S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation 104923 70266 67870 67873 56369 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III 52637 246221 14718 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) 14417 14415 14645 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II 13075 13087 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 56473 54326 68801 74147 56348 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI 52815 GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation 110446 110460 93747 270076 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis 27053 PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation 111175 11671 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II 71707 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism 114663 228550 55980 320404 69718 19062 212111 320634 104015 16330 16331 16329 16332 233011 20975 17330 242291 101490 19211 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) 107869 12411 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 22247 69719 75533 56749 51797 110074 21915 55936 382985 18102 18103 79059 56520 54369 22169 66566 20135 66588 20133 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis 268566 SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis 216343 13195 21990 11298 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis 18194 15490 73166 98386 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis 56473 20216 233801 26458 272428 94180 328845 14081 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II 74157 234728 24018 67897 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis 23887 11687 17001 11684 14865 11689 625249 13479 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 68603 14593 110196 110446 319554 110460 15360 192156 100040592 17855 15357 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation 216456 14660 L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation 15233 234724 15445 14085 14874 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation 18948 12846 791260 26876 11669 17161 109731 11671 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II 245847 67980 26384 56174 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation 71761 108156 15109 243537 14317 NADH REPAIR%BIOCYC%PWY-6938 NADH repair 100043349 246703 URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) 64705 99586 103149 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds 18796 107650 18797 18798 103199 18799 72469 18795 18706 74769 18707 18711 18802 217837 74055 219024 114875 18717 27399 74302 84095 269437 104709 18803 228550 83493 234779 320404 76500 69718 72519 19062 75669 212111 327655 320634 75678 104015 320207 16330 18718 16331 52858 108083 16332 18704 233011 240752 20975 18705 17330 225326 18720 18719 19211 97287 67073 227399 18710 117150 271424 30955 18708 18709 224020 227733 269615 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation 212647 19125 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I 14651 109801 L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation 76282 108682 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA 68738 60525 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I 212503 228608 20229 69215 11754 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis 18478 ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing 11686 26569 320997 23801 545975 21816 433091 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis 107239 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis 22247 69719 56749 GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation 76952 22436 18950 14544 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation 20656 667310 12359 20657 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis 71780 114663 55980 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) 78330 68202 17716 17717 407790 17718 17719 17720 67003 22273 66694 100042918 67530 67273 70316 68198 66495 67130 75406 66416 68375 66108 104130 12858 66945 68342 12857 66377 17711 68197 227197 67184 100042503 17708 66046 17709 230075 17710 66916 67264 66218 54405 17991 66091 110323 66052 67680 66925 225887 100040287 12861 72900 239760 22272 66414 226646 624814 17995 17993 595136 623286 66445 17721 17722 12868 66142 12866 100041785 66152 17992 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis 227697 236082 57357 67422 52014 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 14450 68870 56248 108147 11565 100042069 23917 14923 11564 11566 231327 18103 237823 79059 78801 56520 67054 54369 11636 11637 229949 20135 635960 229363 20133 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) 69564 74080 226518 66454 225994 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt 14417 14415 14661 268860 214579 14645 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 66171 110208 14381 UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) 71365 71707 12850 56075 71883 217707 227683 52064 230027 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 100042069 23917 14923 18103 79059 56520 54369 20135 229363 20133 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis 108037 236539 100678 56433 20425 107272 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage 171567 14923 75533 18103 79059 13178 56520 27369 54369 18102 229949 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) 394434 13371 20887 13370 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation 216456 14660 27053 VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle 27973 69568 56316 18104 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I 107141 81906 13087 13078 13077 71519 74134 18984 20887 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation 11486 18950 GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I 23887 14862 14866 68312 76263 68396 16790 100042314 14863 14872 14871 14859 68214 56615 14874 211666 66447 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 108156 14450 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis 11689 16993 19225 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I 75986 242669 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II 12651 68671 99712 75320 28042 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis 107239 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 171567 75533 18103 79059 21915 56520 54369 22169 18102 66588 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis 11687 11684 625249 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) 23923 209027 19193 209692 12971 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) 77042 15586 74468 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis 22173 ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis 11972 108664 57423 66144 66290 11958 11957 11964 72325 11966 100039636 11947 66335 11973 11949 11974 230649 73834 17705 11946 114143 66043 11975 11950 100041835 432676 100039108 246782 228033 227112 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation 14287 270685 108037 108156 20425 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis 236539 100678 56433 107272 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I 104816 66514 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I 16365 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 231327 237823 14450 PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I 22245 68556 72269 80914 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis 74754 13360 235293 170738 14137 16987 14593 13595 110196 20775 319554 15360 192156 100040592 17855 15357 68603 18194 15490 73166 98386 110446 110460 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III 18263 11847 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation 72269 22271 76654 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis 15356 110446 15360 69772 71911 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation 68631 67880 58810 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis 18796 107650 18797 18798 18799 72469 18795 18802 74055 114875 18717 84095 269437 18803 234779 18718 52858 108083 18720 18719 67073 117150 224020 227733 269615 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV 68738 60525 11669 12359 11671 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) 13106 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation 12040 66885 12035 12036 15108 110446 13171 110460 13382 93747 12039 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis 11611 268782 ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 76267 56473 74559 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis 20450 20449 22234 14595 227671 14421 20440 54613 53625 14344 93961 14343 20451 57370 53418 20454 56375 108105 239559 26877 54218 26879 20444 56386 20443 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I 109778 394433 15369 15368 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III 27388 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis 56375 108105 56386 20443 20450 22234 14595 20440 54613 53625 20451 57370 53418 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 75540 234730 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 218138 THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III 29807 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation 64705 99586 103149 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation 66902 NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 192185 18115 CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation 110695 218865 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI 11534 PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis 12651 67420 68671 55979 12660 13026 14712 228061 99712 236899 75320 407243 28042 330450 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis 22173 L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 98256 71562 70789 266645 237320 107766 70266 209176 15930 23923 229905 56720 14719 209692 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) 13075 15490 13087 15487 15485 114664 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 74559 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation 211389 HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis 15186 GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis 20454 20449 22234 54218 14421 20440 20444 56386 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide 80908 26877 14344 93961 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III 11677 13106 67861 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis 11720 232087 108645 PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation 18606 68255 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis 171567 22247 69719 75533 56749 51797 55936 18102 18103 79059 56520 54369 22169 66588 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 69718 217837 75678 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis 108037 20425 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis 20249 171210 171281 171282 328035 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis 64292 67103 19223 19215 54486 77219 21391 15446 12408 100043508 19224 96979 19225 105349 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation 83493 72519 19062 320634 104015 16330 64436 16331 269180 16332 234515 234129 20975 101490 97287 19211 219024 74302 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis 106529 83603 56348 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) 71743 106564 66812 RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis 11687 11684 71932 11689 625249 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) 81906 13087 13106 71519 74134 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis 23887 64292 11687 67103 17001 19223 11684 19215 14865 54486 11689 77219 625249 21391 13479 15446 100043508 19224 96979 71932 72054 319446 13110 16993 106648 19225 56448 11688 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination 18602 18600 18599 18601 242726 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 18478 PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II 27388 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis 228550 320404 69718 19062 212111 320634 104015 16330 16331 16332 233011 20975 17330 19211 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis 76500 69718 227399 327655 75678 271424 27399 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism 107585 13371 13370 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway 50493 232223 26462 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis 11689 19225 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate 104112 KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis 67041 110446 69772 71911 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation 67689 66681 11670 72535 232449 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation 11687 11684 11689 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 12116 238505 64918 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation 107141 81906 13087 13078 13077 71519 74134 18984 20887 17161 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 266645 237320 209692 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions 14776 14775 67305 14782 625249 14778 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage 74080 226518 66454 59027 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation 76507 140483 CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis 67512 55979 110911 67216 102247 14792 74596 77582 14732 231510 52123 67469 28169 215456 68262 99010 225010 218121 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt 17330 12183 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III 338521 56794 11671 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis 14120 100043349 12183 14377 18655 21991 18663 68401 18648 56012 13806 18563 17449 17448 11676 14751 14121 13808 14447 13807 11674 230163 18534 14378 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I 237940 11669 17161 109731 11754 11671 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 66646 19895 21351 21881 VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II 106529 54325 56348 74559 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 76267 56473 20216 68801 233801 26458 56348 272428 94180 328845 14081 74559 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 69718 217837 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle 23887 68252 14630 66054 75475 14629 14854 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I 51797 55936 66566 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis 212032 15277 15275 110078 110095 19309 216019 66681 103988 232714 72157 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation 12040 268860 12035 227095 12036 66948 58875 13171 104776 13382 93747 12039 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) 231713 235606 67877 76773 11907 18203 56307 75624 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis 11689 19225 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis 76615 14718 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification 17766 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II 212032 15277 15275 216019 66681 103988 72157 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II 17161 TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II 98404 66078 68045 66637 76265 28088 104721 68215 67106 381802 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage 21877 22171 72269 13178 57813 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 75533 110074 21915 382985 18102 18103 79059 56520 54369 66566 20135 20133 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis 56454 69051 209027 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification 100042314 14859 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation 100042069 23917 107569 23959 230718 76952 11486 22436 18950 14544 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis 107869 11720 232087 269378 12411 108645 L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle 66902 11720 232087 104923 108645 20810 70266 67870 67873 56369 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation 20975 114663 242291 101490 55980 19062 212111 320634 104015 16330 16329 16332 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation 66885 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway 20481 218441 11480 12167 12168 12156 17128 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis 23887 17001 14865 11689 319446 13479 16993 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis 15497 15492 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis 14661 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II 19662 19659 22436 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis 14630 14629 14854 DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation 12846 17161 109731 11671 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis 11687 11684 71932 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I 76615 14718 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis 20454 53897 22239 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I 20322 PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate 16833 16828 16832 PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III 67689 11670 72535 11669 20229 17161 69215 109731 11671 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis 12716 12715 12709 76722 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) 60507 106248 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation 208982 15356 11992 72039 56357 12040 12035 12036 13171 13382 12039 78038 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle 14555 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation 104816 66514 11593 14718 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation 20887 11669 17161 11671 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis 11565 11564 11566 78801 11636 11637 229949 68870 635960 56248 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis 56360 70025 170789 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II 225845 66727 27281 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 98256 71562 70789 107766 209176 15930 56720 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis 67883 22235 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases 18796 18797 18798 18799 72469 18795 18802 74055 225845 66727 114875 27281 232889 18805 18806 269437 18778 18256 18803 26971 329502 234779 67452 271844 104759 237625 26970 665270 53357 26565 18783 18784 18782 18807 78390 66350 269615 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis 14137 20775 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis 78925 94224 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis 14630 14629 14854 14718 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis 71743 106564 66812 75735 211347 74450 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation 11676 69983 16548 225913 11674 21991 230163 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis 75456 19139 110639 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 22171 171567 75533 21915 18102 57813 21877 18103 79059 72269 13178 56520 54369 22169 66588 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis 12651 12660 13026 99712 236899 212862 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization 78914 74080 226518 98256 66454 58810 71562 70789 266645 237320 107766 209176 15930 56720 13195 209692 21990 11298 216343 13087 110446 110460 93747 20887 270076 11671 107141 81906 13078 13077 71519 74134 18984 11669 17161 109731 67375 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) 11430 113868 93732 20280 15107 15488 26458 74147 94180 15108 328845 93747 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine 58810 13195 109731 11671 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging 212679 70560 27267 23874 224805 71984 226414 85305 97541 70791 22375 216443 234734 107271 20226 15115 105148 68915 230577 226539 69955 71941 381314 107508 102436 67417 109093 110960 70223 22321 353172 66590 272396 71807 244141 104458 70120 107045 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage 216134 103711 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I 245847 67980 26384 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis 234724 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage 171567 75533 382985 18102 18950 11486 68870 56248 11821 15452 11565 100042069 23917 14923 11564 11566 18103 79059 11534 78801 56520 54369 11636 11637 229949 20135 635960 229363 20133 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) 93898 70750 104725 20773 13244 268656 228677 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 22171 171567 75533 21915 382985 18102 18103 79059 320685 56520 54369 66566 20135 20133 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis 171567 75533 51797 18103 79059 56520 55936 54369 22169 18102 66588 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine 108037 110695 20425 218865 74129 12116 TCA CYCLE%BIOCYC%PWY66-398 TCA cycle 20916 20917 11429 67834 18293 13382 66052 67680 66925 17449 17448 66945 170718 14194 78920 12974 15929 56451 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis 68327 14791 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation 20280 15107 52538 26458 13177 231086 94180 15108 97212 328845 93747 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis 93898 70750 104725 20773 13244 268656 228677 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) 74559 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II 20322 11522 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis 20454 108105 22234 26877 20440 56386 14344 93961 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation 257635 TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling 72562 13180 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis 20810 TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis 14528 20751 19286 L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) 98256 71562 70789 266645 237320 107766 209176 15930 56720 209692 110446 110460 93747 270076 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation 108155 76055 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis 15159 RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I 19662 19659 19378 11668 242285 216454 56847 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 20450 80908 14595 20443 76969 14348 14343 57370 53418 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation 171567 75533 18103 79059 56520 54369 22169 18102 66588 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation 72269 64705 99586 22271 103149 76654 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) 107585 13371 13370 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis 14595 53625 72077 14538 57370 53418 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) 13177 23986 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis 100043349 103988 212032 15277 15275 216019 18642 18770 56421 18746 18641 12183 18655 21991 18663 18648 56012 13806 11676 14751 13808 14447 13807 11674 230163 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) 107869 12411 HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis 56375 16770 14595 50935 20440 53625 14344 93961 72077 53418 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation 100042069 23917 23959 76952 22436 18950 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 22275 14151 19044 12892 MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle 78070 12896 57279 12895 12894 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis 22178 13190 22173 22063 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) 71147 223722 257633 70316 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation 14073 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) 11532 13885 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis 22234 239559 227671 26879 20444 56386 14344 93961 14343 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation 212032 15277 15275 58866 103988 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis 71932 13850 384214 13849 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) 77974 19771 19662 235033 19659 17252 241452 19892 20148 79235 98711 19660 19682 19661 28200 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis 15497 78925 94224 13074 15487 105349 15492 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis 100042069 171567 23917 14923 75533 18103 79059 56520 54369 18102 229363 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis 77974 19662 235033 19659 17252 241452 20148 79235 98711 15450 104158 67935 234677 63857 436059 69060 19660 28200 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis 11687 11684 71932 11689 625249 19225 56448 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis 107650 103199 18706 74769 18707 18711 18717 84095 104709 83493 75669 320207 52858 108083 18704 240752 18705 225326 18720 18719 67073 18710 30955 18708 18709 224020 227733 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II 212032 107652 15277 67980 74246 15275 26384 109785 54342 216019 14751 103988 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I 268860 214579 CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis 216019 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I 12583 14718 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis 170439 26458 70025 56348 94180 328845 14081 171210 171281 171282 74559 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation 268860 TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation 212647 56189 67432 14719 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation 106648 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 56473 54326 68801 56348 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis 16987 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 56632 67103 26458 94180 433323 328845 171168 14081 81535 54447 230379 11886 20698 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 66681 11486 18950 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation 72962 72269 22271 76654 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism 18796 269437 18803 234779 72519 18718 18797 18798 18799 72469 18795 97287 18802 117150 74055 219024 114875 74302 269615 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis 77337 83702 78925 94224 105349 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis 671878 FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I 270685 108037 108156 216188 17769 20425 107747 665563 17768 100039707 238505 GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation 14626 14933 235533 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation 110119 L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation 11720 232087 269378 108645 ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III 15452 11486 18950 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation 69590 14776 75512 14775 67305 20656 667310 12359 14780 14778 20657 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation 107569 23959 230718 76952 11486 22436 18950 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) 81906 13087 13106 67861 71519 74134 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis 56752 170442 192289 20425 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) 228550 320404 69718 19062 212111 320634 75678 104015 16330 16331 16332 233011 20975 217837 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis 11687 11684 11689 625249 11688 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation 69060 18947 16891 231871 16956 67717 15450 16890 116939 12613 66853 269060 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) 94181 12764 50798 67311 CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis 74451 66586 66461 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation 12846 CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis 14431 67092 UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) 22235 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis 270198 319801 18639 18640 170768 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis 14593 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) 22171 108037 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 78914 74080 226518 66454 67375 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis 70383 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I 24018 67897 DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis 12408 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I 19210 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 56473 54326 68801 56348 74559 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I 74246 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) 20450 14595 20440 53625 20443 72077 14538 57370 240119 53418 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III 13106 68738 60525 11669 11671 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II 68738 60525 11669 11671 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation 66904 17850 73724 110821 12040 13171 13382 12039 LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III 226413 12091 70893 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV 81906 13087 71519 14262 74134 55990 11761 14263 394433 226564 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) 74246 66681 319625 14430 14635 72157 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II 212032 14584 107652 15277 15275 109785 54342 216019 14751 103988 14583 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis 76282 108682 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis 11564 67054 108147 L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) 30956 110695 23923 209692 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis 214580 20768 109079 20226 211006 71984 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation 117147 26458 16922 56794 11671 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis 14645 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis 14593 110196 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis 68591 WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis 100929 329504 209584 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I 18778 18606 66727 27281 242864 56209 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation 66885 117147 110446 110460 93747 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis 78914 74080 98256 226518 71562 66454 70789 107766 209176 15930 56720 67375 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation 26458 94180 328845 14081 74205 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) 22117 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis 114874 18795 231871 269060 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) 11832 20531 64008 20516 20515 67768 20525 67674 18950 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation 81906 13087 71519 74134 13088 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation 11532 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I 66681 216558 72157 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis 11689 16993 19225 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis 56454 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation 23972 23971 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis 331026 14751 29858 54128 110119 69080 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 UREA CYCLE%BIOCYC%PWY-4984 urea cycle 11898 109900 227231 18416 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) 108037 20425 74129 12116 SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) 211389 59010 22117 HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis 22275 17025 14151 11655 19044 11656 12892 15288 22276 PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I 66904 17850 73724 110821 L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation 12040 13171 13382 231691 257635 12039 GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage 15452 18950 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle 11898 109900 18126 18127 18125 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation 12040 13171 13382 12116 12039 238505 14718 64918 211389 66904 17850 73724 110821 11720 107869 12583 232087 269378 12411 108645 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis 17025 11655 11656 15288 22276 MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway 68603 110446 319554 110460 15360 192156 100040592 17855 15357 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II 211488 106564 14261 ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) 93692 14873 DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis 55979 67916 216152 13350 19012 231510 50784 52123 67800 67469 68393 28169 381925 215456 229791 68262 235044 99010 225010 218121 67512 67216 102247 14792 77582 14732 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis 54391 319945 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 17330 69718 217837 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis 13166 18948 13195 21823 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 100929 209584 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I 246277 12583 14261 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I 11821 MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 17449 17448 14718 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor 75788 12393 76630 19877 17977 72183 18519 15529 18744 12447 57258 17222 16478 66313 20481 20482 56440 12530 67804 20682 20692 56484 20742 26409 21417 21781 211586 26413 21808 26417 21809 21812 26419 21813 216080 100041766 66105 22337 26416 103573 76793 227720 75465 67068 54709 52563 217232 69150 11909 69957 14106 12234 12442 230597 12505 24136 218210 56458 26399 21803 21814 18751 18752 17869 12928 11651 216869 11835 11848 26397 11910 19650 19651 17126 17127 18708 18709 12927 18753 14083 12566 20869 22062 22059 12387 13163 328572 13982 13132 71770 16842 433759 21402 15481 26965 16476 15239 17128 56438 68015 12567 12571 12575 68999 22601 66513 13018 26754 20901 218441 26411 71728 12534 12914 386655 19303 104394 14281 13559 13805 19645 23871 12443 14030 54601 14225 269338 14272 14282 20683 97064 12189 272359 99152 52206 15378 15405 69260 21815 16477 16211 17130 17131 17258 17260 12705 18044 18045 18046 18102 56513 56371 59008 56317 228026 18854 19042 71978 19085 19087 75901 12389 BDNF%IOB%BDNF BDNF 18212 26419 18803 23939 56637 26420 110157 16367 20416 13712 19229 271849 384783 18211 56484 26413 26417 11651 CCR1%IOB%CCR1 CCR1 26416 19229 18753 12913 14083 12768 18033 19697 19303 20302 20303 20304 20306 20846 22637 14675 20779 26413 26417 LEPTIN%IOB%LEPTIN Leptin 16367 384783 54611 18754 26413 20528 13649 26417 20218 16452 14784 20683 20848 667739 17979 19247 16453 192157 26416 16410 16419 16846 18708 16847 18709 18753 14083 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin 20848 56484 20416 233871 26413 17480 14388 26417 20851 16452 26395 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor 19273 71520 15461 67296 114715 114716 14936 16197 20662 56150 17179 17311 17342 21682 215280 22612 21933 54607 16590 56468 67300 15162 12703 20850 12984 14159 14191 26413 17096 12928 11651 26419 26416 18708 18709 11909 328572 16476 18751 18803 56637 110157 20416 19697 20846 20779 16452 14784 667739 19247 16453 20851 12929 13448 13685 56717 16331 13857 11350 14360 218397 14786 20111 18706 22376 58194 12402 208650 18750 CCR7%IOB%CCR7 CCR7 26419 12631 18803 56637 26416 19229 19697 56717 56484 56458 26413 12775 26417 11555 100039973 11651 100038965 WNT%IOB%WNT Wnt 22612 26409 11651 216869 26419 18504 19045 11848 18099 23988 22417 19052 18747 84095 320790 77578 20377 20319 18753 20664 22408 22413 22415 22418 22421 12387 14367 14365 12005 14362 14366 93687 16842 14368 21413 14369 14370 14371 16476 18751 18719 18752 84035 330938 21416 22416 84505 56637 12571 606496 19353 16480 54401 226970 13016 17125 13728 13542 13543 13544 13380 208846 67943 20378 231103 14734 192199 11789 12550 12443 16202 16971 16974 16973 18019 26563 26564 18750 FAS%IOB%FAS Fas 224105 50873 12362 320795 19877 11746 19090 12369 19106 66593 12370 72322 12028 12048 19687 20230 12122 12169 20807 56274 58231 12229 21454 12537 21841 21843 22029 22030 22031 26413 74153 22390 26417 12380 12366 12363 12368 223255 26430 56041 100042807 192656 14082 12633 17999 17193 26926 21945 98488 217232 26885 15170 16818 109333 56637 26395 14360 218397 17096 11651 18753 13163 93687 19353 26396 12043 17295 18810 22352 12367 11545 12371 19766 15507 333883 18570 19192 63958 66587 14084 27373 100039026 13001 67379 13347 21969 13665 75705 93692 11798 14102 14103 11857 17187 26408 15235 101706 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 22612 11651 11835 11848 17126 17127 18708 18709 18753 14083 22062 100039786 23844 12821 109620 13684 13844 13866 55948 16403 192897 16418 16773 16774 16776 16777 16779 16780 226519 16782 16785 19353 16367 19882 18479 20416 54401 74769 18707 30955 59079 384783 12015 20166 22627 22629 22631 18710 213435 18208 12476 20779 13649 14784 17295 18810 19247 22352 12367 13685 56717 11350 14360 18706 18750 NGF%IOB%NGF NGF 12912 327826 18759 13712 83945 26413 26417 26395 20683 HEDGEHOG%IOB%HEDGEHOG Hedgehog 22627 13363 24069 19014 75050 19206 15245 20423 319757 216869 19207 117606 70208 59024 110355 13548 18747 69792 264064 100041953 14451 269209 14632 14633 14634 16147 12387 GM-CSF%IOB%GM-CSF GM-CSF 12934 12465 14376 14827 59013 12051 20525 20740 22350 22612 15162 20850 12984 14159 26413 17096 26417 11651 26419 26397 26416 18708 18709 12927 15170 26399 21803 21814 18803 56637 606496 26420 110157 20416 13712 12015 19303 12912 20846 16452 14784 26396 20848 14388 20851 26395 12929 23921 19264 20112 22324 56324 14694 20844 57320 12675 16150 18643 18035 11757 12402 12981 20963 18750 12982 CCR9%IOB%CCR9 CCR9 26419 56637 26416 22350 225825 12769 16401 16421 17698 19684 20300 17123 12550 56458 26413 26417 11651 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 110157 26416 18479 20416 13712 14083 20851 26395 12169 18127 17973 13449 21687 21846 20850 14786 14159 26413 26417 11651 26396 CCR5%IOB%CCR5 CCR5 19229 19697 20303 20304 20306 20846 12774 11576 20850 26442 20293 20292 26413 20296 12273 26417 12504 11651 14784 20848 12631 26416 18708 15170 12675 16150 18035 20963 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha 16367 384783 20846 22637 20850 12928 20847 11651 226652 20848 20849 667739 15975 15976 26397 18783 18761 26398 20852 16451 13867 73086 54721 18753 20851 12929 13685 56717 22324 75705 56458 26399 18035 12402 TRAIL%IOB%TRAIL TRAIL 12362 19090 12369 66593 12370 12028 12122 18033 19697 21933 12912 26409 20779 22030 26413 26417 11651 12366 12367 11545 26416 14082 19766 12633 16151 26926 71609 50883 13030 12070 100039026 15270 11783 12387 27056 17210 11920 18383 670717 12018 11798 22333 65111 22035 18035 12042 105787 12402 NOTCH%IOB%NOTCH Notch 18519 26413 26417 17127 328572 16842 433759 21402 26965 15205 21423 11820 17128 20602 56438 13389 16449 14357 56637 14199 16396 56381 59287 15213 140484 13388 17125 15182 19664 16450 16848 18033 17305 19697 18128 18129 18131 18132 18133 20466 18550 100039623 54485 50754 55927 433586 100042305 19164 16452 19165 16656 20848 19763 27401 21885 22632 208117 270118 18222 60406 66935 20185 103806 M-CSF%IOB%M-CSF M-CSF 20416 12370 19229 17342 20850 11651 14784 20848 19247 22352 14082 19766 18708 210710 12977 18753 12978 20851 14083 23872 360013 209446 19201 17444 16331 13429 16332 12402 EGFR1%IOB%EGFR1 EGFR1 12390 56455 109711 54366 11502 101320 29875 54126 22687 19134 73178 29806 208177 68481 53859 12702 232431 54132 13549 194590 66952 23942 14924 21873 225870 20970 98910 238130 17775 330914 26431 78388 50926 12928 11651 11848 26397 17126 17127 18708 18709 12927 18753 14083 12566 20869 22059 13132 71770 433759 16476 15239 218441 12534 19303 14281 20683 21815 12389 16478 26413 26417 26419 26416 56458 18751 18752 17869 18803 23939 56637 26420 110157 20416 13712 19229 384783 18033 19697 20846 20779 13649 20218 16452 14784 20848 19247 14388 20851 26395 12929 13448 13685 56717 11350 14360 218397 14786 20111 18706 58194 12402 208650 18750 15461 20662 16590 67300 12703 20850 17096 12631 606496 19353 16480 54401 226970 13016 12550 26396 12043 17295 18810 22352 12371 19766 333883 11746 17999 15170 16818 109333 12821 109620 13844 13866 192897 18479 74769 18707 30955 59079 12015 22631 18710 12912 327826 18759 110355 13548 20112 22324 56324 20844 18643 18127 17973 13449 20847 16451 13867 73086 54721 105787 11820 16396 13429 16332 229615 12606 72993 227753 18760 19211 234779 100040260 20971 22325 12558 11308 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 12568 14251 74326 236576 24063 24064 57783 21787 67938 57257 108100 12608 24105 20499 26405 229709 19765 20867 399510 56460 69710 232910 12757 73379 19261 12988 216810 13014 12388 218518 74256 244418 11771 13205 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 13860 13858 11657 11674 240753 13855 229285 26936 286940 14252 98432 224650 23943 209039 105782 22378 80794 14302 235406 228136 104831 20399 19253 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 232906 26934 11740 13854 16952 12306 15194 215114 15382 628438 11804 16337 16400 16412 11836 67859 11843 110308 16687 110310 16691 16667 16668 16828 11855 16835 210126 109904 26401 26406 26407 17709 17886 17920 18003 11928 23980 50932 20403 13196 11949 67941 50766 72621 18596 54135 72201 18607 11431 18648 240752 18738 18746 67451 18805 18806 22038 74155 67760 54473 109135 171463 212139 71889 216190 235542 74255 170643 321022 230837 108079 19084 26362 18762 66898 23938 26400 19108 208618 93742 66166 76179 140721 20459 19246 19248 19262 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 666899 667618 667279 110651 67097 20194 20195 20239 394252 20969 53378 140579 71514 56726 20404 20408 230126 319939 381126 114479 20617 107686 20663 109552 109880 20909 11491 22042 21881 21894 21961 22051 22323 22330 108705 66395 244895 640703 60595 24066 319152 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 72828 227937 107435 30794 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor 12393 12362 17977 12369 18519 12370 12447 12530 12537 56705 12572 107951 56424 17978 81601 108767 12539 217127 13144 56710 13195 14797 11622 104156 14200 56406 192176 56218 14375 30051 68098 75273 11739 98053 68705 14884 223870 19183 15375 15469 14828 15519 16195 56637 11863 75352 17246 53610 18813 18477 57314 59004 18986 101700 214230 328365 12017 57782 19697 170758 19384 19822 18193 77627 225115 21804 20779 232286 22025 22026 22027 13649 22196 22353 107823 22596 20848 22668 627557 12317 17979 268903 52915 22294 23957 56469 12445 66671 107321 56736 12531 14694 57320 11651 11835 19045 17127 18708 12387 13163 328572 13982 433759 21413 15481 16476 17128 20602 19303 20466 19645 12443 20683 12189 12367 11545 15507 21815 21969 229615 12606 72993 227753 18760 19211 12389 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 20848 14388 14255 14389 11909 12912 12606 20850 26413 17096 100040260 26417 12402 16476 208650 11651 CD40%IOB%CD40 CD40 26419 20848 26420 16453 26416 18708 26395 16818 14360 12675 16150 14191 26413 17096 234779 18035 26417 16476 20963 11651 17869 TNFSF3%IOB%TNFSF3 TNFSF3 19698 18033 18034 19697 21937 21938 22033 16992 17000 16994 22030 22031 18035 16476 ID%IOB%ID ID 21416 11910 19650 19651 13712 17127 12566 19645 13713 13714 15901 15902 15903 15904 17877 15205 17927 18507 21423 19185 G-CSF%IOB%G-CSF G-CSF 12576 12700 12985 12986 14319 16188 18778 19696 20416 667310 20977 107939 12702 20846 15162 20850 18759 26413 17096 26417 16452 11651 14784 20848 19247 26416 16451 54721 20851 14389 12566 27373 16818 16331 20111 12402 20963 EPO%IOB%EPO EPO 606496 110157 15163 384783 20393 12015 319183 18127 56484 20850 54601 26413 26417 16452 11651 26396 109880 20848 19247 73086 14388 20851 26395 12929 23921 56717 22324 13857 56458 16476 20963 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma 110157 15395 15900 15979 16362 16363 19094 20375 20846 12608 20850 26413 13649 26417 12928 16452 11651 26419 20848 18783 18761 26416 20852 16451 12929 234779 12402 TNFSF1%IOB%TNFSF1 TNFSF1 16151 19698 18033 18034 19697 21937 21938 22033 16992 17000 230979 22031 18035 16476 11651 TNFALPHA%IOB%TNFALPHA TNFalpha 320795 12369 12370 53859 12122 22029 22030 22031 12366 107951 14082 12539 12633 56710 100039786 192176 15519 22627 22629 22631 12912 22026 22196 19698 18034 21937 21938 22033 14694 12675 16150 18035 20963 12051 19696 14886 11797 15516 16535 100039592 16648 16709 17218 17220 11651 26403 76784 18036 18037 20018 18567 18616 18637 245841 100043714 67857 73086 19173 19179 16151 19181 18753 71609 19182 70247 21762 22123 17463 66997 23997 228775 19708 77045 67891 432502 27207 433759 57751 21402 80859 27215 26965 64424 16476 20586 20587 20588 68094 57376 21926 21929 22034 22628 22682 66513 231130 236733 26754 20017 224619 15182 18201 230233 26572 56456 12914 12905 21934 12455 70834 233406 53376 17164 19645 211550 50797 21941 50754 226525 67384 20016 22032 56489 73174 66413 23881 227648 216150 21353 15185 72416 71833 56399 544963 333654 18789 56532 26410 446099 17846 109658 11652 14113 211651 76589 19414 14229 68652 103583 18854 16650 11647 66724 20019 56407 56312 12389 12091 20340 71966 69721 56480 26409 26405 26413 26417 26419 100041766 66105 26416 13205 12234 26399 26420 18033 19697 20846 20779 13649 19247 14388 13448 26401 26406 20850 18762 23938 666899 54401 13728 12367 19766 15507 14084 100039026 GDNF%IOB%GDNF GDNF 17295 19713 21823 110157 12532 19229 110651 12927 14388 14083 12534 26395 13448 19303 14360 18035 16476 12928 26396 TNFSF8%IOB%TNFSF8 TNFSF8 18034 19697 12051 19696 22029 21941 26413 22031 19698 11651 18033 CXCR4%IOB%CXCR4 CXCR4 14674 13983 23880 14677 26385 15894 16414 16428 16822 16885 12778 17973 20315 21785 22329 12767 56484 59025 12774 26413 17096 26417 12928 20847 216869 20849 12631 11848 26397 18708 18709 12927 18753 14083 15170 16818 15481 18803 56637 19353 54401 13712 19229 12015 18033 19697 19303 12912 20846 22637 20779 13649 16452 26396 20848 667739 19247 16453 20851 26395 12929 13448 19264 20112 16331 22324 14360 218397 12675 16150 22376 18035 234779 100040260 20971 12402 22325 208650 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 18747 19225 18021 54720 16476 640703 56398 18018 18019 14281 104248 12981 16184 16183 15978 14103 53901 21947 381319 18986 14283 238276 14225 16477 16189 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 16476 20687 18519 12912 328572 17131 20466 14462 12567 226519 12566 228839 17869 15481 14815 20683 17977 75901 245688 19650 17978 14106 56484 17260 56458 16419 12579 21815 15378 13390 14836 60406 16191 12575 11835 12914 11909 17927 11651 15228 20467 20482 22337 20481 21781 13982 18091 15182 433759 13559 76793 104394 21423 15977 12843 94112 59004 17187 54601 14534 18787 17126 17127 17128 100041953 20185 12608 209446 22642 19646 12393 13016 11910 12399 16153 12400 54123 12705 229615 14281 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 16173 16171 257630 18033 18035 20846 21926 17523 20849 20848 209590 329244 12702 93672 16452 16182 83430 16176 16400 20293 18126 16174 12501 54721 17329 18708 19697 16161 16160 18706 11686 16193 12504 16183 330122 15978 20850 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 433759 56469 103573 208727 22196 19384 17344 17246 19386 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 20750 18720 53859 16202 16476 57257 26419 19353 16416 26413 19878 26417 19229 11848 12505 12675 16410 17390 26401 18792 17395 227753 18033 18035 18708 19697 14281 18706 12927 20963 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 17128 26413 17131 26417 21813 13001 17129 21803 55994 11477 11480 12389 11481 12168 11482 17125 19045 13805 15901 21909 12165 16323 216869 21809 21812 14225 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 18747 218397 16367 20779 14083 16476 76829 26419 19353 12912 26413 26417 11848 17973 19247 20662 18708 15461 14573 14783 14786 18706 13448 14784 623279 12928 58234 18750 19713 14388 384783 20416 327826 19303 109905 12927 14585 114255 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 18747 20969 12833 12832 26413 12215 12815 26417 12814 12831 94216 12830 83995 17393 15234 12361 20304 17395 14170 17295 12829 12828 12826 21803 12825 12824 64654 15442 12842 19035 16776 53378 14186 12836 12835 14184 12834 12843 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 218397 18754 240057 18176 16854 240168 56715 18015 640703 20662 18751 15461 54153 19395 12323 16852 225870 14784 18762 233046 74055 69601 18750 20663 20130 19415 19419 114713 19417 19418 16653 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 16319 20877 625328 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 12703 20292 16186 16451 16453 12048 16416 15361 16165 16164 16992 15170 17863 16331 17864 20295 14159 11687 16190 20683 23871 56717 12053 18703 13449 16364 26416 245195 20344 20375 13654 18390 14128 21786 56468 21838 11846 16191 66596 11628 20851 12402 547253 20852 11651 14784 384783 12843 20416 16367 12608 16153 12842 12702 16452 18708 18706 20850 21947 16189 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 16186 16451 16453 19353 12048 17863 17869 56717 18033 56484 11651 15519 19247 16185 640703 20662 667739 18708 20597 19697 12043 16818 13669 18706 21752 14784 18762 22234 16184 208449 16183 14389 13555 20416 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 18747 16186 16451 16453 11848 19247 16185 20662 15461 16818 14784 14389 232906 16001 14388 16000 107971 20416 18127 327826 18049 21687 18591 16911 16195 16194 16367 11600 22339 14677 15979 13645 18205 78405 18596 17356 94212 13649 15529 16542 110157 18211 18212 18213 14679 12064 26395 26396 20846 16452 18176 18708 18706 16193 16184 16183 15978 16653 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 54720 20185 328572 12393 13016 17863 16542 17977 225182 14465 108058 14463 15251 103806 20602 20848 56381 22160 11545 12576 15214 16452 18128 11863 17172 22632 19645 11835 21885 12914 15205 19213 17927 14600 99982 14387 19664 14460 55927 15213 270118 11925 12504 433759 13555 21423 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 109700 16420 16398 16421 241226 16411 213119 16416 16412 16414 16410 16419 16400 104099 381924 16407 16408 16409 16399 320910 16401 16403 16402 16404 319480 192897 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 16319 19046 19878 18817 228730 236930 11848 17931 20878 22390 19324 218294 269582 229841 72119 103733 99412 67141 107995 72415 20843 12531 67629 13605 12532 12235 56371 12234 16563 19348 19052 51792 100043703 18479 74498 78177 233406 71876 103583 67052 12534 18221 77744 12236 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 19090 17535 22195 18538 27354 22059 235559 100040608 12021 72775 19361 12566 225182 66105 22596 211651 14088 14087 14030 67030 11920 14375 12189 67337 60534 12447 19360 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 14679 14677 14687 94226 11848 14673 14681 14678 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 20779 12912 18211 55948 54401 18753 22065 193034 216439 12015 12443 18803 12326 56484 13653 12322 100039786 22628 22627 22631 22629 18607 56637 18176 11651 20662 18708 15461 18706 14784 20850 14388 20416 18049 16653 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 16476 26419 16173 21803 20849 20848 16182 14969 14968 57765 12500 12502 12914 16362 16174 12503 12501 18646 16163 104156 12487 12519 12524 14281 26420 16184 12504 16183 15978 17344 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 218397 16319 18148 22352 23980 215387 67455 71819 16765 19047 28114 21770 107589 242521 11848 20878 72415 12235 19348 67052 26554 70099 19167 14211 12419 11799 52276 54204 26934 12615 13346 320165 14020 20877 68298 625328 73804 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 20779 14083 19353 26413 26417 11848 18208 17909 69635 13176 330662 107449 14360 22612 26395 107448 216439 26396 73178 18738 17755 18803 22253 140580 223435 12322 18479 17973 18708 18706 12927 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 14677 26413 26417 14687 11848 94226 14673 14681 14678 14679 18803 13611 14674 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 26395 26413 30955 18576 104709 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 19225 328572 20466 14462 17863 17869 15481 20683 23871 20375 18712 68652 11906 11486 545878 12575 12490 17217 12914 67155 17311 17927 12418 17120 12571 21426 15461 17132 12043 14863 20481 56463 12757 19374 16841 19152 12346 66513 12368 232087 18507 26409 12843 22761 17878 12578 16842 23872 67738 16790 15258 67972 11796 12978 20185 16590 12608 12847 11541 19208 51788 50701 12427 21849 18099 29875 18674 64050 19055 229615 12609 12606 22408 12443 17523 12576 18176 15205 14460 12504 22196 16653 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 218397 20779 14083 19353 26413 26417 26395 13845 73178 13844 270190 22041 104015 13429 215449 13643 13642 13641 13640 16443 26921 545156 19877 13846 18176 18479 17973 18708 15461 14786 18706 14784 12928 20130 20416 19303 109905 16653 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 20779 11796 26419 12675 26401 26416 18607 14082 19687 12229 14102 67300 11651 12122 12367 22350 18708 20597 16150 72393 74769 26420 26399 18706 26400 12370 16151 19766 19094 14103 11797 26414 12633 20963 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 20873 20620 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 16706 21937 114774 11796 67384 18590 26419 13645 228355 229317 26926 26413 12028 58994 26417 18201 11886 26398 13033 110157 670717 12905 17869 26401 18753 26395 26396 18033 12015 18035 21926 26921 14082 19645 11651 12122 20597 19697 12043 18762 12370 19766 16000 56632 71609 22030 23992 19106 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 20779 22195 21770 19229 14773 21823 18796 18753 14360 17096 22612 19144 15162 50873 12015 12143 30931 67847 57320 22223 13162 56424 100039026 14191 20617 18805 18806 109731 16818 14225 20963 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 12234 20779 12051 19696 216869 18708 16150 19697 16818 18706 18033 18035 26416 20963 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 26397 18720 16476 26419 16412 19878 11848 26398 17931 12576 18805 18806 19877 105243 320795 109333 11909 20404 320271 14064 22350 18719 20807 22330 20544 14281 26399 56513 11459 18762 29857 21894 12631 16007 223701 19211 18717 19684 17698 13367 17906 16885 12704 16886 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 16416 11848 14360 22612 17096 15162 12143 12389 14191 20851 11651 16818 13448 14784 12928 20416 18591 16367 12977 20779 64177 19246 12978 12991 13645 12988 14131 12333 18596 50490 19116 24064 13649 16334 16846 16847 16797 19109 14158 22166 16337 12558 22608 20848 12702 16452 54721 18708 18706 20850 16399 12927 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 18747 218397 20779 16398 26419 16412 26413 12028 26417 11848 15529 17390 12361 18753 14170 385643 13844 14268 60409 16774 21803 57916 269587 64654 16772 12390 14694 53378 14186 14184 18015 12367 22350 15461 12981 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 13712 320139 18176 26413 26417 18751 15461 110157 14281 26395 18750 16653 26410 109880 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 16476 26419 12048 12912 328572 26413 26417 12567 17390 21823 18792 26416 11846 11909 12043 13982 18750 12189 16334 11910 12400 12443 12702 20724 21808 83430 20174 18218 19017 19645 63953 18126 18595 15205 26914 20339 18015 16478 81703 13008 15132 12123 14281 26420 12428 26554 71355 81601 16193 19252 240672 15978 19094 13198 11423 13197 18986 16477 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 13838 13837 20779 13835 13637 57257 13636 53972 13836 13638 11848 14360 17096 22612 15162 12143 18803 30955 104709 13640 14191 19877 12402 16818 12928 442801 12568 12929 13842 13840 22325 13841 13839 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 18747 21937 18519 328572 68346 17131 75387 20466 14461 27374 56233 15185 23942 15184 30795 64384 75788 70465 93759 216848 245688 232232 19016 17191 107932 64383 21422 22025 170787 229512 70315 50721 12234 209011 234366 60406 17119 79221 15183 229542 12914 17192 20467 15182 433759 22761 17187 100041953 20185 19646 18033 18035 21926 20602 20848 22632 19697 14460 103573 208727 22196 19384 19386 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 109700 24044 18102 16398 105504 20528 241226 211446 213119 16412 16334 16410 18805 18806 16400 216859 67300 211914 12876 53413 70834 22319 30948 11555 12000 12387 20336 104099 30957 69940 12550 56044 107371 18717 16593 22095 16401 12385 16403 11845 16402 11607 16404 12388 319480 66482 13430 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 26419 93687 18519 27401 214897 328572 64143 19651 18817 12359 20393 20656 15235 12566 12675 252870 14377 55948 22682 54401 67731 12125 70425 93759 103236 12053 27373 104318 56484 56458 100039786 22628 22627 22631 12576 22629 12914 11651 16150 26420 12387 14103 56044 103573 26414 13197 19384 54601 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 13609 14676 14677 14687 94226 14673 14681 14678 14679 14675 17250 81535 14739 13611 56632 14672 14674 14682 20397 20698 13610 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 18747 19090 20779 20528 12048 12675 110157 55948 54401 56717 12015 56484 56458 100039786 22628 22627 22631 12576 22629 18607 210789 56637 78757 16646 56716 12575 606496 12371 23797 227743 11651 15519 11652 26408 54601 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 18102 20779 16421 19353 17356 11848 29875 12443 215449 11651 21872 18708 76884 107746 11767 13383 18706 12387 242687 21844 226541 12928 16480 16407 12550 13043 50884 11308 18717 12385 11845 109905 22325 12388 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 319757 110355 226861 21808 20423 19227 14451 13363 14633 216869 19206 11651 18708 18706 57810 16976 15245 117606 19207 14725 20460 16147 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 20873 12795 18817 20620 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 18720 16476 26419 19353 68089 67771 26398 26403 11867 56378 66713 74117 26401 11855 224105 18796 13058 241275 192662 13057 108100 101314 26416 17970 76709 83767 329165 71893 17969 237038 404710 18479 11909 18719 12387 12928 12631 12550 18717 12385 16885 26397 29875 20848 76884 26420 26399 26400 242687 20850 50884 11308 26934 12927 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 14686 12790 76376 19682 245650 243923 14695 77974 30952 78600 14697 170735 107477 14913 24013 19892 19739 79235 110855 14710 14919 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 14163 18102 20403 73341 227377 57257 109904 53972 219140 319899 216963 75974 11789 192662 18803 16443 70497 210293 236915 26934 29815 54126 19765 52666 22325 71972 228359 17207 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 18787 22339 13636 328572 14254 17387 67923 18655 16542 112407 112406 20525 26357 11792 22346 20683 23871 16341 93759 20893 18999 17684 18174 13856 13819 14297 319594 11540 22160 13712 11863 12914 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 16476 26419 18519 328572 14461 26398 56233 14815 17977 93759 17978 26416 56458 22025 19696 11835 12914 67155 320795 15519 433759 20779 12606 13653 14694 20588 11614 52915 217127 59035 56637 21848 18585 30051 20181 20183 20182 223870 22026 66884 57376 50528 15408 110147 26399 68098 15502 81601 18986 17246 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 13712 16451 16476 18595 20662 18708 20807 107746 16410 14281 18706 230126 14784 435684 12391 12928 18803 12929 20416 12389 100039026 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 14186 20779 14184 13649 12361 14360 14170 20970 13043 18976 19164 11604 17202 100042305 64654 13004 59287 19242 208117 100039623 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 22278 100040260 19225 102626 271457 73389 16476 17165 22059 12608 18783 12912 17164 15507 13714 14567 17346 17258 13685 16691 13684 17342 56613 226641 73086 26416 17260 19017 18126 11909 20544 13982 19094 13198 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 18747 20750 20779 14083 19353 16412 216963 19229 330662 12475 67374 14268 17242 12520 17882 270152 21825 19084 21826 19085 22329 140559 22631 19262 18749 13522 21894 12928 11308 16401 11845 19303 12927 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 22408 73016 84035 14367 192199 26564 70495 13380 16974 14362 22415 14366 22416 16973 22413 22418 14370 68588 22422 14371 22421 14368 24117 14369 57265 16010 20187 93897 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 18021 16476 12912 328572 14461 17863 17869 21823 14815 18792 20683 17395 23871 21803 16191 11909 17132 12534 13982 11459 12387 16007 19211 12843 12578 230899 21416 17134 67405 26754 14284 382056 22059 14282 13614 22051 23857 13709 12017 11770 11910 17750 13406 16153 83995 21857 12400 18619 11606 15007 12125 14609 12443 15251 13653 12576 20293 16478 18018 18019 14281 12981 16193 19252 16183 15978 14283 16477 16189 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 18712 16452 16191 20851 19247 18708 18706 14784 17096 12700 16192 12984 20850 53378 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 73341 16202 16476 19353 12912 17931 20878 29875 64099 21961 12443 12539 76142 56212 140579 18938 170736 57342 11545 26431 67268 56505 22793 56637 78757 17974 20174 75786 21335 68458 67444 225341 21417 11651 15519 20613 109711 12387 103573 54126 13367 19303 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 19246 26419 19353 11848 14158 14609 12558 227753 18803 19877 19247 640703 12005 18708 14800 16573 16973 13191 12325 18706 12387 231871 14182 12801 16480 14432 13043 13589 269060 18717 12385 17906 12388 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 15370 218772 19411 19401 20186 22260 17977 19016 21803 21926 20602 20181 20183 20182 22337 12043 22259 20787 11303 19015 19014 67544 21834 21833 19013 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 22061 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 16476 69191 328572 24068 18996 18997 12266 22433 13033 116870 12675 22200 15500 17869 11764 18002 11785 11957 17977 78330 13508 27410 23957 17978 55960 268395 18667 268527 12006 22192 66949 224903 12822 71990 667310 12521 211329 268903 11737 17979 13983 114604 100041004 67488 212391 12034 671392 67040 13982 433759 12189 16911 17128 18538 20185 12608 19109 12443 20602 11614 20850 208727 19014 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 26419 19353 16412 26413 26417 17390 14159 14360 23871 13449 26416 56458 18806 12575 20851 18479 11651 17973 19247 14786 18815 14061 14784 11601 11602 12928 231130 69257 50915 14173 12169 20416 18127 19303 21687 11607 218397 11600 14083 13709 14268 18033 21926 13712 18708 19697 18706 20850 16402 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 18021 16186 16476 26419 26413 26417 16185 15461 18750 13656 14939 21936 22163 21942 230398 12010 18761 12525 12526 15976 15975 13813 110157 15007 26395 26396 21926 13653 20849 109880 13712 320139 18754 12500 18176 12502 12503 12501 18646 640703 18751 18018 18019 14281 26420 16184 16183 15978 14103 14283 16653 16477 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 16476 26419 19353 16412 26413 19878 11848 26398 16410 330662 14360 23871 22612 73178 140580 16419 18479 17973 20662 22330 14786 11459 14784 21894 30957 12928 232906 12169 54126 19303 109905 218397 20779 14083 71302 213498 245671 110596 13196 20405 24000 12334 110157 26395 12443 18803 215449 109880 26431 17974 109711 18708 107746 26420 18706 20130 16402 12927 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 16773 16777 16779 16774 16403 16772 226519 16780 16776 16782 192897 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 17535 27354 235559 100040608 72775 69928 19367 19718 19356 69263 15574 67196 12190 235610 15270 12649 237911 330554 19355 74335 12234 101831 230484 21975 237211 71885 12144 208836 15205 104806 67561 68275 106344 103583 72151 233826 19891 211651 14088 14087 67030 11920 12189 60534 19360 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 20913 17535 21415 72433 14284 26362 73389 56436 110308 22061 22601 64058 21973 15201 12442 12831 55948 12609 12190 14694 18128 56637 11486 16400 15205 22337 18987 20997 16175 16396 50754 14776 12062 16664 226849 13395 11920 107568 56437 16009 17246 12578 67815 14104 211323 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 22352 21937 228355 12028 11820 11857 101706 670717 20740 12905 14453 57913 26401 20230 11783 12362 227753 12366 16668 12363 66593 12632 12369 20874 21418 16907 11798 13368 13347 16905 16906 21969 12043 11459 12368 14939 16885 14083 11796 21926 11545 12371 18646 12122 12367 12370 19766 11797 20787 71609 22030 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 73341 57257 109904 53972 219140 19353 319899 330662 192662 140580 223435 545156 216445 109934 16800 277360 24001 94176 110279 229877 23853 20662 13860 22324 21844 70497 11308 26934 54126 19417 19765 19418 52666 22325 228359 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 16414 11848 15235 17390 18792 17395 15162 67374 18033 17882 21926 215449 20344 21838 19877 18793 16971 18815 15894 11596 238055 16193 21894 20345 19882 14219 83964 16409 434174 18791 109905 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 18102 18720 18805 545156 18806 19353 26413 26417 11848 18793 21844 53869 11840 215445 11845 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 16476 26419 18783 26413 26417 26398 16331 12675 26401 14360 224105 17096 18806 12402 11651 19247 20662 15461 22324 13448 14784 14389 20416 19012 19303 19249 50928 215280 56743 218397 14127 14126 14125 14083 16822 15163 18778 14130 208650 16428 110157 16797 14158 26395 26396 18033 18803 20698 13609 12229 18751 18708 16150 19697 18019 14281 18706 26400 16151 19252 20963 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 20779 22339 14677 19353 26413 18596 14254 12767 26417 14687 11848 14673 14681 14678 14679 14675 14672 14674 14682 13610 14676 16452 23797 11651 18591 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 16421 14083 16412 16401 17123 11848 19303 22329 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 19353 26413 26417 11848 330662 140580 19247 20662 15461 14784 12928 14389 14388 107971 20416 327826 18049 109905 17207 218397 18205 78405 18759 100040603 94275 330914 18211 83814 18212 18053 18213 216148 17179 12064 23873 26395 20418 11350 19762 12443 19769 18803 67903 13429 56212 98878 215449 83945 20848 56470 18412 18176 18708 107746 18706 18762 21844 12929 19417 16653 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 20779 19353 16428 20393 11848 16331 16797 14360 17096 22612 15162 12143 18803 56484 30955 19157 104709 19159 14191 19158 106952 18607 17060 234779 22637 16332 11844 18176 12229 83436 101476 231821 15519 26377 18708 15461 16818 74769 18706 19211 11840 11845 109905 16653 20963 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 20185 22601 26413 19116 26417 19109 14360 68652 16452 20851 100042150 16206 18708 13874 18183 74769 80707 15200 18706 14812 14784 11491 16396 13869 13866 12223 20850 13385 12398 83961 17999 107568 20416 17246 211323 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 18747 26413 26417 16331 110157 17096 12700 26395 12984 26396 20846 20848 22631 18712 18749 16452 20851 20293 18176 19247 20662 18708 15461 16150 14281 18706 12981 14784 14389 20850 12982 20416 15900 18413 16653 20963 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 26399 26397 13631 29857 16765 12443 320795 20648 65964 26415 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 19294 69697 210126 17309 13636 211446 17920 13645 11828 13836 11830 216963 233765 65970 17356 20909 22323 13649 16582 11848 15234 17295 22793 19877 17973 109711 76884 22330 12387 20336 12550 50884 16001 11308 16000 18717 12385 13367 11845 17906 12388 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 18747 16416 17164 26413 26417 19229 15170 11848 15239 19271 16410 15516 14159 22370 27371 14360 224105 11640 226101 19255 207565 12562 26416 12389 12402 11651 17973 15519 19247 103583 22330 14783 12387 14784 18750 14388 11840 18127 12385 19303 13430 26397 20779 22339 14083 14254 16542 110157 29875 18753 26395 26396 18803 109880 18607 17974 19877 640703 18751 18708 26399 18706 230126 19094 17999 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 18148 15361 328572 12028 12567 116870 13684 17869 17395 100683 21877 69719 20425 67154 12530 13681 11757 109115 216185 18712 20713 108143 66464 15510 14732 100088 100043349 12914 208643 72504 15519 12151 56426 21429 67025 59026 380669 12444 21752 16828 13557 67014 72195 64602 66942 22042 75597 18642 13806 15902 13665 17187 67065 68632 14534 12035 18103 18102 18263 17127 56456 17128 15525 27354 170676 22059 20525 56505 20174 20613 81601 11799 14283 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 26397 20779 18481 22034 19353 26404 216527 64143 19091 70686 26406 26398 14360 224105 17096 22612 15162 12143 26416 14191 18218 63953 18479 16818 26399 19252 19766 66513 19094 56044 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 12703 26419 26417 15170 17342 17096 56484 12914 12402 17311 11651 19247 20662 15461 22324 12043 14783 13448 14784 19211 14388 20416 16590 26411 21682 20583 110157 16923 240752 14158 17444 114715 17179 114716 56792 26395 23921 26396 13857 12015 19277 20846 13856 20848 16452 18607 56637 18708 18706 20850 12929 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 26420 20423 26419 19206 12159 18550 14178 14734 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 20750 20779 22339 19353 16412 14268 14205 11490 22329 22341 11489 20229 16516 74145 21923 21817 11495 11501 18126 212503 12981 104099 12982 19303 12927 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 19090 227525 319583 59047 21673 54125 72103 75570 66408 56626 108138 22596 14375 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 271457 16476 26419 19353 26413 26417 11848 26398 16331 13685 15239 19271 13684 26401 224105 23871 56717 19255 73178 18479 12402 20404 11651 17973 19247 14064 20662 15461 56513 12387 14784 12928 14389 12550 14388 20416 12385 11845 19303 109905 20779 14083 19246 11789 18759 110157 15234 17295 26395 26396 12015 18803 13653 215449 18607 17974 56716 16332 11652 20613 18708 107746 18706 18762 18222 97998 16211 70584 224116 58194 226970 74030 12929 74370 13858 67605 74334 12927 56705 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 218397 20779 14083 14677 19246 13645 26413 26417 15170 13649 14679 227753 73178 20846 18803 20848 17974 18176 18479 17973 19247 20662 18708 15461 74769 18706 14784 21894 14388 18717 20416 16653 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 22068 14702 14062 320129 14677 18797 67804 16801 56440 14688 18795 19878 75547 22323 109689 14687 11848 14673 14681 14678 18796 18753 14679 192662 14675 13429 14672 14674 14682 14676 22793 19877 320795 14064 18751 18708 18706 14061 18750 18127 17906 18752 13430 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 14083 19353 16412 12767 14177 11848 21788 20971 20315 66911 18753 20304 17395 14268 17242 16774 57916 67903 21825 16772 11489 53378 21923 109711 18815 14061 14182 18750 14173 14369 16402 13430 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 26419 18519 328572 27374 12566 18002 110854 216080 65019 23988 53892 225055 67956 13163 26416 100043295 26374 17248 219022 13560 110750 67773 226830 50883 69181 73251 19052 333654 12450 12914 11651 67025 59026 11920 12578 15258 22059 93687 27401 214897 21849 252870 18753 70425 103236 27373 11350 104318 12649 56637 22632 26420 12428 68098 81601 17246 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 18761 19225 18021 19246 16476 208650 14462 12567 19016 16364 21926 13653 13654 16191 57765 17254 19272 12477 13655 66889 12367 22778 640703 13139 17132 20371 18018 18019 14281 12981 16396 16184 16183 15978 13555 14103 21947 13656 381319 18986 14283 16477 16189 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 12387 16480 12550 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 13712 14676 16367 14677 16476 26419 19353 18479 26413 26417 14687 11848 14673 14681 14678 14281 14679 12562 14675 26416 14739 14672 14674 14682 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 14702 20779 14083 14677 18797 19353 12912 14688 26413 18795 26417 14687 110157 14681 14678 18796 14679 26395 26396 18803 234779 11835 11651 18708 15461 20415 14714 14281 18706 75273 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 50883 22059 12795 12532 12447 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 18021 14284 16476 328572 23857 83995 17390 18792 14609 20683 17395 12443 16774 20293 16478 18793 18018 18019 12428 17313 15368 16193 13179 353170 16878 21824 22282 11911 12843 18127 14283 12578 16477 192897 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 21750 17535 27354 13016 21849 54401 19367 225182 19356 11350 26374 12530 15270 12532 50883 21975 12144 227525 12122 108138 81601 211651 13006 11920 20184 70681 12189 17246 24061 93765 27223 240087 19360 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 22029 21937 53859 11796 67384 26419 12675 670717 12905 11783 12366 18033 18035 13163 21926 12369 14082 12371 14102 12503 12122 12367 26408 19697 12043 26400 12370 19766 14103 12368 12633 71609 22030 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 20387 117149 20201 13003 17087 106759 12111 16179 108960 21899 21898 11848 142980 20209 12675 20202 24088 21897 266632 17874 12475 15510 16150 16151 434174 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 16451 14462 16173 16171 50931 20847 16162 16159 21803 20846 246779 21926 50498 20849 20848 16452 16176 57765 54721 16161 16160 16193 16183 15978 20850 16195 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 26419 19353 11820 11848 12675 670717 11783 192662 66593 11798 18749 11651 18815 13555 12368 20416 18049 11796 22059 22034 18205 78405 16179 18759 94275 17393 18211 18053 12125 17874 12064 12015 18550 17984 17136 68585 18412 20661 72843 22627 192656 12070 75625 18377 170936 19716 20598 66647 12371 11852 11853 235402 17392 12367 18708 16150 26420 18706 18762 11491 16151 11797 26414 19164 100042305 59287 208117 100039623 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 56637 14367 606496 214897 11789 16974 84095 12005 72293 18719 13542 22416 240756 13544 13543 26554 12387 71810 226849 12389 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 20750 20779 16476 26413 12393 26417 24064 19229 15529 18792 17395 14170 12558 20846 18803 64654 12322 14186 18607 14184 20851 12402 11651 19247 20662 18708 18793 14281 18706 20111 14784 14182 231637 14164 70584 83379 12550 13043 171463 17967 14183 14388 20416 327826 12388 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 17125 17128 21909 17129 11705 55994 11477 110542 12162 14225 12168 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 76804 84704 114774 215114 18813 57257 225115 15382 50523 57908 75502 56406 104263 19229 627557 12445 14228 22200 22215 18095 21413 232286 18477 56218 227753 328365 17152 72993 17978 21815 268903 11835 11651 12571 20807 75273 12387 22596 14375 12189 59004 12578 19090 229615 12443 59035 99982 50528 12370 56469 22196 19014 227292 110651 56705 14200 21804 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 18720 22793 20779 19353 11651 11652 13649 22323 11848 18708 18706 12387 14360 16480 12550 16475 12374 18803 12385 12388 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 16194 16476 16451 12608 19353 12048 26398 21857 17869 17342 18753 229615 12609 15162 20846 12944 26416 16803 17210 20848 22027 56458 99571 19267 12702 21943 232345 16452 16362 11651 54721 19247 20662 18708 22324 14281 26399 18706 14784 16193 14389 19094 56469 14388 16477 16911 16195 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 13838 13837 13836 13842 13840 13841 13839 13640 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 27354 235559 18817 19361 12566 54401 269582 19367 19718 19356 69263 15574 12190 235610 12530 12649 12532 22631 19355 12234 17220 72930 214552 19052 17216 51792 23834 66131 54380 21853 68275 106344 103583 72151 19891 12428 211651 17246 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 12234 56637 93687 14367 606496 21402 11789 16974 26965 12005 13542 22416 13544 13543 12387 27373 104318 12006 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 16367 14083 19246 110157 18753 12015 14694 22627 22631 18607 17974 11651 18760 19247 20662 18708 15461 14783 18706 14784 18762 12928 16001 16000 384783 20416 12929 19303 12927 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 26397 16176 26413 26417 640703 71914 26398 195046 69538 26399 26400 16173 12362 26395 26396 21926 18667 22329 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 19682 245650 243923 77974 14688 14697 107477 14913 212541 24013 20215 19892 225600 19739 18587 79235 14699 214111 14685 14919 12788 18588 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 15379 193740 18021 14451 27401 328572 18817 12442 12567 12566 17869 17390 20683 26395 12443 12190 12531 50883 606496 19645 12914 104156 12534 14281 12428 13982 11799 18005 54124 108000 12615 14235 12616 12578 22594 16775 20877 12447 21802 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 14702 110355 227288 271457 18797 14688 18795 109689 14678 18796 17096 15162 14675 13429 30955 104709 14191 14676 18805 18607 18754 12402 216869 11651 18751 18750 18752 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 16456 21810 78369 16411 15896 14131 100689 110135 16414 14161 14723 12266 14058 19123 18792 385643 99571 22329 21838 18793 15894 381924 16007 16408 83964 16409 21947 18791 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 20913 20528 19047 20909 16334 18759 106628 240028 50518 55948 22318 54401 104215 14936 16337 140491 100039786 22628 22627 22631 22629 210789 56637 11651 11652 640703 18762 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 271457 16476 18783 17869 14360 22612 23988 73178 30955 104709 20851 12402 13860 16818 16971 232906 18591 13430 18596 17356 94212 110157 29875 26395 26396 11350 20846 215449 20848 20698 13609 16452 17974 18708 76884 107746 74769 18706 26400 242687 20850 13043 50884 26414 11308 110651 12927 19106 16706 26419 19353 16416 26413 26417 68089 67771 11848 26398 11867 56378 19271 16410 66713 74117 17096 19255 192662 15162 108100 12143 101314 76709 14191 72930 19052 51792 18479 17973 19247 20662 15461 20807 14783 13448 14784 12928 18750 19211 14388 20416 109905 218397 20779 19246 12988 55948 54401 18753 20491 65962 21345 20469 26941 18803 69710 98910 19341 214384 100039786 238130 22628 60595 22627 109880 22631 13712 22629 18754 18176 16478 14281 26420 16653 22325 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 11477 14225 11482 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 19294 20779 14083 16456 227377 19353 16416 18596 17356 29875 16410 215449 19274 12737 58998 58235 18708 107746 18706 12387 21894 12928 12550 18717 12385 109905 18591 22325 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 16476 26419 19353 26413 26417 15170 16331 12675 26401 23871 17096 26416 100039026 11651 20662 15461 13448 14784 19211 26409 20416 218397 12988 22034 14130 94212 26411 110157 19055 26395 18033 18035 13712 18607 17060 234779 24056 12047 19057 240354 12229 108837 108723 19264 26377 18036 12517 640703 12518 18708 16150 12478 19697 18018 15985 12483 14281 12325 18987 19056 18706 12042 16151 22325 20963 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 223254 102098 207212 57257 109904 53972 16801 213498 110596 75547 11857 11848 11855 192662 69710 223435 13605 12576 106952 216445 109934 16800 110279 23853 22324 17925 72754 69632 171207 232906 11856 213522 14570 442801 117600 71704 94190 50768 52666 234094 22325 56349 73167 17207 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 22318 11435 22249 20910 20614 20979 20907 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 328572 54485 53870 14462 18129 18131 18132 13388 13728 17869 50530 56309 16449 225164 11487 14357 17150 13389 18011 227325 16450 13386 12805 16924 12234 12575 12402 21402 26965 433759 53869 13806 20185 27401 19208 13016 225182 12443 18550 13429 103806 20602 56381 11489 18128 22632 99982 19664 270118 18222 16396 50754 100042305 13858 59287 208117 16189 100039623 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 17242 71951 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 16186 16451 16453 12048 13709 16992 12445 17869 20683 20851 18646 19247 16185 12571 20662 18708 20371 12043 16818 12428 12444 18706 14784 16184 16183 14389 20850 14103 20416 16189 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 18747 20779 11435 16476 26419 19353 26413 26417 110157 56717 26395 26396 12015 20848 84092 18016 67588 16452 13867 11448 73181 67299 18176 11651 100042150 19247 20662 18708 15461 74769 14281 19056 26420 18706 14784 13866 26414 20416 16653 211323 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 14702 271457 18797 14688 18795 22323 109689 14678 18796 17096 15162 14675 140580 13429 30955 104709 14191 14676 18607 18806 19052 51792 19354 12402 12765 216869 19349 94176 11651 18751 18750 53869 18752 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 15376 15375 15377 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 20969 20970 15529 20971 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 20750 22339 16456 21810 20969 16416 110135 18596 14161 94216 226519 12830 16542 20971 16410 22370 16777 18792 21813 12829 14268 12828 12826 21825 12842 99571 20698 21838 21923 15891 14118 18793 16728 18613 13612 16423 16007 434174 16399 12843 18591 16775 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 14061 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 12703 16186 16476 16451 26419 16453 17164 26413 26417 19229 11848 12566 17869 14360 13449 26416 20851 19247 16185 20662 15461 12043 16818 56324 14784 22780 20844 14389 216233 384783 20416 218397 16367 110157 12700 26395 26396 20846 20848 12702 18754 18176 18751 18708 14281 26420 18706 16184 16183 15978 19094 20850 16653 20963 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 14733 14734 71951 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 217166 21853 20893 27373 18143 53610 11865 12953 12952 12753 140858 12649 18626 18627 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 12703 16186 56717 26416 19349 11909 20852 16185 16818 14939 12010 26397 20303 12525 14938 12526 16177 17873 18034 13813 15284 23882 12774 19698 15007 16173 18033 16162 16159 20846 20849 20848 192656 16452 16182 14969 14968 16176 57765 12500 12502 18126 16174 12503 12501 54721 19697 16161 16160 14281 26399 16184 12504 16183 15978 20850 14103 56632 16189 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 16420 16421 20969 21812 17123 14118 18793 16410 13612 22370 18792 16007 14268 320910 16401 16419 22329 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 20750 16202 57257 19353 16416 26413 26417 19229 11848 16410 22370 21813 12402 11651 15519 19247 22330 13612 21894 16001 14173 16000 12843 19303 16367 12977 20779 22339 16456 14083 12978 20969 12833 12832 12815 30924 12814 18704 12831 78560 94216 17304 12830 16542 224020 107650 12829 14268 12828 12826 12825 12824 12842 12576 12836 12835 19877 12834 18708 18706 12370 12927 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 22059 18519 328572 12028 22151 60525 64384 22143 17261 50709 93759 15395 68738 64383 56484 56458 209011 12575 19017 12914 17927 208727 14375 14200 54601 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 18747 218772 19411 19401 26419 18519 328572 26413 26417 17977 66671 19659 17978 26416 17420 12572 20602 15183 268903 20181 20183 17979 12914 20182 11651 22337 12534 433759 18750 18752 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 26754 11863 22059 15519 67923 112407 112406 22346 15251 71745 12578 53417 319594 56292 14694 216440 56438 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 20387 20423 16476 12608 328572 16334 22433 18095 11764 22370 11957 20683 78330 13508 20703 12576 12822 11819 320951 667310 14526 20390 22287 268903 18029 11835 72082 17979 12914 18027 15376 114604 15375 100041004 15377 14281 13982 238055 18986 12189 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 26419 93687 19353 11848 18099 22612 19016 12322 68652 19877 14367 26564 216869 208846 192176 84505 320790 13542 18019 13544 13543 26420 22418 18762 68588 66513 26414 14368 26409 14369 57265 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 14702 20779 14677 18797 14688 18795 19878 14687 11848 14681 14678 17390 18796 14679 17395 14675 14672 14674 14682 14676 18176 13983 11651 20662 18708 15461 268980 14680 15200 18706 75273 13982 14784 19094 16001 16000 20416 18127 17698 16653 12927 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 16319 18741 21415 12590 67772 16543 16476 73389 14175 67087 99377 72693 328572 81004 18014 64406 73739 80334 12592 59024 17869 17390 17342 21413 17395 100683 17978 12006 12234 11835 21402 13380 26965 12444 21752 12387 15182 433759 16007 12550 15902 12578 16842 21416 13003 11789 13016 20583 55948 54401 12443 12326 100039786 22628 22627 22631 22629 20174 21885 13544 12291 17709 20997 21414 140486 21886 20586 234130 21372 103573 11513 665113 16600 21888 17877 14797 16678 17928 77578 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 26419 12048 15170 21682 16331 16923 17096 18033 13857 20846 18803 26416 13856 12702 16452 234779 20851 12402 12229 19247 20662 18708 15461 12043 107746 14784 20850 14388 384783 20416 12929 109905 22325 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 26397 17873 22034 19353 23882 216527 26406 269881 53608 26401 22166 330177 216965 26407 26416 68652 26408 640703 12323 26399 66513 19094 13197 11920 26409 22030 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 56456 73389 27401 22642 17869 224105 23988 18854 100683 109115 216185 56505 108143 56637 66464 20174 19052 12005 81601 50754 72195 226849 12578 17187 14534 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 13609 19225 22339 14677 19353 26413 18596 26417 14687 11848 16542 14681 14678 18796 14679 17250 18803 18591 20698 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 17126 20779 22339 14254 11820 14360 17096 22612 21813 20563 15162 11905 19122 12143 21803 620395 16772 14191 21809 21812 16818 14182 14733 14173 211323 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 22068 16476 18797 26419 19353 18783 26413 18795 26417 19229 11848 18796 18755 26416 70086 224129 11512 11514 11515 13617 13616 13615 104110 13618 58861 432530 210044 105243 104111 11651 15461 20544 12928 18750 12843 18761 20779 14677 13614 14687 14673 83995 110157 14681 14678 18753 14679 26395 26396 14675 12825 14672 14682 14676 16452 18754 18751 14680 14281 11513 12927 18752 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 22339 22340 18654 14254 18187 18186 14257 14205 16542 22341 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 22068 16476 26419 19353 18759 26398 14360 73178 12015 18803 17974 216869 11651 17973 14064 21872 18708 12488 170643 74769 54631 26420 56513 170484 18706 14784 18762 26414 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 14702 16476 18797 19353 16801 14688 19229 11848 17390 17395 17096 224129 11512 14674 11514 11515 104110 18806 432530 210044 104111 11651 18760 15461 65086 14745 78134 53978 12928 11548 14388 19303 20779 14083 14677 22051 13649 14687 14673 14681 14678 18753 14679 65962 18033 14675 18035 18803 14672 14682 14676 56637 18754 12367 18708 19697 74769 14281 15200 21844 11513 12927 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 20750 109700 16398 241226 213119 16412 226519 16410 22370 18792 12475 67374 17242 12520 21825 21826 99571 22329 140559 12822 14118 18793 114249 121021 18073 12843 16775 22339 21810 12833 12832 110135 14161 12815 12814 12831 94216 12830 16780 16782 16773 16777 16779 12829 14268 12828 12826 16774 12825 12824 16772 12842 16776 12836 74145 12835 21923 21817 12834 16400 104099 16401 16403 16402 16404 319480 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 18787 14294 14289 20779 14293 76701 19353 16416 16412 110135 18596 16414 14161 50701 13649 16410 22370 15234 330662 18792 17395 14268 21803 99571 16419 16400 17392 18793 16971 18815 12928 16409 56640 14756 13035 16402 22359 17381 12927 17386 71785 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 12912 16412 328572 17869 110854 20683 19650 56484 20375 12579 12575 15183 13380 12043 22418 433759 12843 12189 15902 17187 17126 17127 17128 14581 21374 94280 15360 12192 22642 18596 18044 18045 18046 12759 13435 22084 18173 66271 14319 23894 20304 12609 29811 12606 17988 229663 21873 20377 12443 56752 17122 56363 12576 21673 16852 13866 13198 13197 12633 16403 15900 192897 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 13867 13645 15519 100042150 13649 13874 18183 15200 13869 13866 12223 83961 11839 211323 21802 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 14702 110355 14688 14461 56233 15185 15184 22151 54401 14815 22143 12053 232232 12326 17260 20602 68558 170787 19727 71458 22627 79221 15183 15519 20807 14460 13982 103573 208727 22196 19384 19386 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 229317 22601 17131 75788 18854 21813 21803 13163 12389 11798 19045 68652 19052 216869 21809 21812 20662 56513 12387 14784 66513 14219 26409 20416 17126 17127 17128 83814 12322 22627 66313 21814 17872 18607 73122 240025 20742 68010 71978 218441 67068 93836 19053 20901 12005 230597 13132 16396 107568 14225 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 16421 16407 12550 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 16822 16476 26419 18751 26398 26411 16797 13169 26401 17444 12928 26409 12929 26410 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 18747 15370 18021 54720 26419 12048 328572 12028 26417 26401 18755 26416 100039026 18712 12914 12043 18750 18761 93687 55948 54401 18753 17261 12015 12326 100039786 22628 26410 22627 22631 22629 56637 18754 12367 640703 18751 56398 18018 18019 100039592 26420 227720 104248 14232 18762 16211 53901 103573 19384 238276 14225 18752 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 53859 15170 16331 12675 14360 12402 11651 17973 19247 20662 15461 22324 16818 14784 14389 18750 19211 20416 109905 18761 64177 16822 12988 22034 16428 94212 26411 16797 17444 18803 26410 18607 14969 14968 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 192176 18751 12487 16150 19395 12519 13169 12524 12042 54354 16151 22376 12504 109305 24055 53416 20866 23880 19419 77799 16653 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 18747 218397 22339 26413 14254 26417 216148 18803 15251 12389 18607 12402 22340 18654 11651 17973 15519 18187 19247 18186 640703 18751 18708 12488 18706 18750 18127 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 14784 56717 13645 13614 20416 13649 20662 15461 13617 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 18747 319757 14632 14702 14634 67661 14677 20423 19335 100041953 93687 214897 14633 14688 19206 19646 20466 14687 14681 14678 18753 14679 70425 26395 103236 27373 245688 104318 12234 56637 60406 12914 216869 16854 15376 11651 20467 103583 15182 433759 56469 103573 211401 269209 24069 20747 16568 21821 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 218397 16367 105504 19246 211446 20411 16334 20393 18759 106628 16331 13685 104215 16337 23921 56484 12389 19262 18607 17974 12402 11651 17973 11652 19247 14064 53413 20662 18708 15461 107746 14783 56513 18706 13448 14784 18762 20336 12928 69940 50915 107371 20416 66482 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 18590 54635 18595 18596 18591 71785 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 20779 14083 13636 57257 16332 19353 13836 11431 12402 18479 11848 18708 18706 14784 21844 232906 20416 22325 12927 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 100040260 23980 271457 16476 12048 12912 19060 11843 23938 56419 17907 23939 26405 19730 22695 67603 56613 73086 56717 73178 17260 11909 11651 667739 13860 56044 13645 13649 110157 29875 26395 26396 20846 20848 78757 56716 227743 18708 76884 74769 18706 242687 50884 11308 110651 16706 26419 19353 26413 26417 68089 67771 26398 11867 56378 66713 74117 26401 27371 108100 101314 76709 17125 18805 18806 19052 51792 14064 20662 15461 20807 20544 14784 18750 14388 20779 12334 55948 54401 18753 12015 98910 13653 100039786 22628 22627 109880 22631 13712 22629 18607 71978 18176 640703 14281 26420 225870 18762 19252 16653 22325 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 19353 21770 11848 100040603 29875 27226 18472 13424 56430 23924 12570 11350 18476 17755 13131 13193 83431 18475 19699 12569 100039026 22627 640703 18221 12568 16976 22359 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 107503 109700 19352 19245 20779 19877 12575 19353 16412 26413 11853 26417 11848 12566 12428 11606 22143 13653 19244 12927 12447 56187 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 20779 26419 19353 16416 26398 14360 17096 22612 15162 13844 270190 12143 13429 13642 13641 14191 50780 17974 13846 18708 16818 18706 21844 16399 26409 19249 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 109700 16398 12912 16412 26413 26417 26398 14268 26416 14205 12842 22341 11651 20662 14257 18708 18706 20111 14784 12928 19094 12843 20416 16401 16402 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 20779 13636 13645 13836 16416 216963 109689 13649 15234 17295 14675 14672 14682 19159 19158 14676 78618 16554 320495 16867 216869 216859 50753 212285 231821 17973 70676 232227 11555 16399 22095 11845 19303 11607 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 16451 22061 22601 328572 12028 12795 18817 12566 17869 16190 20683 93759 12366 23988 18854 26416 56484 16450 12235 18749 11486 12575 12571 22062 12237 319618 12534 30948 16180 226646 229933 21945 15499 22431 22142 14252 11576 18196 12018 207742 23886 19012 63958 68048 18611 12448 268882 18787 14651 223752 56612 19361 18211 55948 83814 12125 11350 12190 12649 14694 20703 15214 19645 14102 19697 14460 80707 12428 68098 81601 16396 19094 17246 14104 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 26397 14702 20779 20292 14677 56066 56744 12766 55985 14688 26413 15945 26417 109689 14687 110157 14681 14678 14679 56717 26395 26396 26416 13429 18607 78757 56716 18176 227743 11651 17329 18708 15461 74769 26399 18706 19094 16653 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 18747 12608 12048 16188 27058 194231 16331 12700 12984 22628 22631 18712 18749 16452 15901 20851 19247 18708 18706 14784 433759 14389 20850 20416 18413 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 18747 110355 14702 320129 19353 16801 14688 11848 14360 18796 22612 17096 15162 12143 18755 26416 14674 30955 22329 14191 104709 216869 11651 14697 170735 16818 15894 18750 53869 18127 18761 20779 13645 19091 13649 19222 21390 14673 19214 14678 18753 14675 26941 13429 14672 14682 14676 19877 21817 18754 20339 18751 18762 19094 20963 18752 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 13645 19353 16412 13649 226519 15235 16780 18858 16782 55948 12821 16773 54401 12527 16777 16779 17295 16774 12369 16772 100039786 22628 16776 22627 22631 22629 13867 20181 20183 20182 11651 18708 15461 18706 16175 14784 19882 13866 12550 18750 20416 16403 16775 192897 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 13631 26413 26417 13685 12566 670717 13684 56430 56717 18854 13681 12234 18805 18806 11651 103583 15461 18750 12447 16367 20393 22084 110157 55948 54401 12421 64930 75705 26395 13629 26396 22241 54170 18569 109270 73826 52187 29869 100039786 68441 22628 51897 22627 109880 74747 22631 100042570 22629 106298 18607 245670 78757 56716 22632 19017 18176 227743 16150 20111 97998 20787 74370 67605 16653 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 12234 53859 18034 18033 19698 12675 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 16476 12048 13836 64058 328572 57913 11783 20683 12362 12053 26374 110750 12575 12450 12914 13380 15375 22062 22337 12043 21781 15182 13555 16878 12368 11576 12018 23886 14534 18787 13003 13649 11910 74747 26921 20312 19079 21933 242705 19645 71887 15469 14102 107986 12177 12122 27056 29813 14149 66824 57748 21981 68428 13207 14000 20586 71361 235281 268973 14775 13496 382985 15194 67941 17246 12607 209456 218215 22178 20750 17685 66813 59092 17350 60599 12050 22061 319801 140742 12028 12227 12795 18996 12142 18997 18861 15248 20400 13033 66214 94223 69076 17390 12454 21354 18854 100683 17210 12389 12822 13615 108143 12521 13557 19211 21802 193740 18538 22059 18044 11789 18045 18046 20583 22084 55948 15234 17988 17295 20724 59035 12047 68098 19252 240672 12062 13197 16009 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 18747 104110 18754 432530 210044 104111 12912 14680 78134 73086 11513 224129 11512 11514 11515 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 18102 20779 271457 19246 13645 19353 56440 15170 13649 15239 14673 29875 17393 18212 19876 14360 16002 12064 12558 104836 17295 11487 109620 17288 11350 63955 20562 56805 14674 12914 19349 17392 12367 15461 14573 12387 21844 16480 12550 19713 16001 74030 12385 11845 12388 14585 13430 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 18747 218397 22059 216963 21770 20878 72119 18035 16475 83431 218977 100121 12531 66077 18245 12877 56371 56637 75786 21335 18479 11651 11799 13197 19384 12615 54126 12189 17246 320165 20877 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 22029 53859 11796 16476 26419 16453 22034 12048 208650 26398 17869 26401 18033 18035 26416 30955 104709 22031 64435 56196 21939 21929 11651 18708 19697 74769 26420 18706 19094 20850 11797 26414 21947 22030 16189 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 71990 236193 20587 17979 13983 12266 57376 22200 18002 17977 20586 23957 17978 22192 11614 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 20878 20877 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 18747 17128 22059 12912 13033 22084 13728 55948 17869 54401 64930 56717 12539 100039786 22628 22627 22631 22629 56637 56716 12283 75770 20869 19165 15519 70661 232944 22350 71728 381979 70415 66993 17691 13982 72149 235344 74343 18612 227154 74370 67605 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 13846 13845 13844 270190 13642 13641 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 26397 18205 12912 17164 26413 23938 26417 23939 26405 110157 18753 73086 193034 26395 19762 19769 26416 98878 13653 215449 17260 12569 109880 13712 18176 15461 20807 14281 26399 20111 12568 109905 16653 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 26397 22029 21937 11796 67384 228355 18201 26406 18759 12675 26401 22166 18033 20846 21926 12389 18412 14694 68652 26921 21929 14082 20598 26408 20597 16150 19697 26400 18762 12370 11491 16151 19766 66513 11797 21938 26412 665113 27206 26409 74256 399510 225028 71609 67338 22030 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 12895 18770 11364 22228 22139 11370 18609 12608 12894 12912 15107 71911 234724 230163 16334 18534 20526 20927 16514 14377 21869 16006 14815 12609 15227 20683 12606 21405 11655 103988 11657 13386 15378 15376 11651 15375 18015 15377 14061 11576 22042 78070 11806 100040592 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 16476 26419 19353 26413 26417 68089 56419 67771 26398 26403 11867 56378 66713 74117 26401 224105 22612 56717 73178 192662 108100 26416 76709 404710 18805 18479 12402 11909 14064 53413 13860 15461 56513 12387 12631 12550 12385 54126 17906 16885 16886 26397 20779 73341 11789 110157 29875 15208 51789 18000 226751 18508 109880 56637 18754 18708 26420 26399 13383 18706 26400 18762 21844 70584 19417 22325 12927 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 110355 14702 18797 19353 14688 18795 19229 15170 11848 16331 15239 20315 14360 18796 17395 22612 17096 56717 15162 12143 56458 14674 30955 14191 104709 20851 18479 216869 11651 19247 170735 22324 16818 12928 12631 19303 16885 20779 14083 14677 12988 64143 12767 94212 14687 14681 14678 14679 20847 12015 20846 13429 215449 20848 26385 20479 14694 50778 116733 56085 16452 18607 14969 78757 14968 56716 12500 12502 11852 11853 12503 227743 19264 12501 18708 74769 18706 18762 16396 231637 12504 20850 12927 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 22629 16985 102626 14009 17164 12912 15507 20807 110157 22084 55948 21823 54401 19094 21423 26416 12531 100039786 22628 22627 22631 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 16476 93687 26413 21770 11789 26417 13016 18099 13388 17869 21405 11487 22408 14357 12443 100039026 12234 18128 56637 73016 56811 93960 14296 21885 12914 13380 16974 14362 12005 103583 13542 19664 14281 12387 433759 66513 19164 24117 26409 17999 100042305 19015 14797 59287 208117 100039623 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 20423 73389 22061 64058 328572 12028 18817 17304 12675 18753 16449 20683 18854 11350 63955 100039786 13654 12234 20724 11486 12575 16400 192119 22032 14102 20833 18294 21420 73472 20148 16150 14149 14027 22337 18104 66993 229933 16396 14776 14252 13197 107568 23886 17246 16009 12578 68048 192897 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 12703 16451 15979 12608 328572 26413 17131 26417 26403 69635 26401 18753 12362 19255 56717 26395 108058 20846 215449 12322 20848 16452 16176 12402 12914 16362 11651 19247 640703 18708 107746 12323 96979 12325 16391 18706 15978 56469 12929 59004 109905 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 19158 18720 18806 19353 12847 13196 12757 260302 56041 107338 12504 228998 76932 11771 11773 56494 68137 11840 74325 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 225471 73914 16177 16476 26419 22034 16179 26406 18759 12675 266632 12362 17874 18033 18412 68652 16176 18708 16150 19697 16180 26399 18706 16175 18762 16151 66513 26409 16181 54473 93765 111173 16178 66589 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 18747 15370 16667 22088 74551 16476 18514 26419 110308 12640 14229 12912 19060 68094 328572 26413 12028 83797 12355 26417 22354 14462 225888 100043429 14228 18736 14815 17977 17978 26416 20375 99571 12569 18749 16191 12575 20851 12914 11651 15519 15894 15182 433759 11576 12991 21374 22059 20393 83995 19109 55948 18033 20846 13653 20588 22629 56637 57765 16362 20339 16163 19697 18018 14281 26420 12981 16193 16183 20586 15978 19094 20850 18976 26414 16664 12568 18986 17246 16189 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 20779 22088 271457 14083 13645 208650 24064 13649 15239 110157 100041766 218038 13854 70527 216080 231125 66700 104015 13429 84092 16443 18176 12402 20404 16206 20662 18708 15461 74769 18706 14784 66105 58194 20416 54126 13858 16653 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 73389 18519 328572 27374 15248 12445 12566 17869 18792 11783 20683 93759 17215 18968 100683 104158 19650 21877 234677 20859 12369 17865 22294 83767 17210 12530 20135 20133 22171 12580 13909 19385 56353 67935 52679 50496 12575 23834 436059 13361 12914 67155 211586 18392 22062 12534 21781 13557 433759 13559 13555 104394 11920 12189 12578 22594 12447 12448 14534 18787 235559 209446 19646 19651 21849 12606 225182 12576 22632 242705 19645 12428 12419 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 21937 12234 21929 240354 22034 257632 16150 19697 12675 12042 66105 16151 18033 18750 11797 18035 103573 21926 74256 11920 19384 111173 192656 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 14360 13839 13640 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 53859 15170 12675 14360 12402 11651 20662 15461 22324 16818 14784 18750 20416 109905 12010 18761 12525 64177 12526 16822 12988 22034 94212 16797 17444 15007 18803 26410 18607 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 18646 18751 12487 16150 19395 12519 12524 12042 54354 16151 109305 20866 19419 16653 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 16476 20687 26413 20466 26417 22215 17869 20683 56717 245688 21803 229512 60406 17119 11651 15519 22427 208084 20467 28113 245474 101185 21749 497652 13982 21752 103677 21951 15182 22596 22431 15381 433759 98999 13555 11546 57321 72400 100043508 11920 14375 17187 19360 21750 17535 17127 15976 100041953 27354 13645 19646 13649 19367 18033 11350 12443 15574 22627 12576 19355 11819 12144 16362 14281 16183 15978 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 16476 328572 12567 12445 12566 17342 93759 19016 26416 17260 20375 14836 19052 20587 12575 15183 12914 11909 17927 12418 12571 21429 21781 12444 13557 433759 13555 104394 270627 18505 14312 12578 19660 20937 12447 13433 12715 56321 223922 21374 12608 27401 19646 13709 12393 13016 110157 12609 12606 17295 11350 12443 12576 21808 20390 242705 19645 26420 12428 12981 20586 19094 17246 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 17126 73122 17127 218210 17128 19042 69274 26413 26417 640703 100039592 227720 26401 16211 22196 227292 59004 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 18148 16476 12912 328572 16414 14461 56233 20315 20683 23871 17977 17978 17210 15378 21786 13805 12914 11651 21752 16828 15368 22042 13806 15902 18787 26754 17127 22339 17128 15277 13614 15275 79362 11520 12767 14151 230099 18671 16846 18655 19883 112407 11535 12870 20525 23959 26357 16006 72157 18746 18641 17988 11674 103988 170768 20893 17684 22041 18550 13856 15251 100042570 11863 18126 14281 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 26419 16412 26403 18472 14360 14811 19099 17755 13131 19699 12569 56637 17974 16800 16400 12402 11651 18708 107746 18706 26400 14812 12568 16976 12929 22359 109905 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 21933 14082 26419 26413 26417 26398 18708 20597 16150 12675 74769 18706 26401 12370 16151 19766 65111 12633 22035 71609 22030 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 26420 14702 19094 26419 14688 26416 12918 14680 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 109700 12977 20779 22339 19246 16451 12978 16453 13645 229317 16412 18596 13649 16334 16542 15234 16337 19255 17295 20846 70361 19341 20848 20851 12914 20852 20662 18708 74769 100039592 18706 14784 16211 20850 56469 14388 20416 18591 19106 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 17128 19042 69274 26413 17131 75788 17129 12159 55994 66042 17130 11798 18121 12168 66313 11625 12156 17125 68652 17872 69585 19045 12161 56637 12166 12667 68010 68799 12622 218441 244058 23892 14313 20481 227720 66513 26409 12162 227292 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 14676 14702 19877 14688 19878 14065 14064 11848 14061 18796 14675 14672 14674 17906 14682 FSH%NETPATH%FSH FSH 26396 12640 11652 14308 14309 72993 14772 26385 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog 22627 19207 117606 70208 59024 69792 264064 100041953 12387 110355 13548 14451 269209 14632 14633 16147 216869 13363 24069 19014 75050 18747 19206 15245 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor 433759 15507 11651 14083 11835 18708 12912 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor 19085 13163 19087 75901 75788 76630 19303 72183 12443 15529 18744 57258 17222 20481 56440 54601 67804 20682 20692 16478 20742 12189 21417 21781 211586 17977 21803 21808 21809 21813 21814 216080 100041766 66105 22196 22337 103573 76793 17869 227720 75465 67068 12399 54709 52563 69150 69957 12234 12442 230597 12505 24136 12530 22062 218210 13982 216869 433759 11651 14083 11835 18708 26411 12393 56484 14281 14282 16476 16477 20683 18607 20869 19645 22059 11909 12928 21402 12927 26965 12389 66513 18519 56438 26397 26399 56637 218441 23871 11910 19651 18706 13132 71770 68015 12567 12571 12575 12447 68999 22601 13018 26754 71728 12385 12386 17691 56458 268288 386655 104394 13805 18709 14030 14225 269338 14272 17872 97064 272359 99152 52206 15378 15405 15481 69260 16211 17128 17130 17258 17260 26413 12705 26417 18044 18045 18046 18102 56513 56371 59008 56317 94093 228026 18854 19042 71978 TCR%NETPATH%TCR TCR 107321 12519 12524 26558 73341 26431 12534 140580 14389 22388 27277 26396 12387 13548 11651 14083 18708 12912 11909 12928 56637 18709 26413 26417 19303 11486 16923 27387 19419 19395 56324 57257 98221 12608 20218 12469 71520 100039786 12675 30925 329693 83490 67300 26410 12914 12929 26416 12477 74039 13139 13205 13367 13430 94176 13448 12934 72349 269378 13653 13807 22154 13837 107508 19229 14158 286940 20430 320150 104248 12488 11350 23880 14381 101540 19260 14569 16797 54390 52013 53416 14784 107746 13169 232906 54167 12306 11744 432467 15516 81489 16150 16331 16428 16438 16453 12521 16818 16822 16828 16832 11857 240028 17085 17096 17829 17973 104112 18003 11928 18018 18019 232975 18033 18035 18036 18295 18479 20403 23853 77647 14026 56233 18613 227707 11431 18648 72157 240752 224020 18746 18803 234779 234374 233315 240754 74195 77853 170643 19056 18753 94212 56444 18760 59079 23939 26419 19094 26395 93742 140721 70737 15170 19247 19248 19262 19264 545902 11459 110157 19384 109905 218397 19697 71911 53378 24055 230126 20416 20491 20637 20662 20663 20779 20846 58231 20963 21682 22042 22088 22145 22165 50493 22323 22324 22325 22376 215280 22631 22637 108705 217069 22142 640703 72482 108723 72828 227937 78473 12402 208650 11502 192656 12523 54126 19134 12042 54353 68481 171543 13449 27371 19200 22248 12481 15239 13549 12500 12501 12502 16800 12504 12507 12516 12487 17444 LEPTIN%NETPATH%LEPTIN Leptin 20218 56637 12675 20416 105787 20779 20846 108079 18754 20112 20528 13649 18035 16370 13685 14360 606496 13684 667739 16367 16451 13866 17977 12568 12632 12944 20399 14682 192157 100705 18803 16001 234779 16419 16846 16885 18127 54611 11651 14083 12393 14784 26413 26419 13982 16150 16453 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor 13685 14360 667739 12566 11651 12984 14159 18708 15461 18750 15162 328572 16452 18751 26419 12703 16476 14786 20111 14191 58194 16590 16197 19247 22612 11909 56717 12928 17342 19273 67296 114715 110157 114716 13857 14936 218397 56150 19697 17179 17311 71520 56637 17698 19684 20850 29857 20851 18706 22350 67300 20662 21933 54607 20779 56468 12929 20846 26416 21682 22376 215280 11350 208650 26413 16331 16453 BCR%NETPATH%BCR BCR 13685 14360 606496 667739 12566 15162 18751 20111 12675 12572 12929 23921 26416 240354 208154 13712 14130 18717 240168 56792 19253 13448 14886 17060 15163 15387 16439 18021 77590 30955 18718 670717 242248 18761 12028 101476 83436 12053 20303 20848 12229 56743 117150 21432 18720 18719 108083 12369 14784 77799 107746 12371 17164 12483 12517 12518 15985 16150 16428 16438 16818 17096 17973 18003 18019 12387 18803 11651 14083 18753 12912 26411 18760 56484 14281 14282 16476 16477 18607 19645 15170 11909 12928 12927 218397 19697 56637 24055 20416 20662 20663 20846 21682 22324 22637 18709 108723 12042 26413 TNFALPHA%NETPATH%TNFALPHA TNFalpha 13649 16367 18750 328572 20850 14886 12028 12369 17164 21353 15185 72416 71833 56399 56338 544963 333654 18789 56532 14084 12539 67338 67067 100039026 446099 17846 11652 13057 56710 109658 14113 19698 211651 76589 19414 14229 69807 192176 103583 16650 11647 20019 56407 56312 29864 12091 20340 15182 71966 69721 56480 22627 11797 11796 11798 16535 100039592 16648 433759 16709 15507 17218 11651 17220 14083 26408 26403 12912 76784 50754 17931 18037 20018 18567 18616 16476 18637 16477 245841 100043714 54391 58994 19645 320795 23938 66593 21402 19173 19179 26965 19181 19182 12389 70247 66513 21762 22123 17463 66997 26399 23997 228775 19708 12051 77045 67891 432502 27207 12122 68015 57751 80859 64424 20586 20587 20588 68094 57376 21926 21938 22026 22166 22628 56458 22642 22682 231130 236733 12366 20017 224619 18201 16151 26572 56456 12905 14082 21934 12633 52440 12455 70834 233406 53376 211550 50797 21941 226525 26413 67384 20016 26417 22032 56489 73174 66413 23881 227648 216150 26406 666899 16396 228026 26405 18854 68652 66724 67857 26420 73086 19696 22034 230233 15519 14694 14388 12048 20181 54401 107951 13867 13728 22629 12367 22033 100041766 66105 22196 12234 100039786 26410 12914 26416 13205 13448 14784 15516 18033 18035 18479 26419 19247 20662 20663 20779 20846 22631 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 14388 54401 22629 13649 12367 13685 12015 14360 19353 18479 23844 12821 13684 109620 13844 16367 55948 13866 16403 192897 16418 11848 16773 16774 16776 22627 16777 16779 16780 226519 16782 16785 17126 11651 17127 14083 17295 11835 19882 18708 18753 18810 18750 20166 22352 213435 59079 18208 14281 12476 74769 16476 18707 18710 384783 22062 19247 22612 56717 100039786 20416 18706 20779 26416 22631 18709 30955 11350 14784 26413 26417 WNT%NETPATH%WNT Wnt 12443 54401 18019 13728 19353 216869 11848 18747 11651 18753 18750 18751 26419 16476 19052 17125 16842 18099 22612 16480 26409 226970 93687 13544 12550 13380 208846 67943 20378 14734 16971 16973 26563 18504 23988 19045 21416 84095 320790 77578 18752 12571 20377 20319 20664 13016 21413 22408 22413 22415 22418 14367 12005 14362 14366 14368 14369 14371 84035 330938 84505 18719 IL6%NETPATH%IL6 IL6 13163 26396 15519 17096 14388 14389 107951 13867 54601 18033 13685 12015 14360 19353 13684 16451 13866 17977 18803 433759 15507 11651 11835 18708 18753 15162 328572 56484 14281 26419 16476 26395 14191 19645 19247 18099 26409 26399 56637 20850 20416 20851 12914 20846 26416 22324 56458 18709 19229 54721 21939 229615 15382 16193 12402 16194 20848 16195 12229 26407 26398 12169 229317 20393 12702 14784 26413 26417 TSH%NETPATH%TSH TSH 26397 16001 26399 16846 12912 11928 14674 105782 14672 14673 14677 26417 14678 14679 14681 14828 22095 12317 16150 12330 110157 14682 EGFR1%NETPATH%EGFR1 EGFR1 13196 11949 67941 50766 72621 18596 54135 72201 18643 18738 67451 18805 18806 22038 74155 67760 109135 171463 212139 71889 216190 74255 321022 230837 19084 26362 18759 109333 66898 26400 19108 208618 19211 66166 76179 19246 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 667618 667279 110651 67097 20194 20195 20239 394252 20969 20971 140579 71514 56726 20408 319939 381126 114479 20617 107686 109552 109880 20847 20909 11491 21815 21881 21894 21961 22051 22330 66395 60595 24066 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 107435 30794 12390 56455 109711 54366 19766 101320 29875 22687 73178 29806 208177 232431 54132 194590 66952 23942 14924 21873 225870 333883 20970 98910 238130 17775 330914 78388 50926 26396 72993 13548 433759 14083 18708 12912 14281 16476 20683 18607 20869 22059 12928 12389 26397 56637 218441 18706 13132 71770 56458 18709 26413 54601 16478 17869 12608 20218 67300 12929 26416 13205 13448 19229 286940 11350 232906 16818 16828 17096 17973 18003 11928 18033 18479 20403 11431 18648 240752 18746 18803 234779 170643 18753 18760 59079 23939 26419 26395 93742 140721 15170 19248 19262 110157 19697 53378 230126 22042 22323 22324 22325 22631 108705 640703 72828 227937 208650 11502 54126 19134 68481 13449 13549 26431 12534 105787 108079 20112 13649 13685 14360 606496 16451 13866 12568 20399 18127 12566 15461 18750 16452 12703 14786 20111 58194 16590 56717 20850 20851 13712 19253 30955 12371 26406 666899 16396 26420 73086 14388 54401 13867 12015 19353 12821 109620 13844 192897 11848 17126 17127 17295 18810 22352 74769 18707 18710 384783 16480 226970 12550 18752 13016 54721 229615 15382 26407 12702 105782 54473 53859 12043 20844 100040260 12606 17979 319152 11820 12558 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 14251 74326 236576 24063 24064 57783 21787 67938 108100 24105 70527 12631 20499 229709 107971 327826 19765 20867 399510 56460 69710 232910 12757 73379 19261 71544 12988 216810 13014 12388 218518 74256 11771 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 11657 11674 240753 13855 229285 26936 98432 224650 23943 209039 22378 80794 14302 78757 235406 228136 104831 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 26934 11740 227753 13854 16952 15194 11746 215114 628438 11804 16332 16337 16400 16412 11836 67859 11843 16653 110308 16687 110310 16691 16667 16668 11855 16835 210126 109904 17709 17886 17920 17999 23980 50932 ID%NETPATH%ID ID 15205 18507 19185 19650 66313 26396 21423 11910 12566 19651 17127 21416 13712 26413 26395 26417 19645 13714 13713 14200 110157 15903 17877 IL9%NETPATH%IL9 IL9 26413 54721 26417 20850 81601 16199 20851 20852 IL3%NETPATH%IL3 IL3 56637 17096 20416 14694 14388 14389 12125 12048 14461 20181 56461 54401 19401 12929 20525 216233 18033 12015 606496 13448 56458 22631 18709 18747 12984 14083 14159 18708 15461 18750 12912 12702 18751 26413 18707 26395 19052 15170 12928 16331 19264 100040260 IL5%NETPATH%IL5 IL5 56637 53378 26396 20850 17096 20416 14694 20851 20662 20846 12929 26416 20963 18783 18033 12387 13712 11689 18035 16191 16185 16192 13430 606496 20677 15163 16451 22631 30955 19229 12028 12402 20848 15461 18753 15162 56484 14784 107746 12703 16476 20111 22248 19247 11909 110157 IL4%NETPATH%IL4 IL4 17979 319152 18033 18035 12015 15077 320129 56463 16189 16451 16163 16164 20375 12767 16186 234779 11651 14083 18753 328572 16452 26419 12703 19094 18707 384783 15170 19247 11909 12608 218397 12675 23871 20416 18706 12914 26416 20963 13712 54721 21939 12402 20848 26413 26417 16150 16331 20844 12606 IL-7%NETPATH%IL-7 IL-7 56637 26396 20850 20416 20851 20846 12015 14360 606496 16367 56458 16186 16196 208650 11651 20848 18708 56484 26413 26417 26395 384783 16197 16453 20844 NOTCH%NETPATH%NOTCH Notch 15205 11820 21423 18033 15182 13389 14357 14199 56381 59287 20466 19664 16450 16848 11651 17127 17305 18129 18708 18132 18133 18550 50754 328572 100039623 16452 54485 55927 433586 100042305 19165 19763 27401 17125 22632 16842 208117 270118 60406 66935 21402 20185 20602 26965 103806 18519 56438 19697 56637 20779 20848 26413 26417 IL2%NETPATH%IL2 IL2 26396 15519 17096 14389 18033 13685 16185 14360 13684 667739 16367 16451 16186 12566 11651 18708 12912 56484 26419 74769 16476 18707 26395 18710 384783 15170 19247 11909 56717 12928 64685 56324 110157 16432 23872 18795 19697 14815 16183 16184 16168 230126 23871 22608 20850 20416 18762 20849 20851 18706 21752 20662 22349 17346 27979 12929 26416 12447 13712 22324 18709 30955 19229 12402 20393 12702 14784 26413 26417 12043 16453 20844 16818 TSLP%NETPATH%TSLP TSLP 26420 19697 20850 11651 20848 20849 20851 20852 20846 18034 19698 26416 18033 18035 26413 26419 26395 26417 13684 RANKL%NETPATH%RANKL RANKL 19696 22034 12675 14083 18034 18383 26416 11973 83433 18033 22029 26419 22030 22033 22031 21943 18412 17342 26409 20375 66513 68652 IL1%NETPATH%IL1 IL1 67857 26420 26397 19697 26399 19696 22034 230233 12675 26416 18783 18033 18035 73914 13448 16175 16176 16177 16181 16179 108960 17874 18709 266632 30839 93834 67245 667310 93765 66589 16178 11651 18708 26413 26419 16476 26417 19645 11909 16150 54473 53859 26405 66513 68652 66724 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 12035 216136 12036 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 15275 216019 19895 110208 21351 21881 14751 15277 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 14073 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 238505 17768 22171 270685 13361 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 11676 11674 15275 16548 216019 230163 74246 14430 15277 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 17260 26398 13684 17261 102626 26416 100040260 22034 17164 29857 15507 19094 26415 26399 269881 13712 56613 13631 73086 17346 16177 66513 26407 26409 68652 20807 17347 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 102626 26416 17164 15507 26413 27371 26417 170758 22339 18710 110157 20698 75292 101540 21804 18127 216148 15251 19303 11836 109270 18704 240752 18751 107321 18783 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18708 18709 16542 18803 234779 18706 18750 74769 19353 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 11651 14083 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 20850 16155 20852 16154 16153 77799 20112 16188 16185 20728 16184 17869 16453 83430 384783 16165 12675 17164 16164 67071 16196 16195 16194 16193 12576 13712 16192 16169 16191 12575 17346 16168 16190 332110 16189 11652 110651 20807 17347 26413 26417 110157 18127 11836 18706 74769 18176 109880 11651 20111 50772 56484 23939 16150 20416 18607 16367 56717 20846 16183 20662 20848 13714 12765 227288 56637 23797 20663 14281 237313 20847 16173 20849 60505 16198 13713 20375 16175 16163 16162 16161 20851 100042555 16156 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 54391 319945 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 12892 237926 97541 17025 22275 14151 107508 19044 67417 15288 70383 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 11440 108015 108043 11444 110835 11438 110834 13491 13489 19045 192176 13822 269587 209195 210044 12288 19049 14677 14702 16527 223604 14688 214084 18747 12291 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system 18628 11865 12953 12952 12753 18626 18627 27373 104318 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 17855 20775 68603 14593 56075 110196 14137 16987 192156 100040592 15357 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 53623 14800 14799 110637 140919 14814 58234 14813 20511 14812 20510 14811 14810 20512 216227 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 68159 242607 108069 108068 243961 20513 22318 74732 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 103711 107272 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 12444 12445 67236 12447 68240 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 12447 30955 11920 18708 12566 18709 19650 22059 320207 12387 18706 22061 22062 74769 19211 18707 26416 19052 19053 234129 16653 29857 12450 18176 19645 19094 18705 26415 20437 12575 11651 11652 18607 18710 23797 18704 240752 225326 15461 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 208967 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 268860 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 18752 18755 18759 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 16440 14701 16439 14675 18798 18799 15465 18802 14682 74055 16438 114875 14672 18751 14702 18762 14688 18761 18753 18754 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 14814 14813 14812 14811 14810 18798 14809 14682 16438 14672 19084 19085 18749 108071 14805 14816 18751 66168 26556 19108 18747 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 12043 16476 17347 20846 17260 26398 17869 26416 29857 19094 26415 26399 13712 18783 22166 13631 17187 13198 17346 26419 26397 26420 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 14678 66066 11513 15557 19088 19087 15552 15551 15550 14681 14679 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 18749 210044 14677 14702 19108 16527 223604 14688 18747 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 18752 18755 18759 18803 234779 18750 18430 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 18751 14702 18762 14688 18761 18753 18754 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 14704 14696 14695 14693 11513 14709 14701 15562 14680 210044 14702 14697 14688 14710 14700 14708 14706 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 66066 11513 19088 19087 14681 14679 104110 242425 16519 12286 54393 12287 224129 432530 11512 11514 11515 14710 14708 14706 14704 14696 14695 14693 14709 19084 19085 18749 210044 14677 14688 18747 12291 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 56791 216080 22210 100041484 66105 100041766 68612 218793 22194 67196 620934 56459 50995 74153 22201 22193 22209 74244 53323 22195 93765 70620 22200 100039535 231380 22213 67128 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 22068 93735 17356 14367 14365 11464 11465 11475 14314 16974 22415 12387 14362 16973 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 13869 22408 57265 22419 12560 228357 93897 21416 22412 216795 66713 80890 22410 22414 22411 13542 19664 55992 58235 21415 22409 217127 12550 13544 13543 78943 238880 11459 22417 19668 94217 225372 16480 12505 11787 26946 16842 18128 11461 18129 18131 18132 56175 19164 19165 11820 56637 100042305 208117 23821 59287 81601 22063 22067 22066 16971 14725 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 72535 17161 107747 109731 216188 19378 237320 69748 56847 56752 14204 11671 110695 11668 11669 212647 11670 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 22059 17246 17248 22061 26374 22062 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 12035 216136 12036 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 68738 60525 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 68087 211347 106564 269614 74450 75735 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 11428 64602 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 26416 12675 29857 19094 26415 26413 16440 26417 16439 110157 16438 11836 18751 15461 26419 18753 26420 16476 19354 30955 234779 18706 74769 19353 18707 26395 26396 18176 16150 26414 57257 20662 15170 17096 22325 26405 19264 26406 22324 20663 640703 14281 20963 18038 17060 12229 14784 12518 12478 15985 12483 19055 19056 18035 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 105787 11652 64930 108079 19079 108097 18518 22059 22061 22062 23797 19052 19053 11651 58988 13685 22084 19082 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 16956 239759 18796 85031 18797 269060 18795 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 69080 331026 29858 54128 110119 218138 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 66585 70767 53607 20639 22184 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 11652 56717 23797 15251 11863 22346 12914 19885 56551 22166 112407 11651 112406 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 29807 105663 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 319944 14884 68705 98053 14894 68153 19088 74197 19087 12914 69833 245841 237336 14885 209357 21341 108143 66464 68776 20021 66653 22130 74238 72308 21343 328572 71828 229906 235459 24074 19084 83602 19085 100043714 407786 74044 66420 19183 21374 227606 208677 26427 208647 78284 63856 228980 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 14704 14696 14678 14695 14693 11513 14709 14701 18386 18976 14681 14679 210044 14677 14702 14697 14688 14710 14700 14708 14706 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 13088 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 76355 14583 14584 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 11998 18429 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 14645 266744 14661 UNTITLED%PANTHER PATHWAY%P00019 untitled 18796 18797 18795 11652 26413 16440 26417 16439 14675 18798 110157 14682 18127 16438 14672 19084 19085 11836 18749 210044 18751 18783 18762 18761 18747 18753 18754 18752 18755 18759 11513 19088 19087 18750 14680 104110 26395 26396 13615 13614 271639 13618 234889 224129 104111 432530 19091 11512 11514 54195 11515 60596 11651 19092 13617 13616 23797 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 15186 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 14287 22171 14528 13361 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 18752 18755 18759 66066 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 15560 14695 15559 14693 15558 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 18751 14702 18762 14688 18761 18753 18754 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 12831 16773 94216 12830 16774 241226 60595 11465 213119 225341 109711 11472 19248 16779 16780 226519 170736 16772 16782 78514 12841 12840 16775 16776 16777 319480 109905 223272 215449 286940 104303 228998 11858 140579 11840 12945 57342 16403 109700 16398 11845 11848 14268 373864 11852 53867 11853 104099 381924 16407 192176 16409 74194 223881 217378 238880 16400 16401 16402 16404 72065 192897 16419 74192 20130 26408 19229 16410 11461 16408 16412 12818 12927 16421 12816 12835 12834 12833 57764 22323 14360 67771 11867 56378 73368 76709 16420 21894 12817 71302 12815 12814 12813 16411 20779 56443 16414 12821 26414 26405 26406 26398 26415 26407 26417 18710 110157 19303 11836 18704 240752 225326 15461 26419 26397 26420 19354 30955 18708 18709 18706 74769 19353 18707 26395 26396 18176 109880 14083 50772 20416 107581 12819 16399 140580 13196 20662 12829 12828 12827 12826 12825 12824 12929 20663 107746 12928 16202 12843 23928 330662 320910 22330 12389 76108 74012 12839 329941 12837 12832 12988 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 20850 20852 20112 17869 16453 12675 78514 67071 332110 11652 110651 71302 218397 17973 18590 18591 18595 18596 71520 14390 76117 26414 68797 57257 17974 19326 71544 22325 14247 26405 232441 259302 216445 22324 17444 69257 13709 606496 94190 13710 14784 78177 75415 13876 13875 171207 11855 11856 320119 58988 13711 56501 27049 30051 13661 56309 16451 260298 22282 18080 54153 230233 14389 320207 114713 14388 20418 109333 16452 117600 17164 13712 56613 73086 17346 26407 20807 17347 26413 16440 26417 16439 18710 110157 16438 216148 11836 225326 15461 26419 16476 30955 18708 18709 18803 234779 18706 18750 74769 18707 26395 26396 18176 228359 109880 73167 23871 20111 50772 23939 16150 20416 18607 20846 20662 20848 13714 56637 20663 14281 20847 20849 20851 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 11464 11465 11475 140781 17885 17886 71960 329421 63993 20508 102857 667772 432516 17913 504186 54130 226977 17909 360013 11443 213603 110902 11435 17910 338367 71602 17918 17919 17920 17921 17922 270163 246177 17916 11449 208943 11448 11447 17912 238880 244281 11459 217198 231252 74376 667663 17879 544791 77579 17880 17882 17883 17884 11440 11461 17888 108015 108043 11444 110835 11438 110834 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 20850 20852 16451 20849 20846 20848 16453 20851 16452 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 192136 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 236539 100678 107272 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 19354 107449 30955 69581 18708 18209 18709 226251 18021 18803 320207 73181 234779 57764 22253 18706 22323 18208 18019 74769 19353 80883 18707 13176 210801 18710 18704 240752 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 229706 102680 22598 381884 110877 13162 103098 20538 74338 214084 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 13087 21743 22236 394433 14262 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 192136 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 238505 11720 232087 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 11464 11465 11475 140781 17885 17886 71960 329421 11853 238880 11459 667663 17879 544791 77579 17880 17882 17883 17884 11461 17888 19354 69581 19353 67771 11867 56378 76709 56443 73710 545486 13367 16885 100042651 214230 107589 19877 18479 18481 224105 68089 22151 241656 22154 54004 18643 70584 18645 75477 213435 19878 22152 227613 22153 12632 12631 16765 228785 73178 67951 56471 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 16004 16370 16002 16001 16000 16334 20112 16337 23920 384783 26395 26396 67071 13712 56613 73086 20111 218397 110651 26413 16367 26417 20662 110157 20663 14281 58988 26397 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 16451 20846 15979 15980 15978 16452 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 13195 21990 216343 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 66757 331487 80914 22245 22271 68556 76654 18103 79059 56520 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 53611 56216 12295 14697 20907 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 19084 19085 18749 108071 14816 14677 19108 14688 18747 14678 19088 19087 14679 12286 271639 12287 53623 14800 14799 110637 14814 14813 20511 14812 20510 14811 14810 20512 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 242607 20513 22318 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 16004 22059 26398 100040260 12675 11798 11652 12018 228355 19697 26413 19698 13804 26417 26926 12028 13665 26400 11910 11911 223922 19696 71609 14082 23992 21926 14939 225028 16994 53859 12125 14102 18751 14103 12048 19106 11783 16992 26419 12367 18761 26397 12124 18753 26408 26420 13163 18754 12043 26401 18752 66593 18755 16476 21937 21938 22035 30955 226641 26412 14943 81703 12369 18706 12370 18750 12915 74769 11909 19766 18707 11797 670717 12905 22030 18033 18034 26921 21933 11796 12371 11651 16150 26414 23797 14281 18035 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 12035 12036 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 20112 26398 102626 26416 16653 17164 29857 67071 19094 26415 26399 13712 26407 110651 20807 26413 26417 170758 11848 26400 110157 11852 11853 11836 225326 15461 26419 26397 26420 26401 16476 19354 30955 18706 74769 11909 19353 18707 26395 26396 18176 109880 19730 21844 18805 23871 18806 11651 56044 64143 20111 19731 66482 20416 18607 26414 20846 20662 18479 20848 18481 224105 56637 23797 20663 606496 14784 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 66066 18750 26395 26396 18796 13712 18797 18795 14697 14710 14700 14708 14706 110355 14704 320129 14696 13653 14695 11606 14693 11607 26413 14709 109689 16440 216869 26417 16439 110157 14682 16438 14688 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 319944 14884 68705 98053 14894 68153 74197 69833 245841 237336 14885 209357 21341 108143 66464 68776 20021 66653 22130 74238 72308 21343 71828 229906 235459 24074 83602 407786 63856 228980 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 12447 11920 12566 22059 18706 22061 22062 19211 234129 22030 12914 17246 17248 12575 11651 11652 18607 100043858 93759 12578 55948 12534 434174 20610 100043429 328572 23797 29870 17873 13197 18519 22427 433759 20466 23882 12532 23942 50883 18854 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 12297 12298 18796 18797 18795 12295 14697 14710 14700 14708 14706 12290 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 18751 14702 18762 14688 18761 18753 18754 18752 18755 18759 18803 234779 18750 12286 12287 20614 22320 20619 67474 22319 22317 12296 20908 22318 22044 22045 22094 12640 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 20652 15486 15487 16889 15485 27400 13075 223920 15490 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 93735 14367 14365 11464 11465 11475 14314 22415 14362 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 66713 22410 22414 22411 21415 22409 12550 238880 11459 22417 16842 11461 12387 75599 93701 93706 54216 19246 233651 93893 93889 270120 93886 93891 18526 93887 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 93873 353237 353236 73173 192164 353235 170677 12939 12937 12941 18163 12388 12936 192163 353234 93881 116731 12558 23836 279653 245578 215654 320873 12565 12564 241201 12563 93872 12562 93724 12561 12552 268663 18530 211712 245827 14107 12557 12556 12555 12554 22295 219257 239096 11994 14158 104010 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 UNTITLED%PANTHER PATHWAY%P06664 untitled 19697 20482 21815 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 76507 237940 11754 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 18598 66052 12974 14194 18293 18604 56451 11429 18597 17449 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 11947 11949 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 54375 242669 18263 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 66904 17850 52665 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 79464 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 65254 23959 12934 64705 72269 268860 99586 103149 104776 22240 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 66646 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 14704 14696 14695 14693 11513 14709 14701 11554 19088 19087 14680 18749 210044 14702 19108 14697 14688 14710 14700 18747 14708 14706 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 16004 16370 64930 16002 16001 18607 16367 16000 16334 16337 56458 23920 18706 19211 56637 384783 234129 606496 17246 17248 22084 56484 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 14704 14696 14695 14693 11513 14709 14701 19088 19087 15466 14680 18749 210044 14702 19108 14697 14688 14710 14700 18747 14708 14706 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 14704 14696 14695 14693 11513 14709 14701 11556 14680 210044 14702 14697 14688 14710 14700 14708 14706 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 23959 14544 11717 22436 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 238505 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 14704 14696 14695 14693 14709 14701 14675 18976 14682 12922 12921 14680 12918 14672 14702 14697 14688 14710 14700 14708 14706 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 18752 18755 18759 56175 19164 19165 11820 18750 109333 26416 225724 319924 11784 29857 12289 54652 19094 12292 26415 74764 57267 320795 16594 12295 263803 232943 16593 11491 50772 332110 23939 26413 26417 26414 100042305 12288 208117 18751 23821 59287 81601 12296 18762 26419 18761 18753 26420 18754 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 12411 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 19876 20563 11350 19354 20564 20562 20315 18209 57764 18208 19353 11853 80883 13176 117600 12767 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 227231 69719 18103 114873 51797 56749 55936 18102 79059 56520 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 20850 20852 54153 320207 14389 26398 114713 14388 20418 26416 29857 19094 26415 26399 13869 26407 11652 26413 26417 26400 110157 75292 101540 208177 17532 13649 216148 210710 13867 13866 11836 69601 236576 18704 226525 240752 24066 18751 24064 18015 24063 18762 66922 225326 23980 15461 73523 26419 18761 20130 26397 18753 26408 26420 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 18760 109880 11651 218397 20416 71520 26414 20846 20662 20848 26405 26406 23797 20663 20847 20849 20851 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 18816 17386 14161 83995 17395 18791 18792 18793 18815 17392 110135 99571 18787 18788 PNAT%PANTHER PATHWAY%P05912 PNAT 14678 66066 11513 19088 19087 13491 13488 14687 14679 13823 19047 13492 13162 14706 14704 14696 14695 14693 14709 20614 22320 13489 20619 19045 67474 192176 22319 13822 22317 269587 18749 209195 210044 19049 14677 19108 16527 20908 223604 14688 22318 214084 18747 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 12234 269209 14634 19206 14632 319757 103583 12914 24069 20423 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 14678 66066 19088 19087 14681 14679 16519 271639 63993 20508 102857 14686 16521 14697 16522 14710 16524 14700 14685 14708 12672 14706 243764 14704 14696 14695 14693 14709 19084 19085 18749 14677 19108 14688 18747 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 26384 74091 245847 67980 14583 14584 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 16324 18119 16323 110542 12705 320202 21809 21812 21813 17684 66313 242316 269275 17129 26416 17130 17131 55994 21808 29857 14573 238057 19094 319618 26415 14560 11477 11479 12914 11480 11481 11482 14106 14283 75788 66513 24087 21892 26409 14561 12153 20481 26413 26417 328572 15461 26419 20130 26420 16476 11909 18176 16477 20482 16478 26414 12154 16326 12163 12156 13590 110075 76793 12159 12160 12161 12162 12166 12167 23886 12168 14563 12155 17125 14562 17126 17127 17128 14566 17700 16325 12165 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 14161 18791 18792 18793 18815 110135 22371 21788 21824 16399 14060 58992 14724 14723 385643 14058 14071 14069 217847 66901 19123 54368 19128 14729 14062 19124 14065 14068 14066 16621 14061 99571 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 14678 18708 16337 18709 56458 320207 18706 14679 74769 18176 14686 12371 14697 11651 14710 56484 11652 14696 14695 14693 18607 16367 14675 20662 18710 14682 56637 23797 20663 18127 14672 14677 14699 19216 14688 58988 54601 22631 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 11554 15466 11556 109905 215449 14823 108073 268934 13489 210044 14677 14702 14688 18747 13491 13488 13492 16521 16522 16524 12672 243764 640703 606496 108069 108068 12914 14710 14700 14708 14706 14704 14693 14709 14701 15465 328572 19084 19085 18749 108071 14816 208677 14699 26427 208647 78284 68961 20605 20607 20606 14678 15566 15565 11513 15563 15557 18682 19088 67300 19087 18386 74325 15552 12757 15551 14715 15550 20609 20608 14679 14765 11539 15562 11540 14680 11541 104110 18387 110078 16519 18389 110095 19309 12671 224129 11542 432530 104111 12669 11512 11550 11514 12913 11515 213788 232493 14936 225192 17773 244701 15560 18679 15559 110094 15558 102093 99296 11552 11553 11548 11549 18390 12912 11555 56637 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 54153 26398 114713 20418 26416 29857 19094 26415 26399 26407 11652 26413 26417 26400 110157 11836 236576 18704 240752 24066 18751 24064 24063 18762 225326 23980 15461 26419 18761 26397 18753 26408 26420 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 11651 218397 20416 71520 26414 20662 15170 26405 14182 107971 26406 53608 23797 14186 20663 14183 14184 327826 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 109900 18416 217214 227231 11898 69719 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 20028 19739 18587 18588 14697 14710 14700 14685 14708 14706 14704 14696 14693 14709 14701 640703 64337 212541 14702 24013 225600 14699 12790 12788 14688 70405 30952 19674 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 12035 12036 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 12447 20617 19171 18951 18952 100039786 21823 26446 12448 22628 22627 26416 19177 22629 100226 12361 29857 50873 53331 26443 13162 67847 26444 19170 13712 54401 18000 18806 26440 19166 19167 26441 26442 332110 171469 23939 72900 54204 14763 26413 26417 26414 55948 26419 22631 26420 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 18752 18755 18759 66066 18750 109333 63993 20508 12671 12669 320795 263803 14697 14710 14700 14708 14706 14704 14814 14696 14695 14813 14693 14709 14812 16440 14811 16439 14810 14675 18798 14682 16438 14672 18751 18762 14688 18761 18753 18754 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 14704 14696 14678 14695 18610 14693 18619 11513 14709 14701 18386 14679 210044 14677 14702 14697 14688 14710 14700 14708 14706 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 19075 19891 21973 21974 18538 19687 19718 18968 69263 319152 21969 327762 15081 106344 18971 72151 18972 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 73724 110821 66904 17850 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 20135 20133 231327 75533 382985 11636 11637 229949 635960 229363 14450 54369 68870 79059 56520 18103 114873 18102 56248 171567 108147 100042069 11565 14923 11564 11566 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 19401 14060 20181 22337 14473 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 18796 18797 109905 18795 215449 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 16440 14701 16439 14675 11848 18798 14682 13489 16438 14672 217378 108071 14816 18751 14702 18762 14699 14688 18761 18753 18754 20605 18752 20607 18755 20606 18759 18386 67300 13491 74325 12757 14715 20609 14681 18750 13488 20608 11539 11540 13492 11541 18387 19395 93690 18389 233046 12286 12061 12062 12287 12671 99326 11542 19419 12669 240168 110351 16801 213788 12672 243764 18390 64337 108069 108068 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 14367 14365 14362 22413 22418 22422 22421 22408 57265 22419 11652 21416 22410 22414 11848 13542 19664 11852 11853 22409 13544 13543 19668 18128 26401 18129 18132 18805 18806 20779 13449 13388 50915 11799 218397 14786 17973 13448 18590 14164 18591 16449 18595 13389 18596 27261 71520 13386 13837 12005 78390 17974 13845 54635 13844 270190 21414 23805 232889 16450 21687 11600 71785 54485 11789 13642 13641 16451 26398 12387 102626 26416 17164 15507 26413 27371 26417 22339 18710 110157 20698 75292 101540 21804 18127 216148 15251 19303 11836 14062 109270 18704 240752 18751 107321 18783 18762 225326 15461 18761 26419 18753 18754 18752 18755 16476 18759 30955 18708 18709 16542 18803 234779 18706 18750 74769 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 11651 14083 20416 20846 20662 18479 20848 18481 224105 14182 107971 56637 23797 12929 20663 14281 12928 327826 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 20135 66757 20133 22171 382985 18103 21915 114873 110074 18102 79059 56520 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 54524 171180 53420 13852 208898 54525 319508 20981 20980 20614 22317 56216 70450 19339 20907 22249 20910 20979 229521 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 56458 54401 110651 12028 11848 12550 53859 14702 12048 14688 214084 12367 18747 19229 16410 16412 12927 18792 17392 11909 20779 13653 216869 26414 17096 640703 14784 19055 18035 13685 252972 17260 26398 20613 12387 19247 13684 26403 17261 14919 667739 26416 16452 18125 233979 22034 12759 12424 15507 12426 110596 22026 15568 26399 12326 13712 21413 20192 20191 11640 20190 23938 67605 20687 12494 56233 20683 20807 22612 26413 19225 19016 26417 15937 12015 14459 15200 110157 101540 16438 19303 11836 18749 18751 18783 18761 26419 18753 18754 26420 12043 18755 16476 18708 18803 18750 74769 18019 19353 26395 26396 18760 109880 432530 19091 11651 14083 20111 56484 23939 20416 18607 16367 19877 20662 18479 20848 12912 13714 56637 14281 12928 18263 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 11674 12183 18746 18655 21991 18641 18642 56012 13806 13807 100043349 18770 15275 216019 14751 15277 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 18129 18131 16449 18132 13389 13386 19664 16450 54485 18222 66935 103806 19668 20602 18128 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 268860 14417 14415 246277 214579 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 14084 12368 16476 235587 11546 16905 16906 11545 328417 12332 12633 12369 26398 227753 12370 12371 26414 14082 14102 14103 11783 16907 26419 12367 13368 26408 20259 26420 13163 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 11464 11465 11475 15978 12675 12361 12767 11652 19697 19698 11848 11853 238880 210044 11459 14677 14702 74192 20130 18747 19229 11461 16408 16412 12818 16421 12816 12835 12834 12833 67771 11867 56378 73368 76709 18034 56443 71520 16477 16478 22324 16452 140781 17885 16653 17886 71960 329421 18796 18797 18795 14700 14708 14706 14704 14695 22371 14709 26413 16440 14701 26417 16439 14675 18798 110157 18799 18802 14682 74055 16438 114875 14672 11836 18749 18751 667663 19108 17879 18762 544791 77579 17880 17882 17883 18754 17884 17888 16476 14678 19354 30955 18803 18021 234779 73181 18706 14681 56212 14679 74769 13051 18019 12769 19353 18707 18018 56744 54199 14294 14293 18176 12273 15975 54446 224129 15945 20303 11512 20304 20306 20296 20292 11651 277360 57260 20293 23832 20302 16150 12777 20416 20297 18607 100038965 12772 214230 20299 107589 12768 19877 16183 12766 20662 18479 12145 20848 18481 80901 224105 20312 12765 12776 68089 227288 12775 12458 241656 23797 12774 12773 12771 12322 70584 108058 213435 228785 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 18950 15452 14544 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 104215 110082 12333 12334 12335 12336 11464 12338 11465 13417 11475 54152 22059 29816 26398 13427 13426 22061 22062 73916 100042162 80837 76884 13424 66445 11771 11772 234663 12337 545156 269881 15194 12914 14447 68097 268958 20430 12339 23830 12064 20683 66713 26400 328572 100043349 238880 11459 21374 11783 74192 12367 26420 228980 11461 16476 19354 74325 12370 56212 19353 67771 11867 56443 110637 73710 545486 14814 14813 100042651 14812 14811 14810 14809 22151 22154 14281 14807 14806 56455 14805 381917 22152 110350 227613 215114 22153 432611 13385 15114 235661 13191 73647 67951 69543 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 94041 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 18563 18598 104112 17436 12974 69634 18770 18534 18746 18597 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 12675 11652 26413 19057 26417 16797 12500 12501 18710 12502 110157 12503 16822 22637 16818 12487 12519 16438 12524 11836 225326 15461 26419 18761 26420 26401 16476 30955 18708 18709 18803 18706 74769 19353 18707 26395 26396 18176 109880 11651 17973 16150 57257 20662 17974 18479 18481 224105 22325 19264 23797 22324 17444 20663 640703 14281 19055 19056 18035 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 26410 56480 16476 26940 170744 266632 81897 26416 26395 22034 12675 26396 13712 66513 26409 16150 26417 17874 56489 117149 18037 54131 106759 54473 170743 21353 16179 21899 18035 21898 142980 26419 225471 26397 24088 26420 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 216134 103711 107272 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 19057 14702 14688 67155 93761 20586 20585 20439 20588 20587 27373 13001 104318 13000 73016 12234 21372 70425 103236 93687 140577 75560 103583 12385 12386 68058 93762 216033 54380 59036 77578 20215 68094 83796 83797 57376 66993 68142 100043597 226849 225849 26931 21770 26932 84035 19058 19059 114606 170735 70315 81004 18099 93760 15183 21885 17125 21886 54366 21888 21887 17128 68911 15182 15201 72135 12387 17129 19052 19053 20437 18796 18797 18795 14700 14708 14706 14704 14696 14695 14693 14709 16440 14701 16439 14675 18798 14682 16438 14672 18021 73181 18019 64337 93735 14367 14365 14314 16974 22415 14362 16973 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 22410 22414 22411 13542 21415 22409 12550 13544 13543 22417 16842 109689 216869 12005 433759 19055 19056 75599 93701 93706 54216 233651 93893 93889 270120 93886 93891 18526 93887 12914 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 93873 353237 353236 73173 192164 353235 170677 12939 12937 328572 12941 12936 192163 353234 93881 116731 12558 23836 18751 279653 245578 215654 18762 320873 12565 12564 18761 241201 18753 12563 18754 93872 18752 12562 18755 93724 18759 12561 12552 268663 18530 211712 245827 14107 12557 12556 18750 12555 12554 22295 219257 18018 239096 11994 104010 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 56637 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 11821 18950 15452 22436 11486 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 15450 16890 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 14678 66066 19088 19087 14681 14679 12286 271639 12287 56216 14686 12295 14697 20907 14710 14700 14708 12290 14706 14704 14696 14695 14693 14709 20614 22320 20619 67474 22319 19084 22317 19085 18749 14677 108069 19108 108068 14688 22318 18747 UNTITLED%PANTHER PATHWAY%P05916 untitled 14704 14696 14678 14695 18610 14693 11513 14709 14701 14681 14679 11998 18429 18387 210044 14677 14702 14697 14688 14710 14700 14708 14706 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 65254 12934 20354 64705 19354 14302 18186 18844 235611 11848 26757 18479 20346 14159 12568 14360 12933 19353 16801 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 14704 14696 14695 66066 14693 14709 14681 14679 12801 12286 12287 108071 14816 18796 14677 18797 18795 14688 14710 14708 14706 12291 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 237336 21341 22130 21340 21339 21429 17749 20018 19285 106298 20017 19183 21374 227606 63856 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway 216134 103711 SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 66757 72269 21877 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 14704 14696 14695 14693 11513 14709 14701 19088 19087 11555 14680 18749 210044 14702 19108 14697 14688 14710 14700 18747 14708 14706 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 14678 11513 19088 18386 19087 14681 14679 14680 14697 14710 14700 14708 14706 14704 14696 14695 18610 14693 18619 14709 14701 18390 12912 18749 210044 14677 14702 19108 14688 18747 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 27053 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 18752 11552 11553 11548 11549 18798 18750 74055 16438 14672 18796 11551 18797 18795 18753 18754 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome 11677 12408 19286 320415 14528 110391 20751 13361 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway 100038824 11606 11421 ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway 16542 THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate 55951 269951 66945 112407 67834 112406 18563 66925 27376 56451 209692 20917 14194 11429 13382 15926 235339 11428 68263 15929 170718 18597 67680 78920 66052 12974 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 13382 110446 12039 68738 12040 268860 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway 15452 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway 14815 15519 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId 14430 216558 76025 14377 66588 16770 22232 20525 14595 18103 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway 12675 26416 26401 22034 18033 18035 16151 22031 16150 19252 21929 21939 21947 230233 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism 56717 56208 18711 16329 71780 55980 74769 56727 269180 66461 234729 75669 69718 18798 224020 228550 83493 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency 19895 71336 14121 21351 14381 18641 21881 11674 19139 14751 CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway 100038824 11606 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism 70974 72157 110006 14936 11722 77559 14387 216558 22235 110095 14751 223337 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 18563 13382 235339 68263 17449 18597 110446 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 17436 76238 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway 107141 11668 14863 13114 13088 13087 72303 11670 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 98314 216456 269951 66945 67834 18563 66925 56451 209692 20917 14194 11429 13382 15926 235339 11428 68263 15929 170718 18597 67680 78920 66052 12974 14661 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency 110006 22239 15275 14751 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway 20963 19353 16818 14784 16797 20416 26419 14281 110157 26401 13712 15461 18033 16476 18035 18708 26400 14360 26395 12313 19055 19697 26417 320139 19419 54446 22190 12502 12503 19056 12500 18750 18803 18751 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway 26357 18984 624814 18671 17250 22436 105349 19765 18104 75406 18127 58810 109857 12780 12408 70840 226646 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling 14661 15109 13382 216456 227231 231691 66514 434437 14645 27053 11833 104174 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 12289 54652 12292 26413 110157 18033 15461 18035 12288 26395 16438 19697 26417 18750 18751 18795 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway 16334 12286 20526 56808 12295 20927 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor 16438 14682 18750 18795 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism 54342 15275 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism 13649 56208 52858 18711 18704 13866 18720 228361 225326 234515 18707 234729 75669 18708 19211 64436 104015 18718 224020 103199 18795 16331 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency 14121 14381 66171 18641 21881 75456 11674 14751 72157 19895 71336 21351 66646 110208 232449 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis 232087 20810 108645 671878 18263 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism 100038824 11606 11421 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation 14651 109801 52815 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria 14121 21991 18641 11674 218138 11677 69080 67883 29858 18639 110119 20322 16548 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 63959 434203 13178 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway 243764 11933 11938 13077 58226 394433 11928 71853 18747 69191 16521 12846 67838 98660 394434 16535 12304 12291 394436 16493 19035 330953 64136 16523 12282 20927 67397 16514 14828 20271 22004 13849 16519 94284 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 107141 13114 18104 13383 16511 20191 20928 246133 13106 232975 19084 20649 20648 11931 11932 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis 14430 216558 76025 14377 66588 16770 22232 20525 14595 18103 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism 54369 320685 76952 69719 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 110074 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) 52538 93747 11363 110446 15107 11409 15108 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine 67248 97541 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway 12780 18671 17250 545486 19765 22143 22059 224814 76408 12575 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease 16922 11671 26874 11666 26458 56794 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway 100038824 11606 11421 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency 54369 320685 76952 69719 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 110074 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis 22173 13190 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 107271 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome 18642 15277 100043349 14377 13806 18770 21991 56012 319625 11674 14751 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary 14121 21991 18641 11674 218138 11677 69080 67883 29858 18639 110119 20322 16548 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway 13114 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway 100038824 11606 11421 INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 18749 19045 12912 14699 14701 14688 14309 12640 210044 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency 21823 18948 13195 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism 117147 107146 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle 11826 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism 55980 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) 66461 14732 74451 14555 110911 66586 52123 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway 20517 12780 13114 13088 56448 394434 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms 12753 18160 18626 27373 12952 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway 20963 19353 17060 16818 14784 17096 15985 20416 109305 26419 14281 110157 26401 13712 15461 16476 26395 12313 19055 26417 54446 19056 18750 18803 18751 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins 15560 14699 14682 14688 22141 18795 12669 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 20115 319195 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine 67248 23874 66590 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway 100038824 11606 11421 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease 14377 100043349 12183 13806 20526 56012 319625 11674 14751 18655 18648 18642 15277 18770 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway 13077 13114 13087 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 94284 20859 14871 27416 239273 231396 20860 20887 26357 56448 18671 17250 13106 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation 66904 110821 13171 13382 231691 17850 12039 12040 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 100039707 270685 14287 52466 17769 69606 108156 667301 107747 14317 13361 17768 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway 17001 19223 13850 13114 100040843 13088 13110 16993 11684 394434 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 56448 12408 72303 14598 13106 72054 66469 71519 14775 208285 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 234734 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway 12780 18671 17250 545486 19765 22143 22059 224814 76408 12575 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain 17708 11947 66925 670717 100039108 11949 22273 54405 100043349 11739 14385 17705 11946 67680 66052 66043 11950 66945 14571 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism 56316 18104 27973 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway 20264 13077 13114 20266 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism 110948 100705 26363 69019 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 76282 55963 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway 100038824 11606 11421 OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism 11677 72157 74246 14430 226413 216558 12091 14387 11605 14377 15275 14595 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway 13114 13106 11670 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism 71780 55980 234515 17330 269180 56409 27399 170835 217837 75678 23827 69718 228550 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism 93747 15356 117147 67041 110446 15107 11409 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome 14719 69719 97541 231327 216456 54342 14415 14630 14661 268860 67417 56174 212647 14629 14782 14583 14854 214579 227231 14645 76282 229363 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway 68603 100040592 319554 14137 16987 192156 15357 17855 110196 20775 110446 BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I 18746 100043349 21991 56421 14751 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency 19895 71336 14121 21351 14381 18641 21881 11674 19139 14751 PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis 192654 19210 52858 12647 56209 13139 18618 66461 14732 74451 14555 66586 19012 320951 18782 237928 74596 18806 55979 27388 18777 12660 14571 13026 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway 109828 230558 12279 15139 14962 18636 12266 12274 11537 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway 107141 13114 56448 15567 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism 11605 18605 22234 20773 67630 53418 22239 56632 230379 242285 223753 70059 268656 14466 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) 11677 12408 19286 320415 14528 110391 20751 13361 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides 22178 20657 20656 667310 12359 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway 100038824 11606 11421 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect 69719 55951 13806 104112 66945 67834 64602 66925 20501 20916 14194 18293 18663 27402 15926 12183 11428 15929 15275 17449 67680 66052 12974 14751 12040 14447 14661 18746 14782 239606 14660 18642 19895 100198 21351 110208 83553 11676 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway 13114 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway 12780 13114 18671 17250 545486 19765 22143 22059 224814 76408 12575 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway 16337 20851 26413 16367 16334 15170 12703 20528 14784 14600 20111 20416 20662 20850 16452 110157 15461 26395 26417 18750 18803 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct 20277 11933 11928 98660 11827 110935 27411 20533 100038824 11828 12346 20278 232975 20276 11931 11932 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle 100043349 14555 14571 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia 11677 12408 19286 320415 14528 110391 20751 13361 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome 18563 13382 235339 68263 17449 18597 110446 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 17436 76238 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism 225326 18707 74055 66461 101490 234729 75669 16332 218441 277360 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 22321 319195 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) 13163 12368 19090 16905 16906 14082 12633 26409 18479 11545 11857 12370 12367 13347 26419 19645 12369 26401 26398 19249 224105 16476 16907 13368 14102 20740 14103 192656 14084 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I 18563 55951 224805 76282 11611 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency 11677 12408 19286 320415 14528 110391 20751 13361 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle 19895 21991 66646 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway 13869 18750 13867 11491 19164 100042150 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway 100038824 11606 11421 FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway 17001 107141 19223 13850 13114 100040843 13088 13110 71853 16993 69191 11684 67838 106648 394434 105349 12304 64292 394436 19215 19035 11689 64136 11686 12282 21391 67397 11687 14828 11688 19224 19225 18399 22236 19879 12408 71773 72303 14598 13106 72054 66469 71519 14775 208285 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule 30962 54403 20532 20544 11826 69354 50934 18399 20510 12346 102680 20518 20540 330836 17254 20539 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway 13856 13857 15170 14784 20416 20662 26419 20850 14281 16452 110157 13712 15461 16476 26395 26417 18803 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway 13114 56448 18390 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway 11421 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway 72157 19895 14121 14381 18641 66171 66646 230163 21881 232449 19139 14751 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development 20807 74318 18091 14463 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism 14629 14782 14854 68214 75475 16790 71522 14775 68252 14630 12369 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease 12091 11605 14420 208449 22234 66190 20773 11883 50877 22239 70750 56632 20397 19012 56386 223753 433323 70059 53897 268656 238011 14466 171168 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency 268860 104776 11669 64705 99586 11754 103149 338403 14415 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell 19339 55984 14652 271639 12286 20526 20927 14702 56808 14682 18750 12671 12295 56508 14688 22318 18795 16440 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 18749 19045 12912 14699 15565 14688 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway 107141 13114 13088 56448 72303 18390 13113 14811 14810 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism 216443 232087 20768 23971 269378 67547 67011 14598 12411 50880 108645 107869 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 18749 14699 14688 19214 210044 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism 66681 14376 14936 216019 15275 74185 14751 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 107271 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling 11651 19877 432530 20807 78134 16438 14702 14688 18795 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria 54342 15275 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism 29807 105663 116914 66566 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease 12091 11605 14420 208449 22234 66190 20773 11883 50877 22239 70750 56632 20397 19012 56386 223753 433323 70059 53897 268656 238011 14466 171168 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency 20860 78925 208665 15497 15487 15485 13075 54200 100559 13074 ARGININEMIA%PATHWHIZ%PW000183 Argininemia 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 76282 55963 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 27053 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 110157 15461 18033 18035 26413 26395 16438 19697 26417 18750 18795 18751 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 68738 60525 72535 11669 13106 11670 12359 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 26413 20851 16334 16367 15170 20528 14784 14600 20111 20416 20850 16452 110157 15461 14599 26395 26417 18750 18803 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism 18563 55951 224805 76282 11611 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency 13382 110446 12039 68738 12040 268860 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III 72157 67883 74246 14430 216558 22235 103988 14635 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway 11651 22324 30955 104709 18750 18803 18795 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging 226518 12753 59027 18160 93759 18104 66454 74080 19883 192185 19017 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 18749 15566 19045 12912 14699 14688 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway 14815 15519 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 76282 55963 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway 107141 22236 19879 13114 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 19224 19225 71773 18399 72303 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis 18746 18648 100043349 13806 21991 56012 15275 20525 319625 56421 14751 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway 107141 20538 13077 13114 56448 15567 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 100040287 16520 19088 11554 215999 16518 67821 12288 19085 20541 19087 20650 56543 16525 16509 56808 12295 18749 20544 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway 107141 18549 11933 20264 13077 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway 14262 394433 13088 13087 11761 11444 110834 11438 394434 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis 20425 56752 170442 73251 192289 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency 11677 19012 235582 14732 55979 14555 16956 15450 50784 14571 11670 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism 14719 69719 97541 231327 216456 54342 14415 14630 14661 268860 67417 56174 212647 14629 14782 14583 14854 214579 227231 14645 76282 229363 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 63959 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway 18102 11637 11636 18103 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 63959 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism 14718 14629 12583 83429 27267 246221 16828 107869 14630 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway 13649 14784 20416 26419 14281 26401 110157 26398 13712 15461 16476 26395 26417 20807 20847 20846 20848 16451 100039026 13645 20662 218397 20852 18750 18803 18751 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism 100039707 270685 14287 52466 17769 69606 108156 667301 107747 14317 13361 17768 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation 14121 21991 18641 11674 218138 11677 69080 67883 29858 18639 110119 20322 16548 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) 12411 107869 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism 57028 216134 11647 103711 11761 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism 72157 67883 74246 69976 14430 216558 22235 15275 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway 100038824 11606 11421 PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency 14629 14782 14854 68214 75475 16790 71522 14775 68252 14630 12369 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 216443 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway 104158 72269 72962 22171 434203 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism 22173 54391 319945 11431 18605 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway 18549 11933 20264 11928 71853 69191 67838 98660 394434 12304 394436 19035 64136 12282 67397 14828 231396 56808 12295 22236 12286 13162 71773 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 52538 93747 11363 110446 15107 11409 15108 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 76282 55963 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis 19012 14712 99712 228061 55979 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency 20887 211389 23972 23827 58250 54200 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway 100038824 11606 11421 CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway 15466 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway 19224 19225 13114 56448 394434 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway 18102 11637 11636 18103 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation 11933 11928 103988 98660 20526 232975 20537 11931 11932 58866 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism 18563 13382 235339 68263 17449 18597 110446 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 17436 76238 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway 109731 107141 17161 56448 15567 11761 13113 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle 14661 68267 108682 20526 20528 76282 69354 55963 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 63959 434203 13178 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect 55951 100043349 216456 13806 56012 66171 18655 18770 16828 66945 67834 20514 18563 66925 20501 56451 209692 20917 14194 11429 13382 15926 235339 20526 11428 68263 14381 15929 170718 230163 18641 17449 18597 21881 67680 78920 66052 12974 14751 14661 18746 19895 15277 21351 110208 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway 11421 TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease 54342 15275 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect 18598 229699 55951 20511 74419 100043349 216456 13806 20525 18655 66945 67834 18563 56451 209692 14194 20917 11429 13382 235339 15926 68263 11428 170718 14381 17449 67680 56421 12974 14751 14661 18746 15277 19895 21351 110208 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease 54342 15275 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) 235293 18194 13121 98386 15490 13360 13595 74754 66234 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway 56717 26413 54721 20848 16451 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway 104158 12038 436059 18390 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism 69718 56208 71780 55980 225326 66461 242291 234729 18706 104015 18798 12462 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway 670717 19353 19765 18706 11783 12675 57257 11848 12371 110157 56044 13712 54601 15461 11651 18805 19730 12048 17127 17128 26395 12015 26417 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis 11607 13079 15497 14702 14682 13072 14688 13070 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency 14121 14381 66171 18641 21881 75456 11674 14751 72157 19895 71336 21351 66646 110208 232449 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis 21823 18948 13195 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway 13649 26357 18671 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria 14718 14629 12583 83429 27267 246221 16828 107869 14630 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway 16416 16399 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway 11421 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling 11651 19877 432530 20807 16438 381810 14702 14688 18795 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway 11668 13114 13088 13087 72303 11670 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) 14652 227289 20494 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling 16337 26413 16367 16334 20528 14784 20416 20662 26419 110157 15461 11651 26395 30955 104709 26396 56458 384783 18607 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency 18563 13382 235339 68263 17449 18597 110446 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 17436 76238 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 107045 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism 69718 327655 71780 55980 56409 27399 242291 104015 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid 17449 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism 56208 18802 55980 225326 234729 104015 75669 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway 16416 16399 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency 14629 14782 14854 68214 75475 16790 71522 14775 68252 14630 12369 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway 70839 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System 18749 13488 210044 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action 20608 12346 15466 11944 11945 20604 14459 12426 12671 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway 107141 13849 13114 13088 72303 13113 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway 12043 12566 12534 12447 13555 17873 12443 18538 12028 11783 12567 19645 12575 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway 109828 230558 12279 15139 14962 12266 12274 12258 11537 625018 12259 12260 12262 667277 317677 12263 17195 17175 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway 26441 56424 26442 22194 23997 24108 19185 22201 26445 26446 19172 19173 19175 19177 67089 26443 26444 19170 22190 19179 19181 19182 23996 19184 26440 19166 19167 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura 11677 19012 235582 14732 55979 14555 16956 15450 50784 14571 11670 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway 14784 26419 110157 26401 13712 15461 60595 16476 14714 18805 14715 26400 14672 17390 26395 224129 12322 12313 17387 14308 13869 16866 20779 11911 13653 12640 242274 12540 15200 26413 16438 18750 18795 18751 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism 17960 13077 13114 13087 72303 22436 13106 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary 234730 75454 22122 75540 331026 21991 14121 15275 230163 18641 11674 218138 11677 29858 18639 110119 20322 16548 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis 18746 15277 100043349 13806 20525 56421 14751 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway 20963 19353 17060 14784 17096 15985 109305 20416 26419 14281 26401 110157 13712 15461 16476 26395 19055 26417 19056 12229 12518 18021 73181 18018 18019 20662 19057 640703 22324 18750 18803 18751 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling 14745 11651 19877 432530 20807 16438 14702 14688 18795 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism 71911 15356 67041 110446 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 27053 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway 17523 13114 21973 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis 68671 18618 320951 99712 12660 13026 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism 56208 16329 71780 55980 228361 17330 56727 66461 18706 217837 234729 12462 75669 18799 104015 224020 228550 83493 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis 69719 21973 97165 434174 14939 13804 12367 13347 12369 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway 16416 16399 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA 18749 19088 14699 271639 18747 19085 19087 19084 14688 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 85305 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway 72157 19895 74419 71336 14121 21351 14381 66646 232449 56421 19139 14751 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome 110006 22239 15275 14751 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway 109828 230558 12279 15139 12266 12274 625018 12259 12260 12262 667277 317677 12263 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis 100043349 14377 12183 13806 21991 56012 20526 230163 319625 14751 18746 18648 18642 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism 20322 14121 15275 18640 11674 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway 16334 12286 20526 56808 12295 20927 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism 110006 22239 15275 14751 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism 226518 225994 12182 59027 67993 76952 11761 18605 18950 18115 67375 192185 78914 18113 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway 11421 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism 20322 15275 18640 14751 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL 56717 18671 14784 22059 20662 20850 16452 20517 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease 54342 15275 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism 107766 70560 56720 98256 71562 22375 21990 11298 70789 266645 13195 21743 13076 23923 15930 11669 12359 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation 66925 17449 67680 66052 12675 12974 56421 12475 117149 22034 17087 18033 18035 21898 13358 16151 17874 16150 19697 107476 104112 17436 66945 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis 18749 14699 12000 14701 14688 14309 210044 COAGULATION%SMPDB%SMP0000586 Coagulation 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation 60525 72535 11669 13106 68738 12359 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency 11677 19012 235582 14732 55979 14555 16956 15450 50784 14571 11670 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 353172 27050 27370 20115 319195 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia 11677 72157 74246 14430 226413 216558 12091 14387 11605 14377 15275 14595 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) 235293 18194 13121 98386 15490 13360 13595 74754 66234 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 107271 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency 11677 12408 19286 320415 14528 110391 20751 13361 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) 226518 59027 93759 12494 71361 18104 66454 74080 22059 192185 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer 55951 216456 20540 209837 56309 16828 104112 17436 269951 66945 55963 67834 20514 18563 14719 66925 20501 56451 209692 20917 14194 11429 13382 235339 68263 15929 170718 18597 67680 78920 66052 12974 14661 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis 19895 21991 66646 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle 56365 11933 100038824 11928 98660 232975 107723 11931 20495 11932 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway 100039707 270685 14287 52466 17769 69606 108156 667301 107747 14317 13361 17768 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 76282 55963 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway 11944 11945 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 20115 319195 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency 21823 18948 13195 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway 19229 12767 14677 14699 26413 110157 18033 15461 18035 12928 26395 26417 19303 14682 14083 18803 14688 12927 18705 20315 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway 11421 FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway 11607 100038824 11606 11421 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway 107141 17161 109731 18549 11933 20264 11928 98660 13113 56808 12295 56448 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) 14719 69719 97541 231327 216456 54342 14415 14630 14661 268860 67417 56174 212647 14629 14782 14583 14854 214579 227231 14645 76282 229363 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary 18642 14120 21991 15275 230163 11676 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway 243764 11933 11938 13077 13114 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia 18563 55951 224805 76282 11611 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling 19766 21353 12366 26397 12905 71609 22030 21926 26412 100040260 26399 12675 26419 26416 26401 26398 18033 16476 18035 16151 26400 16150 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation 16922 11671 26874 11666 26458 56794 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway 11651 104709 18750 18803 18795 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 52538 93747 231086 97212 11363 14081 57279 12894 12896 15107 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 327655 69718 16329 71780 55980 269180 76500 71207 228550 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis 18563 55951 100043349 14377 12183 13806 21991 56012 20526 14121 67863 230163 319625 14751 211347 72157 18648 18534 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway 18549 11933 20264 13087 11928 394433 13088 98660 394434 110834 56808 12295 14262 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy 12091 11605 14420 208449 22234 66190 20773 11883 50877 22239 70750 56632 20397 19012 56386 223753 433323 70059 53897 268656 238011 14466 171168 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 14317 11670 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 105148 27370 20115 319195 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle 14719 78830 17448 67863 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) 54369 320685 76952 69719 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 110074 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway 108645 74129 110695 232087 14711 20425 12116 192166 218865 108037 68682 100434 238505 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway 12263 109828 17195 230558 17175 12279 15139 12266 12274 625018 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis 107476 14104 CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway 104158 72269 72962 22171 434203 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 104458 319195 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism 268860 104776 11669 64705 99586 11754 103149 338403 14415 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway 17523 13114 21973 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria 18563 55951 68263 67863 17449 18597 104112 17436 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway 107141 18979 70839 13077 13114 13088 18671 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway 16334 12286 20526 56808 12295 20927 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency 14719 69719 97541 231327 216456 54342 14415 14630 14661 268860 67417 56174 212647 14629 14782 14583 14854 214579 227231 14645 76282 229363 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 11549 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) 52538 93747 26922 231086 97212 19063 15108 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency 54369 320685 76952 69719 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 110074 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells 14125 16822 16163 16191 16189 16653 20963 19353 228026 18783 14784 18706 17096 18176 16797 12981 14127 57257 26419 14126 26416 110157 26398 15461 11651 18708 26400 14360 26395 26396 26397 26413 12229 21926 26399 20662 14389 18750 18803 16331 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production 20608 12346 15466 11944 11945 20604 14459 12426 12671 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 216456 269951 66945 67834 18563 66925 56451 209692 20917 14194 11429 13382 15926 235339 11428 68263 15929 170718 18597 67680 78920 66052 12974 14661 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway 74419 14121 14381 66171 56421 14751 110639 72157 19895 71336 21351 66646 232449 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation 12912 18033 16151 26413 16150 26417 18750 18127 18795 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway 13649 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form 110948 100705 26363 69019 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway 11944 11945 NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 27053 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism 211488 246277 12583 71522 14415 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway 238871 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway 13649 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 63959 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency 19895 71336 14121 21351 14381 18641 21881 11674 19139 14751 QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway 70839 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation 15469 27221 18049 15417 12226 14164 12227 12443 22059 19645 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway 16334 12286 20526 56808 12295 20927 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium 26946 60596 16536 110862 271639 54195 18127 234889 19091 19092 22065 22066 63873 60613 226922 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway 107141 13077 13114 56448 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway 20887 18102 50773 26357 20519 212862 18671 17250 66588 76408 20517 12780 18655 68671 20518 239273 13178 13026 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway 107141 20538 13114 56448 15567 18671 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) 72157 67883 74246 14430 216558 22235 103988 14635 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway 72303 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway 11944 11945 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency 110006 22239 15275 14751 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis 14719 69719 97541 231327 216456 54342 14415 14630 14661 268860 67417 56174 212647 14629 14782 14583 14854 214579 227231 14645 76282 229363 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification 18950 11832 64008 14873 57344 20528 20525 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 107271 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation 18033 16438 15465 14702 14682 14688 18751 18795 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism 327655 16329 71780 55980 234515 17330 56409 27399 217837 104015 228550 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20226 20115 319195 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling 11651 19877 432530 20807 16438 53978 14702 14688 18795 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease 18663 68401 12183 13806 21991 15275 230163 319625 56421 14751 14447 18746 239606 18648 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell 20650 12286 20526 56808 14526 20649 12295 20648 20927 20271 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria 234730 75454 22122 75540 331026 21991 14121 15275 230163 18641 11674 218138 11677 29858 18639 110119 20322 16548 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 18749 14699 19222 14688 17897 107589 210044 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 26409 12675 26419 26416 12475 26401 26398 117149 22034 17087 18033 18035 21898 16151 17874 16150 19697 54473 170743 16179 66513 142980 24088 68652 26940 81897 53791 21899 66724 21897 170744 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis 66812 75735 22361 71743 18605 106564 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway 14121 14381 66171 18641 21881 75456 11674 14751 72157 19895 71336 21351 66646 110208 232449 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway 100038824 11606 11421 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 109905 11909 19094 26407 18034 54126 109880 11540 18479 223864 56513 18706 76089 18762 12675 26419 26401 13712 18033 15461 11651 16476 18035 26400 16150 26396 18607 18749 12912 14699 26413 20111 26399 12015 14688 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor 16438 14682 18750 18795 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary 100039707 270685 14287 52466 17769 69606 108156 667301 107747 14317 13361 17768 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism 13382 110446 12039 68738 12040 268860 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria 52538 93747 26922 231086 97212 19063 15108 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 110960 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect 55951 100043349 13806 56012 20512 18655 18770 66945 67834 66925 20501 56451 209692 14194 11429 13382 15926 235339 11428 68263 14381 170718 18641 17449 21881 67680 78920 66052 12974 14751 14661 18746 14660 19895 15277 21351 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis 11677 12408 19286 320415 14528 110391 20751 13361 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism 72157 67883 74246 14430 216558 22235 103988 14635 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine 67248 100040331 432502 667279 668144 100043755 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 234734 100038875 19921 100038991 100043876 267019 100043000 100043423 100042986 16785 100040298 20044 20088 100042740 667618 56040 666669 57294 100040970 100043391 20085 20084 19899 100039924 67891 100042823 66480 100039656 67097 672959 19934 666586 66481 676253 67025 670211 19941 100043527 14694 666487 20055 20054 67427 27207 68193 67186 19989 19951 76808 75617 20103 20102 20068 22121 65019 26961 27050 27370 20115 319195 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway 12780 13114 18671 17250 545486 19765 22143 22059 224814 76408 12575 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway 11421 CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 11549 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway 100038824 11606 11421 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism 69718 102954 16332 277360 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis 12850 71883 217707 52064 230027 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) 18563 66925 56451 55951 209692 20917 14194 11429 13382 235339 68263 15929 170718 17449 18597 67680 78920 66052 12974 66945 67834 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 14317 11670 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway 107141 13114 238871 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 52538 93747 231086 97212 117147 57279 11364 15107 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism 20887 211389 23972 23827 58250 54200 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism 15483 71853 69191 67838 12304 78925 208665 394436 15487 83702 19035 64136 13075 12282 67397 14828 110115 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway 107141 11668 14863 13114 13088 13087 72303 11670 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate 55951 269951 66945 112407 67834 112406 18563 66925 27376 56451 209692 20917 14194 11429 13382 15926 235339 11428 68263 15929 170718 18597 67680 78920 66052 12974 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway 16542 22339 14254 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway 22236 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 71773 231396 18390 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway 18549 11933 20264 13077 13114 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis 19210 68671 320951 99712 12660 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine 67248 107271 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis 18663 68401 12183 13806 21991 15275 230163 319625 56421 14751 14447 18746 239606 18648 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism 72469 56208 18711 16329 71780 55980 228361 225326 56727 17330 269180 66461 18706 217837 234729 75669 75678 69718 224020 103199 228550 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis 71519 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway 22236 74147 231086 97212 13088 13087 66885 117147 56357 15108 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 226414 27050 27370 20115 319195 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance 11933 11928 226413 98660 20526 232975 20537 11931 11932 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway 100038824 11606 11421 METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 20650 20649 20648 20271 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway 11668 13114 13088 56448 394434 224814 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway 13649 13869 13867 18750 11491 19164 100042150 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway 76932 329251 18595 12568 12631 11461 18479 12445 19353 17906 12443 19765 16885 18538 12331 83767 57257 107589 12575 26401 18805 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism 13142 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation 12411 107869 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis 14377 100043349 12183 13806 20526 56012 319625 11674 14751 18655 18648 18642 15277 18770 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) 12091 11605 14420 208449 22234 66190 20773 11883 50877 22239 70750 56632 20397 19012 56386 223753 433323 70059 53897 268656 238011 14466 171168 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 22239 15275 14751 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway 55984 14082 26409 12675 26401 22034 18033 18035 21898 16151 17874 16150 19697 22190 19766 71609 21926 53859 16177 21937 21938 16179 17979 66513 16175 207565 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism 11461 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway 107141 18549 11933 20264 13114 11928 13088 98660 13113 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 72303 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect 55951 100043349 13806 56012 66171 18655 67834 20514 18563 20501 56451 20917 14194 18293 11429 13382 27402 15926 20526 11428 68263 170718 15929 14381 17449 18641 230163 18597 78920 67680 21881 66052 12974 14751 14661 18746 19895 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism 56473 76267 83603 68801 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency 14629 14782 14854 68214 75475 16790 71522 14775 68252 14630 12369 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease 12091 11605 14420 208449 22234 66190 20773 11883 50877 22239 70750 56632 20397 19012 56386 223753 433323 70059 53897 268656 238011 14466 171168 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism 20860 78925 208665 15497 15487 15485 13075 54200 100559 13074 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism 110695 232087 18618 12116 269378 218865 108645 238505 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency 110948 100705 26363 69019 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway 100038824 11606 11421 ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine 67248 27267 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 17869 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency 18563 55951 224805 76282 11611 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway 13649 FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway 104158 12780 13114 436059 26357 18671 100042069 394434 72303 23917 28253 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway 18549 11933 20264 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 11670 CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway 107141 18979 70839 13077 13114 13088 18671 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis 13057 214593 99439 224480 21819 114479 22018 13058 50490 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation 54128 76355 234730 75454 320844 22122 75540 21991 14121 18641 230163 11677 18639 110119 20322 16548 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 109905 11909 19094 26407 18034 11541 54126 109880 18479 223864 56513 18706 76089 18762 12675 26419 26401 13712 18033 15461 11651 16476 18035 26400 16150 26396 210044 18607 18749 12912 14699 26413 20111 26399 12015 14688 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome 14377 100043349 12183 13806 20526 56012 319625 11674 14751 18655 18648 18642 15277 18770 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell 12286 20604 20526 56808 12295 20927 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling 56717 16337 64930 16367 22084 16334 13685 13684 11651 30955 104709 20539 384783 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency 11677 12408 19286 320415 14528 110391 20751 13361 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency 71911 15356 67041 110446 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling 21898 15251 16176 64384 320452 216799 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway 13114 394434 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency 18563 13382 235339 68263 17449 18597 110446 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 17436 76238 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway 11421 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway 18549 11933 20264 11928 98660 18387 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 18749 19045 12912 14699 14688 15562 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism 71853 69191 12846 67838 12304 394436 19035 15485 64136 12282 13076 67397 14828 20860 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway 13649 NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway 13649 18747 14784 26419 26416 26401 110157 26405 13712 60595 15461 16476 18805 14714 14715 14672 432530 26400 12288 17390 26395 12322 17387 14308 16866 56808 20779 12295 11911 13653 12640 242274 15200 12289 54652 12292 26397 26413 20662 16438 18750 18751 18795 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway 22171 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism 56208 71780 228361 55980 225326 17330 56727 269180 66461 170835 234729 217837 75669 12462 75678 23827 69718 18799 228550 83493 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 11409 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 26409 12675 26419 26416 14281 12475 26401 26398 117149 22034 19013 13712 17087 18033 19106 16476 18035 21898 16151 17874 16150 19697 26397 26399 54473 170743 16179 66513 142980 24088 68652 26940 81897 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis 66461 14732 74451 14555 110911 66586 52123 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway 19353 16818 14784 18706 16797 20416 26419 14281 26401 110157 26398 13712 18033 15461 16476 18035 12501 18708 22637 14360 26395 19055 19697 26417 320139 19419 22190 12502 12503 19056 12500 18021 73181 18018 18019 20662 19057 640703 22324 30955 18750 18803 18751 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway 269346 22017 15452 11534 231327 11761 19353 23917 22436 27416 239273 114304 63959 229363 13340 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway 12288 56808 12295 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 54369 320685 76952 69719 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 110074 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway 18749 18125 13385 11669 16438 22436 19055 14811 14810 18750 640703 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect 55951 229699 74419 100043349 13806 56012 20525 66171 18655 66945 67834 66925 18563 56451 209692 14194 20917 13382 15926 235339 68263 11428 14381 15275 17449 18597 67680 78920 66052 56421 12974 14751 14661 18746 14660 19895 21351 110208 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia 57028 216134 11647 103711 11761 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency 14719 69719 97541 231327 216456 54342 14415 14630 14661 268860 67417 56174 212647 14629 14782 14583 14854 214579 227231 14645 76282 229363 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome 13649 56208 52858 18711 18704 13866 18720 228361 225326 234515 18707 234729 75669 18708 19211 64436 104015 18718 224020 103199 18795 16331 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway 107141 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic 14718 14629 12583 83429 27267 246221 16828 107869 14630 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) 20186 239273 28250 227289 20494 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids 16922 26874 14081 57279 11666 11669 12908 56794 12896 72129 56273 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 269614 55951 17448 100043349 14377 13806 14121 56012 21991 67863 319625 11674 14751 15277 18534 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome 14430 216558 76025 14377 66588 16770 22232 20525 14595 18103 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway 22171 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 20266 11931 15550 11932 11549 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway 13114 13088 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 72303 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 18563 13382 235339 68263 17449 18597 110446 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 17436 76238 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 12040 268860 93747 227095 66904 110821 11364 13171 104776 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism 12091 11605 14420 208449 22234 66190 20773 11883 50877 22239 70750 56632 20397 19012 56386 223753 433323 70059 53897 268656 238011 14466 171168 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) 15492 15484 15483 13079 208665 15497 83702 13072 110115 13070 13074 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 104174 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis 18642 15277 100043349 14377 13806 18770 21991 56012 319625 11674 14751 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production 18749 14699 18976 17200 14688 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 22239 15275 14751 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway 11668 13114 13088 13087 72303 11670 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway 11944 11945 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway 18749 18125 13385 12313 19055 14811 14810 18750 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway 15519 11863 11622 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway 20807 20848 14784 100039026 20416 13645 20850 26419 218397 16452 14281 110157 26401 13712 15461 16476 26400 26395 26417 13869 18750 18803 18751 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling 11651 19877 432530 20807 14702 67168 14688 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation 234730 75454 22122 75540 331026 21991 14121 15275 230163 18641 11674 218138 11677 29858 18639 110119 20322 16548 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease 110006 22239 15275 14751 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease 18642 15277 100043349 14377 13806 18770 21991 56012 319625 11674 14751 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 14661 109093 212647 227231 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency 14629 14782 14854 68214 75475 16790 71522 14775 68252 14630 12369 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway 107141 13077 13114 56448 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway 13113 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation 18642 14120 21991 15275 230163 11676 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 15115 27050 27370 20115 319195 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency 14121 14381 66171 18641 21881 75456 11674 14751 72157 19895 71336 21351 66646 110208 232449 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway 20538 56448 15567 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 11931 11932 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin 18749 19045 12912 14699 16866 16867 14688 12640 210044 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation 11933 11928 226413 98660 20526 232975 20537 11931 11932 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency 18563 55951 17448 14377 75735 100043349 12183 14385 13806 21991 20526 14121 56012 67863 319625 11674 14751 72157 18648 15277 18534 16828 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism 11677 19012 235582 14732 55979 14555 16956 15450 50784 14571 11670 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation 18746 100043349 21991 56421 14751 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway 19895 71336 14121 21351 14381 18641 21881 11674 19139 14751 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency 216558 74185 69983 232714 232493 14751 70974 72157 110006 77559 100043686 15277 22235 103988 110095 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis 13350 14732 55979 14555 14245 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency 12411 107869 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway 11944 11945 VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway 11607 100038824 11606 11421 14702 14682 14688 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia 268860 104776 11669 64705 99586 11754 103149 338403 14415 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 70974 110006 71773 100043686 77559 216558 15277 22235 103988 110095 14751 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation 209692 13382 266645 78920 237320 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 22375 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20115 319195 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism 327655 16329 71780 55980 234515 17330 56409 269180 27399 217837 75678 69718 228550 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 12842 110135 99571 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 15107 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action 18033 16438 15465 14702 14682 14688 18751 18795 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria 13382 110446 12039 68738 12040 268860 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency 20860 78925 208665 15497 15487 15485 13075 54200 100559 13074 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC 71803 269614 74551 69719 55951 17448 68401 12183 13806 21991 15275 230163 319625 14751 14447 239606 18648 14120 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule 11933 11928 98660 11827 56365 100038824 11828 20541 11944 11945 232975 11931 194352 11932 20497 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 76282 55963 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway 11421 PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 20648 11931 11932 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells 14125 16163 16189 20963 16653 19353 17060 16818 14784 18176 17096 16797 12981 26419 14126 110157 15461 11651 18708 26400 14360 26395 26396 26413 21926 14389 18750 18803 16331 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation 84112 12912 19094 26413 18127 12675 19224 18033 16151 16150 26417 18750 18795 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway 12362 670717 18646 330914 11855 11545 11857 12370 12367 11783 12371 16476 14939 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria 18642 14120 21991 15275 230163 11676 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria 14629 14782 14854 68214 75475 16790 71522 14775 68252 14630 12369 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 71519 14775 208285 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine 67248 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 100042670 67281 629957 100039316 667739 225058 76846 100038875 19921 100038991 100043876 100043000 267019 100043423 100042986 100043295 16785 20044 100040298 625646 622534 100042740 667618 666669 56040 57294 100040021 100040970 100043391 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 70223 65019 27050 27370 20115 319195 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome 18663 68401 12183 13806 21991 15275 230163 319625 56421 14751 14447 18746 239606 18648 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine 18749 19045 12912 14699 15466 14688 210044 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 73166 20652 66234 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling 11651 432530 65086 16438 14702 14688 18795 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate 18563 66925 56451 55951 209692 20917 14194 11429 216456 13382 15926 235339 11428 68263 15929 170718 18597 67680 78920 66052 12974 269951 66945 67834 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors 11835 22337 14815 19401 229615 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis 102247 70568 74451 56305 12651 13001 116939 237928 56018 12891 100039026 67800 75320 66586 212862 66461 85031 23945 225845 27388 266692 74182 68682 97212 77582 106861 14245 215456 99010 237625 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling 13649 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition 12442 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 16475 104318 12234 16328 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix 18815 50817 17228 13035 12822 16621 12367 23948 58223 11491 73647 72902 11504 30800 17381 71753 21892 12816 12339 83995 22072 23830 12153 17393 64706 12821 17395 12819 17384 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression 209357 21664 74322 74016 103551 75316 228829 434178 23989 217031 237758 12568 13872 208146 54194 67279 14056 319149 245688 66467 319183 17283 319182 74522 15161 243834 50724 233060 60406 11520 57230 264064 56406 20249 68801 216154 170826 21429 17749 100043714 208043 625328 433759 234959 269003 14311 69556 18432 23894 51813 78303 319181 11770 67800 15270 69612 101739 70208 11569 234366 23945 75339 14245 16475 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides 20202 11927 66557 57757 629114 12652 18843 11870 13035 19152 72621 19695 54159 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis 13389 57296 56184 69077 66997 12387 26443 26444 19170 13838 19181 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism 26363 330064 18563 100705 72621 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport 68682 75750 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements 109075 26416 70640 66583 11651 22695 72544 26443 26444 19170 19181 57296 69077 66997 50911 69583 69639 18458 72662 227715 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state 245866 81896 18749 56438 26443 19084 26444 106633 19170 19087 16396 19181 319757 70300 57296 69077 66997 12234 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 246179 24060 243853 67843 75847 228366 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 319149 245688 78303 319181 319183 15270 319182 625328 433759 234366 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs 56438 26443 26444 19170 19181 57296 69077 66997 114715 114716 320484 69601 18015 101809 54153 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation 11537 14962 HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle 17749 100043714 23894 101739 319944 103468 209357 19069 98053 70699 67710 234865 108138 18571 20833 73711 66464 68776 99730 13872 22088 67123 208092 100088 66700 445007 226182 66467 24074 18107 13716 110379 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 29873 15212 109685 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes 230073 74153 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling 11772 11771 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade 226849 212398 225849 26931 21770 26932 12387 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib 12539 59079 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 234847 18673 73078 12034 216001 215999 381038 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development 12387 16449 15378 14573 15396 20472 14048 15431 15412 15403 15904 16869 18510 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK 17242 18708 433759 11682 327826 16367 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat 209357 23894 98053 67710 66467 13716 17749 100043714 20833 13872 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs 233833 12552 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF 14312 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins 72303 56448 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants 12539 59079 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 233107 106931 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX 233833 17222 68612 68999 12387 56371 668450 66156 12578 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection 27370 19247 56217 629957 11651 100039316 233870 230398 16451 170743 233405 66481 57437 77573 225058 192656 107895 54721 71951 20442 20970 20390 20443 75669 66589 80743 20440 14735 56480 20447 105722 11652 14734 384091 103468 666609 19069 16171 67075 70699 257630 107607 234865 103534 108687 269181 27207 71732 69035 208092 66700 445007 110379 230073 16179 633683 66603 20014 66383 103963 68652 53975 14376 68292 15007 23797 69038 208884 20815 13135 75617 57294 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome 319944 209357 98053 67710 17749 100043714 20833 66464 68776 99730 13872 23894 226182 66467 24074 13716 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels 110891 20541 67972 11941 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors 11444 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 22142 14675 13001 24128 16553 55946 14688 22151 100039026 67466 238463 14704 14696 12447 14693 30838 20698 12468 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins 434178 625328 237758 433759 319149 245688 78303 319181 319183 15270 319182 243834 234366 233060 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing 16476 233833 13710 21781 13557 211586 333639 18131 54613 625328 319149 78303 20443 319181 319183 15270 319182 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 11651 71514 14815 13819 11848 13649 13448 12928 330662 106766 20459 12402 12447 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism 18606 106564 269614 14104 330064 72621 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion 74205 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript 103468 19069 445007 70699 64340 234865 233073 53817 110379 225160 386612 73666 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 64177 171382 22068 68667 63873 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation 19766 17087 21898 22030 14102 21933 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation 57296 69077 66997 68652 100041766 66589 216150 26443 26444 19170 12234 19181 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 12064 12568 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization 13649 20459 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 103468 19069 445007 70699 234865 110379 103988 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 66634 12544 69270 272551 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 21812 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation 109905 26413 26395 26396 327826 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling 19247 327826 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly 238055 17777 11812 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase 17222 68612 68999 56371 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 12234 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism 11651 18749 19084 19087 103468 19069 70699 234865 445007 18107 110379 29873 15212 109685 21770 18708 72303 56448 633683 75617 57294 27370 629957 100039316 66481 225058 71951 20442 20970 20443 75669 14735 14734 27207 14675 14688 14704 14696 14693 20698 54613 18606 106564 269614 14104 74205 103988 109905 238055 216820 270198 20860 18798 75597 18799 56453 15356 107146 241447 15108 114875 217666 234724 330260 246221 11886 269823 11992 18984 67105 18639 18640 170768 67895 20494 14348 269642 15366 15118 109900 17159 56421 11761 234779 20544 17161 235293 231327 15483 232087 19025 18115 435528 29859 15488 320207 66065 54219 26940 11484 631304 56185 68465 635960 56615 18534 66447 67044 20509 217119 54338 20751 20522 67073 53625 67426 68421 11806 11807 11808 72157 195646 104015 22333 52892 66394 23831 232449 11486 52538 11813 11814 11816 230753 54369 77697 16922 17001 21743 69065 54325 78923 11677 12040 68393 72482 67993 14544 239559 68523 100900 66646 66443 20133 67891 76893 226518 74129 26876 17113 666669 71562 106529 240752 17436 80908 243537 66359 69051 17449 52469 17448 56050 432502 108099 14120 70484 19989 30955 19899 269615 19934 56473 216134 319625 11847 13479 68365 73724 71773 13123 104112 56398 11428 666899 12041 22239 75475 66112 11551 66052 109674 11717 67680 76500 68680 100042986 22436 54371 625646 100042740 100042314 80914 73046 67003 30963 66694 22275 78894 66089 67248 77559 66690 26922 69702 13521 230779 56386 14593 223753 66071 56360 16770 272428 227683 18104 56705 21990 83398 219135 269378 50786 67464 108755 13370 14751 71365 227095 74134 93683 50493 171281 74156 22171 80509 20768 170749 432628 14871 50877 59045 54384 94215 545260 74011 380840 240444 98386 13190 271424 13722 233801 102954 238276 544717 217837 320404 14711 109672 21881 14660 65967 233081 67870 319655 67092 230125 433323 574418 72090 102570 75420 14645 12971 76263 14678 170439 227102 18247 68198 12846 14528 552899 67674 66416 76267 70750 269400 18102 100042503 56520 230075 16500 14381 16329 67264 109791 14377 74637 26938 13122 17117 240753 101490 14387 68631 225887 12861 170460 14385 16334 269180 226646 16330 624814 18293 12862 211006 14598 75612 66190 27376 271970 100041785 67469 13072 110115 192289 19299 66194 98314 105193 170718 26459 15926 56727 55990 17705 228775 213012 76205 74776 218865 110078 67824 110095 19309 269951 64385 238076 17764 19215 12894 71761 14421 545975 209176 243382 17711 229709 14422 57344 18010 12908 14276 15442 216456 15526 26379 108156 21452 12716 17721 17722 66999 100043349 19047 17772 17719 53412 19141 20597 71803 26943 12715 93898 12583 28253 20810 66821 238505 75894 26425 26457 13806 107239 52710 380975 77219 26378 233552 66681 67054 78797 110695 80982 100043508 107747 56794 19156 19249 66091 14200 69568 66272 12408 13807 108652 12411 75986 217707 68015 66414 100041835 12346 19063 100038991 67388 217214 23827 105148 70456 73748 12349 12350 67442 12353 12354 76654 11863 74442 66569 52466 18979 15288 13849 16204 68332 16592 14077 436059 22236 19193 21351 117150 217593 26878 215015 11864 20524 22337 102247 70568 74451 56305 12651 13001 116939 237928 56018 12891 100039026 67800 75320 66586 212862 66461 85031 23945 225845 27388 266692 74182 68682 97212 77582 106861 14245 215456 99010 237625 22072 23989 67279 74522 11520 264064 56406 20249 68801 216154 170826 234959 14311 51813 11770 70208 72621 26443 26444 19170 19181 57296 69077 66997 26363 330064 18563 100705 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds 107146 71773 57344 23827 14871 75475 94215 69065 233801 14598 100042314 22236 232087 238505 319655 435528 29859 76263 213012 56615 272428 66447 12846 552899 67674 70484 269378 20860 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis 21990 INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes 18439 12362 66824 67955 383619 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model 74011 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects 17222 68612 68999 56371 668450 66156 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation 67895 110960 13722 105148 22321 353172 66590 107271 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 109905 15234 67299 14388 12928 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 11839 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA 19247 208154 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 225058 633683 432502 100042986 67160 19989 625646 100042740 19899 19934 75617 57294 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation 14178 67112 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border 18999 12387 21415 22771 17863 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) 11651 23797 22084 11652 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism 27370 11847 107146 15108 629957 100039316 100038991 234724 217214 246221 666899 105148 66481 12041 11992 73748 225058 269642 100042986 18293 109900 211006 625646 100042740 27376 19193 192289 217593 67248 66194 27207 230779 11484 66071 218865 18104 67824 21990 269378 13370 71761 227095 209176 243382 50493 12908 20768 216456 12716 21743 13190 13722 12040 26943 12715 14711 12583 20810 14660 65967 67891 238505 68682 67870 74129 67092 107239 666669 574418 71562 75420 26443 14645 26444 12971 243537 19170 69051 110695 633683 19181 57296 18247 69077 432502 66997 19989 19899 19934 12411 75617 75986 57294 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production 228421 14460 26934 67414 16552 16580 230398 73804 11640 78287 18749 22761 22762 19084 625328 16562 433759 15353 19087 330662 12340 170731 16565 75050 17133 99982 217837 12568 67299 319149 17863 16594 16923 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion 81600 109791 100043686 67717 69656 14915 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 67204 26905 13667 209354 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation 233405 108664 12721 19349 18126 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling 21351 68981 20656 53379 12346 16162 16161 16160 16159 16451 12631 18569 15526 12340 54721 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 12013 56438 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 76257 26570 50934 20540 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes 264064 56406 20249 68801 216154 170826 208043 625328 234959 14311 69556 51813 78303 319181 11770 67800 15270 69612 101739 70208 23945 21664 74322 14245 228829 23989 217031 12568 208146 54194 67279 319149 319183 17283 319182 15161 16475 11520 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors 14276 108156 21452 77697 18606 106564 269614 14104 52466 22072 11761 67993 109672 238505 226518 230125 52710 54219 102570 72621 107747 20509 26363 54338 330064 18563 20522 100705 68421 216134 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated 26413 21770 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response 26416 17886 11491 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 56187 14381 18854 26416 12021 76367 69260 11651 227743 69131 23988 66813 59092 67338 12227 66262 225655 225182 12861 104625 208836 68240 19891 58184 14088 83409 17246 12862 52679 15257 18983 18148 64058 56716 252870 100041785 69181 29813 319944 22427 19718 98053 67710 20833 66464 68776 99730 226182 24074 13716 26931 216456 13001 100039026 233833 380975 219103 108099 23797 11652 117150 209357 228829 12362 12568 13872 245688 66467 12447 14751 22084 16476 50493 21781 211586 17749 100043714 433759 23894 234366 14660 14102 21933 69263 57748 108961 66494 57913 18996 12366 26909 18538 12427 70088 241113 106344 72151 12905 219022 19367 53325 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism 67092 12715 12716 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes 66262 225876 100683 216825 18602 27878 20174 228829 21427 56505 109115 217031 52690 66464 244694 71371 78656 208146 64707 104263 74026 14056 214572 319149 277250 245688 72341 20591 319183 66923 107392 319182 242726 218214 15161 193796 225888 50724 73251 75605 60406 230233 208043 15353 433759 269003 99982 78303 319181 15270 69612 11569 234366 70088 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 17222 68612 68999 668450 66156 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules 107566 71279 24060 225579 243328 26457 330064 70484 72621 108652 269346 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle 74194 50875 53382 232339 93840 109620 20355 233877 380664 16709 216197 227937 233489 21927 19249 18708 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants 16590 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 105243 110895 226999 20544 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 26416 23988 624814 103468 19299 234865 445007 110379 226849 225849 26931 21770 74194 26932 50875 12539 53382 11835 59079 232339 93840 109620 20355 233877 380664 16709 216197 16449 227937 233489 21927 19047 216963 386750 239027 56419 232987 212285 18708 70497 12261 327826 224480 73296 18016 238505 320795 109333 320271 208846 330319 67784 13058 13057 14570 20740 11854 18751 17920 244418 270163 216965 14467 66871 213498 56455 195727 19249 66977 13427 14083 207212 442801 18844 13424 226751 19354 329165 13726 223870 57294 102920 12229 214804 110279 11464 14026 68097 75409 269682 105855 381318 84004 223254 27984 242687 12988 11671 66087 18221 404710 104445 22284 23912 75669 19418 109711 68089 26403 226747 66713 74117 14269 108000 277360 241275 245880 76117 263803 54004 12615 66570 56324 20401 22376 59069 13830 66898 69668 192176 71544 544963 21763 67299 56382 319149 625534 11352 94221 319183 66468 17283 213783 319182 77579 14270 106504 12447 117600 94190 54411 225358 16594 12468 219140 228421 26934 67414 73804 11848 625328 330662 170731 98386 99982 78303 319181 15270 53817 19349 20202 12631 12387 17886 26413 DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells 16163 16476 17132 241915 53314 16162 20230 50794 333639 12151 15184 22632 21926 12418 433759 245688 17283 234366 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration 11428 15926 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine 14583 19703 245847 56174 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling 11797 19766 106025 21937 11796 22030 21926 56480 76580 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex 100683 56505 12387 625328 433759 319149 12006 78303 319181 319183 17283 15270 319182 21415 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins 11831 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome 57296 69077 66997 18749 56438 26443 26444 19170 12234 19181 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 17087 21898 56480 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi 20443 17309 103534 269181 20440 56386 107895 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation 16476 26416 21770 107607 16179 192656 26413 26395 68652 66589 26410 17260 12234 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway 14381 243963 26416 22648 319974 235682 11651 14377 72720 69020 11604 22658 20371 72154 56438 213011 68527 17433 18741 16396 12861 56353 50496 77827 16334 22757 193452 80902 212712 269704 17702 12862 16825 242109 12981 22690 56275 16880 244556 100041785 11906 619310 319944 72180 98053 67710 20833 66464 68776 99730 226182 24074 13716 26931 216456 26379 16449 15378 233833 14312 233107 106931 17222 68612 380975 68999 56371 668450 66156 12578 16179 23797 19247 11863 11652 117150 11864 12362 21415 12447 17863 22084 16476 14460 21781 211586 333639 18131 22761 20656 14102 21933 12064 103988 69263 57748 108961 26413 66494 57913 18996 12366 26909 18538 12427 70088 241113 106344 72151 12905 219022 19367 53325 56187 18854 12021 76367 69260 227743 69131 23988 66813 59092 67338 12227 66262 225655 225182 104625 208836 68240 19891 58184 14088 83409 17246 52679 15257 18983 18148 64058 56716 252870 69181 29813 22427 19718 18534 66923 75605 11835 22337 14815 19401 11816 13001 16590 100039026 13649 18751 219103 108099 22284 209357 228829 434178 23989 237758 12568 13872 67279 14056 319149 245688 66467 319183 17283 319182 243834 14751 233060 264064 50493 17132 241915 216154 80509 170826 12151 15184 17749 22632 100043714 208043 12418 625328 433759 234959 23894 98386 51813 78303 319181 15270 17260 56461 70208 19293 70472 234366 69228 13345 17865 14660 241196 239652 192292 235028 94223 22709 109648 78251 21388 675812 18091 12387 29808 26443 21423 26444 12326 19170 12322 12323 19181 108058 12325 57296 17128 12477 69077 68744 66997 22693 21679 21678 12571 16183 272347 434377 26380 619331 21677 12579 244216 COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis 66414 67264 66690 69702 26940 15526 225887 17721 17722 68198 226646 624814 17719 66091 66416 108755 100042503 75597 100900 230075 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 382056 21425 12952 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion 15108 66132 68626 52575 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway 110135 14161 19152 58992 16621 109821 20720 14058 14061 14071 99571 71951 20970 20597 14735 105722 14734 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling 74011 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle 17749 100043714 23894 319944 103468 209357 19069 98053 70699 67710 234865 18571 20833 73711 66464 68776 99730 13872 22088 67123 208092 100088 66700 445007 226182 66467 24074 18107 13716 110379 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins 229615 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 109674 11717 75894 11486 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase 18749 19084 19087 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins 21826 140474 11504 66548 330267 207596 224697 223838 18131 20356 17829 18636 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication 27370 629957 100039316 100038991 17749 100043714 666899 66481 225058 100042986 625646 100042740 103468 67891 19069 98053 67248 70699 67710 234865 666669 27207 633683 445007 432502 19989 110379 19899 19934 75617 57294 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures 22427 12021 26909 269400 233826 71711 268465 225182 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 216227 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action 667370 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) 208092 66700 56324 73711 22088 67123 28084 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport 105722 13830 67972 11941 54411 27060 140494 20278 117160 170759 66144 170755 67331 252972 241118 20277 76295 242341 26373 26372 12728 50771 12727 12725 12724 97086 12723 11928 23844 192113 233979 11931 11933 171382 108664 140475 22068 11964 68667 11944 63873 11945 64177 14605 27219 11980 72621 12322 12323 108058 12325 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 11848 21812 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection 13479 26416 229709 12502 14687 58861 18749 19084 19087 17886 11491 14678 14688 14598 14704 14696 234779 14693 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function 12057 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 12402 26413 19247 14388 18708 327826 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 16476 26416 17087 21898 21770 22030 107607 71966 17874 170743 26940 69721 59025 67245 16179 192656 26413 26395 68652 66589 26410 17260 12234 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation 67112 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 19047 14245 11770 215456 67800 68393 16204 18749 16592 14077 23945 67469 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism 14645 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism 78894 15356 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs 544963 404710 17283 12387 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste 20278 20277 546729 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation 20443 103534 269181 20440 56386 107895 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly 12442 103468 19069 445007 70699 234865 110379 217718 59126 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A 11651 23797 11652 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry 71951 20970 14735 14734 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 26413 11651 11839 14083 23797 13649 11652 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism 93683 195646 71951 20970 83398 70484 15442 50786 14735 14734 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis 21987 29816 233489 252903 11774 232946 14319 20661 14533 117197 245638 109689 72685 19345 THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis 13370 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 20390 20387 12982 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 104318 51885 233276 16328 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling 12229 11651 14688 320207 14704 23797 30955 14696 11848 14693 11652 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling 19116 384783 26413 11491 16367 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis 227683 67426 71365 217707 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling 19056 14686 22419 225600 106042 14366 93840 22418 14368 11848 14369 18587 233833 208846 12387 26443 18751 26444 12322 19170 19181 57296 69077 66997 14688 14704 14696 21415 19354 14693 11772 11771 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation 17920 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) 16162 21926 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease 243382 12040 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants 11682 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response 228829 59092 26443 26374 26444 19170 19181 57296 69077 66997 17246 12427 12447 29813 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport 66061 56455 68097 245866 81896 106633 76411 12589 264134 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants 226849 225849 26931 21770 26932 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha 264064 50493 56406 216154 80509 170826 13122 26379 230753 234959 66999 11863 51813 70208 26457 11864 23989 17436 228775 67279 14200 76267 17764 12894 11806 11807 11520 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants 11682 ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets 26413 26416 21770 17260 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions 23792 54376 11488 246316 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism 26363 18563 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation 56438 16396 212919 22210 244421 66589 54484 76608 72194 15204 56515 22209 140629 22195 57751 74132 207304 231670 226541 104184 672511 69754 77113 70294 67615 68729 100041484 207952 66743 231672 56228 101358 321006 68098 14794 214931 217217 117589 74646 233902 231380 83962 20821 74153 30838 76580 17222 100041766 68612 216150 68999 56371 668450 26443 26444 66156 19170 19181 57296 69077 66997 12234 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors 13492 13491 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin 17161 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 24128 16553 55946 12447 30838 20698 12468 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion 14688 14704 14696 14693 11551 14678 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 16476 99412 19766 20656 54722 22030 625328 12568 14056 319149 245688 78303 319181 319183 15270 319182 12261 18969 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism 13479 171281 20249 73724 74156 68801 19063 330260 104112 12908 52538 17117 269823 16922 17001 54325 14104 74205 18979 72482 14598 30963 97212 72303 26457 15488 26922 20524 106529 77219 26378 631304 56185 56360 170439 100043508 56794 108099 76267 74522 19215 12408 12894 56473 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors 12325 54376 17246 238276 18751 12322 17920 12323 108058 11771 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 19247 15382 98053 67710 17749 100043714 12402 26413 14388 14178 67112 18708 327826 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 319944 209357 98053 67710 17749 100043714 66464 68776 99730 13872 23894 226182 66467 24074 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 57296 13858 69077 66997 17246 12387 26443 26444 19170 53325 19181 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis 18016 12229 245880 229709 12502 17909 17918 330319 12631 105855 22376 12928 242687 330662 17886 26413 14083 68089 234779 66713 18708 329165 74117 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope 19041 68668 66203 317653 109620 66344 240633 64058 18772 70166 227937 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response 54722 26413 12367 12261 69146 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase 58802 18573 241489 16533 18126 23984 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere 78303 57321 67710 319181 22589 319183 21750 15270 17749 319182 100043714 625328 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling 15234 14388 18708 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint 228421 226849 225849 26931 21770 26932 68097 73804 381318 18221 19047 232987 226747 108000 103468 12615 234865 66570 17222 68612 68999 668450 66156 216965 625534 445007 56455 66977 13427 66468 110379 13424 57294 102920 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals 19247 22253 13176 PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy 13819 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism 234724 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction 56217 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants 14255 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 27370 67891 67248 629957 100039316 100038991 100041766 666669 666899 27207 66481 225058 633683 432502 100042986 19989 625646 100042740 19899 75452 19934 75617 57294 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 11651 26443 26444 19170 19181 13001 57296 69077 66997 100039026 54484 23797 68031 14302 11652 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs 216963 207565 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection 16476 12229 26416 13479 229709 17909 17918 105855 22418 13035 18749 14369 19084 12928 242687 330662 19087 69146 11491 68089 14598 234779 66713 74117 18438 12267 241275 245880 12502 14687 58861 330319 18439 12362 13057 66824 22376 67955 14678 17886 26413 14688 14083 14704 14696 14693 329165 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism 50798 19025 24060 20442 18010 20443 26938 54613 20440 50877 20447 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 433759 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) 192119 54196 75705 12193 13684 625328 104625 58184 319149 78303 319181 21679 319183 15270 319182 18983 20815 18458 75605 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 18749 19084 19087 54376 19418 216963 17246 238276 207565 16519 110637 14658 22343 14809 328699 16516 18751 12326 14402 17920 12322 14397 14678 12323 242274 108058 11444 11447 12325 170483 26413 16521 16513 242425 14688 14409 108099 14408 231252 64011 241113 14704 110304 14696 14693 11771 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development 18088 11651 333639 103988 16334 23797 15376 18012 18609 246086 19213 11652 378435 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 54722 14056 319149 245688 78303 319181 319183 15270 319182 625328 18969 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium 109242 71909 53413 28135 56297 17997 207911 214444 67161 68097 53869 18764 245866 71492 81896 67590 52906 106633 76411 12589 264134 319757 66061 232987 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 104318 16328 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 67891 67248 100038991 100041766 666669 666899 56438 26443 66855 26444 19170 19181 57296 68098 69077 432502 66997 100042986 19989 625646 100042740 19899 19934 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 238505 54219 22072 68421 21452 77697 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members 264064 21781 211586 170749 19401 11848 19165 433759 17129 17872 21808 12166 12402 11479 12167 19047 14479 51813 22284 12168 100039623 20901 12622 11705 100042305 16410 17927 17928 233833 21423 21812 26413 17128 17283 109689 12579 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 18148 17865 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily 106795 22778 101631 14377 625328 433759 18534 319149 245688 78303 319181 319183 15270 319182 234366 70802 228880 11538 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 72303 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression 16476 233833 98053 13006 20843 67710 14228 268903 100041004 22632 17749 100043714 625328 433759 100043508 99982 319149 78303 319181 319183 15270 319182 193796 17863 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 97212 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling 19247 21687 11602 18708 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors 192119 75705 58184 12193 13684 18983 18458 104625 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12427 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 22632 56438 229615 68240 19891 23894 19718 209357 56505 69745 11546 108679 13194 13872 19358 69263 19359 22591 19687 26895 26894 66467 18538 106344 72151 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance 238055 11772 11771 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events 11444 11447 231252 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation 384783 26413 16334 16367 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria 14939 18107 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling 19247 16451 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism 433323 66190 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs 27370 629957 100039316 100038991 666899 56438 66481 225058 100042986 16825 625646 100042740 67891 67248 666669 27207 26443 26444 19170 633683 19181 57296 69077 432502 66997 225363 67031 16870 17690 19989 20562 15399 19899 12830 14852 19934 18458 75617 57294 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 264064 56406 20249 68801 216154 170826 625328 234959 14311 51813 78303 319181 11770 67800 15270 70208 23945 21664 14245 23989 12568 67279 319149 319183 319182 16475 11520 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants 16590 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 27370 16341 13685 75705 629957 100039316 13684 27207 66481 225058 633683 67204 26905 27979 18458 75617 56347 57294 223691 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing 18207 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events 229709 18749 19084 12326 12322 19087 12323 108058 12325 14675 26413 18573 18798 207565 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus 76500 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane 269180 17772 75669 170749 67073 101490 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin 14061 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation 12819 192897 12829 12835 12406 16949 19035 12822 16950 18810 69675 30800 21892 12816 12830 12153 17393 12821 17395 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle 22343 12889 327814 68507 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 12326 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) 74126 22644 66435 75841 66967 66597 108687 320011 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation 17128 100038891 18999 12387 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling 18854 384783 19247 11651 227743 16334 83409 17246 54484 56716 252870 11652 117150 320207 228775 15234 14056 14388 245688 11839 14178 67112 22084 226849 16476 225849 241915 26931 21770 26932 12151 15184 12418 433759 13001 99982 16590 100039026 77125 15937 14255 14170 83379 68031 268980 14302 13653 18708 234366 98432 67605 327826 20613 16367 233833 17874 12064 13649 26443 26444 19170 16179 19181 57296 26413 69077 66997 23797 30955 19354 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis 19766 54722 22030 14102 12539 21933 18571 12362 12367 67245 69146 16396 11797 208092 66700 11796 14939 22195 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 12229 213498 14688 19418 207212 442801 14704 14696 11848 14693 277360 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease 26416 11651 18749 56438 19084 19087 16396 24060 114715 114716 18015 101809 319944 103468 19069 98053 70699 67710 234865 108138 110135 18571 14161 20833 58992 73711 109821 66464 68776 14058 99730 14061 22088 14071 67123 99571 208092 21826 100088 140474 66700 66548 445007 330267 226182 207596 24074 224697 18107 223838 13716 20356 110379 17829 29873 18636 15212 233826 230073 74153 216227 11772 667370 11771 28084 226849 225849 26931 21770 26932 12539 59079 18673 26372 16449 11928 11931 11933 18708 11682 327826 16367 12502 14687 58861 12057 17222 68612 17874 68999 56371 668450 66156 12578 16179 633683 66603 20014 252903 66383 11774 103963 68652 53975 14376 68292 15007 23797 109689 69038 208884 19345 20815 20387 13135 12982 75617 57294 27370 19247 384783 56217 629957 100039316 233870 230398 16451 14366 170743 22418 233405 14368 66481 14369 57437 77573 225058 192656 107895 54721 71951 20442 20970 20390 20443 75669 66589 80743 20440 14735 56480 20447 105722 11652 14734 384091 666609 16171 67075 257630 107607 103534 672511 108687 269181 27207 71732 69035 14688 14704 14696 231380 12447 14693 18969 16476 99412 54722 21781 15382 13557 13858 211586 17909 333639 17918 18131 71514 12928 330662 69146 12402 14104 22589 64340 233073 14255 18438 12267 50798 19766 17087 54196 21898 22030 13684 100041766 12064 103988 21812 109905 26413 26395 26396 11992 19165 100039623 109900 100042305 234779 17161 19025 14228 320207 54219 14939 68421 11806 72157 18207 11486 19035 77697 74126 12040 14170 83379 268980 67605 69162 67891 14235 12737 58194 12527 16542 225164 666669 54445 13016 27967 226144 16177 12259 15208 70616 20980 77974 17532 13380 67959 432502 14184 100040603 63953 54519 19989 18646 30955 226861 19899 67439 64051 19934 78781 20646 20538 319625 192159 20537 13479 74326 76007 14025 67422 13123 53945 75956 26361 214763 666899 66101 12041 217303 20516 75475 15203 22174 18400 234852 20168 66055 12047 68816 215114 100042986 68879 107723 17069 625646 668218 100042740 244373 230861 22083 208624 11610 17075 67418 213539 54633 68219 67248 70297 56445 20193 74104 18391 13521 57261 57905 68479 66642 84035 100732 20521 228005 17060 15569 242705 13191 381903 16834 16450 269378 60321 67529 104245 14469 246728 16649 17713 227095 54167 50493 80509 14678 12846 14377 14387 14385 14598 75612 13072 110115 105193 15926 67824 243382 229709 18010 21452 66999 19047 53412 28253 238505 13806 100043508 100038991 217214 21351 18439 12362 66824 67955 15234 14388 11839 67160 14178 67112 22084 15353 99982 108664 12721 19349 18126 68981 20656 53379 20540 17886 69263 26909 106344 72151 19367 18854 12021 227743 225182 68240 19891 17246 18148 56716 22427 19718 107392 71279 14815 13001 16590 100039026 12261 330319 13057 13649 216965 56455 13427 14083 13424 19354 329165 12234 12229 110279 68097 13035 105855 16621 242687 11491 12988 11504 68089 26403 66713 74117 17395 241275 245880 209357 56324 22376 23989 59069 12568 13872 67279 14056 319149 245688 66467 319183 319182 50724 60406 264064 216154 15184 17749 100043714 625328 14583 433759 234959 76580 23894 51813 78303 319181 15270 101739 70208 234366 20202 192292 12387 26443 26444 12326 19170 12322 12323 19181 108058 12325 57296 17128 69077 66997 26363 18563 12571 18458 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery 27370 384091 666609 629957 100039316 27207 66481 225058 633683 66603 53975 75617 57294 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 15488 26378 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 16542 668218 268980 18708 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 19247 14388 67112 18708 327826 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor 27060 140494 19247 384783 66144 242341 228775 26413 16334 14388 75669 14178 67112 14170 14255 83379 18708 108664 11964 54411 327826 11652 16367 18576 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis 80908 CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly 66222 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis 16204 22236 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs 68219 54196 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation 18751 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 13001 57296 69077 66997 100039026 56438 26443 26444 19170 19181 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins 109905 14083 110135 54519 14161 12928 99571 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport 17919 11831 14688 53869 14704 18749 14696 19084 14693 19087 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters 107723 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus 100039623 225164 16450 100042305 109689 19165 11491 16396 76580 16449 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation 66419 50529 100040519 233870 66230 74600 66242 94067 64656 68836 66845 94065 57312 68572 66121 66258 18120 14548 56280 27393 69956 56284 353242 118451 67681 66399 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA 57296 69077 66997 26443 26444 19170 18458 19181 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 68240 19687 19718 19891 18538 106344 56210 72151 71890 69263 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 22027 238055 14319 11816 11806 20288 71145 117158 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System 11839 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 11651 17246 54484 23797 22084 11652 67605 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib 12539 59079 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection 101739 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly 66821 380840 17711 544717 15526 100900 67003 66694 SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer 14388 12539 59079 13649 18708 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria 54722 69146 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade 71951 20970 14735 14058 14061 14071 14734 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis 208092 54722 66700 14939 12362 12367 69146 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 11886 108664 11964 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 19090 233900 68366 320311 108089 103737 100041766 78303 319181 22210 319183 18538 15007 319182 22083 22209 22195 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion 21743 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 225058 633683 432502 225363 100042986 67674 19989 625646 100042740 19899 14852 19934 75617 57294 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling 69065 14598 75475 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling 16451 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation 17075 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism 20390 20387 12982 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression 17764 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 76890 11848 13649 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer 12402 14388 12539 13649 18708 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 64051 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA 74326 75956 66101 66055 68816 68879 67418 384091 103468 54633 666609 19069 68219 98053 70699 67710 234865 57905 68479 66642 228005 24128 445007 60321 110379 15382 17749 100043714 64340 233073 53817 225160 386612 73666 68981 54196 53379 13684 237859 27967 20630 76167 14105 56335 76522 70616 230596 19134 70767 72654 56194 67959 244672 66053 18949 238831 77644 71715 78372 67439 209003 27756 67229 20646 70312 227707 192159 66618 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 108099 68465 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 140474 17829 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking 75964 67091 74030 68365 76308 11651 14567 224617 53869 260302 72433 93739 211922 68328 76954 11891 19326 69440 70296 229541 72121 68449 60409 320714 78232 216131 245886 56486 19349 11652 56382 23797 19345 22084 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation 100043508 68240 19891 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly 192897 18810 12821 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway 22151 238463 22142 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 67710 17749 100043714 72634 17864 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity 26413 16590 21425 13722 23797 105148 12387 17342 22771 11694 433759 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin 57296 69077 66997 17222 68612 68999 26443 668450 26444 66156 19170 19181 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins 11797 20230 14083 109620 12387 20740 18810 12367 18772 269582 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 103988 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 11444 11447 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 109075 26416 70640 66583 11651 72544 50911 69639 72662 227715 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 69162 75669 15007 110379 80898 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 26931 11651 227743 17246 12427 228829 23797 67338 56716 252870 11652 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 21351 21881 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer 11651 227743 17246 23797 56716 22084 11652 67605 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes 13072 110115 13123 269378 14598 17161 75475 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 319149 78303 319181 319183 15270 319182 625328 75605 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation 233833 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 14366 22418 18751 11772 11771 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 67065 218832 70408 17749 100043714 67005 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis 13006 140557 20843 50878 217716 56739 77053 625328 225182 68240 19891 319149 78303 57321 319181 319183 21750 15270 319182 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway 22419 208846 106042 14366 93840 22418 14368 11848 14369 26443 18751 26444 19170 19181 57296 69077 66997 19354 11772 11771 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants 14255 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 12539 59079 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 12477 16183 20371 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants 19247 14255 18708 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer 17128 21812 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 97212 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands 12064 433759 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay 109075 54196 66583 72544 76014 68533 231386 112403 24128 50911 69639 72662 227715 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 26395 26410 12234 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors 21388 15257 18091 18159 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway 14678 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME 18979 269823 22236 28253 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell 12402 58194 13858 56324 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD 75475 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle 56382 12447 73296 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination 209357 23894 66467 75316 21429 17749 100043714 13872 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 13479 66447 14598 56615 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events 12229 207911 26361 18755 14061 433292 14064 65086 57260 14675 233080 213788 104418 21334 14688 235036 30044 12424 18441 14704 18442 14696 246691 331374 14693 14745 16963 381810 225642 68039 56533 14459 19735 78134 53978 210198 58182 12061 12062 269060 217480 18708 23945 22068 233081 58861 13649 26413 18798 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs 108099 241113 207565 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS 99010 85031 225845 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation 19718 69745 66634 12544 69270 272551 69263 68240 19687 19891 18538 106344 72151 18969 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 20390 20387 12982 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation 225642 233081 14688 12387 14607 12591 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization 18708 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress 12571 12578 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins 21334 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance 11806 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions 57810 RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle 624814 19299 74194 50875 12539 53382 59079 232339 93840 109620 20355 233877 380664 16709 216197 16449 227937 233489 21927 216963 386750 239027 56419 212285 18708 70497 12261 327826 224480 238505 320795 109333 208846 330319 67784 13058 13057 14570 20740 11854 17920 244418 270163 14467 66871 213498 195727 19249 207212 442801 18844 226751 19354 329165 13726 223870 214804 110279 11464 75409 269682 105855 84004 223254 27984 242687 12988 11671 66087 18221 404710 104445 22284 23912 19418 109711 26403 14269 277360 241275 245880 76117 263803 54004 56324 20401 22376 59069 13830 66898 69668 71544 544963 21763 67299 11352 94221 213783 14270 106504 117600 94190 54411 225358 12468 219140 26934 11848 330662 98386 53817 19349 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation 384783 11848 18708 16367 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 18554 20014 13001 103963 100039026 14376 12387 69038 13135 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 52150 16530 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 57296 69077 66997 26443 26444 19170 12234 19181 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 233833 14460 319149 78303 319181 319183 15270 319182 22761 208043 625328 433759 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism 11677 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 17128 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation 11848 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine 78303 57321 319181 319183 21750 15270 319182 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 225642 233081 14688 12387 12591 SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR 12402 19247 58194 14388 13858 11839 56324 13649 18708 12988 11491 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling 13649 20459 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 69082 66632 225363 69740 13494 105638 14058 14061 271970 545260 14071 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes 13016 21415 433759 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade 667277 12259 14061 17221 56373 12902 93721 109828 12260 12279 12267 14962 12262 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation 98053 67710 14178 17749 67112 100043714 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function 76007 13858 625328 433759 18554 13001 99982 78303 319181 100039026 20901 17246 15270 13345 75339 20613 233833 192173 56805 16601 18746 114142 13016 12387 26443 21423 26444 19170 19181 20014 26413 57296 14056 103963 319149 69077 245688 66997 14376 319183 319182 69038 15376 13135 53325 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones 433759 15353 99982 319149 245688 78303 319181 319183 107392 319182 50724 234366 60406 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling 382056 56406 17087 21898 238055 52466 268903 70461 19377 17260 12013 11806 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism 103468 16329 104015 19069 114875 70699 234865 56727 54384 269180 76500 445007 16330 271424 102954 110379 217837 234779 320404 18798 269615 18799 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells 17075 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants 14388 12539 59079 13649 18708 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere 19687 19718 57321 21750 18538 72107 108689 69745 106344 72151 69263 18969 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation 67112 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling 12229 234779 18708 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 20656 14377 11651 109648 11604 14815 59092 103988 433759 18534 17128 16334 23797 11652 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint 12442 57296 69077 66997 26443 26444 19170 19181 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 208092 66383 66700 75669 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) 19718 18207 69745 26430 18970 11546 69263 68240 19687 19891 18538 106344 72151 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation 76007 110279 67529 244373 18708 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus 103468 19069 445007 70699 234865 110379 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 11839 13649 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 192119 68626 11727 PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism 225642 233081 53413 17918 17228 13035 12387 11891 12876 14607 16790 12591 76703 57394 16325 16334 12873 13809 16000 67475 14688 11421 56373 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling 54721 50498 16451 12931 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation 18854 241915 20230 69260 12151 11835 22658 22337 14815 19401 12418 229615 433759 212712 17246 18148 15204 17342 22427 103468 19069 13006 70699 20843 234865 268903 108138 13016 22591 445007 18538 110379 67711 67241 55989 21974 67872 223870 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR 22027 54445 19141 170743 72029 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis 11797 19766 11796 22030 14102 12539 21933 18571 67245 16396 22195 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 16476 12229 26416 21770 192656 26410 66589 17260 20202 17087 21898 22030 20193 107607 110135 71966 14161 17874 26940 69721 59025 67245 16179 99571 26413 26395 68652 12234 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling 12402 26413 19247 67112 327826 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 12402 26413 19247 14388 14170 83379 18708 327826 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle 22284 53382 216963 26403 20740 59069 18708 270163 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle 74126 22644 66435 75841 66967 66597 14376 108687 320011 19359 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions 12933 12934 18845 140571 22240 20361 67784 12631 11848 12568 17886 213498 20356 77579 18844 65254 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 19247 14388 14178 67112 18708 327826 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME 22236 15483 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis 26416 12555 12561 12386 17260 12558 12387 18209 17927 21423 17928 57810 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation 103468 100088 445007 70699 234865 110379 226747 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening 12293 12287 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling 11651 12539 59079 23797 13649 17179 11652 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 217666 98314 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 14460 19247 18854 241915 319974 12151 20371 22761 208043 12418 625328 433759 16396 56353 13001 78303 319181 100039026 16825 15270 12981 16880 241196 233833 26443 21423 18751 26444 19170 19181 57296 12477 319149 69077 66997 319183 66923 12571 16183 319182 17863 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 17087 21898 68652 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization 18854 252870 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 13380 22418 84035 20377 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol 66965 67049 108943 76367 328162 69786 67674 229780 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway 208836 68240 19891 14088 237211 67196 330554 55947 71711 268465 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state 17222 68612 68999 56438 56371 26443 66634 668450 26444 66156 19170 19181 57296 69077 66997 12427 57441 18392 12447 18393 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines 20296 20299 252837 16963 20311 20297 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling 14102 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription 15426 16201 20613 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 333639 246086 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases 26416 23988 624814 103468 19299 234865 445007 110379 226849 225849 26931 21770 74194 26932 50875 12539 53382 11835 59079 232339 93840 109620 20355 233877 380664 16709 216197 16449 227937 233489 21927 19047 216963 386750 239027 56419 232987 212285 18708 70497 12261 327826 224480 18016 238505 320795 109333 320271 208846 330319 67784 13058 13057 14570 20740 11854 18751 17920 244418 270163 216965 14467 66871 213498 56455 195727 19249 66977 13427 14083 207212 442801 18844 13424 226751 19354 329165 13726 223870 57294 102920 12229 214804 110279 11464 14026 68097 75409 269682 105855 381318 84004 223254 27984 242687 12988 11671 66087 18221 404710 104445 22284 23912 75669 19418 109711 68089 26403 226747 66713 74117 14269 108000 277360 241275 245880 76117 263803 54004 12615 66570 56324 20401 22376 59069 13830 66898 69668 192176 71544 544963 21763 67299 319149 625534 11352 94221 319183 66468 17283 213783 319182 77579 14270 106504 117600 94190 54411 225358 16594 12468 219140 228421 26934 73804 11848 625328 330662 98386 99982 78303 319181 15270 53817 19349 20202 12631 12387 17886 26413 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine 791260 12846 17161 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors 22095 14309 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 252903 15007 108664 11772 11771 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD 269378 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux 233833 104263 99982 67484 11812 218214 11813 11816 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown 12442 103468 19069 70699 14245 234865 382030 18751 380664 217718 59126 445007 110379 13726 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling 12402 26413 19247 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance 71909 109242 26416 28135 53413 100041835 17997 56297 214444 207911 67161 68097 53869 18764 245866 71492 81896 67590 52906 106633 76411 12589 264134 319757 66061 57441 382056 433771 226153 53375 76614 218630 17705 50776 230935 622408 239789 15278 208595 269951 15161 17863 21781 56406 170826 15526 26379 17260 232987 233833 20656 70461 76816 54130 12326 219103 22142 68475 69654 18536 208518 381644 56455 236266 108099 13427 99100 214552 241113 103733 13424 219072 104318 16328 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily 12387 625328 18104 71389 319149 12006 16002 78303 241128 319181 319183 15270 319182 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis 67054 231327 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation 14675 14688 14704 14696 14693 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation 80982 15366 56398 15212 20544 109685 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage 12367 69146 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules 12502 14026 16428 22376 234779 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation 20202 12229 17087 21898 20193 13058 110135 17874 13057 14161 26443 26444 19170 19181 99571 57296 69077 66997 246278 15007 20333 57743 16410 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 17921 97031 381375 193385 140492 241431 83762 20740 12340 17886 67972 16533 231252 26875 140476 56506 13860 216227 19684 22295 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 233833 17128 100039623 100042305 109689 19401 17927 21423 19165 17928 21812 21808 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade 109821 20720 14058 14061 105722 14071 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) 26413 26416 21770 21990 211770 17260 15904 13653 12568 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 12402 17128 19047 14479 20901 170749 16410 17872 21812 21808 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 11651 23797 11652 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 319625 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids 64385 631304 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 66589 17874 170743 16179 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation 384783 16334 16367 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption 20537 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism 110078 110095 77559 19309 105193 53412 14387 72157 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 20442 20443 20440 20447 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins 109075 66583 68097 72544 52679 22083 319944 19025 19718 98053 67710 68533 20833 66464 66642 68776 99730 19687 242705 13191 226182 24074 13716 17863 54167 16594 228421 17132 26934 56406 53314 73804 20926 17749 93736 100043714 20400 70122 80905 50723 12340 12523 60505 56444 13036 77622 24099 56464 15001 12902 56210 71890 19349 21423 54130 17886 69263 69654 108961 56455 26909 13427 18538 106344 13424 50911 72151 69639 72662 227715 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) 64051 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy 22333 67414 68097 100041766 13819 170731 13001 56455 108099 13427 100039026 66119 66589 22335 11793 241113 66169 13424 56480 11520 22195 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress 15526 68240 19891 219158 29810 18415 56716 72630 67605 56354 50497 213539 22791 103468 19069 70699 14228 234865 12322 12323 108058 12325 26413 100043508 445007 110379 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 19766 17087 21898 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle 50875 53382 12539 109711 53817 106504 17920 12468 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer 21812 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP 19766 22030 14102 21933 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling 238055 11813 11814 11816 11806 11807 11808 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein 103468 100088 19069 445007 70699 234865 110379 18148 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing 74326 75956 66101 66055 68816 68879 67418 384091 54633 666609 98053 67710 57905 68479 66642 228005 60321 15382 17749 100043714 64340 233073 53817 68981 53379 237859 27967 20630 14105 76522 70616 230596 19134 70767 72654 56194 67959 244672 66053 18949 238831 77644 71715 67439 209003 27756 67229 20646 70312 227707 192159 66618 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation 12402 58194 13858 11839 56324 13649 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system 58992 16621 14061 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling 16476 19247 26416 21770 192656 11797 11796 26410 66589 17260 56480 19766 17087 21898 22030 107607 100041766 71966 69721 59025 16179 26413 26395 68652 12234 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis 57296 69077 66997 244373 226144 26443 26444 19170 19181 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly 26425 269400 68523 78797 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism 13806 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia 67824 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere 233532 66578 12615 66570 56505 245688 78303 319181 319183 15270 319182 18148 102920 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation 14184 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis 229709 12502 18749 234779 19084 19087 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases 12021 22632 56505 26443 26444 19170 21812 19181 57296 69077 14479 66997 218214 15161 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 14388 12539 59079 13649 18708 REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling 54721 19247 230398 16451 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO 20564 13176 20562 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors 18751 11771 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 15366 236266 13427 99100 214552 103733 13424 219072 104318 16328 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) 20980 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding 11766 17113 21987 29816 233489 252903 11774 232946 14319 20661 14533 117197 245638 109689 75612 72685 19345 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 104245 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis 18534 268903 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels 56461 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors 12229 26416 14026 68097 23988 105855 381318 242687 18221 404710 75669 68089 226747 66713 74117 108000 241275 103468 245880 263803 12615 234865 66570 22376 192176 544963 319149 625534 445007 94221 319183 66468 17283 319182 77579 110379 14270 16594 226849 228421 225849 26931 21770 26932 73804 11835 11848 625328 16709 99982 19047 78303 319181 15270 56419 232987 224480 20202 18016 320795 109333 320271 208846 330319 12631 13058 13057 12387 11854 18751 17886 216965 26413 56455 66977 13427 14083 13424 19354 329165 57294 102920 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family 19247 11651 227743 16451 56438 12988 244373 56716 11652 67075 320207 57261 228775 14056 319149 245688 208154 319183 319182 21415 226849 16476 225849 26931 21770 26932 13819 625328 50723 76580 13001 78303 319181 100039026 26410 15270 18708 233833 12502 53859 58205 226144 12387 26443 26444 19170 19181 20014 57296 12477 103963 69077 66997 108099 21679 21678 68292 241113 23797 30955 69038 21677 13135 12234 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 233081 14607 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway 22030 53859 21942 245527 57916 21926 16992 26443 326623 26444 19170 19181 11797 57296 21937 11796 24099 69077 66997 69583 12234 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation 57296 69077 66997 26443 26444 19170 19181 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand 20202 54722 17087 21898 238055 20193 110135 14161 170743 69146 99571 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins 629114 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions 11733 53870 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes 12913 75766 56453 26427 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders 20537 103468 71279 19069 70699 53945 234865 26361 13521 103988 20516 15203 20540 20521 18400 24060 445007 107723 110379 104245 216227 28253 20538 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling 213498 77579 11848 17886 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 14245 67800 215456 68393 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin 17161 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III 208092 66700 22151 238463 22142 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 17155 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 264064 333639 225164 15184 56438 433759 19165 15208 11491 16396 16449 76580 51813 100039623 16450 100042305 109689 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C 17222 68612 68999 56371 26443 668450 26444 66156 19170 19181 57296 69077 66997 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer 14235 26413 12047 14939 18646 18148 56438 433759 54167 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 76654 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle 380840 67680 269951 68332 66052 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects 11486 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation 98053 67710 13716 17749 100043714 20833 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway 241452 242285 105014 26876 12903 216454 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching 20562 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 108961 12427 52679 59092 12447 29813 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 22427 68240 19718 19891 12021 26909 233826 106344 72151 225182 19367 69263 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription 21990 211770 15904 13653 12568 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 11848 12928 330662 20459 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 68240 19891 26909 18538 69745 RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle 320795 26934 109333 110279 11464 263803 208846 59079 14570 84004 13830 270163 404710 213498 207212 56419 18708 94190 277360 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL 17060 12402 12928 18708 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions 19041 22436 12231 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation 18969 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death 11797 19766 11796 22030 14102 12539 21933 18571 67245 16396 22195 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling 21351 68981 20656 53379 12346 16162 16161 16160 16159 16451 12631 18569 15526 12340 54721 50498 12931 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway 26413 26395 26396 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade 19247 384783 228775 26413 16334 14388 75669 14178 67112 14170 14255 83379 18708 327826 11652 16367 18576 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 104318 16328 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism 54338 20522 109672 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 12064 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 19247 14388 18708 327826 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 238055 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 20442 20443 20440 20447 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism 52710 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 56187 66813 64058 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism 18534 75894 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling 54721 16162 16159 50498 16451 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells 12387 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 242705 21781 13557 211586 12571 12447 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis 20442 20443 70484 54371 54613 53625 56386 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 54196 75705 13684 18458 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 56794 20524 16922 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle 53382 106504 17920 12468 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin 57296 69077 66997 12427 18392 56438 26443 66634 18393 26444 19170 19181 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 78394 216987 66181 27993 67205 245474 27966 59028 100608 18572 67674 223499 213895 100041622 72554 55989 98956 622491 234374 73674 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB 18749 19084 19087 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity 57296 69077 66997 17246 26443 26444 19170 19181 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli 109075 14381 26416 70640 66583 11651 72544 18749 56438 19084 19087 12861 12862 100041785 103468 382056 19069 70699 234865 15926 228775 445007 110379 17764 233826 18442 27060 225849 66144 15526 12034 242341 11964 233833 70461 17222 19377 68612 380975 68999 56371 668450 66156 12578 633683 100043508 23797 75617 57294 27370 629957 100039316 100038991 66481 225058 11863 52466 11652 21351 18439 27207 71389 11839 14688 14704 14696 12447 14693 20821 16476 21781 13557 211586 13819 12340 106766 20459 56444 57321 21750 67204 26905 219158 29810 18415 108664 72630 56354 50497 63873 22791 20656 17087 21898 100041766 12013 26570 75766 26427 12913 26413 238055 12427 56453 227743 50932 26921 101148 71978 17872 277854 71765 58226 230676 68240 56702 19891 14957 50708 54409 83409 26408 17246 66403 74142 50907 16410 53417 98402 28146 56716 71962 78943 319481 29806 67305 15364 68090 17752 14228 14257 268903 58233 17750 18613 14950 56032 100043858 12580 11806 11835 14815 74126 13001 69065 100039026 67605 69162 67891 109333 16542 666669 13058 13057 17436 54130 69654 56455 432502 13427 14083 19989 13424 19899 16475 19934 12234 68097 666899 100042986 625646 100042740 213539 67248 74322 56445 14056 18104 242705 319149 13191 245688 319183 319182 50493 56406 241915 12151 12418 625328 14583 78303 319181 15270 17260 21881 22027 11927 12387 26443 26444 19170 12322 12323 19181 108058 12325 57296 69077 66997 12571 50911 69639 72662 12579 227715 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME 272428 107146 72303 435528 71773 56448 552899 233801 436059 94215 22236 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease 98053 14388 67710 14178 17749 67112 100043714 18708 327826 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids 228421 226849 225849 26931 21770 26932 68097 73804 381318 18221 19047 232987 226747 108000 103468 13006 20843 12615 234865 66570 17222 68612 68999 26443 668450 26444 66156 218914 19170 19181 216965 57296 625534 445007 69077 56455 66997 66977 13427 66468 110379 13424 57294 102920 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs 56445 14228 68097 58233 11835 14815 54130 12340 69654 56444 100043508 13191 56455 13427 13424 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines 214572 319149 245688 66923 15270 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins 109620 12387 12367 18772 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response 12021 56438 26443 26444 19170 13194 14050 11785 19181 57296 69077 14048 78303 66997 319181 319183 15270 319182 193796 15204 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation 19056 229709 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage 12367 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited 19766 22030 14102 21933 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 19766 22030 14102 21933 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis 20866 269717 18439 110891 20541 22068 18438 67972 11941 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER 68240 19687 19718 19891 18538 69745 106344 72151 69263 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport 19299 74104 226144 26443 26444 19170 19181 57296 11305 224742 69077 27404 66997 67204 244373 26905 11806 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry 71951 17087 20970 21898 13649 14735 19345 14734 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease 70640 27756 RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs 18016 77579 17886 192176 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) 18439 13035 12362 66824 67955 18438 69146 12267 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA 215456 99010 102247 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 12537 236266 13427 99100 214552 103733 13424 219072 104318 51885 233276 16328 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm 17128 12387 15376 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se 269378 14711 12411 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants 14255 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K 69568 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib 12539 59079 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels 433759 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 13123 13122 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts 19299 56050 15488 13123 13122 17117 26459 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 12367 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) 223604 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 19247 14388 67112 18708 327826 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils 21892 16949 16950 69675 12153 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 109905 11651 14083 110135 54519 14161 12928 14061 11551 12988 99571 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus 103468 19069 445007 70699 234865 110379 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 16002 16000 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA 56438 68240 19891 57441 18392 18393 19718 17222 68612 68999 69745 56371 26443 66634 668450 12544 26444 66156 69270 19170 272551 69263 19181 57296 19687 69077 66997 18538 12427 106344 72151 12447 18969 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 320795 99982 319149 78303 319181 319183 11835 15270 319182 625328 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 16476 13710 264064 21781 13557 211586 11651 333639 18131 54613 15184 56438 625328 19165 433759 11491 16396 16449 76580 51813 78303 100039623 20443 319181 15270 100042305 17242 233833 14257 225164 67784 13649 26443 26444 19170 15208 19181 57296 319149 69077 14939 66997 16450 319183 211652 319182 14128 109689 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 11848 INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling 16451 60504 60505 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions 109711 50791 20740 18708 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud 14573 15396 20472 14048 15431 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 97212 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin 16334 16000 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 234664 66199 242418 74251 415115 13819 56438 26374 212919 72194 53417 231670 226541 100041766 69754 77113 26443 26444 108679 207952 19170 13194 231672 19181 101358 57296 26895 69077 26894 245688 14794 66997 214931 217217 117589 223499 74646 233902 233826 54638 83962 66498 30838 59043 233805 12234 73828 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 106766 20459 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production 13479 58861 14598 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins 20014 103963 67075 18107 68292 69038 16649 11806 13135 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport 68015 66414 67264 100041835 217666 67388 70456 67105 225887 12861 66052 67680 226646 624814 18293 12862 68332 67003 100041785 66694 66089 18115 66690 98314 69702 170718 26940 17705 67044 56705 269951 108755 17711 22333 52892 15526 74011 17721 380840 17722 17719 544717 71803 100900 66821 380975 17436 66359 17449 52469 17448 68198 66091 18563 66416 66272 75597 100042503 230075 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome 12362 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes 69162 74126 225849 13191 68090 74322 50907 14583 28146 71765 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade 16476 19766 26416 21770 22030 107607 71966 100041766 69721 59025 16179 192656 11797 26413 26395 11796 68652 66589 26410 17260 56480 12234 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes 11813 56453 11808 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair 18207 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants 16590 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 19247 14388 14170 83379 18708 327826 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 67065 218832 70408 20823 17749 100043714 67005 SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism 574418 230779 26943 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 21781 22171 211586 629959 12427 18538 18392 12447 12544 433759 50496 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation 15234 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 20538 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis 382056 26416 20656 56406 100041835 170826 70461 433771 226153 53375 15526 76614 26379 17705 12326 50776 230935 15278 208595 108099 269951 17260 241113 15161 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 22427 12021 26909 233826 71711 268465 225182 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids 56448 64385 631304 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 12502 71326 19294 83382 20400 20612 217303 100043861 270152 15898 57781 54698 232801 15007 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential 72258 52150 16526 16530 16528 223604 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency 18563 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles 55990 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 14377 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange 22427 68240 19718 19891 12021 26909 106344 72151 225182 19367 69263 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type 13072 110115 72303 56448 13123 11864 13122 18984 631304 11863 56050 64385 74134 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea 17921 97031 381375 193385 241431 83762 20740 12340 17886 67972 16533 26875 140476 56506 13860 216227 19684 22295 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling 17532 19047 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) 17001 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 66089 22333 56705 18563 70456 17436 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism 14381 14377 74637 56398 18749 14387 68631 18639 18640 170768 14385 71951 20442 14348 20970 15366 20443 15118 17159 54371 56421 75612 14735 20544 14734 21351 103468 19069 26878 70699 77559 215015 234865 105193 13521 56386 16770 18534 110078 445007 217119 110095 83398 19309 50786 110379 29873 53625 15212 109685 14751 72157 195646 93683 14422 21770 232449 54613 15442 100043349 78923 11677 53412 66646 21881 13806 103988 80908 66681 80982 14120 18563 70484 270198 13807 108652 319625 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes 19687 19718 77622 18538 106344 56210 72151 71890 80905 69263 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex 21781 211586 629959 18538 433759 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants 14255 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D 75612 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine 12411 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 57296 69077 66997 56438 26443 26444 19170 12234 19181 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation 260302 14161 11816 625328 16334 319149 68396 22284 78303 100039623 16432 319181 20660 319183 70423 15270 232670 319182 100042305 20219 69592 11806 11808 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling 238055 17777 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases 14255 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex 68240 19687 19718 19891 22210 18538 69745 56438 106344 72151 13194 69263 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins 17222 68612 68999 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization 12819 12829 12835 12816 12822 12830 12821 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates 20133 50493 22171 18102 56520 54369 635960 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling 15234 56705 74334 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 21781 211586 18538 29813 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling 19247 384783 228775 14388 75669 14178 67112 14170 14255 83379 18708 327826 11652 16367 18576 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism 226518 230125 102570 67993 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 16202 57342 CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication 19247 56217 76007 12555 16451 12561 12558 54721 20901 17246 109711 12821 15426 16201 192176 14056 319149 245688 319183 319182 50791 192897 13858 19294 18810 625328 433759 330662 18554 11797 13001 99982 78303 319181 100039026 15270 18708 16202 57342 13345 75339 71740 20613 58235 233833 170736 12552 192173 12554 12737 56805 74202 16601 239857 18746 71908 114142 21754 239096 12738 13016 227485 230738 12387 330222 20740 26443 215654 21423 26444 11727 668101 19170 12564 12563 19181 12560 20014 57296 26413 103963 69077 66997 14376 14083 69038 15376 13135 53325 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A 14058 14061 14071 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins 19025 381903 18010 208624 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 11848 16709 16594 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 22427 68240 19718 19891 12021 26909 106344 72151 225182 19367 69263 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium 56297 207911 71492 319757 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs 12229 26413 245880 330319 14083 105855 68089 22376 66713 329165 74117 242687 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events 103468 19069 70699 234865 73711 22088 234852 67123 208092 66700 319149 445007 78303 319181 319183 319182 110379 28084 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins 103468 19069 445007 70699 234865 18538 110379 229615 21974 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis 17292 21380 17128 16825 21388 17260 18091 12387 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 12229 19247 26416 170743 192656 75669 66589 234779 56480 20193 107607 110135 14161 26940 99571 16476 54722 21770 78287 69146 11797 11796 19141 26410 17260 20202 22027 19766 17087 21898 22030 71966 54445 100041766 17874 69721 59025 67245 16179 26413 26395 16409 71398 68652 238055 17084 27056 12234 72029 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h 381903 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 13123 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 15278 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation 625328 68240 19891 78303 319181 15270 57441 18392 18393 17222 68612 68999 56371 26443 66634 668450 12544 26444 66156 19170 19181 57296 319149 69077 66997 319183 319182 18969 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation 12325 100043508 14228 56716 12322 12323 67605 108058 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins 67075 103534 108687 269181 57437 69035 107895 20014 20442 103963 20443 14376 68292 20440 69038 208884 20815 20447 13135 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 384783 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants 26413 26395 26396 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily 384091 68981 666609 20833 27967 68479 625328 21423 66055 67959 319149 78303 319181 319183 15270 319182 17927 22083 17928 20646 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport 27060 140494 66144 53945 11428 242341 15203 14319 52466 67634 108664 11964 54411 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors 75605 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation 22030 71966 69721 230073 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A 17222 68612 68999 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle 13830 66871 404710 104445 94221 216963 56419 14270 226751 70497 94190 14269 19349 277360 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription 14381 243963 26416 22648 319974 235682 11651 14377 72720 69020 11604 22658 20371 72154 56438 213011 68527 17433 18741 16396 12861 56353 50496 77827 16334 22757 193452 80902 212712 269704 17702 12862 16825 242109 12981 22690 56275 16880 244556 100041785 11906 619310 319944 72180 98053 67710 20833 66464 68776 99730 226182 24074 13716 26931 216456 26379 16449 15378 233833 14312 233107 106931 17222 68612 380975 68999 56371 668450 66156 12578 16179 23797 19247 11863 11652 384091 666609 117150 11864 12362 21415 12447 17863 22084 16476 14460 21781 211586 333639 18131 20926 93736 22761 70122 20656 54196 14102 21933 12064 103988 69263 57748 108961 26413 66494 57913 18996 12366 26909 18538 12427 70088 241113 106344 72151 12905 219022 19367 53325 56187 18854 12021 76367 69260 227743 69131 23988 66813 59092 67338 12227 66262 225655 225182 104625 208836 68240 19891 58184 14088 83409 17246 52679 15257 18983 18148 64058 56716 252870 69181 29813 22427 19718 18534 66923 75605 11835 22337 14815 19401 11816 13001 16590 100039026 13649 18751 219103 108099 229543 70422 75137 71957 77065 102209 75627 71177 69917 22284 22083 209357 68219 228829 434178 23989 237758 12568 13872 67279 14056 319149 245688 66467 319183 17283 319182 243834 14751 233060 264064 50493 17132 241915 216154 80509 170826 12151 15184 17749 22632 100043714 208043 12418 625328 433759 234959 23894 98386 51813 78303 319181 15270 17260 56461 70208 19293 70472 234366 69228 13345 17865 14660 241196 239652 192292 235028 94223 22709 109648 78251 21388 675812 18091 12387 29808 26443 21423 26444 12326 19170 12322 12323 19181 108058 12325 57296 17128 12477 69077 68744 66997 22693 21679 21678 12571 16183 272347 434377 26380 619331 21677 12579 244216 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation 19247 14255 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME 14598 14871 20860 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np 226861 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts 103468 19069 445007 70699 13684 234865 110379 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 59092 29813 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 56702 15364 14957 50708 66403 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 73711 22088 67123 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 18207 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 26413 16334 11863 11864 17246 12064 12568 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation 226849 225849 26931 11651 21770 53859 26932 227743 320207 228775 12477 26410 23797 30955 18708 56716 11652 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis 27370 629957 100039316 100038991 20768 666899 66481 225058 100042986 211006 625646 100042740 65967 67891 67248 666669 27207 75420 633683 432502 19989 19899 19934 75617 57294 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis 26413 13806 672511 71514 13035 233405 108664 12721 19349 18126 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 97212 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation 21892 12153 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle 22376 13830 14467 66871 404710 104445 216963 56419 226751 18708 94190 14269 19349 277360 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 57296 69077 66997 17246 228829 26443 26374 26444 19170 19181 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus 98404 103468 208366 19069 28088 67676 70699 67053 68626 74097 234865 66161 68045 67724 445007 110379 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions 58226 14573 12829 12835 19122 239556 12830 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 14170 83379 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling 27060 140494 16334 66144 108664 242341 11964 54411 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 19247 14388 14170 83379 18708 327826 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 26443 26444 19170 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling 20371 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion 15108 66132 52575 68291 230734 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle 67414 170731 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport 69162 99412 67091 76308 215474 207352 105522 74498 67857 66890 60409 11839 78232 216131 20333 110379 50907 104318 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle 12447 20459 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase 67857 66181 208084 57321 245474 21750 20174 12427 56505 269400 105522 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) 17874 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate 27376 66071 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 57296 69077 66997 106042 14366 93840 22418 14369 26443 26444 19170 19181 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism 241447 18010 26938 11886 432628 50877 22239 545260 74442 20597 66190 239559 93898 271970 19025 76893 17113 433323 56386 223753 227102 19156 70750 15212 14421 20698 545975 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance 18749 56438 19165 19087 58226 100039623 16825 100042305 16410 225363 67031 20356 16870 17690 20562 15399 12830 14852 11772 11771 12829 12835 13001 14573 100039026 216963 18708 327826 67891 58194 67784 666669 13649 20740 633683 213498 432502 14083 19989 18844 19899 19934 75617 57294 65254 27370 12933 19247 384783 12934 19056 18845 629957 140571 100039316 14026 22240 100038991 20361 666899 19122 66481 239556 225058 13839 319713 100042986 24046 13846 13845 625646 68089 270190 100042740 16728 244058 66713 67252 74117 623279 20741 20273 17395 68799 114873 80297 71653 67248 19699 27207 12568 56705 14388 11352 77579 14270 117600 19684 17909 11848 13448 330662 22253 13176 238276 22068 20564 12631 26443 11733 26444 53870 19170 13838 17886 19181 57296 26413 26395 69077 26396 66997 18458 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins 241915 12151 22658 12418 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization 18815 50817 17228 13035 12822 16621 12367 23948 58223 11491 73647 21808 72902 11504 30800 17381 20970 60409 71753 21892 12816 109711 12339 83995 22072 23830 16410 12153 17393 64706 12821 17395 12819 17384 16779 20649 24051 110135 18613 20648 14161 20391 17180 24052 329278 50530 23876 13717 99571 14119 14118 20650 13527 16651 12305 268534 16773 228357 12830 192897 12829 12835 12406 16949 19035 16950 18810 69675 15898 16542 16409 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance 66181 245474 17749 100043714 625328 105522 67857 68240 19891 208084 57321 78303 22589 319181 21750 15270 18148 22427 233532 19718 66578 67710 12615 66570 20174 72107 108689 56505 69745 69263 19687 245688 319183 18538 12427 319182 106344 269400 72151 18969 102920 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade 16476 12229 19247 26416 21770 192656 11797 11796 26410 66589 17260 234779 56480 20202 19766 17087 21898 22030 20193 107607 100041766 110135 71966 14161 17874 26940 69721 59025 67245 16179 99571 26413 26395 16409 17084 68652 12234 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 109075 70640 66583 11651 72544 50911 69639 72662 227715 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism 68365 240753 101490 269180 66569 75669 117150 320207 219135 67073 104015 170749 102247 54384 70568 74451 56305 12651 13001 116939 237928 56018 17772 12891 100039026 67800 75320 66586 212862 66461 85031 18708 23945 225845 27388 66443 266692 74182 68682 97212 77582 106861 14245 215456 99010 237625 240752 233552 19249 30955 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus 78303 319181 319183 15270 319182 625328 20815 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function 77974 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 19090 446099 22040 56480 268857 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 11811 56417 110532 71281 11810 TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 11806 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis 58992 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 109791 16825 18107 16870 11806 11807 216227 11808 20278 11813 11814 20277 11816 12057 20740 546729 77974 225600 18587 67442 71951 20970 14735 14734 67972 14688 26875 140476 56506 13860 19684 22295 17921 97031 258763 381375 83771 193385 258729 140492 258769 241431 258325 83762 574417 387347 57253 57254 387355 387342 387349 19892 12340 387616 170639 258752 18365 258939 16533 258961 258305 100038859 100043474 259035 19674 257917 258819 259075 259058 18310 258659 68667 18314 21906 258896 387513 257883 258587 110326 258352 237178 258287 258580 258321 259036 259034 18324 258985 17886 258267 387353 387515 241452 353148 258832 668825 238055 18330 216454 353165 231252 387348 235033 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence 233833 26413 242705 21781 13557 211586 17246 12571 100043858 12580 12578 12579 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 19056 238276 18749 19087 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib 12539 59079 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants 16590 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation 67422 18010 18131 14583 11504 71951 20970 14735 208624 14734 50798 19025 13521 21826 140474 66548 330267 381903 207596 224697 223838 20356 17829 29873 18636 15212 72157 319625 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production 18126 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins 66383 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot 18815 18792 20194 20720 20725 20719 18791 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic 56444 69654 76895 13191 56455 68097 13427 13424 54130 12340 12121 18475 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs 233833 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 71951 20970 14735 14734 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism 269642 11484 73748 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 209357 67710 17749 100043714 57905 56438 108679 13194 13872 23894 26895 26894 66467 67439 252870 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway 226849 320139 26413 225849 26395 26931 26396 21770 26932 63953 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells 12402 19247 76527 234779 18708 DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle 67824 109900 217214 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 66632 69740 105638 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC 140474 17829 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 12013 14950 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants 13016 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 54325 68801 15488 76267 56473 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System 109075 66583 20469 11651 19696 19260 72544 380711 18037 19271 18749 56438 16396 80898 319944 98053 67710 110135 14161 20833 68533 66464 68776 99730 228775 99571 226182 24074 13716 110379 74153 11772 11771 226849 225849 229709 26931 21770 26932 19141 12902 18708 233833 12502 17222 68612 17874 68999 56371 668450 66156 20014 252903 103963 68652 68292 15007 23797 69038 13135 19247 19056 16451 192656 212919 75669 22210 66589 244421 54484 76608 72194 15204 56515 22209 11652 140629 22195 57751 74132 207304 67075 231670 226541 104184 672511 69754 77113 70294 67615 68729 100041484 207952 66743 231672 56228 101358 321006 68098 14794 208154 214931 16428 217217 246278 117589 20333 74646 57743 233902 21415 231380 83962 17863 20821 30838 16594 16476 228421 26934 19041 73804 20926 93736 13819 20400 70122 80905 50723 12340 12523 60505 56444 13036 77622 24099 56464 15001 19349 17087 21898 53859 58205 100041766 216150 17886 69263 109905 108961 26909 18538 12231 241113 106344 72151 227743 52679 16410 234779 56716 19025 19718 320207 20866 19687 269717 71326 19294 83382 20612 100043861 270152 15898 57781 54698 232801 13001 100039026 69162 58194 13058 13057 226144 54130 18751 69654 56455 108099 13427 30955 13424 12234 12229 14026 68097 217303 12988 22436 244373 22083 20193 57261 22376 66642 17060 14056 242705 319149 13191 245688 319183 319182 54167 17132 56406 53314 17749 100043714 625328 76580 78303 319181 15270 26410 56210 71890 20202 12387 26443 21423 26444 19170 19181 57296 12477 69077 66997 21679 21678 50911 69639 21677 72662 227715 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases 19766 107607 54644 11848 107260 360216 230073 192656 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement 667277 12944 12259 12260 239447 11537 12262 14962 MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction 229709 50875 239556 21957 17868 17898 58226 72258 21956 52150 16526 21916 16530 16528 21954 66240 22138 24046 216459 11928 16535 17896 15257 56461 11931 11933 20273 21388 18091 59069 18159 110891 20541 12322 67972 12323 11941 108058 20866 12325 269717 223604 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs 19247 26416 384783 21770 211770 12064 11848 12928 12568 109905 26413 26395 14388 26396 21990 15904 17260 19762 13653 18708 327826 11772 11771 16367 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery 27370 15382 629957 100039316 27207 66481 225058 75617 633683 57294 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events 12325 18573 26413 18749 19084 12326 12322 207565 19087 12323 108058 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors 213788 215854 15565 15550 13492 11551 13491 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate 100038891 18999 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors 103468 19069 70699 234865 56438 26443 26444 19170 19181 252903 100088 57296 445007 69077 66997 15007 110379 101739 18148 108664 11772 12234 11771 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 192119 94223 67710 17749 100043714 75284 72322 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins 26395 26396 18571 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response 26413 12367 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema 58992 16621 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 22427 12021 26909 233826 225182 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription 16601 114142 20901 15376 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR 207911 11651 18749 19084 19087 319757 54409 215854 15565 15550 93896 74191 226304 626596 56089 13610 51801 320207 19049 387512 239530 67792 22421 23925 20890 14061 18755 29863 433292 14608 14064 76854 65086 381853 57260 64095 233080 26385 213788 106512 104418 22410 21334 19222 235036 14427 30044 19217 12424 19218 18441 30878 18442 67839 246691 14823 331374 171469 14745 20287 16963 13603 381810 227326 225642 14739 68039 381489 229709 56533 12854 14459 13349 21770 19735 387356 78134 18155 53978 210198 58182 12061 12062 269060 217480 14607 18708 23945 14687 58861 12057 13649 18751 213498 19156 207212 442801 23797 30955 109689 12229 19056 14686 14366 26361 22418 14368 14369 11551 19418 20299 252837 11652 20311 277360 20297 20296 22095 14309 12568 14675 14688 14704 14696 14693 13492 13491 18576 83771 574417 387347 57253 57254 387355 11848 387342 387349 387616 23984 18573 241489 207565 22068 12267 233081 387513 110326 109648 12326 12322 14678 12323 108058 387353 12325 387515 26413 353148 242425 353165 387348 18798 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress 67204 26905 12034 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation 26413 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling 14083 12631 68089 11848 66713 74117 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 264064 56406 20249 68801 216154 170826 625328 234959 14311 51813 78303 319181 11770 67800 15270 70208 23945 21664 14245 23989 12568 67279 319149 319183 319182 16475 11520 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation 11705 22762 19215 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation 100041835 433771 53375 15526 76614 17705 230935 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 11797 19766 17087 21898 11796 100041766 66589 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs 384091 243963 666609 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA 101739 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry 12737 217303 100732 22174 71951 20970 17069 14735 231380 18708 74153 11772 11771 14734 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell 11491 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B 17222 68612 68999 668450 66156 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) 21679 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation 264064 56406 216154 80509 12224 20528 21926 23989 230753 234959 18534 66999 67279 51813 22410 11770 70208 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 100039623 100042305 19165 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 19047 11770 18749 16204 16592 14077 23945 67469 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) 13058 13057 16410 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response 12367 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade 225600 14688 18107 237178 19674 18587 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling 12064 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 22427 12021 26909 269400 233826 225182 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection 17749 100043714 56438 23894 101739 18148 108664 319944 103468 209357 19069 98053 70699 67710 234865 108138 18571 20833 73711 26443 66464 26444 68776 19170 99730 13872 22088 19181 67123 208092 252903 57296 100088 66700 69077 445007 66997 226182 66467 24074 18107 13716 15007 110379 11772 12234 11771 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System 109075 26416 320139 76527 66583 20469 11651 19696 19260 72544 380711 18037 19271 18749 54644 56438 12944 239447 16396 12981 16880 11537 14962 319944 103468 19069 98053 70699 67710 234865 110135 14161 20833 58992 66464 68776 99730 14061 99571 140474 445007 226182 24074 13716 110379 17829 18636 15212 230073 74153 11772 667370 11771 226849 27060 140494 225849 26931 21770 26932 66144 18414 93679 224794 76295 54473 242341 67525 14126 19256 102595 332579 70110 54139 57444 16185 76025 12512 16197 19255 78892 16155 68724 18708 26949 11964 15439 16182 16367 16164 233833 19373 19374 11980 16391 12502 16178 19263 72461 227394 17222 71966 214158 68612 17874 57914 68999 69721 620235 56371 59025 72065 668450 67245 381809 66156 242700 16970 16179 223978 633683 18407 58222 20014 252903 329244 20568 103963 241197 68652 14319 224762 18813 83768 68292 237313 15007 268379 23797 21682 69038 19340 19345 24014 53856 13135 12982 67474 75617 80861 57294 16783 27370 19116 22165 19247 384783 16784 19056 72162 629957 56619 100039316 12283 16168 230398 67781 16451 140806 170743 229900 66060 66481 57437 225058 192656 54721 212919 75669 22210 66589 244421 54484 76608 72194 56480 15204 56515 105722 22209 11652 140629 22195 57751 74132 16171 207304 67075 231670 257630 226541 107607 104184 672511 69754 77113 27207 70294 67615 68729 100041484 207952 66743 231672 56228 101358 321006 68098 14794 214931 217217 117589 74646 233902 231380 83962 20821 30838 20698 16476 54722 17909 17918 19041 13819 11848 12928 18772 330662 69146 12402 14255 14302 12267 19766 17087 21898 22030 13684 100041766 216150 242274 109905 26413 26395 238055 11886 17159 234779 16410 17161 19025 320207 26940 56615 19687 27979 56347 72157 223691 16341 232449 100038891 77125 13653 69162 58194 54445 226144 16177 12259 108099 100040603 30955 216134 68365 104112 214763 217303 11717 76500 22436 668218 244373 230861 22083 77559 20193 57261 66642 17060 242705 13191 14469 246728 14751 16649 54167 66222 56210 71890 22027 19090 14387 11891 75612 80898 67005 67065 218832 70408 15926 68533 228775 110078 110095 229709 18010 15442 15526 19141 17221 56373 12902 93721 109828 12260 12279 12262 667277 18746 66681 16790 19156 19249 50498 12931 72029 12346 237211 16592 20299 20297 21351 16201 18439 12362 66824 67955 383619 15234 208154 16428 246278 20333 57743 21415 17863 16594 16923 228421 26934 73804 20926 78287 93736 20400 70122 80905 50723 12340 12523 60505 56444 13036 77622 24099 56464 15001 11793 67204 26905 108664 19349 18126 68981 20656 53379 16162 16161 53859 16160 58205 16159 21942 12631 245527 18569 57916 16992 326623 17886 69263 108961 12366 26909 18538 12231 241113 106344 72151 18854 227743 23988 14088 83409 52679 18148 56716 19718 17750 18613 20866 269717 14128 60504 71326 19294 109620 83382 20612 100043861 270152 70568 15898 216197 57781 54698 232801 13001 100039026 12261 266692 18016 68682 330319 13058 13057 20740 54130 18751 668101 69654 16409 71398 56455 17084 27056 13427 14083 13424 19354 329165 12234 12229 14026 68097 13035 105855 16621 12367 242687 11491 12988 23912 83995 68089 66713 74117 17395 245880 22376 13830 192176 544963 14056 319149 245688 11352 319183 319182 446099 22040 268857 56417 16163 17132 56406 53314 17749 100043714 21926 625328 76580 11797 21937 11796 78303 319181 15270 26410 17260 19695 54159 20202 11927 66557 57757 629114 12652 18843 11870 19152 72621 12387 26443 21423 26444 19170 12322 12323 19181 108058 12325 57296 12477 69077 66997 21679 21678 16183 18792 50911 69583 69639 20719 21677 72662 227715 18475 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 19299 15488 13122 17117 26459 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint 57296 26416 69077 66997 56438 26443 26444 19170 12234 19181 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer 264064 333639 225164 15184 56438 433759 19165 15208 11491 16449 76580 51813 100039623 16450 100042305 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes 12819 12829 12835 21892 12406 12816 19035 12822 12830 12153 12821 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER 209357 56438 229615 11546 13194 13872 19358 19359 22591 68240 19891 23894 66467 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway 11797 19766 106025 21937 11796 22030 68652 21926 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity 12325 54376 17246 238276 18751 12322 17920 12323 108058 11771 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 12040 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation 214579 12889 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes 56305 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function 12021 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 17001 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate 68240 19891 18538 69745 18969 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling 19056 229709 53859 100041766 216150 66824 26443 26444 19170 19181 332579 57296 69077 66997 68652 66589 234779 12234 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing 19671 208884 57437 70178 226016 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage 75452 69090 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle 26934 110279 75409 59079 105855 84004 380664 242687 330662 98386 104445 216963 56419 70497 18708 19349 277360 13058 13057 66898 71544 195727 19354 329165 94190 13726 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 233833 26413 16334 11863 11864 17246 14815 12064 56461 12568 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules 319655 29859 23827 20860 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions 27370 19247 56217 629957 11651 100039316 233870 230398 16451 170743 233405 66481 77573 225058 192656 54721 20390 75669 66589 80743 56480 11652 384091 103468 666609 19069 16171 70699 257630 107607 234865 27207 71732 16179 633683 66603 445007 68652 53975 15007 110379 23797 230073 75617 57294 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 230577 74776 224805 70120 67417 353172 70560 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 17161 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation 623661 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor 11551 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis 216965 19766 227743 75669 56716 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis 110135 14161 109821 14058 14061 105722 14071 99571 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 21781 211586 629959 433759 17865 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 15565 15550 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 225164 16450 11491 76580 16449 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism 67422 14377 13123 217214 11992 12041 14387 75475 14385 11504 71951 20970 20390 109900 14598 75612 14735 208624 17161 14734 13072 21351 110115 19025 105193 54219 13521 15926 21826 140474 66548 67824 330267 381903 207596 224697 223838 269378 20356 17829 29873 18636 15212 68421 227095 72157 243382 18010 18131 11486 14583 21452 77697 12040 53412 50798 238505 26363 18563 20387 12982 319625 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS 26416 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids 272428 107146 435528 233801 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins 68404 433931 21684 21683 56047 66459 329777 71003 14276 269295 276846 170745 64931 17069 246190 114654 17068 237847 11650 68468 14756 230801 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS 17161 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 71803 104245 216227 20538 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors 74191 78134 235036 18441 18442 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 19766 230073 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation 17132 26413 212712 11835 68527 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane 27370 629957 100039316 100038991 666899 66481 225058 100042986 625646 100042740 28146 67891 67248 666669 217337 27207 27058 633683 432502 19989 57743 19899 19934 75617 57294 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection 18854 68097 234852 78303 319181 103468 19069 70699 234865 13649 73711 22088 67123 208092 14056 66700 319149 445007 245688 56455 319183 13427 319182 110379 13424 28084 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres 16410 50530 23876 21808 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 26931 11651 227743 17246 12427 228829 23797 67338 56716 252870 11652 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism 22436 14544 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 320139 384783 19247 16451 18749 56438 19671 57437 70178 226016 12988 54721 83409 19418 114715 114716 26403 12981 320484 69601 18015 101809 54153 20741 80297 110135 14161 21687 70727 225724 18612 99571 15234 56705 11839 14178 67112 226849 16476 225849 26931 21770 26932 18673 14573 16590 19047 16185 14255 14170 83379 18708 327826 16367 233833 19373 19374 13649 20740 26443 26444 19170 12322 12323 19181 242274 108058 109905 12325 57296 17532 26413 26395 69077 26396 66997 63953 14083 54519 16183 109689 208884 12982 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 226849 19247 225849 12477 26931 11651 21770 26932 23797 11652 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH 50493 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation 57321 21750 108689 18969 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation 11504 246179 20442 24060 243853 67843 20443 75847 228366 20440 20447 56386 74653 14537 272411 21826 140474 171212 66548 78754 330267 108760 207596 212996 224697 71685 223838 80294 20356 17829 53625 18636 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 100038891 18999 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 16521 16513 242425 14688 16519 14704 14696 14693 16516 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome 57296 69077 66997 18749 56438 26443 26444 19170 12234 16396 19181 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 27370 16341 75705 629957 100039316 13684 27207 66481 225058 633683 67204 26905 27979 75617 56347 57294 223691 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA 75705 58184 13684 18983 18458 104625 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism 80982 15366 15118 56398 15212 20544 109685 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation 109075 66583 68097 72544 52679 22083 319944 19025 19718 98053 67710 68533 20833 66464 66642 68776 99730 19687 242705 13191 226182 24074 13716 17863 54167 16594 228421 17132 26934 56406 53314 73804 20926 17749 93736 100043714 20400 70122 80905 50723 12340 12523 60505 56444 13036 77622 24099 56464 15001 12902 56210 71890 19349 21423 54130 17886 69263 69654 108961 56455 26909 13427 18538 106344 13424 50911 72151 69639 72662 227715 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 15488 12908 17117 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions 11733 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 320139 384783 16451 56438 19671 57437 70178 226016 12988 83409 19418 114715 114716 26403 12981 320484 69601 18015 101809 54153 20741 80297 110135 14161 21687 70727 99571 15234 56705 11839 14178 67112 226849 225849 26931 21770 26932 18673 14573 16590 19047 16185 14255 14170 83379 18708 327826 16367 13649 20740 26443 26444 19170 12322 12323 19181 242274 108058 109905 12325 57296 17532 26413 26395 69077 26396 66997 63953 14083 54519 16183 109689 208884 12982 METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance 791260 12846 17161 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization 74498 99412 12442 26413 76308 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling 16163 320139 19247 13035 56438 54473 69146 19256 192656 26410 77125 66589 19255 56480 16182 16178 22030 107607 71966 12362 17874 69721 59025 26443 67245 16177 26444 19170 16179 19181 57296 26395 69077 66997 68652 19249 12234 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors 17246 17342 229615 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC 54219 21452 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase 12442 71909 28135 17997 214444 68097 381318 18221 226747 108000 103468 13006 20843 12615 234865 66570 218914 625534 445007 66468 110379 226849 228421 225849 26931 21770 26932 73804 13001 19047 100039026 232987 76816 54130 217718 219103 59126 22142 68475 69654 216965 18536 208518 381644 56455 236266 66977 13427 99100 214552 103733 13424 219072 104318 51885 233276 16328 57294 102920 NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis 71951 20970 217119 215015 29873 14735 14734 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 19056 229709 56619 53859 100041766 216150 18749 66824 26443 381809 26444 19170 19181 332579 140474 57296 69077 66997 68652 66589 17829 234779 12234 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 27370 16341 629957 100039316 100038991 666899 66481 225058 100042986 67204 625646 26905 100042740 67891 67248 75705 13684 666669 27207 633683 432502 226982 19989 19899 19934 27979 75617 56347 57294 223691 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 225058 633683 432502 100042986 19989 625646 100042740 19899 19934 75617 57294 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi 20443 18131 54613 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling 16880 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes 22072 68421 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH 14598 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 97212 26922 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors 14058 14061 14071 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts 20494 26459 16204 28253 170460 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR 19247 15382 98053 67710 17749 100043714 12402 26413 14388 114715 14178 116701 114716 67112 14170 83379 18708 327826 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex 226849 225849 26931 21770 26932 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases 75452 69090 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors 21937 24099 21942 245527 57916 16992 69583 326623 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 18845 18844 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions 244373 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB 12325 12326 12322 207565 12323 108058 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition 21781 13557 11651 211586 22171 629959 433759 71978 50496 20459 68240 19891 57441 18392 18393 17865 11652 26443 66634 100043858 12544 12580 26444 19170 12578 19181 57296 242705 69077 66997 12571 18538 12427 23797 12447 12579 18969 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 110135 14161 18673 12322 12988 12323 108058 99571 109905 12325 26413 26395 26396 54519 109689 26403 FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct 15412 15403 15904 16869 12387 18510 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing 15382 98053 67710 17749 100043714 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses 214763 22083 11806 12259 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) 27370 629957 100039316 100038991 666899 66481 225058 71978 100042986 625646 100042740 67891 67248 666669 27207 633683 432502 225363 67031 19989 229512 103677 19899 14852 19934 18458 75617 57294 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors 227683 14528 11651 20751 11428 15926 67426 71365 217707 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling 12402 26413 19247 327826 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping 209357 23894 98053 67710 66467 17749 100043714 13872 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 16476 99412 20656 12568 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane 117150 104015 68365 320207 240753 240752 269180 17772 19249 219135 67073 30955 18708 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism 238505 26363 18563 54219 68421 21452 77697 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection 27370 629957 100039316 100038991 17749 100043714 666899 66481 225058 100042986 625646 100042740 103468 67891 19069 54196 98053 67248 70699 67710 234865 666669 27207 633683 445007 432502 19989 110379 19899 16649 19934 75617 57294 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE 54445 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 382056 56406 268903 70461 19377 17260 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints 12442 12021 225182 68240 19891 78303 319181 15270 18392 15204 18393 269582 22427 19718 26443 66634 12544 26444 19170 69263 19181 57296 69077 66997 26909 319183 12427 319182 106344 268930 72151 19367 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase 76308 71978 103468 19069 13006 70699 20843 234865 218914 208092 100088 66700 445007 110379 226849 225849 26931 21770 26932 380664 13001 19047 100039026 232987 14245 17222 68612 68999 668450 76816 66156 54130 18751 219103 217718 22142 59126 68475 69654 216965 18536 208518 381644 56455 236266 66977 13427 99100 214552 103733 13424 219072 104318 13726 51885 16328 57294 102920 233276 12442 71909 28135 17997 214444 68097 381318 74498 18221 226747 108000 12615 66570 382030 319149 625534 22151 319183 66468 238463 319182 74549 78658 228421 99412 73804 625328 98386 78303 319181 15270 26443 26444 19170 19181 57296 26413 69077 66997 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels 192775 240444 241794 16539 16502 16535 238076 16499 16497 16500 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination 68240 19891 319149 78303 319181 217716 319183 15270 319182 625328 225182 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose 66174 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function 17532 19047 MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins 13001 19047 100039026 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption 20537 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 64051 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events 22343 18749 19084 12326 12322 19087 12323 108058 242274 12325 26413 170483 108099 216963 19418 64011 241113 207565 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 21351 68981 20656 53379 12346 12631 18569 15526 12340 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression 252903 15007 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants 226849 225849 26931 21770 26932 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells 16533 140492 231252 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport 68015 17711 66414 67264 52892 67388 15526 67105 225887 12861 66052 17721 17722 380840 67680 226646 624814 17719 12862 544717 71803 100900 67003 100041785 66694 66821 66690 69702 380975 26940 66359 17449 52469 67044 17448 68198 66091 66416 66272 108755 75597 100042503 230075 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 12021 56420 80905 225182 68240 19891 78303 319181 15270 15204 269582 22427 19718 69745 69263 19687 26909 319183 18538 12427 319182 106344 269400 233826 72151 71711 268465 19367 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 16476 56406 15400 15410 22658 22632 103889 17749 15407 100043714 19401 625328 104625 58184 78303 319181 15412 15270 67710 14056 319149 245688 319183 319182 15399 16475 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling 17242 11682 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions 110135 14161 12322 12988 26372 12323 108058 99571 109905 12325 26413 11774 26395 26396 54519 109689 78781 11610 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants 14366 14368 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 12325 26413 19418 12322 12323 108058 242274 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 26416 107607 18439 12362 66824 67955 383619 16179 192656 16396 11797 332579 11796 68652 12366 66589 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs 19766 71966 17874 446099 69721 56480 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis 233833 192119 12047 433759 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants 19247 14255 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines 14056 319149 245688 208043 52690 225888 11569 73251 64707 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis 252903 11766 17113 14533 109689 72685 75612 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine 107146 435528 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway 233833 19056 14686 225600 14366 22418 14368 12387 18587 12322 14688 14704 21415 14696 14693 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation 12229 19056 229709 58194 19696 18037 26443 18751 26444 19170 19181 17060 20866 269717 57296 69077 66997 234779 18708 12234 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM 98053 67710 17749 100043714 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 21770 270198 18749 18639 18640 170768 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity 17128 26413 22284 433759 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels 72258 52150 16526 16530 16528 223604 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 54721 26413 19247 26396 16451 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions 12737 56217 71908 12738 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases 20202 241275 26413 26416 75669 13058 23988 13057 19354 18751 224480 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability 11651 227743 23797 12387 56716 228775 11652 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 50798 19025 66174 67422 18010 26938 54613 50877 57170 14583 69080 19703 234730 245847 56174 24060 20442 381903 20443 20440 20447 208624 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism 107146 243382 15108 12040 12908 11992 12041 227095 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 264064 333639 225164 15184 56438 433759 19165 15208 11491 16449 76580 51813 100039623 16450 100042305 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase 100043508 14228 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations 74653 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) 16163 16476 17132 241915 53314 20230 50794 333639 12151 15184 22632 12418 433759 245688 17283 234366 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 17711 66419 50529 100040519 66230 74600 66242 94067 64656 68836 66845 94065 108853 57312 17720 68572 66121 17721 17722 66258 18120 14548 56280 27393 17719 69956 56284 353242 118451 67681 17705 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia 233833 239789 21781 57441 218630 17863 622408 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes 17128 59092 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE 12651 237928 14245 75320 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic 76877 17155 54399 67542 72318 97484 16834 67474 76332 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs 12367 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion 13006 20843 218914 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling 19247 14178 67112 327826 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm 103468 19069 70699 13684 234865 445007 64340 233073 53817 110379 225160 386612 73666 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency 69065 67204 26905 228775 17872 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs 103468 19069 445007 70699 234865 110379 101739 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants 16590 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation 12325 24046 12322 12323 20273 108058 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia 14058 14071 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape 209357 75316 21429 17749 100043714 625328 13872 23894 319149 78303 106298 66467 319181 319183 15270 319182 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 12571 12578 IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex 66589 67245 16179 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers 14377 625328 433759 66055 12006 78303 319181 15270 17927 22083 17928 234366 70802 228880 11538 68981 106795 384091 22778 666609 101631 20833 27967 12387 68479 21423 18534 18104 67959 71389 319149 16002 245688 241128 319183 319182 20646 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 11806 15439 HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC 74182 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 56438 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 27370 16341 13685 629957 100039316 100038991 666899 66481 225058 100042986 67204 625646 26905 100042740 13667 209354 67891 67248 75705 13684 666669 27207 633683 432502 226982 19989 19899 19934 27979 18458 75617 56347 57294 223691 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification 67075 58205 16451 56438 226144 26443 26444 19170 76580 19181 20014 13001 57296 103963 69077 66997 108099 100039026 68292 241113 244373 69038 13135 12234 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration 11848 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K 14388 12064 18708 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins 80297 24046 20740 16728 11733 20741 20273 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle 22284 53382 216963 56324 14270 20740 18708 17920 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis 229709 110891 20541 12322 67972 12323 11941 108058 12325 20866 269717 21954 11928 11931 11933 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling 100041766 23988 11793 54644 56480 230073 74153 16396 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation 110135 14161 20720 14061 99571 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 73724 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis 78923 29873 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation 15234 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 56371 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery 98053 67710 13716 17749 100043714 20833 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 242705 21781 13557 211586 12571 12447 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade 19247 320207 14726 106722 30955 234779 11848 19354 18708 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) 387513 83771 387356 110326 574417 210198 387512 387347 57253 57254 387355 387342 387349 387616 387353 387515 353148 242425 353165 387348 14823 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation 14621 118454 14616 17920 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex 17222 68612 68999 56371 26443 66634 625328 668450 26444 66156 19170 19181 57296 319149 69077 78303 66997 319181 319183 15270 319182 57441 18392 18393 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 264064 17128 26413 21781 51813 211586 17283 433759 12579 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 54721 19247 26395 16451 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat 98053 67710 17749 100043714 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 12578 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events 26416 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere 22427 68240 19891 57321 21750 18538 69745 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency 21452 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication 226153 74528 50776 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation 11772 11771 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis 12229 245880 12502 17909 17918 330319 105855 22376 12928 242687 330662 17886 26413 14083 68089 66713 329165 74117 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 17001 72303 56448 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants 11682 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA 67065 19766 19090 218832 72162 70408 71966 17874 17749 214763 100043714 69721 12387 383619 446099 22040 56480 268857 20821 67005 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors 14688 14704 14696 14693 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins 21781 11651 211586 56455 68097 23797 11652 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 12064 SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 12571 12578 TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation 56438 66855 67895 28146 17705 74776 225363 14852 27979 56347 223691 16341 17711 13685 17721 17722 17719 67891 666669 633683 432502 19989 19899 19934 75617 57294 27370 629957 100039316 233870 100038991 666899 105148 66481 225058 70560 230577 224805 70120 67417 100042986 625646 100042740 67248 217337 27207 27058 22321 353172 66590 107271 110960 68098 67160 226982 57743 66419 50529 100040519 66230 74600 66242 94067 64656 68836 66845 94065 57312 108853 68572 17720 66121 66258 18120 14548 56280 27393 69956 13722 56284 353242 118451 67204 67681 26905 75452 66399 13667 209354 75705 13684 100041766 26443 26444 19170 19181 57296 69077 66997 67674 18458 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants 14255 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling 18673 12988 26372 19047 114715 114716 26403 18015 101809 11610 110135 14161 12322 12323 99571 108058 109905 12325 17532 26413 26395 11774 26396 63953 54519 109689 78781 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 103468 19247 19069 16171 70699 257630 107607 234865 230398 16451 170743 16179 192656 54721 445007 20390 68652 75669 66589 15007 110379 56480 230073 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate 67422 57170 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 14184 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes 15926 17436 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin 17128 26413 11479 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer 17128 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression 21679 21678 21388 15257 18091 21677 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling 16185 16451 16183 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28253 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis 67054 231327 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport 58176 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer 17128 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 17128 100038891 13819 18999 53417 620395 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization 19294 71740 58235 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans 16779 16773 228357 16410 17180 329278 21808 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis 60510 58194 12502 13858 17113 56324 14366 22418 13649 108679 20980 12402 233489 26895 26894 11839 238055 16197 109689 20508 11772 54609 11771 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation 72416 104444 71701 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors 19222 19217 19218 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis 13072 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 100041766 14469 17075 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development 26416 17918 11886 12558 105148 69675 11891 433759 16590 12047 13190 13722 17342 108664 11694 11964 11652 233833 192119 21425 20431 13612 12387 12578 26413 68292 23797 21415 22771 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling 21933 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 14178 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants 13380 84035 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS 12229 16451 170743 14815 56438 433759 15353 54721 99982 11928 234779 11931 56480 11933 234366 19766 58194 58861 14228 18391 57261 16177 17060 100043508 12846 245688 107392 50724 11772 60406 11771 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly 106795 22778 101631 14377 625328 433759 18534 319149 245688 78303 319181 319183 15270 319182 234366 70802 228880 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants 12539 59079 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation 27370 16341 13685 629957 100039316 100038991 666899 66481 225058 100042986 67204 625646 26905 100042740 13667 209354 67891 67248 75705 13684 666669 27207 633683 432502 226982 19989 19899 19934 27979 18458 75617 56347 57294 223691 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes 21351 14381 21881 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 16590 22632 13649 70472 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification 108664 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol 27370 109075 78394 216987 208366 629957 66583 27993 67676 100039316 67205 67053 100038991 72544 27966 59028 100608 18572 666899 66481 225058 100042986 625646 100042740 67248 68533 27207 24128 67891 30877 666669 229504 67045 66164 69072 53414 633683 432502 19989 223499 213895 50911 19899 100041622 55989 72554 69639 19934 104318 622491 75617 72662 234374 57294 227715 73674 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling 68799 19247 114873 20564 17909 330662 319713 14083 22253 13176 20562 244058 22068 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants 14255 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding 22142 14675 13001 24128 16553 55946 14688 22151 100039026 67466 238463 14704 14696 12447 14693 30838 20698 12468 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 104318 16328 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 19718 209357 67710 17749 100043714 57905 69745 56438 13194 13872 69263 68240 19687 19891 23894 66467 18538 106344 67439 72151 252870 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions 12934 80297 71653 20740 13649 11733 53870 13001 26413 26395 26396 56705 24046 100039026 16410 16728 19684 11772 20741 11771 20273 DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME 107146 71279 71773 11486 269823 14871 94215 18979 22436 233801 14598 436059 28253 22236 15483 75894 72303 435528 56448 18534 272428 552899 20860 18102 269346 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 228421 226849 225849 26931 21770 26932 68097 73804 381318 18221 19047 232987 226747 108000 103468 12615 234865 66570 216965 625534 445007 56455 66977 13427 66468 110379 13424 57294 102920 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 22151 238463 22142 12468 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression 319149 78303 319181 319183 75316 15270 319182 625328 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer 12402 14388 11839 12539 13649 18708 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants 11682 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 16590 18708 CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic 76308 11651 56438 71978 50496 68240 19891 15366 103468 19718 19069 13006 70699 20843 234865 69745 100043858 12580 218914 208092 19687 100088 66700 445007 12537 110379 226849 225849 26931 21770 26932 629959 380664 13001 19047 100039026 232987 14235 14245 17222 68612 68999 56371 668450 76816 66156 54130 18751 219103 12578 217718 22142 59126 68475 69654 216965 18536 208518 381644 56455 236266 66977 13427 99100 214552 103733 23797 13424 219072 16475 104318 13726 12234 51885 16328 57294 102920 233276 12442 71909 28135 17997 214444 68097 381318 74498 18221 57441 226747 18392 18393 11652 108000 21664 12615 66570 382030 242705 319149 625534 22151 319183 66468 238463 319182 268930 12447 74549 78658 18969 228421 99412 21781 13557 211586 22171 73804 625328 433759 20459 98386 78303 319181 15270 17865 26443 66634 30949 26444 12544 19170 69270 272551 69263 19181 57296 26413 69077 66997 12571 18538 12427 106344 72151 12579 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA 103468 19069 445007 70699 13684 234865 110379 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema 58992 16621 14061 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing 71514 20459 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) 19247 14388 12064 18708 12568 327826 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 17222 68612 68999 56371 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 12447 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 170736 21754 109711 57342 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) 22427 19718 12021 69745 80905 225182 69263 68240 19687 19891 26909 18538 269400 233826 106344 71711 72151 268465 19367 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 264064 56406 20249 68801 216154 170826 625328 234959 14311 51813 78303 319181 11770 67800 15270 70208 23945 21664 14245 23989 12568 67279 319149 319183 319182 16475 11520 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 17060 12402 19247 16185 16451 16183 12981 21682 12928 18708 12982 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling 11839 13649 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 12387 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle 214804 110279 105855 84004 223254 242687 404710 104445 19418 277360 241275 245880 76117 20401 22376 66898 71544 544963 67299 11352 213783 14270 117600 94190 225358 219140 26934 59079 380664 330662 16709 16449 98386 216963 239027 56419 212285 18708 70497 19349 224480 320795 109333 330319 13058 13057 213498 195727 442801 226751 329165 13726 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping 16476 241275 13057 22418 14369 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO 109689 57810 319757 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis 140474 20442 20443 17829 20440 20447 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions 74326 227743 75956 214763 71951 66055 20970 68816 68879 75669 14735 22083 56716 17395 14734 67418 384091 54633 666609 68219 98053 67710 18571 57905 68479 66642 14061 15569 319149 16834 319183 60321 319182 11806 17713 15382 17749 100043714 14104 78303 319181 64340 233073 68981 19766 192292 54196 17087 53379 21898 27967 12387 12259 12322 70616 12323 108058 216965 12325 67959 100040603 67439 19899 20646 192159 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation 22030 68652 107607 71966 66589 69721 59025 16179 192656 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer 16476 14025 56438 19084 433759 54721 12047 215114 17246 18148 268980 18708 11682 327826 16367 69162 14235 70297 672511 59069 17886 26413 13191 14939 67160 18646 54167 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases 16476 26413 26416 21770 17260 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription 21679 21678 21677 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle 26934 84004 11854 27984 380664 66871 98386 109711 18844 56419 18708 70497 13726 19349 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling 319713 14083 13176 330662 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste 387513 83771 110326 574417 387347 57253 57254 387355 387342 387349 546729 387616 387353 387515 353148 14688 353165 387348 68667 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 53945 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements 434178 625328 237758 433759 319149 245688 78303 319181 319183 15270 319182 74522 243834 234366 233060 75339 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation 18207 78303 57321 319181 319183 21750 15270 319182 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors 27370 19056 629957 100039316 14026 100038991 18749 666899 56438 66481 225058 19087 100042986 16825 625646 100042740 67252 67248 27207 11352 225363 67031 16870 17690 20562 14270 15399 12830 117600 14852 11848 13176 238276 67891 20564 666669 26443 26444 19170 633683 19181 57296 69077 66997 432502 19989 19899 19934 18458 75617 57294 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway 21351 14381 74637 232449 66681 21881 66646 TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling 19766 22030 100041766 21926 432940 11491 66552 76580 18201 11797 73218 106025 21937 11796 68652 56480 22195 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 319944 209357 98053 67710 17749 20926 100043714 93736 20833 70122 66464 68776 99730 13872 23894 226182 66467 24074 13716 22083 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A 17222 68612 68999 668450 66156 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 14270 117600 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora 105193 53412 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 14257 333639 15208 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions 192897 16779 20649 24051 20648 20391 24052 20650 20970 13527 60409 16651 12305 268534 16773 109711 16410 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation 18016 12229 245880 12502 17909 17918 330319 12631 105855 22376 12928 242687 330662 17886 26413 14083 68089 66713 329165 74117 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 12502 100041766 216150 26443 26444 19170 192656 19181 57296 69077 66997 68652 66589 18708 12234 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs 12631 77579 11848 17886 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions 330222 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 16476 241915 12151 15184 12418 433759 26413 14056 99982 245688 83409 13653 56716 234366 20613 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling 12402 26413 19247 14170 83379 327826 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors 11444 11447 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling 233833 20249 67484 268903 11813 11816 104263 18534 99982 14104 11812 16204 218214 22236 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs 109905 26413 26416 26395 26396 19762 12928 327826 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 74182 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) 22427 68240 19718 19891 12021 26909 106344 72151 225182 19367 69263 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria 68097 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis 26413 13806 672511 71514 13035 233405 108664 12721 19349 18126 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation 22030 230398 56480 230073 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin 13006 20843 74549 218914 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility 109905 15234 67299 14388 16779 14083 16773 12928 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins 109791 11813 11814 11816 67442 71951 20970 238055 69568 14735 11806 11807 11808 14734 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle 17449 17448 71803 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins 72090 67464 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle 26934 110279 11464 59079 84004 11848 223254 16709 66087 404710 98386 19418 239027 56419 212285 18708 12261 277360 320795 109333 19299 263803 208846 13830 69668 270163 71544 21763 213498 207212 442801 117600 94190 54411 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 13001 319974 241915 100039026 12151 66923 12418 56353 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs 320795 109333 263803 11835 11848 625328 17886 99982 319149 78303 319181 319183 15270 77579 319182 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization 68680 14311 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen 72017 320635 12346 12349 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling 18708 192176 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 19247 270152 12523 20970 83995 16728 16410 11931 11933 18708 17075 21933 18613 21687 11602 26570 50934 14061 20540 16409 80879 20737 66053 238055 20344 18106 12481 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival 16179 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 14381 21351 50493 15926 12013 56438 26570 26443 17436 26444 19170 19181 57296 18104 71389 69077 11839 66997 21881 12234 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins 103468 18854 19069 445007 70699 17246 234865 110379 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response 24014 246728 230073 192176 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium 53413 53869 18764 SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection 27370 56217 15382 629957 100039316 19035 170743 66101 66481 225058 16396 20442 20390 20443 75669 20440 18148 56480 20447 12362 66824 27207 633683 228005 208092 17128 66700 14376 230073 75617 667370 57294 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 57296 69077 66997 56438 26443 26444 19170 12234 19181 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism 20442 20443 70484 54371 54613 53625 75612 15212 56386 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport 67473 67582 18400 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 19247 384783 320207 12064 13649 15234 16590 14388 11839 14178 67112 14170 30955 14255 83379 268980 19354 18708 327826 16367 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs 75964 67091 74030 68365 76308 11651 14567 72433 211922 68328 76954 11891 69440 229541 72121 60409 320714 78232 216131 245886 19349 11652 56382 23797 19345 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 20613 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression 14815 13819 20459 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases 75409 386750 245450 272381 239250 327814 68507 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition 12442 71909 28135 17997 214444 629959 56438 71978 15366 108000 17865 14235 21664 56371 76816 26443 26444 54130 30949 219103 19170 22142 68475 19181 69654 18536 57296 208518 381644 69077 56455 66997 12537 236266 13427 99100 12427 214552 103733 13424 219072 268930 16475 104318 51885 12234 233276 16328 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters 15278 208595 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass 19718 69745 56438 80905 13194 69263 68240 19687 19891 68098 22210 18538 106344 72151 56210 71890 74153 22224 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors 11444 11447 231252 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions 264064 17087 21898 216154 80509 230398 16451 170743 23989 56438 234959 54721 66999 67279 71951 20970 51813 14735 70208 246728 230073 14734 SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes 329954 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement 12552 16451 12387 26443 26444 330662 19170 19181 11797 54721 57296 69077 66997 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling 13685 75705 83409 13684 56716 67605 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling 320139 19247 19249 19255 12362 56480 19256 16182 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 14312 333639 12387 26443 26444 19170 16449 19181 17128 57296 69077 66997 21679 17246 21678 21415 21677 11906 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 16476 19373 233833 19374 18749 26443 26444 225724 19170 18612 19181 57296 69077 66997 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 13001 19047 12952 100039026 104318 12568 UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle 11847 67824 109900 217214 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 13521 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones 16325 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer 19247 384783 11651 227743 16590 17246 14255 14170 83379 268980 18708 56716 67605 327826 11652 16367 320207 12064 13649 15234 14388 11839 14178 67112 23797 30955 19354 22084 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly 233532 66578 12615 66570 56505 245688 78303 319181 319183 15270 319182 18148 102920 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE 99010 237625 225845 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) 57296 19056 69077 19696 66997 18037 26443 26444 18751 19170 12234 19181 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG 66461 74451 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 72303 56448 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity METHYLATION%REACTOME%R-HSA-156581.6 Methylation 232087 238505 12846 57344 67674 269378 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation 109905 12928 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 12578 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion 233081 14675 74205 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein 67075 103534 108687 269181 57437 69035 107895 20014 20442 103963 20443 14376 68292 20440 69038 208884 20447 13135 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation 11847 15108 234847 226153 15526 17705 17721 17722 66494 17448 624814 18293 269951 118451 74142 67003 230075 636544 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease 76007 110279 98053 67710 17749 100043714 14388 14184 14178 67112 67529 244373 18708 327826 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade 16476 19247 26416 21770 192656 11797 11796 26410 66589 17260 56480 19766 17087 21898 22030 107607 100041766 71966 69721 59025 16179 26413 26395 68652 12234 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer 26413 18708 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 22151 22142 12468 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 14688 14704 14696 14693 14678 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells 11839 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 13649 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) 17874 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation 228421 69162 19025 26934 68097 73804 54130 12340 69654 56444 252903 13036 13191 56455 56464 15001 13427 19141 110379 13424 16594 11772 19349 11771 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus 117150 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins 56417 110532 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor 19222 14688 14704 14696 14693 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle 26934 110279 223254 16709 404710 98386 104445 216963 19418 239027 56419 26403 212285 70497 18708 14269 19349 277360 208846 330319 14570 22376 13830 71544 544963 67299 66871 213498 213783 442801 14270 226751 117600 94190 225358 219140 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants 12539 59079 13649 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction 229709 72258 52150 16526 16530 16528 21954 66240 24046 11928 16535 15257 56461 11931 11933 20273 21388 18091 18159 110891 20541 12322 67972 12323 11941 108058 20866 12325 269717 223604 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence 16476 26416 241915 21781 13557 211586 12151 50932 12418 625328 26921 56702 14957 57321 78303 50708 319181 21750 17246 26408 15270 66403 233833 15364 17222 68612 68999 56371 100043858 668450 12580 66156 12578 26413 242705 14056 319149 245688 319183 12571 12427 319182 12447 12579 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange 22427 68240 19718 19891 12021 26909 233826 106344 72151 225182 19367 69263 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane 75669 67073 DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE 238505 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins 73711 22088 67123 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 12571 12578 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 100039623 18131 100042305 19165 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript 209357 23894 98053 67710 66467 13716 17749 100043714 20833 13872 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers 72057 14025 14377 625328 433759 66055 12006 78303 319181 15270 17927 22083 17928 234366 70802 228880 11538 68981 106795 384091 22778 666609 101631 20833 27967 12387 68479 21423 18534 18104 67959 71389 319149 16002 245688 241128 319183 66923 319182 20646 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK 72149 69008 12283 83409 108099 241113 56716 22084 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 14460 26443 625328 21423 26444 19170 16396 19181 57296 319149 69077 78303 66997 319181 319183 16825 15270 319182 17863 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage 109674 11717 76654 75894 11486 80914 TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI 68240 19687 19718 19891 18538 106344 56210 72151 71890 69263 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus 11651 23797 11652 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling 12325 18573 229709 18749 19084 12326 12322 207565 19087 12323 108058 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 20249 14104 268903 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis 11677 59045 76205 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway 20202 12229 17087 21898 20193 110135 17874 14161 26443 26444 19170 19181 99571 57296 69077 66997 15007 20333 57743 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol 103468 19069 445007 70699 234865 110379 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 14255 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 22027 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling 16476 22165 12229 19056 229709 100041766 216150 26443 26444 14126 19170 19181 26413 57296 69077 66997 68652 16428 66589 21682 234779 18708 12234 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 16476 12229 26416 21770 192656 26410 66589 17260 20202 17087 21898 22030 20193 107607 110135 71966 14161 17874 26940 69721 59025 67245 16179 99571 26413 26395 68652 12234 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism 78923 29873 15212 109685 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic 228421 76895 26934 76308 76932 69834 16552 224705 16580 68097 67511 73804 67023 70646 78304 72772 66913 16562 12340 76332 16565 76877 56444 75050 54399 67542 72318 97484 73296 70297 17113 54130 69654 17155 56382 13191 56455 16834 13427 20333 13424 67474 12121 16594 18475 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease 21351 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF 21826 19247 12829 18815 12835 12830 21828 12928 18708 18791 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle 12889 327814 68507 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding 226849 225849 26931 21770 26932 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling 54721 76527 16451 19152 16155 12367 242700 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation 72096 70511 16588 68043 239706 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane 226849 212398 225849 26931 21770 26932 12387 20890 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 216820 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling 11652 18576 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism 11813 18749 11814 11816 171504 238055 17777 11812 11806 11807 11772 56453 11808 11771 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN 12064 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 209357 23894 98053 67710 66467 17749 100043714 13872 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing 27370 109075 78394 216987 208366 15108 66181 629957 66583 27993 67676 100039316 67205 67053 245474 100038991 72544 27966 59028 100608 18572 666899 66481 225058 83485 100042986 625646 100042740 67248 66132 68626 52575 68533 27207 24128 67891 30877 666669 229504 67045 66164 69072 53414 633683 432502 67674 19989 223499 213895 50911 19899 100041622 55989 72554 69639 19934 98956 104318 622491 75617 72662 234374 57294 227715 73674 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system 319149 78303 319181 72461 319183 15270 319182 58992 16621 625328 12261 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 14058 14061 14071 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism 19141 22337 AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy 56455 68097 13427 66589 13424 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections 11651 56438 16396 234779 18148 103468 19069 70699 14228 234865 208092 66700 445007 107392 110379 230073 11772 667370 11771 19035 14815 11928 11931 11933 58194 58861 16177 16179 633683 66603 100043508 20014 66383 103963 68652 53975 14376 68292 15007 23797 69038 208884 20815 13135 75617 57294 27370 12229 19247 56217 629957 100039316 233870 230398 16451 170743 233405 66101 66481 57437 77573 225058 192656 107895 54721 71951 20442 20970 20390 20443 75669 66589 80743 20440 14735 56480 20447 105722 11652 14734 384091 666609 16171 67075 257630 107607 103534 108687 18391 269181 12362 57261 27207 66824 71732 69035 228005 17060 245688 50724 60406 15382 433759 15353 99982 234366 19766 17128 12846 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors 241915 69260 268903 12151 22658 13016 18148 12418 229615 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions 19247 14083 668101 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 109075 70640 75705 66583 13684 72544 104625 58184 18983 50911 27756 69639 18458 72662 227715 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors 21770 18639 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding 18207 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation 319944 209357 98053 67710 17749 100043714 66464 68776 99730 13872 23894 226182 66467 24074 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins 76007 18708 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 75316 17749 100043714 625328 433759 18432 319149 245688 78303 319181 319183 15270 319182 234366 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 16521 16513 242425 14688 16519 14704 14696 14693 16516 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock 382056 21425 56406 12952 268903 70461 19377 56438 26443 26444 12568 19170 19181 13001 57296 19047 69077 272322 66997 100039026 17260 12894 104318 12234 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 11677 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 110115 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors 16521 16513 242425 14688 16519 14704 14696 14693 16516 14678 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation 18573 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor 11863 13819 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine 56417 110532 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen 110135 14161 99571 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation 117150 69260 23988 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways 50493 13858 13035 71514 233405 12402 108664 12721 19349 17075 18126 58194 12527 13806 672511 100041766 56324 18571 12387 20980 26413 26395 26396 14469 64051 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN 57296 69077 12006 66997 68031 26443 26444 19170 19181 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD 71951 20970 29873 14735 14734 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance 66181 245474 17749 100043714 625328 105522 67857 68240 19891 208084 57321 78303 22589 319181 21750 15270 22427 19718 67710 20174 72107 108689 56505 69745 69263 19687 319183 18538 12427 319182 106344 269400 72151 18969 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling 12402 19247 11651 11352 19271 23797 14255 18708 11652 12988 16923 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD 12040 DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 22027 56453 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia 29806 100041766 13819 56438 26443 26444 19170 19181 57296 11863 69077 66997 53417 16475 DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 67422 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control 27370 629957 100039316 100038991 666899 56438 66481 66855 225058 100042986 625646 100042740 75452 67891 67248 100041766 666669 27207 26443 26444 19170 633683 19181 57296 68098 69077 432502 66997 19989 19899 19934 75617 57294 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function 12552 239096 12387 12564 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling 27370 18854 19247 629957 100039316 67781 230398 16451 23988 229900 66481 225058 54721 76500 14088 237211 230861 18148 103468 19069 16201 70699 234865 17750 12362 27207 192176 445007 110379 14469 246728 230073 16649 56417 20821 27979 74153 56347 20698 667370 223691 16341 226849 93679 67525 70110 54139 57444 67204 19255 26905 13653 16391 13684 214158 12322 12323 633683 108058 12325 26413 224762 27056 15007 24014 75617 57294 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 225058 633683 432502 100042986 19989 625646 100042740 19899 19934 75617 57294 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal 17314 75452 69090 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions 27370 56217 15382 629957 100039316 19035 170743 12362 66101 66824 27207 66481 225058 16396 633683 228005 17128 20390 18148 56480 230073 75617 667370 57294 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog 245866 81896 18749 56438 26443 19084 106633 26444 19087 19170 11491 16396 319757 57810 19181 70300 74126 57296 69077 66997 66573 226861 109689 12234 CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects 58802 18573 241489 16533 23984 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection 18439 13035 12362 66824 67955 18438 69146 12267 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly 57296 69077 66997 67151 53380 66537 26443 26444 19170 19181 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors 20202 22027 14319 238055 11801 11816 11806 15439 20288 71145 117158 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase 21781 11651 211586 629959 56438 20459 68240 19891 57441 18392 18393 11652 19718 13006 20843 17222 68612 68999 69745 56371 26443 66634 668450 12544 26444 66156 69270 218914 19170 272551 69263 19181 57296 19687 69077 66997 18538 12427 23797 106344 72151 12447 18969 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling 19116 19247 56438 12234 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling 11651 227743 53859 320207 26410 23797 30955 56716 18708 228775 11652 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events 12442 14235 629959 268930 108000 17865 HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism 107239 71761 243537 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants 16590 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases 107260 19671 14479 22284 17246 22217 74270 71472 269582 252870 217057 69641 30940 235323 327799 100683 319651 216825 56324 56505 319183 319182 230073 22333 11835 11797 11796 12006 78303 319181 77125 22335 68031 19766 22030 59025 26443 18970 26444 19170 19181 21812 57296 17128 69077 66997 12427 109689 22224 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS 140474 17829 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events 11652 18576 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis 11305 19299 11806 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation 16784 19247 26416 11651 18815 12988 11551 21808 22138 109711 234779 11537 320202 21922 320207 67059 11818 110135 18613 27359 14161 19039 71946 22388 12321 18755 74840 14061 192176 66866 14064 99571 14675 15234 104418 16002 14688 18441 14704 14696 331374 14693 11806 11848 269060 217480 12928 12512 14726 106722 18708 23945 22068 12527 12631 18751 14678 18407 109905 72017 26413 16000 19156 20344 14083 54519 109689 30955 19354 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) 16476 17222 68612 68999 56371 625328 100043858 668450 12580 66156 12578 26413 319149 78303 319181 319183 12571 12427 15270 319182 12579 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders 12326 433759 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines 56480 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 21351 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins 15234 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 12402 14388 12539 13649 18708 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane 67073 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling 226849 16201 14088 237211 67781 19255 67204 26905 18148 56417 20698 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function 227485 230738 12387 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling 13610 11651 13649 14678 12390 26413 11839 14688 14083 23797 14704 14696 268980 18708 14693 17393 11652 20698 17395 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL 18119 11479 23863 320202 12622 620395 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG 238505 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing 74326 15382 75956 17749 100043714 66055 64340 233073 53817 225160 386612 73666 68981 384091 666609 53379 54196 68219 98053 67710 27967 20630 68479 14105 70616 56194 24128 67959 20646 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport 13723 80879 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL 226849 19247 26416 225849 26931 238055 21770 26932 18613 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing 74326 75956 66101 66055 68816 68879 67418 384091 54633 666609 98053 67710 57905 68479 66642 228005 60321 15382 17749 100043714 64340 233073 53817 68981 53379 237859 27967 20630 76167 14105 76522 70616 230596 19134 70767 72654 56194 67959 244672 66053 18949 238831 77644 71715 78372 67439 209003 27756 67229 20646 70312 227707 192159 66618 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase 12846 17161 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 20650 13527 16651 16779 268534 20649 24051 16773 20648 20391 24052 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells 16779 16773 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants 14255 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 18970 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate 11761 216134 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 14178 67112 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade 16476 26416 21770 22030 107607 71966 17874 26940 69721 59025 67245 16179 192656 26413 26395 68652 66589 26410 17260 12234 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling 18708 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 19090 12021 108138 227525 75570 78303 56626 319181 56196 319183 15270 319182 15204 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 19349 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 67065 218832 70408 66653 17749 100043714 102209 75627 67005 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 12040 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism 238505 77697 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins 22427 103468 18854 241915 19069 13006 70699 20843 12151 234865 108138 22658 12418 22591 445007 110379 67711 67241 15204 67872 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease 26416 11651 18749 56438 19084 19087 16396 14598 319944 103468 19069 98053 70699 67710 234865 108138 18571 20833 73711 66464 68776 99730 14061 22088 67123 208092 100088 66700 445007 226182 24074 18107 13716 110379 230073 74153 11772 667370 11771 28084 229709 66999 19047 11928 11931 11933 18708 12502 14687 13806 58861 16179 633683 66603 100043508 20014 252903 66383 103963 68652 53975 14376 68292 15007 23797 69038 208884 19345 20815 13135 75617 57294 27370 19247 56217 629957 100039316 233870 100038991 230398 16451 170743 22418 233405 66481 14369 57437 77573 225058 192656 107895 54721 71951 20442 20970 20390 20443 75669 66589 80743 20440 14735 56480 20447 105722 11652 14734 384091 666609 16171 67075 257630 107607 103534 672511 108687 18439 269181 12362 27207 66824 71732 67955 69035 14688 14704 14696 231380 14693 16476 15382 13858 17909 17918 71514 12928 15353 330662 69146 12402 99982 14104 64340 233073 108664 12721 18438 19349 12267 18126 68981 19766 54196 17087 53379 21898 13684 100041766 17886 26413 26395 26396 18854 227743 234779 18148 56716 14228 107392 11806 19035 14815 13001 100039026 67891 12737 58194 12527 330319 666669 13057 27967 13649 16177 12259 70616 20980 216965 67959 56455 432502 100040603 13427 14083 19989 13424 19899 67439 64051 19934 329165 20646 12234 192159 12229 13479 74326 68097 75956 13035 105855 214763 666899 66101 217303 242687 22174 11491 234852 20168 66055 68816 100042986 68879 17069 625646 68089 100042740 230861 66713 22083 74117 17075 17395 67418 241275 213539 245880 54633 209357 68219 67248 56445 56324 18391 57261 22376 57905 23989 68479 66642 100732 13872 228005 17060 67279 15569 14056 319149 245688 66467 16834 319183 60321 319182 14469 246728 50724 16649 17713 60406 264064 50493 216154 80509 17749 100043714 433759 234959 23894 51813 78303 319181 101739 70208 234366 192292 12387 26443 26444 19170 12322 14678 12323 19181 108058 12325 57296 17128 69077 12846 66997 18458 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses 20390 19035 170743 12362 66101 66824 56480 230073 16396 667370 228005 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA 103468 19069 445007 70699 13684 234865 110379 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate 70484 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions 22088 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 71951 20970 29873 14735 14734 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT 791260 12846 17161 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer 21812 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy 16784 22333 67414 68097 93739 13819 170731 13001 83409 100039026 75669 66119 66589 22335 56486 11793 66169 56480 56716 22195 100041766 73711 22088 67123 208092 66700 56455 108099 13427 666468 241113 68118 51897 13424 67841 235040 22084 11520 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins 629114 11870 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 384091 243963 666609 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import 66821 68185 67264 100041835 22333 53375 15526 73078 67105 66119 66169 17713 100042179 100900 21855 636544 103172 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 75964 76895 67091 53413 74030 76308 76932 14567 69834 11651 224617 224705 53869 260302 67511 72433 67023 93739 70646 211922 78304 68328 72772 76954 66913 11891 19326 69440 70296 229541 72121 16334 68449 60409 320714 78232 216131 245886 56486 50907 75612 11801 73711 108679 22088 67123 208092 26895 66700 26894 110379 11806 11772 11771 28084 104015 210789 217615 218038 68938 74741 20528 11816 233489 16197 15439 73296 69162 12502 58194 17113 13649 20740 54130 17920 21987 20980 69654 29816 252903 11774 232946 56455 14319 108099 20661 13427 14533 117197 245638 23797 109689 13424 72685 19345 67474 104318 68365 68097 14366 22418 215474 207352 105522 74498 67857 66890 215114 68089 66713 74117 14269 20741 11652 80297 70297 56324 56382 13191 11839 16834 20333 22084 16594 228421 99412 26934 13858 16552 16580 17918 73804 16562 12340 76332 16565 56444 76877 12402 75050 54399 67542 72318 97484 14621 118454 14616 20288 71145 20508 19349 117158 54609 22027 60510 20202 11766 11733 17886 17155 238055 241113 12121 18475 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression 233833 17128 19401 17927 21423 17928 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism 20133 50493 75894 22171 11486 72090 54369 67054 635960 109674 76654 11717 22436 67464 14544 18102 80914 56520 231327 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling 57296 69077 66997 53859 26443 26444 19170 12234 19181 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres 22427 19718 66181 245474 20174 72107 108689 56505 69745 69263 105522 67857 68240 19687 19891 208084 57321 21750 18538 12427 269400 106344 72151 18969 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane 20014 103963 67075 58205 68292 16451 69038 13135 76580 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers 170756 110891 20541 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis 22427 19718 72107 108689 69745 69263 68240 19687 19891 57321 21750 18538 106344 72151 18969 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH 68240 19687 19718 19891 68098 18538 106344 72151 80905 69263 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion 73711 22088 67123 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling 100041835 17705 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade 16476 26416 21770 170743 192656 26410 66589 17260 17087 21898 22030 107607 71966 17874 26940 69721 59025 67245 16179 26413 26395 71398 68652 27056 12234 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing 13035 12362 69146 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions 192897 20970 60409 109711 16410 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane 109242 71909 28135 17997 214444 67161 53869 67590 52906 232987 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 104318 16328 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 26416 229709 11651 227743 27371 105855 18749 11848 12928 242687 330662 16410 18708 56716 11652 245880 14257 16542 13058 13057 12387 18751 228775 14083 23797 329165 20698 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters 20536 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS 27388 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation 16476 26413 234779 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins 103468 19069 445007 70699 234865 110379 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling 12402 26413 19247 14178 67112 327826 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins 20740 18810 12367 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases 14385 14377 105193 53412 14387 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production 14687 14688 14704 18749 14696 19084 14693 19087 14678 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse 77579 11848 17886 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 57913 12366 12362 12905 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 12468 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 72057 14025 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling 333639 16449 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling 27060 140494 66144 108664 242341 11964 54411 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation 12325 64011 12322 12323 108058 242274 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 14583 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events 208092 71951 66383 66700 20970 75669 14735 14734 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors 109791 11651 11428 67442 71951 20970 52466 22072 11761 14735 14734 54219 15926 227683 20509 54338 20751 20522 67426 68421 11806 11807 71365 11808 14276 11813 11814 11816 108156 21452 77697 18606 106564 269614 14104 67993 109672 238505 226518 230125 52710 72621 102570 107747 238055 14528 26363 330064 18563 100705 69568 216134 217707 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway 11797 332579 26416 11796 68652 12366 107607 66589 12362 16179 192656 16396 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB 228775 11652 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines 57296 18247 18104 69077 66997 26443 26444 19170 75986 19181 20810 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption 20537 81600 109791 100043686 67717 69656 14915 G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase 13557 12427 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins 15488 16922 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly 71909 109242 28135 53413 17997 56297 214444 207911 67161 68097 53869 18764 245866 71492 81896 67590 52906 106633 76411 12589 264134 319757 66061 57441 218630 622408 239789 17863 21781 232987 233833 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 236266 13427 99100 214552 103733 13424 219072 104318 16328 RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events 77974 12057 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin 22151 231093 237930 244071 320244 238328 22142 67269 226841 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease 76007 110279 14388 67529 244373 18708 327826 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis 13072 110115 15483 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 109821 14058 14071 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 67112 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking 66394 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 13612 68292 12558 69675 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events 380836 70701 12007 67075 233280 58176 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs 54325 68801 74205 106529 30963 170439 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs 68449 224617 53869 260302 93739 56486 19345 19326 22084 19349 70296 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding 14170 83379 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus 100039623 225164 16450 18131 100042305 13649 19165 76580 16449 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 56794 15488 12908 20524 17117 26378 56185 16922 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation 18293 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly 52469 67044 52892 67388 12862 66272 67105 100041785 66359 12861 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression 109075 70640 66583 72544 67204 26905 50911 69639 72662 227715 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 12539 59079 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins 103468 241915 19069 445007 70699 12151 234865 22658 110379 12418 55989 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs 233833 319149 78303 67710 319181 319183 15270 17749 319182 100043714 625328 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism 217593 12971 19193 110695 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex 68652 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation 56702 14957 50708 12367 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction 625328 225182 68240 19891 57321 22788 78303 12396 319181 21750 14726 100038891 15270 13006 140557 20843 12527 50878 217716 56739 77053 319149 319183 319182 18999 329954 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling 12933 12934 18845 22240 18844 12568 65254 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine 272428 107146 435528 233801 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 116939 67800 23945 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) 53945 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants 226849 225849 26931 21770 26932 12387 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 227095 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding 14688 110637 14704 14696 14809 14693 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling 16396 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction 77974 12057 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins 12057 30044 13603 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle 17222 68612 68999 56371 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 12234 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome 16476 26416 17087 21898 21770 22030 107607 71966 17874 170743 26940 69721 59025 67245 16179 192656 26413 26395 68652 66589 26410 17260 12234 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib 12539 59079 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex 68652 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity 58992 16621 12261 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors 11651 18996 228829 23797 11652 53325 29813 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK 213498 19418 207212 442801 277360 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking 14621 118454 14616 17920 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER 19718 209357 69745 56438 11546 13194 13872 69263 68240 19687 19891 23894 66467 18538 106344 72151 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints 12442 26416 12021 68097 381318 59092 56438 26374 225182 18221 68240 19891 17246 226747 18392 15204 18393 269582 108000 29813 22427 103468 19718 12615 234865 66570 228829 625534 445007 319183 66468 319182 110379 12447 268930 226849 228421 225849 26931 21770 26932 73804 19047 78303 319181 15270 232987 17222 68612 68999 668450 26443 66634 26444 66156 12544 19170 69263 19181 216965 57296 69077 56455 66997 66977 26909 13427 12427 106344 13424 72151 19367 12234 57294 102920 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription 209357 75316 21429 17749 100043714 625328 433759 13872 23894 319149 245688 78303 106298 66467 319181 319183 15270 319182 234366 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors 11551 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer 56438 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway 12325 18573 18749 19084 12326 12322 207565 19087 12323 108058 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion 233405 12721 19349 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic 228421 26934 76308 16552 16580 73804 67511 67023 72772 66913 16562 16565 75050 20333 16594 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology 26416 11651 22658 18749 56438 11891 19087 16334 16825 17342 11694 21425 67710 22410 20356 19215 11772 11771 12224 20528 16449 57810 15378 14573 66999 15396 20472 14048 15431 15412 15403 15904 16869 18510 18708 11964 327826 233833 12578 633683 68292 23797 20815 75617 57294 65254 27370 12933 19247 384783 12934 19056 18845 629957 140571 100039316 22240 100038991 20361 12555 12561 12386 105148 12558 66481 18209 225058 23792 54376 11488 246316 11652 27207 14388 11839 14178 18999 21415 22771 17863 19684 16476 21781 211586 17909 333639 17918 19041 15400 68668 15410 66203 103889 317653 15407 13819 66344 11848 22762 240633 13448 18772 70166 330662 22253 13176 108664 620395 22068 192119 54196 75705 20564 16162 12193 20431 13684 13612 12631 103988 11733 53870 17886 26413 26395 26396 15376 18012 18609 246086 19213 378435 18088 11886 19165 104625 58226 11479 58184 100039623 12622 11705 100042305 18983 16410 53417 17927 64058 17928 320202 18534 18119 23863 225363 67031 16870 17690 20562 15399 12830 14852 75605 12829 12835 109620 19401 69675 230753 227937 13001 16590 100039026 216963 100038891 14581 16694 66809 435273 16668 53622 406222 14247 77055 20613 215798 100041488 67891 16681 94187 58194 17196 16682 16691 67784 107656 666669 18858 16665 16666 13649 20740 17292 21380 213498 432502 14083 19989 18844 19899 16475 19934 14026 666899 19122 239556 12047 13839 100042986 319713 24046 13846 625646 68089 13845 100042740 270190 16728 66713 244058 74117 67252 623279 20741 17395 20273 68799 114873 80297 67248 71653 19699 16779 23989 12568 67279 14056 319149 56705 245688 11352 319183 17283 16773 319182 77579 14270 117600 16163 264064 17132 56406 241915 53314 20230 216154 80509 50794 170826 12151 15184 17749 22632 100043714 21926 12418 625328 433759 234959 51813 13190 78303 319181 13722 11770 15270 238276 17260 70208 234366 21388 18091 12387 26443 21423 26444 19170 13838 19181 13389 57296 17128 56184 69077 66997 21679 18458 21677 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 16590 18708 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis 264064 56406 94187 216154 80509 170826 12224 20528 21926 23989 230753 433759 234959 18534 66999 67279 17128 51813 245688 22410 11770 70208 234366 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport 228421 76895 26934 76308 16552 16580 68097 67511 73804 67023 72772 66913 16562 12340 16565 56444 75050 54130 69654 13191 56455 13427 20333 13424 12121 16594 18475 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis 66065 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis 226849 19247 26416 225849 26931 21770 26932 23984 58802 18573 241489 16533 22068 18438 18126 18439 18613 110891 20541 67972 11941 20866 269717 238055 14688 19222 14704 14696 14693 DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants 11682 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion 14675 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression 233833 192119 26416 20431 13612 17918 11886 12558 12387 69675 11891 433759 12578 12047 13190 68292 21415 108664 11964 11652 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis 50798 67422 14583 72157 319625 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters 12006 12387 21415 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated 226849 225849 26931 21770 26932 12387 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence 12571 12578 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease 12402 19247 76007 14255 18708 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation 26416 13190 20431 17918 12387 11891 11652 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT 77579 11848 17886 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids 97212 26922 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains 12502 19260 19271 12988 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed 223870 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 433759 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway 333639 18131 15184 433759 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome 57296 69077 66997 18749 56438 26443 26444 19170 12234 19181 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants 14255 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation 14170 83379 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 229709 21770 104112 18749 19084 19087 18639 11551 240444 16334 14104 74205 238276 21881 21351 233081 68465 14678 109905 14675 14688 108099 100705 238076 14704 14696 14693 16500 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation 11651 20751 18107 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 258763 258729 258769 258325 170639 258752 18365 258939 258961 258305 100038859 100043474 259035 16825 257917 258819 259075 259058 18310 258659 18314 258896 257883 258587 258352 258287 258580 258321 259036 259034 18324 258985 258267 258832 668825 18330 16870 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels 192775 241794 16539 16502 140492 58802 72258 52150 240444 16526 16530 16528 16533 16535 16519 140493 16516 16521 16513 242425 14688 223604 238076 14704 14696 14693 16499 16497 16500 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters 22784 230810 72002 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening 319149 78303 319181 319183 21429 15270 319182 625328 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer 21812 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade 19247 384783 228775 14388 16000 16002 75669 14178 67112 14170 14255 83379 18708 327826 11652 16367 18576 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 264064 333639 225164 15184 56438 433759 19165 15208 11491 16449 76580 51813 100039623 16450 100042305 CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT 19056 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 17001 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 14178 67112 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling 11352 67252 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency 26363 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors 14739 65086 13610 53978 14745 381810 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 66589 67245 16179 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs 19358 19359 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis 192119 53424 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) 20540 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling 19247 67112 327826 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS 21826 11504 66548 330267 207596 224697 223838 20356 18636 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events 67075 103534 108687 269181 57437 69035 107895 20014 20442 103963 20443 14376 68292 20440 69038 208884 20815 20447 13135 105722 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation 69082 225363 13494 14071 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 319149 78303 319181 319183 15270 319182 74522 625328 75339 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 76654 80914 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers 18854 384783 19247 11651 227743 18749 19084 19087 16334 83409 17246 54484 56716 252870 11652 117150 320207 228775 15234 14056 14388 245688 11839 14178 67112 22084 226849 16476 225849 229709 241915 26931 21770 26932 12151 15184 12418 433759 13001 18573 99982 16590 100039026 77125 15937 14255 14170 83379 68031 268980 14302 13653 18708 234366 207565 98432 67605 327826 20613 16367 233833 17874 12064 13649 26443 26444 12326 19170 12322 16179 12323 19181 108058 12325 57296 26413 69077 66997 23797 30955 19354 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death 19766 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 13649 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors 106795 22778 14377 625328 433759 18534 319149 245688 78303 319181 319183 15270 319182 234366 228880 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion 83485 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase 66240 16535 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane 16476 26416 21770 22030 107607 71966 17874 26940 69721 59025 67245 16179 192656 26413 26395 68652 66589 26410 17260 12234 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 209357 23894 98053 67710 66467 13716 17749 100043714 20833 13872 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes 27060 140494 66144 13058 13057 19354 108664 242341 11964 18126 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis 19766 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants 110135 14161 18673 12322 12988 12323 108058 99571 109905 12325 26413 26395 26396 54519 109689 26403 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes 59092 29813 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 14688 14704 18749 14696 19084 14693 19087 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants 26413 63953 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT 19056 14686 22419 11651 225600 106042 14366 22418 14368 14369 56438 360216 18587 20377 11652 100683 56505 22421 20890 84035 319149 22410 14688 319183 17283 319182 14704 14696 21415 14693 11772 11771 226849 212398 225849 26931 21770 26932 93840 11848 625328 433759 13001 12006 78303 319181 100039026 15270 68031 233833 208846 13016 12387 26443 26444 18751 19170 12322 192199 19181 73130 59036 57296 14160 13380 30930 69077 329252 66997 407821 20675 19354 12234 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol 271424 102954 217837 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling 77125 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC 13176 12367 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events 381489 18749 19084 19087 14607 23984 18573 241489 54409 215854 15565 93896 56089 22095 14687 14309 51801 239530 29863 14678 14608 76854 381853 26385 14688 19222 235036 19217 14704 109689 14696 14693 20287 13492 18576 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis 227102 241447 76893 74442 432628 70750 93898 20698 545975 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 22040 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades 20202 12229 17087 21898 20193 110135 54445 17874 14161 170743 99571 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 13001 100039026 12568 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription 17128 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction 19247 12928 18708 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling 12387 21415 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis 14385 18534 100043349 14377 13806 14120 18563 13807 14751 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins 20442 20443 14376 20440 20447 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle 67784 53382 269682 232339 93840 233877 380664 16709 244418 216197 11671 227937 18221 21927 19249 18708 14269 327826 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol 104015 16329 269180 16330 56727 54384 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 26416 12021 76367 23988 225182 13001 68240 19891 100039026 17246 15257 69181 319944 22427 19718 20833 66464 68776 12568 99730 69263 226182 108099 24074 26909 12427 241113 106344 72151 19367 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 13072 110115 11863 56050 13123 11864 13122 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 21781 211586 629959 12427 18538 12447 433759 17865 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins 11848 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription 76007 625328 433759 99982 78303 319181 20901 15270 13345 75339 20613 192173 56805 16601 18746 114142 13016 21423 26413 14056 319149 245688 319183 319182 15376 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery 103468 19069 445007 70699 234865 110379 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization 56217 76007 12555 16451 12561 12558 54721 20901 17246 15426 16201 14056 319149 245688 319183 319182 13858 19294 625328 433759 330662 18554 11797 13001 99982 78303 319181 100039026 15270 13345 75339 71740 20613 58235 233833 12552 192173 12554 12737 56805 16601 239857 18746 71908 114142 239096 12738 13016 227485 230738 12387 330222 26443 215654 21423 26444 11727 19170 12564 12563 19181 12560 20014 57296 26413 103963 69077 66997 14376 69038 15376 13135 53325 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer 17128 21812 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria 109900 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription 14939 333639 14128 15208 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function 22427 12021 26909 233826 225182 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation 109905 26413 26395 26396 83409 110135 54519 14161 109689 12988 99571 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis 234730 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 14170 83379 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases 72902 17384 18815 17228 13035 83995 12822 22072 16621 23948 17393 17395 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions 17161 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 17222 68612 68999 56371 668450 66156 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing 57394 16334 53413 67475 17918 11891 12876 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 18400 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 22784 230810 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 233833 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 107566 71279 243328 269346 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin 384783 19247 16367 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 12402 14388 12539 13649 18708 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity 11848 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine 246221 73748 27376 66071 12583 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response 213539 22791 103468 19069 70699 234865 15526 26413 68240 19891 445007 110379 219158 29810 18415 72630 56354 50497 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 17128 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 17772 75669 170749 54384 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK 26413 14459 13649 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism 103468 19069 70699 14377 21770 13806 234865 18749 103988 18639 18640 170768 18534 14385 100043349 445007 14120 18563 56421 110379 270198 13807 14751 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy 233870 80743 233405 71732 77573 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates 17001 CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization 72057 14025 14377 66262 66055 17927 22083 17928 70802 228880 11538 106795 384091 22778 666609 225876 101631 100683 216825 18602 27878 20174 228829 21427 56505 20833 109115 68479 217031 52690 66464 244694 71371 78656 208146 64707 18534 104263 74026 14056 18104 214572 71389 319149 277250 16002 245688 72341 241128 20591 319183 66923 107392 319182 242726 218214 15161 193796 225888 50724 73251 75605 60406 230233 208043 625328 15353 433759 269003 99982 12006 78303 319181 15270 69612 11569 234366 68981 27967 12387 21423 67959 70088 20646 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 11813 11814 11816 11806 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 27060 66144 56032 242341 101148 277854 230676 83409 110379 98402 108664 56716 71962 11964 319481 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 67065 218832 70408 20823 66653 71752 17749 66596 100043714 102209 75627 67005 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling 109905 20469 380711 18749 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system 18854 26416 320139 76527 11651 23988 19271 56438 14088 12981 234779 18148 16880 17161 103468 19069 70699 234865 17750 445007 14128 110379 17829 60504 230073 27979 74153 56347 667370 223691 16341 226849 21770 18414 93679 15526 54473 67525 19256 70110 54139 57444 16185 100038891 77125 16197 19255 16155 13653 18708 16182 16367 16164 19373 19374 16391 16178 71966 214158 17874 57914 69721 59025 16177 67245 242700 16179 633683 329244 16409 68652 224762 27056 19249 237313 50498 15007 12931 21682 23797 24014 12982 12234 75617 57294 27370 19116 19247 384783 629957 12346 100039316 16168 67781 230398 140806 16451 229900 13035 66481 12367 225058 11491 12988 192656 54721 76500 237211 66589 83995 230861 56480 20299 11652 17395 20297 21351 16171 16201 257630 107607 12362 27207 192176 17060 15234 319149 11352 14469 246728 16649 56417 20821 20698 16923 16163 16476 53314 21926 12928 12340 69146 60505 11797 12402 21937 24099 11796 26410 17260 67204 14255 26905 18126 22027 68981 20656 53379 16162 22030 16161 13684 53859 16160 16159 21942 100041766 12631 245527 19152 18569 57916 16992 326623 26443 26444 19170 12322 12323 19181 108058 12325 57296 26413 26395 69077 66997 16183 69583 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation 66447 69065 14598 14871 100042314 75475 76263 56615 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation 320207 30955 18708 50723 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors 213788 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development 18749 56438 19165 19087 58226 100039623 16825 100042305 16410 225363 67031 20356 16870 17690 20562 15399 12830 14852 11772 11771 12829 12835 13001 14573 100039026 216963 18708 327826 215798 67891 17196 58194 67784 18858 666669 13649 20740 633683 213498 432502 14083 19989 18844 19899 19934 75617 57294 65254 27370 12933 19247 384783 12934 19056 18845 629957 140571 100039316 14026 22240 100038991 20361 666899 19122 66481 239556 225058 13839 319713 100042986 24046 13846 13845 625646 68089 270190 100042740 16728 244058 66713 67252 74117 623279 20741 20273 17395 68799 114873 80297 71653 67248 19699 27207 12568 56705 14388 11352 16773 77579 14270 117600 19684 17909 11848 13448 330662 22253 13176 238276 22068 20564 12631 26443 11733 26444 53870 19170 13838 17886 19181 57296 26413 26395 69077 26396 66997 18458 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes 72017 320635 12346 12349 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system 77974 12057 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling 19247 16391 230398 16451 54721 70110 54139 76500 57444 27056 15007 14469 24014 246728 13653 56417 667370 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication 319149 78303 319181 319183 15270 319182 18392 18393 625328 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids 241447 330260 26938 13122 11886 17117 18749 269823 240753 101490 170460 20494 269180 14598 66190 271970 235293 67469 15483 13072 110115 19025 19299 15488 320207 66065 26459 631304 56185 228775 76205 67073 17764 15212 19215 12894 11806 11807 14421 545975 104015 18010 12908 22337 52538 26379 102247 230753 70568 74451 56305 16922 12651 17001 13001 66999 116939 237928 54325 19047 56018 17772 12891 11677 100039026 67800 68393 19141 75320 72482 20597 66586 212862 66461 239559 85031 18708 93898 23945 225845 28253 27388 66443 266692 74182 68682 76893 97212 72303 77582 56448 26457 106861 14245 17113 215456 99010 237625 106529 77219 240752 26378 17436 233552 100043508 56050 56794 19156 108099 19249 14200 30955 12408 56473 13479 68365 73724 19063 13123 104112 22239 11863 74442 68680 66569 75669 18979 16204 16592 14077 30963 78894 117150 11864 26922 20524 23989 56386 14593 223753 56360 67279 219135 74522 20698 11520 264064 50493 56406 171281 20249 74156 68801 216154 80509 170826 170749 432628 50877 59045 54384 234959 545260 14311 98386 51813 14104 74205 11770 70208 433323 170439 227102 100705 216820 76267 70750 56453 15356 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions 68682 227394 20521 13723 80879 75750 108115 101488 20502 27376 237831 58807 28253 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs 14255 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD 74126 57296 69077 66997 26443 26444 19170 19181 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis 19687 19718 18538 69745 106344 72151 69263 18969 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport 22333 170756 11640 22335 234847 18673 73078 12034 216001 215999 381038 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway 15378 192292 11835 22337 19401 26380 26379 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 54194 69556 56406 74322 17283 228829 69612 101739 208043 15161 217031 208146 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis 29873 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway 18970 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation 228421 226849 225849 26931 21770 26932 68097 73804 381318 18221 19047 232987 226747 108000 103468 12615 234865 66570 217718 59126 216965 625534 445007 56455 66977 13427 66468 110379 13424 57294 102920 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly 238055 17777 11813 11814 11816 11806 11807 11808 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs 12021 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis 233833 239789 21781 57441 218630 17863 622408 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism 20494 19299 56050 15488 13123 13122 17117 26459 16204 28253 170460 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions 76007 12555 16451 12561 12558 54721 20901 17246 15426 16201 14056 319149 245688 319183 319182 13858 19294 625328 433759 330662 18554 11797 13001 99982 78303 319181 100039026 15270 13345 75339 71740 20613 58235 233833 12552 192173 12554 56805 16601 239857 18746 114142 239096 13016 227485 230738 12387 26443 215654 21423 26444 11727 19170 12564 12563 19181 12560 20014 57296 26413 103963 69077 66997 14376 69038 15376 13135 53325 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 106564 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 57296 69077 66997 108099 241113 244373 226144 26443 26444 19170 19181 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 226849 212398 225849 26931 21770 26932 13016 12387 56438 26443 360216 433759 26444 19170 19181 57296 69077 66997 21415 12234 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) 22589 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT 16590 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events 56533 14687 14688 14704 14696 18751 14693 18755 11551 14678 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 235293 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors 57260 58861 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol 104015 114875 16330 217837 234779 320404 18798 269615 18799 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity 12402 15234 58194 13858 56324 19255 19271 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation 26876 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions 114873 13176 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking 94221 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins 17919 14688 53869 14704 18749 14696 19084 14693 19087 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins 11870 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination 78303 57321 319181 319183 21750 15270 319182 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway 56480 230073 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants 114715 114716 18015 101809 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 71398 27056 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) 18708 16367 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin 384783 14388 320207 30955 234779 18708 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII 12402 14388 12539 13649 18708 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network 70297 76932 69834 224705 17113 70646 78304 76332 56382 67542 97484 16834 73296 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling 19047 14479 20901 170749 17872 21812 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 110078 110095 77559 19309 14387 72157 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 233833 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose 69080 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity 12571 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins 12873 13809 11421 17228 13035 56373 16790 76703 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development 17132 17128 26413 212712 11835 68527 56275 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells 18609 246086 19213 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses 18749 214579 19084 12293 12287 19087 54376 19418 17246 17161 791260 11444 14688 14704 14696 14693 11771 216456 12889 327814 68507 216963 238276 207565 20508 14660 16519 110637 14658 22343 14809 328699 14645 16516 18751 12326 14402 17920 12322 14397 14678 12323 242274 108058 11447 12325 170483 26413 16521 16513 12846 242425 14409 108099 14408 231252 64011 241113 110304 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 13001 19047 100039026 SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste 21906 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein 103468 19069 445007 70699 234865 110379 103988 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 382056 20656 56406 170826 70461 226153 26379 12326 50776 15278 208595 269951 17260 15161 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape 319944 209357 98053 67710 17749 100043714 66464 68776 99730 13872 23894 226182 66467 24074 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 12934 26413 71653 16728 11772 19684 11771 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport 99412 80297 76308 68097 67511 20740 66913 54130 11733 12340 76332 74498 69654 56444 54399 16334 67542 13191 97484 56455 16834 13427 13424 20741 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade 110135 14161 109821 14058 14061 105722 14071 99571 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization 19041 68668 66203 317653 109620 66344 240633 18772 70166 227937 16694 66809 435273 16668 64058 53622 406222 77055 100041488 16681 16682 16691 107656 16665 16666 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds 13072 110115 72303 56448 26876 13123 11864 13122 18984 631304 55990 66112 100043508 11863 56050 64385 13849 17161 436059 74134 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants 110135 14161 12322 12988 12323 108058 99571 109905 12325 26413 26395 26396 54519 109689 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma 11651 14688 320207 14704 23797 30955 14696 11848 14693 11652 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation 209357 23894 98053 67710 66467 13716 17749 100043714 20833 13872 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators 667277 12944 12259 12260 239447 12262 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER 66890 217615 11839 20333 50907 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation 17711 66419 50529 100040519 233870 66230 74600 66242 94067 64656 68836 66845 94065 108853 57312 17720 68572 66121 17721 17722 66258 18120 14548 56280 27393 17719 69956 56284 353242 118451 67681 66399 17705 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome 12326 433759 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere 22589 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) 54721 19247 100041766 16451 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 15926 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids 56406 20249 13123 13122 22337 17117 59045 170460 20494 98386 14104 11677 19141 16204 235293 28253 15483 13072 110115 19299 15488 66065 26459 14593 170439 76205 56050 100705 17764 56453 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins 17222 68612 68999 56371 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 12234 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 14688 14704 14696 14693 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism 66194 216456 14645 14660 69051 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines 107747 20509 52466 14276 108156 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism 11486 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 13521 108652 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 72303 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins 228421 226849 225849 26931 21770 14026 26932 68097 73804 381318 11848 18221 19047 56419 232987 226747 108000 103468 320271 208846 12615 234865 66570 11854 216965 625534 445007 56455 66977 13427 66468 110379 14270 13424 57294 102920 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes 71909 28135 17997 214444 76816 54130 219103 22142 68475 69654 18536 208518 381644 56455 12537 236266 13427 99100 214552 103733 13424 219072 104318 51885 233276 16328 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 17749 100043714 56438 68240 19891 23894 252870 19718 209357 67710 57905 69745 108679 13194 13872 69263 19687 26895 26894 66467 18538 13716 106344 67439 72151 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 109791 11813 11814 11816 67442 71951 20970 238055 14735 11806 11807 11808 14734 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations 246179 24060 243853 67843 75847 228366 74653 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle 26934 110279 75409 59079 105855 84004 380664 242687 16449 98386 104445 216963 386750 56419 212285 70497 18708 19349 224480 277360 241275 76117 13058 13057 66898 71544 195727 11352 14270 329165 94190 13726 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL 13001 100039026 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis 16476 99412 20656 12261 12568 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 11797 24099 11796 22030 53859 16992 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 22589 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production 21937 21926 18201 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway 68652 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization 56217 76007 12555 16451 12561 12558 54721 20901 17246 109711 12821 15426 16201 192176 14056 319149 245688 319183 319182 192897 13858 19294 18810 625328 433759 330662 18554 11797 13001 99982 78303 319181 100039026 15270 16202 57342 13345 75339 71740 20613 58235 233833 170736 12552 192173 12554 12737 56805 74202 16601 239857 18746 71908 114142 21754 239096 12738 13016 227485 230738 12387 330222 26443 215654 21423 26444 11727 19170 12564 12563 19181 12560 20014 57296 26413 103963 69077 66997 14376 69038 15376 13135 53325 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters 13521 320718 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 12325 12326 12322 12323 108058 242274 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA 214579 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling 16178 16160 16159 16451 21926 16177 54721 21937 14128 12981 16155 20299 20297 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 264064 333639 225164 15184 56438 433759 19165 15208 11491 16449 76580 51813 100039623 16450 100042305 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism 76654 22436 72090 67464 14544 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways 16476 12229 26416 13479 229709 17909 17918 105855 22418 13035 18749 14369 19084 12928 242687 330662 19087 69146 11491 68089 14598 234779 66713 74117 18438 12267 241275 245880 12502 14687 58861 330319 18439 12362 13057 66824 22376 67955 14678 17886 26413 14688 14083 14704 14696 14693 329165 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) 20656 11651 74142 15526 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK 68240 19687 19718 19891 18538 106344 56210 72151 71890 69263 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis 98386 14593 235293 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import 19299 20524 103737 66437 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions 11733 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division 13006 20843 74549 218914 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 50493 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) 26416 384783 21770 211770 11848 12928 12568 109905 26413 26395 26396 21990 15904 17260 19762 13653 18708 327826 11772 11771 16367 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling 16476 19247 16451 13819 56438 625328 12988 76580 13001 78303 319181 100039026 15270 244373 233833 12502 67075 58205 57261 12387 226144 26443 26444 19170 19181 20014 57296 14056 103963 319149 69077 245688 66997 108099 21679 319183 21678 68292 319182 241113 69038 21415 21677 13135 12234 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body 54219 68421 21452 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation 108138 101739 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade 19152 58992 16621 109821 20720 14058 14061 14071 71951 20970 20597 14735 105722 14734 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules 20168 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes 27370 16341 226849 629957 100039316 67781 16451 23988 66481 225058 14088 237211 67204 19255 26905 230861 18148 103468 19069 16201 70699 13684 234865 12362 27207 192176 633683 445007 110379 14469 24014 246728 230073 16649 56417 27979 74153 75617 56347 20698 667370 57294 223691 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 29806 100041766 13819 56438 26443 26444 19170 19181 57296 69077 66997 53417 16475 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 209357 98053 67710 17749 20926 100043714 93736 20833 70122 13872 23894 66467 13716 22083 XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation 18749 19084 19087 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events 18749 19084 12326 12322 19087 12323 108058 242274 12325 26413 108099 216963 19418 64011 241113 207565 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint 22427 19718 12021 225182 69263 68240 19891 78303 319181 26909 319183 12427 15270 319182 106344 72151 15204 19367 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway 67870 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis 252903 15007 108664 11772 11771 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 12021 14048 78303 319181 319183 15270 319182 193796 15204 14050 11785 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) 12057 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm 16869 18510 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy 22333 67414 100041766 170731 13001 100039026 66119 66589 22335 11793 66169 56480 22195 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling 207911 11651 18749 19084 19087 54409 215854 15565 93896 74191 226304 626596 56089 13610 51801 320207 19049 387512 239530 67792 14061 18755 29863 433292 14608 14064 76854 65086 381853 57260 233080 26385 213788 106512 104418 21334 19222 235036 14427 30044 19217 12424 19218 18441 30878 18442 67839 246691 14823 331374 171469 14745 20287 16963 13603 381810 227326 225642 14739 68039 381489 229709 56533 12854 14459 21770 19735 387356 78134 18155 53978 210198 58182 12061 12062 269060 217480 14607 18708 23945 14687 58861 12057 13649 18751 213498 19156 207212 442801 23797 30955 109689 12229 19056 14686 26361 11551 19418 11652 20311 277360 20297 20296 22095 14309 12568 14675 14688 14704 14696 14693 13492 13491 18576 83771 574417 387347 57253 57254 387355 11848 387342 387349 387616 23984 18573 241489 207565 22068 12267 233081 387513 110326 109648 12326 12322 14678 12323 108058 387353 12325 387515 26413 353148 242425 353165 387348 18798 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis 16770 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation 71773 552899 70484 94215 22236 213012 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 16476 18854 241915 11651 12151 15184 12418 433759 13001 99982 83409 100039026 54484 68031 14302 13653 56716 234366 252870 11652 20613 233833 26443 26444 19170 19181 26413 57296 14056 69077 245688 66997 23797 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation 16784 18815 21808 22138 12512 109711 11537 320202 12527 21922 67059 11818 110135 12631 27359 18613 14161 19039 71946 22388 12321 74840 66866 192176 99571 18407 72017 15234 16000 16002 19156 20344 11806 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production 72162 17874 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus 108138 101739 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK 18708 16367 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy 16784 11520 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated 226849 225849 26931 21770 26932 12387 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels 58802 16533 140492 140493 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K 18708 16367 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling 16163 22027 16171 53314 11651 257630 16160 16159 16451 21926 54721 15234 16409 100038891 83995 17829 14128 18708 20299 17161 16164 18126 17395 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions 170736 74202 21754 109711 16202 57342 192176 ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases 11980 170759 67331 72621 76295 12322 67972 12323 11941 108058 50771 12325 11928 192113 11931 11933 11944 11945 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors 11651 23797 11652 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA 446099 22040 56480 20821 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor 14675 14688 14704 14696 14693 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 12402 11651 13448 20459 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR 16542 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification 72416 83485 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis 18293 HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones 104263 225876 99982 319149 277250 20591 218214 193796 244694 71371 75605 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade 16476 26416 21770 170743 78287 192656 75669 26410 66589 17260 17087 21898 22030 107607 71966 17874 26940 69721 59025 67245 16179 26413 26395 71398 68652 27056 12234 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors 381853 14688 14704 14696 14693 20287 14607 93896 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 17222 68612 68999 668450 66156 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis 54722 21781 20230 11651 211586 68097 109620 18810 12367 18772 69146 11797 56702 14957 50708 13176 12261 269582 11652 19766 17087 21898 22030 14102 21933 12387 20740 26443 26444 19170 19181 26413 57296 69077 14939 56455 66997 14083 18107 23797 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 18534 20656 17128 16334 14377 109648 11604 14815 103988 433759 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development 15378 16869 16449 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria 21781 211586 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas 16779 14178 16773 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 264064 333639 225164 15184 56438 433759 19165 15208 11491 16449 76580 51813 100039623 16450 100042305 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle 12889 327814 20508 68507 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid 241452 242285 105014 26876 12903 216454 19401 16592 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 216820 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair 22427 68240 19718 19891 12021 26909 233826 106344 72151 225182 19367 69263 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling 114715 116701 114716 67112 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 56217 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling 14388 13649 18708 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling 13649 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones 66262 269003 78303 319181 69612 100683 216825 27878 20174 228829 21427 56505 109115 217031 66464 78656 208146 74026 319149 245688 72341 319183 70088 319182 15161 230233 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion 74126 57296 69077 66997 226861 26443 26444 19170 19181 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands 14102 21933 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis 54722 21781 11651 211586 68097 12367 69146 26413 14939 56455 18107 23797 12261 11652 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 68652 107607 66589 16179 192656 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells 14645 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration 11651 23797 11652 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 78894 15356 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR 11839 13649 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape 319944 209357 98053 67710 17749 100043714 66464 68776 99730 13872 23894 226182 66467 24074 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 56406 268903 12894 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants 110135 14161 18673 12322 12988 12323 108058 99571 109905 12325 26413 26395 26396 54519 109689 26403 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism 238505 54219 68421 21452 77697 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal 17314 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) 384783 234779 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP 12166 17128 12167 12168 12622 11705 17129 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 228421 226849 225849 26931 21770 26932 68097 73804 381318 18221 19047 232987 226747 108000 103468 12615 234865 66570 216965 625534 445007 56455 66977 13427 66468 110379 13424 57294 102920 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism 243382 12040 11992 12041 227095 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy 13001 100039026 11793 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants 110135 14161 18673 12322 12988 12323 108058 99571 109905 12325 26413 26395 26396 54519 109689 26403 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair 19718 18207 69745 26430 18970 11546 69263 68240 19687 19891 78303 57321 319181 319183 21750 18538 15270 319182 106344 72151 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones 69162 74126 225849 13191 68090 74322 50907 14583 28146 78943 71765 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 74104 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules 53869 18749 19084 19087 171504 24060 20544 27376 19299 11305 13723 224742 27404 11806 11807 216227 11772 11808 11771 269346 107566 27060 71279 140494 22333 225579 20278 243328 117160 170759 66144 170755 170756 67331 20528 234847 252972 20536 18673 11813 241118 73078 11814 20277 12034 11816 76295 216001 242341 215999 26373 381038 26372 12728 50771 380836 12727 70701 12725 12007 105243 12724 233280 110895 97086 226999 12723 11928 23844 192113 71803 233979 11931 11933 140475 11964 28253 11944 11945 14605 27219 68682 11980 26457 227394 226144 22784 230810 72002 14319 67634 70484 108115 101488 20502 237831 108652 58807 320718 20538 353169 20537 64452 79554 55961 12346 20515 20529 53945 11428 20516 12349 15203 18400 52466 107723 244373 105722 67075 74104 13521 13830 110891 20541 20521 67972 11941 14688 104245 14704 14696 14693 54411 17919 11640 11831 22335 67204 26905 58176 171382 108664 22068 68667 63873 64177 72621 76257 26443 26570 26444 50934 19170 20540 12322 12323 19181 108058 12325 72017 57296 320635 80879 69077 66997 238055 17777 330064 11812 67473 67582 75750 56453 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing 384091 66055 666609 98053 67710 68879 17749 100043714 78372 76167 192159 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation 16476 233833 13710 21781 13557 211586 333639 18131 625328 319149 78303 319181 319183 15270 319182 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription 192173 76007 56805 18746 13016 625328 21423 433759 26413 14056 99982 319149 245688 78303 319181 319183 15270 319182 13345 75339 20613 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 12261 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids 17001 330260 18979 269823 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase 242705 21781 13557 211586 12571 100043858 12447 12580 71978 12578 12579 20459 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 14348 14422 26878 20443 54613 80908 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) 56089 51801 14366 22418 14368 22421 14369 20890 14607 319757 381853 22410 14688 54409 14704 14696 14693 20287 93896 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation 67091 76308 67422 68097 67511 26938 66913 215474 207352 105522 107895 74498 67857 16334 66890 20442 24060 60409 20443 78232 216131 20440 50907 20447 208624 20741 19025 80297 67075 103534 108687 269181 56386 19359 13191 381903 11839 16834 20333 110379 99412 217615 14422 66174 18010 54613 50877 57170 14583 69080 19703 234730 12340 245847 56174 320011 76332 74126 56444 22644 54399 66435 67542 75841 66967 97484 66597 17309 50798 69162 20740 54130 11733 69654 20014 17155 103963 56455 13427 14376 68292 13424 69038 104318 13135 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex 11651 20675 17283 13016 12387 21415 433759 11652 12234 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 54721 16451 18414 12931 16880 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 26416 320139 11651 245866 81896 19271 18749 56438 19084 360216 106633 19087 16396 319757 70300 114715 114716 320484 12981 19762 69601 215854 18015 15565 101809 15550 54153 93896 74191 103468 226304 626596 98053 56089 13610 67710 51801 234865 19049 110135 387512 14161 239530 67792 22421 23925 20890 14061 29863 14608 99571 76854 21826 381853 64095 26385 445007 106512 22410 19222 14427 19217 110379 19218 30878 67839 14823 171469 20287 11772 13603 11771 227326 226849 27060 14739 212398 140494 381489 225849 12854 26931 13349 21770 387356 26932 66144 18155 12539 59079 18673 242341 16449 14573 16185 15904 19255 17242 18708 11682 11964 327826 16367 233833 19373 19374 14687 58861 12057 17874 16179 68652 23797 109689 21682 208884 12982 57294 19247 384783 19056 14686 22419 12283 225600 106042 16451 14366 22418 14368 14369 57437 18587 19671 70178 226016 192656 54721 20443 75669 54484 56480 11652 22195 70727 225724 18612 14675 14688 116701 14704 14696 12447 14693 13492 20698 13491 12468 16476 13710 21781 15382 13557 13858 211586 333639 18131 54613 71514 13819 11848 13448 12928 330662 106766 20459 23984 12402 18573 241489 14104 53817 14255 68031 14302 22068 207565 12267 19766 75705 22030 14102 13684 21933 100041766 12064 14402 432940 66552 21812 242274 18201 109905 73218 26413 26395 26396 242425 11812 18798 72149 69008 207911 19165 21828 17129 17872 21808 12166 11479 12167 14479 12168 100039623 20901 66573 12622 11705 100042305 234779 16410 17927 17928 13006 20843 14228 320207 268903 100041004 21687 12390 18534 14939 12830 13685 12829 12835 27371 11813 11816 74126 77125 15937 14170 83379 268980 13653 98432 67605 20613 58194 26876 16542 225164 13016 15208 192199 73130 17532 59036 13380 14160 30930 329252 108099 407821 63953 20675 54519 30955 226861 71520 26361 67738 214425 16798 12070 11551 84035 56705 21990 16450 18576 170749 98386 233081 76890 14678 260302 16334 624814 19299 228775 18755 433292 14064 65086 57260 233080 213788 104418 21334 235036 30044 12424 18441 18442 246691 331374 14745 16963 381810 225642 68039 229709 56533 14459 19735 78134 53978 210198 58182 12061 12062 269060 217480 14607 57810 19047 238505 100043508 19156 16000 19249 17179 20377 16204 16592 20299 252837 22236 20311 20297 20296 117150 22095 14309 67484 15234 67299 14388 16002 11839 14178 67112 21415 17863 22084 16594 16923 228421 26934 67414 73804 211770 170731 99982 108664 19349 12631 17886 241452 242285 105014 12366 12903 216454 241113 18854 227743 23988 54409 83409 17246 56716 252870 100683 14257 56505 104263 211652 14128 218214 193796 74194 50875 53382 11835 232339 93840 14815 109620 19401 20355 233877 380664 16709 216197 227937 233489 13001 21927 16590 100039026 216963 386750 239027 56419 232987 212285 74334 70497 23945 12261 224480 73296 18016 320795 109333 320271 208846 330319 67784 13058 13057 14570 13649 20740 11854 18751 17920 244418 270163 216965 14467 66871 213498 56455 195727 66977 13427 14083 207212 442801 18844 13424 226751 19354 329165 13726 12234 223870 102920 12229 214804 110279 11464 14026 18815 68097 75409 17228 269682 105855 381318 84004 12367 223254 27984 242687 11491 12988 11671 66087 18221 404710 104445 22284 23912 19418 109711 68089 26403 226747 66713 17393 74117 14269 108000 20741 17395 277360 241275 245880 76117 80297 263803 54004 12615 16779 66570 56324 20401 22376 59069 13830 66898 12568 69668 192176 71544 544963 21763 14056 56382 319149 625534 245688 11352 94221 319183 66468 17283 213783 16773 319182 77579 14270 106504 117600 94190 54411 225358 219140 264064 241915 83771 20249 12151 574417 15184 387347 17749 22632 57253 100043714 21926 57254 12418 387355 625328 387342 433759 387349 387616 76580 11797 106025 21937 51813 11796 78303 12006 319181 15270 17260 234366 20202 387513 109648 110326 12387 26443 21423 26444 12326 19170 12322 12323 19181 108058 12325 387353 57296 17128 387515 353148 69077 66997 353165 387348 16183 18791 12579 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma 11839 13649 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense 12362 14469 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination 17196 18858 16773 215798 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins 103468 100088 19069 445007 70699 234865 110379 18148 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 16513 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance 22589 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 14083 16410 71978 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway 258763 258729 258769 258325 170639 258752 18365 258939 258961 258305 100038859 100043474 259035 16825 257917 258819 259075 259058 18310 258659 18314 258896 257883 258587 258352 258287 258580 258321 259036 259034 18324 258985 258267 258832 668825 14688 18330 16870 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling 19056 229709 21770 19049 18749 19084 12326 12568 12322 19087 12323 14678 108058 12325 14675 26413 18573 14688 14704 14696 18798 14693 207565 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation 12229 56438 16396 212919 22210 75669 244421 66589 54484 76608 72194 16410 15204 56515 22209 140629 80898 22195 57751 74132 207304 231670 226541 104184 20193 672511 110135 69754 14161 77113 70294 67615 68729 100041484 207952 66743 99571 231672 56228 101358 321006 68098 14794 214931 217217 246278 117589 20333 74646 110379 57743 233902 231380 83962 20821 74153 30838 76580 20202 69162 17087 21898 17222 100041766 13058 17874 68612 216150 13057 68999 56371 668450 26443 26444 66156 19170 19181 57296 69077 66997 15007 12234 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD 29873 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling 57296 69077 66997 53859 26443 26444 19170 12234 19181 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair 12021 56420 77782 80905 225182 68240 19891 78303 319181 15270 15204 269582 22427 19718 69745 11546 69263 19687 26909 319183 18538 12427 319182 106344 269400 233826 72151 71711 268465 19367 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism 11677 72157 319625 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 11651 23797 11652 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination 18207 78303 57321 319181 319183 21750 15270 319182 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME 71279 11486 18102 269346 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport 79554 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment 11797 19766 11796 100041766 66589 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 19247 12064 327826 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System 26416 19271 18749 54644 14387 11891 12944 239447 16396 75612 11537 14962 67005 67065 218832 70408 110135 14161 15926 58992 14061 99571 140474 110078 110095 17829 18636 15212 230073 74153 11772 27060 140494 229709 21770 18010 66144 15442 224794 76295 54473 242341 14126 102595 332579 76025 12512 19141 17221 56373 78892 12902 93721 68724 18708 109828 26949 11964 12260 15439 12279 12262 667277 11980 12502 18746 19263 72461 227394 71966 17874 69721 620235 59025 72065 67245 381809 66681 16970 16179 16790 223978 18407 58222 20568 241197 68652 19156 14319 18813 83768 268379 21682 19340 19345 53856 67474 80861 72029 16783 22165 16784 19247 72162 19056 56619 12283 67781 230398 170743 66060 57437 192656 75669 66589 56480 16592 105722 67075 107607 18439 12362 66824 67955 383619 16428 20821 16476 54722 17909 17918 78287 11848 18772 12928 330662 12340 69146 56444 13036 11793 14302 108664 19349 12267 18126 19766 17087 21898 22030 53859 100041766 12631 216150 17886 242274 109905 26413 26395 238055 12366 23988 11886 83409 17159 16410 234779 19025 18613 26940 56615 72157 232449 109620 83382 70568 216197 13001 12261 266692 18016 68682 330319 13058 54445 13057 20740 12259 668101 16409 71398 56455 17084 100040603 27056 14083 13424 19354 329165 12234 216134 12229 68365 104112 13035 105855 214763 16621 217303 12367 242687 11717 23912 68089 668218 66713 74117 17395 245880 77559 20193 22376 13830 544963 319149 319183 319182 446099 22040 268857 14751 66222 17749 100043714 625328 11797 11796 78303 319181 15270 26410 17260 19695 54159 20202 22027 11927 19090 66557 57757 629114 12652 18843 11870 19152 72621 12387 26443 26444 19170 19181 57296 69077 66997 18792 20719 18475 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism 66569 233552 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 21351 14385 14377 105193 53412 75612 14387 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 66586 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 16542 14257 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism 19025 19156 18010 17113 11886 20597 15212 50877 271970 545260 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 27370 629957 100039316 100038991 666899 66481 225058 71978 100042986 625646 100042740 67891 67248 666669 27207 633683 432502 225363 67031 19989 229512 103677 19899 14852 19934 18458 75617 57294 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 11651 14257 333639 56438 26443 26444 19165 19170 15208 16449 19181 57296 69077 66997 100039623 100042305 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine 18207 78303 57321 319181 319183 21750 15270 319182 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 27370 16341 629957 100039316 100038991 666899 66481 225058 100042986 67204 625646 26905 100042740 67891 67248 75705 13684 666669 27207 633683 432502 19989 19899 19934 27979 18458 75617 56347 57294 223691 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage 12367 69146 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 109689 21812 21808 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism 54325 68801 15488 76267 56473 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 100039623 100042305 19165 16449 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling 54721 100041766 16451 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 19247 384783 214425 228775 14388 16000 16002 75669 14178 67112 14170 14255 83379 18708 327826 11652 16367 18576 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins 14058 14061 14071 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors 17260 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism 195646 93683 54613 56398 15442 71951 20442 20970 15366 78923 20443 15118 54371 75612 14735 20544 14734 215015 13521 56386 80982 217119 83398 70484 50786 29873 53625 15212 109685 108652 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 12402 11352 19271 14255 12988 16923 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair 26430 18970 11546 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity 233833 18854 19247 12571 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair 68240 19687 19718 19891 18538 69745 106344 18970 72151 69263 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH 14598 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex 264064 21781 211586 170749 11848 433759 17872 21812 21808 12402 26413 17128 19047 51813 14479 22284 20901 17283 16410 12579 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis 14593 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs 16590 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs 14025 215114 18148 19084 268980 11682 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA 69583 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse 213498 77579 11848 17886 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 14962 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells 12402 58194 13858 56324 12387 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism 66089 56705 17436 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane 53413 56297 207911 53869 18764 71492 319757 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance 238055 11816 PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import 15488 12908 103737 100041766 17117 15926 26378 56185 18634 65098 76263 16922 56794 22284 19193 18126 15356 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 58184 18983 18148 12227 219103 104625 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) 64051 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation 108664 11772 11771 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 15234 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 21351 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 14528 11651 20751 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes 319149 78303 319181 319183 15270 319182 625328 78658 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis 74126 57296 69077 66997 226861 26443 26444 19170 11491 19181 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 16450 11491 16449 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis 68240 19687 19718 19891 18538 69745 106344 72151 69263 18969 SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes 109075 56406 53314 66583 72544 17749 20926 100043714 93736 70122 80905 77622 52679 22083 56210 71890 319944 19718 98053 67710 68533 20833 21423 66464 66642 68776 99730 69263 108961 19687 242705 226182 24074 26909 18538 13716 50911 106344 72151 69639 17863 72662 227715 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis 105193 53412 72157 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins 103468 19069 445007 70699 234865 110379 101739 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis 21781 211586 12224 19401 625328 319149 78303 319181 14581 319183 15270 319182 17863 14247 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 75612 15212 EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle 108138 101739 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle 74126 22644 66435 75841 66967 66597 14376 108687 320011 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense 12362 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants 11682 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism 13479 72303 26457 330260 269823 77219 631304 17001 100043508 18979 14598 19215 12408 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors 56089 54409 51801 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity 13370 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions 14118 16409 12829 16542 110135 14161 18613 12822 16410 15898 99571 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation 667277 12944 12259 12260 12262 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO 223870 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters 20529 53945 170756 22784 110891 230810 15203 20541 72002 105243 110895 226999 20544 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter 67065 218832 70408 71752 17749 100043714 67005 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK 12229 14688 14704 14696 14693 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters 55961 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion 11811 71281 11810 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle 26416 12021 66181 76308 11651 245474 59092 56438 71978 225182 50496 68240 19891 15366 17246 18148 269582 29813 22427 103468 19718 19069 13006 140557 70699 20843 50878 67710 217716 234865 56739 20174 77053 56505 69745 100043858 12580 218914 208092 19687 100088 66700 445007 12537 110379 226849 225849 26931 21770 26932 629959 380664 13001 19047 100039026 232987 14235 14245 17222 68612 72107 68999 108689 56371 668450 76816 66156 54130 18751 219103 12578 217718 22142 59126 68475 69654 216965 18536 208518 381644 56455 236266 66977 13427 99100 214552 103733 23797 13424 219072 16475 104318 13726 12234 51885 16328 57294 102920 233276 12442 71909 28135 17997 214444 68097 381318 26374 105522 74498 67857 18221 208084 57441 226747 18392 15204 18393 11652 108000 21664 12615 66570 382030 228829 242705 319149 625534 245688 22151 319183 66468 238463 319182 268930 12447 74549 78658 18969 228421 99412 21781 13557 211586 22171 73804 17749 100043714 625328 433759 20459 98386 57321 78303 22589 319181 21750 15270 17865 233532 66578 26443 66634 30949 26444 12544 19170 69270 272551 69263 19181 57296 26413 69077 66997 26909 12571 18538 12427 106344 269400 72151 12579 19367 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 225164 16450 11491 76580 16449 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle 320795 26934 109333 110279 19299 263803 208846 59079 84004 11848 13830 404710 98386 213498 207212 56419 18708 94190 12261 277360 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP 18815 13035 12558 11816 16709 216197 246228 208659 76453 16007 16012 74761 16011 16010 83995 14734 22027 66557 56047 16779 14161 269181 12321 14061 99571 14118 16000 238055 16002 17283 11806 11807 56453 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina 14245 382030 18751 380664 13726 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics 11863 72303 56448 11864 74134 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD 243382 12040 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus 100039623 100042305 19165 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 97212 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 56406 20249 14104 100705 17764 14593 235293 56453 170439 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome 26413 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors 18749 18639 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 107723 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis 26413 672511 71514 13035 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein 20815 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) 11546 77782 225182 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer 21812 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair 22427 19718 18207 12021 225182 69263 68240 19891 26909 233826 106344 72151 19367 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion 76007 20901 17246 15426 16201 14056 319149 245688 319183 319182 13858 625328 433759 18554 13001 99982 78303 319181 100039026 15270 13345 75339 20613 233833 12552 192173 56805 16601 18746 114142 239096 13016 227485 230738 12387 26443 21423 26444 19170 12564 19181 20014 57296 26413 103963 69077 66997 14376 69038 15376 13135 53325 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation 229709 16542 18751 20698 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 13001 26413 26395 26396 100039026 13649 16410 16728 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 24060 70484 108652 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance 171504 238055 11812 11816 11806 11772 11771 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG 269060 23945 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 20202 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism 17159 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions 72303 56448 74134 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis 50798 19025 66174 67422 18010 26938 54613 50877 57170 14583 69080 19703 234730 245847 56174 24060 20442 20443 20440 20447 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling 19247 14170 83379 327826 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB 17874 16179 192656 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases 26416 11651 227743 260302 19271 18749 19165 21828 16396 16334 100039623 114715 114716 100042305 19762 16410 56716 98053 67710 14257 228775 21826 12830 11772 11771 27060 140494 229709 21770 12829 66144 12835 12539 59079 27371 11816 242341 16590 15904 19255 14170 83379 17242 74334 18708 13653 11682 11964 327826 16367 58194 16542 13058 13057 13649 18751 68652 16000 14083 21682 23797 329165 19247 384783 18815 71520 17228 214425 105855 242687 17179 11491 12988 75669 11652 17395 245880 16779 56324 12568 15234 67299 56705 14388 16002 21990 11839 16773 14178 116701 67112 54411 20698 18576 16923 15382 13858 211770 17749 100043714 11848 433759 12928 330662 20459 12402 17260 14255 108664 76890 12064 12387 14402 109905 26413 26395 26396 18791 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET 19247 58194 13858 16779 260302 56324 19271 12928 109905 12402 15234 67299 14388 56705 14083 16773 19255 74334 18708 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 71446 83762 19122 28146 13726 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 57296 69077 66997 26443 26374 26444 19170 19181 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion 208092 66700 18571 73711 22088 67123 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D 57296 69077 66997 26443 26444 19170 19181 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 22427 12021 26909 233826 225182 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide 12354 12346 23831 12349 12350 12353 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation 98053 67710 13716 17749 100043714 20833 ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes 19687 19718 26909 18538 106344 56210 72151 71890 80905 69263 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence 16476 26416 241915 21781 13557 211586 12151 50932 12418 625328 26921 78303 319181 17246 26408 15270 233833 100043858 12580 12578 26413 242705 14056 319149 245688 319183 12571 319182 12579 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription 333639 67784 18131 211652 15208 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria 21781 211586 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 20537 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 17087 21898 68652 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway 26416 229709 11651 227743 27371 105855 18749 11848 12928 242687 330662 16410 18708 56716 11652 245880 16542 13058 13057 12387 18751 228775 14083 23797 329165 20698 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation 12819 17384 12822 58223 11491 30800 17381 71753 12816 83995 17393 12821 17395 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle 108099 12894 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin 50493 12527 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade 19247 384783 228775 14388 75669 14178 67112 14170 14255 83379 18708 327826 11652 16367 18576 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits 27370 16341 629957 100039316 100038991 666899 66481 225058 100042986 625646 100042740 67891 67248 666669 27207 633683 432502 19989 19899 19934 27979 75617 56347 57294 223691 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade 16476 26416 21770 22030 107607 71966 17874 26940 69721 59025 67245 16179 192656 26413 26395 68652 66589 26410 17260 12234 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated 226849 225849 26931 21770 26932 12387 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis 67895 74776 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation 67065 218832 70408 20823 66653 71752 17749 66596 100043714 102209 75627 67005 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants 76007 110279 67529 18708 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing 54196 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 11651 56438 16396 319944 103468 19069 98053 70699 67710 234865 108138 18571 20833 73711 66464 68776 99730 14061 22088 67123 208092 100088 66700 445007 226182 24074 18107 13716 110379 230073 74153 11772 667370 11771 28084 66999 19047 11928 11931 11933 18708 58861 16179 633683 66603 100043508 20014 252903 66383 103963 68652 53975 14376 68292 15007 23797 69038 208884 19345 20815 13135 75617 57294 27370 19247 56217 629957 100039316 233870 100038991 230398 16451 170743 233405 66481 57437 77573 225058 192656 107895 54721 71951 20442 20970 20390 20443 75669 66589 80743 20440 14735 56480 20447 105722 11652 14734 384091 666609 16171 67075 257630 107607 103534 108687 269181 12362 27207 66824 71732 69035 231380 15382 15353 99982 14104 64340 233073 108664 68981 19766 54196 17087 53379 21898 13684 18854 227743 234779 18148 56716 14228 107392 11806 19035 14815 13001 100039026 67891 12737 58194 666669 27967 13649 16177 12259 70616 216965 67959 56455 432502 100040603 13427 19989 13424 19899 67439 19934 20646 12234 192159 12229 74326 68097 75956 214763 666899 66101 217303 22174 234852 20168 66055 68816 100042986 68879 17069 625646 100042740 230861 22083 17395 67418 213539 54633 209357 68219 67248 56445 18391 57261 57905 23989 68479 66642 100732 13872 228005 17060 67279 15569 14056 319149 245688 66467 16834 319183 60321 319182 246728 50724 16649 17713 60406 264064 216154 80509 17749 100043714 433759 234959 23894 51813 78303 319181 101739 70208 234366 192292 12387 26443 26444 19170 12322 12323 19181 108058 12325 57296 17128 69077 12846 66997 18458 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 100038891 18999 620395 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication 56438 625328 68240 19891 78303 319181 15270 57441 18392 74528 18393 19718 17222 68612 226153 68999 69745 56371 26443 66634 668450 12544 26444 66156 69270 50776 19170 272551 69263 19181 57296 19687 319149 69077 66997 319183 18538 12427 319182 106344 72151 12447 18969 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 12402 54721 19247 16451 18414 12931 16880 CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway 66824 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis 16325 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 15212 PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization 68185 22333 67264 100041835 83762 12908 17117 19122 73078 15526 67105 18634 65098 16922 22284 71446 66119 66169 28146 100900 19193 18126 66821 19299 15488 20524 103737 100041766 15926 53375 26378 56185 76263 56794 17713 100042179 13726 21855 636544 15356 103172 66437 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway 58194 19699 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 21812 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome 12362 66824 383619 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor 110637 14809 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis 104418 269060 217480 331374 18755 22068 23945 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis 14348 14422 26878 20443 54613 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins 109905 14083 110135 54519 14161 99571 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism 54325 68801 76267 56473 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein 14376 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes 98053 67710 17749 100043714 68776 99730 226182 229543 13716 70422 75137 71957 77065 102209 75627 71177 69917 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism 13036 20390 12945 18442 20387 12982 11551 216197 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses 60510 75409 22343 327814 68507 20980 20168 106025 386750 216028 74342 245450 26556 272381 228836 239250 245537 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function 57296 13858 69077 66997 17246 12387 26443 26444 19170 53325 19181 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway 264064 216154 80509 230398 16451 170743 56438 234959 54721 66999 13001 71951 19047 20970 51813 100039026 14735 70208 14734 17087 21898 23989 13649 67279 246728 19345 230073 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type 29873 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 233081 229709 18749 19084 19087 11551 14678 109905 14675 240444 16334 14688 74205 238076 238276 14704 14696 14693 16500 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity 26413 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery 98053 67710 13716 17749 100043714 20833 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation 105148 22321 353172 66590 70560 107271 67895 230577 110960 74776 224805 70120 67417 13722 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling 19247 18854 16391 17750 16451 214158 229900 93679 67525 12322 12323 108058 12325 26413 54139 224762 27056 15007 14469 246728 20821 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones 56453 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification 99412 67091 217615 76308 68097 67511 66913 215474 12340 207352 105522 107895 76332 74498 56444 67857 54399 16334 66890 67542 60409 97484 20443 78232 17309 216131 20440 50907 20741 69162 80297 103534 269181 56386 20740 54130 11733 69654 17155 13191 11839 56455 16834 13427 20333 110379 13424 104318 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events 12325 18573 18749 19084 12326 12322 207565 19087 12323 108058 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants 11682 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy 208092 66700 73711 22088 11520 67123 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases 271970 545260 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism 218865 68682 74129 110695 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 19247 14388 14178 67112 18708 327826 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters 20515 20516 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation 26416 68652 107607 66589 16179 192656 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 333639 67784 225164 18131 13649 19165 15208 16449 76580 100039623 16450 211652 100042305 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 228775 225058 633683 432502 100042986 67204 19989 625646 26905 100042740 19899 19934 75617 57294 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events 19056 21770 19049 18749 19084 19087 12568 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 15234 19247 14388 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 58226 11651 18439 16410 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling 233833 13685 72149 69008 75705 12283 11651 13684 83409 108099 23797 241113 56716 22084 67605 11652 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 12325 12326 207565 12323 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 75986 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 11839 13649 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization 22788 12527 329954 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 17001 13479 14598 631304 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 57296 69077 66997 56438 26443 26444 19170 19181 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 72057 66923 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland 11839 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease 109075 66583 72544 50911 69639 72662 227715 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 17222 68612 68999 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events 109905 26413 26395 26396 12928 327826 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism 238505 67870 246221 269378 73748 27376 66071 12583 12411 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle 67414 170731 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense 100041766 14469 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition 21781 11651 211586 22171 629959 433759 50496 20459 68240 19891 57441 18392 18393 11652 26443 66634 12544 26444 19170 19181 57296 69077 66997 18538 12427 23797 12447 18969 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) 56406 20249 14104 100705 17764 14593 235293 170439 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated 226849 225849 26931 21770 26932 12387 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 208595 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance 171504 238055 11812 MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase 99412 12442 76308 625328 380664 74498 78303 319181 15270 103468 19069 70699 234865 14245 382030 18751 217718 59126 26413 319149 445007 319183 319182 110379 78658 13726 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 21781 211586 59092 12227 219103 104625 108961 58184 18538 12427 52679 18983 18148 12447 29813 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex 18392 66634 18393 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 56406 12862 380975 12013 14950 106766 12861 100041785 20459 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function 233833 12552 15426 16201 239096 12387 12564 20613 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity 18854 26416 12021 76367 69260 11651 227743 23988 67338 66262 225182 68240 19891 17246 15257 56716 252870 11652 69181 29813 319944 22427 117150 19718 228829 20833 66464 68776 12568 99730 245688 226182 24074 26931 433759 13001 100039026 234366 69263 57748 18996 108099 26909 12427 70088 241113 23797 106344 72151 219022 19367 53325 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 109905 240444 14688 238076 238276 14704 18749 14696 19084 14693 19087 16500 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 22284 78303 319181 22210 67196 22083 22209 252870 22195 19090 233900 68366 320311 108089 103737 100041766 216150 68612 67615 432940 319183 18538 15007 319182 231380 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 12981 18751 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis 19766 22030 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells 16779 16773 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing 98404 208366 15108 28088 76367 67676 67053 74097 66161 68045 67724 68291 230734 229780 66965 67049 108943 328162 69786 103468 19069 70699 66132 68626 234865 52575 445007 67674 110379 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly 18749 11806 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 16590 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis 192289 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response 27370 16341 629957 100039316 27207 66481 225058 633683 27979 75617 56347 667370 57294 223691 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 14184 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 226849 19247 384783 225849 26931 11651 21770 26932 16334 16590 77125 15937 14255 14170 83379 268980 18708 327826 16367 117150 320207 17874 12064 13649 16179 26413 15234 14388 11839 14178 67112 30955 19354 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes 56187 66494 57913 12366 14102 21933 66813 12362 64058 12905 225655 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism 71951 20970 13521 29873 14735 15212 14734 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters 20537 71279 53945 26361 20516 15203 18400 24060 107723 244373 28253 103468 19069 70699 234865 74104 13521 103988 226144 26443 26444 20540 19170 20521 19181 57296 445007 69077 66997 110379 104245 68421 11806 216227 20538 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ 16784 18815 21808 22138 12512 109711 11537 320202 12527 21922 67059 11818 110135 12631 27359 18613 14161 19039 71946 22388 12321 18751 74840 66866 192176 99571 18407 72017 15234 16000 16002 19156 20344 11806 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling 21926 11848 12070 12367 19165 433759 11491 192656 76580 11797 106025 21937 11796 100039623 19418 100042305 56480 22195 277360 19766 22030 14102 21933 100041766 17874 432940 16179 66552 18201 73218 213498 68652 12366 207212 442801 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication 21781 211586 18392 66634 18393 18969 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression 264064 50493 56406 216154 80509 170826 13122 26379 230753 234959 66999 11863 51813 70208 26457 11864 23989 17436 228775 67279 14200 76267 17764 12894 11806 11807 11520 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors 233081 233080 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 22427 12021 26909 233826 225182 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle 19249 53382 232339 93840 18844 109620 380664 18708 327826 11671 227937 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome 19247 14388 11839 13649 18708 12988 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication 213539 67075 56445 13684 20168 20014 103963 14104 18107 68292 69038 230861 16649 11806 13135 18458 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 22284 67196 22210 100041766 216150 68612 231380 67615 22209 252870 432940 22195 INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling 19373 15234 384783 19374 319149 16451 16197 57914 18708 16367 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants 14255 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis 13190 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation 108664 11772 11771 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint 12442 12427 268930 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling 12502 14026 19260 100041766 216150 19271 22376 26443 26444 19170 12988 192656 19181 57296 69077 66997 68652 16428 66589 234779 18708 12234 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis 103468 19069 98053 445007 70699 67710 234865 17749 110379 100043714 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate 68631 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 242705 21781 13557 211586 12571 100043858 12447 12580 71978 12578 12579 20459 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases 11651 71514 14815 13819 11848 13649 13448 12928 330662 106766 20459 12402 12447 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 19718 69745 80905 69263 68240 19687 19891 68098 18538 106344 72151 56210 71890 74153 22224 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants 16590 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis 103468 19069 70699 21770 13806 234865 18749 103988 18639 18640 170768 100043349 445007 56421 110379 270198 13807 14751 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 22151 238463 22142 12468 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures 12819 192897 12829 12835 16949 12822 16950 18810 69675 30800 21892 12830 12153 17393 17395 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 56480 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway 15007 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels 20866 269717 18439 22068 18438 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors 74191 78134 235036 18441 18442 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste 21906 20278 387513 83771 110326 574417 387347 57253 57254 20277 387355 387342 387349 546729 387616 387353 387515 353148 14688 353165 387348 68667 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 16450 11491 16449 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type 77697 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis 19025 18010 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling 15234 16779 14083 16773 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand 22427 68240 19891 57321 21750 18538 69745 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling 216963 13846 13845 270190 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 12402 54721 19247 16451 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 18119 17128 26413 11479 23863 320202 12622 620395 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation 319149 78303 319181 319183 15270 319182 625328 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism 103468 19069 70699 13684 234865 23988 16451 445007 110379 230861 230073 16649 74153 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions 17752 17750 17764 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) 14675 26413 14688 14704 109689 14696 14693 14061 14064 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling 26413 12340 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling 16185 16168 16451 16183 12981 60504 18708 12982 60505 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane 76257 26570 50934 20540 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends 78303 57321 319181 319183 21750 15270 319182 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 18207 78303 57321 319181 319183 21750 15270 319182 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway 17309 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t 72157 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters 20521 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 213498 100039623 12366 19418 207212 442801 100042305 12070 12367 19165 277360 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 19766 71966 17874 69721 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC 99010 237625 225845 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly 12442 103468 70699 234865 380664 71978 22142 208092 100088 98386 66700 445007 22151 238463 110379 226747 13726 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family 140474 56619 17829 234779 381809 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 14178 67112 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease 14388 18708 327826 GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 60510 106025 216028 74342 22343 26556 228836 245537 20980 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 20516 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation 239447 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 12552 12387 330662 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 384783 14388 320207 30955 18708 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis 12229 245880 12502 17909 17918 330319 105855 22376 12928 242687 330662 17886 26413 14083 68089 66713 329165 74117 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function 12021 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane 105722 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification 67091 76308 26938 22658 72433 54644 56438 68328 107260 360216 11891 19326 246179 16334 24060 243853 60409 67843 212712 75847 78232 228366 216131 17342 271970 269582 103468 19069 70699 234865 108138 14161 14058 14061 14071 99571 21826 140474 66548 445007 330267 207596 224697 223838 20356 110379 17829 18636 233826 230073 14422 18010 14276 69082 66632 69740 13494 105638 68612 59025 18970 58222 20014 103963 14376 68292 15007 109689 67711 19340 69038 67241 19345 55989 21974 13135 67872 12558 19671 26374 192656 107895 20442 623661 276846 20443 212919 170745 22210 67196 64931 246190 114654 20440 17068 72194 237847 15204 11650 20447 68468 22209 14756 230801 14734 22195 68404 433931 21684 21683 67075 231670 56047 226541 66459 107607 329777 103534 71003 108687 69754 269295 269181 77113 67615 207952 74653 14537 231672 272411 171212 101358 78754 108760 212996 11839 14794 71685 214931 80294 22151 217217 117589 20333 74646 233902 231380 83962 30838 99412 66174 54613 13819 57170 11848 69080 234730 12340 76332 56444 76877 54399 67542 97484 22335 68031 19349 50798 19766 22030 100041766 216150 11733 432940 21812 17155 238055 18538 12427 223499 22224 56453 56187 18854 12021 69260 69834 53869 67511 66913 16588 68043 239706 72096 70511 14479 17246 67151 53380 50907 66537 53417 18148 22217 74270 71472 252870 217057 69641 30940 22427 235323 19025 327799 100683 13006 319651 216825 20843 268903 56505 108679 12321 13194 19358 19359 22591 26895 26894 225363 53625 218214 54638 11806 66498 11807 59043 233805 73828 234664 66199 22333 242418 217615 74251 415115 11835 22337 14815 231093 19401 237930 229615 11816 244071 320244 16709 238328 216197 67269 320011 226841 74126 22644 66435 75841 66967 66597 77125 69162 13016 20740 54130 22142 69654 56455 13427 13424 104318 12234 223870 68365 67422 68097 215474 207352 246228 105522 208659 74498 76453 11504 67857 16007 66890 74761 22284 16011 16010 17069 22083 208624 19329 20741 76338 53868 80297 16779 56324 56386 14118 56382 13191 245688 381903 16834 319183 17283 319182 15161 241915 20230 12151 22632 50877 12418 14583 433759 19703 245847 545260 56174 11797 11796 78303 12006 319181 17309 22027 19090 66557 233900 68366 320311 108089 103737 26443 26444 19170 19181 57296 17128 69077 66997 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation 18854 117150 11651 245688 69260 23988 70088 23797 66262 433759 234366 11652 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway 19766 17087 21898 22030 14102 21933 13176 12367 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 384783 PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair 110265 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 226849 225849 26931 21770 26932 18673 12322 12323 108058 12325 17532 26395 19047 26396 26403 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors 20202 238055 11801 11806 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors 238055 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 12527 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 57296 69077 66997 74104 244373 226144 26443 68421 26444 11806 19170 19181 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) 20202 12229 17087 21898 20193 110135 17874 14161 99571 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 16476 12229 26416 21770 192656 26410 66589 17260 20202 17087 21898 22030 20193 107607 110135 71966 14161 17874 26940 69721 59025 67245 16179 99571 26413 26395 68652 12234 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 241196 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 264064 17128 26413 21781 51813 211586 22284 17283 433759 12579 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation 27060 27370 629957 100039316 66144 100038991 666899 66481 242341 101148 225058 277854 230676 83409 100042986 67204 625646 26905 100042740 98402 108664 56716 71962 11964 319481 67891 67248 666669 27207 56032 228775 633683 432502 19989 110379 19899 19934 75617 57294 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling 16476 26416 16171 21770 257630 107607 140806 16179 192656 26413 26395 68652 66589 26410 17260 12234 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination 12021 54644 107260 360216 19671 192656 14479 22284 17246 22217 74270 71472 269582 252870 217057 69641 30940 235323 327799 100683 319651 216825 107607 56324 56505 19358 19359 319183 319182 218214 15161 230073 22333 11835 22632 11848 11797 11796 12006 78303 319181 77125 22335 68031 19766 22030 59025 26443 18970 26444 19170 19181 21812 57296 17128 69077 66997 12427 109689 22224 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 17222 68612 68999 56371 26443 668450 26444 66156 19170 19181 57296 69077 66997 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events 229709 18749 19084 12326 12322 19087 12323 14678 108058 12325 14675 26413 18573 18798 207565 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 109075 70640 66583 22695 72544 50911 69639 72662 227715 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction 17898 58226 216459 59069 239556 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling 16476 11651 67738 22632 17749 100043714 625328 433759 99982 78303 319181 15270 268980 17393 18708 11652 17395 233833 98053 13006 13610 20843 67710 14228 268903 100041004 13649 14678 12390 26413 100043508 319149 11839 14688 319183 14083 319182 23797 14704 14696 193796 14693 17863 20698 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 19247 14388 18708 327826 GSD II%REACTOME%R-HSA-5357609.5 GSD II 14387 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism 71562 209176 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus 103468 19069 445007 70699 234865 110379 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants 109905 26413 26395 26396 110135 54519 14161 109689 12988 99571 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling 100043508 11863 11864 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination 384091 243963 666609 68219 54196 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels 20278 117160 170755 252972 241118 20277 26373 26372 12728 12727 12725 12724 97086 12723 23844 233979 171382 140475 105722 22068 68667 63873 64177 14605 27219 13830 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions 18845 140571 20361 67784 20356 18844 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) 57296 18247 18104 69077 66997 26443 26444 19170 19181 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 11848 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 18970 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle 22343 216456 214579 17161 12889 327814 20508 68507 14660 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation 209357 23894 245688 106298 66467 75316 21429 17749 100043714 433759 234366 13872 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion 15108 83485 66132 68626 52575 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide 12346 12349 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling 12366 12070 12367 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants 14255 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 12021 56438 77782 69090 225182 208836 68240 19891 14088 17314 237211 22210 67196 330554 55947 15204 269582 252870 22427 19718 209357 67710 108138 56505 57905 69745 11546 108679 13194 19358 13872 14050 19359 11785 22591 19687 26895 26894 227525 68098 75570 66467 56626 319183 56196 13716 319182 193796 233826 71711 268465 74153 18207 56420 17749 22632 100043714 229615 80905 23894 57321 14048 78303 319181 21750 15270 75452 56210 71890 19090 26430 26443 18970 26444 19170 69263 19181 57296 69077 66997 26909 18538 12427 106344 67439 269400 72151 22224 19367 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 16542 668218 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 68652 100039623 100042305 13649 11816 19165 18708 14402 11491 16396 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism 19025 18010 17113 26938 11886 56386 50877 22239 223753 545260 19156 20597 15212 239559 271970 14421 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death 11651 68097 12367 16396 56702 14957 50708 269582 11652 22195 18571 12362 208092 66700 14939 18107 54722 21781 211586 20230 12539 109620 18810 18772 69146 11797 11796 13176 12261 19766 17087 21898 22030 14102 21933 12387 20740 67245 26443 26444 19170 19181 57296 26413 69077 56455 66997 14083 23797 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 97212 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling 12402 16590 16923 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 12367 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 21781 11651 211586 629959 26443 26444 19170 20459 19181 57296 69077 66997 12427 23797 12447 11652 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G 57296 69077 66997 56438 26443 26444 19170 19181 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors 26361 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 109791 67717 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 50493 20656 67305 11927 13058 13057 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex 68240 19891 57441 18392 66634 18393 12544 18969 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 24060 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 18708 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly 238055 17777 11812 18749 11813 11814 11816 11806 11807 11808 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA 384091 243963 666609 68219 54196 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL 97212 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 28253 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 13072 110115 11677 66065 59045 15483 76205 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 12402 26413 19247 14388 114715 116701 114716 67112 18708 327826 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 19718 209357 67710 17749 100043714 57905 69745 56438 13194 13872 69263 68240 19687 19891 23894 66467 18538 106344 67439 72151 252870 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants 16476 14025 56438 19084 433759 54721 12047 215114 17246 18148 268980 18708 11682 327826 16367 69162 14235 70297 672511 59069 17886 26413 13191 14939 67160 18646 54167 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels 16521 16513 242425 14688 16519 14704 14696 14693 16516 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 72002 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 12387 21415 433759 12578 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 99412 67091 217615 76308 68097 67511 66913 215474 12340 207352 105522 76332 74498 56444 67857 54399 16334 66890 67542 60409 97484 78232 216131 50907 20741 69162 80297 20740 54130 11733 69654 13191 11839 56455 16834 13427 20333 110379 13424 104318 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA 14056 319149 245688 78303 74016 319181 103551 319183 15270 319182 625328 11569 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth 58226 14573 26413 80297 12829 12835 14083 19122 20740 239556 12830 20741 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 54721 26413 19247 26395 26396 63953 16451 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors 381489 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex 209357 98053 67710 17749 20926 100043714 93736 20833 70122 13872 23894 66467 13716 22083 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis 54325 20249 68801 19063 14104 74205 104112 106529 74522 30963 170439 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends 22427 19718 12021 56420 225182 69263 68240 19891 78303 319181 26909 319183 12427 15270 319182 106344 72151 15204 269582 19367 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors 57260 19222 58861 19217 19218 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy 22333 67414 66119 100041766 66589 22335 11793 66169 56480 170731 22195 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization 16542 14257 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion 14071 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 11839 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency 217214 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 22418 11772 11771 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination 11486 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) 109075 70640 225849 66583 72544 14583 71765 74126 67204 26905 50907 28146 78943 69162 22027 68090 74322 75766 26427 12913 13191 50911 69639 72662 56453 227715 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 56438 26443 26444 19170 16396 57810 19181 319757 57296 69077 66997 66573 109689 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 50798 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways 103468 19069 54196 445007 70699 234865 110379 16649 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle 50875 53382 12539 109711 53817 106504 17920 12468 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 72258 16526 16528 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 68240 19687 19718 19891 18538 69745 26430 106344 18970 11546 72151 69263 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant 14058 14071 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation 18392 66634 18393 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11444 231252 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT 12402 19247 16590 71520 17228 21682 18708 16923 17395 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome 11811 71281 11810 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor 12325 19418 12322 12323 108058 242274 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription 14815 56461 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type 71951 20970 29873 14735 14734 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling 16185 16168 16451 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins 18854 241915 20230 69260 12151 11835 22658 22337 14815 19401 12418 229615 433759 212712 17246 18148 15204 17342 22427 103468 19069 13006 70699 20843 234865 268903 108138 13016 22591 445007 18538 110379 67711 67241 55989 21974 67872 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes 17874 16179 192656 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol 27370 109075 78394 216987 208366 66181 629957 66583 27993 67676 100039316 67205 67053 245474 100038991 72544 27966 59028 100608 18572 666899 66481 225058 100042986 625646 100042740 67248 68533 27207 24128 67891 30877 666669 229504 67045 66164 69072 53414 633683 432502 67674 19989 223499 213895 50911 19899 100041622 55989 72554 69639 19934 98956 104318 622491 75617 72662 234374 57294 227715 73674 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression 233833 14815 56461 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) 68015 380840 17448 67680 18115 18293 269951 170718 68332 66052 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis 26938 56386 239559 22239 223753 14421 FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants 12402 14255 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation 11651 66394 20751 18107 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation 26416 19271 11886 14387 11891 83409 17159 75612 16410 11537 19025 18613 15926 56615 110078 110095 18636 15212 11772 72157 27060 18010 232449 15442 109620 83382 224794 76295 54473 70568 216197 102595 13001 76025 12512 78892 68724 26949 15439 266692 68682 11980 18746 19263 72461 227394 13058 13057 20740 72065 381809 66681 668101 16970 16790 223978 18407 58222 16409 20568 241197 56455 19156 14319 100040603 18813 83768 268379 19340 13424 19345 53856 67474 216134 16783 16784 68365 12283 67781 104112 13035 105855 66060 217303 57437 11717 23912 668218 16592 66713 105722 17395 67075 77559 66824 13830 544963 14751 66222 11848 18772 69146 56444 13036 14302 19349 12267 54159 20202 19152 19170 242274 19181 109905 26413 69077 66997 18792 20719 18475 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 233081 14675 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 17222 68612 68999 26443 668450 26444 66156 19170 19181 57296 69077 66997 12427 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 74104 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 16590 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly 14621 118454 14616 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants 14255 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN 446099 56480 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 100039623 225164 16450 100042305 17242 19165 76580 16449 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 20521 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea 17921 97031 381375 193385 140492 241431 20740 17886 16533 231252 140476 56506 13860 19684 22295 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression 18432 319149 78303 319181 319183 75316 15270 17749 319182 100043714 625328 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 22427 12021 26909 233826 225182 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy 22333 67414 68097 93739 13819 170731 13001 83409 100039026 75669 66119 66589 22335 56486 11793 66169 56480 56716 22195 100041766 208092 66700 56455 108099 13427 666468 241113 68118 51897 13424 67841 235040 22084 11520 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors 12325 170483 22343 12322 12323 108058 242274 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity 233833 12325 98386 12326 433759 12322 12323 108058 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases 66222 12367 69146 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 57296 69077 66997 56371 26443 26444 19170 12234 19181 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants 11682 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters 27376 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System 20202 12229 17087 21898 20193 110135 54445 17874 14161 170743 58992 16621 14061 99571 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity 57296 69077 66997 17702 170826 14815 56438 26443 26379 26444 19170 19181 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion 228421 226849 12442 225849 26931 21770 26932 68097 73804 381318 18221 19047 232987 226747 108000 103468 13006 20843 12615 234865 66570 218914 216965 625534 445007 56455 66977 13427 66468 110379 13424 57294 102920 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME 22436 18102 269346 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 268980 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase 12442 68097 381318 71978 18221 226747 108000 103468 13006 70699 20843 12615 234865 66570 218914 208092 100088 66700 625534 445007 22151 66468 238463 110379 226849 228421 225849 26931 21770 26932 73804 380664 98386 19047 232987 17222 68612 68999 668450 26443 26444 66156 19170 22142 19181 216965 57296 69077 56455 66997 66977 13427 13424 13726 57294 102920 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress 109075 70640 66583 72544 50911 69639 72662 227715 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation 12325 12322 12323 108058 242274 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 26361 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling 18749 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 210789 68365 53413 68938 11651 74741 17918 53869 20528 68328 17886 108099 241113 11652 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex 208092 66700 75669 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 18708 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress 68240 19718 19891 106344 18392 66634 72151 18393 12544 269582 19367 69263 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 16590 233107 106931 22632 13649 18148 11816 70472 18741 75605 17865 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation 319944 209357 98053 67710 17749 100043714 66464 68776 99730 13872 23894 226182 66467 24074 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence 15364 56702 14957 78303 50708 57321 319181 319183 21750 12427 15270 66403 319182 12447 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair 12021 56438 77782 225182 68240 19891 15204 269582 22427 19718 108138 69745 11546 13194 14050 11785 19687 227525 75570 56626 319183 56196 319182 193796 233826 71711 268465 56420 80905 14048 78303 319181 15270 19090 26443 26444 19170 69263 19181 57296 69077 66997 26909 18538 12427 106344 269400 72151 19367 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle 17161 12889 327814 68507 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling 18749 19084 19087 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C 17222 68612 68999 668450 66156 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells 12396 14726 100038891 18999 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) 57296 69077 66997 246278 26443 26444 19170 19181 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism 22275 15288 28253 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 319149 245688 78303 319181 319183 15270 319182 625328 433759 234366 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 22632 17749 100043714 56438 229615 68240 19891 23894 252870 19718 209357 67710 56505 57905 69745 11546 108679 13194 13872 19358 69263 19359 22591 19687 26895 26894 66467 18538 13716 106344 67439 72151 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation 14178 67112 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 16476 57261 13819 12387 625328 14056 319149 245688 78303 319181 21679 319183 21678 15270 319182 21415 21677 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation 109821 14071 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling 14687 14688 14704 18749 14696 19084 14693 19087 14678 76854 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis 19718 69745 80905 69263 68240 19687 19891 18538 106344 72151 56210 74153 22224 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 433931 66459 230801 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus 103468 19069 445007 70699 234865 110379 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 71951 20970 14735 14734 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 66494 225655 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER 22591 26895 26894 22632 56505 56438 11546 108679 13194 19358 19359 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA 78394 109075 243963 216987 26416 66181 70640 15108 76367 27993 66583 67205 11651 245474 22695 27966 72544 59028 100608 18572 71978 104625 83485 58184 18983 103468 19069 98053 70699 66132 67710 68626 234865 52575 76014 68533 231386 112403 445007 225363 67031 110379 14852 67891 666669 27967 70616 633683 66603 67959 432502 53975 19989 19899 67439 55989 19934 104318 20646 75617 192159 57294 98404 27370 74326 208366 28088 67676 629957 67053 100039316 74097 100038991 75956 66161 68045 67724 666899 66101 66481 68291 230734 225058 229780 66965 66055 67049 108943 68816 328162 69786 100042986 68879 625646 100042740 67418 384091 54633 66069 666609 209357 68219 67248 57905 27207 68479 66642 13872 228005 24128 66467 60321 229512 103677 56417 110532 71281 11810 11811 15382 17749 100043714 23894 64340 233073 53817 225160 386612 73666 68981 72416 54196 104444 53379 75705 71701 13684 30877 229504 67045 237859 66164 20630 69072 76167 53414 26443 14105 26444 56335 19170 76522 230596 19181 19134 70767 57296 72654 56194 69077 244672 66997 66053 18949 67674 238831 77644 223499 71715 213895 78372 100041622 50911 209003 72554 69583 27756 98956 69639 67229 622491 18458 70312 234374 72662 227707 73674 227715 66618 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab 12539 59079 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants 14255 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm 21679 12387 15376 21677 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria 11651 23797 11652 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 14939 100039623 333639 225164 16450 14128 100042305 17242 19165 15208 76580 16449 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand 68240 19891 18538 69745 18969 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 225579 26457 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity 64051 20980 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 209357 23894 98053 67710 66467 17749 100043714 13872 HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation 71951 20970 15442 14735 14734 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d 208624 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation 12558 11816 16709 216197 246228 208659 76453 16007 74761 16011 16010 14734 22027 66557 56047 16779 14161 269181 12321 99571 14118 238055 17283 11806 11807 56453 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions 12552 239096 12387 12564 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase 20230 109620 12387 20740 18810 12367 18772 11797 56702 14957 50708 14083 269582 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression 56406 272322 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling 56438 54473 192656 26410 66589 16178 22030 107607 71966 17874 69721 59025 26443 67245 16177 26444 19170 16179 19181 57296 26395 69077 66997 68652 12234 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression 57230 209357 75316 21429 17749 100043714 625328 433759 13872 269003 23894 319149 78303 66467 319181 319183 15270 319182 50724 60406 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins 233833 12552 15426 16201 239096 227485 230738 12387 12564 20613 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers 11651 227743 56438 19084 19165 100039623 17246 114715 114716 100042305 18148 18015 101809 56716 98053 67710 320207 110135 14161 99571 14939 226849 225849 26931 21770 26932 12539 59079 18673 26372 16449 74126 16590 19047 14170 83379 268980 18708 11682 327826 67605 16367 69162 14235 16542 225164 13016 13649 15208 17532 11774 13380 14184 63953 54519 18646 23797 30955 109689 226861 19354 78781 19247 384783 110279 76007 14025 14366 14368 11491 12988 54721 12047 215114 668218 26403 244373 11610 11652 70297 672511 59069 84035 15234 13191 14388 11839 16450 67160 14178 67529 67112 22084 54167 16476 264064 333639 15184 17749 100043714 433759 76580 12402 51813 14255 12064 12387 26443 26444 19170 12322 17886 12323 19181 21812 108058 109905 12325 57296 26413 17128 26395 69077 26396 66997 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 14675 13001 14688 100039026 67466 14704 14696 14693 12468 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo 211652 16798 12367 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation 14119 14118 16949 16950 16410 50530 23876 13717 21808 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis 380840 73046 100900 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 68652 100039623 100042305 11816 19165 11491 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression 14104 104112 100705 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling 22030 59025 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors 16476 26413 26416 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins 57296 69077 12952 66997 56438 26443 26444 19170 12234 19181 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 13839 100039623 13846 13845 100042305 270190 19165 11772 13838 17395 11771 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 100043508 77219 19215 12408 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation 68981 384091 74326 666609 53379 54196 68219 15382 98053 67710 75956 17749 100043714 27967 20630 68479 14105 70616 66055 56194 24128 67959 233073 20646 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 103468 18854 19069 70699 68097 234865 13649 14056 319149 445007 56455 245688 78303 319181 13427 319183 319182 110379 13424 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib 12539 59079 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions 19247 18613 16410 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 216456 12889 327814 68507 14660 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 14071 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency 13072 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 12502 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism 234724 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification 14675 26416 14688 18441 14704 14696 14693 14678 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate 81600 100043686 GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation 16521 16513 242425 14688 16519 14704 14696 14693 16516 14678 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 12040 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling 15234 14388 260302 12928 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription 17128 11906 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking 75964 76895 67091 53413 74030 76308 76932 14567 69834 11651 224617 224705 53869 260302 67511 72433 67023 93739 70646 211922 78304 68328 72772 76954 66913 11891 19326 69440 70296 229541 72121 16334 68449 60409 320714 78232 216131 245886 56486 50907 75612 73711 108679 22088 67123 208092 26895 66700 26894 110379 11772 11771 28084 104015 210789 217615 218038 68938 74741 20528 233489 16197 73296 69162 12502 58194 17113 13649 20740 54130 17920 21987 20980 69654 29816 252903 11774 232946 56455 14319 108099 20661 13427 14533 117197 245638 23797 109689 13424 72685 19345 67474 104318 68365 68097 14366 22418 215474 207352 105522 74498 67857 66890 215114 68089 66713 74117 14269 20741 11652 80297 70297 56324 56382 13191 11839 16834 20333 22084 16594 228421 99412 26934 13858 16552 16580 17918 73804 16562 12340 76332 16565 56444 76877 12402 75050 54399 67542 72318 97484 14621 118454 14616 20508 19349 54609 60510 11766 11733 17886 17155 238055 241113 12121 18475 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins 320139 26416 76527 11651 56438 12981 16880 17161 17829 14128 60504 21770 18414 15526 54473 19256 16185 100038891 77125 16197 19255 16155 18708 16182 16367 16164 19373 19374 16178 71966 17874 57914 69721 59025 67245 16177 242700 16179 329244 16409 68652 19249 237313 50498 12931 21682 12982 12234 19247 384783 12346 16168 140806 16451 13035 12367 192656 54721 66589 83995 56480 20299 17395 20297 21351 16171 257630 107607 12362 17060 15234 319149 16476 16163 53314 21926 12928 12340 69146 60505 12402 21937 26410 17260 18126 22027 68981 20656 53379 16162 22030 16161 16160 16159 12631 19152 18569 26443 26444 19170 19181 57296 26413 26395 69077 66997 16183 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 18741 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects 242705 21781 13557 211586 12571 17222 68612 68999 56371 12447 668450 66156 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi 17155 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 16476 16451 13819 56438 625328 76580 13001 78303 319181 100039026 15270 244373 233833 67075 58205 57261 12387 226144 26443 26444 19170 19181 20014 57296 14056 103963 319149 69077 245688 66997 108099 21679 319183 21678 68292 319182 241113 69038 21415 21677 13135 12234 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation 66419 50529 100040519 66230 74600 66242 94067 64656 68836 66845 94065 57312 68572 66121 66258 18120 14548 56280 27393 69956 56284 353242 118451 67681 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling 54721 16161 16160 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 68240 19891 26909 18538 69745 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling 109905 11651 14083 110135 54519 14161 12928 12988 99571 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation 67065 218832 70408 66653 71752 17749 66596 100043714 102209 75627 67005 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism 66603 384091 103468 66069 666609 19069 445007 70699 53975 234865 110379 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism 117150 104015 68365 320207 170749 240753 240752 101490 233552 54384 56305 269180 17772 66569 19249 75669 219135 67073 30955 18708 66443 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling 17874 11848 12070 12367 433759 19165 16179 11491 192656 213498 100039623 12366 19418 207212 442801 100042305 277360 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers 72057 14025 66923 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 14381 233833 50493 11651 380975 216456 12861 83409 108099 12862 23797 241113 56716 14751 22084 100041785 11652 14660 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition 12442 14235 12427 56371 268930 30949 71978 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals 17752 17750 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle 59079 14570 84004 380664 330662 16709 544963 98386 104445 624814 56419 26403 18708 94190 13726 19349 277360 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control 66419 50529 100040519 66230 74600 66242 94067 64656 68836 66845 94065 57312 68572 66121 66258 18120 14548 56280 27393 69956 56284 353242 118451 67681 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins 50493 26395 26396 12527 18571 64051 20980 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL 59036 57296 69077 66997 56438 26443 26444 19170 19181 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) 207911 26361 11551 215854 15565 15550 20299 252837 20311 20297 74191 20296 226304 22095 13610 14309 23925 14061 433292 14064 76854 65086 57260 64095 233080 213788 21334 19222 235036 14427 30044 19217 12424 19218 18441 30878 18442 246691 171469 14745 13492 16963 13603 13491 381810 227326 225642 14739 68039 381489 12854 13349 78134 18155 53978 58182 12061 12062 12267 233081 58861 109648 12057 19156 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) 24060 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses 75612 NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response 57296 12021 69077 66997 56438 26443 26444 19170 13194 19181 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants 17532 19047 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion 56417 110532 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement 109828 12279 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 71279 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) 243963 14381 26416 22648 319974 235682 11651 72720 14377 69020 11604 22658 20371 72154 56438 213011 68527 17433 18741 16396 56353 12861 50496 77827 22757 16334 193452 80902 212712 269704 17702 16825 12862 242109 12981 72634 22690 17864 56275 16880 244556 75284 11906 72322 100041785 619310 67005 319944 72180 67065 218832 70408 98053 67710 68626 20833 66464 68776 99730 226182 24074 13716 26931 216456 26379 16449 15378 233833 14312 233107 106931 17222 68612 380975 68999 56371 668450 66156 11727 12578 16179 23797 19247 11863 11652 384091 666609 117150 11864 12362 15278 208595 21415 12447 17863 22084 16476 14460 21781 211586 333639 18131 20926 93736 22761 70122 106298 192119 20656 54196 14102 21933 12064 103988 69263 57748 108961 26413 66494 57913 18996 12366 26909 18538 12427 70088 241113 106344 72151 12905 219022 19367 53325 56187 18854 12021 76367 69260 227743 69131 23988 66813 59092 67338 12227 66262 225655 225182 104625 208836 68240 19891 58184 14088 83409 17246 52679 15257 18983 18148 64058 56716 252870 69181 29813 22427 19718 18534 66923 66653 75605 20823 11835 22337 14815 19401 11816 13001 16590 100039026 67800 23945 14245 13649 18751 219103 53424 108099 229543 71752 70422 66596 75137 71957 77065 16475 102209 75627 71177 69917 22284 22083 209357 68219 21664 74322 74016 103551 75316 228829 434178 23989 217031 237758 12568 13872 208146 54194 67279 14056 319149 245688 66467 319183 17283 319182 74522 15161 243834 50724 14751 233060 60406 11520 57230 264064 17132 50493 56406 241915 20249 68801 216154 80509 170826 12151 21429 15184 17749 22632 100043714 208043 12418 625328 433759 234959 269003 14311 69556 18432 23894 98386 51813 78303 319181 11770 15270 69612 17260 101739 56461 70208 19293 11569 70472 234366 69228 75339 13345 17865 241196 14660 239652 192292 235028 94223 22709 109648 78251 21388 675812 18091 12387 29808 26443 21423 26444 12326 19170 12322 12323 19181 108058 12325 57296 17128 12477 69077 68744 66997 22693 21679 21678 12571 16183 272347 434377 26380 619331 21677 12579 244216 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria 56455 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling 384783 16367 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation 272428 107146 435528 233801 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency 12040 12041 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 56480 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms 16476 241275 13057 22418 14369 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants 14255 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 22788 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR 68240 19891 26909 18538 69745 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 17001 72303 56448 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) 20202 12229 17087 21898 20193 110135 17874 14161 99571 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand 170743 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 72057 14025 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling 14573 384783 19247 14388 18749 13448 18708 623279 327826 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins 56386 14537 272411 140474 171212 20442 78754 108760 212996 20443 71685 17829 20440 53625 20447 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation 66240 16535 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses 54721 230398 16451 56438 230073 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria 11992 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 18131 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization 12229 22165 19056 229709 16428 21682 234779 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA 21664 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation 171281 73724 74156 97212 26922 52538 72482 56360 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells 57296 69077 19696 66997 18037 26443 26444 18751 19170 12234 19181 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 233833 192119 94223 67710 68626 17749 100043714 625328 11727 53424 319149 78303 319181 319183 15270 319182 72634 17864 75284 72322 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI 77582 225845 IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs 26413 16451 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction 21956 21916 21954 50875 22138 17896 59069 21957 17868 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR 276846 329777 CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport 353169 20537 64452 20528 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 238055 17777 11813 11814 11816 11806 11807 56453 11808 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase 12442 68097 381318 71978 18221 226747 108000 103468 13006 70699 20843 12615 234865 66570 218914 208092 100088 66700 625534 445007 22151 66468 238463 110379 226849 228421 225849 26931 21770 26932 73804 380664 98386 19047 232987 17222 68612 68999 668450 26443 26444 66156 19170 22142 19181 216965 57296 69077 56455 66997 66977 13427 13424 13726 57294 102920 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 225058 633683 432502 225363 100042986 19989 625646 100042740 19899 14852 19934 18458 75617 57294 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors 225642 381489 68039 12854 13349 207911 18155 26361 58182 12061 12062 20299 252837 20311 12267 20297 20296 226304 109648 23925 14061 433292 14064 76854 19156 21334 14427 12424 30878 246691 171469 16963 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses 19090 214763 446099 22040 56480 268857 20821 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins 103468 241915 19069 20230 70699 12151 234865 22658 12418 433759 445007 212712 110379 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome 18439 12362 66824 67955 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 17128 94187 245688 170826 433759 234366 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 53945 15203 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex 209357 23894 98053 67710 66467 17749 100043714 13872 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 16590 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction 17921 109791 225600 11813 11814 11816 18587 19892 67442 71951 20970 19674 14735 14734 12057 237178 77974 241452 238055 14688 216454 18107 235033 11806 11807 11808 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 68421 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle 54004 23912 109711 56419 14270 84004 223254 66898 18708 19349 223870 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA 433759 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation 17128 94187 245688 170826 433759 234366 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases 12442 71909 28135 17997 214444 56438 71978 15366 108000 21664 12537 268930 13557 629959 17865 14235 56371 76816 26443 26444 54130 30949 219103 19170 22142 68475 19181 69654 18536 57296 208518 381644 69077 56455 66997 236266 13427 99100 12427 214552 103733 13424 219072 16475 104318 51885 12234 233276 16328 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway 26413 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade 225600 14688 18107 237178 19674 18587 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions 80879 20737 66053 83995 11931 16728 26570 11933 50934 20540 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis 22275 15288 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 109333 11651 14257 16542 227743 18613 18749 12387 19084 19087 14688 54409 14704 18442 14696 14693 56716 63873 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation 18293 14711 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis 104015 218038 13858 14366 22418 12402 233489 215114 16197 68089 66713 74117 14269 20508 54609 60510 12502 58194 17113 56324 13649 108679 20980 29816 26895 26894 238055 11839 109689 72685 19345 11772 11771 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 233833 94223 12064 17433 433759 12326 12322 16179 12323 108058 12325 98386 17260 19293 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 26416 108099 241113 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System 75409 18749 214579 19084 12293 12287 19087 20168 54376 19418 17246 16535 216028 74342 26556 228836 245537 17161 791260 11444 14688 223604 238076 14704 14696 14693 16499 11771 16497 192775 241794 16539 16502 140492 216456 12889 327814 68507 58802 52150 240444 72258 106025 16530 16526 16533 16528 216963 386750 238276 207565 20508 14660 60510 16519 110637 14658 22343 140493 14809 328699 14645 16516 18751 12326 14402 17920 12322 14397 14678 12323 242274 20980 108058 11447 12325 170483 26413 16521 16513 12846 242425 14409 108099 14408 231252 64011 241113 110304 245450 272381 239250 16500 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse 12502 19260 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 18207 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine 78303 57321 319181 319183 21750 15270 319182 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR 100039623 100042305 19165 11491 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination 14160 329252 407821 14366 14368 192199 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 55961 20515 107723 20536 13521 20516 320718 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors 11651 67738 16204 16592 17393 22236 11652 17395 98053 13006 13610 20843 67710 14228 67484 268903 100041004 12390 18534 104263 319149 11839 14688 319183 319182 14704 218214 14696 193796 14693 17863 20698 16476 20249 22632 17749 11813 100043714 19401 11816 625328 433759 99982 14104 78303 319181 15270 268980 18708 233833 26876 13649 14678 26413 100043508 241452 242285 105014 12903 11812 216454 14083 23797 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events 19056 14686 207911 18749 19084 19087 11551 20311 20297 74191 20296 226304 626596 13610 19049 387512 67792 12568 433292 76854 65086 14675 106512 14688 14427 19218 14704 30878 14696 67839 14823 14693 171469 14745 13603 13491 381810 227326 14739 56533 229709 83771 12854 21770 387356 18155 53978 574417 387347 57253 12061 57254 12062 387355 387342 387349 387616 18573 207565 12267 387513 14687 110326 109648 12057 12326 12322 14678 12323 108058 387353 12325 26413 387515 353148 242425 19156 353165 387348 18798 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME 18534 75894 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle 21781 13557 211586 17222 68612 68999 56371 668450 66156 242705 22589 12571 12447 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT 226849 212398 225849 26931 21770 11651 26932 14366 22418 14368 56438 625328 433759 20377 13001 12006 78303 319181 100039026 15270 68031 11652 100683 13016 56505 12387 26443 20890 26444 84035 19170 192199 19181 59036 57296 14160 13380 319149 69077 329252 66997 407821 20675 319183 17283 319182 21415 12234 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 12442 217718 59126 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry 21781 11651 211586 629959 56371 26443 26444 19170 20459 19181 57296 69077 66997 12427 23797 12447 11652 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 17060 20866 12229 269717 229709 58194 234779 18708 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants 226849 225849 26931 21770 26932 12387 GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib 14385 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions 227394 108115 101488 20502 58807 28253 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis 26416 11651 18749 19084 19087 21808 22138 16410 234779 11537 320202 21922 320207 67059 110135 11818 14161 21687 18613 27359 58992 11602 19039 109821 71946 20720 22388 14058 12321 14061 18755 74840 14071 66866 99571 14064 20866 269717 104418 19222 18441 11806 331374 226849 225849 26931 21770 26932 269060 217480 270152 12512 20597 11931 11933 18708 23945 12527 18751 18407 16409 19156 16000 14083 54519 30955 109689 19354 16784 19247 18815 230398 16621 11551 12988 71951 20970 109711 83995 16728 14735 105722 17075 14734 18439 110891 20541 12568 67972 192176 11941 14675 15234 67299 319149 16002 14688 14704 14696 14693 17863 16594 16923 228421 14460 26934 67414 16552 16580 73804 11640 78287 22761 11848 22762 625328 16562 433759 12928 15353 330662 12340 12523 170731 23984 16565 58802 75050 18573 17133 241489 99982 16533 14726 106722 217837 22068 18438 18126 21933 12631 19152 26570 50934 20540 14678 109905 72017 26413 80879 66053 20737 238055 20344 18106 12481 18792 20194 20725 20719 18791 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex 226849 225849 26931 21770 26932 HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 109075 14381 26416 70640 66583 11651 72544 56438 12861 12862 100041785 103468 382056 19069 70699 234865 15926 228775 445007 110379 233826 27060 225849 66144 15526 12034 242341 11964 233833 70461 17222 19377 68612 380975 68999 56371 668450 66156 12578 633683 100043508 23797 75617 57294 27370 629957 100039316 100038991 66481 225058 11863 52466 11652 21351 27207 71389 11839 12447 20821 16476 21781 13557 211586 13819 12340 106766 20459 56444 57321 21750 67204 26905 219158 29810 18415 108664 72630 56354 50497 22791 20656 17087 21898 100041766 12013 26570 75766 26427 12913 26413 238055 12427 56453 50932 26921 101148 17872 277854 71765 230676 68240 56702 19891 14957 50708 83409 26408 17246 66403 74142 50907 53417 98402 28146 56716 71962 78943 319481 29806 67305 15364 68090 14228 268903 58233 14950 56032 100043858 12580 11806 11835 14815 74126 13001 69065 100039026 67605 69162 67891 666669 13058 13057 17436 54130 69654 56455 432502 13427 19989 13424 19899 16475 19934 12234 68097 666899 100042986 625646 100042740 213539 67248 74322 56445 14056 18104 242705 319149 13191 245688 319183 319182 50493 56406 241915 12151 12418 625328 14583 78303 319181 15270 17260 21881 22027 11927 26443 26444 19170 12322 12323 19181 108058 12325 57296 69077 66997 12571 50911 69639 72662 12579 227715 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants 14255 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection 74326 227743 75956 214763 217303 22174 20168 71951 66055 20970 68816 68879 75669 17069 14735 230861 22083 56716 17395 14734 67418 384091 213539 54633 666609 68219 98053 67075 56445 67710 18571 57905 68479 66642 100732 14061 22088 15569 319149 16834 319183 18107 60321 319182 231380 16649 11806 74153 17713 11772 11771 15382 17749 100043714 14104 78303 319181 64340 233073 18708 68981 19766 192292 54196 12737 17087 53379 21898 13684 27967 12387 12259 12322 70616 12323 108058 216965 12325 20014 103963 67959 100040603 68292 69038 67439 19899 13135 18458 20646 192159 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN 19762 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress 109333 11651 14257 16542 227743 18613 18749 12387 19084 71978 19087 14688 54409 14083 14704 16410 18442 14696 14693 56716 63873 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology 12326 433759 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX 14058 14071 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism 27370 50493 629957 100039316 100038991 20768 666899 105148 66481 225058 21743 100042986 13722 211006 625646 100042740 14711 65967 67891 67248 666669 27207 75420 633683 432502 269378 19989 19899 19934 12411 75617 57294 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS 12064 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages 11839 16779 14178 16773 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli 109333 11651 14257 16542 227743 18439 18613 18749 12387 19084 71978 19087 58226 14688 54409 14083 14704 16410 18442 14696 14693 56716 63873 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching 19687 19718 18538 69745 106344 72151 69263 18969 REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling 19766 22030 100041766 21926 432940 66552 76580 11797 73218 106025 21937 11796 56480 22195 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 209357 23894 98053 67710 66467 17749 100043714 13872 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion 18845 12631 18844 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly 319149 78303 319181 319183 15270 319182 11538 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 14388 11651 12539 59079 76890 23797 11848 13649 18708 17179 11652 20459 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 233833 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface 11927 72621 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 77974 17921 241452 216454 235033 19892 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 21781 211586 18969 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes 12442 13001 100039026 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions 12229 620235 234779 18708 668101 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 319944 209357 98053 67710 17749 100043714 66464 68776 99730 13872 23894 226182 66467 24074 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling 12539 59079 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway 320139 384783 19247 16451 56438 19671 57437 70178 226016 12988 54721 83409 19418 114715 114716 26403 12981 320484 69601 18015 101809 54153 20741 80297 110135 14161 21687 70727 99571 15234 56705 11839 14178 67112 226849 225849 26931 21770 26932 18673 14573 16590 19047 16185 14255 14170 83379 18708 327826 16367 13649 20740 26443 26444 19170 12322 12323 19181 242274 108058 109905 12325 57296 17532 26413 26395 69077 26396 66997 63953 14083 54519 16183 109689 208884 12982 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 14381 50493 11651 56438 13001 100039026 21881 11652 21351 15926 12013 26443 17436 26570 26444 19170 19181 57296 18104 71389 69077 11839 66997 23797 233826 20821 12234 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells 228421 19025 26934 68097 73804 54130 12340 69654 56444 13036 13191 56455 56464 15001 13427 13424 16594 19349 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 18088 18012 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 12952 104318 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression 57230 209357 75316 21429 17749 100043714 625328 433759 13872 269003 23894 319149 78303 66467 319181 319183 15270 319182 50724 60406 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 238505 14467 14570 13830 19349 12988 GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation 333639 12387 26443 26444 19170 13838 19181 13389 17128 57296 56184 69077 66997 21679 100038891 16869 18999 15376 18510 21415 22771 17863 21677 20613 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport 353169 20537 64452 55961 20515 20529 53945 20516 15203 18400 24060 107723 20544 27376 13521 110891 20541 20521 13723 104245 216227 269346 107566 71279 225579 243328 170756 20528 20536 105243 110895 226999 71803 28253 68682 26457 227394 72621 76257 22784 26570 230810 50934 72002 20540 80879 330064 70484 67473 67582 108115 75750 101488 20502 237831 108652 58807 320718 20538 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling 12631 11848 19165 17886 13838 13839 100039623 216963 14083 13846 13845 68089 77579 100042305 270190 66713 74117 11772 11771 17395 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation 57748 17246 219022 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 12447 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins 76007 13858 625328 433759 18554 13001 99982 78303 319181 100039026 20901 17246 15270 13345 75339 20613 233833 192173 56805 16601 18746 114142 13016 12387 26443 21423 26444 19170 19181 20014 26413 57296 14056 103963 319149 69077 245688 66997 14376 319183 319182 69038 15376 13135 53325 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA 103468 100088 19069 445007 70699 234865 110379 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) 98386 235293 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 241915 14056 21781 245688 211586 12151 22658 29808 56353 225182 50496 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling 13176 22068 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 57296 26416 69077 66997 56438 26443 26444 19170 12234 19181 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development 12326 433759 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm 13389 57296 56184 69077 66997 333639 12387 26443 26444 19170 13838 19181 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 22658 54644 56438 107260 360216 246179 24060 243853 67843 212712 75847 228366 103468 19069 70699 234865 108138 14161 14058 14061 14071 99571 21826 140474 66548 445007 330267 207596 224697 223838 20356 110379 17829 18636 233826 230073 234847 68612 59025 633683 58222 20014 103963 14376 68292 15007 109689 69038 19340 19345 20387 13135 12982 75617 57294 27370 629957 100039316 233870 66481 19671 26374 225058 192656 107895 70560 230577 224805 20442 70120 67417 20390 623661 20443 212919 276846 22210 170745 64931 246190 20440 114654 72194 17068 15204 237847 20447 11650 22209 68468 14756 14734 22195 230801 68404 433931 21684 67075 231670 21683 226541 56047 107607 66459 103534 329777 108687 69754 71003 269181 77113 269295 27207 217337 67615 27058 207952 74653 231672 14537 272411 14675 101358 171212 24128 78754 16553 68098 108760 55946 14794 212996 14688 214931 71685 22151 217217 80294 67466 117589 226982 238463 74646 14704 233902 14696 231380 12447 83962 14693 30838 20698 12468 99412 66174 17918 54613 13819 11848 57170 69080 234730 108853 17720 76332 76877 54399 67542 97484 75452 68031 50798 19766 75705 22030 13684 100041766 216150 432940 21812 238055 12427 22224 56453 636544 15108 53413 69834 53869 67511 66855 66913 16588 68043 239706 67895 72096 70511 14479 100039623 67151 53380 100042305 66537 22217 74270 71472 217057 69641 30940 19025 235323 327799 13006 319651 20843 268903 108679 12321 13194 19358 19359 22591 26895 26894 225363 53625 11806 14852 11807 27979 11808 56347 223691 16341 13685 22333 217615 231093 237930 11816 244071 320244 238328 67269 320011 226841 74126 22644 66435 75841 66967 66597 77125 69162 67891 666669 13016 17448 432502 19989 19899 19934 11847 68365 67422 666899 11551 246228 208659 76453 16007 16012 74761 16011 100042986 16010 17069 12945 625646 100042740 22083 208624 67003 19329 76338 53868 110265 67248 56386 13191 381903 16834 66419 50529 100040519 66230 74600 66242 94067 64656 50877 68836 66845 94065 57312 545260 68572 66121 66258 18120 14548 56280 27393 13722 69956 56284 353242 118451 67681 66399 22027 233081 19090 233900 68366 320311 108089 103737 67674 230075 67091 76308 26938 260302 72433 68328 11891 19326 16334 60409 624814 78232 18293 216131 17342 271970 269582 17705 74776 269951 18442 225642 17711 14422 18010 14276 15526 14607 12591 17721 17722 69082 66632 17719 69740 13494 105638 56373 18970 12876 16790 76703 57394 16325 12873 13809 16000 67475 11421 67711 67241 55989 21974 67872 100038991 105148 12558 67196 226153 22321 353172 66590 107271 110960 16002 11839 67160 20333 57743 12340 56444 13036 22335 67204 26905 13667 209354 19349 11733 17155 66494 18538 223499 56187 18854 12021 69260 17246 74142 50907 53417 18148 28146 252870 22427 100683 216825 56505 218214 54638 66498 59043 233805 73828 234664 66199 242418 74251 415115 11835 22337 14815 19401 229615 16709 216197 13001 68396 16432 100039026 20660 70423 232670 20219 69592 20740 54130 22142 69654 56455 13427 13424 104318 12234 223870 18815 68097 17228 13035 215474 207352 105522 74498 11504 67857 66890 22284 83995 20741 80297 16779 56324 14118 56382 319149 245688 319183 17283 319182 15161 241915 20230 12151 22632 12418 625328 14583 433759 19703 245847 56174 11797 11796 78303 12006 319181 17309 15270 66557 12387 26443 26444 19170 19181 57296 17128 69077 66997 18458 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 17132 11651 170826 11835 14815 56438 68527 26443 26379 26444 19170 19181 26413 17128 57296 69077 212712 66997 17702 23797 56275 13345 11652 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress 14381 50493 56406 11651 56438 106766 12861 20459 13001 100039026 12862 21881 100041785 11652 21351 67305 20656 11927 13058 380975 13057 14950 15926 12013 26443 17436 26570 26444 19170 19181 57296 18104 71389 69077 11839 66997 23797 233826 20821 12234 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling 54721 329244 19247 237313 16451 16155 242700 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles 101739 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly 66603 384091 103468 66069 666609 19069 445007 70699 53975 234865 110379 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs 233833 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors 58992 109821 16621 14071 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling 16163 16182 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins 21826 11504 66548 330267 207596 224697 223838 80294 20356 18636 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 22589 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis 57296 69077 66997 26443 26444 19170 19181 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG 99010 66586 237625 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter 67065 218832 70408 71752 17749 66596 100043714 67005 INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion 105722 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network 226849 19247 384783 225849 26931 11651 21770 26932 16334 16590 77125 15937 14255 14170 83379 268980 18708 98432 327826 11652 16367 117150 320207 17874 12064 13649 228775 16179 26413 15234 14388 11839 14178 67112 23797 30955 19354 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation 20459 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation 27370 67891 67248 629957 100039316 100038991 666669 666899 27207 66481 225058 633683 432502 100042986 19989 625646 100042740 19899 19934 75617 57294 KINESINS%REACTOME%R-HSA-983189.5 Kinesins 228421 75050 26934 16552 16580 73804 16562 16594 16565 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 50493 18104 71389 12013 26570 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum 18131 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R 19247 384783 228775 14388 16000 16002 75669 14178 67112 14170 14255 83379 18708 327826 11652 16367 18576 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations 107146 13479 71773 13123 13122 23827 18984 75475 66112 11863 13849 14598 100042314 17161 436059 22236 13072 232087 110115 435528 29859 11864 631304 55990 213012 56615 272428 66447 269378 64385 74134 57344 14871 94215 69065 233801 238505 72303 319655 56448 26876 76263 100043508 56050 12846 552899 67674 70484 20860 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling 57296 69077 11651 66997 56438 26443 26444 19170 19181 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC 12651 13001 68682 237928 56018 106861 100039026 14245 212862 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival 13479 26416 229709 12502 14687 58861 18749 19084 19087 17886 11491 14678 14688 14598 14704 14696 234779 14693 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta 19766 22030 230398 71966 100041766 23988 54644 69721 16396 11793 56480 230073 74153 80861 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints 26416 228829 59092 56438 26443 26374 26444 19170 19181 57296 69077 66997 17246 12427 12447 12234 29813 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade 225600 14688 18587 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint 228829 59092 26443 26374 26444 19170 19181 57296 69077 66997 17246 12427 12447 29813 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 14675 26416 14688 18441 14704 14696 14693 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 19299 56050 17117 26459 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy 108099 241113 11520 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS 29873 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation 16519 328699 16516 14402 14678 14397 16521 16513 242425 14409 14688 14408 14704 14696 14693 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 19247 17087 21898 56480 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription 264064 51813 333639 15184 56438 433759 15208 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 16476 209357 98053 67710 69131 17749 100043714 20833 13872 208836 23894 14088 66467 13716 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors 110637 14809 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 27370 16341 629957 100039316 27207 66481 225058 633683 67204 26905 27979 75617 56347 57294 223691 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer 226849 13380 225849 26931 21770 26932 14366 13016 14368 12387 84035 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels 16521 16513 242425 14688 16519 14704 14696 14693 16516 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 57296 69077 66997 12427 26443 12447 26444 19170 19181 20459 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation 56187 68365 76308 69834 53869 72433 68328 11891 19326 76877 58222 56382 19340 19345 19329 76338 19349 53868 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade 667277 12944 12259 239447 14061 17221 56373 12902 93721 109828 12260 11537 12279 12267 14962 12262 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants 226849 225849 26931 21770 26932 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 56448 631304 74134 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation 27370 16341 75705 629957 100039316 13684 27207 66481 225058 633683 67204 26905 27979 18458 75617 56347 57294 223691 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells 18088 16334 11651 23797 103988 15376 18012 18609 11652 378435 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 14184 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease 14388 14184 18708 327826 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis 13006 140557 20843 50878 56739 77053 78303 57321 319181 319183 21750 15270 319182 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ 26413 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 14688 14704 14696 14693 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding 207911 319757 54409 215854 15565 15550 93896 74191 226304 56089 13610 51801 387512 22421 23925 20890 14061 433292 14064 76854 65086 381853 57260 64095 233080 213788 22410 21334 19222 235036 14427 30044 19217 12424 19218 18441 30878 18442 246691 14823 171469 14745 20287 16963 13603 381810 227326 225642 14739 68039 381489 12854 13349 387356 78134 18155 53978 210198 58182 12061 12062 14607 58861 12057 19156 14366 26361 22418 14368 14369 11551 20299 252837 20311 20297 20296 22095 14309 14688 14704 14696 14693 13492 13491 83771 574417 387347 57253 57254 387355 387342 387349 387616 12267 233081 387513 110326 109648 387353 387515 353148 242425 353165 387348 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis 93683 195646 71951 20970 83398 70484 50786 14735 14734 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation 12442 98386 380664 71978 13726 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking 73130 30930 22419 22410 22418 22421 20890 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 12229 245880 12502 17909 17918 330319 105855 22376 12928 242687 330662 17886 26413 14083 68089 66713 329165 74117 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis 229709 12502 234779 18708 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 12571 12578 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 14058 14061 14071 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones 21990 13370 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases 16476 99412 20656 12568 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 67112 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis 16476 56406 15400 15410 22658 22632 103889 17749 15407 100043714 19401 625328 104625 58184 78303 319181 15412 15270 67710 14056 319149 245688 319183 319182 15399 16475 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade 16476 12229 26416 21770 192656 26410 66589 17260 20202 17087 21898 22030 20193 107607 110135 71966 14161 17874 26940 69721 59025 67245 16179 99571 26413 26395 68652 12234 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling 16185 16451 16183 12981 18708 12982 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript 103468 19069 445007 70699 13684 234865 110379 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions 192897 16779 16773 12822 16410 Statin pathway%WikiPathways_20260910%WP1%Mus musculus Statin pathway 16971 11814 11813 15450 11808 13350 16956 20778 18830 16835 11303 13122 15357 11806 20652 16816 17777 11812 11816 IL 9 signaling pathway%WikiPathways_20260910%WP10%Mus musculus IL 9 signaling pathway 20851 384783 12702 20848 26395 16451 16186 54721 26417 11651 20846 16367 18708 81601 16199 19247 16198 20850 14784 269523 26396 20416 16453 26413 Cholesterol biosynthesis%WikiPathways_20260910%WP103%Mus musculus Cholesterol biosynthesis 18194 110196 208715 66234 20775 319554 192156 13121 15357 13360 68603 235293 14137 16987 17855 Selenium metabolism selenoproteins%WikiPathways_20260910%WP108%Mus musculus Selenium metabolism selenoproteins 109815 107585 107869 223776 232223 214580 20342 80795 27361 13370 20687 19946 65967 14778 625249 50880 26462 69227 75420 71787 18986 20768 71984 75512 19697 14080 14281 28042 20363 13371 72657 20226 50493 20683 211006 109079 12916 14775 114679 20341 20364 280621 18024 14776 16476 18033 74777 TGF beta signaling pathway%WikiPathways_20260910%WP113%Mus musculus TGF beta signaling pathway 21814 24136 21803 55994 16451 26420 17125 12393 21815 20481 17128 12159 21926 14313 14225 20750 22408 21813 21825 16878 18121 16842 13805 17130 20482 94187 26417 12399 21812 18033 17127 68010 328572 18787 16323 268977 17126 20848 230597 15978 16476 17131 14106 15461 12387 14281 209446 13645 20846 12914 17129 16420 Hedgehog signaling pathway%WikiPathways_20260910%WP116%Mus musculus Hedgehog signaling pathway 14632 24069 13548 16147 14451 268697 19207 13363 12914 12534 14634 15245 19206 20423 16002 20481 19335 269209 319757 20220 14633 20466 Glucuronidation%WikiPathways_20260910%WP1241%Mus musculus Glucuronidation 216558 109785 226041 66681 15275 22235 72157 394433 613123 72094 71773 100727 394430 94215 394436 552899 22236 Non homologous end joining%WikiPathways_20260910%WP1242%Mus musculus Non homologous end joining 22596 14375 19090 17535 108138 75570 19360 75570 EBV LMP1 signaling%WikiPathways_20260910%WP1243%Mus musculus EBV LMP1 signaling 26406 18034 26419 21926 19697 67399 71609 15977 16150 22034 12675 26409 18033 16179 22029 20304 53859 12675 16151 20297 26413 15519 Estrogen signaling%WikiPathways_20260910%WP1244%Mus musculus Estrogen signaling 15182 26420 13871 24074 99730 20466 26413 17420 12443 229906 12043 69920 15183 13872 13982 12912 18706 328572 16150 20185 245841 231329 18747 20021 66464 12572 16476 14683 56233 12189 11651 74197 15185 102216272 108143 66420 14885 14884 14688 235459 68153 20779 15461 68705 16151 20022 20662 109880 26395 26416 18033 13712 216148 433759 21343 21374 17749 12914 76854 14281 69833 14784 16202 23894 226182 14699 67710 15184 70315 208727 209357 20020 66671 20683 12675 Transcriptional activation by Nfe2l2 in response to phytochemicals%WikiPathways_20260910%WP1245%Mus musculus Transcriptional activation by Nfe2l2 in response to phytochemicals 18750 26419 231872 12608 18024 50868 14629 15368 17132 13844 18706 14858 18104 14630 Methylation%WikiPathways_20260910%WP1247%Mus musculus Methylation 11720 232087 22017 18948 108645 140483 21743 18113 12846 Oxidative phosphorylation%WikiPathways_20260910%WP1248%Mus musculus Oxidative phosphorylation 75406 66043 228033 17992 595136 66218 227197 66091 11951 66916 68198 17705 407785 66377 78330 67264 68375 68202 230075 67273 66108 28080 66416 11950 68197 27425 17705 17706 17993 17720 407790 67942 68342 14939 71679 68349 72900 17721 17718 17991 226646 225887 54411 66046 67126 11958 11947 17716 68055 11957 70495 57423 67130 17722 69875 11946 17995 17719 17717 EPO receptor signaling%WikiPathways_20260910%WP1249%Mus musculus EPO receptor signaling 13857 16452 20779 30955 14784 13856 20416 228026 20846 26417 26395 26396 11651 26413 12703 20851 12700 20850 20848 19264 19273 110157 20662 384783 16367 218397 Arachidonate epoxygenase epoxide hydrolase%WikiPathways_20260910%WP1250%Mus musculus Arachidonate epoxygenase epoxide hydrolase 13850 12858 12868 13850 Metapathway biotransformation%WikiPathways_20260910%WP1251%Mus musculus Metapathway biotransformation 13120 64580 14860 110198 70646 69083 394433 17961 394433 56050 104086 17423 71519 14263 83398 50785 14872 72054 81906 15476 211666 15478 320997 14775 60322 22017 107146 140483 12012 14262 76969 14857 13081 53374 394430 56362 394434 13116 102294 56441 14865 14776 110115 394436 13077 11677 195646 269854 14778 13078 14873 77951 74134 20860 13075 13079 546726 20859 50786 13115 232174 14871 58810 14261 67877 552899 21743 18113 68312 545817 98956 58250 71367 330217 13122 14874 54371 13107 53897 319415 76263 545276 23908 13124 13076 14782 29859 50787 13072 14866 552899 15531 16497 67553 71797 13123 13070 72094 98388 69083 13849 66176 269642 20887 72117 628779 625249 244209 54710 54200 545963 14854 14780 13850 56773 14862 16499 55990 14859 16498 70999 226564 13082 13106 72136 73671 328779 13074 26887 56615 67861 68396 94284 14858 14870 12846 22236 66447 208665 68214 14866 381334 68947 13121 59031 Amino acid conjugation of benzoic acid%WikiPathways_20260910%WP1252%Mus musculus Amino acid conjugation of benzoic acid 107146 60525 Type II interferon signaling IFNG %WikiPathways_20260910%WP1253%Mus musculus Type II interferon signaling IFNG 20847 15978 20846 20375 16391 15900 16452 16451 17329 12703 13058 19247 15894 16363 15980 14468 21354 15979 97122 15977 16176 19106 100038882 18126 16362 15945 16912 12702 18753 16364 15958 12265 19692 Apoptosis%WikiPathways_20260910%WP1254%Mus musculus Apoptosis 58801 12371 17246 12018 22031 16362 18033 14102 11797 66593 11651 14940 94185 12015 18035 12362 19766 16363 18036 16992 12363 54139 12367 18646 21937 16001 19697 12675 12028 11783 21938 11796 12122 85030 26414 22029 16150 27056 13347 54131 12366 12123 22062 72193 12369 17869 21926 16002 12905 16151 51800 22030 12633 12050 18708 71609 11799 16000 21933 16476 12177 13368 12043 54123 12048 16364 18037 22059 26398 12370 11798 14103 22035 15201 14082 17210 12368 12125 26401 22061 Nod like receptor NLR signaling pathway%WikiPathways_20260910%WP1256%Mus musculus Nod like receptor NLR signaling pathway 59079 12675 16151 19697 26419 13844 26409 16150 21939 Mismatch repair%WikiPathways_20260910%WP1257%Mus musculus Mismatch repair 16881 18971 17685 19687 17688 17350 26909 18538 68275 Homologous recombination%WikiPathways_20260910%WP1258%Mus musculus Homologous recombination 67967 19361 12190 68275 27354 19365 69745 11920 623474 17535 18971 68275 18972 19360 Retinol metabolism%WikiPathways_20260910%WP1259%Mus musculus Retinol metabolism 63857 63954 11668 320092 19401 19378 67470 77974 19682 20148 232174 237636 56847 27409 16956 13106 19892 170752 20778 54200 545963 79235 20182 98711 67442 19659 20181 26876 20887 13082 12491 19411 235033 11522 20183 12904 12903 19771 19660 19662 218772 ErbB signaling pathway%WikiPathways_20260910%WP1261%Mus musculus ErbB signaling pathway 216148 56637 83961 320207 13869 23797 18803 12223 26419 13867 211323 13649 13866 11836 12015 11839 14388 13712 21802 20662 20779 14784 18183 13874 17869 20850 12575 26395 16476 15200 13645 13685 12928 18750 12576 12322 56717 15461 80794 70584 17973 26400 26413 14083 11350 100042150 Aflatoxin B1 metabolism%WikiPathways_20260910%WP1262%Mus musculus Aflatoxin B1 metabolism 110198 13077 14871 14862 13849 Mitochondrial gene expression%WikiPathways_20260910%WP1263%Mus musculus Mitochondrial gene expression 21780 15161 224481 15278 226169 66410 545725 14390 216151 26379 18181 213054 20683 19017 170826 17876 12326 12912 19055 Estrogen metabolism%WikiPathways_20260910%WP1264%Mus musculus Estrogen metabolism 12846 94284 13077 394436 20860 20887 18104 13076 394434 14857 22236 14862 13078 Polyol pathway%WikiPathways_20260910%WP1265%Mus musculus Polyol pathway 16548 230163 11677 20322 SIDS susceptibility pathways%WikiPathways_20260910%WP1266%Mus musculus SIDS susceptibility pathways 20271 11516 16153 21990 17161 20683 15205 12268 19712 15550 212139 13018 18095 20191 108015 21926 328572 625018 14461 16511 13195 12391 11998 11517 19017 170826 16917 11438 18044 16535 17172 19883 54006 15558 22355 13798 16193 22608 14462 22354 216343 15567 217946 15510 18992 260298 230857 14695 11835 14235 16194 12912 16535 14815 11859 19713 15208 27140 18033 18088 18935 11444 Fatty acid beta oxidation%WikiPathways_20260910%WP1269%Mus musculus Fatty acid beta oxidation 97212 11364 231086 66853 12896 11409 13177 93747 270076 15107 231086 11370 14571 433256 13382 60525 21991 14626 14081 67460 15450 57279 11363 12908 16890 216739 12894 12895 50790 14933 67717 12651 110446 74205 16956 Endochondral ossification%WikiPathways_20260910%WP1270%Mus musculus Endochondral ossification 11647 20750 14184 17386 11595 12166 16147 14182 16002 12161 16000 67760 21803 12283 17260 12824 23794 12399 19226 14172 12313 20259 12393 14173 20679 19206 18605 18747 16568 58250 13039 21808 11651 14634 208715 22339 17395 12406 12162 12577 20682 21833 20846 11504 14600 18792 17313 20851 12813 240913 16001 21821 18214 12020 58214 20378 18791 208727 19227 19228 20678 21859 Selenium micronutrient network%WikiPathways_20260910%WP1272%Mus musculus Selenium micronutrient network 14775 19215 11689 17708 14782 103711 19223 64292 21391 17769 98256 14776 56473 20363 75512 80795 22436 238505 76267 17709 12359 14778 625249 Folic acid network%WikiPathways_20260910%WP1273%Mus musculus Folic acid network 64292 19223 75512 56473 12411 26462 12359 17769 98256 14776 19215 80795 20364 14778 238505 11689 27361 14782 22436 50493 103711 14775 625249 Oxidation by cytochrome P450%WikiPathways_20260910%WP1274%Mus musculus Oxidation by cytochrome P450 13082 66427 72017 320997 109672 13078 266690 123956256 320635 110115 13115 72054 546726 13121 13123 13075 13079 232174 13122 545817 13124 74134 56050 244209 13116 13120 13077 102294 71519 81906 13106 13070 77951 18984 13074 104086 13107 109754 13072 13081 13076 GPCRs non odorant %WikiPathways_20260910%WP1396%Mus musculus GPCRs non odorant 14829 56696 99633 108068 18387 17201 12769 19218 208188 12777 12614 54393 18168 15558 20132 70839 54140 13051 11551 58861 15566 18441 67168 19228 319430 13349 225192 387349 14293 11555 14427 15465 17202 107934 14766 22354 20607 14365 57385 16867 19216 14367 12771 12000 114229 217369 13489 242093 15562 12672 57252 18430 213527 69296 11542 18442 140741 12311 99633 242425 20605 93746 13490 57253 387285 20608 18216 230777 12671 19214 22045 111174 14816 107221 94226 244701 319757 12669 14309 230775 110168 107831 18167 210198 12922 18101 69412 78826 14744 54598 13492 14652 246313 13610 11554 57265 11517 15557 387616 211578 11552 11607 99296 108073 11539 14602 15564 19220 381853 14370 387344 387355 210933 12773 319239 13491 18386 574402 53883 11608 13617 140795 320463 12273 65086 14368 216749 14062 229214 11609 59289 667992 53978 11549 233571 213439 21338 381489 238377 11541 15565 12801 140498 70086 170757 11540 12770 12061 14739 15560 233079 233080 233081 18217 12921 387353 17200 15563 26364 93896 12425 14428 232431 330814 12458 104443 57260 54199 13611 22355 14823 12776 14369 12802 227288 239283 387515 84112 22095 14371 71223 14064 14767 213788 13618 23796 17171 108069 14063 381810 12426 12765 12767 11550 11556 12775 12766 57811 387347 574417 226304 12768 20609 19222 52614 21336 237175 14715 23832 13733 80901 319229 12267 11553 18390 319387 236781 14745 19065 268934 14065 12145 13603 80885 243764 74191 353167 17773 26361 227289 19204 16995 15551 239336 12374 20606 64297 14366 12778 15550 13609 18169 17203 30044 13488 78134 15559 353344 14765 12772 108071 76854 57254 12062 226278 19217 21390 207911 108072 11548 21337 18166 58182 19219 15552 15466 17199 18241 14362 14527 GPCRs odorant%WikiPathways_20260910%WP1397%Mus musculus GPCRs odorant 258927 381413 233221 233919 83770 18389 14747 238725 259005 12209 259013 229323 493809 240888 80706 67549 14608 404239 14762 258697 258734 387345 68151 218066 18312 353166 319197 229357 338346 212541 258725 78249 215855 383563 215798 237716 54672 18328 224792 18307 387342 107173 18316 52710 227326 58245 14160 209513 14763 258585 404242 76206 14788 18322 110326 258478 406186 243979 233230 113850 381628 258769 215854 12057 22296 113845 258770 80910 18315 113848 27216 113846 209512 276742 78308 171469 241263 387354 258565 64095 64378 236798 259017 436440 24100 233231 241070 100129 381974 73010 258319 70693 78560 321019 277463 113851 258318 259012 258728 353346 503558 238252 70771 257898 112408 22297 229714 77596 245424 113847 387346 113856 329252 71862 83771 353148 269053 233670 269604 228228 404240 258573 387514 80978 387340 57272 113853 258362 319200 14748 435529 353165 81006 387348 235854 387512 387343 23890 83924 258327 258939 14761 18373 235256 113849 258566 70713 14539 14764 56861 84111 14760 80290 387511 258498 387351 56544 382045 11536 64450 68526 244238 257890 258869 404238 243270 258742 258310 381886 243277 211577 258581 217302 239853 239845 217143 258923 387341 258738 209776 387513 387339 107515 14738 18310 239530 387352 GPCRs orphan%WikiPathways_20260910%WP1398%Mus musculus GPCRs orphan 277463 78308 67549 107173 236798 319197 76206 68151 70713 58245 68526 52710 240888 83924 435529 224792 436440 217143 24100 Oxidative damage response%WikiPathways_20260910%WP1496%Mus musculus Oxidative damage response 18538 12262 12577 12260 12273 21938 15139 22031 12043 12902 12015 11783 338372 26415 12540 22030 12268 12575 13067 50908 50909 56196 13063 51789 12267 26398 67384 12263 12576 22029 18037 18033 21926 13197 26401 26414 22034 12259 12367 12018 12371 Dopaminergic neurogenesis%WikiPathways_20260910%WP1498%Mus musculus Dopaminergic neurogenesis 18012 18424 12577 13799 16917 22408 14633 11924 17701 13195 20848 11668 320092 13162 13798 18088 18227 21823 17172 19713 18742 214084 14179 18096 14472 15376 110648 14632 20423 20674 21803 IL 5 signaling pathway%WikiPathways_20260910%WP151%Mus musculus IL 5 signaling pathway 11909 20851 12028 16414 56637 16409 12929 56484 18708 15162 23921 18709 12983 216148 12576 19229 12445 16185 16192 20963 11689 18033 20416 18751 20677 13430 26396 16451 26413 14784 18035 15894 18783 12703 16476 20850 22248 16653 22631 18753 13712 12983 15461 16191 12402 30955 26417 20848 20111 107746 16452 12387 11651 15163 110157 19247 606496 11690 12229 110351 26416 15170 20846 22324 26420 18712 53378 17096 19353 Regulation of cardiac hypertrophy by miR 208%WikiPathways_20260910%WP1526%Mus musculus Regulation of cardiac hypertrophy by miR 208 14463 140781 74318 327987 14613 17700 MicroRNAs in cardiomyocyte hypertrophy%WikiPathways_20260910%WP1560%Mus musculus MicroRNAs in cardiomyocyte hypertrophy 22416 20848 26417 16878 16973 213435 54720 18751 19353 208727 79221 18607 16000 26419 26413 12675 12572 12387 16151 11606 13542 73181 56637 23939 18706 13019 26396 18708 18709 26398 18033 16001 53859 56233 12700 19877 107951 19091 18707 18796 56489 26416 14183 107589 110157 13614 16150 16195 57265 16974 26400 74769 18710 211323 13645 17876 19056 11652 21803 56717 14173 26397 225724 23938 230899 18780 30955 21926 19878 26395 18158 15184 11848 22418 14463 224045 11651 19055 108058 66513 26399 14362 12313 Glycolysis and gluconeogenesis%WikiPathways_20260910%WP157%Mus musculus Glycolysis and gluconeogenesis 235339 13808 20528 21991 20526 13806 56485 106557 18655 14751 103988 13382 18598 14719 14120 20527 13807 14377 56012 18563 18534 16832 212032 16833 68263 27402 14433 18746 55951 18642 14447 18597 18770 11674 18663 17448 56421 20525 14718 15275 11676 230163 18648 15277 14121 18641 17449 16828 70456 Iron homeostasis%WikiPathways_20260910%WP1596%Mus musculus Iron homeostasis 22041 14319 50765 14325 66438 64602 84506 21926 16193 69585 15216 16194 53945 16175 Cytoplasmic ribosomal proteins%WikiPathways_20260910%WP163%Mus musculus Cytoplasmic ribosomal proteins 20084 27367 20005 19896 11837 56040 22121 26451 19989 19988 27176 110954 270106 19921 19933 19934 19943 19944 19951 57808 54217 27050 16898 20103 20055 20091 20042 27370 26961 19941 19946 19981 67945 19982 20102 20104 20115 20116 100040298 27207 20054 54127 20090 14109 67186 269261 66480 319195 67025 19899 76808 108168140 268449 68193 19942 114641 68436 619547 66489 100502825 67281 67671 67891 67248 67097 68052 20044 16785 267019 20068 20088 20085 67427 66481 66475 75617 57294 78294 20111 20112 110651 58988 Glutathione metabolism%WikiPathways_20260910%WP164%Mus musculus Glutathione metabolism 23887 14598 14775 14782 16790 110175 14857 68312 14776 14854 14629 15926 14598 14630 14778 14872 75475 14871 625249 14381 14863 13479 68044 Apoptosis modulation by HSP70%WikiPathways_20260910%WP166%Mus musculus Apoptosis modulation by HSP70 21937 12371 12370 12366 14082 26401 19766 14102 12367 18033 193740 12368 11783 26414 12122 12369 26926 Acetylcholine synthesis%WikiPathways_20260910%WP175%Mus musculus Acetylcholine synthesis 13026 18598 11423 18597 18618 12660 12647 Mechanisms associated with pluripotency%WikiPathways_20260910%WP1763%Mus musculus Mechanisms associated with pluripotency 13990 12914 19696 13016 21752 12578 17246 12575 20841 11819 13865 20683 213742 17480 14175 81879 18109 12168 17128 18128 20130 22418 17344 19164 22018 13380 12622 18033 13590 19280 50764 13445 17191 17192 75560 108155 22196 59024 15182 21849 22632 56380 19821 26424 21414 104383 65969 22592 13197 328572 51869 226442 66830 11614 22764 17865 16600 13211 19712 59016 15161 18999 26417 21432 21386 15901 14465 18986 18451 14388 16451 216233 16195 16880 16878 11789 12005 16842 22773 94093 56717 11651 17869 12591 12443 20848 99377 15221 71950 20674 13194 22059 353283 19211 18707 26395 110157 15461 17126 21812 18119 51810 14182 12159 11477 17125 12550 12387 21415 16412 56637 13542 208727 269424 14362 16973 22416 19247 14784 22702 328572 22286 26380 13619 22772 104156 21420 18424 69890 56353 628746 21888 19664 58198 14281 54624 209446 81601 20662 16324 21803 17131 14030 20588 11545 13018 22097 17342 76804 104263 22715 16647 12367 65079 12505 26413 18103 21425 110147 54427 16367 16337 16333 20423 319757 77683 102060 17977 13017 18747 13435 13436 21418 20230 212712 77766 20750 59004 66894 12912 18140 26611 74178 14176 13164 231413 14797 18712 223775 18260 11909 15894 12189 22218 52463 20997 21331 14472 13864 22025 22668 252870 104248 23988 19877 19878 18752 103551 16009 57278 76509 64058 13139 15260 63913 15162 269275 93762 20833 20689 107932 15078 22589 93960 51792 18291 14566 11479 17765 19646 245688 52615 16468 18158 18160 69719 13347 14056 17127 14055 13626 233726 16211 57258 226432 20687 21750 15111 12934 20591 216850 381022 22289 17260 17261 17927 75788 20393 83814 15251 73693 16598 15201 13433 22083 235497 214498 66317 74766 19651 12566 19698 76893 17975 17089 21848 22160 332221 67155 18854 99982 234366 19697 20586 229542 66923 433759 116870 20466 12224 23942 76007 21886 One carbon metabolism and related pathways%WikiPathways_20260910%WP1770%Mus musculus One carbon metabolism and related pathways 214253 14780 20655 246277 212862 13361 13026 232087 14782 236899 75320 99712 20657 11720 67305 107869 14854 218865 13435 64918 17769 13429 18805 20656 75512 12651 14415 12583 14417 14711 12116 20425 68671 192166 625249 14776 14775 238505 14630 14778 229709 12411 74129 12012 108037 12660 22171 14629 18618 12035 14629 12036 14630 268782 14854 Kennedy pathway%WikiPathways_20260910%WP1771%Mus musculus Kennedy pathway 320951 99712 18618 12651 20397 19210 12660 236899 68671 75320 13026 214253 212862 27388 Heme biosynthesis%WikiPathways_20260910%WP18%Mus musculus Heme biosynthesis 11656 14151 19044 12892 15288 11655 17025 22276 22275 GPCRs class A rhodopsin like%WikiPathways_20260910%WP189%Mus musculus GPCRs class A rhodopsin like 258416 258501 20606 54140 12062 258605 11554 93690 258604 17200 258740 18169 257912 26361 258883 258173 23796 14608 74191 11540 57251 15550 13491 56858 258433 20609 13490 258589 259034 18217 20607 14309 64095 12772 212541 17199 15465 259036 56014 15562 21390 14427 258607 14429 19219 258333 18389 12209 14747 258475 14763 30044 194433 12425 11608 56015 18313 258776 12766 258597 76854 12672 13603 14765 257902 20605 15551 11551 12000 12801 12768 15466 11552 14761 14748 14428 18216 12061 19216 258046 11556 257959 11609 13618 14762 12802 17171 29845 258499 19204 80706 233571 258498 19214 170732 14291 11607 258500 15564 22045 12145 12669 15563 12765 17773 18442 18168 16867 81006 69296 11542 258242 15557 258594 14062 258310 12267 11553 11550 258497 14064 243764 20608 16995 258868 11549 54393 258430 258882 11548 17203 258811 14760 21462 258328 23890 14065 15565 12769 19220 15566 258434 18429 14294 12057 12771 84111 18441 12770 15559 14738 406176 140795 320463 18312 258603 19217 12773 66786 259037 258794 258269 84112 258826 18390 258415 18430 14293 18386 14290 18348 12776 258802 13051 56861 19218 14744 12426 54199 57811 58861 29849 19222 258323 259035 18387 15552 18101 69412 14767 15560 14063 19065 171469 18343 11541 18316 80885 59289 70839 11998 14539 258742 11555 18166 20132 18317 14764 18314 18167 233670 258276 258431 17202 57385 29846 12671 12273 14289 15558 12767 12774 12458 14829 258350 22095 17201 12778 Cell cycle%WikiPathways_20260910%WP190%Mus musculus Cell cycle 12545 12532 22390 12550 208727 21803 12531 17216 268930 12567 12575 12442 12649 12445 15185 12566 50496 71890 30939 19650 27214 242705 433759 18392 56150 104394 17219 15183 19650 19645 19090 66671 56452 140557 12427 18538 17127 12576 56233 12571 27401 50793 17218 12530 209091 50883 17246 12444 328572 11350 17120 105988 12428 56637 21781 12534 17217 218294 12235 12447 15182 12236 54610 12237 12544 22628 13557 15184 12448 26428 18393 13197 17215 12578 22059 13555 268697 11920 17128 18817 229776 13559 17220 17476 107995 26429 23834 245000 Hepatocyte growth factor receptor signaling%WikiPathways_20260910%WP193%Mus musculus Hepatocyte growth factor receptor signaling 107746 110157 215449 20779 14083 12928 19229 19303 14388 19211 15234 26396 218397 26411 17295 26395 109700 13712 109905 26413 18479 26419 18706 12929 20848 15461 20662 16476 14784 16412 330662 19247 26417 14281 Splicing factor NOVA regulated synaptic proteins%WikiPathways_20260910%WP1983%Mus musculus Splicing factor NOVA regulated synaptic proteins 12390 13822 225724 12558 66354 65945 16522 76707 16531 12361 26562 14406 26420 67972 18798 110351 13852 12325 54725 18007 12361 268566 13131 11804 16536 20911 269587 13823 12661 80883 57321 13640 14812 14810 11735 14806 18762 242425 13821 94332 17758 11603 12994 Complement activation classical pathway%WikiPathways_20260910%WP200%Mus musculus Complement activation classical pathway 50908 12260 50909 12259 12262 230558 17174 12263 12266 12279 110382 12274 12268 13136 625018 109828 15139 Ptf1a related regulatory pathway%WikiPathways_20260910%WP201%Mus musculus Ptf1a related regulatory pathway 18609 19664 18096 12387 15205 19130 18128 14165 18519 19668 19213 18609 Hypertrophy model%WikiPathways_20260910%WP202%Mus musculus Hypertrophy model 22388 13685 16177 18124 16175 15978 13684 22339 11910 21417 16478 17700 11487 16007 107765 56405 15200 15982 17928 16173 Heart development%WikiPathways_20260910%WP2067%Mus musculus Heart development 15214 22341 26413 17125 14179 14106 14463 12387 18091 13867 50916 19247 21388 18128 12168 57246 20893 17260 12180 12156 17300 12154 387163 14234 15213 387136 73181 16392 387161 18018 21385 22339 12166 20423 22340 14165 14465 20807 17128 15111 18019 109575 15376 12159 18741 18021 15110 Nucleotide GPCRs%WikiPathways_20260910%WP207%Mus musculus Nucleotide GPCRs 67168 11540 69296 11542 16995 11539 233571 57385 18442 18441 78134 11541 Neural crest differentiation%WikiPathways_20260910%WP2074%Mus musculus Neural crest differentiation 12162 11852 17863 16412 22408 21418 22771 18505 18509 13395 17703 17702 15221 20613 20583 22416 14365 56637 12387 21415 21413 14472 12006 12005 13544 13543 13542 12159 17125 15901 18128 13389 18132 18129 54485 18131 13388 15214 22160 20665 14173 15208 15205 19664 14182 14183 14184 65100 107771 20682 16392 12563 12558 12550 20678 23871 18033 241201 18034 18014 18935 14580 50914 50913 14618 17172 17342 18858 17528 17196 16869 16870 14179 14170 433759 15182 15183 208727 15184 15185 56233 70315 79221 170787 232232 13017 13190 12824 12815 12587 20890 15407 235472 94222 21389 15394 16873 21909 21419 140477 15110 Alzheimer 39 s disease%WikiPathways_20260910%WP2075%Mus musculus Alzheimer 39 s disease 234664 11820 11785 11487 23821 66340 19164 59287 226548 15925 17380 16956 11816 16971 14102 21937 14082 12370 15108 12122 12314 56398 12015 70405 80796 19055 19056 19057 19058 19059 70261 11491 19165 11783 12371 12367 20617 14810 12288 14811 14812 14813 14814 12289 54652 12292 14682 18795 18796 18797 18798 21926 16176 26413 26417 12364 20192 11938 11937 53313 13666 78943 226641 16438 16439 16440 12333 12334 22059 12569 18125 12568 17762 56637 12369 Serotonin receptor 2 and STAT3 signaling%WikiPathways_20260910%WP2079%Mus musculus Serotonin receptor 2 and STAT3 signaling 15558 16452 14682 20848 SREBF and miR33 in cholesterol and lipid homeostasis%WikiPathways_20260910%WP2084%Mus musculus SREBF and miR33 in cholesterol and lipid homeostasis 20787 19017 50721 15357 93759 56717 22259 19013 723897 94112 20788 16835 Serotonin and anxiety related events%WikiPathways_20260910%WP2140%Mus musculus Serotonin and anxiety related events 15558 11838 15560 15550 14281 56193 19055 18751 18802 14814 192167 12921 12918 Serotonin and anxiety%WikiPathways_20260910%WP2141%Mus musculus Serotonin and anxiety 18802 56193 18976 14816 193034 18751 12323 14265 12918 19055 13629 14394 11838 15560 14281 15550 11549 11838 13629 15558 BDNF pathway%WikiPathways_20260910%WP2152%Mus musculus BDNF pathway 18791 12064 18212 12043 327826 22059 18815 225724 12912 19353 12028 20416 12540 18053 18787 12064 18815 Striated muscle contraction%WikiPathways_20260910%WP216%Mus musculus Striated muscle contraction 21925 21956 12373 13346 21955 17897 21924 22138 13405 22003 21952 17996 21953 11465 17868 17879 22352 17883 11464 22004 11474 233199 17884 17906 326618 11472 109272 21916 17896 17885 17929 17888 98932 66106 21957 21954 11475 17901 17930 140781 59069 21393 11459 60595 71912 Purine metabolism%WikiPathways_20260910%WP2185%Mus musculus Purine metabolism 102216272 108143 18605 75686 209558 633979 73532 73532 18605 68870 215446 18770 18573 14198 242202 20020 56520 69833 667034 18577 50773 16434 20021 110385 171567 667034 210044 23984 18950 18576 14450 23959 225600 18102 18102 230718 27369 75533 76952 18968 70881 171567 18746 18573 18968 66355 67486 18577 218461 72090 76952 18969 15452 230718 230103 11636 215446 18574 11637 382985 67967 67710 103850 18950 70881 54611 15452 26939 12496 76974 72090 69745 16434 11512 18746 66358 238871 107569 20016 20020 18969 229665 78929 64424 18583 18974 18574 66401 215446 19139 71701 18950 11514 20016 667034 54369 229949 667034 230718 70881 231329 18973 241489 107569 108147 69241 16434 18584 14544 11566 18588 171567 105446 239134 54369 218461 66136 18103 54195 56520 18583 229589 667034 234889 18575 245650 20133 11821 20018 66401 67464 56520 94041 18103 72090 18584 103850 20135 70408 67054 11486 23959 18973 74414 11821 66491 66979 11514 54611 14450 230718 18972 19075 76952 12495 69745 382985 224129 18971 18950 20022 18582 79059 229363 23972 79059 207728 78801 54369 78801 76952 23972 14919 72090 11565 18102 11515 11821 67967 20135 15452 14450 20017 215446 11564 22262 14923 103850 11636 20022 18770 20018 60596 67486 69241 11486 23959 18103 14918 16434 432530 59001 18770 74414 11639 103850 54369 23971 23918 19075 13178 66979 18578 12497 20133 110385 12495 215446 12495 20019 75533 23918 66420 238871 56520 210044 79059 271639 75456 14917 59001 53893 78929 50773 231903 110639 66491 50773 20017 69920 18102 667034 76952 103850 67005 229949 76025 69870 76952 23959 12497 79059 70428 75533 19076 75533 12495 18974 29863 11534 224129 72157 18746 69870 67464 107569 18746 69833 218832 18160 11639 18950 66681 18585 76025 11515 70881 107569 50773 50773 12499 20021 104110 18950 72090 230718 18578 70881 12495 72090 18575 64424 11513 230718 22436 207728 16434 66136 245841 20019 19076 50773 11717 12495 104111 107569 11564 23917 18972 23959 103850 67005 110855 18770 23984 67054 328099 26939 215446 70408 171567 18576 11637 218832 70428 432530 231327 245841 104110 12499 23959 18971 109674 66420 66401 104111 14923 71701 67065 70881 69920 78600 107569 231329 11513 67710 271639 18587 29863 67065 23971 11512 108147 241489 74167 237823 18103 100862375 68695 Cytokines and inflammatory response%WikiPathways_20260910%WP222%Mus musculus Cytokines and inflammatory response 16175 16176 21803 16153 12504 16187 15962 16189 16163 12977 16196 15978 16183 12985 21926 16168 16191 14825 330122 16193 16160 16156 12981 16159 18590 15977 14969 Macrophage markers%WikiPathways_20260910%WP2271%Mus musculus Macrophage markers 12522 12475 12514 14066 93671 12524 16149 23833 19354 17105 Chemokine signaling pathway%WikiPathways_20260910%WP2292%Mus musculus Chemokine signaling pathway 13051 216869 66102 14710 20301 100039863 100040048 12929 14706 20299 18708 22325 56484 18747 210044 20295 56637 57349 12928 14700 18751 14678 19354 19353 16452 12540 110157 277360 20303 14697 18709 14707 12776 20306 18033 12675 14083 12988 21844 14695 18710 18798 94176 109880 12770 20308 20312 17096 18749 224129 12771 23832 19303 20416 12777 66066 56744 16453 18479 73178 20311 12927 14702 19395 20846 20418 74769 20290 18707 12775 606496 12768 110355 22324 20847 20292 26385 18797 17329 216148 320207 80901 57266 20307 20293 14679 20851 12773 271849 14708 12767 14688 26413 18762 16428 14784 18706 19877 19108 19878 19697 20662 12766 14701 100503710 14709 11513 109905 16653 16963 20663 18796 11652 12774 12772 20315 14825 17969 14699 15945 56221 14772 12458 20302 23797 12769 18795 16150 20305 15461 56838 93742 24001 20296 11651 227288 20309 57257 18176 14191 19229 14696 22376 24047 18762 20300 26417 104111 24013 104110 11514 20301 100039863 100040048 64337 11848 140580 15162 55985 14677 18035 20848 12145 541307 11515 26395 18753 14693 20304 18036 14773 215449 109689 18829 20310 16151 432530 20297 14704 12765 11512 30955 PPAR signaling pathway%WikiPathways_20260910%WP2316%Mus musculus PPAR signaling pathway 235674 19015 69050 19016 22190 74551 666168 13124 22227 26457 15360 13117 20182 11832 20250 11430 13118 30049 329065 22259 20181 328845 14080 13119 20183 20182 216739 57875 104086 74205 12140 11364 12895 78070 20181 277753 14077 100040843 14079 50790 13167 26458 26569 11807 12491 26457 14080 17436 11450 11814 433256 11770 19013 56473 20183 13122 18830 14933 103968 26459 80911 66113 93732 18534 12896 14081 16204 20182 83996 108078 26569 230639 12491 83995 225579 435802 94180 20280 20249 16956 16202 11806 14626 14077 20183 12894 20181 20411 11770 16592 74147 18607 11363 113868 Fatty acid oxidation%WikiPathways_20260910%WP2318%Mus musculus Fatty acid oxidation 15107 93747 11370 11409 52538 15107 93747 17777 11364 12896 12894 214663 G protein signaling pathways%WikiPathways_20260910%WP232%Mus musculus G protein signaling pathways 19088 14700 29863 104111 224129 14701 66066 56399 19057 11640 19085 14683 18753 14695 18577 18574 14682 14681 238871 18751 20130 14675 238276 14687 104110 218461 18176 64337 14699 14693 19084 14672 18755 19055 14677 12313 18749 19087 14697 16519 18797 432442 14674 11512 11642 18573 18575 210044 14680 18760 75292 11515 238161 432530 75547 14676 18584 83397 11848 11643 14679 219181 14710 18761 110385 14709 18754 14708 18752 14688 18750 18759 14707 14704 15461 18762 16801 56697 11514 11513 18747 18578 16653 18583 100986 14706 14673 16438 20544 14678 GPCRs peptide%WikiPathways_20260910%WP234%Mus musculus GPCRs peptide 12426 22095 21336 12776 12770 18166 26361 12061 20609 12000 17200 19065 12267 14309 18167 16867 18430 12773 12766 12145 12769 13618 12768 18386 17202 14429 18169 20605 17199 12273 11609 18390 20606 18387 21337 14428 22045 18217 80901 18101 69412 20608 14829 54140 12765 13051 17203 208188 17201 13617 12062 12767 14294 12774 12777 18389 12771 14427 12458 11608 11607 18168 12425 18216 12775 12209 14293 12772 21338 14715 20607 miRNAs and TFs in iPS Cell Generation%WikiPathways_20260910%WP2375%Mus musculus miRNAs and TFs in iPS Cell Generation 68479 70052 53607 53817 18999 20674 75062 Osteoblast signaling%WikiPathways_20260910%WP238%Mus musculus Osteoblast signaling 19226 18383 18595 21943 19228 64654 12842 218103 12097 18596 Alanine and aspartate metabolism%WikiPathways_20260910%WP240%Mus musculus Alanine and aspartate metabolism 14415 268860 226414 11484 109900 76282 18563 11898 14718 11611 14417 14719 11564 12908 107239 Spinal cord injury%WikiPathways_20260910%WP2432%Mus musculus Spinal cord injury 18053 69583 16995 24099 19283 18610 16994 18845 121021 16423 22695 14130 381833 19262 16176 18126 21926 15370 16189 12227 12566 18125 16183 16193 21898 14281 21803 13653 17381 15978 17196 68585 15139 14825 11829 11846 13838 13642 15945 12450 17395 13004 20562 20563 20564 18208 244058 12772 16177 16175 20310 20296 53357 18784 18780 16952 15894 20344 259277 14580 12567 21336 13559 19645 18750 13555 26413 12443 17869 13197 26417 12367 22059 58250 13003 12826 233781 12824 11595 12032 20682 14810 22352 19055 14432 14225 17136 11848 11853 11852 19878 18377 65079 18733 50490 387217 12534 14573 20358 14609 12064 TNF alpha NF kB signaling pathway%WikiPathways_20260910%WP246%Mus musculus TNF alpha NF kB signaling pathway 23881 69721 14113 18036 15516 72508 230233 544963 57751 12366 56489 16709 328949 19698 16648 16151 12389 20340 26401 19179 19182 12335 26410 17846 11651 13001 22627 20016 103583 18567 15519 56637 21926 26965 56456 19766 19697 71833 66997 211550 21938 22032 12905 19052 12995 22030 16650 80859 67891 18035 22196 26572 74256 22682 245841 11797 22629 109658 22034 68652 70247 56532 17463 22031 21941 446099 14082 12234 18033 21937 17218 23938 71966 192176 18616 15182 64424 21353 22631 53859 14886 14229 68052 19946 22033 219158 12367 22628 333654 56480 57783 26961 67384 18034 73086 20587 14694 18037 26405 231130 76784 19696 12675 68094 11652 26885 21934 20018 21929 54401 14084 57376 18854 12633 192656 27215 12370 11796 22036 53376 21402 16150 12539 19708 15507 66724 22029 192170 20586 76589 14388 433759 23997 23980 211651 229615 16535 26406 18747 12914 19181 70333 20779 15185 18762 216150 17220 320795 108086 20588 22218 18201 27207 14083 11647 71609 20019 12051 22026 77045 13000 22123 66413 12369 226525 20017 236733 13728 56399 18789 20846 16647 13205 19988 18637 223453 72416 19247 56407 19173 66513 Mapk cascade%WikiPathways_20260910%WP251%Mus musculus Mapk cascade 26416 16476 18176 110157 26406 26401 26417 13712 17756 26398 15461 26404 26414 26396 17196 29857 26399 20469 26413 19414 20130 11836 16653 26405 109880 26395 26397 18797 Androgen receptor signaling pathway%WikiPathways_20260910%WP252%Mus musculus Androgen receptor signaling pathway 12534 433759 11835 20779 27057 14815 15469 19645 104156 59004 13982 12017 97165 110157 20602 16476 12317 56218 217127 20848 11651 56736 12447 30051 19822 56424 12393 16195 223870 18987 23957 22196 11909 16000 17128 18193 12859 12387 14797 68098 16193 14884 12389 67655 56705 22294 66671 19211 72993 14200 98053 22215 108767 19697 13649 14600 17344 22059 268903 214230 12572 328572 11739 192176 81000 15259 26395 12362 22634 17978 12189 13983 22026 21815 229615 12531 83995 12370 21674 12367 12369 193740 18813 26423 225115 11614 12914 12443 17977 17246 22629 19384 19303 56469 21804 17979 17127 170758 20683 81601 18986 26413 68705 107951 20466 19183 232286 12394 12539 Primary focal segmental glomerulosclerosis FSGS %WikiPathways_20260910%WP2573%Mus musculus Primary focal segmental glomerulosclerosis FSGS 16410 21898 12323 11651 13429 67703 16416 22330 16449 243911 17973 12476 13039 19277 16776 13380 14360 18793 14083 54139 22370 22630 104027 21803 11603 12488 16691 170484 16779 54631 18803 12576 12946 18504 27205 16917 71602 12492 14107 192897 12830 12577 17380 22352 12575 74055 60595 17886 54380 22431 70435 22068 18538 17345 12558 12737 12828 12829 110829 12519 18128 12387 16974 16973 21894 16202 16412 16400 13138 57342 22288 TGF beta receptor signaling pathway%WikiPathways_20260910%WP258%Mus musculus TGF beta receptor signaling pathway 12234 21813 13018 13559 11910 18519 16477 17260 216080 108058 21417 19877 16476 19651 18046 54601 24136 71770 13805 17127 21814 21402 218210 217232 12567 104394 12393 12387 19645 12575 21812 19087 66354 26416 15228 52206 18045 14106 17131 216869 66313 69957 56438 75901 17126 16842 26399 21781 21803 68999 22062 22601 17869 12443 26965 22337 20683 59008 230597 69150 20482 56317 12389 21809 103573 14225 18708 14272 17128 75788 12505 18709 99152 26754 386655 12534 17344 13163 11909 23871 21815 12914 71728 14281 76793 21808 11835 72183 20869 14282 227720 18753 26419 19650 13542 56371 15405 16478 18751 17130 66513 52563 20481 26397 328572 66105 211586 12005 20901 15481 76630 93742 16211 13132 22218 15239 12442 13982 17258 12530 56550 54709 12006 19085 15529 12571 17222 56469 67804 12447 26409 56484 11482 56440 18044 17977 67903 68015 56458 59079 12566 71978 433759 12323 12322 12325 22059 15378 20692 12705 Delta Notch signaling pathway%WikiPathways_20260910%WP265%Mus musculus Delta Notch signaling pathway 18128 18129 18131 18132 13388 54485 16449 16450 19164 19165 208117 66340 59287 11487 11491 56637 18222 16396 11820 18223 18708 18709 11651 18550 12805 18133 14357 17172 328572 22059 16848 17305 140484 21402 50754 15213 270118 433586 103806 66354 20602 20185 433759 66935 60406 15182 20466 15205 20848 16452 19697 18035 15214 21885 17127 17128 22632 12566 16842 17260 26965 27401 21423 26417 26413 57750 14199 19763 16656 56381 17125 55927 22761 17137 12804 12803 15208 16818 16476 19664 13645 13649 Ovarian infertility%WikiPathways_20260910%WP273%Mus musculus Ovarian infertility 12167 19116 14309 16867 22788 13404 11920 17350 17687 14566 22787 20597 13164 14612 16322 17127 18667 13983 22337 26423 21374 20185 268903 13653 12608 19217 12576 12444 12567 13075 319565 B cell receptor signaling pathway%WikiPathways_20260910%WP274%Mus musculus B cell receptor signaling pathway 13712 15184 18021 14784 12444 26413 19058 11909 77799 18719 76709 12483 14389 19697 12042 218397 22324 107746 18604 72508 83490 13448 18718 18760 14388 68089 56743 18019 56233 20846 19264 12371 16439 12572 12571 15162 30955 16822 110157 14360 11867 26377 18803 17164 19645 66713 20848 12369 12518 22637 12912 208650 15163 26395 19247 16151 20111 117150 18709 68119 76108 18753 12053 16331 20963 12478 16150 12387 109880 14083 242248 12229 19696 56458 27261 77590 12902 12927 12929 17096 108723 12567 16438 18751 83436 26411 18720 11651 20663 12445 23921 18003 381290 56792 108083 12675 12125 26396 24055 12517 12928 18035 26419 240168 18754 67603 20662 15170 12988 12143 16818 12566 14886 11848 12028 225724 16476 18018 22325 18708 21682 319520 14130 74117 19229 234779 18761 12520 101476 17973 606496 16428 18607 22376 56637 15387 12402 26409 19253 12507 20104 12043 20416 72699 26417 12428 56378 15985 19055 67771 17060 26416 12447 19056 18717 Focal adhesion PI3K Akt mTOR signaling pathway%WikiPathways_20260910%WP2841%Mus musculus Focal adhesion PI3K Akt mTOR signaling pathway 12826 22084 53867 21828 19116 20662 12831 16420 105083 16453 16186 319480 12815 16780 14784 329278 20869 14599 16188 13857 16404 16409 12843 216505 15891 12832 18414 94216 21827 16398 16773 12824 12829 12985 192897 16402 16775 320910 381924 16416 16776 14083 12643 213119 81877 16400 12842 16403 13856 16410 16772 22371 12825 23797 16411 16414 16190 16399 12986 15976 23928 16197 21826 16421 15965 20750 14268 74747 12814 16401 16452 16451 22370 15962 15964 11651 74769 18707 14600 16194 12845 226519 16779 16185 18706 16774 16184 19211 16777 19699 75669 12827 64930 16412 241226 16407 104099 12834 16419 21825 16408 11652 18708 18709 16782 21923 15975 21960 320207 13636 14164 14166 14165 13637 13645 14167 12977 11602 11601 11600 22339 13638 13639 13640 14169 14168 14170 14171 14172 14173 14174 14175 14177 14178 14179 14180 14205 15234 16000 16333 16334 17311 22341 22340 18591 18654 18590 18049 54635 56636 67112 71785 80857 80903 14183 16542 16337 14184 16001 16590 14182 13836 13649 12978 14186 14254 14257 18053 17295 18595 18596 21687 67605 15967 15968 15969 15970 15972 15974 15977 16183 18413 19109 230396 404549 12669 14745 14062 243764 381810 53978 65086 67168 78134 14693 14688 100503710 14696 14699 14700 14701 14695 14702 14704 14706 14707 14708 14709 14710 64337 66066 30955 18176 16653 15461 72149 12283 69008 105787 108079 56716 19744 56717 74370 15251 22241 74343 12539 15516 98432 21432 18607 100039815 19053 19052 100039830 21770 225849 72930 73699 19054 235542 26931 26932 269643 51792 52432 226849 59032 15519 22027 244650 17763 27379 27380 110157 26396 26395 26413 26417 56637 56484 56458 16150 12015 12371 17246 16151 12576 12575 11909 12913 12912 11911 208647 208677 12915 26427 78284 231991 18127 57915 17274 59021 19325 19326 68365 20528 20525 20527 20526 19017 14936 232493 18640 18639 170768 270198 16890 20787 15375 107476 15568 18125 18126 13819 53417 58988 13685 75705 72508 20104 13684 26987 218268 240752 18704 18705 16367 16370 16369 384783 Gene regulatory network modelling somitogenesis %WikiPathways_20260910%WP2852%Mus musculus Gene regulatory network modelling somitogenesis 14179 21389 382089 17293 13838 84653 15205 16848 18128 13388 22416 White fat cell differentiation%WikiPathways_20260910%WP2872%Mus musculus White fat cell differentiation 22410 13591 20787 12606 12608 14013 19883 13198 12912 54131 20851 66277 12224 14461 21415 94187 13654 14462 11819 19016 22259 12609 12385 16600 19401 56458 20850 21887 16333 14815 16364 16598 Notch signaling pathway%WikiPathways_20260910%WP29%Mus musculus Notch signaling pathway 19664 16449 433586 14357 15182 13544 11491 13017 18131 103806 13543 13542 66935 59287 226548 19668 18128 20602 18222 209200 13388 66354 19165 54485 18129 18132 12914 80904 74198 15205 18519 207521 16848 433759 16450 19164 13016 13389 17305 18223 21926 19719 19208 208117 14534 15208 p53 signaling%WikiPathways_20260910%WP2902%Mus musculus p53 signaling 11920 50883 245000 12649 12578 17246 17248 22059 12575 12443 12444 12445 12567 12571 12447 12448 12566 55948 67874 268697 12442 209091 434175 12534 13197 17873 23882 29870 14102 57913 12370 12122 12028 58801 170770 13663 66940 64058 22401 20437 20438 13063 13067 11783 12371 12367 16009 16000 18787 107831 12521 21825 20724 107986 382985 20135 140742 230784 75747 19211 22084 68428 26374 68098 12450 12452 53892 22062 miR302 367 promoting cardiomyocyte proliferation%WikiPathways_20260910%WP2904%Mus musculus miR302 367 promoting cardiomyocyte proliferation 15235 50523 68473 22601 Mecp2 and associated Rett syndrome%WikiPathways_20260910%WP2910%Mus musculus Mecp2 and associated Rett syndrome 20185 17932 18996 11813 14175 12064 18015 20604 27528 53618 17257 18992 22608 14174 13006 14810 17260 21354 268859 12799 14056 14431 18387 622434 20466 20683 14415 270627 59013 13007 13395 57810 17932 12609 17196 12053 14409 13018 20687 70767 13555 19712 17136 14173 26913 52463 98758 22608 12912 miR 222 in exercise induced cardiac growth%WikiPathways_20260910%WP2928%Mus musculus miR 222 in exercise induced cardiac growth 12576 219150 15258 15257 Electron transport chain%WikiPathways_20260910%WP295%Mus musculus Electron transport chain 11946 230075 11958 11740 226139 110323 66152 12864 57423 28080 67942 66377 11947 68375 66594 66091 20523 72900 67130 17709 66218 407785 66694 17991 17720 17706 595136 12858 67003 11957 67680 17708 20463 75406 12861 74011 17993 12865 12857 27425 22229 66576 66108 66495 100041273 68194 100042503 12866 17722 68055 66945 17717 70316 66142 22272 11739 67530 17721 66414 52892 66925 11983 66916 54405 22273 66046 12859 17705 17710 68349 12868 17716 17995 66052 228033 12862 20930 227197 66416 17719 71679 68197 68198 226646 66043 68342 12856 17992 68202 11950 67126 11949 78330 67273 22228 17718 225887 17711 22227 IL 7 signaling pathway%WikiPathways_20260910%WP297%Mus musculus IL 7 signaling pathway 12125 12028 16362 20416 20844 12428 17829 14360 17096 20846 17210 20850 11651 16186 12567 208650 15461 12444 20662 16451 56458 26396 19229 26395 384783 16197 12402 18708 110157 12566 12143 12015 20848 26413 16453 16367 26417 19645 56637 14784 20851 67300 56484 56324 G13 signaling pathway%WikiPathways_20260910%WP298%Mus musculus G13 signaling pathway 20166 320795 12632 52428 11848 18643 16801 24068 14674 544963 29875 18707 11857 74769 59009 16885 53311 19353 51789 18481 18718 26414 12313 73178 18709 19046 22376 26407 17901 12704 14570 19877 13367 18706 12540 72508 19878 12631 Histone modifications%WikiPathways_20260910%WP300%Mus musculus Histone modifications 107435 433759 15182 77683 110147 Translation factors%WikiPathways_20260910%WP307%Mus musculus Translation factors 22384 13628 13690 224045 217715 26905 19106 13629 217869 55949 20918 68135 16341 13631 16418 13667 225363 13681 13682 13688 18458 13669 66656 13664 75705 13685 208643 78655 13665 66085 26908 276770 53356 108067 13684 209354 54709 56347 218693 230861 13627 18459 55944 108112 13666 67160 15467 67204 27979 mRNA processing%WikiPathways_20260910%WP310%Mus musculus mRNA processing 20020 74111 18139 68035 110957 22184 66679 237073 19847 20822 101943 207920 15382 67579 66055 24128 15547 20658 29813 234373 13206 66492 56417 20462 66164 109729085 67053 24014 117903916 27366 109075 66405 76167 72160 21744 12877 24018 75420 19848 19941 27041 68219 19653 69597 19826 74326 50926 102462 50911 57320 76938 76572 53610 67671 67456 19989 20624 66704 319695 20641 234733 53607 93728 53356 69207 20638 14030 20595 241490 66446 228410 54127 71713 246730 243272 20005 216578 70616 19106 321006 268859 72567 56031 69724 19845 67248 19357 23879 94191 71514 233908 231769 244631 100336 70233 235402 66585 66475 18789 108014 19657 229279 13205 12021 70052 58203 13164 80912 19134 68379 14007 140486 104307 56381 67842 19934 67949 19844 56190 192170 217337 56195 224344 68879 68278 384281 66185 18458 72935 15568 20630 67337 20853 20637 20639 17184 12748 13046 56009 66983 68598 20826 104721 338351 53890 12828 14962 319322 19862 115489655 66230 68092 13682 13211 27225 319586 56194 67936 108013 19017 72459 218543 52874 68172 20646 71713 70439 110809 107951 229279 77604 67197 83675 115488065 115488060 19842 18938 20090 57317 217207 75710 19844 320158 98985 68165 16201 15387 21843 239188 67418 77411 52521 192159 30959 23962 72735 98685 68479 246277 23983 69639 67434 20817 26961 353258 236732 57294 27275 27993 50783 19656 11428 22384 53379 230257 83410 66892 71766 170826 102857 21357 245945 193116 69192 269261 70044 12696 66599 230721 230603 15572 12189 67120 67025 229663 20821 19383 13690 272009 20975 15388 76626 26919 70930 27979 67710 67920 20823 77134 15469 16865 22034 52202 26987 19951 209224 67427 67465 381626 207181 13684 215615 53817 140488 51796 53975 18521 56758 72662 27756 78784 56215 53319 246727 231413 66094 20044 68272 108121 102414 19663 70767 230908 20088 22185 12750 64340 15571 20383 109095 11640 269061 69207 20826 19654 21752 75062 67667 54614 98758 213236 60365 51810 56316 11992 56258 56516 18459 20222 115488065 115488060 19842 20747 170722 16589 54451 11739 19205 27058 22380 14359 107686 23960 76897 217351 67010 19655 170791 66810 19935 74484 100861987 81898 69408 114896 53621 67959 71684 18542 51786 15569 20102 107701 224902 232089 230861 76846 67229 94230 13722 20384 68195 13680 11499 66419 20815 69878 66645 66660 66384 19921 68052 14265 59093 78304 73826 56335 67039 27998 72290 14208 72397 74213 106583 72054 246728 67390 100121 171190 59013 83410 67897 208606 13209 19652 100043257 75388 24067 24061 15468 56403 67889 80913 70248 21841 19317 13204 68011 76522 67207 71973 76938 19848 108657 380773 18670 68581 20813 100502825 67281 13207 15381 208718 56200 14105 14113 20382 54196 23961 67543 15384 53609 59092 67958 52513 17690 20462 208922 57837 11991 30947 56275 19845 108062 20238 20643 22099 21681 76183 67332 76936 67996 20115 54188 68744 66125 22608 218543 17975 27632 225027 56878 27207 20104 18148 192119 209003 53791 68981 67225 19656 20924 83486 20492 93871 67444 17876 12747 72692 56522 93686 Glycogen metabolism%WikiPathways_20260910%WP317%Mus musculus Glycogen metabolism 19309 19053 102093 232493 225849 68961 26931 12313 18679 269643 110078 216558 14936 606496 235542 27357 51792 12315 26932 19052 21770 72930 77559 226849 12314 110094 71978 56637 18682 73699 74185 72157 110854 110095 Eicosanoid synthesis%WikiPathways_20260910%WP318%Mus musculus Eicosanoid synthesis 11690 19215 96979 13479 19223 18780 11689 21391 19224 14598 53357 11687 11688 64292 16993 19225 17001 67452 11684 GPCRs class C metabotropic glutamate pheromone%WikiPathways_20260910%WP327%Mus musculus GPCRs class C metabotropic glutamate pheromone 14816 108071 108068 108069 14823 268934 108073 108072 12374 54393 242425 93746 70355 64297 232431 Fatty acid omega oxidation%WikiPathways_20260910%WP33%Mus musculus Fatty acid omega oxidation 26876 13106 11529 13077 11668 320092 11669 13076 11522 Fatty acid biosynthesis%WikiPathways_20260910%WP336%Mus musculus Fatty acid biosynthesis 14104 93747 433256 111175 52430 107476 52665 50790 20249 60525 67856 104112 74205 15107 100705 14081 18563 52538 26922 67460 216739 51798 ESC pluripotency pathways%WikiPathways_20260910%WP339%Mus musculus ESC pluripotency pathways 14368 23797 13544 66713 17125 56637 17129 17869 15461 12166 109880 18590 22415 14164 17131 22419 80903 18591 14177 14170 11477 14182 26395 12387 14366 67112 13542 16451 12168 16476 14165 18707 14180 14370 20848 20662 80857 11652 110157 14166 22421 14371 16195 14184 22418 23939 57265 14171 14367 93735 14172 14369 14362 13649 17246 22409 14186 14183 18595 26413 18121 11836 56717 17128 22422 55994 26397 20363 16878 16880 22413 23938 18709 16973 22412 12005 13712 14169 22416 12167 50772 19247 64654 14176 14388 19211 22411 14784 13543 11789 11651 21405 22417 17130 14173 22408 225724 14167 56636 22420 13645 29857 14365 22410 18596 14281 14174 14168 26399 26396 14178 12159 14179 353283 14175 22414 16974 p38 Mapk signaling pathway%WikiPathways_20260910%WP350%Mus musculus p38 Mapk signaling pathway 17164 14784 22030 15507 20416 26399 338372 19353 21812 17261 11909 20846 12912 26408 17346 26409 19766 73086 26416 13712 17187 15461 12540 15312 18783 26398 13198 19417 21808 13163 26401 17869 71609 GPCRs small ligand%WikiPathways_20260910%WP353%Mus musculus GPCRs small ligand 17773 12802 19216 19217 14739 19219 13610 13609 12801 21390 19204 14745 19222 19214 19218 13611 244701 19220 Fatty acid beta oxidation streamlined %WikiPathways_20260910%WP3588%Mus musculus Fatty acid beta oxidation streamlined 14079 97212 12896 11364 231086 15107 14077 13177 11370 433256 225579 11363 14081 57279 216739 12894 14080 12895 12491 12140 50790 11409 67460 110446 11770 93747 74205 26457 26459 26458 26569 26568 ApoE and miR 146 in inflammation and atherosclerosis%WikiPathways_20260910%WP3592%Mus musculus ApoE and miR 146 in inflammation and atherosclerosis 18034 11816 19697 387164 20375 16179 21898 22034 24088 Tyrobp causal network in microglia%WikiPathways_20260910%WP3625%Mus musculus Tyrobp causal network in microglia 27060 99586 67742 16164 14775 16409 668218 76448 80719 66824 105855 20514 338355 67963 66102 22177 15284 12504 239273 20540 245945 54519 12262 16414 216991 217203 12332 20850 56501 20111 20750 208647 12193 12399 56193 224109 17095 16950 12266 17970 238875 12493 21812 330217 12523 16411 78416 15163 16154 16923 231162 21938 50778 16173 57442 108735 17132 218454 Microglia pathogen phagocytosis pathway%WikiPathways_20260910%WP3626%Mus musculus Microglia pathogen phagocytosis pathway 15162 12259 22177 20963 18708 83382 58217 14127 14129 16409 83433 58218 16414 17096 15170 234779 16797 19353 19354 170758 22324 22325 57257 105855 11867 17972 17970 17969 13058 13057 12260 12262 30955 18706 18707 74769 18709 225326 18704 104709 18710 Lung fibrosis%WikiPathways_20260910%WP3632%Mus musculus Lung fibrosis 269400 20310 20750 224897 14164 20303 17131 14219 74108 20296 20482 21926 20387 16193 13614 13717 12985 23892 109620 21752 17257 20309 108689 12310 21802 16163 16176 12771 20304 18590 20292 50770 14173 17228 16191 13645 21857 16160 12162 18591 19288 18024 17395 14178 74180 12608 70086 15368 17390 15234 20389 12772 16189 12981 244548 18792 58909 20302 17750 16000 21803 Parkinson 39 s disease%WikiPathways_20260910%WP3638%Mus musculus Parkinson 39 s disease 107508 13195 13162 22223 50873 20617 21823 66725 68943 57320 64704 13063 14763 18951 67847 22187 22201 74153 22195 56791 140499 67128 22213 56228 20239 229521 12447 12448 29857 19094 26416 26415 12368 12371 12366 13063 12369 12367 11783 Ectodysplasin A signaling in hair follicle development%WikiPathways_20260910%WP3652%Mus musculus Ectodysplasin A signaling in hair follicle development 18033 19698 18034 19698 16994 18033 13608 19697 234130 66042 19697 171211 13380 14632 19206 20423 13607 13607 Novel Jun Dmp1 pathway%WikiPathways_20260910%WP3654%Mus musculus Novel Jun Dmp1 pathway 13406 11840 16653 16477 26413 12578 110157 17869 12567 12443 13555 19645 23871 26395 23872 16476 22059 17246 20130 18176 15461 11836 109880 26396 26417 14281 BMP signaling pathway in eyelid development%WikiPathways_20260910%WP3663%Mus musculus BMP signaling pathway in eyelid development 14165 14183 16324 21802 20423 12159 20377 17125 17129 17128 18741 56811 17300 14234 18128 26401 26420 16476 13649 26417 Hfe effect on hepcidin production%WikiPathways_20260910%WP3673%Mus musculus Hfe effect on hepcidin production 15216 71753 69585 84506 12161 17131 15901 Factors and pathways affecting insulin like growth factor IGF1 Akt signaling%WikiPathways_20260910%WP3675%Mus musculus Factors and pathways affecting insulin like growth factor IGF1 Akt signaling 17127 19017 56458 17126 19079 17700 21950 11651 16412 21937 433766 16367 18805 16202 228026 56717 72508 21926 19211 16001 16000 16011 11481 56717 18033 16006 16009 16010 16008 29817 16012 104771 IL 1 signaling pathway%WikiPathways_20260910%WP37%Mus musculus IL 1 signaling pathway 16180 19261 67245 16179 108960 26413 266632 53859 18035 26395 12675 26409 19697 16176 16175 22034 16177 16181 73914 16175 26417 12333 266632 68652 18803 18762 66513 18033 12336 18036 16178 19247 26419 12362 18412 230233 16176 54473 11651 17874 IL 3 signaling pathway%WikiPathways_20260910%WP373%Mus musculus IL 3 signaling pathway 16187 20846 110157 20850 14128 20525 56461 12402 15170 11909 20416 23939 16452 19303 22631 22330 20852 14388 21682 54721 17179 26413 14083 18707 14461 18708 17096 12015 12125 14784 12983 20662 11908 22324 12649 12928 16451 20848 18750 15901 14694 26419 14389 20851 18747 12169 16818 54401 26417 13429 11799 26416 16188 19052 11651 18033 58988 56637 21938 12043 20375 18751 14460 17532 16653 17395 19247 12912 109905 19401 20963 20779 18706 12028 17164 12700 18709 26420 15507 16331 12929 14159 15461 19354 107746 20344 606496 56458 18479 216233 20181 26395 15162 17390 12702 19353 12048 12540 14360 Prostaglandin synthesis and regulation%WikiPathways_20260910%WP374%Mus musculus Prostaglandin synthesis and regulation 13617 19225 13618 19223 20194 19109 15446 20200 11745 21391 11752 19222 11747 15483 18783 19224 19215 16952 19214 13070 11746 19216 15484 19219 19220 11749 22287 19217 19218 12306 13614 Myometrial relaxation and contraction pathways%WikiPathways_20260910%WP385%Mus musculus Myometrial relaxation and contraction pathways 51801 16012 64337 50782 18762 224129 20190 53313 11911 19088 18752 210044 18754 16011 14772 14695 14704 18768 14281 14773 18430 228785 14701 19735 14702 50779 16476 104111 14708 18749 12915 54409 11536 12310 11514 432530 216869 11908 18125 56533 18755 20191 64214 54401 16193 26385 12909 381489 12797 22629 12325 24012 17896 50778 18751 14745 56089 108058 18761 18127 109624 14873 12918 18750 22631 19087 14693 66066 18430 16010 20192 67865 104418 19737 11938 16008 58175 14682 14697 22627 18429 19084 19739 55948 11513 107503 234779 16176 14707 11535 19734 16440 18760 11465 14709 140498 14696 19085 56470 11461 53419 14391 18753 20683 14390 11512 14915 16438 12323 12921 19773 238871 23872 11910 104110 18799 19736 51791 20541 14916 109689 14609 22628 12297 12778 16006 18769 18578 14699 18767 22630 12913 11464 16009 18803 14683 17133 12315 11909 14706 11515 11459 14688 17906 50780 16439 18797 12322 18033 12912 60596 Dysregulated miRNA targeting in insulin PI3K AKT signaling%WikiPathways_20260910%WP3855%Mus musculus Dysregulated miRNA targeting in insulin PI3K AKT signaling 12825 14252 12843 12444 56717 53867 20662 12703 14104 107476 12125 26987 19108 12929 12827 26417 18710 53413 12043 12015 18708 12842 19744 12576 19087 110157 Wnt signaling in kidney disease%WikiPathways_20260910%WP3857%Mus musculus Wnt signaling in kidney disease 216799 11848 12387 16348 16973 228357 22408 22409 22410 22421 93735 22420 22418 22414 22411 22417 22416 22419 22412 22413 22415 22422 14362 14370 14366 57265 14369 14371 14367 14368 14365 13543 13544 13542 26420 26414 26419 56637 12005 17311 93687 11789 12234 Triacylglyceride synthesis%WikiPathways_20260910%WP386%Mus musculus Triacylglyceride synthesis 15450 14555 67512 14732 66853 67800 228061 16890 16956 233549 52123 68393 68262 50784 14712 67717 13350 14933 67916 14626 19012 55979 28169 Robo4 and VEGF signaling pathways crosstalk%WikiPathways_20260910%WP3864%Mus musculus Robo4 and VEGF signaling pathways crosstalk 74144 20563 16542 19353 22339 20779 IL 6 signaling pathway%WikiPathways_20260910%WP387%Mus musculus IL 6 signaling pathway 269643 56458 16194 18708 26395 19229 14159 235542 20848 12371 14388 26931 107951 18709 17977 17164 56637 12702 26399 12367 20416 20850 19053 12608 16193 20662 13867 16195 229317 14281 13866 26416 19052 12015 73699 19303 20846 16476 12229 14360 26413 14784 26409 433759 12569 19247 11651 16451 20393 21405 16331 11835 18033 13163 110157 26419 72508 54721 17762 15461 14083 26407 71978 21939 20112 14191 26417 18803 19645 72930 22324 21682 20851 16332 15507 13685 14389 26396 21770 19353 15519 328572 16452 54601 226849 51792 26398 12169 13684 225849 18099 12914 18753 110854 15162 56484 12568 17096 26932 ACE inhibitor pathway%WikiPathways_20260910%WP396%Mus musculus ACE inhibitor pathway 11421 16644 11609 11607 19702 19701 18127 11606 12062 mir 193a and MVP in colon cancer metastasis%WikiPathways_20260910%WP3979%Mus musculus mir 193a and MVP in colon cancer metastasis 27041 53872 78388 17869 12443 12444 miR 127 in mesendoderm differentiation%WikiPathways_20260910%WP3991%Mus musculus miR 127 in mesendoderm differentiation 320202 387146 11477 12627 17126 18119 11480 17128 15376 20997 21331 Mitochondrial long chain fatty acid beta oxidation%WikiPathways_20260910%WP401%Mus musculus Mitochondrial long chain fatty acid beta oxidation 50790 20280 12896 74147 14081 13177 11409 97212 12894 74205 11363 11364 11370 15107 57279 111175 Wnt signaling%WikiPathways_20260910%WP403%Mus musculus Wnt signaling 13544 11848 19353 18792 18751 18755 14296 56637 11789 22416 14365 26420 27373 12443 16835 14370 18760 22421 22411 22408 18750 16476 93897 14369 26931 22419 12387 22413 18754 22414 20379 18752 18472 13543 22420 12445 22418 14362 93735 14368 22417 26932 22415 12005 22410 18761 14367 22422 13542 18759 22409 14283 26414 17869 18762 12444 14371 30050 18753 57265 Kit receptor signaling pathway%WikiPathways_20260910%WP407%Mus musculus Kit receptor signaling pathway 14786 18708 18709 20416 12983 14784 54607 67296 56468 12700 67300 12928 20779 74055 16452 71520 19273 56792 18750 18803 20846 20850 20851 30955 23921 14783 11651 21682 17096 13448 15170 19247 13857 20111 17342 26413 11350 16331 14191 15162 22612 218397 14159 12929 12402 12703 22324 22325 17179 12015 20662 328572 14360 18751 15461 110157 114716 114715 58194 208650 21933 12229 16590 17311 26395 20848 17475 GPCRs other%WikiPathways_20260910%WP41%Mus musculus GPCRs other 319757 12614 18343 81014 14608 18329 259009 15550 12311 56696 18356 171469 80978 170732 113858 18315 113863 69296 11542 13617 107934 113845 18323 18387 22312 57260 213527 18321 18354 81011 18350 11554 14371 218066 78249 18344 81016 18322 113859 18390 257890 113853 66786 113846 18324 18361 18359 13489 233670 80910 259044 14367 53883 14816 18363 113849 258923 113864 58182 11539 76206 113862 27216 14788 259007 18316 258702 18352 18372 21338 18349 12801 258703 18241 17202 11555 81015 80290 64378 20609 64379 18332 26364 18317 113851 13488 12777 58861 18310 113854 18330 15552 14369 258435 18362 14766 23890 113855 13349 81013 22311 20132 18341 18389 18373 18357 13609 259115 14739 57265 13492 113856 110326 24112 54393 81012 113860 258153 18328 12374 22296 258859 208188 404316 113857 81010 18347 18331 18345 81017 22313 18351 258706 22354 113850 18358 113848 14362 113852 113847 258343 29848 170648 258326 258826 113865 244701 94226 22297 23832 71111 18346 12775 18307 Oxidative stress response%WikiPathways_20260910%WP412%Mus musculus Oxidative stress response 394436 26462 14281 13057 17161 20683 26416 26414 13076 14872 18032 12359 14782 20657 14778 14629 17748 18104 50493 20656 15368 16477 14391 14775 18033 56615 20655 56551 G1 to S cell cycle control%WikiPathways_20260910%WP413%Mus musculus G1 to S cell cycle control 12567 12571 12443 12444 12445 12575 12576 12572 66671 13555 242705 13557 19650 19645 104394 13559 50496 21781 211586 12566 12447 12448 18974 18973 12530 22390 268930 12534 12544 19891 68240 68275 17216 17215 17217 17218 17219 17220 18392 18393 50793 26428 26429 56452 19075 19076 18969 18538 22059 13197 17246 12580 12579 12581 12578 12427 11920 12577 12452 17869 17420 Distal convoluted tubule 1 DCT1 cell%WikiPathways_20260910%WP4183%Mus musculus Distal convoluted tubule 1 DCT1 cell 16517 69847 12283 53416 232341 56365 20497 Ethanol metabolism resulting in production of ROS by CYP2E1%WikiPathways_20260910%WP4265%Mus musculus Ethanol metabolism resulting in production of ROS by CYP2E1 26419 13106 20683 26396 17133 17134 26395 17135 18024 18753 Nuclear receptors in lipid metabolism and toxicity%WikiPathways_20260910%WP431%Mus musculus Nuclear receptors in lipid metabolism and toxicity 11303 19013 12780 19016 18171 27413 19401 13124 13077 27409 11307 13082 12355 22337 76408 13088 13122 218772 13115 19411 13120 18670 13081 22259 18671 20186 13106 26874 19015 69050 19299 Eicosanoid lipid synthesis map%WikiPathways_20260910%WP4335%Mus musculus Eicosanoid lipid synthesis map 18784 53357 18783 211429 74451 19225 64292 19215 11689 TCA cycle%WikiPathways_20260910%WP434%Mus musculus TCA cycle 18563 18597 68263 27273 170718 27402 235339 13382 66945 17449 20917 11429 381511 56451 78920 18604 15929 66052 228026 66925 67680 12974 20916 67834 236900 269951 18293 18598 382051 14194 17448 Sphingolipid metabolism overview%WikiPathways_20260910%WP4344%Mus musculus Sphingolipid metabolism overview 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 67260 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 Glycerolipids and glycerophospholipids%WikiPathways_20260910%WP4345%Mus musculus Glycerolipids and glycerophospholipids 14732 19012 66586 212862 68671 74596 320951 13350 27388 66853 18805 104418 19210 18618 68262 52858 12651 13026 75320 102247 67800 18778 116939 Cholesterol metabolism with Bloch and Kandutsch Russell pathways%WikiPathways_20260910%WP4346%Mus musculus Cholesterol metabolism with Bloch and Kandutsch Russell pathways 20787 110446 11303 12642 15357 13122 22259 20652 14104 13360 235293 13595 73166 13116 104086 223920 110460 208715 15360 17855 68603 192156 20775 319554 320581 14137 14593 110196 16987 74754 22260 11307 218203 20788 14081 74205 50790 26897 171210 18194 74754 54326 12686 83603 68801 76267 56473 20249 20250 13121 73166 66234 98386 15490 18194 Eicosanoid metabolism via cyclooxygenases COX %WikiPathways_20260910%WP4347%Mus musculus Eicosanoid metabolism via cyclooxygenases COX 19223 21391 15446 18784 19015 69050 53357 18783 211429 19224 19225 64292 19215 11677 67103 77219 13117 277753 13118 64385 72054 11430 93732 80911 113868 74147 19222 66469 19220 19214 14764 21390 19224 Eicosanoid metabolism via lipoxygenases LOX %WikiPathways_20260910%WP4348%Mus musculus Eicosanoid metabolism via lipoxygenases LOX 13117 16993 211666 625249 72054 14775 11689 66447 11687 15446 13850 17001 277753 13118 64385 72054 11430 93732 80911 74147 113868 14598 23887 13479 319446 11684 67103 77219 Eicosanoid metabolism via cytochrome P450 monooxygenases%WikiPathways_20260910%WP4349%Mus musculus Eicosanoid metabolism via cytochrome P450 monooxygenases 13850 13117 277753 13118 64385 72054 13095 13096 13097 13098 13099 226143 404195 72082 13109 19013 One carbon metabolism%WikiPathways_20260910%WP435%Mus musculus One carbon metabolism 108156 69606 13433 14450 13436 13361 11720 12116 108645 108147 14317 21452 17768 434437 108037 238505 53320 77683 269378 20425 270685 13435 17769 210009 110147 107747 74340 22171 107885 Omega 3 omega 6 fatty acid synthesis%WikiPathways_20260910%WP4350%Mus musculus Omega 3 omega 6 fatty acid synthesis 56473 14081 74205 50790 54326 68801 76267 11430 80911 26897 171210 74205 50790 18784 53357 18783 211429 Omega 9 fatty acid synthesis%WikiPathways_20260910%WP4351%Mus musculus Omega 9 fatty acid synthesis 76267 14081 14104 74205 50790 54326 68801 170439 12686 54325 20250 56473 26897 171210 PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine%WikiPathways_20260910%WP4398%Mus musculus PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine 18595 16765 Matrix metalloproteinases%WikiPathways_20260910%WP441%Mus musculus Matrix metalloproteinases 26561 234911 17390 17385 17388 240047 17395 17392 118453 21858 17393 17384 23948 58223 12215 17381 17389 21411 17387 214766 30800 21857 17394 17386 21859 17391 21926 83995 110595 Oxidative stress and redox pathway%WikiPathways_20260910%WP4466%Mus musculus Oxidative stress and redox pathway 14780 18477 22166 50868 332309 12505 14854 75475 20511 26570 20371 14873 14870 14775 20514 433899 625249 14776 14381 14664 14629 18024 11689 18181 14871 14857 14782 12411 15926 56615 14863 14660 14630 110175 14778 75512 67305 69590 269951 14380 110208 14872 103140 14862 14864 14865 14866 14867 68312 14858 14859 14860 14869 68214 211666 66447 54486 76263 23887 71522 207182 14598 12780 27416 66988 16790 104245 28248 24059 12477 13058 13057 19353 17972 17969 17970 21672 11757 53381 54683 11758 320769 19224 19225 20201 20202 20655 20656 20657 50493 26462 232223 Adipogenesis genes%WikiPathways_20260910%WP447%Mus musculus Adipogenesis genes 20378 27217 22410 20185 13591 13865 14362 16334 16370 22408 116939 20787 16369 15251 20183 20181 12606 18196 20683 12153 12608 12387 17873 21405 230709 13819 228775 17977 268903 20602 11606 16846 14705 20528 16905 12156 19883 13555 12159 14463 14560 16878 13198 16890 12912 19223 16880 13197 13542 14102 52637 93691 11622 17319 57264 67512 20851 12804 18534 13046 20847 66277 14234 19651 18787 12224 17260 19645 20848 17984 110075 14461 17127 11537 232174 20852 16193 20745 14599 21803 11450 15903 22419 13654 59027 14462 56758 11604 11520 22160 20846 19650 19016 97064 22259 12609 104394 14815 21926 23849 19013 20379 16956 64898 17978 14245 13386 18413 16195 19017 16333 12702 20249 13082 17258 384783 103968 19401 105980076 17259 19015 69050 11770 12703 22227 16000 56458 20850 64899 15361 17261 19116 74551 16367 21887 Circulating monocytes and cardiac macrophages in diastolic dysfunction%WikiPathways_20260910%WP4474%Mus musculus Circulating monocytes and cardiac macrophages in diastolic dysfunction 20296 16153 20750 12772 Complement and coagulation cascades%WikiPathways_20260910%WP449%Mus musculus Complement and coagulation cascades 19123 12259 16644 14058 17174 12258 21788 22371 18792 232345 12946 12269 14069 58992 12509 21824 18815 50908 12266 12628 109828 11905 13136 12267 14962 14061 18787 14066 13137 109821 14068 14067 69379 18793 18816 18791 12263 56373 17194 15139 12274 17175 50909 12260 14071 14062 12268 12630 12273 12061 11537 15160 19128 17221 12902 12262 268591 14060 16621 110135 12279 Elongation of very long chain fatty acids%WikiPathways_20260910%WP4491%Mus musculus Elongation of very long chain fatty acids 14104 68801 12686 54325 74559 170439 83603 54326 56473 170439 68801 76267 12686 30049 20249 20250 329065 56473 54325 74559 76267 IL 2 signaling pathway%WikiPathways_20260910%WP450%Mus musculus IL 2 signaling pathway 16183 20851 16453 12928 22324 20846 12912 23872 17096 11651 21752 12700 23871 19247 14694 12703 20850 230126 18707 13684 12402 20844 16818 16185 16184 110157 12508 15894 56717 27979 16451 14784 26395 20963 12043 17346 18708 12702 15962 74769 16432 26419 14389 20848 12675 19229 16452 22608 18709 14815 18795 19697 18706 16186 56324 18033 18762 26396 64685 14360 16653 26420 17164 26413 72508 30955 12929 20662 26416 15519 26417 16367 56484 15170 20416 384783 Osteoclast signaling%WikiPathways_20260910%WP454%Mus musculus Osteoclast signaling 18383 18591 194352 21943 11433 15977 20544 66290 21934 15975 16416 13038 238377 20750 GPCRs class B secretin like%WikiPathways_20260910%WP456%Mus musculus GPCRs class B secretin like 12311 54598 12921 12922 381853 93896 14652 14527 14602 213527 19228 11517 319229 22354 22355 26364 13733 330814 99633 319387 170757 237175 Inflammatory response pathway%WikiPathways_20260910%WP458%Mus musculus Inflammatory response pathway 12524 21938 16779 15978 21827 22370 16183 16190 16185 16818 16777 16186 16189 12825 21939 12842 16782 12843 12487 21947 21937 14268 12519 16184 226519 22637 16776 21825 16191 16192 Blood clotting cascade%WikiPathways_20260910%WP460%Mus musculus Blood clotting cascade 14058 14061 58992 99571 18815 14071 14070 18792 110135 22371 14067 14060 109821 18816 18791 18788 18787 14069 14068 14161 Lipids measured in liver metastasis from breast cancer%WikiPathways_20260910%WP4627%Mus musculus Lipids measured in liver metastasis from breast cancer 79235 Sphingolipid metabolism integrated pathway %WikiPathways_20260910%WP4690%Mus musculus Sphingolipid metabolism integrated pathway 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 71949 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 76893 67260 Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle%WikiPathways_20260910%WP4763%Mus musculus Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle 19017 56637 21425 19017 21425 T cell receptor signaling pathway%WikiPathways_20260910%WP480%Mus musculus T cell receptor signaling pathway 72699 218397 12481 22325 26411 12501 22376 16453 12503 78473 108723 20662 94176 56233 14389 12387 12929 19395 14360 27387 20851 18003 16428 13800 14281 20218 18709 22323 72349 71520 12525 20663 18019 12507 23853 54353 12928 17096 11431 13430 26431 18761 19303 15170 14784 16797 16818 20963 26417 545902 12700 18708 11308 16476 101540 13383 77647 18479 53416 19271 12488 12504 19247 20850 12500 242687 11857 17975 23939 23880 26396 22165 24055 192656 54126 104248 73341 20779 16438 14083 22248 22145 17829 11350 26558 12608 14357 18803 20416 26413 19248 20846 230126 57257 329693 16923 16822 26395 109905 208650 77799 240754 17973 26401 22324 12402 12914 22154 545622 109880 19200 20491 74039 19264 22637 13169 19229 12502 14026 215280 19260 19354 27371 12912 54390 12540 19056 94212 11651 17444 12042 107746 GDNF RET signaling axis%WikiPathways_20260910%WP4820%Mus musculus GDNF RET signaling axis 24063 17300 20671 14048 20666 18504 58198 11609 14234 14573 14462 329628 268902 12159 16869 20563 23892 19713 14585 14634 67042 72938 12387 Peroxiredoxin 2 induced ovarian failure%WikiPathways_20260910%WP4835%Mus musculus Peroxiredoxin 2 induced ovarian failure 12028 13063 13070 15494 12367 20845 21672 Alpha 6 beta 4 integrin signaling pathway%WikiPathways_20260910%WP488%Mus musculus Alpha 6 beta 4 integrin signaling pathway 11848 20166 192897 14360 23844 14083 16403 16785 22352 229933 14784 13518 59079 13866 18708 18709 18710 18706 74769 30955 18707 12821 20416 19882 55948 16772 16777 226519 16776 16779 16773 16774 16780 16782 18479 19353 18810 12476 384783 16367 13649 11835 22062 11350 54401 22627 22629 22631 22612 109620 17295 13685 13684 16418 18208 11651 12367 12015 18750 56717 18753 17393 20779 17126 17127 12575 Mapk signaling pathway%WikiPathways_20260910%WP493%Mus musculus Mapk signaling pathway 21813 19252 17165 13712 170706 26940 19418 12929 216869 110651 26403 16765 218397 12369 320139 381921 22059 16177 12368 13649 11652 21926 13198 12928 69253 15370 14175 12475 11911 14103 65964 13197 21812 19055 12367 68652 18752 26409 56274 12370 109689 19419 14784 269275 16151 109880 26420 20807 26415 53859 26565 26401 19279 18596 26396 21809 19259 16653 19042 16175 12531 14281 18755 78405 12371 17451 16150 15507 11479 11651 53608 19059 50932 12540 110157 50772 23939 26408 18753 18176 18751 26414 11909 26404 13645 18099 16476 26407 225028 26413 71751 21808 193740 18784 216965 26395 63953 18049 19043 17164 14828 67603 30957 319520 224105 26398 225724 240672 19060 109905 19058 26921 17869 66513 15481 21803 13163 18033 26417 233046 17762 26399 18762 103988 18015 23797 19056 19354 12362 12064 18479 26419 16178 18747 26416 22030 26400 19057 215449 29857 22034 18211 26410 17532 16176 20663 235584 114713 14673 12366 19353 17260 26411 18591 23938 14102 192176 17187 16478 Deregulation of renin angiotensin system by SARS CoV infection%WikiPathways_20260910%WP4965%Mus musculus Deregulation of renin angiotensin system by SARS CoV infection 11607 70008 11421 11609 Hypoxia dependent self renewal of myoblasts%WikiPathways_20260910%WP5023%Mus musculus Hypoxia dependent self renewal of myoblasts 15213 15205 15214 17877 17879 17927 12575 18509 17928 18128 56458 15251 22027 Hypoxia dependent proliferation of myoblasts%WikiPathways_20260910%WP5024%Mus musculus Hypoxia dependent proliferation of myoblasts 22339 17700 433766 17927 22084 15234 67731 17877 64930 11651 17127 16000 74747 19744 14164 56717 17126 17928 12310 Hypoxia dependent differentiation of myoblasts%WikiPathways_20260910%WP5025%Mus musculus Hypoxia dependent differentiation of myoblasts 12575 26416 17877 17878 18128 112405 12576 319594 15251 17879 17928 20893 22339 17928 Na K ATPase Src signaling%WikiPathways_20260910%WP5051%Mus musculus Na K ATPase Src signaling 230661 19354 56637 11928 11798 22165 14360 20662 109905 12391 16542 12015 170758 20363 14784 12043 110157 17295 13649 26420 320207 18479 20811 16202 18481 11796 107746 50772 11797 12387 243659 330662 20418 11836 12928 26396 26397 30955 12371 15461 56717 13067 109880 26413 12444 13063 14083 22324 23797 241656 51789 18595 12445 11931 23938 215449 12143 14254 26419 19353 20459 20779 224105 83813 26399 214230 225724 12929 12390 12389 20416 70584 11783 23939 11651 74769 18707 13866 18596 109880 26395 12443 16001 18706 15162 19211 13712 75669 12367 12927 11652 18708 18709 16476 29857 14191 Burn wound healing%WikiPathways_20260910%WP5056%Mus musculus Burn wound healing 22339 18127 16772 12842 21926 15200 21803 18613 73122 18126 14248 11459 14609 56189 216799 Nuclear Receptors%WikiPathways_20260910%WP509%Mus musculus Nuclear Receptors 20182 26379 218772 14815 26424 22026 19411 18227 11835 18667 21907 11819 22337 26423 21834 353187 21833 19885 20183 19883 19015 69050 13865 19016 26563 11614 15370 20181 13983 22260 22259 19401 13982 18171 13864 19013 15378 26380 12355 ID signaling pathway%WikiPathways_20260910%WP512%Mus musculus ID signaling pathway 15901 15902 15903 15904 19645 19651 19650 21423 17927 12566 12428 12447 13712 13714 13713 19185 15205 18507 18504 18510 17877 17878 17928 21406 20787 17681 12156 12168 22339 14254 16542 17125 17128 17129 11910 17127 21815 11482 16818 16001 16000 16367 12387 21752 18033 19697 12161 21947 18049 13645 21416 Fibrin complement receptor 3 signaling pathway%WikiPathways_20260910%WP5128%Mus musculus Fibrin complement receptor 3 signaling pathway 11651 16193 16150 18706 18815 18033 20963 19696 142980 208650 17874 15977 11848 16179 18791 15945 54354 117149 22034 106759 12475 22177 14127 330122 18815 266632 17087 16803 21898 20779 225471 54131 16409 16414 21926 20296 12675 16151 14161 108960 16160 18126 110135 99571 19697 Oxylipins pathways%WikiPathways_20260910%WP5140%Mus musculus Oxylipins pathways 15446 13850 66469 19215 64292 19223 21391 11689 11688 11684 11687 76267 56473 19225 17001 16993 14598 13479 14775 12408 54486 13850 Proteasome degradation%WikiPathways_20260910%WP519%Mus musculus Proteasome degradation 19171 22190 319170 93841 19166 15007 19186 19170 26442 15007 66997 67151 19184 22210 16913 17463 19172 66105 69077 22201 103963 19182 51788 26445 16912 15978 19167 22223 15007 53380 15007 22123 23997 56550 20014 15270 66413 26444 26440 74153 19175 26443 19173 19192 19179 66998 216080 17999 67089 23996 19185 22187 15007 26441 19188 19177 19181 15007 26446 21762 57296 19184 Biogenic amine synthesis%WikiPathways_20260910%WP522%Mus musculus Biogenic amine synthesis 14417 13195 21990 15186 13166 21823 18948 11423 12846 18478 12647 11298 14415 17161 107626 Regulation of actin cytoskeleton%WikiPathways_20260910%WP523%Mus musculus Regulation of actin cytoskeleton 56419 108083 26413 12671 18719 227753 231637 18479 18643 225326 14176 18590 14163 320207 20663 108100 29875 22330 14165 16801 54126 14674 19684 77579 329165 243764 12669 240752 14180 13649 13800 237860 232906 170758 242687 241656 227733 17532 26395 16885 12061 14178 22349 14673 50884 14169 11461 18709 224105 14186 14174 213788 14167 12540 19241 18705 13645 226970 12927 107589 245857 14175 18708 18481 330662 12672 12632 12475 18596 67771 18706 14083 80857 14171 11848 20544 14184 18704 64654 74769 12062 19878 14170 14172 18718 56636 18176 14173 18710 22350 19877 11465 67112 14268 80903 30955 73341 17901 19353 109880 17931 22376 66922 75669 20130 11789 66985 18595 16653 14168 18720 83767 70584 109711 14701 13367 18717 20662 17698 12928 16334 109700 110157 12988 117150 26417 18591 76884 17897 26396 19303 19354 16333 14183 18707 50772 214230 23805 216963 12631 17451 14177 14164 14061 14062 14182 14166 14179 22324 225724 101314 Lac Phe pathway%WikiPathways_20260910%WP5240%Mus musculus Lac Phe pathway 27416 66054 Comprehensive IL 17A signaling%WikiPathways_20260910%WP5242%Mus musculus Comprehensive IL 17A signaling 20302 20311 14268 20304 12540 11459 14825 20315 20303 11475 16000 24099 14118 15511 20613 17345 17220 11522 15289 12842 18591 15132 20656 269437 20311 22059 18749 11749 18792 16176 19225 17392 20846 14219 19353 56717 107589 14701 320011 16193 17218 12367 18590 19325 66870 266692 12266 76709 67089 18793 19697 18938 104184 20583 20309 11848 18481 16176 109828 17387 56378 14432 66922 67771 11927 12282 269823 11600 17395 20310 100503605 15129 13649 19704 230709 18393 19646 12540 19353 18793 56045 12301 22589 18392 18792 18148 50927 18538 19290 98415 18412 67443 12043 17130 17126 56208 20848 66734 17131 225326 17217 17219 17216 21803 17215 56717 20315 17126 17127 11651 20613 20583 21872 16452 Dravet syndrome Scn1a A1783V point mutation model%WikiPathways_20260910%WP5298%Mus musculus Dravet syndrome Scn1a A1783V point mutation model 20265 20501 19049 13823 20511 12298 12297 16832 20512 14580 16828 55936 17161 12295 16542 12286 19417 14810 12287 109731 12294 21926 20912 14802 14660 72821 18706 279653 56716 54393 14415 18033 14400 14396 242425 14811 53623 14402 235281 55943 14645 20910 20266 56717 399548 109270 20269 14799 78757 16490 12322 20265 72446 244059 227743 19094 14168 11651 14417 108069 228960 14394 57138 16524 16519 16513 20525 20503 76257 20527 232333 14395 14397 72961 Globo series sphingolipid metabolism%WikiPathways_20260910%WP5305%Mus musculus Globo series sphingolipid metabolism 14344 227671 93961 26879 Wnt signaling pathway%WikiPathways_20260910%WP539%Mus musculus Wnt signaling pathway 22218 22413 99470 14200 21374 93840 11789 57265 13728 77578 22415 12387 93687 13543 13542 14368 26419 23859 12005 14371 23988 12322 109689 26413 22418 14362 58198 22408 212398 13385 11651 16842 93960 27373 26417 19099 208846 104318 17127 13017 26420 11848 18099 26564 20319 20664 19353 20377 12443 14367 216869 12534 13132 22417 140577 56637 13380 17863 12995 26992 16973 14366 319478 20682 12532 12393 12234 18504 21413 16971 12550 26409 56505 108058 59004 16974 26965 75826 13000 14369 22416 16480 17128 22421 14370 15258 12323 12961 18751 13383 26423 16476 21418 67087 18750 13001 328572 13016 14296 21402 110157 12325 12006 76281 21423 13544 17755 19052 Synthesis and degradation of ketone bodies%WikiPathways_20260910%WP543%Mus musculus Synthesis and degradation of ketone bodies 15356 110446 15360 67041 71911 Exercise induced circadian regulation%WikiPathways_20260910%WP544%Mus musculus Exercise induced circadian regulation 22229 30960 11865 20610 18627 12608 22763 18701 14864 75062 319187 12952 22057 54375 19290 52331 64209 19053 12741 353187 14373 13690 12953 12753 17878 50884 15502 217166 12417 27057 53412 14011 216558 18626 238988 22153 23994 14869 19317 15481 68652 26441 14585 14998 16601 12226 19663 22218 319554 Steroid biosynthesis%WikiPathways_20260910%WP55%Mus musculus Steroid biosynthesis 15497 13074 15493 15496 15492 15495 15494 15486 15487 15485 14060 15488 15490 Calcium regulation in cardiac cells%WikiPathways_20260910%WP553%Mus musculus Calcium regulation in cardiac cells 12295 12325 20191 50779 104110 14702 432530 12322 18751 12290 64337 50778 67972 14678 53313 320707 14613 18797 11549 14696 18821 58175 18749 20190 12326 224129 18768 216869 67865 11550 11554 51791 12292 12672 243764 12288 14615 16500 210044 14609 16439 19085 12289 108058 14695 12286 16519 19737 54401 14697 16521 22631 22629 14611 16438 11941 14620 14621 55948 18760 14701 14682 66066 18753 14708 14623 14679 18754 64214 24012 14773 14709 18767 20192 16440 11514 12669 56470 11548 12315 14225 14618 14616 56533 12372 104111 22627 11749 14672 14707 11515 19734 20541 22630 11513 14687 11556 14622 12317 50782 14699 18762 19084 14693 18769 19736 18755 19088 18761 14704 18750 118454 14688 12373 14681 110893 18821 11938 19735 109689 14683 14619 12287 14677 12671 19739 213788 12323 14612 14706 22628 52163 12297 18752 11512 14772 19087 11555 50780 14617 26385 27222 11931 11936 11932 11933 Eukaryotic transcription initiation%WikiPathways_20260910%WP567%Mus musculus Eukaryotic transcription initiation 235459 24074 13872 68705 229906 23894 67710 102216272 108143 20022 68153 74197 245841 67065 20019 209357 99730 26939 20016 21343 66464 16202 20018 17749 20020 69920 14884 78929 66671 12572 20017 226182 67005 66420 21374 70428 231329 14885 17420 20021 13871 Signal transduction of S1P receptor%WikiPathways_20260910%WP57%Mus musculus Signal transduction of S1P receptor 26417 18705 13610 26413 26934 13609 20698 14677 23939 18797 11652 54447 20598 14678 94226 29857 23797 11651 50772 56632 14679 14739 Monoamine GPCRs%WikiPathways_20260910%WP570%Mus musculus Monoamine GPCRs 15465 11553 15562 13490 15466 12671 11549 13492 15564 13491 11556 11548 243764 15565 15552 12669 15566 12672 13489 213788 11551 15558 15557 13488 15563 11554 11552 15560 15559 15550 11550 15551 11555 FAS pathway and stress induction of HSP regulation%WikiPathways_20260910%WP571%Mus musculus FAS pathway and stress induction of HSP regulation 20740 16175 14084 12369 15507 192656 13368 18479 11783 13163 17164 12370 11545 13347 11857 14103 14082 19645 26419 16476 102626 26398 12368 224105 26409 16906 16907 12371 12633 12043 26401 12367 21926 19090 16905 19249 14102 EGFR1 signaling pathway%WikiPathways_20260910%WP572%Mus musculus EGFR1 signaling pathway 13645 110157 15461 18176 16653 56392 18708 26405 50915 14784 14783 26406 20662 14786 18709 20416 18710 18706 74769 18707 30955 14388 14389 16451 20846 16452 20848 20850 20847 20851 26395 18750 26401 18762 18760 18759 18751 26396 26397 23938 26407 22324 57257 22325 23939 26413 26417 13714 13712 26419 26400 19279 14609 54401 232341 13649 110310 16691 16667 16668 382523 107686 18810 19248 20779 12402 12928 12929 67184 19353 19229 12389 12390 17973 17974 18803 216963 19734 12703 12702 16332 271457 98910 11843 22687 19766 53859 19730 218397 20459 19084 15170 19247 22038 74155 13449 18738 80794 208650 18806 18805 13858 13860 15194 240752 56726 12988 194590 19765 64143 19707 51789 11308 20663 13429 20408 12540 24064 16478 14281 12606 17869 12608 23980 194655 20466 21815 433759 58194 20404 16476 20683 11651 19259 20617 20111 110651 20112 11771 73178 26365 13627 72993 216190 23942 13859 13854 215114 19727 26416 57783 245688 13196 20910 12388 109333 18479 27387 12927 12371 73086 17126 17127 11908 12912 56458 19303 13710 107435 12322 16396 11836 109904 234779 19252 Leptin insulin signaling overlap%WikiPathways_20260910%WP578%Mus musculus Leptin insulin signaling overlap 16452 18607 16847 12702 20848 18710 11651 216233 30955 16337 12703 16333 104418 16846 16367 384783 16369 16370 Integrin mediated cell adhesion%WikiPathways_20260910%WP6%Mus musculus Integrin mediated cell adhesion 16401 73647 109711 16202 14083 16416 16407 20662 22793 109905 16409 12928 16404 16421 12337 381924 20363 19877 16410 16400 22330 107746 16399 12338 19354 19303 214230 26395 12927 192897 320910 18607 12335 20779 330662 57257 109880 12390 16408 11836 268958 23830 16411 109700 14360 26414 12988 12391 212541 15461 23939 12389 16420 50772 20416 16412 12334 23797 26396 18709 104099 21961 12339 16402 213119 110157 22325 12540 23938 12336 16414 224105 26397 26413 20411 215449 26399 18481 16398 11652 12333 19353 19878 26431 22323 16403 18479 11651 14784 16419 241226 319480 54126 228785 70584 225724 29857 170758 21894 20418 miR 1 in cardiac development%WikiPathways_20260910%WP608%Mus musculus miR 1 in cardiac development 16508 54352 15111 Pentose phosphate pathway%WikiPathways_20260910%WP63%Mus musculus Pentose phosphate pathway 14381 66171 66646 21351 19895 21881 110208 Insulin signaling%WikiPathways_20260910%WP65%Mus musculus Insulin signaling 18710 210789 16369 16568 14252 20111 20913 20910 26414 19354 19246 110651 26408 11652 72508 26406 56458 20911 12402 13712 15461 13684 12702 13660 26419 19268 26412 104215 14281 22433 26396 19211 50932 20418 20912 16370 11845 26405 23921 26420 22084 110157 26397 18709 14251 73086 18642 18753 18704 16890 13685 53859 19159 20662 18751 225724 50915 26415 23938 16573 16476 14936 17913 107746 19353 19094 18707 50772 56637 14784 14388 18755 26417 170755 108079 18708 80794 58988 232493 75669 20909 27219 26921 56717 20614 399510 16332 23939 18761 208650 12703 14783 26407 11840 26409 26399 233071 22318 16367 26413 20416 12928 269180 26401 19341 16150 269881 225326 30955 259300 64930 20112 216148 18607 18706 11651 26400 80837 12331 29857 53608 18705 26395 67071 18759 19247 56437 71751 18762 74769 225028 338372 19744 19047 434233 26404 20807 56484 20619 20663 56613 18750 26398 18641 27357 20411 105787 26410 20393 228775 26403 26416 26411 13653 18605 16001 16337 20525 20528 Amino acid metabolism%WikiPathways_20260910%WP662%Mus musculus Amino acid metabolism 14782 15186 12411 20603 17449 14860 18746 11898 11754 107508 13382 18534 14661 15360 140483 13195 11364 14719 11992 27273 19125 78920 14085 74147 15109 105148 11668 320092 227095 234724 69719 212679 12116 12035 113868 58875 108682 18452 18597 22018 14630 11532 18242 242083 26876 17161 21823 231691 102436 14378 22375 16828 11522 14660 66945 23874 27053 18597 110695 246221 56451 15356 11529 18563 209027 18293 109900 14854 14194 107869 21990 17850 11846 17448 15926 18948 13166 11429 14645 104458 72039 18263 14317 56454 14718 12974 104112 22321 27402 56720 18416 66925 68738 227231 20810 15107 11847 Leptin and adiponectin%WikiPathways_20260910%WP683%Mus musculus Leptin and adiponectin 72674 105787 19079 16846 68465 107476 19082 16847 12894 11450 Wnt signaling pathway and pluripotency%WikiPathways_20260910%WP723%Mus musculus Wnt signaling pathway and pluripotency 22059 71978 18761 13543 73699 14362 22418 16974 269643 18751 22411 14369 13017 19053 19052 12914 13542 14366 21415 93735 14283 52432 14370 21413 26409 56637 14296 13016 22410 71887 17869 16835 22419 12387 22408 22411 22422 22416 12444 13544 17393 26420 22421 18044 18750 22414 16842 26931 72293 21410 14365 20674 18792 18755 18760 22413 30050 18472 19015 69050 18099 51792 21405 18752 18762 14368 57265 72930 12006 12445 14367 22417 71950 11789 26932 16476 328572 22412 16973 12388 22420 26414 18753 110854 18999 12443 12005 26934 22409 27373 22415 56805 93960 18754 14371 18759 15221 11848 12505 Glutathione and one carbon metabolism%WikiPathways_20260910%WP730%Mus musculus Glutathione and one carbon metabolism 16790 14381 23887 14775 12116 13433 210009 17769 14630 14782 14598 14854 14629 434437 74340 238505 108645 13435 218865 14598 14776 13436 11720 75475 15926 269378 20425 14778 108037 625249 12411 107869 Tryptophan metabolism%WikiPathways_20260910%WP79%Mus musculus Tryptophan metabolism 64385 70790 15930 13106 57751 270076 56752 15469 11669 19378 107626 13076 17246 18293 109731 11671 13195 15108 12359 22215 15107 13123 23923 110446 70789 71562 13078 11298 11761 74754 266645 13077 72082 22375 21743 13075 11668 320092 13110 107766 76507 93747 56720 13107 21990 Focal adhesion%WikiPathways_20260910%WP85%Mus musculus Focal adhesion 12826 230661 11465 18607 19354 56637 107589 53867 21828 22165 14360 20662 12831 16420 105083 109905 12391 12015 319480 170758 12815 16780 20363 14784 329278 12043 110157 227377 12333 15234 17295 13649 11848 16404 16409 12843 26420 320207 15891 18479 12832 20811 16202 94216 228785 18481 21827 16398 11796 16773 107746 18717 12824 12829 50772 13645 192897 16402 11797 16775 320910 381924 16416 19878 16776 243659 330662 12643 20418 213119 11836 12928 26396 26397 81877 170736 30955 16400 12842 16403 14205 109880 192176 26413 12444 71785 13367 17931 16410 14083 22330 16772 22371 12825 22324 23797 16411 241656 51789 16414 18595 12445 54635 23938 16399 215449 12143 14254 26419 19353 23928 19877 20459 21826 12540 16421 22793 20779 224105 18591 83813 20750 26399 214230 225724 12929 14268 11855 12814 16401 12390 12389 22370 16000 20416 109711 18654 70584 11852 18590 23939 11651 19303 74769 18707 13866 18596 109880 26395 226519 12443 16779 22340 21894 18706 16774 15162 19211 22341 16777 13712 19699 75669 12827 11461 16412 241226 16407 104099 22339 12834 16419 21825 16408 12927 11652 18708 18709 16782 22323 21923 17904 16476 29857 14191 21960 Toll like receptor signaling%WikiPathways_20260910%WP88%Mus musculus Toll like receptor signaling 24088 21898 117149 142980 17153 73914 266632 225471 17874 16179 19765 106759 108960 14082 22031 12367 12370 56489 11308 54131 56480 22026 26416 12675 68652 19106 22034 26399 16150 17121 16151 18033 18034 IL 4 signaling pathway%WikiPathways_20260910%WP93%Mus musculus IL 4 signaling pathway 18762 11651 18033 56468 16190 20852 18708 19094 72508 15170 16451 13712 26413 13449 19247 16453 17969 16818 20662 20850 15361 384783 20416 14083 14159 14360 16189 54721 16367 18707 218397 26417 26416 16164 20844 18753 12767 12914 20846 18759 12702 12015 16452 114774 20375 320129 328572 23871 75292 20779 18803 16331 11909 14784 12703 16186 18706 18709 19697 12402 12048}