16 Med17 Elovl5 Ncoa6 Cidec Fabp4 Med31 Ppargc1b Cdk8 Pdzd11 Psmd12 Psmd11 Psma6 Psmd8 Psmb1 Psmc2 Psma7 Slc5a6 Btd Pcx Acacb Akt1 Prkar2a Prkar1a Prkacb Nup205 Nup107 Sec13 Nup85 Nup88 Nup133 Nmt1 Hexb Cspg5 Hyal3 Ppp2r5d Pik3r1 Cyp2d22 Cyp2c65 Rps11 Pik3r4 Sdc3 Gpc3 Gpc2 Gpc4 Rps25 Rps26 St3gal4 Rps27 St3gal1 Rps21 Gna14 Gng3 Gnb2 Gnb1 Sphk1 Gnb4 St3gal6 Pank4 Ppcs Fasn Enpp2 Acsl3 Gck Rap1a Apob PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds Acsm5 Gstt1 Gstk1 Comt Mat2a Ggt1 Ugt2a1 Bpnt1 Ugt2a2 Glyatl3 Sult4a1 Ugt2b1 As3mt Sult1e1 Glyat Abhd10 Trmt112 Mgst3 Gsta5 Slc35d2 Mgst1 Chac1 Oplah Ugt1a2 Mtr Ahcy Podxl2 Acsm4 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis Tph1 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes P2rx7 Pycard Aim2 Sugt1 Casp1 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model Slc25a27 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects Ube2c Fzr1 Anapc11 Anapc10 Anapc1 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation Aimp1 Gars1 Iars1 Yars1 Vars1 Farsa Tars1 Ppa1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 Rap1a Crk Hgf Dock7 Gab1 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes Areg ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA Btla Ptpn11 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation Rpl4 Rps25 Rpl39 Rps26 Rpl22 Rpl18 Rpl7 Rps27 Rps21 Eef1g Rps11 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation Fgf7 Fgf22 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border Zic1 Myb Ctnnb1 Tcf7l1 Pou5f1 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) Akt3 Akt2 Tsc2 Akt1 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism Rpl4 Psmb1 Psmc2 Pipox Carns1 Rpl39 Psma7 Aimp1 Hibch Rpl7 Ethe1 Gls Dct Afmid Crym Glul Nmral1 Rpl22 Cbs Secisbp2 Ido2 Auh Tph1 Gadl1 Chdh Oaz2 Aldh7a1 Rps25 Ogdh Rps26 Inmt Enoph1 Rps27 Eefsec Rps21 Sepsecs Nqo1 Bckdhb Ahcy Gls2 Agmat Slc25a21 Arg2 Srm Amdhd1 Nags Aspa Bckdk Tmlhe Slc25a10 Uroc1 Rpl18 Iars1 Gnmt Gatm Mpst Ppm1k Cdo1 Ckmt1 Ckm Slc44a2 Glyat Dmgdh Sephs2 Pycr3 Hsd17b10 Pycr2 Tat Mtr Nat8l Psmd12 Serinc4 Psmd11 Serinc2 Psma6 Txnrd1 Crat Rps11 Serinc3 Asl Psmd8 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production Kif12 Akap1 Racgap1 Kif1c Kif21b Kdm1a Zfpm1 Zfpm2 Sh2b3 Kifc5b Gata1 Kif27 Ifna16 Dock1 Prkar2a Prkar1a Prkacb Itpk1 Cdk5 Dock7 H3c7 Myb Kif18a Kif2c Rbsn Hmg20b Maff Klc2 Hdac1 Capza1 Mfn1 Mfn2 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion Chia Clps Lipf Pir Amy2a5 Guca2a RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP Eif2b4 Eif2s3x Eif2s2 Eif2b1 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation Rab7 Nos2 Atp6v1h Coro1a Vps33b INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling Sod2 Hnrnpa2b1 Taldo1 Jak1 Tyk2 Hspa9 Ca1 Il12rb1 Il12rb2 Cfl1 Il12b Pdcd4 Capza1 Il12a Snrpa1 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity Bach1 Rbx1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids Slc7a7 Slc7a8 Slc38a3 Slc7a11 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes H2bu2 Men1 Yeats2 Ajuba Ccnc Hcfc1 Med16 Med17 Kansl2 Elovl5 Setd1b Ncoa6 Cidec H2bc9 H2bc7 H2bc8 Fabp4 Bod1 Tada2a Med31 Ppargc1b Phlda1 Cdk8 Cdk5 Psip1 H3c7 Mgll H2ax Med23 Lpin1 Med24 Plin2 Dgat2 Akap8l Phf20 Cxxc1 Scd1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors Lmbrd1 Aox1 Slc5a6 Btd Pcx Acacb Aldh1l1 Pdxk Slc22a13 Slc52a2 Mthfd1 Folr2 Slc25a51 Pank4 Ppcs Fasn Enpp2 Nudt12 Slc23a1 Slc46a1 Slc23a2 Slc19a1 Tcn2 Prss2 Pdzd11 Nmnat2 Cd320 Cyb5a Mtr Mmab ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated Ppp2r5d Mapk1 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response Adam17 Myh9 Mapk14 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 Fanci Ing2 Exo1 Meaf6 Fancc Bcl2l14 Rfc5 Gls Rfc3 Rfc4 Rfc2 Prelid1 Dyrk2 Mlst8 Wrn Prelid3a Mapk14 Zfp385a Npm1 Rpa2 Casp2 Rbbp8 Pml Mapkap1 Ttc5 Akt1 Rpa3 Hipk1 Pip4k2c E2f7 E2f8 Higd1c Ell Polr2g Gpi Taf11 Taf13 Taf12 Gtf2f1 Ssrp1 Taf7 Taf5 Taf2 Ppp2r5c Prkag2 Tnrc6a Csnk2b Cox6a1 Cox6a2 Txnrd1 Akt3 Akt2 Cpap Casp1 Tsc2 Ccne1 Phf20 Hdac1 Gls2 Jun G6pdx Tfdp2 Tfdp1 Polr2k Gtf2h2 Gtf2h3 Gtf2h5 Ercc3 Rbbp7 Cdk5 Trp53rkb Rabggta Pou4f1 Tnfrsf10b Pcna Fas Lamtor2 Gatad2a Pcbp4 Usp7 Perp Rffl Rad9a Bard1 Cradd Prkag3 Pidd1 Cnot7 Cnot6 Cnot9 Cdk12 Jmy Mdm2 Pin1 Banp Btg2 Ccna1 Ing5 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism Ckmt1 Ckm Gatm TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes Meaf6 Vps72 Suv39h2 Padi4 Kdm4d Brms1 Kdm4b Pbrm1 Prmt7 Trrap Arid5b Supt3 Kdm1b Kmt5b Kdm5c Kdm5b Msl1 Padi6 Ruvbl2 Ruvbl1 Kdm2a Setd3 Usp22 Setd7 Brd8 Elp1 Tada1 H2ax Kdm3b Elp6 Sap30l Kdm3a Taf12 Hmg20b Phf20 Hdac1 H2bu2 Sap30 Yeats2 Aebp2 Kdm1a Hcfc1 Kansl2 Setd1b Sap130 H2bc9 H2bc7 H2bc8 Tada2a Rbbp7 Gatad2a Ezh2 H3c7 Ing5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex Ube2c Anapc11 Anapc10 Anapc1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules Slc35d2 Pdzd11 Slc35b3 Slc35a1 Slc5a6 Slc27a1 Arl2bp Slc29a3 Slc28a2 Slc27a6 Slc29a4 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle Rnd3 Kctd13 Ktn1 Ankrd26 Tmod3 Txnl1 Pkp4 Sema4f Lemd3 Tnfaip1 Ckap4 Pik3r1 Ptpn13 Dsp Vangl2 Picalm SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants Kit BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers Slc9a1 Slc9a4 Slc9a2 Slc9a3 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Ctnnb1 Mapk14 Nup107 Sec13 Ppp1cc Dsp Nup85 Vangl2 Picalm Rnd3 Kctd13 Ktn1 Nup133 Ankrd26 Tmod3 Txnl1 Pkp4 Sema4f Lemd3 Tnfaip1 Ckap4 Srgap1 Srgap2 Ppp2r5e Cdc42bpa Daam1 Ppp2r5d Cdc42ep1 Ppp2r5c Tpm3 Ppp2r5b Nckap1l Ppp2r5a Stk38 Cdc37 Erbin Tex2 Plxna1 Wipf3 Bcr Actr2 Actr3 Ar Prkcb Btk Stom Flna Jag1 Arap2 Senp1 Syde2 Atp6ap1 Mcam Myh10 Ska1 Cpne8 Ahctf1 Myo6 Abl2 Nf2 Dynll2 Frs2 Nipsnap2 Ptk2 Pik3r1 Rasgrf2 Plxnd1 Cyba Cybb Nox3 Arpc4 Rab9 Spata13 Nudc Aldh3a2 Mtr Rhof Rhod Arhgef15 Arhgef17 Arhgef11 Arhgdig Nuf2 Rac2 Noxa1 Emd Dync1h1 Git1 Iqgap2 Iqgap3 Arhgap15 Diaph2 Diaph3 Stam2 Arhgap17 Efhd2 Dynll1 Sptan1 Usp9x Fam13b Dync1i2 Fnbp1 Actn1 Pik3r4 C1qbp Evl Arhgap22 Abcd3 Rhobtb3 Scai Baiap2l1 Ptpn13 Cenpa Golga3 Vma22 Pkn3 Ophn1 Was Nsl1 Slitrk5 Slitrk3 Nhs Emc3 Csk Gopc B9d2 Myo9a Rps27 Prex1 Wasf3 Actc1 Wasf2 Dock7 Taok1 Plekhg1 Farp1 Sh3bp1 Prag1 Abi2 Cenpm Lbr Pkn2 Cenpi Pkn1 H2ax Map3k11 Cenpf Kif18a Arhgap42 Kif2c Ccne1 Klc2 Mfn1 Mfn2 H2bu2 Men1 Racgap1 Kdm1a Cct7 Dock1 Rab7 Rhoa H2bc9 Cfl1 H2bc7 H2bc8 Ddx39b Myh9 H3c7 S100a9 Mapk1 Pin1 DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells Hdac5 Maf Men1 Rbbp7 Klf13 Jun Mamld1 Gatad2a Cbx4 Il13 Il12rb2 Satb1 Bmi1 Tnf Phc3 Hdac1 Batf Yy1 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration Idh1 Aco1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine Nagk Amdhd2 Gfpt1 Renbp TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling Tbk1 Tnfrsf1a Sharpin Birc3 Mib2 Birc2 Traf2 Tnf Ripk1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex H2bu2 Men1 Ctnnb1 Trrap Axin2 Ruvbl1 H3c7 Tcf7l1 H2ax H2bc9 H2bc7 H2bc8 Hdac1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins Aqp6 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome Psmb1 Psmc2 Psma7 Btrc Psmd12 Prkacb Psmd11 Rbx1 Psma6 Psmd8 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Tbk1 Tlr4 Ly96 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi St3gal4 Mgat4a Mgat4b B4galt6 St6gal1 Mgat5 Mgat3 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation Jun Irak1 Mapk14 Map3k8 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ripk2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway Fanci Ing2 Exo1 Meaf6 Fancc Bcl2l14 Rfc5 Gls Rfc3 Rfc4 Rfc2 Prelid1 Dyrk2 Mlst8 Wrn Prelid3a Zfp385a Med8 Npm1 Rpa2 Casp2 Rbbp8 Pml Mapkap1 Ttc5 Rpa3 Hipk1 Pip4k2c E2f7 E2f8 Higd1c Pbrm1 Kdm5b Gpi Kit Ar Prkcb Nr3c1 Vdr Rara Csnk2b Cox6a1 Cox6a2 Egfr Cpap Usp9x G6pc1 Lbr H2ax Med23 Med24 Cbx4 Bmi1 Phf20 Phc3 Hdac1 Yy1 H2bu2 Hdac5 Gls2 Men1 Maf Arnt Ccnc Zfp141 Med16 Med17 G6pdx Zfp454 Znf382 Mef2c Polr2k Zfp157 Nkx2-5 Zfp398 Setd1b Zfp712 Twist2 Gtf2h2 Zfp707 Zfp248 Gtf2h3 Zfp872 Gtf2h5 Tead4 Esrrb H2bc9 Zfp740 H2bc7 Zfp184 H2bc8 Zkscan5 Zfp746 Foxp3 Krba1 Med31 Ins2 Camk4 Ercc3 Ctla4 Rbbp7 Znf2 Ppargc1b Zfp28 Znf583 Rybp Cdk8 Pcgf2 Cdk5 Npy Zfp324 Zfp11 Satb2 Ucma Gatad2a Tead3 Ezh2 Tead2 H3c7 Zfp605 Atad2 Lifr Zfp791 Agrp Cdkn2b Msx2 Zfp30 Serpinb13 Pvalb Zfp426 Zfp664 Csf2 Il2 Psmd12 Zfp51 Znf551 Psmd11 Psma6 Zfhx3 Psmd8 Smad4 Psmb1 Cdk6 Pck1 Psmc2 Auts2 Tcf3 Ctnnb1 Ldb1 Psma7 Zfp473 Kcnip3 Mybl2 Znf771 Znf641 Rbm14 Mobp Nrbp1 Dgcr8 Camk2g Apoe Camk2d Mapk14 Camk2b Zfp697 Camk2a Mga Tbx5 Pitx2 Zfp560 Zfp445 Akt1 Esrra Zfp202 E2f6 Rbx1 Itch Ell Polr2g Taf11 Taf13 Taf12 Gtf2f1 Arnt2 Ssrp1 Taf7 Taf5 Taf2 Ppp2r5c Jag1 Hnf4a Prkag2 Tnrc6a Brd2 Kctd1 Kctd15 Ube2c Fzr1 Anapc11 Anapc10 Cdkn2a Anapc1 Txnrd1 Akt3 Akt2 Ptpn11 Casp1 Irak1 Myb Tcf7l1 Tsc2 Ccne1 Zfpm1 Gata1 Jun Mamld1 Notch3 Tfdp2 Tfdp1 Sod2 Trp53rkb Rabggta Tnfrsf10b Pou4f1 Fas Pcna Lamtor2 Pcbp4 Usp7 Perp Rffl Rad9a Bdnf Bard1 Gck Cradd Prkag3 Pidd1 Cnot7 Cnot6 Cnot9 Cdk12 Jmy Mapk1 Mdm2 Pin1 Banp Btg2 Ing5 Ccna1 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis Hscb Lyrm2 Ndufaf2 Ndufaf1 Tmem186 Hspa9 Ndufs2 Ndufa3 Ndufa7 Ndufs8 mt-Nd4 Ndufa12 mt-Nd5 mt-Nd6 Ndufb2 Ecsit Ndufb6 Ndufb8 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Crtc1 Cry1 Tfeb TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion Hsd17b10 Trmt10c Prorp Elac2 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway Fga Gpc3 F10 Gpc2 F12 F11 Gpc4 Fgg F2 F9 Serpine2 Ano6 Smpd1 Prtn3 Sdc3 Klkb1 Fgb MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling Slc25a27 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle Chmp6 Pdcd6ip Ssrp1 Nup133 Taf7 Nmt1 Taf5 Taf2 Polr2k Gtf2h2 Gtf2h3 Gtf2h5 Ercc3 Ell Polr2g Ubap1 Nup205 Nup107 Tsg101 Sec13 Taf11 Mvb12a Taf13 Taf12 Rcc1 Gtf2f1 Nup85 Chmp3 Nup88 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins Pias3 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage Ada Ampd3 Adal Ampd2 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase Prkar2a Prkar1a Prkacb DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins Adamtsl5 Thsd4 Adamts1 Muc1 Adamts20 Adamts10 Sema5a Thsd7a Notch3 Cfp Thbs2 Muc4 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication Rpl4 Nup133 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Polr2k Polr2g Nup205 Nup107 Rpl22 Rpl18 Sec13 Gtf2f1 Nup85 Nup88 Rps11 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures Exo1 Eme1 Bard1 Mus81 Rbbp8 Palb2 Rtel1 Wrn DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Slc17a8 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action Ifit3b ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) Chmp6 Ubap1 Tsg101 Vps25 Mvb12a Stam2 Chmp3 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport Ano6 Camk2g Camk2d Camk2b Camk2a Atp2b2 Atp2b1 Asic4 Clca1 Atp8a1 Atp6v0a4 Clcn2 Clcn3 Clcn1 Atp4a Atp4b Atp11b Atp13a1 Atp8b3 Ttyh2 Sgk3 Sgk2 Atp12a Atp1a1 Scnn1b Atp9b Scnn1g Tcirg1 Tpcn1 Tpcn2 Clcn6 Tsc22d3 Clcn7 Clcn4 Atp1b1 Clcn5 Atp1b3 Atp6v1a Atp6v0d2 Atp6v1h Bsnd Atp6v1f Slc9b2 Stom Atp6ap1 Trpc6 Trpv4 Trpv6 Trpm8 Trpm4 Pdzd11 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Rhoa Tgfbr1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection Adam17 Gng3 Gnb2 Gnb1 Gnb4 Myh9 Ahcyl1 Gnai2 Mapk14 Plcg2 Ggt1 Prkar2a Prkar1a Gnaz Cysltr1 Prkacb Dpep1 Cd3g DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function Opn1sw SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 Cbl Mapk1 Gab1 Frs2 Ptpn11 Pik3r1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Nkiras2 Peli1 Myd88 Usp14 Jun Irak1 Traf2 Mapk14 Tlr4 Map3k8 Ly96 Tlr7 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ecsit Ripk2 Nkiras1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation Fgf22 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism Mgll Mogat1 Gpat2 Lpin1 Ppp1cc Dgat2 Abhd5 Fabp3 Prkacb Fabp4 Fabp5 Fabp6 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism Glul ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism Hmgcl Aacs RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs Men1 Ctnnb1 Iqgap2 Iqgap3 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste Calhm1 Scnn1b Scnn1g N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation St3gal4 Mgat4a Mgat4b B4galt6 St6gal1 Mgat5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly Nup205 Nup133 Nup107 Nek9 Sec13 Nek6 Nup85 Ccnb2 Nup88 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A Akt3 Akt2 Akt1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry Gpc3 Gpc2 Gpc4 Sdc3 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling Akt3 Akt2 Akt1 Mapk1 Areg Egfr Ptk2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism Slc35d2 Gpc3 Gpc2 Glce Gpc4 Sdc3 Hs6st2 Hs3st2 Ndst3 Hpse GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis Bloc1s1 Bloc1s3 Tbc1d8b Dnajc6 Bloc1s4 Ap1s3 Tpd52l1 Rab5c Ap3b1 Fth1 Sort1 Hip1r Arrb1 Picalm THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 Csf2ra Sftpa1 Sftpd RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Tubgcp5 Tubgcp4 Nedd1 Actr1a G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling Gng3 Gnb2 Akt3 Pik3cg Akt2 Gnb1 Rhoa Gnb4 Akt1 Btk Pik3r5 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling Adam17 Irs2 Prlr Mapk1 Irs1 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis Coq6 Coq8a Pdss2 Coq4 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling Psmb1 Fzd6 Psmc2 Gng3 Rac2 Pde6a Pde6b Gnb2 Ctnnb1 Prickle1 Gnb1 Psma7 Gnb4 Ap2a2 Ap2a1 Camk2a Daam1 Rhoa Prkcb Tnrc6a Tcf7l1 Wnt5a Psmd12 Wnt5b Ppp3cb Psmd11 Gnat2 Vangl2 Psma6 Fzd4 Psmd8 Fzd7 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation Myo6 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) Il12rb2 Tnf MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease Bckdhb Ppm1k NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants Alk P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response Psmb1 Psmc2 Cop1 Psma7 Pcbp4 Zfp385a Ccne1 Psmd12 Phf20 Mdm2 Psmd11 Psma6 Ccna1 Psmd8 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport Ift122 Dynlt2b Ift43 Ift81 Ift52 Ift56 Dynll1 Dynll2 Ift140 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha Arnt2 Arnt Ccnc Med16 Med17 Mtf1 Med8 Cyp7a1 Ncoa6 Esrra Me1 Cpt1a Thrap3 Med31 Trib3 Ppargc1b Fhl2 Cdk8 Apoa1 Apoa2 Fads1 Med23 Slc27a1 Med24 Plin2 Txnrd1 Med28 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants Alk ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets Mef2c Ppp2r5d Mapk1 Mapk14 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions Lgi2 Adam11 Adam23 Cacng3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism Btd Pcx ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation Psmb1 Psmc2 Psma7 Kctd7 Hectd1 Hectd3 Rnf220 Ube2b Mkrn1 Blmh Ube2a Fbxl20 Rnf213 Btbd1 Btrc Rnf138 Ube2v1 Fbxw8 Asb16 Ube2l3 Rnf126 Rbx1 Dcaf1 Herc2 Fbxo21 Itch Ubox5 Ube2r2 Rnf6 Uba6 Fbxo7 Trim21 Klhl25 Klhl20 Klhl2 Spsb2 Fbxl14 Spsb1 Fbxl16 Trim37 Fbxl19 Lonrf1 Asb7 Rnf25 Rchy1 Ube2j1 Fbxw4 Mib2 Uba7 Cdc34 Ube2c Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Psmd8 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors Drd4 Drd5 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin Maoa ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis Xrn2 Sphk1 Cct7 Ccne1 Kif13a Ap3m1 Fbxw4 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion Gng3 Gnb2 Adra2a Gnb1 Gnb4 Gnai2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death Sod2 H2bu2 Rbbp7 Cdk5 Jun Traf2 Ripk1 Ezh2 H3c7 C1qbp H2ax Golga2 Pola2 Gsdme H2bc9 H2bc7 H2bc8 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism Ptgr2 Mecr Phyh Amacr Acot3 Hacd1 Acot9 Pon3 Acly Slc25a17 Pon1 Elovl1 Pon2 Elovl6 Ggt1 Elovl5 Decr2 Ltc4s Cpt1a Acot12 Fasn Dpep1 Cbr1 Acsl3 Hadha Acaa2 Ptgds Hao2 Prkag2 Cyp4f40 Acbd6 Mcee Fads2 Hacl1 Ppt1 Fads1 Hsd17b4 Cyp2c65 Slc27a1 Morc2a Crat Scd1 Tecr TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors Camk2a Myo6 Mdm2 Akap5 Cacng3 Prkcb Camk2g Camk2d Camk2b Ap2a1 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 Fgf7 Polr2k Polr2g Fgf22 Cbl Hnrnpa1 Mapk1 Gab1 Gtf2f1 Frs2 Ptpn11 Pik3r1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance Ercc3 Taf7 Taf5 Taf2 Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 Psmb1 Psmc2 Ctnnb1 Psma7 Eps15 Psmd12 Mdm2 Psmd11 Banp Psma6 Psmd8 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis Myh9 Wasf3 Ahcyl1 Wasf2 Nf2 Ptk2 Pik3r1 Abi2 Plcg2 Dock1 Nckap1l Arpc4 Wipf3 Crk Cfl1 Mapk1 Actr2 Myo10 Actr3 Myo5a Was Cd3g Btk FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope Pkp1 Lipk Ppl Klk14 Lipn Pkp4 Dsp Lce3b Lce1m Perp Klk5 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response C1qbp Gsdmd Casp3 Gsdme Mapk1 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase Pde10a Nos2 Pde11a Kcnmb1 Pde1a Kcnmb4 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere H2bu2 Polr2k Polr2g H2ax H2bc9 H2bc7 Terf2 H2bc8 Atrx Terf2ip MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling Hgf Gab1 Pik3r1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint Nuf2 Nup133 Dync1h1 Dynll1 Dync1i2 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cenpa Nsl1 B9d2 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Ube2c Nudc Kif2c Ppp1cc Anapc11 Anapc10 Anapc1 Nup85 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals Dcc Ptpn11 Unc5c PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy Epas1 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism Tat SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction Pals1 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants Flt3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA Rpl4 Ascc2 Rps25 Rpl39 Rps26 Rpl22 Rpl18 Rpl7 Rps27 Rps21 Rps11 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity Psmb1 Psmc2 Akt3 Akt2 Psma7 Csnk2b Rnf146 Mkrn1 Frk Akt1 Psmd12 Psmd11 Psma6 Psmd8 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs Camkk2 Git1 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection Gng3 Noxa1 Gnb2 Gnb1 Gsdmd Gnb4 Ahcyl1 Jun Mapk14 Ggt1 Plcg2 Dock1 C3ar1 Nckap1l P2rx4 Prkar2a Wipf3 Crk Prkar1a Gnaz Actr2 Ctsg Cysltr1 Prkacb Actr3 Was Dpep1 Cd3g Btk Adam17 P2rx7 Pycard Sugt1 Casp1 Myh9 Wasf3 Wasf2 Gnai2 Ptk2 Abi2 Cyba Arpc4 Wnt5a Mapk1 Myo10 Myo5a Fzd7 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism St6galnac5 Slc35a1 St3gal4 St6galnac3 Gne St3gal6 Neu3 St3gal1 St6gal1 Neu1 Ctsa STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling Hdac1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) H2bu2 Kdm5b H3c7 Srpk1 Pabpc1 H2ax Cnot7 Cnot6 Pabpn1 Cnot9 Zfp36l2 Tead4 H2bc9 Eif4b H2bc7 Eif4e H2bc8 Dicer1 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission Gng3 Gnb2 Git1 Gnb1 Gnb4 Cacng3 Camk2g Camk2d Camk2b Ap2a1 Camk2a Camkk2 Prkar2a Prkar1a Akap5 Prkacb Kcnj5 Prkcb Gabra4 Glrb Gabbr2 Camk4 Lin7c Grin3b Chrnd Lrrc7 Gabrr1 Glra3 Prkag2 Gabrr3 Gabrr2 Nrgn Myo6 Kcnj3 Kcnj10 Grik5 Gnai2 Gabrb3 Grik4 Kcnj15 Rasgrf2 Chrna9 Prkag3 Chrnb2 Mapk1 Mdm2 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development Ins2 Akt3 Akt2 Mamld1 Pdx1 Onecut3 Gck Nkx2-2 Mafa Neurod1 Foxa2 Ptf1a Akt1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2bu2 Rbbp7 H2ax Pola2 Gsdme H2bc9 H2bc7 H2bc8 Ezh2 H3c7 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium Tuba1a Kif24 Cdk5rap2 Sclt1 Cep250 Sdccag8 Dync1h1 Dynlt2b Cep78 Ift43 Pcm1 Ift81 Ift56 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Ift52 Ift140 Ift122 B9d2 Dynll2 Tctn3 Arl6 Pkd2 Mchr1 Bbs7 Rab11a Nedd1 Ahi1 Actr1a Exoc7 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Rpl4 Psmb1 Psmc2 Tcf25 Rpl39 Psma7 Rpl7 Rchy1 Rpl22 Rpl18 Psmd12 Rbx1 Psmd11 Psma6 Psmd8 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism Lmbrd1 Cd320 Tcn2 Mtr Prss2 Mmab SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members Men1 Tcf3 Myog Myod1 Strap Ccnc Itgav Tgfb2 Acvr1b Amh Cer1 Bmpr1a Bmpr1b Bmpr2 Ppp1r15a Usp9x Tfdp2 Usp15 Tfdp1 Psen2 Smad5 Cbl Rhoa Rara Cdk8 Mtmr4 Tnrc6a Arrb1 Cdkn2b Tgfbr1 Ppp1cc Mapk1 Hdac1 Smad4 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Npm1 Mybl2 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily H2bu2 Pck1 Rbbp7 Gatad2a H3c7 Pwwp2a Zmynd8 Tcf19 H2ax Ikzf1 Pwwp2b G6pc1 Adnp H2bc9 H2bc7 H2bc8 Hdac1 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp2c65 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression Kdm4b H2bu2 Kdm1a Jun H3c7 Polr2k Polr2g Tnrc6a Myb H2ax Nrip1 Stag2 H2bc9 Smc3 H2bc7 Fkbp4 H2bc8 Gtf2f1 Hdac1 Yy1 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA Hadha TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling Tek Angpt4 Ptpn11 Pik3r1 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors Pabpc1 Cnot7 Cnot6 Cnot9 Zfp36l2 Eif4b Eif4e Dicer1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Ccna1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) Rfc5 Rfc3 Rfc4 Rfc2 Rpa2 Gtf2h2 Gtf2h3 Rpa3 Gtf2h5 Pias3 Rbx1 Xpc Ddb1 Parp2 Rad23a Ercc3 Rad23b Rfc1 Pold4 Cops8 Cops7a Cops7b Pcna Ruvbl1 Yy1 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance Ap2a2 Apob Ap2a1 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events Chrna9 Chrnd Chrnb2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation Ins2 Irs2 Mapk1 Irs1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria Nmt1 Gzmb REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling Jak1 Ptpn11 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism Acer3 Sgpp2 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs Rpl4 Psmb1 Psmc2 Ldb1 Rpl39 Psma7 Rpl7 Pabpc1 Rpl22 Rpl18 Rbx1 Rps25 Rps26 Rps27 Hoxa2 Slit1 Msi1 Col4a5 Rps21 Lhx2 Etf1 Upf3a Gspt1 Psmd12 Psmd11 Psma6 Rps11 Psmd8 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes H2bu2 Ajuba Ccnc Med16 Med17 Elovl5 Ncoa6 Cidec H2bc9 H2bc7 H2bc8 Fabp4 Med31 Ppargc1b Phlda1 Cdk8 Cdk5 H3c7 Mgll H2ax Med23 Lpin1 Med24 Plin2 Dgat2 Scd1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants Kit ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Rps25 Rps26 Rps27 Rps21 Pabpc1 Eif3l Eif3e Eif2s3x Eif4ebp1 Eif2s2 Eif3b Eif3c Eif4b Eif4e Rps11 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing Nthl1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events Camk4 Ahcyl1 Pde1a Camk2g Camk2d Camk2b Camk2a Plcb4 Camkk2 Prkar2a Prkar1a Mapk1 Prkacb Gna14 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus Ip6k2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane Pik3r4 Inpp5f Inpp4a Pi4k2b Mtm1 Mtmr4 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin F2 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation Mmp20 Mmp7 Col4a5 Mmp9 Bmp1 Tll1 Col4a4 Col15a1 Serpinh1 Col6a3 Col17a1 Pxdn Col18a1 Itgb4 Loxl1 Col12a1 Ppib Loxl3 Plec DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle Ppfia2 Ppfia4 Lin7c Cplx1 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 Camk4 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) Edem2 Rnf103 Rnf139 Edem3 Syvn1 Trim13 Uggt1 Uggt2 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation Ctnnb1 Pou5f1 Smad4 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling Psmb1 Rac2 Psmc2 Akt3 Akt2 Psma7 Mlst8 Mkrn1 Pml Mapkap1 Akt1 Pip4k2c Ptpn11 Hgf Irak1 Gab1 Areg Fgf7 Fgf22 Tsc2 Cbx4 Bmi1 Hdac1 Phc3 Hdac5 Kdm1a Klb Jun Fgf15 Kit Ier3 Phlpp1 Il33 Pik3r5 Strn Flt3 Egr1 Ppp2r5e Akt1s1 Rnf146 Ppp2r5d Snai1 Ppp2r5c Frk Ppp2r5b Ppp2r5a Ins2 Rbbp7 Myd88 Trib3 Pik3cg Lamtor2 Gatad2a Irs1 Ezh2 Frs2 Usp7 Pik3r1 Bdnf Tnrc6a Csnk2b Irs2 Mapk1 Psmd12 Mdm2 Psmd11 Egfr Psma6 Psmd8 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis Chmp6 Peli1 Pdcd6ip Casp1 Gsdmd Casp3 Gzmb Birc3 Tnfrsf10b Birc2 Fas Traf2 Ripk1 Cdc37 Gsdme Ube2l3 Chmp3 Itch G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events Rasgrf2 Gng3 Gnb2 Gnb1 Rhoa Prex1 Gnb4 Arhgef15 Arhgef17 Arhgef11 Btk DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease Rpl4 Rpl39 Rpl7 Med8 Psen2 Plcg2 Rpl22 Fkbp4 Gns Gzmb Tcn2 Ada Nthl1 Ppib Cyp7b1 Med28 Syvn1 Klb Fgf15 Strn Pik3r5 Akt1s1 Phf5a Tyro3 Abcb6 Dctn1 Rpl18 Sv2a Dkk1 Bin2 Avpr1b Rdh12 EG433182 Cldn1 Jag2 Fgfr3 Bcl11a Mras Ctbp1 Sec31a Icos Agtrap Brd4 Xab2 Sf3b6 Ctnnbl1 S100a1 Snrpn Mapre3 Bag2 Cherp Kpna4 Hhat Sigmar1 Ly6e Chmp1a Isy1 Slc12a6 Sh3kbp1 Puf60 Unc93b1 Ppil4 Slc37a4 Ppil1 Bcl2a1d E2f2 Il1r1 Gcc2 Prf1 Cog1 Kdr Alg8 Grpel1 Alg3 Erlin2 Erlin1 Slc26a2 Hnrnpr Zmym2 Slc5a1 Elavl2 Foxm1 Kremen1 Sugp1 Ctr9 Hip1 Nudt21 Slc6a2 Nmral1 Slc6a5 Cd300a Srrm2 C1qa Slc20a2 Apbb1ip G6pc1 Zc3hav1 Mib1 Prpf6 Slc40a1 Ppig Ppih Dhdds Epcam Fgfr1op2 Prpf8 Wbp11 Rtn3 Syt2 Pqbp1 Cgas Oas2 Blnk Dnaja2 Eif4g3 Slc22a12 Slc22a18 Cd9 Gbp2 Hes5 Dusp10 Heph Pgm1 Slco1b2 Bckdhb Mmab Taldo1 Ahcyl1 Nags Bckdk Ppm1k Nhlrc1 Apoa1 Cd320 Ppp1r3c Neu1 Asl Lmbrd1 Auh Maoa Gaa Gnai2 Ctsa Ppp1cc Ahcy Comt Ggt1 Cyp11b1 Cyp11b2 Dpep1 Pik3cg Idh1 Oplah Mtr Txnrd1 Hibch Galm P2rx7 Pycard Sugt1 Casp1 Hgf Gab1 Areg Eef1g Fgf7 Fgf22 Tsc2 Hmg20b Kdm1a Rab7 Nos2 Atp6v1h Coro1a Snrpa1 Sod2 Hnrnpa2b1 Slc7a7 Myh9 Rad9a Bard1 Mdm2 Exo1 Rfc5 Rfc3 Rfc4 Rfc2 Mlst8 Wrn Npm1 Rpa2 Rbbp8 Pml Mapkap1 Rpa3 Brms1 Slc29a3 Kit Tpm3 Nckap1l Wipf3 Bcr Actr2 Actr3 Nr3c1 Btk Dynll2 Ptk2 Csnk2b Cyba Arpc4 Egfr Rac2 Noxa1 Dync1h1 Stam2 Dynll1 Dync1i2 C1qbp Btrc Ctsg Was Klkb1 Adam17 Csk Adamts1 Wasf3 Wasf2 Taok1 Mmp9 Abi2 Map3k11 H2ax Med23 Sap30l Med24 Hdac1 H2bu2 Hdac5 Sap30 Gfpt1 Ccnc Med16 Med17 Mib2 Polr2k Gtf2h2 Gtf2h3 Gtf2h5 H2bc9 H2bc7 H2bc8 Med31 Camk4 Ercc3 Rbbp7 Cdk8 Cdk5 Psip1 Gatad2a Ezh2 H3c7 S100a9 Psmd12 Psmd11 Psma6 Psmd8 Smad4 Psmb1 Cdk6 Psmc2 Ctnnb1 Psma7 Btd Pcx Nrbp1 Camk2g Camk2d Mapk14 Camk2b Pabpc1 Camk2a Akt1 Prkar2a Prkar1a Prkacb Rbx1 Itch Fgb Fga F10 F12 F11 Slc35a1 Fgg F2 F9 Nf1 Muc1 Adamts20 Adamts10 Spred1 Sema5a Thsd7a Spred3 Cfp Spred2 Thbs2 Muc4 Ell Adamtsl5 Thsd4 Polr2g Ubap1 Nup205 Palb2 Nup107 Slc17a8 Tsg101 Ifit3b Sec13 Vps25 Taf11 Mvb12a Taf13 Taf12 Rcc1 Gtf2f1 Nup85 Chmp3 Nup88 Chmp6 Pdcd6ip Ssrp1 Nup133 Xrcc4 Taf7 Nmt1 Taf5 Atp1a1 Taf2 Hexb Cspg5 Uba7 Rigi Ap2a2 Ap2a1 Clcn6 Ppp2r5e Ppp2r5d Atp1b1 Ppp2r5c Ppp2r5b Atp1b3 Ppp2r5a Cdc37 Erbin Phb1 Gnaz Cysltr1 Cd3g Opn1sw Jag1 Myd88 Alk Ap1s3 Irs1 Frs2 Rab5c Pik3r1 Ap3b1 Arrb1 Csf2ra Sftpa1 Ube2c Irs2 Fzr1 Anapc11 Anapc10 Wnt5a Cdkn2a Anapc1 Mgat5 Fzd4 Dad1 Fzd7 Rps11 Fzd6 Tufm Edem2 Tbk1 Akt3 Akt2 Jak1 St6galnac3 Iscu Tyk2 Vps33a Vps33b Stt3b Ano6 St6gal1 Ifna16 Tlr7 Zdhhc3 Pik3r4 Ganab Rpn2 Sdc3 Zdhhc9 Rpn1 Rnf213 Vps11 Ube2v1 Nod1 Pals1 Vps16 Golga7 Ripk2 Sftpd Ptpn11 Gpc3 Gpc2 Magt1 Gpc4 Uba6 Rps25 Rps26 St3gal4 Rps27 Mgat4a Mgat4b St3gal1 Irak1 Il17f Rps21 Il17a Srpk1 Gemin2 Tmem258 Tab2 Ddx20 H2-Q10 Golga2 Pola2 Gsdme Hnrnpa1 Eps15 Ccne1 Myo10 Myo5a Gng3 Gnb2 Gnb1 Gsdmd Gnb4 Jun Mamld1 Atrx Notch3 E2f3 Tfdp2 Flt3 Tfdp1 Dock1 Cbl C3ar1 P2rx4 Gne Sfpq Pabpn1 Crk Eif4e Fasn Dhx38 U2af1l4 Traf2 Ripk1 Tlr4 Ly96 Bdnf Gck Tgfbr1 Rap1a Map2k2 Map2k1 Mapk1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery Gemin2 Ddx20 Rps25 Rps26 Rps27 Rps21 Rps11 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids Hsd17b4 Decr2 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease Kdr Bin2 Strn Pik3r1 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 Fgf22 Gab1 Frs2 Ptpn11 Pik3r1 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor Ins2 Trib3 Atp6ap1 Akt2 Klb Fgf15 Gab1 Tcirg1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Atp6v1a Atp6v0d2 Atp6v1h Irs2 Atp6v1f Mapk1 Atp6v0a4 Ptpn11 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis Abo CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly Serpinb1a LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis Ugt1a2 Fabp6 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs Pabpn1 Nudt21 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation Prkcb SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) Psmb1 Psmc2 Csnk2b Psma7 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins Fga Fgg Apbb1ip Rap1a Crk Fgb Ptk2 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport Gng3 Gnb2 Myo5b Gnb1 Gnb4 Prkar2a Prkar1a Prkacb Aqp6 Rab11a CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters Slc12a6 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus Jag1 Psen2 Adam17 Arrb1 Mib1 Mib2 Jag2 Itch MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation Mrps16 Tufm Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mrpl47 Mrpl49 Mrps23 Mrps28 Mrpl52 Mrpl33 Tsfm Mrpl11 Mrpl34 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA Psmb1 Psmc2 Pabpc1 Psma7 Psmd12 Psmd11 Psma6 Psmd8 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 Rpa2 Rfc1 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna Mad2l2 Rev1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors Scara5 Fth1 Hsp90b1 Apoa1 Msr1 Apoe Apob Scgb3a2 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System Areg AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol Akt1s1 Mkrn1 Akt3 Akt2 Tsc2 Akt1 Mdm2 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib Cdc37 Erbin APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection Psip1 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly Hscb Uqcrc2 Uqcc6 mt-Cytb Uqcrfs1 Lyrm4 Hspa9 Bcs1l SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer Cdc37 Erbin Gab1 Egfr Pik3r1 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria Gsdmd Gsdme INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade Gpc3 F10 Gpc2 Gpc4 Sdc3 F2 F9 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis Chmp6 Casp1 Gsdmd Casp3 Gzmb Gsdme Chmp3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy Atp6v1a Atp6v1h Asah1 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins H2bu2 Pcna Ctr9 Ube2b Rnf152 Rnf40 Rnf144a Ube2a H2-Q10 Pex12 Prkdc Tmem129 H2bc9 H2bc7 Ube2l3 H2bc8 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion Inmt EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Trmt112 Rps21 Etf1 Gspt1 Rpl22 Rpl18 Rps11 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling Ggt1 Chac1 Oplah ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling Jak1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation Epcam FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism Csf2ra Sftpa1 Sftpd MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression Mtf1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility Rhoa Memo1 Egfr SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer Cbl Cdc37 Gab1 Egfr Pik3r1 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) Sv2a DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA Hnrnpr Sugp1 Nudt21 Srrm2 Prpf6 Ppig Ppih Prpf8 Wbp11 Pqbp1 Polr2g Nup205 Nup107 Sec13 Hnrnpa1 Gtf2f1 Nup85 Nup88 Xrn2 Nup133 Polr2k Phf5a Pabpn1 Prpf3 Snrnp25 Snrnp27 Eif4e Cactin Pnn Ccdc12 Prpf40a Ddx39b Snrpa1 Rbmx2 Dhx38 Thoc1 Hnrnpa2b1 Nsrp1 Thoc3 Snrnp35 Srsf10 U2af1l4 Thoc6 Prpf4b Prpf18 Cwf19l2 Xab2 Snrpc Sf3b6 Ctnnbl1 Prpf38a Ppil2 Snrpn Mettl3 Steep1 Dhx35 Cherp Lsm2 Lsm8 Ppwd1 Isy1 Puf60 Ppil4 Ppil1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity Adipor2 Prkag2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 Muc1 Muc4 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking Rab38 Trappc4 Trappc11 Akt3 Tbc1d10b Akt2 Rab1b Ankrd27 Gabarap Tbc1d24 Rin2 Rab14 Rab7 Akt1 Rab5c Gdi1 Dennd6a Dennd6b Dennd2b Trappc10 Dennd4b Rab9 Gga3 Tsc2 Dennd2d Rab27a Tbc1d13 Rab11b Trappc6b Rab13 Rab11a Trappc6a Gabarapl2 Trappc8 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation Rpa2 Rpa3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly Col17a1 Itgb4 Plec POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway Tubal3 Tuba1a Tubb2a PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis Polr2k Polr2g Tdrkh Mybl1 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity Zic1 Akt3 Ctnnb1 Aimp1 Iars1 Kit Mapk1 Tfeb Alx3 Mitf Hdac1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin Psmb1 Psmc2 Psma7 Ube2c Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Psmd8 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins Pkp1 Ctnnb1 Casp3 Satb1 Birc2 Dsp Clspn Sptan1 Ptk2 Plec DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Gck HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Chrnd Chrnb2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Akt1 Exosc9 Dcp2 Exosc8 Mapk14 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC Pik3r4 Sec31a H2-Q10 Sec13 Erap1 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation Rffl Akt3 Ppp2r5c Akt2 Mapkap1 Akt1 Phf20 Mdm2 Mlst8 Usp7 Ccna1 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate Tkt Taldo1 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer Akt1s1 Akt3 Akt2 Mapkap1 Tsc2 Akt1 Mdm2 Mlst8 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes Ggt1 Oplah Cyp11b1 Ahcy Cyp11b2 Cyp7b1 Maoa BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) H2bu2 H2ax Kdm5b H2bc9 H2bc7 H2bc8 H3c7 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation Tnrc6a WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 Wnt5a Prkcb Ap2a2 Fzd4 Ap2a1 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation Polr3d Polr2k Polr3f Polr3k Polr3a BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis H2bu2 Terf2 Terf2ip H3c7 Rpa2 Sun1 Rbbp8 Stag3 H2ax Mlh3 Rec8 Rpa3 Smc1b Stag2 H2bc9 Smc3 H2bc7 H2bc8 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway Psmb1 Fzd6 Psmc2 Rac2 Prickle1 Psma7 Ap2a2 Ap2a1 Daam1 Rhoa Wnt5a Psmd12 Wnt5b Psmd11 Prkcb Vangl2 Psma6 Fzd4 Psmd8 Fzd7 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants Flt3 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 Cdc37 Erbin RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Ctla4 Il2 Foxp3 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants Flt3 Ptpn11 Pik3r1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer Tgfbr1 Smad4 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Hadha MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands Bdnf Hdac1 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay Xrn2 Exosc9 Exosc8 Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Pabpn1 Mphosph6 Ythdc1 Zc3h18 Dxo MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation Btrc Map2k1 Map3k8 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors Nkx2-5 Tbx5 Hipk1 Nppc ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway Gnai2 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME Ugt1a2 Slco1b2 Pon3 Pon1 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell Cbl Sh3kbp1 Stam2 Eps15 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD Oplah RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle Rhobtb3 Rab9 Ccne1 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination Polr2k Ercc3 Gtf2h2 Gtf2h3 Gtf2h5 Ubtf Taf1d AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification Mgst1 Ggt1 Mgst3 Dpep1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events Ffar1 Prokr1 Rgs2 Dgkb Lpar4 Lpar3 Lpar2 Lpar1 Prkch F2 Dagla Xcl1 Grp Ffar3 Bdkrb2 Bdkrb1 Rgs17 Chrm5 P2ry2 P2ry1 Tac3 Gprc6a Opn4 Nmb Plcb4 Dgkk Lpar5 Cck Ppan Prok1 Dgkz Nms Ltb4r2 Gast F2rl2 Gna14 Gng3 Gnb2 Gnb1 Gnb4 Avpr1b Cysltr1 Btk Trpc6 Pik3r1 Mgll Mapk1 Mchr1 Egfr GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs Prkag3 Camkk2 Prkag2 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS Lpcat4 Pla1a Plaat3 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation Rfc1 Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Pcna Rpa2 Gins2 Gins1 Mcm8 Cdc45 Pola2 Rpa3 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 Csf2ra Sftpa1 Sftpd INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation Ctnnb1 Gnb1 Grp Ffar1 Cdx2 Gip ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization Pik3r1 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress Cdk6 Cdkn2a TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins Tac3 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance Apoa1 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions Cdon RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle Dsp Vangl2 Picalm Rnd3 Kctd13 Ktn1 Ankrd26 Tmod3 Txnl1 Pkp4 Sema4f Lemd3 Tnfaip1 Ckap4 Srgap1 Srgap2 Cdc42bpa Daam1 Cdc42ep1 Tpm3 Nckap1l Stk38 Cdc37 Erbin Tex2 Plxna1 Wipf3 Bcr Stom Jag1 Arap2 Senp1 Syde2 Atp6ap1 Mcam Cpne8 Myo6 Abl2 Frs2 Nipsnap2 Pik3r1 Rasgrf2 Plxnd1 Cyba Cybb Nox3 Spata13 Nudc Aldh3a2 Mtr Rhof Rhod Arhgef15 Arhgef17 Arhgef11 Arhgdig Rac2 Noxa1 Emd Git1 Iqgap2 Iqgap3 Arhgap15 Diaph2 Diaph3 Stam2 Arhgap17 Efhd2 Sptan1 Usp9x Fam13b Fnbp1 Actn1 C1qbp Arhgap22 Abcd3 Baiap2l1 Ptpn13 Golga3 Vma22 Pkn3 Ophn1 Was Slitrk5 Slitrk3 Nhs Emc3 Csk Gopc Myo9a Prex1 Wasf3 Actc1 Wasf2 Dock7 Plekhg1 Farp1 Sh3bp1 Prag1 Abi2 Lbr Pkn2 Pkn1 Map3k11 Arhgap42 Racgap1 Cct7 Dock1 Rab7 Rhoa Ddx39b PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation Rhoa Irs2 Irs1 Pik3r1 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Pcsk7 Tmem258 Csnk2b Ganab Rpn2 Ctnnb1 Rpn1 Dad1 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk7 Kcnk6 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 Psmb1 Psmc2 Psma7 Btrc Psmd12 Psmd11 Psma6 Psmd8 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2bu2 Tnrc6a Setd1b H2ax Zfpm1 H2bc9 Gata1 H2bc7 H2bc8 Hdac1 H3c7 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism Akr1b1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer Smad4 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation Rhoa CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine H2bu2 H2ax H2bc9 H2bc7 Terf2 H2bc8 Terf2ip SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ctnnb1 Gnb1 Grp Ffar1 Cdx2 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR Adam17 Csk Cbl Sh3kbp1 Stam2 Eps15 Gab1 Areg Egfr Ptpn11 Pik3r1 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling Ptk6 Egfr GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation F10 Dph3 Drg1 Dph5 F2 F9 Dph6 Zc3h15 Arsj Arsi Etf1 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes Ctbp1 Tcf7l1 Hdac1 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade F2 C1qb C1rb Cr2 Cpn1 C7 C9 Cd46 Cpb2 Cfb C1qc C1qa C3ar1 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation Fgf7 Polr2k Polr2g Fgf22 Gtf2f1 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function H2bu2 Psmb1 Pcsk7 Psmc2 Tcf3 Ctnnb1 Psma7 Strap Kdm1a Zmym2 Mphosph8 Mcrip1 Ganab Snai1 Pkm Rpn2 Klf9 Zbtb33 Twist2 Foxp2 Rpn1 H2bc9 H2bc7 H2bc8 Ctbp1 Rbbp7 Ezh2 H3c7 Tnrc6a Tmem258 Csnk2b H2ax Foxa2 Eps15 Mapk1 Psmd12 Mdm2 Psmd11 Hdac1 Banp Psma6 Dad1 Psmd8 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones H2bu2 Sap30 Rbbp7 Kdm1a Gatad2a H3c7 Sap30l H2bc9 Hmg20b H2bc7 H2bc8 Hdac1 Brms1 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling Mef2c Bach1 Ncoa6 Crtc3 Rai1 Nrip1 Crtc1 Apoa1 Tlr4 Apob Slc46a1 Ly96 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism Itpk1 Inpp1 Nup133 Itpkb Nudt11 Plcz1 Inpp5b Mtmr7 Ip6k2 Plcg2 Ip6k3 Plcb4 Nup205 Synj1 Nup107 Miox Inpp4a Plcd1 Sec13 Nup85 Plch2 Nup88 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells Epcam SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants Cdc37 Erbin Gab1 Egfr Pik3r1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere Rfc1 Pold4 Rfc5 Rfc3 Pola2 Stn1 Rfc4 Rfc2 Dscc1 Terf2 Pcna Terf2ip FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation Fgf22 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling Plcg2 Btk Pik3r1 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription Sod2 Ins2 Pck1 Akt3 Akt2 Npy Pcbp4 Gck Agrp G6pc1 Akt1 Nr3c1 Hdac1 Smad4 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint Psmb1 Psmc2 Psma7 Psmd12 Psmd11 Ccnb2 Psma6 Psmd8 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex Chmp6 Pik3r4 Iscu Chmp3 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) Parp2 Rfc1 Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Pcna Rpa2 Nthl1 Rpa3 Parg Polb DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation Erlin2 Zmym2 Bcr Pik3r1 Fgfr1op2 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer Areg Egfr BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis Dicer1 Ang Elac2 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism Igf1 Ins2 Enpep Cma1 Ero1b Ctnnb1 Cpe Gnb1 Cpb1 Inhbc Cpa3 Grp Ffar1 Cpb2 Rab27a Ctsg Myo5a Ace Cdx2 Cltrn Gip Anpep Exoc7 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling Jak1 Ebi3 Tyk2 Crlf1 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation Ing2 Nup133 Xrcc4 Mitf Wrn Npm1 Pml Nrip1 Stag2 Smc3 Pias3 Ar Nr3c1 Herc2 Xpc Vdr Rara Ctbp1 Senp1 Pcgf2 Nsmce1 Smc6 Satb2 Pcna Nsmce4a Nop58 Top2b Nup205 Nup107 Sec13 Cbx4 Satb1 Bmi1 Mdm2 Hdac1 Nup85 Phc3 Nup88 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR Hsp90b1 Lgmn Unc93b1 Cnpy3 Tlr7 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis Pdcd6ip Peli1 Cdc37 Birc3 Tnfrsf10b Birc2 Fas Ube2l3 Traf2 Ripk1 Itch TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade Jun Mapk14 Map3k8 Mef2c Ppp2r5d Btrc Ube2v1 Nod1 Ripk2 Btk Nkiras1 Fgb Nkiras2 Fga Peli1 Myd88 Usp14 Fgg S100a1 Irak1 Traf2 Tlr4 Ly96 Tab2 S100a9 Map2k1 Mapk1 Ecsit DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling Fgf22 Cbl Mapk1 Frs2 Ptpn11 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 Cbl Klb Fgf15 Mapk1 Gab1 Frs2 Ptpn11 Pik3r1 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle Tpm3 Git1 Txnl1 Map3k11 Myo9a Sptan1 Usp9x Pik3r1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle Edem2 Ganab Rad23b Rnf103 Rnf139 Edem3 Syvn1 Trim13 Uggt1 Uggt2 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions Myh10 Cdk5 Myh9 Sema5a Dpysl2 Dpysl3 Dpysl5 Plxnd1 Plxnb3 Sema7a Crmp1 Rhoa Plxna1 Cfl1 Arhgef11 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 Fgf7 Fgf22 Gab1 Frs2 Ptpn11 Pik3r1 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME Ugt1a2 Hsd11b1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis Mef2c Tcf3 Myog Ctnnb1 Myod1 Cdh4 Cdh2 Cdh15 Ctnna2 Ntn3 Mapk14 Cdon POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation Nup205 Nup133 Nup107 Sec13 Ahctf1 Rcc1 Nup85 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening Cacna2d1 Cacna1b DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling Akt3 Akt2 Cdc37 Akt1 Erbin Matk Egfr INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate D2hgdh L2hgdh TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 H2bu2 Psmb1 Cdk6 Psmc2 Auts2 Tcf3 Ldb1 Psma7 Zfpm1 Gata1 Setd1b Pml H2bc9 H2bc7 H2bc8 Prkcb Itch Ptpn11 Foxp3 Pbrm1 Ctla4 Rybp H3c7 Lifr Tnrc6a Csnk2b Myb H2ax Serpinb13 Cbx4 Csf2 Bmi1 Il2 Psmd12 Psmd11 Hdac1 Phc3 Psma6 Psmd8 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex Tab2 Tlr4 Ly96 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization Pml Usp7 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Dkk1 Wnt5a Kremen1 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol Trmt61a Tprkb Ctu2 Trp53rkb Trmt112 Pus3 Trmt10a Trmt13 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway Fanci Rpa2 Eme1 Ube2t Mus81 Fancb Fancc Dclre1a Fan1 Rpa3 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state Psmb1 Psmc2 Psma7 Gmnn Orc1 Orc2 Mcm8 Ube2c Fzr1 Anapc11 Ccne1 Anapc10 Psmd12 Anapc1 Rbx1 Psmd11 Psma6 Ccna1 Psmd8 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines Xcl1 Ccl22 Ccl20 Ccl2 Ackr4 Cxcl5 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling Fas REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription Hoxc8 Snai1 Ilf3 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Onecut3 Mamld1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases Ctnnb1 Mapk14 Nup107 Sec13 Ppp1cc Dsp Nup85 Vangl2 Picalm Rnd3 Kctd13 Ktn1 Nup133 Ankrd26 Tmod3 Txnl1 Pkp4 Sema4f Lemd3 Tnfaip1 Ckap4 Srgap1 Srgap2 Ppp2r5e Cdc42bpa Daam1 Ppp2r5d Cdc42ep1 Ppp2r5c Tpm3 Ppp2r5b Nckap1l Ppp2r5a Stk38 Cdc37 Erbin Tex2 Plxna1 Wipf3 Bcr Actr2 Actr3 Ar Prkcb Btk Stom Flna Jag1 Arap2 Senp1 Syde2 Atp6ap1 Mcam Myh10 Ska1 Cpne8 Ahctf1 Myo6 Abl2 Nf2 Dynll2 Frs2 Nipsnap2 Ptk2 Pik3r1 Rasgrf2 Plxnd1 Cyba Cybb Nox3 Arpc4 Spata13 Nudc Aldh3a2 Mtr Rhof Rhod Arhgef15 Arhgef17 Arhgef11 Arhgdig Nuf2 Rac2 Noxa1 Emd Dync1h1 Git1 Iqgap2 Iqgap3 Arhgap15 Diaph2 Diaph3 Stam2 Arhgap17 Efhd2 Dynll1 Sptan1 Usp9x Fam13b Dync1i2 Fnbp1 Actn1 Pik3r4 C1qbp Evl Arhgap22 Abcd3 Scai Baiap2l1 Ptpn13 Cenpa Golga3 Vma22 Pkn3 Ophn1 Was Nsl1 Slitrk5 Slitrk3 Nhs Emc3 Csk Gopc B9d2 Myo9a Rps27 Prex1 Wasf3 Actc1 Wasf2 Dock7 Taok1 Plekhg1 Farp1 Sh3bp1 Prag1 Abi2 Cenpm Lbr Pkn2 Cenpi Pkn1 H2ax Map3k11 Cenpf Kif18a Arhgap42 Kif2c Klc2 H2bu2 Men1 Racgap1 Kdm1a Cct7 Dock1 Rab7 Rhoa H2bc9 Cfl1 H2bc7 H2bc8 Ddx39b Myh9 H3c7 S100a9 Mapk1 Pin1 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine Tomt Comt Maoa HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors Fshr Tshr NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters H2-Q10 Atp6v1h Ap1s3 Ap2a2 Ap2a1 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD Ahcy LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux Tnrc6a Apoc2 Eepd1 Kdm1a Kdm1b Kdm3a Apoc1 Apoe NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown Nup133 Emd Nek9 Nek6 Lemd3 Ccnb2 Nup205 Nup107 Cnep1r1 Sec13 Lpin1 Nup85 Prkcb Nup88 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling Cbl Mapk1 Ptpn11 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance Tuba1a Kif24 Cdk5rap2 Sclt1 Cep250 Sdccag8 Dync1h1 Dynlt2b Ift43 Cep78 Pcm1 Ift81 Gmnn Ift56 Dctn2 ATP6 Cep164 Ssna1 Cpap Tubg1 Dynll1 Mapk14 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Polg2 Csnk1d Twnk Esrra Ift52 Gmnc Micos10 Crtc1 Tfb2m Immt Mcidas Ccno Ift140 Mtx2 Dnajc11 Ift122 Mterf1b B9d2 Myb Hcfc1 Tfdp1 Mef2c Ncoa6 Crtc3 Sod2 Camk4 Ppargc1b Prkag2 Idh2 Dynll2 Hspa9 Tnrc6a Prkag3 Tctn3 Arl6 Pkd2 Mchr1 Bbs7 Rab11a Nedd1 Ahi1 Actr1a Exoc7 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily H2bu2 Fam124b Chd6 Igf2 Ctnnb1 H2ax Nqo1 H2bc9 H2bc7 H2bc8 Axin2 H3c7 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis Paics Ppat G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation Gng3 Gnb2 Gnb1 Gnb4 Gna14 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation Chp1 Hmmr Slc9a1 Hexb Cemip Hyal3 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage Gsdmd Casp3 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules Plcg2 Evl Itk Was Cd3g ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation Fga Psmb1 Psmc2 Myd88 Fgg Psma7 Cd207 Itgav Sec22b Sec61a2 S100a1 Tlr4 Ly96 Cyba Cybb H2-Q10 S100a9 Psmd12 Psmd11 Psma6 Btk Fgb Psmd8 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound Myh9 Kcnmb1 Rdx Pjvk Xirp2 Eps8 Pclo Sptan1 Kcnn2 Strc Cib2 Cdh23 Chrna9 Myo7a Otof Tprn Ripor2 Slc17a8 Atp2b1 Capza1 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 Psen2 Tnrc6a Tcf3 Myog Arrb1 Myod1 Tgfb2 Tgfbr1 Smad4 Rara AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade F10 F11 F2 F9 Serpine2 Ano6 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) Egr1 Mef2c Ppp2r5d Trib1 Cdk5 Id4 Tph1 Mapk1 Mapk14 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs Cbl Strap Itgav Tgfb2 Tgfbr1 Ppp1cc Ppp1r15a Smad4 Usp15 Mtmr4 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling Akt3 Akt2 Akt1 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 Galm EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids Cyp4f14 Cyp4f40 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling Myd88 Ube2v1 Irak1 Tlr7 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation Ins2 Irs2 Irs1 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption Slc5a1 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism Gaa Nhlrc1 Agl Pgm1 Pygl Pygm Ppp1r3c Pygb MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a St3gal4 St6galnac3 St3gal1 St6gal1 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins Exo1 Tcf3 Dync1h1 Rfc5 Rfc3 Dctn2 Rfc4 Rfc2 Exosc9 Dynll1 Exosc8 Ctr9 Dync1i2 Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Mphosph6 E2f7 E2f8 Rfc1 Ctsa Ell Polr2g Myb Ctsf Kif18a Ctsh Taf11 Aff4 Kif2c Taf13 Cd84 Taf12 Tnfsf13b Supt6 Gtf2f1 H2-Oa Klc2 Capza1 Icosl Batf Sh2d1a Actr10 Il21 Maf Mllt3 Racgap1 Ssrp1 Apex2 Polh Taf7 Taf5 Taf2 Cr2 Mad2l2 Rev1 Polr2k Ncoa6 Rab7 Dctn1 Icos Myh9 Ctnnbl1 Pcna Dynll2 E2f2 Actr1a DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) Sv2a SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy Tbk1 Tomm6 Dync1h1 Vdac3 Tomm7 Atg5 Prkag2 Vdac1 Dynll1 Dynll2 Dync1i2 Csnk2b Prkag3 Ube2v1 Epas1 Plin2 Ube2l3 Mfn1 Mfn2 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress Nup133 Dnajc7 Dnajc2 Hspa12b Bag3 Hspa14 Mlst8 Camk2g Hspa4l Camk2d Ccar2 Camk2b Camk2a Akt1s1 Rpa2 Rpa3 Fkbp4 Bag2 Hspa9 Nup205 Nup107 Sec13 Mapk1 Nup85 Nup88 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death Ripk1 Tlr4 Ly96 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle Actn1 Tmod3 Txnl1 Stk38 Cdc37 Cct7 Myo6 Ddx39b LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer Tgfbr1 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP Tnfrsf10b Fas Traf2 Ripk1 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling Apoc2 Apoc3 Apoa1 Apoa2 Apoe Apob Apoa4 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein Npm1 Nup205 Nup133 Nup107 Sec13 Rcc1 Nup85 Nup88 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing Hnrnpr Sugp1 Polr2k Phf5a Srrm2 Prpf6 Prpf3 Snrnp27 Ppig Cactin Ppih Pnn Ccdc12 Snrpa1 Prpf40a Ddx39b Dhx38 Rbmx2 Prpf8 Hnrnpa2b1 Nsrp1 Wbp11 U2af1l4 Srsf10 Prpf4b Pqbp1 Prpf18 Cwf19l2 Xab2 Snrpc Sf3b6 Ctnnbl1 Prpf38a Ppil2 Snrpn Steep1 Dhx35 Cherp Lsm2 Lsm8 Ppwd1 Polr2g Isy1 Puf60 Ppil4 Hnrnpa1 Ppil1 Gtf2f1 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation Cbl Sh3kbp1 Stam2 Eps15 Areg Egfr TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F12 F2 Klkb1 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling Nkiras2 Tbk1 Usp14 Birc3 Jun Irak1 Birc2 Traf2 Ripk1 Mapk14 Tlr4 Map3k8 Ly96 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ripk2 Nkiras1 Ptpn11 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis Psmb1 Psmc2 Erlin2 Psma7 Erlin1 Psmd12 Psmd11 Psma6 Psmd8 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly Ndor1 Nubp1 Rtel1 Ciao2b MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism EG433182 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia Nmral1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2bu2 Rbbp7 Ruvbl1 Mis18a Npm1 Rsf1 Cenpm Cenpi H2ax Cenpa H2bc9 H2bc7 H2bc8 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation Fgfr3 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis Plcg2 Ahcyl1 Prkar2a Prkar1a Prkacb Cd3g DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases Psmb1 Psmc2 Psma7 Kdm1b Hcfc1 Ruvbl1 Usp15 Bard1 Tgfbr1 Psmd12 Psmd11 Psma6 Psmd8 Yy1 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants Cdc37 Erbin Gab1 Egfr Pik3r1 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling Jak1 Tyk2 Ifna16 Ptpn11 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO Slit3 Slit1 Dcc TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors Prkcb Ap2a1 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Hmmr Csnk1d Nedd1 Actr1a TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) Syt2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding Bloc1s1 Bloc1s3 Tbc1d8b Dnajc6 Bloc1s4 Ap1s3 Tpd52l1 Rab5c Ap3b1 Fth1 Sort1 Ap1g2 Hip1r Arrb1 M6pr Gns Picalm DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) Slc6a5 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis Pck1 Nrip1 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels Kcnip3 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors Nuf2 Rac2 Noxa1 Ctnnb1 Dync1h1 Iqgap2 Iqgap3 Diaph3 Dynll1 Mapk14 Dync1i2 Pik3r4 Evl Scai Cenpa Pkn3 Was Nsl1 Gopc B9d2 Rps27 Wasf3 Wasf2 Taok1 Abi2 Cenpm Pkn2 Cenpi Nup107 Pkn1 H2ax Sec13 Cenpf Kif18a Kif2c Ppp1cc Klc2 Nup85 H2bu2 Men1 Ktn1 Nup133 Kdm1a Srgap2 Ppp2r5e Daam1 Ppp2r5d Ppp2r5c Ppp2r5b Rhoa Nckap1l Ppp2r5a Wipf3 H2bc9 Cfl1 Actr2 H2bc7 Actr3 Ar H2bc8 Prkcb Btk Flna Myh10 Myh9 Ska1 Ahctf1 Nf2 Dynll2 H3c7 Ptk2 Cyba Cybb Nox3 Arpc4 Nudc S100a9 Mapk1 Rhod Pin1 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family Psmb1 Psmc2 Ctnnb1 Akt3 Akt2 Erlin2 Psma7 Jak1 Erlin1 Stt3b Mlst8 Rpn2 Mapkap1 Rpn1 Akt1 Btrc Rbx1 Ptpn11 Magt1 Csk Btla Tmem258 Tcf7l1 H2ax Icosl H2bu2 Jun Mib2 Map3k8 Pik3r5 Ppp2r5e Ppp2r5d Ppp2r5c Pdcd1lg2 Ppp2r5b Map3k14 Ppp2r5a Epas1 Tead4 H2bc9 H2bc7 H2bc8 Cd3g Ctla4 Rbbp7 Trib3 Pik3cg Brd4 Prkag2 Tead3 Tead2 Ezh2 H3c7 Pik3r1 Tnrc6a Csnk2b Prkag3 Psmd12 Psmd11 Psma6 Dad1 Psmd8 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Ffar1 Gip TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway Psmb1 Psmc2 Psma7 Tnfrsf1a Birc3 Birc2 Traf2 Map3k14 Tnfsf15 Tnfsf13 Tnfrsf9 Lta Btrc Eda2r Tnfrsf13b Tnfsf13b Psmd12 Tnf Psmd11 Psma6 Psmd8 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation Psmb1 Psmc2 Psma7 Psmd12 Psmd11 Psma6 Psmd8 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand Fga Fgg Gsdmd S100a9 Gsdme S100a1 Tlr4 Apob Fgb Tlr7 Ly96 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins Defb23 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions Cntn6 Ank1 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes Mbtps1 Creb3 Dcstamp Creb3l1 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders Slc7a7 Slc35a1 Nup133 Slc26a2 Slc5a1 Slc22a12 Slc22a18 Heph Slc6a2 Slc6a5 Gck Nup205 Nup107 Slc12a6 Slc20a2 Slc17a8 Sec13 Slco1b2 Slc29a3 Slc40a1 Avpr1b Nup85 Nup88 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling Rhoa Myh10 Myh9 Arhgef11 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis Mogat1 Gpat2 Lpin1 Dgat2 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin Maoa SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III Tubal3 Tuba1a Chmp6 Tubb2a Chmp3 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1a SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 Jag1 Adam17 Hdac5 Ccnc Cdk8 Mib2 Mamld1 Hes5 Psen2 Arrb1 Mib1 Jag2 Rbx1 Hdac1 Itch AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C Psmb1 Psmc2 Psma7 Ube2c Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Psmd8 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer Npm1 Icos Gzmb Bcl2a1d Foxm1 Mapk1 Hdac1 Rbx1 Prf1 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism Upp2 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle Sdhaf1 Lyrm4 Sdhc Idh2 Sdhb NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects Ada PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation Ell Polr2k Polr2g Ssrp1 Gtf2f1 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway Rdh16f2 Adh4 Crabp1 Dhrs9 Rdh14 Sdr16c5 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching Slit1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest E2f7 Ccne1 E2f8 Pcbp4 Ccna1 Zfp385a DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function Rpa2 Rad9a Exo1 Bard1 Rbbp8 Palb2 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Wrn NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription Egr1 Trib1 Cdk5 Id4 Tph1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Ptk6 Dock1 Rhoa Crk IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Rpa2 Exo1 Pold4 Rpa3 Pcna RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle Racgap1 Mcam Myo9a Iqgap3 Prex1 Diaph3 Actc1 Pik3r1 Daam1 Pkn2 Pkn1 Erbin Bcr Pkn3 Ophn1 Arhgef17 Arhgef11 Arhgdig Stom REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL Cbl Blnk Crk Pik3r1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions Ppl Btn1a1 Xdh DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation Pola2 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death Pdcd6ip Peli1 Cdc37 Birc3 Tnfrsf10b Birc2 Fas Ube2l3 Traf2 Ripk1 Itch INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling Sod2 Hnrnpa2b1 Taldo1 Jak1 Ebi3 Tyk2 Crlf1 Hspa9 Ca1 Il12rb1 Il12rb2 Cfl1 Il12b Pdcd4 Capza1 Il12a Snrpa1 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway Map2k2 Map2k1 Mapk1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade Ins2 Trib3 Akt2 Klb Fgf15 Gab1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Irs2 Mapk1 Ptpn11 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Nedd1 Actr1a VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism Slc23a2 Cyb5a Slc23a1 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 Bdnf DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 Gab1 Frs2 Ptpn11 Pik3r1 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors Apob MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a St3gal4 St6galnac3 St3gal1 St6gal1 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism Slc52a2 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Bcl2l14 Rabggta Perp ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism Pck1 Adal DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling Jak1 Ebi3 Tyk2 Il12rb2 Il12a INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells Ctnnb1 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Cdk6 Tfdp1 Ccne1 E2f2 E2f3 Tfdp2 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis Slc35d2 B3gnt2 St3gal4 Chst2 St3gal6 St3gal1 B4galt6 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors Pabpc1 Pabpn1 Eif4b Eif4e ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate Phyh Slc25a17 Hacl1 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle Txnl1 Stk38 Cct7 Myo6 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin Psmb1 Psmc2 Psma7 Mcm8 Orc1 Orc2 Psmd12 Psmd11 Rbx1 Psma6 Ccna1 Psmd8 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol Noc4l Pdcd11 Imp4 Trmt112 Dcaf13 Utp6 Rrp9 Nop58 Utp14a Ddx49 Rcl1 Nop10 Utp11 Dkc1 Bms1 Ddx52 Nat10 Wdr75 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB Prkar2a Prkar1a Prkacb REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity Psmb1 Psmc2 Psma7 Psmd12 Mdm2 Psmd11 Psma6 Psmd8 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli Rpl4 Hif3a Mink1 Castor1 Serp1 Rpl39 Limd1 Ramp2 Rpl7 Cacna1h Itgav Map3k5 Yif1a H1f2 H1f3 Cdkn2c Szt2 Mlst8 Ern1 Klhdc3 Ppp1r15a Mt2 Mt4 Rpa2 Map4k4 Hmga2 Flt4 Pecam1 Rpl22 Gpx7 Mapkap1 Dnaja4 Rpa3 Sh3bp4 Nrip1 Fkbp4 Higd1c Syvn1 Mtf1 Tkt Akt1s1 Dctn1 Rpl18 Ar Nr3c1 Sec31a Bag2 Dynll2 Ptk2 Cyba Csnk2b Cybb Cox6a1 Cox6a2 E2f2 Actr1a Kdr Dync1h1 Ajuba Dctn2 Dynll1 Dync1i2 Btrc Me1 Slc46a1 Dnaja2 Pkn2 H2ax Cbx4 Bmi1 Phc3 Cxxc1 H2bu2 Taldo1 Arnt Gfpt1 Mbtps1 G6pdx Mef2c Hsp90b1 Ncoa6 H2bc9 H2bc7 H2bc8 Rbbp7 Trib3 Apoa1 Ezh2 H3c7 Cdkn2b Chac1 Atox1 Psmd12 Psmd11 Psma6 Psmd8 Psmb1 Cdk6 Psmc2 Ctnnb1 Psma7 Exosc9 Dcp2 Exosc8 Camk2g Camk2d Mapk14 Camk2b Exosc4 Camk2a Dis3 Exosc6 Exosc1 Exosc2 Akt1 Prkar2a Crtc1 Prkar1a Prkacb Rbx1 P2ry2 Nup205 Nup107 Palb2 Sec13 Nqo1 Nup85 Nup88 Nup133 Tcirg1 Ppp2r5b Crtc3 Atp6v1a Rai1 Atp6v0d2 Atp6v1f Phb2 Idh1 Hspa9 Tnrc6a Ube2c Fzr1 Anapc11 Anapc10 Cdkn2a Anapc1 Txnrd1 Rps11 Akt3 Akt2 P2rx7 Chd6 Rps25 Rps26 Trim21 Rps27 Rps21 Areg Ccne1 Capza1 Actr10 Gng3 Gnb2 Gnb1 Gnb4 Dnajc7 Dnajc2 Jun Hspa12b Terf2 Bag3 Hspa14 Terf2ip Hspa4l Ccar2 E2f3 Tfdp2 Tfdp1 Stap2 Ptk6 Eif2s3x Eif2s2 Atp6v1h Epas1 Creb3 Dcstamp Creb3l1 Sod2 Bach1 Slc7a11 Trpv4 Lamtor2 Tlr4 Ly96 Samtor Preb Lonp1 Nprl2 H13 Ppp2r2a Mapk1 Mdm2 Asf1a H1-5 Wdr59 Apob Depdc5 Ccna1 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME Acsm5 Ugt2a1 Glyatl3 Cyp2d22 Ugt2a2 Cyp2c65 Glyat Ugt1a2 Ugt2b1 Ces2h Acsm4 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease Fgf7 Polr2k Polr2g Fgf22 Gab1 Gtf2f1 Frs2 Pik3r1 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids Nuf2 Psmb1 Psmc2 Nup133 Dync1h1 Psma7 Dynll1 Dync1i2 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cenpa Wapl Stag2 Smc3 Nsl1 B9d2 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Ube2c Nudc Kif2c Ppp1cc Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Nup85 Psma6 Psmd8 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs Dync1h1 Dnaja2 Dctn2 Dynll1 Dynll2 Dync1i2 Dnaja4 Dctn1 Fkbp4 Ar Nr3c1 Capza1 Actr1a Actr10 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines Pbrm1 Prmt7 Rbbp7 H2ax H3c7 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins Pkp1 Ctnnb1 Casp3 Dsp DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response Psmb1 Kdm4b H2bu2 Psmc2 Eya1 Psma7 Bard1 H2ax Eya3 H2bc9 Apbb1 H2bc7 Psmd12 H2bc8 Rbx1 Psmd11 Psma6 Herc2 Psmd8 Ddb1 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation Ahcyl1 Ppp3cb INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage Casp3 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited Tnfrsf10b Fas Traf2 Ripk1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 Tnfrsf10b Fas Traf2 Ripk1 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis P2rx7 Trpc6 Atp2b2 P2rx4 Atp2b1 Slc8a1 Slc8a2 Orai2 Stim1 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER Rpa2 Rfc1 Pold4 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport Psmb1 Psmc2 Erlin2 Psma7 Erlin1 Apoa1 Eif2s3x Eif2s2 Abcd3 Abcb6 Psmd12 Abcf1 Psmd11 Psma6 Abca2 Psmd8 Abca8b RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry Gpc3 Gpc2 Gpc4 Sdc3 Egfr Rab5c Tlr4 Ly96 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease Dcp2 Lsm2 RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs Flna Myh10 Myh9 Nf2 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) P2rx7 Pycard Sugt1 Casp1 Gsdmd C3ar1 P2rx4 Ctsg SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA Gpat4 Gpat2 Lpcat4 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Cdk11b Tubgcp5 Tubgcp4 Nedd1 Actr1a FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm Ctnnb1 Foxa2 Smad4 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se Cbs Gnmt Ahcy ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants Flt3 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K Vkorc1l1 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib Cdc37 Erbin MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels Hdac1 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Cyp7a1 Cyp7b1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts Cyp7a1 Hsd17b4 Abcd3 Cyp39a1 Amacr Slc27a5 Cyp7b1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 Casp3 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk9 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 Fgf22 Gab1 Frs2 Ptpn11 Pik3r1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils Bmp1 Tll1 Pxdn Loxl1 Loxl3 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) Fga Csk Adra2a Fgg F2 Apbb1ip Akt1 Rap1a Crk Fgb Ptk2 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R Igf1 Igf2 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA Psmb1 Psmc2 Psma7 Rfc5 Rfc3 Gmnn Orc1 Rfc4 Orc2 Rfc2 Rpa2 Rpa3 Rbx1 Rfc1 Pold4 Pcna Gins2 Gins1 Mcm8 Cdc45 Pola2 Ube2c Fzr1 Anapc11 Ccne1 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2bu2 Pkn1 H2ax Kdm1a H2bc9 H2bc7 Ar H2bc8 H3c7 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH Hdac5 H2bu2 Psmb1 Psmc2 Psma7 Ccnc St3gal6 Jun Mib2 Mamld1 Elf3 Notch3 E2f3 Tfdp2 Tfdp1 Psen2 Flt4 Akt1 Mib1 H2bc9 H2bc7 H2bc8 Jag2 Rbx1 Itch Adam17 Jag1 Wwc1 St3gal4 Cdk8 Gzmb Mdk Hes5 H3c7 Tnrc6a Plxnd1 Arrb1 H2ax Psmd12 Psmd11 Hdac1 Egfr Psma6 Psmd8 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis Rhoa INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling Il21 Il21r Jak1 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions Actn1 Magi2 Sptan1 Pik3r1 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud Hoxd11 Eya1 Gdnf Six2 Hoxa11 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA Hadha SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin Igf1 Ins2 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation Hif3a Psmb1 Psmc2 Cop1 Psma7 Kctd7 Fbxl20 Btbd1 Btrc Epas1 Fbxw8 Asb16 Rbx1 Fbxo21 Ddb1 Rbbp7 Fbxo7 Dcaf10 Cops8 Ccdc22 Klhl25 Cops7a Commd4 Klhl20 Cops7b Neurl2 Klhl2 Dcaf13 Nae1 Spsb2 Dcaf4 Fbxl14 Ankrd9 Spsb1 Fbxl16 Wsb2 Dda1 Fbxl19 Dcun1d3 Asb7 Palb2 Psmd12 Psmd11 Psma6 Psmd8 Fbxw4 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 Stap2 Ptk6 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production Ggt1 Cysltr1 Dpep1 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins Tmem258 Magt1 Rpn2 Rpn1 Nmt1 Stt3b Apoa1 Kpna4 Dad1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport Sdhaf1 Pcx ATP6 Ndufa3 Ndufa7 Coa3 Sco1 Ndufa12 Ranbp9 Me1 Nnt Ndufb2 Higd1c Ndufb6 Ndufb8 Timm21 Ogdh Higd2a Ndufs2 Ndufs8 L2hgdh Slc25a27 Ecsit Hscb Uqcrc2 D2hgdh Sdhc Sdhb Ndufaf2 Ndufaf1 Slc25a18 Bcs1l Idh3b Cox20 Rmnd5b Mdh1 Mdh2 Uqcrfs1 Lyrm4 Vdac1 Idh2 Lyrm2 Tmem186 Hspa9 Cox16 Uqcc6 Cox6a1 mt-Cytb Cox6a2 mt-Nd4 mt-Nd5 Mpc2 mt-Nd6 Rab5if Trap1 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome Casp1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes Sec31a Serp1 Ppp2r5b Gfpt1 Dctn1 Syvn1 Preb Yif1a Klhdc3 Cxxc1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade Nkiras2 Tbk1 Usp14 Birc3 Jun Irak1 Birc2 Traf2 Ripk1 Mapk14 Map3k8 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ripk2 Nkiras1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes Apoc2 Mbtps1 Apoa4 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair Nthl1 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants Kit PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 Klb Fgf15 Gab1 Frs2 Ptpn11 Pik3r1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination Polr3d Polr2k Polr3f Polr3k Polr3a Ssb SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism Serinc4 Serinc2 Serinc3 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription Tfdp1 Tyms Cdc45 Orc1 E2f6 Ccne1 Pcna Hdac1 Ccna1 Tfdp2 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation Hgf DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) Slc6a2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis Sod2 Mterf1b Camk4 Ppargc1b Hcfc1 Prkag2 ATP6 Idh2 Mapk14 Hspa9 Mef2c Ncoa6 Prkag3 Polg2 Crtc3 Twnk Esrra Crtc1 Micos10 Tfb2m Immt Mtx2 Dnajc11 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates Exo1 Eme1 Bard1 Mus81 Rbbp8 Palb2 Wrn FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids Cyp4f14 Cyp2d22 Cyp4f40 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Treml1 Siglec1 Cd300a Nectin2 Cd200r1 Siglec12 H2-Q10 Klrb1 Crtam Jaml Icam5 Lilra5 Cd3g Sh2d1a DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential Kcnk9 Kcnk7 Kcnk6 Kcnk4 Kcnk2 Kcnk10 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency Pcx DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles Fmo2 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6pc1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange Rpa2 Rad9a Exo1 Bard1 Rbbp8 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Wrn CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type Cyp2s1 Arnt2 Arnt Por Cyp4f40 Cyp7a1 Cyp4f14 Cyp2d22 Cyp39a1 Cyp2c65 Cyp11b1 Cyp11b2 Cyp7b1 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea Myh9 Kcnmb1 Rdx Pjvk Xirp2 Eps8 Pclo Sptan1 Strc Cib2 Cdh23 Myo7a Otof Tprn Ripor2 Slc17a8 Atp2b1 Capza1 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling Mras Ppp1cc BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) Ltc4s PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism Ranbp9 Mpc2 Pcx Me1 Vdac1 Rmnd5b DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism Chp1 Pfkfb2 Pck1 Glce Pfkfb1 Chsy3 Eno2 Slc26a2 Lalba Pcx Cemip Fbp2 Fam20b Ndst3 Hpse B3gnt2 Sdc3 Galm G6pc1 Prkacb Gns Abo Gpc3 Slc35b3 Gpc2 Gaa Gpc4 Dera St3gal4 St3gal1 Pgm2 B3galt2 Nup205 Gpi Pgm1 Nup107 Hmmr Sec13 Akr1b1 Nup85 Hs3st2 Nup88 Rpe Taldo1 Nup133 Man2b1 Chst2 B4galnt2 St3gal6 Hexb Cspg5 Hyal3 G6pdx Shpk Pfkp Tkt Ppp2r5d EG433182 Has3 Xylt2 Pygb Nhlrc1 Fut9 Agl Pygl Slc9a1 Pygm Hs6st2 Cryl1 Slc35d2 Gck Slc37a4 B4galt6 Ppp1r3c Pfkfb4 Pfkfb3 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes Apex2 Rfc1 Polh Rfc5 Rfc3 Rfc4 Rfc2 Pcna Mad2l2 Rev1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex Tfdp1 Pcna Hdac1 Tfdp2 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants Flt3 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D Gns CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine Cbs GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) Psmb1 Psmc2 Psma7 Btrc Psmd12 Psmd11 Rbx1 Psma6 Psmd8 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation Fga Itm2b H2bu2 Ins2 Nat8 Sorl1 Tspan33 Apoa1 Usp9x Apoe H3c7 Apoa4 H2ax Gga3 H2bc9 H2bc7 H2bc8 Apcs Tspan15 Odam LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling Mttp Apob FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases Flt3 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex Ube2b Rpa2 Rfc1 Pold4 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna Rbx1 Ddb1 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins Psmb1 Psmc2 Psma7 Ube2c Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization Col4a4 Col15a1 Col6a3 Col17a1 Col18a1 Col4a5 Col12a1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates Nme4 Tyms Nme1 Nme6 Rrm1 Txnrd1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling Ranbp10 Ranbp9 Hgf TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Tfdp1 Pcna Zfp385a Tfdp2 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling Trib3 Akt2 Klb Fgf15 Gab1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Irs2 Ptpn11 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism Slc22a13 Nmnat2 Slc25a51 Nudt12 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Ilk Parva CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Jak1 Strap Zmym2 Tyk2 Sptan1 Ilf3 Hoxc8 Actn1 Ganab Rpn2 Rpn1 Col17a1 Pals1 Ptpn11 Magi2 Tmem258 Nectin2 H2ax Eps15 Itgb4 Hdac1 Plec H2bu2 Pcsk7 Ilk Kdm1a Parva Nectin1 Cdh8 Nectin4 Cdh6 Birc2 Cdh3 Cldn23 Cdh19 Mphosph8 Sirpb1b Cdh13 Cdh12 Cadm2 Mcrip1 Pkm Cdh24 Snai1 Dock1 Cldn2 Klf9 Zbtb33 Zc3h12a Twist2 Foxp2 Tesk1 Sdk1 Fblim1 Parvb H2bc9 H2bc7 Ang Cldn1 H2bc8 Flna Ctbp1 Rbbp7 Ezh2 H3c7 Pik3r1 Ptk2 Cdh11 Tnrc6a Csnk2b Cdh4 Cdh2 Foxa2 Cdh15 Mapk1 Psmd12 Mdm2 Psmd11 Banp Psma6 Dad1 Psmd8 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A F10 F2 F9 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins Alg8 Alg3 Neu1 Ctsa RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 Ktn1 Rhoa Klc2 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 Rpa2 Rad9a Exo1 Bard1 Rbbp8 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Wrn VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium Arl6 Mchr1 Bbs7 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs Abi2 Nckap1l Arpc4 Wasf3 Wipf3 Wasf2 Actr2 Mapk1 Actr3 Was Btk Ptk2 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events Chmp6 H2bu2 Nup133 H3c7 Ubap1 Chmp1a Nup205 Nup107 Tsg101 Sec13 Vps25 Mvb12a H2bc9 H2bc7 H2bc8 Nup85 Chmp3 Nup88 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins Nup205 Nup133 Nup107 Sec13 Pias3 Pcna Nup85 Top2b Nup88 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis Mef2c Nkx2-5 Ldb1 Ctnnb1 Tbx5 Mesp1 Tbx1 Smad4 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades Tbk1 Gsdmd Birc3 Jun Birc2 Mapk14 Map3k8 Tlr7 Mef2c Hsp90b1 Plcg2 Pik3r4 Ppp2r5d Btrc Ube2v1 Nod1 Tasl Ly86 Itgam Ripk2 Btk Irf5 Nkiras1 Ptpn11 Fgb Nkiras2 Fga Peli1 Myd88 Usp14 Lgmn Fgg S100a1 Irak1 Traf2 Ripk1 Cnpy3 Tlr4 Ly96 Tab2 Unc93b1 S100a9 Gsdme Rbsn Map2k1 Mapk1 Ecsit Apob DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h Alg8 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 Cyp7b1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation Tfb2m OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation H2bu2 Psmb1 Psmc2 Psma7 Gmnn Orc1 Orc2 Rpa2 Rpa3 H2bc9 H2bc7 H2bc8 H3c7 H2ax Mcm8 Cdc45 Pola2 Ube2c Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Psmd8 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation Akt1s1 Camk2a Fkbp4 Mlst8 Camk2g Camk2d Camk2b TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins Edem2 Magt1 St3gal4 St6galnac3 Mgat4a Mgat4b St3gal1 Stt3b St6gal1 Srpk1 Zdhhc3 Tmem258 Ganab Rpn2 Zdhhc9 Rpn1 Golga7 Mgat5 Dad1 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 Irs2 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants Map2k2 Map2k1 Mapk1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily H2bu2 Ssrp1 Tcf3 Myog Myod1 Sf3b6 Snrpn Ctr9 Cherp H3c7 Phf5a H2ax Puf60 H2bc9 H2bc7 H2bc8 Snrpa1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport Atp6ap1 Tcirg1 Fth1 Heph Atp6v1a Atp6v0d2 Atp6v1h Atp6v1f Slc40a1 Atp6v0a4 Aco1 Slc46a1 Ftmt TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors Kdm5b TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation Nkiras2 Traf2 Rigi Nkiras1 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psmb1 Psmc2 Psma7 Ube2c Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle Gopc Git1 Iqgap3 Prex1 Cpne8 Diaph3 Arhgap17 Srgap2 Fnbp1 Cdc42bpa Cdc42ep1 Rab7 Ophn1 Stom RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription Fanci Ing2 Exo1 Meaf6 Fancc Bcl2l14 Rfc5 Gls Rfc3 Rfc4 Rfc2 Prelid1 Dyrk2 Mlst8 Wrn Prelid3a Zfp385a Med8 Npm1 Rpa2 Casp2 Rbbp8 Pml Mapkap1 Ttc5 Rpa3 Hipk1 Pip4k2c E2f7 E2f8 Higd1c Pbrm1 Kdm5b Gpi Kit Ar Prkcb Nr3c1 Vdr Rara Ints7 Ints2 Ints3 Snapc1 Snapc2 Nabp2 IntS13 Ints11 Rprd2 Csnk2b Cox6a1 Cox6a2 Egfr Cpap Ctr9 Usp9x Nudt21 G6pc1 Lbr H2ax Med23 Med24 Cbx4 Bmi1 Phf20 Phc3 Hdac1 Yy1 H2bu2 Hdac5 Gls2 Men1 Maf Arnt Ccnc Zfp141 Med16 Med17 G6pdx Zfp454 Znf382 Mef2c Polr2k Zfp157 Nkx2-5 Zfp398 Setd1b Zfp712 Twist2 Gtf2h2 Zfp707 Zfp248 Gtf2h3 Zfp872 Gtf2h5 Tead4 Esrrb H2bc9 Zfp740 H2bc7 Zfp184 H2bc8 Zkscan5 Zfp746 Foxp3 Krba1 Med31 Ins2 Camk4 Ercc3 Ctla4 Rbbp7 Znf2 Ppargc1b Zfp28 Znf583 Rybp Cdk8 Pcgf2 Cdk5 Npy Zfp324 Zfp11 Satb2 Ucma Gatad2a Tead3 Ezh2 Tead2 H3c7 Zfp605 Atad2 Lifr Zfp791 Agrp Cdkn2b Msx2 Zfp30 Serpinb13 Pvalb Zfp426 Zfp664 Csf2 Il2 Psmd12 Zfp51 Znf551 Psmd11 Psma6 Zfhx3 Psmd8 Smad4 Psmb1 Cdk6 Pck1 Psmc2 Auts2 Tcf3 Ctnnb1 Ldb1 Psma7 Zfp473 Kcnip3 Mybl2 Znf771 Znf641 Rbm14 Mobp Nrbp1 Dgcr8 Camk2g Apoe Camk2d Mapk14 Camk2b Zfp697 Camk2a Mga Tbx5 Pitx2 Zfp560 Zfp445 Akt1 Esrra Zfp202 E2f6 Rbx1 Itch Ell Polr2g Taf11 Taf13 Taf12 Gtf2f1 Arnt2 Ssrp1 Taf7 Taf5 Taf2 Ppp2r5c Jag1 Hnf4a Prkag2 Tnrc6a Brd2 Kctd1 Kctd15 Ube2c Fzr1 Anapc11 Anapc10 Cdkn2a Anapc1 Txnrd1 Akt3 Akt2 Ptpn11 Casp1 Irak1 Myb Tcf7l1 Tsc2 Aff4 Ccne1 Supt6 Mllt3 Zfpm1 Gata1 Jun Mamld1 Notch3 Tfdp2 Tfdp1 Pabpn1 Sod2 Trp53rkb Rabggta Tnfrsf10b Pou4f1 Fas Pcna Lamtor2 Pcbp4 Usp7 Perp Rffl Rad9a Bdnf Bard1 Gck Cradd Prkag3 Pidd1 Cnot7 Cnot6 Cnot9 Cdk12 Jmy Mapk1 Mdm2 Pin1 Banp Btg2 Ing5 Ccna1 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation Flt3 Ptpn11 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME Ggt1 Gstt1 Sult1e1 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np Hhat TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts Nup205 Nup133 Nup107 Sec13 Eif4e Nup85 Nup88 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 Pcbp4 Zfp385a FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Hmga2 H1f2 H1f3 Asf1a H1-5 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins Ubap1 Tsg101 Mvb12a DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 Nthl1 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes Bdnf Ins2 Arnt2 Arnt Cdk5 Mapk1 Mdm2 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation Ctla4 Trib3 Akt3 Pik3cg Akt2 Mlst8 Map3k8 Pik3r5 Pik3r1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Map3k14 Ppp2r5a Mapkap1 Akt1 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Sephs2 Rps21 Eefsec Rpl22 Secisbp2 Rpl18 Sepsecs Rps11 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis Rab7 Rnf213 Nos2 Sfpq Atp6v1h Coro1a Vps33b EG433182 Mapk1 Ctsg MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Hadha ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation Bmp1 Tll1 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle Git1 Iqgap3 Prex1 Cpne8 Diaph3 Nipsnap2 Pik3r1 Fnbp1 Cdc42bpa Cdc42ep1 Rab7 Ophn1 Was Stom STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 Psmb1 Psmc2 Cop1 Psma7 Psmd12 Phf20 Mdm2 Psmd11 Psma6 Psmd8 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus Nup133 Pop7 Pop4 Pop1 Rtcb Rpp21 AI597479 Rtraf Rpp14 Rpp40 Nup205 Nup107 Sec13 Nup85 Elac2 Nup88 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions Prnp Cacna1i Cacna1h Gdnf Col4a4 Col6a3 Col4a5 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 Klb Fgf15 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling Ins2 Atp6ap1 Atp6v1a Atp6v0d2 Atp6v1h Atp6v1f Atp6v0a4 Tcirg1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 Klb Fgf15 Gab1 Frs2 Ptpn11 Pik3r1 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation Psmb1 Psma7 Psma6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling Foxp3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion Hsd17b10 Yrdc Mto1 Trmt10c Prorp REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle Mfn1 Mfn2 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport Trappc4 Sec31a Rab1b Sec22b Areg Trappc10 Golga2 Gorasp1 Sec13 Csnk1d Ppp6c Preb Lman2 Sec22c Sec23ip Trappc6b Ankrd28 Trappc6a MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle Ptk6 Ccne1 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase Dkc1 Rtel1 Ppp6c Terf2 Ankrd28 Ruvbl2 Pif1 Ruvbl1 Terf2ip Ccna1 Nop10 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) Myd88 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate Slc25a10 Ethe1 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins Psmb1 Psmc2 Prickle1 Psma7 Wnt5a Psmd12 Psmd11 Vangl2 Psma6 Fzd4 Psmd8 Fzd7 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism Acer3 Sphk1 Hexb B4galnt1 Arsj Arsi St6galnac5 Smpd1 M6pr Ormdl1 Sgpp2 Cers6 Cers3 Ugt8 Cers2 Cerk Cers1 Ctsa Mfsd2b Asah1 Neu3 Psap B4galt6 Sgms2 A4galt Neu1 Kdsr DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance Rpl4 Psmb1 Psmc2 Ldb1 Rpl39 Psma7 Cacna1h Rpl7 Itgav Psen2 Pabpc1 Rpl22 Ranbp9 Prkar2a Akap5 Prkacb Rbx1 Hoxa2 Slit1 Msi1 Sema5a Col4a5 Lhx2 Etf1 Upf3a Gspt1 Col4a4 Col6a3 Ap2a2 Srgap1 Ap2a1 Srgap2 Rpl18 Plxna1 Actr2 Actr3 Myh10 Gdnf Abl2 Frs2 Ptk2 Pik3r1 Dpysl2 Dpysl3 Plxnd1 Dpysl5 Plxnb3 Prnp Csnk2b Cacna1i Sema7a Crmp1 Arpc4 Sh3kbp1 Irs2 Ppp3cb Dscaml1 Egfr L1cam Arhgef11 Rps11 Reln Dok6 Scn8a Sptbn4 Sptb Rgmb Git1 Rgma Shtn1 Epha5 Scn11a Ephb1 Ephb3 Ephb4 Cap2 Sptan1 Ablim3 Evl Ptpn11 Rps25 Rps26 Rps27 Rdx Gab1 Rps21 Mmp9 Myo10 Dcc Unc5c Slit3 Dock1 Rhoa Dok1 Cntn6 Cfl1 Ank1 Trpc6 Cdk5 Myh9 Map2k2 Map2k1 Mapk1 Psmd12 Epha4 Psmd11 Psma6 Psmd8 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins Pcgf2 Cbx4 Bmi1 Phc3 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization Kdr Trappc4 Itgav Tgfb2 Sntg2 Eln Tnn Fbln5 Actn1 Matn1 Lama2 Pecam1 Ddr1 Sdc3 Fbn2 Dtna Snta1 Col15a1 Lrp4 Capn15 Lamb2 Col17a1 Sspn Col18a1 Mfap5 Ctsg Sntb2 Col12a1 Sntb1 Klkb1 Sgcd Fgb Plg Sgcb Adam17 Fga Sgca Cma1 Fbn1 Mmp20 Capn9 Adamts1 Fgg Mmp12 Scube1 Mmp7 Casp3 Mmp17 Capn7 Mmp19 Col4a5 Prss2 Mmp9 Tmprss6 Mmp1a Bmp1 Spock3 Tll1 Capn10 Mmp10 Col4a4 Icam5 Serpinh1 Col6a3 Pxdn Itgb4 Loxl1 Ppib Loxl3 Plec Itgam CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance H2bu2 Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Terf2 Atrx Wrn Terf2ip Mis18a Rsf1 Polr2k Npm1 Rpa2 Rpa3 Cenpa Stn1 Dscc1 H2bc9 H2bc7 H2bc8 Rbbp7 Rfc1 Pold4 Pcna Ruvbl2 Ruvbl1 Nop10 Polr2g Dkc1 Cenpm Cenpi H2ax Pola2 Ppp6c Ankrd28 Pif1 Ccna1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade Tbk1 Birc3 Jun Birc2 Mapk14 Map3k8 Mef2c Plcg2 Ppp2r5d Btrc Ube2v1 Nod1 Ly86 Itgam Ripk2 Btk Nkiras1 Ptpn11 Fgb Nkiras2 Fga Peli1 Myd88 Usp14 Fgg S100a1 Irak1 Traf2 Ripk1 Tlr4 Ly96 Tab2 S100a9 Map2k1 Mapk1 Ecsit BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Akt1 Exosc9 Dcp2 Exosc8 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism Tnfaip8l1 Inpp5f Mtm1 Pik3r4 Synj1 Ptpn13 Pip4k2c Plekha6 Gdpd5 Pik3c2b Gdpd1 Mtmr7 Mtmr6 Mtmr4 Inpp4a Pik3r5 Rab14 Hadha Gpcpd1 Ptpmt1 Ptdss2 Pik3cg Slc44a2 Pitpnb Cpne1 Pnpla3 Cpne3 Pi4k2b Lpcat4 Pla1a Phospho1 Pgs1 Abhd3 Cpne6 Pik3r1 Plaat3 Pla2g3 Mgll Csnk2b Gpat4 Etnk1 Chpt1 Gpat2 Lpin1 Stard10 Dgat2 Mboat7 Chkb Crls1 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2bu2 H2ax H2bc9 H2bc7 H2bc8 Srpk1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function Rdh12 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN Tbk1 Trex1 Nlrc3 Nlrp4e Prkdc CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing Adarb1 Apobec4 Adar Apobec2 Apobec1 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD Apoa1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis F12 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception Ldb1 Retsat Apoe Clps Lhx2 Slc17a8 Nmt1 Scnn1b Scnn1g Rdh12 Opn1sw Calhm1 Pde6a Pde6b Sptan1 Sdc3 Gpc3 Gpc2 Gpc4 Rdx Pjvk Or5v1 Xirp2 Or52d1 Eps8 Ppef1 Pclo Tas2r39 Kcnn2 Tas2r38 Strc Or51b6 Cib2 Or6c76 Cdh23 Myo7a Or10k2 Or51i2 Otof Or2t44 Tprn Or51i1 Ripor2 Or8d1 Or7c70 Atp2b1 Or2a7 Or10h1b Tas1r1 Tas1r3 Or10h28 Or52w1 Capza1 Or5p6 Tas2r16 Or5m10 Tas2r13 Or4n4 Or4a47 Tas2r137 Tas2r136 Gnb1 Or51f1d Rpe65 Tas2r140 Kcnmb1 Or1i2 Or2t1 Tas2r119 Or10h5 Rdh8 Tas2r4 Tas2r7 Or51e2 Or51m1 Or8i2 Tas2r120 Or5p80 Apoc2 Or4c11 Or14j1 Otop1 Or8h10 Tas2r107 Or2ag1 Rcvrn Apoc3 Or10a4 Or12d17 Or10a5 Tas2r40 Tas2r41 Rdh16f2 Or10a2 Dhrs9 Myh9 Trpm4 Apoa1 Apoa2 Apoa4 Chrna9 Apob ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence Cdk6 Tfdp1 Tnrc6a Cdkn2b Mapk1 Mdm2 E2f2 Cdkn2a Cdkn2c E2f3 Tfdp2 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 Prkar2a Ppp3cb Akap5 Prkacb RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib Cdc37 Erbin DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants Kit DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation Alg8 Alg3 Gfpt1 Slc26a2 Hexb Cspg5 Notch3 Sdc3 Galm Gne Dhdds Gpc3 Gpc2 Gpc4 Adamts1 Muc1 Adamts20 Adamts10 Sema5a Thsd7a Cfp Ctsa Thbs2 Muc4 Adamtsl5 Thsd4 Pgm1 Neu1 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production Nos2 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins Iscu DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot Serpinb8 Plau Plat S100a10 Serpinb6a Serpine2 Plg COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic Dync1i2 Dync1h1 Dctn1 Bicd2 Bicd1 Dctn2 Pafah1b2 Capza1 Dynll1 Dynll2 Actr1a Actr10 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs Tnrc6a DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Gpc3 Gpc2 Gpc4 Sdc3 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism Gadl1 Nat8l Aspa FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex Ercc3 Cops8 Xab2 Cops7a Cops7b Usp7 Polr2k Polr2g Isy1 Gtf2h2 Gtf2h3 Gtf2h5 Rbx1 Ddb1 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Map2k2 Ptpn7 Map2k1 Mapk1 Dusp10 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells Plcg2 Cbl Il34 Ptpn11 Pik3r1 DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle Nmral1 Nags Asl SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 Dph3 Dph5 Dph6 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC Muc1 Muc4 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity Bach1 H13 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants Ctbp1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Fads1 Elovl5 Hsd17b4 Fads2 Elovl1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System Exo1 Itgav Rfc5 Rfc3 Rfc4 Rfc2 Mlst8 Plcg2 Mapkap1 E2f7 E2f8 Orai2 Stim1 Rfc1 Lgmn Treml1 Siglec1 Nectin2 Cd200r1 Siglec12 Klrb1 Crtam Jaml Icam5 Lilra5 Pik3r5 Dctn1 Prkcb Btk Sec31a Icos Brd4 Ctnnbl1 S100a1 Dynll2 Cyba Csnk2b Cybb Sh3kbp1 E2f2 Actr1a Erlin2 Dync1h1 Erlin1 Dctn2 Ctr9 Dynll1 Dync1i2 Cd300a Evl Btrc Was Csk Blnk H2ax Batf H2bu2 Maf Ahcyl1 Mib2 Mad2l2 Rev1 Map3k8 Polr2k Ncoa6 Tead4 H2bc9 H2bc7 H2bc8 Ctla4 Rbbp7 Trib3 Nfkbie Rel Tead3 Ezh2 Ptprj Tead2 H3c7 Sipa1 Rap1gap2 Ptpn22 S100a9 Psmd12 Psmd11 Psma6 Psmd8 Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Exosc9 Exosc8 Erap1 Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Akt1 Mphosph6 Prkacb Rbx1 Itch Fgb Fga Fgg Ctsa Ell Polr2g Xdh Sec13 Taf11 Taf13 Taf12 Gtf2f1 Ssrp1 Taf7 Taf5 Taf2 Cr2 Uba7 Ap2a2 Ap2a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cd3g Myd88 Pik3cg Prkag2 Ap1s3 Pik3r1 Tnrc6a Ube2c Fzr1 Anapc11 Anapc10 Anapc1 Ppp3cb Dad1 Akt3 Akt2 Jak1 Stt3b Kctd7 Hectd1 Hectd3 Rnf220 Pik3r4 Ube2b Mkrn1 Rpn2 Blmh Ube2a Fbxl20 Rnf213 Rpn1 Btbd1 Rnf138 Ube2v1 Fbxw8 Asb16 Ube2l3 Rnf126 Dcaf1 Ripk2 Herc2 Fbxo21 Ptpn11 Ubox5 Ube2r2 Magt1 Rnf6 Uba6 Itk Fbxo7 Cd207 Trim21 Sec22b Klhl25 Sec61a2 Klhl20 Klhl2 Spsb2 Fbxl14 Spsb1 Fbxl16 Trim37 Btla Fbxl19 Lonrf1 Asb7 Tmem258 Rnf25 Tab2 Rchy1 Myb Ube2j1 Tcf7l1 H2-Q10 Ctsf Kif18a Ctsh Kif2c Aff4 Cd84 Tnfsf13b Supt6 Klc2 H2-Oa Capza1 Icosl Sh2d1a Fbxw4 Actr10 Il21 Mllt3 Ppl Racgap1 Apex2 Polh Jun Pdcd1lg2 Map3k14 Rab7 Epas1 Btn1a1 Myh9 Pcna Tlr4 Ly96 Cdc34 Prkag3 Rap1a BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases Otub1 Zranb1 Otud5 Rhoa Nod1 Ripk2 Ripk1 Rigi INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement C1qc Crp C1qa Colec10 C1qb C1rb Cfd Cfb MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction Myl6b Scn8a Kcnk7 Kcnk6 Tmod3 Kcnip3 Cacna1h Atp1a1 Scn11a Ahcyl1 Camk2g Camk2d Camk2b Camk2a Nkx2-5 Atp1b1 Tbx5 Tpm3 Atp1b3 Hipk1 Orai2 Stim1 Nppc Kcnk9 Cacna1i Atp2b2 Tnnt3 Atp2b1 Tnnt2 Slc8a1 Ttn Slc8a2 Tmod1 Kcnk4 Kcnq1 Kcnk2 Kcne5 Tnni3 Kcnk10 Myl4 Myl7 Mybpc3 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs Rit2 Cdk5 Id4 Gab1 Irs1 Mapk14 Frs2 Ap2a2 Ap2a1 Pik3r1 Egr1 Mef2c Bdnf Ppp2r5d Rhoa Trib1 Rap1a Irs2 Map2k2 Crk Map2k1 Tph1 Mapk1 Ptpn11 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery Rps25 Rps26 Rps27 Hnrnpa1 Rps21 Rps11 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events Camk4 Camk2a Camkk2 Prkar2a Pde1a Prkar1a Mapk1 Prkacb Camk2g Camk2d Camk2b AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors Htr6 Taar5 Adra2a Htr1a Drd4 Drd5 Chrm5 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate Pou5f1 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors Psmb1 Psmc2 Nup133 Psma7 Psip1 Ap1s3 Ap2a2 Ap2a1 Npm1 Nup205 Nup107 H2-Q10 Sec13 Btrc Atp6v1h Psmd12 Rcc1 Nup85 Rbx1 Psmd11 Psma6 Psmd8 Nup88 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis Polr2k Polr2g Bcdin3d Xpo5 Dgcr8 Dicer1 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins Pdcd6ip Map2k2 Map2k1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response Casp3 Mapk1 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema F12 Klkb1 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function Exo1 Bard1 Rbbp8 Palb2 Wrn POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription Klf9 Strap Foxp2 Foxa2 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR Htr6 Taar5 Htr1a Ramp2 Sct Pde7b Apln Rgs8 Wnt10b Galr1 Kel Camk2g Rxfp1 Camk2d Pnoc Camk2b Grk6 Tas2r131 Camk2a Gpr83 Tas2r135 Opn3 Gper1 Gpsm3 Akt1 Gpsm1 Npbwr1 Ramp1 Prkar2a Ppp1r1b Prkar1a Ptger2 Ptger3 Prkacb Prokr1 Grm8 Rgs2 Gpr20 Dgkb Gipr Lpar4 Ptgir Lpar3 Gpr35 Lpar2 Wnt8a Lpar1 Rgs22 Prkch Glp2r F2 Dagla S1pr3 Xcl1 Wnt7a Grp S1pr2 Ffar3 Gpr37l1 Bdkrb2 Ackr1 Bdkrb1 Cort Rgs17 Ramp3 Chrm5 Gnai2 P2ry13 P2ry2 Gpr55 P2ry1 Tac3 Gprc6a Opn4 Nmb Dgkk Plcb4 Lpar5 Cck Ppan Prok1 Dgkz Nms Ltb4r2 Gast F2rl2 Gip Adra2a Pik3r5 Ppp2r5d Avpr1b Gnaz Cysltr1 Prkcb Btk Opn1sw Pik3cg Pik3r1 Rasgrf2 Mgll Arrb1 Wnt5a Ppp3cb Arhgef15 Egfr Arhgef17 Gnat2 Fzd4 Arhgef11 Fzd7 Fzd6 Akt3 Akt2 Ffar1 Ccl22 Ccl20 Ccl2 Ackr4 Cxcl5 Fshr Tshr Prex1 Tas2r39 Tas2r38 Pde3b Drd4 Drd5 Tas1r1 Tas1r3 Psap Gna14 Tas2r16 Tas2r13 Gng3 Gnb2 Tas2r137 Tas2r136 Gnb1 Pde10a Tas2r140 Gnb4 Pde11a Ahcyl1 Pde1a Tas2r119 Tas2r4 Tas2r7 Tas2r120 Camkk2 C3ar1 Rhoa Tas2r107 Tas2r40 Tas2r41 Gabbr2 Camk4 Trpc6 Cdk5 Npy Mapk1 Mchr1 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress Eif2s3x Eif2s2 Phb2 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation Mapk1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling Arpc4 Rhoa Actr2 Cfl1 Actr3 Ptk2 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis H2bu2 Ajuba Ccnc Med16 Med17 Elovl5 Ncoa6 Cidec H2bc9 H2bc7 H2bc8 Fabp4 Med31 Ppargc1b Phlda1 Cdk8 Cdk5 H3c7 Mgll H2ax Med23 Lpin1 Med24 Plin2 Dgat2 Scd1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation Ptgds Zfpm2 Amh BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation ATP6 Micos10 Immt Hspa9 Mtx2 Dnajc11 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 Ube2v1 Birc3 Birc2 Ripk1 Tlr4 Ly96 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs Zfp473 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA Psip1 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry Gpc3 Gpc2 Uba6 Gpc4 Mapre3 Uba7 Ap2a2 Ap2a1 Pik3r1 Ly6e Cd300a Sdc3 Tyro3 Cldn1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell Adam17 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B Ube2c Anapc11 Anapc10 Anapc1 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) Tead4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation Thrap3 Med31 Pck1 Ccnc Cdk8 Med16 Med17 Wnt10b Klf5 Slc2a4 Med8 Ncoa6 Med23 Med24 Tnf Fabp4 Med28 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation Psen2 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism Mgll Ppp1cc Abhd5 Fabp3 Prkacb Fabp4 Fabp5 Fabp6 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) Cyba Cybb Itgav SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response Casp3 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade Pde6a Pde6b Gnb1 Nmt1 Rcvrn Ppef1 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling Bdnf MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Exo1 Bard1 Rbbp8 Palb2 Rtel1 Wrn HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection Psmb1 Chmp6 Psmc2 Pdcd6ip Ssrp1 Nup133 Xrcc4 Psma7 Taf7 Nmt1 Taf5 Taf2 Ap2a2 Ap2a1 Polr2k Npm1 Gtf2h2 Gtf2h3 Btrc Atp6v1h Gtf2h5 Rbx1 Ercc3 Psip1 Ap1s3 Ell Polr2g Ubap1 Nup205 Nup107 H2-Q10 Tsg101 Sec13 Taf11 Mvb12a Taf13 Taf12 Psmd12 Rcc1 Gtf2f1 Psmd11 Nup85 Psma6 Chmp3 Psmd8 Nup88 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System Itgav Pdxk Plcg2 Gns Rfc1 Lgmn Eif3l Eif3e Gpi Eif3b Eif3c Asah1 Ecsit Man2b1 Il33 Pik3r5 Egr1 Dctn1 Bin2 Pygb Sec31a Icos Agl Brd4 Pygl Ctnnbl1 S100a1 Kpna4 Ip6k2 Sh3kbp1 Unc93b1 E2f2 Il1r1 Erlin2 Erlin1 Acly Ctr9 Hpse Cd300a C1qa Cgas Oas2 Blnk Eif4g3 Gbp2 Pgm2 Mgst1 Serpinb1a Pgm1 Psap Taldo1 Ahcyl1 Mad2l2 Rev1 Hsp90b1 Rab14 Prkdc Trib3 Rab27a Neu1 Erap1 Polr3a Polr3d Polr3f Polr3k Mphosph6 Maoa Gaa Dera Ctsa Xdh Fabp5 C1qb C1rb Cr2 Cpn1 C7 C9 Cd46 Cpb2 C1qc Pkm Ampd3 Anpep Pik3cg Ebi3 Prkag2 Crlf1 Idh1 Cnpy3 Hspa9 Ca1 Fancb Ccl22 Ccl20 Ilf3 Ptpn13 P2rx7 Pycard Aim2 Sugt1 Itk Casp1 Cd207 Sec22b Sec61a2 Hgf Btla Myb Tcf7l1 Ctsf Kif18a Ctsh Kif2c Aff4 Rbsn Cd84 Tnfsf13b Supt6 Klc2 H2-Oa Capza1 Icosl Sh2d1a Actr10 Il21 Mllt3 Apex2 Racgap1 Polh Atg5 Sh2b3 Eif2s3x Eif2s2 Pdcd1lg2 Map3k14 Rab7 Tnfsf15 Tnfrsf9 Nos2 Lta Atp6v1h Eda2r Il12rb1 Tnfrsf13b Il12rb2 Cfl1 Il12b Pdcd4 Il12a Snrpa1 Sod2 Hnrnpa2b1 Btn1a1 Myh9 Pcna Lamtor2 Prkag3 Pin1 Exo1 Fancc Rfc5 Rfc3 Rfc4 Rfc2 Mlst8 Mt2 Npm1 Casp2 Pml Pecam1 Mapkap1 E2f7 E2f8 Orai2 Stim1 Il21r Treml1 Siglec1 Nectin2 Cd200r1 Siglec12 Klrb1 Crtam Jaml Icam5 Lilra5 Dsp Ckap4 Sirpb1b Nckap1l Wipf3 Tasl Actr2 Ly86 Actr3 Prkcb Itgam Btk Irf5 Stom Flna Slc44a2 Cpne1 Cpne3 Abl2 Nf2 Dynll2 Ptk2 Csnk2b Cyba Cybb Arpc4 Rhof Actr1a Rac2 Dync1h1 Iqgap2 Dctn2 Sptan1 Dynll1 Dync1i2 C1qbp Evl Btrc Ctsg Was Klkb1 Adam17 Trex1 Csk Nlrc3 Nlrp4e Adar Wasf3 Casp3 Wasf2 Mmp9 Mmp1a Abi2 H2ax Il13 Tnf Batf H2bu2 Maf Tnfrsf1a Birc3 Mib2 Birc2 Map3k8 Mef2c Polr2k Ncoa6 Tead4 H2bc9 H2bc7 H2bc8 Ctla4 Rbbp7 Plau Serpinb6a Pafah1b2 Ptpn7 Il34 Nfkbie Rel Tead3 Ezh2 Tead2 Ptprj H3c7 Sipa1 Bpifb2 Rap1gap2 Bpifa1 Lifr Ptpn22 Pdzd11 Rnase2b Prtn3 Otud5 Pglyrp2 Crp Art1 Colec10 Defb23 Reg3g S100a9 Atox1 Chga Csf2 Psmd12 Il2 Psmd11 Psma6 Psmd8 Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Exosc9 Exosc8 Camk2g Camk2d Mapk14 Camk2b Exosc4 Camk2a Dis3 Exosc6 Exosc1 Exosc2 Tnfsf13 Akt1 Prkacb Rbx1 Itch Fgb Fga F12 Fgg F2 Muc1 Cfp Cfd Cfb Muc4 Slco4c1 Ell Gbp7 Polr2g Cystm1 Pa2g4 Nup205 Snap29 Nup107 Ifnlr1 Il18r1 Ifit3b Sec13 Clec4b2 Taf11 Enpp4 Card9 Taf13 Trim8 Atp8a1 Taf12 Crispld2 Atp6v0a4 Crlf2 Gtf2f1 Nup85 Plekho2 Rab37 Nup88 Hp Ilf2 Ptprb Atp11b Lamp1 Ssrp1 Lamp2 Nup133 Arl8a Rab3d Taf7 Il2rb Siglec15 Taf5 Ptpn2 Taf2 Hexb Il1r2 Slpi Dhx58 Ifi35 Tcirg1 Uba7 Rigi Prcp Il20ra Ap2a2 Cant1 Ap2a1 Txk Ppp2r5e Dhx36 Vat1 Ppp2r5d Tollip Ppp2r5c Prg3 Ppp2r5b Rap2c Ppp2r5a Il15 Atp6v1a Il19 Atp6v0d2 Osmr Orm3 Atp6v1f Rnasel Abca13 Il10rb Cd3g Cab39 Irag2 Nkiras1 Cd63 Nkiras2 Il25 Peli1 Rag2 Myd88 Rag1 Dpp7 Usp14 Isg20 Il13ra1 Clec4e Trim62 Irf6 Il7r Cpped1 Irf9 Ap1s3 Trim38 Irs1 Ms4a2 Rab5c Trim31 Pik3r1 Tec Fth1 Ptpn20 Tnrc6a Csf2ra Ube2c Irs2 Fzr1 Anapc11 Prlr Anapc10 Ppp3cb Anapc1 Dad1 Rps11 Tbk1 Akt3 Akt2 Jak1 Tyk2 Stt3b Ano6 Kctd7 Hectd1 Ifna16 Tlr7 Hectd3 Rnf220 Pik3r4 Ube2b Mkrn1 Rpn2 Blmh Ube2a Fbxl20 Rpn1 Rnf213 Btbd1 Ube2v1 Rnf138 Nod1 Fbxw8 Asb16 Ube2l3 Golga7 Rnf126 Dcaf1 Ripk2 Herc2 Fbxo21 Ptpn11 Ubox5 Ube2r2 Magt1 Rnf6 Uba6 Fbxo7 Rps25 Rps26 Trim21 Klhl25 Klhl20 Rps27 Klhl2 Spsb2 Fbxl14 Spsb1 Irak1 Il17f Fbxl16 Rps21 Trim37 Il17a Fbxl19 Lonrf1 Asb7 Rnf25 Tmem258 Rchy1 Tab2 Ube2j1 H2-Q10 Gsdme Myo10 Myo5a Fbxw4 Pkp1 Ppl Gsdmd Sphk1 Jun Flt3 Frk Dock1 Cbl C3ar1 Rhoa Epas1 Crk Eif4e Lrrc7 Traf2 Ripk1 Tlr4 Ly96 Cdc34 Rap1a Map2k1 Mapk1 Apob SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Cyp7a1 Hsd17b4 Abcd3 Amacr Slc27a5 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint Psmb1 Psmc2 Psma7 Btrc Psmd12 Psmd11 Rbx1 Mapk14 Psma6 Psmd8 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer Jag1 Adam17 Hdac5 Ccnc Cdk8 Mib2 Mamld1 Hes5 Psen2 Mib1 Jag2 Rbx1 Hdac1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes Bmp1 Tll1 Col4a4 Col15a1 Serpinh1 Col6a3 Col17a1 Col18a1 Col4a5 Col12a1 Ppib INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER Parp2 Ercc3 Rad23a Rad23b Rpa2 Gtf2h2 Rpa3 Gtf2h3 Gtf2h5 Pias3 Rbx1 Xpc Ddb1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway Tab2 Tnfrsf1a Sharpin Birc3 Birc2 Traf2 Tnf Ripk1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity Camk2a Myo6 Mdm2 Akap5 Cacng3 Prkcb Camk2g Camk2d Camk2b Ap2a1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Bckdhb GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation Aldh5a1 Cplx1 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes Pitpnb INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function Bard1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Ltc4s REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate Rpa2 Pold4 Pola2 Rpa3 Pcna DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling Psmb1 Pycard Psmc2 Psma7 Ahcyl1 Cdc34 Plcg2 Tab2 Map3k14 Btrc Ube2v1 Card9 Psmd12 Ppp3cb Psmd11 Psma6 Psmd8 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing Abhd17c Abhd17b Rce1 Zdhhc9 Golga7 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage Ascc2 Ascc1 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle Rac2 Racgap1 Emd Git1 Lemd3 Diaph3 Arhgap17 Dock1 Cdc42ep1 Rab7 Nckap1l Erbin Baiap2l1 Bcr Ophn1 Slitrk5 Nhs Mcam Prex1 Wasf2 Pik3r1 Abi2 Lbr Cyba Cybb Arhgap42 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 Bdnf Ins2 Tnrc6a Arnt2 Arnt Kcnip3 Cdk5 Mapk1 Mdm2 Nr3c1 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules Bpnt1 Sult4a1 Podxl2 Sult1e1 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions Tufm Tbk1 Akt3 Nup133 Akt2 Jak1 Tyk2 Vps33a Vps33b Rigi Ifna16 Tlr7 Pik3r4 Vps11 Akt1 Ube2v1 Nod1 Pals1 Vps16 Ripk2 Sftpd Ptpn11 Rps25 Rps26 Rps27 Irak1 Il17f Rps21 Il17a Gemin2 Tab2 Nup205 Ddx20 Nup107 H2-Q10 Sec13 Nup85 Rps11 Nup88 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation Gars1 Aars2 Wars2 Pars2 Yars2 Ears2 Ppa2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maoa DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation Lipt1 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2a DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis Pik3r4 Mapkap1 Taok1 Mlst8 Ripk1 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis Fga F10 F11 Fgg F2 F9 Ano6 Fgb TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Tfdp1 Mybl2 Hdac1 Tfdp2 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors Htr6 Htr1a SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer Jag1 Adam17 Mib1 Mib2 Jag2 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism Alg8 Lmbrd1 Alg3 Hibch Slc26a2 Btd Pcx Nmral1 Sdc3 Galm G6pc1 Auh Dhdds Gns Sftpd Maoa Gpc3 Gpc2 Gaa Gpc4 Adamts1 Muc1 Adamts20 Adamts10 Tcn2 Sema5a Thsd7a Ctsa Cfp Thbs2 Muc4 Adamtsl5 Thsd4 Ada Pgm1 Bckdhb Ahcy Cyp7b1 Mmab Taldo1 Gfpt1 Hexb Cspg5 Nags Notch3 Bckdk Ggt1 Gne Cyp11b1 Cyp11b2 Ppm1k Nhlrc1 Idh1 Csf2ra Sftpa1 Oplah Cd320 Slc37a4 Mtr Ppp1r3c Neu1 Asl SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS Mapk14 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids Acsm5 Glyatl3 Glyat Acsm4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins Rtn4rl2 Xpnpep2 Msln Gpld1 Pigv Tectb Tecta Otoa Rtn4rl1 Pigk Ly6g6c Pigg Izumo1r Prss41 Ly6g6d Ly6d Ly6e Folr2 Pyurf Pigs Alppl2 Nrn1 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS Maoa SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters Slc6a2 Slc6a5 Slc17a8 Slc25a18 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors Lpar4 Ppan P2ry13 P2ry2 P2ry1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 Ripk1 Rigi RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation Maf Satb2 Mapk1 Ucma Ar SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane Rpl4 Serp1 Rps25 Rpl39 Rps26 Rpl7 Rps27 Sec61a2 Rps21 Srp9 Srp68 Rpl22 Rpl18 Rps11 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2bu2 Chmp6 Nup133 Dync1h1 Dynll1 Dync1i2 Pml H2bc9 H2bc7 H2bc8 Rbbp7 Dynll2 Ezh2 H3c7 Ubap1 Chmp1a Nup205 Nup107 Tsg101 Sec13 Vps25 Mvb12a Nup85 Egfr Chmp3 Nup88 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres Fbln5 Itgav Tgfb2 Mfap5 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation Rffl Akt3 Ppp2r5c Akt2 Mapkap1 Akt1 Phf20 Mdm2 Mlst8 Usp7 Ccna1 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism Xdh Gda MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades Psmb1 Psmc2 Sptbn4 Sptb Psma7 Jak1 Tyk2 Sptan1 Camk2g Camk2d Camk2b Camk2a Mapk4 Etv4 Rasgef1a Zdhhc9 Ranbp9 Apbb1ip Prkacb Golga7 Tek Rbx1 Fgb Ptpn11 Fga Csk Fgg Rasa4 Nf1 Dab2ip Hgf Spred1 Rasal3 Spred3 Areg Spred2 Dusp10 Fgf7 Fgf22 Map3k11 Ppp1cc Il2rb Klb Jun Fgf15 Kit Flt3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Phb1 Mras Rag2 Rag1 Lrrc7 Gdnf Ptpn7 Lamtor2 Irs1 Frs2 Pik3r1 Ptk2 Rasgrf2 Tnrc6a Abhd17c Abhd17b Arrb1 Csf2ra Rce1 Irs2 Rap1a Map2k2 Csf2 Map2k1 Mapk1 Psmd12 Il2 Psmd11 Egfr Psma6 Psmd8 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 Ppp2r5e Ctla4 Ppp2r5d Akt3 Ppp2r5c Akt2 Ppp2r5b Ppp2r5a Akt1 Ptpn11 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation Pola2 Stn1 Terf2 Terf2ip O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation St6galnac3 St6gal1 B3gnt2 B3gnt6 Galnt10 Galnt17 Galnt15 Pomk Galnt16 Galnt14 Gcnt1 Pofut2 Fkrp Slc35a4 Slc35a1 Crppa Adamts1 Large2 St3gal4 Fktn Muc1 Adamts20 Adamts10 St3gal1 Sema5a Thsd7a Cfp Thbs2 Muc4 Adamtsl5 Thsd4 B4galt6 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Pou5f1 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels Gabbr2 Gng3 Gnb2 Gnb1 Gnb4 Kcnj3 Kcnj10 Kcnj5 Kcnj15 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome Psmb1 Psmc2 Psma7 Btrc Psmd12 Prkacb Psmd11 Rbx1 Psma6 Itch Psmd8 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition Rps25 Rps26 Rps27 Rps21 Eif3l Eif3e Eif2s3x Eif2s2 Eif3b Eif3c Eif4b Eif4e Rps11 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA Pabpc1 Cnot7 Cnot6 Cnot9 Eif4b Eif4e DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism Chp1 Hmmr Slc9a1 Hexb Cemip Hyal3 Has3 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation Exo1 Tcf3 Dync1h1 Rfc5 Rfc3 Dctn2 Rfc4 Rfc2 Exosc9 Dynll1 Exosc8 Ctr9 Dync1i2 Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Mphosph6 E2f7 E2f8 Rfc1 Ctsa Ell Polr2g Myb Ctsf Kif18a Ctsh Taf11 Aff4 Kif2c Taf13 Cd84 Taf12 Tnfsf13b Supt6 Gtf2f1 H2-Oa Klc2 Capza1 Icosl Batf Sh2d1a Actr10 Il21 Maf Mllt3 Racgap1 Ssrp1 Apex2 Polh Taf7 Taf5 Taf2 Cr2 Mad2l2 Rev1 Polr2k Ncoa6 Rab7 Dctn1 Icos Myh9 Ctnnbl1 Pcna Dynll2 E2f2 Actr1a BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA Hsd17b4 Amacr Crat NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions Ank1 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade Psmb1 Psmc2 Sptbn4 Sptb Psma7 Jak1 Sptan1 Camk2g Camk2d Camk2b Camk2a Rasgef1a Zdhhc9 Ranbp9 Apbb1ip Golga7 Tek Rbx1 Fgb Fga Csk Fgg Rasa4 Nf1 Dab2ip Hgf Spred1 Rasal3 Spred3 Areg Spred2 Dusp10 Fgf7 Fgf22 Map3k11 Ppp1cc Il2rb Klb Fgf15 Kit Flt3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Phb1 Mras Lrrc7 Gdnf Ptpn7 Lamtor2 Irs1 Frs2 Pik3r1 Ptk2 Rasgrf2 Abhd17c Abhd17b Arrb1 Csf2ra Rce1 Irs2 Rap1a Map2k2 Csf2 Map2k1 Mapk1 Psmd12 Il2 Psmd11 Egfr Psma6 Psmd8 METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance Tomt Comt Maoa GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization Rab1b Golga2 Gorasp1 Mapk1 Ccnb2 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling Psmb1 Psmc2 Tbk1 Psma7 Gsdmd Ptpn2 Il1r2 Il33 Map3k8 Tollip Ptpn13 Btrc Ube2v1 Nod1 Ctsg Ripk2 Rbx1 Nkiras1 Ptpn11 Nkiras2 Peli1 Myd88 Usp14 Casp1 Ptpn7 Irak1 Traf2 Ptpn20 Tab2 Il18r1 Il13 Map2k1 Psmd12 Il1r1 Psmd11 Psma6 Psmd8 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors Pias3 Mdm2 Mitf ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC Cd320 Tcn2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase Tuba1a Nuf2 Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Ccnb2 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Cenpa Wapl Stag2 Smc3 Nsl1 B9d2 Rps27 Taok1 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Kif2c Ppp1cc Nup85 Nup133 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Nek9 Nek6 Ska1 Ahctf1 Dynll2 Csnk2b Tubgcp5 Tubgcp4 Nudc Nedd1 Actr1a NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis Gpc3 Gpc2 Gpc4 Sdc3 Cspg5 Fam20b Xylt2 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) Psmb1 Pycard Psmc2 Psma7 Clec4e Ahcyl1 Muc1 Muc4 Cdc34 Plcg2 Tab2 Map3k14 Clec4b2 Btrc Ube2v1 Card9 Psmd12 Ppp3cb Prkacb Psmd11 Psma6 Psmd8 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Eif3l Eif3e Eif2s3x Eif2s2 Eif3b Eif3c Rpl22 Rpl18 Eif4b Eif4e Eif5b Rps11 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA Rpl4 Rps25 Rpl39 Rps26 Rpl22 Rpl18 Rpl7 Rps27 Rps21 Rps11 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi St3gal4 St3gal6 Notch3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling Lifr UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes Lmbrd1 Prss2 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH Ggt1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Hadha Mecr GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors F10 F2 F9 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts Slc10a2 Slco1b2 Stard5 Slc27a5 Fabp6 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR Klb Spred1 Fgf15 Gab1 Spred2 Frs2 Pik3r1 Polr2k Fgf7 Polr2g Fgf22 Cbl Hnrnpa1 Mapk1 Gtf2f1 Ptpn11 Fgfrl1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases Ascc2 Ascc1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors Tnfsf15 Tnfsf13 Tnfrsf9 Tnfrsf1a Lta Eda2r Tnfrsf13b Tnfsf13b SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Plxna1 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions Erlin2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB Camk4 Camk2a Camkk2 Camk2g Camk2d Camk2b MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition Psmb1 Cdk6 Psmc2 Akt3 Akt2 Psma7 Mybl2 Gmnn Orc1 Orc2 Cdkn2c E2f3 Tfdp2 Tfdp1 Rpa2 Ptk6 Tyms Akt1 Rpa3 E2f6 Pcna Cdkn2b Mcm8 Cdc45 Pola2 Ccne1 Psmd12 Cdkn2a Ppp2r2a E2f2 Psmd11 Hdac1 Psma6 Ccna1 Psmd8 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF Fga Csk Fgg Camk2g Camk2d Camk2b Camk2a Arrb1 Map3k11 Apbb1ip Rap1a Phb1 Map2k2 Map2k1 Mapk1 Fgb FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct Ctnnb1 Hoxb4 Hoxa6 Lhx1 Pax8 Id4 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing Polr2k Polr2g Hnrnpa1 Gtf2f1 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses C1qa Cgas Ctr9 Apoa1 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) Rpl4 Smg6 Smg5 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Etf1 Upf3a Gspt1 Pabpc1 Rpl22 Rpl18 Ppp2r2a Rps11 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors Coq6 Coq8a Pdss2 Akt1 Spr Idh1 Gch1 Aco1 Coq4 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling Cbl Mapk1 Frs2 Ptpn11 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping Polr2k Ercc3 Polr2g Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Sod2 Golga2 Cdk5 Jun SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane Plekha6 Pik3cg Pi4k2b Pik3c2b Mtm1 Mtmr6 Pik3r5 Pik3r1 Synj1 Rab14 Inpp4a Ptpn13 Pip4k2c DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism Lmbrd1 Btd Cd320 Pcx Tcn2 Mtr Mmab INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection Rpl4 Nup133 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Kpna4 Polr2k Polr2g Nup205 Nup107 Rpl22 Rpl18 Sec13 Pabpn1 Gtf2f1 Nup85 Nup88 Rps11 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE Unc93b1 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 Mef2c Ncoa6 Crtc3 Rai1 Nrip1 Crtc1 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints H2bu2 Psmb1 Psmc2 Exo1 Psma7 Rfc5 Rfc3 Orc1 Rfc4 Orc2 Rfc2 Wrn Clspn Ccnb2 Rpa2 Rbbp8 Rpa3 H2bc9 H2bc7 H2bc8 Herc2 Pkmyt1 Rad9a Bard1 H2ax Mcm8 Cdc45 Psmd12 Psmd11 Psma6 Ccna1 Psmd8 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase Tuba1a Nuf2 Psmb1 Cdk5rap2 Psmc2 Cep250 Emd Sdccag8 Dync1h1 Rab1b Psma7 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Ccnb2 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Cnep1r1 Haus5 Csnk1d Cenpa Wapl Stag2 Smc3 Nsl1 Ncapd3 Mau2 B9d2 Rps27 Taok1 Cenpm Lbr Nup205 Cenpi Nup107 H2ax Golga2 Sec13 Cenpf Kif18a Kif2c Ppp1cc Rcc1 Tubb2a Nup85 Chmp3 Nup88 Tubal3 H2bu2 Chmp6 Nup133 Lemd3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a H2bc9 H2bc7 H2bc8 Prkcb Nek9 Nek6 Ska1 Ahctf1 Dynll2 H3c7 Csnk2b Tubgcp5 Gorasp1 Ube2c Tubgcp4 Lpin1 Nudc Anapc11 Anapc10 Mapk1 Psmd12 Ppp2r2a Anapc1 Psmd11 Nedd1 Psma6 Actr1a Psmd8 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels Kcns3 Kcnb1 Kcnab1 Kcns2 Kcnh6 Kcnc1 Kcng2 Kcnab3 Kcnq1 Kcng1 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination H2bu2 Rpa2 Rbbp8 H2ax Mlh3 Rpa3 H2bc9 H2bc7 H2bc8 H3c7 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose Nudt14 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function Mras Ppp1cc MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins Csnk2b Ppp1cc INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption Slc5a1 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) Sv2a ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events Camk4 Lin7c Grin3b Lrrc7 Git1 Prkag2 Nrgn Camk2g Camk2d Camk2b Rasgrf2 Camk2a Prkag3 Camkk2 Prkar2a Prkar1a Mapk1 Prkacb GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sod2 Hnrnpa2b1 Taldo1 Cfl1 Capza1 Pdcd4 Hspa9 Ca1 Snrpa1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression H2-Q10 Ap1s3 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells Chrna9 Kcnmb1 Kcnn2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport Hscb Uqcrc2 Sdhc Sdhb Ndufaf2 Ndufaf1 Bcs1l Slc25a18 Ndufa3 Ndufa7 Coa3 Sco1 Ndufa12 Ndufb2 Higd1c Ndufb6 Cox20 Ndufb8 Mdh1 Timm21 Mdh2 Uqcrfs1 Lyrm4 Lyrm2 Higd2a Tmem186 Hspa9 Ndufs2 Cox16 Ndufs8 Uqcc6 Cox6a1 mt-Cytb Cox6a2 mt-Nd4 mt-Nd5 mt-Nd6 Rab5if Trap1 Ecsit HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) H2bu2 Exo1 Polh Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Wrn Clspn Rpa2 Rbbp8 Rpa3 H2bc9 H2bc7 H2bc8 Herc2 Rfc1 Pold4 Pcna Ppp4c Rad9a Bard1 Eme1 Mus81 Palb2 H2ax Ccna1 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation H2bu2 Rbbp7 Hoxb4 Ajuba Pcgf2 Hoxa2 Jun Hoxb3 Ezh2 Hoxa3 H3c7 Hoxb1 Hoxb2 Polr2k Polr2g Ncoa6 H2ax Cnot6 Cnot9 H2bc9 H2bc7 H2bc8 Yy1 Rara MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling Alk Mdk SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions Fga Csk Fgg Agtrap Camk2g Camk2d Clcn6 Camk2b Ap3b1 Camk2a Arrb1 Apbb1ip Zc3hav1 Rap1a Map2k2 Map2k1 Mapk1 Fgb SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants Fzd6 Fzd4 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Rasgrf2 Camk2a Lrrc7 Mapk1 Camk2g Camk2d Camk2b NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways P2rx7 Pycard Aim2 Sugt1 Casp1 Birc3 Irak1 Birc2 Mapk14 Casp2 Tab2 Ube2v1 Nod1 Card9 Ripk2 Itch ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs Nkiras2 Tbk1 Myd88 Nlrp4e Ripk1 Nkiras1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis Tnrc6a Bcl2a1d Dicer1 Hdac1 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants Flt3 Ptpn11 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines Setd7 Rbbp7 Setd1b Aebp2 Kmt5b Suv39h2 Ezh2 H3c7 Setd3 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis Ap1g2 Arrb1 M6pr Bloc1s1 Dnajc6 Ap1s3 Gns RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine Glyatl3 Glyat CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway Fzd6 Pde6a Gng3 Pde6b Gnb2 Ctnnb1 Gnb1 Gnb4 Tnrc6a Camk2a Tcf7l1 Wnt5a Ppp3cb Gnat2 Fzd4 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation Psmb1 Psmc2 Psma7 Blnk Ahcyl1 Nfkbie Rel Pik3r1 Plcg2 Sh3kbp1 Btrc Orai2 Psmd12 Ppp3cb Stim1 Psmd11 Prkcb Psma6 Btk Psmd8 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM Polr2k Polr2g Gtf2f1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Pfkfb2 Pfkfb1 Ppp2r5d Prkacb Pfkfb4 Pfkfb3 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity Mapk1 Hdac1 Usp9x Smad4 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels Kcnk9 Kcnk7 Kcnk6 Kcnk4 Kcnk2 Kcnk10 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation Jak1 Tyk2 Map2k2 Mapk1 Ptpn11 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions Cldn2 Pals1 Cldn23 Cldn1 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases Rac2 Pik3r4 Cyba Noxa1 Cybb Nox3 S100a9 Mapk1 Pin1 Prkcb Mapk14 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability Akt3 Trib3 Ctnnb1 Akt2 Mapkap1 Akt1 Mlst8 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Alg8 Slc35a1 Alg3 Nagk Amdhd2 Gfpt1 St3gal4 Renbp St6galnac3 St3gal6 St3gal1 Nudt14 St6gal1 Ctsa St6galnac5 Gmppa Dolpp1 Fcsk Gne Neu3 Dhdds Neu1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism Bckdk Hsd17b10 Glyat Hibch Bckdhb Auh Ppm1k Crat CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants Jag1 Adam17 Hdac5 Ccnc Cdk8 Mib2 Mamld1 Hes5 Psen2 Mib1 Jag2 Rbx1 Hdac1 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase Fkbp4 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations Pomk DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) Hdac5 Maf Men1 Rbbp7 Klf13 Jun Mamld1 Gatad2a Cbx4 Il13 Satb1 Bmi1 Phc3 Hdac1 Batf Yy1 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination Mrps16 Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mrpl47 ATP6 Mrpl49 Mrps23 Mrps28 Mrpl52 Mrpl33 Mtrf1l mt-Cytb mt-Nd4l mt-Nd4 Mrpl11 mt-Nd5 Mrpl34 mt-Nd6 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia Tfdp1 Tnrc6a Myb Gmnn Gmnc Mcidas Ccno DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes Pcbp4 Smad4 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE Etnk1 Lpin1 Chkb Phospho1 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic Snap29 Cyth4 Rab36 Cog2 Cog6 Bet1l Cog8 Man1a Cog1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs Casp3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion Wapl Stag2 Smc3 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling Fgf7 Fgf22 Frs2 Ptpn11 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm Dhx38 Thoc1 Thoc3 Nup133 U2af1l4 Thoc6 Nup205 Nup107 Sec13 Eif4e Nup85 Ddx39b Nup88 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency Eif2s3x Trib3 Eif2s2 Chac1 Ppp1r15a VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs Nup205 Nup133 Nup107 Sec13 Psip1 Nup85 Nup88 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants Kit PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation Camk2a Scn8a Scn11a Camk2g Camk2d Camk2b NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia F10 F9 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape H2bu2 Ercc3 Ubtf Taf1d H3c7 Polr2k H2ax Gtf2h2 Gtf2h3 Gtf2h5 H2bc9 H2bc7 Rrn3 H2bc8 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects Cdk6 Cdkn2a IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex Peli1 Ube2v1 Irak1 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers H2bu2 Pck1 Ssrp1 Tcf3 Myog Ctnnb1 Myod1 Axin2 Ctr9 Pwwp2a Phf5a Zmynd8 Tcf19 Ikzf1 Pwwp2b Adnp G6pc1 H2bc9 H2bc7 H2bc8 Snrpa1 Fam124b Rbbp7 Chd6 Igf2 Sf3b6 Snrpn Gatad2a Cherp H3c7 H2ax Puf60 Nqo1 Hdac1 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma Apoa1 Hp HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC Gpcpd1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Rbx1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Pabpc1 Eif3l Eif2b4 Eif3e Eif2s3x Eif4ebp1 Eif2s2 Eif2b1 Eif3b Eif3c Rpl22 Rpl18 Eif4b Eif4e Eif5b Rps11 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification Psmb1 Psmc2 Magt1 Erlin2 Psma7 Erlin1 Jak1 Prkag2 Mib2 Stt3b Tmem258 Csnk2b Rpn2 Pdcd1lg2 Prkag3 Rpn1 Btrc Psmd12 Rbx1 Psmd11 Psma6 Dad1 Psmd8 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration Rhoa ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K Bdnf Gab1 Pik3r1 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins Scn8a Sptbn4 Sptb Scn11a Ank1 Sptan1 L1cam RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle Srgap2 Git1 Txnl1 Stam2 Myo6 Sptan1 Usp9x Pik3r1 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis Atp1a1 Ahcyl1 Camk2g Camk2d Camk2b Camk2a Atp1b1 Atp2b2 Atp1b3 Atp2b1 Slc8a1 Slc8a2 Orai2 Stim1 Tnni3 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling Tbk1 Otud5 Atg5 Pin1 Uba7 Rigi Itch FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation Fga Fgg F2 Serpine2 Fgb PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism Mcee CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis Chsy3 Cspg5 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation Hgf PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 Fzr1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery Ell Polr2k Polr2g Ssrp1 Gtf2f1 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects Cdk6 Tfdp1 Ccne1 E2f2 E2f3 Tfdp2 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade Rac2 Plcg2 Pik3cg Rhoa Pdpn Mpig6b Ptpn11 Pik3r5 Pik3r1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r13 Gabbr2 Tas2r137 Tas2r136 Tas2r140 Tas2r119 Tas2r4 Tas2r39 Tas2r7 Tas2r38 Gprc6a Tas2r131 Tas2r120 Tas2r135 Tas2r107 Tas1r1 Tas1r3 Grm8 Tas2r16 Tas2r40 Tas2r41 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation Gjb4 Gja8 Myo6 Gjc2 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex Psmb1 H2bu2 Psmc2 Psma7 Gmnn Orc1 Orc2 H3c7 H2ax Mcm8 Ube2c Fzr1 Anapc11 H2bc9 Anapc10 H2bc7 Psmd12 H2bc8 Anapc1 Psmd11 Psma6 Psmd8 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Tfdp1 Men1 Cdkn2b Ccnc Cdk8 Mapk1 Hdac1 Smad4 Tfdp2 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation Jak1 Tyk2 Map2k1 Ptpn11 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat Polr2k Polr2g Gtf2f1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Cdkn2a P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events Mapk14 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere Rpa2 Pold4 Rpa3 Terf2 Pcna Wrn Terf2ip DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency Tcn2 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication Mgme1 Polg2 Twnk VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation Ap2a2 Ap2a1 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis Myh9 Wasf3 Wasf2 Ptk2 Abi2 Dock1 Nckap1l Arpc4 Wipf3 Crk Mapk1 Actr2 Myo10 Actr3 Myo5a Was Cd3g Btk BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs Cyp2d22 Cyp2c65 Ltc4s ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants Alk CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA Nkiras2 Myd88 Aim2 Tbk1 Trex1 Ctnnb1 Nlrc3 Nlrp4e Trim21 Cgas Ripk1 Polr3a Polr3d Polr2k Polr3f Dhx36 Polr3k Prkdc Nkiras1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors Gng3 Gnb2 Gnb1 Gnb4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins Tfdp1 Akt3 Akt2 Akt1 Dynll1 Dynll2 Tfdp2 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 Bdnf SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Cdk6 Cdkn2a TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation Rpl4 Tufm Psmb1 Psmc2 Tcf25 Serp1 Rpl39 Psma7 Aimp1 Rpl7 ATP6 Srp9 Pabpc1 Srp68 Rpl22 Rbx1 Eif5b Rps25 Gars1 Rps26 Yars1 Vars1 Sec61a2 Rps27 Farsa Tars1 Rps21 Etf1 Eef1g Gspt1 Eif3l Eif3e Rchy1 Eif4ebp1 Mtrf1l Mrpl33 Eif3b Tsfm Eif3c mt-Nd4l Mrpl11 Mrpl34 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mrpl47 Mrpl49 Mrps23 Mrps28 Mrpl52 Ascc2 Eif2b4 Eif2s3x Eif2s2 Eif2b1 Rpl18 Iars1 Eif4b Eif4e Trmt112 Ppa1 Ppa2 mt-Cytb mt-Nd4 Aars2 mt-Nd5 Wars2 mt-Nd6 Pars2 Yars2 Ears2 Psmd12 Psmd11 Psma6 Rps11 Psmd8 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants Flt3 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling Camk2g Camk2d Camk2b Clcn6 Camk2a Apbb1ip Zc3hav1 Phb1 Fgb Mras Fga Csk Fgg Agtrap Nf1 Spred1 Spred3 Spred2 Ap3b1 Dusp10 Arrb1 Map3k11 Rap1a Ppp1cc Map2k2 Map2k1 Mapk1 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses Tbk1 Nup133 Jak1 Tyk2 Irak1 Il17f Rigi Il17a Ifna16 Tlr7 Pik3r4 Tab2 Nup205 Nup107 H2-Q10 Sec13 Ube2v1 Nod1 Nup85 Ripk2 Sftpd Nup88 Ptpn11 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate Dolpp1 Dhdds DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 Fgfr3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes Me1 Idh1 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin Acvr1b Mapk1 Smad4 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer Smad4 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression Nkx2-5 Tbx5 Hipk1 Tead4 Tead3 Tead2 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling Jak1 Il2rb Il2 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Slco1b2 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis Paics Ppat DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport Rhbg SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer Smad4 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells Hif3a Pou5f1 Epas1 Smad4 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization Nectin2 Nectin1 Nectin4 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans Tnn Matn1 Lama2 Itgav Tgfb2 Lrp4 Lamb2 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis Syt2 Ubqln2 Syt9 Cops8 Slc18a3 Cops7a Cops7b Il7r Stam2 Areg Ap2a2 Ap2a1 Arrb1 Cbl Sh3kbp1 M6pr Eps15 Wnt5a Cd3g Egfr Fzd4 Apob Picalm MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation Pnpt1 Rexo2 Lrpprc PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors Ptgir Ptger2 Ptger3 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis Cyp11b2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria Gbp2 Epcam MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development Ctnnb1 Akt3 Akt2 Aimp1 Pmel Dct Alx3 Stt3b Edil3 Kit Mitf Mapk14 Atp6v1a Iars1 Atp6v1h Tfeb Dicer1 Tnrc6a Zic1 Tcf7l1 Cdh2 Rab27a Asah1 Pxdn Bcl2a1d Mapk1 Cdkn2a Myo5a Hdac1 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling Tnfrsf10b DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells Fgf7 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants Dkk1 Kremen1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS Tbk1 Sap30 Jak1 Kdm1a Atp1a1 Tyk2 Comt Ap2a2 Ap2a1 Tlr7 Plcg2 Atp1b1 Atp1b3 Fkbp4 Cysltr1 Nr3c1 Rbx1 Btk Brms1 Rbbp7 Brd4 Blnk Gatad2a Ripk1 Sigmar1 Sh3kbp1 Sap30l Hmg20b Il1r1 Hdac1 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly H2bu2 Pck1 Rbbp7 Gatad2a H3c7 Pwwp2a Zmynd8 Tcf19 H2ax Ikzf1 Pwwp2b G6pc1 H2bc9 H2bc7 H2bc8 Hdac1 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants Cdc37 Erbin EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Pabpc1 Eif3l Eif2b4 Eif3e Eif2s3x Eif4ebp1 Eif2s2 Eif2b1 Eif3b Eif3c Rpl22 Rpl18 Eif4b Eif4e Eif5b Rps11 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes Tkt Taldo1 G6pdx TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Kit Egfr Yy1 Atad2 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification Atp6v1h MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol Rpl4 Xrn2 Rpl39 Rpl7 Exosc9 Isg20l2 Nip7 Exosc8 Bysl Riok2 Exosc4 Gnl3 Ebna1bp2 Dis3 Exosc6 Exosc1 Exosc2 Rpl22 Rpl18 Csnk1d Mphosph6 Rps25 Rps26 Noc4l Rps27 Pdcd11 Imp4 Dcaf13 Utp6 Rrp9 Utp14a Nop58 Rpp21 Rps21 Ddx49 Rcl1 Rpp14 Utp11 Rpp40 Bms1 Ddx52 Wdr75 Rps11 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling Rgmb Rgma Trpc6 Slit1 Ablim3 Dcc Ptk2 Unc5c Slit3 Dock1 Myo10 Dscaml1 Ptpn11 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants Flt3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding Tuba1a Tubal3 Gng3 Gnb2 Xrn2 Gnb1 Sphk1 Pdcl Gnb4 Cct7 Csnk2b Ccne1 Kif13a Tubb2a Gna14 Ap3m1 Fbxw4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Nedd1 Actr1a EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER Ercc3 Rfc1 Pold4 Rfc5 Xab2 Rfc3 Rfc4 Rfc2 Pcna Usp7 Polr2k Polr2g Rpa2 Isy1 Gtf2h2 Rpa3 Gtf2h3 Gtf2h5 Rbx1 Ddb1 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions Scn8a Sptbn4 Sptb Shtn1 Itgav Rdx Scn11a Sptan1 Ap2a2 Dpysl2 Ap2a1 Csnk2b Ranbp9 Map2k2 Cntn6 Map2k1 Mapk1 Ank1 Egfr L1cam DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME Acsm5 Pck1 Gstt1 Adal Pon3 Pon1 Ggt1 Ugt2a1 Ugt2a2 Glyatl3 Ugt2b1 Hsd11b1 Sult1e1 Glyat Nme1 Ada Cyp2d22 Cyp2c65 Xdh Ugt1a2 Slco1b2 Slc29a3 Slc28a2 Ces2h Acsm4 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores Nuf2 Nup133 Dync1h1 Dynll1 Dync1i2 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cenpa Nsl1 B9d2 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Nudc Kif2c Ppp1cc Nup85 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding Tubal3 Tuba1a Cct7 Tubb2a SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression H2bu2 H2ax H2bc9 Taf1d H2bc7 H2bc8 H3c7 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer Cbl Cdc37 Gab1 Areg Egfr Pik3r1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants Alk SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Kit Pik3r1 CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic Cdk6 Psmb1 Psmc2 Rab1b Psma7 Rfc5 Mybl2 Rfc3 Rfc4 Rfc2 Cdkn2c Rpa2 Akt1 Rpa3 Wapl E2f6 Stag2 Smc3 Rbx1 Cdk11b Rfc1 Pold4 Nup205 Nup107 Sec13 Ppp1cc Rcc1 Nup85 Chmp3 Nup88 Chmp6 Nup133 Lemd3 Ppp2r5e Ppp2r5d Ppp2r5c Tyms Ppp2r5b Ppp2r5a Prkcb Nek9 Nek6 Ska1 Ahctf1 Dynll2 Csnk2b Gorasp1 Tubgcp5 Ube2c Tubgcp4 Lpin1 Nudc Fzr1 Anapc11 Anapc10 Cdkn2a E2f2 Anapc1 Nedd1 Actr1a Tuba1a Nuf2 Cdk5rap2 Cep250 Akt3 Sdccag8 Emd Akt2 Dync1h1 Ajuba Cep78 Gmnn Pcm1 Dctn2 Orc1 Orc2 Cep164 Foxm1 Ssna1 Cpap Tubg1 Dynll1 Ccnb2 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Cnep1r1 Haus5 Csnk1d Btrc Cenpa Nsl1 Pkmyt1 Ncapd3 Mau2 B9d2 Rps27 Taok1 Cenpm Lbr Cenpi H2ax Hmmr Golga2 Cenpf Pola2 Kif18a Kif2c Ccne1 Tubb2a Hdac1 Tubal3 H2bu2 E2f3 Tfdp2 Tfdp1 Lcmt1 Ptk6 H2bc9 H2bc7 H2bc8 Phlda1 Pcna H3c7 Cdkn2b Gins2 Gins1 Mcm8 Cdc45 Mapk1 Ppp2r2a Psmd12 Psmd11 Psma6 Ccna1 Psmd8 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA Nup205 Nup133 Nup107 Sec13 Eif4e Nup85 Nup88 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F12 F2 Klkb1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing Ptk6 Sfpq SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) Bdnf Cdk5 Gab1 Frs2 Ptpn11 Pik3r1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 Psmb1 Psmc2 Psma7 Ube2c Fzr1 Anapc11 Ccne1 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Actn1 Tesk1 Parva Parvb HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) Exo1 Rfc1 Polh Pold4 Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Pcna Wrn Rpa2 Rad9a Bard1 Eme1 Rbbp8 Mus81 Palb2 Rpa3 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes H2bu2 Ajuba Ccnc Med16 Med17 Elovl5 Ncoa6 Cidec H2bc9 H2bc7 H2bc8 Fabp4 Med31 Ppargc1b Phlda1 Cdk8 Cdk5 H3c7 Mgll H2ax Med23 Lpin1 Med24 Plin2 Dgat2 Scd1 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling Csf2ra Cbl Jak1 Il2rb Blnk Crk Csf2 Il2 Tec Ptpn11 Pik3r1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling Areg Egfr LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Ctnnb1 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle Noxa1 Emd Git1 Iqgap2 Iqgap3 Arhgap15 Diaph3 Arhgap17 Fam13b Arhgap22 Baiap2l1 Ophn1 Was Nhs Prex1 Wasf3 Wasf2 Dock7 Plekhg1 Farp1 Sh3bp1 Abi2 Lbr Pkn2 Pkn1 Arhgap42 Racgap1 Ktn1 Lemd3 Srgap1 Srgap2 Cdc42bpa Cdc42ep1 Dock1 Rab7 Nckap1l Erbin Wipf3 Bcr Jag1 Arap2 Syde2 Mcam Abl2 Pik3r1 Rasgrf2 Cyba Cybb Nox3 Spata13 Arhgef15 Arhgef11 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping Cyba Noxa1 Jun Wnt5a Fzd7 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO Arrb1 Cdon TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis St3gal4 St6galnac3 Muc1 St3gal1 St6gal1 Muc4 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions Grpel1 Ctnnb1 Hnrnpr Elavl2 Nrbp1 Mlst8 Sugp1 Camk2g Ctr9 Camk2d Nudt21 Camk2b Pik3r4 Camk2a Srrm2 C1qa Sdc3 Mapkap1 Prpf6 Prpf8 Gpc3 Wbp11 Gpc2 Gpc4 Pqbp1 Cgas F2 Taok1 Mmp9 Polr2g Hnrnpa1 Gtf2f1 H2bu2 Pdcd6ip Polr2k Phf5a Rpl18 Pabpn1 H2bc9 H2bc7 Fasn H2bc8 Snrpa1 Dhx38 Hnrnpa2b1 U2af1l4 Xab2 Sf3b6 Ctnnbl1 Snrpn Apoa1 Cherp Ripk1 Tlr4 H3c7 Ly96 Isy1 Puf60 Ppil4 Ppil1 Cog1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation Nkiras2 Tab2 Usp14 Ube2v1 Nod1 Irak1 Traf2 Ripk2 Nkiras1 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer Tyk2 Foxm1 Jun Hip1 Strn Npm1 Tpm3 Dctn1 Rnf213 Prkar1a Rbx1 Bcl11a Sec31a Icos Myh9 Gzmb Alk Irs1 Frs2 Eef1g Pik3r1 Bcl2a1d Mapk1 Mdm2 Gcc2 Hdac1 Prf1 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases Mef2c Ppp2r5d Jun Mapk1 Mapk14 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription Tead4 Tead3 Tead2 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle Racgap1 Emd Mcam Cpne8 Lemd3 Diaph3 Arhgap17 Efhd2 Pik3r1 Actn1 Lbr Rab7 Plxna1 Rhod DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling Dock1 Ablim3 Dcc Ptk2 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste Tas2r13 Tas2r137 Calhm1 Gnb1 Tas2r136 Tas2r140 Trpm4 Tas2r119 Tas2r4 Tas2r39 Tas2r7 Tas2r38 Tas2r120 Tas2r107 Tas1r1 Tas1r3 Tas2r16 Tas2r40 Tas2r41 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Slc40a1 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements H2bu2 Rbbp7 Zfp141 Zfp324 Gatad2a Mphosph8 Zfp454 H3c7 Znf382 H2ax H2bc9 H2bc7 H2bc8 Morc2a Hdac1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation H2bu2 H2ax Nthl1 H2bc9 H2bc7 Terf2 H2bc8 Terf2ip SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors Rpl4 Psmb1 Psmc2 Ldb1 Rpl39 Psma7 Rpl7 Cap2 Dcc Srgap1 Srgap2 Pabpc1 Slit3 Evl Rhoa Rpl22 Rpl18 Prkar2a Akap5 Prkacb Rbx1 Rps25 Rps26 Rps27 Hoxa2 Slit1 Msi1 Abl2 Col4a5 Rps21 Lhx2 Etf1 Upf3a Gspt1 Psmd12 Ppp3cb Psmd11 Psma6 Rps11 Psmd8 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway Pgm2 Tkt Rpe Taldo1 Dera G6pdx Shpk TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling Adam17 Tbk1 Tnfrsf1a Sharpin Birc3 Mib2 Birc2 Traf2 Ripk1 Tab2 Sppl2b Otulin Sppl2a Nsmaf Ube2l3 Tnf RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events Mllt3 Ercc3 Ssrp1 Taf7 Taf5 Taf2 Ctr9 Ell Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Aff4 Gtf2h5 Taf13 Taf12 Supt6 Gtf2f1 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A Ube2c Anapc11 Anapc10 Anapc1 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 Srgap2 Srgap1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora Nhlrc1 Ppp1r3c DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription Flt4 Mamld1 Hes5 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions Sgca Trappc4 Itgav Sntg2 Actn1 Lama2 Sdc3 Ddr1 Dtna Snta1 Lamb2 Sspn Itgb4 Sntb2 Sntb1 Sgcd Sgcb REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation Myh9 Wasf3 Wasf2 Nf2 Ptk2 Abi2 Dock1 Nckap1l Arpc4 Wipf3 Crk Cfl1 Mapk1 Actr2 Myo10 Actr3 Myo5a Was Cd3g Btk DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling Psmb1 Psmc2 Psma7 Pik3r1 Cdc34 Tab2 Btrc Ube2v1 Psmd12 Cd3g Psmd11 Ripk2 Psma6 Psmd8 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs Rhoa Myh10 Myh9 Cfl1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions Sdk1 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription Hdac5 Rbbp7 Kdm1a Jun Lamtor2 Mlst8 Gatad2a Ezh2 Egr1 Snai1 Cbx4 Mapk1 Bmi1 Phc3 Hdac1 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling Cbl Klb Fgf15 Mapk1 Frs2 Ptpn11 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors Chrnd Chrnb2 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling Pck1 Kdm1a Kdm1b Apoe Tnrc6a Apoc2 Eepd1 Ugt1a2 Kdm3a Nrip1 Apoc1 Fasn Fabp6 Scd1 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs Rit2 Rap1a Map2k2 Crk Map2k1 Mapk1 Mapk14 Frs2 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE Gpcpd1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) Rpa2 Rad9a Exo1 Bard1 Rbbp8 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Wrn ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria Dynll2 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis Rab7 Rnf213 Nos2 Sfpq Atp6v1h Coro1a Vps33b EG433182 Mapk1 Ctsg TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation Tbk1 Traf2 Rigi Ifna16 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin Mau2 Wapl Stag2 Smc3 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility Lama2 Rap1a Lamb2 Crk Hgf Dock7 Gab1 Ptk2 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins Gpc3 Gpc2 Gpc4 Clps Retsat Apoa1 Apoa2 Apoe Apoa4 Apoc2 Sdc3 Vkorc1l1 Apoc3 Apob MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle Mdh1 Mdh2 Slc25a18 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins Entpd4 Entpd8 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle Racgap1 Ktn1 Iqgap3 Diaph3 Srgap1 Daam1 C1qbp Abcd3 Arhgap22 Rhoa Erbin Tex2 Vma22 Bcr Pkn3 Ophn1 Stom Arap2 Emc3 Atp6ap1 Mcam Myo9a Prex1 Actc1 Farp1 Pik3r1 Rasgrf2 Lbr Pkn2 Pkn1 Arhgap42 Arhgef15 Arhgef17 Arhgef11 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Pbrm1 Auts2 Csnk2b Rybp Cbx4 Bmi1 Phc3 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2bu2 Kdm1a Myh10 Myh9 H3c7 Pkn2 Pkn1 H2ax Rhoa H2bc9 H2bc7 Pkn3 H2bc8 Ar LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization Cidec Fitm1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen Ca2 Cyb5r2 Cyb5r1 Ca1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling Flna Pik3r1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall Itgav Atp1b1 Sdc3 Pecam1 Atp1b3 Cd244 Spn Cd2 Selp Tek Itgam Slc16a3 Angpt4 Epcam Ptpn11 Slc7a7 Slc7a8 F2 Slc7a11 Ppil2 Tnfrsf10b Mmp1a Pik3r1 Jaml Cd84 L1cam Apob FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival Irak1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 Psmb1 Psmc2 Bach1 Chd6 Taldo1 Psma7 Slc7a11 Idh1 G6pdx Areg Tkt Btrc Nqo1 Me1 Psmd12 Rbx1 Psmd11 Psma6 Txnrd1 Psmd8 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins Nup205 Nup133 Nup107 Pml Sec13 Mdm2 Nup85 Nup88 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response Flna Oas2 Rnasel Rigi VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium Pkd2 Rab11a Exoc7 SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection Chmp6 Tbk1 St6galnac3 Rigi St6gal1 Tlr7 Npm1 Pik3r4 Ganab Pals1 Ppig Ppih Sftpd Itch Pycard Rps25 Casp1 Rps26 St3gal4 Rps27 St3gal1 Rps21 Ifit3b Hnrnpa1 Ppib Chmp3 Rps11 Smad4 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Psmb1 Psmc2 Psma7 Btrc Psmd12 Psmd11 Rbx1 Psma6 Psmd8 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism Slc35d2 B3gnt2 St3gal4 Chst2 St3gal6 Hexb St3gal1 B4galt6 Gns ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport Slc22a18 Slc47a1 Slc25a26 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer Rac2 Pik3cg Klb Hgf Fgf15 Kit Gab1 Irs1 Areg Frs2 Pik3r5 Strn Pik3r1 Flt3 Fgf7 Bdnf Fgf22 Irs2 Egfr Ptpn11 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs Rab38 Trappc4 Trappc11 Akt3 Akt2 Rab1b Ankrd27 Rin2 Rab14 Rab7 Akt1 Rab5c Gdi1 Dennd6a Dennd6b Dennd2b Trappc10 Dennd4b Rab9 Dennd2d Rab27a Trappc6b Rab13 Trappc6a Trappc8 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation Snai1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression Ptk6 Epas1 Nr3c1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases Slitrk6 Slitrk3 Ppfia2 Lrrc4b Ppfia4 Slitrk2 Slitrk5 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition Tuba1a Psmb1 Psmc2 Cdk5rap2 Cep250 Sdccag8 Dync1h1 Psma7 Ajuba Cep78 Mybl2 Pcm1 Dctn2 Cep164 Ssna1 Foxm1 Cpap Tubg1 Dynll1 Ccnb2 Alms1 Dync1i2 Cep135 Lcmt1 Cep63 Cep152 Haus4 Haus5 Csnk1d Btrc Rbx1 Cdk11b Pkmyt1 Phlda1 Tubgcp5 Hmmr Cenpf Tubgcp4 Fzr1 Psmd12 Ppp2r2a Psmd11 Nedd1 Psma6 Ccna1 Actr1a Psmd8 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters Mterf1b Tfb2m DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass Rfc1 Usp10 Polh Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Pcna Mad2l2 Uba7 Rev1 Rpa2 Ube2b Rchy1 Rpa3 Rbx1 Ddb1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors Chrna9 Chrnd Chrnb2 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions Med31 Gpc3 Gpc2 Gpc4 Ccnc Jak1 Cdk8 Oas2 Tyk2 Med16 Med17 Rigi Ifna16 Tlr4 Ly96 Tlr7 Med8 Sdc3 Med23 Med24 Rbx1 Med28 SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes Catsper4 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement Psmb1 Psmc2 Ctnnb1 Psma7 Jak1 Tyk2 Birc2 Cdh11 Dock1 Psmd12 Psmd11 Psma6 Psmd8 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling Akt1s1 Eif4ebp1 Eif4b Eif4e Lamtor2 Mlst8 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling Ptpn20 Tbk1 Casp1 Il18r1 Ptpn13 Ptpn2 Ptpn7 Ptpn11 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 Jag1 Psmb1 Psmc2 Ctnnb1 Psma7 Mamld1 Tead3 Tead2 Brd2 Tcf7l1 Tead4 Psmd12 Mdm2 Psmd11 Psma6 Zfhx3 Psmd8 Smad4 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling Psmb1 Psmc2 Rag2 Rag1 Psma7 Jun Tnrc6a Mapk4 Etv4 Psmd12 Prkacb Psmd11 Psma6 Psmd8 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Csnk2b Csnk1d Cdk5 Ppp1cc Cry1 UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle Nmral1 Arg2 Nags Asl DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias Slc26a2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones Inhbc PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer Rac2 Akt3 Akt2 Klb Fgf15 Kit Mlst8 Strn Pik3r5 Flt3 Akt1s1 Mapkap1 Akt1 Ptpn11 Pik3cg Hgf Gab1 Irs1 Areg Frs2 Pik3r1 Fgf7 Bdnf Fgf22 Tsc2 Irs2 Mdm2 Egfr NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly H2bu2 Rbbp7 Ruvbl1 Mis18a Npm1 Rsf1 Cenpm Cenpi H2ax Cenpa H2bc9 H2bc7 H2bc8 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE Pla2g3 Lpcat4 Plaat3 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) Psmb1 Psmc2 Psma7 Btrc Psmd12 Nfkbie Ppp3cb Rel Psmd11 Prkcb Psma6 Psmd8 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG Ptpmt1 Pgs1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs Cyp2d22 Cyp2c65 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity METHYLATION%REACTOME%R-HSA-156581.6 Methylation Mat2a Trmt112 As3mt Ahcy Mtr Comt ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation Rap1a Crk EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Cdkn2a FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion Ffar1 Gna14 Acsl3 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein Edem2 Magt1 St3gal4 St6galnac3 Mgat4a Mgat4b St3gal1 Stt3b St6gal1 Zdhhc3 Tmem258 Ganab Rpn2 Zdhhc9 Rpn1 Golga7 Mgat5 Dad1 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation Uqcrc2 Mdh2 Arg2 Mrps2 Ogdh ATP6 Prelid1 Idh2 Hspa9 Hsd17b10 mt-Nd5 Twnk mt-Nd6 Lonp1 Spg7 Ndufb6 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease Erlin2 Zmym2 Gab1 Frs2 Pik3r1 Polr2k Fgf7 Polr2g Fgf22 Bcr Gtf2f1 Fgfr3 Fgfr1op2 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade Nkiras2 Tbk1 Usp14 Birc3 Jun Irak1 Birc2 Traf2 Ripk1 Mapk14 Tlr4 Map3k8 Ly96 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ripk2 Nkiras1 Ptpn11 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer Mapk1 Pik3r1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC Tuba1a Cct7 Tubb2a ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 Gng3 Gnb2 Gnb1 Gnb4 Gnai2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells Areg GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling Egfr IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) Myd88 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation Racgap1 Sec31a Dync1h1 Lgmn Dctn2 Ap1s3 Dynll1 Ctsa Dynll2 Ap2a2 Ap2a1 Dync1i2 Rab7 Ctsf Sec13 Dctn1 Kif18a Ctsh Kif2c Klc2 H2-Oa Capza1 Actr1a Actr10 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus Pip4k2c FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins Adarb1 Adar PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor Ptgir Gng3 Gnb2 Gnb1 Gnb4 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle Racgap1 Ktn1 Git1 Iqgap2 Iqgap3 Diaph3 Arhgap17 Srgap1 Fam13b Srgap2 Fnbp1 Cdc42bpa Daam1 Cdc42ep1 Arhgap22 Rab7 Wipf3 Bcr Ophn1 Was Stom Arap2 Prex1 Cpne8 Dock7 Plekhg1 Farp1 Pik3r1 Rasgrf2 Lbr Map3k11 Spata13 Arhgap42 Arhgef15 Arhgef11 Arhgdig SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants Cdc37 Erbin Egfr CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction Scn8a Kcnk7 Kcnk6 Kcnip3 Atp1a1 Scn11a Ahcyl1 Camk2g Camk2d Camk2b Camk2a Nkx2-5 Atp1b1 Tbx5 Atp1b3 Hipk1 Orai2 Stim1 Nppc Kcnk9 Atp2b2 Atp2b1 Slc8a1 Slc8a2 Kcnk4 Kcnq1 Kcnk2 Kcne5 Tnni3 Kcnk10 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence H2bu2 Cdk6 Mink1 Map3k5 H1f2 H1f3 Jun Terf2 Cdkn2c Terf2ip Mapk14 E2f3 Tfdp2 Tfdp1 Map4k4 Hmga2 H2bc9 H2bc7 H2bc8 Rbbp7 Ezh2 H3c7 Tnrc6a Cdkn2b H2ax Ube2c Fzr1 Cbx4 Anapc11 Ccne1 Anapc10 Mapk1 Bmi1 Cdkn2a Mdm2 E2f2 Anapc1 Asf1a Phc3 H1-5 Ccna1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange Rpa2 Rad9a Exo1 Bard1 Rbbp8 Palb2 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Wrn SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane Pik3r4 Pi4k2b DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE Mtr MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins Ubap1 Tsg101 Mvb12a EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects Cdk6 Cdkn2a NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 Psen2 Notch3 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript Ell Polr2k Ercc3 Polr2g Ssrp1 Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers H2bu2 Pck1 Ssrp1 Tcf3 Myog Ctnnb1 Myod1 Axin2 Ctr9 Pwwp2a Phf5a Zmynd8 Tcf19 Ikzf1 Pwwp2b Adnp G6pc1 H2bc9 H2bc7 H2bc8 Snrpa1 Bcl11a Fam124b Pbrm1 Rbbp7 Chd6 Igf2 Phf10 Sf3b6 Snrpn Gatad2a Cherp H3c7 H2ax Puf60 Nqo1 Hdac1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK Prkag3 Strada Tsc2 Cab39l Prkag2 Lamtor2 Mlst8 Cab39 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs Psmb1 H2bu2 Psmc2 Tcf3 Ldb1 Psma7 Gata1 H3c7 Myb H2ax H2bc9 H2bc7 Psmd12 H2bc8 Psmd11 Psma6 Psmd8 Itch NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage Uck2 Ada Ampd3 Adal Ampd2 Upp2 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI Rpa2 Rfc1 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna Mad2l2 Rev1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus Akt3 Akt2 Akt1 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling Camk4 Camk2a Camkk2 Ahcyl1 Prkar2a Pde1a Prkar1a Prkacb Camk2g Camk2d Camk2b LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis Nrip1 Fasn Scd1 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis Stard3nl Stard3 Akr1b1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway Fga Psmb1 Psmc2 Myd88 Fgg Psma7 Sec22b Sec61a2 S100a1 Tlr4 Ly96 H2-Q10 S100a9 Psmd12 Psmd11 Psma6 Btk Fgb Psmd8 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants Flt3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes Hsp90b1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling Psmb1 Psmc2 Itk Psma7 Ahcyl1 Jun Ms4a2 Tec Pik3r1 Txk Cdc34 Plcg2 Tab2 Btrc Ube2v1 Mapk1 Psmd12 Ppp3cb Psmd11 Psma6 Btk Psmd8 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade Jun Mapk14 Map3k8 Mef2c Ppp2r5d Btrc Ube2v1 Nod1 Ripk2 Btk Nkiras1 Fgb Nkiras2 Fga Peli1 Myd88 Usp14 Fgg S100a1 Irak1 Traf2 Tlr4 Ly96 Tab2 S100a9 Map2k1 Mapk1 Ecsit CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism Chsy3 Hexb Cspg5 Hyal3 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic Kif12 Racgap1 Kif1c Dync1h1 Kif21b Rab1b Dctn2 Kifc5b Kif27 Dynll1 Dync1i2 M6pr Rhobtb3 Dctn1 Man1a Sec22b Bicd2 Bicd1 Rint1 Pafah1b2 Use1 Rab43 Vps52 Kdelr2 Tmed9 Dynll2 Naa38 Naa30 Arfip2 Snap29 Rab9 Cyth4 Kif18a Rab36 Kif2c Cog2 Cog6 Bet1l Cog8 Klc2 Gcc2 Capza1 Actr1a Actr10 Cog1 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease Taldo1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF Thbs4 Plat Col4a4 Col6a3 Crk Col4a5 Thbs2 Ptpn11 Plg Pik3r1 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle Ppfia2 Ppfia4 Cplx1 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling Prtn3 Ifnlr1 Jak1 Tyk2 Casp3 Il34 Il10rb PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation Kin Mettl22 Eef2kmt Eef1akmt2 Eef1akmt1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane Ppp2r5e Frat2 Wnt8a Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis Dhrs7b PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling Pde3b Akt2 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism Mbtps1 Apoa1 Ap2a2 Apoa2 Apoe Ap2a1 Apoa4 Apoc2 Apobr Apoc3 Apoc1 Prkacb Mttp Apob ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN Bdnf RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE Polr2k Ercc3 Polr2g Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing Rpl4 Rpl39 Rpl7 Exosc9 Exosc8 Exosc4 Dis3 Exosc6 Exosc1 Rpl22 Exosc2 Csnk1d Mphosph6 Trmt10c Prorp Elac2 Rps25 Rps26 Rps27 Rps21 Xrn2 Isg20l2 Nip7 Bysl Riok2 Gnl3 Ebna1bp2 Rpl18 Noc4l Pdcd11 Imp4 Dcaf13 Trmt112 Utp6 Rrp9 Utp14a Nop58 Rpp21 Ddx49 Rcl1 Nop10 Utp11 Rpp14 Dkc1 Rpp40 Hsd17b10 Bms1 Ddx52 Nat10 Wdr75 Ngrn Rps11 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system H2bu2 F12 C1qbp H2ax H2bc9 H2bc7 H2bc8 Prcp Klkb1 H3c7 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F10 F2 F9 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism Lgmn Vdr AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy Dync1i2 Dync1h1 Ube2v1 Dynll1 Dynll2 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections Npm1 Plcg2 Akt1 Fkbp4 Rbx1 Brms1 Itch Nup205 Nup107 Sec13 Ifit3b Ppib Nup85 Chmp3 Nup88 Chmp6 Nup133 Atp1a1 Rigi Comt Ap2a2 Ap2a1 Atp1b1 Atp1b3 Cysltr1 Nr3c1 Btk Brd4 Sigmar1 Sh3kbp1 Il1r1 Mgat5 Dad1 Rps11 Tufm Edem2 Tbk1 Akt3 Akt2 Jak1 St6galnac3 Iscu Tyk2 Vps33a Vps33b Stt3b Ano6 St6gal1 Ifna16 Tlr7 Zdhhc3 Pik3r4 Ganab Rpn2 Sdc3 Zdhhc9 Rpn1 Vps11 Ube2v1 Nod1 Pals1 Ppig Vps16 Ppih Golga7 Ripk2 Sftpd Ptpn11 Gpc3 Gpc2 Pycard Magt1 Gpc4 Rps25 Casp1 Rps26 St3gal4 Rps27 Blnk Mgat4a Mgat4b St3gal1 Irak1 Il17f Rps21 Il17a Srpk1 Gemin2 Tmem258 Tab2 Ddx20 H2-Q10 Sap30l Hnrnpa1 Hmg20b Hdac1 Sap30 Kdm1a Rbbp7 Gatad2a Ripk1 Smad4 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors Npm1 Ing2 Ctbp1 Pcgf2 Cbx4 Nrip1 Pias3 Bmi1 Phc3 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions Sirpb1b Ptpn11 Ptk2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay Exosc9 Dcp2 Exosc8 Lsm2 Exosc4 Pabpc1 Dis3 Exosc6 Exosc1 Exosc2 Cnot7 Cnot6 Cnot9 Eif4b Eif4e PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors Pfkfb1 Ppp2r5d DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding Nthl1 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation Ercc3 Taf7 Taf5 Taf2 Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins Zmym2 Pik3r1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2bu2 Polr2k Rbbp7 H2ax H2bc9 Mybbp1a Taf1d H2bc7 H2bc8 Gatad2a Hdac1 H3c7 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Gabbr2 Gng3 Gnb2 Gnb1 Gnb4 Kcnj3 Kcnj10 Kcnj5 Kcnj15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock Psmb1 Psmc2 Psma7 Cdk5 Mef2c Csnk2b Ncoa6 Crtc3 Csnk1d Rai1 Btrc Nrip1 Ppp1cc Bmal2 Crtc1 Cry1 Cpt1a Tfeb Psmd12 Rbx1 Psmd11 Psma6 Psmd8 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis Akr1b1 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 Cyp11b1 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors Gabbr2 Gng3 Gnb2 Gnb1 Gnb4 Kcnj3 Kcnj10 Gnai2 Kcnj5 Kcnj15 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation Pde1a REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor Arnt Epas1 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine Adarb1 Adar AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen Fga Fgg Fgb PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation Ing2 Pip4k2c Pin1 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways Pdcd6ip Syt2 Ctnnb1 Stam2 Vps33b Cd9 Gbp2 Cbl Rab7 Sh3kbp1 Rnf213 Nos2 Sfpq Sv2a Atp6v1h Coro1a Map2k2 Eps15 Map2k1 Mapk1 EG433182 Ctsg Epcam Txnrd1 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN Psmb1 Psmc2 Rnf146 Psma7 Psmd12 Axin2 Psmd11 Psma6 Psmd8 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD Gpc3 Gpc2 Gpc4 Sdc3 Cspg5 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance H2bu2 Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Terf2 Atrx Wrn Terf2ip Polr2k Rpa2 Rpa3 Stn1 Dscc1 H2bc9 H2bc7 H2bc8 Rfc1 Pold4 Pcna Ruvbl2 Ruvbl1 Nop10 Polr2g Dkc1 H2ax Pola2 Ppp6c Ankrd28 Pif1 Ccna1 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling Flt3 Akt3 Csk Akt2 Cbl Akt1 Sh2b3 Abl2 Ptprj Ptpn11 Pik3r1 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD Bckdhb DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones Hsp90b1 Mbtps1 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia Psmb1 Hif3a Psmc2 Arnt Psma7 Limd1 Ajuba Epas1 Psmd12 Rbx1 Psmd11 Psma6 Psmd8 DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 Dhdds RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control Rpl4 Psmb1 Psmc2 Tcf25 Rps25 Rpl39 Psma7 Rps26 Rpl7 Rps27 Rps21 Ascc2 Rchy1 Rpl22 Rpl18 Psmd12 Rbx1 Psmd11 Psma6 Psmd8 Rps11 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function Cdh11 Cdh24 Ctnnb1 Cdh8 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling Fancb Fancc Jak1 Tyk2 Camk2g Ifna16 Camk2d Ilf3 Mt2 Camk2b Npm1 Camk2a Pml Ptpn11 Rps25 Casp1 Trim21 Rps26 Oas2 Adar Rps27 Eif4g3 Gbp2 Rps21 Gbp7 Eif3l Eif3e Nup205 Eif3b Nup107 H2-Q10 Eif3c Sec13 Ifit3b Trim8 Nup85 Nup88 Ilf2 Nup133 Sphk1 Ptpn2 Ifi35 Uba7 Rigi Egr1 Eif2s3x Eif2s2 Ppp2r5a Rnasel Eif4e Irf5 Flna Isg20 Trim62 Irf6 Irf9 Trim38 Kpna4 Trim31 Ip6k2 Mapk1 Pin1 Rps11 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation Rpl4 Rps25 Rpl39 Rps26 Rpl22 Rpl18 Rpl7 Rps27 Rps21 Rps11 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal Ascc2 Ascc1 Mgmt SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions Pycard Tbk1 Rps25 Casp1 Rps26 Rps27 Rps21 Rigi Tlr7 Npm1 Ifit3b Hnrnpa1 Pals1 Ppig Ppih Ppib Sftpd Rps11 Itch Smad4 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog Psmb1 Adam17 Ift122 Psmc2 Psma7 Syvn1 Hhat Arrb1 Btrc Ift52 Prkar2a Prkar1a Dzip1 Fuz Psmd12 Prkacb Rbx1 Psmd11 Psma6 Ift140 Psmd8 Itch Cdon CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects Pde10a Pde11a Kcnmb1 Pde1a Kcnmb4 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection P2rx7 Pycard Sugt1 Casp1 Gsdmd C3ar1 P2rx4 Ctsg PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly Psmb1 Psmc2 Psma7 Psmd12 Psmd9 Psmd11 Psmd10 Psma6 Pomp Psmd8 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors Scara5 Fth1 Hsp90b1 S100a9 Apoa1 Msr1 Apoe Apob Scgb3a2 Cd5l Hp LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase Psmb1 Psmc2 Akt3 Akt2 Psma7 Rfc5 Rfc3 Gmnn Orc1 Rfc4 Orc2 Rfc2 Tfdp2 Tfdp1 Rpa2 Ptk6 Akt1 Rpa3 Wapl Stag2 Smc3 Rbx1 Rfc1 Pold4 Pcna Gins2 Gins1 Mcm8 Cdc45 Pola2 Ube2c Fzr1 Anapc11 Ccne1 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling Btrc Prlr Rbx1 Ptpn11 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling Akt3 Pik3cg Trib3 Akt2 Map3k14 Mapkap1 Akt1 Mlst8 Pik3r5 Map3k8 Pik3r1 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events Pkmyt1 Mybl2 Cenpf Foxm1 Ccnb2 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism Uroc1 Carns1 Amdhd1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants Kit UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases Ptrh2 Psmb1 Usp44 Psmc2 Usp37 Usp20 Psma7 Usp25 Wdr20 Usp28 Usp12 Usp19 Stam2 Clspn Usp9x Usp15 Trrap Ruvbl1 Usp22 H2bu2 Vdac3 Birc3 Birc2 Axin2 Rigi Il33 Rnf146 H2bc9 H2bc7 Polb Ar H2bc8 Usp10 Usp14 Vdac1 Traf2 Ripk1 Usp7 Otub1 Arrb1 Rce1 Tgfbr1 Psmd12 Mdm2 Psmd11 Psma6 Ccna1 Psmd8 Smad4 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS Muc1 Muc4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events Pde3b Akt2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis Abcd3 Apoa1 Abca2 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation Rac2 Tgfb2 Wdr1 Ola1 Nhlrc2 Calu Endod1 Lefty2 Mapk14 Sytl4 Clec3b Plcg2 Actn1 Manf Lgals3bp Apoh Pecam1 Apbb1ip Akt1 Dgkb Fgb Plg Ptpn11 Fga Csk Igf2 Fgg Prkch F2 Dagla Hgf Gnai2 Cd9 Cfd P2ry1 Dgkk Dgkz Psap F2rl2 Pdpn Gna14 Mpig6b Gng3 Gnb2 Lamp2 Adra2a Gnb1 Gnb4 Pik3r5 Rhoa Cyb5r1 Orm3 Crk Cfl1 Selp Prkcb Cd63 Flna Igf1 Pik3cg Trpc6 Apoa1 Pik3r1 Ptk2 Mgll Arrb1 Rap1a Ttn Mapk1 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) Cdk6 H2bu2 Jun Cdkn2c H3c7 Cdkn2b H2ax Ube2c Fzr1 Anapc11 H2bc9 Anapc10 H2bc7 Mapk1 Cdkn2a H2bc8 Anapc1 Ccna1 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders Camk4 Hdac1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines Tbk1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P Taldo1 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins Hgf SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer Cbl Cdc37 Gab1 Egfr Pik3r1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane Pi4k2b PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling Npm1 Ilf2 Eif2s3x Eif2s2 Fancb Fancc Sphk1 Ppp2r5a Adar Ptpn2 Ilf3 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function Ctnnb1 Zc3h12a Cdh19 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling Gng3 Gnb2 Akt3 Akt2 Gnb1 Sphk1 S1pr3 Mmp7 Gnb4 Gnai2 Areg Mmp9 Ptk2 Strn Pik3r1 Cav2 Akt1 Mapk1 Egfr REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL Nodal Dand5 Acvr1b Cer1 Lefty2 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG Mtr MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing Xrn2 Hnrnpr Sugp1 Nudt21 Polr2k Phf5a Srrm2 Pabpn1 Snrpa1 Prpf40a Ddx39b Dhx38 Thoc1 Hnrnpa2b1 Thoc3 U2af1l4 Srsf10 Thoc6 Snrpc Sf3b6 Snrpn Cherp Polr2g Puf60 Hnrnpa1 Gtf2f1 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport Emb Slc16a3 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL Ppp2r5e Ppp2r5d Ppp2r5c Pecam1 Ppp2r5b Ppp2r5a Mapk14 Apob Ptpn11 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing Hnrnpr Sugp1 Srrm2 Prpf6 Ppig Ppih Prpf8 Wbp11 Pqbp1 Polr2g Hnrnpa1 Gtf2f1 Polr2k Phf5a Prpf3 Snrnp25 Snrnp27 Cactin Pnn Ccdc12 Prpf40a Ddx39b Snrpa1 Rbmx2 Dhx38 Hnrnpa2b1 Nsrp1 Snrnp35 Srsf10 U2af1l4 Prpf4b Prpf18 Cwf19l2 Xab2 Snrpc Sf3b6 Ctnnbl1 Prpf38a Ppil2 Snrpn Steep1 Dhx35 Cherp Lsm2 Lsm8 Ppwd1 Isy1 Puf60 Ppil4 Ppil1 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase Comt Maoa FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) Sgca Lama2 Dtna Snta1 Lamb2 Sspn Sntb2 Sntb1 Sntg2 Sgcd Sgcb ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells Lama2 Lamb2 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants Flt3 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Polb DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate Aox1 Pdxk AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 Fgf7 Fgf22 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade Nkiras2 Peli1 Myd88 Usp14 Jun Irak1 Traf2 Mapk14 Map3k8 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ecsit Ripk2 Nkiras1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling Pik3r1 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) H2bu2 Xrcc4 Bard1 H2ax Prkdc Nhej1 Dclre1c H2bc9 Tdp2 H2bc7 Poll H2bc8 Herc2 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy Rab7 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter Polr3d Polr2k Polr3f Polr3k Snapc1 Snapc2 Brf2 Polr3a LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 Bckdhb COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism Mtr Mmab DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins Nup133 Xrcc4 Pcgf2 Nsmce1 Smc6 Nsmce4a Wrn Nup205 Pml Nup107 Sec13 Cbx4 Stag2 Smc3 Bmi1 Nup85 Phc3 Herc2 Xpc Nup88 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease Rpl4 Rpl39 Rpl7 Mlst8 Med8 Npm1 Plcg2 Pml Rpl22 Mapkap1 Fkbp4 Brms1 Ppib Med28 Phf5a Tyro3 Nckap1l Rpl18 Sv2a Wipf3 Actr2 EG433182 Actr3 Cldn1 Nr3c1 Btk Brd4 Xab2 Sf3b6 Ctnnbl1 Snrpn Mapre3 Bag2 Cherp Dynll2 Kpna4 Ptk2 Sigmar1 Ly6e Cyba Chmp1a Csnk2b Isy1 Arpc4 Sh3kbp1 Puf60 Ppil4 Ppil1 Il1r1 Egfr Cog1 Grpel1 Noxa1 Dync1h1 Hnrnpr Elavl2 Stam2 Sugp1 Ctr9 Dynll1 Nudt21 Dync1i2 Cd300a Srrm2 C1qa Btrc Prpf6 Ppig Ctsg Ppih Was Epcam Adam17 Prpf8 Wbp11 Rtn3 Syt2 Pqbp1 Cgas Oas2 Blnk Dnaja2 Wasf3 Eif4g3 Wasf2 Taok1 Cd9 Mmp9 Gbp2 Abi2 Med23 Sap30l Med24 Hdac1 H2bu2 Sap30 Ccnc Med16 Ahcyl1 Med17 Polr2k Gtf2h2 Gtf2h3 Gtf2h5 H2bc9 H2bc7 H2bc8 Med31 Ercc3 Rbbp7 Cdk8 Psip1 Gatad2a Apoa1 Ezh2 H3c7 Psmd12 Psmd11 Psma6 Psmd8 Smad4 Psmb1 Psmc2 Ctnnb1 Psma7 Nrbp1 Camk2g Camk2d Mapk14 Camk2b Pabpc1 Camk2a Akt1 Prkar2a Prkar1a Prkacb Rbx1 Itch F2 Gnai2 Ell Polr2g Ubap1 Nup205 Nup107 Tsg101 Sec13 Ifit3b Vps25 Taf11 Mvb12a Ppp1cc Taf13 Taf12 Rcc1 Gtf2f1 Nup85 Chmp3 Nup88 Chmp6 Pdcd6ip Ssrp1 Nup133 Xrcc4 Taf7 Nmt1 Taf5 Atp1a1 Taf2 Uba7 Rigi Comt Ap2a2 Ap2a1 Ggt1 Atp1b1 Atp1b3 Gnaz Cysltr1 Cd3g Dpep1 Ap1s3 Rab5c Pik3r1 Wnt5a Mgat5 Dad1 Txnrd1 Rps11 Fzd7 Tufm Edem2 Tbk1 Akt3 Akt2 Jak1 St6galnac3 Iscu Tyk2 Vps33a Vps33b Stt3b Ano6 St6gal1 Ifna16 Tlr7 Zdhhc3 Pik3r4 Ganab Rpn2 Sdc3 Zdhhc9 Rnf213 Rpn1 Vps11 Ube2v1 Nod1 Pals1 Vps16 Golga7 Ripk2 Sftpd Ptpn11 Gpc3 P2rx7 Gpc2 Pycard Magt1 Gpc4 Uba6 Sugt1 Rps25 Casp1 Rps26 St3gal4 Rps27 Mgat4a Mgat4b St3gal1 Irak1 Il17f Rps21 Il17a Srpk1 Gemin2 Tmem258 Tab2 Ddx20 H2-Q10 Hnrnpa1 Eps15 Hmg20b Myo10 Myo5a Gng3 Gnb2 Gnb1 Gsdmd Kdm1a Gnb4 Jun Dock1 Cbl C3ar1 Rab7 Nos2 P2rx4 Sfpq Atp6v1h Coro1a Pabpn1 Crk Eif4e Fasn Snrpa1 Dhx38 Hnrnpa2b1 U2af1l4 Myh9 Ripk1 Tlr4 Ly96 Map2k2 Map2k1 Mapk1 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses Pycard Tbk1 Casp1 Ifit3b Ppig Ppih Ppib Rigi Sftpd Itch Tlr7 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA Nup205 Nup133 Nup107 Sec13 Eif4e Nup85 Nup88 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate Slc35d2 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions Tsg101 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 Gpc3 Gpc2 Gpc4 Sdc3 Cspg5 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT Tomt Comt Maoa TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer Tgfbr1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy Chmp6 Tbk1 Lamp2 Tomm6 Dync1h1 Vdac3 Tomm7 Gabarap Atg5 Mlst8 Dynll1 Dync1i2 Pik3r4 Ube2v1 Epas1 Ube2l3 Atg101 Atg13 Atg3 Atg4a Atg4d Prkag2 Vdac1 Lamtor2 Dynll2 Ubap1 Csnk2b Prkag3 Tsg101 Tsc2 Mvb12a Plin2 Mfn1 Gabarapl2 Chmp3 Mfn2 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins Art1 Defb23 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Zfp473 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import Hscb Timm21 COA4 Grpel1 Chchd10 Tomm6 Timm17b Tomm7 Vdac1 Hspa9 Bcs1l Pmpcb Mtx2 Ndufb8 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport Rab38 Trappc4 Trappc11 Tbc1d10b Rab1b Ankrd27 Gabarap Tbc1d24 Rin2 Apoe Akt1 Gns Amph Cops8 Tbc1d4 Cops7a Cops7b C2cd5 Aspscr1 Slc2a4 Ubap1 Snap29 Tsg101 Sec13 Vps25 Mvb12a Chmp3 Hp Picalm Chmp6 Ap2a2 Ap2a1 Dctn1 Actr2 Actr3 Cd3g Sec31a Prkag2 Bloc1s1 Bloc1s3 Tbc1d8b Il7r Myo6 Dnajc6 Bloc1s4 Ap1s3 Dynll2 Tpd52l1 Rab5c Ap3b1 Fth1 Sort1 Hip1r Arrb1 Arpc4 Sh3kbp1 Gorasp1 Rab9 Ppp6c Lman2 Sec22c Wnt5a Sec23ip Ankrd28 Gcc2 Egfr Fzd4 Actr1a Cog1 Sptbn4 Akt3 Sptb Akt2 Dync1h1 Dctn2 Stam2 Dynll1 Sptan1 Hip1 Dync1i2 Fnbp1 Synj1 M6pr Rhobtb3 Csnk1d Syt2 Sec22b Areg Cyth4 Tsc2 Golga2 Rab36 Kif18a Cog2 Kif2c Cog6 Eps15 Bet1l Cog8 Klc2 Myo5a Capza1 Gjc2 Actr10 Gjb4 Kif12 Gja8 Racgap1 Kif1c Kif21b Ubqln2 Syt9 Slc18a3 Kifc5b Kif27 Msr1 Scgb3a2 Scara5 Hsp90b1 Ap1g2 Cbl Rab14 Rab7 Ank1 Man1a Ins2 Bicd2 Myh9 Bicd1 Pafah1b2 Rint1 Use1 Rab43 Vps52 Kdelr2 Apoa1 Tmed9 Naa38 Naa30 Gdi1 Arfip2 Dennd6a Dennd6b Dennd2b Trappc10 Prkag3 Dennd4b Gga3 Preb Dennd2d S100a9 Rab27a Tbc1d13 Rab11b Trappc6b Rab13 Rab11a Trappc6a Gabarapl2 Apob Cd5l Exoc7 Trappc8 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression Tnrc6a Tcf3 Myog Myod1 Smad4 Rara NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism Nme4 Nme1 Gda Adal Nme6 Ppat Entpd4 Upp2 Entpd8 Paics Uck2 Ada Tyms Xdh Ampd3 Rrm1 Ampd2 Txnrd1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling Psmb1 Psmc2 Psma7 Map3k14 Btrc Psmd12 Psmd11 Psma6 Psmd8 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres Rfc1 Pold4 Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Terf2 Pcna Ruvbl2 Ruvbl1 Terf2ip Wrn Nop10 Rpa2 Dkc1 Pola2 Ppp6c Rpa3 Stn1 Dscc1 Ankrd28 Pif1 Ccna1 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane Tmem258 Magt1 Rpn2 Pdcd1lg2 Jak1 Rpn1 Mib2 Stt3b Dad1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers Slc8a1 Slc8a2 Slc8b1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis Rfc1 Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Terf2 Pcna Terf2ip Wrn Rpa2 Pola2 Rpa3 Stn1 Dscc1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH Rpa2 Rchy1 Rfc1 Polh Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion Ubap1 Tsg101 Mvb12a FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling ATP6 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade Jun Mapk14 Map3k8 Tlr7 Mef2c Ppp2r5d Btrc Ube2v1 Nod1 Tasl Ripk2 Irf5 Nkiras1 Nkiras2 Peli1 Myd88 Usp14 Irak1 Traf2 Tlr4 Ly96 Tab2 Map2k1 Mapk1 Ecsit INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing Casp1 Gsdmd Ctsg SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions Actn1 Trappc4 Sdc3 Itgav Itgb4 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane Tuba1a Kif24 Cdk5rap2 Sclt1 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d B9d2 Tctn3 Rab11a Nedd1 Ahi1 Actr1a SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF Kdr Ctnnb1 Akt3 Akt2 Sphk1 Itgav Ahcyl1 Mlst8 Mapk14 Flt4 Dock1 Rhoa Nckap1l Mapkap1 Akt1 Crk Prkacb Prkcb Trib3 Wasf3 Sh2d2a Wasf2 Ptk2 Pik3r1 Abi2 Cyba Cybb INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters Slc4a3 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS Ptdss2 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation Plcg2 Jun Mapk1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling Fgf7 Fgf22 Cbl Mapk1 Frs2 Ptpn11 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins Casp3 Sptan1 Plec GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases Gaa Nhlrc1 G6pc1 Slc37a4 Ppp1r3c ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production Gng3 Gnb2 Gnb1 Gnb4 Prkar2a Prkar1a Gnaz Gnai2 Prkacb EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse Rhoa Myh10 Myh9 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases Casp2 Cradd Casp1 Pidd1 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC Cct7 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex Phf10 Bcl11a RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling Jag1 Mamld1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling Atp6ap1 Atp6v1a Atp6v0d2 Atp6v1h Atp6v1f Atp6v0a4 Tcirg1 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation Camk2a Lrrc7 Nrgn Camk2g Camk2d Camk2b MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 Gfpt1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events Gpc3 Chmp6 Gpc2 Pik3r4 Gpc4 Sdc3 Iscu Chmp3 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors Lmbrd1 Aox1 Slc5a6 Pdss2 Btd Pcx Acacb Retsat Pdxk Apoe Slc22a13 Sdc3 Akt1 Slc25a51 Nudt12 Aco1 Slc23a1 Slc46a1 Gpc3 Gpc2 Slc23a2 Slc19a1 Gpc4 Clps Spr Tcn2 Prss2 Nmnat2 Cyb5a Gch1 Mmab Coq8a Aldh1l1 Apoc2 Slc52a2 Mthfd1 Folr2 Vkorc1l1 Pank4 Ppcs Apoc3 Fasn Enpp2 Coq4 Coq6 Idh1 Apoa1 Apoa2 Apoa4 Pdzd11 Cd320 Mtr Apob NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway Casp2 Tab2 Casp1 Ube2v1 Card9 Birc3 Nod1 Irak1 Birc2 Ripk2 Mapk14 Itch ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB Trib3 Akt2 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines Psmb1 Oaz2 Psmc2 Agmat Psma7 Srm Nqo1 Psmd12 Psmd11 Psma6 Psmd8 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption Chia Slc5a1 Clps Lipf Pir Amy2a5 Guca2a G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase E2f3 Ccna1 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins Hsd17b4 Phyh CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly Tuba1a Kif24 Cdk5rap2 Sclt1 Cep250 Sdccag8 Dync1h1 Dynlt2b Ift43 Cep78 Pcm1 Ift81 Gmnn Ift56 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Ift52 Gmnc Mcidas Ccno Ift140 Ift122 B9d2 Myb Tfdp1 Dynll2 Tnrc6a Tctn3 Arl6 Pkd2 Mchr1 Bbs7 Rab11a Nedd1 Ahi1 Actr1a Exoc7 RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events Rdh12 Opn1sw CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin Tuba1a Vash1 Vash2 Agtpbp1 Ttll6 Tubb2a Agbl5 Ttll5 Agbl1 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease Erlin2 Zmym2 Bcr Gab1 Frs2 Pik3r1 Fgfr1op2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis Cyp11b1 Cyp11b2 Hsd11b1 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B F10 F11 F9 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 Fgf22 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking Nosip REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Cdh2 Pxdn Stt3b Edil3 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events Magt1 Mrs2 Rhbg Azgp1 Nipal1 Nipa1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs Elovl6 Elovl5 Hacd1 Elovl1 Acsl3 Tecr TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs Tbc1d10b Rab7 Gga3 Tsc2 Gabarap Tbc1d24 Tbc1d13 Rab11b Rab11a Rab5c Gabarapl2 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding Klb Fgf15 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus Jag1 Psen2 Mib1 Mib2 Jag2 Notch3 Egfr PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism Hsd17b4 Phyh Decr2 Amacr Hao2 Slc25a17 Crat Hacl1 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation Ogdh COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly Cox16 Timm21 Coa3 Cox6a1 Sco1 Cox6a2 Rab5if Higd2a Cox20 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression Exosc4 Dis3 Eif2s3x Exosc6 Eif2s2 Exosc1 Exosc2 Exosc9 Dcp2 Exosc8 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 Cdc37 Erbin SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins Nup205 Nup133 Nup107 Sec13 Pcgf2 Cbx4 Bmi1 Nop58 Nup85 Phc3 Nup88 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs H2bu2 Polr2k Polr2g Tnrc6a H2ax H2bc9 H2bc7 H2bc8 H3c7 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism Pipox Slc25a21 Aldh7a1 Crym TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex Tab2 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation Casp3 H1f2 H1f3 H1-5 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction H2bu2 Catsper4 Terf2 Cd9 Terf2ip H3c7 Rpa2 Sun1 Rbbp8 Stag3 H2ax Mlh3 Pou5f1 Rec8 Cbfa2t2 Rpa3 Smc1b Zp3 Stag2 H2bc9 Smc3 H2bc7 H2bc8 Pdpn CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling Dpysl3 Dpysl5 Crmp1 Cdk5 Plxna1 Dpysl2 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine Acsm5 Glyatl3 Glyat Acsm4 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG Mgll Pnpla3 Dgat2 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) Slc40a1 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants Ppp2r5e Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency Hibch ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding Gng3 Gnb2 Gnb1 Gnb4 Grik5 Grik4 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling Itch DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction Rdh12 Opn1sw MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins Opn4 Opn3 Opn1sw REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle Psmb1 Psmc2 Psma7 Ube2c Btrc Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome Nkiras2 Peli1 Myd88 Usp14 Jun Irak1 Traf2 Mapk14 Tlr4 Map3k8 Ly96 Tlr7 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ecsit Ripk2 Nkiras1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib Cdc37 Erbin ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex Tab2 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity F12 C1qbp Klkb1 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors Akt3 Akt2 Akt1 Pou4f1 Phf20 Banp Zfp385a NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK Rasgrf2 Prex1 Arhgef15 Arhgef17 Arhgef11 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking Gjb4 Gja8 Myo6 Gjc2 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER Parp2 Ercc3 Rfc1 Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Pcna Rpa2 Gtf2h2 Rpa3 Gtf2h3 Gtf2h5 Rbx1 Ddb1 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints Nuf2 Psmb1 Psmc2 Exo1 Dync1h1 Psma7 Cop1 Rfc5 Rfc3 Rfc4 Orc1 Rfc2 Orc2 Wrn Dynll1 Clspn Ccnb2 Mapk14 Zfp385a Dync1i2 Rpa2 Rbbp8 Btrc Rpa3 Cenpa Rbx1 Herc2 Nsl1 Pkmyt1 B9d2 Rps27 Taok1 Cenpm Cenpi Nup107 H2ax Sec13 Cenpf Kif18a Kif2c Ppp1cc Ccne1 Phf20 Nup85 H2bu2 Nup133 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a H2bc9 H2bc7 H2bc8 Ska1 Ahctf1 Pcbp4 Dynll2 Rad9a Bard1 Mcm8 Cdc45 Ube2c Nudc Anapc11 Anapc10 Psmd12 Mdm2 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription H2bu2 Ercc3 Rbbp7 Ubtf Taf1d Gatad2a H3c7 Polr2k H2ax Gtf2h2 Gtf2h3 Gtf2h5 H2bc9 H2bc7 Rrn3 H2bc8 Hdac1 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors Adra2a FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer Rbx1 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway Camk4 Camk2a Camkk2 Prkar2a Pde1a Prkar1a Prkacb Camk2g Camk2d Camk2b PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion Rab7 Coro1a Vps33b COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic Kif12 Racgap1 Kif1c Kif21b Rab1b Sec22b Rint1 Use1 Kifc5b Kif27 Kdelr2 Tmed9 Kif18a Kif2c Klc2 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology Rpl4 Hif3a Myog Rpl39 Myod1 Rpl7 Cacna1h Itgav Acvr1b Amh Cer1 Lefty2 Med8 Psen2 Rpl22 Nodal Ranbp9 Dand5 Kdm5b Hoxa2 Slit1 Msi1 Col4a5 Lhx2 Etf1 Upf3a Gspt1 Col4a4 Gfi1 Asah1 Col6a3 Krt4 Pxdn Krt2 Krt8 Krtap12-1 Dsp Krt9 Fli1 Med28 Krt20 Krt18 Krt16 Krt15 Adgrg6 Zfp423 Pkp4 Krt76 Mbp Krtap1-3 Krt85 Krtap2-4 Kit Pmp22 Srgap1 Srgap2 Snai1 Rpl18 Plxna1 Mesp1 Tbx1 Actr2 Actr3 Rara Myh10 Abl2 Ptk2 Plxnd1 Prnp Csnk2b Cacna1i Arpc4 Sh3kbp1 Bcl2a1d Dscaml1 Egfr L1cam Arhgef11 Reln Dok6 Scn8a Sptbn4 Sptb Rgmb Git1 Rgma Ajuba Shtn1 Epha5 Scn11a Ephb1 Ephb3 Ephb4 Cap2 Sptan1 Ablim3 Lama2 Evl Lamb2 Thrap3 Mmp9 H2ax Med23 Med24 Cbx4 Il13 Satb1 Bmi1 Tnf Phc3 Hdac1 Batf Yy1 H2bu2 Hdac5 Men1 Maf Klf13 Ccnc Med16 Med17 Mef2c Polr2k Nkx2-5 Ncoa6 Iars1 Tead4 H2bc9 H2bc7 H2bc8 Fabp4 Med31 Ins2 Rbbp7 Ppargc1b Ptgds Cdk8 Pcgf2 Cdk5 Gatad2a Ezh2 Tead2 H3c7 Rab27a Psmd12 Epha4 Psmd11 Psma6 Psmd8 Smad4 Psmb1 Pck1 Psmc2 Msgn1 Tcf3 Ctnnb1 Ldb1 Aimp1 Psma7 Dll3 Wnt10b Alx3 Mitf Mapk14 Pabpc1 Tbx5 Akt1 Prkar2a Tfeb Akap5 Prkacb Rbx1 Sema5a Klf5 Slc2a4 Polr2g Cdon Ap2a2 Ap2a1 Atp6v1a Hoxa11 Jag1 Hoxd11 Eya1 Hnf4a Hoxb4 Hoxa6 Lhx1 Gdnf Pax8 Six2 Id4 Frs2 Pik3r1 Dpysl2 Dpysl3 Dpysl5 Tnrc6a Plxnb3 Sema7a Crmp1 Cdh4 Cdh2 Cdh15 Irs2 Ctnna2 Ntn3 Cdkn2a Ppp3cb Rps11 Akt3 Akt2 Lgi2 Adam11 Dct Adam23 Stt3b Cacng3 Ptpn11 Rps25 Rps26 Rps27 Rdx Gab1 Hoxb3 Rps21 Areg Hoxa3 Hoxb1 Srpk1 Hoxb2 Fgf7 Zic1 Myb Tcf7l1 Pou5f1 Myo10 Myo5a Lce3b Lce1m Klk5 Pkp1 Lipk Ppl Klk14 Lipn Zfpm2 Jun Pmel Mamld1 Edil3 Dcc Tfdp2 Unc5c Tfdp1 Slit3 Dock1 Rhoa Dok1 Atp6v1h Epas1 Pabpn1 Zfp36l2 Il12rb2 Cntn6 Eif4b Ank1 Cfl1 Eif4e Dicer1 Trpc6 Myh9 Perp Pdx1 Gck Onecut3 Nkx2-2 Mafa Neurod1 Foxa2 Cnot7 Ptf1a Cnot6 Cnot9 Map2k2 Map2k1 Mapk1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease Kit Pik3r1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis Thrap3 Med31 Pck1 Rbbp7 Ppargc1b Ccnc Zfp423 Cdk8 Med16 Med17 Wnt10b Gatad2a Klf5 Slc2a4 Med8 Ncoa6 Med23 Med24 Tnf Fabp4 Hdac1 Smad4 Med28 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport Kif12 Racgap1 Kif1c Dync1h1 Kif21b Rab1b Dctn2 Kifc5b Kif27 Dynll1 Dync1i2 Dctn1 Sec22b Bicd2 Bicd1 Rint1 Pafah1b2 Use1 Kdelr2 Tmed9 Dynll2 Kif18a Kif2c Klc2 Capza1 Actr1a Actr10 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis Hsd17b14 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis Gng3 Gnb2 Gnb1 Pde10a Pde11a Gnb4 Kcnmb1 Pde1a Kcnmb4 Mapk14 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Pecam1 Ppp2r5a Nos2 P2rx4 Orai2 Stim1 Ptpn11 P2rx7 Ptgir Trpc6 Atp2b2 Atp2b1 Slc8a1 Slc8a2 Apob DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants Alk ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion Gna14 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression Ctnnb1 Akt2 Pmel Dct Stt3b Edil3 Mapk14 Tnrc6a Tcf7l1 Atp6v1a Cdh2 Atp6v1h Rab27a Asah1 Pxdn Bcl2a1d Cdkn2a Dicer1 Myo5a Hdac1 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis Pgm1 Gfpt1 Galm Gne Dhdds BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters Ctnnb1 Tcf7l1 Axin2 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated Ppp2r5e Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence Cdk6 Cdkn2a FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease Flt3 Cbl Zmym2 Ptpn11 Pik3r1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation Ctnnb1 Akt2 Rab27a Pmel Dct Myo5a Mapk14 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT Rhoa Myh10 Myh9 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids Hadha Mecr PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains Ptpn22 Csk Ptprj Cd3g SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed Senp1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 Hdac1 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway Hdac5 Mamld1 Hdac1 Notch3 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome Psmb1 Psmc2 Psma7 Btrc Psmd12 Prkacb Psmd11 Rbx1 Psma6 Psmd8 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants Flt3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation Klb Fgf15 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism Gng3 Pfkfb1 Gnb2 Taldo1 Adra2a Gnb1 Gnb4 Ahcyl1 Ffar1 Acacb Acly Tkt Ppp2r5d Kcnb1 Kcng2 Prkar2a Prkar1a Fasn Akap5 Prkacb Acsl3 Ins2 Prkag2 Gnai2 Adipor2 Kcns3 Rap1a Gna14 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation Nmt1 Akt1 Spr EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors Or4n4 Or4a47 Ldb1 Or51f1d Or1i2 Or2t1 Or10h5 Or51e2 Or51m1 Or8i2 Or5p80 Or4c11 Or14j1 Or8h10 Or2ag1 Or10a4 Or12d17 Or10a5 Or10a2 Or5v1 Or52d1 Lhx2 Or51b6 Or6c76 Or10k2 Or51i2 Or2t44 Or51i1 Or8d1 Or7c70 Or2a7 Or10h1b Or10h28 Or52w1 Or5p6 Or5m10 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels Gng3 Kcnk7 Kcnk6 Gnb2 Gnb1 Gnb4 Kcnmb1 Kcnmb4 Kcnn3 Kcnb1 Kcng2 Kcnj5 Gabbr2 Kcnk9 Kcnab1 Kcns2 Kcnh6 Kcnc1 Kcnab3 Kcng1 Kcnj3 Kcnj10 Kcnn2 Kcnj15 Kcns3 Kcnk4 Kcnq1 Kcnk2 Kcnk10 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters Slc30a3 Slc30a2 Slc39a5 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening H2bu2 H2ax Ubtf H2bc9 H2bc7 H2bc8 H3c7 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer Tgfbr1 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade Igf1 Igf2 Trib3 Akt2 Klb Fgf15 Gab1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Irs2 Ptpn11 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Jag1 Adam17 Hdac5 Ccnc Cdk8 Mib2 Mamld1 Hes5 Psen2 Mib1 Jag2 Rbx1 Hdac1 CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT Ppp3cb BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 Fgf7 Fgf22 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling Abl2 Cap2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency Btd DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors Lpar3 Lpar2 Lpar1 Lpar5 S1pr3 S1pr2 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation Peli1 Ube2v1 Irak1 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs Rad23a Rad23b SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis Tsnax Dicer1 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) Slc7a7 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling Fgf22 Frs2 Ptpn11 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS Adamtsl5 Thsd4 Adamts1 Adamts20 Adamts10 Sema5a Thsd7a Cfp Thbs2 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events Edem2 Magt1 St3gal4 St6galnac3 Mgat4a Mgat4b St3gal1 Stt3b Ano6 St6gal1 Srpk1 Zdhhc3 Tmem258 Ganab Rpn2 Zdhhc9 Rpn1 Golga7 Mgat5 Dad1 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation Drg1 F9 Zc3h15 Etf1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2bu2 H2ax H2bc9 H2bc7 H2bc8 Morc2a Mphosph8 H3c7 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage Uck2 Upp2 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers Psmb1 Rac2 Psmc2 Akt3 Akt2 Psma7 Mlst8 Camk2g Camk2d Camk2b Camk2a Mkrn1 Pml Mapkap1 Akt1 Pip4k2c Prkar2a Prkar1a Prkacb Ptpn11 Hgf Irak1 Gab1 Areg Fgf7 Fgf22 Tsc2 Cbx4 Bmi1 Hdac1 Phc3 Hdac5 Kdm1a Ahcyl1 Pde1a Klb Jun Fgf15 Kit Ier3 Phlpp1 Il33 Pik3r5 Strn Flt3 Egr1 Ppp2r5e Akt1s1 Rnf146 Ppp2r5d Snai1 Ppp2r5c Frk Camkk2 Ppp2r5b Ppp2r5a Ins2 Camk4 Rbbp7 Myd88 Trib3 Pik3cg Lamtor2 Gatad2a Irs1 Ezh2 Frs2 Usp7 Pik3r1 Bdnf Tnrc6a Csnk2b Irs2 Mapk1 Psmd12 Mdm2 Psmd11 Egfr Psma6 Psmd8 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death Ripk1 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin Egfr INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors H2bu2 Pck1 Rbbp7 Gatad2a H3c7 Zmynd8 Tcf19 H2ax Ikzf1 G6pc1 H2bc9 H2bc7 H2bc8 Hdac1 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion Ngrn PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase Kcnq1 Kcne5 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane Nkiras2 Peli1 Myd88 Usp14 Jun Irak1 Traf2 Mapk14 Map3k8 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ecsit Ripk2 Nkiras1 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat Ell Polr2k Ercc3 Polr2g Ssrp1 Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes Rac2 Cyba Cybb Nos2 Atp6v1a Atp6v0d2 Atp6v1h Atp6v1f Atp6v0a4 Tcirg1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis Ripk1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants Fga Csk Fgg Camk2g Camk2d Camk2b Camk2a Arrb1 Map3k11 Apbb1ip Rap1a Phb1 Map2k2 Map2k1 Mapk1 Fgb LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes Pcbp4 Zfp385a GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation Gng3 Gnb2 Gnb1 Gnb4 Prkar2a Prkar1a Prkacb SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants Mapk1 Dusp10 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT Psmb1 Fzd6 Rac2 Psmc2 Pde6a Pde6b Ctnnb1 Prickle1 Akt2 Psma7 Wnt10b Kremen1 Camk2a Akt1 Btrc Rbx1 Wnt8a Trrap Wnt7a Ruvbl1 Tcf7l1 H2ax Hdac1 Vangl2 H2bu2 Men1 Gng3 Gnb2 Gnb1 Gnb4 Axin2 Ap2a2 Ap2a1 Ppp2r5e Vps26a Frat2 Rnf146 Znrf3 Daam1 Ppp2r5d Rspo1 Ppp2r5c Dact1 Ppp2r5b Rhoa Ppp2r5a Tmed5 Lgr5 Lgr6 Dkk1 H2bc9 H2bc7 H2bc8 Prkcb Ctbp1 H3c7 Tnrc6a Csnk2b Zranb1 Wnt5a Psmd12 Wnt5b Ppp3cb Psmd11 Gnat2 Psma6 Fzd4 Psmd8 Fzd7 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol Ip6k3 Itpk1 Nudt11 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling Il33 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC Casp3 Dcc G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events Gng3 Htr6 Gnb2 Taar5 Gnb1 Ramp2 Pde10a Sct Pde11a Gnb4 Pde7b Pde1a Rxfp1 Grk6 Fshr Gpr83 Tshr Gper1 Ramp1 Prkar2a Prkar1a Ptger2 Gnaz Prkacb Gpr20 Gipr Ptgir Glp2r Ramp3 Gnai2 Pde3b Arrb1 Drd5 Ppan Gip SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis Sphk1 Cers6 Mfsd2b Cers3 Cers2 Cers1 Ormdl1 Sgms2 Kdsr REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 Trex1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades Fga Myd88 Fgg Unc93b1 S100a9 S100a1 Btk Tlr4 Fgb Tlr7 Ly96 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Csnk2b Cdk5 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription Smad4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction Crk Ptpn11 Pik3r1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling Ctnnb1 Tcf7l1 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis Pck1 Gpi Eno2 G6pc1 Pcx Slc37a4 EG433182 Fbp2 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins Ganab St3gal4 St6galnac3 St3gal1 St6gal1 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle Kctd13 Ktn1 Ankrd26 Txnl1 Pkp4 Lemd3 Tnfaip1 Ckap4 Frs2 Prag1 Pik3r1 Fnbp1 Plxnd1 Ptpn13 Nudc Golga3 Aldh3a2 Vangl2 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol Inpp1 Synj1 Miox Inpp4a Inpp5b Mtmr7 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation Exo1 Ssrp1 Taf7 Rfc5 Rfc3 Taf5 Rfc4 Taf2 Rfc2 Dyrk2 Wrn Mapk14 Rpa2 Rbbp8 Rpa3 Hipk1 Prkag2 Cdk5 Trp53rkb Rad9a Bard1 Csnk2b Prkag3 Taf11 Taf13 Taf12 Mdm2 Pin1 Ccna1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols Cyp7a1 Arnt2 Arnt Cyp39a1 Cyp11b1 Cyp11b2 Cyp7b1 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 Tfdp1 Mybl2 Ccne1 Pcna Hdac1 Ccna1 Tfdp2 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins Rhoa REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription H2bu2 Ctbp1 Rbbp7 Tcf3 Strap Kdm1a Zmym2 Mphosph8 Ezh2 H3c7 Mcrip1 Snai1 Pkm Klf9 Zbtb33 H2ax Twist2 Foxp2 Foxa2 H2bc9 H2bc7 Mapk1 H2bc8 Hdac1 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Jak1 Strap Zmym2 Tyk2 Ilf3 Hoxc8 Ganab Rpn2 Rpn1 Pals1 Tmem258 Nectin2 H2ax Eps15 Hdac1 H2bu2 Pcsk7 Kdm1a Nectin1 Cdh8 Nectin4 Cdh6 Birc2 Cdh3 Cldn23 Cdh19 Mphosph8 Cdh13 Cdh12 Cadm2 Mcrip1 Pkm Cdh24 Snai1 Dock1 Cldn2 Klf9 Zbtb33 Zc3h12a Twist2 Foxp2 Sdk1 H2bc9 H2bc7 Ang Cldn1 H2bc8 Ctbp1 Rbbp7 Ezh2 H3c7 Cdh11 Tnrc6a Csnk2b Cdh4 Cdh2 Foxa2 Cdh15 Mapk1 Psmd12 Mdm2 Psmd11 Banp Psma6 Dad1 Psmd8 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer Tgfbr1 Smad4 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria Asl NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription Gzmb Mamld1 Hes5 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function Exo1 Bard1 Rbbp8 Palb2 Wrn MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation Fga Arrb1 Csk Fgg Apbb1ip Rap1a Map2k2 Map2k1 Mapk1 Lamtor2 Fgb GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis Fcsk SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 Klb Fgf15 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases Spock3 Cma1 Mmp10 Mmp7 Mmp17 Col18a1 Ctsg Prss2 Mmp9 Klkb1 Mmp1a Plg AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions Maoa CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Ube2c Fzr1 Anapc11 Anapc10 Anapc1 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing Ins2 Ero1b Cpe Rab27a Myo5a Cltrn Exoc7 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) Slc22a18 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family Slc30a3 Slc30a2 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation Tnrc6a TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Arl2bp Slc29a3 Slc28a2 Slc29a4 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin Irs2 Irs1 Ptpn11 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Cbl Cdc37 Gab1 Egfr Pik3r1 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity Rhoa DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine Slc25a10 Ethe1 Gadl1 Mpst Cdo1 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response Nup133 Dnajc7 Dnajc2 Hspa12b Bag3 Bag2 Hspa14 Hspa4l Hspa9 Ccar2 Rpa2 Nup205 Nup107 Sec13 Rpa3 Mapk1 Nup85 Nup88 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways Smad4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane Pik3r4 Mtmr7 Mtm1 Mtmr4 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK Mapk1 Gast Egfr CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism Pfkfb2 Pck1 Pfkfb1 Nup133 Eno2 Pcx Fbp2 Pfkp Ppp2r5d Gck Nup205 Gpi Nup107 Sec13 G6pc1 Slc37a4 EG433182 Prkacb Nup85 Pfkfb4 Nup88 Pfkfb3 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy Tufm Vps11 Vps33a Vps33b Vps16 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates Ltc4s CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization Pck1 Tcf3 Myog Ctnnb1 Meaf6 Myod1 Ctr9 Pwwp2a Zmynd8 Tcf19 Ikzf1 Pwwp2b Adnp G6pc1 Vps72 Suv39h2 Padi4 Kdm4d Brms1 Kdm4b Fam124b Pbrm1 Prmt7 Chd6 Trrap Igf2 Arid5b Supt3 Kdm1b Kmt5b Kdm5c Kdm5b Msl1 Padi6 Ruvbl2 Ruvbl1 Kdm2a Setd3 Usp22 Setd7 Brd8 Elp1 Tada1 H2ax Kdm3b Elp6 Sap30l Kdm3a Nqo1 Taf12 Hmg20b Phf20 Hdac1 H2bu2 Sap30 Ssrp1 Yeats2 Aebp2 Kdm1a Hcfc1 Axin2 Kansl2 Phf5a Setd1b Sap130 H2bc9 H2bc7 H2bc8 Snrpa1 Tada2a Bcl11a Rbbp7 Phf10 Sf3b6 Snrpn Gatad2a Cherp Ezh2 H3c7 Puf60 Ing5 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling Apoc2 Apoc3 Apoa1 Apoe AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 Castor1 Szt2 Lamtor2 Mlst8 Tcirg1 Atp6v1a Sec13 Samtor Atp6v0d2 Sh3bp4 Atp6v1h Nprl2 Atp6v1f Wdr59 Depdc5 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription Polr3d Polr2k Polr3f Polr3k Snapc1 Snapc2 Gtf3c2 Gtf3a Brf2 Polr3a Ssb RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling Rap1a Prkacb Sipa1 Rap1gap2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system Psmb1 Psmc2 Fancc Psma7 Camk2g Camk2d Mapk14 Mt2 Camk2b Npm1 Plcg2 Camk2a Pml Tnfsf13 Akt1 Rbx1 Maoa Il21r Muc1 Gbp7 Eif3l Eif3e Nup205 Nup107 Eif3b Ifnlr1 Eif3c Il18r1 Sec13 Ifit3b Trim8 Crlf2 Nup85 Nup88 Ilf2 Nup133 Il2rb Ptpn2 Il1r2 Ifi35 Uba7 Rigi Il20ra Il33 Egr1 Ppp2r5d Tollip Ppp2r5a Il15 Il19 Osmr Rnasel Il10rb Itgam Irf5 Nkiras1 Nkiras2 Flna Il25 Rag2 Peli1 Rag1 Myd88 Usp14 Isg20 Il13ra1 Ebi3 Trim62 Irf6 Crlf1 Il7r Abl2 Irf9 Trim38 Irs1 Kpna4 Hspa9 Trim31 Ca1 Pik3r1 Tec Ip6k2 Ptpn20 Csf2ra Irs2 Prlr Il1r1 Rps11 Tbk1 Akt3 Akt2 Fancb Jak1 Tyk2 Ccl22 Ccl20 Ifna16 Ilf3 Btrc Ptpn13 Ube2v1 Nod1 Ctsg Ripk2 Ptpn11 Adam17 Csk Rps25 Casp1 Rps26 Trim21 Oas2 Rps27 Adar Blnk Casp3 Eif4g3 Hgf Irak1 Il17f Rps21 Mmp9 Gbp2 Il17a Mmp1a Tab2 H2-Q10 Il13 Tnfsf13b Tnf Capza1 Batf Il21 Taldo1 Sphk1 Gsdmd Tnfrsf1a Sh2b3 Birc3 Jun Birc2 Map3k8 Flt3 Mef2c Hsp90b1 Eif2s3x Eif2s2 Cbl Map3k14 Tnfsf15 Tnfrsf9 Nos2 Lta Eda2r Il12rb1 Crk Tnfrsf13b Il12rb2 Cfl1 Eif4e Il12b Pdcd4 Il12a Snrpa1 Sod2 Hnrnpa2b1 Ptpn7 Il34 Traf2 Ptprj H3c7 Lifr Prtn3 Csf2 Map2k1 Mapk1 Il2 Psmd12 Pin1 Psmd11 Psma6 Psmd8 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation Mgst1 Ggt1 Gstt1 Chac1 Oplah Gstk1 Mgst3 Gsta5 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation Pik3cg Icosl Pik3r5 Pik3r1 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors Chrm5 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development Rpl4 Psmb1 Psmc2 Ldb1 Rpl39 Psma7 Cacna1h Rpl7 Itgav Psen2 Pabpc1 Rpl22 Ranbp9 Prkar2a Akap5 Prkacb Rbx1 Hoxa2 Slit1 Msi1 Sema5a Col4a5 Lhx2 Etf1 Upf3a Gspt1 Col4a4 Col6a3 Adgrg6 Mbp Pmp22 Ap2a2 Srgap1 Ap2a1 Srgap2 Rpl18 Plxna1 Actr2 Actr3 Myh10 Gdnf Abl2 Frs2 Ptk2 Pik3r1 Dpysl2 Dpysl3 Plxnd1 Dpysl5 Plxnb3 Prnp Csnk2b Cacna1i Sema7a Crmp1 Arpc4 Sh3kbp1 Irs2 Ppp3cb Dscaml1 Egfr L1cam Arhgef11 Rps11 Reln Dok6 Scn8a Sptbn4 Sptb Rgmb Git1 Rgma Shtn1 Epha5 Scn11a Ephb1 Ephb3 Ephb4 Cap2 Sptan1 Ablim3 Lama2 Evl Ptpn11 Rps25 Rps26 Rps27 Rdx Gab1 Rps21 Mmp9 Myo10 Dcc Unc5c Slit3 Dock1 Rhoa Dok1 Cntn6 Cfl1 Ank1 Trpc6 Cdk5 Myh9 Map2k2 Map2k1 Mapk1 Psmd12 Epha4 Psmd11 Psma6 Psmd8 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes Ca2 Cyb5r2 Cyb5r1 Ca1 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system Rdh12 Opn1sw INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling Isg20 Jak1 Oas2 Adar Tyk2 Irf6 Irf9 Ifi35 Gbp2 Ifna16 Egr1 Ip6k2 H2-Q10 Ifit3b Rnasel Irf5 Ptpn11 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication H2bu2 H2ax Orc1 Orc2 H2bc9 H2bc7 H2bc8 H3c7 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids Mecr Acer3 Stard5 Hacd1 Acacb Stard3 Arsj Arsi Med8 Cyp39a1 Decr2 Esrra Pip4k2c Acot12 Prkacb Cbr1 Plekha6 Lgmn Hao2 Ugt8 Pik3c2b Gdpd5 Cyp4f40 Gdpd1 Mtmr7 Ctsa Mtmr6 Fads2 Mtmr4 Ppt1 Fads1 Mfsd2b Slc27a1 Asah1 Ppp1cc Sgms2 Fabp3 Akr1b1 Fabp5 Cyp7b1 Fabp6 Med28 Tecr Ptgr2 Arnt2 Phyh Amacr Acot3 Aacs Hexb Acot9 Mtf1 Slc25a17 Pik3r5 St6galnac5 Ggt1 Cyp7a1 Smpd1 Cyp11b1 Ormdl1 Cyp11b2 Dpep1 Hsd11b1 Vdr Hadha Acaa2 Gpcpd1 Ptpmt1 Ptdss2 Pik3cg Slc44a2 Mogat1 Pitpnb Cpne1 Prkag2 Pnpla3 Cpne3 Pi4k2b Lpcat4 Pla1a Phospho1 Pgs1 Abhd3 Acbd6 Mcee Cpne6 Hacl1 Pik3r1 Plaat3 Pla2g3 Mgll Csnk2b Cyp2d22 Gpat4 Cyp2c65 Etnk1 Chpt1 Hsd17b14 Gpat2 Lpin1 Sc5d Stard10 Dgat2 Abhd5 Mboat7 Fitm1 Chkb Crls1 A4galt Crat Txnrd1 Tnfaip8l1 Inpp5f Mtm1 Pon3 Acly Elovl1 Pon1 Pon2 Elovl6 Pik3r4 Synj1 Abcd3 M6pr Ptpn13 Ltc4s Me1 Hmgcl Slc27a5 Sgpp2 Thrap3 Fhl2 Cers6 Cers3 Cers2 Cers1 Ggps1 Lbr Inpp4a Med23 Slco1b2 Med24 Plin2 Psap Morc2a Kdsr Scd1 Arnt Ccnc Sphk1 Mbtps1 Med16 Med17 B4galnt1 Elovl5 Ncoa6 Rab14 Cidec Stard3nl Cpt1a Fasn Fabp4 Acsl3 Med31 Trib3 Ppargc1b Ptgds Cdk8 Slc10a2 Cerk Apoa1 Apoa2 Hsd17b4 Dhrs7b Neu3 B4galt6 Neu1 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions Slc44a2 Slc10a6 Slc22a12 Slco4c1 Slc25a10 Slco1b2 Emb Slco4a1 Slco2b1 Slco1c1 Slc16a2 Slc16a3 Slc13a5 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs Flt3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD Psmb1 Psmc2 Psma7 Syvn1 Psmd12 Psmd11 Psma6 Psmd8 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis Rfc1 Pold4 Rfc5 Rfc3 Pola2 Rfc4 Rfc2 Pcna MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport Akap1 Vdac3 Phb1 Pmpcb Vdac1 Slc8b1 Spg7 Phb2 Micu1 Mcu Parl NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway Hnf4a Esrra Esrrb Nrbp1 Ar Vdr Rara PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes Men1 Yeats2 Setd1b Ncoa6 Hcfc1 Akap8l Phf20 Psip1 Kansl2 Bod1 Cxxc1 Tada2a DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis Cspg5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway Polb EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation Nuf2 Nup133 Dync1h1 Dynll1 Dync1i2 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cenpa Nsl1 B9d2 Nek9 Nek6 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Nudc Kif2c Ppp1cc Nup85 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly Apoc2 Apoc3 Mttp Apoa1 Apoa2 Apoe Apob Apoa4 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs Bard1 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis Tfdp1 Tnrc6a Myb Gmnn Gmnc Mcidas Ccno BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism Cyp7a1 Hsd17b4 Abcd3 Cyp39a1 Amacr Slc10a2 Slco1b2 Stard5 Slc27a5 Fabp6 Cyp7b1 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Jak1 Strap Zmym2 Tyk2 Ilf3 Hoxc8 Ganab Rpn2 Rpn1 Tmem258 Nectin2 H2ax Eps15 Hdac1 H2bu2 Pcsk7 Kdm1a Nectin1 Cdh8 Nectin4 Cdh6 Birc2 Cdh3 Cdh19 Mphosph8 Cdh13 Cdh12 Cadm2 Mcrip1 Pkm Cdh24 Snai1 Dock1 Klf9 Zbtb33 Zc3h12a Twist2 Foxp2 H2bc9 H2bc7 Ang H2bc8 Ctbp1 Rbbp7 Ezh2 H3c7 Cdh11 Tnrc6a Csnk2b Cdh4 Cdh2 Foxa2 Cdh15 Mapk1 Psmd12 Mdm2 Psmd11 Banp Psma6 Dad1 Psmd8 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis Ppcs AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Psmb1 Psmc2 Prkag3 Erlin2 Psma7 Erlin1 Prkag2 Psmd12 Psmd11 Psma6 Psmd8 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex Psmb1 Psmc2 Ctbp1 Ctnnb1 Psma7 Ppp2r5e Frat2 Ppp2r5d Zranb1 Ppp2r5c Ppp2r5b Tcf7l1 Ppp2r5a Btrc Psmd12 Rbx1 Psmd11 Hdac1 Psma6 Psmd8 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) Atrx SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT Kit G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events Gng3 Gnb2 Adra2a Prkch Gnb1 Gnb4 Rgs17 Gnaz Gnai2 Prkcb CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) Sc5d LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors Ltb4r2 Cysltr1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol Plcg2 Itpk1 Plcb4 Synj1 Itpkb Plcd1 Plcz1 Inpp5b Plch2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity Cbl Sh3kbp1 Ptpn2 Stam2 Hgf Eps15 Ptprj ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation Adh4 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions Dscaml1 Dcc RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking Gopc VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins Gng3 Gnb2 Myo5b Gnb1 Gnb4 Prkar2a Prkar1a Prkacb Rab11a ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins Art1 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination H2bu2 H2ax H2bc9 H2bc7 Terf2 H2bc8 Terf2ip TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway Tbk1 Rigi RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants Nf1 Spred1 Spred3 Spred2 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation Tasl Irf5 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) Irs1 Pik3r1 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin Plcg2 Pik3cg Irs2 Gab1 Pik3r5 Pik3r1 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII Cbl Cdc37 Gab1 Egfr Pik3r1 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network Rab43 Vps52 Naa38 Naa30 Arfip2 M6pr Rhobtb3 Rab9 Cog2 Cog6 Cog8 Gcc2 Cog1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling Strap Tgfbr1 Ppp1cc Ppp1r15a Usp15 Mtmr4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) Gaa Agl Pgm1 Pygl Pygm Pygb REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation Tnrc6a SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose Gmppa DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity Cdk6 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins Enpep Cma1 Cpb1 Cpa3 Ctsg Ace Anpep Cpb2 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development Maf Rbm14 Satb2 Mapk1 Ucma Ar Smad4 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells Pdx1 Onecut3 Ptf1a TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses Git1 Gls Cacng3 Camk2g Camk2d Camk2b Glul Tomt Camk2a Prkar2a Prkar1a Akap5 Prkacb Maoa Gnai2 Chrnb2 Gls2 Ppfia2 Ppfia4 Gng3 Cplx1 Gnb2 Gnb1 Slc18a3 Gnb4 Comt Ap2a1 Camkk2 Prkcb Kcnj5 Gabra4 Glrb Gabbr2 Camk4 Lin7c Grin3b Chrnd Lrrc7 Gabrr1 Glra3 Prkag2 Gabrr3 Gabrr2 Nrgn Kcnj3 Myo6 Kcnj10 Grik5 Gabrb3 Grik4 Kcnj15 Rasgrf2 Chrna9 Aldh5a1 Prkag3 Cacna2d1 Cacna1b Mapk1 Mdm2 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation Csnk2b Ppp1cc SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste Otop1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein Gck Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis Sod2 Mterf1b Camk4 Ppargc1b Hcfc1 Idh2 Mef2c Ncoa6 Polg2 Crtc3 Twnk Esrra Crtc1 Tfb2m RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape Ercc3 Taf7 Taf5 Taf2 Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 Shtn1 Rdx Mapk1 Ap2a2 L1cam Dpysl2 Ap2a1 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport Ins2 Sptbn4 Sptb Dync1h1 Rab1b Dctn2 Kdelr2 Sptan1 Tmed9 Dynll1 Dynll2 Dync1i2 Golga2 Gorasp1 Dctn1 Cog2 Cog6 Bet1l Ank1 Cog8 Capza1 Actr1a Actr10 Cog1 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade Fga F10 F11 Fgg F2 F9 Ano6 Fgb KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization Pkp1 Krt20 Krt18 Lipk Krt16 Ppl Krt15 Klk14 Lipn Pkp4 Krt76 Krtap1-3 Krt85 Krtap2-4 Perp Krt4 Krt2 Krt8 Dsp Lce3b Krtap12-1 Krt9 Lce1m Klk5 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds Adh4 Cyp2s1 Arnt2 Mtarc1 Arnt Fmo2 Por Cyp4f40 Ephx1 Cyp7a1 Cyp4f14 Cyp2d22 Cyp39a1 Cyp2c65 Cyp11b1 Cyp11b2 Ces2h Cyp7b1 Maoa SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants Fga Csk Fgg Camk2g Camk2d Camk2b Camk2a Arrb1 Apbb1ip Rap1a Map2k2 Map2k1 Mapk1 Fgb G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma Gng3 Gnb2 Akt3 Pik3cg Akt2 Gnb1 Rhoa Gnb4 Akt1 Pik3r5 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation Ell Polr2k Ercc3 Polr2g Ssrp1 Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators C1qc Crp C1qa Colec10 C1qb C1rb DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER Sec22b Preb Lman2 Areg MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation Mrps16 Tufm Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mrpl47 ATP6 Mrpl49 Mrps23 Mrps28 Mrpl52 Mrpl33 Mtrf1l mt-Cytb Tsfm mt-Nd4l mt-Nd4 Mrpl11 mt-Nd5 Mrpl34 mt-Nd6 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome Camk4 Hdac1 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere Atrx SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) Jak1 Tyk2 Ptpn11 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate Idh1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids Amacr Mbtps1 Stard5 Stard3 Acacb Mtf1 Elovl6 Cyp7a1 Cyp39a1 Abcd3 Ncoa6 Stard3nl Cyp11b1 Slc27a5 Cyp11b2 Fasn Hsd11b1 Vdr Lgmn Slc10a2 Ggps1 Lbr Hsd17b4 Hsd17b14 Slco1b2 Sc5d Akr1b1 Cyp7b1 Fabp6 Scd1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins Psmb1 Psmc2 Psma7 Ube2c Btrc Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 Gng3 Gnb2 Gnb1 Gnb4 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism Gls2 Pycr3 Pycr2 Gls Glul METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines Slc19a1 Mthfd1 Folr2 Aldh1l1 Slc46a1 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism Ada DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS Slc35b3 Slc26a2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp2c65 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins Nuf2 Nup133 Dync1h1 Diaph3 Dynll1 Srgap2 Dync1i2 Ppp2r5e Ppp2r5d Daam1 Ppp2r5c Evl Ppp2r5b Rhoa Ppp2r5a Scai Cenpa Nsl1 B9d2 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Nudc Kif2c Ppp1cc Rhod Nup85 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes Tuba1a Cdk5rap2 Cep250 Sdccag8 Dync1h1 Cep78 Pcm1 Dctn2 Cep164 Ssna1 Cpap Tubg1 Dynll1 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Haus5 Csnk1d Cdk11b Tubgcp5 Tubgcp4 Nedd1 Actr1a TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Ercc3 Rfc1 Pold4 Cops8 Rfc5 Xab2 Cops7a Rfc3 Cops7b Rfc4 Rfc2 Pcna Usp7 Ell Polr2k Polr2g Rpa2 Isy1 Gtf2h2 Rpa3 Gtf2h3 Gtf2h5 Rbx1 Ddb1 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport Gpc3 Gpc2 Gpc4 Clps Retsat Apoa1 Apoa2 Apoe Apoa4 Apoc2 Sdc3 Apoc3 Apob DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations Fkrp Slc35a4 Slc35a1 Crppa Large2 Fktn Pomk RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle Noxa1 Racgap1 Emd Git1 Arhgap15 Lemd3 Diaph3 Arhgap17 Srgap2 Cdc42ep1 Rab7 Nckap1l Erbin Baiap2l1 Bcr Ophn1 Slitrk5 Slitrk3 Jag1 Nhs Arap2 Mcam Prex1 Wasf2 Abl2 Pik3r1 Abi2 Lbr Cyba Cybb Nox3 Arhgap42 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL Csnk2b DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis Sod2 C1qbp Golga2 Cdk5 Jun TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Map3k14 Lta Birc3 Tnfsf13b Birc2 Traf2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Atrx TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production Nsmaf Tnfrsf1a Tnf ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway Tab2 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Jak1 Strap Zmym2 Tyk2 Ilf3 Hoxc8 Actn1 Ganab Rpn2 Rpn1 Col17a1 Pals1 Tmem258 Nectin2 H2ax Eps15 Itgb4 Hdac1 Plec H2bu2 Pcsk7 Ilk Kdm1a Parva Nectin1 Cdh8 Nectin4 Cdh6 Birc2 Cdh3 Cldn23 Cdh19 Mphosph8 Cdh13 Cdh12 Cadm2 Mcrip1 Pkm Cdh24 Snai1 Dock1 Cldn2 Klf9 Zbtb33 Zc3h12a Twist2 Foxp2 Tesk1 Sdk1 Fblim1 Parvb H2bc9 H2bc7 Ang Cldn1 H2bc8 Flna Ctbp1 Rbbp7 Ezh2 H3c7 Cdh11 Tnrc6a Csnk2b Cdh4 Cdh2 Foxa2 Cdh15 Mapk1 Psmd12 Mdm2 Psmd11 Banp Psma6 Dad1 Psmd8 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters Slc26a2 Slc26a9 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission Camk4 Camk2a Lrrc7 Camk2g Camk2d Camk2b DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA Aldh5a1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling Jak1 Tnfrsf1a Tyk2 Il1r2 Ccl22 Csf2 Ccl20 Il10rb Il12b Il1r1 Tnf Il12a DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer Jag1 Adam17 Hdac5 Ccnc Cdk8 Mib2 Mamld1 Hes5 Psen2 Mib1 Jag2 Rbx1 Hdac1 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism Xdh Gda Entpd4 Upp2 Entpd8 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways Gng3 Noxa1 Gnb2 Gnb1 Gsdmd Gnb4 Ahcyl1 Jun Mapk14 Ggt1 Plcg2 Dock1 C3ar1 Nckap1l P2rx4 Prkar2a Wipf3 Crk Prkar1a Gnaz Actr2 Ctsg Cysltr1 Prkacb Actr3 Was Dpep1 Cd3g Btk Adam17 P2rx7 Pycard Sugt1 Casp1 Myh9 Wasf3 Wasf2 Gnai2 Ptk2 Abi2 Cyba Arpc4 Wnt5a Mapk1 Myo10 Myo5a Fzd7 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) Sod2 Akt1 Lonp1 Hspa9 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK Rpa2 Rfc1 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna Mad2l2 Rev1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis Lbr Sc5d Ggps1 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import Fis1 Abcd3 Pex12 Slc25a17 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions Ank1 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division Mau2 Wapl Stag2 Smc3 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Txnrd1 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) Rit2 Cdk5 Id4 Irs1 Mapk14 Frs2 Ap2a2 Ap2a1 Pik3r1 Egr1 Mef2c Ppp2r5d Rhoa Trib1 Rap1a Irs2 Map2k2 Crk Map2k1 Tph1 Mapk1 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling H2bu2 Psmb1 Psmc2 Ctnnb1 Erlin2 Psma7 Jak1 Erlin1 Jun Mib2 Stt3b Rpn2 Pdcd1lg2 Rpn1 Btrc Epas1 Tead4 H2bc9 H2bc7 H2bc8 Cd3g Rbx1 Ptpn11 Magt1 Rbbp7 Csk Brd4 Prkag2 Tead3 Tead2 Ezh2 H3c7 Tnrc6a Tmem258 Csnk2b Prkag3 Tcf7l1 H2ax Psmd12 Psmd11 Psma6 Dad1 Psmd8 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body Lmbrd1 Cd320 Tcn2 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation Xrcc4 Psip1 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade Gpc3 F10 Gpc2 F12 F11 Gpc4 F2 F9 Serpine2 Ano6 Smpd1 Prtn3 Sdc3 Klkb1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules Rtn3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes Ilf2 Nup133 Fancb Fancc Jak1 Sphk1 Ptpn2 Uba7 Rigi Ilf3 Npm1 Eif2s3x Eif2s2 Ppp2r5a Rnasel Eif4e Flna Rps25 Casp1 Rps26 Oas2 Rps27 Adar Eif4g3 Gbp2 Rps21 Kpna4 Eif3l Eif3e Nup205 Eif3b Nup107 Eif3c Sec13 Ifit3b Pin1 Nup85 Rps11 Nup88 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Psmb1 Hif3a Psmc2 Psma7 Limd1 Ajuba Epas1 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation Mllt3 Ercc3 Ssrp1 Ctr9 Ell Polr2k Polr2g Gtf2h2 Gtf2h3 Aff4 Gtf2h5 Supt6 Gtf2f1 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation Prkar2a Prkar1a Prkacb POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events Camk4 Lrrc7 Git1 Prkag2 Nrgn Camk2g Camk2d Camk2b Rasgrf2 Camk2a Prkag3 Camkk2 Prkar2a Prkar1a Mapk1 Prkacb G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint H2bu2 Exo1 Rfc5 Rfc3 Rfc4 Rfc2 Wrn Rpa2 Rad9a Bard1 Rbbp8 H2ax Rpa3 H2bc9 H2bc7 H2bc8 Herc2 Ccna1 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway Enoph1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis H2-Q10 Atp6v1h Ap1s3 Ap2a2 Ap2a1 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks H2bu2 Kdm4b Eya1 Bard1 H2ax Eya3 H2bc9 Apbb1 H2bc7 H2bc8 Herc2 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) Opn1sw FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm Lhx1 Pax8 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy Csnk2b Tbk1 Tomm6 Vdac3 Tomm7 Atg5 Ube2v1 Vdac1 Ube2l3 Mfn1 Mfn2 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling Htr6 Taar5 Ramp2 Sct Pde7b Apln Rgs8 Galr1 Camk2g Rxfp1 Camk2d Pnoc Camk2b Grk6 Tas2r131 Camk2a Gpr83 Tas2r135 Opn3 Gper1 Gpsm3 Akt1 Gpsm1 Npbwr1 Ramp1 Prkar2a Ppp1r1b Prkar1a Ptger2 Ptger3 Prkacb Prokr1 Grm8 Rgs2 Gpr20 Dgkb Gipr Lpar4 Ptgir Lpar3 Lpar2 Lpar1 Rgs22 Prkch Glp2r F2 Dagla S1pr3 Xcl1 Grp S1pr2 Ffar3 Gpr37l1 Bdkrb2 Bdkrb1 Cort Rgs17 Ramp3 Chrm5 Gnai2 P2ry13 P2ry2 Gpr55 P2ry1 Tac3 Gprc6a Opn4 Nmb Dgkk Plcb4 Lpar5 Cck Ppan Prok1 Dgkz Nms Ltb4r2 Gast F2rl2 Gip Adra2a Pik3r5 Ppp2r5d Avpr1b Gnaz Cysltr1 Prkcb Btk Opn1sw Pik3cg Pik3r1 Rasgrf2 Mgll Arrb1 Ppp3cb Arhgef15 Egfr Arhgef17 Gnat2 Arhgef11 Akt3 Akt2 Ffar1 Ccl20 Ccl2 Cxcl5 Fshr Tshr Prex1 Tas2r39 Tas2r38 Pde3b Drd4 Drd5 Tas1r1 Tas1r3 Psap Gna14 Tas2r16 Tas2r13 Gng3 Gnb2 Tas2r137 Tas2r136 Gnb1 Pde10a Tas2r140 Gnb4 Pde11a Ahcyl1 Pde1a Tas2r119 Tas2r4 Tas2r7 Tas2r120 Camkk2 C3ar1 Rhoa Tas2r107 Tas2r40 Tas2r41 Gabbr2 Camk4 Trpc6 Cdk5 Npy Mapk1 Mchr1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis Lalba REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation Slc35d2 Ugt2a1 Ugt2a2 Abhd10 Ugt1a2 Ugt2b1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation Hdac5 Psmb1 Psmc2 Akt3 Akt2 Psma7 Kdm1a Jun Mlst8 Egr1 Rnf146 Mkrn1 Snai1 Frk Pml Akt1 Rbbp7 Lamtor2 Gatad2a Ezh2 Usp7 Tnrc6a Csnk2b Cbx4 Mapk1 Bmi1 Psmd12 Psmd11 Hdac1 Phc3 Psma6 Psmd8 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation Lamp2 Tgfb2 Wdr1 Ola1 Nhlrc2 Calu Endod1 Lefty2 Sytl4 Clec3b Manf Actn1 Lgals3bp Apoh Pecam1 Cyb5r1 Orm3 Cfl1 Selp Plg Fgb Cd63 Fga Igf1 Flna Igf2 Fgg Hgf Cd9 Apoa1 Cfd Ttn Psap DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production Dhx36 Myd88 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus Xrcc4 Psip1 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK Irs1 Pik3r1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy Lamp2 Plin2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated Ppp2r5e Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels Kcnmb1 Kcnmb4 Kcnn3 Kcnn2 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K Irs1 Pik3r1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling Il13ra1 Jak1 Tyk2 Muc1 Hgf Ccl22 Il17f Mmp9 Il17a Mmp1a Pik3r1 Hsp90b1 Nos2 Akt1 Il13 Il12b Tnf Itgam Il12a Batf Maoa DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions Flna Actn1 Tesk1 Ilk Parva Fblim1 Parvb ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases Atp4b Atp11b Atp13a1 Atp8b3 Atp12a Atp1a1 Atp9b Camk2g Camk2d Camk2b Pdzd11 Camk2a Atp1b1 Atp2b2 Atp1b3 Atp2b1 Atp8a1 Atp4a REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors Akt3 Akt2 Akt1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA Tbk1 Trex1 Nlrp4e Trim21 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor Gng3 Gnb2 Gnb1 Gnb4 Gna14 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Ptk6 Cbl Dok1 Akt1 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR Kdr DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification Ngrn Lrpprc ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis Ogdh HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones Kdm4b Arid5b Kdm1a Kdm3b Kdm1b Kdm3a Kdm5c Kdm5b Kdm4d Kdm2a H3c7 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade Jun Mapk14 Map3k8 Tlr7 Mef2c Pik3r4 Ppp2r5d Btrc Ube2v1 Nod1 Tasl Ripk2 Irf5 Nkiras1 Nkiras2 Peli1 Myd88 Usp14 Irak1 Traf2 Tlr4 Ly96 Tab2 Rbsn Map2k1 Mapk1 Ecsit GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors Gng3 Gnb2 Glp2r Gnb1 Sct Gnb4 Gip Gipr INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Ube2c Anapc11 Anapc10 Anapc1 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis Psmb1 Pkp1 Psmc2 Ctnnb1 Akt3 Akt2 Psma7 Gsdmd Nmt1 H1f2 H1f3 Birc2 Dynll1 Clspn Sptan1 Dcc Tfdp2 Tfdp1 C1qbp Akt1 Gzmb Casp3 Tnfrsf10b Fas Traf2 Dynll2 Ripk1 Tlr4 Ptk2 Ly96 Gsdme Satb1 Mapk1 Psmd12 Psmd11 Dsp H1-5 Psma6 Plec Psmd8 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Sod2 Ins2 Pck1 Agrp Gck G6pc1 Npy Nr3c1 Hdac1 Smad4 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development Jag1 Hnf4a Lhx1 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria Tfdp1 Tfdp2 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas Fgf7 Lama2 Lamb2 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Jag1 Adam17 Hdac5 Ccnc Cdk8 Mib2 Mamld1 Hes5 Psen2 Mib1 Jag2 Rbx1 Hdac1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle Ppfia2 Ppfia4 Cplx1 Slc18a3 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid Rdh16f2 Adh4 Crabp1 Dhrs9 Rdh14 Sdr16c5 Fabp5 Rara WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis Dhrs7b DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair Rpa2 Rad9a Exo1 Bard1 Rbbp8 Palb2 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Wrn FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling Fgf22 Spred1 Spred2 Fgfrl1 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction Pals1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling Gab1 Egfr Pik3r1 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling Egfr HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones H2bu2 Meaf6 Yeats2 Hcfc1 Kansl2 Sap130 H2bc9 Vps72 H2bc7 H2bc8 Tada2a Rbbp7 Trrap Supt3 Msl1 Ruvbl2 Ruvbl1 H3c7 Usp22 Brd8 Elp1 Tada1 Elp6 Taf12 Phf20 Ing5 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion Psmb1 Psmc2 Psma7 Syvn1 Psmd12 Psmd11 Psma6 Hhat Psmd8 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands Tnfrsf10b Fas INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis Akt3 Akt2 Gsdmd Nmt1 Casp3 Gzmb Dynll1 Dynll2 Tfdp2 Tfdp1 C1qbp Akt1 Gsdme Mapk1 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Tab2 Ube2v1 Nod1 Irak1 Ripk2 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells Glul RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration Akt3 Akt2 Akt1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies Hmgcl Aacs INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR Areg Egfr RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape Ercc3 Taf7 Taf5 Taf2 Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression Ncoa6 Nrip1 Cpt1a SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants Fga Csk Fgg Camk2g Camk2d Camk2b Camk2a Arrb1 Map3k11 Apbb1ip Rap1a Phb1 Map2k2 Map2k1 Mapk1 Fgb DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism Lmbrd1 Cd320 Tcn2 Mtr Mmab MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal Mgmt ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) Plcg2 Irs2 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP Smad5 Amh Cer1 Bmpr1a Bmpr1b Bmpr2 Smad4 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Nuf2 Nup133 Dync1h1 Dynll1 Dync1i2 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cenpa Nsl1 B9d2 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Nudc Kif2c Ppp1cc Nup85 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism Bckdk Hibch Bckdhb Auh Ppm1k RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy Csnk2b Atg5 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants Fga Csk Fgg Camk2g Camk2d Camk2b Camk2a Arrb1 Map3k11 Apbb1ip Rap1a Phb1 Map2k2 Map2k1 Mapk1 Fgb BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair Parp2 H2bu2 Rfc1 Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Terf2 Pcna Terf2ip Rpa2 H2ax Nthl1 Rpa3 H2bc9 Parg H2bc7 Polb H2bc8 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones Sec31a Serp1 Ppp2r5b Gfpt1 Dctn1 Syvn1 Preb Yif1a Ern1 Klhdc3 Cxxc1 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters Abcb6 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules Psmb1 Psmc2 Psma7 Slc5a6 Slc10a6 Camk2g Apoe Camk2d Camk2b Camk2a Emb Prkar2a Prkar1a Prkacb Abcf1 Abca2 Abca8b Slc35a1 Slc8b1 Slc4a3 Slc2a4 Slco4c1 Mrs2 Azgp1 Nipal1 Slc17a8 Nipa1 Slc27a1 Asic4 Arl2bp Clca1 Slc29a3 Atp8a1 Slc28a2 Atp6v0a4 Slc27a6 Clcn2 Slc29a4 Clcn3 Clcn1 Atp4a Atp4b Atp11b Atp13a1 Atp8b3 Ttyh2 Sgk3 Sgk2 Atp12a Atp1a1 Scnn1b Atp9b Scnn1g Tcirg1 Slc9a4 Slc9a2 Slc30a3 Tpcn1 Ap2a2 Slc9a3 Slc30a2 Slc25a18 Tpcn2 Ap2a1 Slc39a5 Clcn6 Tsc22d3 Clcn7 Slc25a10 Clcn4 Atp1b1 Clcn5 Abcb6 Atp1b3 Atp6v1a Atp6v0d2 Phb1 Bsnd Pmpcb Atp6v1f Slc9b2 Slco4a1 Spg7 Phb2 Slco2b1 Micu1 Slco1c1 Mcu Slc16a2 Parl Slc13a5 Ftmt Stom Slc26a9 Slc2a12 Slc31a1 Slc20a1 Slc44a2 Atp6ap1 Slc13a1 Cptp Slc9a1 Slc5a4a Ca1 Fth1 Ca2 Slc12a6 Erlin2 Erlin1 Slc26a2 Slc5a1 Ano6 Slc6a2 Slc6a5 Abcd3 Slc20a2 Slc40a1 Aco1 Slc46a1 Slc35b3 Magt1 Slc22a12 Slc22a18 Heph Myo5b Atp2b2 Atp2b1 Slc8a1 Slco1b2 Slc8a2 Akap1 Gng3 Gnb2 Rhbg Gnb1 Vdac3 Mbtps1 Gnb4 Aqp6 Eif2s3x Eif2s2 Apoc2 Cyb5r2 Atp6v1h Cyb5r1 Apoc3 Slc16a3 Slc47a1 Slc25a26 Slc7a7 Slc7a8 Slc38a3 Trpc6 Trpv4 Slc7a11 Trpv6 Trpm8 Vdac1 Trpm4 Apoa1 Apoa2 Apoa4 Slc35d2 Pdzd11 Apobr Psmd12 Apoc1 Rab11a Psmd11 Mttp Apob Psma6 Psmd8 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing Polr2k Prpf8 Polr2g Snrnp35 Sf3b6 Prpf6 Snrnp25 Gtf2f1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation H2bu2 Jun Mamld1 Elf3 Notch3 E2f3 H3c7 Tfdp2 Tfdp1 Tnrc6a H2ax H2bc9 H2bc7 H2bc8 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription H2bu2 Ctbp1 Rbbp7 Tcf3 Kdm1a Zmym2 Mphosph8 Ezh2 H3c7 Mcrip1 Snai1 Pkm Zbtb33 H2ax Twist2 H2bc9 H2bc7 Mapk1 H2bc8 Hdac1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1qbp SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids Ltc4s Pon3 Pon1 Pon2 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase Cdk6 Tfdp1 Ptk6 Cdkn2b Ccne1 E2f2 Cdkn2a Ppp2r2a Cdkn2c E2f3 Tfdp2 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis B3galt2 Fut9 St3gal4 St3gal6 B4galnt2 Abo CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) Fzd6 Gng3 Gnb2 Wnt8a Glp2r Gnb1 Ramp2 Wnt7a Sct Gnb4 Ramp3 Wnt10b Ramp1 Wnt5a Fzd4 Gip Gipr Fzd7 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation Edem2 Alg8 Trappc4 Sptbn4 Sptb Alg3 Dync1h1 Rab1b St6galnac3 Dctn2 Stt3b Sptan1 St6gal1 Dynll1 Dync1i2 Ganab Rpn2 Csnk1d Rpn1 Dhdds Magt1 Rad23b Slc35a1 Sec22b St3gal4 Mgat4a Mgat4b St3gal1 Nudt14 Areg Ctsa Gmppa Tmem258 Dolpp1 Fcsk Golga2 Sec13 Cog2 Cog6 Bet1l Cog8 Capza1 Actr10 Rnf103 Nagk Amdhd2 Rnf139 Edem3 Gfpt1 Renbp Syvn1 Trim13 Uggt1 Uggt2 B4galnt2 St3gal6 Mgat3 St6galnac5 Dctn1 Gne Ank1 Man1a Ins2 Sec31a Kdelr2 Tmed9 Dynll2 Trappc10 Gorasp1 Preb Ppp6c Lman2 Sec22c Neu3 Sec23ip Trappc6b B4galt6 Ankrd28 Mgat5 Trappc6a Neu1 Dad1 Actr1a Cog1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex Ctbp1 Men1 Ctnnb1 Akt2 Tcf7l1 Akt1 Btrc Hdac1 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions Lifr Jak1 Tyk2 Osmr Crlf1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways Myog Myod1 Strap Itgav Tgfb2 Acvr1b Amh Cer1 Bmpr1a Bmpr1b Bmpr2 Ppp1r15a Usp15 Psen2 Plcg2 Smad5 Cav2 Ranbp9 Nrip1 Pip4k2c Stag2 Smc3 Tph1 Fkbp4 Tek Adh4 Gzmb Sh2d2a Col4a5 Mtmr4 Plcb4 Eif4ebp1 Col4a4 Col6a3 Syvn1 Klb Fgf15 Ier3 Phlpp1 Il33 Strn Pik3r5 Egr1 Akt1s1 Vps26a Snai1 Znrf3 Rspo1 Dact1 Tmed5 Lgr5 Lgr6 Dkk1 Avpr1b Jag2 Mras Ctbp1 Cilp Bex3 Grap Ppid Lats1 Hhat Sh3kbp1 Kdr Ffar1 Kremen1 Apbb1ip Mib1 Hes5 Dusp10 Pde3b Lbr Psap Ahcyl1 Apoc2 Memo1 Ins2 Trib3 Gga3 Ugt1a2 Pck1 Apoe Prokr1 Rgs2 Dgkb Lpar4 Lpar3 Lpar2 Lpar1 Prkch Dagla Xcl1 Grp Ffar3 Bdkrb2 Bdkrb1 Rgs17 Chrm5 Gnai2 P2ry2 P2ry1 Tac3 Gprc6a Opn4 Nmb Dgkk Lpar5 Cck Ppan Prok1 Dgkz Nms Ppp1cc Ltb4r2 Gast F2rl2 Fabp5 Fabp6 Gip Cdon Adra2a Igf1 Pik3cg Prkag2 Mtr Matk Ccl22 Ccl20 Ccl2 Ackr4 Cxcl5 Fshr Tshr Eepd1 Abcd3 Ptpn13 Igf2 Hgf Dock7 Gab1 Areg Fgf7 Fgf22 Myb Tcf7l1 Trib1 Tsc2 Kif18a Kif2c Klc2 Mfn1 Mfn2 Racgap1 Kdm1a Sh2b3 Rab7 Atp6v1h Cfl1 Rdh16f2 Crabp1 Dhrs9 Rdh14 Sdr16c5 Myh9 Lamtor2 Usp7 Prkag3 Mdm2 Pin1 Ramp2 Mlst8 Casp2 Flt4 Pml Mapkap1 Kdm4b Wwc1 Trrap Kdm1b Ruvbl1 Kdm3a Dsp Vangl2 Picalm Rnd3 Kctd13 Ktn1 Ankrd26 Ranbp10 Tmod3 Txnl1 Pkp4 Sema4f Lemd3 Tnfaip1 Ckap4 Kit Srgap1 Srgap2 Cdc42bpa Daam1 Cdc42ep1 Tpm3 Nckap1l Stk38 Tex2 Plxna1 Wipf3 Bcr Actr2 Ar Actr3 Prkcb Nr3c1 Btk Stom Rara Flna Arap2 Senp1 Syde2 Atp6ap1 Mcam Myh10 Ska1 Cpne8 Ahctf1 Myo6 Abl2 Nf2 Dynll2 Nipsnap2 Ptk2 Rasgrf2 Mgll Plxnd1 Csnk2b Cyba Cybb Nox3 Arpc4 Rab9 Spata13 Nudc Aldh3a2 Rhof Rhod Arhgef15 Egfr Arhgef17 Arhgef11 Arhgdig Nuf2 Rac2 Sptbn4 Noxa1 Emd Sptb Dync1h1 Git1 Iqgap2 Iqgap3 Arhgap15 Diaph2 Diaph3 Stam2 Arhgap17 Efhd2 Sptan1 Dynll1 Usp9x Fam13b Dync1i2 Fnbp1 Actn1 C1qbp Evl Lama2 Arhgap22 Rhobtb3 Scai Baiap2l1 Btrc Cenpa Golga3 Lamb2 Vma22 Pkn3 Ophn1 Was Nsl1 Plg Slitrk5 Slitrk3 Adam17 Nhs Cma1 Emc3 Csk Gopc B9d2 Myo9a Prex1 Mmp7 Wasf3 Casp3 Actc1 Wasf2 Taok1 Plekhg1 Tas2r39 Farp1 Mmp9 Tas2r38 Sh3bp1 Prag1 Abi2 Cenpm Pkn2 Cenpi Pkn1 Map3k11 H2ax Cenpf Arhgap42 Cbx4 Tas1r1 Tas1r3 Bmi1 Tnf Phc3 Hdac1 Tas2r16 Yy1 Scd1 H2bu2 Hdac5 Tas2r13 Men1 Tas2r137 Tas2r136 Ccnc Tas2r140 Tnfrsf1a Sharpin Birc3 Mib2 Tas2r119 Birc2 Axin2 Tas2r4 Tas2r7 Mef2c Polr2k Tas2r120 Tas2r107 H2bc9 H2bc7 H2bc8 Tas2r40 Tas2r41 Camk4 Rbbp7 Plat Cdk8 Cdk5 Npy Ptpn7 Gatad2a Ezh2 Ptprj H3c7 Zranb1 Cdkn2b S100a9 Csf2 Psmd12 Il2 Psmd11 Psma6 Psmd8 Smad4 Psmb1 Psmc2 Rit2 Htr6 Tcf3 Taar5 Ctnnb1 Psma7 Htr1a Sct Pde7b Apln Rgs8 Wnt10b Galr1 Camk2g Kel Rxfp1 Camk2d Mapk14 Pnoc Camk2b Grk6 Tas2r131 Camk2a Gpr83 Tas2r135 Opn3 Gper1 Gpsm3 Akt1 Gpsm1 Npbwr1 Ift52 Prkar2a Ramp1 Prkar1a Ppp1r1b Ptger2 Fuz Ptger3 Prkacb Rbx1 Grm8 Gpr20 Ift140 Gipr Itch Fgb Ift122 Fga Ptgir Gpr35 Wnt8a Rgs22 Fgg Glp2r F2 S1pr3 Wnt7a Rasa4 S1pr2 Nf1 Gpr37l1 Dab2ip Ackr1 Spred1 Cort Ramp3 Rasal3 P2ry13 Spred3 Gpr55 Spred2 Thbs2 Polr2g Nup107 Sec13 Atp6v0a4 Gtf2f1 Nup85 Nup133 Il2rb Ptpn2 Tcirg1 Ap2a2 Ap2a1 Ppp2r5e Frat2 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cdc37 Atp6v1a Erbin Atp6v0d2 Phb1 Atp6v1f Gnaz Cysltr1 Cab39 Opn1sw Jag1 Rag2 Myd88 Rag1 Gdnf Id4 Alk Mdk Irs1 Frs2 Pik3r1 Tec Tnrc6a Abhd17c Arrb1 Abhd17b Csf2ra Rce1 Irs2 Wnt5a Wnt5b Ppp3cb Gnat2 Fzd4 Fzd7 Fzd6 Pde6a Tbk1 Pde6b Akt3 Prickle1 Akt2 Jak1 Tyk2 Pik3r4 Mkrn1 Mapk4 Etv4 Rasgef1a Zdhhc9 Ube2l3 Golga7 Ripk2 Fgfrl1 Ptpn11 St3gal4 Rps27 Irak1 Tab2 Drd4 Drd5 Hnrnpa1 Eps15 Ccne1 Gna14 Gng3 Gnb2 Gnb1 Sphk1 Pde10a Pde11a Gnb4 Cct7 Pde1a St3gal6 Jun Mamld1 Elf3 Notch3 E2f3 Tfdp2 Flt3 Tfdp1 Stap2 Ptk6 Rnf146 Frk Sppl2b Dock1 Otulin Camkk2 Cbl C3ar1 Sppl2a Rhoa Nsmaf Dok1 Sfpq Epas1 Crk Eif4b Eif4e Fasn Ddx39b Gabbr2 Lrrc7 Trpc6 Strada Cab39l Tnfrsf10b Fas Traf2 Gabrb3 Ripk1 Bdnf Thbs4 Tgfbr1 Rap1a Map2k2 Map2k1 Dzip1 Mchr1 Mapk1 Apoc1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma Areg Egfr GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense Casp1 Gbp2 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination Lama2 Adgrg6 Mbp Pmp22 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins Npm1 Nup205 Nup133 Nup107 Sec13 Rcc1 Nup85 Nup88 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels Kcnj10 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance Atrx TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Itgav Ppp2r2a Ptk2 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway Or4n4 Or4a47 Ldb1 Gnb1 Or51f1d Or1i2 Or2t1 Or10h5 Or51e2 Or51m1 Or8i2 Or5p80 Or4c11 Or14j1 Or8h10 Or2ag1 Or10a4 Or12d17 Or10a5 Or10a2 Or5v1 Or52d1 Lhx2 Or51b6 Or6c76 Or10k2 Or51i2 Or2t44 Or51i1 Or8d1 Or7c70 Or2a7 Or10h1b Or10h28 Or52w1 Or5p6 Or5m10 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling Camk4 Gng3 Gnb2 Gnb1 Cdk5 Gnb4 Ahcyl1 Pde1a Gnai2 Camk2g Camk2d Camk2b Camk2a Ppp2r5d Plcb4 Camkk2 Prkar2a Prkar1a Ppp1r1b Mapk1 Ppp3cb Prkacb Gna14 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation Psmb1 Psmc2 Psma7 Itgav Kctd7 Hectd1 Erap1 Hectd3 Rnf220 Ube2b Pik3r4 Mkrn1 Blmh Ube2a Fbxl20 Rnf213 Btbd1 Btrc Rnf138 Ube2v1 Fbxw8 Asb16 Ube2l3 Rnf126 Rbx1 Dcaf1 Herc2 Fgb Fbxo21 Itch Fga Ubox5 Ube2r2 Rnf6 Uba6 Fgg Fbxo7 Cd207 Trim21 Sec22b Klhl25 Sec61a2 Klhl20 Klhl2 Spsb2 Fbxl14 Spsb1 Fbxl16 Trim37 Fbxl19 Lonrf1 Asb7 Rnf25 Rchy1 Ube2j1 H2-Q10 Sec13 Fbxw4 Mib2 Uba7 Btk Sec31a Myd88 S100a1 Tlr4 Ly96 Cdc34 Cyba Cybb Ube2c Fzr1 S100a9 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Psmd8 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD Cspg5 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling Psmb1 Psmc2 Psma7 Map3k14 Btrc Psmd12 Psmd11 Psma6 Psmd8 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair H2bu2 Exo1 Polh Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Wrn Clspn Rpa2 Rbbp8 Rpa3 H2bc9 H2bc7 H2bc8 Herc2 Parp2 Rfc1 Pold4 Pcna Polq Ppp4c Rad9a Bard1 Eme1 Mus81 Palb2 H2ax Ccna1 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism Pgm1 Galm Akr1b1 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways Akt3 Akt2 Akt1 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination H2bu2 H2ax Nthl1 H2bc9 H2bc7 Terf2 H2bc8 Terf2ip RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME Ada Nme1 Slc29a3 Slc28a2 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport Cptp TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment Ube2v1 Birc3 Birc2 Ripk1 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 Bdnf Frs2 Ptpn11 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System Itgav Pdxk Plcg2 Casp2 Pecam1 Gns Lgmn Gpi Siglec12 Asah1 Ecsit Dsp Man2b1 Ckap4 Sirpb1b Nckap1l Wipf3 Bin2 Actr2 Tasl Actr3 Ly86 Itgam Btk Irf5 Stom Pygb Agl Slc44a2 Pygl Cpne1 Cpne3 S100a1 Nf2 Ptk2 Cyba Csnk2b Cybb Arpc4 Unc93b1 Rhof Rac2 Dync1h1 Iqgap2 Sptan1 Acly Dynll1 Hpse Cd300a C1qbp C1qa Btrc Ctsg Was Klkb1 Trex1 Nlrc3 Nlrp4e Cgas Wasf3 Casp3 Wasf2 Mmp9 Abi2 Pgm2 Mgst1 Serpinb1a Pgm1 H2ax Psap H2bu2 Ahcyl1 Birc3 Birc2 Map3k8 Mef2c Polr2k Hsp90b1 Rab14 Prkdc H2bc9 H2bc7 H2bc8 Plau Serpinb6a Pafah1b2 Ptprj H3c7 Bpifb2 Bpifa1 Pdzd11 Rnase2b Prtn3 Otud5 Pglyrp2 Crp Art1 Colec10 Defb23 Reg3g Rab27a S100a9 Atox1 Chga Psmd12 Neu1 Psmd11 Psma6 Psmd8 Psmb1 Psmc2 Ctnnb1 Psma7 Mapk14 Polr3a Polr3d Polr3f Polr3k Prkacb Itch Fgb Fga Gaa F12 Fgg F2 Dera Muc1 Cfp Ctsa Cfd Cfb Muc4 Slco4c1 Cystm1 Pa2g4 Snap29 Clec4b2 Enpp4 Card9 Atp8a1 Atp6v0a4 Crispld2 Fabp5 Plekho2 Rab37 Hp Ilf2 Atp11b Ptprb Lamp1 Lamp2 Arl8a Rab3d Siglec15 C1qb C1rb Hexb Slpi Cr2 Dhx58 Cpn1 C7 Tcirg1 Uba7 Prcp C9 Rigi Cd46 Ap2a2 Cant1 Cpb2 Txk C1qc Dhx36 Vat1 Ppp2r5d Pkm Tollip Prg3 Rap2c Atp6v1a Atp6v0d2 Ampd3 Orm3 Atp6v1f Abca13 Cd3g Cab39 Irag2 Nkiras1 Anpep Cd63 Nkiras2 Peli1 Myd88 Dpp7 Usp14 Clec4e Idh1 Cpped1 Ms4a2 Rab5c Cnpy3 Pik3r1 Tec Fth1 Ppp3cb Tbk1 Ano6 Ifna16 Tlr7 Pik3r4 Ube2v1 Nod1 Golga7 Ripk2 Ptpn11 P2rx7 Pycard Magt1 Aim2 Sugt1 Itk Casp1 Trim21 Irak1 Tab2 Ctsh Gsdme Rbsn Myo10 Myo5a Capza1 Actr10 Pkp1 Gsdmd Atg5 Jun Frk Dock1 Map3k14 C3ar1 Rab7 Rhoa Nos2 Atp6v1h Crk Cfl1 Lrrc7 Myh9 Lamtor2 Traf2 Ripk1 Tlr4 Ly96 Cdc34 Rap1a Map2k1 Mapk1 Pin1 Apob GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism Gdpd5 Gdpd1 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism Gaa Nhlrc1 Taldo1 G6pc1 Slc37a4 Ppp1r3c Gns FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL Crls1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions Kdr Flt4 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism Smpd1 M6pr Asah1 Neu3 Hexb Psap Arsj Neu1 Arsi Ctsa NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Rpl4 Smg6 Smg5 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Etf1 Upf3a Gspt1 Pabpc1 Rpl22 Rpl18 Ppp2r2a Rps11 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 Jag1 Psmb1 Psmc2 Psma7 Mamld1 Hes5 Psen2 Flt4 Akt1 Psmd12 Rbx1 Psmd11 Psma6 Psmd8 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine H2bu2 H2ax Nthl1 H2bc9 H2bc7 Terf2 H2bc8 Terf2ip L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Pabpc1 Eif3l Eif3e Eif2s3x Eif2s2 Eif3b Eif3c Rpl22 Rpl18 Eif4b Eif4e Rps11 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage Gsdmd Casp3 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling Arrb1 Tgfb2 Tgfbr1 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism Fads1 Elovl5 Hsd17b4 Fads2 Elovl1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus Jag1 Psen2 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling Jak1 Tyk2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Igf1 Igf2 Trib3 Akt2 Cilp Klb Fgf15 Gab1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Irs2 Ptpn11 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins F10 F2 F9 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors Mef2c GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism Chp1 Glce Chsy3 Slc26a2 Chst2 St3gal6 Hexb Cemip Cspg5 Fam20b Hyal3 Hpse Ndst3 B3gnt2 Sdc3 Has3 Xylt2 Gns Gpc3 Slc35b3 Gpc2 Gpc4 Slc9a1 St3gal4 St3gal1 Hs6st2 Slc35d2 Hmmr B4galt6 Hs3st2 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 Flt3 Csk Cbl Sh2b3 Abl2 Ptprj POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair Parp2 Parg Polb REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity Cdk6 Tnrc6a Pml Ptpn11 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair Rpa2 Rfc1 Pold4 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Pcna Polb DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH Ggt1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex Men1 Strap Ccnc Itgav Cdk8 Tgfb2 Ppp1r15a Usp9x Usp15 Mtmr4 Tfdp2 Tfdp1 Cdkn2b Cbl Rhoa Tgfbr1 Ppp1cc Mapk1 Hdac1 Smad4 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis Ggps1 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs Kit ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs Npm1 Prkar1a Alk Hip1 Bcl11a Strn HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA Tnfsf13 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse Rhoa Myh10 Myh9 Arhgef11 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 Cfb LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells Ctnnb1 Cbl Sh3kbp1 Stam2 Eps15 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism Ranbp9 Me1 Rmnd5b CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane Arl6 Pkd2 Mchr1 Bbs7 Rab11a Exoc7 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance Apoe Apob PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import Pipox Phyh Amacr Hao2 Gstk1 Idh1 Pex7 Usp9x Zfand6 Hacl1 Hsd17b4 Decr2 Pex12 Nos2 Hmgcl Crat TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Npm1 Cnot7 Cnot6 Cnot9 Cpap Btg2 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) Sv2a TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation Atp6v1h Ap2a2 Ap2a1 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 Hgf BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P Taldo1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Akt1 Spr Gch1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes H2bu2 Ncapd3 H2ax H2bc9 H2bc7 H2bc8 H3c7 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis Psmb1 Adam17 Psmc2 Psma7 Syvn1 Psmd12 Psmd11 Psma6 Hhat Psmd8 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Jag1 Adam17 Jag2 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis Rpa2 Rfc1 Pold4 Rfc5 Rfc3 Pola2 Rpa3 Rfc4 Rfc2 Pcna SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes Mllt3 Exo1 Ssrp1 Apex2 Tcf3 Polh Taf7 Rfc5 Rfc3 Taf5 Rfc4 Taf2 Rfc2 Exosc9 Mad2l2 Exosc8 Rev1 Ctr9 Polr2k Exosc4 Dis3 Exosc6 Ncoa6 Exosc1 Exosc2 Mphosph6 E2f7 E2f8 Rfc1 Ctnnbl1 Pcna Ell Polr2g Myb Taf11 Aff4 Taf13 Taf12 Supt6 E2f2 Gtf2f1 Batf GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis Nhlrc1 Pgm1 Ppp1r3c INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins Nup205 Nup133 Nup107 Sec13 Psip1 Nup85 Nup88 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis H2bu2 Klf5 H3c7 Tfdp2 Tfdp1 Myb H2ax Gfi1 H2bc9 H2bc7 H2bc8 Fli1 Rara NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation Hexb Gns EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle Xrcc4 Psip1 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle Edem2 Ganab Rnf103 Rnf139 Edem3 Syvn1 Trim13 Uggt1 Uggt2 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense Casp1 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants Alk ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism Ptgr2 Ggt1 Cyp2c65 Ptgds Slc27a1 Ltc4s Cyp4f40 Pon3 Dpep1 Cbr1 Pon1 Pon2 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors Ramp2 Ramp1 Ramp3 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions Fga Kdr Fbn1 Pecam1 Fgg Itgav Col4a4 Icam5 Col18a1 Itgam Fgb CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation C1qc Crp C1qa C1qb C1rb PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO Senp1 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters Slc31a1 Slc9a1 Slc8b1 Slc9a4 Slc30a3 Slc9a2 Slc30a2 Slc9a3 Slc39a5 Heph Slc8a1 Slc8a2 Slc40a1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter Polr3d Polr2k Polr3f Polr3k Gtf3c2 Polr3a G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK Gng3 Gnb2 Gnb1 Gnb4 Btk SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a1 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion Apobec4 Apobec2 Apobec1 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle Cdk6 Psmb1 Psmc2 Exo1 Rab1b Psma7 Rfc5 Mybl2 Rtel1 Rfc3 Rfc4 Rfc2 Cdkn2c Clspn Wrn Mapk14 Zfp385a Npm1 Rpa2 Sun1 Rbbp8 Stag3 Mlh3 Rec8 Akt1 Rpa3 Smc1b Wapl E2f6 Stag2 Smc3 Rbx1 Cdk11b Rfc1 Pold4 Ruvbl2 Ruvbl1 Polr2g Nup205 Nup107 Sec13 Ppp1cc Rcc1 Nup85 Chmp3 Nup88 Chmp6 Nup133 Lemd3 Ppp2r5e Ppp2r5d Ppp2r5c Tyms Ppp2r5b Ppp2r5a Stn1 Dscc1 Prkcb Nek9 Nek6 Ska1 Ahctf1 Dynll2 Csnk2b Gorasp1 Tubgcp5 Ube2c Ppp6c Tubgcp4 Lpin1 Nudc Fzr1 Anapc11 Anapc10 Cdkn2a Ankrd28 E2f2 Pif1 Anapc1 Nedd1 Actr1a Tuba1a Nuf2 Cdk5rap2 Cep250 Akt3 Sdccag8 Emd Akt2 Cop1 Dync1h1 Ajuba Cep78 Gmnn Pcm1 Dctn2 Orc1 Orc2 Cep164 Foxm1 Ssna1 Cpap Tubg1 Dynll1 Ccnb2 Alms1 Dync1i2 Cep135 Cep63 Cep152 Haus4 Cnep1r1 Haus5 Csnk1d Btrc Cenpa Herc2 Nsl1 Pkmyt1 Ncapd3 Mau2 B9d2 Rps27 Taok1 Cenpm Lbr Cenpi H2ax Hmmr Golga2 Cenpf Pola2 Kif18a Kif2c Ccne1 Phf20 Tubb2a Hdac1 Tubal3 H2bu2 Terf2 Atrx Terf2ip E2f3 Tfdp2 Mis18a Rsf1 Tfdp1 Polr2k Lcmt1 Ptk6 H2bc9 H2bc7 H2bc8 Rbbp7 Phlda1 Pcna Pcbp4 H3c7 Nop10 Dkc1 Rad9a Bard1 Cdkn2b Gins2 Gins1 Mcm8 Cdc45 Mapk1 Ppp2r2a Mdm2 Psmd12 Psmd11 Psma6 Ccna1 Psmd8 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants Jag1 Adam17 Mib1 Mib2 Jag2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle Racgap1 Mcam Iqgap3 Prex1 Diaph3 Pik3r1 Daam1 C1qbp Pkn2 Lbr Abcd3 Pkn1 Rhoa Erbin Bcr Pkn3 Ophn1 Arhgef17 Arhgef11 Stom REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP Men1 Msln Ktn1 Mbtps1 Ckap4 Calu Apoe Hsp90b1 Lamb2 Ctsg Plg Gpc3 Fga Igf1 Fbn1 Igf2 Fgg F2 Mgat4a Apoa1 Apoa2 Prss23 Bpifb2 Mmp1a Mxra8 Fam20a Igfbp5 Igfbp4 Ccn1 Igfbp6 Cdh2 Vwa1 Apob DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina Emd Cnep1r1 Lpin1 Lemd3 Prkcb XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics Arnt2 Cyp2s1 Cyp2d22 Cyp2c65 Arnt H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD Bckdhb Ppm1k NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus Psen2 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA Hadha DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) Elovl6 Ncoa6 Mbtps1 Sc5d Acacb Mtf1 Fasn Ggps1 Scd1 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome Mapk1 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors Pfkfb1 Prkacb DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) Slc12a6 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis Rnf213 Sfpq Mapk1 Ctsg MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein Srpk1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) Parp2 Rbbp8 Polq TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer Tgfbr1 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair Exo1 Rfc5 Rfc3 Rfc4 Rfc2 Wrn Rpa2 Rad9a Bard1 Rbbp8 Palb2 Nthl1 Rpa3 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion Psmb1 Psmc2 Tcf3 Ctnnb1 Psma7 Strap Zmym2 Ilf3 Hoxc8 Ganab Rpn2 Rpn1 Tmem258 H2ax Eps15 Hdac1 H2bu2 Pcsk7 Kdm1a Cdh8 Cdh19 Mphosph8 Mcrip1 Pkm Cdh24 Snai1 Klf9 Zbtb33 Zc3h12a Twist2 Foxp2 H2bc9 H2bc7 H2bc8 Ctbp1 Rbbp7 Ezh2 H3c7 Cdh11 Tnrc6a Csnk2b Foxa2 Mapk1 Psmd12 Mdm2 Psmd11 Banp Psma6 Dad1 Psmd8 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation Kdr Sphk1 Ahcyl1 Prkcb SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 Csnk2b Itgav Map2k2 Map2k1 Mapk1 Egfr L1cam TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars Slc35d2 Slc35b3 Slc35a1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance Apobr Apoc1 Apoa1 Ap2a2 Apoe Apob Ap2a1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG Mgll Dagla METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100a9 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism Man2b1 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions Cyp2s1 Cyp2d22 Cyp2c65 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis Slc35a1 Nagk Amdhd2 Gfpt1 St3gal4 Renbp St6galnac3 St3gal6 St3gal1 Nudt14 St6gal1 Ctsa St6galnac5 Gmppa Dolpp1 Fcsk Gne Neu3 Dhdds Neu1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling Klb Fgf15 Frs2 Ptpn11 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB Myd88 Irak1 Ripk2 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases Rit2 Ctnnb1 Itgav Mlst8 Apoe Mapk14 Psen2 Flt4 Mapkap1 Ranbp9 Akt1 Tph1 Prkacb Itch Sh2d2a Spred1 Col4a5 Spred2 Thbs2 Polr2g Col4a4 Col6a3 Atp6v0a4 Gtf2f1 Ranbp10 Ptpn2 Klb Fgf15 Kit Tcirg1 Ap2a2 Ap2a1 Egr1 Ppp2r5d Nckap1l Cdc37 Atp6v1a Erbin Atp6v0d2 Atp6v1f Prkcb Igf1 Atp6ap1 Cilp Grap Id4 Alk Mdk Irs1 Frs2 Ptk2 Pik3r1 Tec Cyba Cybb Sh3kbp1 Irs2 Matk Egfr Kdr Akt3 Akt2 Stam2 Pik3r4 Lama2 Lamb2 Fgfrl1 Plg Ptpn11 Adam17 Cma1 Igf2 Csk Wasf3 Hgf Wasf2 Dock7 Gab1 Areg Mmp9 Fgf7 Abi2 Fgf22 Pde3b Tab2 Trib1 Hnrnpa1 Eps15 Hdac1 Sphk1 Ahcyl1 Sh2b3 Flt3 Polr2k Mef2c Ptk6 Dock1 Cbl Rhoa Atp6v1h Memo1 Crk Ins2 Trib3 Plat Cdk5 Ptprj Gabrb3 Thbs4 Bdnf Gga3 Rap1a Map2k2 Map2k1 Mapk1 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET Ranbp10 Ptpn2 Stam2 Hgf Dock7 Gab1 Ptprj Ptk2 Pik3r1 Lama2 Cbl Sh3kbp1 Gga3 Ranbp9 Rap1a Lamb2 Crk Eps15 Ptpn11 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Prnp Otof Serp1 Emd Get1 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 Psmb1 Psmc2 Cop1 Psma7 Psmd12 Psmd11 Psma6 Psmd8 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion Chmp6 Pdcd6ip Ubap1 Tsg101 Mvb12a Chmp3 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D Psmb1 Psmc2 Psma7 Psmd12 Psmd11 Psma6 Psmd8 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 Exo1 Bard1 Rbbp8 Palb2 Wrn REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide Ca3 Ca2 Car7 Car6 Car14 Ca1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation Ell Polr2k Polr2g Ssrp1 Gtf2f1 ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes Exo1 Rfc1 Polh Rfc5 Rfc3 Rfc4 Rfc2 Pcna Mad2l2 Rev1 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence H2bu2 Cdk6 Mink1 Map3k5 Jun Cdkn2c Mapk14 E2f3 Tfdp2 Tfdp1 Map4k4 H2bc9 H2bc7 H2bc8 Rbbp7 Ezh2 H3c7 Tnrc6a Cdkn2b H2ax Cbx4 Mapk1 Bmi1 Cdkn2a Mdm2 E2f2 Phc3 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription Plxnd1 Wwc1 Mamld1 Notch3 Hes5 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria Tfdp1 Tfdp2 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) Slc5a1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation Tab2 Tlr4 Ly96 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway Kdr Ctnnb1 Akt3 Akt2 Sphk1 Itgav Ahcyl1 Mlst8 Mapk14 Dock1 Rhoa Nckap1l Mapkap1 Akt1 Crk Prkacb Prkcb Trib3 Wasf3 Sh2d2a Wasf2 Ptk2 Pik3r1 Abi2 Cyba Cybb DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation Adam17 Mmp20 Mmp12 Mmp7 Mmp19 Mmp9 Tmprss6 Mmp1a Mmp10 Col15a1 Col17a1 Col18a1 Col12a1 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle Prkag2 Cpt1a UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin Cd9 Txnrd1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade Trib3 Akt2 Klb Fgf15 Gab1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Irs2 Ptpn11 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Eif3l Eif3e Eif3b Eif3c Rpl22 Rpl18 Rps11 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade Nkiras2 Peli1 Myd88 Usp14 Jun Irak1 Traf2 Mapk14 Map3k8 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ecsit Ripk2 Nkiras1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated Ppp2r5e Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis Ppa1 Ppa2 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation Polr3d Polr2k Polr3f Polr3k Snapc1 Snapc2 Gtf3c2 Gtf3a Brf2 Polr3a Ssb SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants Zmym2 Bcr Pik3r1 Fgfr1op2 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing Pabpn1 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways Rpl4 Rpl39 Rpl7 Mlst8 Med8 Npm1 Plcg2 Pml Rpl22 Mapkap1 Fkbp4 Brms1 Ppib Med28 Phf5a Tyro3 Rpl18 Cldn1 Nr3c1 Btk Brd4 Xab2 Sf3b6 Ctnnbl1 Snrpn Mapre3 Bag2 Cherp Dynll2 Kpna4 Sigmar1 Ly6e Chmp1a Csnk2b Isy1 Sh3kbp1 Puf60 Ppil4 Ppil1 Il1r1 Egfr Cog1 Grpel1 Dync1h1 Hnrnpr Elavl2 Sugp1 Ctr9 Dynll1 Nudt21 Dync1i2 Cd300a Srrm2 C1qa Btrc Prpf6 Ppig Ppih Prpf8 Wbp11 Rtn3 Pqbp1 Cgas Oas2 Blnk Dnaja2 Eif4g3 Taok1 Mmp9 Med23 Sap30l Med24 Hdac1 H2bu2 Sap30 Ccnc Med16 Med17 Polr2k Gtf2h2 Gtf2h3 Gtf2h5 H2bc9 H2bc7 H2bc8 Med31 Ercc3 Rbbp7 Cdk8 Psip1 Gatad2a Apoa1 Ezh2 H3c7 Psmd12 Psmd11 Psma6 Psmd8 Smad4 Psmb1 Psmc2 Ctnnb1 Psma7 Nrbp1 Camk2g Camk2d Camk2b Pabpc1 Camk2a Akt1 Rbx1 Itch F2 Ell Polr2g Ubap1 Nup205 Nup107 Tsg101 Sec13 Ifit3b Vps25 Taf11 Mvb12a Ppp1cc Taf13 Taf12 Rcc1 Gtf2f1 Nup85 Chmp3 Nup88 Chmp6 Pdcd6ip Ssrp1 Nup133 Xrcc4 Taf7 Nmt1 Taf5 Atp1a1 Taf2 Uba7 Rigi Comt Ap2a2 Ap2a1 Atp1b1 Atp1b3 Cysltr1 Ap1s3 Rab5c Pik3r1 Mgat5 Dad1 Rps11 Tufm Edem2 Tbk1 Akt3 Akt2 Jak1 St6galnac3 Iscu Tyk2 Vps33a Vps33b Stt3b Ano6 St6gal1 Ifna16 Tlr7 Zdhhc3 Pik3r4 Ganab Rpn2 Sdc3 Zdhhc9 Rpn1 Vps11 Ube2v1 Nod1 Pals1 Vps16 Golga7 Ripk2 Sftpd Ptpn11 Gpc3 Gpc2 Pycard Magt1 Gpc4 Uba6 Rps25 Casp1 Rps26 St3gal4 Rps27 Mgat4a Mgat4b St3gal1 Irak1 Il17f Rps21 Il17a Srpk1 Gemin2 Tmem258 Tab2 Ddx20 H2-Q10 Hnrnpa1 Hmg20b Kdm1a Atp6v1h Pabpn1 Eif4e Fasn Snrpa1 Dhx38 Hnrnpa2b1 U2af1l4 Ripk1 Tlr4 Ly96 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Pou5f1 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication H2bu2 Psmb1 Psmc2 Mgme1 Psma7 Rfc5 Rfc3 Gmnn Orc1 Rfc4 Orc2 Rfc2 Rpa2 Polg2 Twnk Rpa3 H2bc9 H2bc7 H2bc8 Rbx1 Rfc1 Pold4 Pcna H3c7 Gins2 Gins1 H2ax Mcm8 Cdc45 Pola2 Ube2c Fzr1 Anapc11 Ccne1 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling Lifr Cbl Jak1 Tyk2 Osmr Crlf1 Ptpn11 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway Pycard PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis Inhbc BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 Hexb PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization Hscb Grpel1 Pipox Serp1 Emd Tomm6 Phyh Amacr Tomm7 Gstk1 Slc25a17 Bcs1l Usp9x Abcd3 Decr2 Pex12 Nos2 Pmpcb Hmgcl Mtx2 Ndufb8 Fis1 Timm21 COA4 Chchd10 Timm17b Hao2 Vdac1 Idh1 Pex7 Zfand6 Hspa9 Hacl1 Prnp Otof Hsd17b4 Get1 Crat SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway Sh3kbp1 Reln SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer Tgfbr1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome Pycard Aim2 Casp1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor Grik5 Grik4 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis Mgll Dgkk Prkch Trpc6 Dagla Dgkz Dgkb LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis B3galt2 Fut9 St3gal4 St3gal6 B4galnt2 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins Fga Fgg Apbb1ip Rap1a Fgb Ptk2 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism Fads1 Elovl5 Fads2 Elovl1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein Ganab RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes Ints7 Ints2 Ints3 Snapc1 Snapc2 Nabp2 IntS13 Ints11 Taf5 Rprd2 Ell Polr2k Polr2g Taf11 Taf13 Gtf2f1 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism Adra2a Csf2ra Sftpa1 Ctsh Dmbt1 Ckap4 P2ry2 Sftpd PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses Ppfia2 Slitrk6 Slitrk3 Lrrc4b Ppfia4 Lin7c Rtn3 Slitrk2 Syt2 Syt9 Sharpin Lrrtm1 Lrrtm3 Dlgap4 Homer1 Nlgn3 Slitrk5 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function Psmb1 Psmc2 Ctnnb1 Psma7 Eps15 Psmd12 Mdm2 Psmd11 Banp Psma6 Psmd8 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway Jak1 Ccnc Tyk2 Med16 Med17 Rigi Ifna16 Tlr7 Med8 Sdc3 Rbx1 Gpc3 Med31 Gpc2 Gpc4 Cdk8 Oas2 Rab5c Tlr4 Ly96 Csnk2b Med23 Med24 Ppp1cc Egfr Med28 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type Cspg5 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion Ins2 Gng3 Gnb2 Adra2a Gnb1 Gnb4 Ahcyl1 Ffar1 Gnai2 Kcns3 Kcnb1 Rap1a Kcng2 Prkar2a Prkar1a Prkacb Akap5 Gna14 Acsl3 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity Mapk1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery Ell Polr2k Polr2g Ssrp1 Gtf2f1 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation Aimp1 Gars1 Yars1 Vars1 Farsa Tars1 Ppa1 Ppa2 Iars1 Aars2 Wars2 Pars2 Yars2 Ears2 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling Trim21 Jak1 Oas2 Trim62 Irf6 Irf9 Trim38 Camk2g Gbp2 Trim31 Camk2d Mt2 Camk2b Gbp7 Camk2a Pml H2-Q10 Trim8 Mapk1 Irf5 Ptpn11 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones Mbtps1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification Trappc4 Sptbn4 Sptb Dync1h1 Rab1b Dctn2 Dynll1 Sptan1 St6gal1 Mgat3 Dync1i2 Dctn1 Csnk1d Ank1 Man1a Ins2 Sec31a Sec22b St3gal4 Mgat4a Mgat4b Kdelr2 Tmed9 Dynll2 Areg Trappc10 Golga2 Sec13 Gorasp1 Preb Ppp6c Lman2 Cog2 Sec22c Cog6 Sec23ip Bet1l B4galt6 Cog8 Trappc6b Ankrd28 Mgat5 Capza1 Trappc6a Actr1a Actr10 Cog1 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events Camk4 Camk2a Camkk2 Prkar2a Pde1a Prkar1a Prkacb Camk2g Camk2d Camk2b CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants Alk LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy Chmp6 Ubap1 Tsg101 Mvb12a Plin2 Chmp3 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases Arsj Arsi CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism Aldh7a1 Slc44a2 Dmgdh Chdh DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 Fgf7 Fgf22 Gab1 Frs2 Ptpn11 Pik3r1 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters Slc20a1 Slc20a2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation Tab2 Ube2v1 Nod1 Irak1 Ripk2 Mapk14 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 Jag1 Psen2 Plxnd1 Wwc1 Mib1 Mib2 Mamld1 Jag2 Notch3 Egfr Hes5 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency Rpl4 Trib3 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Eif2s3x Eif2s2 Rpl22 Rpl18 Rps11 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events Ppp2r5d Cdk5 Prkar2a Ppp1r1b Prkar1a Ppp3cb Prkacb MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 Hgf Gab1 Ptpn11 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes P2rx7 Cacna1h Itgav Akt1 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling Akt3 Akt2 Strada Cab39l Prkag2 Lamtor2 Mlst8 Akt1s1 Tnrc6a Eif4ebp1 Prkag3 Tsc2 Akt1 Eif4b Eif4e Cab39 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde Camk4 Camkk2 Camk2g Camk2b AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis Agmat GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling Areg Egfr DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization Catsper4 Zp3 Cd9 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) Ggt1 Ltc4s Cyp4f40 Dpep1 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmb1 Psmc2 Psma7 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex Pbrm1 Phf10 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland Areg MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Exosc9 Exosc8 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psmb1 Psmc2 Psma7 Ube2c Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events Rap1a Map2k2 Crk Map2k1 Mapk1 Frs2 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism Slc25a10 Cbs Ethe1 Enoph1 Ahcy Mtr Gadl1 Mpst Cdo1 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle Mfn1 Mfn2 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense Gbp2 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition Psmb1 Psmc2 Akt3 Akt2 Psma7 Gmnn Orc1 Orc2 Tfdp2 Tfdp1 Rpa2 Ptk6 Tyms Akt1 Rpa3 E2f6 Pcna Mcm8 Cdc45 Pola2 Ccne1 Psmd12 Psmd11 Hdac1 Psma6 Ccna1 Psmd8 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) Elovl6 Ncoa6 Sc5d Acacb Mtf1 Fasn Ggps1 Scd1 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated Ppp2r5e Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination Mterf1b VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance Apobr Apoc1 Apob MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase H2bu2 Emd Nup133 Rab1b Lemd3 Ccnb2 Cnep1r1 H2bc9 H2bc7 H2bc8 Prkcb Ncapd3 Nek9 Nek6 H3c7 Nup205 Nup107 H2ax Golga2 Sec13 Gorasp1 Lpin1 Mapk1 Nup85 Nup88 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes Pcna Cpap Pcbp4 Zfp385a Tfdp2 Npm1 Tfdp1 Cnot7 Cnot6 Cnot9 E2f7 Ccne1 E2f8 Btg2 Ccna1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex Mcm8 Orc1 Orc2 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 Stap2 Bach1 Ptk6 Cox6a1 Ncoa6 Cox6a2 H13 Higd1c RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function Cdh11 Hoxc8 Tnrc6a Cdh24 Snai1 Ctnnb1 Cdh8 Ilf3 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity Ing2 Exo1 Meaf6 Akt3 Akt2 Rfc5 Rfc3 Rfc4 Rfc2 Dyrk2 Mlst8 Wrn Mapk14 Zfp385a Rpa2 Rbbp8 Pml Mapkap1 Ttc5 Akt1 Rpa3 Hipk1 Pip4k2c Taf11 Taf13 Taf12 Phf20 Hdac1 Ssrp1 Taf7 Taf5 Taf2 Ppp2r5c Rbbp7 Prkag2 Cdk5 Trp53rkb Pou4f1 Gatad2a Usp7 Rffl Rad9a Csnk2b Bard1 Prkag3 Jmy Mdm2 Pin1 Banp Ccna1 Ing5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Gng3 Gnb2 Kcns3 Gnb1 Kcnb1 Gnb4 Rap1a Kcng2 Prkar2a Prkar1a Akap5 Prkacb PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination H2bu2 Ube2r2 Ube2t Uba6 Pcna Ctr9 Usp7 Usp9x Cdc34 Ube2b Rnf152 Rnf40 Otulin Rnf144a Ube2a H2-Q10 Pex12 Prkdc Ube2c Tmem129 H2bc9 H2bc7 Ube2l3 H2bc8 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Csf2 Prkcb DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis Traf2 Ripk1 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells Lama2 Lamb2 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing Trmt61a Tprkb Ctu2 Nup133 Trmt10c Prorp Elac2 Trp53rkb Pop7 Trmt112 Pop4 Pop1 Rtcb Rpp21 AI597479 Rtraf Rpp14 Rpp40 Hsd17b10 Nup205 Nup107 Yrdc Mto1 Sec13 Pus3 Nup85 Trmt10a Nup88 Trmt13 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly Prkacb Apoa1 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants Kit CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis Tmlhe NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response Eif3l Eif3e Rps25 Eif3b Rps26 Eif3c Ifit3b Rps27 Rps21 Rps11 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 Fgfr3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Rac2 Klb Fgf15 Kit Ier3 Il33 Strn Pik3r5 Flt3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Akt1 Pip4k2c Ptpn11 Ins2 Myd88 Pik3cg Hgf Irak1 Gab1 Irs1 Areg Frs2 Pik3r1 Fgf7 Bdnf Fgf22 Irs2 Mapk1 Egfr TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes Casp2 Cradd Casp1 Pidd1 Bcl2l14 Rabggta Prelid1 Tnfrsf10b Fas Prelid3a Perp THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism Gpc3 Gpc2 Gpc4 Sdc3 Slc26a2 Hexb Cspg5 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters Psmb1 Psmc2 Lmbrd1 Nup133 Erlin2 Psma7 Erlin1 Slc26a2 Slc5a1 Slc6a2 Slc6a5 Slc20a2 Abcb6 Slc40a1 Avpr1b Slc7a7 Slc35a1 Slc22a12 Slc22a18 Apoa1 Heph Gck Nup205 Nup107 Slc12a6 Slc17a8 Sec13 Slco1b2 Slc29a3 Psmd12 Psmd11 Nup85 Psma6 Psmd8 Nup88 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ Lamp2 Tgfb2 Wdr1 Ola1 Nhlrc2 Calu Endod1 Lefty2 Sytl4 Clec3b Manf Actn1 Lgals3bp Apoh Pecam1 Cyb5r1 Orm3 Cfl1 Selp Prkcb Plg Fgb Cd63 Fga Igf1 Flna Igf2 Fgg Hgf Cd9 Apoa1 Cfd Ttn Psap DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling Tbk1 Tnfrsf1a Sharpin Birc3 Mib2 Birc2 Psen2 Casp2 Sppl2b Otulin Rhoa Sppl2a Nsmaf Ube2l3 Ripk2 Adam17 Myd88 Prex1 Bex3 Casp3 Tnfrsf10b Irak1 Fas Traf2 Ripk1 Rasgrf2 Tab2 Tnf Arhgef15 Arhgef17 Hdac1 Arhgef11 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication Tfdp1 Mcm8 Pola2 Orc1 Orc2 Tfdp2 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression Arnt2 Arnt Ccnc Med16 Med17 Mtf1 Med8 Cyp7a1 Ncoa6 Esrra Me1 Cpt1a Thrap3 Med31 Trib3 Ppargc1b Fhl2 Cdk8 Apoa1 Apoa2 Fads1 Med23 Slc27a1 Med24 Plin2 Txnrd1 Med28 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors Ffar3 Ffar1 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function Exo1 Bard1 Rbbp8 Palb2 Wrn RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle Ankrd26 Txnl1 Pkp4 Ptpn13 Lemd3 Plxna1 Aldh3a2 Dsp Vangl2 Frs2 Pik3r1 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome Csk Gab1 Areg Egfr Ptpn11 Pik3r1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication Rtn3 Magt1 Nmt1 Dnaja2 Eif4g3 Stt3b Bag2 Apoa1 Kpna4 Pabpc1 Tmem258 Rpn2 Rpn1 Eif4e Fasn Dad1 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Cdc34 Ube2b Ube2r2 Ube2t Uba6 Otulin Ube2a Ube2c Ube2l3 Usp9x Usp7 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling Rag2 Rag1 Jak1 Irs2 Il7r Hgf Crlf2 Irs1 H3c7 Pik3r1 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants Flt3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis Dct NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation Atp6v1h Ap2a2 Ap2a1 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint Pkmyt1 Ccnb2 Ccna1 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling Psmb1 Psmc2 Csk Itk Psma7 Ptprj Pik3r1 Ptpn22 Cdc34 Plcg2 Tab2 Evl Btrc Ube2v1 Psmd12 Was Cd3g Psmd11 Ripk2 Psma6 Psmd8 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis Polr2k Polr2g Nup205 Nup133 Nup107 Sec13 Gtf2f1 Nup85 Nup88 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate Cryl1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 Cdk6 Tfdp1 Ptk6 Cdkn2b Ccne1 E2f2 Cdkn2a Ppp2r2a Cdkn2c E2f3 Tfdp2 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases Stap2 Ptk6 Dock1 Cbl Rhoa Dok1 Sfpq Akt1 Epas1 Crk Ccne1 Nr3c1 Egfr TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Rfc1 Usp10 Polh Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Pcna Mad2l2 Uba7 Rev1 Rpa2 Rchy1 Rpa3 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants Kit GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis Pfkfb2 Pfkfb1 Nup133 Eno2 Pfkp Ppp2r5d Gck Nup205 Gpi Nup107 Sec13 EG433182 Prkacb Nup85 Pfkfb4 Nup88 Pfkfb3 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC Tubal3 Tuba1a Cct7 Tubb2a ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures Mmp20 Mmp7 Col4a5 Mmp9 Bmp1 Tll1 Col4a4 Col15a1 Col6a3 Pxdn Col18a1 Itgb4 Loxl1 Loxl3 Plec TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 Tbk1 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway H2-Q10 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels P2rx7 Trpc6 P2rx4 Orai2 Stim1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors Lpar4 Ppan P2ry13 P2ry2 P2ry1 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste Tas2r13 Tas2r137 Calhm1 Gnb1 Tas2r136 Tas2r140 Scnn1b Trpm4 Tas2r119 Scnn1g Tas2r4 Tas2r39 Tas2r7 Tas2r38 Tas2r120 Otop1 Tas2r107 Tas1r1 Tas1r3 Tas2r16 Tas2r40 Tas2r41 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Jag1 Adam17 Jag2 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type Mmab DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis Neu1 Ctsa MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling Lama2 Lamb2 Hgf Ptk2 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand Rpa2 Pold4 Rpa3 Terf2 Pcna Wrn Terf2ip EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling Git1 Ephb1 Ephb3 Ephb4 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling Cbl Jak1 Tyk2 Ptpn11 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL Nodal Dand5 Acvr1b Cer1 Mapk1 Lefty2 Smad4 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation H2bu2 H2ax H2bc9 H2bc7 H2bc8 H3c7 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism Nup133 Jak1 Eif4g3 Uba7 Rigi Kpna4 Nup205 Nup107 Sec13 Eif4e Pin1 Nup85 Nup88 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions Mt4 Mtf1 Mt2 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) Gng3 Gnb2 Arrb1 Gnb1 F2 Gnb4 Mapk1 F2rl2 Gna14 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling Mapk1 Capza1 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling Il21 Il21r Csf2ra Jak1 Il15 Il2rb Csf2 Il2 Pik3r1 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane Slc7a7 Slc7a8 Slc38a3 Slc7a11 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends H2bu2 H2ax H2bc9 H2bc7 Terf2 H2bc8 Terf2ip RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2bu2 H2ax Nthl1 H2bc9 H2bc7 Terf2 H2bc8 Terf2ip REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t Pgm1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters Slc22a12 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE Rasgrf2 Psen2 Casp2 Prex1 Bex3 Casp3 Arhgef15 Arhgef17 Arhgef11 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 Nkiras2 Myd88 Ripk1 Nkiras1 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC Pla2g3 Lpcat4 Plaat3 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly Tuba1a Chmp6 Tubal3 Nup133 Emd Lemd3 Ahctf1 Ccnb2 Lbr Nup205 Nup107 Sec13 Ppp2r2a Rcc1 Tubb2a Nup85 Chmp3 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family Plcg2 Clec4e Clec4b2 Muc1 Muc4 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 Fgf7 Fgf22 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease Gab1 Frs2 Pik3r1 GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins Lin7c Syt2 Syt9 Sharpin Lrrtm1 Lrrtm3 Dlgap4 Homer1 Nlgn3 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) Slc20a2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation Colec10 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) Cdh11 Ctnnb1 Dock1 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3cg Irs2 Gab1 Pik3r5 Pik3r1 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis Myh9 Wasf3 Wasf2 Ptk2 Abi2 Dock1 Nckap1l Arpc4 Wipf3 Crk Mapk1 Actr2 Myo10 Actr3 Myo5a Was Cd3g Btk DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function Bard1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane Ano6 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification Ptrh2 Hif3a Ing2 Usp44 Usp37 Usp20 Usp25 Wdr20 Usp28 Usp12 Usp19 Calu Wrn Usp15 Npm1 Pml Nrip1 Stag2 Smc3 Xpc Ddb1 Rad23a Rad23b Trrap Cops8 Dcaf10 Cops7a Ccdc22 Kdm1b Cops7b Commd4 Neurl2 Nae1 Dcaf4 Ankrd9 Wsb2 Ttll6 Dda1 Agbl5 Ruvbl1 Ttll5 Dcun1d3 Etf1 Agbl1 Vash1 Usp22 Vash2 Agtpbp1 Ktn1 Rnf103 Rnf139 Edem3 Syvn1 Trim13 Uggt1 Uggt2 Ckap4 Il33 Dctn1 Pias3 Ar Nr3c1 Vdr Rara Ctbp1 Senp1 Sec31a Dynll2 Prss23 Mxra8 Fam20a Ly6e Igfbp5 Igfbp4 Ccn1 Rab9 Vwa1 Gorasp1 Ppp6c Lman2 Sec22c Sec23ip Ankrd28 Rab2b Actr1a Cog1 Rab25 Tuba1a Rab17 Alg8 Sptbn4 Alg3 Sptb Dync1h1 Dctn2 Stam2 Ctr9 Sptan1 Dynll1 Usp9x Dync1i2 Csnk1d Btrc Lamb2 Dhdds Fbn1 Adamts1 Cbx4 Satb1 Bmi1 Phc3 Hdac1 Yy1 H2bu2 Men1 Nagk Amdhd2 Gfpt1 Renbp Mbtps1 Hcfc1 Birc3 B4galnt2 Birc2 Axin2 Mgat3 Hsp90b1 Rnf152 Rnf40 Rnf144a Rab14 Pex12 Prkdc Tmem129 Folr2 H2bc9 H2bc7 H2bc8 Ins2 Rbbp7 Pcgf2 Vdac1 Satb2 Apoa1 Apoa2 Bpifb2 Otub1 Zranb1 Otud5 Trappc10 Rab27a Neu3 Rab11b B4galt6 Trappc6b Psmd12 Rab13 Neu1 Trappc6a Psmd11 Psma6 Psmd8 Smad4 Psmb1 Rab38 Psmc2 Trappc4 Psma7 Rab1b Arsj Mitf Arsi Clspn Apoe B3gnt2 Rbx1 Fga F10 Fkrp Slc35a4 Slc35a1 Crppa Fgg F2 Large2 Fktn F9 Muc1 Adamts20 Adamts10 Sema5a Thsd7a Cfp Ctsa Thbs2 Muc4 Adamtsl5 Thsd4 Nup205 Nup107 Palb2 Sec13 Nup85 Rab37 Nup88 Dph3 Nup133 Xrcc4 Drg1 Dph5 Rab3d Dph6 Zc3h15 Rigi St6galnac5 Polb Usp14 Nsmce1 Smc6 Nsmce4a Nop58 Top2b Rab5c Arrb1 Rce1 Cdh2 Ube2c Lipt1 Pyurf Mgat5 Pigs Alppl2 Dad1 Nrn1 Rtn4rl2 Edem2 Xpnpep2 Msln Gpld1 Ube2t Pigv Cop1 Tectb Tecta St6galnac3 Otoa Rtn4rl1 Pigk Ly6g6c Pigg Stt3b Izumo1r Prss41 Kctd7 St6gal1 Ly6g6d Ly6d Ube2b Ganab Rpn2 Ube2a Fbxl20 B3gnt6 Rpn1 Galnt10 Galnt17 Btbd1 Galnt15 Fbxw8 Nod1 Pomk Galnt16 Asb16 Ube2l3 Galnt14 Gcnt1 Pofut2 Ripk2 Herc2 Fbxo21 Gpc3 Ube2r2 Magt1 Uba6 Fbxo7 Sec22b Klhl25 St3gal4 Klhl20 Klhl2 Mgat4a Spsb2 Mgat4b Fbxl14 St3gal1 Nudt14 Spsb1 Fbxl16 Areg Fbxl19 Asb7 Tmem258 Gmppa Dolpp1 Fcsk H2-Q10 Golga2 Rab36 Cog2 Cog6 Bet1l Cog8 Tubb2a Capza1 Fbxw4 Actr10 Vdac3 St3gal6 Rnf146 Otulin Rab7 Rhoa Gne Epas1 Ank1 Man1a Usp10 Rabggta Dcaf13 Rab43 Pcna Kdelr2 Traf2 Tmed9 Ripk1 Usp7 Cdc34 Bard1 Kin Mettl22 Eef2kmt Eef1akmt2 Eef1akmt1 Preb Tgfbr1 Mdm2 Psmd9 Rab11a Psmd10 Pomp Apob Ccna1 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation Ing2 Rbbp7 Meaf6 Akt3 Akt2 Pml Akt1 Pip4k2c Pin1 Gatad2a Hdac1 Ing5 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway Casp3 Tnfrsf10b Fas Traf2 Ripk1 Dcc Tlr4 Ly96 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS Irs2 PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair Msra DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation Mras Camk2g Camk2d Camk2b Ppp2r5e Camk2a Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Map3k11 Phb1 Ppp1cc Map2k2 Map2k1 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors S100a9 Apoa1 Apob Cd5l SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors Apob ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding Cd9 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders Psmb1 Psmc2 Lmbrd1 Erlin2 Psma7 Abcb6 Erlin1 Psmd12 Psmd11 Apoa1 Psma6 Psmd8 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) Fga Myd88 Fgg S100a9 S100a1 Btk Tlr4 Fgb Ly96 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Jun Mapk14 Map3k8 Mef2c Ppp2r5d Btrc Ube2v1 Nod1 Ripk2 Btk Nkiras1 Fgb Nkiras2 Fga Peli1 Myd88 Usp14 Fgg S100a1 Irak1 Traf2 Tlr4 Ly96 Tab2 S100a9 Map2k1 Mapk1 Ecsit RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Serpinb13 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Tfdp1 Men1 Cdkn2b Ccnc Cdk8 Mapk1 Hdac1 Usp9x Smad4 Tfdp2 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation Rpl4 Castor1 Rpl39 Rpl7 Tcirg1 Szt2 Mlst8 Eif2s3x Eif2s2 Rpl22 Rpl18 Atp6v1a Atp6v0d2 Sh3bp4 Atp6v1h Atp6v1f Trib3 Rps25 Rps26 Rps27 Lamtor2 Rps21 Sec13 Samtor Nprl2 Wdr59 Depdc5 Rps11 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling Il25 Jun Irak1 Il17f Mapk14 Il17a Map3k8 Mef2c Ppp2r5d Tab2 Btrc Ube2v1 Nod1 Map2k1 Mapk1 Ripk2 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination Ptrh2 Psmb1 Usp44 Psmc2 Usp37 Usp20 Psma7 Usp25 Wdr20 Usp28 Usp12 Usp19 Stam2 Clspn Usp9x Usp15 Nod1 Ripk2 Rad23a Rad23b Trrap Kdm1b Ruvbl1 Usp22 Yy1 H2bu2 Vdac3 Hcfc1 Birc3 Birc2 Axin2 Rigi Il33 Rnf146 Rhoa H2bc9 H2bc7 Polb Ar H2bc8 Usp10 Usp14 Vdac1 Traf2 Ripk1 Usp7 Otub1 Bard1 Zranb1 Arrb1 Otud5 Rce1 Tgfbr1 Psmd12 Mdm2 Psmd11 Psma6 Ccna1 Psmd8 Smad4 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psmb1 Psmc2 Psma7 Ube2c Fzr1 Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Psmd8 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events Camk4 Ahcyl1 Pde1a Gnai2 Camk2g Camk2d Camk2b Camk2a Plcb4 Camkk2 Prkar2a Prkar1a Mapk1 Prkacb Gna14 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Exosc9 Dcp2 Exosc8 Zfp36 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction Myl6b Cacna1i Tpm3 Cacna1h Myl7 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling H2bu2 Gng3 Gnb2 Akt3 Akt2 Gnb1 Kdm1a Sphk1 Gnb4 Jun Strn Polr2k Cav2 Akt1 Nrip1 Stag2 Smc3 H2bc9 H2bc7 Fkbp4 H2bc8 Kdm4b S1pr3 Mmp7 Ppid Gnai2 Areg Mmp9 H3c7 Ptk2 Pik3r1 Polr2g Tnrc6a Myb H2ax Mapk1 Gtf2f1 Hdac1 Egfr Yy1 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 Gab1 Frs2 Ptpn11 Pik3r1 GSD II%REACTOME%R-HSA-5357609.5 GSD II Gaa TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism Ido2 Afmid EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants Fga Arrb1 Csk Fgg Apbb1ip Rap1a Map2k2 Map2k1 Mapk1 Fgb INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling Arnt2 Arnt RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination Zfp473 Pabpn1 Nudt21 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels Ttyh2 Sgk3 Sgk2 Scnn1b Scnn1g Ano6 Tpcn1 Tpcn2 Clcn6 Tsc22d3 Clcn7 Clcn4 Clcn5 Bsnd Slc9b2 Stom Trpc6 Trpv4 Trpv6 Trpm8 Trpm4 Asic4 Clca1 Clcn2 Clcn3 Clcn1 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions Plxnd1 Plxnb3 Sema7a Plxna1 Sema5a OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) Psmb1 Oaz2 Psmc2 Psma7 Nqo1 Psmd12 Psmd11 Psma6 Psmd8 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) Rhoa ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Polb NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle Gls2 Ppfia2 Aldh5a1 Ppfia4 Lin7c Cplx1 Slc18a3 Gls Maoa RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation Polr2k Ercc3 Rbbp7 Gtf2h2 Gtf2h3 Gtf2h5 Ubtf Taf1d Rrn3 Gatad2a Hdac1 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion Hsd17b10 Ngrn Trmt10c Prorp Elac2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide Ca2 Ca1 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling Casp2 Bex3 Casp3 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants Flt3 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair Fanci Psmb1 Psmc2 Exo1 Ube2t Fancb Fancc Psma7 Dclre1a Rfc5 Fan1 Rfc3 Rtel1 Rfc4 Rfc2 Wrn Clspn Ube2b Rpa2 Rbbp8 Rpa3 Nhej1 Dclre1c Eya3 Apbb1 Tdp2 Poll Rbx1 Herc2 Xpc Ddb1 Kdm4b Parp2 Rad23a Rad23b Rfc1 Pold4 Cops8 Cops7a Cops7b Ppp4c Ruvbl1 Ell Polr2g Eme1 Rchy1 Mus81 Palb2 H2ax Nthl1 Yy1 H2bu2 Polh Xrcc4 Terf2 Mad2l2 Uba7 Rev1 Terf2ip Polr2k Ascc2 Gtf2h2 Prkdc Gtf2h3 Gtf2h5 Parg H2bc9 Pias3 H2bc7 Polb H2bc8 Ercc3 Eya1 Usp10 Xab2 Pcna Polq Usp7 Rad9a Bard1 Isy1 Ascc1 Mgmt Psmd12 Psmd11 Psma6 Ccna1 Psmd8 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Kdr Bin2 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 Psen2 Adam17 Tab2 Gabrb3 Egfr Apoe Itch Pik3r1 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism Ugt8 Cerk Hexb B4galnt1 Arsj Arsi Ctsa St6galnac5 Smpd1 M6pr Asah1 Neu3 Psap B4galt6 A4galt Neu1 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death Psmb1 Psmc2 Ctnnb1 Akt3 Akt2 Psma7 H1f2 H1f3 Sptan1 Dynll1 Clspn C1qbp Akt1 Ube2l3 Itch Casp1 Gzmb Casp3 Gsdme Satb1 Dsp Chmp3 Plec Chmp6 Pkp1 Pdcd6ip Gsdmd Nmt1 Birc3 Birc2 Dcc Tfdp2 Tfdp1 Cdc37 Peli1 Tnfrsf10b Fas Traf2 Dynll2 Ripk1 Tlr4 Ly96 Ptk2 Mapk1 Psmd12 Psmd11 H1-5 Psma6 Psmd8 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Hadha BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling Cbl Sh2b3 Kit SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Casp3 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition Psmb1 Psmc2 Akt3 Akt2 Psma7 Tfdp2 Tfdp1 Ptk6 Akt1 Ccne1 Psmd12 Psmd11 Psma6 Ccna1 Psmd8 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G Psmb1 Psmc2 Psma7 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors Avpr1b DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid Clps Lipf DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species Sod2 Cyba Cybb Gpx7 Atox1 Txnrd1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex Rpa2 Mcm8 Cdc45 Pola2 Rpa3 Gmnn Orc1 Orc2 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Slc35a1 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Pik3r1 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly Apoc2 Apoc3 Apoc1 Prkacb Mttp Apoa1 Apoa2 Apoe Apob Apoa4 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA Zfp473 Pabpn1 Nudt21 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL Hadha HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation Slco1b2 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones Hsd17b14 Stard3nl Stard3 Cyp11b1 Cyp11b2 Akr1b1 Hsd11b1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 Fgf22 Cbl Spred1 Mapk1 Gab1 Spred2 Frs2 Ptpn11 Fgfrl1 Pik3r1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER Ercc3 Rfc1 Pold4 Rfc5 Xab2 Rfc3 Rfc4 Rfc2 Pcna Usp7 Polr2k Polr2g Rpa2 Isy1 Gtf2h2 Rpa3 Gtf2h3 Gtf2h5 Rbx1 Ddb1 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants Tyk2 Foxm1 Jun Hip1 Strn Npm1 Tpm3 Dctn1 Rnf213 Prkar1a Rbx1 Bcl11a Sec31a Icos Myh9 Gzmb Alk Irs1 Frs2 Eef1g Pik3r1 Bcl2a1d Mapk1 Mdm2 Gcc2 Hdac1 Prf1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels Gabbr2 Gng3 Gnb2 Gnb1 Gnb4 Kcnj3 Kcnj10 Kcnj5 Kcnj15 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family Slc39a5 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Ctnnb1 Tcf7l1 Cdkn2a Hdac1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport Trappc4 Sptbn4 Sptb Dync1h1 Rab1b Dctn2 Dynll1 Sptan1 Dync1i2 Dctn1 Csnk1d Ank1 Ins2 Sec31a Sec22b Kdelr2 Tmed9 Dynll2 Areg Trappc10 Golga2 Sec13 Gorasp1 Preb Ppp6c Lman2 Cog2 Sec22c Cog6 Sec23ip Bet1l Cog8 Trappc6b Ankrd28 Capza1 Trappc6a Actr1a Actr10 Cog1 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA H2bu2 Epop Rbbp7 Aebp2 Phf19 H2ax H2bc9 H2bc7 H2bc8 Ezh2 H3c7 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth Prnp Sptbn4 Sptb Cacna1i Cacna1h Gdnf Col4a4 Col6a3 Mapk1 Col4a5 Sptan1 Ptk2 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation Jak1 Tyk2 Map2k2 Map2k1 Mapk1 Ptpn11 Dusp10 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors Rxfp1 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex Mllt3 Ercc3 Ssrp1 Ctr9 Ell Polr2k Polr2g Gtf2h2 Gtf2h3 Aff4 Gtf2h5 Supt6 Gtf2f1 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis Ppt1 Elovl6 Elovl5 Hacd1 Morc2a Fasn Acly Elovl1 Acsl3 Tecr Scd1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends H2bu2 Exo1 Rfc5 Rfc3 Rfc4 Rfc2 Ppp4c Clspn Wrn Rpa2 Rad9a Bard1 Rbbp8 H2ax Rpa3 H2bc9 H2bc7 H2bc8 Herc2 Ccna1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors Ptgir Ltb4r2 Ptger2 Ptger3 Cysltr1 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy Tbk1 Tomm6 Vdac3 Tomm7 Atg5 Ube2v1 Vdac1 Ube2l3 Mfn1 Mfn2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization Kdr Flt4 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells Areg NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency Nags WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Wnt5a Ap2a2 Ap2a1 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination Ada DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) Serp1 Gfpt1 Mbtps1 Syvn1 Yif1a Exosc9 Dcp2 Exosc8 Ern1 Klhdc3 Exosc4 Hsp90b1 Dis3 Eif2s3x Eif2s2 Exosc6 Ppp2r5b Exosc1 Exosc2 Dctn1 Creb3 Dcstamp Creb3l1 Sec31a Preb Cxxc1 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state Psmb1 Psmc2 Arrb1 Psma7 Psmd12 Dzip1 Psmd11 Rbx1 Psma6 Itch Psmd8 Cdon DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 Gne NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways Nup205 Nup133 Nup107 Sec13 Pabpn1 Nup85 Kpna4 Nup88 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle Actn1 Tmod3 Txnl1 Stk38 Cdc37 Cct7 Myo6 Ddx39b TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) Kcnk4 Kcnk2 Kcnk10 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Parp2 Rpa2 Rfc1 Pold4 Rfc5 Rfc3 Rpa3 Rfc4 Rfc2 Parg Pcna Polb DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant F10 F9 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation Mcm8 Orc1 Orc2 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrna9 Chrnb2 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT Cma1 Cbl Sh2b3 Grap Kit Mmp9 Tec Ptpn11 Pik3r1 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome Apobec4 Apobec2 Apobec1 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor Rasgrf2 Camk2a Lrrc7 Camk2g Camk2d Camk2b REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription Kcnip3 Nr3c1 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type Gpc3 Gpc2 Gpc4 Sdc3 Cspg5 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling Jak1 Il15 Il2rb SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins Ing2 Nup133 Xrcc4 Mitf Wrn Npm1 Pml Nrip1 Stag2 Smc3 Pias3 Ar Nr3c1 Herc2 Xpc Vdr Rara Ctbp1 Pcgf2 Nsmce1 Smc6 Satb2 Pcna Nsmce4a Nop58 Top2b Nup205 Nup107 Sec13 Cbx4 Satb1 Bmi1 Mdm2 Hdac1 Nup85 Phc3 Nup88 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes Myd88 Irak1 Ripk2 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol Rpl4 Xrn2 Rpl39 Rpl7 Exosc9 Isg20l2 Nip7 Exosc8 Bysl Riok2 Exosc4 Gnl3 Ebna1bp2 Dis3 Exosc6 Exosc1 Exosc2 Rpl22 Rpl18 Csnk1d Mphosph6 Rps25 Rps26 Noc4l Rps27 Pdcd11 Imp4 Dcaf13 Trmt112 Utp6 Rrp9 Utp14a Nop58 Rpp21 Rps21 Ddx49 Rcl1 Nop10 Rpp14 Utp11 Dkc1 Rpp40 Bms1 Ddx52 Nat10 Wdr75 Rps11 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression Tnrc6a Kcnip3 Nr3c1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) Mdh2 Sdhaf1 Ogdh Lyrm4 Idh3b Trap1 Nnt Sdhc Idh2 Sdhb GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis St6galnac5 Ugt8 Cerk B4galnt1 B4galt6 A4galt FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants Flt3 Cbl DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation Nosip Nmt1 Akt1 Spr NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation Psmb1 Psmc2 Itgav Pdxk Mapk14 Pecam1 Gns Gaa Dera Cfp Ctsa Cfd Slco4c1 Cystm1 Pa2g4 Snap29 Gpi Siglec12 Clec4b2 Enpp4 Asah1 Atp8a1 Crispld2 Dsp Fabp5 Plekho2 Rab37 Hp Ilf2 Atp11b Ptprb Lamp1 Lamp2 Arl8a Rab3d Man2b1 Hexb Slpi Ckap4 Tcirg1 Prcp Sirpb1b Ap2a2 Cant1 Vat1 Pkm Tollip Prg3 Nckap1l Rap2c Ampd3 Bin2 Orm3 Actr2 Abca13 Itgam Cab39 Irag2 Stom Anpep Cd63 Pygb Dpp7 Agl Slc44a2 Pygl Cpne1 Cpne3 Idh1 Cpped1 Rab5c Fth1 Cyba Csnk2b Cybb Rhof Dync1h1 Iqgap2 Ano6 Acly Dynll1 Sptan1 Hpse Cd300a Ctsg Golga7 Pycard Magt1 Mmp9 Pgm2 Mgst1 Serpinb1a Pgm1 Ctsh Psap Actr10 Pkp1 Gsdmd Frk Rab14 C3ar1 Rab7 Rhoa Plau Lrrc7 Serpinb6a Pafah1b2 Lamtor2 Ptprj Rnase2b Prtn3 S100a9 Rab27a Rap1a Mapk1 Psmd12 Neu1 Psmd11 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Ffar1 Gna14 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psmb1 Psmc2 Psma7 Ube2c Anapc11 Anapc10 Psmd12 Anapc1 Psmd11 Psma6 Ccna1 Psmd8 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 Abcb6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants Kit GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly Gjb4 Gja8 Gjc2 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants Flt3 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN Tbk1 Nlrp4e NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus Jag1 Psen2 Mib1 Mib2 Mdk Jag2 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) Slc22a12 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea Myh9 Kcnmb1 Rdx Pjvk Xirp2 Eps8 Sptan1 Kcnn2 Strc Cib2 Cdh23 Chrna9 Myo7a Tprn Ripor2 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression H2bu2 Polr2k H2ax H2bc9 Mybbp1a Taf1d H2bc7 H2bc8 H3c7 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Exo1 Bard1 Rbbp8 Palb2 Wrn MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy Chmp6 Tbk1 Tomm6 Dync1h1 Vdac3 Tomm7 Gabarap Atg5 Mlst8 Dynll1 Dync1i2 Pik3r4 Ube2v1 Epas1 Ube2l3 Atg101 Atg13 Atg3 Atg4a Atg4d Prkag2 Vdac1 Lamtor2 Dynll2 Csnk2b Prkag3 Tsc2 Plin2 Mfn1 Gabarapl2 Chmp3 Mfn2 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors Camk2a Lin7c Grin3b Lrrc7 Camk2g Camk2d Camk2b REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity Camk4 Camk2a Tnrc6a Lbr Hdac1 Camk2g Camk2d Camk2b ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases Serpinb1a Gsdmd Casp3 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 Psmb1 Psmc2 Psma7 Btrc Fzr1 Psmd12 Psmd11 Psma6 Psmd8 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants Alk ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters Slc25a10 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System Fga F12 Myd88 Fgg F2 S100a1 Tlr4 Ly96 Tlr7 Unc93b1 S100a9 Klkb1 Btk Fgb REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity Psmb1 Psmc2 Ppargc1b Msx2 Psma7 Esrra Psmd12 Psmd11 Nr3c1 Rbx1 Psma6 Psmd8 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion Nuf2 Nup133 Dync1h1 Dynll1 Ccnb2 Dync1i2 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Cenpa Wapl Stag2 Smc3 Nsl1 B9d2 Ska1 Rps27 Ahctf1 Taok1 Dynll2 Cenpm Cenpi Nup107 Sec13 Cenpf Kif18a Nudc Kif2c Ppp1cc Nup85 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME Xdh Nme1 Slc28a2 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins Strn MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase Tuba1a Nuf2 Psmb1 Psmc2 Emd Dync1h1 Psma7 Dynll1 Ccnb2 Dync1i2 Cenpa Wapl Stag2 Smc3 Nsl1 B9d2 Rps27 Taok1 Cenpm Lbr Nup205 Cenpi Nup107 Sec13 Cenpf Kif18a Kif2c Ppp1cc Rcc1 Tubb2a Nup85 Chmp3 Tubal3 Chmp6 Nup133 Lemd3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ska1 Ahctf1 Dynll2 Ube2c Nudc Anapc11 Anapc10 Psmd12 Ppp2r2a Anapc1 Psmd11 Psma6 Psmd8 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress Exosc4 Dis3 Exosc6 Exosc1 Exosc2 Exosc9 Dcp2 Exosc8 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation Camk2a Lrrc7 Camk2g Camk2d Camk2b DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Avpr1b IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling Prkacb TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane Akt2 Tbc1d4 C2cd5 Myh9 Prkag2 Aspscr1 Slc2a4 Rab14 Prkag3 Akt1 Rab13 Myo5a Rab11a Exoc7 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex Chmp6 Pik3r4 Chmp3 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants Pik3r1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress Rpa2 Rad9a Mcm8 Rfc5 Cdc45 Rfc3 Rpa3 Rfc4 Orc1 Rfc2 Orc2 Clspn TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Npm1 Pitx2 Kctd1 Kctd15 Mybl2 Kdm5b Kit Egfr Apoe Yy1 Atad2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation Ercc3 Taf7 Taf5 Taf2 Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence H2bu2 H1f2 H1f3 Terf2 Terf2ip Hmga2 H2ax H2bc9 Ccne1 H2bc7 H2bc8 Asf1a H1-5 Ccna1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair Psmb1 Psmc2 Exo1 Psma7 Rfc5 Rfc3 Rtel1 Rfc4 Rfc2 Wrn Clspn Rpa2 Rbbp8 Rpa3 Nhej1 Dclre1c Eya3 Apbb1 Tdp2 Poll Rbx1 Herc2 Ddb1 Kdm4b Parp2 Rfc1 Pold4 Ppp4c Eme1 Mus81 Palb2 H2ax H2bu2 Polh Xrcc4 Prkdc H2bc9 H2bc7 H2bc8 Eya1 Pcna Polq Rad9a Bard1 Psmd12 Psmd11 Psma6 Ccna1 Psmd8 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle Ppfia2 Ppfia4 Cplx1 Maoa PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling Prkar2a Prkar1a Prkacb PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C Ube2c Anapc11 Anapc10 Anapc1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells Pou5f1 Cbfa2t2 Pdpn CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) Psmb1 Psmc2 Psma7 Cd207 Psmd12 Psmd11 Psma6 Psmd8 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism Slco1b2 Hmbs Urod REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2bu2 Rbbp7 H2ax H2bc9 H2bc7 H2bc8 Gatad2a Hdac1 H3c7 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair Rfc5 Rfc3 Rfc4 Rfc2 Polr2k Rpa2 Gtf2h2 Gtf2h3 Rpa3 Gtf2h5 Pias3 Rbx1 Xpc Ddb1 Parp2 Rad23a Ercc3 Rad23b Rfc1 Pold4 Cops8 Xab2 Cops7a Cops7b Pcna Ruvbl1 Usp7 Ell Polr2g Isy1 Yy1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation Fgf7 Fgf22 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription H2bu2 Rbbp7 Ctnnb1 Brd4 Jun Tead3 Tead2 Ezh2 H3c7 Tcf7l1 H2ax Epas1 Tead4 H2bc9 H2bc7 H2bc8 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation F11 F9 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling Gng3 Gnb2 Gnb1 Gper1 Gnb4 Prkar2a Prkar1a Gnaz Gnai2 Prkacb TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis Rfc1 Usp10 Polh Pold4 Rfc5 Rfc3 Rfc4 Rfc2 Pcna Uba7 Rev1 Rpa2 Rpa3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) Pigv Pigg Pyurf TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus Nup205 Nup133 Nup107 Sec13 Nup85 Nup88 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 Gpc3 Gpc2 Gpc4 Sdc3 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Prelid1 Prelid3a DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER Parp2 Rad23a Rad23b Cops8 Cops7a Cops7b Ruvbl1 Rbx1 Xpc Yy1 Ddb1 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA Rpl4 Psmb1 Psmc2 Rpl39 Zfp473 Psma7 Rpl7 Exosc9 Dcp2 Exosc8 Mapk14 Zfp36 Exosc4 Pabpc1 Dis3 Exosc6 Exosc1 Rpl22 Exosc2 Tnfsf13 Akt1 Mphosph6 Ythdc1 Zc3h18 Dxo Trmt10c Prorp Elac2 Etf1 Upf3a Gspt1 Polr2g Nup205 Nup107 Sec13 Gtf2f1 Nup85 Nup88 Nup133 Phf5a Rpl18 Xab2 Sf3b6 Ctnnbl1 Pop7 Trmt112 Pop4 Snrpn Pop1 Rtcb Nop58 Rpp21 Cherp AI597479 Rtraf Rpp14 Rpp40 Hsd17b10 Isy1 Yrdc Mto1 Puf60 Ppil4 Ppil1 Pus3 Trmt10a Rps11 Trmt13 Trmt61a Tprkb Snupn Ctu2 Hnrnpr Sugp1 Nudt21 Srrm2 Csnk1d Prpf6 Ppig Ppih Prpf8 Smg6 Wbp11 Smg5 Rps25 Pqbp1 Adarb1 Rps26 Apobec4 Rps27 Adar Apobec2 Apobec1 Rps21 Gemin2 Ddx20 Hnrnpa1 Xrn2 Pnpt1 Rexo2 Lrpprc Isg20l2 Nip7 Bysl Riok2 Gnl3 Polr2k Ebna1bp2 Gtf2h2 Gtf2h3 Gtf2h5 Pabpn1 Prpf3 Snrnp25 Eif4b Snrnp27 Eif4e Cactin Pnn Ccdc12 Prpf40a Ddx39b Snrpa1 Rbmx2 Dhx38 Thoc1 Hnrnpa2b1 Nsrp1 Ercc3 Thoc3 Snrnp35 Srsf10 U2af1l4 Thoc6 Prpf4b Prpf18 Noc4l Cwf19l2 Snrpc Pdcd11 Trp53rkb Imp4 Prpf38a Dcaf13 Ppil2 Mettl3 Utp6 Rrp9 Steep1 Dhx35 Utp14a Lsm2 Ddx49 Rcl1 Lsm8 Nop10 Ppwd1 Utp11 Dkc1 Bms1 Ddx52 Nat10 Wdr75 Cnot7 Cnot6 Cnot9 Ngrn Ppp2r2a Psmd12 Psmd11 Psma6 Psmd8 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab Cdc37 Erbin GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants Flt3 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm Ctnnb1 Foxa2 Tead4 Tead2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria Akt3 Akt2 Akt1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 Jag1 Psen2 Gzmb Mib1 Mib2 Mamld1 Mdk Jag2 Hes5 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand Rpa2 Pold4 Pola2 Rpa3 Pcna TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids Slc27a1 Slc27a6 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity Syt2 Sv2a RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Polr2k Ercc3 Polr2g Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation Gpc3 Gpc2 Gpc4 Sdc3 Hpse DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d Alg3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation Men1 Msln Ktn1 Mbtps1 Ckap4 Calu Apoe Hsp90b1 Lamb2 Gpc3 Fga Fbn1 Fgg Mgat4a Apoa1 Apoa2 Prss23 Bpifb2 Mxra8 Fam20a Igfbp5 Igfbp4 Ccn1 Cdh2 Vwa1 Apob CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions Cdh11 Cdh24 Ctnnb1 Cdh8 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase Pkp1 Ctnnb1 Casp3 H1f2 H1f3 Birc2 Clspn Sptan1 Ptk2 Satb1 Dsp H1-5 Plec BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression Ncoa6 Bmal2 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling Psmb1 Psmc2 Psma7 Il1r2 Map3k8 Tollip Btrc Ube2v1 Nod1 Ripk2 Rbx1 Nkiras1 Nkiras2 Peli1 Myd88 Usp14 Irak1 Traf2 Tab2 Map2k1 Psmd12 Il1r1 Psmd11 Psma6 Psmd8 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression H2bu2 Ercc3 Sap30 Ubtf Sap30bp Taf1d H3c7 Polr2k H2ax Gtf2h2 Sap30l Gtf2h3 Gtf2h5 Sap130 H2bc9 H2bc7 H2bc8 Hdac1 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins Cdh11 Hoxc8 Tnrc6a Cdh24 Snai1 Ctnnb1 Zc3h12a Cdh8 Cdh19 Ilf3 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers Psmb1 Psmc2 Ctnnb1 Psma7 Mlst8 Camk2g Camk2d Camk2b Psen2 Npm1 Camk2a Mapkap1 Akt1 Prkar1a Rbx1 Fgb Fga Fgg Nf1 Gzmb Spred1 Spred3 Spred2 Polr2g Ppp1cc Gtf2f1 Syvn1 Klb Fgf15 Kit Strn Pik3r5 Clcn6 Ppp2r5e Akt1s1 Ppp2r5d Ppp2r5c Tpm3 Ppp2r5b Ppp2r5a Dctn1 Cdc37 Erbin Phb1 Dkk1 Bin2 Bcr Jag2 Fgfr3 Bcl11a Jag1 Mras Ctbp1 Sec31a Pik3cg Icos Agtrap Alk Irs1 Frs2 Ap3b1 Hhat Pik3r1 Arrb1 Irs2 Bcl2a1d Gcc2 Egfr Prf1 Fzd4 Kdr Fzd6 Rac2 Akt3 Akt2 Erlin2 Zmym2 Tyk2 Foxm1 Kremen1 Hip1 Rnf213 Apbb1ip Zc3hav1 Mib1 Fgfr1op2 Ptpn11 Adam17 Csk Hgf Gab1 Areg Hes5 Eef1g Dusp10 Fgf7 Fgf22 Map3k11 Tsc2 Hdac1 Hdac5 Ccnc Jun Mib2 Mamld1 Flt3 Polr2k Cbl Cdk8 Myh9 Bdnf Tgfbr1 Rap1a Map2k2 Map2k1 Mapk1 Mdm2 Psmd12 Psmd11 Psma6 Smad4 Psmd8 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Gng3 Csnk2b Gnb2 Gnb1 Pdcl Gnb4 Cct7 Gna14 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo Wwc1 Casp3 Lats1 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation Fbn1 Fbln5 Fbn2 Itgav Tgfb2 Mfap5 Loxl1 Loxl3 Eln MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis Glrx5 Hscb Lyrm4 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 Psen2 Adam17 Tab2 Apoe RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression Acacb Fasn Acly REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling Usp14 Traf2 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors Jun Mapk1 Mapk14 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins Psmb1 Psmc2 Psma7 Btrc Cry1 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells Psen2 Epha5 Ephb1 Ephb3 Ephb4 Epha4 Mmp9 Ap2a2 Ap2a1 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Ptgr2 Ptgds Cbr1 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation Hnrnpa2b1 Srsf10 Xrn2 U2af1l4 Hnrnpr Snrpc Sf3b6 Snrpn Sugp1 Cherp Nudt21 Polr2k Polr2g Phf5a Srrm2 Puf60 Pabpn1 Hnrnpa1 Gtf2f1 Snrpa1 Prpf40a HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2bu2 Rbbp7 Nup133 Dync1h1 Ezh2 Dynll1 Dynll2 H3c7 Dync1i2 Nup205 Pml Nup107 Sec13 H2bc9 H2bc7 H2bc8 Nup85 Egfr Nup88 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib Cdc37 Erbin PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions Pecam1 Itgav Ptpn11 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle Gls2 Ppfia2 Ppfia4 Cplx1 Gls DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency Cyp11b2 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation Cd3g PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism Tat SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification Gng3 Gnb2 Gnb1 Gnb4 Gnai2 Gna14 Mapk14 P2ry1 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate Chia Amy2a5 GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation Gabbr2 Gng3 Gnb2 Gnb1 Gnb4 Kcnj3 Kcnj10 Gnai2 Kcnj5 Kcnj15 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD Bckdhb MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling Gga3 Crk Hgf Gab1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription Zfhx3 Smad4 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking Rab38 Trappc4 Trappc11 Tbc1d10b Rab1b Ankrd27 Gabarap Tbc1d24 Rin2 Akt1 Gns Amph Cops8 Tbc1d4 Cops7a Cops7b C2cd5 Aspscr1 Slc2a4 Ubap1 Snap29 Tsg101 Sec13 Vps25 Mvb12a Chmp3 Picalm Chmp6 Ap2a2 Ap2a1 Dctn1 Actr2 Actr3 Cd3g Sec31a Prkag2 Bloc1s1 Bloc1s3 Tbc1d8b Il7r Myo6 Dnajc6 Bloc1s4 Ap1s3 Dynll2 Tpd52l1 Rab5c Ap3b1 Fth1 Sort1 Hip1r Arrb1 Arpc4 Sh3kbp1 Gorasp1 Rab9 Ppp6c Lman2 Sec22c Wnt5a Sec23ip Ankrd28 Gcc2 Egfr Fzd4 Actr1a Cog1 Sptbn4 Akt3 Sptb Akt2 Dync1h1 Dctn2 Stam2 Dynll1 Sptan1 Hip1 Dync1i2 Fnbp1 Synj1 M6pr Rhobtb3 Csnk1d Syt2 Sec22b Areg Cyth4 Tsc2 Golga2 Rab36 Kif18a Cog2 Kif2c Cog6 Eps15 Bet1l Cog8 Klc2 Myo5a Capza1 Gjc2 Actr10 Gjb4 Kif12 Gja8 Racgap1 Kif1c Kif21b Ubqln2 Syt9 Slc18a3 Kifc5b Kif27 Ap1g2 Cbl Rab14 Rab7 Ank1 Man1a Ins2 Bicd2 Myh9 Bicd1 Pafah1b2 Rint1 Use1 Rab43 Vps52 Kdelr2 Tmed9 Naa38 Naa30 Gdi1 Arfip2 Dennd6a Dennd6b Dennd2b Trappc10 Prkag3 Dennd4b Gga3 Preb Dennd2d Rab27a Tbc1d13 Rab11b Trappc6b Rab13 Rab11a Trappc6a Gabarapl2 Apob Exoc7 Trappc8 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins Psmb1 Psmc2 Psma7 Mapk14 Akt1 Rbx1 Maoa Il21r Muc1 Ifnlr1 Il18r1 Crlf2 Il2rb Ptpn2 Il1r2 Il20ra Il33 Ppp2r5d Tollip Il15 Il19 Osmr Il10rb Itgam Nkiras1 Nkiras2 Il25 Rag2 Peli1 Rag1 Myd88 Usp14 Il13ra1 Ebi3 Crlf1 Il7r Irs1 Hspa9 Ca1 Pik3r1 Tec Ptpn20 Csf2ra Irs2 Il1r1 Tbk1 Jak1 Tyk2 Ccl22 Ccl20 Btrc Ptpn13 Ube2v1 Nod1 Ctsg Ripk2 Ptpn11 Casp1 Blnk Casp3 Hgf Irak1 Il17f Mmp9 Il17a Mmp1a Tab2 Il13 Tnf Capza1 Batf Il21 Taldo1 Gsdmd Tnfrsf1a Jun Map3k8 Mef2c Hsp90b1 Cbl Nos2 Il12rb1 Crk Il12rb2 Cfl1 Il12b Pdcd4 Il12a Snrpa1 Sod2 Hnrnpa2b1 Ptpn7 Il34 Traf2 H3c7 Lifr Prtn3 Csf2 Map2k1 Mapk1 Il2 Psmd12 Psmd11 Psma6 Psmd8 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors Pitx2 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects Cdk6 Tfdp1 Ube2c Fzr1 Anapc11 Anapc10 Ccne1 E2f2 Anapc1 E2f3 Tfdp2 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi Man1a REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression H2bu2 Psmb1 Psmc2 Ctnnb1 Erlin2 Psma7 Jak1 Erlin1 Jun Mib2 Stt3b Rpn2 Pdcd1lg2 Rpn1 Btrc Epas1 Tead4 H2bc9 H2bc7 H2bc8 Rbx1 Magt1 Rbbp7 Brd4 Prkag2 Tead3 Tead2 Ezh2 H3c7 Tnrc6a Tmem258 Csnk2b Prkag3 Tcf7l1 H2ax Psmd12 Psmd11 Psma6 Dad1 Psmd8 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation Mrps16 Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mrpl47 Mrpl49 Mrps23 Mrps28 Mrpl52 Mrpl33 Mrpl11 Mrpl34 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling Tyk2 Il12rb1 Il12b MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Rpa2 Exo1 Pold4 Rpa3 Pcna INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling Fga Csk Fgg Apbb1ip Akt1 Rap1a Crk Fgb Ptk2 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation Polr3d Polr2k Polr3f Polr3k Snapc1 Snapc2 Gtf3c2 Gtf3a Brf2 Polr3a NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism Gemin2 Snupn Nup205 Nup133 Ddx20 Nup107 Sec13 Nup85 Nup88 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism Plekha6 Tnfaip8l1 Pik3cg Inpp5f Pitpnb Pi4k2b Pik3c2b Gdpd5 Gdpd1 Mtm1 Mtmr7 Mtmr6 Pik3r5 Mtmr4 Pik3r1 Pik3r4 Synj1 Rab14 Inpp4a Ptpn13 Pip4k2c P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling Adam17 Myd88 Prex1 Bex3 Casp3 Irak1 Rasgrf2 Psen2 Casp2 Rhoa Arhgef15 Arhgef17 Ripk2 Hdac1 Arhgef11 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers Pbrm1 Phf10 Bcl11a TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes Gls2 Akt3 Akt2 Gls Prkag2 G6pdx Lamtor2 Mlst8 Tnrc6a Gpi Cox6a1 Prkag3 Cox6a2 Tsc2 Akt1 Higd1c Txnrd1 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition Pkmyt1 Lcmt1 Fzr1 Foxm1 Ppp2r2a Ccnb2 Ccna1 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals Mt4 Mt2 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle Ktn1 Emd Mcam Iqgap2 Prex1 Lemd3 Diaph3 Pik3r1 Lbr Cdc42ep1 Dock1 Rab7 Map3k11 Erbin Ophn1 Arhgdig PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control Mrps16 Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mrpl47 Mrpl49 Mrps23 Mrps28 Mrpl52 Mrpl33 Mrpl11 Mrpl34 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins Pdcd6ip Syt2 Sv2a Map2k2 Map2k1 Cd9 Txnrd1 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL Psmb1 Psmc2 Dact1 Psma7 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) Htr6 Taar5 Htr1a Apln Ffar1 Ccl22 Ccl20 Galr1 Ccl2 Kel Ackr4 Rxfp1 Cxcl5 Pnoc Fshr Tshr Opn3 Gper1 Npbwr1 Ptger2 Ptger3 Prokr1 Lpar4 Ptgir Lpar3 Gpr35 Lpar2 Lpar1 F2 S1pr3 Xcl1 Grp S1pr2 Ffar3 Gpr37l1 Bdkrb2 Ackr1 Bdkrb1 Cort Chrm5 P2ry13 P2ry2 Gpr55 P2ry1 Tac3 Opn4 Nmb Drd4 Lpar5 Drd5 Cck Ppan Prok1 Nms Psap Ltb4r2 F2rl2 Adra2a C3ar1 Avpr1b Cysltr1 Opn1sw Npy Mchr1 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) Slc35a1 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses Gns NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response Psmb1 Psmc2 Bard1 Psma7 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 Ddb1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants Mras Ppp1cc MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion Adarb1 Adar TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C7 C9 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) Slc29a3 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) Fanci Ing2 Exo1 Meaf6 Fancc Bcl2l14 Rfc5 Gls Rfc3 Rfc4 Rfc2 Prelid1 Dyrk2 Mlst8 Wrn Prelid3a Zfp385a Med8 Npm1 Rpa2 Casp2 Rbbp8 Pml Mapkap1 Ttc5 Rpa3 Hipk1 Pip4k2c E2f7 E2f8 Higd1c Brf2 Pbrm1 Kdm5b Ssb Gpi Kit Tsnax Gtf3c2 Gtf3a Ar Prkcb Nr3c1 Vdr Rara Ints7 Ints2 Ints3 Snapc1 Snapc2 Nabp2 IntS13 Ints11 Rprd2 Mgll Csnk2b Cox6a1 Cox6a2 Lpin1 Dgat2 Egfr Ajuba Cpap Ctr9 Usp9x Nudt21 G6pc1 Lbr H2ax Med23 Sap30l Med24 Cbx4 Plin2 Akap8l Bmi1 Phf20 Morc2a Phc3 Hdac1 Cxxc1 Scd1 Yy1 H2bu2 Hdac5 Gls2 Men1 Maf Sap30 Yeats2 Aebp2 Arnt Ccnc Zfp141 Hcfc1 Med16 Med17 Sap30bp Taf1d G6pdx Kansl2 Mphosph8 Zfp454 Znf382 Mef2c Polr2k Zfp157 Epop Nkx2-5 Elovl5 Zfp398 Setd1b Zfp712 Ncoa6 Twist2 Gtf2h2 Zfp707 Cidec Zfp248 Gtf2h3 Zfp872 Gtf2h5 Sap130 Tead4 Esrrb H2bc9 Zfp740 H2bc7 Zfp184 H2bc8 Zkscan5 Fabp4 Zfp746 Bod1 Foxp3 Tada2a Krba1 Med31 Ins2 Camk4 Ercc3 Ctla4 Rbbp7 Znf2 Ppargc1b Zfp28 Phf19 Znf583 Phlda1 Rybp Cdk8 Pcgf2 Cdk5 Npy Zfp324 Zfp11 Ubtf Satb2 Mybbp1a Psip1 Ucma Gatad2a Tead3 Ezh2 Tead2 H3c7 Zfp605 Atad2 Lifr Zfp791 Agrp Cdkn2b Msx2 Zfp30 Serpinb13 Pvalb Zfp426 Zfp664 Csf2 Il2 Psmd12 Zfp51 Znf551 Psmd11 Psma6 Zfhx3 Psmd8 Smad4 Psmb1 Cdk6 Pck1 Psmc2 Auts2 Tcf3 Ctnnb1 Ldb1 Psma7 Zfp473 Bcdin3d Kcnip3 Xpo5 Mybl2 Znf771 Znf641 Tdrkh Rbm14 Mybl1 Mobp Nrbp1 Dgcr8 Camk2g Apoe Camk2d Mapk14 Camk2b Polr3a Zfp697 Polr3d Camk2a Polr3f Mga Polr3k Tbx5 Pitx2 Zfp560 Zfp445 Akt1 Esrra Zfp202 E2f6 Rbx1 Elac2 Itch Ell Polr2g Taf11 Taf13 Taf12 Gtf2f1 Arnt2 Ssrp1 Taf7 Taf5 Taf2 Ppp2r5c Ang Jag1 Hnf4a Prkag2 Tnrc6a Brd2 Kctd1 Kctd15 Ube2c Fzr1 Anapc11 Anapc10 Cdkn2a Anapc1 Txnrd1 Akt3 Akt2 Tfb2m Ptpn11 Mterf1b Casp1 Irak1 Myb Tcf7l1 Tsc2 Aff4 Ccne1 Supt6 Rrn3 Mllt3 Zfpm1 Gata1 Jun Mamld1 Notch3 Tfdp2 Tfdp1 Pabpn1 Dicer1 Sod2 Trp53rkb Rabggta Tnfrsf10b Pou4f1 Fas Pcna Lamtor2 Pcbp4 Usp7 Perp Rffl Rad9a Bdnf Bard1 Gck Cradd Prkag3 Pidd1 Cnot7 Cnot6 Cnot9 Cdk12 Jmy Mapk1 Mdm2 Pin1 Banp Btg2 Ing5 Ccna1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria Dynll1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling Irs2 Irs1 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation Acsm5 Glyatl3 Glyat Acsm4 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency Bckdk Bckdhb REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Tbk1 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms Cyba Noxa1 Jun Wnt5a Fzd7 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants Flt3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida Zp3 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR Rpa2 Exo1 Pold4 Rpa3 Pcna BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) Cyp2d22 Cyp2c65 Ltc4s MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) Fga Myd88 Fgg S100a9 S100a1 Btk Tlr4 Fgb Ly96 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand Tlr7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Phf10 Bcl11a RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling Dok6 Dok1 Gdnf Irs2 Gab1 Prkacb Frs2 Ptpn11 Pik3r1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins St3gal4 St6galnac3 Muc1 St3gal1 St6gal1 Muc4 B3gnt2 B3gnt6 Galnt10 Galnt17 Galnt15 Galnt16 B4galt6 Galnt14 Gcnt1 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation Kcnq1 Kcne5 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses Jak1 Tyk2 Rbx1 Rigi Ifna16 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria Auh DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 Notch3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization Txk Plcg2 Itk Ahcyl1 Ppp3cb Btk Tec FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA Phlda1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation Hadha Acaa2 Mecr Acot3 Acot9 Acot12 Acbd6 Mcee ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells Psmb1 Psmc2 Psma7 Btrc Psmd12 Nfkbie Rel Psmd11 Prkcb Psma6 Psmd8 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2bu2 Bcdin3d Xpo5 Tdrkh Mybl1 Dgcr8 H3c7 Polr2k Tsnax Polr2g Tnrc6a H2ax H2bc9 H2bc7 H2bc8 Dicer1 Ang Elac2 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI Mboat7 Plaat3 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs Jak1 Mapk1 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction Tpm3 Tmod3 Tnnt3 Tnnt2 Ttn Tmod1 Tnni3 Myl4 Mybpc3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR Pigk Pigs CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport Slc2a12 Slc5a4a Slc5a1 Slc2a4 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling Apoc2 Mbtps1 Apoc3 Mttp Apoa1 Apoa2 Apoe Apob Apoa4 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase Tuba1a Nuf2 Psmb1 Psmc2 Emd Dync1h1 Psma7 Dynll1 Ccnb2 Dync1i2 Cenpa Wapl Stag2 Smc3 Nsl1 B9d2 Rps27 Taok1 Cenpm Lbr Nup205 Cenpi Nup107 Sec13 Cenpf Kif18a Kif2c Ppp1cc Rcc1 Tubb2a Nup85 Chmp3 Tubal3 Chmp6 Nup133 Lemd3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ska1 Ahctf1 Dynll2 Ube2c Nudc Anapc11 Anapc10 Psmd12 Ppp2r2a Anapc1 Psmd11 Psma6 Psmd8 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Rpl4 Rps25 Rpl39 Rps26 Rpl7 Rps27 Rps21 Etf1 Gspt1 Pabpc1 Rpl22 Rpl18 Rps11 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors Apln Ccl22 Ccl20 Ccl2 Galr1 Ackr4 Kel Cxcl5 Rxfp1 Pnoc C3ar1 Gper1 Npbwr1 Avpr1b Prokr1 F2 Xcl1 Grp Npy Gpr37l1 Bdkrb2 Ackr1 Bdkrb1 Cort Tac3 Nmb Cck Prok1 Nms Psap Mchr1 F2rl2 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses Tbk1 Trex1 Nlrc3 Nlrp4e Cgas Trim21 Prkdc SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins Nup133 Pcgf2 Satb2 Nup205 Nup107 Sec13 Cbx4 Satb1 Bmi1 Nup85 Phc3 Hdac1 Nup88 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome P2rx7 Pycard Sugt1 Casp1 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Rbbp7 Ppargc1b Zfp423 Gatad2a Hdac1 Smad4 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Heph Slc40a1 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex Polr2k Ercc3 Polr2g Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT Kit BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction Pde6a Pde6b Gnb1 Rpe65 Nmt1 Retsat Rdh8 Apoe Apoc2 Sdc3 Rcvrn Rdh12 Apoc3 Opn1sw Gpc3 Rdh16f2 Gpc2 Dhrs9 Gpc4 Clps Ppef1 Apoa1 Apoa2 Apoa4 Myo7a Apob DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ Lmbrd1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle Srgap2 Actn1 Senp1 Rab7 Mcam Baiap2l1 Diaph2 Diaph3 Rhof Farp1 Pik3r1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA Hdac1 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation Rbbp7 Ppargc1b Zfp423 Gatad2a Hdac1 Smad4 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases Tuba1a Psmb1 Psmc2 Cdk5rap2 Cep250 Sdccag8 Dync1h1 Psma7 Ajuba Cep78 Mybl2 Pcm1 Dctn2 Cep164 Ssna1 Foxm1 Cpap Tubg1 Dynll1 Ccnb2 E2f3 Alms1 Dync1i2 Cep135 Lcmt1 Cep63 Cep152 Haus4 Haus5 Csnk1d Btrc Rbx1 Cdk11b Pkmyt1 Phlda1 Tubgcp5 Hmmr Cenpf Tubgcp4 Fzr1 Psmd12 Ppp2r2a Psmd11 Nedd1 Psma6 Ccna1 Actr1a Psmd8 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway Mapk1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade Pde6a Pde6b Gnb1 Nmt1 Rcvrn Ppef1 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions Slc7a7 Atp1b1 Slc7a8 Atp1b3 Slc7a11 Ppil2 Spn Slc16a3 L1cam Mmp1a HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis Hmbs Urod HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Kdr Gng3 Gnb2 Ctnnb1 Gnb1 Ramp2 Trpv4 Gnb4 Mlst8 P2ry2 Pkn2 Flt4 Pecam1 Mapkap1 Akt1 Prkar2a Prkar1a Prkacb GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation Ogdh Gnmt CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis Ubqln2 Syt9 Slc18a3 Stam2 Hip1 Ap2a2 Ap2a1 Fnbp1 Cbl Synj1 M6pr Actr2 Actr3 Cd3g Syt2 Amph Cops8 Cops7a Cops7b Il7r Dnajc6 Areg Rab5c Hip1r Arrb1 Sh3kbp1 Arpc4 Wnt5a Eps15 Egfr Fzd4 Apob Picalm TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 Camk4 Mobp Irak1 Dgcr8 Camk2g Camk2d Camk2b Mef2c Bdnf Tnrc6a Camk2a Lbr Pvalb Hdac1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation Prkag3 Prkag2 Mapk14 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System Git1 Gls Cacng3 Camk2g Camk2d Camk2b Glul Tomt Camk2a Kcng2 Prkar2a Prkar1a Akap5 Prkacb Maoa Slitrk5 Slitrk3 Kcnk9 Rtn3 Syt2 Kcnab1 Kcns2 Kcnh6 Kcnc1 Kcnab3 Kcng1 Gnai2 Kcnn2 Kcns3 Chrnb2 Kcnk4 Kcnk2 Kcnk10 Gls2 Ppfia2 Ppfia4 Gng3 Kcnk7 Cplx1 Kcnk6 Gnb2 Gnb1 Syt9 Slc18a3 Gnb4 Kcnmb1 Sharpin Kcnmb4 Kcnn3 Comt Ap2a1 Camkk2 Kcnb1 Prkcb Kcnj5 Gabra4 Glrb Gabbr2 Slitrk6 Camk4 Lin7c Lrrc4b Slitrk2 Grin3b Chrnd Lrrc7 Gabrr1 Glra3 Prkag2 Gabrr3 Gabrr2 Nrgn Kcnj3 Myo6 Kcnj10 Grik5 Gabrb3 Grik4 Kcnj15 Rasgrf2 Chrna9 Aldh5a1 Prkag3 Lrrtm1 Kcnq1 Cacna2d1 Lrrtm3 Cacna1b Mapk1 Dlgap4 Mdm2 Homer1 Nlgn3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse Ptpn22 Cd3g DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 Nthl1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine H2bu2 H2ax H2bc9 H2bc7 Terf2 H2bc8 Terf2ip REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR Psen2 Adam17 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination Fzd6 Znrf3 Rspo1 Lgr5 Lgr6 Fzd4 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions Slc20a1 Slc13a1 Slc12a6 Slc20a2 Slc26a2 Slc4a3 Slc26a9 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors Pck1 Akt3 Akt2 Apoe Eepd1 Cav2 Akt1 Nrip1 Stag2 Smc3 Fkbp4 Kdm4b Adh4 S1pr3 Kdm1b Mmp7 Gnai2 Areg Mmp9 Polr2g Myb H2ax Kdm3a Gtf2f1 Hdac1 Fabp5 Fabp6 Scd1 Yy1 H2bu2 Gng3 Gnb2 Gnb1 Kdm1a Sphk1 Gnb4 Jun Strn Polr2k Apoc2 H2bc9 H2bc7 Fasn H2bc8 Rara Rdh16f2 Crabp1 Dhrs9 Rdh14 Sdr16c5 Ppid H3c7 Pik3r1 Ptk2 Tnrc6a Ugt1a2 Mapk1 Apoc1 Egfr G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events Apln Rgs8 Ccl20 Galr1 Ccl2 Camk2g Camk2d Cxcl5 Camk2b Pnoc Camk2a Tas2r131 Tas2r135 Opn3 Gper1 Gpsm3 Gpsm1 Npbwr1 Prkar2a Ppp1r1b Prkar1a Ptger3 Prkacb Grm8 Lpar3 Lpar2 Lpar1 Rgs22 S1pr3 S1pr2 Gpr37l1 Bdkrb2 Bdkrb1 Cort Rgs17 Gnai2 P2ry13 Tas2r39 Gpr55 Tas2r38 Plcb4 Drd4 Lpar5 Tas1r1 Nms Psap Tas1r3 Gna14 Tas2r16 Tas2r13 Gng3 Gnb2 Tas2r137 Adra2a Tas2r136 Gnb1 Tas2r140 Gnb4 Ahcyl1 Pde1a Tas2r119 Tas2r4 Tas2r7 Tas2r120 Ppp2r5d Camkk2 C3ar1 Tas2r107 Gnaz Opn1sw Tas2r40 Tas2r41 Gabbr2 Camk4 Cdk5 Npy Mapk1 Mchr1 Ppp3cb Gnat2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME Pck1 Adal DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle Cdk6 Tfdp1 Ube2c Fzr1 Anapc11 Anapc10 Ccne1 E2f2 Atrx Anapc1 E2f3 Tfdp2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT H2bu2 Psmb1 Fzd6 Psmc2 Men1 Ctnnb1 Akt2 Psma7 Kremen1 Axin2 Ppp2r5e Frat2 Rnf146 Znrf3 Ppp2r5d Ppp2r5c Rspo1 Dact1 Ppp2r5b Ppp2r5a Lgr5 Akt1 Lgr6 Btrc Dkk1 H2bc9 H2bc7 H2bc8 Rbx1 Ctbp1 Wnt8a Trrap Ruvbl1 H3c7 Csnk2b Tcf7l1 H2ax Wnt5a Psmd12 Psmd11 Hdac1 Psma6 Fzd4 Psmd8 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nek9 Nek6 Ccnb2 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry Psmb1 Psmc2 Akt3 Akt2 Psma7 Tfdp2 Tfdp1 Ptk6 Akt1 Fzr1 Ccne1 Psmd12 Psmd11 Psma6 Ccna1 Psmd8 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Plcg2 Sh3kbp1 Blnk Ahcyl1 Orai2 Stim1 Btk Pik3r1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants Ppp2r5e Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib Slc37a4 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions Slco4c1 Slco1b2 Slco4a1 Slco2b1 Slco1c1 Slc16a2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis Itgav Tgfb2 Wdr1 Ola1 Nhlrc2 Calu Endod1 Lefty2 Mapk14 Sytl4 Clec3b Plcg2 Manf Lgals3bp Apoh Pecam1 Akt1 Prkar2a Prkar1a Orai2 Prkacb Stim1 Tek Angpt4 Dgkb Fgb Fga Ptgir F10 Itpk1 F12 F11 Prkch Fgg F2 Dagla F9 Serpine2 Gnai2 Cfd P2ry1 Dgkk Jaml Dgkz F2rl2 Lamp2 Adra2a Pik3r5 Ppp2r5e Ppp2r5d Smpd1 Ppp2r5c Atp1b1 Ppp2r5b Ppp2r5a Atp1b3 Orm3 Prkcb Itgam Cd63 Flna Igf1 Pik3cg Ptk2 Pik3r1 Mgll Arrb1 L1cam Rac2 Ano6 Ifna16 Actn1 Sdc3 Apbb1ip Epcam Klkb1 Plg Ptpn11 Gpc3 P2rx7 Gpc2 Igf2 Csk Gpc4 Hgf Dock7 Cd9 Mmp1a Myb Atp2b2 Atp2b1 Slc8a1 Kif18a Slc8a2 Kif2c Cd84 Rbsn Psap Hmg20b Maff Klc2 Capza1 Pdpn Hdac1 Gna14 Mpig6b Mfn1 Mfn2 Kif12 Akap1 Gng3 Gnb2 Racgap1 Kif1c Gnb1 Kif21b Kdm1a Zfpm1 Pde10a Zfpm2 Gnb4 Pde11a Kcnmb1 Sh2b3 Kifc5b Pde1a Kcnmb4 Gata1 Kif27 Dock1 Rhoa Nos2 P2rx4 Cyb5r1 Crk Cd244 Spn Cfl1 Cd2 Selp Slc16a3 Serpinb8 Plau Plat Slc7a7 S100a10 Slc7a8 Trpc6 Serpinb6a Slc7a11 Cdk5 Ppil2 Tnfrsf10b Apoa1 H3c7 Prtn3 Rap1a Ttn Mapk1 Apob AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress Rpl4 Cdk6 Hif3a Psmb1 Mink1 Psmc2 Castor1 Serp1 Rpl39 Psma7 Limd1 Rpl7 Map3k5 Yif1a H1f2 H1f3 Cdkn2c Exosc9 Szt2 Dcp2 Mlst8 Ern1 Camk2g Exosc8 Klhdc3 Ppp1r15a Camk2d Mapk14 Camk2b Exosc4 Map4k4 Camk2a Rpa2 Hmga2 Dis3 Exosc6 Exosc1 Rpl22 Gpx7 Exosc2 Dnaja4 Akt1 Rpa3 Sh3bp4 Nrip1 Crtc1 Fkbp4 Higd1c Rbx1 Nup205 Nup107 Palb2 Sec13 Nqo1 Nup85 Nup88 Nup133 Syvn1 Tcirg1 Tkt Akt1s1 Ppp2r5b Dctn1 Crtc3 Rpl18 Atp6v1a Rai1 Atp6v0d2 Atp6v1f Phb2 Ar Nr3c1 Sec31a Idh1 Bag2 Dynll2 Hspa9 Tnrc6a Cyba Csnk2b Cybb Cox6a1 Cox6a2 Ube2c Fzr1 Anapc11 Anapc10 Cdkn2a E2f2 Anapc1 Txnrd1 Actr1a Rps11 Akt3 Akt2 Dync1h1 Ajuba Dctn2 Dynll1 Dync1i2 Btrc Me1 Slc46a1 Chd6 Rps25 Rps26 Trim21 Rps27 Dnaja2 Rps21 Areg H2ax Cbx4 Ccne1 Bmi1 Capza1 Phc3 Cxxc1 Actr10 H2bu2 Taldo1 Arnt Gfpt1 Mbtps1 Dnajc7 Dnajc2 Jun Hspa12b Bag3 Terf2 G6pdx Hspa14 Terf2ip Hspa4l Ccar2 E2f3 Tfdp2 Tfdp1 Mef2c Stap2 Hsp90b1 Ptk6 Eif2s3x Eif2s2 Ncoa6 Atp6v1h Epas1 H2bc9 H2bc7 Creb3 H2bc8 Dcstamp Creb3l1 Sod2 Bach1 Rbbp7 Trib3 Slc7a11 Lamtor2 Apoa1 Ezh2 H3c7 Tlr4 Ly96 Cdkn2b Chac1 Samtor Preb Lonp1 Nprl2 Atox1 H13 Mapk1 Mdm2 Psmd12 Asf1a H1-5 Psmd11 Wdr59 Apob Psma6 Ccna1 Depdc5 Psmd8 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants Flt3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection Grpel1 Ctnnb1 Hnrnpr Elavl2 Stt3b Nrbp1 Mlst8 Sugp1 Camk2g Ctr9 Camk2d Nudt21 Camk2b Pabpc1 Pik3r4 Camk2a Cd300a Srrm2 Rpn2 C1qa Sdc3 Mapkap1 Rpn1 Prpf6 Prpf8 Gpc3 Wbp11 Gpc2 Rtn3 Magt1 Uba6 Gpc4 Pqbp1 Cgas F2 Dnaja2 Eif4g3 Taok1 Mmp9 Polr2g Tmem258 Tsg101 Hnrnpa1 Gtf2f1 H2bu2 Pdcd6ip Nmt1 Uba7 Ap2a2 Ap2a1 Polr2k Phf5a Tyro3 Rpl18 Pabpn1 H2bc9 Eif4e H2bc7 Fasn Cldn1 H2bc8 Snrpa1 Dhx38 Hnrnpa2b1 U2af1l4 Xab2 Sf3b6 Ctnnbl1 Snrpn Mapre3 Bag2 Apoa1 Cherp Ripk1 Tlr4 Kpna4 H3c7 Ly96 Pik3r1 Ly6e Isy1 Puf60 Ppil4 Ppil1 Dad1 Cog1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN Rit2 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress Kdr Gng3 Gnb2 Ctnnb1 Gnb1 Ramp2 Trpv4 Itgav Gnb4 Mlst8 P2ry2 Ptk2 Pkn2 Flt4 Pecam1 Mapkap1 Akt1 Prkar2a Prkar1a Ppp2r2a Prkacb DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology Camk4 Hdac1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F10 F9 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism Rpl4 Rps25 Aimp1 Rpl39 Rps26 Inmt Rpl7 Rps27 Sephs2 Rps21 Eefsec Cbs Rpl22 Iars1 Secisbp2 Rpl18 Gnmt Sepsecs Ahcy Txnrd1 Rps11 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS Bdnf DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages Fgf7 Lama2 Lamb2 Areg CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli P2rx7 Kdr Gng3 Gnb2 Ctnnb1 Gnb1 Ramp2 Cacna1h Trpv4 Itgav Gnb4 Mlst8 P2ry2 Ptk2 Pkn2 Flt4 Pecam1 Mapkap1 Akt1 Prkar2a Prkar1a Ppp2r2a Prkacb POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching Rfc1 Pold4 Rfc5 Rfc3 Pola2 Rfc4 Rfc2 Pcna REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling Tbk1 Tnfrsf1a Sharpin Birc3 Mib2 Birc2 Traf2 Ripk1 Sppl2b Otulin Sppl2a Ube2l3 Tnf FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex Polr2k Ercc3 Polr2g Gtf2h2 Gtf2h3 Gtf2h5 Gtf2f1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion Plxna1 Cfl1 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly H2bu2 H2ax Adnp H2bc9 H2bc7 H2bc8 H3c7 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 Ptk6 Akt3 Akt2 Rhoa Cdc37 Akt1 Erbin Memo1 Gab1 Matk Egfr Pik3r1 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation Tnrc6a ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface Pdzd11 Atox1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) Rdh16f2 Myo7a Dhrs9 Rpe65 Rdh12 Rdh8 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Tfdp1 Pola2 Tfdp2 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes Csnk2b Ccnb2 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions Plcg2 Siglec15 Sirpb1b Btk Pik3r1 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Ercc3 Taf7 Taf5 Taf2 Polr2k Polr2g Gtf2h2 Taf11 Gtf2h3 Gtf2h5 Taf13 Taf12 Gtf2f1 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling Cdc37 Erbin ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway Psmb1 Psmc2 Sptbn4 Sptb Psma7 Jak1 Tyk2 Sptan1 Camk2g Camk2d Camk2b Camk2a Rasgef1a Zdhhc9 Ranbp9 Apbb1ip Golga7 Tek Rbx1 Fgb Ptpn11 Fga Csk Fgg Rasa4 Nf1 Dab2ip Hgf Spred1 Rasal3 Spred3 Areg Spred2 Dusp10 Fgf7 Fgf22 Map3k11 Ppp1cc Il2rb Klb Fgf15 Kit Flt3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Phb1 Mras Lrrc7 Gdnf Ptpn7 Lamtor2 Irs1 Frs2 Pik3r1 Ptk2 Rasgrf2 Abhd17c Abhd17b Arrb1 Csf2ra Rce1 Irs2 Rap1a Map2k2 Csf2 Map2k1 Mapk1 Psmd12 Il2 Psmd11 Egfr Psma6 Psmd8 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway Psmb1 Psmc2 Taldo1 Akt3 Akt2 Psma7 G6pdx Tkt Akt1 Btrc Me1 Rbx1 Bach1 Chd6 Trim21 Slc7a11 Idh1 Areg Csnk2b Palb2 Nqo1 Psmd12 Psmd11 Psma6 Txnrd1 Psmd8 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells Racgap1 Dync1h1 Dctn2 Dynll1 Ctsa Dynll2 Dync1i2 Rab7 Ctsf Dctn1 Kif18a Ctsh Kif2c Klc2 H2-Oa Capza1 Actr1a Actr10 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Nkx2-2 Neurod1 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Csnk1d Cry1 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression H2bu2 Ercc3 Sap30 Ubtf Sap30bp Taf1d H3c7 Polr2k H2ax Gtf2h2 Sap30l Gtf2h3 Gtf2h5 Sap130 H2bc9 H2bc7 H2bc8 Hdac1 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle Csk Rab7 Mtr Nipsnap2 Arhgdig Stom GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation Psmb1 Psmc2 Msgn1 Ctnnb1 Psma7 Dll3 Lhx1 Pax8 Mamld1 Tead2 Snai1 Zic1 Myb Tcf7l1 Pou5f1 Foxa2 Tead4 Psmd12 Epha4 Psmd11 Psma6 Psmd8 Smad4 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport Slc26a2 Slc5a6 Slc5a1 Slc10a6 Slc6a2 Slc6a5 Slc20a2 Emb Slc40a1 Slc35b3 Slc35a1 Slc8b1 Slc22a12 Slc4a3 Slc22a18 Slc2a4 Slco4c1 Heph Slc17a8 Slc27a1 Slc8a1 Slco1b2 Arl2bp Slc8a2 Slc29a3 Slc28a2 Slc27a6 Slc29a4 Slc9a4 Slc9a2 Slc30a3 Slc25a18 Slc9a3 Slc30a2 Slc39a5 Slc25a10 Slco4a1 Slco2b1 Slco1c1 Slc16a2 Slc16a3 Slc47a1 Slc13a5 Slc25a26 Slc26a9 Slc2a12 Slc31a1 Slc20a1 Slc7a7 Slc44a2 Slc7a8 Slc13a1 Slc38a3 Slc7a11 Slc9a1 Slc5a4a Slc35d2 Pdzd11 Slc12a6 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling Git1 Myh10 Epha5 Myh9 Ephb1 Ephb3 Ephb4 Mmp9 Ap2a2 Ptk2 Ap2a1 Psen2 Rhoa Arpc4 Cfl1 Actr2 Epha4 Actr3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation Ttc5 Jmy Mdm2 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Ccne1 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins H2bu2 Psmb1 Pcsk7 Psmc2 Tcf3 Ctnnb1 Psma7 Strap Kdm1a Zmym2 Mphosph8 Mcrip1 Ganab Snai1 Pkm Rpn2 Klf9 Zbtb33 Twist2 Foxp2 Rpn1 H2bc9 H2bc7 H2bc8 Ctbp1 Rbbp7 Ezh2 H3c7 Tnrc6a Tmem258 Csnk2b H2ax Foxa2 Eps15 Mapk1 Psmd12 Mdm2 Psmd11 Hdac1 Banp Psma6 Dad1 Psmd8 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA Nup205 Nup133 Nup107 Sec13 Rcc1 Nup85 Nup88 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) Lbr Sc5d TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 Tfdp1 Mga Rbbp7 Rbbp8 Rybp Pcgf2 E2f6 Bmi1 Phc3 Ezh2 Tfdp2 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling Trpc6 Dcc UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Psmb1 Psmc2 Psma7 Btrc Psmd12 Psmd11 Rbx1 Mapk14 Psma6 Psmd8 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development Camk4 Hdac1 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm Psmb1 Psmc2 Msgn1 Ctnnb1 Psma7 Dll3 Psmd12 Mamld1 Epha4 Psmd11 Psma6 Psmd8 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins Rpl4 Ptrh2 Usp44 Tcf25 Usp37 Usp20 Rpl39 Usp25 Wdr20 Rpl7 Usp28 Usp12 Usp19 Calu Usp15 Rpl22 Nrip1 Stag2 Smc3 Xpc Ddb1 Rad23a Rad23b Ogdh Cops8 Cops7a Cops7b Ttll6 Agbl5 Ttll5 Etf1 Agbl1 Vash1 Gspt1 Vash2 Eif3l Eif3e Agtpbp1 Eif4ebp1 Eif3b Eif3c Arg2 Rnf103 Rnf139 Edem3 Syvn1 Trim13 Uggt1 Uggt2 Il33 Dctn1 Rpl18 Ctbp1 Sec31a Mdh2 Prss23 Mxra8 Fam20a Ly6e Hsd17b10 Igfbp5 Igfbp4 Ccn1 Igfbp6 Vwa1 Dmbt1 Rab2b Rab25 Cog1 Rab17 Alg8 Msra Alg3 ATP6 Ffar1 Ctr9 Dhdds Mrpl33 Tsfm Mrpl11 Mrpl34 Mrpl58 Mrpl37 Mrps31 Mrpl39 Mrps33 Mrpl18 Mrpl19 Chchd1 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps7 Mrpl43 Mrpl21 Mbtps1 Mrpl47 Mrpl49 B4galnt2 Mrps23 Mrps28 Mrpl52 Hsp90b1 Rnf152 Rnf40 Rab14 Rnf144a Pex12 Prkdc Iars1 Folr2 Tmem129 Ins2 Vdac1 Ppa1 Ppa2 Apoa1 Apoa2 Apoa4 Trappc10 Gga3 Rab27a Neu3 Rab11b Trappc6b B4galt6 Rab13 Trappc6a Neu1 Rab38 Trappc4 Rab1b Aimp1 Mitf Arsj Arsi Clspn Apoe B3gnt2 Grp P2ry2 Ctsa Cdx2 Gip Uqcrc2 Dph3 Drg1 Adra2a Dph5 Dph6 Zc3h15 Cpb2 St6galnac5 Polb Ace Cltrn Anpep Igf1 Enpep Ero1b Cpe Cpb1 Inhbc Cpa3 Nsmce1 Trmt112 Smc6 Nsmce4a Idh2 Nop58 Top2b Hspa9 mt-Cytb Cdh2 mt-Nd4 mt-Nd5 mt-Nd6 Ube2t Twnk Ndufb6 Igf2 Gars1 Yars1 Sec22b Sec61a2 Vars1 Farsa Tars1 Areg Eef1g Ctsh Capza1 Actr10 Vdac3 Eif2b4 Eif2s3x Eif2s2 Eif2b1 Rab7 Ank1 Man1a Rabggta Dcaf13 Pcna Usp7 Bard1 Preb Lonp1 Mdm2 Hif3a Ing2 Serp1 Prelid1 Wrn Npm1 Pml Trrap Dcaf10 Ccdc22 Kdm1b Commd4 Neurl2 Nae1 Dcaf4 Ankrd9 Wsb2 Dda1 Ruvbl1 Dcun1d3 Usp22 Apcs Tspan15 Odam Itm2b Nat8 Ktn1 Sorl1 Tspan33 Ckap4 Pias3 Ar Nr3c1 Vdr Rara Senp1 Dynll2 Csnk2b Rab9 Gorasp1 Ppp6c Lman2 Sec22c Sec23ip Ankrd28 Actr1a Tuba1a Sptbn4 Sptb Dync1h1 Dctn2 Stam2 Sptan1 Dynll1 Usp9x Dync1i2 Csnk1d Btrc Lamb2 Ctsg Plg Cma1 Fbn1 Adamts1 Mmp1a H2ax Cbx4 Satb1 Bmi1 Phc3 Hdac1 Yy1 H2bu2 Men1 Nagk Amdhd2 Gfpt1 Renbp Hcfc1 Birc3 Birc2 Axin2 Mgat3 H2bc9 H2bc7 H2bc8 Rbbp7 Pcgf2 Satb2 H3c7 Bpifb2 Otub1 Zranb1 Otud5 Psmd12 Psmd11 Psma6 Psmd8 Smad4 Psmb1 Psmc2 Ctnnb1 Psma7 Pabpc1 Rbx1 Fga F10 Fkrp Slc35a4 Slc35a1 Crppa Fgg F2 Large2 F9 Fktn Muc1 Adamts20 Adamts10 Sema5a Thsd7a Cfp Thbs2 Muc4 Adamtsl5 Thsd4 Nup205 Palb2 Nup107 Sec13 Nup85 Rab37 Nup88 Nup133 Xrcc4 Rab3d Rigi Spg7 Usp14 Rab5c Arrb1 Csf2ra Rce1 Sftpa1 Aars2 Wars2 Ube2c Pars2 Yars2 Ears2 Lipt1 Pyurf Pigs Mgat5 Dad1 Alppl2 Rps11 Nrn1 Rtn4rl2 Tufm Edem2 Xpnpep2 Msln Gpld1 Pigv Cop1 Tectb Tecta St6galnac3 Otoa Rtn4rl1 Pigk Ly6g6c Pigg Stt3b Izumo1r St6gal1 Prss41 Kctd7 Ly6g6d Ly6d Srp9 Srp68 Ube2b Ganab Rpn2 Ube2a Fbxl20 B3gnt6 Rpn1 Galnt10 Btbd1 Galnt17 Galnt15 Nod1 Fbxw8 Pomk Galnt16 Asb16 Ube2l3 Galnt14 Gcnt1 Pofut2 Ripk2 Eif5b Herc2 Sftpd Fbxo21 Gpc3 Ube2r2 Magt1 Uba6 Fbxo7 Rps25 Rps26 Klhl25 St3gal4 Klhl20 Rps27 Klhl2 Mgat4a Spsb2 Mgat4b Fbxl14 St3gal1 Spsb1 Nudt14 Fbxl16 Rps21 Fbxl19 Asb7 Tmem258 Gmppa Rchy1 Dolpp1 Fcsk Mtrf1l H2-Q10 mt-Nd4l Golga2 Rab36 Cog2 Cog6 Bet1l Ccne1 Cog8 Kif13a Tubb2a Myo5a Gna14 Ap3m1 Fbxw4 Tubal3 Gng3 Gnb2 Xrn2 Gnb1 Sphk1 Pdcl Gnb4 Cct7 St3gal6 Ascc2 Rnf146 Otulin Rhoa Gne Epas1 Eif4b Eif4e Usp10 Rab43 Kdelr2 Traf2 Tmed9 Ripk1 Cdc34 Kin Mettl22 Eef2kmt Eef1akmt2 Eef1akmt1 Tgfbr1 Psmd9 Rab11a Psmd10 Pomp Apob Exoc7 Ccna1 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 Psmb1 Psmc2 Maf Ppargc1b Akt3 Akt2 Psma7 Rbm14 Satb2 Ucma Msx2 Twist2 Esrra Akt1 Mapk1 Psmd12 Ar Nr3c1 Rbx1 Psmd11 Psma6 Psmd8 Smad4 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress Psmb1 Psmc2 Taldo1 Akt3 Akt2 Psma7 G6pdx Tkt Stap2 Ptk6 Ncoa6 Gpx7 Akt1 Btrc Me1 Higd1c Rbx1 Sod2 Bach1 Chd6 Trim21 Slc7a11 Idh1 Areg Csnk2b Cyba Cybb Cox6a1 Palb2 Cox6a2 Nqo1 Atox1 H13 Psmd12 Psmd11 Psma6 Txnrd1 Psmd8 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling Ifnlr1 Jak1 Il19 Tyk2 Il10rb Il20ra Ptpn11 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles Psip1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly Gemin2 Snupn Nup205 Nup133 Ddx20 Nup107 Sec13 Nup85 Nup88 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs Tnrc6a FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors F12 F11 F9 Klkb1 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling Il18r1 Il13 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins Adamtsl5 Thsd4 Adamts1 Adamts20 Adamts10 Sema5a Thsd7a Cfp Pofut2 Thbs2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations Atrx REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis Psmb1 Psmc2 Psma7 Psmd12 Psmd11 Psma6 Psmd8 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG Pla2g3 Lpcat4 Crls1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter Polr3d Polr2k Polr3f Polr3k Gtf3c2 Gtf3a Polr3a INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion Ano6 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network Rac2 Akt3 Akt2 Klb Fgf15 Kit Ier3 Phlpp1 Il33 Strn Pik3r5 Flt3 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Akt1 Pip4k2c Ptpn11 Ins2 Myd88 Trib3 Pik3cg Hgf Irak1 Gab1 Irs1 Areg Frs2 Pik3r1 Fgf7 Bdnf Fgf22 Irs2 Mapk1 Egfr PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation Ptk6 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation Rpl4 Rps25 Rpl39 Rps26 Rpl22 Rpl18 Rpl7 Rps27 Rps21 Rps11 KINESINS%REACTOME%R-HSA-983189.5 Kinesins Kif12 Racgap1 Kif1c Kif21b Kif18a Kif2c Kifc5b Kif27 Klc2 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes Bach1 Chd6 Slc7a11 Nqo1 Txnrd1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum Notch3 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R Igf1 Igf2 Trib3 Akt2 Klb Fgf15 Gab1 Irs1 Frs2 Pik3r1 Flt3 Fgf7 Fgf22 Pde3b Pik3r4 Irs2 Ptpn11 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations Acsm5 Cyp2s1 Arnt2 Mtarc1 Arnt Gstt1 Gstk1 Comt Mat2a Ggt1 Cyp7a1 Ugt2a1 Bpnt1 Ugt2a2 Glyatl3 Cyp39a1 Sult4a1 Ugt2b1 Cyp11b1 As3mt Cyp11b2 Dpep1 Sult1e1 Maoa Adh4 Glyat Abhd10 Fmo2 Trmt112 Por Cyp4f40 Mgst3 Ephx1 Gsta5 Slc35d2 Mgst1 Cyp4f14 Cyp2d22 Cyp2c65 Chac1 Oplah Ugt1a2 Mtr Ahcy Podxl2 Ces2h Acsm4 Cyp7b1 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling Psmb1 Psmc2 Psma7 Akt1 Psmd12 Psmd11 Rbx1 Psma6 Psmd8 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC Csnk2b Slc44a2 Chpt1 Lpin1 Stard10 Chkb Phospho1 Abhd3 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival Adam17 Gng3 Gnb2 Gnb1 Gnb4 Myh9 Ahcyl1 Gnai2 Mapk14 Plcg2 Ggt1 Prkar2a Prkar1a Gnaz Cysltr1 Prkacb Dpep1 Cd3g DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta Nkiras2 Tbk1 Atg5 Dhx58 Uba7 Traf2 Ripk1 Rigi Ifna16 Otud5 Pin1 Nkiras1 Itch G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints Psmb1 Psmc2 Cop1 Psma7 Pcbp4 Mapk14 Zfp385a Btrc Ccne1 Psmd12 Phf20 Mdm2 Rbx1 Psmd11 Psma6 Ccna1 Psmd8 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade Pde6a Pde6b Gnb1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint Psmb1 Psmc2 Cop1 Psma7 Pcbp4 Zfp385a Ccne1 Psmd12 Phf20 Mdm2 Psmd11 Psma6 Ccna1 Psmd8 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 Gng3 Gnb2 Gnb1 Gnb4 Gna14 Mapk14 P2ry1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Abcd3 Cyp39a1 Amacr Slc27a5 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy Prkag3 Prkag2 Plin2 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS Cspg5 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation Gabbr2 Gng3 Gnb2 Gnb1 Gabrr1 Gabrr3 Gnb4 Gabrr2 Kcnj3 Kcnj10 Gnai2 Gabrb3 Kcnj15 Kcnj5 Gabra4 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Tbk1 Tlr4 Ptpn11 Ly96 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription Hdac5 Ccnc Cdk8 Mamld1 Hdac1 Rbx1 Hes5 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes Fanci Ercc3 Ssrp1 Fancc Jun Ell Polr2k Polr2g Gtf2h2 Gtf2h3 Gtf2h5 Cdk12 Gtf2f1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors Grik5 Grik4 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex Eif3l Eif2s3x Eif3e Eif2s2 Rps25 Eif3b Rps26 Eif3c Rps27 Rps21 Rps11 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer Ppp2r5e Fzd6 Ctbp1 Ppp2r5d Ctnnb1 Ppp2r5c Ppp2r5b Ppp2r5a Dkk1 Kremen1 Fzd4 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels Gabbr2 Gng3 Gnb2 Gnb1 Gnb4 Kcnj3 Kcnj10 Kcnj5 Kcnj15 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 Psmb1 Psmc2 Ptk6 Psma7 Ccne1 Psmd12 Psmd11 Psma6 Ccna1 Psmd8 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation Rab17 Rab38 Rab1b Rab3d Rabggta Rab43 Rab5c Rab14 Rab7 Rab9 Rab36 Rab27a Rab11b Rab13 Rab11a Rab37 Rab2b Rab25 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade F2 C1qb C1rb Cr2 Cpn1 C7 C9 Cfd Cd46 Cpb2 Cfb C1qc Crp C1qa Colec10 C3ar1 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates Cyp2s1 Cyp2d22 Cyp4f40 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation Rps25 Rps26 Rps27 Rps21 Pabpc1 Eif3l Eif3e Eif2s3x Eif2s2 Eif3b Eif3c Eif4b Eif4e Rps11 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells Ins2 Pdx1 Gck Akt3 Nkx2-2 Akt2 Mafa Neurod1 Foxa2 Akt1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer Fgfr3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease Gab1 Frs2 Fgfr3 Pik3r1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis H2bu2 Terf2 Terf2ip Sun1 Stag3 H2ax Rec8 Smc1b Stag2 H2bc9 Smc3 H2bc7 H2bc8 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ Mapk1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta Gng3 Gnb2 Gnb1 Gnb4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding Htr6 Taar5 Htr1a Ramp2 Sct Apln Wnt10b Galr1 Kel Rxfp1 Pnoc Tas2r131 Tas2r135 Opn3 Gper1 Npbwr1 Ramp1 Ptger2 Ptger3 Prokr1 Grm8 Gipr Lpar4 Ptgir Lpar3 Gpr35 Lpar2 Wnt8a Lpar1 Glp2r F2 S1pr3 Xcl1 Wnt7a Grp S1pr2 Ffar3 Gpr37l1 Bdkrb2 Ackr1 Bdkrb1 Cort Ramp3 Chrm5 P2ry13 P2ry2 Gpr55 P2ry1 Tac3 Gprc6a Opn4 Nmb Lpar5 Cck Ppan Prok1 Nms Ltb4r2 F2rl2 Gip Adra2a Avpr1b Cysltr1 Opn1sw Wnt5a Fzd4 Fzd7 Fzd6 Ffar1 Ccl22 Ccl20 Ccl2 Ackr4 Cxcl5 Fshr Tshr Tas2r39 Tas2r38 Drd4 Drd5 Tas1r1 Tas1r3 Psap Tas2r16 Tas2r13 Gng3 Gnb2 Tas2r137 Tas2r136 Gnb1 Tas2r140 Gnb4 Tas2r119 Tas2r4 Tas2r7 Tas2r120 C3ar1 Tas2r107 Tas2r40 Tas2r41 Gabbr2 Npy Mchr1 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis Slc35d2 Gpc3 Gpc2 Glce Gpc4 Sdc3 Hs6st2 Hs3st2 Ndst3 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation Lbr Emd Lemd3 Ppp2r2a Ccnb2 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking Vps26a Wnt8a Tmed5 Wnt7a Wnt5a Wnt5b Wnt10b ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection Myh9 Wasf3 Wasf2 Ptk2 Abi2 Dock1 Nckap1l Arpc4 Wipf3 Crk Mapk1 Actr2 Myo10 Actr3 Myo5a Was Cd3g Btk DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis Plcg2 Ahcyl1 Cd3g Pik3r1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Cdk6 Cdkn2a GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F10 F2 F9 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones Tph1 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases Sod2 Golga2 Cdk5 Jun SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 Fgf22 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis H2bu2 Rbbp7 Hoxb4 Ajuba Pcgf2 Hoxa2 Jun Hoxb3 Ezh2 Hoxa3 H3c7 Hoxb1 Hoxb2 Polr2k Polr2g Ncoa6 H2ax Cnot6 Cnot9 H2bc9 H2bc7 H2bc8 Yy1 Rara DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade Jun Mapk14 Map3k8 Mef2c Ppp2r5d Btrc Ube2v1 Nod1 Ripk2 Btk Nkiras1 Fgb Nkiras2 Fga Peli1 Myd88 Usp14 Fgg S100a1 Irak1 Traf2 Tlr4 Ly96 Tab2 S100a9 Map2k1 Mapk1 Ecsit INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling Csf2ra Jak1 Il2rb Csf2 Il2 Pik3r1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript Nup205 Nup133 Nup107 Sec13 Eif4e Nup85 Nup88 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions Lama2 Itgav Lamb2 Col18a1 Itgb4 ADIPOGENESIS GENES%WIKIPATHWAYS_20260910%WP447%MUS MUSCULUS Adipogenesis genes Frzb Mbnl1 Cntfr Serpine1 Gata3 Gata4 Rxrg Gata2 Cfd Nr3c1 Lpl Tgfb1 Hif1a Il6 Sp1 Dvl1 Ndn Id3 Cisd1 Pck1 Wnt1 Pck2 Fzd1 Egr2 Lif Nsg1 Rora Igf1 Bmp4 Bmp3 Stat5a Smad3 Wwtr1 Bmp2 Stat5b Bmp1 Lipe Hnf1a Hmga1 Stat6 Plin1 Plin2 Adipoq Epas1 Rara Slc2a4 Scd1 Foxo1 Creb1 Sfrp4 Nr2f1 Ppard Ppara Pparg Ptgis Rbl2 Rbl1 Klf15 Ncor1 Il6st Ncor2 Ucp1 Gadd45b Gadd45a Pnpla3 Cebpd Mef2d Cebpb Cebpa Ncoa2 Ncoa1 Zmpste24 Rb1 Fabp4 Osm Ppargc1a Lpin3 Celf1 Lpin2 Lpin1 Dlk1 Agt Mixl1 Mef2a Klf7 Klf6 Mef2b Mef2c Klf5 Lep Spock1 Stat3 E2f1 Fas Stat2 Stat1 E2f4 Srebf1 Agpat2 Gdf10 Socs1 Ins1 Gh Socs3 Irs1 Nampt Nrip1 Ins2 Irs4 Trib3 Irs2 Ahr Irs3 Ctnnb1 Lifr Tnf Prlr Bscl2 Cyp26b1 Foxc2 Wnt5b Agrp Wnt10b Twist1 Tle3 Ddit3 Nr1h3 Ebf1 Mif Retn Lmna Rxra Cyp26a1 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260910%WP544%MUS MUSCULUS Exercise induced circadian regulation Ppp1r3c Sf3a3 Nckap1 Vapa Ncoa4 Ucp3 Ugp2 Dazap2 H2bc7 Cbx3 Qki Per2 Hspa8 Per1 Klf9 Rbpms Myf6 Tab2 Tubb4a Azin1 Cebpb Psma4 Btg1 Cry1 Cry2 G0s2 Clock Herpud1 Gfra1 Pigf Erc2 Cldn5 Ppp2cb Nr1d2 Nr1d1 H2-DMa Zfr Etv6 Pura Gstp2 Idi1 Sumo1 Dnaja1 Sumo3 Eif4g2 Stbd1 Tob1 Bmal1 Gstm3 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260910%WP4265%MUS MUSCULUS Ethanol metabolism resulting in production of ROS by CYP2E1 Maff Mafg Map2k2 Mapk8 Map2k1 Cyp2e1 Prkcd Nfe2l2 Mafk Sp1 TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP113%MUS MUSCULUS TGF beta signaling pathway Serpine1 Tgfb1 Wnt1 Lif Bmp4 Mapk9 Fkbp1a Mapk3 Smad3 Tgif1 Ifng Nfkb1 Ltbp1 Jak1 Fst Tfe3 Nog Itgb6 Fos Zeb2 Zfp423 Foxh1 Thbs1 Skil Eng Lef1 Ep300 Spp1 Runx3 Runx2 Jun Tgfbr3 Egf Crebbp Smad1 Smad2 Smad4 Zfyve9 Smad9 Bambi Inhba Tgfbr1 Smad5 Tgfbr2 Smad6 Smad7 Hras Stat3 Stat1 Ctnnb1 Tnf WNT SIGNALING%WIKIPATHWAYS_20260910%WP403%MUS MUSCULUS Wnt signaling Dvl1 Wnt1 Fzd1 Prkcd Mapk9 Sfrp4 Jun Prkd1 Pafah1b1 Rhoa Wnt5a Myc Rac1 Fzd10 Wnt10a Prkcq Gsk3b Prkcg Prkch Prkci Prkcb Prkce Axin1 Ldlr Prkca Csnk1e Fbxw2 Wnt16 Wnt11 Ppp2r5c Wnt6 Wnt7b Wnt3a Dvl2 Dvl3 Wnt7a Wnt2 Prkcz Wnt4 Wnt3 Fosl1 Fzd3 Ccnd2 Fzd2 Ccnd3 Ctnnb1 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Ppp2r5e Plau Wnt10b Apc Frat1 Mapk10 MRNA PROCESSING%WIKIPATHWAYS_20260910%WP310%MUS MUSCULUS mRNA processing Rpl38 Rpl8 Rpl39 Rpl9 Rpl7 Znf830 Rpl32 Abcb4 U2surp Lsm11 Vmn1r26 Trmt2a Clp1 Rpl26 Snrpb2 Trmt1l Rpl22 Snu13 Fdx2 Raly Cfb Dcaf1 Rad21 Snrpa1 Bard1 Mettl3 Ptbp1 Cpeb1 Cpeb3 Cpeb4 Rpl39l Eif4a3 Rnpc3 Eif4a2 Mcts2 Wdr55 Scaf8 Pabpc1 Pabpc2 Nelfe Tmed10 Zfp638 Csad Srp68 Pabpc4 Pabpc5 Pabpc6 Stau1 Rbm12b1 Rbm12b2 Slbp Zfp740 Srp9 Dazl Tert Rbm8a Tut1 Nip7 Gatc Rpl19 Sf3a1 Sf3a2 Rpl11 Rpl12 Dazap1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Dnajc17 Sf3b5 Sf3b6 Akap17b Srp54 Adat1 Atxn1 Fmr1 Rnpepl1 Msi1 Msi2 Alyref2 Rbm31y Hnrnpa2b1 Supt5h Rps9 Rps7 Rnmt Snrnp70 Rps6 Ilf3 Ncl Hnrnpdl Spop Zcrb1 Virma Htatsf1 Tmem163 Oasl2 Snrnp40 Prpf18 Eftud2 Snrpf Snrpe Snrpg Snrpb Snrpa Snrpc Snrpn Alyref Ppp1r14b Ggcx G3bp1 Smn1 Elmod3 Mrpl23 Tia1 Col4a3 Fus Cnot4 Lsm2 Lsm4 Secisbp2 Lsm1 Cdk9 Son Lsm7 Lsm8 Safb2 Eral1 Synj2 Aco1 Sbno1 Hnrnpab Ilkap Mrpl11 Traf6 Rnpep Clasrp Srsf1 Ptbp3 Ptbp2 Ddx19b Srsf9 Srsf7 Ddx19a Srsf6 Srsf5 Adam5 Srsf4 Dis3 Srsf3 Srsf2 Ankar Srek1 Eif4h Tsn Eif4e Snrnp35 Hnrnpa3 Pcolce Sart3 Puf60 Wbp4 U2af1 Ppil4 Eif3g Eif3b Mrm3 Hnrnpa1 Hnrnpa0 Zfp385a U2af2 Bicc1 Cstf2t Ciz1 Ssb Celf6 Celf5 Celf4 Celf3 Celf2 Eif2d Pabpn1 Pskh1 Ro60 Sfswap Mak16 Park7 Ppm1g Dicer1 Slc25a4 Rngtt Smc1a Enox1 Enox2 Rps14 Rnps1 Ltv1 Rps11 Rps13 Rbfox1 Myef2 Rbfox2 Prpf40a Prpf40b Cirbp Uhmk1 Cdc40 Ddx39a Hnrnpll Esrp2 Pcbp2 Imp3 Pcbp1 Ddx39b Pcbp4 Esrp1 Pcbp3 Imp4 Xrn2 Alkbh8 Hnrnpr Dhx8 Dhx9 Hnrnpu Rbms1 Rbm11 Rbms3 Rbm10 Rbms2 Rbm12 Fxr1 Oas1g Fxr2 Oas1b Oas1a Dhx38 Dnd1 Elavl4 Elavl2 Adarb2 Elavl3 Elavl1 Tial1 Rps27 Rps28 Aimp1 Rps29 Rps20 Pum2 Pum3 Sugp1 Rps23 Sugp2 Pum1 Rps24 Srpk1 Zrsr2 Hnrnpc Hnrnpd Hnrnpf Hnrnpk Hnrnpl Srpk2 Hnrnpm Adad1 Cstf1 Nudt21 Prmt1 Auh Sltm Prmt2 Dhx16 Cstf2 Cstf3 Dhx15 Rsrc2 Rnasel Akap1 Slc6a8 Csde1 Rbpms2 Srsf11 Srsf12 Srsf10 Srrm1 Boll Prpf4b Slu7 Tlr5 Raver1 Nol8 Rae1 Npm1 Bclaf1 Ppargc1b Ergic2 Tardbp Znf346 Brca1 Rnaset2b Hnrnph2 Hnrnph1 Prpf4 Prpf6 Rbmxl2 Rbmxl1 Pspc1 Prpf3 Zmat4 Zmat2 Rdm1 Fbl Ppie Tarbp2 Syncrip Zbp1 Rbmx2 Matr3 Mrps28 Rbm4b Prpf8 D1Pas1 Brwd1 Papolg Ppp1r8 Nono Papolb Papola Grsf1 Nop9 Clk1 Clk2 Clk3 Clk4 Ralyl Cpsf4 Cpsf7 Srp14 Cpsf1 Cpsf2 Cpsf3 Ddx1 Tdrd7 Ddx4 Ddx5 Srp19 Ddx6 Eif4e2 Slirp Ybx1 Rbm33 Dnajc8 Dis3l2 Rbm34 Taf15 Rbm26 Rbm3 Ddx3x Rbm4 Nufip1 Rbm25 Rbm28 Sfpq Lingo1 Ddx56 Rbm7 Rbm5 Rbm6 Ewsr1 Txnl4a Adar Naa38 Rbm22 Rbm14 Rbm17 Rbm19 Oas2 Rbm18 Ankrd33b Oas3 Ddx41 Spen Nifk Polr2a Polr2g Poldip3 Eif4g3 Rpp14 Trim21 Nxf1 Rbm47 Ncbp2 Cyp4f3 Rbmy Cd2bp2 Rbmx Nxf7 Rps4x Snrpd2 Tnrc6c Snrpd1 Tra2b Acin1 Rbm42 Rbm41 Rbm43 Snrpd3 Rbm45 Rbm39 Rbm38 Ttc14 Znf622 Eif4e3 Ddx25 Naa12 Rnaseh2a Ddx24 Ddx21 Ddx20 Ttc39a Mbnl1 Ppargc1a Celf1 Eif4g2 Sf3a3 Qki Rbpms Afg3l2 Afg3l1 Phf5a Igf2bp3 Rbm15b Igf2bp1 Eif2ak2 Rpl37 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260910%WP318%MUS MUSCULUS Eicosanoid synthesis Tbxas1 Alox8 Alox5ap Pla2g2a Alox12 Alox5 Dpep1 Lta4h Alox15 Ptges Ptgds Ptges2 Ptgis Pnpla8 Ptgs1 Ggt1 Pla2g6 Ptgs2 Ltc4s OXIDATIVE STRESS AND REDOX PATHWAY%WIKIPATHWAYS_20260910%WP4466%MUS MUSCULUS Oxidative stress and redox pathway Cd44 Ggt5 Ggt7 Ggt6 Gss Idh1 Idh2 Gsr Anpep Sod3 Sod2 Sod1 Cyba Cybb Keap1 Oplah Nfe2l2 Alox5 Ptgs1 Ggt1 Ptgs2 Ncf1 Ncf2 Ncf4 Slco1a1 G6pd2 Gls Gstk1 Txnrd1 Grxcr2 Txnrd3 Txnrd2 Grxcr1 Gsto1 Mgst3 Gsto2 Mgst2 Rac1 Mgst1 Prdx2 Slc6a5 Prdx3 Gpx2 Prdx4 Gpx1 Prdx5 Gpx4 Gpx3 Slc6a9 Hpgds Gpx6 Gpx5 Prdx1 Gpx8 Gpx7 Pgd Abcc2 Abcc5 Gstp1 Gstt2 Gstt3 Gstt1 Foxp3 Lap3 Gsta3 Gsta4 Gsta1 Gsta2 Ctla4 Nrf1 Slc7a11 Txn Slco2a1 Gstm7 Gstm5 Gstm6 Ggct Gstm4 Gclc Gstm1 Gstp2 Gstm2 Cbs G6pdx Slc1a2 Slc1a5 Prdx6b Prdx6 Gclm S100a9 Gstm3 S100a8 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP539%MUS MUSCULUS Wnt signaling pathway Dvl1 Mapk1 Map3k7 Pias4 Sox1 Cdh1 Wnt1 Myb Akt1 Fzd1 Sox9 Tax1bp3 Cxxc4 Skp1 Ppp2ca Daam1 Dkk1 Magi3 Axin2 Smad3 Ror2 Crybb2 Btrc Sall1 Raf1 Cdc25c Senp2 Vangl2 Ruvbl1 Nlk Dab2 Tfap2a Jup Fzd4 Bcl9 Dlg1 Dlg2 Dlg4 Cul1 Cdk1 Pin1 Tcf4 Tcf3 Csnk2a2 Fhl2 Csnk2a1 Mark2 Ctbp1 Ctbp2 Sfrp2 Sfrp1 Csnk2b Tbp Pax2 Csnk1d Lrp1 Lrp6 Csnk1a1 Lrp5 Camk2g Nkd1 Camk2d Camk2b Camk2a Arrb2 Arrb1 Brd7 Map1b Ctnnbip1 Ankrd6 Mapk8ip1 Frat2 Hipk2 Nr5a1 Sumo1 Mapk8 Mapk9 Mapk3 Lef1 Ep300 Runx2 Jun Smad4 Rhoa Wnt5a Rac1 Gsk3b Prkcb Axin1 Prkca Csnk1e Wnt3a Dvl2 Dvl3 Wnt7a Wnt2 Wnt4 Wnt3 Fzd2 Ctnnb1 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Apc Frat1 BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260910%WP3663%MUS MUSCULUS BMP signaling pathway in eyelid development Inhbb Smad5 Foxc2 Jun Tgfa Pitx2 Fgf10 Dkk2 Smad1 Egfr Fgfr2 Smad4 Bmp4 Shh Mapk9 Map3k1 Sfrp1 Foxc1 Mapk3 Notch1 ELECTRON TRANSPORT CHAIN%WIKIPATHWAYS_20260910%WP295%MUS MUSCULUS Electron transport chain Ucp1 Sdhd Sdhc Sdhb Sdha Cox7a2l Cox6a1 Cox6a2 Uqcrfs1 Sco1 Uqcrq Coxfa4 ATP6 Atp5f1e Atp5f1d Atp5f1c mt-Atp8 Atp5mf Atp5me Cox8a Cox6b1 Ndufv2 Dmac2l Atp5mg Ndufv1 Surf1 Atp5f1b Cox15 Ndufv3 Atp5f1a Uqcrb Cox17 mt-Co2 mt-Co3 mt-Cytb Uqcrh mt-Nd4 mt-Nd5 Ucp3 mt-Nd6 Ndufab1 Ndufc1 mt-Co1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa12 Ndufa10 Cox7b Ndufs1 Slc25a27 Ndufs3 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Slc25a14 Cox6c Ndufa1 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Cox7a1 Cox7a2 Atp5po Ucp2 Cox5a Cox5b Ndufb2 Ndufb4 Uqcrc2 Ndufb3 Ndufb6 Uqcrc1 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Atp5if1 Uqcr10 Uqcr11 Slc25a5 Slc25a4 MISMATCH REPAIR%WIKIPATHWAYS_20260910%WP1257%MUS MUSCULUS Mismatch repair Pold1 Pcna Lig1 Msh2 Rfc1 Exo1 Rpa1 Mlh1 Msh6 GPCRS NON ODORANT %WIKIPATHWAYS_20260910%WP1396%MUS MUSCULUS GPCRs non odorant Fzd4 Adora2b Adora2a Ednrb Ednra Rrh Htr4 Ptgdr Trhr Htr6 Htr7 Oprd1 C3ar1 Gpr174 Galr2 Galr1 Sstr5 Avpr2 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp2 Rxfp1 Htr5b Rxfp4 Htr5a Ghrhr Tbxa2r Fpr1 Nmbr Ccr10 Vipr2 Vipr1 Ptgfr Tas2r16 Tas2r13 Agtr1a Agtr1b Tas2r137 Ccr1 Adgrb1 Lpar6 Oxtr Adgrb2 Xcr1 Adgrb3 Lpar5 Npy6r Gpr18 Grpr Gpr15 Gpr17 Tas2r140 Cckar Npbwr1 Gpbar1 Nmur2 Gnrhr Nmur1 Ntsr2 Tas2r4 Ntsr1 Ptger4 Tas2r7 Mc2r Ptger2 Gabbr1 Ptger3 Fshr Ptger1 Gabbr2 Ccr9 Ccr8 Mchr1 Ccr6 Fzd1 Crhr2 Ccr4 Crhr1 Ccr3 Ccr2 Mtnr1a Gpr132 Gipr Cckbr Mtnr1b Adgrl2 Adgrl3 Agtr2 Adgrl4 Adgrl1 Calcrl Mc1r Pth1r Rgr Taar1 Gprc5b Gpr143 Gprc5a Gcgr Kiss1r Sctr Gprc5d Mc4r Ptafr Npffr2 Pth2r Gprc6a Cysltr2 Cysltr1 Gpr6 Npsr1 Mc3r P2ry10 P2ry13 P2ry12 P2ry14 Mas1 Gpr50 F2rl1 Tas2r40 Tas2r41 F2rl2 F2rl3 Adra2a Prokr2 Ghsr Adra2c Hcar2 Prokr1 Adra2b Adgrg1 Adgrg2 Cxcr1 Cxcr2 Npy1r Cxcr3 Gpr65 Gpr68 Cxcr4 Cxcr5 Cxcr6 Adrb2 Adrb1 Adra1b Adra1a Adrb3 Adra1d Lhcgr Smo Mc5r Tacr1 Oprm1 Tacr3 Tacr2 Calcr Casr C5ar2 C5ar1 F2r Ffar3 Ffar4 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Chrm1 Hrh1 Chrm3 Chrm2 Hrh4 Chrm5 Chrm4 Hrh2 Hrh3 Drd1 Celsr3 Drd2 Drd3 Celsr1 Drd4 Drd5 Celsr2 Opn4 Opn3 Ccrl2 Gper1 Adcyap1r1 Oxgr1 Opn5 Gpr119 Adora1 Adora3 Ltb4r2 Tas2r119 Prlhr Npy5r Tmigd3 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Tas2r110 Lpar4 Ltb4r Lpar3 Lpar2 Lpar1 Npy4r Cx3cr1 Qrfpr Ptgir Htr1d Htr1f Glp1r Htr1b Htr1a Tas2r123 Adgre4 Adgre5 Adgre1 Tshr Glp2r P2ry6 P2ry4 P2ry2 P2ry1 S1pr1 Hcrtr2 Hcrtr1 S1pr3 S1pr2 S1pr5 S1pr4 Tas2r105 Ackr3 Npy2r Ackr1 Cnr1 Ackr2 Cnr2 Uts2r Ccr1l1 Oprk1 Mrgprd Tas2r103 Fzd3 Fzd2 Fzd5 Fzd7 Fzd6 Fzd9 Fzd8 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260910%WP458%MUS MUSCULUS Inflammatory response pathway Zap70 Fn1 Il2ra Il2rb Il2 Tnfrsf1b Il4 Vtn Tnfrsf1a Il5 Lamb2 Cd40lg Cd28 Lamb1 Cd86 Col1a2 Col3a1 Cd40 Col1a1 Cd80 Lama5 Il2rg Lck Il4ra Il5ra Ifng Lamc1 Lamc2 Thbs3 Thbs1 MIRNAS AND TFS IN IPS CELL GENERATION%WIKIPATHWAYS_20260910%WP2375%MUS MUSCULUS miRNAs and TFs in iPS Cell Generation Sf3a3 Prpf4 Sox2 Pou5f1 Phf5a Ddx39b Snrpa CELL CYCLE%WIKIPATHWAYS_20260910%WP190%MUS MUSCULUS Cell cycle Mcm3 Bub1b Mcm4 Mcm5 Mcm6 Cdc25b Mcm2 Cdc25a Chek1 Chek2 Orc5 Orc4 Tgfb1 Orc6 Prkdc Orc1 Orc3 Orc2 Abl1 Bub3 Cdc45 Cdh1 Mpeg1 Bub1 Cdc14b Cdc14a Plk1 Trp53 Pttg1 Cdc7 Cdc6 Mad1l1 Wee1 Smad3 Cdk6 Cdk4 Cdk2 Mdm2 E2f2 Tbc1d8 Cdc25c E2f3 Atm Cdkn1a E2f5 Cdkn1b E2f6 Atr Smc1b Ep300 Cdk1 Rbl1 Smad4 Gadd45a Pcna Rb1 Gsk3b E2f1 E2f4 Ccna1 Ccna2 Mcm7 Ccne1 Ccnd2 Ccne2 Dbf4 Ccnd3 Ywhag Hdac3 Hdac2 Hdac5 Hdac4 Hdac1 Cdkn2a Hdac7 Tfdp1 Skp2 Hdac6 Pkmyt1 Cdc20 Ccnb2 Ccnb3 Mad2l2 Ccnb1 Ccnh Espl1 Mad2l1 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260910%WP1560%MUS MUSCULUS MicroRNAs in cardiomyocyte hypertrophy Cdk9 Gata4 Tgfb1 Dvl1 Mapk1 Akt1 Fzd1 Map2k2 Mapk8 Lif Map2k1 Igf1 Mapk3 Nfkb1 Raf1 Ikbkb Pla2g2a Rcan1 Mapk7 Ikbkg Fgf2 Ikbke Plcb2 Mapk4 Pdpk1 Akt2 Nfatc4 Egf Hdac9 Edn1 Nrg1 Pik3r1 Il6st Pik3r2 Mylk3 Pik3r3 Map2k7 Mtor Map2k6 Calm1 Map2k5 Lrp6 Eif2b5 Pik3cg Lrp5 Pik3cb Pik3cd Rhoa Ppp3ca Wnt5a Camk2d Mapk14 Pik3ca Rac1 Ppp3cb Prkg1 Mylk Myef2 Map2k4 Gsk3b Map2k3 Nppb Agt Cdk7 Nppa Prkcb Rock2 Chuk Rock1 Cish Tab1 Igf1r Ctf1 Map3k14 Fgfr2 Stat3 Wnt3a Fzd2 Ctnnb1 Tnf Hdac5 Hdac4 Hdac7 NA K ATPASE SRC SIGNALING%WIKIPATHWAYS_20260910%WP5051%MUS MUSCULUS Na K ATPase Src signaling Bcar1 Pak1 Pdgfrb Pdgfra Pak6 Fyn Pak3 Pak2 Pak5 Pak4 Mapk12 Atp1b1 Casp9 Bad Cav3 Casp3 Mapk1 Cav2 Tnk2 Tesk2 Cav1 Tnk1 Ptk6 Akt1 Pten Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Styk1 Bcl2 Grb2 Mapk9 Raf1 Mapk7 Mapk4 Jun Akt2 Pik3r1 Pik3r2 Mtor Map2k6 Map2k5 Pik3cg Hras Pik3cb Pik3cd Pik3ca Rac1 Gsk3b Map2k3 Igf1r Egfr Flt1 Erbb2 Birc3 Ilk Birc2 Braf Elk1 Mapk6 Crkl Akt3 Rac2 Kdr Rac3 Rap1a Rap1b Ccnd2 Selenop Cycs Ccnd3 Ctnnb1 Cyct Xiap Ccnd1 Araf Vav1 Fgr Hck Apaf1 Pik3r5 Crk Met Sos1 Pik3r4 Blk Srms Shc3 Shc1 Atp1a1 Src Txk Dock1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260910%WP6%MUS MUSCULUS Integrin mediated cell adhesion Mapk1 Akt1 Raf1 Mapk7 Mapk4 Pdpk1 Akt2 Pik3r2 Map2k6 Map2k5 Map2k3 Rock2 Rock1 Ilk Braf Mapk6 Akt3 Rac2 Rac3 Rap1a Rap1b Selenop Araf Crk Sos1 Shc3 Shc1 Src Dock1 Bcar1 Pak1 Pak6 Fyn Pak3 Pak2 Pak4 Mapk12 Cav3 Cav2 Cav1 Map2k2 Ptk2 Map2k1 Rapgef1 Grb2 Tns1 Mylk2 Sorbs1 Tln1 Vcl Vasp Arhgef7 Pxn Itga7 Itga8 Itga5 Itga6 Itga9 Itgb6 Itga3 Itga4 Itga1 Itga2 Capn9 Itga10 Itga11 Capn5 Capn7 Capn6 Capn1 Capn3 Capn2 Itgax Itgav Itgam Itgae Itgal Vav3 Itgad Itgb8 Itgb7 Vav2 Itgb1 Itga2b Itgb4 Itgb5 Itgb2 Actn1 Hras Itgb3 Rho Csk Cdc42 Git2 Rac1 Zyx Capns1 Capn10 Capn11 Mapk10 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP450%MUS MUSCULUS IL 2 signaling pathway Fyn Nr3c1 Mapk1 Akt1 Map2k2 Mapk8 Map2k1 Bcl2 Grb2 Mapk9 Stat5a Mapk3 Eif4e Nfkb1 Stat5b Jak1 Raf1 Eif3b Creb1 Tert Pik3r1 Pik3r2 Mtor Pik3cg Pik3cb Pik3cd Mapk14 Il2ra Pik3ca Il2rb Il2 Ets1 Shb Ets2 Plcb1 Hsp90aa1 Jak3 Chuk Foxo3 Jak2 Cish Stam2 Syk Gab2 Rack1 Rela Stat3 Ifna1 Icam1 Il2rg Lck Cd53 Socs1 Ptpn6 Stat1 Itm2b Stam Socs3 Cbl Irs1 Ybx1 Crkl Rps6kb1 Ptpn11 Prkcz Kras Lyn Mapkapk2 Ptk2b Irs2 Nmi Mknk1 Vav1 Crk Sos1 Shc1 IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP93%MUS MUSCULUS IL 4 signaling pathway Fyn Bad Mapk1 Akt1 Ptk2 Prkcd Grb2 Stat5a Mapk3 Nfkb1 Jak1 Hmga1 Stat6 Ep300 Crebbp Pik3r1 Ncf1 Pik3r2 Pik3cd Mapk14 Pik3ca Il4 Ets1 Prkci Jak3 Cxcr4 Jak2 Rela Il2rg Lck Socs1 Ptpn6 Il4ra Stat1 Elk1 Stam Socs3 Cbl Irs1 Rps6kb1 Ptpn11 Prkcz Irs2 Atf2 Spi1 Prkd3 Pawr Socs5 Il13ra1 Tyk2 Bcl2l1 Plcg1 Dok2 Inpp5d Sos1 Rasa1 Grk3 Fes Mapk11 Shc1 Src FATTY ACID OXIDATION%WIKIPATHWAYS_20260910%WP2318%MUS MUSCULUS Fatty acid oxidation Acadm Cpt2 Acads Hadh Acadvl Echs1 Acaa2 Cpt1a Mttp Slc25a29 ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP435%MUS MUSCULUS One carbon metabolism Mthfd1l Mtr Ahcyl2 Dhfr Bhmt Shmt2 Dnmt3a Mtfmt Shmt1 Mat2b Gart Folh1 Ahcy Mtrr Tyms Amt Dnmt3b Mthfd1 Mthfd2 Ftcd Dnmt1 Atic Tcn2 Ehmt2 Aldh1l1 Mat1a Ehmt1 Mthfs Mthfr ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP252%MUS MUSCULUS Androgen receptor signaling pathway Cdc25b Nr3c1 Il6 Sp1 Mapk1 Prmt1 Pias4 Akt1 Trp53 Igf1 Smad3 Nr2c2 Pias3 Mdm2 Uxt Ctdp1 Raf1 Kat5 Ube2i Kat7 Gtf2f2 Gtf2f1 Pias1 Pias2 Tle5 Patz1 Flna Cdc37 Pa2g4 Brca1 Ranbp9 Senp1 Ube3a Cdk1 Rad54l2 Ar Bag1 Hmgb2 Gtf2h1 Fhl2 Psmc3ip Esr1 Esr2 Il6st Mmp1a Ncor2 Sin3a Ywhah Ghr Pou2f1 Rnf14 Calr Pou2f2 Nr0b2 Nr0b1 Ncoa2 Plagl1 Ncoa1 Spdef Etv5 Rb1 Svil Tmf1 Hspa1a Rnf4 Appl1 Ncoa3 Nsd1 Pnrc1 Cdk7 Sry Runx1 Casp8 Casp7 Casp1 Nr5a1 Stub1 Tgfb1i1 Rchy1 Ran Egfr Hipk3 Stat3 Rac3 Src Cdk9 Ncoa4 Pak6 Casp3 Cav1 Pten Map2k1 Tgif1 Pxn Cox5b Ep300 Runx2 Jun Crebbp Smad4 Slc25a4 Rela Nrip1 Ccne1 Atf2 Ctnnb1 Ccnd1 Hdac1 Ccnh BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260910%WP522%MUS MUSCULUS Biogenic amine synthesis Pnmt Hdc Asmt Gad1 Gad2 Dbh Comt Th Pah Chat Aanat Ache Tph1 Maoa Ddc MACROPHAGE MARKERS%WIKIPATHWAYS_20260910%WP2271%MUS MUSCULUS Macrophage markers Cd68 F3 Rac2 Cd86 Cd74 Cd52 Lyz2 Cd163 Cd83 Cd14 MIR 1 IN CARDIAC DEVELOPMENT%WIKIPATHWAYS_20260910%WP608%MUS MUSCULUS miR 1 in cardiac development Irx5 Hand2 Kcnd2 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260910%WP2928%MUS MUSCULUS miR 222 in exercise induced cardiac growth Hipk2 Hmbox1 Hipk1 Cdkn1b G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP298%MUS MUSCULUS G13 signaling pathway Ppp1cb Rtkn Calm1 Diaph1 Cfl1 Cfl2 Wasl Pak3 Pik3cb Rhpn2 Pik3cd Sh3rf1 Rhoa Cit Cdc42 Myl1 Pik3ca Limk1 Rac1 Mybph Pkn1 Pfn1 Pip4k2a Tnk2 Rock2 Rock1 Rps6kb1 Gna13 Mapk10 Arhgef1 Sra1 Was Arhgdib Map3k4 Pik3r2 Arhgdig Iqgap1 Iqgap2 OXYLIPINS PATHWAYS%WIKIPATHWAYS_20260910%WP5140%MUS MUSCULUS Oxylipins pathways Tbxas1 Alox8 Alox12 Fads2 Alox5 Cbr1 Dpep1 Prxl2b Lta4h Gpx1 Hpgd Alox15 Ptges Fads1 Ptgds Ephx2 Ptgis Hpgds Ggt1 Ptgs2 Ltc4s ALPHA 6 BETA 4 INTEGRIN SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP488%MUS MUSCULUS Alpha 6 beta 4 integrin signaling pathway Pak1 Rtkn Fyn Bad Casp3 Abl1 Clca1 Clca2 Akt1 Rpsa Ptk2 Ywhae Ywhab Erbin Prkcd Plec Grb2 Dsp Mmp7 Dst Cd151 Smad3 Lama1 Eif4e Lama2 Lama3 Trp73 Mst1r Ywhaz Col17a1 Eif4ebp1 Itga6 Cdkn1a Ntn1 Lamb3 Sfn Yes1 Eif6 Vim Ar Smad2 Pik3r1 Pik3r2 Ywhah Pik3r3 Mtor Itgb4 Pik3cg Pik3cb Pik3cd Rhoa Pik3ca Rac1 Lamb2 Lamb1 Prkca Egfr Erbb2 Lama5 Lamc1 Lamc2 Irs1 Irs2 Met Shc1 Src FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260910%WP3675%MUS MUSCULUS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling Mtor Itgb1 Ppargc1a Tnfrsf1a Akt1 Pten Igf1r Igf1 Ilk Smad3 Nfkb1 Irs1 Rps6kb1 Jkamp Tnf Pld1 Foxo1 Igfbp3 Igfbp2 Igfbp5 Igfbp4 Igfbp1 Pdk1 Mstn Igfbp7 Igfbp6 Tnfsf9 Smad2 Trim63 Prkab1 Acvr2b NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260910%WP431%MUS MUSCULUS Nuclear receptors in lipid metabolism and toxicity Abcd2 Cyp27b1 Abcd3 Cyp2b10 Cyp4b1 Rarb Cyp8b1 Abcb4 Rarg Vdr Nr1h4 Abcg1 Abca1 Abcc3 Cyp24a1 Abcg5 Cyp1a2 Cyp7a1 Abcb11 Cyp2e1 Abcc2 Rara Ppard Ppara Pparg Nr1h3 Nr1i3 Nr1i2 Abcb1a Cyp26a1 TRANSLATION FACTORS%WIKIPATHWAYS_20260910%WP307%MUS MUSCULUS Translation factors Eif4g3 Eif4h Eif4e Eif4a2 Pabpc1 Pabpc2 Eif4ebp1 Eif3g Eif3b Eif6 Eif2b5 Eef1a2 Eef1d Eef1a1 Eef1g Eif2ak1 Eif2ak3 Eef1b Eif1a Eif5a Paip1 Eif4b Eif3j1 Etf1 Eif3i Eif4ebp2 Eif3f Eif3e Eif4g1 Eif3h Eif4ebp3 Eif3a Eif3d Eif3c Eif2b3 Eif2b2 Eif2b4 Eif2s2 Eif2s1 Eef2k Eif2b1 Eef2 Eif1 Eif5 Eif4a1 Eif2s3x Eif2s3y Eif4g2 Eif2ak2 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260910%WP1250%MUS MUSCULUS Arachidonate epoxygenase epoxide hydrolase Cox8a Ephx2 Cox5a GPCRS PEPTIDE%WIKIPATHWAYS_20260910%WP234%MUS MUSCULUS GPCRs peptide Cckar Gnrhr Ntsr2 Ntsr1 Mc2r Npy5r Fshr Ccr9 Ccr8 Ccr6 Ccr4 Ccr3 Ccr2 Cckbr Npy4r Agtr2 Cx3cr1 Mc1r Tshr Mc4r Mc3r Npy2r Ccr1l1 Oprk1 Ghsr Ednrb Ednra Trhr Cxcr2 Npy1r Cxcr3 Oprd1 C3ar1 Cxcr4 Galr2 Cxcr5 Galr1 Cxcr6 Sstr5 Avpr2 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Lhcgr Avpr1a Mc5r Tacr1 Oprm1 Tacr3 Tacr2 Fpr1 C5ar1 Nmbr Ccr10 Bdkrb2 Bdkrb1 Agtr1a Agtr1b Ccr1 Oxtr Brs3 Fpr-s1 Oprl1 Ccr5 Galr3 Npy6r Grpr ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260910%WP2075%MUS MUSCULUS Alzheimer 39 s disease Atp2a1 Cacna1d Atp2a3 Atp2a2 Apbb1 Ide Adam17 Ryr3 Hsd17b10 Cacna1s Adam10 Lpl Nos1 Mapt Casp9 Bace1 Bad Mme Chp1 Casp3 Mapk1 Chp2 Cdk5r1 Ern1 Psenen Psen1 Fadd Psen2 Atf6 Snca Grin2a Trp53 Ncstn Aph1a Ppp3r2 Ppp3r1 Calm4 Mapk3 Calm2 Gnaq Calml3 Nae1 Bid Grin1 Casp12 Ppp3cc Cdk5 Il1b Apoe Grin2d Itpr3 Grin2c Itpr2 Grin2b Itpr1 Plcb2 Capn1 Capn2 Lrp1 Ppp3ca Ppp3cb Gsk3b Tnfrsf1a Plcb1 Casp8 Casp7 Eif2ak3 Fas Tnf Apaf1 Plcb4 App Plcb3 Cacna1f Cacna1c FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP336%MUS MUSCULUS Fatty acid biosynthesis Acacb Acaca Hadh Scd1 Pecr Mecr Pcx Ech1 Echdc3 Echdc1 Echdc2 Decr1 Acly Acss2 Acsl1 Echs1 Fasn Acaa2 Acsl5 Acsl6 Acsl3 Acsl4 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP1249%MUS MUSCULUS EPO receptor signaling Epo Epor Ptpru Pik3cg Ptprc Mapk1 Akt1 Jak2 Map2k2 Cish Map2k1 Stat3 Grb2 Stat5a Socs1 Mapk3 Stat1 Stat5b Irs1 Raf1 Irs2 Pdk1 Rasa1 Sos1 Shc1 Src G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260910%WP413%MUS MUSCULUS G1 to S cell cycle control Mcm3 Mcm4 Mcm5 Mcm6 Mcm2 Cdc25a Orc5 Orc4 Orc6 Orc1 Orc3 Orc2 Cdc45 Trp53 Wee1 Cdk6 Cdk4 Cdk2 Mdm2 E2f2 E2f3 Atm Cdkn1a E2f5 Cdkn1b E2f6 Cdk1 Rbl1 Gadd45a Pcna Mnat1 Rpa1 Tfdp2 Cdkn2b Rb1 Cdkn2c Myc Cdkn2d Prim2 Prim1 Pole2 Pola2 Ccng2 Rpa2 Cdk7 Rpa3 Cdkn1c Pole E2f1 E2f4 Ccna1 Mcm7 Ccne1 Ccnd2 Ccne2 Ccnd3 Ccnd1 Cdkn2a Tfdp1 Pkmyt1 Ccnh NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2074%MUS MUSCULUS Neural crest differentiation Dvl1 Cdh1 Wnt1 Myb Sox9 Bmp4 Axin2 Tfap2a Fgf2 Tcf4 Hdac9 Ctbp2 Neurog1 Mitf Cdh7 Cdh6 Fgf8 Cdh2 Mpz Sox5 Fgfr2 Mia Msx2 Msx3 Hoxb1 Notch1 Isl1 Foxd3 Prtg Olig3 Olig2 Olig1 Phox2b Dlx5 Gfap Tfap2b Hdac11 Hdac10 Id1 Mbp Tcf7l1 Sox10 Snai2 Snai1 Rbpj Fgfr3 Bmp7 Fgfr1 Lhx1 Lhx2 Gjb1 Tlx2 Lhx5 Fgf15 Rhob Hey2 Zic1 Nfkb2 Hdac8 Ascl1 Dmbx1 Hand1 Pax3 Notch4 Dct Pax7 Notch2 Notch3 Wnt8a Col11a2 Hoxa1 Dll1 Dll3 Dll4 Gbx2 Hes1 Hes5 Col2a1 Pmp22 Zic5 Tbx6 Nfkb1 Smad1 Itgb1 Ets1 Gsk3b Axin1 Wnt3a Dvl2 Dvl3 Fzd3 Ctnnb1 Hdac3 Hdac2 Hdac5 Hdac4 Hdac1 Hdac7 Twist1 Hdac6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260910%WP509%MUS MUSCULUS Nuclear Receptors Rarb Nr0b1 Rxrg Rarg Vdr Nr3c1 Nr5a1 Nr2e1 Hnf4a Esrra Esrrb Rora Nr2f6 Thrb Thra Nr2f2 Rorc Nr1h2 Nr2c2 Rxrb Ror1 Pgr Nr5a2 Nr4a2 Nr4a1 Rara Nr1d2 Nr2f1 Ppard Ppara Ar Pparg Nr1h3 Esr1 Esr2 Nr1i3 Nr1i2 Rxra GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260910%WP164%MUS MUSCULUS Glutathione metabolism Ggt5 Gstt2 Gstt1 Gss Idh1 Gsr Chac2 Gsta1 Anpep Gstm7 Oplah Gpx2 Dpep1 Gpx1 Ggct Gpx4 Gclc Gpx3 Gstm2 G6pdx Ggt1 Gclm HEME BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP18%MUS MUSCULUS Heme biosynthesis Ppox Alad Alas1 Alas2 Hmbs Fech Cpox Uros Urod NOVEL JUN DMP1 PATHWAY%WIKIPATHWAYS_20260910%WP3654%MUS MUSCULUS Novel Jun Dmp1 pathway Hras Rb1 Myc Ets1 Mapk1 Ets2 Map2k2 Map2k1 Trp53 E2f1 Mapk3 Braf Cdk4 Mdm2 Raf1 Kras Fos Ccnd1 Araf Arf1 Dmp1 Cdkn2a Nras Rras Jun Junb FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260910%WP33%MUS MUSCULUS Fatty acid omega oxidation Adh4 Aldh1a1 Adh1 Cyp2e1 Aldh2 Cyp1a1 Adh7 Cyp1a2 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260910%WP108%MUS MUSCULUS Selenium metabolism selenoproteins Pou2f1 Eefsec Sp3 Crem Txnrd1 Scly Sars2 Txnrd3 Selenoh Txnrd2 Selenoi Sars1 Sepsecs Selenok Fabp1 Selenom Selenon Selenoo Sp1 Dio1 Selenos Gpx2 Selenot Dio2 Gpx1 Dio3 Selenov Gpx4 Selenow Gpx3 Sephs2 Sephs1 Cth Gpx6 Trnau1ap Pstk Nfe2l2 Rela Nfkb1 Fos Selenop Jun Selenbp2 Selenbp1 Msrb1 Secisbp2 Rpl30 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260910%WP1248%MUS MUSCULUS Oxidative phosphorylation mt-Nd4 mt-Nd5 mt-Nd6 Ndufc1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa10 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Atp5mc3 Atp5mc2 Ndufa3 Ndufa2 Ndufa5 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufb2 Ndufb6 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Ndufa11 Coxfa4l2 Atp5mc1 Atp6ap2 Atp6ap1 Gzmb Ndufb8 Coxfa4 ATP6 Atp5f1e Atp5f1d mt-Atp8 Atp5mf Atp5me Ndufv2 Dmac2l Atp5mg Ndufv1 Atp5f1b Ndufv3 Atp5f1a ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260910%WP175%MUS MUSCULUS Acetylcholine synthesis Pcyt1a Pdha1 Pdha2 Pemt Chka Chat Ache ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260910%WP240%MUS MUSCULUS Alanine and aspartate metabolism Gad1 Gad2 Crat Adsl Got1 Got2 Gpt Abat Ass1 Carns1 Asl Aspa Agxt Dars1 Pcx BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260910%WP460%MUS MUSCULUS Blood clotting cascade F9 Serpinf2 F13b Serpine1 Serpinb2 Fgb Fga F8a1 Plau F10 Vwf F12 Fgg F11 Plat Plg F2 F5 F7 F8 LIPIDS MEASURED IN LIVER METASTASIS FROM BREAST CANCER%WIKIPATHWAYS_20260910%WP4627%MUS MUSCULUS Lipids measured in liver metastasis from breast cancer Lrat GPCRS ODORANT%WIKIPATHWAYS_20260910%WP1397%MUS MUSCULUS GPCRs odorant Adgrg5 Hcar1 Adgrg6 Gpr165 Gpr162 Adgrg7 Gpr160 Gpr161 Adgrg3 Mrgpra6 Tpra1 Tas2r39 Or5p52 Tas2r38 Gpr61 Gpr63 Mrgpra1 Or10d3 Wls Mrgpra4 Gpr176 Gpr173 Gpr171 Slc52a2 Or8g17 Vmn2r1 Or7e178 Cmklr1 Gpr179 Cmklr2 Or4c3d Or8u9 Or5g25 Or5g26 Gpr75 Or5ap2 Adgra2 Gpr183 Gpr180 Tas1r2 Or2a7 Tas1r1 Or5g9 Gpr107 Or10n1 Or10d1b Gpr101 Tas1r3 Or9s13 Or10p22 Or5p76 Or10h28 Gpr88 Gpr87 Gpr108 Gpr84 Gpr83 Or5p4 Gpr85 Tas2r135 Tas2r134 Gpr82 Or7d11 Tas2r136 Or5ar1 Or5b21 Or6b9 Gpr19 Or2b6 Or5p58 Or5p57 Or2c1 Mrgprb8 Gpr12 Mrgprb1 Tas2r143 Mrgprb2 Adgra3 Mrgprb3 Mrgprb4 Mrgprb5 Tas2r117 Tas2r116 Opn1sw Or8a1b Gpr26 Or5h19 Gpr25 Or5h17 Or5h18 Gpr27 Gpr22 Gpr21 Or5j3 Or1j1 Gpr20 Tas2r113 Or3a10 Tas2r114 Tas2r129 Or7a40 Adgrd1 Gpr139 Gpr137 Gpr135 Or5p79 Gpr37 ADGRF3 Gpr33 Taar6 Or2y1b Gpr35 Taar9 Gpr34 Taar3 Tas2r120 Or5p80 Taar2 Taar5 Gpr31 Taar4 Tas2r124 V1ra8 Tas2r125 Gpr142 Gpr141 Opn1mw Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Or1e16 Mrgprx1 Taar7e Ptgdr2 Or5t7 Or5t9 Adgrf4 Gpr153 Gpr137b Tas2r106 Adgrf5 Gpr137c Vmn1r48 Tas2r107 Gpr152 Vmn1r46 Gpr150 Vmn1r47 Gpr37l1 Adgrf1 Tas2r109 Adgrf2 Or8b8 Vmn1r45 Or5t17 Vmn1r42 Or5t15 Vmn1r43 Gpr4 Gpr3 Or8b3 Gpr157 Gpr158 Ackr5 Gpr155 Gpr156 Gphr Or5m5 Mrgprh Lgr4 Lgr5 Lgr6 Tas2r102 Or4b13 Mrgpre Tas2r104 Mrgprf Or1m1 Mrgprg Rho Brs3 Oprl1 FOCAL ADHESION%WIKIPATHWAYS_20260910%WP85%MUS MUSCULUS Focal adhesion Mapk1 Akt1 Igf1 Raf1 Flna Mapk7 Mapk4 Pdpk1 Akt2 Pik3r1 Pik3r2 Map2k6 Map2k5 Pik3cg Pik3cb Pik3cd Pik3ca Mylk Map2k3 Rock2 Rock1 Egfr Flt1 Erbb2 Birc3 Ilk Birc2 Braf Elk1 Mapk6 Crkl Akt3 Rac2 Rac3 Rap1a Rap1b Selenop Araf Vav1 Fgr Hck Pik3r5 Crk Met Sos1 Pik3r4 Blk Srms Shc3 Shc1 Rhob Src Txk Dock1 Bcar1 Pak1 Pdgfrb Diaph1 Pdgfra Pak6 Fyn Pak3 Pak2 Pak5 Pak4 Mapk12 Col11a2 Bad Cav3 Cav2 Tnk2 Tesk2 Cav1 Col2a1 Tnk1 Ptk6 Pten Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Styk1 Bcl2 Grb2 Mapk9 Mylk2 Tln1 Lama1 Vcl Lama2 Vasp Lama3 Pxn Itga7 Itga8 Itga5 Itga6 Itga9 Itgb6 Itga3 Lamb3 Itga4 Itga2 Thbs1 Itga10 Itga11 Spp1 Capn1 Jun Itgax Itgav Egf Itgam Itgae Tnc Itgal Ppp1r12a Tnn Itgad Tnr Itgb8 Tnxb Itgb7 Col5a2 Col5a3 Itgb1 Hgf Itga2b Col5a1 Itgb4 Pgf Itgb5 Actb Itgb2 Arhgap5 Actn1 Myl6 Itgb3 Reln Lama4 Rhoa Thbs2 Fn1 Cdc42 Thbs4 Pdgfc Rac1 Zyx Pdgfd Chad Pdgfa Vtn Pdgfb Gsk3b Actg1 Col4a4 Col4a1 Lamb2 Col4a2 Col4a6 Ibsp Lamb1 Parvb Col1a2 Pelo Col3a1 Col11a1 Vegfa Col1a1 Vegfd Vegfc Lama5 Vegfb Col6a2 Farp2 Lamc3 Pip5k1c Lamc1 Lamc2 Thbs3 Ccnd2 Ccnd3 Ccnd1 Vwf TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260910%WP1253%MUS MUSCULUS Type II interferon signaling IFNG Cybb Jak2 Prkcd Icam1 Stat2 Socs1 Stat1 Cxcl10 Ifng Socs3 Cxcl9 Gbp2b Ifnb1 Ptpn11 Jak1 Ifngr2 H4c14 Ifngr1 Reg1 Il1b Psmb9 Nos2 Tap1 Spi1 Ciita Irf4 Irf1 Irf2 Irf8 Isg15 Irf9 Ifit2 Eif2ak2 COMPLEMENT ACTIVATION CLASSICAL PATHWAY%WIKIPATHWAYS_20260910%WP200%MUS MUSCULUS Complement activation classical pathway C6 C7 C9 Cd55 C1qc C1qb C1qa C1ra Masp1 C8b C8a C2 C4b C3 C4a C5 C1s1 REGULATION OF PGC1A EXPRESSION BY A GSK3B TFEB SIGNALING AXIS IN SKELETAL MUSCLE%WIKIPATHWAYS_20260910%WP4763%MUS MUSCULUS Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle Tfeb Ppargc1a Gsk3b G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260910%WP232%MUS MUSCULUS G protein signaling pathways Pde7b Pde7a Adcy3 Akap7 Adcy4 Akap8 Adcy1 Akap5 Adcy2 Akap6 Adcy7 Akap3 Adcy8 Akap4 Adcy5 Adcy6 Gnaz Adcy9 Akap10 Akap11 Akap12 Prkcd Akap1 Akap9 Akap13 Pde4a Pde4b Prkaca Prkacb Gnaq Pde8a Pde8b Kcnj3 Gnai2 Gnai1 Gnai3 Ppp3cc Gna12 Gna11 Gng10 Gna15 Gna14 Prkar1a Prkar1b Gnao1 Gng3 Itpr1 Gnal Gng5 Gng4 Nras Pde4c Rras Gng7 Pde4d Gnas Gng8 Slc9a1 Gngt1 Gngt2 Prkar2a Prkar2b Pde1b Pde1c Gnb2 Pde1a Gnb1 Calm1 Gnb3 Gnb5 Gng11 Gng12 Hras Prkd1 Gng13 Rhoa Ppp3ca Prkcq Prkcg Prkch Prkci Prkcb Prkce Prkca Prkcz Kras Prkd3 Gna13 Arhgef1 Plcb3 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260910%WP1243%MUS MUSCULUS EBV LMP1 signaling Nfkb1 Ifnb1 Irak1 Pdlim7 Map3k3 Ccl20 Tradd Traf6 Ccl5 Ikbkb Traf1 Tnf Mapk1 Ikbkg Map3k7 Hsp90aa1 Chuk Mapk8 Map3k14 Rela Nfkb2 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260910%WP201%MUS MUSCULUS Ptf1a related regulatory pathway Pdx1 Hes1 Prox1 Nkx6-1 Rbpj Ptf1a Fgf10 Ctnnb1 Kat2b Rbpjl Notch1 DEREGULATION OF RENIN ANGIOTENSIN SYSTEM BY SARS COV INFECTION%WIKIPATHWAYS_20260910%WP4965%MUS MUSCULUS Deregulation of renin angiotensin system by SARS CoV infection Agtr2 Ace2 Ace Agtr1a SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260910%WP2141%MUS MUSCULUS Serotonin and anxiety Ppp3ca Fos Camk2b Htr1a Eef2 Fmr1 Grm1 Prkcb Plek Plcd4 Pomc Arc Htr2a Gabra1 Htr2c Adra1a Crh Trpv1 DELTA NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP265%MUS MUSCULUS Delta Notch signaling pathway Ascl1 Cntfr Spen Notch4 Adam17 Notch2 Notch3 Adam10 Dll1 Dll4 Mapk1 Hes1 Hes5 Psenen Psen1 Akt1 Psen2 Trp53 Skp1 Ncstn Mapk3 Smad3 Cdk2 Lef1 Ep300 Cul1 Jun Tcf3 Egf Smad1 Ncor1 Pik3r1 Smad4 Pik3r2 Ncor2 Sin3a Gsk3b Jak2 Mef2c Egfr Rela Stat3 Fhl1 Hivep3 Lck Mfng Notch1 Hey1 Numb Ccn3 Cntf Sap30 Hes6 Tle1 Maml3 Zfpm1 Numbl Fbxw7 Pofut1 Aph1b Dtx1 Hdac2 Itch Maml1 Maml2 Hdac1 Ring1 Furin Rbpj Jag2 Jag1 Skp2 Cirsr Nfkbia Magea1 Cntn1 Yy1 Snw1 Lfng App Wdr12 Hey2 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260910%WP3592%MUS MUSCULUS ApoE and miR 146 in inflammation and atherosclerosis Irak1 Apoe Rela Spi1 Traf6 Tlr4 Tlr2 Nfkb2 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260910%WP396%MUS MUSCULUS ACE inhibitor pathway Ren2 Nos3 Agt Agtr2 Kng1 Ace Bdkrb2 Ren1 Agtr1a TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260910%WP1245%MUS MUSCULUS Transcriptional activation by Nfe2l2 in response to phytochemicals Nqo1 Cebpb Aimp2 Hmox1 Ephb2 Maf Gsta2 Pik3ca Keap1 Gclc Mapk8 Prkca Nfe2l2 Gclm AMINO ACID METABOLISM%WIKIPATHWAYS_20260910%WP662%MUS MUSCULUS Amino acid metabolism Acadm Hadh Gss Idh1 Gsr Lars2 Bhmt Pdhx Tat Asns Aldh7a1 Vars1 Acss1 Bcat1 Farsb Cs Wars1 Auh Tdo2 Pck1 Suclg1 Pdk4 Hibch Sds Ftcd Arg2 Arg1 Aldh18a1 Gpt2 Cad Ehhadh Dlst Hmgcs2 Mccc1 Pkm Ldha Mars2 Sms Acaa1a Dld Mpst Oat Glud1 Pycr1 Odc1 Cps1 Prodh Adh5 Srm Rars1 Tpo Pcx Ogdh Aoc3 Fh Hmgcl Adh4 Mdh1 Aldh1a1 Mdh2 Acly Adh1 Eprs1 Iars1 Fah Adh7 Hnmt Hal G6pc2 Ppm1l P4ha2 Hibadh Gls Aco2 Mmut Glul Otc Cth Tph1 Maoa Ddc Pnmt Sdhd Hdc Pdha1 Sdha Dbh Th Gsta4 Got1 Got2 Ass1 Asl Cbs Gclm FOLIC ACID NETWORK%WIKIPATHWAYS_20260910%WP1273%MUS MUSCULUS Folic acid network Mthfr Txnrd1 Mtr Kmo Txnrd2 Cat Gsr Pnpo Xdh Selenok Fads2 Alox5 Gpx2 Gpx1 Ptges Gpx4 Selenow Ptgds Gpx3 Ptgis Cbs Gpx6 Msrb1 PURINE METABOLISM%WIKIPATHWAYS_20260910%WP2185%MUS MUSCULUS Purine metabolism Rrm2b Urad Adk Pde3a Urah Nudt16l2 Pde7b Guk1 Pde7a Pde2a Adcy3 Pgm2 Pgm1 Adcy4 Pold2 Nudt16 Adcy1 Pold4 Pold3 Adcy2 Gart Nme3 Gmps Adcy7 Prps1l3 Nme2 Adcy8 Gmpr Nme5 Adcy5 Prps1l1 Adcy6 Nme4 Fhit Adcy9 Dck Nme1 Prps1 Atic Gucy2e Gucy2d Prps2 Pde4a Gmpr2 Pde4b Gucy2c Nme7 Nme6 Pde8a Pde3b Pde8b Gucy2f Pole3 Impdh2 Pklr Polr2c Polr2d Impdh1 Polr2b Taf9 Pole4 Enpp1 Polr2h Enpp3 Polr2e Polr2f Pde5a Polr2l Polr2i Pde4c Aprt Polr2j Pde4d Polr3gl Nudt2 Hddc3 Nudt5 Polr3a Rrm1 Nudt9 Pde1b Pde11a Pde1c Rrm2 Polr3d Pde1a Polr3e Polr3b Prune1 Polr3c Pde6c Polr3h Pde6d Pde6a Polr3f Pde6b Polr3g Prim2 Pfas Prim1 Polr3k Pole2 Papss2 Pola2 Papss1 Nt5c2 Uox Pole Polr2a Polr2g Pkm Pold1 Xdh Gda Entpd1 Nt5c Entpd2 Nt5c1a Pnp Nt5e Nt5c1b Entpd5 Pde6g Entpd6 Pde6h Entpd3 Entpd4 Entpd8 Nt5m Allc Polr1b Polr1c Ak1 Polr1a Ak2 Ak5 Polr1d Ak4 Polr1e Hprt1 Ak7 Ak6 Polr1h Ak8 Adsl Cant1 Ampd3 Ampd2 Ampd1 Adcy10 Npr1 Pnp2 Pola1 Npr2 Adprm Pde9a Gucy1b1 Gucy1b2 Nt5c3a Pnpt1 Itpa Dguok Adss2 Adss1 Gucy1a2 Ppat Paics Ada Pde10a STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260910%WP216%MUS MUSCULUS Striated muscle contraction Myl1 Actg1 Tnnt3 Tnnt2 Tnnt1 Casq2 Ttn Tnnc2 Tmod1 Tnnc1 Tcap Dmd Acta1 Acta2 Jsrp1 Actc1 Tpm4 Smpx Tpm3 Tpm2 Tpm1 Neb Tnni3 Tnni2 Tnni1 Myl4 Myh1 Myom1 Des Myh3 Actn2 Vim Mybpc1 Actn3 Mybpc2 Myl2 Mybpc3 Myl3 Myh8 Actn4 Myh4 Myl9 Myom2 Myh6 Myh7 GLUTATHIONE AND ONE CARBON METABOLISM%WIKIPATHWAYS_20260910%WP730%MUS MUSCULUS Glutathione and one carbon metabolism Ggt5 Gss Mtr Idh1 Ahcyl2 Gsr Bhmt Anpep Shmt2 Dnmt3a Shmt1 Mat2b Oplah Ahcy Gpx2 Mtrr Gpx1 Amt Gpx4 Dnmt3b Gpx3 Cth Dnmt1 Mat1a Mthfr Gclc Cbs G6pdx Ggt1 Chdh Gclm ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1261%MUS MUSCULUS ErbB signaling pathway Hbegf Mtor Nck1 Gab1 Cblc Nrg2 Areg Hras Btc Nrg4 Nrg3 Pak4 Myc Camk2a Bad Gsk3b Mapk1 Abl1 Tgfa Mapk8 Ptk2 Prkca Map2k1 Egfr Grb2 Erbb2 Stat5a Elk1 Akt3 Eif4ebp1 Cdkn1a Cdkn1b Araf Plcg1 Pik3r5 Crk Jun Sos1 Egf Nrg1 Shc2 Src Erbb4 Erbb3 Map2k7 Ereg OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260910%WP1274%MUS MUSCULUS Oxidation by cytochrome P450 Cyp27b1 Cyp4b1 Cyp8b1 Cyb5r4 Cyb5r3 Cyb5r2 Cyp2w1 Cyb5r1 Cyp24a1 Cyp2u1 Cyp4f3 Cyp2s1 Cyp1a2 Cyp17a1 Cyp7a1 Cyp4f39 Cyp39a1 Cyp19a1 Cyp2f2 Cyp1b1 Cyp11a1 Cyp51a1 Cyp7b1 Cyp4x1 Cyp2e1 Cyp2r1 Cyp4v3 Cyb5a Cyp26c1 Cyb5b Cyp46a1 Cyp27a1 Por Cyp11b1 Cyp21a1 Cyp20a1 Cyp11b2 Cyp26b1 Cyp1a1 Cyp26a1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260910%WP385%MUS MUSCULUS Myometrial relaxation and contraction pathways Atp2a3 Atp2a2 Ryr3 Adcy3 Adcy4 Nos1 Adcy1 Il6 Sp1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Crhr1 Pde4b Gnaq Prkacb Il1b Itpr3 Prkar1a Itpr2 Prkar1b Itpr1 Gng3 Creb1 Gng5 Gng4 Gng7 Pde4d Gnas Gng8 Gngt1 Prkar2a Prkar2b Ywhah Gnb2 Gnb1 Gnb3 Gnb5 Gng11 Gng12 Gng13 Camk2g Camk2d Camk2b Camk2a Arrb2 Arrb1 Acta1 Crh Actc1 Myl4 Myl2 Nos3 Maff Ywhae Ywhab Prkcd Mylk2 Lpar1 Nfkb1 Ywhaz Atf1 Rgs4 Rgs5 Gja1 Fos Rgs2 Sfn Ackr5 Rgs3 Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Igfbp3 Rgs7 Igfbp2 Plcg2 Igfbp5 Atf5 Igfbp4 Atf4 Igfbp1 Atf3 Jun Calm3 Pkib Calca Igfbp6 Grk5 Atf6b Grk4 Pkia Grk6 Ackr3 Pkig Cnn1 Dgkz Gnb4 Gabpb1 Rln1 Actb Ryr2 Ryr1 Prkd1 Ywhaq Oxt Adm Gsto1 Ramp1 Gabpa Guca2b Guca2a Creb3 Prkcq Cald1 Rgs20 Prkcg Actg1 Plcd1 Ets2 Prkch Rgs17 Rgs18 Prkcb Rgs19 Prkce Gng2 Rgs14 Rgs16 Prkca Cacnb3 Rgs10 Rgs11 Corin Ramp3 Ramp2 Rxfp2 Rxfp1 Prkcz Atf2 Ywhag Plcg1 Oxtr Plcb3 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260910%WP1242%MUS MUSCULUS Non homologous end joining Xrcc4 Nhej1 Mre11a Rad50 Prkdc Xrcc6 Xrcc5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP193%MUS MUSCULUS Hepatocyte growth factor receptor signaling Itgb1 Pak1 Hgf Gab1 Hras Pik3ca Mapk1 Pten Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Stat3 Grb2 Mapk3 Elk1 Pxn Crkl Map4k1 Ptpn11 Raf1 Rap1a Ptk2b Rap1b Fos Itga1 Crk Jun Met Rasa1 Sos1 Src Dock1 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260910%WP2872%MUS MUSCULUS White fat cell differentiation Cebpd Cebpb Cebpa Gata3 Gata2 Nr3c1 Egr2 Klf5 Rora Nr2f2 Stat5a Ins1 Srebf1 Stat5b Mecom Ctnna1 Klf4 Klf2 Irf3 Zfp423 Rara Irf4 Tcf7l1 Foxo1 Creb1 Wnt10b Pparg Tle3 Ddit3 Nr1h3 Klf15 Ebf1 KENNEDY PATHWAY%WIKIPATHWAYS_20260910%WP1771%MUS MUSCULUS Kennedy pathway Pcyt1a Pemt Chka Sgpl1 Ptdss1 Etnk2 Ptdss2 Etnk1 Chpt1 Pisd Pcyt1b Pcyt2 Cept1 Chkb CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260910%WP553%MUS MUSCULUS Calcium regulation in cardiac cells Gjb4 Cacna1d Gjb3 Gjb6 Atp2a3 Gjb5 Atp2a2 Casq1 Atp2b2 Atp2b1 Ryr3 Atp2b3 Adcy3 Gjd2 Cacna1s Camk4 Adcy4 Atp1a4 Anxa6 Adcy1 Camk1 Kcnb1 Adcy2 Kcnj5 Pln Adcy7 Cacnb1 Atp1b3 Adcy8 Atp1b2 Adcy5 Adcy6 Gnaz Adcy9 Gnaq Prkacb Kcnj3 Gnai2 Gnai1 Gnai3 Gna11 Itpr3 Prkar1a Itpr2 Prkar1b Gnao1 Itpr1 Gng3 Gng5 Gng4 Gng7 Gnas Gng8 Gngt1 Prkar2a Prkar2b Ywhah Gnb2 Gnb1 Gnb3 Calr Gnb5 Gng11 Gng12 Gng13 Camk2g Camk2d Camk2b Camk2a Arrb2 Arrb1 Casq2 Adrb2 Adrb1 Adra1b Adra1a Adrb3 Adra1d Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Gjb1 Atp1b1 Ywhae Ywhab Prkcd Fkbp1a Ywhaz Rgs4 Rgs5 Gja1 Rgs2 Sfn Rgs3 Rgs1 Slc8a1 Rgs9 Rgs6 Rgs7 Calm3 Pkib Grk5 Grk4 Pkia Grk6 Pkig Gnb4 Ryr2 Ryr1 Prkd1 Ywhaq Prkcq Rgs20 Prkcg Prkch Rgs17 Rgs18 Prkcb Rgs19 Prkce Gng2 Rgs14 Rgs16 Prkca Cacnb3 Rgs10 Rgs11 Prkcz Ywhag Cacna1e Cacna1a Cacna1b Gja3 Gja5 Gja4 Gja8 Slc8a3 Fxyd2 Gjc1 Plcb3 Gjc2 Cacna1c Gjb2 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP407%MUS MUSCULUS Kit receptor signaling pathway Fyn Bad Mapk1 Abl1 Stap1 Grb10 Socs4 Socs6 Akt1 Matk Csf2rb Map2k1 Cltc Sh3kbp1 Cblb Grb2 Dok1 Rps6ka1 Tnfrsf10b Stat5a Kit Btk Spred1 Mpdz Stat5b Spred2 Raf1 Grb7 Grap Kitlg Plce1 Sh2b2 Tec Yes1 Ep300 Pik3r1 Pik3r2 Vav2 Epor Ptpru Pik3cg Hras Prkcb Mitf Jak2 Cish Prkca Stat3 Socs1 Ptpn6 Stat1 Cbl Crkl Ptpn11 Lyn Socs5 Vav1 Fgr Hck Plcg1 Crk Inpp5d Sos1 Rasa1 Fes Shc1 Src PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260910%WP63%MUS MUSCULUS Pentose phosphate pathway G6pdx Rpia Rpe Taldo1 Pgls Pgd Tkt PARKINSON 39 S DISEASE%WIKIPATHWAYS_20260910%WP3638%MUS MUSCULUS Parkinson 39 s disease Uba1 Park7 Ube2l6 Ube2j2 Ube2l3 Ube2j1 Mapk14 Mapk12 Casp9 Casp3 Casp7 Snca Ddc Th Ccne1 Ccne2 Cycs Atxn2 Gpr37 Pink1 Syt11 Uba7 Apaf1 Ubb Lrrk2 Htra2 Ube2g2 Ube2g1 Sncaip Eprs1 Slc6a3 Mapk11 Mapk13 Uchl1 Prkn Septin5 Casp6 Casp2 COMPREHENSIVE IL 17A SIGNALING%WIKIPATHWAYS_20260910%WP5242%MUS MUSCULUS Comprehensive IL 17A signaling Mcm3 C7 Mcm4 Mcm5 Mcm6 Mcm2 Sod2 Tgfb1 Anxa6 Il6 Orc1 Orc2 Akt1 Trp53 Igf1 Smad3 Prkacb Il1b Npm1 Mtor Mki67 Gng12 Serbp1 Sqstm1 Zmpste24 Hyou1 Cacybp Hbb-b1 Ccn2 Uggt1 Ccl5 Becn1 Mylk Cxcl12 Plch1 Cpne1 Nasp Nucks1 Rras2 Hmgb1 Arpc3 Arpc2 Arpc5 Cxcl15 Fbn1 Egfr Pik3c3 Acta1 Hbb-bh1 Stat3 Acta2 Blmh Angpt1 Tnfsf13b Gap43 Stat1 Mmp14 Mmp3 Mmp9 Upf1 Samhd1 Plaur Psmc6 Map1lc3a Map1lc3b Pon3 Atrx Hspa1b Ccl4 Ccl3 Hbb-bs Cxcl1 Snai2 Cxcl2 Snai1 Cxcl5 Ppp1r14b Rab10 Rbbp4 Tjp1 Pura Atox1 Pak3 Casp3 Bcl2 Adh1 Smad2 Ptgs2 Pcna Smad6 Smad7 Rhoa Fn1 Cdc42 Rac1 Pdgfa Pdgfb Jak2 Col1a1 Rela Mcm7 Plau C3 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP10%MUS MUSCULUS IL 9 signaling pathway Socs3 Stat5b Irs1 Ptpn11 Jak1 Kat5 Irs2 Mapk1 Tyk2 Jak3 Vcp Map2k2 Akt1 Il9 Map2k1 Il9r Shc1 Stat3 Grb2 Pik3r1 Il2rg Stat5a Mapk3 Stat1 GPCRS OTHER%WIKIPATHWAYS_20260910%WP41%MUS MUSCULUS GPCRs other Gpr165 Gpr162 Gabbr1 Fzd1 Gpr132 Or7e178 Mtnr1b Or5g26 Gpr143 Or2a7 Tas1r1 Mc4r Pth2r Or9s13 Or10p22 Cysltr1 Gpr88 Gpr84 Gpr83 Or6b9 Ghsr Or2b6 Prokr1 Adgrg1 Adrb2 Adrb1 Smo Oprm1 Tacr3 Or1j1 Calcr Casr Or7a40 Or2y1b Gpr34 Or8g20 Or1e1f Drd1 Or8c9 Celsr3 Vmn2r104 Drd2 Or1a1b Or1ad8 Celsr1 Or3a1 V1ra8 Or1e35 Drd5 Or1e34 Celsr2 Vmn1r148 Vmn1r29 Vmn1r25 Vmn1r53 Or8g19 Vmn1r54 Or4b1d Vmn1r51 Or8d1 Vmn1r52 Or8u8 Gpr146 Or1e23 Or1e16 Vmn2r107 Adora1 Or4c58 Adora3 Or51a5 Ltb4r2 Vmn1r15 Or1p1 Vmn1r13 Adgrf4 Or1x2 Tmigd3 Vmn1r14 Grm1 Vmn1r11 Or6a2 Vmn1r10 Or2z2 Vmn1r48 Or6z7 Or7a37 Or13p10 Vmn1r46 Or1a1 Or7e165 Vmn1r47 Or2n1e Gpr37l1 Or2t1 Or51a10 Or13a18 Or13a17 Or7a42 Vmn1r45 Or7a41 Or2ag2b Vmn1r42 Vmn2r32 Vmn1r65 Vmn1r43 Vmn1r62 Vmn1r63 Htr1d Gpr39 Or13a28 Or13a27 Htr1a Vmn1r58 Or2v1 Vmn1r56 Adgre5 Vmn1r50 Or3a1c Or1e17 Mrgprh Or1d2 Trhr2 Or51a39 Vmn1r49 Or2w1 S1pr1 Irx6 Vmn1r44 Vmn1r40 Vmn1r41 Or1m1 S1pr2 Or1f19 S1pr5 Or1j21 Or2a57 Vmn1r171 Vmn1r172 Ackr1 Cnr1 Oprk1 Ednra Rrh Sstr5 Ccr10 Fzd2 Vipr1 Fzd5 Fzd7 Fzd9 Xcr1 Oprl1 BDNF PATHWAY%WIKIPATHWAYS_20260910%WP2152%MUS MUSCULUS BDNF pathway Frs2 Ntrk2 Bax Serpine1 Cdc42 Rac1 Creb1 Mapk4 Trp53 Plat Bcl2 Shc1 Plg Ngfr Bdnf MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP493%MUS MUSCULUS Mapk signaling pathway Map3k13 Cdc25b Tgfb1 Mapt Mapk1 Map3k7 Akt1 Trp53 Ppp3r2 Ppp3r1 Prkaca Raf1 Ppp3cc Gna12 Il1b Nlk Ikbkb Flna Mapk7 Ikbkg Mapk4 Akt2 Mapk13 Casp6 Gadd45a Map2k7 Casp2 Map2k6 Map2k5 Ppp3ca Mapk14 Ppp3cb Hspa1a Arrb2 Arrb1 Map2k4 Casp8 Casp7 Casp1 Tab1 Mef2c Egfr Map3k14 Map3k1 Fas Braf Elk1 Mapk6 Crkl Akt3 Rac2 Rap1a Rap1b Cd14 Crk Map3k4 Pak1 Pdgfrb Pak2 Mapk12 Hspa8 Traf6 Casp9 Casp3 Tab2 Map2k2 Mapk8 Map2k1 Prkcd Grb2 Mapk9 Mapk3 Nfkb1 Nr4a1 Fos Nras Atf4 Jun Egf Bdnf Tgfbr1 Tgfbr2 Map3k8 Map3k6 Fgf4 Map3k5 Map3k20 Pla2g10 Rasgrp4 Cdc42 Myc Rasgrp1 Jund Rac1 Rasa2 Max Stmn1 Stk3 Pdgfb Prkcg Map4k4 Prkch Map4k3 Tgfb2 Prkcb Tgfb3 Fasl Nf1 Hspb1 Hspb2 Rasgrf2 Hspa5 Daxx Ppp5c Ptprr Mras Traf2 Ecsit Tmem37 Ngf Rps6ka3 Map4k1 Mink1 Prkcz Sos2 Ppm1b Kras Acvr1c Ppm1a Mapkapk2 Srf Ptpn7 Ptpn5 Atf2 Ntf4 Dusp5 Dusp4 Tnf Dusp1 Pla2g5 Acvr1b Dusp7 Dusp10 Dusp6 Taok2 Taok1 Rasa1 Gck Mapkapk5 Mapk10 Ddit3 Mos Il1a Ntrk1 Mapk8ip3 Il1r2 Il1r1 Map3k11 Map3k12 ECTODYSPLASIN A SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260910%WP3652%MUS MUSCULUS Ectodysplasin A signaling in hair follicle development Eda Sostdc1 Nfkb1 Gli1 Edaradd Relb Edar Dkk4 Ptch1 Ltb Rela Shh Dkk1 Nfkb2 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP55%MUS MUSCULUS Steroid biosynthesis F13b Hsd17b7 Hsd17b3 Hsd17b4 Hsd3b6 Hsd3b5 Hsd3b4 Cyp17a1 Hsd3b3 Hsd3b2 Hsd3b1 Hsd17b1 Hsd17b2 DYSREGULATED MIRNA TARGETING IN INSULIN PI3K AKT SIGNALING%WIKIPATHWAYS_20260910%WP3855%MUS MUSCULUS Dysregulated miRNA targeting in insulin PI3K AKT signaling Mtor Col5a3 Acaca Bad Col4a2 Flot2 Bcl2l11 Rheb Col1a2 Col3a1 Prkx Exoc7 Col1a1 Bcl2 Socs1 Mapk3 Eif4e2 Crkl Raf1 Ccnd2 Cdkn1b Sos1 Fasn Prkar2a Pik3r1 Pik3r3 ELONGATION OF VERY LONG CHAIN FATTY ACIDS%WIKIPATHWAYS_20260910%WP4491%MUS MUSCULUS Elongation of very long chain fatty acids Scd3 Scd2 Elovl6 Elovl7 Scd1 Fads2 Fads1 Scd4 Elovl2 Fasn Elovl3 Elovl4 Elovl5 Elovl1 HYPOXIA DEPENDENT SELF RENEWAL OF MYOBLASTS%WIKIPATHWAYS_20260910%WP5023%MUS MUSCULUS Hypoxia dependent self renewal of myoblasts Hey1 Myog Myod1 Hsp90b1 Pax7 Cdkn1a Myf5 Myh1 Hif1a Foxo1 Hes1 Hey2 Notch1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260910%WP2573%MUS MUSCULUS Primary focal segmental glomerulosclerosis FSGS Nck1 Fyn Tgfb1 Mme Akt1 Ptk2 Dkk1 Cd151 Tln1 Vcl Plce1 Cdkn1a Ctsl Cr1l Itga3 Cdkn1b Trpc6 Utrn Ptpro Nphs2 Vim Nphs1 Agrn Cd2ap Dag1 Krt8 Dnm1 Scarb2 Inf2 Myh9 Itgav Irf6 Podxl Myo1e Smarcal1 Wt1 Cldn1 Lmx1b Col4a5 Synpo Itgb1 Lims1 Pcna Pax2 Kirrel2 Itgb4 Kirrel3 Fat1 Lrp6 Parva Mki67 Ywhaq Itgb3 Lrp5 Camk2b Vtn Col4a4 Lamb2 Cdkn1c Cdh2 Cd80 Lama5 Ilk Notch1 Plaur Ctnnb1 Plcg1 Jag1 Actn4 Col4a3 Tlr4 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP387%MUS MUSCULUS IL 6 signaling pathway Mapt Il6 Mapk1 Map3k7 Cdk5r1 Akt1 Ppp2ca Stat5a Btk Stat5b Raf1 Hnf1a Cdk5 Nlk Tec Foxo1 Ar Pik3r1 Il6st Pik3r2 Map2k6 Cebpb Ppp2r3a Ppp2r2c Ncoa1 Ppp2r2b Ptpa Rb1 Bmx Mapk14 Ppp2r2a Ppp2r1b Ppp2r1a Foxo4 Rps6ka2 Map2k4 Sgk1 Ppp2r5d Ppp2r5b Ppp2r5a Inppl1 Eif2a Il6ra Stat3 Erbb2 Stat1 Ppp2cb Vav1 Fgr Hck Sos1 Shc1 Map3k4 Erbb3 Cdk9 Gab1 Fyn Casp9 Bad Casp3 Map2k2 Mapk8 Ptk2 Map2k1 Prkcd Grb2 Mapk3 Eif4e Nfkb1 Pxn Jak1 Eif4ebp1 Fos Ep300 Jun Crebbp Hras Rac1 Gsk3b Hsp90aa1 Foxo3 Hspb1 Jak2 Cd40 Gab2 Daxx Ppp2r5c Socs3 Rps6kb1 Ptpn11 Lyn Mapkapk2 Ptk2b Hdac1 Tyk2 Plcg1 Ppp2r5e Inpp5d Fes OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260910%WP1496%MUS MUSCULUS Oxidative damage response Pcna C1qc Cdc42 Traf6 Casp9 Tnfrsf1b Traf1 Bad Map2k4 Casp3 Tnk2 Cdkn1c C3ar1 Cr2 Traf3 Map3k9 Bag4 Bak1 Bcl2 Nfkbie Tdp2 Map3k1 Traf2 Nfkb1 Cdkn1a C5ar1 Cdkn1b Cycs Cyct Tnf Apaf1 C1qb C1qa C1ra Mapk10 C2 Mapk13 C4b C5 Gadd45a C1s1 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP116%MUS MUSCULUS Hedgehog signaling pathway Igf2 Ihh Stk36 Gli1 Gli3 Gli2 Ptch2 Sap18 Sufu Ptch1 Dyrk1a Gas1 Cdk1 Crebbp Ccnb1 Shh Sin3a Rab23 Dhh Hhip Smo GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20260910%WP2852%MUS MUSCULUS Gene regulatory network modelling somitogenesis Hes1 Tbx6 Fgf8 Epha4 Mesp2 Lfng Hes7 Ripply2 Dll1 Notch1 Wnt3a GLYCOGEN METABOLISM%WIKIPATHWAYS_20260910%WP317%MUS MUSCULUS Glycogen metabolism Calm1 Ppp2r3a Ppp2r2c Ugp2 Ppp2r2b Ptpa Pgm1 Ppp2r2a Ppp2r1b Ppp2r1a Gsk3b Ppp2r5d Ppp2r5b Ppp2r5a Ppp2ca Ppp2r5c Calm2 Gbe1 Phkb Ppp2cb Gys1 Gys2 Phka1 Phka2 Ppp2r5e Gyg1 Pygb Calm3 Phkg1 Phkg2 Agl Pygl Pygm Gsk3a ESTROGEN METABOLISM%WIKIPATHWAYS_20260910%WP1264%MUS MUSCULUS Estrogen metabolism Ugt1a2 Ugt1a1 Nqo1 Comt Gsta1 Cyp1a2 Gstm1 Cyp1b1 Cyp1a1 Sult1e1 Sult1a1 Ugt1a6 Ugt1a9 IL 7 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP297%MUS MUSCULUS IL 7 signaling pathway Muc1 Bax Mcl1 Il7r Fyn Hras Rb1 Bad Gsk3b Mapk1 Jak3 Foxo3 Bcl2l11 Akt1 Map2k2 Stam2 Map2k1 Cltc Cblb Stat3 Grb2 Il2rg Stat5a Mapk3 Stat1 Cdk4 Stam Cdk2 Cbl Stat5b Irs1 Jak1 Raf1 Lyn Ccna2 Ptk2b Irs2 Ccnd2 Irf1 Foxo1 Sos1 Blk Shc1 Pik3r1 ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260910%WP1770%MUS MUSCULUS One carbon metabolism and related pathways Gss Mtr Bcat2 Dmgdh Bhmt2 Dhfr Gsr Bhmt Mat2a Shmt2 Baat Sod3 Gnmt Dnmt3a Sod2 Ahcyl1 Sod1 Shmt1 Agxt2 Sardh Cdo1 Bcat1 Tyms Mat1a Mthfr Csad Pld1 Dnm1 Gpx2 Gpx1 Gpx4 Gpx3 Cth Gpx6 Gpx5 Gpx7 Pcyt1a Gad1 Pemt Gad2 Chka Etnk2 Etnk1 Chpt1 Pcyt1b Pcyt2 Cept1 Chkb Gclc Cbs Chdh Gclm MIR302 367 PROMOTING CARDIOMYOCYTE PROLIFERATION%WIKIPATHWAYS_20260910%WP2904%MUS MUSCULUS miR302 367 promoting cardiomyocyte proliferation Mob1b Lats2 Mst1 Yap1 MIR 193A AND MVP IN COLON CANCER METASTASIS%WIKIPATHWAYS_20260910%WP3979%MUS MUSCULUS mir 193a and MVP in colon cancer metastasis Mvp G3bp1 Caprin1 Ccnd2 Myc Ccnd1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260910%WP449%MUS MUSCULUS Complement and coagulation cascades F9 C6 Serpinf2 C7 Kng1 C9 F13b Serpine1 Cd55 C1qc Cfd Cfb Serping1 Mbl1 C4bpa Masp2 Tfpi Serpina5 C8g Cd59a Cfh Cfi Klkb1 Proc Serpind1 Cd46 Thbd Pros1 Serpinc1 A2m Cpb2 Cd55b Cr1l C3ar1 Cr2 Plaur C5ar1 F2r Bdkrb1 F3 Fgb C1qb Plau C1qa F10 Vwf C1ra Masp1 F12 F11 C2 Plat C4b Plg F2 C3 F5 F7 C5 F8 C1s1 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP373%MUS MUSCULUS IL 3 signaling pathway Gata2 Chek1 Mapk1 Akt1 Bcl2l11 Matk Csf2rb Ppp2ca Stat5a Prkaca Stat5b Raf1 Stat6 Tec Rara Mapk7 Foxo1 Creb1 Dnm1 Pik3r1 Pik3r2 Pik3cd Bmx Mapk14 Pik3ca Cish Stat3 Stat1 Mmp9 Crkl Rac2 Rap1a Id1 Vav1 Hck Crk Sos1 Shc1 Gsk3a Src Pak1 Gab1 Fyn Bad Mapk8 Ptk2 Map2k1 Rapgef1 Ywhab Bcl2 Grb2 Mapk9 Mapk3 Vcl Nfkb1 Pxn Jak1 Ywhaz Atf1 Socs2 Fcer2a Gata1 Il3ra Selp Il3 Rps6kb2 Birc5 Kcnip3 Slc2a1 Mmp2 Bax Hras Cdc42 Rac1 Tnfrsf1b Gsk3b Prkcb Hspb1 Jak2 Prkca Syk Gab2 Rack1 Mras Lck Ptpn6 Socs3 Cbl Ptpn11 Kras Lyn Mapkapk2 Atf2 Spi1 Tyk2 Bcl2l1 Inpp5d Fes Rxra TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260910%WP88%MUS MUSCULUS Toll like receptor signaling Mxd3 Map2k6 Irak1 Mapk14 Traf6 Casp3 Tab2 Casp8 Chuk Fadd Traf3 Nr2c2 Nfkb1 Irf3 Ikbkb Ikbkg Ikbke Tbk1 Ticam2 Irak4 Irak3 Ticam1 Irak2 Myd88 Ralbp1 Abi1 Mal Tlr4 Eif2ak2 Tirap Tlr2 Nfkb2 Tlr3 PDGFR ALPHA AND STMN1 COOPERATE TO EXACERBATE CYTOTOXIC EFFECTS OF VINBLASTINE%WIKIPATHWAYS_20260910%WP4398%MUS MUSCULUS PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine Pdgfra Stmn1 GPCRS ORPHAN%WIKIPATHWAYS_20260910%WP1398%MUS MUSCULUS GPCRs orphan Gpr179 Gpr4 Gpr165 Gpr180 Gpr155 Gpr161 Gpr137 Gphr Tpra1 Gpr107 Gpr137b Adgrf5 Gpr137c Wls Gpr108 Slc52a2 Gpr31 Adgrf2 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP350%MUS MUSCULUS p38 Mapk signaling pathway Tgfbr1 Pla2g4a Map2k6 Hmgn1 Mef2d Ripk1 Rasgrf1 Rps6ka5 Hras Map3k5 Cdc42 Mapk14 Myc Tradd Rac1 Max Map2k4 Map3k7 Tgfb2 Hspb1 Map3k9 Daxx Grb2 Map3k1 Traf2 Stat1 Elk1 Mapkapk2 Mknk1 Atf2 Creb1 Ddit3 Shc1 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260910%WP543%MUS MUSCULUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Acat1 Hmgcs2 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260910%WP2084%MUS MUSCULUS SREBF and miR33 in cholesterol and lipid homeostasis Mtor Srebf1 Ppara Ldlr Srebf2 Nr1h3 Hmgcr Ppargc1a Sirt1 Med15 Sirt6 CIRCULATING MONOCYTES AND CARDIAC MACROPHAGES IN DIASTOLIC DYSFUNCTION%WIKIPATHWAYS_20260910%WP4474%MUS MUSCULUS Circulating monocytes and cardiac macrophages in diastolic dysfunction Spp1 Ccr2 Il10 Ccl2 HYPOXIA DEPENDENT PROLIFERATION OF MYOBLASTS%WIKIPATHWAYS_20260910%WP5024%MUS MUSCULUS Hypoxia dependent proliferation of myoblasts Mtor Hgf Myog Myod1 Myf5 Fbxo32 Ddit4 Tsc2 Tsc1 Fgf1 Mstn Akt1 Rheb Calca Vegfa Smad2 Trim63 Igf1 Smad3 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260910%WP3857%MUS MUSCULUS Wnt signaling in kidney disease Csnk1a1 Lrp5 Rhoa Wnt5a Wnt10a Dvl1 Gsk3b Wnt1 Lrp4 Axin1 Wnt9b Fzd1 Mapk8 Invs Nlrp3 Wnt16 Wnt11 Mapk9 Wnt6 Wnt7b Wnt3a Dvl2 Dvl3 Wnt7a Btrc Wnt2 Wnt4 Wnt3 Kitlg Fzd3 Fzd2 Ctnnb1 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Wnt10b Apc Mapk10 SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20260910%WP2079%MUS MUSCULUS Serotonin receptor 2 and STAT3 signaling Gnaq Jak2 Htr2a Stat3 GLOBO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260910%WP5305%MUS MUSCULUS Globo series sphingolipid metabolism B3galnt1 B3galt5 Fut2 Gbgt1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260910%WP3626%MUS MUSCULUS Microglia pathogen phagocytosis pathway Itgb2 C1qc Pik3cg Pik3cb Pik3cd Pik3ca Rac1 Cyba Cybb Syk Pik3c3 Tyrobp Siglec12 Ptpn6 Fcgr1 Nckap1l Pik3c2a Arpc1b Fcer1g Trem3 Rac2 Trem2 Lyn Pik3r6 Rac3 Trem1 Lat Vav1 Hck Plcg2 C1qb C1qa Itgam Vav3 Pik3r1 Ncf1 Pik3r2 Ncf2 Ncf4 Pik3r3 Vav2 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260910%WP4345%MUS MUSCULUS Glycerolipids and glycerophospholipids Pnpla3 Dgkz Pcyt1a Pemt Cds1 Ptdss1 Gpat4 Pla2g1b Ptdss2 Pnpla2 Etnk1 Plpp1 Chpt1 Dgat2 Pld1 Pisd Cdipt Gpam Pcyt2 Dgat1 Agpat4 Chkb Crls1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260910%WP454%MUS MUSCULUS Osteoclast signaling Ifnb1 Itgb3 Pdgfb Spp1 Trpv5 Gpr68 Ctsk Tnfsf11 Ifnar1 Atp6v1g1 Slc9a1 Tnfrsf11b Tnfrsf11a Acp5 GPCRS SMALL LIGAND%WIKIPATHWAYS_20260910%WP353%MUS MUSCULUS GPCRs small ligand Cnr1 Lpar1 Cnr2 Ptgir Tbxa2r Ptger4 Ptgfr Ptger2 Ptgdr Ptger3 Ptger1 Ptafr S1pr1 S1pr3 S1pr2 Mtnr1a S1pr4 Mtnr1b SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20260910%WP57%MUS MUSCULUS Signal transduction of S1P receptor Sphk2 Sphk1 Mapk6 Akt3 Gnai2 Gnai1 Gnai3 Mapk12 Mapk7 Mapk1 S1pr1 Akt2 Akt1 S1pr3 S1pr2 S1pr5 Smpd2 Plcb3 Racgap1 Pik3c2g Mapk3 Asah2 GLUCURONIDATION%WIKIPATHWAYS_20260910%WP1241%MUS MUSCULUS Glucuronidation Ugt1a2 Ugt1a1 Ugt1a8 Ugt2a1 Ugt2a2 Ugt2a3 Hk1 Ugp2 Ugt1a5 Ugt2b1 Pgm2 Pgm3 Pgm1 Pgm5 Ugt2b34 Ugdh Ugt1a10 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260910%WP1270%MUS MUSCULUS Endochondral ossification Frzb Ptch1 Tgfb1 Ddr2 Chst11 Fgf18 Hmgcs1 Alpl Col10a1 Col2a1 Sox6 Adamts1 Akt1 Mmp13 Sox9 Ift88 Adamts5 Adamts4 Scin Pth Igf1 Nkx3-2 Cab39 Thra Slc38a2 Prkaca Pthlh Kif3a Serpinh1 Bmpr1a Stat5b Timp3 Bmp6 Acan Cst5 Pth1r Mgp Ctsl Enpp1 Fgf2 Spp1 Runx3 Runx2 Ghr Calm1 Tgfb2 Cdkn1c Mef2c Igf1r Vegfa Sox5 Stat1 Igf2 Ihh Mmp9 Gli3 Hdac4 Fgfr3 Bmp7 Plau Fgfr1 Plat SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260910%WP1983%MUS MUSCULUS Splicing factor NOVA regulated synaptic proteins Csn3 Aplp2 Grik2 Ncdn Efna5 Atp2b1 Camk2g Cav2 Gabbr2 Cdh2 Mapk9 Grin1 Prkcz Rap1gap Kcnma1 Clasp1 Cask Dab1 Kcnj6 Epb41l2 Grin2b Clstn1 Agrn Stxbp2 Epb41l3 Cadm3 Epb41l1 Mapk4 Cadm1 Gabrg2 Kcnq2 Stx2 Map4 Neo1 Chl1 Snw1 Plcb4 Ank3 Gphn Terf2ip Ntng1 Epb41 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4351%MUS MUSCULUS Omega 9 fatty acid synthesis Scd2 Elovl6 Acot1 Acot2 Fads2 Fads1 Acsl1 Elovl2 Fasn Elovl3 Elovl5 Acsl3 Elovl1 Acsl4 DRAVET SYNDROME SCN1A A1783V POINT MUTATION MODEL%WIKIPATHWAYS_20260910%WP5298%MUS MUSCULUS Dravet syndrome Scn1a A1783V point mutation model Gabbr1 Cacnb1 Gabbr2 Grm3 Akt1 Grin2a Nfkb1 Ldha Kcnj3 Grin1 Epb41l3 Slc2a1 Mtor Gls Glul Rasgrf1 Prr5 Rictor Fgf13 Scn1a Pik3ca Scn1b Camk2a Stxbp1 Gabra4 Ppp1r1b Gabra3 Stxbp3 Gabra2 Pcdh19 Slc2a3 Slc6a1 Slc16a7 Maob Slc16a1 Cacnb3 Slc12a5 Stx8 Gabra1 Kcna2 Gria4 Gria3 Scn2b Maoa Gria1 Chd2 Stx16 Ldhb Mlst8 Ctps2 Gad1 Cacna2d3 Gad2 Kcnj9 Kdr Scn3a Scn3b Gfap Slc1a3 Slc38a3 Slc17a7 Cacnb4 Scn4b Mapkap1 Tnf Kcnj10 Gabrb1 Gabrb3 Prr5l Cacna1a Cacna1b Slc1a2 Mapk11 EICOSANOID LIPID SYNTHESIS MAP%WIKIPATHWAYS_20260910%WP4335%MUS MUSCULUS Eicosanoid lipid synthesis map Pla2g4a Pgs1 Pla2g4b Ptges Ptgds Pla2g6 Ptgs2 Alox5 Pla2g5 BURN WOUND HEALING%WIKIPATHWAYS_20260910%WP5056%MUS MUSCULUS Burn wound healing Hbegf Lama1 Nos3 Gja1 Nos2 Tgfb1 Tnf Flii Tgfbrap1 Pecam1 Prodh2 Nlrp3 Vegfa Col1a1 Acta1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260910%WP3673%MUS MUSCULUS Hfe effect on hepcidin production Bmp6 Smad7 Tmprss6 Hjv Hfe Hamp Id1 EGFR1 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP572%MUS MUSCULUS EGFR1 signaling pathway Sp1 Mapk1 Grb10 Akt1 Snca Sh3kbp1 Cblb Rps6ka1 Stat5a Smad3 Stat5b Raf1 Grb7 Prkar1a Mapk7 Foxo1 Creb1 Krt8 Dnm1 Pik3r1 Pik3r2 Sin3a Pik3r3 Map2k7 Cebpb Map2k5 Cebpa Pik3cg Pik3cb Pik3cd Map3k3 Mapk14 Pik3ca Camk2a Stxbp1 Appl1 Rps6ka2 Map2k3 Inppl1 Egfr Map3k14 Stat3 Map3k1 Stat2 Stat1 Elk1 Crkl Araf Itch Vav1 Crk Sos1 Shc1 Sh2d3c Map3k4 Grb14 Src Elk4 Eps8 Ralb Bcar1 Krt7 Nck1 Pak1 Eps15 Gab1 Cblc Map3k2 Ap2a1 Hat1 Wasl Pitpna Rab5a Pld2 Errfi1 Usp6nl Pik3c2b Ralgds Casp9 Wnk1 Rfxank Arf4 Cav2 Hip1 Tnk2 Sh3bgrl Shoc2 Cav1 Ndufa13 H3f4 Snrpd2 Ptk6 Nck2 Asap1 Map2k2 Mapk8 Git1 Sh3gl3 Map2k1 Ywhab Epn1 Elf3 Grb2 Plec Klf11 Sh3gl2 Plscr1 Ceacam1 Mapk3 Tnip1 Tgif1 Htt Appl2 Ptpn12 Pxn Mta2 Jak1 Krt18 Krt17 Atf1 Mcf2 Reps1 Spry2 Gja1 Fos Rbbp7 Eps15l1 Reps2 Ctnnd1 Pebp1 Pkn2 Pld1 Zpr1 Plcg2 Nras Jun Egf Smad2 Vav3 Ralbp1 Abi1 Vav2 Ripk1 Rps6ka5 Hras Prkd1 Csk Cdc42 Myc Jund Rac1 Prkci Prkcb Eef1a1 Jak2 Rgs16 Prkca Gab2 Ptprr Socs1 Ptpn6 Socs3 Rps6ka3 Cbl Prkcz Sos2 Ptpn11 Kras Ptk2b Ptpn5 Dusp1 Hdac1 Plcg1 Dok2 Rasa1 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260910%WP519%MUS MUSCULUS Proteasome degradation Ifng H2ax Psma3 Psma6 Uba7 Psma5 Ubb Psme3 Psma2 Psma1 Psme2 Psme1 Psmd12 Psmd11 Psmd10 Uchl1 Ube2b Psmd13 Psmb10 Uchl4 Psmb5 Uba1 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ube2d3 Ube2d1 Psma7 Psmc5 Psmc2 Rpn2 Psmc1 Psmc4 Psmc3 Rpn1 Ubc Psmb8 Psmd7 H2az1 Psmd6 Psmd9 Psmd8 Psmd3 Psmd2 Psmd5 Psmd4 Ube2d2a Hist1h2an H2-Q10 Psma4 Psmc6 Psmb9 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260910%WP723%MUS MUSCULUS Wnt signaling pathway and pluripotency Cd44 Dvl1 Map3k7 Wnt1 Fzd1 Trp53 Ppp2ca Axin2 Hnf1a Nlk Fzd4 Ppard Tcf4 Ctbp1 Ctbp2 Lrp6 Ppp2r2c Lrp5 Ppp2r2b Ptpa Nkd1 Ppp2r2a Ppp2r1b Ppp2r1a Foxd3 Tcf7l1 Ppp2cb Prkcd Mapk9 Mmp7 Ctnnd1 Lef1 Ep300 Jun Crebbp Prkd1 Pafah1b1 Rhoa Wnt5a Myc Wnt10a Prkcq Gsk3b Prkcg Prkch Prkci Prkcb Prkce Axin1 Ldlr Wnt9b Prkca Csnk1e Fbxw2 Wnt16 Wnt11 Ppp2r5c Wnt6 Wnt7b Ppp2r2d Wnt3a Dvl2 Nanog Dvl3 Hnf1b Zbtb33 Wnt7a Wnt2 Nfya Sox2 Prkcz Nkd2 Wnt4 Pou5f1 Ppm1j Wnt3 Fosl1 Fzd3 Ccnd2 Fzd2 Ccnd3 Ctnnb1 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Ppp2r5e Plau Wnt10b Apc Frat1 Mapk10 Racgap1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260910%WP166%MUS MUSCULUS Apoptosis modulation by HSP70 Nfkb1 Ripk1 Bid Aifm1 Hspa1a Casp9 Casp3 Tnfrsf1a Apaf1 Casp8 Casp7 Fadd Mapk10 Map3k1 Fas Casp6 Casp2 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260910%WP1258%MUS MUSCULUS Homologous recombination Pold1 Mre11a Rpa1 Atm Rad51 Rad52 Brca2 Pold2 Nbn Rad54b Pold4 Pold3 Rad50 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260910%WP4347%MUS MUSCULUS Eicosanoid metabolism via cyclooxygenases COX Pla2g4a Ptgdr2 Ptgdr Cyp4f3 Prxl2b Hpgd Ehhadh Ptgir Acaa1a Tbxa2r Tbxas1 Cyp4a12a Ptgfr Cyp4f14 Cyp4a12b Pla2g5 Cyp4a10 Akr1b1 Ptgr2 Ptgr1 Pla2g4b Acox1 Ppard Ptges Ptgds Acox2 Acox3 Ptgis Ptgs1 Pla2g6 Ptgs2 HEART DEVELOPMENT%WIKIPATHWAYS_20260910%WP2067%MUS MUSCULUS Heart development Tbx5 Foxa2 Tbx2 Hand1 Bmpr2 Gata6 Gata4 Mapk1 Pitx2 Mef2c Fgf10 Fgf8 Vegfa Vegfc Shh Vegfb Bmp4 Foxc1 Notch1 Hey1 Isl1 Bmp2 Bmpr1a Ptpn11 Srf Ctnnb1 Foxh1 Foxc2 Hand2 Tbx10 Smyd1 Nfatc4 Nkx2-5 Bhlhe40 Smad1 Bmp10 Nfatc1 Smad4 Nfatc3 Hey2 Nfatc2 Erbb3 Tbx20 Irx4 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260910%WP1272%MUS MUSCULUS Selenium micronutrient network mt-Co2 Mthfr Mtr Kmo Cat Gsr Pnpo Xdh mt-Co1 Selenok Tbxas1 Selenop Fads2 Alox5 Gpx2 Gpx1 Ptges Fads1 Gpx4 Ptgds Gpx3 Ptgis Gpx6 MECHANISMS ASSOCIATED WITH PLURIPOTENCY%WIKIPATHWAYS_20260910%WP1763%MUS MUSCULUS Mechanisms associated with pluripotency Cd44 Tfeb Mapk1 Pias4 Cdh1 Psen1 Akt1 Trp53 Dkk1 Prkaca Cdk2 Mdm2 Sall1 Raf1 Cdkn1a Tfap2a Pin1 Dazl Tert Ctbp1 Ctbp2 Mtor Lrp5 Pik3cd Nkd1 Nppb Rock2 Mitf Rock1 Shh Ncl Notch1 Inhbb Foxd3 Atrx Id1 Tcf7l1 Hck Rbpj Rbbp4 Fgfr1 Sos1 Yy1 Casp3 Gbx2 Pten Esrrb Grb2 Nr2f6 Cad Nr2f2 Mta2 Nr5a2 Rbbp7 Tpo Rras Itgb1 Sp3 Fgf4 Rela Icam1 Ins1 Nanog Irs1 Dhx9 Ptpn11 Hnrnpu Acvr1c Atf2 Ctnnb1 Lifr Npr1 Acvr1b Twist1 Bmpr2 Gata6 Znf281 Relb Rcor2 Thap11 Cer1 Sf1 Skic8 Dnmt3a Tcl1 Tgfb1 Uhrf1 Hif1a Nobox Hcfc1 Sp1 Insr Dvl1 Zmym2 Znf143 Nme2 Kdm6b Lefty1 Cabin1 Dnmt3b Bcam Ocln Fzd1 T T2 Lif Dnmt1 Dnmt3l Phc1 Ehmt2 Nodal Gdf9 Bmp4 Rel Ehmt1 Ctr9 Paf1 Smad3 Gatad2a Gatad2b Cubn Ezh2 Ezh1 Kat5 Terf2 Myod1 Ep400 Ube2i Ddb1 Ptprs Hells Suz12 Pbrm1 Pias2 Ctcf Tle5 Xpo4 Parp1 Med12 Tet1 Brca1 Creb1 Zfx Acvr1 Nr2f1 Rtn4r Mtf2 Lyar H3-3b Stk40 Rbl2 Rybp Leo1 Mbd3 Il6st Dpysl2 Cdx2 Mbd2 Sin3a Satb2 Satb1 Gadd45a Pou2f1 Elp4 Wwp2 Mef2d Zscan10 Dffa Nr2c1 Rif1 Nr0b1 Ncoa1 Zfp42 Mpl Ipo7 Etv5 Kpnb1 Fgf5 Mycn Ppp2r1a Ipo9 Pim1 Dgka Grsf1 Sgk1 Pim3 Tle4 Tle2 Fbxo15 Kdm1a Usp7 Hira Perp Mef2c Sall4 Sall3 Klf5 Tcf7 Jarid2 Stat3 Tfap2c Niban1 Nedd4l Tfcp2l1 Smo Jade1 Otx2 Plet1 Zfp57 Nacc1 Kpna2 Kmt2d P4ha1 Ogt Cdc73 Kdm4c Cers2 Zic2 Zic3 Gadd45gip1 Cdk2ap1 Eras Utf1 Eed Mybl2 Hand2 Kdm5c Kdm6a Rcn2 Ewsr1 Chd4 Smarca2 Smarca4 Sumo1 Smarca5 Dppa4 Trim28 Trim24 Epop Rnf2 Rest Zfp219 Mta1 Gab1 Smarcad1 Arid3b Ercc5 Trim33 Kdm3a Tbx3 Pml Ssrp1 Smarcc1 Map2k1 Mapk3 Nfkb1 Jak1 Tfe3 Fos Socs2 Lef1 Igfbp3 Ep300 Spp1 Crebbp Smad1 Smad2 Smad4 Tgfbr1 Smad7 Hras Wnt5a Myc Gsk3b Prkcg Axin1 Wnt3a Sox2 Pou5f1 Klf4 Klf2 Ccnd1 Hdac2 Hdac4 Hdac1 Cdkn2a Apc GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260910%WP456%MUS MUSCULUS GPCRs class B secretin like Adgrl2 Adgrl3 Adgrl4 Adgrl1 Calcr Ghrhr Calcrl Adcyap1r1 Pth1r Glp1r Vipr2 Vipr1 Adgre5 Gcgr Adgrg2 Adgre1 Sctr Glp2r Pth2r Crhr2 Crhr1 Gipr MONOAMINE GPCRS%WIKIPATHWAYS_20260910%WP570%MUS MUSCULUS Monoamine GPCRs Drd5 Adra2a Adra2c Adra2b Htr4 Htr6 Htr7 Adrb2 Htr2a Adrb1 Htr2c Adra1b Htr2b Adra1a Adrb3 Adra1d Htr5b Htr5a Htr1d Htr1f Htr1b Htr1a Chrm1 Hrh1 Chrm3 Chrm2 Chrm5 Chrm4 Hrh2 Drd1 Drd2 Drd3 Drd4 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260910%WP1498%MUS MUSCULUS Dopaminergic neurogenesis Ascl1 Foxa2 Gli1 Ret Tgfb1 Neurog2 En2 En1 Nkx2-2 Gbx2 Slc18a2 Msx1 Nkx6-1 Lmx1a Cdkn1c Neurod1 Wnt1 Pitx3 Fgf8 Stat3 Shh Ddc Otx2 Gli2 Sox2 Nr4a2 Th Aldh1a1 Slc6a3 Lmx1b MIR 127 IN MESENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260910%WP3991%MUS MUSCULUS miR 127 in mesendoderm differentiation Foxa2 Acvr1 Acvr2a Cfc1 T Lefty2 T2 Smad2 Nodal Smad4 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260910%WP238%MUS MUSCULUS Osteoblast signaling Pdgfrb Pdgfra Tnfsf11 Pth1r Bglap2 Tnfrsf11b Slc17a2 Col1a1 Fgf23 Pth PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260910%WP4835%MUS MUSCULUS Peroxiredoxin 2 induced ovarian failure Hsd3b3 Bax Cyp11a1 Star Cycs Prdx2 Casp3 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260910%WP1252%MUS MUSCULUS Amino acid conjugation of benzoic acid Acss2 Glyat CHOLESTEROL BIOSYNTHESIS%WIKIPATHWAYS_20260910%WP103%MUS MUSCULUS Cholesterol biosynthesis Dhcr7 Fdft1 Lss Sqle Pmvk Sc5d Mvd Msmo1 Hmgcr Hmgcs1 Idi1 Cyp51a1 Fdps Nsdhl Mvk NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP1256%MUS MUSCULUS Nod like receptor NLR signaling pathway Ikbkg Map3k7 Chuk Ephb2 Mapk8 Cd40 Erbin Rela Ikbkb DISTAL CONVOLUTED TUBULE 1 DCT1 CELL%WIKIPATHWAYS_20260910%WP4183%MUS MUSCULUS Distal convoluted tubule 1 DCT1 cell Stk39 Slc12a3 Wnk4 Kcnj16 Clcnkb Wnk1 Cab39 B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP274%MUS MUSCULUS B cell receptor signaling pathway Hnrnpk Mapk1 Map3k7 Stap1 Akt1 Bcl2l11 Cblb Dok1 Rel Rps6ka1 Ppp3r1 Cdk6 Btk Cdk4 Cdk2 Raf1 Sh2b2 Tec Itpr2 Ikbkb Itpr1 Foxo1 Ikbkg Creb1 Mapk4 Pdpk1 Pik3r1 Pik3r2 Pik3cg Ptprc Ppp3ca Rb1 Mapk14 Ppp3cb Cdk7 Casp7 Chuk Arpc3 Arpc2 Cr2 Arpc5 Stat3 Rps6 Stat1 Braf Elk1 Crkl Vav1 Hck Crk Nfkbia Sos1 Blk Was Shc1 Gsk3a Bcar1 Nck1 Gab1 Fyn Casp9 Pip4k2a Map2k2 Mapk8 Ptk2 Map2k1 Rapgef1 Prkcd Bcl2 Grb2 Mapk3 Cd72 Sla2 Chst15 Pdk2 Cd81 Plcg2 Gtf2i Actr2 Actr3 Dok3 Jun Rasgrp3 Pip4k2b Pip4k2c Cd79a Cd79b Bcl10 Pik3ap1 Bcl6 Cd19 Arpc4 Vav2 Itk Rap2a Dapp1 Bax Bank1 Cd22 Atp2b4 Prkd1 Plekha2 Plekha1 Zap70 Rhoa Hcls1 Csk Card11 Lat2 Blnk Lime1 Lcp2 Prkcq Ptpn18 Gsk3b Cd5 Fcgr2b Sh3bp2 Cmtm3 Prkcb Nedd9 Prkce Pip5k1b Pip5k1a Syk Gab2 Rela Lck Ptpn6 Pip5k1c Arpc1b Cbl Rps6kb1 Map4k1 Sos2 Ptpn11 Lyn Ccna2 Mapkapk2 Ptk2b Ccne1 Ccnd2 Atf2 Ccnd3 Ctnnb1 Dusp4 Hdac5 Plcg1 Hdac7 Dusp6 Inpp5d Rasa1 Nfatc1 Nfatc3 Nfatc2 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260910%WP3625%MUS MUSCULUS Tyrobp causal network in microglia C1qc Maf Rbm47 Rps6ka1 Stat5a Rgs1 Spp1 Runx3 Itgax Itgam Ncf2 Tgfbr1 Itgb2 Hcls1 Tnfrsf1b Gpx1 Adap2 Plek Il18 Sft2d2 Cytl1 Tmem106a Lyl1 Dpyd Cd84 Tyrobp Kcne3 Abcc4 Nckap1l Bin2 Npc2 Elf4 Lhfpl2 Cd37 Samsn1 Creb3l2 Ppp1r18 Il10ra Zfp36l2 Apbb1ip Cd4 Fkbp15 Hlx Rnase6 Tcirg1 Il13ra1 Loxl3 Gapt Slc7a7 Pycard Capg Sh2b3 Igsf6 Nrros Gal3st4 Cxcl16 Slc1a5 C3 INSULIN SIGNALING%WIKIPATHWAYS_20260910%WP65%MUS MUSCULUS Insulin signaling Map4k5 Map3k13 Rab4a Egr1 Xbp1 Tbc1d4 Ehd1 Map4k2 Ehd2 Snap25 Snap23 Rhoj Ptprf Rhoq Cap1 Rrad Insr Inpp4a Mapk1 Vamp2 Map3k7 Rps6ka4 Rps6ka6 Sgk3 Grb10 Sgk2 Flot2 Arf6 Akt1 Myo1c Rheb Ptpn1 Pfkl Stx4 Arhgap33 Cblb Pfkm Ppp1cc Rps6ka1 Map3k10 Kif3a Raf1 Lipe Sh2b2 Enpp1 Ikbkb Slc2a4 Mapk7 Foxo1 Stxbp2 Mapk4 Pdpk1 Akt2 Mapk13 Pik3r1 Pik3r2 Pik3r3 Map2k7 Mtor Map2k6 Map2k5 Pik3cg Pik3cb Pik3cd Map3k3 Mapk14 Pik3ca Stxbp1 Rps6ka2 Map2k4 Sgk1 Map2k3 Stxbp3 Inppl1 Map3k9 Igf1r Pik3c3 Map3k14 Map3k1 Elk1 Mapk6 Rac2 Gys1 Gys2 Gyg1 Crk Sos1 Pik3r4 Shc3 Shc1 Map3k4 Shc2 Grb14 Gab1 Cblc Map3k2 Mapk12 Pten Map2k2 Mapk8 Map2k1 Rapgef1 Prkcd Grb2 Mapk9 Sorbs1 Mapk3 Eif4e Eif4ebp1 Fos Rps6kb2 Arf1 Slc2a1 Jun Map3k8 Map3k6 Rps6ka5 Hras Map3k5 Rac1 Prkcq Gsk3b Map4k4 Prkch Map4k3 Tsc2 Prkci Tsc1 Prkcb Foxo3 Prkca Socs1 Pik3c2a Socs3 Rps6ka3 Cbl Irs1 Rps6kb1 Map4k1 Mink1 Prkcz Sos2 Ptpn11 Irs4 Trib3 Srf Irs3 Mapk10 Mapk11 Cyth3 Stxbp4 Prkaa1 Prkaa2 Kif5b Pik3c2g Map3k11 Flot1 Map3k12 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260910%WP4346%MUS MUSCULUS Cholesterol metabolism with Bloch and Kandutsch Russell pathways Hsd17b7 Fads2 Hmgcs1 Fads1 Cyp51a1 Elovl2 Elovl3 Fdps Elovl4 Ch25h Elovl5 Nsdhl Ggps1 Hmgcs2 Mvk Cyp46a1 Lbr Nr1h2 Dhcr7 Cyp27a1 Fdft1 Scd2 Acat2 Soat2 Lss Soat1 Sqle Tm7sf2 Pmvk Sc5d Mylip Mvd Idi2 Msmo1 Ebp Dhcr24 Scd1 Acsl1 Fasn Acsl3 Acsl4 Acot1 Acot2 Acat1 Srebf2 Abcg1 Hmgcr Abca1 Cyp7a1 Srebf1 Idi1 Nr1h3 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260910%WP4344%MUS MUSCULUS Sphingolipid metabolism overview Sphk2 Sphk1 Sgpl1 Smpd1 Cers6 Cers2 Plpp3 Cers4 Cers3 Plpp1 Asah1 Cers1 Sgms1 Sgms2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Degs1 Gdf1 Kdsr Sgpp2 Ugcg Sgpp1 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260910%WP374%MUS MUSCULUS Prostaglandin synthesis and regulation Scgb1a1 Pla2g4a Hsd11b1 Hsd11b2 Anxa5 Anxa4 Anxa3 Anxa2 Anxa1 S100a10 Ptger4 Ednrb Ednra Anxa6 Ptger2 Ptgdr Ptger3 Ptger1 Hpgd Cyp11a1 Ptgir Tbxas1 Ptgfr Ptgds Ptgis Ptgs1 Edn1 Ptgs2 Anxa8 Prl S100a6 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260910%WP1251%MUS MUSCULUS Metapathway biotransformation Ugt2a2 Gss Ugt2a3 Ugt1a5 Gsr Ugt1a10 Chst11 Chst10 Akr7a2 Chst12 Chst13 Chst14 Naa80 Ndst1 Ndst2 Sult1c2 Ndst3 Ndst4 Sult4a1 Sult1b1 Hs3st3b1 Gstcd Hs2st1 Tpmt Naa50 Nat8 Nat2 Ephx1 Akr1a1 Nat9 Sult2b1 Sult6b1 Nat8l Inmt Naa40 Nat10 Comt Nat14 Nnmt Hs3st3a1 Chst1 Sult2a1 Chst3 Chst2 Chst5 Chst4 Chst7 Chst9 Naa30 Chst8 Gstz1 Hs3st4 Hs3st1 Hs3st2 Hs3st5 Hs3st6 Naa20 Akr1d1 Kcnab1 Kcnab2 Sult1e1 Sult1a1 Kcnab3 Ugt1a6 Gal3st1 Ugt1a9 Fmo1 Ugt1a2 Fmo3 Ugt1a1 Fmo2 Fmo5 Hs6st3 Hs6st2 Fmo4 Hs6st1 Akr1b10 Gal3st3 Baat Gal3st2 Cyp2w1 Cyp2u1 Cyp4f3 Cyp2s1 Cyp17a1 Cyp4f39 Cyp39a1 Cyp19a1 Cyp2f2 Ephx2 Cyp1b1 Cyp11a1 Cyp51a1 Cyp7b1 Cyp4x1 Cyp2e1 Cyp2r1 Cyp4v3 Glyat Cyp26c1 Cyp46a1 Cyp27a1 Cyp11b1 Cyp21a1 Cyp20a1 Cyp11b2 Cyp1a1 Hnmt Cyp27b1 Gstk1 Cyp4b1 Cyp8b1 Gsto1 Mgst3 Gsto2 Mgst2 Mgst1 Cyp24a1 Cyp1a2 Gpx2 Cyp7a1 Gpx1 Gpx4 Gpx3 Gpx5 Gstp1 Gstt2 Gstt1 Gsta3 Gsta4 Gsta1 Gsta2 Gstm7 Gstm5 Akr1b1 Cyp26b1 Gstm4 Gstm1 Gal3st4 Cyp26a1 T CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP480%MUS MUSCULUS T cell receptor signaling pathway Mapk1 Abl1 Cabin1 Akt1 Cblb Stat5a Stat5b Grap Mapk7 Dlg1 Itpr1 Cd2ap Creb1 Pik3r1 Pik3r2 Cebpb Ptprc Ppp3cb Cish Map3k1 Ncl Stat1 Braf Crkl Rac2 Rap1a Dtx1 Vav1 Crk Sos1 Was Shc1 Arhgdib Sh2d3c Src Txk Nck1 Pak1 Muc1 Fyn Sla Prkd2 Sit1 Sh2d2a Lax1 Wipf1 Fcrl5 Rasgrp2 Arhgef6 Unc119 Ripk2 Pag1 Tubb5 Map2k2 Fyb1 Ptk2 Homer3 Map2k1 Rapgef1 Pstpip1 Cd8a Grb2 Enah Ptprj Acp1 Ptprh Mapk3 Skap2 Skap1 Vasp Dnm2 Arhgef7 Tuba4a Ptpn12 Pxn Evl Cd247 Cd3g Cd3e Ptpn3 Stk39 Dock2 Fos Cd3d Cd2 Dusp3 Def6 Trat1 Sla2 Nfam1 Wasf2 Grap2 Khdrbs1 Ptpn22 Dbnl Jun Crebbp Bcl10 Vav3 Abi1 Vav2 Itk Zap70 Card11 Cdc42 Git2 Lime1 Lcp2 Prkcq Cd5 Shb Sh3bp2 Nedd9 Jak3 Syk Gab2 Lck Ptpn6 Cbl Map4k1 Sos2 Ptpn11 Lyn Lat Ptk2b Cd4 Ctnnb1 Plcg1 Hdac7 Sh2b3 Rasa1 Nfatc2 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP29%MUS MUSCULUS Notch signaling pathway Notch4 Adam17 Notch2 Notch3 Dll1 Dll3 Kat2b Dll4 Rbpjl Dvl1 Hes1 Hes5 Psen1 Psen2 Ncstn Aph1a Mfng Notch1 Dvl2 Numb Dvl3 Maml3 Numbl Aph1b Dtx1 Tnf Hdac2 Maml1 Hdac1 Rbpj Jag2 Dtx2 Jag1 Dtx3 Cirsr Dtx4 Dtx3l Kat2a Crebbp Rfng Snw1 Ptcra Ctbp1 Lfng Ncor2 Ctbp2 FOCAL ADHESION PI3K AKT MTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2841%MUS MUSCULUS Focal adhesion PI3K Akt mTOR signaling pathway Nos1 Fgf18 Mapk1 Akt1 Ppp2ca Cab39 Kit Mdm2 Raf1 Kitlg Cdkn1a Gng10 Cdkn1b Ikbkb Gng3 Ikbkg Fgf2 Gng5 Gng4 Gng7 Pdpk1 Akt2 Gng8 Gngt1 Gngt2 Pik3r1 Pik3r2 Prl Gnb2 Mtor Acaca Gnb1 Epo Gnb3 Epor Gng11 Efna5 Gng12 Pik3cg Gng13 Pik3cb Pik3cd Fgf13 Pik3ca Slc2a3 Fgf10 Fgf8 Igf1r Egfr Fgfr2 Flt1 Rps6 Angpt1 Mlst8 Akt3 Kdr Rab10 Fgfr3 Pik3r5 Fgfr1 Met Sos1 Pik3r4 Fgf15 Nos3 Pdgfrb Pdgfra Pik3c2b Col11a2 Casp9 Bad Col2a1 Pten Ptk2 Grb2 Eif4e Itga7 Itga8 Itga5 Itga6 Itga9 Itga3 Itga4 Itga2 Itga10 Itga11 Nras Itgax Itgav Itgam Itgae Itgal Rab11b Phlpp1 Itgad Phlpp2 Itgb8 Ppp2r3d Ngfr Itgb7 Ppp2r3c Ulk1 Itgb1 Mtcp1 Itga2b Pik3ip1 Itgb4 Tbc1d1 Itgb5 Fgfr4 Itgb2 Gng14 Fgf4 Fgf16 Itgb3 Rptor Fgf17 Fgf14 Ifnab Osmr Fgf12 Fgf11 Hif3a Fgf20 Fgf21 Fgf22 Ifna4 Ifna5 Hsp90aa1 Jak3 Ifna6 Foxo3 Ifna7 Jak2 Ifna2 Ifna9 Foxa1 Strada Rab8a Comp Ifna1 Fgf3 Csf3r Fgf6 Ppp2r2d Rab2a Ins1 Fgf7 Gh Eif4e1b Ngf Fgf9 Rps6kb1 Irs1 Hsp90ab1 Csf1 Csf3 Kras Ins2 Creb3l3 Irs4 Creb3l4 Creb3l1 Irs2 Crtc2 Csf1r Atf2 Irs3 Akt1s1 Stk11 Cab39l Efna4 Prlr Efna1 Efna2 Efna3 Flt4 Pfkfb4 Lpar6 Pfkfb3 Pfkfb2 Pfkfb1 Vwf Elavl1 Slc2a2 Angpt2 Lpar5 Angpt4 Creb5 Epha2 Ifna13 Ifna14 Ifna11 Ifnar2 Tcl1b4 Tcl1b1 Rab14 Tek Tcl1 Hif1a Insr Rheb Igf1 Lipe Hsp90b1 Epas1 Slc2a4 Cdc37 Foxo1 Creb1 Ghr Ppp2r3a Ppp2r2c Ppp2r2b Osm Ppp2r1b Ppargc1a Ppp2r1a Ppp2r5d Ppp2r5b Ppp2r5a Il6ra Srebf1 Eif4e2 F2r Ppp2cb Gys1 Gys2 Chrm1 Chrm2 Il7r Map2k2 Map2k1 Lpar4 Mapk3 Lpar3 Lama1 Lpar2 Lama2 Lpar1 Lama3 Jak1 Eif4ebp1 Itgb6 Lamb3 Il3ra Thbs1 Rps6kb2 Spp1 Slc2a1 Atf4 Egf Tnc Atf6b Tnn Tnr Tnxb Col5a2 Col5a3 Hgf Gnb4 Col5a1 Pgf Hras Reln Lama4 Thbs2 Fn1 Thbs4 Il2ra Pdgfc Il2rb Pdgfd Il2 Chad Creb3 Pdgfa Pdgfb Vtn Gsk3b Ddit4 Col4a4 Tsc2 Col4a1 Lamb2 Tsc1 Col4a2 Fgf1 Col4a6 Gng2 Ibsp Lamb1 Col1a2 Pelo Col3a1 Col11a1 Vegfa Col1a1 Vegfd Vegfc Ppp2r5c Vegfb Lama5 Eif4b Col6a2 Il2rg Il4ra Lamc3 Pik3c2a Lamc1 Lamc2 Thbs3 Ifnb1 Creb3l2 Nos2 Ppp2r5e Ifnar1 Prkaa1 Prkaa2 Pik3c2g PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2316%MUS MUSCULUS PPAR signaling pathway Acadm Cpt2 Slc27a1 Gk Aqp7 Rxrg Dbi Angptl4 Scp2 Cyp4a30b Lpl Cyp4a32 Olr1 Cyp4a31 Gk2 Cyp4a29 Fads2 Apoa1 Acaa1b Apoa2 Cd36 Pck1 Apoa5 Pltp Pck2 Cyp4a14 Fabp2 Fabp3 Fabp5 Fabp6 Scd4 Acadl Fabp7 Ehhadh Acsbg1 Sorbs1 Acsbg2 Hmgcs2 Mmp1b Scd3 Cyp27a1 Apoc3 Scd2 Rxrb Me1 Slc27a5 Slc27a4 Slc27a2 Acaa1a Cpt1b Cpt1c Slc27a6 Plin1 Adipoq Scd1 Ppard Ppara Pdpk1 Pparg Acsl1 Acsl5 Mmp1a Acsl6 Ucp1 Acsl3 Acsl4 Cyp8b1 Fabp4 Fabp1 Cyp7a1 Ubc Ilk Cyp4a12a Cyp4a12b Cyp4a10 Acox1 Acox2 Acox3 Nr1h3 Cpt1a Rxra TGF BETA RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP258%MUS MUSCULUS TGF beta receptor signaling pathway Cd44 Cdc25a Tgfb1 Sp1 Dvl1 Map3k7 Trp53 Skp1 Axin2 Smad3 Cdk6 Cdk4 Cdk2 Btrc Cdkn1a Pard3 E2f5 Stambpl1 Cdc27 Pias1 Dab2 Cdc23 Pias2 Dcp1a Ctcf Rbx1 Prkar1b Eid2 Hgs Foxo1 Nup153 Gipc1 Sdc2 Cul1 Anapc5 Cdk1 Snip1 Anapc4 Ar Anapc1 Anapc2 Rbl2 Snx4 Rbl1 Trap1 Snx2 Esr1 Snx1 Pik3r1 Prkar2a Anapc7 Pik3r2 Cited1 Snx6 Cops5 Nup214 Sparc Map2k6 Fnta Cdc16 Xpo1 Foxg1 Zeb1 Ncoa1 Tfdp2 Anapc10 Camk2g Smurf2 Rb1 Kpnb1 Stk11ip Camk2d Mapk14 Ppp2r2a Hoxa9 Camk2b Nfyb Camk2a Nfyc Arrb2 Foxo4 Strap Fzr1 Kat2b Ap2b1 Map2k3 Acvrl1 Fosb Mef2a Rock1 Tab1 Mef2c E2f4 Sumo1 Snw1 Hspa8 Yap1 Cav1 Mapk8 Hnf4a Erbin Prkcd Fkbp1a Tgif1 Trp73 Fos Zeb2 Foxh1 Skil Eng Lef1 Ep300 Runx2 Atf3 Jun Junb Tgfbr3 Crebbp Smad2 Smad4 Zfyve9 Tgfbr1 Tgfbr2 Smad6 Smad7 Ube2d3 Ube2d1 Vdr Myc Jund Ets1 Tgfb2 Prkcb Tgfb3 Axin1 Foxo3 Daxx Ube2d2a Eif3i Nfya Ccne1 Atf2 Ctnnb1 Stk11 Ccnd1 Hdac1 Tfdp1 Ccnb2 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260910%WP567%MUS MUSCULUS Eukaryotic transcription initiation Tbp Polr3e Polr3b Polr2a Polr3h Polr2g Mnat1 Polr3k Cdk7 Polr2k Taf13 Taf12 Gtf2h2 Gtf2h4 Gtf2h3 Ercc2 Ercc3 Polr1b Gtf2a2 Polr1c Gtf2b Taf7 Polr1a Taf6 Ilk Taf5 Gtf2e1 Polr1d Gtf2e2 Ak6 Polr2c Gtf2f2 Polr2b Taf9 Polr2h Polr2e Polr2i Polr2j Gtf2h1 Ccnh Polr3d TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP246%MUS MUSCULUS TNF alpha NF kB signaling pathway Rpl8 Mcm5 Relb Akap8 Alpl Fadd Akt1 Skp1 Ppp2ca Rel Eif4a3 Prkaca Nr2c2 Pias3 Btrc Ube2i Ikbkb Polr2h Flna Cdc37 Ikbkg Cul1 Ikbke Akt2 Csnk2a2 Csnk2a1 Mark2 Fbl Ywhah Csnk2b Casp2 Map2k5 Map3k3 Tradd Papola Traf1 Casp8 Casp7 Chuk Tab1 Traf3 Bag4 Map3k14 Nfkbie Map3k1 Birc3 Birc2 Stat1 Nkiras1 Rpl4 Nkiras2 Nlrp4e Kpna2 Rpl6 Unc5cl Dpf2 Kcnq1 Azi2 Ppp1r13l Rnf216 Ddx3x Usp2 Polr1g Fbxw11 Casp8ap2 Txlna Tank Actl6a Smarce1 Tifa Cdc34 Traip Nfkbia Nfkbiz Glg1 Smarca4 Sumo1 Ripk3 Cradd G3bp2 Dcaf7 Cops3 Src Nfkbib Kpna6 Nfkb2 Iqgap2 Mcc Kpna3 Dap Gab1 Map3k2 Bcl3 Tab3 Ccar2 Traf4 Pfdn2 Traf5 Pml Faf1 Tnfrsf8 Smarcc1 Smarcb1 Traf6 Rasal2 Pkn1 Peg3 Bcl7a Cyld Casp3 Fkbp5 Tab2 Tnip2 Pdcd2 Cav1 Nsmaf Ripk2 Zfand5 Cflar Commd1 Ptk2 Trpc4ap Ywhae Fancd2 Ywhab Elp1 Psmd1 Ktn1 Usp11 Smarcc2 Rnf25 Tnip1 Tnfaip3 Lrpprc Mtif2 Nfkb1 Ywhaz Pebp1 Gtf2i Tbk1 Capn3 Crebbp Psmd12 Psmd13 Rpl30 Psmb5 Map3k8 Ripk1 Rps6ka5 Rps11 Psmc2 Rps13 Tnfrsf1b Psmc1 Gsk3b Psmc3 Tnfrsf1a Hsp90aa1 Psmd7 Psmd6 Hspb1 Psmd3 Polr1b Rack1 Polr1c Rela Polr1a Traf2 Polr1d Polr1e Hsp90ab1 Rps6kb1 Prkcz Ptpn11 Mcm7 Ywhag Tnf Hdac2 Hdac1 Hdac6 Tnfrsf11a CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP2292%MUS MUSCULUS Chemokine signaling pathway Adcy3 Adcy4 Adcy1 Adcy2 Mapk1 Adcy7 Ccr9 Adcy8 Ccr8 Adcy5 Ccr6 Adcy6 Akt1 Ccr4 Adcy9 Prkx Ccr3 Ccr2 Prkaca Prkacb Stat5b Raf1 Gnai2 Gnai1 Gnai3 Pard3 Gng10 Ikbkb Gng3 Ikbkg Gng5 Gng4 Plcb2 Gng7 Akt2 Gng8 Gngt1 Gngt2 Pik3r1 Pik3r2 Pik3r3 Gnb2 Gnb1 Gnb3 Gnb5 Gng11 Pik3cg Gng12 Pik3cb Gng13 Pik3cd Pik3ca Ccl20 Ccl5 Arrb2 Arrb1 Cxcl12 Cxcr1 Cxcr2 Cxcr3 Rock2 Chuk Cxcr4 Rock1 Cxcr5 Cxcr6 Cxcl15 Stat3 Stat2 Stat1 Braf Crkl Akt3 Rac2 Rap1a Rap1b Ccl4 Ccl3 Vav1 Cxcl1 Fgr Cxcl2 Hck Cxcl5 Pik3r5 Crk Nfkbia Sos1 Shc3 Was Shc1 Gsk3a Shc2 Nfkbib Bcar1 Pak1 Wasl Rasgrp2 Ptk2 Map2k1 Prkcd Grb2 Mapk3 Tiam1 Nfkb1 Tiam2 Pxn Cx3cr1 Shc4 Ppbp Grk1 Grk2 Elmo1 Dock2 Ccl21a Cxcl13 Cxcl14 Ccl27a Xcl1 Ccl19 Ccl17 Ccl9 Ccl11 Ccl8 Nras Ccl12 Ccl7 Ccl6 Ccl1 Pf4 Prex1 Grk5 Cx3cl1 Ccl28 Grk4 Vav3 Ccl26 Ncf1 Ccl24 Grk6 Ccl25 Ccl22 Vav2 Itk Gnb4 Ccr1l1 Gng14 Hras Rhoa Csk Cdc42 Rac1 Gsk3b Ccl2 Plcb1 Prkcb Jak3 Gng2 Foxo3 Jak2 Rela Cxcl10 Cxcl9 Prkcz Sos2 Kras Lyn Ptk2b Ccr10 Ccr1 Xcr1 Cxcl16 Ccr5 Plcb4 Plcb3 HYPOXIA DEPENDENT DIFFERENTIATION OF MYOBLASTS%WIKIPATHWAYS_20260910%WP5025%MUS MUSCULUS Hypoxia dependent differentiation of myoblasts Egln1 Myog Cdkn1a Myf5 Mapk14 Myh1 Cdkn1b Hif1a Myf6 Bhlhe40 Vegfa Hif1an Notch1 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP151%MUS MUSCULUS IL 5 signaling pathway Mapk1 Unc119 Akt1 Map2k2 Csf2rb Rapgef1 Prkcd Grb2 Mapk9 Rps6ka1 Stat5a Mapk3 Btk Dnm2 Nfkb1 Stat5b Jak1 Raf1 Ywhaz Rap1gap Sh2b2 Cdkn1b Alox5ap Alox5 Jun Itgam Pik3r1 Pik3r2 Pla2g4a Sox4 Sdcbp Bax Itgb2 Pik3cg Hras Hcls1 Mapk14 Il2rb Rac1 Pim1 Gsk3b Il5 Prkcb Foxo3 Jak2 Syk Stat3 Icam1 Socs1 Ptpn6 Stat1 Il5ra Elk1 Cbl Crkl Ptpn11 Kras Lyn Ptk2b Atf2 Ccnd3 Ctnnb1 Vav1 Hck Nfkbia Gsk3a Shc1 Shc2 FATTY ACID BETA OXIDATION STREAMLINED %WIKIPATHWAYS_20260910%WP3588%MUS MUSCULUS Fatty acid beta oxidation streamlined Acadm Cpt2 Acads Hadha Hadh Hadhb Slc27a1 Eci1 Slc25a20 Slc27a3 Acat1 Fabp4 Fabp1 Cd36 Fabp2 Fabp3 Acadl Fabp7 Slc27a5 Slc27a4 Slc27a2 Cpt1b Slc27a6 Decr1 Acadvl Acsl1 Echs1 Acsl5 Cpt1a Acsl6 Acsl3 Acsl4 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260910%WP207%MUS MUSCULUS Nucleotide GPCRs Tmigd3 P2ry6 P2ry4 P2ry2 Lpar6 P2ry1 Adora2b Adora2a Adora1 Adora3 Lpar4 Ltb4r TCA CYCLE%WIKIPATHWAYS_20260910%WP434%MUS MUSCULUS TCA cycle Aco2 Idh2 Idh3g Pdhx Suclg2 Pdk3 Sucla2 Idh3a Pdhb Idh3b Pdp1 Pdp2 Cs Dlat Suclg1 Pdk4 Dlst Sdhd Sdhc Pdha1 Sdhb Pdha2 Sdha Dld Pdk2 Pcx Ogdh Fh Pdk1 Mdh1 Mdh2 ID SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP512%MUS MUSCULUS ID signaling pathway Bmpr2 Myf6 Id3 Hes1 Igf1 Smad3 Tgif1 Bmp2 Cdk2 Nfkb1 Myog Bmp6 Myod1 Myf5 Atf3 Tert Tcf3 Rbl2 Egf Rbl1 Smad1 Smad4 Pax2 Smad5 Rb1 Acvrl1 Elk3 Cd40lg Pax5 Pax8 Id2 Tcf12 Id4 Msc Igf1r Vegfa Tcf7l2 Flt1 Rela Psmd4 Lck Elk1 Ngf Srebf1 Irs1 Kdr Ccna2 Ccne1 Ctnnb1 Id1 Elk4 OVARIAN INFERTILITY%WIKIPATHWAYS_20260910%WP273%MUS MUSCULUS Ovarian infertility Tbp Egr1 Cebpb Mlh1 Vdr Ptger2 Fshr Cyp19a1 Nr5a1 Zp3 Inha Zp2 Gdf9 Syne2 Bmpr1b Lhcgr Smad3 Dmc1 Cdk4 Msh5 Pgr Nrip1 Atm Smpd1 Ccnd2 Cdkn1b Prlr Dazl Gja4 Ncor1 Esr2 SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260910%WP1266%MUS MUSCULUS SIDS susceptibility pathways Ascl1 Gata3 Adcyap1r1 Gata2 Nr3c1 Ret Il6 En1 Sp1 Cav3 Nkx2-2 Hes1 Hes5 Htr2a Rora Nfkb1 Htr1a Ctcf Ppargc1b Creb1 Ep300 Ar Lmx1b Gnb3 Ryr2 Ppargc1a Il10 Il6ra Tph1 Maoa Ddc Deaf1 Scn5a Ece1 Ybx1 Nfya Adcyap1 Kcnh2 Chrnb4 Phox2b Chrnb2 Kcnq1 Slc6a4 Hspd1 Cc2d1a Vipr2 Avp Vipr1 Tph2 Phox2a Tnf Nkx3-1 Pou3f2 Foxm1 Cdca7l Tlx3 Fev Chrna4 C4b C4a Rest FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP1269%MUS MUSCULUS Fatty acid beta oxidation Acadm Cpt2 Acads Hadha Hadh Hadhb Gk Eci1 Slc25a20 Acat1 Lpl Gk2 Acadl Lipe Cpt1b Crat Dld Pnpla2 Chkb Gcdh Tpi1 Decr1 Lipc Gpd2 Acss2 Lipf Acadvl Acsl1 Echs1 Acsl5 Cpt1a Acsl6 Acsl3 Acsl4 SPINAL CORD INJURY%WIKIPATHWAYS_20260910%WP2432%MUS MUSCULUS Spinal cord injury Mag Prb1a Klk8 Egr1 Rtn4 Bcan Gdnf Efnb2 Ptpra Cspg4 Nox4 Ltb Btg2 Tgfb1 Ptprz1 Nos1 Slit1 Il6 Slit2 Slit3 Chst11 Rhoc Mapk1 Rgma Vcan Sema6a Mmp12 Ccng1 Tnfsf13 Cd47 Sox9 Ncan Xylt1 Trp53 Ccr2 Cdk4 Cdk2 Grin1 Acan Il1b E2f5 Cdk1 Rtn4r Gadd45a Anxa1 Ppp3ca Rb1 Rock2 E2f1 Tnfsf13b Gap43 Tacr1 Mmp9 Gfap Epha4 Mbp Cxcl1 Cxcl2 Rhob Tlr4 Casp3 Col2a1 Arg1 Fkbp1a Ltb4r Mapk3 Ifng Nr4a1 Ntn1 Gja1 Fos Pla2g2a Selp Vim Pla2g6 Ngfr Bdnf Rhoa Myc Il2 Il4 Ccl2 Fcgr2b Col4a1 Prkca Icam1 Cxcl10 Nos2 Ccnd1 Tnf Pla2g5 Il1a Aqp4 Pdyn Zfp36 Omg Il1r1 Pirb C5 Plxna2 ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260910%WP339%MUS MUSCULUS ESC pluripotency pathways Bmpr2 Dvl1 Mapk1 Fgf18 Wnt1 Akt1 Fzd1 Lif Bmp4 Bmpr1a Mdm2 Raf1 Hnf1a Fzd4 Mapk7 Fgf2 Acvr1 Mapk4 Akt2 Il6st Pik3r2 Mtor Map2k6 Map2k5 Lrp6 Lrp5 Pik3cd Fgf13 Fgf5 Map2k3 Fgf8 Fgf10 Egfr Fgfr2 Stat3 Braf Elk1 Mapk6 Akt3 Selenop Araf Eras Fgfr3 Fgfr1 Sos1 Fgf15 Pdgfrb Gab1 Pdgfra Mapk12 Pten Map2k2 Map2k1 Fgf23 Grb2 Jak1 Nog Fos Actr2 Jun Egf Smad1 Smad4 Smad9 Smad5 Smad6 Fgfr4 Smad7 Fgf4 Hras Fgf16 Fgf17 Wnt5a Fgf14 Myc Fgf12 Wnt10a Fgf11 Pdgfa Pdgfb Fgf20 Gsk3b Fgf21 Fgf22 Fgf1 Axin1 Wnt9b Wnt16 Wnt11 Fgf3 Wnt6 Fgf6 Bmpr1b Wnt7b Wnt3a Fgf7 Dvl2 Dvl3 Fgf9 Wnt7a Wnt2 Ptpn11 Wnt4 Wnt3 Fzd3 Fzd2 Ctnnb1 Fzd5 Lifr Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Wnt5b Wnt10b Apc POLYOL PATHWAY%WIKIPATHWAYS_20260910%WP1265%MUS MUSCULUS Polyol pathway Akr1b1 Sord Aldob Khk MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260910%WP2910%MUS MUSCULUS Mecp2 and associated Rett syndrome Mag Cebpd Sp3 Fgf4 Oprk1 Hnrnpf Rbfox1 Sp1 Nf1 Mef2c Gamt Fgf3 E2f1 Mecp2 Cnp Gprin1 Csrp1 Smc3 Fut8 Ybx1 Pou4f1 Gad1 Ezh2 Grin1 Apoc2 Gabrr2 Nrep Dlx5 Myt1 Arhgef26 Sst Taf1 Tap1 Cdon Ctcf Mbp Pou3f2 Creb1 Tet1 Fgf2 Hnrnph1 Prpf3 Ncor1 Sin3a Bcl6 Bdnf Rest FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP5128%MUS MUSCULUS Fibrin complement receptor 3 signaling pathway Itgb2 Irak1 Rhoa Pik3ca Traf6 Il6 Ccl2 Chuk Akt1 Syk Cblb Rela Tyrobp Rel Cxcl10 Nfkb1 Fcer1g Ifnb1 Irf3 Nos2 Rassf5 Ikbkb Il12b Tnf Lbp Cxcl3 Cd14 Ikbkg Ly96 Fgb Fga Ticam2 Irak4 Itgam Ticam1 Fgg Irak2 Plat Myd88 Plg Src Tlr4 Tirap Tlr3 LAC PHE PATHWAY%WIKIPATHWAYS_20260910%WP5240%MUS MUSCULUS Lac Phe pathway Cndp2 Abcc5 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260910%WP79%MUS MUSCULUS Tryptophan metabolism Hadh Cat Hsd17b10 Acat1 Cyp1a2 Prmt1 Wars1 Cyp19a1 Tdo2 Cyp2f2 Cyp1b1 Maob Cyp7b1 Cyp2e1 Aanat Tph1 Rnf25 Ddc Asmt Mdm2 Inmt Dhcr24 Cyp4f14 Aldh1a2 Ogdh Aldh3a2 Ube3a Aldh9a1 Cyp2j6 Gcdh Cyp2c55 Aldh1a1 Aadat Ubr5 Aldh2 Aox1 Afmid Cyp1a1 Aoc1 Echs1 Haao Kynu Acmsd Ido1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260910%WP578%MUS MUSCULUS Leptin insulin signaling overlap Ins1 Dgkz Lepr Socs3 Irs1 Pik3cg Irs4 Socs2 Irs2 Irs3 Insr Pdpk1 Akt1 Jak2 Lep Stat3 Pik3r3 Socs1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260910%WP300%MUS MUSCULUS Histone modifications Hdac1 Hat1 Ehmt2 Hdac2 Ehmt1 ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20260910%WP3864%MUS MUSCULUS Robo4 and VEGF signaling pathways crosstalk Robo4 Kdr Vegfa Rac1 Src Slit2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260910%WP412%MUS MUSCULUS Oxidative stress response Ugt1a1 Mt1 Gabpb1 Txn2 Txnrd1 Nqo1 Nfix Hmox1 Txnrd2 Cat Gsr Mapk14 Sod3 Sod2 Sod1 Mgst1 Cyba Sp1 Gpx1 Gpx3 Maoa Gstt2 Nfkb1 Fos Gclc Junb Mapk10 Cyp1a1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260910%WP189%MUS MUSCULUS GPCRs class A rhodopsin like Or13j1 Or8b12c Or10d1 Or8b12i Or8c15 Or8c16 Or2d3b Or8d2b Or8d1b Tcp10b Or11h4 Fpr2 Or8b12 Or8b40 Or8b39 Or8b101 Or6e1 Or10j5 Gpr45 Or2ag2 Or2ag1 Or8g23 Or8g24 Or8g26 Or8g27 Or8c8 Or8g28 Or8g18 Or10d4b Or10d4c Or10d1c Or8g2b Or2ag19 Or8g32 Or8g34 Or8g35 Or8g36 Or8g37 Or6b6 Or2ag20 Or13c7d Or13c7 Or13c7b Or8g30 Or2d2 Or2d4 Or2d3 Or8g53 Or8g55 Or13e8 Or8d23 Or8a1 Or8g20 Fpr-rs4 Fpr-rs3 Or8b4 Or2d36 Or10a4 Or10a5 Or10a2 Or8g19 Or6a2 Or2ag2b Trhr2 Rho Adora2b Adora2a Ednrb Rrh Htr4 Ptgdr Trhr Htr6 Htr7 Oprd1 C3ar1 Galr2 Galr1 Sstr5 Avpr2 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Avpr1a Htr5b Htr5a Tbxa2r Fpr1 Nmbr Ptgfr Agtr1a Agtr1b Ccr1 Oxtr Npy6r Grpr Cckar Nmur1 Ntsr2 Ntsr1 Ptger4 Mc2r Ptger2 Gabbr1 Ptger3 Fshr Ptger1 Ccr9 Ccr8 Gpr63 Ccr6 Ccr4 Ccr3 Ccr2 Mtnr1a Or8g17 Cckbr Cmklr1 Agtr2 Mc1r Rgr Mc4r Or10n1 Ptafr Cysltr1 Mc3r Gpr87 P2ry13 P2ry12 Gpr83 P2ry14 Mas1 Gpr50 F2rl1 F2rl2 F2rl3 Adra2a Or6b9 Gpr19 Adra2c Hcar2 Or5p57 Or2c1 Adra2b Gpr12 Cxcr2 Npy1r Cxcr3 Gpr65 Cxcr4 Cxcr5 Adrb2 Opn1sw Or8a1b Adrb1 Adra1b Adra1a Adrb3 Adra1d Lhcgr Gpr27 Mc5r Oprm1 C5ar1 Or7a40 F2r Aplnr Bdkrb2 Gpr37 Bdkrb1 Gpr33 Chrm1 Hrh1 Chrm3 Gpr35 Chrm2 Gpr34 Chrm4 Hrh2 Drd3 Drd4 Opn4 Opn1mw Opn3 Ccrl2 Gper1 Adora3 Ptgdr2 Npy5r Tmigd3 Htr2a Htr2c Htr2b Gpr37l1 Ltb4r Or8b8 Npy4r Cx3cr1 Ptgir Gpr3 Htr1d Htr1f Htr1b Htr1a Tshr P2ry6 P2ry4 P2ry2 P2ry1 Ackr3 Npy2r Cnr1 Ackr2 Cnr2 Ccr1l1 Oprk1 Oxt Avp Brs3 Fpr-s1 Oprl1 Ccr5 Galr3 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260910%WP1263%MUS MUSCULUS Mitochondrial gene expression Tfb1m Tfb2m Mterf1a Gabpb2 Mterf3 Tfam Pprc1 Polrmt Ppp3ca Camk4 Gabpa Ppargc1a Nrf1 Ppargc1b Myef2 Sp1 Hcfc1 Creb1 Esrra SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260910%WP2140%MUS MUSCULUS Serotonin and anxiety related events Ppp3ca Nlgn1 Fos Htr1a Grin2d Prkcb Plek Plcd4 Crhr1 Arc Htr2a Htr2c Crh IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260910%WP37%MUS MUSCULUS IL 1 signaling pathway Sqstm1 Irak1 Il1rap Peli1 Tollip Traf6 Sirpa Capns1 Il1rn Mapk1 Map3k7 Tab2 Chuk Casp1 Akt1 Mapk8 Tab1 Map2k1 Elp1 Map3k14 Rela Mapk3 Nfkb1 Ptpn11 Prkcz Il1b Capn1 Plcg1 Irak4 Nfkbia Irak3 Irak2 Il1a Myd88 Il1r2 Il1r1 Nfkbib ESTROGEN SIGNALING%WIKIPATHWAYS_20260910%WP1244%MUS MUSCULUS Estrogen signaling Hdac8 Polr2a Gper1 Polr2g Sp1 Mapk1 Akt1 Map2k1 Bcl2 Grb2 Mapk9 Prkaca Nfkb1 Polr2c Gtf2f2 Fos Polr2b Taf9 Ikbkb Polr2h Polr2e Ikbkg Creb1 Polr2f Brca1 Ep300 Polr2i Polr2j Jun Gnas Gtf2h1 Crebbp Gngt1 Ncor1 Esr1 Sin3a Tbp Gnb1 Hras Mnat1 Mapk14 Pik3ca Cdk7 Polr2k Taf13 Taf12 Chuk Gtf2h2 Gtf2h4 Gtf2h3 Ercc2 Ercc3 Gtf2a2 Gtf2b Taf7 Taf6 Ilk Taf5 Gtf2e1 Braf Gtf2e2 Elk1 Ak6 Hdac3 Ccnd1 Hdac2 Hdac5 Hdac4 Hdac1 Hdac7 Hdac6 Sos1 Shc2 Ccnh Src GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260910%WP157%MUS MUSCULUS Glycolysis and gluconeogenesis Hk1 Pdhx Gpi Eno3 Eno2 Mpc1 Mpc2 Pgam2 Pck1 Pgam1 Slc2a5 Gapdh Ldhc Fbp1 Pfkl Fbp2 Ldhal6b Aldob Gapdhs Pfkm Aldoc Aldoa EG433182 Pgk1 Pgk2 Pkm Pfkp Ldha G6pc1 Hk2 Hk3 Pklr Dld Slc2a4 Slc2a1 Pcx Mdh1 Mdh2 Pdhb Dlat Slc2a3 Ldhb Pdha1 Pdha2 Got1 Got2 Tpi1 Gck Slc2a2 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY %WIKIPATHWAYS_20260910%WP4690%MUS MUSCULUS Sphingolipid metabolism integrated pathway Sphk2 Sphk1 Cers5 Sgpl1 Smpd1 Cers6 Cers2 Plpp3 Cers4 Cers3 Plpp1 Asah1 Cers1 Sgms1 Sgms2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Degs1 Gdf1 Kdsr Sgpp2 Ugcg Sgpp1 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260910%WP222%MUS MUSCULUS Cytokines and inflammatory response Tgfb1 Il2 Il6 Il10 Il4 Pdgfa Il5 Ifna1 Ifng Ifnb1 Csf1 Csf3 Il11 H2-Eb1 Il15 Il1b Il13 Il12a Cd4 Il7 Csf2 Il12b Tnf Il3 Cxcl1 Cxcl3 Il1a LUNG FIBROSIS%WIKIPATHWAYS_20260910%WP3632%MUS MUSCULUS Lung fibrosis Hmox1 Tgfb1 Il6 Ccr3 Ccr2 Nfe2l2 Igf1 Dsp Mecp2 Il1b Il13 Csf2 Grem1 Il12b Eln Skil Atp11a Parn Fgf2 Sftpa1 Ccl11 Fam13a Spp1 Mmp2 Mt2 Elmod2 Dpp9 Tert Sftpc Cysltr2 Cma1 Egf Calca Muc5b Edn1 Stn1 Timp1 Rtel1 Ptx3 Hgf Cebpb Smad7 Ccn2 Ccl5 Il4 Pdgfa Ccl2 Pdgfb Il5 Fgf1 Tgfa Cxcl15 Fgf7 Mmp9 Csf3 Ccl4 Ccl3 Tnf Cxcl2 Bmp7 Plau GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260910%WP4820%MUS MUSCULUS GDNF RET signaling axis Spry1 Pax2 Ift25 Agtr2 Sox11 Gli3 Fat4 Sall1 Gata3 Robo2 Gdnf Ret Gfra1 Ctnnb1 Grem1 Slit2 Foxc2 Lhx1 Bmp4 Eya1 Sox17 Foxc1 Ift27 STATIN PATHWAY%WIKIPATHWAYS_20260910%WP1%MUS MUSCULUS Statin pathway Apoc3 Lrp1 Soat1 Apoc2 Apoc1 Lcat Scarb1 Apoa4 Apoe Lpl Hmgcr Abca1 Apoa1 Cyp7a1 Dgat1 Pltp Ldlr Lipc Mttp EICOSANOID METABOLISM VIA LIPOXYGENASES LOX %WIKIPATHWAYS_20260910%WP4348%MUS MUSCULUS Eicosanoid metabolism via lipoxygenases LOX Ggt5 Dpep2 Mgst3 Mgst2 Cyp4f3 Gpx1 Hpgd Gpx4 Ephx2 Ehhadh Acaa1a Cyp4a12a Cyp4f14 Alox12 Cyp4a12b Alox5 Cyp4a10 Dpep1 Lta4h Ptgr2 Alox15 Ptgr1 Acox1 Acox2 Acox3 Ggt1 Ltc4s FAS PATHWAY AND STRESS INDUCTION OF HSP REGULATION%WIKIPATHWAYS_20260910%WP571%MUS MUSCULUS FAS pathway and stress induction of HSP regulation Pak1 Dffa Pak2 Rb1 Faf1 Lmnb1 Ptpn13 Lmnb2 Casp9 Prkdc Mapkapk3 Sptan1 Map2k4 Casp3 Dffb Map3k7 Casp8 Ripk2 Fasl Casp7 Cflar Fadd Hspb1 Mapk8 Bcl2 Daxx Map3k1 Fas Mapkapk2 Tnf Parp1 Apaf1 Jun Il1a Arhgdib Lmna Casp6 MAPK CASCADE%WIKIPATHWAYS_20260910%WP251%MUS MUSCULUS Mapk cascade Map2k6 Map3k2 Hras Mapk14 Map3k3 Mapk12 Map2k4 Map2k3 Rasa3 Mapk1 Map2 Sipa1 Map2k2 Map2k1 Map3k1 Mapk3 Braf Elk1 Raf1 Kras Mbp Araf Nras Rras Jun Mapk10 Plcb3 Map3k12 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260910%WP683%MUS MUSCULUS Leptin and adiponectin Lepr Acaca Adipor2 Adipor1 Prkag1 Lep Adipoq Prkab1 Prkaa1 Cpt1a IRON HOMEOSTASIS%WIKIPATHWAYS_20260910%WP1596%MUS MUSCULUS Iron homeostasis Il6 Tnf Il6ra Slc40a1 Ftl1 Hamp2 Il1a Tf Hjv Hfe Tfr2 Ireb2 Hamp Fth1 APOPTOSIS%WIKIPATHWAYS_20260910%WP1254%MUS MUSCULUS Apoptosis Mcl1 Casp9 Bad Casp3 Fadd Cflar Bcl2l11 Akt1 Trp53 Bcl2 Igf1 Tnfrsf10b Nfkb1 Mdm2 Trp73 Bid Hells Ikbkb Ikbkg Birc5 Jun Irf6 Pik3r1 Casp6 Casp2 Bax Ripk1 Dffa Myc Tradd Tnfrsf1b Traf1 Map2k4 Dffb Tnfrsf1a Casp8 Fasl Casp7 Chuk Casp1 Traf3 Igf1r Bak1 Rela Nfkbie Hrk Birc3 Map3k1 Fas Prf1 Traf2 Birc2 Trp63 Bok Igf2 Bcl2l2 Tnfsf10 Bnip3l Scaf11 Pmaip1 Lta Irf7 Irf3 Irf5 Gzmc Tnfrsf21 Casp4 Tnfrsf25 Xiap Irf4 Diablo Tnf Irf1 Irf2 Bcl2l1 Apaf1 Nfkbia Mapk10 Cradd Nfkbib MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260910%WP401%MUS MUSCULUS Mitochondrial long chain fatty acid beta oxidation Acadm Cpt2 Acads Hadha Hadh Eci1 Slc25a20 Scp2 Pecr Acadvl Acsl1 Acadl Ehhadh Cpt1a Acsl3 Acsl4 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260910%WP4350%MUS MUSCULUS Omega 3 omega 6 fatty acid synthesis Pla2g4a Acot1 Acot2 Fads2 Pla2g5 Acox1 Pla2g4b Fads1 Acox3 Pla2g6 Acsl1 Elovl2 Elovl5 Acsl3 Acsl4 RETINOL METABOLISM%WIKIPATHWAYS_20260910%WP1259%MUS MUSCULUS Retinol metabolism Rlbp1 Lrat Rarb Rxrg Rarg Scarb1 Lpl Abcg5 Cd36 Cyp2e1 Sult2b1 Rxrb Rara Dhrs3 Rdh8 Rdh12 Aldh1a3 Cyp26b1 Aldh1a2 Rdh10 Bco2 Bco1 Npc1l1 Adh4 Rbp7 Aldh1a1 Abcg8 Adh1 Rpe65 Rbp4 Rbp2 Retsat Rbp1 Sult1a1 Rdh5 Rxra Crabp1 Cyp26a1 Crabp2 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260910%WP327%MUS MUSCULUS GPCRs class C metabotropic glutamate pheromone Gprc5c Casr Gprc5b Gprc5a Gabbr1 Gprc5d Grm1 Gabbr2 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260910%WP523%MUS MUSCULUS Regulation of actin cytoskeleton Ezr Arhgef4 Myh10 Rdx Msn Ssh3 Ssh2 Ssh1 Vil1 Cyfip2 Brk1 Baiap2 Diaph3 Apc2 Mapk1 Fgf18 Rassf7 Fgd1 Tmsb4x Arhgap35 Gsn Wasf1 Pip5kl1 Abi2 Raf1 Gna12 Fgf2 Mapk4 Slc9a1 Pik3r1 Pik3r2 Pik3r3 Pik3cg Gng12 Pik3cb Pik3cd Fgf13 Fgf5 Pik3ca Mylk Rras2 Rock2 Rock1 Arpc5 Fgf8 Fgf10 Egfr Pik3c3 Fgfr2 Braf Mapk6 Rac2 Rac3 F2r Bdkrb2 Bdkrb1 Cd14 Vav1 Chrm1 Myl3 Chrm3 Fgfr3 Pik3r5 Chrm2 Crk Fgfr1 Chrm5 Sos1 Chrm4 Pik3r4 Gna13 Arhgef1 Was Fgf15 Iqgap1 Dock1 Bcar1 Pak1 Nckap1 Pdgfrb Diaph1 Cfl1 Pdgfra Cfl2 Pak6 Pak3 Pak2 Pak5 Myl1 Pak4 Limk1 Pik3c2b Pfn1 Pip4k2a Arhgef6 Map2k2 Ptk2 Git1 Map2k1 Fgf23 Enah Mapk3 Vcl Arhgef7 Pxn Itga1 Wasf2 Nras Rras Pip4k2b Egf Pip4k2c Ppp1r12a Actb Fgfr4 Fgf4 Actn1 Fgf16 Fgf17 Rhoa Csk Fn1 Fgf14 Cdc42 Rac1 Fgf12 Fgf11 Pdgfa Pdgfb Fgf20 Actg1 Fgf21 Fgf22 Fgf1 Pip5k1b Pip5k1a Fgf3 Mras Fgf6 Ins1 Fgf7 Pip5k1c Pik3c2a Fgf9 Sos2 Kras Ins2 Apc Mos F2 Pik3c2g MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260910%WP441%MUS MUSCULUS Matrix metalloproteinases Mmp12 Mmp13 Mmp23 Mmp24 Mmp25 Mmp27 Mmp28 Bsg Mmp7 Mmp20 Mmp21 Mmp11 Mmp14 Mmp15 Mmp3 Mmp16 Mmp9 Mmp17 Timp3 Mmp19 Timp2 Mmp8 Timp4 Tcf20 Mmp10 Tnf Mmp2 Timp1 Mmp1a EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES%WIKIPATHWAYS_20260910%WP4349%MUS MUSCULUS Eicosanoid metabolism via cytochrome P450 monooxygenases Cyp2c29 Cyp2c38 Cyp2c39 Cyp4a12a Cyp4f14 Cyp2c37 Cyp2c23 Cyp4a12b Cyp4f3 Cyp2j5 Cyp4a10 Cyp2c54 Cyp2c40 Ppara Ephx2 Cyp2c55 METHYLATION%WIKIPATHWAYS_20260910%WP1247%MUS MUSCULUS Methylation Pnmt Inmt Comt Nnmt Mat2a Tpmt Hnmt Mat1a Mat2b CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260910%WP163%MUS MUSCULUS Cytoplasmic ribosomal proteins Rpl38 Rpl8 Rps23 Rpl39 Rpl9 Rpl7 Rps24 Rpl32 Rpl26 Rpl22 Rps4x Rpsa Rps6ka1 Rps6kb2 Rps15 Rps16 Rpl3 Rps17 Rps18 Rps15a Rps19 Rpl35 Rpl36 Rps27a Rpl19 Rps10 Rps12 Rpl31 Rpl11 Rpl30 Rpl34 Rpl12 Rpl36a Rps3a1 Rps8 Rps5 Rpl37a Rplp2 Rpl24 Rpl27 Rps14 Rpl28 Rpl29 Rpl21 Rps11 Rplp0 Rps13 Rplp1 Rpl13a Rps6ka2 Rpl18a Rpl13 Rpl15 Rpl17 Rpl18 Rpl10 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps26 Rps7 Rpl27a Rps21 Rpl41 Rps6 Rpl35a Fau Rpl23a Rpl4 Rps6ka3 Rpl6 Rps27 Rps28 Rps29 Rps20 Rpl37 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260910%WP386%MUS MUSCULUS Triacylglyceride synthesis Gnpat Mogat1 Mogat2 Agpat2 Plpp2 Agpat5 Lipe Gk Agps Gpd1 Agpat3 Agpat1 Lpl Plpp3 Pnpla2 Plpp1 Gk2 Dgat2 Gpam Dgat1 Agpat4 Lipc Lipf AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260910%WP1262%MUS MUSCULUS Aflatoxin B1 metabolism Gstt1 Gstm1 Akr7a2 Ephx1 Cyp1a2 REGULATION OF CARDIAC HYPERTROPHY BY MIR 208%WIKIPATHWAYS_20260910%WP1526%MUS MUSCULUS Regulation of cardiac hypertrophy by miR 208 Gata4 Mstn Gja5 Med13 Hopx Myh7 HYPERTROPHY MODEL%WIKIPATHWAYS_20260910%WP202%MUS MUSCULUS Hypertrophy model Hbegf Eif4e Ifng Myog Zeb1 Eif4ebp1 Adam10 Dusp14 Jund Wdr1 Ankrd1 Ifrd1 Ccn1 Nr4a3 Atf3 Mstn Il18 Il1a Vegfa Il1r1 P53 SIGNALING%WIKIPATHWAYS_20260910%WP2902%MUS MUSCULUS p53 signaling Rrm2b Pidd1 Gtse1 Cop1 Serpine1 Mdm4 Ppm1d Chek1 Chek2 Casp9 Casp3 Ccng1 Pten Trp53 Igf1 Cdk6 Cdk4 Cdk2 Mdm2 Trp73 Bid Atm Cdkn1a Sfn Atr Thbs1 Igfbp3 Cdk1 Gadd45b Rrm2 Gadd45a Bax Ccng2 Tsc2 Casp8 Perp Rchy1 Fas Pmaip1 Ccne1 Ccnd2 Ccne2 Cycs Ccnd3 Cyct Ccnd1 Zmat3 Bbc3 Cdkn2a Apaf1 Ddb2 Adgrb1 Serpinb5 Shisa5 Cd82 Ei24 Siah1b Ccnb2 Siah1a Ccnb3 Rprm Gadd45g Ccnb1 Sesn2 Sesn1 Sesn3 Steap3}